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Sample records for implemented enhanced sinusoid

  1. CFD study on NACA 4415 airfoil implementing spherical and sinusoidal Tubercle Leading Edge.

    Science.gov (United States)

    Aftab, S M A; Ahmad, K A

    2017-01-01

    The Humpback whale tubercles have been studied for more than a decade. Tubercle Leading Edge (TLE) effectively reduces the separation bubble size and helps in delaying stall. They are very effective in case of low Reynolds number flows. The current Computational Fluid Dynamics (CFD) study is on NACA 4415 airfoil, at a Reynolds number 120,000. Two TLE shapes are tested on NACA 4415 airfoil. The tubercle designs implemented on the airfoil are sinusoidal and spherical. A parametric study is also carried out considering three amplitudes (0.025c, 0.05c and 0.075c), the wavelength (0.25c) is fixed. Structured mesh is utilized to generate grid and Transition SST turbulence model is used to capture the flow physics. Results clearly show spherical tubercles outperform sinusoidal tubercles. Furthermore experimental study considering spherical TLE is carried out at Reynolds number 200,000. The experimental results show that spherical TLE improve performance compared to clean airfoil.

  2. CFD study on NACA 4415 airfoil implementing spherical and sinusoidal Tubercle Leading Edge.

    Directory of Open Access Journals (Sweden)

    S M A Aftab

    Full Text Available The Humpback whale tubercles have been studied for more than a decade. Tubercle Leading Edge (TLE effectively reduces the separation bubble size and helps in delaying stall. They are very effective in case of low Reynolds number flows. The current Computational Fluid Dynamics (CFD study is on NACA 4415 airfoil, at a Reynolds number 120,000. Two TLE shapes are tested on NACA 4415 airfoil. The tubercle designs implemented on the airfoil are sinusoidal and spherical. A parametric study is also carried out considering three amplitudes (0.025c, 0.05c and 0.075c, the wavelength (0.25c is fixed. Structured mesh is utilized to generate grid and Transition SST turbulence model is used to capture the flow physics. Results clearly show spherical tubercles outperform sinusoidal tubercles. Furthermore experimental study considering spherical TLE is carried out at Reynolds number 200,000. The experimental results show that spherical TLE improve performance compared to clean airfoil.

  3. Automatic fringe enhancement with novel bidimensional sinusoids-assisted empirical mode decomposition.

    Science.gov (United States)

    Wang, Chenxing; Kemao, Qian; Da, Feipeng

    2017-10-02

    Fringe-based optical measurement techniques require reliable fringe analysis methods, where empirical mode decomposition (EMD) is an outstanding one due to its ability of analyzing complex signals and the merit of being data-driven. However, two challenging issues hinder the application of EMD in practical measurement. One is the tricky mode mixing problem (MMP), making the decomposed intrinsic mode functions (IMFs) have equivocal physical meaning; the other is the automatic and accurate extraction of the sinusoidal fringe from the IMFs when unpredictable and unavoidable background and noise exist in real measurements. Accordingly, in this paper, a novel bidimensional sinusoids-assisted EMD (BSEMD) is proposed to decompose a fringe pattern into mono-component bidimensional IMFs (BIMFs), with the MMP solved; properties of the resulted BIMFs are then analyzed to recognize and enhance the useful fringe component. The decomposition and the fringe recognition are integrated and the latter provides a feedback to the former, helping to automatically stop the decomposition to make the algorithm simpler and more reliable. A series of experiments show that the proposed method is accurate, efficient and robust to various fringe patterns even with poor quality, rendering it a potential tool for practical use.

  4. Diagnostic performance of Contrast-enhanced CT in Pyrrolizidine Alkaloids-induced Hepatic Sinusoidal Obstructive Syndrome

    Science.gov (United States)

    Kan, Xuefeng; Ye, Jin; Rong, Xinxin; Lu, Zhiwen; Li, Xin; Wang, Yong; Yang, Ling; Xu, Keshu; Song, Yuhu; Hou, Xiaohua

    2016-01-01

    Hepatic sinusoidal obstruction syndrome (HSOS) can be caused by pyrrolizidine alkaloids(PAs)-containing herbals. Since PAs exposure is obscure and clinical presentation of HSOS is unspecific, it is challenge to establish the diagnosis of PAs-induced HSOS. Gynura segetum is one of the most wide-use herbals containing PAs. The aim of our study is to describe the features of contrast-enhanced computed tomography (CT) in gynura segetum-induced HSOS, and then determine diagnostic performance of radiological signs. We retrospectively analyzed medical records and CT images of HSOS patients (71 cases) and the controls (222 cases) enrolled from January 1, 2008, to Oct 31, 2015. The common findings of contrast CT in PAs-induced HSOS included: ascites (100%), hepatomegaly (78.87%), gallbladder wall thickening (86.96%), pleural effusion (70.42%), hepatic vein narrowing (87.32%), patchy liver enhancement (92.96%), and heterogeneous hypoattenuation (100%); of these signs, patchy enhancement and heterogeneous hypoattenuation were valuable features. Then, the result of diagnostic performance demonstrated that contrast CT possessed better performance in diagnosing PAs-induced HSOS compared with various parameters of Seattle criteria. In conclusion, the patients with PAs-induced HSOS display distinct radiologic features at CT-scan, which reveals that contrast-enhanced CT provides an effective noninvasive method for diagnosing PAs-induced HSOS. PMID:27897243

  5. On the Fully-Developed Heat Transfer Enhancing Flow Field in Sinusoidally, Spirally Corrugated Tubes Using Computational Fluid Dynamics

    DEFF Research Database (Denmark)

    Hærvig, Jakob; Sørensen, Kim; Condra, Thomas Joseph

    2017-01-01

    A numerical study has been carried out to investigate heat transfer enhancing flow field in 28 geometrically different sinusoidally, spirally corrugated tubes. To vary the corrugation, the height of corrugation e/D and the length between two successive corrugated sections p/D are varied in the ra...

  6. Efficiency enhancement of a self-propelled pitching profile using non-sinusoidal trajectories

    Science.gov (United States)

    Mekadem, M.; Chihani, E.; Oualli, H.; Hanchi, S.; Bouabdallah, A.; Gad-El-Hak, M.

    2017-11-01

    A symmetrical profile is subjected to non-sinusoidal pitching motion. The airfoil has a chord length c = 0.006 m and a semi-circular leading edge with a diameter of D = 0.001 m. The extrados and intrados are two straight lines that intersect at a tapered trailing edge, and the pitching pivot point is positioned at the leading edge. The pitching frequency is in the range of 1 based upon the maximum profile thickness D varies in the range of 35 <= Re <= 210 , which matches insect's Reynolds numbers. The foil movement is executed using the dynamic mesh technique and a user defined function (UDF). The adopted mesh has 70,445 nodes with 5,1960 quadrilateral cells. The results are in good agreement with prior experiments, and, compared to sinusoidal oscillations, show that non-sinusoidal flapping trajectories lead to advancing velocity increase of 550%. Additionally, if improved propulsive efficiency is sought, non-sinusoidal flapping lead to better thrust.

  7. Highly enhanced avalanche probability using sinusoidally-gated silicon avalanche photodiode

    Energy Technology Data Exchange (ETDEWEB)

    Suzuki, Shingo; Namekata, Naoto, E-mail: nnao@phys.cst.nihon-u.ac.jp; Inoue, Shuichiro [Institute of Quantum Science, Nihon University, 1-8-14 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-8308 (Japan); Tsujino, Kenji [Tokyo Women' s Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666 (Japan)

    2014-01-27

    We report on visible light single photon detection using a sinusoidally-gated silicon avalanche photodiode. Detection efficiency of 70.6% was achieved at a wavelength of 520 nm when an electrically cooled silicon avalanche photodiode with a quantum efficiency of 72.4% was used, which implies that a photo-excited single charge carrier in a silicon avalanche photodiode can trigger a detectable avalanche (charge) signal with a probability of 97.6%.

  8. Contrast-enhanced ultrasonography of hepatocellular carcinoma: Correlation between quantitative parameters and arteries in neoangiogenesis or sinusoidal capillarization

    International Nuclear Information System (INIS)

    Pei Xiaoqing; Liu Longzhong; Zheng Wei; Cai Muyan; Han Feng; He Jiehua; Li Anhua; Chen Minshan

    2012-01-01

    Objective: The quantitative parameters in contrast-enhanced ultrasonography-time–intensity curve of hepatocellular carcinoma (HCC) were studied to explore their potential importance in monitoring the effects of anti-angiogenic therapy for HCC. Methods: 115 HCC patients were studied with contrast-enhanced ultrasonography-time–intensity curve (CEUS-TIC) and with immunohistochemical analysis of tissue sections. The CEUS images were analyzed off-line to obtained quantitative parameters including maximum of intensity (IMAX), rise time (RT), time to peak (TTP), mean transit time (mTT), rise slope (RS), and washout time (WT). Monoclonal antibodies specific for smooth muscle actin and anti-CD34 were used to observe unpaired arteries (UAs) and microvessel area (MVA) of sinusoidal capillarization, respectively. The UAs and MVA of 82 HCC cases were successfully stained. Results: The number of UAs had moderate correlation with RT (r = −0.446), TTP (r = −0.432), and RS (r = 0.431) (P < 0.05), and it had mild correlation with IMAX (r = 0.303) and WT (r = 0.285) (P < 0.05). MVA of sinusoidal capillarization had no correlation with perfusion parameters. Conclusion: Quantitative CEUS-TIC parameters reflecting hemodynamics of tumors are correlated with UAs, but not with MVA, and they might be used to monitor the effects of anti-angiogenic therapy on HCC.

  9. TRAIL enhances paracetamol-induced liver sinusoidal endothelial cell death in a Bim- and Bid-dependent manner

    Science.gov (United States)

    Badmann, A; Langsch, S; Keogh, A; Brunner, T; Kaufmann, T; Corazza, N

    2012-01-01

    Paracetamol (acetaminophen, APAP) is a universally used analgesic and antipyretic agent. Considered safe at therapeutic doses, overdoses cause acute liver damage characterized by centrilobular hepatic necrosis. One of the major clinical problems of paracetamol-induced liver disease is the development of hemorrhagic alterations. Although hepatocytes represent the main target of the cytotoxic effect of paracetamol overdose, perturbations within the endothelium involving morphological changes of liver sinusoidal endothelial cells (LSECs) have also been described in paracetamol-induced liver disease. Recently, we have shown that paracetamol-induced liver damage is synergistically enhanced by the TRAIL signaling pathway. As LSECs are constantly exposed to activated immune cells expressing death ligands, including TRAIL, we investigated the effect of TRAIL on paracetamol-induced LSEC death. We here demonstrate for the first time that TRAIL strongly enhances paracetamol-mediated LSEC death with typical features of apoptosis. Inhibition of caspases using specific inhibitors resulted in a strong reduction of cell death. TRAIL appears to enhance paracetamol-induced LSEC death via the activation of the pro-apoptotic BH3-only proteins Bid and Bim, which initiate the mitochondrial apoptotic pathway. Taken together this study shows that the liver endothelial layer, mainly LSECs, represent a direct target of the cytotoxic effect of paracetamol and that activation of TRAIL receptor synergistically enhances paracetamol-induced LSEC death via the mitochondrial apoptotic pathway. TRAIL-mediated acceleration of paracetamol-induced cell death may thus contribute to the pathogenesis of paracetamol-induced liver damage. PMID:23254290

  10. Enhancing implementation security of QKD

    Science.gov (United States)

    Tamaki, Kiyoshi

    2017-10-01

    Quantum key distribution (QKD) can achieve information-theoretic security, which is a provable security against any eavesdropping, given that all the devices the sender and the receiver employ operate exactly as the theory of security requires. Unfortunately, however, it is difficult for practical devices to meet all such requirements, and therefore more works have to be done toward guaranteeing information-theoretic security in practice, i.e., implementation security. In this paper, we review our recent efforts to enhance implementation security. We also have a brief look at a flaw in security proofs and present how to fix it.

  11. Mathematical Models of the Sinusoidal Screen Family

    Directory of Open Access Journals (Sweden)

    Tajana Koren

    2011-06-01

    Full Text Available In this paper we will define a family of sinusoidal screening elements and explore the possibilities of their application in graphic arts, securities printing and design solutions in photography and typography editing. For this purpose mathematical expressions of sinusoidal families were converted into a Postscript language. The introduction of a random variable results in a countless number of various mutations which cannot be repeated without knowing the programming code itself. The use of the family of screens in protection of securities is thus of great importance. Other possible application of modulated sinusoidal screens is related to the large format color printing. This paper will test the application of sinusoidal screens in vector graphics, pixel graphics and typography. The development of parameters in the sinusoidal screen element algorithms gives new forms defined within screening cells with strict requirements of coverage implementation. Individual solutions include stochastic algorithms, as well as the autonomy of screening forms in regard to multicolor printing channels.

  12. Sinusoidal obstructive syndrome diagnosed with superparamagnetic iron oxide-enhanced magnetic resonance imaging in patients with chemotherapy-treated colorectal liver metastases.

    Science.gov (United States)

    Ward, Janice; Guthrie, James A; Sheridan, Maria B; Boyes, Sheila; Smith, Jonathan T; Wilson, Daniel; Wyatt, Judy I; Treanor, Darren; Robinson, Philip J

    2008-09-10

    To assess the predictive value of superparamagnetic iron oxide (SPIO) -enhanced T2-weighted gradient echo (GRE) imaging to determine the presence and severity of sinusoidal obstructive syndrome (SOS). Sixty hepatic resection patients with colorectal metastases treated with chemotherapy underwent unenhanced magnetic resonance imaging (MRI) followed by T2-weighted GRE sequences obtained after SPIO. The images were reviewed in consensus by two experienced observers who determined the presence and severity of linear and reticular hyperintensities, indicating SOS-type liver injury, using a 4-point ordinal scale. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) with 95% CIs for the detection of SOS were calculated. Twenty-four of 60 patients had moderate to severe SOS on MRI. MRI achieved a sensitivity of 87% (95% CI, 66% to 97%), specificity of 89% (95% CI, 75% to 97%), PPV of 83% (95% CI, 63% to 95%), and NPV of 92% (95% CI, 77% to 98%). SOS was never found at surgery or histology in patients whose background liver parenchyma was normal on SPIO-enhanced MRI. SOS is present in a significant proportion of patients with treated colorectal metastases and is effectively detected on SPIO-enhanced T2-weighted GRE images.

  13. Sinusoidal obstruction syndrome.

    Science.gov (United States)

    Valla, Dominique-Charles; Cazals-Hatem, Dominique

    2016-09-01

    Sinusoidal obstruction syndrome (SOS) is characterized by damage to small hepatic vessels affecting particularly sinusoidal endothelium. Damaged sinusoids can be associated with a partial or complete occlusion of small hepatic veins, hence the previous denomination of hepatic veno-occlusive disease (VOD). Exposure to certain exogenous toxins appears to be specific to this condition and is frequently included in its definition. Typical histopathological features of SOS in a liver biopsy specimen are presented in the text. The purpose of this article is to provide an overview on the different entities corresponding to this general definition. Such entities include: (i) liver disease related to pyrrolizidine alcaloids; (ii) liver injury related to conditioning for hematopoietic stem cell transplantation; (iii) vascular liver disease occurring in patients treated with chemotherapy for liver metastasis of colorectal cancer; and (iv) other liver diseases related to toxic agents. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  14. Noise upon the Sinusoids

    DEFF Research Database (Denmark)

    Jensen, Karl Kristoffer

    2005-01-01

    Sinusoids are used for making harmonic and other sounds. In order to having life in the sounds and adding a wide variety of noises, irregularities are inserted in the frequency and amplitudes. A simple and intuitive noise model is presented, consisting of a low-pass filtered noise, and having...... control for strength and bandwidth. The noise is added on the frequency and amplitudes of the sinusoids, and the resulting irregularity’s (jitter and shimmer) bandwidth is derived. This, together with an overview of investigation methods of the jitter and shimmer results in an analysis of the necessary...

  15. Sinusoidal Representation of Acoustic Signals

    Science.gov (United States)

    Honda, Masaaki

    Sinusoidal representation of acoustic signals has been an important tool in speech and music processing like signal analysis, synthesis and time scale or pitch modifications. It can be applicable to arbitrary signals, which is an important advantage over other signal representations like physical modeling of acoustic signals. In sinusoidal representation, acoustic signals are composed as sums of sinusoid (sine wave) with different amplitudes, frequencies and phases, which is based on the timedependent short-time Fourier transform (STFT). This article describes the principles of acoustic signal analysis/synthesis based on a sinusoid representation with focus on sine waves with rapidly varying frequency.

  16. Sinusoids theory and technological applications

    CERN Document Server

    Kythe, Prem K

    2014-01-01

    A Complete Treatment of Current Research Topics in Fourier Transforms and Sinusoids Sinusoids: Theory and Technological Applications explains how sinusoids and Fourier transforms are used in a variety of application areas, including signal processing, GPS, optics, x-ray crystallography, radioastronomy, poetry and music as sound waves, and the medical sciences. With more than 200 illustrations, the book discusses electromagnetic force and sychrotron radiation comprising all kinds of waves, including gamma rays, x-rays, UV rays, visible light rays, infrared, microwaves, and radio waves. It also covers topics of common interest, such as quasars, pulsars, the Big Bang theory, Olbers' paradox, black holes, Mars mission, and SETI.The book begins by describing sinusoids-which are periodic sine or cosine functions-using well-known examples from wave theory, including traveling and standing waves, continuous musical rhythms, and the human liver. It next discusses the Fourier series and transform in both continuous and...

  17. Clinical implementation of enhanced dynamic wedge

    International Nuclear Information System (INIS)

    Klein, Eric E.; Zhu Xiaorong; Low, Daniel A.; Drzymala, Robert E.; Harms, William B.; Purdy, James A.

    1996-01-01

    Purpose/Objective: Our clinic has been using dynamic wedge since 1993. We appreciate the customized wedge shaped distributions (independent of field size) and the positive aspects of replacing filters with dynamic jaw motion. Varian recently introduced enhanced dynamic wedge (EDW) software. The EDW can be delivered over; a 30 cm field, asymmetric fields (in both wedged and non-wedged directions), and additional wedge angles (10, 15, 20, 25, 30, 45, 60). The EDW software creates customized segmented treatment tables (STTs) for the desired wedge angle and field size. The STT is created from a 'golden' fluence profile of 60 deg. over 30 cm. The wedge STT is derived using ratio-of-tangents and the truncated field segment extracted from the 'golden' table. A review of our dosimetric studies will be presented as well as a discussion of clinical implementation issues including treatment planning and quality assurance. Methods and Materials: We tested a set of angle and field size combinations chosen to encompass clinical needs. The wedge factor (WF) was measured using an ionization chamber along central axis for symmetric fields ranging from 4 to 20 cm, and asymmetric fields to 30 cm. The non-wedged field dimension was found to be inconsequential. An algorithm was developed to predict the wedge factor for any angle and field dimension. Isodoses were measured with film and used for profile evaluation and treatment planning development. The 'golden' fluence table was used to create a universal 60 deg. 'physical' wedge for planning. The universal wedge is combined with an open field (to derive intermediate wedge angles) and blocked according to the treatment field segment. A quality assurance program was developed that relies on multi-point diode measurements. Results: We found the WF is a function of wedge angle and field settings of the final sweep position. There is a nearly linear dependence of WF vs. field size thus allowing a minimal WF table. This eliminates a

  18. Napa River Sediment TMDL Implementation and Habitat Enhancement Project

    Science.gov (United States)

    Information about the SFBWQP Napa River Sediment TMDL Implementation and Habitat Enhancement Project, part of an EPA competitive grant program to improve SF Bay water quality focused on restoring impaired waters and enhancing aquatic resources.

  19. Cosmology and the Sinusoidal Potential

    Science.gov (United States)

    Bartlett, David F.

    2006-06-01

    The nature of dark matter (and dark energy) remains a mystery. An alternative is being explored by several scientists: changing Newton's (and Einstein's) field equations. The sinusoidal potential is the latest attempt[1]. Here the gravitational law is alternately attractive and repulsive:φ = -GM cos(kor)/r, where λo=2π/ko = 1/20 of the distance from the sun to the center of the Milky Way. The proposal accommodates several structural features of the Milky Way including, paradoxically, its spiral shape and flat rotation curve. The sinusoidal potential's unique feature is strong galactic tidal forces (dg/dr). These may explain why the new planetoid Sedna is securely between the Kuiper Belt and the Oort cloud and why distant comets are more influenced by galactic tides that are in the r, rather than the z-direction.At this meeting I discuss the consequences of the sinusoidal potential for cosmology. Here the alternation of attraction and repulsion gives (i) an open universe, and (ii) gravitational lensing which is usually weak, but occasionally very strong. An open universe is one that, asymptotically, has a size R which varies directly as time t. The open universe conflicts both with the old Einstein-deSitter model (R α t2/3} and the new accelerating one. The evidence for an accelerating universe decisively rejects the Einstein-deSitter model. The rejection of an open (or empty) universe is less secure. This rejection is influenced by the different ways the groups studying the brightness of supernovae use the HST. Surprising additional inputs include neutrino masses, the equivalence principle, LSB galaxies, and "over-luminous" Sn1a. I thank Mostafa Jon Dadras and Patrick Motl for early help and John Cumalat for continual support. [1] D.F. Bartlett, "Analogies between electricity and gravity", Metrologia 41, S115-S124 (2004).

  20. Sinusoidal Order Estimation Using Angles between Subspaces

    Directory of Open Access Journals (Sweden)

    Søren Holdt Jensen

    2009-01-01

    Full Text Available We consider the problem of determining the order of a parametric model from a noisy signal based on the geometry of the space. More specifically, we do this using the nontrivial angles between the candidate signal subspace model and the noise subspace. The proposed principle is closely related to the subspace orthogonality property known from the MUSIC algorithm, and we study its properties and compare it to other related measures. For the problem of estimating the number of complex sinusoids in white noise, a computationally efficient implementation exists, and this problem is therefore considered in detail. In computer simulations, we compare the proposed method to various well-known methods for order estimation. These show that the proposed method outperforms the other previously published subspace methods and that it is more robust to the noise being colored than the previously published methods.

  1. Single ICCII Sinusoidal Oscillators Employing Grounded Capacitors

    Directory of Open Access Journals (Sweden)

    J. W. Horng

    2011-09-01

    Full Text Available Two inverting second-generation current conveyors (ICCII based sinusoidal oscillators are presented. The first sinusoidal oscillator is composed of one ICCII, two grounded capacitors and two resistors. The oscillation condition and oscillation frequency can be orthogonally controllable. The second sinusoidal oscillator is composed of one ICCII, two grounded capacitors and three resistors. The oscillation condition and oscillation frequency can be independently controllable through different resistors.

  2. Electronically tunable RC sinusoidal oscillators

    International Nuclear Information System (INIS)

    Florescu, Valeriu

    2008-01-01

    This paper presents two types of active configurations for realizing electronically tunable RC sinusoidal oscillators. The type-1 network employs two grounded scaled resistances KR 1 and KR 2 , where K is scaling factor. The frequency of oscillation W 0 is controlled conveniently by adjusting K, since W 0 appears in the form W 0 =1/K √ R 1 C 1 R 2 C 2 . For realizing the scaled resistances, an active configuration is proposed, which realizes KR 1 =R 1 /(1+f(V B )), where f(V B ) denotes a function of a controlling voltage V B . Thus the frequency tuning can be effected by controlling a voltage V B . The type-2 oscillator uses two periodically switched conductances. It is shown that the tuning of oscillation frequency can be done by varying the pulse width-to-period ratio (t/T) of the periodically switched conductances. (author)

  3. Galalctic Tides & the Sinusoidal Potential

    Science.gov (United States)

    Bartlett, David F.

    2011-05-01

    The sinusoidal potential is a nonNewtonian alternative to dark matter. Instead of φ = -GM/r we write φ = -(GM/r) cos kor, where ko= 2π/ λo and λo = Ro/20= 400 pc. Evidence for this choice for the "wavelength” λo has been given in one article and many previous meetings of the AAS & DDA. The solar system and nearby stars are trapped in a local groove of width Δr Quality (4 types) and semi-major axis aoriginal . For 10 of the 12 classes radial tides dominate Z-tides. The classic Oort cloud comets (1851-1996) have a particularly strong modulation with galactic longitude. This modulation is exactly in those directions where a radial tide would be important. The equally numerous recent Oort comets (1996-2008) show a different evidence for strong radial tides. The recent comets generally have much larger perihelion distances q than the classic ones. Here the evidence is that a radial tide is removing angular momentum from the orbit and thus bringing the perihelion closer to the earth and to observers.

  4. Sinusoidal masks for single channel speech separation

    DEFF Research Database (Denmark)

    Mowlaee, Pejman; Christensen, Mads Græsbøll; Jensen, Søren Holdt

    2010-01-01

    In this paper we present a new approach for binary and soft masks used in single-channel speech separation. We present a novel approach called the sinusoidal mask (binary mask and Wiener filter) in a sinusoidal space. Theoretical analysis is presented for the proposed method, and we show...... that the proposed method is able to minimize the target speech distortion while suppressing the crosstalk to a predetermined threshold. It is observed that compared to the STFTbased masks, the proposed sinusoidal masks improve the separation performance in terms of objective measures (SSNR and PESQ) and are mostly...

  5. Implementing enhanced recovery pathways: a literature review with realist synthesis.

    Science.gov (United States)

    Coxon, Astrid; Nielsen, Karina; Cross, Jane; Fox, Chris

    2017-10-01

    Enhanced Recovery Pathways (ERPs) are an increasingly popular, evidenced-based approach to surgery, designed to improve patient outcomes and reduce costs. Despite evidence demonstrating the benefits of these pathways, implementation and adherence have been inconsistent. Using realist synthesis, this review explored the current literature surrounding the implementation of ERPs in the UK. Knowledge consolidation between authors and consulting with field experts helped to guide the search strategy. Relevant medical and social science databases were searched from 2000 to 2016, as well as a general web search. A total of 17 papers were identified, including original research, reviews, case studies and guideline documents. Full texts were analysed, cross-examined, and data extracted and synthesised. Several implementation strategies were identified, including the contexts in which these operated, the subsequent mechanisms of action that were triggered, and the outcome patterns they produced. Context-Mechanism-Outcome (CMO) configurations were generated, tested, and refined. These were grouped to develop two programme theories concerning ERP implementation, one related to the strategy of consulting with staff, the other with appointing a change agent to coordinate and drive the implementation process. These theories highlight instances in which implementation could be improved. Current literature in ERP research is primarily focussed on measuring patient outcomes and cost effectiveness, and as a result, important detail regarding the implementation process is often not reported or described robustly. This review not only provides recommendations for future improvements in ERP implementation, but also highlights specific areas of focus for furthering ERP implementation research.

  6. Fibronectin Extra Domain A Promotes Liver Sinusoid Repair following Hepatectomy.

    Directory of Open Access Journals (Sweden)

    Bridget Sackey-Aboagye

    Full Text Available Liver sinusoidal endothelial cells (LSECs are the main endothelial cells in the liver and are important for maintaining liver homeostasis as well as responding to injury. LSECs express cellular fibronectin containing the alternatively spliced extra domain A (EIIIA-cFN and increase expression of this isoform after liver injury, although its function is not well understood. Here, we examined the role of EIIIA-cFN in liver regeneration following partial hepatectomy. We carried out two-thirds partial hepatectomies in mice lacking EIIIA-cFN and in their wild type littermates, studied liver endothelial cell adhesion on decellularized, EIIIA-cFN-containing matrices and investigated the role of cellular fibronectins in liver endothelial cell tubulogenesis. We found that liver weight recovery following hepatectomy was significantly delayed and that sinusoidal repair was impaired in EIIIA-cFN null mice, especially females, as was the lipid accumulation typical of the post-hepatectomy liver. In vitro, we found that liver endothelial cells were more adhesive to cell-deposited matrices containing the EIIIA domain and that cellular fibronectin enhanced tubulogenesis and vascular cord formation. The integrin α9β1, which specifically binds EIIIA-cFN, promoted tubulogenesis and adhesion of liver endothelial cells to EIIIA-cFN. Our findings identify a role for EIIIA-cFN in liver regeneration and tubulogenesis. We suggest that sinusoidal repair is enhanced by increased LSEC adhesion, which is mediated by EIIIA-cFN.

  7. HR practices for enhancing sustainable employability : implementation, use, and outcomes

    OpenAIRE

    Ybema, Jan Fekke; van Vuuren, Tinka; van Dam, Karen

    2017-01-01

    With the aging of the workforce, organizations need to maintain or improve the sustainable employability of their workforce throughout their working life. This raises the question which HR practices increase workers’ sustainable employability at work. The aim of this study is to investigate the extent to which organizations implement HR practices for enhancing sustainable employability in terms of workers’ health, motivation, and skills and knowledge from the employer’s perspective. In total,...

  8. Encryption in Chaotic Systems with Sinusoidal Excitations

    Directory of Open Access Journals (Sweden)

    G. Obregón-Pulido

    2014-01-01

    Full Text Available In this contribution an encryption method using a chaotic oscillator, excited by “n” sinusoidal signals, is presented. The chaotic oscillator is excited by a sum of “n” sinusoidal signals and a message. The objective is to encrypt such a message using the chaotic behavior and transmit it, and, as the chaotic system is perturbed by the sinusoidal signal, the transmission security could be increased due to the effect of such a perturbation. The procedure is based on the regulation theory and consider that the receiver knows the frequencies of the perturbing signal, with this considerations the algorithm estimates the excitation in such a way that the receiver can cancel out the perturbation and all the undesirable dynamics in order to produce only the message. In this way we consider that the security level is increased.

  9. Safety culture enhancement through the implementation of IAEA guidelines

    International Nuclear Information System (INIS)

    Mengolini, A.; Debarberis, L.

    2007-01-01

    This paper presents the methodology applied and the results achieved in adapting and implementing the IAEA guidelines on safety culture to a research reactor as a step towards supporting its Life Management Program. The background is presented together with the effort undertaken to develop awareness on safety culture and the enhancement programme hereafter developed. The present study shows how issues of safety culture, management awareness and commitment deserve attention and can be of fundamental relevance also for research reactors. The study presents how guidelines developed specifically for nuclear power installations (NPPs) can be adapted to meet the needs and peculiarities of other nuclear installations. Moreover, the difficulties met during the implementation of the guidelines are discussed and important information and lessons can be learnt for the nuclear industry in general

  10. Recommendations for Enhancing Implementation of Additional Protocol Declarations

    International Nuclear Information System (INIS)

    Niina, Toshiaki; Nidaira, Kazuo; Aono, Yosuke

    2010-01-01

    Japan signed the Additional Protocol (hereafter, AP) in December 1998. The domestic law and regulation had been revised to implement the initial and annual declarations for the Agency and the Additional Protocol came into force in December 1999. Since initial declaration in 2000, Japan has submitted the annual declaration in every May. Until 2010, Japan has made 10 annual declarations. This paper gives recommendations to enhance implementation of Additional Protocol declarations based on 10-year experience in Japan and addresses the following: Current status of additional protocol declaration in Japan; Outline of processing method; AP Information Management System; Recommendations for improving quality of declaration. Preparation of additional protocol declaration in NMCC has been conducted in the course of contract with Japan Safeguards Office (hereafter, JSGO) for safeguards information treatment. (author)

  11. Estimating Aquifer Properties Using Sinusoidal Pumping Tests

    Science.gov (United States)

    Rasmussen, T. C.; Haborak, K. G.; Young, M. H.

    2001-12-01

    We develop the theoretical and applied framework for using sinusoidal pumping tests to estimate aquifer properties for confined, leaky, and partially penetrating conditions. The framework 1) derives analytical solutions for three boundary conditions suitable for many practical applications, 2) validates the analytical solutions against a finite element model, 3) establishes a protocol for conducting sinusoidal pumping tests, and 4) estimates aquifer hydraulic parameters based on the analytical solutions. The analytical solutions to sinusoidal stimuli in radial coordinates are derived for boundary value problems that are analogous to the Theis (1935) confined aquifer solution, the Hantush and Jacob (1955) leaky aquifer solution, and the Hantush (1964) partially penetrated confined aquifer solution. The analytical solutions compare favorably to a finite-element solution of a simulated flow domain, except in the region immediately adjacent to the pumping well where the implicit assumption of zero borehole radius is violated. The procedure is demonstrated in one unconfined and two confined aquifer units near the General Separations Area at the Savannah River Site, a federal nuclear facility located in South Carolina. Aquifer hydraulic parameters estimated using this framework provide independent confirmation of parameters obtained from conventional aquifer tests. The sinusoidal approach also resulted in the elimination of investigation-derived wastes.

  12. Unidirectional Motion of Vehicle on Sinusoidal Path

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 17; Issue 4. Unidirectional Motion of Vehicle on Sinusoidal Path: Can it Cause Illusory Forward and Backward Motion? Anuj Bhatnagar. Classroom Volume 17 Issue 4 April 2012 pp 387-392 ...

  13. Riding the Ferris Wheel: A Sinusoidal Model

    Science.gov (United States)

    Mittag, Kathleen Cage; Taylor, Sharon E.

    2011-01-01

    When thinking of models for sinusoidal waves, examples such as tides of the ocean, daily temperatures for one year in your town, light and sound waves, and certain types of motion are used. Many textbooks [1, p. 222] also present a "Ferris wheel description problem" for students to work. This activity takes the Ferris wheel problem out of the…

  14. Model selection and comparison for independents sinusoids

    DEFF Research Database (Denmark)

    Nielsen, Jesper Kjær; Christensen, Mads Græsbøll; Jensen, Søren Holdt

    2014-01-01

    In the signal processing literature, many methods have been proposed for estimating the number of sinusoidal basis functions from a noisy data set. The most popular method is the asymptotic MAP criterion, which is sometimes also referred to as the BIC. In this paper, we extend and improve this me...

  15. Crashworthiness Analysis and Evaluation of Fuselage Section with Sub-floor Composite Sinusoidal Specimens

    Directory of Open Access Journals (Sweden)

    H.L. Mou

    Full Text Available Abstract Crashworthiness is one of the main concerns in civil aviation safety particularly with regard to the increasing ratio of carbon fiber reinforced plastic (CFRP in aircraft primary structures. In order to generate dates for model validations, the mechanical properties of T700/3234 were obtained by material performance tests, and energy-absorbing results were gained by quasi-static crushing tests of composite sinusoidal specimens. The correctness of composite material model and single-layer finite element model of composite sinusoidal specimens were verified based on the simulation results and test results that were in good agreement. A typical civil aircraft fuselage section with composite sinusoidal specimens under cargo floor was suggested. The crashworthiness of finite element model of fuselage section was assessed by simulating the vertical drop test subjected to 7 m/s impact velocity, and the influences of different thickness of sub-floor composite sinusoidal specimens on crashworthiness of fuselage section were also analyzed. The simulation results show that the established finite element model can accurately simulate the crushing process of composite sinusoidal specimens; the failure process of fuselage section is more stable, and the safety of occupants can be effectively improved because of the smaller peak accelerations that was limited to human tolerance, a critical thickness of sub-floor composite sinusoidal specimens can restrict the magnitude of acceleration peaks, which has certain reference values for enhancing crashworthiness capabilities of fuselage section and improving the survivability of passengers.

  16. Particle filters for object tracking: enhanced algorithm and efficient implementations

    International Nuclear Information System (INIS)

    Abd El-Halym, H.A.

    2010-01-01

    Object tracking and recognition is a hot research topic. In spite of the extensive research efforts expended, the development of a robust and efficient object tracking algorithm remains unsolved due to the inherent difficulty of the tracking problem. Particle filters (PFs) were recently introduced as a powerful, post-Kalman filter, estimation tool that provides a general framework for estimation of nonlinear/ non-Gaussian dynamic systems. Particle filters were advanced for building robust object trackers capable of operation under severe conditions (small image size, noisy background, occlusions, fast object maneuvers ..etc.). The heavy computational load of the particle filter remains a major obstacle towards its wide use.In this thesis, an Excitation Particle Filter (EPF) is introduced for object tracking. A new likelihood model is proposed. It depends on multiple functions: position likelihood; gray level intensity likelihood and similarity likelihood. Also, we modified the PF as a robust estimator to overcome the well-known sample impoverishment problem of the PF. This modification is based on re-exciting the particles if their weights fall below a memorized weight value. The proposed enhanced PF is implemented in software and evaluated. Its results are compared with a single likelihood function PF tracker, Particle Swarm Optimization (PSO) tracker, a correlation tracker, as well as, an edge tracker. The experimental results demonstrated the superior performance of the proposed tracker in terms of accuracy, robustness, and occlusion compared with other methods Efficient novel hardware architectures of the Sample Important Re sample Filter (SIRF) and the EPF are implemented. Three novel hardware architectures of the SIRF for object tracking are introduced. The first architecture is a two-step sequential PF machine, where particle generation, weight calculation and normalization are carried out in parallel during the first step followed by a sequential re

  17. Lean process management implementation through enhanced problem solving capabilities

    Directory of Open Access Journals (Sweden)

    Perumal Puvanasvaran

    2010-12-01

    Full Text Available All Original Equipment Manufacturers (OEM organizations in Aerospace, Automotive and Electronics industries had to upgrade their functions. These organizations including suppliers and solutions providers are duty bound to improve their functions through strategic initiatives. One such initiative is Lean Process Management. Lean Process Management has proven to aid organizations in developing manufacturing and administrative management solutions and make the organization a leaner at the same time a ‘fitter’ one, achieving World Class standards in terms of production, quality, marketing, etc, etc. The issue or problem is, although a number of authors, experts, researchers have discussed the lean process management as part organization centric issues, they failed to provide an effective lean process management system. Besides the need to formulate an effective lean process as suggested by some authors, another important reason suggested is the employee’s development aspect regarding how to unlock the infinite potential of their workforce. This employee’s development is basically the problem solving capabilities of the employees while implementing the Lean through clear cutting protocols or processes of Lean Process Management. The employees need to be developed and equipped to contribute optimally to the process. Because of this scenario, the main objective of this study is to develop an employees development system which the author has acronym or trademark it as People Development System (PDS to enhance problem solving capability among its employees while implementing the lean process management there. Although, the PDS can be implemented throughout the organization, if it is implemented in a particular department in an organization, it will be feasible to study and analyze its effectiveness in-depth. So, this study documents and analyzes the implementation of Lean process in the Kitting Department of the aerospace company, ABC Company

  18. Biphase sinusoidal oscillator based on negative resistor.

    Science.gov (United States)

    Bayard, Jean

    2010-06-01

    This paper describes a biphase sinusoidal generator which provides two signals: v(ref)=V(M) sin(omegat) and v(out)=V(M) sin(omegat+DeltaPhi), where DeltaPhi is in the range 0, pi/2 or -pi/2, 0 and is not dependent on the frequency value. It is based on a negative resistor and it requires very few components. SPICE simulations and measurements on an experimental setup confirm the theoretical analysis.

  19. Implementing Physical Protection Education for an Enhanced Nuclear Security Culture

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jeong Ho; Kim, Hyun Chul; Shin, Ick Hyun; Lee, Hyung Kyung; Choe, Kwan Kyoo [KINAC, Daejeon (Korea, Republic of)

    2013-10-15

    In this paper, we are going to outline our efforts and experiences at implementing physical protection education. KINAC (as the only designated educational institute) places great effort in delivering an effective and a high-quality education program for physical protection. We have also provided a way for nuclear operators to share the lessons they have gained through their own experiences. We made physical protection education an important communication channel, not only among nuclear operators but also between operators and a regulatory body. There is growing attention given to education and training on the subject of physical protection in order to enhance the nuclear security culture. The IAEA recommends that all personnel in organizations directly involved with the nuclear industry receive regularly education in physical protection according to the recently revised INFCIRC/225/Rev.5. The Korea Institute of Nuclear Nonproliferation and Control (KINAC) and the Nuclear Safety and Security Commission (NSSC), which are mainly responsible for the national nuclear security regime, have already recognized the importance of education and training in physical protection. The NSSC enacted its decree on physical protection education and training in 2010. KINAC was designated as the first educational institute in 2011 and implemented physical protection education as mandatory from 2012.

  20. Implementing Physical Protection Education for an Enhanced Nuclear Security Culture

    International Nuclear Information System (INIS)

    Lee, Jeong Ho; Kim, Hyun Chul; Shin, Ick Hyun; Lee, Hyung Kyung; Choe, Kwan Kyoo

    2013-01-01

    In this paper, we are going to outline our efforts and experiences at implementing physical protection education. KINAC (as the only designated educational institute) places great effort in delivering an effective and a high-quality education program for physical protection. We have also provided a way for nuclear operators to share the lessons they have gained through their own experiences. We made physical protection education an important communication channel, not only among nuclear operators but also between operators and a regulatory body. There is growing attention given to education and training on the subject of physical protection in order to enhance the nuclear security culture. The IAEA recommends that all personnel in organizations directly involved with the nuclear industry receive regularly education in physical protection according to the recently revised INFCIRC/225/Rev.5. The Korea Institute of Nuclear Nonproliferation and Control (KINAC) and the Nuclear Safety and Security Commission (NSSC), which are mainly responsible for the national nuclear security regime, have already recognized the importance of education and training in physical protection. The NSSC enacted its decree on physical protection education and training in 2010. KINAC was designated as the first educational institute in 2011 and implemented physical protection education as mandatory from 2012

  1. Regorafenib suppresses sinusoidal obstruction syndrome in rats.

    Science.gov (United States)

    Okuno, Masayuki; Hatano, Etsuro; Nakamura, Kojiro; Miyagawa-Hayashino, Aya; Kasai, Yosuke; Nishio, Takahiro; Seo, Satoru; Taura, Kojiro; Uemoto, Shinji

    2015-02-01

    Sinusoidal obstruction syndrome (SOS), a form of drug-induced liver injury related to oxaliplatin treatment, is associated with postoperative morbidity after hepatectomy. This study aimed to examine the impact of regorafenib, the first small-molecule kinase inhibitor to show efficacy against metastatic colorectal cancer, on a rat model of SOS. Rats with monocrotaline (MCT)-induced SOS were divided into two groups according to treatment with either regorafenib (6 mg/kg) or vehicle alone, which were administered at 12 and 36 h, respectively, before MCT administration. Histopathologic examination and serum biochemistry tests were performed 48 h after MCT administration. Sinusoidal endothelial cells were evaluated by immunohistochemistry and electron microscopy. To examine whether regorafenib preserved remnant liver function, a 30% hepatectomy was performed in each group. The rats in the vehicle group displayed typical SOS features, whereas these features were suppressed in the regorafenib group. The total SOS scores were significantly lower in the regorafenib group than in the vehicle group. Immunohistochemistry and electron microscopy showed that regorafenib had a protective effect on sinusoidal endothelial cells. The postoperative survival rate after 7 d was significantly better in the regorafenib group than that in the vehicle group (26.7% versus 6.7%, P Regorafenib reduced the phosphorylation of extracellular signal-regulated kinase, which induced matrix metalloproteinase-9 (MMP-9) activation and decreased the activity of MMP-9, one of the crucial mediators of SOS development. Regorafenib suppressed MCT-induced SOS, concomitant with attenuating extracellular signal-regulated kinase phosphorylation, and MMP-9 activation, suggesting that regorafenib may be a favorable agent for use in combination with oxaliplatin-based chemotherapy. Copyright © 2015 Elsevier Inc. All rights reserved.

  2. An Adaptive Filter for the Removal of Drifting Sinusoidal Noise Without a Reference.

    Science.gov (United States)

    Kelly, John W; Siewiorek, Daniel P; Smailagic, Asim; Wang, Wei

    2016-01-01

    This paper presents a method for filtering sinusoidal noise with a variable bandwidth filter that is capable of tracking a sinusoid's drifting frequency. The method, which is based on the adaptive noise canceling (ANC) technique, will be referred to here as the adaptive sinusoid canceler (ASC). The ASC eliminates sinusoidal contamination by tracking its frequency and achieving a narrower bandwidth than typical notch filters. The detected frequency is used to digitally generate an internal reference instead of relying on an external one as ANC filters typically do. The filter's bandwidth adjusts to achieve faster and more accurate convergence. In this paper, the focus of the discussion and the data is physiological signals, specifically electrocorticographic (ECoG) neural data contaminated with power line noise, but the presented technique could be applicable to other recordings as well. On simulated data, the ASC was able to reliably track the noise's frequency, properly adjust its bandwidth, and outperform comparative methods including standard notch filters and an adaptive line enhancer. These results were reinforced by visual results obtained from real ECoG data. The ASC showed that it could be an effective method for increasing signal to noise ratio in the presence of drifting sinusoidal noise, which is of significant interest for biomedical applications.

  3. Enhancing leadership and relationships by implementing a peer mentoring program.

    Science.gov (United States)

    Gafni Lachter, Liat R; Ruland, Judith P

    2018-03-30

    Peer-mentoring is often described as effective means to promote professional and leadership skills, yet evidence on practical models of such programs for occupational therapy students are sparse. The purpose of this study was to evaluate the outcomes of a peer-mentoring program designed for graduate occupational therapy students. Forty-seven second-year student volunteers were randomly assigned to individually mentor first-year students in a year-long program. Students met biweekly virtually or in person to provide mentorship on everyday student issues, according to mentees' needs. Faculty-led group activities prior and during the peer-mentoring program took place to facilitate the mentorship relationships. Program effectiveness was measured using the Multi-factor Leadership Questionnaire (Avolio & Bass, MLQ: Multifactor Leadership Questionnaire, 2004) and an open-ended feedback survey. Results of multi-variate MANOVA for repeated measures indicating significant enhancement in several leadership skills (F(12,46) = 4.0, P = 0.001, η 2  = 0.579). Qualitative data from feedback surveys indicated that an opportunity to help; forming relationships; and structure as enabler were perceived as important participation outcomes. Students expressed high satisfaction and perceived value from their peer-mentoring experience. As we seek ways to promote our profession and the leadership of its members, it is recommended to consider student peer-mentoring to empower them to practice and advance essential career skills from the initial stages of professional development. Evidence found in this study demonstrates that peer-mentoring programs can promote leadership development and establishment of networks in an occupational therapy emerging professional community, at a low cost. The peer-mentoring blueprint and lessons learned are presented with hopes to inspire others to implement peer-mentoring programs in their settings. © 2018 Occupational Therapy Australia.

  4. New Canonic Active RC Sinusoidal Oscillator Circuits Using Second-Generation Current Conveyors with Application as a Wide-Frequency Digitally Controlled Sinusoid Generator

    Directory of Open Access Journals (Sweden)

    Abhirup Lahiri

    2011-01-01

    Full Text Available This paper reports two new circuit topologies using second-generation current conveyors (CCIIs for realizing variable frequency sinusoidal oscillators with minimum passive components. The proposed topologies in this paper provide new realizations of resistance-controlled and capacitor-controlled variable frequency oscillators (VFOs using only four passive components. The first topology employs three CCIIs, while the second topology employs two CCIIs. The second topology provides an advantageous feature of frequency tuning through two grounded elements. Application of the proposed circuits as a wide-frequency range digitally controlled sinusoid generator is exhibited wherein the digital frequency control has been enabled by replacing both the capacitors by two identical variable binary capacitor banks tunable by means of the same binary code. SPICE simulations of the CMOS implementation of the oscillators using 0.35 μm TSMC CMOS technology parameters and bipolar implementation of the oscillators using process parameters for NR200N-2X (NPN and PR200N-2X (PNP of bipolar arrays ALA400-CBIC-R have validated their workability. One of the oscillators (with CMOS implementation is exemplified as a digitally controlled sinusoid generator with frequency generation from 25 kHz to 6.36 MHz, achieved by switching capacitors and with power consumption of 7 mW in the entire operating frequency range.

  5. Amplitude Modulated Sinusoidal Signal Decomposition for Audio Coding

    DEFF Research Database (Denmark)

    Christensen, M. G.; Jacobson, A.; Andersen, S. V.

    2006-01-01

    In this paper, we present a decomposition for sinusoidal coding of audio, based on an amplitude modulation of sinusoids via a linear combination of arbitrary basis vectors. The proposed method, which incorporates a perceptual distortion measure, is based on a relaxation of a nonlinear least......-squares minimization. Rate-distortion curves and listening tests show that, compared to a constant-amplitude sinusoidal coder, the proposed decomposition offers perceptually significant improvements in critical transient signals....

  6. Compressed Domain Packet Loss Concealment of Sinusoidally Coded Speech

    DEFF Research Database (Denmark)

    Rødbro, Christoffer A.; Christensen, Mads Græsbøll; Andersen, Søren Vang

    2003-01-01

    We consider the problem of packet loss concealment for voice over IP (VoIP). The speech signal is compressed at the transmitter using a sinusoidal coding scheme working at 8 kbit/s. At the receiver, packet loss concealment is carried out working directly on the quantized sinusoidal parameters......, based on time-scaling of the packets surrounding the missing ones. Subjective listening tests show promising results indicating the potential of sinusoidal speech coding for VoIP....

  7. Parametric modeling for damped sinusoids from multiple channels

    DEFF Research Database (Denmark)

    Zhou, Zhenhua; So, Hing Cheung; Christensen, Mads Græsbøll

    2013-01-01

    frequencies and damping factors are then computed with the multi-channel weighted linear prediction method. The estimated sinusoidal poles are then matched to each channel according to the extreme value theory of distribution of random fields. Simulations are performed to show the performance advantages......The problem of parametric modeling for noisy damped sinusoidal signals from multiple channels is addressed. Utilizing the shift invariance property of the signal subspace, the number of distinct sinusoidal poles in the multiple channels is first determined. With the estimated number, the distinct...... of the proposed multi-channel sinusoidal modeling methodology compared with existing methods....

  8. Stochastic analysis/synthesis using sinusoidal atoms

    DEFF Research Database (Denmark)

    Jensen, Kristoffer

    2008-01-01

    This work proposes a method for re-synthesizing music for use in perceptual experiments regarding structural changes and in music creation. Atoms are estimated from music audio, modelled in a stochastic model, and re-synthesized from the model pa- rameters. The atoms are found by splitting...... sinusoids into short segments, and modelled into amplitude and envelope shape, frequency, time and duration. A simple model for creating envelopes with percussive, sustained or crescendo shape is presented. Single variable and joint probability density functions are created from the atom parameters and used...... to re-create sounds with the same distribution of the atoms parameters. A novel method for visualization music, the musigram, permits a better understanding of the re- synthesized sounds....

  9. experimental implementation of single-phase, three-level, sinusoidal

    African Journals Online (AJOL)

    Page 1 ... of many multilevel inverter configurations. This paper presents an experimental report of a simplified topology for single-phase, SPWM, three-level voltage source inverter wit R-L load. To keep the power circuit ... employed in many industrial applications such as variable speed drives, uninterruptible power sup-.

  10. Variable Dimension Trellis-Coded Quantization of Sinusoidal Parameters

    DEFF Research Database (Denmark)

    Larsen, Morten Holm; Christensen, Mads G.; Jensen, Søren Holdt

    2008-01-01

    In this letter, we propose joint quantization of the parameters of a set of sinusoids based on the theory of trellis-coded quantization. A particular advantage of this approach is that it allows for joint quantization of a variable number of sinusoids, which is particularly relevant in variable...

  11. Planning, design and implementation of the enhancing child ...

    African Journals Online (AJOL)

    African Journal of Food, Agriculture, Nutrition and Development ... The Enhancing Child Nutrition through Animal Source Management (ENAM) project ... community development, research and capacity building initiative with the goal of ...

  12. Consensus on Training and Implementation of Enhanced Recovery After Surgery

    DEFF Research Database (Denmark)

    Francis, Nader K; Walker, Thomas; Carter, Fiona

    2018-01-01

    ERAS programmes. Teaching modalities exist, but there remains no agreement regarding the optimal training curriculum or how its effectiveness is assessed. We aimed to draw consensus from an expert panel regarding the successful training and implementation of ERAS. METHODS: A modified Delphi technique...... and the structure of training courses; (2) the optimal framework for successful implementation and audit of ERAS including a guide for data collection; (3) a framework to assess the effectiveness of training; (4) criteria to define ERAS training centres of excellence. RESULTS: An ERAS training course must cover...... the evidence-based principles of ERAS with team-oriented training. Successful implementation requires strong leadership, an ERAS facilitator and an effective MDT. Effectiveness of training can be measured by improved compliance. A training centre of excellence should show a willingness to teach...

  13. Realization of Electronically Tunable Current- Mode Multiphase Sinusoidal Oscillators Using CFTAs

    OpenAIRE

    Prungsak Uttaphut

    2012-01-01

    An implementation of current-mode multiphase sinusoidal oscillators is presented. Using CFTA-based lossy integrators, odd and odd/even phase systems can be realized with following advantages. The condition of oscillation and frequency of oscillation can be orthogonally tuned. The high output impedances facilitate easy driving an external load without additional current buffers. The proposed MSOs provide odd or even phase signals that are equally spaced in phase and equal amplitude. The circui...

  14. SIP Signaling Implementations and Performance Enhancement over MANET: A Survey

    OpenAIRE

    Alshamrani, M; Cruickshank, Haitham; Sun, Zhili; Ansa, G; Alshahwan, F

    2016-01-01

    The implementation of the Session Initiation Protocol (SIP)-based Voice over Internet Protocol (VoIP) and multimedia over MANET is still a challenging issue. Many routing factors affect the performance of SIP signaling and the voice Quality of Service (QoS). Node mobility in MANET causes dynamic changes to route calculations, topology, hop numbers, and the connectivity status between the correspondent nodes. SIP-based VoIP depends on the caller’s registration, call initiation, and call termin...

  15. Sensorless optimal sinusoidal brushless direct current for hard disk drives

    Science.gov (United States)

    Soh, C. S.; Bi, C.

    2009-04-01

    Initiated by the availability of digital signal processors and emergence of new applications, market demands for permanent magnet synchronous motors have been surging. As its back-emf is sinusoidal, the drive current should also be sinusoidal for reducing the torque ripple. However, in applications like hard disk drives, brushless direct current (BLDC) drive is adopted instead of sinusoidal drive for simplification. The adoption, however, comes at the expense of increased harmonics, losses, torque pulsations, and acoustics. In this paper, we propose a sensorless optimal sinusoidal BLDC drive. First and foremost, the derivation for an optimal sinusoidal drive is presented, and a power angle control scheme is proposed to achieve an optimal sinusoidal BLDC. The scheme maintains linear relationship between the motor speed and drive voltage. In an attempt to execute the sensorless drive, an innovative power angle measurement scheme is devised, which takes advantage of the freewheeling diodes and measures the power angle through the detection of diode voltage drops. The objectives as laid out will be presented and discussed in this paper, supported by derivations, simulations, and experimental results. The proposed scheme is straightforward, brings about the benefits of sensorless sinusoidal drive, negates the need for current sensors by utilizing the freewheeling diodes, and does not incur additional cost.

  16. An experimental study on flow friction and heat transfer of water in sinusoidal wavy silicon microchannels

    Science.gov (United States)

    Huang, Houxue; Wu, Huiying; Zhang, Chi

    2018-05-01

    Sinusoidal wavy microchannels have been known as a more heat transfer efficient heat sink for the cooling of electronics than normal straight microchannels. However, the existing experimental study on wavy silicon microchannels with different phase differences are few. As a result of this, in this paper an experimental study has been conducted to investigate the single phase flow friction and heat transfer of de-ionized water in eight different sinusoidal wavy silicon microchannels (SWSMCs) and one straight silicon microchannel (SMC). The SWSMCs feature different phase differences (α  =  0 to π) and different relative wavy amplitudes (β  =  A/l  =  0.05 to 0.4), but the same average hydraulic diameters (D h  =  160 µm). It is found that both flow friction constant fRe and the Nusselt number depend on the phase difference and relative wavy amplitude. For sinusoidal wavy microchannels with a relative wavy amplitude (β  =  0.05), the Nusselt number increased noticeably with the phase difference for Re  >  250, but the effect was insignificant for Re  reducing the wavy wave length induced higher pressure drop and apparent friction constant fRe, while the Nusselt number increased with relative wavy amplitude for Re  >  300. The results indicate that the thermal resistances of sinusoidal wavy silicon microchannels were generally lower than that of straight silicon microchannels, and the thermal resistance decreased with the increase in relative wavy amplitude. The enhancement of thermal performance is attributed to the flow re-circulation occurring in the corrugation troughs and the secondary flows or Dean vortices introduced by curved channels. It is concluded that silicon sinusoidal wavy microchannels provide higher heat transfer rate albeit with a higher flow friction, making it a better choice for the cooling of high heat flux electronics.

  17. Defibrotide: An Oligonucleotide for Sinusoidal Obstruction Syndrome.

    Science.gov (United States)

    Aziz, May T; Kakadiya, Payal P; Kush, Samantha M; Weigel, Kylie; Lowe, Denise K

    2018-02-01

    To review the efficacy and safety of defibrotide as well as its pharmacology, mechanism of action, pharmacokinetics (PK), drug-drug interactions, dosing, cost considerations, and place in therapy. A PubMed search was performed through August 2017 using the terms defibrotide, oligonucleotide, hepatic veno-occlusive disease (VOD), sinusoidal obstruction syndrome (SOS), and hematopoietic cell transplantation (HCT). Other data sources were from references of identified studies, review articles, and conference abstracts plus manufacturer product labeling and website, the Food and Drug Administration website, and clinicaltrials.gov. English-language trials that examined defibrotide's pharmacodynamics, mechanism, PK, efficacy, safety, dosing, and cost-effectiveness were included. Trials have confirmed the safety and efficacy of defibrotide for treatment of VOD/SOS in adult and pediatric HCT patients, with complete response rates and day +100 overall survival rates ranging from 25.5% to 76% and 35% to 64%, respectively. The British Committee for Standards in Haematology/British Society for Blood and Marrow Transplantation Guidelines recommend defibrotide prophylaxis in pediatric and adult HCT patients with risk factors for VOD/SOS; however, its prophylactic use in the United States is controversial. Although there are efficacy data to support this strategy, cost-effectiveness data have not shown it to be cost-effective. Defibrotide has manageable toxicities, with low rates of grade 3 to 4 adverse effects. Defibrotide is the first medication approved in the United States for the treatment of adults and children with hepatic VOD/SOS, with renal or pulmonary dysfunction following HCT. Data evaluating defibrotide for VOD/SOS prevention are conflicting and have not shown cost-effectiveness.

  18. Sinusoidal Analysis-Synthesis of Audio Using Perceptual Criteria

    Science.gov (United States)

    Painter, Ted; Spanias, Andreas

    2003-12-01

    This paper presents a new method for the selection of sinusoidal components for use in compact representations of narrowband audio. The method consists of ranking and selecting the most perceptually relevant sinusoids. The idea behind the method is to maximize the matching between the auditory excitation pattern associated with the original signal and the corresponding auditory excitation pattern associated with the modeled signal that is being represented by a small set of sinusoidal parameters. The proposed component-selection methodology is shown to outperform the maximum signal-to-mask ratio selection strategy in terms of subjective quality.

  19. Design and Implementation of Enhanced Smart Energy Metering System

    Directory of Open Access Journals (Sweden)

    Oday A.L.A Ridha

    2017-03-01

    Full Text Available In this work, the design and implementation of a smart energy metering system has been developed. This system consists of two parts: billing center and a set of distributed smart energy meters. The function of smart energy meter is measuring and calculating the cost of consumed energy according to a multi-tariff scheme. This can be effectively solving the problem of stressing the electrical grid and rising consumer awareness. Moreover, smart energy meter decreases technical losses by improving power factor. The function of the billing center is to issue a consumer bill and contributes in locating the irregularities on the electrical grid (non-technical losses. Moreover, it sends the switch off command in case of the consumer bill is not paid. For implementation of smart energy meter, the microcontroller (PIC 18F45K22 is used. For communication between billing center and smart energy meters, ZigBee technology is adopted. The necessary program for smart energy meter is written in MicroC PRO, while the program for billing center is written in visual C#.

  20. Implementing digital technology to enhance student learning of pathology.

    Science.gov (United States)

    Farah, C S; Maybury, T

    2009-08-01

    The introduction of digital technologies into the dental curriculum is an ongoing feature of broader changes going on in tertiary education. This report examines the introduction of digital virtual microscopy technology into the curriculum of the School of Dentistry at the University of Queensland (UQ) in Brisbane, Australia. Sixty students studying a course in pathology in 2005 were introduced to virtual microscopy technology alongside the more traditional light microscope and then asked to evaluate their own learning outcomes from this technology via a structured 5-point LIKART survey. A wide variety of questions dealing the pedagogic implications of the introduction of virtual microscopy into pathology were asked of students with the overall result being that it positively enhanced their learning of pathology via digital microscopic means. The success of virtual microscopy in dentistry at UQ is then discussed in the larger context of changes going on in tertiary education. In particular, the change from the print-literate tradition to the electronic one, that is from 'literacy to electracy'. Virtual microscopy is designated as a component of this transformation to electracy. Whilst traditional microscopic skills may still be valued in dental curricula, the move to virtual microscopy and computer-assisted, student-centred learning of pathology appears to enhance the learning experience in relation to its effectiveness in helping students engage and interact with the course material.

  1. Adaptive Feedforward Cancellation of Sinusoidal Disturbances in Superconducting RF Cavities

    CERN Document Server

    Kandil, T H; Hartung, W; Khalil, H; Popielarski, J; Vincent, J; York, R C

    2004-01-01

    A control method, known as adaptive feedforward cancellation (AFC) is applied to damp sinusoidal disturbances due to microphonics in superconducting RF (SRF) cavities. AFC provides a method for damping internal, and external sinusoidal disturbances with known frequencies. It is preferred over other schemes because it uses rudimentary information about the frequency response at the disturbance frequencies, without the necessity of knowing an analytic model (transfer function) of the system. It estimates the magnitude and phase of the sinusoidal disturbance inputs and generates a control signal to cancel their effect. AFC, along with a frequency estimation process, is shown to be very successful in the cancellation of sinusoidal signals from different sources. The results of this research may significantly reduce the power requirements and increase the stability for lightly loaded continuous-wave SRF systems.

  2. Asymptotic Theory of the Least Squares Estimators of Sinusoidal Signal

    National Research Council Canada - National Science Library

    Kundu, Debasis

    1997-01-01

    ... normality are derived for the sinusoidal signal under the assumption of normal error (Kundu; 1993) and under the assumptions of independent and identically distributed random variables in Kundu and Mitra...

  3. Converter for Measurement of non-sinusoidal current peak value

    DEFF Research Database (Denmark)

    Butvin, P.; Nielsen, Otto V; Brauer, Peter

    1997-01-01

    A linear-response toroid with core wound of rapidly quenched soft magnetic metallic ribbon and fitted with two windings is used to enable correct measurement of mean peak value of non-sinusoidal and not noise-free alternating current.......A linear-response toroid with core wound of rapidly quenched soft magnetic metallic ribbon and fitted with two windings is used to enable correct measurement of mean peak value of non-sinusoidal and not noise-free alternating current....

  4. Privacy Enhancing Keyboard: Design, Implementation, and Usability Testing

    Directory of Open Access Journals (Sweden)

    Zhen Ling

    2017-01-01

    Full Text Available To protect users from numerous password inference attacks, we invent a novel context aware privacy enhancing keyboard (PEK for Android touch-based devices. Usually PEK would show a QWERTY keyboard when users input text like an email or a message. Nevertheless, whenever users enter a password in the input box on his or her touch-enabled device, a keyboard will be shown to them with the positions of the characters shuffled at random. PEK has been released on the Google Play since 2014. However, the number of installations has not lived up to our expectation. For the purpose of usable security and privacy, we designed a two-stage usability test and performed two rounds of iterative usability testing in 2016 and 2017 summer with continuous improvements of PEK. The observations from the usability testing are educational: (1 convenience plays a critical role when users select an input method; (2 people think those attacks that PEK prevents are remote from them.

  5. Analysis of Passive Mixing in a Serpentine Microchannel with Sinusoidal Side Walls

    Directory of Open Access Journals (Sweden)

    Muhammad Usman Javaid

    2017-12-01

    Full Text Available Sample mixing is difficult in microfluidic devices because of laminar flow. Micromixers are designed to ensure the optimal use of miniaturized devices. The present study aims to design a chaotic-advection-based passive micromixer with enhanced mixing efficiency. A serpentine-shaped microchannel with sinusoidal side walls was designed, and three cases, with amplitude to wavelength (A/λ ratios of 0.1, 0.15, and 0.2 were investigated. Numerical simulations were conducted using the Navier–Stokes equations, to determine the flow field. The flow was then coupled with the convection–diffusion equation to obtain the species concentration distribution. The mixing performance of sinusoidal walled channels was compared with that of a simple serpentine channel for Reynolds numbers ranging from 0.1 to 50. Secondary flows were observed at high Reynolds numbers that mixed the fluid streams. These flows were dominant in the proposed sinusoidal walled channels, thereby showing better mixing performance than the simple serpentine channel at similar or less mixing cost. Higher mixing efficiency was obtained by increasing the A/λ ratio.

  6. Bottomside sinusoidal irregularities in the equatorial F region

    Science.gov (United States)

    Valladares, C. E.; Hanson, W. B.; Mcclure, J. P.; Cragin, B. L.

    1983-01-01

    By using the Ogo 6 satellite, McClure and Hanson (1973) have discovered sinusoidal irregularities in the equatorial F region ion number density. In the present investigation, a description is provided of the properties of a distinct category of sinusoidal irregularities found in equatorial data from the AE-C and AE-E satellites. The observed scale sizes vary from about 300 m to 3 km in the direction perpendicular to B, overlapping with and extending the range observed by using Ogo 6. Attention is given to low and high resolution data, a comparison with Huancayo ionograms, the confinement of 'bottomside sinusoidal' (BSS) irregularities essentially to the bottomside of the F layer, spectral characteristics, and BSS, scintillation, and ionosonde observations.

  7. Influence of the Periodicity of Sinusoidal Boundary Condition on the Unsteady Mixed Convection within a Square Enclosure Using an Ag–Water Nanofluid

    Directory of Open Access Journals (Sweden)

    Azharul Karim

    2017-12-01

    Full Text Available A numerical study of the unsteady mixed convection heat transfer characteristics of an Ag–water nanofluid confined within a square shape lid-driven cavity has been carried out. The Galerkin weighted residual of the finite element method has been employed to investigate the effects of the periodicity of sinusoidal boundary condition for a wide range of Grashof numbers (Gr (105 to 107 with the parametric variation of sinusoidal even and odd frequency, N, from 1 to 6 at different instants (for τ = 0.1 and 1. It has been observed that both the Grashof number and the sinusoidal even and odd frequency have a significant influence on the streamlines and isotherms inside the cavity. The heat transfer rate enhanced by 90% from the heated surface as the Grashof number (Gr increased from 105 to 107 at sinusoidal frequency N = 1 and τ = 1.

  8. Some New Results on the Estimation of Sinusoids in Noise

    DEFF Research Database (Denmark)

    Nielsen, Jesper Kjær

    2012-01-01

    This thesis is concerned with the problem of estimating sinusoidal parameters from noisy observations. This field of research is applicable to solving problems in a large number of areas such as music and speech processing, electrocardiography, seismology, radar and sonar processing, astronomy....... Third, an efficient algorithm for performing inference and interpolation in a dynamic sinusoidal model is proposed. This method is applied to packet-loss concealment, and listening tests indicate that the proposed algorithm can be used for this purpose. Fourth, the Capon filtering method for amplitude...

  9. CNNs for sinusoidal signal recognition in hearing rehabilitation

    Science.gov (United States)

    Carnimeo, Leonarda; Giaquinto, Antonio

    2003-04-01

    In this paper, a contribution is given to provide a tool to the recognition of sinusoidal signals with a particular reference to the field of pediatric hearing rehabilitation. To this purpose, a synthesis technique previously developed by the authors' is used to design a Cellular Neural Network for an Associative Memory able to compare submitted discrete-time sinusoidal signals with memorized ones. A robustness analysis of the synthesized associative memory is also developed both for noisy inputs and for parameter variations. Simulation results are then reported to illustrate the performances of the designed network.

  10. How can online communication enhance older adults’ social connectivity? : Implementation and adoption issues

    NARCIS (Netherlands)

    Hage, Maria Louisa

    2015-01-01

    It is often assumed online communication can enhance older adults’ social connectivity. However, previous studies have indicated two obstacles. First, older adults tend to be late adopters, or laggards. This raises the question how online communication tools can be implemented among a population

  11. Generation of hyperchaos from the Chen-Lee system via sinusoidal perturbation

    Energy Technology Data Exchange (ETDEWEB)

    Tam, L.M. [Department of Electromechanical Engineering, Faculty of Science and Technology, University of Macau, Av. Padre Thomas Pereira S.J., Taipa, Macau (China)], E-mail: fstlmt@umac.mo; Chen, J.H. [Department of Mechanical Engineering, Chung Hua University, Hsinchu, Taiwan (China); Chen, H.K. [Department of Mechanical Engineering, Hsiuping Institute of Technology, Taichung, Taiwan (China); Wai Meng Si Tou [Department of Electromechanical Engineering, Faculty of Science and Technology, University of Macau, Av. Padre Thomas Pereira S.J., Taipa, Macau (China)

    2008-11-15

    A system with more than one positive Lyapunov exponent can be classified as a hyperchaotic system. In this study, a sinusoidal perturbation was designed for generating hyperchaos from the Chen-Lee chaotic system. The hyperchaos was identified by the existence of two positive Lyapunov exponents and bifurcation diagrams. The system is hyperchaotic in several different regions of the parameters c, {epsilon}, and {omega}. It was found that this method not only can enhance or suppress chaotic behavior, but also induces chaos in non-chaotic parameter ranges. In addition, two interesting dynamical behaviors, Hopf bifurcation and intermittency, were also found in this study.

  12. Generation of hyperchaos from the Chen-Lee system via sinusoidal perturbation

    International Nuclear Information System (INIS)

    Tam, L.M.; Chen, J.H.; Chen, H.K.; Wai Meng Si Tou

    2008-01-01

    A system with more than one positive Lyapunov exponent can be classified as a hyperchaotic system. In this study, a sinusoidal perturbation was designed for generating hyperchaos from the Chen-Lee chaotic system. The hyperchaos was identified by the existence of two positive Lyapunov exponents and bifurcation diagrams. The system is hyperchaotic in several different regions of the parameters c, ε, and ω. It was found that this method not only can enhance or suppress chaotic behavior, but also induces chaos in non-chaotic parameter ranges. In addition, two interesting dynamical behaviors, Hopf bifurcation and intermittency, were also found in this study

  13. Trans-sinusoidal maxillary distraction in three cleft patients.

    NARCIS (Netherlands)

    Wenghoefer, M.H.; Martini, M.; Nadjmi, N.; Schutyser, F.A.C.; Jagtman, A.K.; Bergé, S.J.

    2006-01-01

    The trans-sinusoidal maxillary distractor (TS-MD) was used to achieve maxillary advancement in three patients with repaired cleft lip and palate. After preoperative computer-aided planning of the distraction vectors, each TS-MD was bent on a stereolithographic model of the maxilla of the patient.

  14. Sinusoidal velaroidal shell – numerical modelling of the nonlinear ...

    African Journals Online (AJOL)

    The nonlinearity, applied to a sinusoidal velaroidal shell with the inner radius r0, the outer variables radii from 10m to 20m and the number of waves n=8, will give rise to the investigation of its nonlinear buckling resistance. The building material is a high-performant concrete. The investigation emphasizes more on the ...

  15. Optimization for sinusoidal profiles in surface relief gratings ...

    Indian Academy of Sciences (India)

    2014-02-07

    Feb 7, 2014 ... filometry [7–9] and monitoring of surface self-diffusion of solids under ultrahigh vacuum conditions [10]. In the present work, recording parameters, i.e. exposure time and deve- lopment time for fabrication of such holographic gratings have been optimized to obtain nearly perfect sinusoidal profiles in the ...

  16. Evoked responses to sinusoidally modulated sound in unanaesthetized dogs

    NARCIS (Netherlands)

    Tielen, A.M.; Kamp, A.; Lopes da Silva, F.H.; Reneau, J.P.; Storm van Leeuwen, W.

    1. 1. Responses evoked by sinusoidally amplitude-modulated sound in unanaesthetized dogs have been recorded from inferior colliculus and from auditory cortex structures by means of chronically indwelling stainless steel wire electrodes. 2. 2. Harmonic analysis of the average responses demonstrated

  17. Deep-etched sinusoidal polarizing beam splitter grating.

    Science.gov (United States)

    Feng, Jijun; Zhou, Changhe; Cao, Hongchao; Lv, Peng

    2010-04-01

    A sinusoidal-shaped fused-silica grating as a highly efficient polarizing beam splitter (PBS) is investigated based on the simplified modal method. The grating structure depends mainly on the ratio of groove depth to grating period and the ratio of incident wavelength to grating period. These ratios can be used as a guideline for the grating design at different wavelengths. A sinusoidal-groove PBS grating is designed at a wavelength of 1310 nm under Littrow mounting, and the transmitted TM and TE polarized waves are mainly diffracted into the zeroth order and the -1st order, respectively. The grating profile is optimized by using rigorous coupled-wave analysis. The designed PBS grating is highly efficient (>95.98%) over the O-band wavelength range (1260-1360 nm) for both TE and TM polarizations. The sinusoidal grating can exhibit higher diffraction efficiency, larger extinction ratio, and less reflection loss than the rectangular-groove PBS grating. By applying wet etching technology on the rectangular grating, which was manufactured by holographic recording and inductively coupled plasma etching technology, the sinusoidal grating can be approximately fabricated. Experimental results are in agreement with theoretical values.

  18. Using piecewise sinusoidal basis functions to blanket multiple wire segments

    CSIR Research Space (South Africa)

    Lysko, AA

    2009-06-01

    Full Text Available This paper discusses application of the piecewise sinusoidal (PWS) basis function (BF) over a chain of several wire segments, for example as a multiple domain basis function. The usage of PWS BF is compared to results based on the piecewise linear...

  19. Pelagic behaviour of reservoir fishes: sinusoidal swimming and associated behaviour

    OpenAIRE

    JAROLÍM, Oldřich

    2009-01-01

    Annotation Long-term fixed-location hydroacoustic study with uplooking transducer was performed during 2005 in Římov reservoir, Czech Republic. It dealt mainly with fish behaviour in the open water of reservoir, especially with sinusoidal swimming behaviour. The dependence of pelagic fish behaviour on environmental conditions was also studied.

  20. BPM Offset Determination by Sinusoidal Quadrupole K-modulation

    CERN Document Server

    Baer, T; Wenninger, J

    2011-01-01

    To ensure an adequate orbit steering that maximizes the machine aperture, a good knowledge of the BPM measurement offsets is crucial. During this MD, a sinusoidal k-modulation of individually powered quadrupoles was performed to determine the offsets of the nearby BPMs. An accuracy of 10µm for the determination of the absolute beam position is reached.

  1. 3D hepatic cultures simultaneously maintain primary hepatocyte and liver sinusoidal endothelial cell phenotypes.

    Directory of Open Access Journals (Sweden)

    Yeonhee Kim

    Full Text Available Developing in vitro engineered hepatic tissues that exhibit stable phenotype is a major challenge in the field of hepatic tissue engineering. However, the rapid dedifferentiation of hepatic parenchymal (hepatocytes and non-parenchymal (liver sinusoidal endothelial, LSEC cell types when removed from their natural environment in vivo remains a major obstacle. The primary goal of this study was to demonstrate that hepatic cells cultured in layered architectures could preserve or potentially enhance liver-specific behavior of both cell types. Primary rat hepatocytes and rat LSECs (rLSECs were cultured in a layered three-dimensional (3D configuration. The cell layers were separated by a chitosan-hyaluronic acid polyelectrolyte multilayer (PEM, which served to mimic the Space of Disse. Hepatocytes and rLSECs exhibited several key phenotypic characteristics over a twelve day culture period. Immunostaining for the sinusoidal endothelial 1 antibody (SE-1 demonstrated that rLSECs cultured in the 3D hepatic model maintained this unique feature over twelve days. In contrast, rLSECs cultured in monolayers lost their phenotype within three days. The unique stratified structure of the 3D culture resulted in enhanced heterotypic cell-cell interactions, which led to improvements in hepatocyte functions. Albumin production increased three to six fold in the rLSEC-PEM-Hepatocyte cultures. Only rLSEC-PEM-Hepatocyte cultures exhibited increasing CYP1A1/2 and CYP3A activity. Well-defined bile canaliculi were observed only in the rLSEC-PEM-Hepatocyte cultures. Together, these data suggest that rLSEC-PEM-Hepatocyte cultures are highly suitable models to monitor the transformation of toxins in the liver and their transport out of this organ. In summary, these results indicate that the layered rLSEC-PEM-hepatocyte model, which recapitulates key features of hepatic sinusoids, is a potentially powerful medium for obtaining comprehensive knowledge on liver metabolism

  2. A protocol is not enough to implement an enhanced recovery programme for colorectal resection

    DEFF Research Database (Denmark)

    Maessen, J; Dejong, C.H.C.; Hausel, J

    2007-01-01

    BACKGROUND: Single-centre studies have suggested that enhanced recovery can be achieved with multimodal perioperative care protocols. This international observational study evaluated the implementation of an enhanced recovery programme in five European centres and examined the determinants...... with a shorter hospital stay. CONCLUSION: Functional recovery in 3 days after colorectal resection could be achieved in daily practice. A protocol is not enough to enable discharge of patients on the day of functional recovery; more experience and better organization of care may be required. Copyright (c) 2006...

  3. Efficient Hardware Implementation For Fingerprint Image Enhancement Using Anisotropic Gaussian Filter.

    Science.gov (United States)

    Khan, Tariq Mahmood; Bailey, Donald G; Khan, Mohammad A U; Kong, Yinan

    2017-05-01

    A real-time image filtering technique is proposed which could result in faster implementation for fingerprint image enhancement. One major hurdle associated with fingerprint filtering techniques is the expensive nature of their hardware implementations. To circumvent this, a modified anisotropic Gaussian filter is efficiently adopted in hardware by decomposing the filter into two orthogonal Gaussians and an oriented line Gaussian. An architecture is developed for dynamically controlling the orientation of the line Gaussian filter. To further improve the performance of the filter, the input image is homogenized by a local image normalization. In the proposed structure, for a middle-range reconfigurable FPGA, both parallel compute-intensive and real-time demands were achieved. We manage to efficiently speed up the image-processing time and improve the resource utilization of the FPGA. Test results show an improved speed for its hardware architecture while maintaining reasonable enhancement benchmarks.

  4. A Framework for Enhancing the Value of Research for Dissemination and Implementation.

    Science.gov (United States)

    Neta, Gila; Glasgow, Russell E; Carpenter, Christopher R; Grimshaw, Jeremy M; Rabin, Borsika A; Fernandez, Maria E; Brownson, Ross C

    2015-01-01

    A comprehensive guide that identifies critical evaluation and reporting elements necessary to move research into practice is needed. We propose a framework that highlights the domains required to enhance the value of dissemination and implementation research for end users. We emphasize the importance of transparent reporting on the planning phase of research in addition to delivery, evaluation, and long-term outcomes. We highlight key topics for which well-established reporting and assessment tools are underused (e.g., cost of intervention, implementation strategy, adoption) and where such tools are inadequate or lacking (e.g., context, sustainability, evolution) within the context of existing reporting guidelines. Consistent evaluation of and reporting on these issues with standardized approaches would enhance the value of research for practitioners and decision-makers.

  5. The sinusoidal lining cells in "normal" human liver. A scanning electron microscopic investigation

    DEFF Research Database (Denmark)

    Horn, T; Henriksen, Jens Henrik Sahl; Christoffersen, P

    1986-01-01

    The scanning electron microscopic was used to study the fenestrations of human liver sinusoids. Thirteen biopsies, where light microscopy and transmission electron microscopy revealed normal sinusoidal architecture, were investigated. The number of fenestrae was calculated in acinar zone 3...

  6. Unified design of sinusoidal-groove fused-silica grating.

    Science.gov (United States)

    Feng, Jijun; Zhou, Changhe; Cao, Hongchao; Lu, Peng

    2010-10-20

    A general design rule of deep-etched subwavelength sinusoidal-groove fused-silica grating as a highly efficient polarization-independent or polarization-selective device is studied based on the simplified modal method, which shows that the device structure depends little on the incident wavelength, but mainly on the ratio of groove depth to incident wavelength and the ratio of wavelength to grating period. These two ratios could be used as the design guidelines for wavelength-independent structure from deep ultraviolet to far infrared. The optimized grating profile with a different function as a polarizing beam splitter, a polarization-independent two-port beam splitter, or a polarization-independent grating with high efficiency of -1st order is obtained at a wavelength of 1064 nm, and verified by using the rigorous coupled-wave analysis. The performance of the sinusoidal grating is better than a conventional rectangular one, which could be useful for practical applications.

  7. Investigation of Calibrating Force Transducer Using Sinusoidal Force

    International Nuclear Information System (INIS)

    Zhang Li; Wang Yu; Zhang Lizhe

    2010-01-01

    Sinusoidal force calibration method was studied several years before at Physikalisch-Technische Bundesanstalt (PTB). A similar dynamic force calibration system is developed at Changcheng Institute of Metrology and Measurement (CIMM). It uses electro-dynamic shakers to generate dynamic force in the range from 1 N to 20 kN, and heterodyne laser interferometers are used for acceleration measurement. The force transducer to be calibrated is mounted on the shaker, and a mass block is screwed on the top of force transducer, the sinusoidal forces realized by accelerated load masses are traceable to acceleration and mass according to the force definition. The methods of determining Spatial-dependent acceleration on mass block and measuring the end mass of force transducer in dynamic force calibration are discussed in this paper.

  8. Electric stimulation with sinusoids and white noise for neural prostheses

    Directory of Open Access Journals (Sweden)

    Daniel K Freeman

    2010-02-01

    Full Text Available We are investigating the use of novel stimulus waveforms in neural prostheses to determine whether they can provide more precise control over the temporal and spatial pattern of elicited activity as compared to conventional pulsatile stimulation. To study this, we measured the response of retinal ganglion cells to both sinusoidal and white noise waveforms. The use of cell-attached and whole cell patch clamp recordings allowed the responses to be observed without significant obstruction from the stimulus artifact. Electric stimulation with sinusoids elicited robust responses. White noise analysis was used to derive the linear kernel for the ganglion cell’s spiking response as well as for the underlying excitatory currents. These results suggest that in response to electric stimulation, presynaptic retinal neurons exhibit bandpass filtering characteristics with peak response that occur 25ms after onset. The experimental approach demonstrated here may be useful for studying the temporal response properties of other neurons in the CNS.

  9. Noise reduction and image enhancement using a hardware implementation of artificial neural networks

    Science.gov (United States)

    David, Robert; Williams, Erin; de Tremiolles, Ghislain; Tannhof, Pascal

    1999-03-01

    In this paper, we present a neural based solution developed for noise reduction and image enhancement using the ZISC, an IBM hardware processor which implements the Restricted Coulomb Energy algorithm and the K-Nearest Neighbor algorithm. Artificial neural networks present the advantages of processing time reduction in comparison with classical models, adaptability, and the weighted property of pattern learning. The goal of the developed application is image enhancement in order to restore old movies (noise reduction, focus correction, etc.), to improve digital television images, or to treat images which require adaptive processing (medical images, spatial images, special effects, etc.). Image results show a quantitative improvement over the noisy image as well as the efficiency of this system. Further enhancements are being examined to improve the output of the system.

  10. Increased sinusoidal volume and solute extraction during retrograde liver perfusion

    International Nuclear Information System (INIS)

    Bass, N.M.; Manning, J.A.; Weisiger, R.A.

    1989-01-01

    Retrograde isolated liver perfusion has been used to probe acinar functional heterogeneity, but the hemodynamic effects of backward flow have not been characterized. In this study, extraction of a long-chain fatty acid derivative, 12-N-methyl-7-nitrobenzo-2-oxa-1,3-diazol-amino stearate (12-NBDS), was greater during retrograde than during anterograde perfusion of isolated rat liver. To determine whether hemodynamic differences between anterograde and retrograde perfused livers could account for this finding, the hepatic extracellular space was measured for both directions of flow by means of [ 14 C]sucrose washout during perfusion as well as by direct measurement of [ 14 C]sucrose entrapped during perfusion. A three- to fourfold enlargement of the total hepatic extracellular space was found during retrograde perfusion by both approaches. Examination of perfusion-fixed livers by light microscopy and morphometry revealed that marked distension of the sinusoids occurred during retrograde perfusion and that this accounts for the observed increase in the [ 14 C]sucrose space. These findings support the hypothesis that maximum resistance to perfusate flow in the isolated perfused rat liver is located at the presinusoidal level. In addition, increased transit time of perfusate through the liver and greater sinusoidal surface area resulting from sinusoidal distension may account for the higher extraction of 12-NBDS and possibly other compounds by retrograde perfused liver

  11. Dietary macronutrients and the aging liver sinusoidal endothelial cell.

    Science.gov (United States)

    Cogger, Victoria Carroll; Mohamad, Mashani; Solon-Biet, Samantha Marie; Senior, Alistair M; Warren, Alessandra; O'Reilly, Jennifer Nicole; Tung, Bui Thanh; Svistounov, Dmitri; McMahon, Aisling Clare; Fraser, Robin; Raubenheimer, David; Holmes, Andrew J; Simpson, Stephen James; Le Couteur, David George

    2016-05-01

    Fenestrations are pores within the liver sinusoidal endothelial cells (LSECs) that line the sinusoids of the highly vascularized liver. Fenestrations facilitate the transfer of substrates between blood and hepatocytes. With pseudocapillarization of the hepatic sinusoid in old age, there is a loss of fenestrations. LSECs are uniquely exposed to gut-derived dietary and microbial substrates delivered by the portal circulation to the liver. Here we studied the effect of 25 diets varying in content of macronutrients and energy on LSEC fenestrations using the Geometric Framework method in a large cohort of mice aged 15 mo. Macronutrient distribution rather than total food or energy intake was associated with changes in fenestrations. Porosity and frequency were inversely associated with dietary fat intake, while fenestration diameter was inversely associated with protein or carbohydrate intake. Fenestrations were also linked to diet-induced changes in gut microbiome, with increased fenestrations associated with higher abundance of Firmicutes and reduced abundance of Bacteroidetes Diet-induced changes in levels of several fatty acids (C16:0, C19:0, and C20:4) were also significantly inversely associated with fenestrations, suggesting a link between dietary fat and modulation of lipid rafts in the LSECs. Diet influences fenestrations and these data reflect both the key role of the LSECs in clearing gut-derived molecules from the vascular circulation and the impact these molecules have on LSEC morphology. Copyright © 2016 the American Physiological Society.

  12. Implementation of Enhanced Recovery After Surgery: a strategy to transform surgical care across a health system.

    Science.gov (United States)

    Gramlich, Leah M; Sheppard, Caroline E; Wasylak, Tracy; Gilmour, Loreen E; Ljungqvist, Olle; Basualdo-Hammond, Carlota; Nelson, Gregg

    2017-05-19

    Enhanced Recovery After Surgery (ERAS) programs have been shown to have a positive impact on outcome. The ERAS care system includes an evidence-based guideline, an implementation program, and an interactive audit system to support practice change. The purpose of this study is to describe the use of the Theoretic Domains Framework (TDF) in changing surgical care and application of the Quality Enhancement Research Initiative (QUERI) model to analyze end-to-end implementation of ERAS in colorectal surgery across multiple sites within a single health system. The ultimate intent of this work is to allow for the development of a model for spread, scale, and sustainability of ERAS in Alberta Health Services (AHS). ERAS for colorectal surgery was implemented at two sites and then spread to four additional sites. The ERAS Interactive Audit System (EIAS) was used to assess compliance with the guidelines, length of stay, readmissions, and complications. Data sources informing knowledge translation included surveys, focus groups, interviews, and other qualitative data sources such as minutes and status updates. The QUERI model and TDF were used to thematically analyze 189 documents with 2188 quotes meeting the inclusion criteria. Data sources were analyzed for barriers or enablers, organized into a framework that included individual to organization impact, and areas of focus for guideline implementation. Compliance with the evidence-based guidelines for ERAS in colorectal surgery at baseline was 40%. Post implementation compliance, consistent with adoption of best practice, improved to 65%. Barriers and enablers were categorized as clinical practice (22%), individual provider (26%), organization (19%), external environment (7%), and patients (25%). In the Alberta context, 26% of barriers and enablers to ERAS implementation occurred at the site and unit levels, with a provider focus 26% of the time, a patient focus 26% of the time, and a system focus 22% of the time. Using the

  13. Diffraction Efficiency Testing of Sinusoidal and Blazed Off-Plane Reflection Gratings

    Science.gov (United States)

    Tutt, James H.; McEntaffer, Randall L.; Marlowe, Hannah; Miles, Drew M.; Peterson, Thomas J.; Deroo, Casey T.; Scholze, Frank; Laubis, Christian

    2016-09-01

    Reflection gratings in the off-plane mount have the potential to enhance the performance of future high resolution soft X-ray spectrometers. Diffraction efficiency can be optimized through the use of blazed grating facets, achieving high-throughput on one side of zero-order. This paper presents the results from a comparison between a grating with a sinusoidally grooved profile and two gratings that have been blazed. The results show that the blaze does increase throughput to one side of zero-order; however, the total throughput of the sinusoidal gratings is greater than the blazed gratings, suggesting the method of manufacturing the blazed gratings does not produce precise facets. The blazed gratings were also tested in their Littrow and anti-Littrow configurations to quantify diffraction efficiency sensitivity to rotations about the grating normal. Only a small difference in the energy at which efficiency is maximized between the Littrow and anti-Littrow configurations is seen with a small shift in peak efficiency towards higher energies in the anti-Littrow case. This is due to a decrease in the effective blaze angle in the anti-Littrow mounting. This is supported by PCGrate-SX V6.1 modeling carried out for each blazed grating which predicts similar response trends in the Littrow and anti-Littrow orientations.

  14. Enhanced primary mental healthcare for Indigenous Australians: service implementation strategies and perspectives of providers.

    Science.gov (United States)

    Reifels, Lennart; Nicholas, Angela; Fletcher, Justine; Bassilios, Bridget; King, Kylie; Ewen, Shaun; Pirkis, Jane

    2018-01-01

    Improving access to culturally appropriate mental healthcare has been recognised as a key strategy to address the often greater burden of mental health issues experienced by Indigenous populations. We present data from the evaluation of a national attempt at improving access to culturally appropriate mental healthcare for Indigenous Australians through a mainstream primary mental healthcare program, the Access to Allied Psychological Services program, whilst specifically focusing on the implementation strategies and perspectives of service providers. We conducted semi-structured interviews with 31 service providers (primary care agency staff, referrers, and mental health professionals) that were analysed thematically and descriptively. Agency-level implementation strategies to enhance service access and cultural appropriateness included: the conduct of local service needs assessments; Indigenous stakeholder consultation and partnership development; establishment of clinical governance frameworks; workforce recruitment, clinical/cultural training and supervision; stakeholder and referrer education; and service co-location at Indigenous health organisations. Dedicated provider-level strategies to ensure the cultural appropriateness of services were primarily aimed at the context and process of delivery (involving, flexible referral pathways, suitable locations, adaptation of client engagement and service feedback processes) and, to a lesser extent, the nature and content of interventions (provision of culturally adapted therapy). This study offers insights into key factors underpinning the successful national service implementation approach. Study findings highlight that concerted national attempts to enhance mainstream primary mental healthcare for Indigenous people are critically dependent on effective local agency- and provider-level strategies to optimise the integration, adaptation and broader utility of these services within local Indigenous community and

  15. Does training managers enhance the effects of implementing teamworking? A longitudinal, mixed methods field study

    DEFF Research Database (Denmark)

    Nielsen, Karina; Randall, R; Christensen, KB

    2010-01-01

    , transformational leadership and change management on the outcomes of team implementation. We used a combination of quantitative and qualitative research methods to isolate the impact of manager training on the success of the teamwork intervention. The results identified some significant, but modest, incremental......The introduction of team-working often has positive effects on team members but places significant new demands on managers. Unfortunately, little research has examined whether the impact of the intervention may be enhanced by providing managers with training during the change process. To test...

  16. Sinusoidal modulation analysis for optical system MTF measurements.

    Science.gov (United States)

    Boone, J M; Yu, T; Seibert, J A

    1996-12-01

    The modulation transfer function (MTF) is a commonly used metric for defining the spatial resolution characteristics of imaging systems. While the MTF is defined in terms of how an imaging system demodulates the amplitude of a sinusoidal input, this approach has not been in general use to measure MTFs in the medical imaging community because producing sinusoidal x-ray patterns is technically difficult. However, for optical systems such as charge coupled devices (CCD), which are rapidly becoming a part of many medical digital imaging systems, the direct measurement of modulation at discrete spatial frequencies using a sinusoidal test pattern is practical. A commercially available optical test pattern containing spatial frequencies ranging from 0.375 cycles/mm to 80 cycles/mm was sued to determine the MRF of a CCD-based optical system. These results were compared with the angulated slit method of Fujita [H. Fujita, D. Tsia, T. Itoh, K. Doi, J. Morishita, K. Ueda, and A. Ohtsuka, "A simple method for determining the modulation transfer function in digital radiography," IEEE Trans. Medical Imaging 11, 34-39 (1992)]. The use of a semiautomated profiled iterated reconstruction technique (PIRT) is introduced, where the shift factor between successive pixel rows (due to angulation) is optimized iteratively by least-squares error analysis rather than by hand measurement of the slit angle. PIRT was used to find the slit angle for the Fujita technique and to find the sine-pattern angle for the sine-pattern technique. Computer simulation of PIRT for the case of the slit image (a line spread function) demonstrated that it produced a more accurate angle determination than "hand" measurement, and there is a significant difference between the errors in the two techniques (Wilcoxon Signed Rank Test, p < 0.001). The sine-pattern method and the Fujita slit method produced comparable MTF curves for the CCD camera evaluated.

  17. Propiedades de transporte de una superred de grafeno tipo sinusoidal

    OpenAIRE

    J. A. Briones-Torres; I. Rodríguez-Vargas

    2015-01-01

    En este trabajo usamos el método de la matriz de transferencia para estudiar el tunelamiento de los electrones de Dirac a través de superredes en grafeno. Consideramos una superred con potencial sinusoidal o polaridad invertida, para ello consideramos dos maneras de crearla, una por medio de sustratos mixtos junto con la aplicación de un campo perpendicular sobre el sustrato de Óxido de Silicio (SiO2), la otra por medio de potenciales alternados aplicados perpendicularmente sobre la sábana de...

  18. Ageing monitoring in IGBT module under sinusoidal loading

    DEFF Research Database (Denmark)

    Ghimire, Pramod; Pedersen, Kristian Bonderup; Rannestad, Bjørn

    2015-01-01

    This paper presents monitoring of ageing in high power insulated gate bipolar transistor (IGBT) modules subjected to sinusoidal loading at nominal power level. On-state voltage for IGBT, diode, and rise in interconnection resistance are used as ageing parameters. These are measured in three...... different ways: calibration of power modules after 24 h of operation, offline characterization every 5 min of operation, and continuous measurement during normal converter operation. Four power modules are tested, which are cycled to different degradation levels by number of cycles, where one is tested...

  19. Numerical analysis of beam with sinusoidally corrugated webs

    Science.gov (United States)

    Górecki, Marcin; Pieńko, Michał; Łagoda, GraŻyna

    2018-01-01

    The paper presents numerical tests results of the steel beam with sinusoidally corrugated web, which were performed in the Autodesk Algor Simulation Professional 2010. The analysis was preceded by laboratory tests including the beam's work under the influence of the four point bending as well as the study of material characteristics. Significant web's thickness and use of tools available in the software allowed to analyze the behavior of the plate girder as beam, and also to observe the occurrence of stresses in the characteristic element - the corrugated web. The stress distribution observed on the both web's surfaces was analyzed.

  20. Cost-Benefit Analysis of the Implementation of an Enhanced Recovery Program in Liver Surgery.

    Science.gov (United States)

    Joliat, Gaëtan-Romain; Labgaa, Ismaïl; Hübner, Martin; Blanc, Catherine; Griesser, Anne-Claude; Schäfer, Markus; Demartines, Nicolas

    2016-10-01

    Enhanced recovery after surgery (ERAS) programs have been shown to ease the postoperative recovery and improve clinical outcomes for various surgery types. ERAS cost-effectiveness was demonstrated for colorectal surgery but not for liver surgery. The present study aim was to analyze the implementation costs and benefits of a specific ERAS program in liver surgery. A dedicated ERAS protocol for liver surgery was implemented in our department in July 2013. The subsequent year all consecutive patients undergoing liver surgery were treated according to this protocol (ERAS group). They were compared in terms of real in-hospital costs with a patient series before ERAS implementation (pre-ERAS group). Mean costs per patient were compared with a bootstrap T test. A cost-minimization analysis was performed. Seventy-four ERAS patients were compared with 100 pre-ERAS patients. There were no significant pre- and intraoperative differences between the two groups, except for the laparoscopy number (n = 18 ERAS, n = 9 pre-ERAS, p = 0.010). Overall postoperative complications were observed in 36 (49 %) and 64 patients (64 %) in the ERAS and pre-ERAS groups, respectively (p = 0.046). The median length of stay was significantly shorter for the ERAS group (8 vs. 10 days, p = 0.006). The total mean costs per patient were €38,726 and €42,356 for ERAS and pre-ERAS (p = 0.467). The cost-minimization analysis showed a total mean cost reduction of €3080 per patient after ERAS implementation. ERAS implementation for liver surgery induced a non-significant decrease in cost compared to standard care. Significant decreased complication rate and hospital stay were observed in the ERAS group.

  1. Hepatic sinusoidal obstruction syndrome caused by herbal medicine: CT and MRI features

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Hua; Lou, Hai Yan [Dept. of Radiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou (China); Wang, Yi Xiang J. [Dept. of Radiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou (China); Xu, Xiao Jun; Zhang, Min Ming [Dept. of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou (China)

    2014-04-15

    To describe the CT and MRI features of hepatic sinusoidal obstruction syndrome (HSOS) caused by herbal medicine Gynura segetum. The CT and MRI features of 16 consecutive Gynura segetum induced HSOS cases (12 men, 4 women) were analyzed. Eight patients had CT; three patients had MRI, and the remaining five patients had both CT and MRI examinations. Based on their clinical presentations and outcomes, the patients were classified into three categories: mild, moderate, and severe. The severity of the disease was also evaluated radiologically based on the abnormal hepatic patchy enhancement in post-contrast CT or MRI images. Ascites, patchy liver enhancement, and main right hepatic vein narrowing or occlusion were present in all 16 cases. Hepatomegaly and gallbladder wall thickening were present in 14 cases (87.5%, 14/16). Periportal high intensity on T2-weighted images was present in 6 cases (75%, 6/8). Normal liver parenchymal enhancement surrounding the main hepatic vein forming a clover-like sign was observed in 4 cases (25%, 4/16). The extent of patchy liver enhancement was statistically associated with clinical severity classification (kappa = 0.565). Ascites, patchy liver enhancement, and the main hepatic veins narrowing were the most frequent signs of herbal medicine induced HSOS. The grade of abnormal patchy liver enhancement was associated with the clinical severity.

  2. Hepatic sinusoidal obstruction syndrome caused by herbal medicine: CT and MRI features

    International Nuclear Information System (INIS)

    Zhou, Hua; Lou, Hai Yan; Wang, Yi Xiang J.; Xu, Xiao Jun; Zhang, Min Ming

    2014-01-01

    To describe the CT and MRI features of hepatic sinusoidal obstruction syndrome (HSOS) caused by herbal medicine Gynura segetum. The CT and MRI features of 16 consecutive Gynura segetum induced HSOS cases (12 men, 4 women) were analyzed. Eight patients had CT; three patients had MRI, and the remaining five patients had both CT and MRI examinations. Based on their clinical presentations and outcomes, the patients were classified into three categories: mild, moderate, and severe. The severity of the disease was also evaluated radiologically based on the abnormal hepatic patchy enhancement in post-contrast CT or MRI images. Ascites, patchy liver enhancement, and main right hepatic vein narrowing or occlusion were present in all 16 cases. Hepatomegaly and gallbladder wall thickening were present in 14 cases (87.5%, 14/16). Periportal high intensity on T2-weighted images was present in 6 cases (75%, 6/8). Normal liver parenchymal enhancement surrounding the main hepatic vein forming a clover-like sign was observed in 4 cases (25%, 4/16). The extent of patchy liver enhancement was statistically associated with clinical severity classification (kappa = 0.565). Ascites, patchy liver enhancement, and the main hepatic veins narrowing were the most frequent signs of herbal medicine induced HSOS. The grade of abnormal patchy liver enhancement was associated with the clinical severity.

  3. Enhanced cooperation between IAEA and Republic of Korea on safeguards implementation at light water reactors

    International Nuclear Information System (INIS)

    Park, Wan-Sou; Kim, Byung-Koo; Yim, Seuk-Soon

    2001-01-01

    Full text: In Korea, national inspection has been initiated from the second half of 1997. From 1999, national inspection has been carried out for all nuclear facilities in Korea. In 2000, national inspections were performed successfully in 32 nuclear facilities including 12 PWRs, 4 CANDU reactors, 10 research facilities, 4 fuel fabrication plants and others. As the national inspection system settled down, both the IAEA and Korea were looking for possible ways of cooperation for mutual benefit. It was expected that considerable saving on inspection resources as well as more effective safeguards implementation could be achieved, if more enhanced cooperation work was realized. In 1999, the IAEA and Korea agreed to establish a working group for the enhanced cooperation between both sides. A working group, composed of experts from the IAEA and ROK, reviewed several options for enhanced cooperation on LWRs in Korea and suggested a measure for implementing the current safeguards approach for LWRs with remote monitoring. The basic concepts of the Enhanced Cooperation Scheme are: 1. The SSAC shall carry out all scheduled inspections for each facility for each year, while the Agency shall carry out the annual PIV and post-PIV, and a random selection of the remaining inspections; 2, The remote monitoring (RM) data necessary for technical and safeguards review shall be shared between the Agency and SSAC; 3. The IAEA shall bear the costs of purchasing RM equipment and communication operating costs from the central hub station in Korea to Vienna; the ROK will bear the costs of installing all RM equipment and communication operating costs from each LWR to the central hub station in Korea. Typically, around 8-9 inspections are performed for one LWR per annum under current safeguards approach; 1 pre-PIV, 1 PIV, 1 post-PIV, 3-4 interim inspections, fresh fuel receipts and simultaneous inspection. RM design includes 2 digital cameras (equipment hatch and spent fuel pond), VACOSS

  4. Effectiveness-implementation hybrid designs: combining elements of clinical effectiveness and implementation research to enhance public health impact.

    Science.gov (United States)

    Curran, Geoffrey M; Bauer, Mark; Mittman, Brian; Pyne, Jeffrey M; Stetler, Cheryl

    2012-03-01

    This study proposes methods for blending design components of clinical effectiveness and implementation research. Such blending can provide benefits over pursuing these lines of research independently; for example, more rapid translational gains, more effective implementation strategies, and more useful information for decision makers. This study proposes a "hybrid effectiveness-implementation" typology, describes a rationale for their use, outlines the design decisions that must be faced, and provides several real-world examples. An effectiveness-implementation hybrid design is one that takes a dual focus a priori in assessing clinical effectiveness and implementation. We propose 3 hybrid types: (1) testing effects of a clinical intervention on relevant outcomes while observing and gathering information on implementation; (2) dual testing of clinical and implementation interventions/strategies; and (3) testing of an implementation strategy while observing and gathering information on the clinical intervention's impact on relevant outcomes. The hybrid typology proposed herein must be considered a construct still in evolution. Although traditional clinical effectiveness and implementation trials are likely to remain the most common approach to moving a clinical intervention through from efficacy research to public health impact, judicious use of the proposed hybrid designs could speed the translation of research findings into routine practice.

  5. Enhanced Recovery Implementation in Major Gynecologic Surgeries: Effect of Care Standardization.

    Science.gov (United States)

    Modesitt, Susan C; Sarosiek, Bethany M; Trowbridge, Elisa R; Redick, Dana L; Shah, Puja M; Thiele, Robert H; Tiouririne, Mohamed; Hedrick, Traci L

    2016-09-01

    To examine implementing an enhanced recovery after surgery (ERAS) protocol for women undergoing major gynecologic surgery at an academic institution and compare surgical outcomes before and after implementation. Two ERAS protocols were developed: a full pathway using regional anesthesia for open procedures and a light pathway without regional anesthesia for vaginal and minimally invasive procedures. Enhanced recovery after surgery pathways included extensive preoperative counseling, carbohydrate loading and oral fluids before surgery, multimodal analgesia with avoidance of intravenous opioids, intraoperative goal-directed fluid resuscitation, and immediate postoperative feeding and ambulation. A before-and-after study design was used to compare clinical outcomes, costs, and patient satisfaction. Complications and risk-adjusted length of stay were drawn from the American College of Surgeons' National Surgical Quality Improvement Program database. On the ERAS full protocol, 136 patients were compared with 211 historical controls and the median length of stay was reduced (2.0 compared with 3.0 days; P=.007) despite an increase in National Surgical Quality Improvement Program-predicted length of stay (2.5 compared with 2.0 days; P=.009). Reductions were seen in median intraoperative morphine equivalents (0.3 compared with 12.7 mg; Pcontrols and demonstrated decreased intraoperative and postoperative morphine equivalents (0.0 compared with 13.0 mg; Pcontrol, nurses keeping patients informed, and staff teamwork; 30-day total hospital costs were significantly decreased in both ERAS groups. Implementation of ERAS protocols in gynecologic surgery was associated with a substantial decrease in intravenous fluids and morphine administration coupled with reduction in length of stay for open procedures combined with improved patient satisfaction and decreased hospital costs.

  6. On the practice of the clinical implementation of enhanced dynamic wedges

    International Nuclear Information System (INIS)

    Koken, Phil W.; Heukelom, Stan; Cuijpers, Johan P.

    2003-01-01

    Practical aspects of the clinical implementation of enhanced dynamic wedges (EDW) replacing manual wedges are presented and discussed extensively. A comparison between measured and calculated data is also presented. Relative dose distributions and wedge factors were calculated with a commercially available treatment planning system and measured in a water-phantom and with an ionization chamber. Wedge factor calculations and measurements were also compared with an independent method of wedge factor calculations available from the literature. Aspects of the clinical implementation, such as safety and quality assurance, were evaluated. Measurements and calculations agreed very well and were slightly better than results of previous studies. Profiles and percentage depth doses (PDDs) agreed within 1% to 1.5% and within 0.5%, respectively. Measured and calculated wedge factors ratios agreed within 0.5% to 1%. Calculated and measured EDW dose distributions showed excellent agreement, both relative and absolute. However, for safe and practical use, specific aspects need to be taken into consideration. Once the treatment planning system is commissioned properly, the clinical implementation of EDW is rather straightforward

  7. Sinusoidal potential cycling operation of a direct ethanol fuel cell to improving carbon dioxide yields

    Science.gov (United States)

    Majidi, Pasha; Pickup, Peter G.

    2014-12-01

    A direct ethanol fuel cell has been operated under sinusoidal (AC) potential cycling conditions in order to increase the yield of carbon dioxide and thereby increase cell efficiency relative to operation at a fixed potential. At 80 °C, faradaic yields of CO2 as high as 25% have been achieved with a PtRu anode catalyst, while the maximum CO2 production at constant potential was 13%. The increased yields under cycling conditions have been attributed to periodic oxidative stripping of adsorbed CO. These results will be important in the optimization of operating conditions for direct ethanol fuel cells, where the benefits of potential cycling are projected to increase as catalysts that produce CO2 more efficiently are implemented.

  8. Propiedades de transporte de una superred de grafeno tipo sinusoidal

    Directory of Open Access Journals (Sweden)

    J. A. Briones-Torres

    2015-01-01

    Full Text Available En este trabajo usamos el método de la matriz de transferencia para estudiar el tunelamiento de los electrones de Dirac a través de superredes en grafeno. Consideramos una superred con potencial sinusoidal o polaridad invertida, para ello consideramos dos maneras de crearla, una por medio de sustratos mixtos junto con la aplicación de un campo perpendicular sobre el sustrato de Óxido de Silicio (SiO2, la otra por medio de potenciales alternados aplicados perpendicularmente sobre la sábana de grafeno. Calculamos las propiedades de transmisión, transporte y estructura electrónica, variando diferentes parámetros como ángulo de incidencia, anchos de pozos y barreras y diferente número de barreras. Se encontró (1 el importante papel que juega el efecto Klein en tales estructuras, (2 las propiedades de transmisión y transporte presentan cierta simetría respecto del origen de la energía, y (3 el carácter sinusoidal del sistema trae consigo una baja en el nivel de energía de las subbandas en el espectro de estados acotados, además las degenera y origina que la apertura-cierre de las minibandas sea en el mismo nivel de energía.

  9. Observation of Sinusoidal Voltage Behaviour in Silver Doped YBCO

    Science.gov (United States)

    Altinkok, Atilgan; Olutas, Murat; Kilic, Kivilcim; Kilic, Atilla

    The influence of bi-directional square wave (BSW) current was investigated on the evolution of the V - t curves at different periods (P) , temperatures and external magnetic fields. It was observed that slow transport relaxation measurements result in regular sinusoidal voltage oscillations which were discussed mainly in terms of the dynamic competition between pinning and depinning.The symmetry in the voltage oscillations was attributed to the elastic coupling between the flux lines and the pinning centers along grain boundaries and partly inside the grains. This case was also correlated to the equality between flux entry and exit along the YBCO/Ag sample during regular oscillations. It was shown that the voltage oscillations can be described well by an empirical expression V (t) sin(wt + φ) . We found that the phase angle φgenerally takes different values for the repetitive oscillations. Fast Fourier Transform analysis of the V - t oscillations showed that the oscillation period is comparable to that (PI) of the BSW current. This finding suggests a physical mechanism associated with charge density waves (CDWs), and, indeed, the weakly pinned flux line system in YBCO/Ag resembles the general behavior of CDWs. At certain values of PI, amplitude of BSW current, H and T, the YBCO/Ag sample behaves like a double-integrator, since it converts the BSW current to sinusoidal voltage oscillations in time.

  10. Removal of Stationary Sinusoidal Noise from Random Vibration Signals.

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Brian; Cap, Jerome S.

    2018-02-01

    In random vibration environments, sinusoidal line noise may appear in the vibration signal and can affect analysis of the resulting data. We studied two methods which remove stationary sine tones from random noise: a matrix inversion algorithm and a chirp-z transform algorithm. In addition, we developed new methods to determine the frequency of the tonal noise. The results show that both of the removal methods can eliminate sine tones in prefabricated random vibration data when the sine-to-random ratio is at least 0.25. For smaller ratios down to 0.02 only the matrix inversion technique can remove the tones, but the metrics to evaluate its effectiveness also degrade. We also found that using fast Fourier transforms best identified the tonal noise, and determined that band-pass-filtering the signals prior to the process improved sine removal. When applied to actual vibration test data, the methods were not as effective at removing harmonic tones, which we believe to be a result of mixed-phase sinusoidal noise.

  11. Mapping surface properties of sinusoidal roughness standards by TPM

    International Nuclear Information System (INIS)

    Liu, X; Rubert, P

    2005-01-01

    We report our investigation on the surface properties of sinusoidal roughness standards made from pure electroformed nickel. Two specimens having a sinusoidal profile with nominal R a of 0.36 μm and a peak spacing of 25 μm are chosen for this investigation. One specimen is further treated with a hard protective coating of nickel-boron. The surface topography, friction, hardness and Young's modulus of the specimens were measured by a novel instrument, the multi-function Tribological Probe Microscope (TPM). The results show that hardness of these two specimens is 14.1 GPa for uncoated specimen and 25.7 GPa for the coated one, while the Young's modulus is 188 GPa and 225 GPa, respectively. The ramping force was set to 3mN for both the specimens and the effect of the tip penetration was investigated by comparing the topography measurements before and after hardness mapping. It has been found out that there is no significant change in the averaged profiles over the scanned area, which indicates the topography distortion seen in the multi-function mapping, is recoverable. Cross correlation between topography and its corresponding hardness/Young's modulus has been carried out and the result will be discussed in the paper

  12. Hydraulic testing in granite using the sinusoidal variation of pressure

    International Nuclear Information System (INIS)

    Black, J.H.; Holmes, D.C.; Noy, D.J.

    1982-09-01

    Access to two boreholes at the Carwynnen test site in Cornwall enabled the trial of a number of innovative approaches to the hydrogeology of fractured crystalline rock. These methods ranged from the use of seisviewer data to measure the orientation of fractures to the use of the sinusoidal pressure technique to measure directional hydraulic diffusivity. The testing began with a short programme of site investigation consisting of borehole caliper and seisviewer logging followed by some single borehole hydraulic tests. The single borehole hydraulic testing was designed to assess whether the available boreholes and adjacent rock were suitable for testing using the sinusoidal method. The main testing methods were slug and pulse tests and were analysed using the fissured porous medium analysis proposed in Barker and Black (1983). Derived hydraulic conductivity (K) ranged from 2 x 10 -12 m/sec to 5 x 10 -7 m/sec with one near-surface zone of high K being perceived in both boreholes. The results were of the form which is typical of fractured rock and indicated a combination of high fracture frequency and permeable granite matrix. The results are described and discussed. (author)

  13. Implementing an innovative intervention to increase research capacity for enhancing early psychosis care in Indonesia.

    Science.gov (United States)

    Renwick, L; Irmansyah; Keliat, B A; Lovell, K; Yung, A

    2017-11-01

    WHAT IS KNOWN ON THE TOPIC?: In low- and middle-income settings (LMICs) such as Indonesia, the burden from psychotic illness is significant due to large gaps in treatment provision Mental health workers and community nurses are a growing workforce requiring new evidence to support practice and enhanced roles and advanced competencies among UK mental health nurses also requires greater research capacity Research capacity building projects can strengthen research institutions, enhance trial capacity, improve quality standards and improve attitudes towards the importance of health research. WHAT THIS PAPER ADDS?: Delivering innovative, cross-cultural workshops to enhance research capacity to multidisciplinary, early career researchers in Indonesia and the UK are rated highly by attendees Supporting people in this way helps them to gain competitive grant funding to complete their own research which can improve the health of the population To our knowledge, there are no other studies reporting the attainment of grant income as a successful outcome of international research partnerships for mental health nursing so our finding is novel. WHAT ARE THE IMPLICATIONS FOR PRACTICE?: This method could be implemented to improve networking and collaboration between UK academics and early career researchers in other lower- and middle-income settings This strategy can also strengthen existing partnerships among early career researchers in the UK to meet the demands for greater research mentorship and leadership among mental health nurses and enhance nurses capabilities to contribute to evidence for practice. Aim To strengthen research capacity for nurses and early career researchers in Indonesia and the UK to develop a local evidence base in Indonesia to inform policy and improve the nation's health. These strategies can strengthen research institutions, enhance trial capacity, improve quality standards and improve attitudes towards the importance of health research. Methods Four

  14. Design of Helical Capacitance Sensor for Holdup Measurement in Two-Phase Stratified Flow: A Sinusoidal Function Approach

    Science.gov (United States)

    Lim, Lam Ghai; Pao, William K. S.; Hamid, Nor Hisham; Tang, Tong Boon

    2016-01-01

    A 360° twisted helical capacitance sensor was developed for holdup measurement in horizontal two-phase stratified flow. Instead of suppressing nonlinear response, the sensor was optimized in such a way that a ‘sine-like’ function was displayed on top of the linear function. This concept of design had been implemented and verified in both software and hardware. A good agreement was achieved between the finite element model of proposed design and the approximation model (pure sinusoidal function), with a maximum difference of ±1.2%. In addition, the design parameters of the sensor were analysed and investigated. It was found that the error in symmetry of the sinusoidal function could be minimized by adjusting the pitch of helix. The experiments of air-water and oil-water stratified flows were carried out and validated the sinusoidal relationship with a maximum difference of ±1.2% and ±1.3% for the range of water holdup from 0.15 to 0.85. The proposed design concept therefore may pose a promising alternative for the optimization of capacitance sensor design. PMID:27384567

  15. Design of Helical Capacitance Sensor for Holdup Measurement in Two-Phase Stratified Flow: A Sinusoidal Function Approach

    Directory of Open Access Journals (Sweden)

    Lam Ghai Lim

    2016-07-01

    Full Text Available A 360° twisted helical capacitance sensor was developed for holdup measurement in horizontal two-phase stratified flow. Instead of suppressing nonlinear response, the sensor was optimized in such a way that a ‘sine-like’ function was displayed on top of the linear function. This concept of design had been implemented and verified in both software and hardware. A good agreement was achieved between the finite element model of proposed design and the approximation model (pure sinusoidal function, with a maximum difference of ±1.2%. In addition, the design parameters of the sensor were analysed and investigated. It was found that the error in symmetry of the sinusoidal function could be minimized by adjusting the pitch of helix. The experiments of air-water and oil-water stratified flows were carried out and validated the sinusoidal relationship with a maximum difference of ±1.2% and ±1.3% for the range of water holdup from 0.15 to 0.85. The proposed design concept therefore may pose a promising alternative for the optimization of capacitance sensor design.

  16. Design of Helical Capacitance Sensor for Holdup Measurement in Two-Phase Stratified Flow: A Sinusoidal Function Approach.

    Science.gov (United States)

    Lim, Lam Ghai; Pao, William K S; Hamid, Nor Hisham; Tang, Tong Boon

    2016-07-04

    A 360° twisted helical capacitance sensor was developed for holdup measurement in horizontal two-phase stratified flow. Instead of suppressing nonlinear response, the sensor was optimized in such a way that a 'sine-like' function was displayed on top of the linear function. This concept of design had been implemented and verified in both software and hardware. A good agreement was achieved between the finite element model of proposed design and the approximation model (pure sinusoidal function), with a maximum difference of ±1.2%. In addition, the design parameters of the sensor were analysed and investigated. It was found that the error in symmetry of the sinusoidal function could be minimized by adjusting the pitch of helix. The experiments of air-water and oil-water stratified flows were carried out and validated the sinusoidal relationship with a maximum difference of ±1.2% and ±1.3% for the range of water holdup from 0.15 to 0.85. The proposed design concept therefore may pose a promising alternative for the optimization of capacitance sensor design.

  17. Implementation of Continuous Video-Electroencephalography at a Community Hospital Enhances Care and Reduces Costs.

    Science.gov (United States)

    Kolls, Brad J; Mace, Brian E; Dombrowski, Keith E

    2017-10-24

    Despite data indicating the importance of continuous video-electroencephalography (cvEEG) monitoring, adoption has been slow outside major academic centers. Barriers to adoption include the need for technologists, equipment, and cvEEG readers. Advancements in lower-cost lead placement templates and commercial systems with remote review may reduce barriers to allow community centers to implement cvEEG. Here, we report our experience, lessons learned, and financial impact of implementing a community hospital cvEEG-monitoring program. We implemented an adult cvEEG service at Duke Regional Hospital (DRH), a community hospital affiliate, in June of 2012. Lead placement templates were used in the implementation to reduce the impact on technologists by using other bedside providers for EEG initiation. Utilization of the service, study quality, and patient outcomes were tracked over a 3-year period following initiation of service. Service was implemented at essentially no cost. Utilization varied from a number of factors: intensive care unit (ICU) attending awareness, limited willingness of bedside providers to perform lead placement, and variation in practice of the consulting neurologists. A total of 92 studies were performed on 88 patients in the first 3 years of the program, 24 in year one, 27 in year two, and 38 in year three, showing progressive adoption. Seizures were seen in 25 patients (27%), 19 were in status, of which 18 were successfully treated. Transfers to the main hospital, Duke University Medical Center, were prevented for 53 patients, producing an estimated cost savings of $145,750. The retained patients produced a direct contribution margin of about $75,000, and the margin was just over $100,000 for the entire monitored cohort. ICU cvEEG service is feasible and practical to implement at the community hospital level. Service was initiated at little to no cost and clearly enhanced care, increased breadth of care, increased ICU census, and reduced

  18. Sinusoidal voltage protocols for rapid characterisation of ion channel kinetics.

    Science.gov (United States)

    Beattie, Kylie A; Hill, Adam P; Bardenet, Rémi; Cui, Yi; Vandenberg, Jamie I; Gavaghan, David J; de Boer, Teun P; Mirams, Gary R

    2018-03-24

    Ion current kinetics are commonly represented by current-voltage relationships, time constant-voltage relationships and subsequently mathematical models fitted to these. These experiments take substantial time, which means they are rarely performed in the same cell. Rather than traditional square-wave voltage clamps, we fitted a model to the current evoked by a novel sum-of-sinusoids voltage clamp that was only 8 s long. Short protocols that can be performed multiple times within a single cell will offer many new opportunities to measure how ion current kinetics are affected by changing conditions. The new model predicts the current under traditional square-wave protocols well, with better predictions of underlying currents than literature models. The current under a novel physiologically relevant series of action potential clamps is predicted extremely well. The short sinusoidal protocols allow a model to be fully fitted to individual cells, allowing us to examine cell-cell variability in current kinetics for the first time. Understanding the roles of ion currents is crucial to predict the action of pharmaceuticals and mutations in different scenarios, and thereby to guide clinical interventions in the heart, brain and other electrophysiological systems. Our ability to predict how ion currents contribute to cellular electrophysiology is in turn critically dependent on our characterisation of ion channel kinetics - the voltage-dependent rates of transition between open, closed and inactivated channel states. We present a new method for rapidly exploring and characterising ion channel kinetics, applying it to the hERG potassium channel as an example, with the aim of generating a quantitatively predictive representation of the ion current. We fitted a mathematical model to currents evoked by a novel 8 second sinusoidal voltage clamp in CHO cells overexpressing hERG1a. The model was then used to predict over 5 minutes of recordings in the same cell in response to

  19. Implementation of an Enhanced Measurement Control Program for handling nuclear safety samples at WSRC

    International Nuclear Information System (INIS)

    Boler-Melton, C.; Holland, M.K.

    1991-01-01

    In the separation and purification of nuclear material, nuclear criticality safety (NCS) is of primary concern. The primary nuclear criticality safety controls utilized by the Savannah River Site (SRS) Separations Facilities involve administrative and process equipment controls. Additional assurance of NCS is obtained by identifying key process hold points where sampling is used to independently verify the effectiveness of production control. Nuclear safety measurements of samples from these key process locations provide a high degree of assurance that processing conditions are within administrative and procedural nuclear safety controls. An enhanced procedure management system aimed at making improvements in the quality, safety, and conduct of operation was implemented for Nuclear Safety Sample (NSS) receipt, analysis, and reporting. All procedures with nuclear safety implications were reviewed for accuracy and adequate detail to perform the analytical measurements safely, efficiently, and with the utmost quality. Laboratory personnel worked in a ''Deliberate Operating'' mode (a systematic process requiring continuous expert oversight during all phases of training, testing, and implementation) to initiate the upgrades. Thus, the effort to revise and review nuclear safety sample procedures involved a team comprised of a supervisor, chemist, and two technicians for each procedure. Each NSS procedure was upgraded to a ''Use Every Time'' (UET) procedure with sign-off steps to ensure compliance with each step for every nuclear safety sample analyzed. The upgrade program met and exceeded both the long and short term customer needs by improving measurement reliability, providing objective evidence of rigid adherence to program principles and requirements, and enhancing the system for independent verification of representative sampling from designated NCS points

  20. Real-time implementations of acoustic signal enhancement techniques for aerial based surveillance and rescue applications

    Science.gov (United States)

    Ramos, Antonio L. L.; Shao, Zhili; Holthe, Aleksander; Sandli, Mathias F.

    2017-05-01

    The introduction of the System-on-Chip (SoC) technology has brought exciting new opportunities for the development of smart low cost embedded systems spanning a wide range of applications. Currently available SoC devices are capable of performing high speed digital signal processing tasks in software while featuring relatively low development costs and reduced time-to-market. Unmanned aerial vehicles (UAV) are an application example that has shown tremendous potential in an increasing number of scenarios, ranging from leisure to surveillance as well as in search and rescue missions. Video capturing from UAV platforms is a relatively straightforward task that requires almost no preprocessing. However, that does not apply to audio signals, especially in cases where the data is to be used to support real-time decision making. In fact, the enormous amount of acoustic interference from the surroundings, including the noise from the UAVs propellers, becomes a huge problem. This paper discusses a real-time implementation of the NLMS adaptive filtering algorithm applied to enhancing acoustic signals captured from UAV platforms. The model relies on a combination of acoustic sensors and a computational inexpensive algorithm running on a digital signal processor. Given its simplicity, this solution can be incorporated into the main processing system of an UAV using the SoC technology, and run concurrently with other required tasks, such as flight control and communications. Simulations and real-time DSP-based implementations have shown significant signal enhancement results by efficiently mitigating the interference from the noise generated by the UAVs propellers as well as from other external noise sources.

  1. Enhancing the Macedonian Health System through Implementation of the Public-Private Partnership Model

    Directory of Open Access Journals (Sweden)

    Dr.Sc. Iskra Belazelkoska Borizovska

    2017-06-01

    Full Text Available The research involves determination of the extent to which the public-private partnership model can contribute to the improvement and enhancement of the healthcare services in Macedonia. To achieve this purpose, the research embraces comprehension of the common advantages and disadvantages of this model, encompassed with a case study of the public-private partnership in the specialized-consultative health protection for the health activity-dialysis, together with other efforts to ensure high quality health protection. It also reflects the attitudes of the public authorities and private sector entities regarding the significance of the public-private partnership model, consideration of the advantages and disadvantages before entering public-private partnerships and the ways public-private partnerships affect the employees and employments. The study outlines planned and realised efforts to implement this model to ensure better and more efficient healthcare system. Generally, the results from the survey and the outlined case study present this model as good solution for many healthcare challenges, since public-private partnerships offer different services to the citizens that neither the public nor the private sector could separately achieve. The public-private partnership model leads to new employment opportunities according to the opinion of the public authorities, while the private sector entities consider that public-private partnerships increase the responsibility of the employees in such partnership in comparison to the public sector. The outlined case study is an example of successful public-private partnership model in the field of healthcare and can serve as motivation for further implementation of this model to ensure better, enhanced and modern health system.

  2. Design and Implementation of Equipment for Enhanced Safeguards of a Plutonium Storage in a Reprocessing Plant

    International Nuclear Information System (INIS)

    Richir, P.; Dechamp, L.; Buchet, P.; Dransart, P.; Dzbikowicz, Z.; Peerani, P.; ); Pierssens, L.; Persson, L.; Ancius, D.; Synetos, S.; ); Edmonds, N.; Homer, A.; Benn, K.-A.; Polkey, A.

    2015-01-01

    The Nuclear Security unit (NUSEC) of the Institute for Transuranium Elements (ITU, JRC) was entrusted by DG ENER to design and implement equipment in order to achieve enhanced safeguards of a plutonium dioxide storage located on the MAGNOX reprocessing plant in Sellafield (UK). Enhanced safeguards must lead to a win-win situation for all parties involved. In this case the DG ENER inspectorate will save inspection time, manpower and future financial resources and the operator will have the right to access its storage without the need for inspector presence. To reach this goal, while at the same time taking into account current budget constraints, NUSEC developed applications that use equipment commonly used in the safety and security fields but so far have not been used in safeguards. For instance, two laser scanners are used to detect entry/exit events into and out of the store and to provide the necessary information to an algorithm in order to categorize objects/people passing the scanners, e.g., a Fork Lift Truck, a trolley used to bring in PuO 2 containers, a system used for the dispatch of cans, people, etc. An RFID reader is used to identify equipment duly authorized to access the store. All PuO 2 containers arriving from the production line must be weighed, identified and measured using gamma and neutron detectors before they can be transferred to the store. For this purpose an Unattended Combined Measurement System (UCMS) was designed and manufactured by the JRC in order to do all verification activities using a single instrument. This paper describes the design features of the equipment and its implementation with the support of the Sellafield Ltd. in the framework of the MAGNOX store project. (author)

  3. Implementation and evaluation of critical thinking strategies to enhance critical thinking skills in Middle Eastern nurses.

    Science.gov (United States)

    Simpson, Elaine; Courtney, Mary

    2008-12-01

    The purpose of this study was to develop, implement and evaluate critical thinking strategies to enhance critical thinking skills in Middle Eastern nurses. Critical thinking strategies such as questioning, debate, role play and small group activity were developed and used in a professional development programme, which was trialled on a sample of Middle Eastern nurses (n = 20), to promote critical thinking skills, encourage problem solving, development of clinical judgment making and care prioritization in order to improve patient care and outcomes. Classroom learning was transformed from memorization to interaction and active participation. The intervention programme was successful in developing critical thinking skills in both the nurse educators and student nurses in this programme. This programme successfully integrated critical thinking strategies into a Middle Eastern nursing curriculum. Recommendations are as follows: (1) utilize evidence-based practice and stem questions to encourage the formulation of critical thinking questions; (2) support the needs of nurse educators for them to effectively implement teaching strategies to foster critical thinking skills; and (3) adopt creative approaches to (i) transform students into interactive participants and (ii) open students' minds and stimulate higher-level thinking and problem-solving abilities.

  4. Current and Voltage Mode Multiphase Sinusoidal Oscillators Using CBTAs

    Directory of Open Access Journals (Sweden)

    M. Sagbas

    2013-04-01

    Full Text Available Current-mode (CM and voltage-mode (VM multiphase sinusoidal oscillator (MSO structures using current backward transconductance amplifier (CBTA are proposed. The proposed oscillators can generate n current or voltage signals (n being even or odd equally spaced in phase. n+1 CBTAs, n grounded capacitors and a grounded resistor are used for nth-state oscillator. The oscillation frequency can be independently controlled through transconductance (gm of the CBTAs which are adjustable via their bias currents. The effects caused by the non-ideality of the CBTA on the oscillation frequency and condition have been analyzed. The performance of the proposed circuits is demonstrated on third-stage and fifth-stage MSOs by using PSPICE simulations based on the 0.25 µm TSMC level-7 CMOS technology parameters.

  5. Phonological awareness and sinusoidal amplitude modulation in phonological dislexia.

    Science.gov (United States)

    Peñaloza-López, Yolanda; Herrera-Rangel, Aline; Pérez-Ruiz, Santiago J; Poblano, Adrián

    2016-04-01

    Dyslexia is the difficulty of children in learning to read and write as results of neurological deficiencies. The objective was to test the Phonological awareness (PA) and Sinusoidal amplitude modulation (SAM) threshold in children with Phonological dyslexia (PD). We performed a case-control, analytic, cross sectional study. We studied 14 children with PD and 14 control children from 7 to 11 years of age, by means of PA measurement and by SAM test. The mean age of dyslexic children was 8.39 years and in the control group was 8.15. Children with PD exhibited inadequate skills in PA, and SAM. We found significant correlations between PA and SAM at 4 Hertz frequency, and calculated regression equations that predicts between one-fourth and one-third of variance of measurements. Alterations in PA and SAM found can help to explain basis of deficient language processing exhibited by children with PD.

  6. New Realizations of Single OTRA-Based Sinusoidal Oscillators

    Directory of Open Access Journals (Sweden)

    Hung-Chun Chien

    2014-01-01

    Full Text Available This study proposes three new sinusoidal oscillators based on an operational transresistance amplifier (OTRA. Each of the proposed oscillator circuits consists of one OTRA combined with a few passive components. The first circuit is an OTRA-based minimum RC oscillator. The second circuit is capable of providing independent control on the condition of oscillation without affecting the oscillation frequency. The third circuit exhibits independent control of oscillation frequency through a capacitor. This study first introduces the OTRA and the related formulations of the proposed oscillator circuits, and then discusses the nonideal effects, sensitivity analyses, and frequency stability of the presented circuits. The proposed oscillators exhibit low sensitivities and good frequency stability. Because the presented circuits feature low impedance output, they can be connected directly to the next stage without cascading additional voltage buffers. HSPICE simulations and experimental results confirm the feasibility of the new oscillator circuits.

  7. One-dimensional plasma photonic crystals with sinusoidal densities

    International Nuclear Information System (INIS)

    Qi, L.; Shang, L.; Zhang, S.

    2014-01-01

    Properties of electromagnetic waves with normal and oblique incidence have been studied for one-dimensional plasma layers with sinusoidal densities. Wave transmittance as a function of wave frequency exhibits photonic band gaps characteristic of photonic crystals. For periodic structures, increasing collision frequency is demonstrated to lead to greater absorption, increasing the modulation factor enlarges the gap width, and increasing incidence angle can change the gap locations of the two polarizations. If a defect layer is introduced by inserting a new plasma layer in the center, a defect mode may appear within the gap. Periodic number, collision frequency, and modulation factor can affect magnitude of the defect mode. The incidence angle enables the frequency to be tuned. Defect layer thickness affects both frequency and number of defect modes. These results may provide theoretical guidance in designing tunable narrow-band filters

  8. Response of resonant gravitational wave detectors to damped sinusoid signals

    International Nuclear Information System (INIS)

    Pai, A; Celsi, C; Pallottino, G V; D'Antonio, S; Astone, P

    2007-01-01

    Till date, the search for burst signals with resonant gravitational wave (GW) detectors has been done using the δ-function approximation for the signal, which was reasonable due to the very small bandwidth of these detectors. However, now with increased bandwidth (of the order of 10 or more Hz) and with the possibility of comparing results with interferometric GW detectors (broad-band), it is very important to exploit the resonant detectors' capability to detect also signals with specific wave shapes. As a first step, we present a study of the response of resonant GW detectors to damped sinusoids with given frequency and decay time and report on the development of a filter matched to these signals. This study is a preliminary step towards the comprehension of the detector response and of the filtering for signals such as the excitation of stellar quasi-normal modes

  9. Plasma characteristics in non-sinusoidally excited CCP discharges

    Science.gov (United States)

    Lafleur, Trevor; Booth, Jean-Paul

    2012-10-01

    Using particle-in-cell (PIC) simulations we perform a characterization of the plasma response to positive pulse-type voltage excitations (with a repetition frequency of 13.56 MHz) in a geometrically symmetric CCP reactor (with a gap length of 2 cm) operated with argon (for pressures between 20-500 mTorr). Use of these non-sinusoidal waveforms generates an electrical asymmetry effect in the system, which necessitates the formation of a DC bias. This DC bias, together with the shape of the voltage waveforms used, produces a number of new phenomena that are not present in typical sinusoidal discharges: (1) the plasma density and ion flux can be increased as the pulse width is reduced, (2) a significant asymmetry in the ion fluxes to the powered and grounded electrodes develops as the pressure increases, (3) the average ion energy striking the grounded electrode remains low and approximately constant as the pulse width decreases, and (4) the sheath at the grounded electrode never fully collapses; electrons are no longer lost in sharp pulses, but escape essentially throughout the rf cycle. Effects (1) and (3) above offer the possibility for a new form of control in these types of discharges, where the ion flux can be increased while the ion energy on the grounded electrode can be kept small and essentially constant. This effect has recently been exploited to control the crystallinity of silicon thin films [1], where the low ion bombarding energy was found to improve the quality of films grown. [4pt] [1] Johnson E V, Pouliquen S, Delattre P A, and Booth J P, J. Non-Cryst. Solids 2012, in press.

  10. Nematic liquid crystals on sinusoidal channels: the zigzag instability.

    Science.gov (United States)

    Silvestre, Nuno M; Romero-Enrique, Jose M; Telo da Gama, Margarida M

    2017-01-11

    Substrates which are chemically or topographically patterned induce a variety of liquid crystal textures. The response of the liquid crystal to competing surface orientations, typical of patterned substrates, is determined by the anisotropy of the elastic constants and the interplay of the relevant lengths scales, such as the correlation length and the surface geometrical parameters. Transitions between different textures, usually with different symmetries, may occur under a wide range of conditions. We use the Landau-de Gennes free energy to investigate the texture of nematics in sinusoidal channels with parallel anchoring bounded by nematic-air interfaces that favour perpendicular (hometropic) anchoring. In micron size channels 5CB was observed to exhibit a non-trivial texture characterized by a disclination line, within the channel, which is broken into a zigzag pattern. Our calculations reveal that when the elastic anisotropy of the nematic does not favour twist distortions the defect is a straight disclination line that runs along the channel, which breaks into a zigzag pattern with a characteristic period, when the twist elastic constant becomes sufficiently small when compared to the splay and bend constants. The transition occurs through a twist instability that drives the defect line to rotate from its original position. The interplay between the energetically favourable twist distortions that induce the defect rotation and the liquid crystal anchoring at the surfaces leads to the zigzag pattern. We investigate in detail the dependence of the periodicity of the zigzag pattern on the geometrical parameters of the sinusoidal channels, which in line with the experimental results is found to be non-linear.

  11. Representative Sinusoids for Hepatic Four-Scale Pharmacokinetics Simulations.

    Directory of Open Access Journals (Sweden)

    Lars Ole Schwen

    Full Text Available The mammalian liver plays a key role for metabolism and detoxification of xenobiotics in the body. The corresponding biochemical processes are typically subject to spatial variations at different length scales. Zonal enzyme expression along sinusoids leads to zonated metabolization already in the healthy state. Pathological states of the liver may involve liver cells affected in a zonated manner or heterogeneously across the whole organ. This spatial heterogeneity, however, cannot be described by most computational models which usually consider the liver as a homogeneous, well-stirred organ. The goal of this article is to present a methodology to extend whole-body pharmacokinetics models by a detailed liver model, combining different modeling approaches from the literature. This approach results in an integrated four-scale model, from single cells via sinusoids and the organ to the whole organism, capable of mechanistically representing metabolization inhomogeneity in livers at different spatial scales. Moreover, the model shows circulatory mixing effects due to a delayed recirculation through the surrounding organism. To show that this approach is generally applicable for different physiological processes, we show three applications as proofs of concept, covering a range of species, compounds, and diseased states: clearance of midazolam in steatotic human livers, clearance of caffeine in mouse livers regenerating from necrosis, and a parameter study on the impact of different cell entities on insulin uptake in mouse livers. The examples illustrate how variations only discernible at the local scale influence substance distribution in the plasma at the whole-body level. In particular, our results show that simultaneously considering variations at all relevant spatial scales may be necessary to understand their impact on observations at the organism scale.

  12. Sinusoidal Obstruction Syndrome (Hepatic Veno-Occlusive Disease)

    Science.gov (United States)

    Fan, Cathy Q.; Crawford, James M.

    2014-01-01

    Hepatic sinusoidal obstruction syndrome (SOS) is an obliterative venulitis of the terminal hepatic venules, which in its more severe forms imparts a high risk of mortality. SOS, also known as veno-occlusive disease (VOD), occurs as a result of cytoreductive therapy prior to hematopoietic stem cell transplantation (HSCT), following oxaliplatin-containing adjuvant or neoadjuvant chemotherapy for colorectal carcinoma metastatic to the liver and treated by partial hepatectomy, in patients taking pyrrolizidine alkaloid-containing herbal remedies, and in other particular settings such as the autosomal recessive condition of veno-occlusive disease with immunodeficiency (VODI). A central pathogenic event is toxic destruction of hepatic sinusoidal endothelial cells (SEC), with sloughing and downstream occlusion of terminal hepatic venules. Contributing factors are SEC glutathione depletion, nitric oxide depletion, increased intrahepatic expression of matrix metalloproteinases and vascular endothelial growth factor (VEGF), and activation of clotting factors. The clinical presentation of SOS includes jaundice, development of right upper-quadrant pain and tender hepatomegaly, ascites, and unexplained weight gain. Owing to the potentially critical condition of these patients, transjugular biopsy may be the preferred route for liver biopsy to exclude other potential causes of liver dysfunction and to establish a diagnosis of SOS. Treatment includes rigorous fluid management so as to avoid excessive fluid overload while avoiding too rapid diuresis or pericentesis, potential use of pharmaceutics such as defibrotide, coagulolytic agents, or methylprednisolone, and liver transplantation. Proposed strategies for prevention and prophylaxis include reduced-intensity conditioning radiation for HSCT, treatment with ursodeoxycholic acid, and inclusion of bevacizumab with oxaliplatin-based chemotherapeutic regimes. While significant progress has been made in understanding the pathogenesis

  13. A methodology for enhancing implementation science proposals: comparison of face-to-face versus virtual workshops.

    Science.gov (United States)

    Marriott, Brigid R; Rodriguez, Allison L; Landes, Sara J; Lewis, Cara C; Comtois, Katherine A

    2016-05-06

    With the current funding climate and need for advancements in implementation science, there is a growing demand for grantsmanship workshops to increase the quality and rigor of proposals. A group-based implementation science-focused grantsmanship workshop, the Implementation Development Workshop (IDW), is one methodology to address this need. This manuscript provides an overview of the IDW structure, format, and findings regarding its utility. The IDW methodology allows researchers to vet projects in the proposal stage in a structured format with a facilitator and two types of expert participants: presenters and attendees. The presenter uses a one-page handout and verbal presentation to present their proposal and questions. The facilitator elicits feedback from attendees using a format designed to maximize the number of unique points made. After each IDW, participants completed an anonymous survey assessing perceptions of the IDW. Presenters completed a funding survey measuring grant submission and funding success. Qualitative interviews were conducted with a subset of participants who participated in both delivery formats. Mixed method analyses were performed to evaluate the effectiveness and acceptability of the IDW and compare the delivery formats. Of those who participated in an IDW (N = 72), 40 participated in face-to-face only, 16 in virtual only, and 16 in both formats. Thirty-eight (face-to-face n = 12, 35 % response rate; virtual n = 26, 66.7 % response rate) responded to the surveys and seven (15.3 % response rate), who had attended both formats, completed an interview. Of 36 total presenters, 17 (face-to-face n = 12, 42.9 % response rate; virtual n = 5, 62.9 % response rate) responded to the funding survey. Mixed method analyses indicated that the IDW was effective for collaboration and growth, effective for enhancing success in obtaining grants, and acceptable. A third (35.3 %) of presenters ultimately received funding for their proposal, and more than

  14. Spline-based high-accuracy piecewise-polynomial phase-to-sinusoid amplitude converters.

    Science.gov (United States)

    Petrinović, Davor; Brezović, Marko

    2011-04-01

    We propose a method for direct digital frequency synthesis (DDS) using a cubic spline piecewise-polynomial model for a phase-to-sinusoid amplitude converter (PSAC). This method offers maximum smoothness of the output signal. Closed-form expressions for the cubic polynomial coefficients are derived in the spectral domain and the performance analysis of the model is given in the time and frequency domains. We derive the closed-form performance bounds of such DDS using conventional metrics: rms and maximum absolute errors (MAE) and maximum spurious free dynamic range (SFDR) measured in the discrete time domain. The main advantages of the proposed PSAC are its simplicity, analytical tractability, and inherent numerical stability for high table resolutions. Detailed guidelines for a fixed-point implementation are given, based on the algebraic analysis of all quantization effects. The results are verified on 81 PSAC configurations with the output resolutions from 5 to 41 bits by using a bit-exact simulation. The VHDL implementation of a high-accuracy DDS based on the proposed PSAC with 28-bit input phase word and 32-bit output value achieves SFDR of its digital output signal between 180 and 207 dB, with a signal-to-noise ratio of 192 dB. Its implementation requires only one 18 kB block RAM and three 18-bit embedded multipliers in a typical field-programmable gate array (FPGA) device. © 2011 IEEE

  15. Potential of Russian Regions to Implement CO2-Enhanced Oil Recovery

    Directory of Open Access Journals (Sweden)

    Alexey Cherepovitsyn

    2018-06-01

    Full Text Available The paper assesses the techno-economic potential of Russia to implement carbon capture and storage technologies that imply the capture of anthropogenic CO2 and its injection into geologic reservoirs for long-term storage. The focus is on CO2 enhanced oil recovery projects that seem to be the most economically promising option of carbon capture and storage. The novelty of the work lies in the formulation of a potential assessment method of CO2 enhanced oil recovery, which allows for establishing a connection between energy production and oil extraction from the viewpoint of CO2 supply and demand. Using linear optimization, the most promising combinations of CO2 sources and sinks are identified and an economic evaluation of these projects is carried out. Based on this information, regions of Russia are ranked according to their prospects in regards to CO2 capture and enhanced oil recovery storage. The results indicate that Russia has a significant potential to utilize its power plants as CO2 sources for enhanced oil recovery projects. It has been estimated that 71 coal-fired power plants, and 185 of the gas-fired power plants of Russia annually produce 297.1 and 309.6 Mt of CO2 that can cover 553.4 Mt of the demand of 322 Russian oil fields. At the same time, the total CO2 storage capacity of the Russian fields is estimated at 7382.6 Mt, however, due to geological and technical factors, only 22.6% can be used for CO2-EOR projects. Of the 183 potential projects identified in the regional analysis phase, 99 were found to be cost-effective, with an average unit cost of € 19.07 per ton of CO2 and a payback period of 8.71 years. The most promising of the estimated regions is characterized by a well-developed energy industry, relatively low transportation costs, numerous large and medium-sized oil fields at the final stages of development, and favorable geological conditions that minimize the cost of injection. Geographically, they are located in the

  16. Qualitative Assessment of Smoke-Free Policy Implementation in Low-Income Housing: Enhancing Resident Compliance.

    Science.gov (United States)

    Anthony, Jodi; Goldman, Roberta; Rees, Vaughan W; Frounfelker, Rochelle L; Davine, Jessica; Keske, Robyn R; Brooks, Daniel R; Geller, Alan C

    2018-01-01

    As public housing agencies and other low-income housing providers adopt smoke-free policies, data are needed to inform implementation approaches that support compliance. Focused ethnography used including qualitative interviews with staff, focus groups with residents, and property observations. Four low-income housing properties in Massachusetts, 12 months postpolicy adoption. Individual interviews (n = 17) with property staff (managers, resident service coordinators, maintenance, security, and administrators) and focus groups with resident smokers (n = 28) and nonsmokers (n = 47). Informed by the social-ecological model: intrapersonal, interpersonal, organizational, and community factors relating to compliance were assessed. Utilized MAXQDA in a theory-driven immersion/crystallization analytic process with cycles of raw data examination and pattern identification until no new themes emerged. Self-reported secondhand smoke exposure (SHSe) was reduced but not eliminated. Challenges included relying on ambivalent maintenance staff and residents to report violations, staff serving as both enforcers and smoking cessation counsellors, and inability to enforce on nights and weekends. Erroneous knowledge of the policy, perception that SHSe is not harmful to neighbors, as well as believing that smokers were losing their autonomy and being unfairly singled out when other resident violations were being unaddressed, hindered policy acceptance among resident smokers. The greatest challenge to compliance was the lack of allowable outdoor smoking areas that may have reduced the burden of the policy on smokers. Smoke-free policy implementation to support compliance could be enhanced with information about SHSe for smokers and nonsmokers, cessation support from external community partners, discussion forums for maintenance staff, resident inclusion in decision-making, and framing the policy as part of a broader wellness initiative.

  17. DISPLAY OF PIXEL LOSS AND REPLICATION IN REPROJECTING RASTER DATA FROM THE SINUSOIDAL PROJECTION

    Science.gov (United States)

    Recent studies show the sinusoidal projection to be a superior planar projection for representing global raster datasets. This study uses the sinusoidal projection as a basis for evaluating pixel loss and replication in eight other planar map projections. The percent of pixels ...

  18. Outcomes of implementation of enhanced goal directed therapy in high-risk patients undergoing abdominal surgery

    Directory of Open Access Journals (Sweden)

    Lakshmi Kumar

    2015-01-01

    Full Text Available Background and Aims: Advanced monitoring targeting haemodynamic and oxygenation variables can improve outcomes of surgery in high-risk patients. We aimed to assess the impact of goal directed therapy (GDT targeting cardiac index (CI and oxygen extraction ratio (O 2 ER on outcomes of high-risk patients undergoing abdominal surgery. Methods: In a prospective randomised trial, forty patients (American Society of Anaesthesiologists II and III undergoing major abdominal surgeries were randomised into two groups. In-Group A mean arterial pressure ≥ 65 mmHg, central venous pressure ≥ 8-10 mmHg, urine output ≥ 0.5 mL/kg/h and central venous oxygen saturation ≥ 70% were targeted intra-operatively and 12 h postoperatively. In-Group-B (enhanced GDT, in addition to the monitoring in-Group-A, CI ≥ 2.5 L/min/m 2 and O 2 ER ≤ 27% were targeted. The end-points were lactate levels and base deficit during and after surgery. The secondary end points were length of Intensive Care Unit (ICU and hospital stay and postoperative complications. Wilcoxon Mann Whitney and Chi-square tests were used for statistical assessment. Results: Lactate levels postoperatively at 4 and 8 h were lower in-Group-B (P < 0.05. The mean base deficit at 3, 4, 5 and 6 h intra-operatively and postoperatively after 4, 8 and 12 h were lower in-Group-B (P < 0.05. There were no significant differences in ICU stay (2.10 ± 1.52 vs. 2.90 ± 2.51 days or hospital stay (10.85 + 4.39 vs. 13.35 + 6.77 days between Group A and B. Conclusions: Implementation of enhanced GDT targeting CI and OER was associated with improved tissue oxygenation.

  19. Qualitative evaluation of the implementation of the Interdisciplinary Management Tool: a reflective tool to enhance interdisciplinary teamwork using Structured, Facilitated Action Research for Implementation.

    Science.gov (United States)

    Nancarrow, Susan A; Smith, Tony; Ariss, Steven; Enderby, Pamela M

    2015-07-01

    Reflective practice is used increasingly to enhance team functioning and service effectiveness; however, there is little evidence of its use in interdisciplinary teams. This paper presents the qualitative evaluation of the Interdisciplinary Management Tool (IMT), an evidence-based change tool designed to enhance interdisciplinary teamwork through structured team reflection. The IMT incorporates three components: an evidence-based resource guide; a reflective implementation framework based on Structured, Facilitated Action Research for Implementation methodology; and formative and summative evaluation components. The IMT was implemented with intermediate care teams supported by independent facilitators in England. Each intervention lasted 6 months and was evaluated over a 12-month period. Data sources include interviews, a focus group with facilitators, questionnaires completed by team members and documentary feedback from structured team reports. Data were analysed qualitatively using the Framework approach. The IMT was implemented with 10 teams, including 253 staff from more than 10 different disciplines. Team challenges included lack of clear vision; communication issues; limited career progression opportunities; inefficient resource use; need for role clarity and service development. The IMT successfully engaged staff in the change process, and resulted in teams developing creative strategies to address the issues identified. Participants valued dedicated time to focus on the processes of team functioning; however, some were uncomfortable with a focus on teamwork at the expense of delivering direct patient care. The IMT is a relatively low-cost, structured, reflective way to enhance team function. It empowers individuals to understand and value their own, and others' roles and responsibilities within the team; identify barriers to effective teamwork, and develop and implement appropriate solutions to these. To be successful, teams need protected time to take

  20. Sinusoidal oscillators and waveform generators using modern electronic circuit building blocks

    CERN Document Server

    Senani, Raj; Singh, V K; Sharma, R K

    2016-01-01

    This book serves as a single-source reference to sinusoidal oscillators and waveform generators, using classical as well as a variety of modern electronic circuit building blocks. It provides a state-of-the-art review of a large variety of sinusoidal oscillators and waveform generators and includes a catalogue of over 600 configurations of oscillators and waveform generators, describing their relevant design details and salient performance features/limitations. The authors discuss a number of interesting, open research problems and include a comprehensive collection of over 1500 references on oscillators and non-sinusoidal waveform generators/relaxation oscillators. Offers readers a single-source reference to everything connected to sinusoidal oscillators and waveform generators, using classical as well as modern electronic circuit building blocks; Provides a state-of-the-art review of a large variety of sinusoidal oscillators and waveform generators; Includes a catalog of over 600 configurations of oscillato...

  1. Perception of the dynamic visual vertical during sinusoidal linear motion.

    Science.gov (United States)

    Pomante, A; Selen, L P J; Medendorp, W P

    2017-10-01

    The vestibular system provides information for spatial orientation. However, this information is ambiguous: because the otoliths sense the gravitoinertial force, they cannot distinguish gravitational and inertial components. As a consequence, prolonged linear acceleration of the head can be interpreted as tilt, referred to as the somatogravic effect. Previous modeling work suggests that the brain disambiguates the otolith signal according to the rules of Bayesian inference, combining noisy canal cues with the a priori assumption that prolonged linear accelerations are unlikely. Within this modeling framework the noise of the vestibular signals affects the dynamic characteristics of the tilt percept during linear whole-body motion. To test this prediction, we devised a novel paradigm to psychometrically characterize the dynamic visual vertical-as a proxy for the tilt percept-during passive sinusoidal linear motion along the interaural axis (0.33 Hz motion frequency, 1.75 m/s 2 peak acceleration, 80 cm displacement). While subjects ( n =10) kept fixation on a central body-fixed light, a line was briefly flashed (5 ms) at different phases of the motion, the orientation of which had to be judged relative to gravity. Consistent with the model's prediction, subjects showed a phase-dependent modulation of the dynamic visual vertical, with a subject-specific phase shift with respect to the imposed acceleration signal. The magnitude of this modulation was smaller than predicted, suggesting a contribution of nonvestibular signals to the dynamic visual vertical. Despite their dampening effect, our findings may point to a link between the noise components in the vestibular system and the characteristics of dynamic visual vertical. NEW & NOTEWORTHY A fundamental question in neuroscience is how the brain processes vestibular signals to infer the orientation of the body and objects in space. We show that, under sinusoidal linear motion, systematic error patterns appear in the

  2. Design and Implementation of NTU Wearable Exoskeleton as an Enhancement and Assistive Device

    Directory of Open Access Journals (Sweden)

    K. H. Low

    2006-01-01

    Full Text Available This article presents a wearable lower extremity exoskeleton (LEE developed to enhance the ability of a human’s walking while carrying heavy loads. The ultimate goal of the current research work is to design and control a power assist system that integrates a human’s intellect for feedback and sensory purposes. The exoskeleton system in this work consists of an inner exoskeleton and an outer exoskeleton. The inner exoskeleton measures the movements of the wearer and provides these measurements to the outer exoskeleton, which supports the whole exoskeleton system to walk following the wearer. A special footpad, which is designed and attached to the outer exoskeleton, can measure the zero moment point (ZMP of the human as well as that of the exoskeleton in time. Using the measured human ZMP as the reference, the exoskeleton’s ZMP is controlled by trunk compensation so that the exoskeleton can walk stably. A simulation platform has first been developed to examine the gait coordination through inner and outer exoskeletons. A commercially available software, xPC Target, together with other toolboxes from MATLAB, has then been used to provide a real-time operating system for controlling the exoskeleton. Real-time locomotion control of the exoskeleton is implemented in the developed environment. Finally, some experiments on different objects showed that the stable walking can be achieved in the real environment.

  3. Enhancing public project implementation in Botswana during the NDP 11 period

    Directory of Open Access Journals (Sweden)

    Emmanuel Botlhale

    2017-08-01

    Full Text Available Successful project implementation is critical in development planning. If there is poor project implementation, economic development will be stalled. Generally, public project implementation has a chequered history. This is particularly true in developing countries which are characterised by low levels of project management maturity. The objective of this article is to review public project implementation in Botswana and recommend improvements for the National Development Plan (NDP 11 period (2017/2018-2022/2023. The article used the survey strategy and adopted the descriptive approach. Data collection sources were mixed, that is, primary and secondary sources. It concluded that public projects are either poorly implemented (i.e. not implemented in accordance with the ‘Project Management Triple Constraint’ of cost, time and scope or not implemented at all. Given a constrained revenue envelope post 2008, there is a need for improved project implementation. Amongst others, this calls for professional public project implementation so that NDPs become a reality.

  4. Isothermal sinusoidal analysis of balanced compound Vuilleumier heat pumps

    International Nuclear Information System (INIS)

    Finkelstein, T.

    1992-01-01

    This paper reports on Vuilleumier heat pumps with balanced compounding which have been under investigation for about fifteen years but have not yet reached the stage of commercial utilization. Previously published analytical treatment based upon isothermal treatment of the variable-volume spaces resulted in closed form solution of considerable complexity of the coupled differential equations but applied only to free piston machines. In contrast, the procedure presented here is based on previously demonstrated sinusoidal excursions of the reciprocators. It is of the same order of accuracy, but much more simple and usable. It was found that there is only negligible difference between the results of the present and the previous approach. Additionally, the treatment presented here is applicable to kinematic machines, as well as to free piston machines. For the latter design, an equation for the natural frequency is also derived. Ideal proportions and practical expressions for the energy streams are derived. Gas forces are plotted versus displacement and it is shown that they are equivalent to a linear spring, which is of importance for the concept of a free-piston design

  5. Sinusoidal Wave Estimation Using Photogrammetry and Short Video Sequences

    Directory of Open Access Journals (Sweden)

    Ewelina Rupnik

    2015-12-01

    Full Text Available The objective of the work is to model the shape of the sinusoidal shape of regular water waves generated in a laboratory flume. The waves are traveling in time and render a smooth surface, with no white caps or foam. Two methods are proposed, treating the water as a diffuse and specular surface, respectively. In either case, the water is presumed to take the shape of a traveling sine wave, reducing the task of the 3D reconstruction to resolve the wave parameters. The first conceived method performs the modeling part purely in 3D space. Having triangulated the points in a separate phase via bundle adjustment, a sine wave is fitted into the data in a least squares manner. The second method presents a more complete approach for the entire calculation workflow beginning in the image space. The water is perceived as a specular surface, and the traveling specularities are the only observations visible to the  cameras, observations that are notably single image. The depth ambiguity is removed given additional constraints encoded within the law of reflection and the modeled parametric surface. The observation and constraint equations compose a single system of equations that is solved with the method of least squares adjustment. The devised approaches are validated against the data coming from a capacitive level sensor and on physical targets floating on the surface. The outcomes agree to a high degree.

  6. Defibrotide in Severe Sinusoidal Obstruction Syndrome: Medicine and Economic Issues.

    Science.gov (United States)

    Steelandt, Julie; Bocquet, François; Cordonnier, Anne-Laure; De Courtivron, Charlotte; Fusier, Isabelle; Paubel, Pascal

    2017-02-01

    In Europe, Defitelio (defibrotide) has a Market Authorization in curative treatment of severe sinusoidal obstruction syndrome (SOS) but not in prophylaxis (2013). In France, defibrotide has had a compassionate-use program since 2009. Today, the high cost of defibrotide remains a major hurdle for hospital budgets. Medicine and economic issues were evaluated for the 39 hospitals of the French Public Assistance-Hospitals of Paris (AP-HP). We analyzed literature reviews, consumption, and expenditures through AP-HP data in 2014 and patient profiles with defibrotide in the corresponding diagnostic-related groups (DRGs) and consulted a board of hematologists. Finally, 18 publications were selected. Between 2011 and 2014 consumption increased to €5.2M. In 2014, 80 patients receiving defibrotide were mainly ascribed to the DRG "hematopoietic stem cell transplantation" levels 3 or 4. The tariffs attributed to drugs (€3544 to 4084) cover a small part of treatment costs (€97,524 for an adult). French experts thus recommended a harmonization of indications in prophylaxis (off-label use), improvement of pretransplant care, and optimization of the number of vials used. The economic impact led experts to change their practices. They recommended the restriction of defibrotide use to SOS curative treatment and to high-risk situations in prophylaxis. Copyright © 2017 The American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.

  7. Sinusoidal visuomotor tracking: intermittent servo-control or coupled oscillations?

    Science.gov (United States)

    Russell, D M; Sternad, D

    2001-12-01

    In visuomotor tasks that involve accuracy demands, small directional changes in the trajectories have been taken as evidence of feedback-based error corrections. In the present study variability, or intermittency, in visuomanual tracking of sinusoidal targets was investigated. Two lines of analyses were pursued: First, the hypothesis that humans fundamentally act as intermittent servo-controllers was re-examined, probing the question of whether discontinuities in the movement trajectory directly imply intermittent control. Second, an alternative hypothesis was evaluated: that rhythmic tracking movements are generated by entrainment between the oscillations of the target and the actor, such that intermittency expresses the degree of stability. In 2 experiments, participants (N = 6 in each experiment) swung 1 of 2 different hand-held pendulums, tracking a rhythmic target that oscillated at different frequencies with a constant amplitude. In 1 line of analyses, the authors tested the intermittency hypothesis by using the typical kinematic error measures and spectral analysis. In a 2nd line, they examined relative phase and its variability, following analyses of rhythmic interlimb coordination. The results showed that visually guided corrective processes play a role, especially for slow movements. Intermittency, assessed as frequency and power components of the movement trajectory, was found to change as a function of both target frequency and the manipulandum's inertia. Support for entrainment was found in conditions in which task frequency was identical to or higher than the effector's eigenfrequency. The results suggest that it is the symmetry between task and effector that determines which behavioral regime is dominant.

  8. Academic Workload: The Silent Barrier to the Implementation of Technology-Enhanced Learning Strategies in Higher Education

    Science.gov (United States)

    Gregory, Mary Sarah-Jane; Lodge, Jason Michael

    2015-01-01

    The effect of technology-enhanced learning (TEL) strategies in higher education has arguably been transformative despite the not-insignificant barriers existing in this context. Throughout the discourse very little attention has been paid to those primarily responsible for this implementation--academic teaching staff. This paper aims to highlight…

  9. Flame Structure and Chemiluminescence Emissions of Inverse Diffusion Flames under Sinusoidally Driven Plasma Discharges

    Directory of Open Access Journals (Sweden)

    Maria Grazia De Giorgi

    2017-03-01

    Full Text Available Reduction of nitric oxides (NOx in aircraft engines and in gas turbines by lean combustion is of great interest in the design of novel combustion systems. However, the stabilization of the flame under lean conditions is a main issue. In this context, the present work investigates the effects of sinusoidal dielectric barrier discharge (DBD on a lean inverse diffusive methane/air flame in a Bunsen-type burner under different actuation conditions. The flame appearance was investigated with fixed methane loading (mass flux, but with varying inner airflow rate. High-speed flame imaging was done by using an intensified (charge-coupled device CCD camera equipped with different optical filters in order to selectively record signals from the chemiluminescent species OH*, CH*, or CO2* to evaluate the flame behavior in presence of plasma actuation. The electrical power consumption was less than 33 W. It was evident that the plasma flame enhancement was significantly influenced by the plasma discharges, particularly at high inner airflow rates. The flame structure changes drastically when the dissipated plasma power increases. The flame area decreases due to the enhancement of mixing and chemical reactions that lead to a more anchored flame on the quartz exit with a reduction of the flame length.

  10. Realisation and advanced engineering of true optical rugate filters based on nanoporous anodic alumina by sinusoidal pulse anodisation

    Science.gov (United States)

    Santos, Abel; Yoo, Jeong Ha; Rohatgi, Charu Vashisth; Kumeria, Tushar; Wang, Ye; Losic, Dusan

    2016-01-01

    This study is the first realisation of true optical rugate filters (RFs) based on nanoporous anodic alumina (NAA) by sinusoidal waves. An innovative and rationally designed sinusoidal pulse anodisation (SPA) approach in galvanostatic mode is used with the aim of engineering the effective medium of NAA in a sinusoidal fashion. A precise control over the different anodisation parameters (i.e. anodisation period, anodisation amplitude, anodisation offset, number of pulses, anodisation temperature and pore widening time) makes it possible to engineer the characteristic reflection peaks and interferometric colours of NAA-RFs, which can be finely tuned across the UV-visible-NIR spectrum. The effect of the aforementioned anodisation parameters on the photonic properties of NAA-RFs (i.e. characteristic reflection peaks and interferometric colours) is systematically assessed in order to establish for the first time a comprehensive rationale towards NAA-RFs with fully controllable photonic properties. The experimental results are correlated with a theoretical model (Looyenga-Landau-Lifshitz - LLL), demonstrating that the effective medium of these photonic nanostructures can be precisely described by the effective medium approximation. NAA-RFs are also demonstrated as chemically selective photonic platforms combined with reflectometric interference spectroscopy (RIfS). The resulting optical sensing system is used to assess the reversible binding affinity between a model drug (i.e. indomethacin) and human serum albumin (HSA) in real-time. Our results demonstrate that this system can be used to determine the overall pharmacokinetic profile of drugs, which is a critical aspect to be considered for the implementation of efficient medical therapies.This study is the first realisation of true optical rugate filters (RFs) based on nanoporous anodic alumina (NAA) by sinusoidal waves. An innovative and rationally designed sinusoidal pulse anodisation (SPA) approach in galvanostatic

  11. Full-Band Quasi-Harmonic Analysis and Synthesis of Musical Instrument Sounds with Adaptive Sinusoids

    Directory of Open Access Journals (Sweden)

    Marcelo Caetano

    2016-05-01

    Full Text Available Sinusoids are widely used to represent the oscillatory modes of musical instrument sounds in both analysis and synthesis. However, musical instrument sounds feature transients and instrumental noise that are poorly modeled with quasi-stationary sinusoids, requiring spectral decomposition and further dedicated modeling. In this work, we propose a full-band representation that fits sinusoids across the entire spectrum. We use the extended adaptive Quasi-Harmonic Model (eaQHM to iteratively estimate amplitude- and frequency-modulated (AM–FM sinusoids able to capture challenging features such as sharp attacks, transients, and instrumental noise. We use the signal-to-reconstruction-error ratio (SRER as the objective measure for the analysis and synthesis of 89 musical instrument sounds from different instrumental families. We compare against quasi-stationary sinusoids and exponentially damped sinusoids. First, we show that the SRER increases with adaptation in eaQHM. Then, we show that full-band modeling with eaQHM captures partials at the higher frequency end of the spectrum that are neglected by spectral decomposition. Finally, we demonstrate that a frame size equal to three periods of the fundamental frequency results in the highest SRER with AM–FM sinusoids from eaQHM. A listening test confirmed that the musical instrument sounds resynthesized from full-band analysis with eaQHM are virtually perceptually indistinguishable from the original recordings.

  12. Neuronal oscillations with non-sinusoidal morphology produce spurious phase-to-amplitude coupling and directionality.

    Directory of Open Access Journals (Sweden)

    Diego Lozano-Soldevilla

    2016-08-01

    Full Text Available Neuronal oscillations support cognitive processing. Modern views suggest that neuronal oscillations do not only reflect coordinated activity in spatially distributed networks, but also that there is interaction between the oscillations at different frequencies. For example, invasive recordings in animals and humans have found that the amplitude of fast oscillations (> 40 Hz occur non-uniformly within the phase of slower oscillations, forming the so-called cross-frequency coupling (CFC. However, the CFC patterns be influenced by features in the signal that do not relate to underlying physiological interactions. For example, CFC estimates may be sensitive to spectral correlations due to non-sinusoidal properties of the alpha band wave morphology. To investigate this issue, we performed CFC analysis using experimental and synthetic data. The former consisted in a double-blind magnetoencephalography pharmacological study in which participants received either placebo, 0.5 mg or 1.5 mg of lorazepam (LZP; GABAergic enhancer in different experimental sessions. By recording oscillatory brain activity with during rest and working memory (WM, we were able to demonstrate that posterior alpha (8 – 12 Hz phase was coupled to beta-low gamma band (20 – 45 Hz amplitude envelope during all sessions. Importantly, bicoherence values around the harmonics of the alpha frequency were similar both in magnitude and topographic distribution to the cross-frequency coherence (CFCoh values observed in the alpha-phase to beta-low gamma coupling. In addition, despite the large CFCoh we found no significant cross-frequency directionality (CFD. Critically, simulations demonstrated that a sizable part of our empirical CFCoh between alpha and beta-low gamma coupling and the lack of CFD could be explained by two-three harmonics aligned in zero phase-lag produced by the physiologically characteristic alpha asymmetry in the amplitude of the peaks relative to the troughs

  13. Implementation of Fisheries Enhancement Opportunities on the Coeur d'Alene Reservation, 2002 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Vitale, Angelo, Lamb, Dave; Scott, Jason

    2003-12-01

    actions included: (1) Implement habitat restoration and enhancement measures in Alder, Benewah, Evans, and Lake Creeks; (2) Purchase critical watershed areas for protection of fisheries habitat; (3) Conduct an educational/outreach program for the general public within the Coeur d'Alene Reservation to facilitate a 'holistic' watershed protection process; (4) Develop an interim fishery for tribal and non-tribal members of the reservation through construction, operation and maintenance of five trout ponds; (5) Design, construct, operate and maintain a trout production facility; and (6) Implement a five-year monitoring program to evaluate the effectiveness of the hatchery and habitat improvement projects. Since that time, much of the mitigation activities occurring within the Coeur d'Alene sub-basin have had a connection to the project entitled 'Implement of Fisheries Enhancement Opportunities on the Coeur d'Alene Reservation', which is sponsored and implemented by the Coeur d'Alene Tribe Fisheries Program and is the subject of this report.

  14. Computationally Efficient Amplitude Modulated Sinusoidal Audio Coding using Frequency-Domain Linear Prediction

    DEFF Research Database (Denmark)

    Christensen, M. G.; Jensen, Søren Holdt

    2006-01-01

    A method for amplitude modulated sinusoidal audio coding is presented that has low complexity and low delay. This is based on a subband processing system, where, in each subband, the signal is modeled as an amplitude modulated sum of sinusoids. The envelopes are estimated using frequency......-domain linear prediction and the prediction coefficients are quantized. As a proof of concept, we evaluate different configurations in a subjective listening test, and this shows that the proposed method offers significant improvements in sinusoidal coding. Furthermore, the properties of the frequency...

  15. Development of an Enhanced Recovery After Surgery Guideline and Implementation Strategy Based on the Knowledge-to-action Cycle.

    Science.gov (United States)

    McLeod, Robin S; Aarts, Mary-Anne; Chung, Frances; Eskicioglu, Cagla; Forbes, Shawn S; Conn, Lesley Gotlib; McCluskey, Stuart; McKenzie, Marg; Morningstar, Beverly; Nadler, Ashley; Okrainec, Allan; Pearsall, Emily A; Sawyer, Jason; Siddique, Naveed; Wood, Trevor

    2015-12-01

    Enhanced Recovery After Surgery (ERAS) protocols have been shown to increase recovery, decrease complications, and reduce length of stay. However, they are difficult to implement. To develop and implement an ERAS clinical practice guideline (CPG) at multiple hospitals. A tailored strategy based on the Knowledge-to-action (KTA) cycle was used to develop and implement an ERAS CPG at 15 academic hospitals in Canada. This included an initial audit to identify gaps and interviews to assess barriers and enablers to implementation. Implementation included development of an ERAS guideline by a multidisciplinary group, communities of practice led by multidiscipline champions (surgeons, anesthesiologists, and nurses) both provincially and locally, educational tools, and clinical pathways as well as audit and feedback. The initial audit revealed there was greater than 75% compliance in only 2 of 18 CPG recommendations. Main themes identified by stakeholders were that the CPG must be based on best evidence, there must be increased communication and collaboration among perioperative team members, and patient education is essential. ERAS and Pain Management CPGs were developed by a multidisciplinary team and have been adopted at all hospitals. Preliminary data from more than 1000 patients show that the uptake of recommended interventions varies but despite this, mean length of stay has decreased with low readmission rates and adverse events. On the basis of short-term findings, our results suggest that a tailored implementation strategy based on the KTA cycle can be used to successfully implement an ERAS program at multiple sites.

  16. Design and implementation of two two-week Teacher Enhancement Institutes

    Science.gov (United States)

    Lambert, Lynn

    1994-01-01

    During this summer, I have been part of a four team effort that planned and executed two two-week Teacher Enhancement Institutes (TEI) for 40 K-8 teachers from this area. The TEI was designed to enhance teachers' background in aeronautics and technology so that they would be better equipped to encourage and to train students in the mathematics, science, and technology fields. The teachers were given a stipend and three graduate credits from Christopher Newport University for their participation in this program. The four ASEE fellows worked together to develop objectives and a schedule of activities for each two-week session based on the program outline given in the grants that were funding this effort. We divided the responsibilities in coordinating and implementing each part of the TEI based on the specific strengths and background of each ASEE fellow. My specific responsibilities were: (1) to develop the course syllabus and generally handle all matters involved with the graduate course; (2) coordinate the follow-up sessions; and (3) design and manage half of the technology sessions that we had scheduled (approximately 30% of the TEI was devoted to technology). Because the first two responsibilities were primarily administrative in nature, I will address only the last. The technology sessions were divided into computer-only and other technologies (e.g., television and digital technology including scanning, digital photography and CD-ROM). I had responsibility for the computer-only technology sessions. The emphasis of these sessions was on use of the Internet specifically to locate and use educational resources. To maximize learning, these sessions were hands-on with two teachers at each computer. Each teacher received instruction in, and actually used, the most popular tools available on the Internet: email (they were given temporary accounts at NASA LaRC), anonymous ftp and archie, gopher and veronica, mosaic, and telnet. Teachers participated in hands

  17. Dynamic performance of maximum power point tracking circuits using sinusoidal extremum seeking control for photovoltaic generation

    Science.gov (United States)

    Leyva, R.; Artillan, P.; Cabal, C.; Estibals, B.; Alonso, C.

    2011-04-01

    The article studies the dynamic performance of a family of maximum power point tracking circuits used for photovoltaic generation. It revisits the sinusoidal extremum seeking control (ESC) technique which can be considered as a particular subgroup of the Perturb and Observe algorithms. The sinusoidal ESC technique consists of adding a small sinusoidal disturbance to the input and processing the perturbed output to drive the operating point at its maximum. The output processing involves a synchronous multiplication and a filtering stage. The filter instance determines the dynamic performance of the MPPT based on sinusoidal ESC principle. The approach uses the well-known root-locus method to give insight about damping degree and settlement time of maximum-seeking waveforms. This article shows the transient waveforms in three different filter instances to illustrate the approach. Finally, an experimental prototype corroborates the dynamic analysis.

  18. Inverse modelling and pulsating torque minimization of salient pole non-sinusoidal synchronous machines

    Energy Technology Data Exchange (ETDEWEB)

    Ait-gougam, Y.; Ibtiouen, R.; Touhami, O. [Laboratoire de Recherche en Electrotechnique, Ecole Nationale Polytechnique, BP 182, El-Harrach 16200 (Algeria); Louis, J.-P.; Gabsi, M. [Systemes et Applications des Technologies de l' Information et de l' Energie (SATIE), CNRS UMR 8029, Ecole Normale Superieure de Cachan, 61 Avenue du President Wilson, 94235 Cachan Cedex (France)

    2008-01-15

    Sinusoidal motor's mathematical models are usually obtained using classical d-q transformation in the case of salient pole synchronous motors having sinusoidal field distribution. In this paper, a new inverse modelling for synchronous motors is presented. This modelling is derived from the properties of constant torque curves in the Concordia's reference frame. It takes into account the non-sinusoidal field distribution; EMF, self and mutual inductances having non-sinusoidal variations with respect to the angular rotor position. Both copper losses and torque ripples are minimized by adapted currents waveforms calculated from this model. Experimental evaluation was carried out on a DSP-controlled PMSM drive platform. Test results obtained demonstrate the effectiveness of the proposed method in reducing torque ripple. (author)

  19. Influence of sinusoidal flow on the thermal and hydraulic performance of microchannel heat sink

    International Nuclear Information System (INIS)

    Om, N I; Gunnasegaran, P; Rajasegaran, S

    2013-01-01

    In this paper, the effect of sinusoidal flow on the thermal and hydraulic performance of microchannel heat sink (MCHS) is numerically investigated. This investigation covers Reynolds number in the range of 100 ≤ Re ≤ 1000 and pure water is used as a working fluid. The three-dimensional steady, laminar flow and heat transfer governing equations are solved using finite volume method (FVM). The water flow field and heat transfer performance inside the sinusoidal microchannels is simulated and the results are compared with the straight microchannels. The effect of using sinusoidal microchannels on temperature distribution, Nusselt number, friction factor and thermal resistance is presented in this paper. It is found that with same rectangular cross-section, sinusoidal microchannels have a better heat transfer performance compared to the straight microchannels.

  20. An optimized method for mouse liver sinusoidal endothelial cell isolation

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, Jeremy, E-mail: jeremy.meyer@hcuge.ch [Division of Digestive and Transplantation Surgery, University Hospitals of Geneva, Rue Gabrielle-Perret-Gentil 4, 1211 Genève 14 (Switzerland); Unit of Surgical Research, University of Geneva, Rue Michel-Servet 1, 1206 Genève (Switzerland); Lacotte, Stéphanie, E-mail: stephanie.lacotte@unige.ch [Unit of Surgical Research, University of Geneva, Rue Michel-Servet 1, 1206 Genève (Switzerland); Morel, Philippe, E-mail: philippe.morel@hcuge.ch [Division of Digestive and Transplantation Surgery, University Hospitals of Geneva, Rue Gabrielle-Perret-Gentil 4, 1211 Genève 14 (Switzerland); Unit of Surgical Research, University of Geneva, Rue Michel-Servet 1, 1206 Genève (Switzerland); Gonelle-Gispert, Carmen, E-mail: carmen.gonelle@unige.ch [Unit of Surgical Research, University of Geneva, Rue Michel-Servet 1, 1206 Genève (Switzerland); Bühler, Léo, E-mail: leo.buhler@hcuge.ch [Division of Digestive and Transplantation Surgery, University Hospitals of Geneva, Rue Gabrielle-Perret-Gentil 4, 1211 Genève 14 (Switzerland); Unit of Surgical Research, University of Geneva, Rue Michel-Servet 1, 1206 Genève (Switzerland)

    2016-12-10

    The objective of the present study was to develop an accurate and reproducible method for liver sinusoidal endothelial cell (LSEC) isolation in mice. Non-parenchymal cells were isolated using a modified two-step collagenase digestion combined with Optiprep density gradient centrifugation. LSEC were further purified using two prevalent methods, short-term selective adherence and CD146+ magnetic-activated cell sorting (MACS), and compared in terms of cell yield, viability and purity to our purification technique using CD11b cell depletion combined with long-term selective adherence. LSEC purification using our technique allowed to obtain 7.07±3.80 million LSEC per liver, while CD146+ MACS and short-term selective adherence yielded 2.94±1.28 and 0.99±0.66 million LSEC, respectively. Purity of the final cell preparation reached 95.10±2.58% when using our method. In contrast, CD146+ MACS and short-term selective adherence gave purities of 86.75±3.26% and 47.95±9.82%, respectively. Similarly, contamination by non-LSEC was the lowest when purification was performed using our technique, with a proportion of contaminating macrophages of only 1.87±0.77%. Further, isolated cells analysed by scanning electron microscopy presented typical LSEC fenestrations organized in sieve plates, demonstrating that the technique allowed to isolate bona fide LSEC. In conclusion, we described a reliable and reproducible technique for the isolation of high yields of pure LSEC in mice. This protocol provides an efficient method to prepare LSEC for studying their biological functions. - Highlights: • This protocol provides an efficient method to prepare primary mouse LSEC for studying their biological functions. • The liver cell dispersion step was improved by performing a retrograde cannulation of the liver. • The cell yield and the purity obtained were higher than comparative techniques in mice. • Contaminating macrophages were removed by introducing a CD11b- magnetic

  1. An optimized method for mouse liver sinusoidal endothelial cell isolation

    International Nuclear Information System (INIS)

    Meyer, Jeremy; Lacotte, Stéphanie; Morel, Philippe; Gonelle-Gispert, Carmen; Bühler, Léo

    2016-01-01

    The objective of the present study was to develop an accurate and reproducible method for liver sinusoidal endothelial cell (LSEC) isolation in mice. Non-parenchymal cells were isolated using a modified two-step collagenase digestion combined with Optiprep density gradient centrifugation. LSEC were further purified using two prevalent methods, short-term selective adherence and CD146+ magnetic-activated cell sorting (MACS), and compared in terms of cell yield, viability and purity to our purification technique using CD11b cell depletion combined with long-term selective adherence. LSEC purification using our technique allowed to obtain 7.07±3.80 million LSEC per liver, while CD146+ MACS and short-term selective adherence yielded 2.94±1.28 and 0.99±0.66 million LSEC, respectively. Purity of the final cell preparation reached 95.10±2.58% when using our method. In contrast, CD146+ MACS and short-term selective adherence gave purities of 86.75±3.26% and 47.95±9.82%, respectively. Similarly, contamination by non-LSEC was the lowest when purification was performed using our technique, with a proportion of contaminating macrophages of only 1.87±0.77%. Further, isolated cells analysed by scanning electron microscopy presented typical LSEC fenestrations organized in sieve plates, demonstrating that the technique allowed to isolate bona fide LSEC. In conclusion, we described a reliable and reproducible technique for the isolation of high yields of pure LSEC in mice. This protocol provides an efficient method to prepare LSEC for studying their biological functions. - Highlights: • This protocol provides an efficient method to prepare primary mouse LSEC for studying their biological functions. • The liver cell dispersion step was improved by performing a retrograde cannulation of the liver. • The cell yield and the purity obtained were higher than comparative techniques in mice. • Contaminating macrophages were removed by introducing a CD11b- magnetic

  2. Enhancing implementation of tobacco use prevention and cessation counselling guideline among dental providers: a cluster randomised controlled trial.

    Science.gov (United States)

    Amemori, Masamitsu; Korhonen, Tellervo; Kinnunen, Taru; Michie, Susan; Murtomaa, Heikki

    2011-02-14

    Tobacco use adversely affects oral health. Tobacco use prevention and cessation (TUPAC) counselling guidelines recommend that healthcare providers ask about each patient's tobacco use, assess the patient's readiness and willingness to stop, document tobacco use habits, advise the patient to stop, assist and help in quitting, and arrange monitoring of progress at follow-up appointments. Adherence to such guidelines, especially among dental providers, is poor. To improve guideline implementation, it is essential to understand factors influencing it and find effective ways to influence those factors. The aim of the present study protocol is to introduce a theory-based approach to diagnose implementation difficulties of TUPAC counselling guidelines among dental providers. Theories of behaviour change have been used to identify key theoretical domains relevant to the behaviours of healthcare providers involved in implementing clinical guidelines. These theoretical domains will inform the development of a questionnaire aimed at assessing the implementation of the TUPAC counselling guidelines among Finnish municipal dental providers. Specific items will be drawn from the guidelines and the literature on TUPAC studies. After identifying potential implementation difficulties, we will design two interventions using theories of behaviour change to link them with relevant behaviour change techniques aiming to improve guideline adherence. For assessing the implementation of TUPAC guidelines, the electronic dental record audit and self-reported questionnaires will be used. To improve guideline adherence, the theoretical-domains approach could provide a comprehensive basis for assessing implementation difficulties, as well as designing and evaluating interventions. After having identified implementation difficulties, we will design and test two interventions to enhance TUPAC guideline adherence. Using the cluster randomised controlled design, we aim to provide further evidence on

  3. Teacher Candidates Implementing Universal Design for Learning: Enhancing Picture Books with QR Codes

    Science.gov (United States)

    Grande, Marya; Pontrello, Camille

    2016-01-01

    The purpose of this study was to investigate if teacher candidates could gain knowledge of the principles of Universal Design for Learning by enhancing traditional picture books with Quick Response (QR) codes and to determine if the process of making these enhancements would impact teacher candidates' comfort levels with using technology on both…

  4. Implementation-intention encoding in a prospective memory task enhances spontaneous retrieval of intentions.

    Science.gov (United States)

    Rummel, Jan; Einstein, Gilles O; Rampey, Hilary

    2012-01-01

    Although forming implementation intentions (Gollwitzer, 1999) has been demonstrated to generally improve prospective memory, the underlying cognitive mechanisms are not completely understood. It has been proposed that implementation-intention encoding encourages spontaneous retrieval (McDaniel & Scullin, 2010). Alternatively one could assume the positive effect of implementation-intention encoding is caused by increased or more efficient monitoring for target cues. To test these alternative explanations and to further investigate the cognitive mechanisms underlying implementation-intention benefits, in two experiments participants formed the intention to respond to specific target cues in a lexical decision task with a special key, but then had to suspend this intention during an intervening word-categorisation task. Response times on trials directly following the occurrence of target cues in the intervening task were significantly slower with implementation-intention encoding than with standard encoding, indicating that spontaneous retrieval was increased (Experiment 1). However, when activation of the target cues was controlled for, similar slowing was found with both standard and implementation-intention encoding (Experiment 2). The results imply that implementation-intention encoding as well as increased target-cue activation foster spontaneous retrieval processes.

  5. Walking strategies of visually impaired people on trapezoidal- and sinusoidal-section tactile groundsurface indicators.

    Science.gov (United States)

    Ranavolo, A; Conte, C; Iavicoli, S; Serrao, M; Silvetti, A; Sandrini, G; Pierelli, F; Draicchio, F

    2011-03-01

    The visual system in walking serves to perceive feedback or feed-forward signals. Therefore, visually impaired persons (VIP) have biased motor control mechanisms. The use of leading indicators (LIs) and long canes helps to improve their walking efficiency. The aims of this study were to compare the walking efficiency of VIP on trapezoidal- and sinusoidal-section LIs using an optoelectronic motion analysis system. VIP displayed a significantly longer stance phase, a shorter swing phase and shorter step and stride lengths when they walked on the sinusoidal LI than when they walked on the trapezoidal LI. Compared with the trapezoidal LI, VIP walking on the sinusoidal LI displayed significantly lower joint ranges of motion. The centre of mass lateral displacement was wider for VIP walking on the sinusoidal LI than on the trapezoidal LI. Some significant differences were also found in sighted persons walking on both LIs. In conclusion, the trapezoidal shape enabled visually impaired subjects to walk more efficiently, whereas the sinusoidal shape caused dynamic balance problems. STATEMENT OF RELEVANCE: These findings suggest that VIP can walk more efficiently, with a lower risk of falls, on trapezoidal-section than on sinusoidal-section LIs. These results should be considered when choosing the most appropriate ground tactile surface indicators for widespread use.

  6. Design and Implementation of an Enhanced 802.11 MAC Architecture for Single-Hop Wireless Networks

    Directory of Open Access Journals (Sweden)

    Ralph Bernasconi

    2007-01-01

    Full Text Available Due to its extreme simplicity and flexibility, the IEEE 802.11 standard is the dominant technology to implement both infrastructure-based WLANs and single-hop ad hoc networks. In spite of its popularity, there is a vast literature demonstrating the shortcomings of using the 802.11 technology in such environments, such as dramatic degradation of network capacity as contention increases and vulnerability to external interferences. Therefore, the design of enhancements and optimizations for the original 802.11 MAC protocol has been a very active research area in the last years. However, all these modifications to the 802.11 MAC protocol were validated only through simulations and/or analytical investigations. In this paper, we present a very unique work as we have designed a flexible hardware/software platform, fully compatible with current implementations of the IEEE 802.11 technology, which we have used to concretely implement and test an enhanced 802.11 backoff algorithm. Our experimental results clearly show that the enhanced mechanism outperforms the standard 802.11 MAC protocol in real scenarios.

  7. Experiences gained from implementing mandatory buffer strips in Denmark: how can we enhance their ecosystem services?

    Science.gov (United States)

    Kronvang, Brian; Hoffmann, Carl Christian; Baattrup-Pedersen, Annette; Hille, Sandra; Rubæk, Gitte; Heckrath, Goswin; Gertz, Flemming; Jensen, Henning; Feuerback, Peter; Strand, John; Stutter, Marc

    2015-04-01

    The Danish Parliament adopted in June 2012 a Buffer Strip Act that required 10 m mandatory buffer strips (BSs) to be established along all watercourses and lakes with a surface area greater than 100 m2 from 1st September 2012. The main reasons for deploying BSs was to reduce nitrate-N leaching and phosphorus (P) loss via surface runoff from adjoining fields from the approximately 50,000 ha of BSs as no farming activities were allowed in the BS concerning use of fertilizer, spreading of manure, spraying with pesticides, etc. Reductions in nutrient losses to watercourses are needed for minimizing the eutrophication effects in lakes and coastal waters. Buffer strips are among the most well studied and frequently adapted mitigation measure for reducing sediment and P losses to surface waters via surface runoff. It has, however, been questioned if BSs can also reduce N losses. The international literature gives an overwhelming support to their functioning for reduction in sediment and especially particulate P losses. However, their functioning for dissolved P and nitrogen is more questionable when comparing studies from the international literature. In Denmark, many farmers were against the introduction of BSs as a general mitigation measure for several reasons. The most used argument in the public debate was that BSs in general are not very efficient for reducing N and P losses to surface waters which was originally the argument behind the BS Act from the Ministries of Environment and Food and Agriculture. A desk study had been made prior to the adaptation of the law that showed 10 m BSs to be able to reduce the N loading with 40-50 kg N ha-1 of BS and 0.04-0.4 kg P ha-1 BS. The total reduction from the BSs established in Denmark in 2012 would then amount to 2,000-2,500 tonnes N and 2-20 tonnes P. The intense public debate in Denmark made the Parliament to adopt a new BS law in June 2014 to be implemented in August 2014 that reduced the total areas with mandatory BSs

  8. Application of discrete choice experiments to enhance stakeholder engagement as a strategy for advancing implementation: a systematic review.

    Science.gov (United States)

    Salloum, Ramzi G; Shenkman, Elizabeth A; Louviere, Jordan J; Chambers, David A

    2017-11-23

    One of the key strategies to successful implementation of effective health-related interventions is targeting improvements in stakeholder engagement. The discrete choice experiment (DCE) is a stated preference technique for eliciting individual preferences over hypothetical alternative scenarios that is increasingly being used in health-related applications. DCEs are a dynamic approach to systematically measure health preferences which can be applied in enhancing stakeholder engagement. However, a knowledge gap exists in characterizing the extent to which DCEs are used in implementation science. We conducted a systematic literature search (up to December 2016) of the English literature to identify and describe the use of DCEs in engaging stakeholders as an implementation strategy. We searched the following electronic databases: MEDLINE, Econlit, PsychINFO, and the CINAHL using mesh terms. Studies were categorized according to application type, stakeholder(s), healthcare setting, and implementation outcome. Seventy-five publications were selected for analysis in this systematic review. Studies were categorized by application type: (1) characterizing demand for therapies and treatment technologies (n = 32), (2) comparing implementation strategies (n = 22), (3) incentivizing workforce participation (n = 11), and (4) prioritizing interventions (n = 10). Stakeholders included providers (n = 27), patients (n = 25), caregivers (n = 5), and administrators (n = 2). The remaining studies (n = 16) engaged multiple stakeholders (i.e., combination of patients, caregivers, providers, and/or administrators). The following implementation outcomes were discussed: acceptability (n = 75), appropriateness (n = 34), adoption (n = 19), feasibility (n = 16), and fidelity (n = 3). The number of DCE studies engaging stakeholders as an implementation strategy has been increasing over the past decade. As DCEs are more widely used as a

  9. A GPU-paralleled implementation of an enhanced face recognition algorithm

    Science.gov (United States)

    Chen, Hao; Liu, Xiyang; Shao, Shuai; Zan, Jiguo

    2013-03-01

    Face recognition algorithm based on compressed sensing and sparse representation is hotly argued in these years. The scheme of this algorithm increases recognition rate as well as anti-noise capability. However, the computational cost is expensive and has become a main restricting factor for real world applications. In this paper, we introduce a GPU-accelerated hybrid variant of face recognition algorithm named parallel face recognition algorithm (pFRA). We describe here how to carry out parallel optimization design to take full advantage of many-core structure of a GPU. The pFRA is tested and compared with several other implementations under different data sample size. Finally, Our pFRA, implemented with NVIDIA GPU and Computer Unified Device Architecture (CUDA) programming model, achieves a significant speedup over the traditional CPU implementations.

  10. Failure Mode and Effect Analysis (FMEA) may enhance implementation of clinical practice guidelines: An experience from the Middle East.

    Science.gov (United States)

    Babiker, Amir; Amer, Yasser S; Osman, Mohamed E; Al-Eyadhy, Ayman; Fatani, Solafa; Mohamed, Sarar; Alnemri, Abdulrahman; Titi, Maher A; Shaikh, Farheen; Alswat, Khalid A; Wahabi, Hayfaa A; Al-Ansary, Lubna A

    2018-02-01

    Implementation of clinical practice guidelines (CPGs) has been shown to reduce variation in practice and improve health care quality and patients' safety. There is a limited experience of CPG implementation (CPGI) in the Middle East. The CPG program in our institution was launched in 2009. The Quality Management department conducted a Failure Mode and Effect Analysis (FMEA) for further improvement of CPGI. This is a prospective study of a qualitative/quantitative design. Our FMEA included (1) process review and recording of the steps and activities of CPGI; (2) hazard analysis by recording activity-related failure modes and their effects, identification of actions required, assigned severity, occurrence, and detection scores for each failure mode and calculated the risk priority number (RPN) by using an online interactive FMEA tool; (3) planning: RPNs were prioritized, recommendations, and further planning for new interventions were identified; and (4) monitoring: after reduction or elimination of the failure mode. The calculated RPN will be compared with subsequent analysis in post-implementation phase. The data were scrutinized from a feedback of quality team members using a FMEA framework to enhance the implementation of 29 adapted CPGs. The identified potential common failure modes with the highest RPN (≥ 80) included awareness/training activities, accessibility of CPGs, fewer advocates from clinical champions, and CPGs auditing. Actions included (1) organizing regular awareness activities, (2) making CPGs printed and electronic copies accessible, (3) encouraging senior practitioners to get involved in CPGI, and (4) enhancing CPGs auditing as part of the quality sustainability plan. In our experience, FMEA could be a useful tool to enhance CPGI. It helped us to identify potential barriers and prepare relevant solutions. © 2017 John Wiley & Sons, Ltd.

  11. Using a Commercial Framework to Implement and Enhance the IEEE 1451.1 Standard

    OpenAIRE

    Viegas, Vítor; Pereira, José Dias; Girão, P. Silva

    2005-01-01

    In 1999, the 1451.1 Std was published defining a common object model and interface specification to develop open, multi-vendor distributed measurement and control systems. However, despite the well-known advantages of the model, few have been the initiatives to implement it. In this paper we describe the implementation of a NCAP – Network Capable Application Processor, in a well-known and well-proven infrastructure: the Microsoft .NET Framework. The choice of a commercial framework was part o...

  12. Implementation of intra-cavity beam shaping technique to enhance pump efficiency

    CSIR Research Space (South Africa)

    Litvin, IA

    2012-02-01

    Full Text Available In this work the author proposes an implementation of a new intra-cavity beam shaping technique to vary the intensity distribution of the fundamental mode in a resonator cavity while maintaining a constant intensity distribution at the output...

  13. Implementing "Marketing Me": A Simulation Enhanced Variant for a Student Self-Marketing Exercise

    Science.gov (United States)

    Flostrand, Andrew; Ho, Jason Y. C.; Krider, Robert E.

    2016-01-01

    The use of student self-branding exercises in introductory marketing courses for undergraduate business programs has been growing in popularity due to a number of advantages for students. This article introduces implementation of the "Marketing Me" variant developed and used since 2013 by the authors, wherein alumni are brought in to…

  14. Using group learning to enhance the implementation of information technology : The results of discourse analysis

    NARCIS (Netherlands)

    Bondarouk, Tatiana

    2004-01-01

    This thesis is about the influence of group interactional processes on the implementation of information technologies. The starting point of this research is the belief that it is neither the quality of the technology, nor that of the individual users, but the interactions among people in groups of

  15. Designing and Implementing Web-Based Scaffolding Tools for Technology-Enhanced Socioscientific Inquiry

    Science.gov (United States)

    Shin, Suhkyung; Brush, Thomas A.; Glazewski, Krista D.

    2017-01-01

    This study explores how web-based scaffolding tools provide instructional support while implementing a socio-scientific inquiry (SSI) unit in a science classroom. This case study focused on how students used web-based scaffolding tools during SSI activities, and how students perceived the SSI unit and the scaffolding tools embedded in the SSI…

  16. Design, Implementation, and Characterization of a Dedicated Breast Computed Mammotomography System for Enhanced Lesion Imaging

    National Research Council Canada - National Science Library

    McKinley, Randolph L

    2006-01-01

    .... Half cone-beam orbits have been implemented and investigated and have indicated they are feasible for a wide range of breast sizes. Future studies will focus on characterizing the system in terms of dose efficiency, contrast sensitivity, and evaluation for a range of breast sizes and compositions. Patient bed optimization will also be investigated.

  17. Enhancing Architecture-Implementation Conformance with Change Management and Support for Behavioral Mapping

    Science.gov (United States)

    Zheng, Yongjie

    2012-01-01

    Software architecture plays an increasingly important role in complex software development. Its further application, however, is challenged by the fact that software architecture, over time, is often found not conformant to its implementation. This is usually caused by frequent development changes made to both artifacts. Against this background,…

  18. 77 FR 15263 - Approval and Promulgation of Implementation Plans; New Jersey; Motor Vehicle Enhanced Inspection...

    Science.gov (United States)

    2012-03-15

    ... 2500 Revolutions per Minute (RPM) tests. The TSI test is a tailpipe test which checks the vehicle's... of the program and technology changes that were implemented in the years following the 80 percent... requirements of Section 12(d) of the National Technology Transfer and Advancement Act of 1995 (15 U.S.C. 272...

  19. An organizational framework and strategic implementation for system-level change to enhance research-based practice: QUERI Series

    Directory of Open Access Journals (Sweden)

    Mittman Brian S

    2008-05-01

    Full Text Available Abstract Background The continuing gap between available evidence and current practice in health care reinforces the need for more effective solutions, in particular related to organizational context. Considerable advances have been made within the U.S. Veterans Health Administration (VA in systematically implementing evidence into practice. These advances have been achieved through a system-level program focused on collaboration and partnerships among policy makers, clinicians, and researchers. The Quality Enhancement Research Initiative (QUERI was created to generate research-driven initiatives that directly enhance health care quality within the VA and, simultaneously, contribute to the field of implementation science. This paradigm-shifting effort provided a natural laboratory for exploring organizational change processes. This article describes the underlying change framework and implementation strategy used to operationalize QUERI. Strategic approach to organizational change QUERI used an evidence-based organizational framework focused on three contextual elements: 1 cultural norms and values, in this case related to the role of health services researchers in evidence-based quality improvement; 2 capacity, in this case among researchers and key partners to engage in implementation research; 3 and supportive infrastructures to reinforce expectations for change and to sustain new behaviors as part of the norm. As part of a QUERI Series in Implementation Science, this article describes the framework's application in an innovative integration of health services research, policy, and clinical care delivery. Conclusion QUERI's experience and success provide a case study in organizational change. It demonstrates that progress requires a strategic, systems-based effort. QUERI's evidence-based initiative involved a deliberate cultural shift, requiring ongoing commitment in multiple forms and at multiple levels. VA's commitment to QUERI came in the

  20. Grid-interfacing converter systems with enhanced voltage quality for microgrid application : concept and implementation

    NARCIS (Netherlands)

    Wang, F.; Duarte, J.L.; Hendrix, M.A.M.

    2011-01-01

    Grid-interfacing converter systems with enhanced voltage quality are proposed for microgrid application in this paper. By adapting the conventional series-parallel structure, a group of grid-interfacing system topologies are proposed for the purpose of interfacing local generation/microgrid to the

  1. A mixed methods study of foreign language teachers implementing technology-enhanced multimedia instructio

    Directory of Open Access Journals (Sweden)

    Olha Ketsman

    2014-08-01

    Full Text Available Technology-enhanced multimedia instruction offers benefits for foreign language learners. Despite having much potential, technology itself is neither effective or nor effective, but teachers play a key role in determining its effectiveness because they are in charge of making instructional decisions and choose whether and how to use technology. This article fills a gap in the literature by reporting findings of a mixed methods study of technology- enhanced multimedia instruction in middle and high school foreign language classrooms. Convergent parallel mixed methods design was applied in this study and data was collected through quantitative survey and qualitative semi-structured interviews with teachers. Results from the study indicated a significant positive correlation between variables that contribute to the use of technology-enhanced multimedia instruction in foreign language classrooms and described effective technology-enhanced multimedia practices. The findings of the study have implications for teachers, administrators and faculty of teacher preparation programs as well as state teacher education policy makers.

  2. Electronically Tunable Quadrature Sinusoidal Oscillator with Equal Output Amplitudes during Frequency Tuning Process

    Directory of Open Access Journals (Sweden)

    Den Satipar

    2017-01-01

    Full Text Available A new configuration of voltage-mode quadrature sinusoidal oscillator is proposed. The proposed oscillator employs two voltage differencing current conveyors (VDCCs, two resistors, and two grounded capacitors. In this design, the use of multiple/dual output terminal active building block is not required. The tuning of frequency of oscillation (FO can be done electronically by adjusting the bias current of active device without affecting condition of oscillation (CO. The electronic tuning can be done by controlling the bias current using a digital circuit. The amplitude of two sinusoidal outputs is equal when the frequency of oscillation is tuned. This makes the sinusoidal output voltages meet good total harmonic distortions (THD. Moreover, the proposed circuit can provide the sinusoidal output current with high impedance which is connected to external load or to another circuit without the use of buffer device. To confirm that the oscillator can generate the quadrature sinusoidal output signal, the experimental results using VDCC constructed from commercially available ICs are also included. The experimental results agree well with theoretical anticipation.

  3. A comparison of two coaching approaches to enhance implementation of a recovery-oriented service model.

    Science.gov (United States)

    Deane, Frank P; Andresen, Retta; Crowe, Trevor P; Oades, Lindsay G; Ciarrochi, Joseph; Williams, Virginia

    2014-09-01

    Moving to recovery-oriented service provision in mental health may entail retraining existing staff, as well as training new staff. This represents a substantial burden on organisations, particularly since transfer of training into practice is often poor. Follow-up supervision and/or coaching have been found to improve the implementation and sustainment of new approaches. We compared the effect of two coaching conditions, skills-based and transformational coaching, on the implementation of a recovery-oriented model following training. Training followed by coaching led to significant sustained improvements in the quality of care planning in accordance with the new model over the 12-month study period. No interaction effect was observed between the two conditions. However, post hoc analyses suggest that transformational coaching warrants further exploration. The results support the provision of supervision in the form of coaching in the implementation of a recovery-oriented service model, and suggest the need to better elucidate the mechanisms within different coaching approaches that might contribute to improved care.

  4. Enhancing implementation of tobacco use prevention and cessation counselling guideline among dental providers: a cluster randomised controlled trial

    Directory of Open Access Journals (Sweden)

    Michie Susan

    2011-02-01

    Full Text Available Abstract Background Tobacco use adversely affects oral health. Tobacco use prevention and cessation (TUPAC counselling guidelines recommend that healthcare providers ask about each patient's tobacco use, assess the patient's readiness and willingness to stop, document tobacco use habits, advise the patient to stop, assist and help in quitting, and arrange monitoring of progress at follow-up appointments. Adherence to such guidelines, especially among dental providers, is poor. To improve guideline implementation, it is essential to understand factors influencing it and find effective ways to influence those factors. The aim of the present study protocol is to introduce a theory-based approach to diagnose implementation difficulties of TUPAC counselling guidelines among dental providers. Methods Theories of behaviour change have been used to identify key theoretical domains relevant to the behaviours of healthcare providers involved in implementing clinical guidelines. These theoretical domains will inform the development of a questionnaire aimed at assessing the implementation of the TUPAC counselling guidelines among Finnish municipal dental providers. Specific items will be drawn from the guidelines and the literature on TUPAC studies. After identifying potential implementation difficulties, we will design two interventions using theories of behaviour change to link them with relevant behaviour change techniques aiming to improve guideline adherence. For assessing the implementation of TUPAC guidelines, the electronic dental record audit and self-reported questionnaires will be used. Discussion To improve guideline adherence, the theoretical-domains approach could provide a comprehensive basis for assessing implementation difficulties, as well as designing and evaluating interventions. After having identified implementation difficulties, we will design and test two interventions to enhance TUPAC guideline adherence. Using the cluster

  5. Upregulation of miR21 and repression of Grhl3 by leptin mediates sinusoidal endothelial injury in experimental nonalcoholic steatohepatitis.

    Directory of Open Access Journals (Sweden)

    Sahar Pourhoseini

    Full Text Available Sinusoidal endothelial dysfunction (SED has been found to be an early event in nonalcoholic steatohepatitis (NASH progression but the molecular mechanisms underlying its causation remains elusive. We hypothesized that adipokine leptin worsens sinusoidal injury by decreasing functionally active nitric oxide synthase 3 (NOS3 via miR21. Using rodent models of NASH, and transgenic mice lacking leptin and leptin receptor, results showed that hyperleptinemia caused a 4-5 fold upregulation of hepatic miR21 as assessed by qRTPCR. The upregulation of miR21 led to a time-dependent repression of its target protein Grhl3 levels as shown by western blot analyses. NOS3-p/NOS3 ratio which is controlled by Grhl3 was significantly decreased in NASH models. SED markers ICAM-1, VEGFR-2, and E-selectin as assessed by immunofluorescence microscopy were significantly up regulated in the progressive phases of NASH. Lack of leptin or its receptor in vivo, reversed the upregulation of miR21 and restored the levels of Grhl3 and NOS3-p/NOS3 ratio coupled with decreased SED dysfunction markers. Interestingly, leptin supplementation in mice lacking leptin, significantly enhanced miR21 levels, decreased Grhl3 repression and NOS3 phosphorylation. Leptin supplementation in isolated primary endothelial cells, Kupffer cells and stellate cells showed increased mir21 expression in stellate cells while sinusoidal injury was significantly higher in all cell types. Finally miR21 KO mice showed increased NOS3-p/NOS3 ratio and reversed SED markers in the rodent models of NASH. The experimental results described here show a close association of leptin-induced miR21 in aiding sinusoidal injury in NASH.

  6. Implementing Outcome Measures Within an Enhanced Palliative Care Day Care Model.

    LENUS (Irish Health Repository)

    Kilonzo, Isae

    2015-04-23

    Specialist palliative care day care (SPDC) units provide an array of services to patients and their families and can increase continuity of care between inpatient and homecare settings. A multidisciplinary teamwork approach is emphasized, and different models of day care exist. Depending on the emphasis of care, the models can be social, medical, therapeutic, or mixed. We describe our experience of introducing an enhanced therapeutic specialist day care model and using both patient- and carer-rated tools to monitor patient outcomes.

  7. Design and Implementation of NTU Wearable Exoskeleton as an Enhancement and Assistive Device

    OpenAIRE

    Low, K. H.; Liu, X.; Yu, H.

    2006-01-01

    This article presents a wearable lower extremity exoskeleton (LEE) developed to enhance the ability of a human’s walking while carrying heavy loads. The ultimate goal of the current research work is to design and control a power assist system that integrates a human’s intellect for feedback and sensory purposes. The exoskeleton system in this work consists of an inner exoskeleton and an outer exoskeleton. The inner exoskeleton measures the movements of the wearer and provides these measuremen...

  8. IMPLEMENTATION OF TECHNOLOGY ENHANCED LEARNING PEDAGOGY AND IMPACT ON EMPLOYABILITY AND LEARNING WITHIN ENGINEERING EDUCATION FRAMEWORKS

    OpenAIRE

    Vickerstaff, Rebecca

    2015-01-01

    Engineering Education experiences turbulent changes, both from government pressures and from industry demands on readdressing the requirements of graduate capability. Despite vast amounts of engineering literature discussing ‘change’ within the field, engineering curricula still maintains its predominant pedagogic model of dissemination to students as it did in previous decades. Technology Enhanced Learning in education has created new and flexible options in the delivery and assessmen...

  9. Implementation Authentic Task to Enhance Problem Solving and Self-Management for Physics College Students

    Science.gov (United States)

    Festiyed; Djamas, D.; Pilendia, D.

    2018-04-01

    The purpose of this study is to enhance the problem solving and self-management abilities of student teachers through individual and group authentic task. Preliminary results showed that the learning outcomes in high category, nevertheless problem solving and self-management abilities are still low and average categories (scattered at interval 40 ≤ N ≤ 65). Initiative to improve this condition is needed. Action research is the alternative solution for that condition through planning, acting, evaluating, and reflecting. This study is allowed in 4 cycles. The acting step result with integrated discuss method, case study, and presentation including self-assessment for individual and group. This method was effective to enhance problem solving and self-management abilities. The final learning outcomes seen from the correlation between student self-assessment and lecture-assessment (r=0.19). Its means there are unidirectional relationship between the result of self-assessment and lecture-assessment. The Conclusion of the research was effective to enhance problem solving and self-management ability.

  10. Generic Science Skills Enhancement of Students through Implementation of IDEAL Problem Solving Model on Genetic Information Course

    Science.gov (United States)

    Zirconia, A.; Supriyanti, F. M. T.; Supriatna, A.

    2018-04-01

    This study aims to determine generic science skills enhancement of students through implementation of IDEAL problem-solving model on genetic information course. Method of this research was mixed method, with pretest-posttest nonequivalent control group design. Subjects of this study were chemistry students enrolled in biochemistry course, consisted of 22 students in the experimental class and 19 students in control class. The instrument in this study was essayed involves 6 indicators generic science skills such as indirect observation, causality thinking, logical frame, self-consistent thinking, symbolic language, and developing concept. The results showed that genetic information course using IDEAL problem-solving model have been enhancing generic science skills in low category with of 20,93%. Based on result for each indicator, showed that there are indicators of generic science skills classified in the high category.

  11. Implementation literacy strategies on health technology theme Learning to enhance Indonesian Junior High School Student's Physics Literacy

    Science.gov (United States)

    Feranie, Selly; Efendi, Ridwan; Karim, Saeful; Sasmita, Dedi

    2016-08-01

    The PISA results for Indonesian Students are lowest among Asian countries in the past two successive results. Therefore various Innovations in science learning process and its effectiveness enhancing student's science literacy is needed to enrich middle school science teachers. Literacy strategies have been implemented on health technologies theme learning to enhance Indonesian Junior high school Student's Physics literacy in three different health technologies e.g. Lasik surgery that associated with application of Light and Optics concepts, Ultra Sonographer (USG) associated with application of Sound wave concepts and Work out with stationary bike and walking associated with application of motion concepts. Science learning process involves at least teacher instruction, student learning and a science curriculum. We design two main part of literacy strategies in each theme based learning. First part is Integrated Reading Writing Task (IRWT) is given to the students before learning process, the second part is scientific investigation learning process design packed in Problem Based Learning. The first part is to enhance student's science knowledge and reading comprehension and the second part is to enhance student's science competencies. We design a transformation from complexity of physics language to Middle school physics language and from an expensive and complex science investigation to a local material and simply hands on activities. In this paper, we provide briefly how literacy strategies proposed by previous works is redesigned and applied in classroom science learning. Data were analysed using t- test. The increasing value of mean scores in each learning design (with a significance level of p = 0.01) shows that the implementation of this literacy strategy revealed a significant increase in students’ physics literacy achievement. Addition analysis of Avarage normalized gain show that each learning design is in medium-g courses effectiveness category

  12. New Canonic Active RC Sinusoidal Oscillator Circuits Using Second-Generation Current Conveyors with Application as a Wide-Frequency Digitally Controlled Sinusoid Generator

    OpenAIRE

    Abhirup Lahiri

    2011-01-01

    This paper reports two new circuit topologies using second-generation current conveyors (CCIIs) for realizing variable frequency sinusoidal oscillators with minimum passive components. The proposed topologies in this paper provide new realizations of resistance-controlled and capacitor-controlled variable frequency oscillators (VFOs) using only four passive components. The first topology employs three CCIIs, while the second topology employs two CCIIs. The second topology provides an advantag...

  13. Light scattering by sinusoidal surfaces: illumination windows and harmonics in standards.

    Science.gov (United States)

    Marx, E; Lettieri, T R; Vorburger, T V

    1995-03-01

    Sinusoidal surfaces can be used as material standards to help calibrate instruments that measure the angular distribution of the intensity of light scattered by arbitrary surfaces, because the power in the diffraction peaks varies over several orders of magnitude. The calculated power in the higher-order diffraction peaks from sinusoidal surfaces expressed in terms of Bessel functions is much smaller than the values determined from angular distributions that are measured or computed from measured profiles, both of which are determined mainly by the harmonic contents of the profile. The finite size of the illuminated area, represented by an illumination window, gives rise to a background that is much larger than the calculated power in the higher-order peaks. For a rectangular window of a size equal to an even number of periods of the sinusoid, a computation of the power distribution produces minima at or near the location of the diffraction angles for higher-order diffraction angles.

  14. Enhanced Recovery After Surgery Program Implementation in 2 Surgical Populations in an Integrated Health Care Delivery System.

    Science.gov (United States)

    Liu, Vincent X; Rosas, Efren; Hwang, Judith; Cain, Eric; Foss-Durant, Anne; Clopp, Molly; Huang, Mengfei; Lee, Derrick C; Mustille, Alex; Kipnis, Patricia; Parodi, Stephen

    2017-07-19

    Novel approaches to perioperative surgical care focus on optimizing nutrition, mobility, and pain management to minimize adverse events after surgical procedures. To evaluate the outcomes of an enhanced recovery after surgery (ERAS) program among 2 target populations: patients undergoing elective colorectal resection and patients undergoing emergency hip fracture repair. A pre-post difference-in-differences study before and after ERAS implementation in the target populations compared with contemporaneous surgical comparator groups (patients undergoing elective gastrointestinal surgery and emergency orthopedic surgery). Implementation began in February and March 2014 and concluded by the end of 2014 at 20 medical centers within the Kaiser Permanente Northern California integrated health care delivery system. A multifaceted ERAS program designed with a particular focus on perioperative pain management, mobility, nutrition, and patient engagement. The primary outcome was hospital length of stay. Secondary outcomes included hospital mortality, home discharge, 30-day readmission rates, and complication rates. The study included a total of 3768 patients undergoing elective colorectal resection (mean [SD] age, 62.7 [14.1] years; 1812 [48.1%] male) and 5002 patients undergoing emergency hip fracture repair (mean [SD] age, 79.5 [11.8] years; 1586 [31.7%] male). Comparator surgical patients included 5556 patients undergoing elective gastrointestinal surgery and 1523 patients undergoing emergency orthopedic surgery. Most process metrics had significantly greater changes in the ERAS target populations after implementation compared with comparator surgical populations, including those for ambulation, nutrition, and opioid use. Hospital length of stay and postoperative complication rates were also significantly lower among ERAS target populations after implementation. The rate ratios for postoperative complications were 0.68 (95% CI, 0.46-0.99; P = .04) for patients

  15. Application of discrete choice experiments to enhance stakeholder engagement as a strategy for advancing implementation: a systematic review

    Directory of Open Access Journals (Sweden)

    Ramzi G. Salloum

    2017-11-01

    Full Text Available Abstract Background One of the key strategies to successful implementation of effective health-related interventions is targeting improvements in stakeholder engagement. The discrete choice experiment (DCE is a stated preference technique for eliciting individual preferences over hypothetical alternative scenarios that is increasingly being used in health-related applications. DCEs are a dynamic approach to systematically measure health preferences which can be applied in enhancing stakeholder engagement. However, a knowledge gap exists in characterizing the extent to which DCEs are used in implementation science. Methods We conducted a systematic literature search (up to December 2016 of the English literature to identify and describe the use of DCEs in engaging stakeholders as an implementation strategy. We searched the following electronic databases: MEDLINE, Econlit, PsychINFO, and the CINAHL using mesh terms. Studies were categorized according to application type, stakeholder(s, healthcare setting, and implementation outcome. Results Seventy-five publications were selected for analysis in this systematic review. Studies were categorized by application type: (1 characterizing demand for therapies and treatment technologies (n = 32, (2 comparing implementation strategies (n = 22, (3 incentivizing workforce participation (n = 11, and (4 prioritizing interventions (n = 10. Stakeholders included providers (n = 27, patients (n = 25, caregivers (n = 5, and administrators (n = 2. The remaining studies (n = 16 engaged multiple stakeholders (i.e., combination of patients, caregivers, providers, and/or administrators. The following implementation outcomes were discussed: acceptability (n = 75, appropriateness (n = 34, adoption (n = 19, feasibility (n = 16, and fidelity (n = 3. Conclusions The number of DCE studies engaging stakeholders as an implementation strategy has been increasing over the

  16. Implementation of Enterprise Risk Management (ERM Framework in Enhancing Business Performances in Oil and Gas Sector

    Directory of Open Access Journals (Sweden)

    Sanmugam Annamalah

    2018-01-01

    Full Text Available This study empirically investigated the ERM Implementation model and proposed framework to identify and manage risks in Oil and Gas Sector in Malaysia. The study examined the role of ERM framework implementation in improving business performance by utilizing Economic Value Added as a measurement tool. The study also provides insights to the Oil and Gas Sector to gain higher profit returns, reduce cost of capital, and improve shareholders value. Moreover, it contributes significantly in the field of Enterprise risk management in Malaysia. The identification and management of risk is significant to organizations in managing risks efficiently. Expectations of stakeholders of the organization are high from executives and board of directors in managing the risk effectively. Linear regression analysis is utilized in analyzing the data obtained from the data collection performed for this paper. Purposive sampling has been employed in order to select the firms that are operating in Malaysian oil and gas sector. Primary data has been utilized to collect data with the help of structured questions and interview techniques that involve semi structured questions. The results of the regression analysis conducted for in this study suggested that a significant and positive relationship between Enterprise Risk Management with operational risk; market risk; political risk; health, safety and environmental risk; and, also business performance.

  17. Estimation of the second heart sound split using windowed sinusoidal models

    DEFF Research Database (Denmark)

    Sæderup, Rasmus Gundorf; Hoang, Poul; Winther, Simon

    2018-01-01

    to the potential overlap between A2 and P2. In this paper, a model-based approach is proposed where both A2 and P2 are modeled as windowed sinusoids with their sum forming the S2 signal. Estimation of the model parameters and the S2 split form a non-convex optimization problem, where a local minimum is obtained...... using a sequential optimization procedure. First, the window parameters are found as the solution to a regularized least squares problem. Then, the frequencies and phases of the sinusoids are found by locating the maximal peaks of the heart signals’ frequency magnitudes, and using the corresponding...

  18. Implementation of molecularly imprinted polymer beads for surface enhanced Raman detection.

    Science.gov (United States)

    Kamra, Tripta; Zhou, Tongchang; Montelius, Lars; Schnadt, Joachim; Ye, Lei

    2015-01-01

    Molecularly imprinted polymers (MIPs) have a predesigned molecular recognition capability that can be used to build robust chemical sensors. MIP-based chemical sensors allow label-free detection and are particularly interesting due to their simple operation. In this work we report the use of thiol-terminated MIP microspheres to construct surfaces for detection of a model organic analyte, nicotine, by surface enhanced Raman scattering (SERS). The nicotine-imprinted microspheres are synthesized by RAFT precipitation polymerization and converted into thiol-terminated microspheres through aminolysis. The thiol groups on the MIP surface allow the microspheres to be immobilized on a gold-coated substrate. Three different strategies are investigated to achieve surface enhanced Raman scattering in the vicinity of the imprinted sites: (1) direct sputtering of gold nanoparticles, (2) immobilization of gold colloids through the MIP's thiol groups, and (3) trapping of the MIP microspheres in a patterned SERS substrate. For the first time we show that large MIP microspheres can be turned into selective SERS surfaces through the three different approaches of assembly. The MIP-based sensing surfaces are used to detect nicotine to demonstrate the proof of concept. As synthesis and surface functionalization of MIP microspheres and nanoparticles are well established, the methods reported in this work are handy and efficient for constructing label-free chemical sensors, in particular for those based on SERS detection.

  19. Enhanced model for integrated simulation of an entrained bed gasifier implemented as Aspen Hysys extension

    Energy Technology Data Exchange (ETDEWEB)

    Perez-Fortes, M; Bojarski, A; Ferrer-Nadal, S; Kopanos, G; Mitta, N; Pinilla, C A; Nougues, J M; Velo, E; Puigjaner, L [Universitat Politecnica de Catalunya, Barcelona (Spain). Dept. of Chemical Engineering-CEPIMA

    2007-07-01

    In this work an enhanced mathematical model of an entrained bed gasifier has been developed for improved synthesis gas production. The gasification model considers five stages: pyrolysis, volatiles combustion, char combustion, gasification and a final gas equilibrium zone. Mathematical simulations are carried out to help finding out feasible operating conditions of the process to achieve improved process performance. Visual Basic (VB) is tested as tool for modelling, by using the Aspen Hysys Extension (AHE) interface standards. This standard provides a suitable environment for this purpose, since it allows the creation of completely custom modules which are easy to plug and use thus facilitating the handling of complex models ready to interact with commercial simulation platforms. In this work, integration of different models is accomplished in Aspen Hysys (AH), which provides the basic connectivity within models components, and the thermodynamic framework needed. The integrated modules simulation environment platform uses data from ELCOGAS for validation purposes with excellent preliminary results. 9 refs., 2 figs.

  20. Withania somnifera: Advances and Implementation of Molecular and Tissue Culture Techniques to Enhance Its Application

    Directory of Open Access Journals (Sweden)

    Vibha Pandey

    2017-08-01

    Full Text Available Withania somnifera, commonly known as Ashwagandha an important medicinal plant largely used in Ayurvedic and indigenous medicine for over 3,000 years. Being a medicinal plant, dried powder, crude extract as well as purified metabolies of the plant has shown promising therapeutic properties. Withanolides are the principal metabolites, responsible for the medicinal properties of the plant. Availability and amount of particular withanolides differ with tissue type and chemotype and its importance leads to identification characterization of several genes/ enzymes related to withanolide biosynthetic pathway. The modulation in withanolides can be achieved by controlling the environmental conditions like, different tissue culture techniques, altered media compositions, use of elicitors, etc. Among all the in vitro techniques, hairy root culture proved its importance at industrial scale, which also gets benefits due to more accumulation (amount and number of withanolides in roots tissues of W. somnifera. Use of media compostion and elicitors further enhances the amount of withanolides in hairy roots. Another important modern day technique used for accumulation of desired secondary metabolites is modulating the gene expression by altering environmental conditions (use of different media composition, elicitors, etc. or through genetic enginnering. Knowing the significance of the gene and the key enzymatic step of the pathway, modulation in withanolide contents can be achieved upto required amount in therapeutic industry. To accomplish maximum productivity through genetic enginnering different means of Withania transformation methods have been developed to obtain maximum transformation efficiency. These standardized transformation procedues have been used to overexpress/silence desired gene in W. somnifera to understand the outcome and succeed with enhanced metabolic production for the ultimate benefit of human race.

  1. [The implementation of the method of enhanced external counter pulsation for the treatment of cardiovascular diseases].

    Science.gov (United States)

    Badtieva, V A; Voroshilova, D N

    2018-05-21

    The cardiovascular diseases occupy a leading place in the structure of overall morbidity affecting the population not only of Russia but also of the majority of the developed countries throughout the world; they thus impose the heavy social and economic burden on both the public healthcare services and the modern society in general. At the same time, systemic atherosclerosis is considered to be one of the most common, severe, and life-threatening condition. Despite the presence of a large number of pharmaceutical and surgical methods for the treatment of this pathology, they are not infrequently lacking the desired effectiveness. The use of the shunting operations and endovascular methods failed to radically resolve the problem of managing systemic atherosclerosis and atherosclerosis of the lower limbs. A relatively novel approach which currently begins to find the ever increasing application for the treatment of patients presenting with cardiovascular pathology is based on the enhanced external counter-pulsation method although both the clinical and theoretical prerequisites of its application were developed rather long ago. This non-invasive therapeutic method allows to increase the perfusion pressure in the coronary arteries in diastole and to reduce the resistance to the cardiac ejection in the systole. The objective of this review article was to perform the analysis of the available literature publications on the use of the enhanced external counter-pulsation technique for the treatment of the patients presenting with the diseases of the cardiovascular system and to evaluate the clinical effectiveness of this approach as well as the availability of the treatment for the patients.

  2. A qualitative study to understand the barriers and enablers in implementing an enhanced recovery after surgery program.

    Science.gov (United States)

    Pearsall, Emily A; Meghji, Zahida; Pitzul, Kristen B; Aarts, Mary-Anne; McKenzie, Marg; McLeod, Robin S; Okrainec, Allan

    2015-01-01

    Explore the barriers and enablers to adoption of an Enhanced Recovery after Surgery (ERAS) program by the multidisciplinary perioperative team responsible for the care of elective colorectal surgical patients. ERAS programs include perioperative interventions that when used together have led to decreased length of stay while increasing patient recovery and satisfaction. Despite the known benefits of ERAS programs, uptake remains slow. Semistructured interviews were conducted with general surgeons, anesthesiologists, and ward nurses at 7 University of Toronto-affiliated hospitals to identify potential barriers and enablers to adoption of 18 ERAS interventions. Grounded theory was used to thematically analyze the transcribed interviews. Nineteen general surgeons, 18 anesthesiologists, and 18 nurses participated. The mean time of each interview was 18 minutes. Lack of manpower, poor communication and collaboration, resistance to change, and patient factors were cited by most as barriers. Discipline-specific issues were identified although most related to resistance to change. Overall, interviewees were supportive of implementation of a standardized ERAS program and agreed that a standardized guideline based on best evidence; standardized order sets; and education of the staff, patients, and families are essential. Multidisciplinary perioperative staff supported the implementation of an ERAS program at the University of Toronto-affiliated hospitals. However, major barriers were identified, including the need for patient education, increased communication and collaboration, and better evidence for ERAS interventions. Identifying these barriers and enablers is the first step toward successfully implementing an ERAS program.

  3. Implementation of an Educational Cartoon ("the Patchbook") and Other Compliance-Enhancing Measures by Orthoptists in Occlusion Treatment of Amblyopia.

    Science.gov (United States)

    Tjiam, A M; Asjes-Tydeman, W L; Holtslag, G; Vukovic, E; Sinoo, M M; Loudon, S E; Passchier, J; de Koning, H J; Simonsz, H J

    2016-09-01

    This implementation study evaluated orthoptists' use of an educational cartoon ("the Patchbook") and other measures to improve compliance with occlusion therapy for amblyopia. Participating orthoptists provided standard orthoptic care for one year, adding the Patchbook in the second year. They attended courses on compliance and intercultural communication by communication skills training. Many other compliance-enhancing measures were initiated. Orthoptists' awareness, attitude, and activities regarding noncompliance were assessed through interviews, questionnaires, and observations. Their use of the Patchbook was measured. The study was performed in low socio-economic status (SES) areas and in other areas in the Netherlands. It was attempted to integrate education on compliance into basic and continuing orthoptic training. The Patchbook was used by all 9 orthoptists who participated in low-SES areas and 17 of 23 orthoptists in other areas. Courses changed awareness and attitude about compliance, but this was not sustained. Although orthoptists estimated compliance during patching at 70%, three-quarters never suspected noncompliance during a full day of observation in any of their patients. Explanations to parents who spoke Dutch poorly were short. In the second year, explanations to children were longer. Implementation of all 7 additional compliance-enhancing measures failed. Education on compliance was not integrated into orthoptists' training. Almost all orthoptists used the Patchbook and, as another study demonstrated, it proved to be very effective, especially in low-SES areas. Duration of explanation was inversely proportional to parents' fluency in Dutch. Noncompliance was rarely suspected by orthoptists. Although 7 additional compliance-enhancing measures had been conceived and planned with the best intentions, they were not realized. These required extra, unpaid time from the orthoptists, which is especially scarce in hospitals in low-SES areas where the

  4. Development and Implementation of an Academic-Community Partnership to Enhance Care among Homeless Persons

    Directory of Open Access Journals (Sweden)

    Sharon B.S. Gatewood, Pharm.D.

    2011-01-01

    Full Text Available An academic-community partnership between a Health Care for the Homeless (HCH clinic and a school of pharmacy was created in 2005 to provide medication education and identify medication related problems. The urban community based HCH clinic in the Richmond, VA area provides primary health care to the homeless, uninsured and underinsured. The center also offers eye care, dental care, mental health and psychiatric care, substance abuse services, case management, laundry and shower facilities, and mail services at no charge to those in need. Pharmacist services are provided in the mental health and medical clinics. A satisfaction survey showed that the providers and staff (n = 13 in the clinic were very satisfied with the integration of pharmacist services. The quality and safety of medication use has improved as a result of the academic-community collaborative. Education and research initiatives have also resulted from the collaborative. This manuscript describes the implementation, outcomes and benefits of the partnership for both the HCH clinic and the school of pharmacy.An academic-community partnership between a Health Care for the Homeless (HCH clinic and a school of pharmacy was created in 2005 to provide medication education and identify medication related problems. The urban community based HCH clinic in the Richmond, VA area provides primary health care to the homeless, uninsured and underinsured. The center also offers eye care, dental care, mental health and psychiatric care, substance abuse services, case management, laundry and shower facilities, and mail services at no charge to those in need. Pharmacist services are provided in the mental health and medical clinics. A satisfaction survey showed that the providers and staff (n = 13 in the clinic were very satisfied with the integration of pharmacist services. The quality and safety of medication use has improved as a result of the academic-community collaborative. Education and

  5. Enhancement of DRPE performance with a novel scheme based on new RAC: Principle, security analysis and FPGA implementation

    Science.gov (United States)

    Neji, N.; Jridi, M.; Alfalou, A.; Masmoudi, N.

    2016-02-01

    The double random phase encryption (DRPE) method is a well-known all-optical architecture which has many advantages especially in terms of encryption efficiency. However, the method presents some vulnerabilities against attacks and requires a large quantity of information to encode the complex output plane. In this paper, we present an innovative hybrid technique to enhance the performance of DRPE method in terms of compression and encryption. An optimized simultaneous compression and encryption method is applied simultaneously on the real and imaginary components of the DRPE output plane. The compression and encryption technique consists in using an innovative randomized arithmetic coder (RAC) that can well compress the DRPE output planes and at the same time enhance the encryption. The RAC is obtained by an appropriate selection of some conditions in the binary arithmetic coding (BAC) process and by using a pseudo-random number to encrypt the corresponding outputs. The proposed technique has the capabilities to process video content and to be standard compliant with modern video coding standards such as H264 and HEVC. Simulations demonstrate that the proposed crypto-compression system has presented the drawbacks of the DRPE method. The cryptographic properties of DRPE have been enhanced while a compression rate of one-sixth can be achieved. FPGA implementation results show the high performance of the proposed method in terms of maximum operating frequency, hardware occupation, and dynamic power consumption.

  6. Development and Implementation of an Academic-Community Partnership to Enhance Care among Homeless Persons

    Directory of Open Access Journals (Sweden)

    Sharon B.S. Gatewood

    2011-01-01

    Full Text Available An academic-community partnership between a Health Care for the Homeless (HCH clinic and a school of pharmacy was created in 2005 to provide medication education and identify medication related problems. The urban community based HCH clinic in the Richmond, VA area provides primary health care to the homeless, uninsured and underinsured. The center also offers eye care, dental care, mental health and psychiatric care, substance abuse services, case management, laundry and shower facilities, and mail services at no charge to those in need. Pharmacist services are provided in the mental health and medical clinics. A satisfaction survey showed that the providers and staff (n = 13 in the clinic were very satisfied with the integration of pharmacist services. The quality and safety of medication use has improved as a result of the academic-community collaborative. Education and research initiatives have also resulted from the collaborative. This manuscript describes the implementation, outcomes and benefits of the partnership for both the HCH clinic and the school of pharmacy. Type: Clinical Experience

  7. How to reduce nephropathy following contrast-enhanced CT: A lesson in policy implementation

    International Nuclear Information System (INIS)

    Richenberg, J.

    2012-01-01

    In excess of 50 contrast-enhanced computed tomography (CT) examinations are typically undertaken in our tertiary hospital NHS Trust each weekday, approximately 13,000 each year. In the Department of Radiology alone, we inject more than 1300 l of iodinated contrast medium per annum. There is a real need to devise a policy to anticipate contrast medium-induced nephropathy (CIN) and minimize its effects, without disrupting the high-intensity CT service. Having written a comprehensive yet pragmatic policy to reduce the incidence of this iatrogenic condition, it seemed sensible to share it with the wider radiology community and share the experience and lessons learnt in engaging all the stakeholders, ushering in the change with as little fuss as possible. The ramifications on primary and secondary care had to be anticipated, resource implications managed, and staff trained. This review is therefore presented in four sections: framing the problem, assessing its size and nature; a succeeding section on the available guidelines and their uptake; the policy itself to reduce CIN in CT is presented in the third section; and crucially, a description of the policy introduction process in the last section.

  8. Technology-enhanced practice for patients with chronic cardiac disease: home implementation and evaluation.

    Science.gov (United States)

    Brennan, Patricia Flatley; Casper, Gail R; Burke, Laura J; Johnson, Kathy A; Brown, Roger; Valdez, Rupa S; Sebern, Marge; Perez, Oscar A; Sturgeon, Billie

    2010-01-01

    This 3-year field experiment engaged 60 nurses and 282 patients in the design and evaluation of an innovative home-care nursing model, referred to as technology-enhanced practice (TEP). Nurses using TEP augmented the usual care with a web-based resource (HeartCareII) that provided patients with self-management information, self-monitoring tools, and messaging services. Patients exposed to TEP demonstrated better quality of life and self-management of chronic heart disease during the first 4 weeks, and were no more likely than patients in usual care to make unplanned visits to a clinician or hospital. Both groups demonstrated the same long-term symptom management and achievements in health status. This project provides new evidence that the purposeful creation of patient-tailored web resources within a hospital portal is possible; that nurses have difficulty with modifying their practice routines, even with a highly-tailored web resource; and that the benefits of this intervention are more discernable in the early postdischarge stages of care. Copyright © 2010 Elsevier Inc. All rights reserved.

  9. A Novel Enhanced Positioning Trilateration Algorithm Implemented for Medical Implant In-Body Localization

    Directory of Open Access Journals (Sweden)

    Peter Brida

    2013-01-01

    Full Text Available Medical implants based on wireless communication will play crucial role in healthcare systems. Some applications need to know the exact position of each implant. RF positioning seems to be an effective approach for implant localization. The two most common positioning data typically used for RF positioning are received signal strength and time of flight of a radio signal between transmitter and receivers (medical implant and network of reference devices with known position. This leads to positioning methods: received signal strength (RSS and time of arrival (ToA. Both methods are based on trilateration. Used positioning data are very important, but the positioning algorithm which estimates the implant position is important as well. In this paper, the proposal of novel algorithm for trilateration is presented. The proposed algorithm improves the quality of basic trilateration algorithms with the same quality of measured positioning data. It is called Enhanced Positioning Trilateration Algorithm (EPTA. The proposed algorithm can be divided into two phases. The first phase is focused on the selection of the most suitable sensors for position estimation. The goal of the second one lies in the positioning accuracy improving by adaptive algorithm. Finally, we provide performance analysis of the proposed algorithm by computer simulations.

  10. Enhancements to the TOUGH2 Simulator as Implemented in iTOUGH2

    Energy Technology Data Exchange (ETDEWEB)

    Finsterle, Stefan [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2015-03-01

    iTOUGH2 is a program for parameter estimation, sensitivity analysis, and uncertainty propagation analysis. It is based on the TOUGH2 simulator for non-isothermal multiphase, multicomponent flow and transport in fractured and porous media [Pruess, 1987, 1991, 2005, 2011; Falta et al., 1995; Pruess et al., 1999, 2002, 2012; Doughty, 2013]. The core of iTOUGH2 contains slightly modified versions of TOUGH2 modules. Most code modifications are editorial and do not affect the simulation results. As a result, standard TOUGH2 input files can be used in iTOUGH2, and identical results are obtained if iTOUGH2 is run in forward mode. However, a number of modifications have been made as described in this report. They enhance the functionality, flexibilitu, and eas-of-use of the forward simulator. This report complements the reports iTOUGH2 User's Guide, iTOUGH2 Command Referecne, and the collection of tutorial examples in iTOUGH2 Sample Problems.

  11. Liver sinusoidal endothelial cells induce immunosuppressive IL-10-producing Th1 cells via the Notch pathway

    NARCIS (Netherlands)

    Neumann, Katrin; Rudolph, Christine; Neumann, Christian; Janke, Marko; Amsen, Derk; Scheffold, Alexander

    2015-01-01

    Under homeostasis, liver sinusoidal endothelial cells (LSECs) shift intrahepatic T-cell responses towards tolerance. However, the role of LSECs in the regulation of T-cell-induced liver inflammation is less clear. Here, we studied the capacity of LSECs to modulate pro-inflammatory Th1-cell

  12. Band structure and optical properties of sinusoidal superlattices: ZnSe1-xTex

    International Nuclear Information System (INIS)

    Yang, G.; Lee, S.; Furdyna, J. K.

    2000-01-01

    This paper examines the band structure and optical selection rules in superlattices with a sinusoidal potential profile. The analysis is motivated by the recent successful fabrication of high quality ZnSe 1-x Te x superlattices in which the composition x varies sinusoidally along the growth direction. Although the band alignment in the ZnSe 1-x Te x sinusoidal superlattices is staggered (type II), they exhibit unexpectedly strong photoluminescence, thus suggesting interesting optical behavior. The band structure of such sinusoidal superlattices is formulated in terms of the nearly-free-electron (NFE) approximation, in which the superlattice potential is treated as a perturbation. The resulting band structure is unique, characterized by a single minigap separating two wide, free-electron-like subbands for both electrons and holes. Interband selection rules are derived for optical transitions involving conduction and valence-band states at the superlattice Brillouin-zone center, and at the zone edge. A number of transitions are predicted due to wave-function mixing of different subband states. It should be noted that the zone-center and zone-edge transitions are especially easy to distinguish in these superlattices because of the large width of the respective subbands. The results of the NFE approximation are shown to hold surprisingly well over a wide range of parameters, particularly when the period of the superlattice is short. (c) 2000 The American Physical Society

  13. A Perceptual Model for Sinusoidal Audio Coding Based on Spectral Integration

    NARCIS (Netherlands)

    Van de Par, S.; Kohlrausch, A.; Heusdens, R.; Jensen, J.; Holdt Jensen, S.

    2005-01-01

    Psychoacoustical models have been used extensively within audio coding applications over the past decades. Recently, parametric coding techniques have been applied to general audio and this has created the need for a psychoacoustical model that is specifically suited for sinusoidal modelling of

  14. A perceptual model for sinusoidal audio coding based on spectral integration

    NARCIS (Netherlands)

    Van de Par, S.; Kohlrauch, A.; Heusdens, R.; Jensen, J.; Jensen, S.H.

    2005-01-01

    Psychoacoustical models have been used extensively within audio coding applications over the past decades. Recently, parametric coding techniques have been applied to general audio and this has created the need for a psychoacoustical model that is specifically suited for sinusoidal modelling of

  15. Comparison between the water activation effects by pulsed and sinusoidal helium plasma jets

    Science.gov (United States)

    Xu, Han; Liu, Dingxin; Xia, Wenjie; Chen, Chen; Wang, Weitao; Liu, Zhijie; Wang, Xiaohua; Kong, Michael G.

    2018-01-01

    Comparisons between pulsed and sinusoidal plasma jets have been extensively reported for the discharge characteristics and gaseous reactive species, but rarely for the aqueous reactive species in water solutions treated by the two types of plasma jets. This motivates us to compare the concentrations of aqueous reactive species induced by a pulsed and a sinusoidal plasma jet, since it is widely reported that these aqueous reactive species play a crucial role in various plasma biomedical applications. Experimental results show that the aqueous H2O2, OH/O2-, and O2-/ONOO- induced by the pulsed plasma jet have higher concentrations, and the proportional difference increases with the discharge power. However, the emission intensities of OH(A) and O(3p5P) are higher for the sinusoidal plasma jet, which may be attributed to its higher gas temperature since more water vapor could participate in the plasma. In addition, the efficiency of bacterial inactivation induced by the pulsed plasma jet is higher than that for the sinusoidal plasma jet, in accordance with the concentration relation of aqueous reactive species for the two types of plasma jets.

  16. Measurement of definite integral of sinusoidal signal absolute value third power using digital stochastic method

    Directory of Open Access Journals (Sweden)

    Beljić Željko

    2017-01-01

    Full Text Available In this paper a special case of digital stochastic measurement of the third power of definite integral of sinusoidal signal’s absolute value, using 2-bit AD converters is presented. This case of digital stochastic method had emerged from the need to measure power and energy of the wind. Power and energy are proportional to the third power of wind speed. Anemometer output signal is sinusoidal. Therefore an integral of the third power of sinusoidal signal is zero. Two approaches are proposed for the third power calculation of the wind speed signal. One approach is to use absolute value of sinusoidal signal (before AD conversion for which there is no need of multiplier hardware change. The second approach requires small multiplier hardware change, but input signal remains unchanged. For the second approach proposed minimal hardware change was made to calculate absolute value of the result after AD conversion. Simulations have confirmed theoretical analysis. Expected precision of wind energy measurement of proposed device is better than 0,00051% of full scale. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. TR32019

  17. A Perceptual Model for Sinusoidal Audio Coding Based on Spectral Integration

    Directory of Open Access Journals (Sweden)

    Jensen Søren Holdt

    2005-01-01

    Full Text Available Psychoacoustical models have been used extensively within audio coding applications over the past decades. Recently, parametric coding techniques have been applied to general audio and this has created the need for a psychoacoustical model that is specifically suited for sinusoidal modelling of audio signals. In this paper, we present a new perceptual model that predicts masked thresholds for sinusoidal distortions. The model relies on signal detection theory and incorporates more recent insights about spectral and temporal integration in auditory masking. As a consequence, the model is able to predict the distortion detectability. In fact, the distortion detectability defines a (perceptually relevant norm on the underlying signal space which is beneficial for optimisation algorithms such as rate-distortion optimisation or linear predictive coding. We evaluate the merits of the model by combining it with a sinusoidal extraction method and compare the results with those obtained with the ISO MPEG-1 Layer I-II recommended model. Listening tests show a clear preference for the new model. More specifically, the model presented here leads to a reduction of more than 20% in terms of number of sinusoids needed to represent signals at a given quality level.

  18. Iron Losses in Electrical Machines Due to Non Sinusoidal Alternating Fluxes

    DEFF Research Database (Denmark)

    Ritchie, Ewen; Walker, J.A.; Dorrell, D. G.

    2007-01-01

    This paper shows how the flux waveform in the core of an electrical machine can be vary non- sinusoidally which complicates the calculation of the iron loss in a machine. A set of tests are conducted on a steel sample using an Epstein square where harmonics are injected into the flux waveform which...... of a machine....

  19. Stress singularities in a model of a wood disk under sinusoidal pressure

    Science.gov (United States)

    Jay A. Johnson; John C. Hermanson; Steven M. Cramer; Charles Amundson

    2005-01-01

    A thin, solid, circular wood disk, cut from the transverse plane of a tree stem, can be modeled as a cylindrically orthotropic elastic material. It is known that a stress singularity can occur at the center of a cylindrically orthotropic disk subjected to uniform pressure. If a solid cylindrically orthotropic disk is subjected to sinusoidal pressure distributions, then...

  20. Enhancing the ED Approach to Pediatric Sexual Assault Care: Implementation of a Pediatric SART Program

    Science.gov (United States)

    Goyal, MK; Mollen, CJ; Hayes, KL; Molnar, J; Christian, CW; Scribano, PV; Lavelle, J

    2013-01-01

    Objective Describe the experience of a novel pediatric Sexual Assault Response Team (SART) program in the first three years of implementation, and compare patient characteristics, evaluation, and treatment among subpopulations of patients. Methods Retrospective chart review of a consecutive sample of patients evaluated at a pediatric ED who met institutional criteria for a SART evaluation. Associations of evaluation and treatment with gender, menarchal status, and presence of injuries were measured using logistic regression. Results One hundred and eighty-four patients met criteria for SART evaluation, of whom 87.5% were female; mean age was 10.1 years (+/− 4.6 years). The majority of patients underwent forensic evidence collection (89.1%), which varied by menarchal status among females (p<0.01), but not by gender. Evidence of acute anogenital injury on physical exam was found in 20.6% of patients. As per the Center for Disease Control and Prevention guidelines for acute sexual assault evaluations in pediatric patients, menarchal females were more likely to undergo testing for sexually transmitted infections (STI) and pregnancy (p<0.01) and to be offered pregnancy, STI, and HIV prophylaxis (p<0.01). Conclusions In an effort to improve quality and consistency of acute sexual assault examinations in a pediatric ED, development of a SART program supported the majority of eligible patients undergoing forensic evidence collection. Furthermore, a substantial number of patients had evidence of injury on exam. These findings underscore the importance of having properly trained personnel to support ED care for pediatric victims of acute sexual assault. PMID:23974714

  1. Implementation of enhanced recovery programme for laparoscopic distal pancreatectomy: feasibility, safety and cost analysis.

    Science.gov (United States)

    Richardson, John; Di Fabio, Francesco; Clarke, Hannah; Bajalan, Mohammed; Davids, Joe; Abu Hilal, Mohammed

    2015-01-01

    The adoption of laparoscopy for distal pancreatectomy has proven to substantially improve short-term outcomes. Stress response after major surgery can be further minimized within an enhanced recovery programme (ERP). However, data on the potential benefit of an ERP for laparoscopic distal pancreatectomy are still lacking. The aim was to assess the feasibility, safety and cost of ERP for patients undergoing laparoscopic distal pancreatectomy. This is a case-control study from a Tertiary University Hospital. Sixty-six consecutive patients who underwent laparoscopic distal pancreatectomy were analyzed. Twenty-two patients were enrolled for the ERP and compared with previous consecutive 44 patients managed traditionally (1:2 ratio). Operative details, post-operative outcome and cost analysis were compared in the two groups. Patients enrolled in the ERP had similar intraoperative blood loss (median 165 ml vs. 200 ml; p = 0.176), operation time (225 min vs. 210 min; p = 0.633), time to remove naso-gastric tube (1 vs. 1 day; p = 0.081) but significantly shorter time to mobilization (median 1 vs. 2 days; p = 0.0001), start solid diet (2 vs. 3 days; p = 0004), and pass stools (3 vs. 5 days; p = 0.002) compared to the control group. Median length of stay was significantly shorter in the ERP group (3 vs. 6 days; p pancreatectomy with significant earlier return to normal gut function, reduced length of stay and cost saving. Copyright © 2015 IAP and EPC. Published by Elsevier B.V. All rights reserved.

  2. Dynamic Characteristics of Ventilatory and Gas Exchange during Sinusoidal Walking in Humans.

    Directory of Open Access Journals (Sweden)

    Yoshiyuki Fukuoka

    Full Text Available Our present study investigated whether the ventilatory and gas exchange responses show different dynamics in response to sinusoidal change in cycle work rate or walking speed even if the metabolic demand was equivalent in both types of exercise. Locomotive parameters (stride length and step frequency, breath-by-breath ventilation (V̇E and gas exchange (CO2 output (V̇CO2 and O2 uptake (V̇O2 responses were measured in 10 healthy young participants. The speed of the treadmill was sinusoidally changed between 3 km·h-1 and 6 km·h-1 with various periods (from 10 to 1 min. The amplitude of locomotive parameters against sinusoidal variation showed a constant gain with a small phase shift, being independent of the oscillation periods. In marked contrast, when the periods of the speed oscillations were shortened, the amplitude of V̇E decreased sharply whereas the phase shift of V̇E increased. In comparing walking and cycling at the equivalent metabolic demand, the amplitude of V̇E during sinusoidal walking (SW was significantly greater than that during sinusoidal cycling (SC, and the phase shift became smaller. The steeper slope of linear regression for the V̇E amplitude ratio to V̇CO2 amplitude ratio was observed during SW than SC. These findings suggested that the greater amplitude and smaller phase shift of ventilatory dynamics were not equivalent between SW and SC even if the metabolic demand was equivalent between both exercises. Such phenomenon would be derived from central command in proportion to locomotor muscle recruitment (feedforward and muscle afferent feedback.

  3. Enhancing outreach for persons with serious mental illness: 12-month results from a cluster randomized trial of an adaptive implementation strategy.

    Science.gov (United States)

    Kilbourne, Amy M; Almirall, Daniel; Goodrich, David E; Lai, Zongshan; Abraham, Kristen M; Nord, Kristina M; Bowersox, Nicholas W

    2014-12-28

    Few implementation strategies have been empirically tested for their effectiveness in improving uptake of evidence-based treatments or programs. This study compared the effectiveness of an immediate versus delayed enhanced implementation strategy (Enhanced Replicating Effective Programs (REP)) for providers at Veterans Health Administration (VA) outpatient facilities (sites) on improved uptake of an outreach program (Re-Engage) among sites not initially responding to a standard implementation strategy. One mental health provider from each U.S. VA site (N = 158) was initially given a REP-based package and training program in Re-Engage. The Re-Engage program involved giving each site provider a list of patients with serious mental illness who had not been seen at their facility for at least a year, requesting that providers contact these patients, assessing patient clinical status, and where appropriate, facilitating appointments to VA health services. At month 6, sites considered non-responsive (N = 89, total of 3,075 patients), defined as providers updating documentation for less than implementation interventions: Enhanced REP (provider coaching; N = 40 sites) for 6 months followed by Standard REP for 6 months; versus continued Standard REP (N = 49 sites) for 6 months followed by 6 months of Enhanced REP for sites still not responding. Outcomes included patient-level Re-Engage implementation and utilization. Patients from sites that were randomized to receive Enhanced REP immediately compared to Standard REP were more likely to have a completed contact (adjusted OR = 2.13; 95% CI: 1.09-4.19, P = 0.02). There were no differences in patient-level utilization between Enhanced and Standard REP sites. Enhanced REP was associated with greater Re-Engage program uptake (completed contacts) among sites not responding to a standard implementation strategy. Further research is needed to determine whether national implementation of Facilitation results

  4. Combining Geoelectrical Measurements and CO2 Analyses to Monitor the Enhanced Bioremediation of Hydrocarbon-Contaminated Soils: A Field Implementation

    Directory of Open Access Journals (Sweden)

    Cécile Noel

    2016-01-01

    Full Text Available Hydrocarbon-contaminated aquifers can be successfully remediated through enhanced biodegradation. However, in situ monitoring of the treatment by piezometers is expensive and invasive and might be insufficient as the information provided is restricted to vertical profiles at discrete locations. An alternative method was tested in order to improve the robustness of the monitoring. Geophysical methods, electrical resistivity (ER and induced polarization (IP, were combined with gas analyses, CO2 concentration, and its carbon isotopic ratio, to develop a less invasive methodology for monitoring enhanced biodegradation of hydrocarbons. The field implementation of this monitoring methodology, which lasted from February 2014 until June 2015, was carried out at a BTEX-polluted site under aerobic biotreatment. Geophysical monitoring shows a more conductive and chargeable area which corresponds to the contaminated zone. In this area, high CO2 emissions have been measured with an isotopic signature demonstrating that the main source of CO2 on this site is the biodegradation of hydrocarbon fuels. Besides, the evolution of geochemical and geophysical data over a year seems to show the seasonal variation of bacterial activity. Combining geophysics with gas analyses is thus promising to provide a new methodology for in situ monitoring.

  5. The two dynamical states in sinusoidal potentials: An analog simulation experiment

    Science.gov (United States)

    Sawkmie, Ivan Skhem; Mahato, Mangal C.

    2018-04-01

    The phenomenon of stochastic resonance (SR) is usually found to occur theoretically as well as experimentally in bi-stable systems [1]. Recently, it was numerically shown that SR is found to occur in underdamped (friction coefficient γ) sinusoidal potentials also. The occurrence of SR is explained in terms of two competing dynamical states of trajectories as a response to the external periodic drive. We setup an analog simulation experiment similar to the analog simulation work done earlier to study stochastic nonlinear dynamics [2], to verify the existence of the two dynamical states and to investigate the occurrence of SR in sinusoidal potentials obtained earlier [3]. We discuss our experimental setup and the results obtained in detail.

  6. Compact broadband polarization beam splitter using a symmetric directional coupler with sinusoidal bends.

    Science.gov (United States)

    Zhang, Fan; Yun, Han; Wang, Yun; Lu, Zeqin; Chrostowski, Lukas; Jaeger, Nicolas A F

    2017-01-15

    We design and demonstrate a compact broadband polarization beam splitter (PBS) using a symmetric directional coupler with sinusoidal bends on a silicon-on-insulator platform. The sinusoidal bends in our PBS suppress the power exchange between two parallel symmetric strip waveguides for the transverse-electric (TE) mode, while allowing for the maximum power transfer to the adjacent waveguide for the transverse-magnetic (TM) mode. Our PBS has a nominal coupler length of 8.55 μm, and it has an average extinction ratio (ER) of 12.0 dB for the TE mode, an average ER of 20.1 dB for the TM mode, an average polarization isolation (PI) of 20.6 dB for the through port, and an average PI of 11.5 dB for the cross port, all over a bandwidth of 100 nm.

  7. Levitation performance of high-T{sub c} superconductor in sinusoidal guideway magnetic field

    Energy Technology Data Exchange (ETDEWEB)

    Liu, W. [Applied Superconductivity Laboratory, Southwest Jiaotong University, Chengdu 610031 (China)], E-mail: asclab@asclab.cn; Wang, J.S.; Jing, H.; Jiang, M.; Zheng, J.; Wang, S.Y. [Applied Superconductivity Laboratory, Southwest Jiaotong University, Chengdu 610031 (China)

    2008-12-01

    The vertical component of the Halbach array's magnetic field exhibits a sinusoid distribution because of the closed magnetic flux area between two neighbouring poles, so this field can be regarded as the sinusoidal magnetic field. This article mainly discusses the influence of the closed flux region on the levitation performance of the bulk high-temperature superconductor (HTS). Moreover, the levitation performance is compared between the closed and diverging region of magnetic flux. The experimental results can be analyzed by the magnetic circuit theory and the frozen-image model. The analysis indicates that the closed region of magnetic flux can influence the levitation performance of bulk HTS obviously and provide an extra useful guidance force. These conclusions are helpful to optimize the HTS Maglev system.

  8. New Results on Single-Channel Speech Separation Using Sinusoidal Modeling

    DEFF Research Database (Denmark)

    Mowlaee, Pejman; Christensen, Mads Græsbøll; Jensen, Søren Holdt

    2011-01-01

    We present new results on single-channel speech separation and suggest a new separation approach to improve the speech quality of separated signals from an observed mix- ture. The key idea is to derive a mixture estimator based on sinusoidal parameters. The proposed estimator is aimed at finding...... mixture estimator used in binary masks and the Wiener filtering approach, it is observed that the proposed method achieves an acceptable perceptual speech quality with less cross- talk at different signal-to-signal ratios. Moreover, the method is independent of pitch estimates and reduces the computational...... complexity of the separation by replacing the short-time Fourier transform (STFT) feature vectors of high dimensionality with sinusoidal feature vectors. We report separation results for the proposed method and compare them with respect to other benchmark methods. The improvements made by applying...

  9. [Defibrotide therapy for patients with sinusoidal obstruction syndrome after hematopoietic stem cell transplantation].

    Science.gov (United States)

    Yakushijin, Kimikazu; Okamura, Atsuo; Ono, Kanako; Kawano, Yuko; Kawano, Hiroki; Funakoshi, Yohei; Kawamori, Yuriko; Nishikawa, Shinichiro; Minagawa, Kentaro; Sada, Akiko; Shimoyama, Manabu; Yamamoto, Katsuya; Katayama, Yoshio; Matsui, Toshimitsu

    2009-01-01

    Sinusoidal obstruction syndrome (SOS) is one of the life-threatening complications caused by endothelial damage to the hepatic sinusoids after hematopoietic stem cell transplantation. However, a satisfactory treatment for SOS has not yet been established. Defibrotide has anti-thrombotic, anti-ischemic, anti-inflammatory, and thrombolytic properties without systemic anticoagulant effects. We treated eight post-transplant SOS patients with defibrotide. Three patients responded to the therapy and the initial response was observed within a week. In addition to the improvement of liver function, rapid recovery of response to diuretic drugs followed by the improvement of renal function was observed. All of the five patients with respiratory dysfunction died despite administration of defibrotide, suggesting that early treatment might lead to better outcomes. There were no severe adverse effects directly due to defibrotide administration. Defibrotide seems to be a promising treatment for SOS, and the initiation of a clinical study in Japan would be important.

  10. Flow and heat transfer characteristics in a channel having furrowed wall based on sinusoidal wave

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Jiansheng; Gao, Xiaoming; Li, Weiyi [Tianjin University, Tianjin (Switzerland)

    2015-11-15

    The effect of wall geometry on the flow and heat transfer in a channel with one lower furrowed and an upper flat wall kept at a uniform temperature is investigated by large eddy simulation. Three channels, one with sinusoidal wavy surface having the ratio (amplitude to wavelength) α/λ=0.05 and the other two with furrowed surface derived from the sinusoidal curve, are considered. The numerical results show that the streamwise vortices center is located near the lower wall and vary along the streamwise on various furrow surfaces. The furrow geometry increases the pressure drag and decreases the friction drag of the furrowed surface compared with that of the smooth surface; consequently, the total drag is increased for the augment of pressure drag. As expected, the heat transfer performance has been improved. Finally, a thermal performance factor is defined to evaluate the performance of the furrowed wall.

  11. [The sequential use of local vacuum magnetotherapy and papaverine electrophoresis with sinusoidal modulated currents in impotence].

    Science.gov (United States)

    Karpukhin, I V; Bogomol'nyĭ, V A

    1997-01-01

    105 patients with chronic nonspecific prostatitis were examined and treated with papaverin electrophoresis using sinusoidal modulated currents (SMC) and local vacuum magnetotherapy (LVMT). Papaverin SMC electrophoresis and LVMT stimulated cavernous circulation. The highest stimulation was achieved at successive use of LVMT and the electrophoresis. LVMT followed by the electrophoresis maintained good cavernous circulation for 5-6 hours after the procedure in the course of which several spontaneous erections were observed.

  12. Facilitators and barriers of implementing enhanced recovery in colorectal surgery at a safety net hospital: A provider and patient perspective.

    Science.gov (United States)

    Alawadi, Zeinab M; Leal, Isabel; Phatak, Uma R; Flores-Gonzalez, Juan R; Holihan, Julie L; Karanjawala, Burzeen E; Millas, Stefanos G; Kao, Lillian S

    2016-03-01

    Enhanced Recovery After Surgery (ERAS) pathways are known to decrease complications and duration of stay in colorectal surgery patients. However, it is unclear whether an ERAS pathway would be feasible and effective at a safety-net hospital. The aim of this study was to identify local barriers and facilitators before the adoption of an ERAS pathway for patients undergoing colorectal operations at a safety-net hospital. Semistructured interviews were conducted to assess the perceived barriers and facilitators before ERAS adoption. Stratified purposive sampling was used. Interviews were audiotaped, transcribed verbatim, and analyzed using content analysis. Analytic and investigator triangulation were used to establish credibility. Interviewees included 8 anesthesiologists, 5 surgeons, 6 nurses, and 18 patients. Facilitators identified across the different medical professions were (1) feasibility and alignment with current practice, (2) standardization of care, (3) smallness of community, (4) good teamwork and communication, and (5) caring for patients. The barriers were (1) difficulty in adapting to change, (2) lack of coordination between different departments, (3) special needs of a highly comorbid and socioeconomically disadvantaged patient population, (4) limited resources, and (5) rotating residents. Facilitators identified by the patients were (1) welcoming a speedy recovery, (2) being well-cared for and satisfied with treatment, (3) adequate social support, (4) welcoming early mobilization, and (5) effective pain management. The barriers were (1) lack of quiet and private space, (2) need for more patient education and counseling, and (3) unforeseen complications. Although limited hospital resources are perceived as a barrier to ERAS implementation at a safety-net hospital, there is strong support for such pathways and multiple factors were identified that may facilitate change. Inclusion of patient perspectives is critical to identifying challenges and

  13. Tunneling time in fluctuating symmetric double wells: Suppression and enhancement of tunneling by spatial symmetry-preserving perturbations

    International Nuclear Information System (INIS)

    Kar, Susmita; Bhattacharyya, S.P.

    2011-01-01

    Graphical abstract: Spatial symmetry-preserving sinusoidal fluctuations of symmetric double-well parameters cause enhancement of tunneling at ω ∼ ω 0 while rectified sinusoidal fluctuations suppress it at ω∼(ω 0 )/2 . Research highlights: → Spatial symmetry-preserving sinusoidal and rectified sinusoidal fluctuations of symmetrical double-well parameters have contrasting effects on tunneling. → Sinusoidal fluctuations at frequency ω ∼ ω 0 causes resonance enhancement of tunneling, ω 0 being the 0 + ↔ 1 + transition frequency. → Under rectified sinusoidal fluctuations at a frequency ω∼1/2 ω 0 suppression or coherent destruction of tunneling is observed due to barrier localization. → The observations are explained by energy-gain analysis and analysis of the time-dependent overlap amplitudes. - Abstract: We investigate how tunneling-time gets affected by spatial symmetry preserving fluctuations in the parameters determining the width, barrier height and well-depth of a symmetric double-well potential. Sinusoidal and rectified sinusoidal fluctuations of the well-parameters are shown to have contrasting effects. Significant enhancement of tunneling is noticed when the well-parameters fluctuate sinusoidally with frequency ω ∼ ω 0 while under rectified sinusoidal perturbation, quenching of tunneling takes place at a fluctuation frequency ω∼1/2 ω 0 ,ω 0 , being the frequency of the lowest transition allowed by the fluctuation induced spatial perturbation of even parity. Time-dependent Hellmann-Feynman theorem is invoked to analyze the energy changes induced by fluctuations. It turns out that the enhancement of tunneling in the sinusoidally fluctuating double well at frequency ω ∼ ω 0 is caused by transition to 1 ± levels under the barrier while in the rectified sinusoidal field at ω∼1/2 ω 0 , a two-photon like process suppresses the tunneling by inducing barrier localization.

  14. Implementation of Hybrid Speech Dereverberation Systems and Proposing Dual Microphone Farsi Database in Order to Evaluating Enhancement Systems

    Directory of Open Access Journals (Sweden)

    Farhad Faghani

    2013-01-01

    Full Text Available In various applications, such as speech recognition and automatic teleconferencing, the recorded speech signals may be corrupted by both noise and reverberation. Reverberation causes a noticeable change in speech intelligibility and quality. In this research, firstly reverberation is described. There are some de-reverberation enhancement algorithms that use only one microphone. They mostly use inverse filtering and spectral subtraction as their sub-systems. On the other hand, there are many multi-microphone speech enhancement systems; Delay-and-sum beam former is the most famous amongst them. Moreover, several efficient approaches have been also reported that use linear prediction (LP residual signal, inverse filtering, and phase error. Despite the improvements and benefits gained by the use of several input microphones, considering the tradeoff between these gains and the complexity and computational cost forced by the use of more microphones, many researchers have focused on dual-microphones systems. So, a review on Microphone array signal processing is explained and then an arrangement for two microphones systems is proposed. As we want to evaluate these algorithms for Farsi speech signals, the problem of speech intelligibility assessment has been explained and a Farsi word list for Diagnostic Rhyme Test (DRT is presented.The structure of presented word list is similar to that of English DRT words. In this research, after a brief study of above-mentioned methods, we propose and implement some hybrid techniques to benefit from the advantages of several methods and achieve significant improvement in output signals. It will be shown that the proposed method performs superior to the state-of-the-art dereverberation algorithms.

  15. Core losses of a permanent magnet synchronous motor with an amorphous stator core under inverter and sinusoidal excitations

    Science.gov (United States)

    Yao, Atsushi; Sugimoto, Takaya; Odawara, Shunya; Fujisaki, Keisuke

    2018-05-01

    We report core loss properties of permanent magnet synchronous motors (PMSM) with amorphous magnetic materials (AMM) core under inverter and sinusoidal excitations. To discuss the core loss properties of AMM core, a comparison with non-oriented (NO) core is also performed. In addition, based on both experiments and numerical simulations, we estimate higher (time and space) harmonic components of the core losses under inverter and sinusoidal excitations. The core losses of PMSM are reduced by about 59% using AMM stator core instead of NO core under sinusoidal excitation. We show that the average decrease obtained by using AMM instead of NO in the stator core is about 94% in time harmonic components.

  16. Intravascular Immune Surveillance by CXCR6+ NKT Cells Patrolling Liver Sinusoids

    Directory of Open Access Journals (Sweden)

    Geissmann Frederic

    2005-01-01

    Full Text Available We examined the in vivo behavior of liver natural killer T cells (NKT cells by intravital fluorescence microscopic imaging of mice in which a green fluorescent protein cDNA was used to replace the gene encoding the chemokine receptor CXCR6. NKT cells, which account for most CXCR6+ cells in liver, were found to crawl within hepatic sinusoids at 10-20 µm/min and to stop upon T cell antigen receptor activation. CXCR6-deficient mice exhibited a selective and severe reduction of CD1d-reactive NKT cells in the liver and decreased susceptibility to T-cell-dependent hepatitis. CXCL16, the cell surface ligand for CXCR6, is expressed on sinusoidal endothelial cells, and CXCR6 deficiency resulted in reduced survival, but not in altered speed or pattern of patrolling of NKT cells. Thus, NKT cells patrol liver sinusoids to provide intravascular immune surveillance, and CXCR6 contributes to liver-based immune responses by regulating their abundance.

  17. Sinusoidal obstruction syndrome (SOS): A light and electron microscopy study in human liver.

    Science.gov (United States)

    Vreuls, C P H; Driessen, A; Olde Damink, S W M; Koek, G H; Duimel, H; van den Broek, M A J; Dejong, C H C; Braet, F; Wisse, E

    2016-05-01

    Oxaliplatin is an important chemotherapeutic agent, used in the treatment of hepatic colorectal metastases, and known to induce the sinusoidal obstruction syndrome (SOS). Pathophysiological knowledge concerning SOS is based on a rat model. Therefore, the aim was to perform a comprehensive study of the features of human SOS, using both light microscopy (LM) and electron microscopy (EM). Included were all patients of whom wedge liver biopsies were collected during a partial hepatectomy for colorectal liver metastases, in a 4-year period. The wedge biopsy were perfusion fixated and processed for LM and EM. The SOS lesions were selected by LM and details were studied using EM. Material was available of 30 patients, of whom 28 patients received neo-adjuvant oxaliplatin. Eighteen (64%) of the 28 patients showed SOS lesions, based on microscopy. The lesions consisted of sinusoidal endothelial cell detachment from the space of Disse on EM. In the enlarged space of Disse a variable amount of erythrocytes were located. Sinusoidal endothelial cell detachment was present in human SOS, accompanied by enlargement of the space of Disse and erythrocytes in this area. These findings, originally described in a rat model, were now for the first time confirmed in human livers under clinically relevant settings. Copyright © 2016 Elsevier Ltd. All rights reserved.

  18. Evaluation of Steel Shear Walls Behavior with Sinusoidal and Trapezoidal Corrugated Plates

    Directory of Open Access Journals (Sweden)

    Emad Hosseinpour

    2015-01-01

    Full Text Available Reinforcement of structures aims to control the input energy of unnatural and natural forces. In the past four decades, steel shear walls are utilized in huge constructions in some seismic countries such as Japan, United States, and Canada to lessen the risk of destructive forces. The steel shear walls are divided into two types: unstiffened and stiffened. In the former, a series of plates (sinusoidal and trapezoidal corrugated with light thickness are used that have the postbuckling field property under overall buckling. In the latter, steel profile belt series are employed as stiffeners with different arrangement: horizontal, vertical, or diagonal in one side or both sides of wall. In the unstiffened walls, increasing the thickness causes an increase in the wall capacity under large forces in tall structures. In the stiffened walls, joining the stiffeners to the wall is costly and time consuming. The ANSYS software was used to analyze the different models of unstiffened one-story steel walls with sinusoidal and trapezoidal corrugated plates under lateral load. The obtained results demonstrated that, in the walls with the same dimensions, the trapezoidal corrugated plates showed higher ductility and ultimate bearing compared to the sinusoidal corrugated plates.

  19. Cultivation and Implementation of Community-Engaged Pharmacy Services in a Free Clinic to Enhance Care for the Medically Underserved

    Directory of Open Access Journals (Sweden)

    Emmeline Tran, Pharm.D. Candidate

    2013-01-01

    Full Text Available Partnerships between community free clinics and academic medical centers improve patient outcomes and enhance learning opportunities for students. A community-academic partnership between the Maliheh Free Clinic and the University of Utah College of Pharmacy was formed to fulfill a community need for pharmacy services, to promote interdisciplinary patient care, and to provide an experiential opportunity for students. The Maliheh Free Clinic based in Salt Lake City, Utah provides free primary health care to uninsured individuals who live 150% below federal poverty guidelines. Three pharmacy services were developed and implemented. These include: 1 clinic chart reviews which involve written recommendations following a comprehensive assessment of the patient’s chart examining his or her disease states and the appropriateness of his or her medications; 2 medication reconciliations and discussion of pharmacy-related recommendations with patients during Diabetes Day, an inclusive interdisciplinary patient appointment that addresses important aspects of diabetes care; and 3 an insulin dose adjustment service through a collaborative practice agreement with the clinic to monitor a patient’s blood glucose levels and adjust his or her medications accordingly on a weekly basis.

  20. Protocol: Adaptive Implementation of Effective Programs Trial (ADEPT): cluster randomized SMART trial comparing a standard versus enhanced implementation strategy to improve outcomes of a mood disorders program.

    Science.gov (United States)

    Kilbourne, Amy M; Almirall, Daniel; Eisenberg, Daniel; Waxmonsky, Jeanette; Goodrich, David E; Fortney, John C; Kirchner, JoAnn E; Solberg, Leif I; Main, Deborah; Bauer, Mark S; Kyle, Julia; Murphy, Susan A; Nord, Kristina M; Thomas, Marshall R

    2014-09-30

    Despite the availability of psychosocial evidence-based practices (EBPs), treatment and outcomes for persons with mental disorders remain suboptimal. Replicating Effective Programs (REP), an effective implementation strategy, still resulted in less than half of sites using an EBP. The primary aim of this cluster randomized trial is to determine, among sites not initially responding to REP, the effect of adaptive implementation strategies that begin with an External Facilitator (EF) or with an External Facilitator plus an Internal Facilitator (IF) on improved EBP use and patient outcomes in 12 months. This study employs a sequential multiple assignment randomized trial (SMART) design to build an adaptive implementation strategy. The EBP to be implemented is life goals (LG) for patients with mood disorders across 80 community-based outpatient clinics (N = 1,600 patients) from different U.S. regions. Sites not initially responding to REP (defined as implementation costs, and organizational change. This study design will determine whether an off-site EF alone versus the addition of an on-site IF improves EBP uptake and patient outcomes among sites that do not respond initially to REP. It will also examine the value of delaying the provision of EF/IF for sites that continue to not respond despite EF. ClinicalTrials.gov identifier: NCT02151331.

  1. THE LINGUISTICS OF SPEECH PRINCIPLES TO BE IMPLEMENTED IN THE LISTENING COMPREHENSION CLASS TO ENHANCE LEARNERS‟ SPEAKING SKILLS

    Directory of Open Access Journals (Sweden)

    Oktavia Tri Sanggala Dewi

    2017-04-01

    Full Text Available Linguistics of Speech as linguistic science is about language in use, and the only way to get data is through observations of how language works in real language contexts, and in which the focus is on meaning rather than structure (Kretszmar, W.A.Jr. 2009: 11. The emphasis in meaning is also currently implemented in the implementation of SFL–GBA (Systematic Funtional Linguistic - Genre Based Approach in Indonesia, in which the use of translation is encouraged (to a certain extend to improve understanding (Emilia,E.2011: 34, 41 }. In English classes of Listening Comprehension in Indonesia, as it is found anywhere else in non-English speaking countries, the emphasis is on meaning, i.e enabling students to understand language spoken by native speakers using both standard and spoken English in and about unlimited number ofcontexts and topics.As stated in the title, the goal of this research is to find out whether the basic concept and nature of ―Language‖, which is ―Language is Speech‖, could be materialized through implementing the principles of the Linguistics of Speech, the most important principle of which is the fact that this study concentrates on the ―speech circuit‖, which includes the oral implementation of articulatory, perceptual, physiological, and cognitive ―internal‖ aspects, with reference to ―external‖ considerations like geography, ethnology, policies, and institutions (Kretchmar 2009:62. Related to this, concerning Englishlearning context in Indonesia, the elements affecting learners seriously would be the perceptual andcognitive aspects, as these two have been paved by the policy of the Indonesian government which established Bahasa Indonesia as the first/ national language to be spoken anywhere and any time by Indonesians, and English as the formal second language. Thus the ―Indonesian grammar‖ way of thinking has quite an impact on thesetwo mental activities (perceptual and cognitive in learning and

  2. Mesenchymal stem cell-conditioned medium prevents radiation-induced liver injury by inhibiting inflammation and protecting sinusoidal endothelial cells

    International Nuclear Information System (INIS)

    Chen Yixing; Zeng Zhaochong; Sun Jing; Huang Yan; Zhang Zhenyu; Zeng Haiying

    2015-01-01

    Current management of radiation-induced liver injury is limited. Sinusoidal endothelial cell (SEC) apoptosis and inflammation are considered to be initiating events in hepatic damage. We hypothesized that mesenchymal stem cells (MSCs) possess anti-apoptotic and anti-inflammatory actions during hepatic irradiation, acting via paracrine mechanisms. This study aims to examine whether MSC-derived bioactive components are protective against radiation-induced liver injury in rats. MSC-conditioned medium (MSC-CM) was generated from rat bone marrow–derived MSCs. The effect of MSC-CM on the viability of irradiated SECs was examined by flow cytometric analysis. Activation of the Akt and ERK pathways was analyzed by western blot. MSC-CM was also delivered to Sprague–Dawley rats immediately before receiving liver irradiation, followed by testing for pathological features, changes in serum hyaluronic acid, ALT, and inflammatory cytokine levels, and liver cell apoptosis. MSC-CM enhanced the viability of irradiated SECs in vitro and induced Akt and ERK phosphorylation in these cells. Infusion of MSC-CM immediately before liver irradiation provided a significant anti-apoptotic effect on SECs and improved the histopathological features of injury in the irradiated liver. MSC-CM also reduced the secretion and expression of inflammatory cytokines and increased the expression of anti-inflammatory cytokines. MSC-derived bioactive components could be a novel therapeutic approach for treating radiation-induced liver injury. (author)

  3. Improvement of the growth and yield of lettuce plants by elf sinusoidal non-uniform magnetic fields

    International Nuclear Information System (INIS)

    Souzal, A. De; Gonzalez, L.M.; Sueirol, L.; Peralta, O.; Liceal, L.; Porras, E.; Gilart, F.

    2008-01-01

    Influence of pre-sowing magnetic treatments on plant growth and final yield of lettuce (cv. Black Seeded Simpson) were studied under organoponic conditions. Lettuce seeds were exposed to full-wave rectified sinusoidal non-uniform magnetic fields (MFs) induced by an electromagnet at 120 mT(rms) for 3 min, 160 mT(rms) for 1 min and to 160 mT (rms) for 5 min. Non-treated seeds were considered as controls. Plants were grown in experimental stonemasons (25.2 m2) of an organoponic and cultivated according to standard agricultural practices. During nursery and vegetative growth stages, samples were collected at regular intervals for seedling growth assessment and growth rate analyses. At physiological maturity, the plants were harvested from each stonemason and the final yield and yield parameters were determined. In the nursery stage, the magnetic treatments induced a significant increase of root length and shoot height in plants derived from magnetically-treated seeds. In the vegetative stage, the relative growth rates of plants derived from magnetically-exposed seeds were greater than those shown by the control plants. At maturity stage, all magnetic treatments increased significantly (p<0.05) the plant height, the leaf area per plant, the final yield per area and the fresh mass per plant in comparison with the controls. Pre-sowing magnetic treatments would enhance the growth and final yield of lettuce crop

  4. Development of a Curriculum Management Process by Applying Lean Concept for Waste Elimination to Enhance Curriculum Implementation of Primary School Teacher

    Science.gov (United States)

    Chitrangsan, Nadrudee; Sawekngam, Wichai; Thongthew, Sumlee

    2015-01-01

    This research aims to study and develop a curriculum management process by applying Lean concept for waste elimination to enhance curriculum implementation of primary school teacher. This study was conducted with a focus on qualitative data collection by dividing into 2 phases, including (1) analyze and synthesize relevant notions, theories,…

  5. Gradient Enhanced Physically Based Plasticity: Implementation and Application to a Problem Pertaining Size Effect : Implementation and application to a problem pertaining size effect

    NARCIS (Netherlands)

    Perdahcioglu, Emin Semih; Soyarslan, C.; van den Boogaard, Antonius H.; Bargmann, S.

    2016-01-01

    A physically based plasticity model is implemented which describes work hardening of a material as a function of the total dislocation density. The local part of the model, which involves statistically stored dislocations (SSDs) only, is based on Bergström's original model. The nonlocal part is

  6. Development and Implementation of a Workshop to Enhance the Effectiveness of Mentors Working with Diverse Mentees in HIV Research

    Science.gov (United States)

    Fernandez, Alicia; Stoff, David M.; Narahari, Swathi; Blank, Michael; Fuchs, Jonathan; Evans, Clyde H.; Kahn, James S.; Johnson, Mallory O.

    2014-01-01

    Abstract A growing body of evidence highlights the importance of competent mentoring in academic research in the field of HIV, particularly for early stage investigators from diverse, underrepresented backgrounds. We describe the development and implementation of a 2-day intensive workshop to train mid-level and senior-level investigators conducting HIV-related clinical and translational research across multiple academic institutions on more effective mentoring, with an emphasis on techniques to foster mentees of diversity. The workshop was focused on training mentors in techniques designed to improve the effectiveness of the mentor–mentee relationship, and included didactic presentations, interactive discussions, and small-group problem-based learning activities. Mid-level or senior-level faculty involved or planning to be involved in significant mentorship activities related to HIV research were eligible. Surveys and formal actions plans allowed for workshop evaluation and laid the groundwork for subsequent workshops. Twenty-six faculty from 16 U.S.-based institutions participated, with good representation across discipline, gender, and race/ethnicity. The sessions were highly rated and discussions and evaluations revealed important barriers and facilitators to mentoring, challenges and solutions related to mentoring mentees from diverse backgrounds, and specific tools to enhance mentoring effectiveness. The Mentoring the Mentors training program for HIV researchers focusing on early career investigators of diversity was the first of its kind and was well attended, was rated highly, and provided guidance for improving the program in the future. This training program fills an important gap in the HIV researcher community and offers guidance for training mentors interested in diversity issues in settings outside of HIV. PMID:24735004

  7. Unique cell type-specific junctional complexes in vascular endothelium of human and rat liver sinusoids.

    Directory of Open Access Journals (Sweden)

    Cyrill Géraud

    Full Text Available Liver sinusoidal endothelium is strategically positioned to control access of fluids, macromolecules and cells to the liver parenchyma and to serve clearance functions upstream of the hepatocytes. While clearance of macromolecular debris from the peripheral blood is performed by liver sinusoidal endothelial cells (LSECs using a delicate endocytic receptor system featuring stabilin-1 and -2, the mannose receptor and CD32b, vascular permeability and cell trafficking are controlled by transcellular pores, i.e. the fenestrae, and by intercellular junctional complexes. In contrast to blood vascular and lymphatic endothelial cells in other organs, the junctional complexes of LSECs have not yet been consistently characterized in molecular terms. In a comprehensive analysis, we here show that LSECs express the typical proteins found in endothelial adherens junctions (AJ, i.e. VE-cadherin as well as α-, β-, p120-catenin and plakoglobin. Tight junction (TJ transmembrane proteins typical of endothelial cells, i.e. claudin-5 and occludin, were not expressed by rat LSECs while heterogenous immunreactivity for claudin-5 was detected in human LSECs. In contrast, junctional molecules preferentially associating with TJ such as JAM-A, B and C and zonula occludens proteins ZO-1 and ZO-2 were readily detected in LSECs. Remarkably, among the JAMs JAM-C was considerably over-expressed in LSECs as compared to lung microvascular endothelial cells. In conclusion, we show here that LSECs form a special kind of mixed-type intercellular junctions characterized by co-occurrence of endothelial AJ proteins, and of ZO-1 and -2, and JAMs. The distinct molecular architecture of the intercellular junctional complexes of LSECs corroborates previous ultrastructural findings and provides the molecular basis for further analyses of the endothelial barrier function of liver sinusoids under pathologic conditions ranging from hepatic inflammation to formation of liver metastasis.

  8. Iodine-frequency-stabilized laser diode and displacement-measuring interferometer based on sinusoidal phase modulation

    Science.gov (United States)

    Duong, Quang Anh; Vu, Thanh Tung; Higuchi, Masato; Wei, Dong; Aketagawa, Masato

    2018-06-01

    We propose a sinusoidal phase modulation method to achieve both the frequency stabilization of an external-cavity laser diode (ECLD) to an 127I2 saturated absorption transition near 633 nm and displacement measurement using a Mach–Zehnder interferometer. First, the frequency of the ECLD is stabilized to the b 21 hyperfine component of the P(33) 6-3 transition of 127I2 by combining sinusoidal phase modulation by an electro-optic modulator and frequency modulation spectroscopy by chopping the pump beam using an acousto-optic modulator. Even though a small modulation index of m  =  3.768 rad is utilized, a relative frequency stability of 10‑11 order is obtained over a sampling time of 400 s. Secondly, the frequency-stabilized ECLD is applied as a light source to a Mach–Zehnder interferometer. From the two consecutive modulation harmonics (second and third orders) involved in the interferometer signal, the displacement of the moving mirror is determined for four optical path differences (L 0  =  100, 200, 500, and 1000 mm). The measured modulation indexes for the four optical path differences coincide with the designated value (3.768 rad) within 0.5%. Compared with the sinusoidal frequency modulation Michelson interferometer (Vu et al 2016 Meas. Sci. Technol. 27 105201) which was demonstrated by some of the same authors of this paper, the phase modulation Mach–Zhender interferometer could fix the modulation index to a constant value for the four optical path differences. In this report, we discuss the measurement principle, experimental system, and results.

  9. THE RESONANT OVERVOLTAGE IN NON-SINUSOIDAL MODE OF MAIN ELECTRIC NETWORK

    Directory of Open Access Journals (Sweden)

    V. G. Kuznetsov

    2018-04-01

    Full Text Available Purpose. The resonant overvoltage arises in main electrical networks as a result of random coincidence of some parameters of circuit and its mode and it may exist for a relatively long time. Therefore, the traditional means of limitation of short duration commutation surges are not effective in this case. The study determines conditions of appearance and development of non-sinusoidal mode after switching idle autotransformer to the overhead line of extra high voltage. The purpose of the paper is to choice measures for prevention overvoltage, too. Methodology. The study has used the result of extra high voltage line testing, the methods of electric circuit theory and the simulation in the MATLAB & Simulink package. Results. The simulation model of the extra high voltage transmission line for the study of resonant non-sinusoidal overvoltage is developed. The conditions for the appearance of resonant circuits in the real power line are found and harmonic frequency in which overvoltage arises are obtained. The study proposes using the controlled switching device as a measure to prevent resonance surges and determines the appropriate settings. Originality. The expression for calculation of resonant length of extra high voltage line was derived. The special investigation of processes in the resonant circuit of the extra high voltage transmission line for higher harmonic components of voltage is carried out. The program of switching for control apparatus that prevents non-sinusoidal overvoltage has been developed at the first time. Practical value. The using of the proposed settings of controlled switchgear will prevent the occurrence of hazardous resonant surge on higher harmonic components of voltage.

  10. Impact Testing and Simulation of a Sinusoid Foam Sandwich Energy Absorber

    Science.gov (United States)

    Jackson, Karen E.; Fasanella, Edwin L; Littell, Justin D.

    2015-01-01

    A sinusoidal-shaped foam sandwich energy absorber was developed and evaluated at NASA Langley Research Center through multi-level testing and simulation performed under the Transport Rotorcraft Airframe Crash Testbed (TRACT) research project. The energy absorber, designated the "sinusoid," consisted of hybrid carbon- Kevlar® plain weave fabric face sheets, two layers for each face sheet oriented at +/-45deg with respect to the vertical or crush direction, and a closed-cell ELFOAM(TradeMark) P200 polyisocyanurate (2.0-lb/ft3) foam core. The design goal for the energy absorber was to achieve an average floor-level acceleration of between 25- and 40-g during the full-scale crash test of a retrofitted CH-46E helicopter airframe, designated TRACT 2. Variations in the design were assessed through quasi-static and dynamic crush testing of component specimens. Once the design was finalized, a 5-ft-long subfloor beam was fabricated and retrofitted into a barrel section of a CH-46E helicopter. A vertical drop test of the barrel section was conducted onto concrete to evaluate the performance of the energy absorber prior to retrofit into TRACT 2. Finite element models were developed of all test articles and simulations were performed using LSDYNA ®, a commercial nonlinear explicit transient dynamic finite element code. Test analysis results are presented for the sinusoid foam sandwich energy absorber as comparisons of load-displacement and acceleration-time-history responses, as well as predicted and experimental structural deformations and progressive damage for each evaluation level (component testing through barrel section drop testing).

  11. A Statistical and Spectral Model for Representing Noisy Sounds with Short-Time Sinusoids

    Directory of Open Access Journals (Sweden)

    Myriam Desainte-Catherine

    2005-07-01

    Full Text Available We propose an original model for noise analysis, transformation, and synthesis: the CNSS model. Noisy sounds are represented with short-time sinusoids whose frequencies and phases are random variables. This spectral and statistical model represents information about the spectral density of frequencies. This perceptually relevant property is modeled by three mathematical parameters that define the distribution of the frequencies. This model also represents the spectral envelope. The mathematical parameters are defined and the analysis algorithms to extract these parameters from sounds are introduced. Then algorithms for generating sounds from the parameters of the model are presented. Applications of this model include tools for composers, psychoacoustic experiments, and pedagogy.

  12. Simply Adjustable Sinusoidal Oscillator Based on Negative Three-Port Current Conveyors

    Directory of Open Access Journals (Sweden)

    R. Sotner

    2010-09-01

    Full Text Available The paper deals with sinusoidal oscillator employing two controlled second-generation negative-current conveyors and two capacitors. The proposed oscillator has a simple circuit configuration. Electronic (voltage adjusting of the oscillation frequency and condition of oscillation are possible. The presented circuit is verified in PSpice utilizing macro models of commercially available negative current conveyors. The circuit is also verified by experimental measurements. Important characteristics and drawbacks of the proposed circuit and influences of real active elements in the designed circuit are discussed in detail.

  13. Bottomside sinusoidal irregularities in the equatorial F region. II - Cross-correlation and spectral analysis

    Science.gov (United States)

    Cragin, B. L.; Hanson, W. B.; Mcclure, J. P.; Valladares, C. E.

    1985-01-01

    Equatorial bottomside sinusoidal (BSS) irregularities have been studied by applying techniques of cross-correlation and spectral analysis to the Atmosphere Explorer data set. The phase of the cross-correlations of the plasma number density is discussed and the two drift velocity components observed using the retarding potential analyzer and ion drift meter on the satellite are discussed. Morphology is addressed, presenting the geographical distributions of the occurrence of BSS events for the equinoxes and solstices. Physical processes including the ion Larmor flux, interhemispheric plasma flows, and variations in the lower F region Pedersen conductivity are invoked to explain the findings.

  14. Scintillations associated with bottomside sinusoidal irregularities in the equatorial F region

    Science.gov (United States)

    Basu, S.; Basu, S.; Valladares, C. E.; Dasgupta, A.; Whitney, H. E.

    1986-01-01

    Multisatellite scintillation observations and spaced receiver drift measurements are presented for a category of equatorial F region plasma irregularities characterized by nearly sinusoidal waveforms in the ion number density. The observations were made at Huancayo, Peru, and the measurements at Ancon, Peru, associated with irregularities observed by the Atmospheric-Explorer-E satellite on a few nights in December 1979. Utilizing ray paths to various geostationary satellites, it was found that the irregularities grow and decay almost simultaneously in long-lived patches extending at least 1000 km in the east-west direction.

  15. Sinusoidal Obstruction Syndrome During Chemotherapy of Pediatric Cancers and its Successful Management With Defibrotide.

    Science.gov (United States)

    Kizilocak, Hande; Dikme, Gürcan; Özdemir, Nihal; Kuruğoğlu, Sebuh; Adaletli, İbrahim; Erkan, Tülay; Celkan, Tiraje

    2017-10-01

    Sinusoidal obstruction syndrome (SOS) is a life-threatening complication generally occurring after hematopoietic stem cell transplantation. SOS after standard dose chemotherapy in malignancies is rare. Between the year 1995 and 2016, 414 patients were diagnosed with acute lymphoblastic leukemia and 113 patients were diagnosed with Wilms tumor in our institution. Among these patients, 4 patients with acute lymphoblastic leukemia (0.96%) and 2 patients with Wilms tumor (1.7%) developed SOS during treatment. SOS behaves like a local disseminated intravascular coagulation. Defibrotide has proved to be effective in SOS. In this article, we report our experience with defibrotide in SOS.

  16. Exact solution of unsteady flow generated by sinusoidal pressure gradient in a capillary tube

    Directory of Open Access Journals (Sweden)

    M. Abdulhameed

    2015-12-01

    Full Text Available In this paper, the mathematical modeling of unsteady second grade fluid in a capillary tube with sinusoidal pressure gradient is developed with non-homogenous boundary conditions. Exact analytical solutions for the velocity profiles have been obtained in explicit forms. These solutions are written as the sum of the steady and transient solutions for small and large times. For growing times, the starting solution reduces to the well-known periodic solution that coincides with the corresponding solution of a Newtonian fluid. Graphs representing the solutions are discussed.

  17. Electromagnetic characterization of current transformer with toroidal core under sinusoidal conditions

    Energy Technology Data Exchange (ETDEWEB)

    Koprivica, Branko, E-mail: branko.koprivica@ftn.kg.ac.rs; Milovanovic, Alenka, E-mail: alenka.milovanovic@ftn.kg.ac.rs

    2016-04-01

    The aim of this paper is to present a new procedure for the electromagnetic analysis of a measuring current transformer under sinusoidal conditions in its electrical and magnetic circuit. The influence of the magnetic hysteresis has been taken into account using the measured inverse magnetization curve and phase lag between the time waveforms of the magnetic field and the magnetic induction. Using the proposed analysis, ratio and phase errors of the current transformer have been calculated. The results of the calculation have been compared with experimental results and a good agreement has been found.

  18. Sinusoidal excitation on the Chua's circuit simulation of limit cycles and chaos

    DEFF Research Database (Denmark)

    Lindberg, Erik

    1994-01-01

    of charging”, and stable limit cycle behaviour based on the balance between the energy lost in the regions with mainly positive losses and the energy gained in the regions with mainly negative losses. Convergence problems observed in connection with simulation of the ideal piecewise-linear model are solved......Experiments with modelling and simulation of sinusoidal excitation on Chua's circuit are presented. It is demonstrated that the behaviour of the circuit is based on the interaction of two different kinds of energy balance: chaotic behaviour based on a balance between two unstable “states...

  19. Voltage-Mode Four-Phase Sinusoidal Generator and Its Useful Extensions

    Directory of Open Access Journals (Sweden)

    Sudhanshu Maheshwari

    2013-01-01

    Full Text Available This paper introduces a new voltage-mode second-order sinusoidal generator circuit with four active elements and six passive elements, including grounded capacitors. The frequency and condition of oscillation can be independently controlled. The effect of active element’s nonidealities and parasitic effects is also studied; the proposed topology is good in absorbing several parasitic elements involved with the active elements. The circuit is advantageous for generating high frequency signals which is demonstrated for 25 MHz outputs. Several circuit extensions are also given which makes the new proposal useful for real circuit adoption. The proposed theory is validated through simulation results.

  20. Activities of the Oil Implementation Task Force, December 1990--February 1991; Contracts for field projects and supporting research on enhanced oil recovery, April--June 1990

    Energy Technology Data Exchange (ETDEWEB)

    Tiedemann, H.A. (ed.) (USDOE Bartlesville Project Office, OK (USA))

    1991-03-01

    The Oil Implementation Task Force was appointed to implement the US DOE's new oil research program directed toward increasing domestic oil production by expanded research on near- or mid-term enhanced oil recovery methods. An added priority is to preserve access to reservoirs that have the largest potential for oil recovery, but that are threatened by the large number of wells abandoned each year. This report describes the progress of research activities in the following areas: chemical flooding; gas displacement; thermal recovery; resource assessment; microbial technology; geoscience technology; and environmental technology. (CK)

  1. Implementation of Enhanced Integrated Retail Module (IRM) Installation at Ft. Jackson Clothing Initial Issue Point (CIIP), South Carolina

    National Research Council Canada - National Science Library

    Perrin, Richard A; Fraser, Carol; DeLoach, Doug

    2006-01-01

    ... military clothing inventory. The Enhanced IRM solution brought improvements to accountability of warehouse inventory transactions in VIM/Wholesale Local, improved the efficiency and accountability of sales...

  2. Scavenger receptor-mediated endocytosis by sinusoidal cells in rat bone marrow

    International Nuclear Information System (INIS)

    Geoffroy, J.S.

    1987-01-01

    Endocytosis of serum albumin by sinusoidal endothelial cells in rat bone marrow was investigated initially at the ultrastructural level with subsequent biochemical investigation of the specificity mediating this event. Bovine serum albumin adsorbed to 20nm colloidal gold particles (AuBSA) was chosen as the electron microscopic probe. Morphological data strongly suggested that a receptor was involved in uptake of AuBSA. Confirmation of receptor involvement in the uptake of AuBSA by marrow sinusoidal endothelial cells was achieved utilizing an in situ isolated hind limb perfusion protocol in conjunction with unlabeled, radiolabeled, and radio-/colloidal gold labeled probes. The major findings of competition and saturation experiments were: (1) endocytosis of AuBSA was mediated by a receptor for modified/treated serum albumin; (2) endocytosis of formaldehyde-treated serum albumin was mediated by a binding site which may be the same or closely related to the site responsible for the uptake of AuBSA; and (3) endocytosis of native untreated albumin was not mediated by receptor and probably represents fluid-phase pinocitosis

  3. Biliary obstruction dissipates bioelectric sinusoidal-canalicular barrier without altering taurocholate uptake

    International Nuclear Information System (INIS)

    Cotting, J.; Zysset, T.; Reichen, J.

    1989-01-01

    To study immediate events during extrahepatic cholestasis, we investigated the effect of short-term biliary obstruction on the bioelectrical sinusoidal-canalicular barrier in the rat using molecular weight-matched uncharged and negatively charged inert solute pairs. The bioelectrical barrier averaged -22 +/- 5 and -18 +/- 4 mV (NS) using the pair carboxy-/methoxyinulin and ferrocyanide/sucrose, respectively. After a 20-min biliary obstruction both decreased by 61 and 11%, respectively, but only the large molecular weight pair (the inulins) returned to base line after release of the obstruction. Inert solute clearances were increased after short biliary obstruction depending on molecular size and negative charge (ferrocyanide greater than sucrose greater than carboxyinulin greater than inulin), suggesting that both permeability and bioelectrical barriers were affected by obstruction. The hepatic extraction in vivo of a passively transported drug not excreted into bile (D-propranolol) was not affected by obstruction, whereas that of an actively transported drug (glycocholate) decreased from 66 +/- 8 to 41 +/- 20% during biliary obstruction (P less than 0.01). Unidirectional transfer of glycocholate was not affected by short-term biliary obstruction in the situ perfused rat liver; however, 2 min after [14C]glycocholate administration, increased return was observed in hepatic venous effluent in obstructed animals. Our findings demonstrate a loss of the bioelectrical barrier immediately after short-term biliary obstruction. Decreased hepatic extraction in the view of unaltered sinusoidal uptake demonstrates regurgitation of bile into blood during short-term biliary obstruction

  4. "Artificial micro organs"--a microfluidic device for dielectrophoretic assembly of liver sinusoids.

    Science.gov (United States)

    Schütte, Julia; Hagmeyer, Britta; Holzner, Felix; Kubon, Massimo; Werner, Simon; Freudigmann, Christian; Benz, Karin; Böttger, Jan; Gebhardt, Rolf; Becker, Holger; Stelzle, Martin

    2011-06-01

    In order to study possible toxic side effects of potential drug compounds in vitro a reliable test system is needed. Predicting liver toxicity presents a major challenge of particular importance as liver cells grown in a cell culture suffer from a rapid loss of their liver specific functions. Therefore we are developing a new microfluidic test system for liver toxicity. This test system is based on an organ-like liver 3D co-culture of hepatocytes and endothelial cells. We devised a microfluidic chip featuring cell culture chambers with integrated electrodes for the assembly of liver sinusoids by dielectrophoresis. Fluid channels enable an organ-like perfusion with culture media and test compounds. Different chamber designs were studied and optimized with regard to dielectrophoretic force distribution, hydrodynamic flow profile, and cell trapping rate using numeric simulations. Based on simulation results a microchip was injection-moulded from COP. This chip allowed the assembly of viable hepatocytes and endothelial cells in a sinusoid-like fashion.

  5. The 3-D alignment of objects in dynamic PET scans using filtered sinusoidal trajectories of sinogram

    International Nuclear Information System (INIS)

    Kostopoulos, Aristotelis E.; Happonen, Antti P.; Ruotsalainen, Ulla

    2006-01-01

    In this study, our goal is to employ a novel 3-D alignment method for dynamic positron emission tomography (PET) scans. Because the acquired data (i.e. sinograms) often contain noise considerably, filtering of the data prior to the alignment presumably improves the final results. In this study, we utilized a novel 3-D stackgram domain approach. In the stackgram domain, the signals along the sinusoidal trajectory signals of the sinogram can be processed separately. In this work, we performed angular stackgram domain filtering by employing well known 1-D filters: the Gaussian low-pass filter and the median filter. In addition, we employed two wavelet de-noising techniques. After filtering we performed alignment of objects in the stackgram domain. The local alignment technique we used is based on similarity comparisons between locus vectors (i.e. the signals along the sinusoidal trajectories of the sinogram) in a 3-D neighborhood of sequences of the stackgrams. Aligned stackgrams can be transformed back to sinograms (Method 1), or alternatively directly to filtered back-projected images (Method 2). In order to evaluate the alignment process, simulated data with different kinds of additive noises were used. The results indicated that the filtering prior to the alignment can be important concerning the accuracy

  6. The Relationship between fenestrations, sieve plates and rafts in liver sinusoidal endothelial cells.

    Directory of Open Access Journals (Sweden)

    Dmitri Svistounov

    Full Text Available Fenestrations are transcellular pores in endothelial cells that facilitate transfer of substrates between blood and the extravascular compartment. In order to understand the regulation and formation of fenestrations, the relationship between membrane rafts and fenestrations was investigated in liver sinusoidal endothelial cells where fenestrations are grouped into sieve plates. Three dimensional structured illumination microscopy, scanning electron microscopy, internal reflectance fluorescence microscopy and two-photon fluorescence microscopy were used to study liver sinusoidal endothelial cells isolated from mice. There was an inverse distribution between sieve plates and membrane rafts visualized by structured illumination microscopy and the fluorescent raft stain, Bodipy FL C5 ganglioside GM1. 7-ketocholesterol and/or cytochalasin D increased both fenestrations and lipid-disordered membrane, while Triton X-100 decreased both fenestrations and lipid-disordered membrane. The effects of cytochalasin D on fenestrations were abrogated by co-administration of Triton X-100, suggesting that actin disruption increases fenestrations by its effects on membrane rafts. Vascular endothelial growth factor (VEGF depleted lipid-ordered membrane and increased fenestrations. The results are consistent with a sieve-raft interaction, where fenestrations form in non-raft lipid-disordered regions of endothelial cells once the membrane-stabilizing effects of actin cytoskeleton and membrane rafts are diminished.

  7. Identification of a single sinusoidal bile salt uptake system in skate liver

    International Nuclear Information System (INIS)

    Fricker, G.; Hugentobler, G.; Meier, P.J.; Kurz, G.; Boyer, J.L.

    1987-01-01

    To identify the sinusoidal bile acid uptake system(s) of skate liver, photoaffinity labeling and kinetic transport studies were performed in isolated plasma membranes as well as intact hepatocytes. In both preparations photoaffinity labeling with the photolabile bile salt derivative revealed the presence of a predominant bile salt binding polypeptide with an apparent molecular weight of 54,000. The [ 3 H]-labeling of this polypeptide was inhibited by taurocholate and cholate in a concentration-dependent manner and was virtually abolished by 1 mM of the anion transport inhibitor 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid. Kinetic studies of hepatic uptake with taurocholate, cholate, and the photoreactive bile salt derivative indicated the involvement of a single transport system, and all three substrates mutually competed with the uptake of each other. Finally, irreversible inhibition of the bile salt uptake system of photoaffinity labeling of hepatocytes with high concentrations of photolabile derivative reduced the V max but the K m of taurocholate uptake. These findings strongly indicate that a single polypeptide with an apparent molecular weight of 54,000 is involved in sinusoidal bile salt uptake into skate hepatocytes. These findings contrast with similar studies in rat liver that implicate both a 54,000- and 48,000-K polypeptide in bile salt uptake and are consistent with a single Na + -independent transport mechanism for hepatic bile salt uptake in this primitive vertebrate

  8. Aerosol absorption measurement with a sinusoidal phase modulating fiber optic photo thermal interferometer

    Science.gov (United States)

    Li, Shuwang; Shao, Shiyong; Mei, Haiping; Rao, Ruizhong

    2016-10-01

    Aerosol light absorption plays an important role in the earth's atmosphere direct and semi-direct radiate forcing, simultaneously, it also has a huge influence on the visibility impairment and laser engineering application. Although various methods have been developed for measuring aerosol light absorption, huge challenge still remains in precision, accuracy and temporal resolution. The main reason is that, as a part of aerosol light extinction, aerosol light absorption always generates synchronously with aerosol light scattering, and unfortunately aerosol light scattering is much stronger in most cases. Here, a novel photo-thermal interferometry is proposed only for aerosol absorption measurement without disturbance from aerosol scattering. The photo-thermal interferometry consists of a sinusoidal phase-modulating single mode fiber-optic interferometer. The thermal dissipation, caused by aerosol energy from photo-thermal conversion when irritated by pump laser through interferometer, is detected. This approach is completely insensitive to aerosol scattering, and the single mode fiber-optic interferometer is compact, low-cost and insensitive to the polarization shading. The theory of this technique is illustrated, followed by the basic structure of the sinusoidal phase-modulating fiber-optic interferometer and demodulation algorithms. Qualitative and quantitative analysis results show that the new photo-thermal interference is a potential approach for aerosol absorption detection and environmental pollution detection.

  9. A Comparison Study of Sinusoidal PWM and Space Vector PWM Techniques for Voltage Source Inverter

    Directory of Open Access Journals (Sweden)

    Ömer Türksoy

    2017-06-01

    Full Text Available In this paper, the methods used to control voltage source inverters which have been intensively investigated in recent years are compared. Although the most efficient result is obtained with the least number of switching elements in the inverter topologies, the method used in the switching is at least as effective as the topology. Besides, the selected switching method to control the inverter will play an effective role in suppressing harmonic components while producing the ideal output voltage. There are many derivatives of pulse width modulation techniques that are commonly used to control voltage source inverters. Some of widespread methods are sinusoidal pulse width modulation and space vector pulse width modulation techniques. These modulation techniques used for generating variable frequency and amplitude output voltage in voltage source inverters, have been simulated by using MATLAB/SIMULINK. And, the total harmonic distortions of the output voltages are compared. As a result of simulation studies, sinusoidal pulse width modulation has been found to have more total harmonic distortion in output voltages of voltage source inverters in the simulation. Space vector pulse width modulation has been shown to produce a more efficient output voltage with less total harmonic distortion.

  10. Controlled generation of nonlinear resonances through sinusoidal lattice modes in Bose–Einstein condensate

    International Nuclear Information System (INIS)

    Das, Priyam; Panigrahi, Prasanta K

    2015-01-01

    We study Bose–Einstein condensate in the combined presence of time modulated optical lattice and harmonic trap in the mean-field approach. Through the self-similar method, we show the existence of sinusoidal lattice modes in this inhomogeneous system, commensurate with the lattice potential. A significant advantage of this system is wide tunability of the parameters through chirp management. The combined effect of the interaction, harmonic trap and lattice potential leads to the generation of nonlinear resonances, exactly where the matter wave changes its direction. When the harmonic trap is switched off, the BEC undergoes a nonlinear compression for the static optical lattice potential. For better understanding of chirp management and the nature of the sinusoidal excitation, we investigate the energy spectrum of the condensate, which clearly reveals the generation of nonlinear resonances in the appropriate regime. We have also identified a classical dynamical phase transition occurring in the system, where loss of superfluidity takes the superfluid phase to an insulating state. (paper)

  11. The Acceptability and Feasibility of Implementing a Bio-Behavioral Enhanced Surveillance Tool for Sexually Transmitted Infections in England: Mixed-Methods Study.

    Science.gov (United States)

    Wayal, Sonali; Reid, David; Blomquist, Paula B; Weatherburn, Peter; Mercer, Catherine H; Hughes, Gwenda

    2018-05-04

    Sexually transmitted infection (STI) surveillance is vital for tracking the scale and pattern of epidemics; however, it often lacks data on the underlying drivers of STIs. This study aimed to assess the acceptability and feasibility of implementing a bio-behavioral enhanced surveillance tool, comprising a self-administered Web-based survey among sexual health clinic attendees, as well as linking this to their electronic health records (EHR) held in England's national STI surveillance system. Staff from 19 purposively selected sexual health clinics across England and men who have sex with men and black Caribbeans, because of high STI burden among these groups, were interviewed to assess the acceptability of the proposed bio-behavioral enhanced surveillance tool. Subsequently, sexual health clinic staff invited all attendees to complete a Web-based survey on drivers of STI risk using a study tablet or participants' own digital device. They recorded the number of attendees invited and participants' clinic numbers, which were used to link survey data to the EHR. Participants' online consent was obtained, separately for survey participation and linkage. In postimplementation phase, sexual health clinic staff were reinterviewed to assess the feasibility of implementing the bio-behavioral enhanced surveillance tool. Acceptability and feasibility of implementing the bio-behavioral enhanced surveillance tool were assessed by analyzing these qualitative and quantitative data. Prior to implementation of the bio-behavioral enhanced surveillance tool, sexual health clinic staff and attendees emphasized the importance of free internet/Wi-Fi access, confidentiality, and anonymity for increasing the acceptability of the bio-behavioral enhanced surveillance tool among attendees. Implementation of the bio-behavioral enhanced surveillance tool across sexual health clinics varied considerably and was influenced by sexual health clinics' culture of prioritization of research and

  12. Enhanced

    Directory of Open Access Journals (Sweden)

    Martin I. Bayala

    2014-06-01

    Full Text Available Land Surface Temperature (LST is a key parameter in the energy balance model. However, the spatial resolution of the retrieved LST from sensors with high temporal resolution is not accurate enough to be used in local-scale studies. To explore the LST–Normalised Difference Vegetation Index relationship potential and obtain thermal images with high spatial resolution, six enhanced image sharpening techniques were assessed: the disaggregation procedure for radiometric surface temperatures (TsHARP, the Dry Edge Quadratic Function, the Difference of Edges (Ts∗DL and three models supported by the relationship of surface temperature and water stress of vegetation (Normalised Difference Water Index, Normalised Difference Infrared Index and Soil wetness index. Energy Balance Station data and in situ measurements were used to validate the enhanced LST images over a mixed agricultural landscape in the sub-humid Pampean Region of Argentina (PRA, during 2006–2010. Landsat Thematic Mapper (TM and Moderate Resolution Imaging Spectroradiometer (EOS-MODIS thermal datasets were assessed for different spatial resolutions (e.g., 960, 720 and 240 m and the performances were compared with global and local TsHARP procedures. Results suggest that the Ts∗DL technique is the most adequate for simulating LST to high spatial resolution over the heterogeneous landscape of a sub-humid region, showing an average root mean square error of less than 1 K.

  13. Strategies for enhancing the implementation of school-based policies or practices targeting risk factors for chronic disease.

    Science.gov (United States)

    Wolfenden, Luke; Nathan, Nicole K; Sutherland, Rachel; Yoong, Sze Lin; Hodder, Rebecca K; Wyse, Rebecca J; Delaney, Tessa; Grady, Alice; Fielding, Alison; Tzelepis, Flora; Clinton-McHarg, Tara; Parmenter, Benjamin; Butler, Peter; Wiggers, John; Bauman, Adrian; Milat, Andrew; Booth, Debbie; Williams, Christopher M

    2017-11-29

    A number of school-based policies or practices have been found to be effective in improving child diet and physical activity, and preventing excessive weight gain, tobacco or harmful alcohol use. Schools, however, frequently fail to implement such evidence-based interventions. The primary aims of the review are to examine the effectiveness of strategies aiming to improve the implementation of school-based policies, programs or practices to address child diet, physical activity, obesity, tobacco or alcohol use.Secondary objectives of the review are to: Examine the effectiveness of implementation strategies on health behaviour (e.g. fruit and vegetable consumption) and anthropometric outcomes (e.g. BMI, weight); describe the impact of such strategies on the knowledge, skills or attitudes of school staff involved in implementing health-promoting policies, programs or practices; describe the cost or cost-effectiveness of such strategies; and describe any unintended adverse effects of strategies on schools, school staff or children. All electronic databases were searched on 16 July 2017 for studies published up to 31 August 2016. We searched the following electronic databases: Cochrane Library including the Cochrane Central Register of Controlled Trials (CENTRAL); MEDLINE; MEDLINE In-Process & Other Non-Indexed Citations; Embase Classic and Embase; PsycINFO; Education Resource Information Center (ERIC); Cumulative Index to Nursing and Allied Health Literature (CINAHL); Dissertations and Theses; and SCOPUS. We screened reference lists of all included trials for citations of other potentially relevant trials. We handsearched all publications between 2011 and 2016 in two specialty journals (Implementation Science and Journal of Translational Behavioral Medicine) and conducted searches of the WHO International Clinical Trials Registry Platform (ICTRP) (http://apps.who.int/trialsearch/) as well as the US National Institutes of Health registry (https://clinicaltrials.gov). We

  14. Core losses of a permanent magnet synchronous motor with an amorphous stator core under inverter and sinusoidal excitations

    Directory of Open Access Journals (Sweden)

    Atsushi Yao

    2018-05-01

    Full Text Available We report core loss properties of permanent magnet synchronous motors (PMSM with amorphous magnetic materials (AMM core under inverter and sinusoidal excitations. To discuss the core loss properties of AMM core, a comparison with non-oriented (NO core is also performed. In addition, based on both experiments and numerical simulations, we estimate higher (time and space harmonic components of the core losses under inverter and sinusoidal excitations. The core losses of PMSM are reduced by about 59% using AMM stator core instead of NO core under sinusoidal excitation. We show that the average decrease obtained by using AMM instead of NO in the stator core is about 94% in time harmonic components.

  15. Calculation of the mean path length of the Epstein frame under non-sinusoidal excitations using the double Epstein method

    International Nuclear Information System (INIS)

    Marketos, Philip; Zurek, Stan; Moses, Anthony J.

    2008-01-01

    This paper discusses the effect of non-sinusoidal excitation on the mean path length of the Epstein frame. Two different steels, a non-oriented (NO) steel and a high-permeability grain-oriented (HGO) electrical steel have been tested under pure sinusoidal and non-sinusoidal excitations and the mean path length of the Epstein frame has been re-calculated. Results indicate that the actual mean path of the Epstein frame depends not only on the material permeability and anisotropy but also on the peak flux density and magnetising frequency. The amount of distortion of the excitation frequency also has an effect on the value of the actual mean path length of the Epstein frame

  16. The FXR agonist PX20606 ameliorates portal hypertension by targeting vascular remodelling and sinusoidal dysfunction.

    Science.gov (United States)

    Schwabl, Philipp; Hambruch, Eva; Seeland, Berit A; Hayden, Hubert; Wagner, Michael; Garnys, Lukas; Strobel, Bastian; Schubert, Tim-Lukas; Riedl, Florian; Mitteregger, Dieter; Burnet, Michael; Starlinger, Patrick; Oberhuber, Georg; Deuschle, Ulrich; Rohr-Udilova, Nataliya; Podesser, Bruno K; Peck-Radosavljevic, Markus; Reiberger, Thomas; Kremoser, Claus; Trauner, Michael

    2017-04-01

    Steroidal farnesoid X receptor (FXR) agonists demonstrated potent anti-fibrotic activities and lowered portal hypertension in experimental models. The impact of the novel non-steroidal and selective FXR agonist PX20606 on portal hypertension and fibrosis was explored in this study. In experimental models of non-cirrhotic (partial portal vein ligation, PPVL, 7days) and cirrhotic (carbon tetrachloride, CCl 4 , 14weeks) portal hypertension, PX20606 (PX,10mg/kg) or the steroidal FXR agonist obeticholic acid (OCA,10mg/kg) were gavaged. We then measured portal pressure, intrahepatic vascular resistance, liver fibrosis and bacterial translocation. PX decreased portal pressure in non-cirrhotic PPVL (12.6±1.7 vs. 10.4±1.1mmHg; p=0.020) and cirrhotic CCl 4 (15.2±0.5 vs. 11.8±0.4mmHg; p=0.001) rats. In PPVL animals, we observed less bacterial translocation (-36%; p=0.041), a decrease in lipopolysaccharide binding protein (-30%; p=0.024) and splanchnic tumour necrosis factor α levels (-39%; p=0.044) after PX treatment. In CCl 4 rats, PX decreased fibrotic Sirius Red area (-43%; p=0.005), hepatic hydroxyproline (-66%; pportal pressure (-14%; p=0.041) by restoring endothelial function, 14week PX therapy additionally inhibited sinusoidal remodelling and decreased portal pressure to a greater extent (-22%; p=0.001). In human liver sinusoidal endothelial cells, PX increased eNOS and DDAH expression. The non-steroidal FXR agonist PX20606 ameliorates portal hypertension by reducing liver fibrosis, vascular remodelling and sinusoidal dysfunction. The novel drug PX20606 activates the bile acid receptor FXR and shows beneficial effects in experimental liver cirrhosis: In the liver, it reduces scarring and inflammation, and also widens blood vessels. Thus, PX20606 leads to an improved blood flow through the liver and decreases hypertension of the portal vein. Additionally, PX20606 improves the altered intestinal barrier and decreases bacterial migration from the gut. Copyright

  17. Enhancing capacity among faith-based organizations to implement evidence-based cancer control programs: a community-engaged approach.

    Science.gov (United States)

    Leyva, Bryan; Allen, Jennifer D; Ospino, Hosffman; Tom, Laura S; Negrón, Rosalyn; Buesa, Richard; Torres, Maria Idalí

    2017-09-01

    Evidence-based interventions (EBIs) to promote cancer control among Latinos have proliferated in recent years, though adoption and implementation of these interventions by faith-based organizations (FBOs) is limited. Capacity building may be one strategy to promote implementation. In this qualitative study, 18 community key informants were interviewed to (a) understand existing capacity for health programming among Catholic parishes, (b) characterize parishes' resource gaps and capacity-building needs implementing cancer control EBIs, and (c) elucidate strategies for delivering capacity-building assistance to parishes to facilitate implementation of EBIs. Semi-structured qualitative interviews were conducted. Key informants concurred about the capacity of Catholic parishes to deliver health programs, and described attributes of parishes that make them strong partners in health promotion initiatives, including a mission to address physical and mental health, outreach to marginalized groups, altruism among members, and existing engagement in health programming. However, resource gaps and capacity building needs were also identified. Specific recommendations participants made about how existing resources might be leveraged to address challenges include to: establish parish wellness committees; provide "hands-on" learning opportunities for parishioners to gain program planning skills; offer continuous, tailored, on-site technical assistance; facilitate relationships between parishes and community resources; and provide financial support for parishes. Leveraging parishes' existing resources and addressing their implementation needs may improve adoption of cancer control EBIs.

  18. Identical phase oscillators with global sinusoidal coupling evolve by Mobius group action.

    Science.gov (United States)

    Marvel, Seth A; Mirollo, Renato E; Strogatz, Steven H

    2009-12-01

    Systems of N identical phase oscillators with global sinusoidal coupling are known to display low-dimensional dynamics. Although this phenomenon was first observed about 20 years ago, its underlying cause has remained a puzzle. Here we expose the structure working behind the scenes of these systems by proving that the governing equations are generated by the action of the Mobius group, a three-parameter subgroup of fractional linear transformations that map the unit disk to itself. When there are no auxiliary state variables, the group action partitions the N-dimensional state space into three-dimensional invariant manifolds (the group orbits). The N-3 constants of motion associated with this foliation are the N-3 functionally independent cross ratios of the oscillator phases. No further reduction is possible, in general; numerical experiments on models of Josephson junction arrays suggest that the invariant manifolds often contain three-dimensional regions of neutrally stable chaos.

  19. Exponential sinusoidal model for predicting temperature inside underground wine cellars from a Spanish region

    Energy Technology Data Exchange (ETDEWEB)

    Mazarron, Fernando R.; Canas, Ignacio [Departamento de Construccion y Vias Rurales, Escuela Tecnica Superior de Ingenieros Agronomos, Universidad Politecnica de Madrid, Avda. Complutense s/n, 28040 Madrid (Spain)

    2008-07-01

    This article develops a mathematical model for determining the annual cycle of air temperature inside traditional underground wine cellars in the Spanish region of ''Ribera del Duero'', known because of the quality of its wines. It modifies the sinusoidal analytical model for soil temperature calculation. Results obtained when contrasting the proposed model with experimental data of three subterranean wine cellars for 2 years are satisfactory. The RMSE is below 1 C and the index of agreement is above 0.96 for the three cellars. When using the average of experimental data corresponding to the 2 years' time, results improve noticeably: the RMSE decreases by more than 30% and the mean d reaches 0.99. This model should be a useful tool for designing underground wine cellars making the most of soil energy advantages. (author)

  20. Real-time detection of musical onsets with linear prediction and sinusoidal modeling

    Science.gov (United States)

    Glover, John; Lazzarini, Victor; Timoney, Joseph

    2011-12-01

    Real-time musical note onset detection plays a vital role in many audio analysis processes, such as score following, beat detection and various sound synthesis by analysis methods. This article provides a review of some of the most commonly used techniques for real-time onset detection. We suggest ways to improve these techniques by incorporating linear prediction as well as presenting a novel algorithm for real-time onset detection using sinusoidal modelling. We provide comprehensive results for both the detection accuracy and the computational performance of all of the described techniques, evaluated using Modal, our new open source library for musical onset detection, which comes with a free database of samples with hand-labelled note onsets.

  1. A pre-heating method based on sinusoidal alternating current for lithium-ion battery

    Science.gov (United States)

    Fan, Wentao; Sun, Fengchun; Guo, Shanshan

    2018-04-01

    In this paper, a method of low temperature pre-heating of sinusoidal alternating current (SAC) is proposed. Generally, the lower the frequency of the AC current, the higher the heat generation rate. Yet at low frequency, there is a risk of lithium-ion deposition during the half cycle of charging. This study develops a temperature-adaptive, deposition-free AC pre-heating method. a equivalent electric circuit(EEC) model is established to predict the heat generation rate and temperature status, whose parameters are calibrated from the EIS impedance measurements. The effects of current frequency and amplitude on the heating effect are investigated respectively. A multistep temperature-adaptive amplitude strategy is proposed and the cell can be heated from -20°C to 5°C within 509s at 100Hz frequency with this method.

  2. A feedback control system for vibration of magnetostrictive plate subjected to follower force using sinusoidal shear

    Directory of Open Access Journals (Sweden)

    A. Ghorbanpour Arani

    2016-03-01

    Full Text Available In this research, the vibrational behavior of magnetostrictive plate (MsP as a smart component is studied. The plate is subjected to an external follower force and a magnetic field in which the vibration response of MsP has been investigated for both loading combinations. The velocity feedback gain parameter is evaluated to study the effect of magnetic field which is generated by the coil. Sinusoidal shear deformation theory is utilized due to its accuracy of polynomial function with respect to other plate theories. Equations of motion are derived using Hamilton’s principle and solved by differential quadrature method (DQM considering general boundary conditions. The effects of aspect ratio, thickness ratio, follower force and velocity feedback gain are investigated on the frequency response of MsP. Results indicate that magneto-mechanical coupling in MsM helps to control vibrational behaviors of systems such as electro-hydraulic actuator, wireless linear Motors and sensors.

  3. Sensitivity of echo enabled harmonic generation to sinusoidal electron beam energy structure

    Directory of Open Access Journals (Sweden)

    E. Hemsing

    2017-06-01

    Full Text Available We analytically examine the bunching factor spectrum of a relativistic electron beam with sinusoidal energy structure that then undergoes an echo-enabled harmonic generation (EEHG transformation to produce high harmonics. The performance is found to be described primarily by a simple scaling parameter. The dependence of the bunching amplitude on fluctuations of critical parameters is derived analytically, and compared with simulations. Where applicable, EEHG is also compared with high gain harmonic generation (HGHG and we find that EEHG is generally less sensitive to several types of energy structure. In the presence of intermediate frequency modulations like those produced by the microbunching instability, EEHG has a substantially narrower intrinsic bunching pedestal.

  4. Iron losses evaluation in soft magnetic materials with a sinusoidal voltage supply

    DEFF Research Database (Denmark)

    Nedelcu, Steluţa; Ritchie, Ewen; Leban, Krisztina Monika

    2013-01-01

    This paper presents an evaluation method of for specific iron losses in non-oriented laminated steel suitable for electric motors and transformers in the case of a sinusoidal excitation. The model is based on the separation of loss contribution due to hysteresis, eddy currents and excess losses...... (between 0.35 mm and 0.65 mm) and alloy compositions. Hysteresis and eddy currents loss coefficients have been considered as dependent on the frequency. For curve fitting of these coefficients third and fourth polynomials were employed, with good result for all the frequencies and magnetic flux density...... and it is proposing an identification procedure for the model coefficients from multi-frequency single sheet tests. The frequencies used are in the range 10 Hz and 150 Hz and with the values of magnetic flux density in the range 0.1 T and 1.4 T. The model was applied on six magnetic materials of different thicknesses...

  5. Tissue responses to fractional transient heating with sinusoidal heat flux condition on skin surface.

    Science.gov (United States)

    Ezzat, Magdy A; El-Bary, Alaa A; Al-Sowayan, Noorah S

    2016-10-01

    A fractional model of Bioheat equation for describing quantitatively the thermal responses of skin tissue under sinusoidal heat flux conditions on skin surface is given. Laplace transform technique is used to obtain the solution in a closed form. The resulting formulation is applied to one-dimensional application to investigate the temperature distribution in skin with instantaneous surface heating for different cases. According to the numerical results and its graphs, conclusion about the fractional bioheat transfer equation has been constructed. Sensitivity analysis is performed to explore the thermal effects of various control parameters on tissue temperature. The comparisons are made with the results obtained in the case of the absence of time-fractional order. © 2016 Japanese Society of Animal Science. © 2016 Japanese Society of Animal Science.

  6. THE LINGUISTICS OF SPEECH PRINCIPLES TO BE IMPLEMENTED IN THE LISTENING COMPREHENSION CLASS TO ENHANCE LEARNERS‟ SPEAKING SKILLS

    OpenAIRE

    Oktavia Tri Sanggala Dewi; Nukmatus Syahria

    2017-01-01

    Linguistics of Speech as linguistic science is about language in use, and the only way to get data is through observations of how language works in real language contexts, and in which the focus is on meaning rather than structure (Kretszmar, W.A.Jr. 2009: 11). The emphasis in meaning is also currently implemented in the implementation of SFL–GBA (Systematic Funtional Linguistic - Genre Based Approach) in Indonesia, in which the use of translation is encouraged (to a certain extend) to improv...

  7. Enhancing the implementation of Occupational Health and Safety interventions through a design of the socio-technical interaction

    DEFF Research Database (Denmark)

    Masi, Donato; Cagno, E.; Hasle, Peter

    2014-01-01

    A multitude of Occupational Health and Safety (OHS) interventions have proven to be effective under controlled conditions, but their implementation in practice is often difficult and interventions may therefore not work as expected, especially when referring to Small and Medium sized Enterprises...

  8. Implementation of an integrating sphere for the enhancement of noninvasive glucose detection using quantum cascade laser spectroscopy

    Science.gov (United States)

    Werth, Alexandra; Liakat, Sabbir; Dong, Anqi; Woods, Callie M.; Gmachl, Claire F.

    2018-05-01

    An integrating sphere is used to enhance the collection of backscattered light in a noninvasive glucose sensor based on quantum cascade laser spectroscopy. The sphere enhances signal stability by roughly an order of magnitude, allowing us to use a thermoelectrically (TE) cooled detector while maintaining comparable glucose prediction accuracy levels. Using a smaller TE-cooled detector reduces form factor, creating a mobile sensor. Principal component analysis has predicted principal components of spectra taken from human subjects that closely match the absorption peaks of glucose. These principal components are used as regressors in a linear regression algorithm to make glucose concentration predictions, over 75% of which are clinically accurate.

  9. NEA and its Role in Enhancing the Implementation of Defence in Depth (DiD) in Light of the Fukushima Dai-ichi Accident

    Energy Technology Data Exchange (ETDEWEB)

    Shimomura, K., E-mail: Kazuo.SHIMOMURA@oecd.org [OECD Nuclear Energy Agency (NEA), Issy-Les-Moulineaux (France)

    2014-10-15

    Full text: This keynote speech will give an overview of NEA Activities to Enhance Global Nuclear Safety both those core to its work and those that have been initiated after the Fukushima Accident. In particular it will highlight the outcomes of the recently published “NEA report on the Fukushima Daiichi Nuclear Power Plant Accident”. The speech will specifically point out those lessons learnt related to Defence in Depth, and how those were fed into the NEA’s one day workshop on “Challenges and Enhancements to DiD in light of the Fukushima Dai-ichi Accident”, that took place on 5th June 2013. A workshop that brought together the member countries represented on the NEA’s three major standing committees for safety to not only discuss the lessons learnt from the accident but also what the NEA members considered could be done to enhance the understanding and implementation of defence in depth within nuclear safety. Members of these three standing committees, the Committee for Nuclear Regulatory Activities (CNRA), The Committee for Safety of Nuclear Installations (CSNI) and the Committee on Radiation Protection and Public Health (CRPPH) represent a considerable body of knowledge on the application of DiD within the countries using nuclear energy. The outcome of the workshop was the identification of a number of key tasks that NEA would take forward to assist in harmonising and enhancing globally the implementation of the DiD philosophy. The speech will in addition detail how the discussions ranged across the whole of the nuclear safety framework, what conclusions were derived and the process the NEA followed to incorporate those tasks within its future programme of work either by enhancing current activities or creating new ones. (author)

  10. A stepped strategy that aims at the nationwide implementation of the Enhanced Recovery After Surgery programme in major gynaecological surgery: study protocol of a cluster randomised controlled trial.

    Science.gov (United States)

    de Groot, Jeanny Ja; Maessen, José Mc; Slangen, Brigitte Fm; Winkens, Bjorn; Dirksen, Carmen D; van der Weijden, Trudy

    2015-07-30

    Enhanced Recovery After Surgery (ERAS) programmes aim at an early recovery after surgical trauma and consequently at a reduced length of hospitalisation. This paper presents the protocol for a study that focuses on large-scale implementation of the ERAS programme in major gynaecological surgery in the Netherlands. The trial will evaluate effectiveness and costs of a stepped implementation approach that is characterised by tailoring the intensity of implementation activities to the needs of organisations and local barriers for change, in comparison with the generic breakthrough strategy that is usually applied in large-scale improvement projects in the Netherlands. All Dutch hospitals authorised to perform major abdominal surgery in gynaecological oncology patients are eligible for inclusion in this cluster randomised controlled trial. The hospitals that already fully implemented the ERAS programme in their local perioperative management or those who predominantly admit gynaecological surgery patients to an external hospital replacement care facility will be excluded. Cluster randomisation will be applied at the hospital level and will be stratified based on tertiary status. Hospitals will be randomly assigned to the stepped implementation strategy or the breakthrough strategy. The control group will receive the traditional breakthrough strategy with three educational sessions and the use of plan-do-study-act cycles for planning and executing local improvement activities. The intervention group will receive an innovative stepped strategy comprising four levels of intensity of support. Implementation starts with generic low-cost activities and may build up to the highest level of tailored and labour-intensive activities. The decision for a stepwise increase in intensive support will be based on the success of implementation so far. Both implementation strategies will be completed within 1 year and evaluated on effect, process, and cost-effectiveness. The primary

  11. Coeur d'Alene Tribe Fisheries Program : Implementation of Fisheries Enhancement Opportunities on the Coeur d'Alene Reservation : 2006 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Vitale, Angelo J.; Hallock, Stephanie A.; Firehammer, Jon A.

    2008-12-12

    This annual report summarizes previously unreported data collected to fulfill the contractual obligations for BPA project No.1990-044-00, 'Coeur d'Alene Subbasin Fisheries Habitat Enhancement', during the 2006 calendar year. Even though the contract performance period for this project crosses fiscal and calendar years, the timing of data collection and analysis, as well as implementation of restoration projects, lends itself to this reporting schedule. The 2006 performance period marked the first year that BPA implemented its Process Improvement Initiative with the Pisces system serving as the vehicle for developing statements of work and tracking project performance. This document attempts to provide some consistency between the project objectives, around which past reports have been structured, and the new work element format adopted for use in Pisces. The report is formatted into three primary sections that respectively provide results and discussion of: (1) monitoring and evaluation of biological and physical habitat indicators; (2) implementation of restoration and enhancement projects; and (3) education and outreach work performed during 2006. The relevant work elements and/or milestones found in the statement of work are listed under these section headings and described in the body of the report.

  12. Middle Managers' Experience of Policy Implementation and Mediation in the Context of the Scottish Quality Enhancement Framework

    Science.gov (United States)

    Saunders, Murray; Sin, Cristina

    2015-01-01

    This paper analyses how middle managers perform and experience their role in enacting policy in Scottish higher education institutions. The policy focus is the quality enhancement framework (QEF) for learning and teaching in higher education, which was launched in 2003. The data-set was collected between 2008 and 2010, during the evaluation of the…

  13. Research on a new magnetic-field-modulated brushless double-rotor machine with sinusoidal-permeance modulating ring

    Directory of Open Access Journals (Sweden)

    Ping Zheng

    2017-05-01

    Full Text Available The magnetic-field-modulated brushless double-rotor machine (MFM-BDRM, composed of a stator, a modulating ring rotor, and a PM rotor, is a kind of power-split device for hybrid electric vehicles (HEVs. In this paper, a new MFM-BDRM with sinusoidal-permeance modulating ring named Sinusoidal-Permeance-Modulating-Ring Brushless Double-Rotor Machine (SPMR-BDRM is proposed to solve the problem of poor mechanical strength and large iron loss. The structure and the operating principle of the MFM-BDRM are introduced. The design principle of the sinusoidal-permeance modulating ring is analyzed and derived. The main idea of that is to minimize the harmonic permeance of air gap, thereby the harmonic magnetic fields can be restrained. There are comparisons between a MFM-BDRM with sinusoidal-permeance modulating ring and a same size MFM-BDRM with traditional modulating ring, including magnetic field distributions and electromagnetic performances. Most importantly, the iron losses are compared under six different conditions. The result indicates that the harmonic magnetic fields in the air gap are restrained; the electromagnetic torque and power factor are almost the same with same armature current; the torque ripples of the modulating ring rotor and the PM rotor are reduced; the stator loss is reduced by 13% at least and the PM loss is reduced by 20% at least compared with the same size traditional MFM-BDRM under the same operating conditions.

  14. Additional Energy Losses from Asymmetric and Non-Sinusoidal Current in an Electrical Facility and Methods of their Reduction

    OpenAIRE

    Tarasov, Evgeny Vladimirovich; Bulyga, Leonid Leonidovich; Ushakov, Vasily Yakovlevich; Kharlov, Nikolay Nikolaevich

    2015-01-01

    Influence of the asymmetry and higher harmonics of current on the operation of an electrical facility is analyzed. The level of additional losses from the asymmetric and non-sinusoidal currents is evaluated for a 110 kV electrical network in the Siberian Region of the Russian Federation. Methods for reducing the additional energy losses in the electrical facility are suggested.

  15. Generation of sinusoidal fringes with a holographic phase grating and a phase-only spatial light modulator

    International Nuclear Information System (INIS)

    Berberova, Natalia; Stoykova, Elena; Sainov, Ventseslav

    2012-01-01

    A variety of pattern projection methods for the three-dimensional capture of objects is based on the generation of purely sinusoidal fringes. This is not an easy task, especially when a portable non-interferometric system for outdoor usage is required. The use of phase gratings with coherent illumination as a possible solution has the advantage of providing good stability and a large measurement volume. In this work, we analyze the quality of fringes projected with two sinusoidal phase gratings. The first grating is recorded on a silver-halide holographic plate by means of a Michelson interferometer. The spatial resolution of the silver-halide material used is greater than 6000 lines per millimeter, and the recorded grating is practically analogous to a smooth variation of the phase profile. The second grating is formed as a sinusoidal phase variation on a liquid crystal-on-silicon phase-only reflective display with a resolution of 1920×1080 pixels, a pixel pitch of 8 μm and 256 phase levels. The frequency content of the fringes projected with both gratings is analyzed and compared on the basis of the calculated Fresnel diffraction pattern, taking into account that the sinusoidal phase distribution in the case of a spatial light modulator is both sampled and quantized. Experimental fringe patterns projected using both gratings are also provided.

  16. Diagnosis of sinusoidal obstruction syndrome by positron emission tomography/computed tomography: report of two cases treated by defibrotide.

    Science.gov (United States)

    Gauthé, Mathieu; Bozec, Laurence; Bedossa, Pierre

    2014-11-01

    Sinusoidal obstruction syndrome (SOS) is a potentially fatal liver injury that mainly occurs after myeloablative chemotherapy. We report two cases of SOS investigated by 18F-fluorodeoxyglucose positron emission tomography/computed tomography and treated with defibrotide. © 2014 by the American Association for the Study of Liver Diseases.

  17. Adaptation and implementation of family-based treatment enhanced with dialectical behavior therapy skills for anorexia nervosa in community-based specialist clinics.

    Science.gov (United States)

    Accurso, Erin C; Astrachan-Fletcher, Ellen; O'Brien, Setareh; McClanahan, Susan F; Le Grange, Daniel

    2018-01-01

    Although family-based therapy (FBT) is a well-established treatment for anorexia nervosa, its implementation and effectiveness in clinical settings has been neglected. A group of seven therapists at a community-based eating disorders clinic were trained in skills-enhanced FBT and provided treatment to 11 youth with anorexia nervosa. Family-based skills training, which borrowed heavily from dialectical behavior therapy, was introduced in four additional sessions and then integrated throughout the remainder of FBT. FBT was perceived as appropriate and acceptable by all participants. Therapists reported high treatment fidelity. There was a large improvement in weight and moderate improvement in caregiver-reported eating disorder psychopathology but no clinically significant change by youth report. This study provides preliminary data on the implementation and effectiveness of FBT in the community.

  18. Development of a theory- and evidence-based intervention to enhance implementation of physical therapy guidelines for the management of low back pain.

    Science.gov (United States)

    Rutten, Geert M; Harting, Janneke; Bartholomew, Leona K; Braspenning, Jozé C; van Dolder, Rob; Heijmans, Marcel Fgj; Hendriks, Erik Jm; Kremers, Stef Pj; van Peppen, Roland Ps; Rutten, Steven Tj; Schlief, Angelique; de Vries, Nanne K; Oostendorp, Rob Ab

    2014-01-15

    Systematic planning could improve the generally moderate effectiveness of interventions to enhance adherence to clinical practice guidelines. The aim of our study was to demonstrate how the process of Intervention Mapping was used to develop an intervention to address the lack of adherence to the national CPG for low back pain by Dutch physical therapists. We systematically developed a program to improve adherence to the Dutch physical therapy guidelines for low back pain. Based on multi-method formative research, we formulated program and change objectives. Selected theory-based methods of change and practical applications were combined into an intervention program. Implementation and evaluation plans were developed. Formative research revealed influential determinants for physical therapists and practice quality managers. Self-regulation was appropriate because both the physical therapists and the practice managers needed to monitor current practice and make and implement plans for change. The program stimulated interaction between practice levels by emphasizing collective goal setting. It combined practical applications, such as knowledge transfer and discussion-and-feedback, based on theory-based methods, such as consciousness raising and active learning. The implementation plan incorporated the wider environment. The evaluation plan included an effect and process evaluation. Intervention Mapping is a useful framework for formative data in program planning in the field of clinical guideline implementation. However, a decision aid to select determinants of guideline adherence identified in the formative research to analyse the problem may increase the efficiency of the application of the Intervention Mapping process.

  19. Combining Geoelectrical Measurements and CO 2 Analyses to Monitor the Enhanced Bioremediation of Hydrocarbon-Contaminated Soils: A Field Implementation

    OpenAIRE

    Noel , Cécile; Gourry , Jean-Christophe; Deparis , Jacques; Blessing , Michaela; Ignatiadis , Ioannis; Guimbaud , Christophe

    2016-01-01

    International audience; Hydrocarbon-contaminated aquifers can be successfully remediated through enhanced biodegradation. However, in situ monitoring of the treatment by piezometers is expensive and invasive and might be insufficient as the information provided is restricted to vertical profiles at discrete locations. An alternative method was tested in order to improve the robustness of the monitoring. Geophysical methods, electrical resistivity (ER) and induced polarization (IP), were combi...

  20. Activities of the Oil Implementation Task Force; Contracts for field projects and supporting research on enhanced oil recovery, July--September 1990

    Energy Technology Data Exchange (ETDEWEB)

    Tiedemann, H.A. (ed.) (USDOE Bartlesville Project Office, OK (USA))

    1991-05-01

    The report contains a general introduction and background to DOE's revised National Energy Strategy Advanced Oil Recovery Program and activities of the Oil Implementation Task Force; a detailed synopsis of the symposium, including technical presentations, comments and suggestions; a section of technical information on deltaic reservoirs; and appendices containing a comprehensive listing of references keyed to general deltaic and geological aspects of reservoirs and those relevant to six selected deltaic plays. Enhanced recovery processes include chemical floodings, gas displacement, thermal recovery, geoscience, and microbial recovery.

  1. The evaluation of distributed damage in concrete based on sinusoidal modeling of the ultrasonic response.

    Science.gov (United States)

    Sepehrinezhad, Alireza; Toufigh, Vahab

    2018-05-25

    Ultrasonic wave attenuation is an effective descriptor of distributed damage in inhomogeneous materials. Methods developed to measure wave attenuation have the potential to provide an in-site evaluation of existing concrete structures insofar as they are accurate and time-efficient. In this study, material classification and distributed damage evaluation were investigated based on the sinusoidal modeling of the response from the through-transmission ultrasonic tests on polymer concrete specimens. The response signal was modeled as single or the sum of damping sinusoids. Due to the inhomogeneous nature of concrete materials, model parameters may vary from one specimen to another. Therefore, these parameters are not known in advance and should be estimated while the response signal is being received. The modeling procedure used in this study involves a data-adaptive algorithm to estimate the parameters online. Data-adaptive algorithms are used due to a lack of knowledge of the model parameters. The damping factor was estimated as a descriptor of the distributed damage. The results were compared in two different cases as follows: (1) constant excitation frequency with varying concrete mixtures and (2) constant mixture with varying excitation frequencies. The specimens were also loaded up to their ultimate compressive strength to investigate the effect of distributed damage in the response signal. The results of the estimation indicated that the damping was highly sensitive to the change in material inhomogeneity, even in comparable mixtures. In addition to the proposed method, three methods were employed to compare the results based on their accuracy in the classification of materials and the evaluation of the distributed damage. It is shown that the estimated damping factor is not only sensitive to damage in the final stages of loading, but it is also applicable in evaluating micro damages in the earlier stages providing a reliable descriptor of damage. In addition

  2. Flow and axial dispersion in a sinusoidal-walled tube: Effects of inertial and unsteady flows

    Science.gov (United States)

    Richmond, Marshall C.; Perkins, William A.; Scheibe, Timothy D.; Lambert, Adam; Wood, Brian D.

    2013-12-01

    In this work, we consider a sinusoidal-walled tube (a three-dimensional tube with sinusoidally-varying diameter) as a simplified conceptualization of flow in porous media. Direct numerical simulation using computational fluid dynamics (CFD) methods was used to compute velocity fields by solving the Navier-Stokes equations, and also to numerically solve the volume averaging closure problem, for a range of Reynolds numbers (Re) spanning the low-Re to inertial flow regimes, including one simulation at Re=449 for which unsteady flow was observed. The longitudinal dispersion observed for the flow was computed using a random walk particle tracking method, and this was compared to the longitudinal dispersion predicted from a volume-averaged macroscopic mass balance using the method of volume averaging; the results of the two methods were consistent. Our results are compared to experimental measurements of dispersion in porous media and to previous theoretical results for both the low-Re, Stokes flow regime and for values of Re representing the steady inertial regime. In the steady inertial regime, a power-law increase in the effective longitudinal dispersion (DL) with Re was found, and this is consistent with previous results. This rapid rate of increase is caused by trapping of solute in expansions due to flow separation (eddies). One unsteady (but non-turbulent) flow case (Re=449) was also examined. For this case, the rate of increase of DL with Re was smaller than that observed at lower Re. Velocity fluctuations in this regime lead to increased rates of solute mass transfer between the core flow and separated flow regions, thus diminishing the amount of tailing caused by solute trapping in eddies and thereby reducing longitudinal dispersion. The observed tailing was further explored through analysis of concentration skewness (third moment) and its assymptotic convergence to conventional advection-dispersion behavior (skewness = 0). The method of volume averaging was

  3. Implementation of Enhanced Attenuation at the DOE Mound Site OU-1 Landfill: Accelerating Progress and Reducing Costs

    Energy Technology Data Exchange (ETDEWEB)

    Hooten, Gwendolyn [U.S. Department of Energy, Office of Legacy Management; Cato, Rebecca [Navarro Research and Engineering; Looney, Brian [Savannah River National Laboratory, Aiken, SC

    2016-03-06

    At the US Department of Energy (DOE), Office of Legacy Management, Mound, Ohio, Site, chlorinated organic contaminants (cVOCs) originating from the former solid-waste landfill have impacted groundwater in Operable Unit 1 (OU-1). The baseline groundwater remedy was groundwater pump and treat (P&T). Since the source materials have been removed from the landfill, the Mound core team, which consists of DOE, US Environmental Protection Agency (US EPA), Ohio EPA, and other stakeholders, is assessing the feasibility of switching from the active P&T remedy to a passive attenuation-based remedy. Toward this end, an enhanced attenuation (EA) strategy based on the creation of structured geochemical zones was developed. This EA strategy addresses the residual areas of elevated cVOCs in soil and groundwater while minimizing the rebound of groundwater concentrations above regulatory targets (e.g., maximum contaminant levels [MCLs]) and avoiding plume expansion while the P&T system is turned off. The EA strategy has improved confidence and reduced risk on the OU-1 groundwater transition path to monitored natural attenuation (MNA). To better evaluate the EA strategy, DOE is conducting a field demonstration to evaluate the use of edible oils to enhance the natural attenuation processes. The field demonstration is designed to determine whether structured geochemical zones can be established that expedite the attenuation of cVOCs in the OU-1 groundwater. The EA approach at OU-1 was designed based on “structured geochemical zones” and relies on groundwater flow through a succession of anaerobic and aerobic zones. The anaerobic zones stimulate relatively rapid degradation of the original solvent source compounds (e.g., cVOCs such as tetrachloroethene [PCE] and trichloroethene [TCE]). The surrounding aerobic areas encourage relatively rapid degradation of daughter products (such as dichloroethene [DCE] and vinyl chloride [VC]) as well as enhanced cometabolism of TCE resulting from

  4. Implementation and Effectiveness of Early Chest Tube Removal during an Enhanced Recovery Programme after Oesophago-gastrectomy

    Directory of Open Access Journals (Sweden)

    Rajeev Bhandari

    2015-03-01

    Full Text Available Introduction: Oesophageal resection were notoriously complicated and produces a cohort of patients prone to postoperative complications and here we would like to focus on the implementation and effectiveness of early chest tube removal in ERAS after oesophago-gastrectomy considering the various aspect like pleural effusion and reducing the length of hospital stay which ultimately lead to reducing the economic burden on patient. Methods: An ERAS programme was devised and implemented with the support of a dedicated in-hospital task-force. The patients underwent esophago-gastrectomy were randomly divided into two groups: the ERAS group and the control group (non-ERAS. The ERAS group was treated with early removal of the chest tube after surgery, and the control group was treated with traditional way and outcomes were compared between them. Results: The length of hospital stay and the cost of hospitalization in the ERAS group were significantly lower than those in the control group(p<0.05. However, there was no statistical significant difference in the incidences of pleural effusion between the two groups(p>0.05. Conclusions: The introduction of early chest tube removal as an ERAS programme after oesophago-gastrectomy would not increase the risk of pleural effusion and would not increase the total length of stay and cost of hospitalisation without jeopardising patient safety or clinical outcomes.

  5. A metabonomic evaluation of the monocrotaline-induced sinusoidal obstruction syndrome (SOS) in rats

    International Nuclear Information System (INIS)

    Conotte, R.; Colet, J.-M.

    2014-01-01

    The main curative treatment of colorectal cancer remains the surgery. However, when metastases are suspected, surgery is followed by a preventive chemotherapy using oxaliplatin which, unfortunately, may cause liver sinusoidal obstruction syndrome (SOS). Such hepatic damage is barely detected during or after chemotherapy due to a lack of effective diagnostic procedures, but liver biopsy. The primary objective of the present study was to identify potential early diagnosis biomarkers of SOS using a metabonomic approach. SOS was induced in rats by monocrotaline, a prototypical toxic substance. 1 H NMR spectroscopy analysis of urine samples collected from rats treated with monocrotaline showed significant metabolic changes as compared to controls. During a first phase, cellular protective mechanisms such as an increased synthesis of GSH (reduced taurine) and the recruitment of cell osmolytes in the liver (betaine) were seen. In the second phase, the disturbance of the urea cycle (increased ornithine and urea reduction) leading to the depletion of NO, the alteration in the GSH synthesis (increased creatine and GSH precursors (glutamate, dimethylglycine and sarcosine)), and the liver necrosis (decrease taurine and increase creatine) all indicate the development of SOS. - Highlights: • Urine metabonomic profiles of SOS have been identified. • Urine osmoprotectants and anti-oxidants indicated an initial liver protection. • Liver necrosis was demonstrated by increased urine levels of taurine and creatine. • NO depletion was suggested by changes in ornithine and urea

  6. Liver sinusoidal endothelial cells induce immunosuppressive IL-10-producing Th1 cells via the Notch pathway.

    Science.gov (United States)

    Neumann, Katrin; Rudolph, Christine; Neumann, Christian; Janke, Marko; Amsen, Derk; Scheffold, Alexander

    2015-07-01

    Under homeostasis, liver sinusoidal endothelial cells (LSECs) shift intrahepatic T-cell responses towards tolerance. However, the role of LSECs in the regulation of T-cell-induced liver inflammation is less clear. Here, we studied the capacity of LSECs to modulate pro-inflammatory Th1-cell differentiation in mice. Using in vitro co-culture systems and subsequent cytokine analysis, we showed that LSECs induced high amounts of the anti-inflammatory cytokine IL-10 in developing Th1 cells. These LSEC-stimulated Th1 cells had no pro-inflammatory capacity in vivo but instead actively suppressed an inflammatory Th1-cell-induced delayed-type hypersensitivity reaction. Blockage of IL-10 signaling in vivo inhibited immunosuppressive activity of LSEC-stimulated Th1 cells. We identified the Notch pathway as a mechanism how LSECs trigger IL-10 expression in Th1 cells. LSECs expressed high levels of the Delta-like and Jagged family of Notch ligands and induced expression of the Notch target genes hes-1 and deltex-1 in Th1 cells. Blockade of Notch signaling selectively inhibited IL-10 induction in Th1 cells by LSECs. Our findings suggest that LSEC-induced IL-10 expression in Th1 cells via the Notch pathway may contribute to the control of hepatic inflammatory immune responses by induction of a self-regulatory mechanism in pro-inflammatory Th1 cells. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. Using spatiotemporal source separation to identify prominent features in multichannel data without sinusoidal filters.

    Science.gov (United States)

    Cohen, Michael X

    2017-09-27

    The number of simultaneously recorded electrodes in neuroscience is steadily increasing, providing new opportunities for understanding brain function, but also new challenges for appropriately dealing with the increase in dimensionality. Multivariate source separation analysis methods have been particularly effective at improving signal-to-noise ratio while reducing the dimensionality of the data and are widely used for cleaning, classifying and source-localizing multichannel neural time series data. Most source separation methods produce a spatial component (that is, a weighted combination of channels to produce one time series); here, this is extended to apply source separation to a time series, with the idea of obtaining a weighted combination of successive time points, such that the weights are optimized to satisfy some criteria. This is achieved via a two-stage source separation procedure, in which an optimal spatial filter is first constructed and then its optimal temporal basis function is computed. This second stage is achieved with a time-delay-embedding matrix, in which additional rows of a matrix are created from time-delayed versions of existing rows. The optimal spatial and temporal weights can be obtained by solving a generalized eigendecomposition of covariance matrices. The method is demonstrated in simulated data and in an empirical electroencephalogram study on theta-band activity during response conflict. Spatiotemporal source separation has several advantages, including defining empirical filters without the need to apply sinusoidal narrowband filters. © 2017 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

  8. Bevacizumab exacerbates sinusoidal obstruction syndrome (SOS) in the animal model and increases MMP 9 production.

    Science.gov (United States)

    Jafari, Azin; Matthaei, Hanno; Wehner, Sven; Tonguc, Tolga; Kalff, Jörg C; Manekeller, Steffen

    2018-04-24

    Thanks to modern multimodal treatment the ouctome of patients with colorectal cancer has experienced significant improvements. As a downside, agent specific side effects have been observed such as sinusoidal obstruction syndrome (SOS) after oxaliplatin chemotherapy (OX). Bevazicumab targeting VEGF is nowadays comprehensively used in combination protocols with OX but its impact on hepatotoxicity is thus far elusive and focus of the present study. After MCT administration 67% of animals developed SOS. GOT serum concentration significantly increased in animals developing SOS ( p SOS. In contrast, animals receiving VEGF developed SOS merely in 40% while increasing the VEGF dose led to a further decrease in SOS development to 25%. MMP 9 concentration in animals developing SOS was significantly higher compared to controls ( p SOS paralleled by MMP 9 production. Therefore, OX-Bevacizumab combination therapies should be administered with caution, especially if liver parenchyma damage is apparent. Male Sprague-Dawley rats were gavaged Monocrotaline (MCT) to induce SOS. Recombinant VEGF or an Anti-VEGF antibody was administered to MCT-treated rats and the hepatotoxic effect monitored in defined time intervals. MMP 9 expression in the liver was measured by ELISA.

  9. A metabonomic evaluation of the monocrotaline-induced sinusoidal obstruction syndrome (SOS) in rats

    Energy Technology Data Exchange (ETDEWEB)

    Conotte, R.; Colet, J.-M., E-mail: jean-marie.colet@umons.ac.be

    2014-04-15

    The main curative treatment of colorectal cancer remains the surgery. However, when metastases are suspected, surgery is followed by a preventive chemotherapy using oxaliplatin which, unfortunately, may cause liver sinusoidal obstruction syndrome (SOS). Such hepatic damage is barely detected during or after chemotherapy due to a lack of effective diagnostic procedures, but liver biopsy. The primary objective of the present study was to identify potential early diagnosis biomarkers of SOS using a metabonomic approach. SOS was induced in rats by monocrotaline, a prototypical toxic substance. {sup 1}H NMR spectroscopy analysis of urine samples collected from rats treated with monocrotaline showed significant metabolic changes as compared to controls. During a first phase, cellular protective mechanisms such as an increased synthesis of GSH (reduced taurine) and the recruitment of cell osmolytes in the liver (betaine) were seen. In the second phase, the disturbance of the urea cycle (increased ornithine and urea reduction) leading to the depletion of NO, the alteration in the GSH synthesis (increased creatine and GSH precursors (glutamate, dimethylglycine and sarcosine)), and the liver necrosis (decrease taurine and increase creatine) all indicate the development of SOS. - Highlights: • Urine metabonomic profiles of SOS have been identified. • Urine osmoprotectants and anti-oxidants indicated an initial liver protection. • Liver necrosis was demonstrated by increased urine levels of taurine and creatine. • NO depletion was suggested by changes in ornithine and urea.

  10. Broadband frequency and angular response of a sinusoidal bull’s eye antenna

    Science.gov (United States)

    Beaskoetxea, U.; Navarro-Cía, M.; Beruete, M.

    2016-07-01

    A thorough experimental study of the frequency and beaming angle response of a metallic leaky-wave bull’s eye antenna working at 77 GHz with a sinusoidally corrugated profile is presented. The beam scanning property of these antennas as frequency is varied is experimentally demonstrated and corroborated through theoretical and numerical results. From the experimental results the dispersion diagram of the n  =  -1 and n  =  -2 space harmonics is extracted, and the operation at different frequency regimes is identified and discussed. In order to show the contribution of each half of the antenna, numerical examples of the near-field behavior are also displayed. Overall, experimental results are in good qualitative and quantitative agreement with theoretical and numerical calculations. Finally, an analysis of the beamwidth as a function of frequency is performed, showing that it can achieve values below 1.5° in a fractional bandwidth of 4% around the operation frequency, which is an interesting frequency-stable broadside radiation.

  11. Broadband frequency and angular response of a sinusoidal bull’s eye antenna

    International Nuclear Information System (INIS)

    Beaskoetxea, U; Beruete, M; Navarro-Cía, M

    2016-01-01

    A thorough experimental study of the frequency and beaming angle response of a metallic leaky-wave bull’s eye antenna working at 77 GHz with a sinusoidally corrugated profile is presented. The beam scanning property of these antennas as frequency is varied is experimentally demonstrated and corroborated through theoretical and numerical results. From the experimental results the dispersion diagram of the n   =  −1 and n   =  −2 space harmonics is extracted, and the operation at different frequency regimes is identified and discussed. In order to show the contribution of each half of the antenna, numerical examples of the near-field behavior are also displayed. Overall, experimental results are in good qualitative and quantitative agreement with theoretical and numerical calculations. Finally, an analysis of the beamwidth as a function of frequency is performed, showing that it can achieve values below 1.5° in a fractional bandwidth of 4% around the operation frequency, which is an interesting frequency-stable broadside radiation. (paper)

  12. Experimental study of fluid flow in the entrance of a sinusoidal channel

    International Nuclear Information System (INIS)

    Oviedo-Tolentino, F.; Romero-Mendez, R.; Hernandez-Guerrero, A.; Giron-Palomares, B.

    2008-01-01

    An experimental flow visualization study of the entrance section of channels formed with sinusoidal plates was made. The experiments were conducted in a water tunnel and a laser illuminated particle tracking was used as the technique of flow visualization. The geometric parameters of the plates were maintained constant while the distance between plates, phase angle, and the Reynolds number were varied during the experiments. The flow regimes that were found in the experiments are steady, unsteady and significantly-mixed flows. Instabilities of the flow first appear near the exit of the channel, and move closer to the inlet waves as the Reynolds number grows, but in the first wave from inlet the flow is always steady. The results show that, for all other parameters fixed, the Reynolds number at which unsteady flow first appears grows with the distance between plates. The phase angle that best promotes unsteady flow depends on the average distance between plates: for certain average distance between plates, there is a phase angle that best disturbs the flow. For the set of parameters used in this experiment, a channel with eight waves is sufficiently long and the flow features presented in the first eight waves of a longer channel will be similar to what was observed here

  13. Richtmyer-Meshkov instability of a sinusoidal interface driven by a cylindrical shock

    Science.gov (United States)

    Liu, L.; Ding, J.; Zhai, Z.; Luo, X.

    2018-04-01

    Evolution of a single-mode interface triggered by a cylindrically converging shock in a V-shaped geometry is investigated numerically using an adaptive multi-phase solver. Several physical mechanisms, including the Bell-Plesset (BP) effect, the Rayleigh-Taylor (RT) effect, the nonlinearity, and the compressibility are found to be pronounced in the converging environment. Generally, the BP and nonlinear effects play an important role at early stages, while the RT effect and the compressibility dominate the late-stage evolution. Four sinusoidal interfaces with different initial amplitudes (a_0 ) and wavelengths (λ ) are found to evolve differently in the converging geometry. For the very small a_0 /λ interfaces, nonlinearity is negligible at the early stages and the sole presence of the BP effect results in an increasing growth rate, confining the linear growth of the instability to a relatively small amount of time. For the moderately small a_0 /λ cases, the BP and nonlinear effects, which, respectively, promote and inhibit the perturbation development, coexist in the early stage. The counterbalancing effects between them produce a very long period of growth that is linear in time, even to a moment when the amplitude over wavelength ratio approaches 0.6. The RT stabilization effect at late stages due to the interface deceleration significantly inhibits the perturbation growth, which can be reasonably predicted by a modified Bell model.

  14. Instrumentation to Measure the Capacitance of Biosensors by Sinusoidal Wave Method

    Directory of Open Access Journals (Sweden)

    Pavan Kumar KATHUROJU

    2009-09-01

    Full Text Available Micro Controller based instrumentation to measure the capacitance of biosensors is developed. It is based on frequency domain technique with sinusoidal wave input. Changes in the capacitance of biosensor because of the analyte specific reaction are calculated by knowing the current flowing through the sample. A dedicated 8-bit microcontroller (AT89C52 and its associated peripherals are employed for the hardware and application specific software is developed in ‘C’ language. The paper describes the methodology, instrumentation details along with a specific application to glucose sensing. The measurements are conducted with glucose oxidase based capacitance biosensor and the obtained results are compared with the conventional method of sugar measurements using the UV-Visible spectroscopy (Phenol-Sulphuric acid assay method. Measurement accuracy of the instrument is found to be ± 5 %. Experiments are conducted on glucose sensor with different bias voltages. It is found that for bias voltages varying from 0.5 to 0.7 Volt, the measurements are good for this application.

  15. Fine tuning of optical signals in nanoporous anodic alumina photonic crystals by apodized sinusoidal pulse anodisation.

    Science.gov (United States)

    Santos, Abel; Law, Cheryl Suwen; Chin Lei, Dominique Wong; Pereira, Taj; Losic, Dusan

    2016-11-03

    In this study, we present an advanced nanofabrication approach to produce gradient-index photonic crystal structures based on nanoporous anodic alumina. An apodization strategy is for the first time applied to a sinusoidal pulse anodisation process in order to engineer the photonic stop band of nanoporous anodic alumina (NAA) in depth. Four apodization functions are explored, including linear positive, linear negative, logarithmic positive and logarithmic negative, with the aim of finely tuning the characteristic photonic stop band of these photonic crystal structures. We systematically analyse the effect of the amplitude difference (from 0.105 to 0.840 mA cm -2 ), the pore widening time (from 0 to 6 min), the anodisation period (from 650 to 950 s) and the anodisation time (from 15 to 30 h) on the quality and the position of the characteristic photonic stop band and the interferometric colour of these photonic crystal structures using the aforementioned apodization functions. Our results reveal that a logarithmic negative apodisation function is the most optimal approach to obtain unprecedented well-resolved and narrow photonic stop bands across the UV-visible-NIR spectrum of NAA-based gradient-index photonic crystals. Our study establishes a fully comprehensive rationale towards the development of unique NAA-based photonic crystal structures with finely engineered optical properties for advanced photonic devices such as ultra-sensitive optical sensors, selective optical filters and all-optical platforms for quantum computing.

  16. Measurement of electroosmotic and electrophoretic velocities using pulsed and sinusoidal electric fields.

    Science.gov (United States)

    Sadek, Samir H; Pimenta, Francisco; Pinho, Fernando T; Alves, Manuel A

    2017-04-01

    In this work, we explore two methods to simultaneously measure the electroosmotic mobility in microchannels and the electrophoretic mobility of micron-sized tracer particles. The first method is based on imposing a pulsed electric field, which allows to isolate electrophoresis and electroosmosis at the startup and shutdown of the pulse, respectively. In the second method, a sinusoidal electric field is generated and the mobilities are found by minimizing the difference between the measured velocity of tracer particles and the velocity computed from an analytical expression. Both methods produced consistent results using polydimethylsiloxane microchannels and polystyrene micro-particles, provided that the temporal resolution of the particle tracking velocimetry technique used to compute the velocity of the tracer particles is fast enough to resolve the diffusion time-scale based on the characteristic channel length scale. Additionally, we present results with the pulse method for viscoelastic fluids, which show a more complex transient response with significant velocity overshoots and undershoots after the start and the end of the applied electric pulse, respectively. © 2016 The Authors. Electrophoresis published by Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. Flagellum motion in 2-D: Work rate and efficiency of the non-sinusoidal approach

    Science.gov (United States)

    Viridi, Sparisoma; Nuraini, Nuning; Stephanie, Monica; Rifqi, Ainur; Christina, Dina; Thania, Elsa; Sihite, Erland

    2018-03-01

    Today microorganisms have been widely used to support human life. Some examples include foodstuffs (Spirulina.sp), to help with medical needs, for mining purposes and more. On the other hand, the development of technology is also very big influence on human life. The combination of technology and health science will be very useful if we can develop it. One is the cancer treatment by utilizing the movement of the flagella to be made a nanorobot used as a carrier of cancer drugs. Movement of flagella that resembles the shape of the arc and straight line can be searched formulation and then applied to the manufacture of nanorobot tail. Then the nanorobot will carry a cancer drug that leads directly to the cancer cells. So hopefully with this nanorobot, can minimize the death of healthy cells around cancer cells. From the results of research and analysis of the movement of flagella, it can be concluded that the smaller the mass of the flagella, the greater the efficiency will be or will be more efficient. So, the energy needed nanorobot will be smaller. Model with non-sinusoidal approach (Brokaw, 1965) is discussed in this work and formulation to get the energy efficiency is proposed and analyzed. Unfortunately, there is a negative value in the formulation.

  18. Sensorless Sinusoidal Drives for Fan and Pump Motors by V/f Control

    Science.gov (United States)

    Kiuchi, Mitsuyuki; Ohnishi, Tokuo

    This paper proposes sensorless sinusoidal driving methods of permanent magnet synchronous motors for fans and pumps by V/f control. The proposed methods are simple methods that control the motor peak current constant by voltage or frequency control, and are characterized by DC link current detection using a single shunt resistor at carrier wave signal bottom timing. As a result of the dumping factor from square torque load characteristics of fan and pump motors, it is possible to control stable starting and stable steady state by V/f control. In general, pressure losses as a result of the fluid pass of fan and pump systems are nearly constant; therefore, the flow rate and motor torque are determined by revolutions. Accordingly, high efficiency driving is possible by setting corresponding currents to q-axis currents (torque currents) at target revolutions. Because of the simple current detection and motor control methods, the proposed methods are optimum for fan and pump motor driving systems of home appliances.

  19. Sinusoidal Parameter Estimation Using Quadratic Interpolation around Power-Scaled Magnitude Spectrum Peaks

    Directory of Open Access Journals (Sweden)

    Kurt James Werner

    2016-10-01

    Full Text Available The magnitude of the Discrete Fourier Transform (DFT of a discrete-time signal has a limited frequency definition. Quadratic interpolation over the three DFT samples surrounding magnitude peaks improves the estimation of parameters (frequency and amplitude of resolved sinusoids beyond that limit. Interpolating on a rescaled magnitude spectrum using a logarithmic scale has been shown to improve those estimates. In this article, we show how to heuristically tune a power scaling parameter to outperform linear and logarithmic scaling at an equivalent computational cost. Although this power scaling factor is computed heuristically rather than analytically, it is shown to depend in a structured way on window parameters. Invariance properties of this family of estimators are studied and the existence of a bias due to noise is shown. Comparing to two state-of-the-art estimators, we show that an optimized power scaling has a lower systematic bias and lower mean-squared-error in noisy conditions for ten out of twelve common windowing functions.

  20. Defibrotide sodium for the treatment of hepatic veno-occlusive disease/sinusoidal obstruction syndrome.

    Science.gov (United States)

    Richardson, Paul G; Triplett, Brandon M; Ho, Vincent T; Chao, Nelson; Dignan, Fiona L; Maglio, Michelle; Mohty, Mohamad

    2018-02-01

    Hepatic veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is an unpredictable condition associated with endothelial-cell damage due to conditioning for hematopoietic stem-cell transplantation (HSCT) or chemotherapy without HSCT. Mortality in patients with VOD/SOS and multi-organ dysfunction (MOD) may be >80%. Areas covered: Defibrotide is the only approved drug for the treatment of severe hepatic VOD/SOS after HSCT in the European Union and hepatic VOD/SOS with renal or pulmonary dysfunction in the United States. Its efficacy in patients with VOD/SOS with MOD post-HSCT was demonstrated in a clinical-trial program that included a historically controlled treatment study, a phase 2 trial, and a large T-IND expanded-access program that also included patients without MOD and who received chemotherapy without HSCT. Expert commentary: Defibrotide appears to protect endothelial cells and restore the thrombolytic-fibrinolytic balance. It addresses a significant clinical need and has demonstrated favorable Day +100 survival and overall adverse-event rates that seem similar to control groups receiving supportive care alone. Currently, defibrotide is under investigation for the prevention of VOD/SOS in high-risk pediatric and adult patients.

  1. Safety and effects of prophylactic defibrotide for sinusoidal obstruction syndrome in hematopoietic stem cell transplantation.

    Science.gov (United States)

    Park, Meerim; Park, Hyeon Jin; Eom, Hyeon-Seok; Kwon, Young Joo; Park, Jeong A; Lim, Yeon Jung; Yoon, Jong Hyung; Kong, Sun-Young; Ghim, Thad T; Lee, Hye Won; Yun, Tak; Park, Byung-Kiu

    2013-01-28

    Sinusoidal obstruction syndrome (SOS) is a serious complication of hematopoietic stem cell transplantation (HSCT), with a mortality rate of up to 90%. We report our experience on the use of defibrotide for SOS prophylaxis in HSCT. We retrospectively reviewed data of 49 patients who received defibrotide as SOS prophylaxis during the course of HSCT at the National Cancer Center, Goyang, Korea, between August 2005 and July 2008. Thirty-four patients (69.4%) were classified as a high-risk group for developing SOS. Defibrotide was well-tolerated, without any grade 3 or 4 toxicity. The median value of maximum total bilirubin within 100 days after HSCT was within the normal range. SOS was diagnosed in only 1 patient, who underwent autologous HSCT due to relapsed medulloblastoma. There was no day 100 treatment-related mortality in our study. Defibrotide appears to be a safe prophylaxis for SOS. This study suggests that it could be effective to use prophylactic defibrotide in advance to improve HSCT outcomes in patients at risk of SOS.

  2. Successful treatment with defibrotide for sinusoidal obstruction syndrome after hematopoietic stem cell transplantation.

    Science.gov (United States)

    Yakushijin, Kimikazu; Matsui, Toshimitsu; Okamura, Atsuo; Yamamoto, Katsuya; Ito, Mitsuhiro; Chihara, Kazuo

    2005-01-01

    Sinusoidal obstruction syndrome (SOS) (formerly known as hepatic veno-occlusive disease (VOD)) is a life-threatening complication subsequent to hematopoietic stem cell transplantation. However, no completely satisfactory strategies for the treatment of SOS have been established yet. Defibrotide is a single-stranded polydeoxyribonucleotide with anti-thrombotic, anti-ischemic, anti-inflammatory and thrombolytic properties, but without systemic anticoagulant effects, and some encouraging results have been reported in western countries. We treated four patients with defibrotide for SOS, since there seemed to be no possibility to cure the patients with conventionally available treatments in Japan. All patients showed evidence of multiple organ failure at the start of the treatment. Defibrotide was administered intravenously in normal saline in four divided doses for 14 to 27 days. Three patients (75%) responded to the therapy, while one died of SOS and cytomegalovirus infection despite intensive therapy. None of the patients suffered from significant adverse effects such as severe hemorrhage. This is the first report dealing with the treatment with defibrotide of Japanese patients with SOS. Because defibrotide is considered to be promising for the treatment of SOS, it is important to start a phase II study as soon as possible.

  3. The Role of Thromboelastography in Pediatric Patients with Sinusoidal Obstructive Syndrome Receiving Defibrotide.

    Science.gov (United States)

    Gendreau, Joanna L; Knoll, Christine; Adams, Roberta H; Su, Leon L

    2017-04-01

    Sinusoidal obstructive syndrome (SOS) is a potentially fatal form of hepatic injury after hematopoietic stem cell transplantation. Patients can develop liver dysfunction, portal hypertension, ascites, coagulopathies, and multisystem organ failure. The mortality rate of severe SOS has been reported as high as 98% by day 100 after transplantation. Defibrotide, which is now approved for the treatment of SOS, has significantly decreased mortality. Defibrotide is a polynucleotide with profibrinolytic, anti-ischemic, and anti-inflammatory activity. These properties can increase the risk of life-threatening bleeding in this patient population. Previous protocols have suggested maintaining international normalized ratio ≤ 1.5, platelets > 30 k/uL, and fibrinogen ≥ 150 mg/dL to minimize this risk of bleeding. However, this can be challenging in fluid-sensitive patients with SOS. Thromboelastography (TEG) is a functional assay that evaluates the balance of procoagulant and anticoagulant proteins. In this series, TEG was used to guide defibrotide therapy as well as blood product transfusions in SOS patients with abnormal coagulation studies. Each patient recovered from SOS and had no bleeding complications. A randomized clinical trial is the next step in supporting the use of TEG in SOS patients with abnormal coagulation studies receiving defibrotide therapy. Copyright © 2017 The American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.

  4. Defibrotide for the treatment of sinusoidal obstruction syndrome: evaluation of response to therapy and patient outcomes.

    Science.gov (United States)

    Coutsouvelis, John; Avery, Sharon; Dooley, Michael; Kirkpatrick, Carl; Spencer, Andrew

    2018-03-01

    Defibrotide is an agent used to treat sinusoidal obstruction syndrome (SOS/VOD) in patients undergoing haemopoietic stem cell transplantation. The aim of this study was to evaluate the effectiveness of defibrotide used within institutional guidelines for the treatment of SOS/VOD in patients undergoing haemopoietic stem cell transplantation (HSCT). Data for 23 patients was retrospectively reviewed to evaluate the effectiveness of defibrotide and the utility of response criteria to direct therapy as specified within institution guidelines. Patients met institutional criteria for a diagnosis of SOS/VOD based on predominantly Baltimore criteria and received defibrotide. Stabilisation or improvement in symptoms and biochemical markers was required for continuation of therapy with defibrotide. Overall, 14 patients responded to therapy. Survival at day 100 post HSCT was 70%. Median serum (total) bilirubin concentrations in all evaluable patients had decreased at days 5 and 10 (p defibrotide, there was a decrease in the proportion of patients exhibiting hepatomegaly (p = 0.02), ascites (p Defibrotide to treat SOS/VOD and continued based on attainment of early response was effective management of this condition. Defibrotide should be considered in any consensus protocol providing guidance on the management of SOS/VOD, with future studies considered to assess appropriate time points for response to therapy during treatment.

  5. Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2 mediated regeneration of sinusoidal endothelial cells

    Science.gov (United States)

    Hooper, Andrea T.; Butler, Jason M.; Nolan, Daniel J; Kranz, Andrea; Iida, Kaoruko; Kobayashi, Mariko; Kopp, Hans-Georg; Shido, Koji; Petit, Isabelle; Yanger, Kilangsungla; James, Daylon; Witte, Larry; Zhu, Zhenping; Wu, Yan; Pytowski, Bronislaw; Rosenwaks, Zev; Mittal, Vivek; Sato, Thomas N.; Rafii, Shahin

    2011-01-01

    SUMMARY The phenotypic attributes and molecular determinants for the regeneration of bone marrow (BM) sinusoidal endothelial cells (SECs) and their contribution to hematopoiesis are unknown. We show that after myelosuppression VEGFR2 activation promotes reassembly of regressed SECs, reconstituting hematopoietic stem and progenitor cells (HSPCs). VEGFR2 and VEGFR3 expression are restricted to BM vasculature, demarcating a continuous network of VEGFR2+VEGFR3+Sca1− SECs and VEGFR2+VEGFR3−Sca1+ arterioles. While chemotherapy (5FU) and sublethal irradiation (650 rad) induce minor SEC regression, lethal irradiation (950 rad) induces severe regression of SECs requiring BM transplantation (BMT) for regeneration. Conditional deletion of VEGFR2 in adult mice blocks regeneration of SECs in sublethally irradiated animals, preventing hematopoietic reconstitution. Inhibition of VEGFR2 signaling in lethally irradiated wild type mice rescued with BMT severely impairs SEC reconstruction, preventing engraftment and reconstitution of HSPCs. Therefore, activation of VEGFR2 is critical for regeneration of VEGFR3+Sca1− SECs that are essential for engraftment and restoration of HSPCs and hematopoiesis. PMID:19265665

  6. Unsteady flow damping force prediction of MR dampers subjected to sinusoidal loading

    Science.gov (United States)

    Yu, M.; Wang, S. Q.; Fu, J.; Peng, Y. X.

    2013-02-01

    So far quasi-steady models are usually used to design magnetorheological (MR) dampers, but these models are not sufficient to describe the MR damper behavior under unsteady dynamic loading, for fluid inertia is neglected in quasi-steady models, which will bring more error between computer simulation and experimental results. Under unsteady flow model, the fluid inertia terms will bring error calculated upto 10%, so it is necessary to be considered in the governing equation. In this paper, force-stroke behavior of MR damper with flow mode due to sinusoidal loading excitation is mainly investigated, to simplify the analysis, the one-dimensional axisymmetric annular duct geometry of MR dampers is approximated as a rectangular duct. The rectangular duct can be divided into 3 regions for the velocity profile of the incompressible MR fluid flow, in each region, a partial differential equation is composed of by Navier-Stokes equations, boundary conditions and initial conditions to determine the velocity solution. In addition, in this work, not only Bingham plastic model but the Herschel—Bulkley model is adopted to analyze the MR damper performance. The damping force resulting from the pressure drop of unsteady MR dampers can be obtained and used to design or size MR dampers. Compared with the quasi-steady flow damping force, the damping force of unsteady MR dampers is more close to practice, particularly for the high-speed unsteady movement of MR dampers.

  7. Unsteady flow damping force prediction of MR dampers subjected to sinusoidal loading

    International Nuclear Information System (INIS)

    Yu, M; Fu, J; Wang, S Q; Peng, Y X

    2013-01-01

    So far quasi-steady models are usually used to design magnetorheological (MR) dampers, but these models are not sufficient to describe the MR damper behavior under unsteady dynamic loading, for fluid inertia is neglected in quasi-steady models, which will bring more error between computer simulation and experimental results. Under unsteady flow model, the fluid inertia terms will bring error calculated upto 10%, so it is necessary to be considered in the governing equation. In this paper, force-stroke behavior of MR damper with flow mode due to sinusoidal loading excitation is mainly investigated, to simplify the analysis, the one-dimensional axisymmetric annular duct geometry of MR dampers is approximated as a rectangular duct. The rectangular duct can be divided into 3 regions for the velocity profile of the incompressible MR fluid flow, in each region, a partial differential equation is composed of by Navier-Stokes equations, boundary conditions and initial conditions to determine the velocity solution. In addition, in this work, not only Bingham plastic model but the Herschel—Bulkley model is adopted to analyze the MR damper performance. The damping force resulting from the pressure drop of unsteady MR dampers can be obtained and used to design or size MR dampers. Compared with the quasi-steady flow damping force, the damping force of unsteady MR dampers is more close to practice, particularly for the high-speed unsteady movement of MR dampers.

  8. Improvement of stability of sinusoidally driven atmospheric pressure plasma jet using auxiliary bias voltage

    Directory of Open Access Journals (Sweden)

    Hyun-Jin Kim

    2015-12-01

    Full Text Available In this study, we have proposed the auxiliary bias pulse scheme to improve the stability of atmospheric pressure plasma jets driven by an AC sinusoidal waveform excitation source. The stability of discharges can be significantly improved by the compensation of irregular variation in memory voltage due to the effect of auxiliary bias pulse. From the parametric study, such as the width, voltage, and onset time of auxiliary bias pulse, it has been demonstrated that the auxiliary bias pulse plays a significant role in suppressing the irregular discharges caused by the irregular variation in memory voltage and stable discharge can be initiated with the termination of the auxiliary bias pulse. As a result of further investigating the effects of the auxiliary pulse scheme on the jet stability under various process conditions such as the distance between the jet head and the counter electrode, and carrier gas flow, the jet stability can be improved by adjusting the amplitude and number of the bias pulse depending on the variations in the process conditions.

  9. In-vitro study on haemodiluted blood flow in a sinusoidal microstenosis.

    Science.gov (United States)

    Kang, M J; Ji, H-S; Lee, S J

    2010-01-01

    In-vitro experiments were carried out to investigate the haemodynamic and haemorheological behaviours of haemodiluted blood flow through a microstenosis using a micro-particle image velocimetry (PIV) technique. The micro-PIV system employed in this study consisted of a two-head neodymium:yttrium-aluminium-garnet (Nd:YAG) laser, a cooled charge-coupled device camera, and a delay generator. To simulate blood flow in a stenosed vascular vessel, a polydimethylsiloxane (PDMS) microchannel with a sinusoidal throat of 80 per cent severity was employed. The width and depth of the microchannel were 100 microm and 50 microm, respectively. To compare the flow characteristics in the microstenosis, the same experiments were repeated in a straight microchannel under the same flow conditions. Using a syringe pump, human blood with 5 per cent haematocrit was supplied into the microstenosis channel. The flow characteristics and transport of blood cells through the microstenosis were investigated with various flowrates. The mean velocity fields were nearly symmetric with respect to the channel centreline. In the contraction section, the oncoming blood flow was accelerated rapidly, and the maximum velocity at the throat was almost 4.99 times faster than that of the straight microchannel without stenosis. In the diffusion section, the blood cells show rolling, deformation, twisting, and tumbling motion due to the flow-choking characteristics at the stenotic region. The results from this study will provide useful basic data for comparison with those obtained by clinical researchers.

  10. Effects of chronic alcoholism in the sensitivity to luminance contrast in vertical sinusoidal gratings

    Directory of Open Access Journals (Sweden)

    Éllen Dias Nicácio da Cruz

    2016-01-01

    Full Text Available Abstract The aim of this study was to measure visual contrast sensitivity (CS of luminance using vertical sinusoidal gratings with spatial frequencies of 0.6, 2.5, 5.0 and 20.0 cycles per degree of visual angle in chronic alcoholics in abstinence period. The participants were 20 volunteers (26–59 years of age divided into two groups: the study group (SG consisted of 10 volunteers with a clinical history of chronic alcoholism abstinence and the control group (CG consisted of 10 healthy volunteers. Each group had five female and five male participants. All participants had normal or corrected visual acuity and were free of identifiable diseases. The psychophysical method of forced choice between two temporal alternatives (2AFC was used to measure visual CS of luminance of 41.2 cd/m2. The results showed significant differences between groups for all spatial frequencies tested (p< 0.001. These results suggest alterations in the visual perception related to chronic alcohol consumption even after years of abstinence.

  11. Investigation of secondary flows in turbulent pipe flows with three-dimensional sinusoidal walls

    Science.gov (United States)

    Chan, Leon; MacDonald, Michael; Chung, Daniel; Hutchins, Nicholas; Ooi, Andrew

    2017-11-01

    The occurrence of secondary flows is systematically investigated via Direct Numerical Simulations (DNS) of turbulent flow in a rough wall pipe at friction Reynolds numbers of 540. In this study, the peak-to-trough height of the roughness elements, which consist of three-dimensional sinusoidal roughness, is fixed at 120 viscous units while the wavelength of the roughness elements is varied. The solidity or effective slope (ES) of the roughness ranges from the sparse regime (ES = 0.18) to the closely packed roughness/dense regime (ES = 0.72). The time-independent dispersive stresses, which arise due to the stationary features of the flow, are analysed and are found to increase with increasing roughness wavelength. These dispersive stresses are related to the occurrence of secondary flows and are maximum within the roughness canopy. Above the crest of the roughness elements, the dispersive stresses reduce to zero at wall-normal heights greater than half of the roughness wavelength. This study has found that the size and wall-normal extent of the secondary flows scales with the roughness wavelength and can reach wall-normal heights of almost half of the pipe radius.

  12. Overview of PHARE projects implemented in Romania between 1997 and 2008 for enhancing the nuclear safety level

    Energy Technology Data Exchange (ETDEWEB)

    Sanda, Radian; Zerger, Benoit; Manna, Giustino; Farrar, Brian [European Commission, Petten (Netherlands). Joint Research Centre (JRC)

    2015-01-15

    Through the Poland Hungary Aid for Reconstruction of the Economy (PHARE) programme, the European Commission (EC) supported the transition of the Eastern European states to the European market economy. PHARE was a pre-accession financial assistance programme which involved countries from Central and Eastern Europe that applied to become members of the European Union. The paper presents a synthesis of the projects carried out in Romania for enhancing nuclear safety by consolidating key areas such as Regulatory Activities, Radioactive Waste Management and On-Site assistance, in order to fulfil the requirements for accession to the European Union. Statistical considerations on the impact of the projects are also proposed and an analysis of the methodology of intervention is made.

  13. Improving Transfer of Learning: An Innovative Comentoring Program to Enhance Workplace Implementation After an Occupational Therapy Course on Autism Spectrum Disorders.

    Science.gov (United States)

    Ashburner, Jill; Ziviani, Jenny; Rodger, Sylvia; Hinder, Elizabeth A; Cartmill, Linda; White, Jessica; Vickerstaff, Sandy

    2015-01-01

    Research suggests that learning gained through training is infrequently implemented in the workplace. A short-term postcourse comentoring program was developed with the aim of facilitating workplace implementation of learning after a 3-day course for occupational therapists. The program was evaluated for usefulness, successes, challenges, recommended improvements, and associations with changes in self-rated knowledge and confidence. Two months after the course, 42 participants completed an evaluation of the comentoring program with closed- and open-ended questions addressing usefulness, successes, challenges, pairing preferences, and recommendations. They also completed a record on whether or not they had worked on goals nominated in their comentoring contract. Before and 2 months after the course, they completed a self-rated questionnaire on knowledge and confidence. The comentoring program was recommended by 80% of participants. Benefits included opportunities for information and resource sharing, debriefing, problem solving, reassurance, and implementation of ideas. Ninety-five percent of participants worked on some or all their comentoring goals. Although there were significant improvements in knowledge (P < 0.001) and confidence (P < 0.001), the total comentoring evaluation score was not significantly associated with these changes. It is therefore possible that these improvements related to the course itself rather than the comentoring program. Challenges related to time, scheduling, distance, and pairing of comentors. Reported benefits of the program included enhanced psychosocial support and prompting to trial newly learned strategies. Effectiveness may be improved by setting aside time for comentoring in the workplace and better matching of comentors.

  14. Quantitative Myocardial Perfusion with Dynamic Contrast-Enhanced Imaging in MRI and CT: Theoretical Models and Current Implementation

    Directory of Open Access Journals (Sweden)

    G. J. Pelgrim

    2016-01-01

    Full Text Available Technological advances in magnetic resonance imaging (MRI and computed tomography (CT, including higher spatial and temporal resolution, have made the prospect of performing absolute myocardial perfusion quantification possible, previously only achievable with positron emission tomography (PET. This could facilitate integration of myocardial perfusion biomarkers into the current workup for coronary artery disease (CAD, as MRI and CT systems are more widely available than PET scanners. Cardiac PET scanning remains expensive and is restricted by the requirement of a nearby cyclotron. Clinical evidence is needed to demonstrate that MRI and CT have similar accuracy for myocardial perfusion quantification as PET. However, lack of standardization of acquisition protocols and tracer kinetic model selection complicates comparison between different studies and modalities. The aim of this overview is to provide insight into the different tracer kinetic models for quantitative myocardial perfusion analysis and to address typical implementation issues in MRI and CT. We compare different models based on their theoretical derivations and present the respective consequences for MRI and CT acquisition parameters, highlighting the interplay between tracer kinetic modeling and acquisition settings.

  15. Effect of photonic crystal and frequency selective surface implementation on gain enhancement in the microstrip patch antenna at terahertz frequency

    Energy Technology Data Exchange (ETDEWEB)

    Nejati, Ameneh, E-mail: ameneh.nejati@gmail.com [Department of Electrical Engineering, Science and Research Branch, Islamic Azad University, Tehran (Iran, Islamic Republic of); Sadeghzadeh, Ramezan Ali [Faculty of Electrical and Computer Engineering, K.N Toosi University of Technology, Tehran (Iran, Islamic Republic of); Geran, Fatemeh [Faculty of Electrical and Computer Engineering, Shahid Rajaee Teacher Training University, Tehran (Iran, Islamic Republic of)

    2014-09-15

    In this paper, microstrip patch antenna with frequency selective surface (FSS) and photonic band gap (PBG) structures in the frequency range of 0.5–0.7 THz is presented for wireless communications. Proposed patch antenna is designed on a substrate with uniform and non-uniform PBG structures. Here, the effects of substrate thickness, various radii and arrangement of holes on antenna resonance in both PBG forms are studied. Near zero characteristic on uniform and non-uniform PBG substrate is compared and the results show that along with increase in hole radius, antenna operating frequency and bandwidth are increased. Also, the FSS structure is designed as a perfect absorber. Finally, by using FSS and PBG structures simultaneously, gain enhancement, increase in directivity and pattern shaping are studied at THz field. The antenna gain in final structure is increased by 2 dBi (32%) in comparison to simple form and Half-Power beam width is reduced from 100°×80° in simple form to 72°×48° by using FSS and PBG. All simulations and designs are done by Ansoft HFSS and CST Microwave Studio simulation tools with different full wave methods.

  16. Activities of the Oil Implementation Task Force, reporting period March--August 1991; Contracts for field projects and supporting research on enhanced oil recovery, reporting period October--December 1990

    Energy Technology Data Exchange (ETDEWEB)

    1991-10-01

    Activities of DOE's Oil Implementation Task Force for the period March--August 1991 are reviewed. Contracts for fields projects and supporting research on enhanced oil recovery are discussed, with a list of related publications given. Enhanced recovery processes covered include chemical flooding, gas displacement, thermal recovery, and microbial recovery.

  17. Enhancing the emergency department approach to pediatric sexual assault care: implementation of a pediatric sexual assault response team program.

    Science.gov (United States)

    Goyal, Monika K; Mollen, Cynthia J; Hayes, Katie L; Molnar, Jennifer; Christian, Cindy W; Scribano, Philip V; Lavelle, Jane

    2013-09-01

    The objectives of this study were to describe the experience of a novel pediatric sexual assault response team (SART) program in the first 3 years of implementation and compare patient characteristics, evaluation, and treatment among subpopulations of patients. This was a retrospective chart review of a consecutive sample of patients evaluated at a pediatric emergency department (ED) who met institutional criteria for a SART evaluation. Associations of evaluation and treatment with sex, menarchal status, and presence of injuries were measured using logistic regression. One hundred eighty-four patients met criteria for SART evaluation, of whom 87.5% were female; mean age was 10.1 (SD, 4.6) years. The majority of patients underwent forensic evidence collection (89.1%), which varied by menarchal status among girls (P < 0.01), but not by sex. Evidence of acute anogenital injury on physical examination was found in 20.6% of patients. As per the Centers for Disease Control and Prevention guidelines for acute sexual assault evaluations in pediatric patients, menarchal girls were more likely to undergo testing for sexually transmitted infections and pregnancy (P < 0.01) and to be offered pregnancy, sexually transmitted infection, and HIV prophylaxis (P < 0.01). In an effort to improve quality and consistency of acute sexual assault examinations in a pediatric ED, development of a SART program supported the majority of eligible patients undergoing forensic evidence collection. Furthermore, a substantial number of patients had evidence of injury on examination. These findings underscore the importance of having properly trained personnel to support ED care for pediatric victims of acute sexual assault.

  18. The electronic states calculated using the sinusoidal potential for Cd1-xZnxS quantum dot superlattices

    International Nuclear Information System (INIS)

    Sakly, A.; Safta, N.; Mejri, H.; Lamine, A. Ben

    2011-01-01

    Research highlights: → This paper is dedicated to structures based on Cd 1-x Zn x S. - Abstract: The present work reports on a theoretical investigation of superlattices based on Cd 1-x Zn x S quantum dots embedded in an insulating material. The system to model is assumed to be a series of flattened cylindrical quantum dots with a finite barrier at the boundary and is studied using a sinusoidal potential. The electronic states of both Γ 1 - (ground) and Γ 2 - (first excited) minibands have been computed as a function of inter-quantum dot separation and Zn composition. An analysis of the results shows that the widths of Γ 1 - and Γ 2 - minibands decrease as the superlattice period and Zn content increase separately. Moreover, the sinusoidal shape of the confining potential accounts for the coupling between quantum dots quantitatively less than the Kronig-Penney potential model.

  19. An all digital phase locked loop for synchronization of a sinusoidal signal embedded in white Gaussian noise

    Science.gov (United States)

    Reddy, C. P.; Gupta, S. C.

    1973-01-01

    An all digital phase locked loop which tracks the phase of the incoming sinusoidal signal once per carrier cycle is proposed. The different elements and their functions and the phase lock operation are explained in detail. The nonlinear difference equations which govern the operation of the digital loop when the incoming signal is embedded in white Gaussian noise are derived, and a suitable model is specified. The performance of the digital loop is considered for the synchronization of a sinusoidal signal. For this, the noise term is suitably modelled which allows specification of the output probabilities for the two level quantizer in the loop at any given phase error. The loop filter considered increases the probability of proper phase correction. The phase error states in modulo two-pi forms a finite state Markov chain which enables the calculation of steady state probabilities, RMS phase error, transient response and mean time for cycle skipping.

  20. SU-E-T-468: Implementation of the TG-142 QA Process for Seven Linacs with Enhanced Beam Conformance

    Energy Technology Data Exchange (ETDEWEB)

    Woollard, J; Ayan, A; DiCostanzo, D; Grzetic, S; Hessler, J; Gupta, N [OH State University, Columbus, OH (United States)

    2015-06-15

    Purpose: To develop a TG-142 compliant QA process for 7 Varian TrueBeam linear accelerators (linacs) with enhanced beam conformance and dosimetrically matched beam models. To ensure consistent performance of all 7 linacs, the QA process should include a common set of baseline values for use in routine QA on all linacs. Methods: The TG 142 report provides recommended tests, tolerances and frequencies for quality assurance of medical accelerators. Based on the guidance provided in the report, measurement tests were developed to evaluate each of the applicable parameters listed for daily, monthly and annual QA. These tests were then performed on each of our 7 new linacs as they came on line at our institution. Results: The tolerance values specified in TG-142 for each QA test are either absolute tolerances (i.e. ±2mm) or require a comparison to a baseline value. The results of our QA tests were first used to ensure that all 7 linacs were operating within the suggested tolerance values provided in TG −142 for those tests with absolute tolerances and that the performance of the linacs was adequately matched. The QA test results were then used to develop a set of common baseline values for those QA tests that require comparison to a baseline value at routine monthly and annual QA. The procedures and baseline values were incorporated into a spreadsheets for use in monthly and annual QA. Conclusion: We have developed a set of procedures for daily, monthly and annual QA of our linacs that are consistent with the TG-142 report. A common set of baseline values was developed for routine QA tests. The use of this common set of baseline values for comparison at monthly and annual QA will ensure consistent performance of all 7 linacs.

  1. SU-E-T-468: Implementation of the TG-142 QA Process for Seven Linacs with Enhanced Beam Conformance

    International Nuclear Information System (INIS)

    Woollard, J; Ayan, A; DiCostanzo, D; Grzetic, S; Hessler, J; Gupta, N

    2015-01-01

    Purpose: To develop a TG-142 compliant QA process for 7 Varian TrueBeam linear accelerators (linacs) with enhanced beam conformance and dosimetrically matched beam models. To ensure consistent performance of all 7 linacs, the QA process should include a common set of baseline values for use in routine QA on all linacs. Methods: The TG 142 report provides recommended tests, tolerances and frequencies for quality assurance of medical accelerators. Based on the guidance provided in the report, measurement tests were developed to evaluate each of the applicable parameters listed for daily, monthly and annual QA. These tests were then performed on each of our 7 new linacs as they came on line at our institution. Results: The tolerance values specified in TG-142 for each QA test are either absolute tolerances (i.e. ±2mm) or require a comparison to a baseline value. The results of our QA tests were first used to ensure that all 7 linacs were operating within the suggested tolerance values provided in TG −142 for those tests with absolute tolerances and that the performance of the linacs was adequately matched. The QA test results were then used to develop a set of common baseline values for those QA tests that require comparison to a baseline value at routine monthly and annual QA. The procedures and baseline values were incorporated into a spreadsheets for use in monthly and annual QA. Conclusion: We have developed a set of procedures for daily, monthly and annual QA of our linacs that are consistent with the TG-142 report. A common set of baseline values was developed for routine QA tests. The use of this common set of baseline values for comparison at monthly and annual QA will ensure consistent performance of all 7 linacs

  2. Comparison of linear and nonlinear implementation of the compartmental tissue uptake model for dynamic contrast-enhanced MRI.

    Science.gov (United States)

    Kallehauge, Jesper F; Sourbron, Steven; Irving, Benjamin; Tanderup, Kari; Schnabel, Julia A; Chappell, Michael A

    2017-06-01

    Fitting tracer kinetic models using linear methods is much faster than using their nonlinear counterparts, although this comes often at the expense of reduced accuracy and precision. The aim of this study was to derive and compare the performance of the linear compartmental tissue uptake (CTU) model with its nonlinear version with respect to their percentage error and precision. The linear and nonlinear CTU models were initially compared using simulations with varying noise and temporal sampling. Subsequently, the clinical applicability of the linear model was demonstrated on 14 patients with locally advanced cervical cancer examined with dynamic contrast-enhanced magnetic resonance imaging. Simulations revealed equal percentage error and precision when noise was within clinical achievable ranges (contrast-to-noise ratio >10). The linear method was significantly faster than the nonlinear method, with a minimum speedup of around 230 across all tested sampling rates. Clinical analysis revealed that parameters estimated using the linear and nonlinear CTU model were highly correlated (ρ ≥ 0.95). The linear CTU model is computationally more efficient and more stable against temporal downsampling, whereas the nonlinear method is more robust to variations in noise. The two methods may be used interchangeably within clinical achievable ranges of temporal sampling and noise. Magn Reson Med 77:2414-2423, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.

  3. Construction of a liver sinusoid based on the laminar flow on chip and self-assembly of endothelial cells.

    Science.gov (United States)

    Mi, Shengli; Yi, Xiaoman; Du, Zhichang; Xu, Yuanyuan; Sun, Wei

    2018-02-20

    The liver is one of the main metabolic organs, and nearly all ingested drugs will be metabolized by the liver. Only a small fraction of drugs are able to come onto the market during drug development, and hepatic toxicity is a major cause for drug failure. Since drug development is costly in both time and materials, an in vitro liver model that can accelerate bioreactions in the liver and reduce drug consumption is imperative in the pharmaceutical industry. The liver on a chip is an ideal alternative for its controllable environment and tiny size, which means constructing a more biomimetic model, reducing material consumption as well as promoting drug diffusion and reaction. In this study, taking advantage of the laminar flow on chips and using natural degradable gel rat tail Collagen-I, we constructed a liver sinusoid on a chip. By synchronously injecting two kinds of cell-laden collagen, HepG2-laden collagen and HUVEC-laden collagen, we formed two collagen layers with a clear borderline. By controlling the HUVEC density and injection of growth factors, HUVECs in collagen formed a monolayer through self-assembly. Thus, a liver sinusoid on a chip was achieved in a more biomimetic environment with a more controllable and uniform distribution of discrete HUVECs. Viability, album secretion and urea synthesis of the live sinusoid on a chip were analysed on days 3, 5 and 7 after collagen injection with acetaminophen treatment at 0 (control), 10 and 20 mM. The results indicated that our liver sinusoid on a chip was able to maintain bioactivity and function for at least 7 d and was beneficial for hepatotoxic drug screening.

  4. Large right ventricular sinusoids in an infant with aorta-left ventricular tunnel and proximal right coronary artery atresia.

    Science.gov (United States)

    Chen, Peter C; Spinner, Joseph A; Heinle, Jeffrey S

    2018-07-01

    We report a 1-month-old infant diagnosed with an aorta-left ventricular tunnel, ventricular septal defect, and right coronary atresia with right ventricular sinusoids. The patient's anatomy and physiology did not indicate right-ventricular-dependent coronary circulation, and therefore right ventricular decompression could be performed without compromising coronary perfusion during surgical correction. A detailed understanding of the coronary anatomy is critical in managing this defect when coronary anomalies are present.

  5. Additional Energy Losses from Asymmetric and Non-Sinusoidal Current in an Electrical Facility and Methods of their Reduction

    Directory of Open Access Journals (Sweden)

    Tarasov Evgeniy V.

    2015-01-01

    Full Text Available Influence of the asymmetry and higher harmonics of current on the operation of an electrical facility is analyzed. The level of additional losses from the asymmetric and non-sinusoidal currents is evaluated for a 110 kV electrical network in the Siberian Region of the Russian Federation. Methods for reducing the additional energy losses in the electrical facility are suggested.

  6. Sinusoidal oscillators with lower gain requirements at higher frequencies based on an explicit tanh(x) nonlinearity

    KAUST Repository

    Elwakil, Ahmed S.

    2009-04-28

    Two novel sinusoidal oscillator structures with an explicit tanh(x) nonlinearity are proposed. The oscillators have the attractive feature: the higher the operating frequency, the lower the necessary gain required to start oscillations. A nonlinear model for the two oscillators is derived and verified numerically. Spice simulations using AMS BiCMOS 0.35 μ model parameters and experimental results are shown. Copyright © 2009 John Wiley & Sons, Ltd.

  7. Interrogation of transcriptomic changes associated with drug-induced hepatic sinusoidal dilatation in colorectal cancer.

    Science.gov (United States)

    Jarzabek, Monika A; Proctor, William R; Vogt, Jennifer; Desai, Rupal; Dicker, Patrick; Cain, Gary; Raja, Rajiv; Brodbeck, Jens; Stevens, Dale; van der Stok, Eric P; Martens, John W M; Verhoef, Cornelis; Hegde, Priti S; Byrne, Annette T; Tarrant, Jacqueline M

    2018-01-01

    Drug-related sinusoidal dilatation (SD) is a common form of hepatotoxicity associated with oxaliplatin-based chemotherapy used prior to resection of colorectal liver metastases (CRLM). Recently, hepatic SD has also been associated with anti-delta like 4 (DLL4) cancer therapies targeting the NOTCH pathway. To investigate the hypothesis that NOTCH signaling plays an important role in drug-induced SD, gene expression changes were examined in livers from anti-DLL4 and oxaliplatin-induced SD in non-human primate (NHP) and patients, respectively. Putative mechanistic biomarkers of bevacizumab (bev)-mediated protection against oxaliplatin-induced SD were also investigated. RNA was extracted from whole liver sections or centrilobular regions by laser-capture microdissection (LCM) obtained from NHP administered anti-DLL4 fragment antigen-binding (F(ab')2 or patients with CRLM receiving oxaliplatin-based chemotherapy with or without bev. mRNA expression was quantified using high-throughput real-time quantitative PCR. Significance analysis was used to identify genes with differential expression patterns (false discovery rate (FDR) < 0.05). Eleven (CCL2, CCND1, EFNB2, ERG, ICAM1, IL16, LFNG, NOTCH1, NOTCH4, PRDX1, and TGFB1) and six (CDH5, EFNB2, HES1, IL16, MIK67, HES1 and VWF) candidate genes were differentially expressed in the liver of anti-DLL4- and oxaliplatin-induced SD, respectively. Addition of bev to oxaliplatin-based chemotherapy resulted in differential changes in hepatic CDH5, HEY1, IL16, JAG1, MMP9, NOTCH4 and TIMP1 expression. This work implicates NOTCH and IL16 pathways in the pathogenesis of drug-induced SD and further explains the hepato-protective effect of bev in oxaliplatin-induced SD observed in CRLM patients.

  8. Removing damped sinusoidal vibrations in adaptive optics systems using a DFT-based estimation method

    Science.gov (United States)

    Kania, Dariusz

    2017-06-01

    The problem of a vibrations rejection in adaptive optics systems is still present in publications. These undesirable signals emerge because of shaking the system structure, the tracking process, etc., and they usually are damped sinusoidal signals. There are some mechanical solutions to reduce the signals but they are not very effective. One of software solutions are very popular adaptive methods. An AVC (Adaptive Vibration Cancellation) method has been presented and developed in recent years. The method is based on the estimation of three vibrations parameters and values of frequency, amplitude and phase are essential to produce and adjust a proper signal to reduce or eliminate vibrations signals. This paper presents a fast (below 10 ms) and accurate estimation method of frequency, amplitude and phase of a multifrequency signal that can be used in the AVC method to increase the AO system performance. The method accuracy depends on several parameters: CiR - number of signal periods in a measurement window, N - number of samples in the FFT procedure, H - time window order, SNR, THD, b - number of A/D converter bits in a real time system, γ - the damping ratio of the tested signal, φ - the phase of the tested signal. Systematic errors increase when N, CiR, H decrease and when γ increases. The value of systematic error for γ = 0.1%, CiR = 1.1 and N = 32 is approximately 10^-4 Hz/Hz. This paper focuses on systematic errors of and effect of the signal phase and values of γ on the results.

  9. Dynamical pattern formation in a low-concentration magnetorheological fluid under two orthogonal sinusoidal fields

    International Nuclear Information System (INIS)

    Yépez, L.D.; Carrillo, J.L.; Donado, F.; Sausedo-Solorio, J.M.; Miranda-Romagnoli, P.

    2016-01-01

    The dynamical pattern formation of clusters of magnetic particles in a low-concentration magnetorheological fluid, under the influence of a superposition of two perpendicular sinusoidal fields, is studied experimentally. By varying the frequency and phase shift of the perpendicular fields, this configuration enables us to experimentally analyze a wide range of field configurations, including the case of a pure rotating field and the case of an oscillating unidirectional field. The fields are applied parallel to the horizontal plane where the fluid lies or in the vertical plane. For fields applied in the horizontal plane, we observed that, when the ratio of the frequencies increases, the average cluster size exhibits a kind of periodic resonances. When the phase shift between the fields is varied, the average chain length reaches maximal values for the cases of the rotating field and the unidirectional case. We analyze and discuss these results in terms of a weighted average of the time-dependent Mason number. In the case of a rotating field on the vertical plane, we also observe that the competition between the magnetic and the viscous forces determines the average cluster size. We show that this configuration generates a series of physically meaningful self-organization of clusters and transport phenomena. - Highlights: • A weighted average of the time-dependent Mason number is proposed. • The self-propelling clusters appear when a vertical rotating magnetic field is applied. • The largest average chain lengths are reached when frequencies are multiples one another. • Rotating and unidirectional alternating fields produce the largest average chain length values.

  10. Dynamical pattern formation in a low-concentration magnetorheological fluid under two orthogonal sinusoidal fields

    Energy Technology Data Exchange (ETDEWEB)

    Yépez, L.D.; Carrillo, J.L. [Instituto de Física de la Universidad Autónoma de Puebla, Ciudad Universitaria, Edif. 110 A, Puebla 72570 (Mexico); Donado, F.; Sausedo-Solorio, J.M.; Miranda-Romagnoli, P. [Instituto de Ciencias Básicas e Ingeniería Universidad Autónoma del Estado de Hidalgo, Pachuca 42090, Pachuca (Mexico)

    2016-06-15

    The dynamical pattern formation of clusters of magnetic particles in a low-concentration magnetorheological fluid, under the influence of a superposition of two perpendicular sinusoidal fields, is studied experimentally. By varying the frequency and phase shift of the perpendicular fields, this configuration enables us to experimentally analyze a wide range of field configurations, including the case of a pure rotating field and the case of an oscillating unidirectional field. The fields are applied parallel to the horizontal plane where the fluid lies or in the vertical plane. For fields applied in the horizontal plane, we observed that, when the ratio of the frequencies increases, the average cluster size exhibits a kind of periodic resonances. When the phase shift between the fields is varied, the average chain length reaches maximal values for the cases of the rotating field and the unidirectional case. We analyze and discuss these results in terms of a weighted average of the time-dependent Mason number. In the case of a rotating field on the vertical plane, we also observe that the competition between the magnetic and the viscous forces determines the average cluster size. We show that this configuration generates a series of physically meaningful self-organization of clusters and transport phenomena. - Highlights: • A weighted average of the time-dependent Mason number is proposed. • The self-propelling clusters appear when a vertical rotating magnetic field is applied. • The largest average chain lengths are reached when frequencies are multiples one another. • Rotating and unidirectional alternating fields produce the largest average chain length values.

  11. Gemtuzumab ozogamicin-induced sinusoidal obstructive syndrome treated with defibrotide: a case report.

    Science.gov (United States)

    Lannoy, D; Decaudin, B; Grozieux de Laguérenne, A; Barrier, F; Pignon, J M; Wetterwald, M; Odou, P

    2006-08-01

    New treatments for relapse of acute myeloid leukaemia (AML), include gemtuzumab ozogamicin (GO), an anti-CD33 monoclonal antibody. We describe a second case of GO-induced sinusoidal obstructive syndrome (SOS) effectively treated with defibrotide (DF). No stem-cell transplantation was involved. On day 23 after the first GO dose, a patient presented with ascites, weight gain, liver enlargement and pain in the right upper quadrant. Sudden hepatic cytolysis (transaminases at six times the normal range: grade 3) and cholestasis [alkaline phosphatase ALP and gamma-glutamyltransferase (GGT) respectively at four and eight times the normal range: grade 2] were observed but there was no evidence of increase serum bilirubin. Treatment with DF (Prociclide), Crinos; 10 mg/kg/day, or 200 mg, q.i.d.) improved the hepatic abnormality within a few days (serum transaminases decreased from 312 to 103 IU/L for aspartate aminotransferase (AST) and from 141 to 80 IU/L for alanine aminotransferase (ALT) within 3 days ALP increased from 253 to 383 IU/L and gamma-GT from 238 to 417 IU/L 4 days after administration of DF. The clinical and biological features of our case suggest a direct involvement of GO in causing SOS, even when used as monotherapy, without allogenic stem-cell transplantation. Low dose DF (10 mg/kg/day) given early during the development of SOS associated with GO was effective. Unfortunately, in our case the patient eventually died of multi-organ failure probably because of failure of GO.

  12. Defibrotide for the management of sinusoidal obstruction syndrome in patients who undergo haemopoietic stem cell transplantation.

    Science.gov (United States)

    Coutsouvelis, John; Avery, Sharon; Dooley, Michael; Kirkpatrick, Carl; Spencer, Andrew

    2016-11-01

    Sinusoidal obstruction syndrome, previously known as veno-occlusive disease (VOD/SOS), is a complication in patients undergoing haemopoietic stem cell transplantation (HSCT). Severe VOD/SOS, including progression to multi-organ failure, has resulted in a mortality of greater than 80%. Defibrotide's varying pharmacological actions, particularly on endothelial cells, make it is a useful agent to consider for prophylaxis and treatment of VOD/SOS. Barriers to its routine use include the high acquisition cost and the fact that neither the oral or parenteral formulations are licensed products in many countries at this time. This review summarises available literature on the use of defibrotide in the management of VOD/SOS. Publications consist predominantly of single centre cohort studies and case series. Available evidence indicates that defibrotide is effective in the management of VOD/SOS. Using defibrotide prophylaxis should also be considered, especially in the paediatric setting, where there are available results from a large, open label, randomized controlled trial. Patient outcome data from the larger studies and compassionate programs can inform consensus recommendations on dosing regimen and criteria for the treatment of VOD/SOS with defibrotide in the adult population. The reviewed literature indicates an effective and safe dose for treatment is 25mg/kg/day, continued for at least 14days or until complete response is achieved. Further studies are required to determine the optimal dose and duration of treatment in both paediatric patients and adults. Recent recommendations and a phase 3 trial using historical controls indicate that defibrotide should be included as a pharmacotherapy option in protocols guiding management of VOD/SOS. Copyright © 2016 Elsevier Ltd. All rights reserved.

  13. Treatment of sinusoidal obstruction syndrome with defibrotide: a single-center experience.

    Science.gov (United States)

    Sucak, G T; Aki, Z S; Yagcí, M; Yegin, Z A; Ozkurt, Z N; Haznedar, R

    2007-06-01

    Sinusoidal obstruction syndrome (SOS) is a frequent, troubling, and potentially fatal complication of hematopoietic stem cell transplantation. Despite promising results with defibrotide (DF), no treatment has been established as standard. DF is a single-stranded polydeoxyribonucleotide, obtained from controlled depolymerization of porcine intestinal mucosal cells. It has antithrombotic, antiischemic, antiinflammatory, and thrombolytic properties without significant side effects. We retrospectively evaluated the charts of 80 consecutive patients, with 89 hematopoietic stem cell transplants for hematologic malignancies. The results of early initiation of DF treatment in 14 patients with SOS are presented in this study. Fourteen patients, 8 males and 6 females % median age 40.5 years (range, 16-46 years) were diagnosed to have SOS. Disease severity was classified as severe in 6 (42.85%), moderate in 4 (28.57%), and mild in 4 (28.57%) patients. We treated 14 patients with DF for a median of 21.5 days (range, 4-39 days). All 14 patients received DF after the diagnosis of SOS. Three patients with severe and all of the patients with mild to moderate SOS responded to treatment with complete resolution of SOS-related signs and symptoms. All patients responding to DF were alive at 100 days posttransplantation. There was no significant drug-related side effect among patients treated with DF. With an overall response rate of 78.56% and a 50% complete response rate in severe SOS cases and minimal side effects, we suggest that DF is the best available agent to treat SOS.

  14. Sinusoidal Obstruction Syndrome during Treatment for Wilms' Tumor: A Life-threatening Complication

    Science.gov (United States)

    Totadri, Sidharth; Trehan, Amita; Bansal, Deepak; Jain, Richa

    2017-01-01

    Context: Survival rates exceed 90% in Wilms' tumor (WT). Actinomycin-D (ACT-D) which is indispensable in the management of WT is associated with the development of sinusoidal obstruction syndrome (SOS), a potentially fatal complication. Aims: The aim is to study the presentation, management, and outcome of SOS complicating ACT-D administration in WT. Settings and Design: Retrospective file review conducted in a Pediatric Hematology-Oncology unit. Materials and Methods: Patients diagnosed and treated for WT from January 2012 to December 2015 were analyzed. SOS was diagnosed clinically, based on McDonalds criteria, requiring two of the following: jaundice, hepatomegaly and/or right upper quadrant pain, weight gain with or without ascites. Results: Of 104 patients treated, SOS occurred in 5 (4.8%). Age: 6 months to 5 years, 3 were girls. Tumor involved left kidney in 3, right in 1 and a horseshoe kidney in 1. Histopathology was consistent with WT in 4 and clear cell sarcoma kidney in 1. One had pulmonary metastases. Three developed SOS preoperatively and two during adjuvant chemotherapy. None received radiotherapy. Clinical manifestations comprised of jaundice, hepatomegaly, ascites/weight gain, respiratory distress, hypotension, and encephalopathy. Laboratory findings included thrombocytopenia, elevated serum transaminases, and coagulopathy. Treatment included fluid restriction, broad spectrum antibiotics, and transfusional support. Two children received N-acetyl cysteine infusion. Defibrotide was administered to two patients. Four recovered and one succumbed to multi-organ failure. Two patients were safely re-challenged with 50% doses of ACT-D. Conclusions: SOS is a clinical diagnosis. Systematic supportive care can enable complete recovery. Under close monitoring, re-challenge of ACT-D can be performed in gradually escalating doses. PMID:29333010

  15. First evidence of pyrrolizidine alkaloid N-oxide-induced hepatic sinusoidal obstruction syndrome in humans.

    Science.gov (United States)

    Yang, Mengbi; Ruan, Jianqing; Gao, Hong; Li, Na; Ma, Jiang; Xue, Junyi; Ye, Yang; Fu, Peter Pi-Cheng; Wang, Jiyao; Lin, Ge

    2017-12-01

    Pyrrolizidine alkaloids (PAs) are among the most potent phytotoxins widely distributed in plant species around the world. PA is one of the major causes responsible for the development of hepatic sinusoidal obstruction syndrome (HSOS) and exerts hepatotoxicity via metabolic activation to form the reactive metabolites, which bind with cellular proteins to generate pyrrole-protein adducts, leading to hepatotoxicity. PA N-oxides coexist with their corresponding PAs in plants with varied quantities, sometimes even higher than that of PAs, but the toxicity of PA N-oxides remains unclear. The current study unequivocally identified PA N-oxides as the sole or predominant form of PAs in 18 Gynura segetum herbal samples ingested by patients with liver damage. For the first time, PA N-oxides were recorded to induce HSOS in human. PA N-oxide-induced hepatotoxicity was further confirmed on mice orally dosed of herbal extract containing 170 μmol PA N-oxides/kg/day, with its hepatotoxicity similar to but potency much lower than the corresponding PAs. Furthermore, toxicokinetic study after a single oral dose of senecionine N-oxide (55 μmol/kg) on rats revealed the toxic mechanism that PA N-oxides induced hepatotoxicity via their biotransformation to the corresponding PAs followed by the metabolic activation to form pyrrole-protein adducts. The remarkable differences in toxicokinetic profiles of PAs and PA N-oxides were found and attributed to their significantly different hepatotoxic potency. The findings of PA N-oxide-induced hepatotoxicity in humans and rodents suggested that the contents of both PAs and PA N-oxides present in herbs and foods should be regulated and controlled in use.

  16. Sinusoidal Obstruction Syndrome during Treatment for Wilms' Tumor: A Life-threatening Complication.

    Science.gov (United States)

    Totadri, Sidharth; Trehan, Amita; Bansal, Deepak; Jain, Richa

    2017-01-01

    Survival rates exceed 90% in Wilms' tumor (WT). Actinomycin-D (ACT-D) which is indispensable in the management of WT is associated with the development of sinusoidal obstruction syndrome (SOS), a potentially fatal complication. The aim is to study the presentation, management, and outcome of SOS complicating ACT-D administration in WT. Retrospective file review conducted in a Pediatric Hematology-Oncology unit. Patients diagnosed and treated for WT from January 2012 to December 2015 were analyzed. SOS was diagnosed clinically, based on McDonalds criteria, requiring two of the following: jaundice, hepatomegaly and/or right upper quadrant pain, weight gain with or without ascites. Of 104 patients treated, SOS occurred in 5 (4.8%). Age: 6 months to 5 years, 3 were girls. Tumor involved left kidney in 3, right in 1 and a horseshoe kidney in 1. Histopathology was consistent with WT in 4 and clear cell sarcoma kidney in 1. One had pulmonary metastases. Three developed SOS preoperatively and two during adjuvant chemotherapy. None received radiotherapy. Clinical manifestations comprised of jaundice, hepatomegaly, ascites/weight gain, respiratory distress, hypotension, and encephalopathy. Laboratory findings included thrombocytopenia, elevated serum transaminases, and coagulopathy. Treatment included fluid restriction, broad spectrum antibiotics, and transfusional support. Two children received N-acetyl cysteine infusion. Defibrotide was administered to two patients. Four recovered and one succumbed to multi-organ failure. Two patients were safely re-challenged with 50% doses of ACT-D. SOS is a clinical diagnosis. Systematic supportive care can enable complete recovery. Under close monitoring, re-challenge of ACT-D can be performed in gradually escalating doses.

  17. Intestinal parasite prevalence in an area of ethiopia after implementing the SAFE strategy, enhanced outreach services, and health extension program.

    Directory of Open Access Journals (Sweden)

    Jonathan D King

    during enhanced outreach services are plausible explanations for the changing patterns of intestinal parasite prevalence. The extent of intestinal protozoa infections suggests poor water quality or unsanitary water collection and storage practices and warrants targeted intervention.

  18. Intestinal parasite prevalence in an area of ethiopia after implementing the SAFE strategy, enhanced outreach services, and health extension program.

    Science.gov (United States)

    King, Jonathan D; Endeshaw, Tekola; Escher, Elisabeth; Alemtaye, Genetu; Melaku, Sileabatt; Gelaye, Woyneshet; Worku, Abebe; Adugna, Mitku; Melak, Berhanu; Teferi, Tesfaye; Zerihun, Mulat; Gesese, Demelash; Tadesse, Zerihun; Mosher, Aryc W; Odermatt, Peter; Utzinger, Jürg; Marti, Hanspeter; Ngondi, Jeremiah; Hopkins, Donald R; Emerson, Paul M

    2013-01-01

    The SAFE strategy aims to reduce transmission of Chlamydia trachomatis through antibiotics, improved hygiene, and sanitation. We integrated assessment of intestinal parasites into large-scale trachoma impact surveys to determine whether documented environmental improvements promoted by a trachoma program had collateral impact on intestinal parasites. We surveyed 99 communities for both trachoma and intestinal parasites (soil-transmitted helminths, Schistosoma mansoni, and intestinal protozoa) in South Gondar, Ethiopia. One child aged 2-15 years per household was randomly selected to provide a stool sample of which about 1 g was fixed in sodium acetate-acetic acid-formalin, concentrated with ether, and examined under a microscope by experienced laboratory technicians. A total of 2,338 stool specimens were provided, processed, and linked to survey data from 2,657 randomly selected children (88% response). The zonal-level prevalence of Ascaris lumbricoides, hookworm, and Trichuris trichiura was 9.9% (95% confidence interval (CI) 7.2-12.7%), 9.7% (5.9-13.4%), and 2.6% (1.6-3.7%), respectively. The prevalence of S. mansoni was 2.9% (95% CI 0.2-5.5%) but infection was highly focal (range by community from 0-52.4%). The prevalence of any of these helminth infections was 24.2% (95% CI 17.6-30.9%) compared to 48.5% as found in a previous study in 1995 using the Kato-Katz technique. The pathogenic intestinal protozoa Giardia intestinalis and Entamoeba histolytica/E. dispar were found in 23.0% (95% CI 20.3-25.6%) and 11.1% (95% CI 8.9-13.2%) of the surveyed children, respectively. We found statistically significant increases in household latrine ownership, use of an improved water source, access to water, and face washing behavior over the past 7 years. Improvements in hygiene and sanitation promoted both by the SAFE strategy for trachoma and health extension program combined with preventive chemotherapy during enhanced outreach services are plausible explanations for the

  19. Enhancing system-wide implementation of opioid prescribing guidelines in primary care: protocol for a stepped-wedge quality improvement project.

    Science.gov (United States)

    Zgierska, Aleksandra E; Vidaver, Regina M; Smith, Paul; Ales, Mary W; Nisbet, Kate; Boss, Deanne; Tuan, Wen-Jan; Hahn, David L

    2018-06-05

    Systematic implementation of guidelines for opioid therapy management in chronic non-cancer pain can reduce opioid-related harms. However, implementation of guideline-recommended practices in routine care is subpar. The goal of this quality improvement (QI) project is to assess whether a clinic-tailored QI intervention improves the implementation of a health system-wide, guideline-driven policy on opioid prescribing in primary care. This manuscript describes the protocol for this QI project. A health system with 28 primary care clinics caring for approximately 294,000 primary care patients developed and implemented a guideline-driven policy on long-term opioid therapy in adults with opioid-treated chronic non-cancer pain (estimated N = 3980). The policy provided multiple recommendations, including the universal use of treatment agreements, urine drug testing, depression and opioid misuse risk screening, and standardized documentation of the chronic pain diagnosis and treatment plan. The project team drew upon existing guidelines, feedback from end-users, experts and health system leadership to develop a robust QI intervention, targeting clinic-level implementation of policy-directed practices. The resulting multi-pronged QI intervention included clinic-wide and individual clinician-level educational interventions. The QI intervention will augment the health system's "routine rollout" method, consisting of a single educational presentation to clinicians in group settings and a separate presentation for staff. A stepped-wedge design will enable 9 primary care clinics to receive the intervention and assessment of within-clinic and between-clinic changes in adherence to the policy items measured by clinic-level electronic health record-based measures and process measures of the experience with the intervention. Developing methods for a health system-tailored QI intervention required a multi-step process to incorporate end-user feedback and account for the needs of

  20. Effects of performance feedback and coaching on the problem-solving process: Improving the integrity of implementation and enhancing student outcomes

    Science.gov (United States)

    Lundahl, Allison A.

    Schools implementing Response to Intervention (RtI) procedures frequently engage in team problem-solving processes to address the needs of students who require intensive and individualized services. Because the effectiveness of the problem-solving process will impact the overall success of RtI systems, the present study was designed to learn more about how to strengthen the integrity of the problem-solving process. Research suggests that school districts must ensure high quality training and ongoing support to enhance the effectiveness, acceptability, and sustainability of the problem-solving process within an RtI model; however, there is a dearth of research examining the effectiveness of methods to provide this training and support. Consequently, this study investigated the effects of performance feedback and coaching strategies on the integrity with which teams of educators conducted the problem-solving process in schools. In addition, the relationships between problem-solving integrity, teacher acceptability, and student outcomes were examined. Results suggested that the performance feedback increased problem-solving procedural integrity across two of the three participating schools. Conclusions about the effectiveness of the (a) coaching intervention and (b) interventions implemented in the third school were inconclusive. Regression analyses indicated that the integrity with which the teams conducted the problem-solving process was a significant predictor of student outcomes. However, the relationship between problem-solving procedural integrity and teacher acceptability was not statistically significant.

  1. Analytical and numerical solution of three-dimensional channel flow in presence of a sinusoidal fluid injection and a chemical reaction

    Directory of Open Access Journals (Sweden)

    Sahin Ahmed

    2015-06-01

    Full Text Available Modeling of three-dimensional channel flow in a chemically-reacting fluid between two long vertical parallel flat plates in the presence of a transverse magnetic field is presented. The stationary plate is subjected to a transverse sinusoidal injection velocity distribution while the uniformly moving plate is subjected to a constant suction and slip boundary conditions. Due to this type of injection velocity, the flow becomes three dimensional. Comparisons with previously published work are performed and the results are found to be in excellent agreement. An increase in the permeability/magnetic parameter is found to escalate the velocity near the plate in motion. Growing Reynolds number or magnetic parameter enhances the x-component and reduces the z-component of the skin-friction at the wall at rest. The acquired knowledge in our study can be used by designers to control MHD flow as suitable for certain applications which include laminar magneto-aerodynamics, materials processing and MHD propulsion thermo-fluid dynamics.

  2. A Refined Self-Tuning Filter-Based Instantaneous Power Theory Algorithm for Indirect Current Controlled Three-Level Inverter-Based Shunt Active Power Filters under Non-sinusoidal Source Voltage Conditions

    Directory of Open Access Journals (Sweden)

    Yap Hoon

    2017-02-01

    Full Text Available In this paper, a refined reference current generation algorithm based on instantaneous power (pq theory is proposed, for operation of an indirect current controlled (ICC three-level neutral-point diode clamped (NPC inverter-based shunt active power filter (SAPF under non-sinusoidal source voltage conditions. SAPF is recognized as one of the most effective solutions to current harmonics due to its flexibility in dealing with various power system conditions. As for its controller, pq theory has widely been applied to generate the desired reference current due to its simple implementation features. However, the conventional dependency on self-tuning filter (STF in generating reference current has significantly limited mitigation performance of SAPF. Besides, the conventional STF-based pq theory algorithm is still considered to possess needless features which increase computational complexity. Furthermore, the conventional algorithm is mostly designed to suit operation of direct current controlled (DCC SAPF which is incapable of handling switching ripples problems, thereby leading to inefficient mitigation performance. Therefore, three main improvements are performed which include replacement of STF with mathematical-based fundamental real power identifier, removal of redundant features, and generation of sinusoidal reference current. To validate effectiveness and feasibility of the proposed algorithm, simulation work in MATLAB-Simulink and laboratory test utilizing a TMS320F28335 digital signal processor (DSP are performed. Both simulation and experimental findings demonstrate superiority of the proposed algorithm over the conventional algorithm.

  3. CMOS-based active RC sinusoidal oscillator with four-phase quadrature outputs and single-resistance-controlled (SRC) tuning laws

    OpenAIRE

    Lahiri, Abhirup; Herencsár, Norbert

    2012-01-01

    This paper proposes a very compact CMOS realization of active RC sinusoidal oscillator capable of generating four quadrature voltage outputs. The oscillator is based on the cascade of lossless and lossy integrators in loop. The governing laws for the condition of oscillation (CO) and the frequency of oscillation (FO) are single-resistance-controlled (SRC) and which allow independent FO tuning. Unlike previously reported SRC-based sinusoidal oscillators based on the active building block (ABB)...

  4. Dynamic evolution of Rayleigh-Taylor bubbles from sinusoidal, W-shaped, and random perturbations

    Science.gov (United States)

    Zhou, Zhi-Rui; Zhang, You-Sheng; Tian, Bao-Lin

    2018-03-01

    Implicit large eddy simulations of two-dimensional Rayleigh-Taylor instability at different density ratios (i.e., Atwood number A =0.05 , 0.5, and 0.9) are conducted to investigate the late-time dynamics of bubbles. To produce a flow field full of bounded, semibounded, and chaotic bubbles, three problems with distinct perturbations are simulated: (I) periodic sinusoidal perturbation, (II) isolated W-shaped perturbation, and (III) random short-wave perturbations. The evolution of height h , velocity v , and diameter D of the (dominant) bubble with time t are formulated and analyzed. In problem I, during the quasisteady stage, the simulations confirm Goncharov's prediction of the terminal speed v∞=Fr√{A g λ /(1 +A ) } , where Fr=1 /√{3 π } . Moreover, the diameter D at this stage is found to be proportional to the initial perturbation wavelength λ as D ≈λ . This differed from Daly's simulation result of D =λ (1 +A )/2 . In problem II, a W-shaped perturbation is designed to produce a bubble environment similar to that of chaotic bubbles in problem III. We obtain a similar terminal speed relationship as above, but Fr is replaced by Frw≈0.63 . In problem III, the simulations show that h grows quadratically with the bubble acceleration constant α ≡h /(A g t2)≈0.05 , and D expands self-similarly with a steady aspect ratio β ≡D /h ≈(1 +A )/2 , which differs from existing theories. Therefore, following the mechanism of self-similar growth, we derive a relationship of β =4 α (1 +A ) /Frw2 to relate the evolution of chaotic bubbles in problem III to that of semibounded bubbles in problem II. The validity of this relationship highlights the fact that the dynamics of chaotic bubbles in problem III are similar to the semibounded isolated bubbles in problem II, but not to that of bounded periodic bubbles in problem I.

  5. Assessing student understanding of sound waves and trigonometric reasoning in a technology-rich, project-enhanced environment

    Science.gov (United States)

    Wilhelm, Jennifer Anne

    This case study examined what student content understanding could occur in an inner city Industrial Electronics classroom located at Tree High School where project-based instruction, enhanced with technology, was implemented for the first time. Students participated in a project implementation unit involving sound waves and trigonometric reasoning. The unit was designed to foster common content learning (via benchmark lessons) by all students in the class, and to help students gain a deeper conceptual understanding of a sub-set of the larger content unit (via group project research). The objective goal of the implementation design unit was to have students gain conceptual understanding of sound waves, such as what actually waves in a wave, how waves interfere with one another, and what affects the speed of a wave. This design unit also intended for students to develop trigonometric reasoning associated with sinusoidal curves and superposition of sinusoidal waves. Project criteria within this design included implementation features, such as the need for the student to have a driving research question and focus, the need for benchmark lessons to help foster and scaffold content knowledge and understanding, and the need for project milestones to complete throughout the implementation unit to allow students the time for feedback and revision. The Industrial Electronics class at Tree High School consisted of nine students who met daily during double class periods giving 100 minutes of class time per day. The class teacher had been teaching for 18 years (mathematics, physics, and computer science). He had a background in engineering and experience teaching at the college level. Benchmark activities during implementation were used to scaffold fundamental ideas and terminology needed to investigate characteristics of sound and waves. Students participating in benchmark activities analyzed motion and musical waveforms using probeware, and explored wave phenomena using waves

  6. Dai-kenchu-to attenuates rat sinusoidal obstruction syndrome by inhibiting the accumulation of neutrophils in the liver.

    Science.gov (United States)

    Narita, Masato; Hatano, Etsuro; Tamaki, Nobuyuki; Yamanaka, Kenya; Yanagida, Atsuko; Nagata, Hiromitsu; Asechi, Hiroyuki; Takada, Yasutsugu; Ikai, Iwao; Uemoto, Shinji

    2009-06-01

    Sinusoidal obstruction syndrome (SOS) is drug-induced liver injury that occurs in patients who receive hematopoietic cell transplantation and oxaliplatin-contained chemotherapy. The aim of study was to investigate the pharmacological treatment of SOS using a traditional Japanese medicine, Dai-kenchu-to (DKT). Male Sprague-Dawley rats were treated with monocrotaline (MCT) to induce SOS. The rats were divided into three groups: control, MCT and MCT+DKT groups. In the MCT+DKT group, DKT was gavaged at 12 h after MCT treatment and given every 12 h until the end of the protocol. The rats of MCT group were treated with water instead of DKT. At 48 h after MCT treatment, blood and liver samples were collected. In the MCT+DKT group, the macroscopic and histological findings revealed liver congestion, sinusoidal alteration and the destruction of sinusoidal lining, which were comparable with those of the MCT group. However, the area of hepatic necrosis and serum AST levels significantly decreased in the MCT+DKT group compared with those of the MCT group. Treatment with DKT resulted in the reduction of neutrophil accumulation, myeloperoxidase activity and the expression of cytokine-induced neutrophil chemoattractant (CINC) and intracellular adhesion molecule-1 (ICAM-1) mRNA in the liver compared with those of the MCT group. Treatment with processed ginger, one of the ingredients in DKT, resulted in similar effects to those shown by DKT. Dai-kenchu-to attenuates MCT-induced liver injury by preventing neutrophil-induced liver injury through blockage of upregulation of CINC and ICAM-1 mRNA level.

  7. СURRENT FILTERING IN A THREE-PHASE THREE-WIRE POWER SYSTEM AT ASYMMETRIC SINUSOIDAL VOLTAGES

    Directory of Open Access Journals (Sweden)

    M. Yu. Artemenko

    2018-04-01

    Full Text Available Purpose. Investigation of the optimal current distribution between source, shunt active filter and reactive compensator of a three-phase three-wire system that provides consumption of a sinusoidal symmetric current under asymmetric source voltages with minimal power losses was provided. Methodology. The tasks were solved by conducting theoretical and experimental studies. The main provisions of the theory of electrical circuits, the apparatus of mathematical analysis, methods for solving linear differential and algebraic equations, elements of matrix and complex calculus and vector algebra are used. During the development, modern methods and software of computer simulation of electrical engineering complexes and dynamic systems were applied: Matlab-Simulink, MATHCAD. Originality. The principle of compensating current distribution between PAF and reactive compensator of a three-phase three-wire power system with asymmetric sinusoidal voltage was proposed at which the input current is equal to the positive-sequence active current and rms value of PAF current is minimal. The feasibility to compensate the inactive sinusoidal Fryze current by reactive elements under arbitrary combination of load and source parameters was proved and expression for direct calculation of the reactive compensator parameters for generation of inactive Fryze current in the source unbalanced mode was obtained. Practical value. The simulative example for transmission line load showed that combined application of PAF and reactive compensator with the specified distribution of compensating currents ensured a reduction of power losses in 3.273 times and rms value of the SAF current is 12.9 % of rms value total compensation current.

  8. [Effect of 50 Hz 1.8 mT sinusoidal electromagnetic fields on bone mineral density in growing rats].

    Science.gov (United States)

    Gao, Yu-Hai; Zhou, Yan-Feng; Li, Shao-Feng; Li, Wen-Yuan; Xi, Hui-Rong; Yang, Fang-Fang; Chen, Ke-Ming

    2017-12-25

    To study effects of 50 Hz 1.8 mT sinusoidal electromagnetic fields (SEMFs) on bone mineral density (BMD) in SD rats. Thirty SD rats weighted(110±10) and aged 1 month were randomly divided into control group and electromagnetic field group, 15 in each group. Normal control group of 50 Hz 0 mT density and sinusoidal electromagnetic field group of 50 Hz 1.8 mT were performed respectively with 1.5 h/d and weighted weight once a week, and observed food-intake. Rats were anesthesia by intraperitoneal injection and dual energy X-ray absorptiometry were used to detect bone density of whole body, and detected bone density of femur and vertebral body. Osteocalcin and tartrate-resistant acid phosphatase 5b were detected by ELSA; weighted liver, kidney and uterus to calculate purtenance index, then detected pathologic results by HE. Compared with control group, there was no significant change in weight every week, food-intake every day; no obvious change of bone density of whole body at 2 and 4 weeks, however bone density of whole body, bone density of excised femur and vertebra were increased at 6 weeks. Expression of OC was increased, and TRACP 5b expression was decreased. No change of HE has been observed in liver, kidney and uterus and organic index. 50 Hz 1.8 mT sinusoidal electromagnetic fields could improve bone formation to decrease relevant factors of bone absorbs, to improve peak bone density of young rats, in further provide a basis for clinical research electromagnetic fields preventing osteoporosis foundation.

  9. Dynamics of the Josephson multi-junction system with junctions characterized by non-sinusoidal current - phase relationship

    International Nuclear Information System (INIS)

    Abal'osheva, I.; Lewandowski, S.J.

    2004-01-01

    It is shown that the inclusion of junctions characterized by non-sinusoidal current - phase relationship in the systems composed of multiple Josephson junctions - results in the appearance of additional system phase states. Numerical simulations and stability considerations confirm that those phase states can be realized in practice. Moreover, spontaneous formation of the grain boundary junctions in high-T c superconductors with non-trivial current-phase relations due to the d-wave symmetry of the order parameter is probable. Switching between the phase states of multiple grain boundary junction systems can lead to additional 1/f noise in high-T c superconductors. (author)

  10. Sinusoidal obstruction syndrome (veno-occlusive disease in a patient receiving bevacizumab for metastatic colorectal cancer: a case report

    Directory of Open Access Journals (Sweden)

    Agarwal Vijay

    2008-07-01

    Full Text Available Abstract Introduction We present the case of a patient with colon cancer who, while receiving bevacizumab, developed sinusoidal obstruction syndrome (veno-occlusive disease (SOSVOD. Certain antitumour agents such as 6-mercaptopurine and 6-thioguanine have also been reported to initiate hepatic SOSVOD in isolated cases. There have been no reports so far correlating bevacizumab with SOSVOD. Case presentation A 77-year-old man was being treated with oxaliplatin and a modified de Gramont regimen of 5-fluorouracil for metastatic colon cancer. Bevacizumab (7.5 mg/kg was added from the seventh cycle onwards. Protracted neutropenia and thrombocytopenia led to discontinuation of oxaliplatin after the ninth cycle. A computed tomography scan showed complete response and bevacizumab was continued for another 3 months, after which time the patient developed right hypochondrial pain, transudative ascites, splenomegaly and abnormal liver function tests. Upper gastrointestinal endoscopy showed oesophageal varices. Liver biopsy showed features considered to be consistent with SOSVOD. Bevacizumab was stopped and a policy of watchful waiting was adopted. He tolerated the acute damage to his liver and subsequently the ascites resolved and liver function tests normalised. Conclusion We need to be aware that bevacizumab can cause sinusoidal obstruction syndrome (veno-occlusive disease and that the occurrence of ascites should not be attributed to progressive disease without appropriate evaluation.

  11. Time-frequency analyses of fluid-solid interaction under sinusoidal translational shear deformation of the viscoelastic rat cerebrum

    Science.gov (United States)

    Leahy, Lauren N.; Haslach, Henry W.

    2018-02-01

    During normal extracellular fluid (ECF) flow in the brain glymphatic system or during pathological flow induced by trauma resulting from impacts and blast waves, ECF-solid matter interactions result from sinusoidal shear waves in the brain and cranial arterial tissue, both heterogeneous biological tissues with high fluid content. The flow in the glymphatic system is known to be forced by pulsations of the cranial arteries at about 1 Hz. The experimental shear stress response to sinusoidal translational shear deformation at 1 Hz and 25% strain amplitude and either 0% or 33% compression is compared for rat cerebrum and bovine aortic tissue. Time-frequency analyses aim to correlate the shear stress signal frequency components over time with the behavior of brain tissue constituents to identify the physical source of the shear nonlinear viscoelastic response. Discrete fast Fourier transformation analysis and the novel application to the shear stress signal of harmonic wavelet decomposition both show significant 1 Hz and 3 Hz components. The 3 Hz component in brain tissue, whose magnitude is much larger than in aortic tissue, may result from interstitial fluid induced drag forces. The harmonic wavelet decomposition locates 3 Hz harmonics whose magnitudes decrease on subsequent cycles perhaps because of bond breaking that results in easier fluid movement. Both tissues exhibit transient shear stress softening similar to the Mullins effect in rubber. The form of a new mathematical model for the drag force produced by ECF-solid matter interactions captures the third harmonic seen experimentally.

  12. Responses of Medullary Lateral Line Units of the Goldfish, Carassius auratus, to Amplitude-Modulated Sinusoidal Wave Stimuli

    Directory of Open Access Journals (Sweden)

    Ramadan Ali

    2010-01-01

    Full Text Available This paper describes the responses of brainstem lateral line units in goldfish, Carassius auratus, to constant-amplitude and to amplitude-modulated sinusoidal water motions. If stimulated with constant-amplitude sinusoidal water motions, units responded with phasic (50% or with sustained (50% increases in dicharge rate. Based on isodisplacement curves, units preferred low (33 Hz, 12.5%, mid (50 Hz, 10% and 100 Hz, 30% or high (200 Hz, 47.5% frequencies. In most units, responses were weakly phase locked to the carrier frequency. However, at a carrier frequency of 50 Hz or 100 Hz, a substantial proportion of the units exhibited strong phase locking. If stimulated with amplitude-modulated water motions, units responded with a burst of discharge to each modulation cycle, that is, units phase locked to the amplitude modulation frequency. Response properties of brainstem units were in many respects comparable to those of midbrain units, suggesting that they emerge first in the lateral line brainstem.

  13. Cost savings and enhanced hospice enrollment with a home-based palliative care program implemented as a hospice-private payer partnership.

    Science.gov (United States)

    Kerr, Christopher W; Donohue, Kathleen A; Tangeman, John C; Serehali, Amin M; Knodel, Sarah M; Grant, Pei C; Luczkiewicz, Debra L; Mylotte, Kathleen; Marien, Melanie J

    2014-12-01

    In the United States, 5% of the population is responsible for nearly half of all health care expenditures, with a large concentration of spending driven by individuals with expensive chronic conditions in their last year of life. Outpatient palliative care under the Medicare Hospice Benefit excludes a large proportion of the chronically ill and there is widespread recognition that innovative strategies must be developed to meet the needs of the seriously ill while reducing costs. This study aimed to evaluate the impact of a home-based palliative care program, implemented through a hospice-private payer partnership, on health care costs and utilization. This was a prospective, observational database study where insurance enrollment and claims data were analyzed. The study population consisted of Home Connections (HC) program patients enrolled between January 1, 2010 and December 31, 2012 who subsequently expired (n=149) and who were also Independent Health members. A control group (n=537) was derived using propensity-score matching. The primary outcome variable was overall costs within the last year of life. Costs were also examined at six months, three months, one month, and two weeks. Inpatient, outpatient, ancillary, professional, and pharmacy costs were compared between the two groups. Medical service utilization and hospice enrollment and length of stay were also evaluated. Cost savings were apparent in the last three months of life—$6,804 per member per month (PMPM) cost for palliative care participants versus $10,712 for usual care. During the last two weeks of life, total allowed PMPM was $6,674 versus $13,846 for usual care. Enhanced hospice entry (70% versus 25%) and longer length of stay in hospice (median 34 versus 9 days) were observed. Palliative care programs partnered with community hospice providers may achieve cost savings while helping provide care across the continuum.

  14. Driving and control strategies in alternative current machines of permanent magnet with non-sinusoidal flux; Estrategias de acionamento e controle em maquinas CA de ima permanente com fluxo nao senoidal

    Energy Technology Data Exchange (ETDEWEB)

    Monteiro, Jose Roberto Boffino de Almeida

    1997-07-01

    The aim of this work is to study and analyze the torque performance of brush less machines with non-sinusoidal distributed magnetic fluxes. The machine type considered is a surface mount permanent magnet brush less machine. Three mathematical models for the machine are considered: the per stator phase, the vectorial and the linear second order speed-voltage models. Machines with different stator windings are compared including the permanent magnet synchronous machines with sinusoidal distributed stator windings. The torque outputs of these machines are obtained considering two kinds of open loop driving systems: one with a six-pulse waveform and other with a sinusoidal waveform. Finally, a vectorial control is proposed for the non-sinusoidal machines. The torque ripple as well the overall performance of non-sinusoidal machines with vectorial control is compared to that of sinusoidal machines. (author)

  15. Coeur d'Alene Tribe Fisheries Program : Implementation of Fisheries Enhancement Opportunities on the Coeur d’Alene Reservation : 2007 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Firehammer, Jon A.; Vitale, Angelo J.; Hallock, Stephanie A. [Coeur d' Alene Tribe Department of Natural Resources Fisheries Program

    2009-09-08

    diversity, and increase the probability of persistence in the face of anthropogenic influences and prospective climate change. This included recovering the lacustrine-adfluvial life history form that was historically prevalent and had served to provide both resilience and resistance to the structure of cutthroat trout populations in the Coeur d'Alene basin. To this end, the Coeur d'Alene Tribe closed Lake Creek and Benewah Creek to fishing in 1993 to initiate recovery of westslope cutthroat trout to historical levels. However, achieving sustainable cutthroat trout populations also required addressing biotic factors and habitat features in the basin that were limiting recovery. Early in the 1990s, BPA-funded surveys and inventories identified limiting factors in Tribal watersheds that would need to be remedied to restore westslope cutthroat trout populations. The limiting factors included: low-quality, low-complexity mainstem stream habitat and riparian zones; high stream temperatures in mainstem habitats; negative interactions with nonnative brook trout in tributaries; and potential survival bottlenecks in Coeur d'Alene Lake. In 1994, the Northwest Power Planning Council adopted the recommendations set forth by the Coeur d'Alene Tribe to improve the Reservation fishery (NWPPC Program Measures 10.8B.20). These recommended actions included: (1) Implement habitat restoration and enhancement measures in Alder, Benewah, Evans, and Lake Creeks; (2) Purchase critical watershed areas for protection of fisheries habitat; (3) Conduct an educational/outreach program for the general public within the Coeur d'Alene Reservation to facilitate a 'holistic' watershed protection process; (4) Develop an interim fishery for tribal and non-tribal members of the reservation through construction, operation and maintenance of five trout ponds; (5) Design, construct, operate and maintain a trout production facility; and (6) Implement a monitoring program to

  16. Implementation of Fisheries Enhancement Opportunities on the Coeur d'Alene Reservation; Coeur d'Alene Tribe Fish, Water, and Wildlife Program, REVISED 2002 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Vitale, Angelo; Lamb, Dave; Scott, Jason

    2004-04-01

    actions included: (1) Implement habitat restoration and enhancement measures in Alder, Benewah, Evans, and Lake Creeks; (2) Purchase critical watershed areas for protection of fisheries habitat; (3) Conduct an educational/outreach program for the general public within the Coeur d'Alene Reservation to facilitate a 'holistic' watershed protection process; (4) Develop an interim fishery for tribal and non-tribal members of the reservation through construction, operation and maintenance of five trout ponds; (5) Design, construct, operate and maintain a trout production facility; and (6) Implement a five-year monitoring program to evaluate the effectiveness of the hatchery and habitat improvement projects. Since that time, much of the mitigation activities occurring within the Coeur d'Alene sub-basin have had a connection to the project entitled 'Implement of Fisheries Enhancement Opportunities on the Coeur d'Alene Reservation', which is sponsored and implemented by the Coeur d'Alene Tribe Fisheries Program and is the subject of this report.

  17. CD147 promotes liver fibrosis progression via VEGF-A/VEGFR2 signalling-mediated cross-talk between hepatocytes and sinusoidal endothelial cells.

    Science.gov (United States)

    Yan, Zhaoyong; Qu, Kai; Zhang, Jing; Huang, Qichao; Qu, Ping; Xu, Xinsen; Yuan, Peng; Huang, Xiaojun; Shao, Yongping; Liu, Chang; Zhang, Hongxin; Xing, Jinliang

    2015-10-01

    Although previous evidence indicates close involvement of CD147 in the pathogenesis of liver fibrosis, the underlying molecular mechanisms and its therapeutic value remain largely unknown. In the present study, we investigated the biological roles of CD147 in liver fibrosis and assessed its therapeutic value as a target molecule in the CCl4-induced liver fibrosis mouse model. We found that CD147 was highly expressed in both hepatocytes and SECs (sinusoidal endothelial cells) in fibrotic liver tissues. Additionally, it was significantly associated with the fibrosis stage. TGF-β1 (transforming growth factor β1) was found to be mainly responsible for the up-regulation of CD147. Bioinformatic and experimental data suggest a functional link between CD147 expression and VEGF-A (vascular endothelial growth factor A)/VEGR-2 (VEGF receptor 2) signalling-mediated angiogenesis in fibrotic liver tissues. Furthermore, we observed that the CD147-induced activation of the PI3K (phosphoinositide 3-kinase)/Akt signalling pathway promotes the production of VEGF-A in hepatocytes and expression of VEGFR-2 in SECs, which was found to enhance the angiogenic capability of SECs. Finally, our data indicate that blocking of CD147 using an mAb (monoclonal antibody) attenuated liver fibrosis progression via inhibition of VEGF-A/VEGFR-2 signalling and subsequent amelioration of microvascular abnormality in the CCl4-induced mouse model. Our findings suggest a novel functional mechanism that CD147 may promote liver fibrosis progression via inducing the VEGF-A/VEGFR-2 signalling pathway-mediated cross-talk between hepatocytes and SECs. New strategies based on the intervention of CD147 can be expected for prevention of liver fibrosis. © 2015 Authors; published by Portland Press Limited.

  18. Losses analysis of soft magnetic ring core under sinusoidal pulse width modulation (SPWM) and space vector pulse width modulation (SVPWM) excitations

    Science.gov (United States)

    Gao, Hezhe; Li, Yongjian; Wang, Shanming; Zhu, Jianguo; Yang, Qingxin; Zhang, Changgeng; Li, Jingsong

    2018-05-01

    Practical core losses in electrical machines differ significantly from those experimental results using the standardized measurement method, i.e. Epstein Frame method. In order to obtain a better approximation of the losses in an electrical machine, a simulation method considering sinusoidal pulse width modulation (SPWM) and space vector pulse width modulation (SVPWM) waveforms is proposed. The influence of the pulse width modulation (PWM) parameters on the harmonic components in SPWM and SVPWM is discussed by fast Fourier transform (FFT). Three-level SPWM and SVPWM are analyzed and compared both by simulation and experiment. The core losses of several ring samples magnetized by SPWM, SVPWM and sinusoidal alternating current (AC) are obtained. In addition, the temperature rise of the samples under SPWM, sinusoidal excitation are analyzed and compared.

  19. Successful treatment of severe sinusoidal obstruction syndrome despite multiple organ failure with defibrotide after allogeneic stem cell transplantation: a case report

    Directory of Open Access Journals (Sweden)

    Behre Gerhard

    2009-03-01

    Full Text Available Abstract Introduction We report a case of sinusoidal obstruction syndrome, a typical and life-threatening complication after allogeneic stem-cell transplantation, successfully treated with defibrotide despite massive multiple organ failure. Case presentation A 64-year-old Caucasian woman underwent allogeneic peripheral blood stem-cell transplantation from her human leukocyte antigen-identical sister against aggressive lymphoplasmocytoid immunocytoma. Seven days later, the patient developed severe sinusoidal obstruction syndrome according to the modified Seattle criteria. We initiated treatment with defibrotide. Despite early treatment, multiple organ failure with kidney failure requiring dialysis and ventilator-dependent lung failure aggravated the clinical course. Furthermore, central nervous dysfunction occurred as well as transfusion refractory thrombocytopenia. Conclusion As highlighted in our report, defibrotide is the most promising drug in the treatment of the formerly, almost lethal, severe sinusoidal obstruction syndrome to date. This is demonstrated very clearly in our patient. She improved completely, even after renal, cerebral and respiratory failure.

  20. Successful treatment of severe sinusoidal obstruction syndrome despite multiple organ failure with defibrotide after allogeneic stem cell transplantation: a case report.

    Science.gov (United States)

    Behre, Gerhard; Theurich, Sebastian; Christopeit, Maximilian; Weber, Thomas

    2009-03-10

    We report a case of sinusoidal obstruction syndrome, a typical and life-threatening complication after allogeneic stem-cell transplantation, successfully treated with defibrotide despite massive multiple organ failure. A 64-year-old Caucasian woman underwent allogeneic peripheral blood stem-cell transplantation from her human leukocyte antigen-identical sister against aggressive lymphoplasmocytoid immunocytoma. Seven days later, the patient developed severe sinusoidal obstruction syndrome according to the modified Seattle criteria. We initiated treatment with defibrotide. Despite early treatment, multiple organ failure with kidney failure requiring dialysis and ventilator-dependent lung failure aggravated the clinical course. Furthermore, central nervous dysfunction occurred as well as transfusion refractory thrombocytopenia. As highlighted in our report, defibrotide is the most promising drug in the treatment of the formerly, almost lethal, severe sinusoidal obstruction syndrome to date. This is demonstrated very clearly in our patient. She improved completely, even after renal, cerebral and respiratory failure.

  1. A two-level voltage source inverter with differentially sinusoidal pulse width modulation used in the interconnection system of a wind turbine generator

    Directory of Open Access Journals (Sweden)

    Alexandros C. Charalampidis

    2014-10-01

    Full Text Available This study analyses an interconnection system based on differentially sinusoidal pulse width modulation, used for the interconnection to the grid of a variable speed wind turbine. The modulation technique used provides specific advantages in comparison with the commonly used sinusoidal pulse width modulation (SPWM technique, such as lower DC bus voltage requirements, smaller switching losses for the same switching frequency as well as less higher harmonic content in the voltage waveforms produced. The respective control system is also described in detail. Thus this study provides a guide enabling the design of any interconnection system based on this modulation technique.

  2. Phase-locking and chaos in a silent Hodgkin-Huxley neuron exposed to sinusoidal electric field

    International Nuclear Information System (INIS)

    Che Yanqiu; Wang Jiang; Si Wenjie; Fei Xiangyang

    2009-01-01

    Neuronal firing patterns are related to the information processing in neural system. This paper investigates the response characteristics of a silent Hodgkin-Huxley neuron to the stimulation of externally-applied sinusoidal electric field. The neuron exhibits both p:q phase-locked (i.e. a periodic oscillation defined as p action potentials generated by q cycle stimulations) and chaotic behaviors, depending on the values of stimulus frequencies and amplitudes. In one-parameter space, a rich bifurcation structure including period-adding without chaos and phase-locking alternated with chaos suggests frequency discrimination of the neuronal firing patterns. Furthermore, by mapping out Arnold tongues, we partition the amplitude-frequency parameter space in terms of the qualitative behaviors of the neuron. Thus the neuron's information (firing patterns) encodes the stimulus information (amplitude and frequency), and vice versa

  3. Manifestations and management of veno-occlusive disease/sinusoidal obstruction syndrome in the era of contemporary therapies.

    Science.gov (United States)

    Tewari, Priti; Wallis, Whitney; Kebriaei, Partow

    2017-02-01

    The concept of veno-occlusive disease (VOD), along with our understanding of it, has historically been and remains an evolving phenomenon. This review presents a broad view of VOD, also known as sinusoidal obstruction syndrome (SOS), including (1) traditional hematopoietic stem cell transplant-associated VOD/SOS, (2) late-onset VOD/SOS, (3) pulmonary VOD, and (4) VOD/SOS associated with chemotherapy only. Several VOD/SOS management modalities exist that include modes for both prophylaxis and treatment. An extensive review of the literature on monoclonal antibodies, both approved and pending approval by the US Food and Drug Administration, reveals that only a few have been associated with an increased risk for VOD/SOS. In fact, bevacizumab appears to have a protective effect against the development of VOD/SOS. As the landscape of cancer treatment changes, careful attention needs to be focused on how new therapies affect the incidence of VOD/SOS.

  4. "Pre-emptive strike"-the case for early treatment of hepatic sinusoidal obstruction syndrome with defibrotide.

    Science.gov (United States)

    Rajagopal, Revathi; Phillips, Marianne B; Gottardo, Nicholas G

    2018-07-01

    The initial signs of hepatic sinusoidal obstruction syndrome (HSOS) can be challenging to recognize in children, especially outside the hematopoietic stem cell transplantation setting. To assist clinicians to promptly identify HSOS, the European Society for Blood and Marrow Transplantation has proposed pediatric HSOS diagnostic criteria which emphasize unexplained consumptive and transfusion-refractory thrombocytopenia. To highlight the importance of these "bellwether" early signs of HSOS and the efficacy of pre-emptive treatment with defibrotide, we describe the case of a child with a right 11th rib primitive neuroectodermal tumor who developed HSOS following focal radiotherapy and actinomycin-D treatment. © 2018 The Authors. Pediatric Blood & Cancer Published by Wiley Periodicals, Inc.

  5. Hepatic Sinusoidal Obstruction Syndrome During Chemotherapy for Childhood Medulloblastoma: Report of a Case and Review of the Literature

    Science.gov (United States)

    Buckland, Amy; Phillips, Marianne B.; Cole, Catherine H.; Gottardo, Nicholas G.

    2014-01-01

    Hepatic sinusoidal obstruction syndrome (HSOS), also known as veno-occlusive disease, is a well-recognized toxic complication after autologous and allogeneic hematopoietic stem cell transplant, during treatment of Wilms tumor and rhabdomyosarcoma associated with actinomycin-D, and during acute lymphoblastic leukemia therapy due to oral 6-thioguanine. However, its occurrence in the context of chemotherapy regimens for other childhood malignancies is rare. We report a 5-year-old girl with high-risk anaplastic medulloblastoma, who developed severe HSOS during her second cycle of maintenance chemotherapy, consisting of vincristine, cisplatin, and cyclophosphamide. She was treated with defibrotide with complete resolution of the HSOS. These findings and a review of the literature, highlight the occurrence of HSOS in children outside the established settings of hematopoietic stem cell transplantation, Wilms tumor, rhabdomyosarcoma, and acute lymphoblastic leukemia. PMID:24276042

  6. Evaluation and statistical judgement of neural responses to sinusoidal stimulation in cases with superimposed drift and noise.

    Science.gov (United States)

    Jastreboff, P W

    1979-06-01

    Time histograms of neural responses evoked by sinuosidal stimulation often contain a slow drifting and an irregular noise which disturb Fourier analysis of these responses. Section 2 of this paper evaluates the extent to which a linear drift influences the Fourier analysis, and develops a combined Fourier and linear regression analysis for detecting and correcting for such a linear drift. Usefulness of this correcting method is demonstrated for the time histograms of actual eye movements and Purkinje cell discharges evoked by sinusoidal rotation of rabbits in the horizontal plane. In Sect. 3, the analysis of variance is adopted for estimating the probability of the random occurrence of the response curve extracted by Fourier analysis from noise. This method proved to be useful for avoiding false judgements as to whether the response curve was meaningful, particularly when the response was small relative to the contaminating noise.

  7. 3D palmprint and hand imaging system based on full-field composite color sinusoidal fringe projection technique.

    Science.gov (United States)

    Zhang, Zonghua; Huang, Shujun; Xu, Yongjia; Chen, Chao; Zhao, Yan; Gao, Nan; Xiao, Yanjun

    2013-09-01

    Palmprint and hand shape, as two kinds of important biometric characteristics, have been widely studied and applied to human identity recognition. The existing research is based mainly on 2D images, which lose the third-dimensional information. The biological features extracted from 2D images are distorted by pressure and rolling, so the subsequent feature matching and recognition are inaccurate. This paper presents a method to acquire accurate 3D shapes of palmprint and hand by projecting full-field composite color sinusoidal fringe patterns and the corresponding color texture information. A 3D imaging system is designed to capture and process the full-field composite color fringe patterns on hand surface. Composite color fringe patterns having the optimum three fringe numbers are generated by software and projected onto the surface of human hand by a digital light processing projector. From another viewpoint, a color CCD camera captures the deformed fringe patterns and saves them for postprocessing. After compensating for the cross talk and chromatic aberration between color channels, three fringe patterns are extracted from three color channels of a captured composite color image. Wrapped phase information can be calculated from the sinusoidal fringe patterns with high precision. At the same time, the absolute phase of each pixel is determined by the optimum three-fringe selection method. After building up the relationship between absolute phase map and 3D shape data, the 3D palmprint and hand are obtained. Color texture information can be directly captured or demodulated from the captured composite fringe pattern images. Experimental results show that the proposed method and system can yield accurate 3D shape and color texture information of the palmprint and hand shape.

  8. Detailed comparative study regarding different formulae of predicting the iron losses in a machine excited by non-sinusoidal supply

    International Nuclear Information System (INIS)

    El-Kharashi, Eyhab

    2014-01-01

    Variable-speed drives in any machine provide an accurate control and high-energy efficiency. More and more often machines are excited by non-sinusoidal voltages. Predicting the amount of iron losses in non-sinusoidal excitation is important. The paper aims to achieve accurate efficiency estimation by presenting a new modified calculation method to predict the iron losses. In a switched reluctance motor, the iron losses can't be ignored, it has considered value. This paper presents conventional and modified Steinmetz formulae for the estimation of the iron losses. The conventional Steinmetz formula consists of three terms: hysteresis, eddy current and anomalous losses. The equations of hysteresis and eddy current losses depend mainly on the value of the peak flux density. The reason to modify the Steinmetz formula is to avoid the need of knowing the peak flux density and the anomalous losses in accurate figures. The paper also explains and clarifies the methods of using both the conventional as well as the modified Steinmetz formulae in accurate calculation of the iron losses in different sections of the magnetic circuit. For both formulae, a comparison is made between the distributions of the iron losses in different parts of the magnetic circuit and the efficiencies. - Highlights: • The paper aims to achieve accurate efficiency estimation. • The predicted iron loss by the conventional Steinmetz formula is inaccurate. • The modified Steinmetz formula is more accurate because it includes the minor loops losses caused by each flux density. • The paper compared the predicted losses obtained by the two different formals to stand on the degree of accuracy

  9. Download Your Doctor: Implementation of a Digitally Mediated Personal Physician Presence to Enhance Patient Engagement With a Health-Promoting Internet Application.

    Science.gov (United States)

    Lygidakis, Charilaos; Wallace, Paul; Tersar, Costanza; Marcatto, Francesco; Ferrante, Donatella; Della Vedova, Roberto; Scafuri, Francesca; Scafato, Emanuele; Struzzo, Pierluigi

    2016-03-04

    Brief interventions delivered in primary health care are effective in reducing excessive drinking; online behavior-changing technique interventions may be helpful. Physicians may actively encourage the use of such interventions by helping patients access selected websites (a process known as "facilitated access"). Although the therapeutic working alliance plays a significant role in the achievement of positive outcomes in face-to-face psychotherapy and its development has been shown to be feasible online, little research has been done on its impact on brief interventions. Strengthening patients' perception of their physician's endorsement of a website could facilitate the development of an effective alliance between the patient and the app. We describe the implementation of a digitally mediated personal physician presence to enhance patient engagement with an alcohol-reduction website as part of the experimental online intervention in a noninferiority randomized controlled trial. We also report the feedback of the users on the module. The Download Your Doctor module was created to simulate the personal physician presence for an alcohol-reduction website that was developed for the EFAR-FVG trial conducted in the Italian region of Friuli-Venezia-Giulia. The module was designed to enhance therapeutic alliance and thus improve outcomes in the intervention group (facilitated access to the website). Participating general and family practitioners could customize messages and visual elements and upload a personal photo, signature, and video recordings. To assess the perceptions and attitudes of the physicians, a semistructured interview was carried out 3 months after the start of the trial. Participating patients were invited to respond to a short online questionnaire 12 months following recruitment to investigate their evaluation of their online experiences. Nearly three-quarters (23/32, 72%) of the physicians interviewed chose to customize the contents of the interaction

  10. Decrease of PECAM-1-gene-expression induced by proinflammatory cytokines IFN-γ and IFN-α is reversed by TGF-β in sinusoidal endothelial cells and hepatic mononuclear phagocytes

    Directory of Open Access Journals (Sweden)

    Ramadori Giuliano

    2008-05-01

    Full Text Available Abstract Background and aim The mechanisms of transmigration of inflammatory cells through the sinusoids are still poorly understood. This study aims to identify in vitro conditions (cytokine treatment which may allow a better understanding of the changes in PECAM (platelet endothelial cell adhesion molecule-1-gene-expression observed in vivo. Methods and results In this study we show by immunohistochemistry, that there is an accumulation of ICAM-1 (intercellular cell adhesion molecule-1 and ED1 positive cells in necrotic areas of livers of CCl4-treated rats, whereas there are few PECAM-1 positive cells observable. After the administration of CCl4, we could detect an early rise of levels of IFN-γ followed by an enhanced TGF-β protein level. As shown by Northern blot analysis and surface protein expression analysed by flow cytometry, IFN-γ-treatment decreased PECAM-1-gene-expression in isolated SECs (sinusoidal endothelial cells and mononuclear phagocytes (MNPs in parallel with an increase in ICAM-1-gene-expression in a dose and time dependent manner. In contrast, TGF-β-treatment increased PECAM-1-expression. Additional administration of IFN-γ to CCl4-treated rats and observations in IFN-γ-/- mice confirmed the effect of IFN-γ on PECAM-1 and ICAM-1-expression observed in vitro and increased the number of ED1-expressing cells 12 h after administration of the toxin. Conclusion The early decrease of PECAM-1-expression and the parallel increase of ICAM-1-expression following CCl4-treatment is induced by elevated levels of IFN-γ in livers and may facilitate adhesion and transmigration of inflammatory cells. The up-regulation of PECAM-1-expression in SECs and MNPs after TGF-β-treatment suggests the involvement of PECAM-1 during the recovery after liver damage.

  11. The reliability of nonlinear least-squares algorithm for data analysis of neural response activity during sinusoidal rotational stimulation in semicircular canal neurons.

    Science.gov (United States)

    Ren, Pengyu; Li, Bowen; Dong, Shiyao; Chen, Lin; Zhang, Yuelin

    2018-01-01

    Although many mathematical methods were used to analyze the neural activity under sinusoidal stimulation within linear response range in vestibular system, the reliabilities of these methods are still not reported, especially in nonlinear response range. Here we chose nonlinear least-squares algorithm (NLSA) with sinusoidal model to analyze the neural response of semicircular canal neurons (SCNs) during sinusoidal rotational stimulation (SRS) over a nonlinear response range. Our aim was to acquire a reliable mathematical method for data analysis under SRS in vestibular system. Our data indicated that the reliability of this method in an entire SCNs population was quite satisfactory. However, the reliability was strongly negatively depended on the neural discharge regularity. In addition, stimulation parameters were the vital impact factors influencing the reliability. The frequency had a significant negative effect but the amplitude had a conspicuous positive effect on the reliability. Thus, NLSA with sinusoidal model resulted a reliable mathematical tool for data analysis of neural response activity under SRS in vestibular system and more suitable for those under the stimulation with low frequency but high amplitude, suggesting that this method can be used in nonlinear response range. This method broke out of the restriction of neural activity analysis under nonlinear response range and provided a solid foundation for future study in nonlinear response range in vestibular system.

  12. A transgenic model for conditional induction and rescue of portal hypertension reveals a role of VEGF-mediated regulation of sinusoidal fenestrations.

    Directory of Open Access Journals (Sweden)

    Dalit May

    Full Text Available Portal hypertension (PH is a common complication and a leading cause of death in patients with chronic liver diseases. PH is underlined by structural and functional derangement of liver sinusoid vessels and its fenestrated endothelium. Because in most clinical settings PH is accompanied by parenchymal injury, it has been difficult to determine the precise role of microvascular perturbations in causing PH. Reasoning that Vascular Endothelial Growth Factor (VEGF is required to maintain functional integrity of the hepatic microcirculation, we developed a transgenic mouse system for a liver-specific-, reversible VEGF inhibition. The system is based on conditional induction and de-induction of a VEGF decoy receptor that sequesters VEGF and preclude signaling. VEGF blockade results in sinusoidal endothelial cells (SECs fenestrations closure and in accumulation and transformation of the normally quiescent hepatic stellate cells, i.e. provoking the two processes underlying sinusoidal capillarization. Importantly, sinusoidal capillarization was sufficient to cause PH and its typical sequela, ascites, splenomegaly and venous collateralization without inflicting parenchymal damage or fibrosis. Remarkably, these dramatic phenotypes were fully reversed within few days from lifting-off VEGF blockade and resultant re-opening of SECs' fenestrations. This study not only uncovered an indispensible role for VEGF in maintaining structure and function of mature SECs, but also highlights the vasculo-centric nature of PH pathogenesis. Unprecedented ability to rescue PH and its secondary manifestations via manipulating a single vascular factor may also be harnessed for examining the potential utility of de-capillarization treatment modalities.

  13. Effects of frequency and duration on psychometric functions for detection of increments and decrements in sinusoids in noise.

    Science.gov (United States)

    Moore, B C; Peters, R W; Glasberg, B R

    1999-12-01

    Psychometric functions for detecting increments or decrements in level of sinusoidal pedestals were measured for increment and decrement durations of 5, 10, 20, 50, 100, and 200 ms and for frequencies of 250, 1000, and 4000 Hz. The sinusoids were presented in background noise intended to mask spectral splatter. A three-interval, three-alternative procedure was used. The results indicated that, for increments, the detectability index d' was approximately proportional to delta I/I. For decrements, d' was approximately proportional to delta L. The slopes of the psychometric functions increased (indicating better performance) with increasing frequency for both increments and decrements. For increments, the slopes increased with increasing increment duration up to 200 ms at 250 and 1000 Hz, but at 4000 Hz they increased only up to 50 ms. For decrements, the slopes increased for durations up to 50 ms, and then remained roughly constant, for all frequencies. For a center frequency of 250 Hz, the slopes of the psychometric functions for increment detection increased with duration more rapidly than predicted by a "multiple-looks" hypothesis, i.e., more rapidly than the square root of duration, for durations up to 50 ms. For center frequencies of 1000 and 4000 Hz, the slopes increased less rapidly than predicted by a multiple-looks hypothesis, for durations greater than about 20 ms. The slopes of the psychometric functions for decrement detection increased with decrement duration at a rate slightly greater than the square root of duration, for durations up to 50 ms, at all three frequencies. For greater durations, the increase in slope was less than proportional to the square root of duration. The results were analyzed using a model incorporating a simulated auditory filter, a compressive nonlinearity, a sliding temporal integrator, and a decision device based on a template mechanism. The model took into account the effects of both the external noise and an assumed internal

  14. A national evaluation of a dissemination and implementation initiative to enhance primary care practice capacity and improve cardiovascular disease care: the ESCALATES study protocol.

    Science.gov (United States)

    Cohen, Deborah J; Balasubramanian, Bijal A; Gordon, Leah; Marino, Miguel; Ono, Sarah; Solberg, Leif I; Crabtree, Benjamin F; Stange, Kurt C; Davis, Melinda; Miller, William L; Damschroder, Laura J; McConnell, K John; Creswell, John

    2016-06-29

    The Agency for Healthcare Research and Quality (AHRQ) launched the EvidenceNOW Initiative to rapidly disseminate and implement evidence-based cardiovascular disease (CVD) preventive care in smaller primary care practices. AHRQ funded eight grantees (seven regional Cooperatives and one independent national evaluation) to participate in EvidenceNOW. The national evaluation examines quality improvement efforts and outcomes for more than 1500 small primary care practices (restricted to those with fewer than ten physicians per clinic). Examples of external support include practice facilitation, expert consultation, performance feedback, and educational materials and activities. This paper describes the study protocol for the EvidenceNOW national evaluation, which is called Evaluating System Change to Advance Learning and Take Evidence to Scale (ESCALATES). This prospective observational study will examine the portfolio of EvidenceNOW Cooperatives using both qualitative and quantitative data. Qualitative data include: online implementation diaries, observation and interviews at Cooperatives and practices, and systematic assessment of context from the perspective of Cooperative team members. Quantitative data include: practice-level performance on clinical quality measures (aspirin prescribing, blood pressure and cholesterol control, and smoking cessation; ABCS) collected by Cooperatives from electronic health records (EHRs); practice and practice member surveys to assess practice capacity and other organizational and structural characteristics; and systematic tracking of intervention delivery. Quantitative, qualitative, and mixed methods analyses will be conducted to examine how Cooperatives organize to provide external support to practices, to compare effectiveness of the dissemination and implementation approaches they implement, and to examine how regional variations and other organization and contextual factors influence implementation and effectiveness. ESCALATES is

  15. Study protocol of an economic evaluation of an enhanced implementation strategy for the treatment of low back pain in general practice

    DEFF Research Database (Denmark)

    Jensen, Cathrine; Riis, Allan; Pedersen, Kjeld Møller

    2014-01-01

    on the design of the health economic evaluation. Methods/design: The economic evaluation is carried out alongside a cluster randomised controlled trial consisting of 60 general practices in the North Denmark Region. An expected 1,200 patients between the age of 18 and 65 years with a low back pain diagnosis...... include all relevant additional costs of the extended implementation strategy compared to usual implementation. The economic evaluation will be performed from both a societal perspective and a health sector perspective with a 12-month time horizon. Discussion: It is expected that the extended...

  16. Generation of equivalent forms of operational trans-conductance amplifier-RC sinusoidal oscillators: the nullor approach

    Directory of Open Access Journals (Sweden)

    Raj Senani

    2014-06-01

    Full Text Available It has been shown in two earlier papers published from this study that corresponding to a given single-operational trans-conductance amplifier (single-OTA-RC and dual-OTA-RC sinusoidal oscillators, there are three other structurally distinct equivalent forms having the same characteristic equation, one of which employs both grounded capacitors (GC. In this study, an earlier nullor-based theory of generating equivalent op-amp oscillator circuits, proposed by the first author, is extended to derive equivalent OTA-RC circuits which discloses the existence of an additional number of equivalent forms for the same given OTA-RC oscillators than those predicted by the quoted earlier works, and thereby considerably enlarging the set of equivalents of a given OTA-RC oscillator. Furthermore, the presented nullor-based theory of generating equivalent OTA-RC oscillators results in three additional interesting outcomes: (i the revelation that corresponding to any given OTA-RC oscillator there are two ‘both-GC’ oscillators (and not merely one, as derived in the quoted earlier works; (ii the availability of explicit current outputs in several of the derived equivalents and (iii the realisability explicit-current-output ‘quadrature oscillators’ in some of the generated equivalent oscillators. The workability of the generated equivalent OTA-RC oscillators has been verified by SPICE simulations, based on CMOS OTAs using 0.18 µm CMOS technology process parameters, and some sample results are given.

  17. Benthic Uptake Rate due to Hyporheic Exchange: The Effects of Streambed Morphology for Constant and Sinusoidally Varying Nutrient Loads

    Directory of Open Access Journals (Sweden)

    Daniele Tonina

    2015-01-01

    Full Text Available Hyporheic exchange carries reactive solutes, which may include biological oxygen demand (BOD, dissolved oxygen (DO and reactive dissolved inorganic nitrogen (Nr, into the sediment, where biochemical reactions consume DO. Here, we study the impact of streambed morphology, stream-reactive solute loads and their diel oscillations on the DO benthic uptake rate (BUR due to hyporheic processes. Our model solves the hyporheic flow field and the solute transport equations analytically, within a Lagrangian framework, considering advection, longitudinal diffusion and reactions modeled as first order kinetics. The application of the model to DO field measurements over a gravel bar-pool sequence shows a good match with measured DO concentrations with an overall agreement of 58% and a kappa index of 0.46. We apply the model to investigate the effects of daily constant and sinusoidally time varying stream BOD, DO and Nr loads and of the morphodynamic parameters on BUR. Our modeling results show that BUR varies as a function of bedform size and of nutrient loads and that the hyporheic zone may consume up to 0.06% of the stream DO at the pool-riffle bedform scale. Daily oscillations of stream BOD and DO loads have small effects on BUR, but may have an important influence on local hyporheic processes and organisms’ distribution.

  18. Characterization of Wet Air Plasma Jet Powered by Sinusoidal High Voltage and Nanosecond Pulses for Plasma Agricultural Application

    Science.gov (United States)

    Takashima, Keisuke; Shimada, Keisuke; Konishi, Hideaki; Kaneko, Toshiro

    2015-09-01

    Not only for the plasma sterilization but also for many of plasma life-science applications, atmospheric pressure plasma devices that allowed us to control its state and reactive species production are deserved to resolve the roles of the chemical species. Influence of the hydroxyl radical and ozone on germination of conidia of a strawberry pathogen is presented. Water addition to air plasma jet significantly improves germination suppression performance, while measured reactive oxygen species (ROS) are reduced. Although the results show a negative correlation between ROS and the germination suppression, this infers the importance of chemical composition generated by plasma. For further control of the plasma product, a plasma jet powered by sinusoidal high voltage and nanosecond pulses is developed and characterized with the voltage-charge Lissajous. Control of breakdown phase and discharge power by pulse-imposed phase is presented. This work is supported by JSPS KAKENHI Grant-in-Aid for Young Scientists (B) Grant Number 15K17480 and Exploratory Research Grant Number 23644199.

  19. Associations between levels of insulin-like growth factor 1 and sinusoidal obstruction syndrome after allogeneic haematopoietic stem cell transplantation

    DEFF Research Database (Denmark)

    Weischendorff, Sarah; Kielsen, Katrine; Sengeløv, H

    2017-01-01

    . We hypothesised that insulin-like growth factor-1 (IGF-1), a mediator of growth and proliferation of various tissues, may attenuate chemotherapy-induced tissue damage after HSCT. We prospectively measured plasma levels of IGF-1 and its binding protein 3 (IGFBP-3) in 41 patients undergoing...... myeloablative HSCT. IGF-1 and IGFBP-3 levels were inversely correlated with C-reactive protein and interleukin-6 levels post HSCT. In multivariate analyses, low levels of IGF-1 and IGFBP-3 before conditioning were associated with increased risk of developing sinusoidal obstruction syndrome (SOS; OR=5.00 per 1...... SDS decrease in IGF-1 (95% CI: 1.45-16.67), P=0.011 and OR=5.00 (1.37-20.00), P=0.015, respectively). Furthermore, low pre-transplant levels of IGF-1 and IGFBP-3 were associated with increased fluid retention during the first 21 days post transplant (OR=7.69 (95% CI: 1.59-33.33), P=0.012, and OR=2...

  20. Analysis and Adaptive Synchronization of Two Novel Chaotic Systems with Hyperbolic Sinusoidal and Cosinusoidal Nonlinearity and Unknown Parameters

    Directory of Open Access Journals (Sweden)

    S. Vaidyanathan

    2013-09-01

    Full Text Available This research work describes the modelling of two novel 3-D chaotic systems, the first with a hyperbolic sinusoidal nonlinearity and two quadratic nonlinearities (denoted as system (A and the second with a hyperbolic cosinusoidal nonlinearity and two quadratic nonlinearities (denoted as system (B. In this work, a detailed qualitative analysis of the novel chaotic systems (A and (B has been presented, and the Lyapunov exponents and Kaplan-Yorke dimension of these chaotic systems have been obtained. It is found that the maximal Lyapunov exponent (MLE for the novel chaotic systems (A and (B has a large value, viz. for the system (A and for the system (B. Thus, both the novel chaotic systems (A and (B display strong chaotic behaviour. This research work also discusses the problem of finding adaptive controllers for the global chaos synchronization of identical chaotic systems (A, identical chaotic systems (B and nonidentical chaotic systems (A and (B with unknown system parameters. The adaptive controllers for achieving global chaos synchronization of the novel chaotic systems (A and (B have been derived using adaptive control theory and Lyapunov stability theory. MATLAB simulations have been shown to illustrate the novel chaotic systems (A and (B, and also the adaptive synchronization results derived for the novel chaotic systems (A and (B.

  1. Approach for discrimination and quantification of electroactive species: kinetics difference revealed by higher harmonics of Fourier transformed sinusoidal voltammetry.

    Science.gov (United States)

    Fang, Yishan; Huang, Xinjian; Wang, Lishi

    2015-01-06

    Discrimination and quantification of electroactive species are traditionally realized by a potential difference which is mainly determined by thermodynamics. However, the resolution of this approach is limited to tens of millivolts. In this paper, we described an application of Fourier transformed sinusoidal voltammetry (FT-SV) that provides a new approach for discrimination and quantitative evaluation of electroactive species, especially thermodynamic similar ones. Numerical simulation indicates that electron transfer kinetics difference between electroactive species can be revealed by the phase angle of higher order harmonics of FT-SV, and the difference can be amplified order by order. Thus, even a very subtle kinetics difference can be amplified to be distinguishable at a certain order of harmonics. This method was verified with structurally similar ferrocene derivatives which were chosen as the model systems. Although these molecules have very close redox potential (harmonics. The results demonstrated the feasibility and reliability of the method. It was also implied that the combination of the traditional thermodynamic method and this kinetics method can form a two-dimension resolved detection method, and it has the potential to extend the resolution of voltammetric techniques to a new level.

  2. Feasibility and Impact of Implementing Motivational Enhancement Therapy--Cognitive Behavioral Therapy as a Substance Use Treatment Intervention in School-Based Settings

    Science.gov (United States)

    Belur, Vinetha; Dennis, Michael L.; Ives, Melissa L.; Vincent, Robert; Muck, Randolph

    2014-01-01

    The expansion of behavioral health services to school-based health centers under the Affordable Care Act (Public Law 111-148) presents an opportunity to improve access to substance use disorders treatment for youth and reduce their substance use, and emotional, health, and school problems. We explore the feasibility of implementing five to seven…

  3. Development of a theory- and evidence-based intervention to enhance implementation of physical therapy guidelines for the management of low back pain

    NARCIS (Netherlands)

    Rutten, G.M.J.; Harting, J.; Bartholomew, L.K.; Braspenning, J.C.C.; Dolder, R. van; Heijmans, M.F.; Hendriks, E.J.; Kremers, S.P.; Peppen, R.P. van; Rutten, S.T.; Schlief, A.; Vries, N.K. de; Oostendorp, R.A.B.

    2014-01-01

    BACKGROUND: Systematic planning could improve the generally moderate effectiveness of interventions to enhance adherence to clinical practice guidelines. The aim of our study was to demonstrate how the process of Intervention Mapping was used to develop an intervention to address the lack of

  4. Development of a theory- and evidence-based intervention to enhance implementation of physical therapy guidelines for the management of low back pain

    NARCIS (Netherlands)

    Rutten, Geert M.; Harting, Janneke; Bartholomew, Leona K.; Braspenning, Jozé C.; van Dolder, Rob; Heijmans, Marcel Fgj; Hendriks, Erik Jm; Kremers, Stef Pj; van Peppen, Roland Ps; Rutten, Steven Tj; Schlief, Angelique; de Vries, Nanne K.; Oostendorp, Rob Ab

    2014-01-01

    Systematic planning could improve the generally moderate effectiveness of interventions to enhance adherence to clinical practice guidelines. The aim of our study was to demonstrate how the process of Intervention Mapping was used to develop an intervention to address the lack of adherence to the

  5. Implementation of 5E Inquiry Incorporated with Analogy Learning Approach to Enhance Conceptual Understanding of Chemical Reaction Rate for Grade 11 Students

    Science.gov (United States)

    Supasorn, Saksri; Promarak, Vinich

    2015-01-01

    The main purpose of this study was to enhance student understanding of the scientific concepts of chemical reaction rate. Forty-four grade 11 students were the target group. The treatment tools were seven learning plans of 5E inquiry incorporated with an analogy learning approach during 15 hours of class time. In each learning plan, the students…

  6. A national evaluation of a dissemination and implementation initiative to enhance primary care practice capacity and improve cardiovascular disease care: the ESCALATES study protocol

    OpenAIRE

    Cohen, Deborah J.; Balasubramanian, Bijal A.; Gordon, Leah; Marino, Miguel; Ono, Sarah; Solberg, Leif I.; Crabtree, Benjamin F.; Stange, Kurt C.; Davis, Melinda; Miller, William L.; Damschroder, Laura J.; McConnell, K. John; Creswell, John

    2016-01-01

    Background The Agency for Healthcare Research and Quality (AHRQ) launched the EvidenceNOW Initiative to rapidly disseminate and implement evidence-based cardiovascular disease (CVD) preventive care in smaller primary care practices. AHRQ funded eight grantees (seven regional Cooperatives and one independent national evaluation) to participate in EvidenceNOW. The national evaluation examines quality improvement efforts and outcomes for more than 1500 small primary care practices (restricted to...

  7. Analytical solution to the problem of heat transfer in an MHD flow inside a channel with prescribed sinusoidal wall heat flux

    International Nuclear Information System (INIS)

    Zniber, K.; Oubarra, A.; Lahjomri, J.

    2005-01-01

    An MHD laminar flow through a two dimensional channel subjected to a uniform magnetic field and heated at the walls of the conduit over the whole length with a sinusoidal heat flux of vanishing mean value or not, is studied analytically. General expressions of the temperature distribution and of the local and mean Nusselt numbers are obtained by using the technique of linear operators in the case of negligible Joule and viscous dissipation and by taking into account the axial conduction effect. The principal results show that an increase of the local Nusselt number with Hartmann number is observed, and, far from the inlet section, the average heat transfer between the fluid and the walls shows a significant improvement at all values of Hartmann number used when the frequency of the prescribed sinusoidal wall heat flux is increasing in the case of vanishing mean value of the heat flux and this is true especially at low Peclet numbers

  8. Development of a theory- and evidence-based intervention to enhance implementation of physical therapy guidelines for the management of low back pain

    OpenAIRE

    Rutten, Geert M; Harting, Janneke; Bartholomew, Leona K; Braspenning, Jozé C; van Dolder, Rob; Heijmans, Marcel FGJ; Hendriks, Erik JM; Kremers, Stef PJ; van Peppen, Roland PS; Rutten, Steven TJ; Schlief, Angelique; de Vries, Nanne K; Oostendorp, Rob AB

    2014-01-01

    Background Systematic planning could improve the generally moderate effectiveness of interventions to enhance adherence to clinical practice guidelines. The aim of our study was to demonstrate how the process of Intervention Mapping was used to develop an intervention to address the lack of adherence to the national CPG for low back pain by Dutch physical therapists. Methods We systematically developed a program to improve adherence to the Dutch physical therapy guidelines for low back pain. ...

  9. Implementation of resources to support patient physical activity through diabetes centres in Nova Scotia: the effectiveness of enhanced support for exercise participation.

    Science.gov (United States)

    Fowles, Jonathon R; Shields, Chris; d'Entremont, Lisette; McQuaid, Stephanie; Barron, Brittany; Dunbar, Peggy

    2014-12-01

    The purpose of this study was to determine the effectiveness of enhancing support for physical activity counselling and exercise participation at diabetes centres in Nova Scotia on physical activity and exercise behaviours and clinical outcomes in patients with type 2 diabetes mellitus. In all, 180 patients at 8 diabetes centres participated in this observational study. A range of enhanced supports for exercise were offered at these centres. A kinesiologist was added to the diabetes care team to primarily provide extra physical activity counselling and exercise classes. Patient physical activity and exercise levels, efficacy perceptions and mean glycated hemoglobin (A1C) were evaluated at baseline and 6 months. We compared changes in these variables for patients who participated in the enhanced supports versus patients who did not. Participants who attended exercise classes (n=46), increased moderate physical activity by 27% and doubled resistance exercise participation (1.0±1.8 to 2.0±2.1 days per week) whereas those who did not attend exercise classes (n=49) reduced moderate physical activity by 26% and did not change resistance exercise participation (interactions, p=0.04 and p=0.07, respectively). Patients who received resistance band instruction (n=15) from a kinesiologist had reductions in A1C (from 7.5±1.4 to 7.1±1.2; p=0.04), whereas other subgroups did not have significant changes in A1C. Offering enhanced support for exercise at diabetes centres produced improvements in physical activity and exercise in type 2 diabetes patients. Resistance band instruction from a kinesiologist combined with participating in a walking and resistance training program improved glycemic control, which underscores the importance of including exercise professionals in diabetes management. Copyright © 2014 Canadian Diabetes Association. Published by Elsevier Inc. All rights reserved.

  10. Corrigendum to "Sinusoidal potential cycling operation of a direct ethanol fuel cell to improving carbon dioxide yields" [J. Power Sources 268 (5 December 2014) 439-442

    Science.gov (United States)

    Majidi, Pasha; Pickup, Peter G.

    2016-09-01

    The authors regret that Equation (5) is incorrect and has resulted in errors in Fig. 4 and the efficiencies stated on p. 442. The corrected equation, figure and text are presented below. In addition, the title should be 'Sinusoidal potential cycling operation of a direct ethanol fuel cell to improve carbon dioxide yields', and the reversible cell potential quoted on p. 441 should be 1.14 V. The authors would like to apologise for any inconvenience caused.

  11. Cytotoxicity of pyrrolizidine alkaloid in human hepatic parenchymal and sinusoidal endothelial cells: Firm evidence for the reactive metabolites mediated pyrrolizidine alkaloid-induced hepatotoxicity.

    Science.gov (United States)

    Yang, Mengbi; Ruan, Jianqing; Fu, Peter P; Lin, Ge

    2016-01-05

    Pyrrolizidine alkaloids (PAs) widely distribute in plants and can cause hepatic sinusoidal obstruction syndrome (HSOS), which typically presents as a primary sinusoidal endothelial cell damage. It is well-recognized that after ingestion, PAs undergo hepatic cytochromes P450 (CYPs)-mediated metabolic activation to generate dehydropyrrolizidine alkaloids (DHPAs), which are hydrolyzed to dehydroretronecine (DHR). DHPAs and DHR are reactive metabolites having same core pyrrole moiety, and can bind proteins to form pyrrole-protein adducts, which are believed as the primary cause for PA-induced HSOS. However, to date, the direct evidences supporting the toxicity of DHPAs and DHR in the liver, in particular in the sinusoidal endothelial cells, are lacking. Using human hepatic sinusoidal endothelial cells (HSEC) and HepG2 (representing hepatic parenchymal cells), cells that lack CYPs activity, this study determined the direct cytotoxicity of dehydromonocrotaline, a representative DHPA, and DHR, but no cytotoxicity of the intact PA (monocrotaline) in both cell lines, confirming that reactive metabolites mediate PA intoxication. Comparing with HepG2, HSEC had significantly lower basal glutathione (GSH) level, and was significantly more susceptible to the reactive metabolites with severer GSH depletion and pyrrole-protein adducts formation. The toxic potency of two reactive metabolites was also compared. DHPA was more reactive than DHR, leading to severer toxicity. In conclusion, our results unambiguously provided the first direct evidence for the critical role of DHPA and DHR in the reactive metabolites-mediated PA-induced hepatotoxicity, which occurs predominantly in HSEC due to severe GSH depletion and the significant formation of pyrrole-protein adducts in HSEC. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  12. Scattering of atoms by a stationary sinusoidal hard wall: Rigorous treatment in (n+1) dimensions and comparison with the Rayleigh method

    International Nuclear Information System (INIS)

    Goodman, F.O.

    1977-01-01

    A rigorous treatment of the scattering of atoms by a stationary sinusoidal hard wall in (n+1) dimensions is presented, a previous treatment by Masel, Merrill, and Miller for n=1 being contained as a special case. Numerical comparisons are made with the GR method of Garcia, which incorporates the Rayleigh hypothesis. Advantages and disadvantages of both methods are discussed, and it is concluded that the Rayleigh GR method, if handled properly, will probably work satisfactorily in physically realistic cases

  13. Implementation of Gasing Learning in ARCS Learning Strategy to Enhance Students’ Motivation in 9th Grade of Indonesian Junior High-School

    Directory of Open Access Journals (Sweden)

    Pri Ariadi Cahya Dinata

    2017-10-01

    Full Text Available The lack of motivation will affect to the students’ learning outcomes. The research was conducted to enhance the students’ motivation with the Gasing learning in the ARCS learning strategy on the static and dynamic electricity. The specific objectives of this research was to describe effect of the gasing learning on the students' learning motivation. The research consisted of 3 cycles of Hopkin’s Classroom Action Research  Model. Each cycle consists of the plan, the action/the observation, and the reflective. The data of students learning motivation obtained by questionnaires and be analyzed with method of successive interval (MSI. The findings of the research are: (1 the result of questionnaire of ARCS motivation in cycle I was 3.71, cycle II was 3,80, and cycle III was 3,99. These results indicate an increase in student learning motivation; (2 The completeness of students’ learning outcomes in cycle I was 68,18%, in cycle II was 90,90%, and in cycle III was 100%. It can be concluded that the Gasing learning in ARCS strategy can enhances students’motivation on static and dinamic electricity in 9th grade of Indonesian Junior High-School. The Gasing learning can be an alternative for the teachers to enhance students’ motivation in learning physics through the provision of comic media and calculations without formulas.

  14. The Influence of Chordwise Flexibility on the Flow Structure and Streamwise Force of a Sinusoidally Pitching Airfoil

    Science.gov (United States)

    Olson, David Arthur

    Many natural flyers and swimmers need to exploit unsteady mechanisms in order to generate sufficient aerodynamic forces for sustained flight and propulsion. This is, in part, due to the low speed and length scales at which they typically operate. In this low Reynolds number regime, there are many unanswered questions on how existing aerodynamic theory for both steady and unsteady flows can be applied. Additionally, most of these natural flyers and swimmers have deformable wing/fin structures, three dimensional wing planforms, and exhibit complex kinematics during motion. While some biologically-inspired studies seek to replicate these complex structures and kinematics in the laboratory or in numerical simulations, it becomes difficult to draw explicit connections to the existing knowledge base of classical unsteady aerodynamic theory due to the complexity of the problems. In this experimental study, wing kinematics, structure, and planform are greatly simplified to investigate the effect of chordwise flexibility on the streamwise force (thrust) and wake behavior of a sinusoidally pitching airfoil. The study of flexibility in the literature has typically utilized flat plates with varying thicknesses or lengths to change their chordwise flexibility. This choice introduces additional complexities when comparing to the wealth of knowledge originally developed on streamlined aerodynamic shapes. The current study capitalizes on the recent developments in 3D printer technology to create accurate shapes out of materials with varying degrees of flexibility by creating two standard NACA 0009 airfoils: one rigid and one flexible. Each of the two airfoils are sinusoidally pitched about the quarter chord over a range of oscillation amplitudes and frequencies while monitoring the deformation of the airfoil. The oscillation amplitude is selected to be small enough such that leading edge vortices do not form, and the vortical structures in the wake are formed from the trailing

  15. Further characterization of cadmium uptake by rat liver sinusoidal plasma membrane vesicles as a carrier mediated process

    International Nuclear Information System (INIS)

    Eastman, H.B.; Frazier, J.M.

    1990-01-01

    Previously we have reported that cadmium (Cd) transport by rat hepatic sinusoidal plasma membrane vesicles (SPMV's) occurs by both carrier mediated process and simple diffusion. This study was undertaken in order to further characterize the carrier mediated component of Cd transport as a carrier mediated process. Efflux of Cd from SPMV's was measured by first loading the vesicles with 1 μM Cd, containing 109 Cd (Amersham, 0.25 mCi/ml, carrier free) as a tracer, and then diluting the vesicles 1 to 5 into efflux buffer containing 0.25 M sucrose, 150 mM NaCl and 50 mM Tris/HCl (pH 7.4). Under standard conditions, no efflux of Cd from the vesicles was observed. However, the presence of 4mM CdCl 2 or 4.0% BSA in the efflux buffer was able to release 109 Cd from the vesicles. When the vesicles were lysed with 0.1% Triton X-100, approximately 75% of the internalized Cd could be released from the vesicles. Efflux of Cd from the vesicles was also determined to be a temperature dependent process. At 0 C the efflux of Cd from the vesicles, in the presence of a 4 mM CdCl 2 or 4.0% BSA chase, was blocked. The specificity of the carrier mediated component of Cd transport for Cd was investigated by determining whether other metals could compete for Cd uptake. Zinc was a competitive inhibitor of the carrier mediated component of Cd uptake while calcium had no effect on Cd uptake. Using this system, we have demonstrated that one component of Cd transport exhibits the basic characteristics of a carrier mediated process: saturation, reversibility, specificity and temperature dependence

  16. New ways of looking at very small holes - using optical nanoscopy to visualize liver sinusoidal endothelial cell fenestrations

    Science.gov (United States)

    Øie, Cristina I.; Mönkemöller, Viola; Hübner, Wolfgang; Schüttpelz, Mark; Mao, Hong; Ahluwalia, Balpreet S.; Huser, Thomas R.; McCourt, Peter

    2018-02-01

    Super-resolution fluorescence microscopy, also known as nanoscopy, has provided us with a glimpse of future impacts on cell biology. Far-field optical nanoscopy allows, for the first time, the study of sub-cellular nanoscale biological structures in living cells, which in the past was limited to electron microscopy (EM) (in fixed/dehydrated) cells or tissues. Nanoscopy has particular utility in the study of "fenestrations" - phospholipid transmembrane nanopores of 50-150 nm in diameter through liver sinusoidal endothelial cells (LSECs) that facilitate the passage of plasma, but (usually) not blood cells, to and from the surrounding hepatocytes. Previously, these fenestrations were only discernible with EM, but now they can be visualized in fixed and living cells using structured illumination microscopy (SIM) and in fixed cells using single molecule localization microscopy (SMLM) techniques such as direct stochastic optical reconstruction microscopy. Importantly, both methods use wet samples, avoiding dehydration artifacts. The use of nanoscopy can be extended to the in vitro study of fenestration dynamics, to address questions such as the following: are they actually dynamic structures, and how do they respond to endogenous and exogenous agents? A logical further extension of these methodologies to liver research (including the liver endothelium) will be their application to liver tissue sections from animal models with different pathological manifestations and ultimately to patient biopsies. This review will cover the current state of the art of the use of nanoscopy in the study of liver endothelium and the liver in general. Potential future applications in cell biology and the clinical implications will be discussed.

  17. Production of factor VIII by human liver sinusoidal endothelial cells transplanted in immunodeficient uPA mice.

    Directory of Open Access Journals (Sweden)

    Marina E Fomin

    Full Text Available Liver sinusoidal endothelial cells (LSECs form a semi-permeable barrier between parenchymal hepatocytes and the blood. LSECs participate in liver metabolism, clearance of pathological agents, immunological responses, architectural maintenance of the liver and synthesis of growth factors and cytokines. LSECs also play an important role in coagulation through the synthesis of Factor VIII (FVIII. Herein, we phenotypically define human LSECs isolated from fetal liver using flow cytometry and immunofluorescence microscopy. Isolated LSECs were cultured and shown to express endothelial markers and markers specific for the LSEC lineage. LSECs were also shown to engraft the liver when human fetal liver cells were transplanted into immunodeficient mice with liver specific expression of the urokinase-type plasminogen activator (uPA transgene (uPA-NOG mice. Engrafted cells expressed human Factor VIII at levels approaching those found in human plasma. We also demonstrate engraftment of adult LSECs, as well as hepatocytes, transplanted into uPA-NOG mice. We propose that overexpression of uPA provides beneficial conditions for LSEC engraftment due to elevated expression of the angiogenic cytokine, vascular endothelial growth factor. This work provides a detailed characterization of human midgestation LSECs, thereby providing the means for their purification and culture based on their expression of CD14 and CD32 as well as a lack of CD45 expression. The uPA-NOG mouse is shown to be a permissive host for human LSECs and adult hepatocytes, but not fetal hepatoblasts. Thus, these mice provide a useful model system to study these cell types in vivo. Demonstration of human FVIII production by transplanted LSECs encourages further pursuit of LSEC transplantation as a cellular therapy for the treatment of hemophilia A.

  18. Variations in DNA synthesis and mitotic indices in hepatocytes and sinusoid litoral cells of adult intact male mouse along a circadian time span.

    Science.gov (United States)

    Surur, J M; Moreno, F R; Badrán, A F; Llanos, J M

    1985-01-01

    Variations of DNA synthesis (DNAS) and mitotic indices along a circadian time span are described in the hepatocyte and sinusoid litoral cell populations of adult intact male mouse liver. Standardized (light from 0600 to 1800) mice were killed in groups of six to nine animals, every 2-4 hr along a circadian time span. Hepatocytes show significant peaks in the synthesis of DNA and the mitotic activity at 0200 and 1400, respectively. These results correspond to those previously described by us in young immature liver, regenerating liver and hepatomas. The phase differences between these peaks and the differences between their absolute values are discussed. Also considered are the practical consequences of our findings for experimental design. The curve of DNA synthesis of sinusoid litoral cells show a peak at 0200. The mitotic index show a bimodal waveform with peaks at 0800 and 2000. The existence of four different cell populations composing the so called sinusoid litoral cells and also the migration into and out of the liver of some macrophages considered as litoral (Kupffer) cells in our counts, makes interpretation of the curves somewhat complicated and deserves further analysis.

  19. Systems Sustainability: Implementation of Enhanced Maintenance Programs at the Kurchatov Institute, the All-Russian Research Institute of Experimental physics (VNIIEF) and the All-Russian Scientific Institute for Technical Physics (VNIITF)

    International Nuclear Information System (INIS)

    Coppinger, M.; Pikula, M.; Randolph, J.D.; Windham, M.

    1999-01-01

    Implementation of quality maintenance programs is essential to enhancing sustainable continuous operations of United States funded Materials Protection, Control and Accountability (MPC and A) equipment/systems upgrades at various Russian nuclear facilities. An effective maintenance program is expected to provide assurances to both parties for achieving maximum continuous systems operations with minimum down time. To be effective, the program developed must focus on minimum down time for any part of a system. Minimum down time is realized through the implementation of a quality maintenance program that includes preventative maintenance, necessary diagnostic tools, properly trained technical staff, and an in-house inventory of required spare parts for repairing the impacted component of the system. A centralized maintenance management program is logistically essential for the success of this effort because of the large volume of MPC and A equipment/systems installed at those sites. This paper will discuss current programs and conditions at the Russian Research Center-Kurchatov Institute, the All-Russian Scientific Institute for Technical Physics and the All-Russian Research Institute of Experimental Physics and will address those steps necessary to implement an upgraded program at those sites

  20. Hepatic sinusoid is not well-stirred: estimation of the degree of axial mixing by analysis of lobular concentration gradients formed during uptake of thyroxine by the perfused rat liver

    International Nuclear Information System (INIS)

    Weisiger, R.A.; Mendel, C.M.; Cavalieri, R.R.

    1986-01-01

    Two general models have been proposed for predicting the effects of metabolism, protein binding, and plasma flow on the removal of drugs by the liver. These models differ in the degree of plasma mixing assumed to exist within each hepatic sinusoid. The venous equilibrium model treats the sinusoid as a single well-stirred compartment, whereas the sinusoidal model effectively breaks up the sinusoid into a large number of sequentially perfused compartments which do not exchange their contents except through plasma flow. As a consequence, the sinusoidal model, but not the venous equilibrium model, predicts that the concentration of highly extracted drugs will decline as the plasma flows through the hepatic lobule. To determine which of these alternative models best describes the hepatic uptake process, we looked for evidence that concentration gradients are formed during the uptake of [ 125 I]thyroxine by the perfused rat liver. Autoradiography of tissue slices after perfusion of the portal vein at physiologic flow rates with protein-free buffer containing [ 125 I]thyroxine demonstrated a rapid exponential fall in grain density with distance from the portal venule, declining by half for each 8% of the mean length of the sinusoid. Reversing the direction of perfusate flow reversed the direction of the autoradiographic gradients, indicating that they primarily reflect differences in the concentration of thyroxine within the hepatic sinusoids rather than differences in the uptake capacity of portal and central hepatocytes. Analysis of the data using models in which each sinusoid was represented by different numbers of sequentially perfused compartments (1-20) indicated that at least eight compartments were necessary to account for the magnitude of the gradients seen

  1. Defibrotide for Patients with Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome: Interim Results from a Treatment IND Study.

    Science.gov (United States)

    Richardson, Paul G; Smith, Angela R; Triplett, Brandon M; Kernan, Nancy A; Grupp, Stephan A; Antin, Joseph H; Lehmann, Leslie; Shore, Tsiporah; Iacobelli, Massimo; Miloslavsky, Maja; Hume, Robin; Hannah, Alison L; Nejadnik, Bijan; Soiffer, Robert J

    2017-06-01

    Hepatic veno-occlusive disease, or sinusoidal obstruction syndrome (VOD/SOS), is a serious and potentially fatal complication of conditioning for hematopoietic stem cell transplantation (HSCT) or of chemotherapy regimens alone. Defibrotide is a complex mixture of single-stranded polydeoxyribonucleotides that is approved in the United States for treating hepatic VOD/SOS with renal or pulmonary dysfunction post-HSCT and in the European Union, Israel, and South Korea for treating severe hepatic VOD/SOS post-HSCT. Defibrotide was previously available in the United States as an investigational drug through a treatment protocol (treatment IND) study. Interim results of that large, treatment IND study of patients with VOD/SOS and with or without multiorgan dysfunction (MOD; also known as multiorgan failure) are presented here. Defibrotide was administered i.v. at 6.25 mg/kg every 6 hours (25 mg/kg/day), with a recommended treatment duration of at least 21 days. Enrolled patients (n = 681) were diagnosed with VOD/SOS based on Baltimore or modified Seattle criteria or liver biopsy analysis. Among the 573 HSCT recipients, 288 (50.3%; 95% confidence interval [CI], 46.2% to 54.4%) were alive at day +100 post-HSCT. Day +100 survival for the pediatric (≤16 years) and adult (>16 years) subgroups was 54.5% (95% CI, 49.1% to 60.0%; n = 174 of 319) and 44.9% (95% CI, 38.8% to 51.0%; n = 114 of 254), respectively. In the MOD subgroup, 159 of 351 patients (45.3%; 95% CI, 40.1% to 50.5%) of patients were alive at day +100 post-HSCT. Treatment with defibrotide was generally well tolerated, and drug-related toxicities were consistent with previous studies. Adverse events were reported in 69.6% of safety-evaluable patients (399 of 573). Other than VOD/SOS and associated MOD symptoms, the most commonly reported treatment-emergent adverse event was hypotension (13.8%). Day +100 survival results observed in this trial were consistent with results seen in previous trials of

  2. Blood pyrrole-protein adducts as a diagnostic and prognostic index in pyrrolizidine alkaloid-hepatic sinusoidal obstruction syndrome.

    Science.gov (United States)

    Gao, Hong; Ruan, Jianqing Q; Chen, Jie; Li, Na; Ke, Changqiang Q; Ye, Yang; Lin, Ge; Wang, Jiyao Y

    2015-01-01

    The diagnosis of hepatic sinusoidal obstruction syndrome (HSOS) induced by pyrrolizidine alkaloids is mainly based on clinical investigation. There is currently no prognostic index. This study evaluated the quantitative measurement of blood pyrrole-protein adducts (PPAs) as a diagnostic and prognostic index for pyrrolizidine alkaloid-induced HSOS. Suspected drug-induced liver injury patients were prospectively recruited. Blood PPAs were quantitatively measured using ultra-performance liquid chromatography-tandem mass spectrometry. Patients' age, sex, biochemistry test results, and a detailed drug history were recorded. The patients were divided into two groups, ie, those with HSOS induced by pyrrolizidine alkaloid-containing drugs and those with liver injury induced by drugs without pyrrolizidine alkaloids. The relationship between herb administration, clinical outcomes, blood sampling time, and blood PPA concentration in pyrrolizidine alkaloid-associated HSOS patients was analyzed using multiple linear regression analysis. Forty patients met the entry criteria, among whom 23 had pyrrolizidine alkaloid-associated HSOS and 17 had liver injury caused by drugs without pyrrolizidine alkaloids. Among the 23 patients with pyrrolizidine alkaloid-associated HSOS, ten recovered, four developed chronic disease, eight died, and one underwent liver transplantation within 6 months after onset. Blood PPAs were detectable in 24 of 40 patients with concentrations from 0.05 to 74.4 nM. Sensitivity and specificity of the test for diagnosis of pyrrolizidine alkaloid-associated HSOS were 100% (23/23) and 94.1% (23/24), respectively. The positive predictive value was 95.8% and the negative predictive value was 100%, whereas the positive likelihood ratio was 23.81. The level of blood PPAs in the severe group (died or received liver transplantation) was significantly higher than that in the recovery/chronicity group (P=0.004). Blood PPAs measured by ultra-performance liquid

  3. Capturing multi-stage fuzzy uncertainties in hybrid system dynamics and agent-based models for enhancing policy implementation in health systems research.

    Science.gov (United States)

    Liu, Shiyong; Triantis, Konstantinos P; Zhao, Li; Wang, Youfa

    2018-01-01

    In practical research, it was found that most people made health-related decisions not based on numerical data but on perceptions. Examples include the perceptions and their corresponding linguistic values of health risks such as, smoking, syringe sharing, eating energy-dense food, drinking sugar-sweetened beverages etc. For the sake of understanding the mechanisms that affect the implementations of health-related interventions, we employ fuzzy variables to quantify linguistic variable in healthcare modeling where we employ an integrated system dynamics and agent-based model. In a nonlinear causal-driven simulation environment driven by feedback loops, we mathematically demonstrate how interventions at an aggregate level affect the dynamics of linguistic variables that are captured by fuzzy agents and how interactions among fuzzy agents, at the same time, affect the formation of different clusters(groups) that are targeted by specific interventions. In this paper, we provide an innovative framework to capture multi-stage fuzzy uncertainties manifested among interacting heterogeneous agents (individuals) and intervention decisions that affect homogeneous agents (groups of individuals) in a hybrid model that combines an agent-based simulation model (ABM) and a system dynamics models (SDM). Having built the platform to incorporate high-dimension data in a hybrid ABM/SDM model, this paper demonstrates how one can obtain the state variable behaviors in the SDM and the corresponding values of linguistic variables in the ABM. This research provides a way to incorporate high-dimension data in a hybrid ABM/SDM model. This research not only enriches the application of fuzzy set theory by capturing the dynamics of variables associated with interacting fuzzy agents that lead to aggregate behaviors but also informs implementation research by enabling the incorporation of linguistic variables at both individual and institutional levels, which makes unstructured linguistic data

  4. Institutional capacity for health systems research in East and Central Africa schools of public health: enhancing capacity to design and implement teaching programs

    Science.gov (United States)

    2014-01-01

    Background The role of health systems research (HSR) in informing and guiding national programs and policies has been increasingly recognized. Yet, many universities in sub-Saharan African countries have relatively limited capacity to teach HSR. Seven schools of public health (SPHs) in East and Central Africa undertook an HSR institutional capacity assessment, which included a review of current HSR teaching programs. This study determines the extent to which SPHs are engaged in teaching HSR-relevant courses and assessing their capacities to effectively design and implement HSR curricula whose graduates are equipped to address HSR needs while helping to strengthen public health policy. Methods This study used a cross-sectional study design employing both quantitative and qualitative approaches. An organizational profile tool was administered to senior staff across the seven SPHs to assess existing teaching programs. A self-assessment tool included nine questions relevant to teaching capacity for HSR curricula. The analysis triangulates the data, with reflections on the responses from within and across the seven SPHs. Proportions and average of values from the Likert scale are compared to determine strengths and weaknesses, while themes relevant to the objectives are identified and clustered to elicit in-depth interpretation. Results None of the SPHs offer an HSR-specific degree program; however, all seven offer courses in the Master of Public Health (MPH) degree that are relevant to HSR. The general MPH curricula partially embrace principles of competency-based education. Different strengths in curricula design and staff interest in HSR at each SPH were exhibited but a number of common constraints were identified, including out-of-date curricula, face-to-face delivery approaches, inadequate staff competencies, and limited access to materials. Opportunities to align health system priorities to teaching programs include existing networks. Conclusions Each SPH has key

  5. Climate and development: enhancing impact through stronger linkages in the implementation of the Paris Agreement and the Sustainable Development Goals (SDGs).

    Science.gov (United States)

    Gomez-Echeverri, Luis

    2018-05-13

    One of the greatest achievements in the global negotiations of 2015 that delivered the 2030 Agenda for Sustainable Development or Sustainable Development Goals (SDGs) and the Paris Agreement on climate change is that, for the first time, the linkages between climate and development were enshrined in each of the documents. This was done in recognition that climate change and development need to be addressed together in order not only to avoid harmful trade-offs and high costs, particularly for poorer countries, but also to exploit the benefits that come from strengthening these linkages. This review presents some of the latest data that argue for stronger linkages as well as the challenges of implementation which are not only politically and economically related but also include issues such as knowledge gaps, finance and governance. Finally, the review also presents a glimpse at the pathways that will be required to reach the ambitious global temperature targets of the Paris Agreement of less than 2°C above pre-industrial levels with efforts to limit temperature rise even further to 1.5°C. This provides the context for some conclusions and recommendations for policy-makers, including on methodologies for assessing linkages and leveraging them for greater benefit.This article is part of the theme issue 'The Paris Agreement: understanding the physical and social challenges for a warming world of 1.5°C above pre-industrial levels'. © 2018 The Authors.

  6. Climate and development: enhancing impact through stronger linkages in the implementation of the Paris Agreement and the Sustainable Development Goals (SDGs)

    Science.gov (United States)

    Gomez-Echeverri, Luis

    2018-05-01

    One of the greatest achievements in the global negotiations of 2015 that delivered the 2030 Agenda for Sustainable Development or Sustainable Development Goals (SDGs) and the Paris Agreement on climate change is that, for the first time, the linkages between climate and development were enshrined in each of the documents. This was done in recognition that climate change and development need to be addressed together in order not only to avoid harmful trade-offs and high costs, particularly for poorer countries, but also to exploit the benefits that come from strengthening these linkages. This review presents some of the latest data that argue for stronger linkages as well as the challenges of implementation which are not only politically and economically related but also include issues such as knowledge gaps, finance and governance. Finally, the review also presents a glimpse at the pathways that will be required to reach the ambitious global temperature targets of the Paris Agreement of less than 2°C above pre-industrial levels with efforts to limit temperature rise even further to 1.5°C. This provides the context for some conclusions and recommendations for policy-makers, including on methodologies for assessing linkages and leveraging them for greater benefit. This article is part of the theme issue `The Paris Agreement: understanding the physical and social challenges for a warming world of 1.5°C above pre-industrial levels'.

  7. Structure to utilize interventionists' implementation experiences of a family-based behavioral weight management program to enhance the dissemination of the standardized intervention: The TODAY study.

    Science.gov (United States)

    Chadwick, Jennifer Q; Van Buren, Dorothy J; Morales, Elisa; Timpson, Alexandra; Abrams, Ericka L; Syme, Amy; Preske, Jeff; Mireles, Gerardo; Anderson, Barbara; Grover, Nisha; Laffel, Lori

    2017-08-01

    Background For a 2- to 6-year period, interventionists for the TODAY (Treatment Options for type 2 Diabetes in Adolescents and Youth) randomized clinical trial delivered a family-based, behavioral weight-loss program (the TODAY Lifestyle Program) to 234 youth with type 2 diabetes. Interventionists held at least a bachelor's degree in psychology, social work, education, or health-related field and had experience working with children and families, especially from diverse ethnic and socioeconomic backgrounds. This article describes the administrative and organizational structure of the lifestyle program and how the structure facilitated collaboration among study leadership and lifestyle interventionists on the tailoring of the program to best suit the needs of the trial's diverse patient population. Methods During the pilot phase and throughout the duration of the trial, the interventionists' experiences in delivering the intervention were collected in a variety of ways including membership on study committees, survey responses, session audio recordings, and feedback during in-person trainings. Results The experiences of interventionists conveyed to study leadership through these channels resulted in decisions to tailor the lifestyle intervention's delivery location and ways to supplement the standardized educational materials to better address the needs of a diverse patient population. Conclusion The methods used within the TODAY study to encourage and utilize interventionists' experiences while implementing the lifestyle program may be useful to the design of future multi-site, clinical trials seeking to tailor behavioral interventions in a standardized, and culturally and developmentally sensitive manner.

  8. Development of a Plan to Implement Enhanced Geothermal Systems (EGS) in the Animas Valley, New Mexico - Final Report - 07/26/2000 - 02/01/2001

    Energy Technology Data Exchange (ETDEWEB)

    Schochet, Daniel N.; Cunniff, Roy A.

    2001-02-01

    The concept of producing energy from hot dry rock (HDR), originally proposed in 1971 at the Los Alamos National Laboratory, contemplated the generation of electric power by injecting water into artificially created fractures in subsurface rock formations with high heat flow. Recognizing the inherent difficulties associated with HDR, the concept of Enhanced Geothermal Systems was proposed. This embraces the idea that the amount of permeability and fluid in geothermal resources varies across a spectrum, with HDR at one end, and conventional hydrothermal systems at the other. This report provides a concept for development of a ''Combined Technologies Project'' with construction and operation of a 6 MW (net) binary-cycle geothermal power plant that uses both the intermediate-depth hydrothermal system at 1,200 to 3,300 feet and a deeper EGS capable system at 3,000 to 4,000 feet. Two production/injection well pairs will be drilled, one couplet for the hydrothermal system, and one for the E GS system. High-pressure injection may be required to drive fluid through the EGS reservoir from the injection to the production well.

  9. Development of a Plan to Implement Enhanced Geothermal Systems (EGS) in the Animas Valley, New Mexico - Final Report - 07/26/2000 - 02/01/2001; FINAL

    International Nuclear Information System (INIS)

    Schochet, Daniel N.; Cunniff, Roy A.

    2001-01-01

    The concept of producing energy from hot dry rock (HDR), originally proposed in 1971 at the Los Alamos National Laboratory, contemplated the generation of electric power by injecting water into artificially created fractures in subsurface rock formations with high heat flow. Recognizing the inherent difficulties associated with HDR, the concept of Enhanced Geothermal Systems was proposed. This embraces the idea that the amount of permeability and fluid in geothermal resources varies across a spectrum, with HDR at one end, and conventional hydrothermal systems at the other. This report provides a concept for development of a ''Combined Technologies Project'' with construction and operation of a 6 MW (net) binary-cycle geothermal power plant that uses both the intermediate-depth hydrothermal system at 1,200 to 3,300 feet and a deeper EGS capable system at 3,000 to 4,000 feet. Two production/injection well pairs will be drilled, one couplet for the hydrothermal system, and one for the E GS system. High-pressure injection may be required to drive fluid through the EGS reservoir from the injection to the production well

  10. Pilot Implementations

    DEFF Research Database (Denmark)

    Manikas, Maria Ie

    by conducting a literature review. The concept of pilot implementation, although commonly used in practice, is rather disregarded in research. In the literature, pilot implementations are mainly treated as secondary to the learning outcomes and are presented as merely a means to acquire knowledge about a given...... objective. The prevalent understanding is that pilot implementations are an ISD technique that extends prototyping from the lab and into test during real use. Another perception is that pilot implementations are a project multiple of co-existing enactments of the pilot implementation. From this perspective......This PhD dissertation engages in the study of pilot (system) implementation. In the field of information systems, pilot implementations are commissioned as a way to learn from real use of a pilot system with real data, by real users during an information systems development (ISD) project and before...

  11. "Climate change impact on water resources - a challenge for IWRM". BRAHMATWINN - Twinning European and South Asian River Basins to enhance capacity and implement adaptive management approaches

    Science.gov (United States)

    Bartosch, A.; Pechstädt, J.; Müller Schmied, H.; Flügel, W.-A.

    2009-04-01

    BRAHMATWINN addresses climate change impact of the hydrology of two macro-scale river basins having headwaters in alpine mountain massifs. The project will elaborate on the consequential vulnerability of present IWRM and river basin management that have been persistent in these basins during the past decades and will develop tested approaches and technologies for adaptive IWRM and resilience. The overall objective of BRAHMATWINN is to enhance and improve capacity to carry out a harmonized integrated water resources management (IWRM) approach as addressed by the European Water Initiative (EWI) in headwater river systems of alpine mountain massifs in respect to impacts from likely climate change, and to transfer professional IWRM expertise, approaches and tools based on case studies carried out in twinning European and Asian river basins, the Upper Danube River Basin (UDRB) and the Upper Brahmaputra River Basin (UBRB). Sustainable IWRM in river basins of such kind face common problems: (i) floods e.g. during spring melt or heavy storms and droughts during summer; (ii) competing water demands for agriculture, hydropower, rural, urban and industrial development, and the environment; (iii) pollution from point as well as diffuse sources; and (iv) socio-economic and legal issues related to water allocation. Besides those common topics both basins also differ in other issues requiring the adaptation of the IWRM tools; these are for example climate conditions, the density of monitoring network, political framework and trans-boundary conflicts. An IWRM has to consider all water-related issues like the securing of water supply for the population in sufficient quantity and quality, the protection of the ecological function of water bodies and it has to consider the probability of natural hazards like floods and droughts. Furthermore the resource water should be threatened in a way that the needs of future generations can be satisfied. Sustainable development is one of the

  12. Enhancing communication skills for telehealth: development and implementation of a Teach-Back intervention for a national maternal and child health helpline in Australia.

    Science.gov (United States)

    Morony, Suzanne; Weir, Kristie; Duncan, Gregory; Biggs, Janice; Nutbeam, Don; Mccaffery, Kirsten J

    2018-03-07

    Telehealth professionals require advanced communication skills, in part to compensate for lack of visual cues. Teach-Back is a best practice communication technique that has been recommended but not previously evaluated for consumer telehealth. We aimed to implement Teach-Back at a national maternal and child health telephone helpline. We describe the intervention and report telenurse experiences learning to use Teach-Back. We identified barriers (time, knowledge, skills, beliefs) and enablers (self-reflection) to using Teach-Back, and developed a novel training program to address these, guided by the Theoretical Domains Framework. We engaged maternal and child health telenurses to participate in a "communication skills" study. The intervention had two key components: guided self-reflection and a Teach-Back skills workshop. For the duration of the 7-week study nurses completed brief online surveys following each call, reflecting on both the effectiveness of their communication and perceived caller understanding. At the end of each shift they reflected on what worked well. Teach-Back knowledge, skills, and beliefs were addressed in a 2-h workshop using videos, discussion, and role play. We explored nurses' experiences of the intervention in focus groups and interviews; and analysed transcripts and comments from the self-reflection surveys using the Framework method. This study forms part of a larger evaluation conducted in 2016. In total 16 nurses participated: 15 were trained in Teach-Back, and 13 participated in focus groups or interviews. All engaged with both self-reflection and Teach-Back, although to differing extents. Those who reported acquiring Teach-Back skills easily limited themselves to one or two Teach-Back phrases. Nurses reported that actively self-reflecting (including on what they did well) was useful both for developing Teach-Back skills and analysing effectiveness of the techniques. Most wanted more opportunity to learn how their colleagues

  13. WE-FG-206-06: Dual-Input Tracer Kinetic Modeling and Its Analog Implementation for Dynamic Contrast-Enhanced (DCE-) MRI of Malignant Mesothelioma (MPM)

    Energy Technology Data Exchange (ETDEWEB)

    Lee, S; Rimner, A; Hayes, S; Hunt, M; Deasy, J; Zauderer, M; Rusch, V; Tyagi, N [Memorial Sloan Kettering Cancer Center, New York, NY (United States)

    2016-06-15

    Purpose: To use dual-input tracer kinetic modeling of the lung for mapping spatial heterogeneity of various kinetic parameters in malignant MPM Methods: Six MPM patients received DCE-MRI as part of their radiation therapy simulation scan. 5 patients had the epitheloid subtype of MPM, while one was biphasic. A 3D fast-field echo sequence with TR/TE/Flip angle of 3.62ms/1.69ms/15° was used for DCE-MRI acquisition. The scan was collected for 5 minutes with a temporal resolution of 5-9 seconds depending on the spatial extent of the tumor. A principal component analysis-based groupwise deformable registration was used to co-register all the DCE-MRI series for motion compensation. All the images were analyzed using five different dual-input tracer kinetic models implemented in analog continuous-time formalism: the Tofts-Kety (TK), extended TK (ETK), two compartment exchange (2CX), adiabatic approximation to the tissue homogeneity (AATH), and distributed parameter (DP) models. The following parameters were computed for each model: total blood flow (BF), pulmonary flow fraction (γ), pulmonary blood flow (BF-pa), systemic blood flow (BF-a), blood volume (BV), mean transit time (MTT), permeability-surface area product (PS), fractional interstitial volume (vi), extraction fraction (E), volume transfer constant (Ktrans) and efflux rate constant (kep). Results: Although the majority of patients had epitheloid histologies, kinetic parameter values varied across different models. One patient showed a higher total BF value in all models among the epitheloid histologies, although the γ value was varying among these different models. In one tumor with a large area of necrosis, the TK and ETK models showed higher E, Ktrans, and kep values and lower interstitial volume as compared to AATH and DP and 2CX models. Kinetic parameters such as BF-pa, BF-a, PS, Ktrans values were higher in surviving group compared to non-surviving group across most models. Conclusion: Dual-input tracer

  14. Pilot implementation

    DEFF Research Database (Denmark)

    Hertzum, Morten; Bansler, Jørgen P.; Havn, Erling C.

    2012-01-01

    A recurrent problem in information-systems development (ISD) is that many design shortcomings are not detected during development, but first after the system has been delivered and implemented in its intended environment. Pilot implementations appear to promise a way to extend prototyping from...... the laboratory to the field, thereby allowing users to experience a system design under realistic conditions and developers to get feedback from realistic use while the design is still malleable. We characterize pilot implementation, contrast it with prototyping, propose a iveelement model of pilot...... implementation and provide three empirical illustrations of our model. We conclude that pilot implementation has much merit as an ISD technique when system performance is contingent on context. But we also warn developers that, despite their seductive conceptual simplicity, pilot implementations can be difficult...

  15. Hepatic sinusoidal obstruction syndrome during maintenance therapy of childhood acute lymphoblastic leukemia is associated with continuous asparaginase therapy and mercaptopurine metabolites

    DEFF Research Database (Denmark)

    Toksvang, Linea Natalie; De Pietri, Silvia; Nielsen, Stine N.

    2017-01-01

    BACKGROUND: Hepatic sinusoidal obstruction syndrome (SOS) during treatment of childhood acute lymphoblastic leukemia (ALL) has mainly been associated with 6-thioguanine. The occurrence of several SOS cases after the introduction of extended pegylated asparaginase (PEG-asparaginase) therapy...... in the Nordic Society of Paediatric Haematology and Oncology (NOPHO) ALL2008 protocol led us to hypothesize that PEG-asparaginase, combined with other drugs, may trigger SOS during 6-thioguanine-free maintenance therapy. PROCEDURE: In children with ALL treated in Denmark according to the NOPHO ALL2008 protocol...... children receiving PEG-asparaginase biweekly, 29 developed SOS (≥2 criteria: hyperbilirubinemia, hepatomegaly, ascites, weight gain ≥2.5%, unexplained thrombocytopenia

  16. Severe Hepatic Sinusoidal Obstruction Syndrome in a Child Receiving Vincristine, Actinomycin-D, and Cyclophosphamide for Rhabdomyosarcoma: Successful Treatment with Defibrotide.

    Science.gov (United States)

    Choi, Aery; Kang, Young Kyung; Lim, Sewon; Kim, Dong Ho; Lim, Jung Sub; Lee, Jun Ah

    2016-10-01

    Hepatic sinusoidal obstruction syndrome (SOS) is a life-threatening syndrome that generally occurs as a complication after hematopoietic stem cell transplantation or, less commonly, after conventional chemotherapy. Regarding SOS in rhabdomyosarcoma patients who received conventional chemotherapy, the doses of chemotherapeutic agents are associated with the development of SOS. Several cases of SOS in rhabdomyosarcoma patients after receiving chemotherapy with escalated doses of cyclophosphamide have been reported. Here, we report on a 9-year-old female with rhabdomyosarcoma who developed severe SOS after receiving chemotherapy consisting of vincristine, actinomycin-D, and a moderate dose of cyclophosphamide. She was treated successfully with defibrotide without sequelae to the liver.

  17. Blood pyrrole-protein adducts as a diagnostic and prognostic index in pyrrolizidine alkaloid-hepatic sinusoidal obstruction syndrome

    Directory of Open Access Journals (Sweden)

    Gao H

    2015-08-01

    Full Text Available Hong Gao,1,* Jianqing Q Ruan,2,* Jie Chen,1 Na Li,2 Changqiang Q Ke,3 Yang Ye,3–5 Ge Lin,2,4,5 Jiyao Y Wang1,61Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China; 2School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong; 3Shanghai Institute of Materia Medica, Shanghai, People’s Republic of China; 4Joint Research Laboratory for Promoting Globalization of Traditional Chinese Medicines, Shanghai Institute of Materia Medica, 5Chinese University of Hong Kong, Hong Kong; 6Center of Evidence-Based Medicine Fudan University, Shanghai, People’s Republic of China*These authors contributed equally to this work and share first authorship Background: The diagnosis of hepatic sinusoidal obstruction syndrome (HSOS induced by pyrrolizidine alkaloids is mainly based on clinical investigation. There is currently no prognostic index. This study evaluated the quantitative measurement of blood pyrrole-protein adducts (PPAs as a diagnostic and prognostic index for pyrrolizidine alkaloid-induced HSOS.Methods: Suspected drug-induced liver injury patients were prospectively recruited. Blood PPAs were quantitatively measured using ultra-performance liquid chromatography-tandem mass spectrometry. Patients’ age, sex, biochemistry test results, and a detailed drug history were recorded. The patients were divided into two groups, ie, those with HSOS induced by pyrrolizidine alkaloid-containing drugs and those with liver injury induced by drugs without pyrrolizidine alkaloids. The relationship between herb administration, clinical outcomes, blood sampling time, and blood PPA concentration in pyrrolizidine alkaloid-associated HSOS patients was analyzed using multiple linear regression analysis.Results: Forty patients met the entry criteria, among whom 23 had pyrrolizidine alkaloid-associated HSOS and 17 had liver injury caused by drugs without pyrrolizidine alkaloids. Among the 23

  18. Amelioration of cirrhotic portal hypertension by targeted cyclooxygenase-1 siRNA delivery to liver sinusoidal endothelium with polyethylenimine grafted hyaluronic acid.

    Science.gov (United States)

    Lin, Liteng; Cai, Mingyue; Deng, Shaohui; Huang, Wensou; Huang, Jingjun; Huang, Xinghua; Huang, Mingsheng; Wang, Yong; Shuai, Xintao; Zhu, Kangshun

    2017-10-01

    Portal hypertension (PH), a leading cause of mortality in cirrhosis, lacks effective clinical therapeutic strategies. The increased thromboxane A 2 (TXA 2 ), derived primarily from the upregulation of cyclooxygenase-1 (COX-1) in cirrhotic liver sinusoidal endothelial cells (LSECs), is responsible for hepatic endothelial dysfunction and PH. Thus, blocking the COX-1 pathway in cirrhotic LSECs may benefit the treatment of PH. In this study, hyaluronate-graft-polyethylenimine (HA-PEI) was synthesized for the targeted delivery of COX-1 siRNA to LSECs. Compared to non-targeted PEI, HA-PEI mediated much more efficient siRNA delivery, which resulted in potent targeted gene silencing in LSECs. In vivo, HA-PEI notably increased the accumulation of siRNA along the sinusoidal lining of the liver, inhibited over-activation of the COX-1/TXA 2 pathway in LSECs, and successfully reduced portal pressure in cirrhotic mice. These results highlight the potential of HA-PEI complexed siRNA to serve as a LSECs-specific nanomedical system for effective gene therapy in PH. Copyright © 2017 Elsevier Inc. All rights reserved.

  19. Treaty implementation

    International Nuclear Information System (INIS)

    Dunn, L.A.

    1990-01-01

    This paper touches on three aspects of the relationship between intelligence and treaty implementation, a two-way association. First the author discusses the role of intelligence as a basis for compliance monitoring and treaty verification. Second the authors discusses payoffs of intelligence gathering and the intelligence process of treaty implementation, in particular on-site inspection. Third, the author goes in another direction and discusses some of the tensions between the intelligence gathering and treaty-implementation processes, especially with regard to extensive use of on-site inspection, such as we are likely to see in monitoring compliance of future arms control treaties

  20. A Comparative Study on Pulse Sinusoidal High Frequency Voltage Injection and INFORM Methods for PMSM Position Sensorless Control

    DEFF Research Database (Denmark)

    Ni, Ronggang; Lu, Kaiyuan; Blaabjerg, Frede

    2016-01-01

    and Indirect Flux detection by On-line Reactance Measurement (INFORM) method in the α-β reference frame. Implementation methods are deliberated in detail and the position estimation error caused by magnetic field distorsion is also discussed. Experiments using a commercial PMSM are carried out...

  1. Prep-ME Software Implementation and Enhancement

    Science.gov (United States)

    2017-09-01

    Highway agencies across the United States are moving from empirical design procedures towards the mechanistic-empirical (ME) based pavement design. Even though the Pavement ME Design presents a new paradigm shift with several dramatic improvements, i...

  2. Theoretical Design of a Depolarized Interferometric Fiber-Optic Gyroscope (IFOG on SMF-28 Single-Mode Standard Optical Fiber Based on Closed-Loop Sinusoidal Phase Modulation with Serrodyne Feedback Phase Modulation Using Simulation Tools for Tactical and Industrial Grade Applications

    Directory of Open Access Journals (Sweden)

    Ramón José Pérez

    2016-04-01

    Full Text Available This article presents, by means of computational simulation tools, a full analysis and design of an Interferometric Fiber-Optic Gyroscope (IFOG prototype based on a closed-loop configuration with sinusoidal bias phase- modulation. The complete design of the different blocks, optical and electronic, is presented, including some novelties as the sinusoidal bias phase-modulation and the use of an integrator to generate the serrodyne phase-modulation signal. The paper includes detailed calculation of most parameter values, and the plots of the resulting signals obtained from simulation tools. The design is focused in the use of a standard single-mode optical fiber, allowing a cost competitive implementation compared to commercial IFOG, at the expense of reduced sensitivity. The design contains an IFOG model that accomplishes tactical and industrial grade applications (sensitivity ≤ 0.055 °/h. This design presents two important properties: (1 an optical subsystem with advanced conception: depolarization of the optical wave by means of Lyot depolarizers, which allows to use a sensing coil made by standard optical fiber, instead by polarization maintaining fiber, which supposes consequent cost savings and (2 a novel and simple electronic design that incorporates a linear analog integrator with reset in feedback chain, this integrator generating a serrodyne voltage-wave to apply to Phase-Modulator (PM, so that it will be obtained the interferometric phase cancellation. This particular feedback design with sawtooth-wave generated signal for a closed-loop configuration with sinusoidal bias phase modulation has not been reported till now in the scientific literature and supposes a considerable simplification with regard to previous designs based on similar configurations. The sensing coil consists of an 8 cm average diameter spool that contains 300 m of standard single-mode optical-fiber (SMF-28 type realized by quadrupolar winding. The working

  3. Theoretical Design of a Depolarized Interferometric Fiber-Optic Gyroscope (IFOG) on SMF-28 Single-Mode Standard Optical Fiber Based on Closed-Loop Sinusoidal Phase Modulation with Serrodyne Feedback Phase Modulation Using Simulation Tools for Tactical and Industrial Grade Applications.

    Science.gov (United States)

    Pérez, Ramón José; Álvarez, Ignacio; Enguita, José María

    2016-04-27

    This article presents, by means of computational simulation tools, a full analysis and design of an Interferometric Fiber-Optic Gyroscope (IFOG) prototype based on a closed-loop configuration with sinusoidal bias phase- modulation. The complete design of the different blocks, optical and electronic, is presented, including some novelties as the sinusoidal bias phase-modulation and the use of an integrator to generate the serrodyne phase-modulation signal. The paper includes detailed calculation of most parameter values, and the plots of the resulting signals obtained from simulation tools. The design is focused in the use of a standard single-mode optical fiber, allowing a cost competitive implementation compared to commercial IFOG, at the expense of reduced sensitivity. The design contains an IFOG model that accomplishes tactical and industrial grade applications (sensitivity ≤ 0.055 °/h). This design presents two important properties: (1) an optical subsystem with advanced conception: depolarization of the optical wave by means of Lyot depolarizers, which allows to use a sensing coil made by standard optical fiber, instead by polarization maintaining fiber, which supposes consequent cost savings and (2) a novel and simple electronic design that incorporates a linear analog integrator with reset in feedback chain, this integrator generating a serrodyne voltage-wave to apply to Phase-Modulator (PM), so that it will be obtained the interferometric phase cancellation. This particular feedback design with sawtooth-wave generated signal for a closed-loop configuration with sinusoidal bias phase modulation has not been reported till now in the scientific literature and supposes a considerable simplification with regard to previous designs based on similar configurations. The sensing coil consists of an 8 cm average diameter spool that contains 300 m of standard single-mode optical-fiber (SMF-28 type) realized by quadrupolar winding. The working wavelength will be

  4. Elusive Implementation

    DEFF Research Database (Denmark)

    Heering Holt, Ditte; Rod, Morten Hulvej; Waldorff, Susanne Boch

    2018-01-01

    in health. However, despite growing support for intersectoral policymaking, implementation remains a challenge. Critics argue that public health has remained naïve about the policy process and a better understanding is needed. Based on ethnographic data, this paper conducts an in-depth analysis of a local......: On the basis of an explorative study among ten Danish municipalities, we conducted an ethnographic study of the development of a municipal-wide implementation strategy for the intersectoral health policy of a medium-sized municipality. The main data sources consist of ethnographic field notes from participant...

  5. The role of computer-aided 3D surgery and stereolithographic modelling for vector orientation in premaxillary and trans-sinusoidal maxillary distraction osteogenesis.

    Science.gov (United States)

    Varol, Altan; Basa, Selçuk

    2009-06-01

    Maxillary distraction osteogenesis is a challenging procedure when it is performed with internal submerged distractors due to obligation of setting accurate distraction vectors. Five patients with severe maxillary retrognathy were planned with Mimics 10.01 CMF and Simplant 10.01 software. Distraction vectors and rods of distractors were arranged in 3D environment and on STL models. All patients were operated under general anaesthesia and complete Le Fort I downfracture was performed. All distractions were performed according to orientated vectors. All patients achieved stable occlusion and satisfactory aesthetic outcome at the end of the treatment period. Preoperative bending of internal maxillary distractors prevents significant loss of operation time. 3D computer-aided surgical simulation and model surgery provide accurate orientation of distraction vectors for premaxillary and internal trans-sinusoidal maxillary distraction. Combination of virtual surgical simulation and stereolithographic models surgery can be validated as an effective method of preoperative planning for complicated maxillofacial surgery cases.

  6. Implementation Politics

    DEFF Research Database (Denmark)

    Hegland, Troels Jacob; Raakjær, Jesper

    2008-01-01

    level are supplemented or even replaced by national priorities. The chapter concludes that in order to capture the domestic politics associated with CFP implementation in Denmark, it is important to understand the policy process as a synergistic interaction between dominant interests, policy alliances...

  7. Implementation Strategy

    Science.gov (United States)

    1983-01-01

    Meeting the identified needs of Earth science requires approaching EOS as an information system and not simply as one or more satellites with instruments. Six elements of strategy are outlined as follows: implementation of the individual discipline missions as currently planned; use of sustained observational capabilities offered by operational satellites without waiting for the launch of new mission; put first priority on the data system; deploy an Advanced Data Collection and Location System; put a substantial new observing capability in a low Earth orbit in such a way as to provide for sustained measurements; and group instruments to exploit their capabilities for synergism; maximize the scientific utility of the mission; and minimize the costs of implementation where possible.

  8. Implementing Pseudonymity

    Directory of Open Access Journals (Sweden)

    Miranda Mowbray

    2006-03-01

    Full Text Available I will give an overview of some technologies that enable pseudonymity - allowing individuals to reveal or prove information about themselves to others without revealing their full identity. I will describe some functionalities relating to pseudonymity that can be implemented, and some that cannot. My intention is to present enough of the mathematics that underlies technology for pseudonymity to show that it is indeed possible to implement some functionalities that at first glance may appear impossible. In particular, I will show that several of the intended functions of the UK national ID could be provided in a pseudonymous fashion, allowing greater privacy. I will also outline some technology developed at HP Labs which ensures that users’ personal data is released only to software that has been checked to conform to their preferred privacy policies.

  9. Fusion Implementation

    International Nuclear Information System (INIS)

    Schmidt, J.A.

    2002-01-01

    If a fusion DEMO reactor can be brought into operation during the first half of this century, fusion power production can have a significant impact on carbon dioxide production during the latter half of the century. An assessment of fusion implementation scenarios shows that the resource demands and waste production associated with these scenarios are manageable factors. If fusion is implemented during the latter half of this century it will be one element of a portfolio of (hopefully) carbon dioxide limiting sources of electrical power. It is time to assess the regional implications of fusion power implementation. An important attribute of fusion power is the wide range of possible regions of the country, or countries in the world, where power plants can be located. Unlike most renewable energy options, fusion energy will function within a local distribution system and not require costly, and difficult, long distance transmission systems. For example, the East Coast of the United States is a prime candidate for fusion power deployment by virtue of its distance from renewable energy sources. As fossil fuels become less and less available as an energy option, the transmission of energy across bodies of water will become very expensive. On a global scale, fusion power will be particularly attractive for regions separated from sources of renewable energy by oceans

  10. The use of enhanced recovery after surgery (ERAS) principles in Scottish orthopaedic units--an implementation and follow-up at 1 year, 2010-2011: a report from the Musculoskeletal Audit, Scotland.

    Science.gov (United States)

    Scott, Nicholas B; McDonald, David; Campbell, Jane; Smith, Richard D; Carey, A Kate; Johnston, Ian G; James, Kate R; Breusch, Steffen J

    2013-01-01

    To establish whether a nationally guided programme can lead to more widespread implementation of enhanced recovery after surgery (ERAS), a well-established optimised care pathway for lower limb arthroplasty. In 2010, National Services Scotland's Musculoskeletal Audit was asked to perform a 'snapshot' audit of the current peri-operative management of patients undergoing total hip and knee arthroplasty in all 22 Scottish orthopaedic units with an identical follow-up audit in 2011 after input and support from the national steering group. Audit 1 and audit 2 involved 1,345 and 1,278 patients, respectively. The number of Scottish units that developed an ERAS programme increased from 8 (36 %) to 15 (68 %). Units that included more ERAS patients had earlier mobilisation rates (146/474, 36 % ERAS patients mobilised same day vs. 34/873, 4 % non-ERAS; n = 22 units, r = 0.55, p = 0.008) and shorter post-operative length of stay (median 4 days vs. ERAS, 5 days non-ERAS, n = 22 units, r = -0.64, p = 0.001). ERAS knee arthroplasty patients had lower blood transfusion rates (5/205, 2 % vs. 51/399, 13 %, n = 22 units, r = -0.62, p = 0.002). Units that restricted the use of IV fluids post-operatively had higher early mobilisation rates (n = 22 units, r = 0.48, p = 0.03) and shorter post-operative length of stay (n = 22 units, r = -0.56, p = 0.007). Reduced use of patient-controlled analgesia was also associated with earlier mobilisation (n = 22 units, r = 0.49, p = 0.02) and shorter length of stay (n = 22 units, r = -0.39, p = 0.07). Urinary catheterisation rates also dropped from 468/1,345 (35 %) in 2010 to 337/1,278 (26 %) in 2011 (n = 22 units, z = 2.19, p = 0.03). A clinically guided and nationally supported process has proven highly successful in achieving a further uptake of enhanced recovery principles after lower limb arthroplasty in Scotland, which has resulted in clinical benefits to patients and reduced length of hospital stay.

  11. Coeur d'Alene Tribe Fisheries Program Research, Monitoring and Evaluation Plan; Implementation of Fisheries Enhancement Opportunities on the Coeur d'Alene Reservation, 1997-2002 Technical Report.

    Energy Technology Data Exchange (ETDEWEB)

    Vitale, Angelo; Lamb, Dave; Peters, Ronald

    2002-11-01

    channel forms. In addition, ponds have been constructed to trap sediment from rill and gully erosion associated with agricultural practices, and to provide flow enhancement and ameliorate elevated stream temperatures during the summer base flow period. The implementation of restoration efforts that target the key habitats and lifestages for resident westslope cutthroat trout on the Coeur d'Alene Reservation is one means the Tribe is using to partially mitigate for lost anadromous fisheries. In this context, restoration is consistent with the definition provided by Ebersole et al. (1997), who described stream restoration as the reexpression of habitat capacity in a stream system. At the reach scale, habitat capacity is affected by biotic (e.g., riparian vegetation) and physical (e.g., flooding) processes. Superimposed on the natural biotic and physical processes are anthropogenic stressors (e.g., logging, roads and grazing) that suppress habitat capacity and can result in simplified, degraded stream reaches. The effectiveness of habitat restoration, measured as an increase in native trout abundance, is dependent on reducing limiting factors (e.g., passage barriers, high water temperatures, sediment transport from source areas) in areas that are critical for spawning and rearing lifestages. This plan outlines a monitoring strategy to help determine the effectiveness of specific restoration/enhancement treatments and to track the status of trout populations in four target watersheds.

  12. [Implementing evidence and implementation research: two different and prime realities].

    Science.gov (United States)

    Rumbo Prieto, José María; Martínez Ques, Ángel Alfredo; Sobrido Prieto, María; Raña Lama, Camilo Daniel; Vázquez Campo, Miriam; Braña Marcos, Beatriz

    Scientific research can contribute to more efficient health care, enhance care quality and safety of persons. In order for this to happen, the knowledge gained must be put into practice. Implementation is known as the introduction of a change or innovation to daily practice, which requires effective communication and the elimination of barriers that hinder this process. Best practice implementation experiences are being used increasingly in the field of nursing. The difficulty in identifying the factors that indicate the success or failure of implementation has led to increased studies to build a body of differentiated knowledge, recognized as implementation science or implementation research. Implementation research is the scientific study whose objective is the adoption and systematic incorporation of research findings into clinical practice to improve the quality and efficiency of health services. The purpose of implementation research is to improve the health of the population through equitable and effective implementation of rigorously evaluated scientific knowledge, which involves gathering the evidence that has a positive impact on the health of the community. In this text, we set out the characteristics of nursing implementation research, providing a synthesis of different methods, theories, key frameworks and implementation strategies, along with the terminology proposed for greater conceptual clarity. Copyright © 2016 Elsevier España, S.L.U. All rights reserved.

  13. Hepatitis C virus core protein induces dysfunction of liver sinusoidal endothelial cell by down-regulation of silent information regulator 1.

    Science.gov (United States)

    Sun, Li-Jie; Yu, Jian-Wu; Shi, Yu-Guang; Zhang, Xiao-Yu; Shu, Meng-Ni; Chen, Mo-Yang

    2018-05-01

    Hepatic fibrosis is a frequent feature of chronic hepatitis C virus (HCV) infection. Some evidence has suggested the potential role of silent information regulator 1 (SIRT1) in organ fibrosis. The aim of this study was to investigate the effect of HCV core protein on expression of SIRT1 of liver sinusoidal endothelial cell (LSEC) and function of LSEC. LSECs were co-cultured with HepG2 cells or HepG2 cells expressing HCV core protein and LSECs cultured alone were used as controls. After co-culture, the activity and expression levels of mRNA and protein of SIRT1 in LSEC were detected by a SIRT1 fluorometric assay kit, real time-PCR (RT-PCR), Western blot, respectively. The levels of adiponectin receptor 2 (AdipoR2), endothelial nitric oxide synthase (eNOS) and vascular endothelial growth factor (VEGF) were measured by Western blot. Cluster of differentiation 31 (CD31), CD14, and von Willebrand factor (vWf) of LSECs was performed by flow cytometry. The level of reactive oxygen species (ROS) was assayed. Malondialdehyde (MDA), superoxide dismutase (SOD), adiponectin, nitric oxide (NO), and endothelin-1 (ET-1) levels in the co-culture supernatant were measured. The co-culture supernatant was then used to cultivate LX-2 cells. The levels of α-smooth muscle actin (ASMA) and transforming growth factor-β1 (TGF-β1) protein in LX-2 cells were measured by Western blot. Compared with LSEC co-cultured with HepG2 cells group, in LSEC co-cultured with HepG2-core cells group, the activity and expression level of mRNA and protein of SIRT1 reduced; the level of adiponectin reduced and the expression level of AdipoR2 protein decreased; ROS levels increased; the expression level of eNOS, VEGF protein decreased; and the expression level of CD14 decreased; the expression level of vWf and CD31 increased; NO and SOD levels decreased; whereas ET-1 and MDA levels increased; the levels of ASMA and TGF-β1 protein in LX-2 cells increased. SIRT1 activator improved the above-mentioned changes

  14. Sinusoidal obstruction syndrome (SOS) related to chemotherapy for colorectal liver metastases: factors predictive of severe SOS lesions and protective effect of bevacizumab.

    Science.gov (United States)

    Hubert, Catherine; Sempoux, Christine; Humblet, Yves; van den Eynde, Marc; Zech, Francis; Leclercq, Isabelle; Gigot, Jean-François

    2013-11-01

    The most frequent presentation of chemotherapy-related toxicity in colorectal liver metastases (CRLM) is sinusoidal obstruction syndrome (SOS). The purpose of the present study was to identify preoperative factors predictive of SOS and to establish associations between type of chemotherapy and severity of SOS. A retrospective study was carried out in a tertiary academic referral hospital. Patients suffering from CRLM who had undergone resection of at least one liver segment were included. Grading of SOS on the non-tumoral liver parenchyma was accomplished according to the Rubbia-Brandt criteria. A total of 151 patients were enrolled and divided into four groups according to the severity of SOS (grades 0-3). Multivariate analysis identified oxaliplatin and 5-fluorouracil as chemotherapeutic agents responsible for severe SOS lesions (P SOS lesions (P = 0.005). Univariate analysis identified the score on the aspartate aminotransferase : platelets ratio index (APRI) as the most significant biological factor predictive of severe SOS lesions. Splenomegaly is also significantly associated with the occurrence of severe SOS lesions. The APRI score and splenomegaly are effective as factors predictive of SOS. Bevacizumab has a protective effect against SOS. © 2013 International Hepato-Pancreato-Biliary Association.

  15. Long live the liver: immunohistochemical and stereological study of hepatocytes, liver sinusoidal endothelial cells, Kupffer cells and hepatic stellate cells of male and female rats throughout ageing.

    Science.gov (United States)

    Marcos, Ricardo; Correia-Gomes, Carla

    2016-12-01

    Male/female differences in enzyme activity and gene expression in the liver are known to be attenuated with ageing. Nevertheless, the effect of ageing on liver structure and quantitative cell morphology remains unknown. Male and female Wistar rats aged 2, 6, 12 and 18 months were examined by means of stereological techniques and immunohistochemical tagging of hepatocytes (HEP), liver sinusoidal endothelial cells (LSEC), Kupffer cells (KC) and hepatic stellate cells (HSC) in order to assess the total number and number per gram of these cells throughout life. The mean cell volume of HEP and HSC, the lobular position and the collagen content of the liver were also evaluated with stereological techniques. The number per gram of HSC was similar for both genders and was maintained throughout ageing. The mean volume of HSC was also conserved but differences in the cell body and lobular location were observed. Statistically significant gender differences in HEP were noted in young rats (females had smaller and more binucleated HEP) but were attenuated with ageing. The same occurred for KC and LSEC, since the higher number per gram in young females disappeared in older animals. Liver collagen increased with ageing but only in males. Thus, the numbers of these four cell types are related throughout ageing, with well-defined cell ratios. The shape and lobular position of HSC change with ageing in both males and females. Gender dimorphism in HEP, KC and LSEC of young rat liver disappears with ageing.

  16. Kruppel-like factor 2 inhibit the angiogenesis of cultured human liver sinusoidal endothelial cells through the ERK1/2 signaling pathway

    Energy Technology Data Exchange (ETDEWEB)

    Zeng, Xiao-Qing, E-mail: zeng.xiaoqing@zs-hospital.sh.cn [Department of Gastroenterology of Zhongshan Hospital, Fudan University, Shanghai (China); Li, Na, E-mail: Linala.2009@163.com [Department of Gastroenterology of Zhongshan Hospital, Fudan University, Shanghai (China); Pan, Du-Yi, E-mail: lasikesmi@hotmail.com [Department of Gastroenterology of Zhongshan Hospital, Fudan University, Shanghai (China); Miao, Qing, E-mail: sadsadvenus@163.com [Department of Gastroenterology of Zhongshan Hospital, Fudan University, Shanghai (China); Ma, Gui-Fen, E-mail: ma.guifen@zs-hospital.sh.cn [Department of Gastroenterology of Zhongshan Hospital, Fudan University, Shanghai (China); Liu, Yi-Mei, E-mail: liuyimei1988@163.com [Department of Gastroenterology of Zhongshan Hospital, Fudan University, Shanghai (China); Tseng, Yu-Jen, E-mail: dianatseng14@gmail.com [Department of Gastroenterology of Zhongshan Hospital, Fudan University, Shanghai (China); Li, Feng, E-mail: li.feng2@zs-hospital.sh.cn [Department of Gastroenterology of Zhongshan Hospital, Fudan University, Shanghai (China); Xu, Li-Li, E-mail: xu.lili3@zs-hospital.sh.cn [Department of Gastroenterology of Zhongshan Hospital, Fudan University, Shanghai (China); Chen, Shi-Yao, E-mail: chen.shiyao@zs-hospital.sh.cn [Department of Gastroenterology of Zhongshan Hospital, Fudan University, Shanghai (China); Institute of Endoscopic Research of Zhongshan Hospital, Fudan University, Shanghai (China)

    2015-09-04

    Kruppel-like factor 2 (KLF2) is a crucial anti-angiogenic factor. However, its precise role in hepatic angiogenesis induced by liver sinusoidal endothelial cells (LSECs) remain unclear. This study was aimed to evaluate the effect of KLF2 on angiogenesis of LSECs and to explore the corresponding mechanism. Cultured human LSECs were infected with different lentiviruses to overexpress or suppress KLF2 expression. The CCK-8 assay, transwell migration assay and tube formation test, were used to investigate the roles of KLF2 in the proliferation, migration and vessel tube formation of LSECs, respectively. The expression and phosphorylation of ERK1/2 were detected by western blot. We discovered that the up-regulation of KLF2 expression dramatically inhibited proliferation, migration and tube formation in treated LSECs. Correspondingly, down-regulation of KLF2 expression significantly promoted proliferation, migration and tube formation in treated LSECs. Additionally, KLF2 inhibited the phosphorylation of ERK1/2 pathway, followed by the function of KLF2 in the angiogenesis of LSECs disrupted. In conclusion, KLF2 suppressed the angiogenesis of LSECs through inhibition of cell proliferation, migration, and vessel tube formation. These functions of KLF2 may be mediated through the ERK1/2 signaling pathway. - Highlights: • Overexpression of KLF2 inhibits the proliferation and migration of LSECs. • Overexpression of KLF2 inhibits the angiogenesis of LSECs. • ERK1/2 signaling pathway involved in the anti-angiogenic process of KLF2 on LSECs.

  17. Post Fukushima safety enhancements in Indian PHWRS

    International Nuclear Information System (INIS)

    Ramasomayajulu, M.; Khot, Pankaj; Chauhan, Ashok

    2016-01-01

    Fukushima event was reviewed in Nuclear Power Corporation of India (NPCIL) and based on these reviews, safety enhancements were identified for Indian PHWRs. Safety enhancements such as additional emergency power sources, enhanced onsite water inventories, external water injection arrangements (Hook up points), measures related to hydrogen management, containment venting provision, seismic trip, mobile pumps, onsite emergency support Centre. These safety enhancements were reviewed by the regulatory body (Atomic Energy Regulatory Board, AERB) and were approved for implementation. Most of these are either implemented or in the advance stage of implementation. The paper elaborates above safety enhancements implemented post Fukushima accident; and preparedness to use these provisions. (author)

  18. Significance of power average of sinusoidal and non-sinusoidal ...

    Indian Academy of Sciences (India)

    2016-06-08

    Jun 8, 2016 ... PG & Research Department of Physics, Nehru Memorial College (Autonomous),. Puthanampatti .... for long time intervals, the periodic or chaotic behaviour ..... square force (short dashed line), sawtooth force (long dashed.

  19. MDSplus objects-Python implementation

    Energy Technology Data Exchange (ETDEWEB)

    Fredian, T., E-mail: twf@psfc.mit.ed [Massachusetts Institute of Technology, Plasma Science and Fusion Center, NW17-268, 175 Albany Street, Cambridge, MA 02139 (United States); Stillerman, J. [Massachusetts Institute of Technology, Plasma Science and Fusion Center, NW17-268, 175 Albany Street, Cambridge, MA 02139 (United States); Manduchi, G. [Consorzio RFX, Euratom-ENEA Association, Corso Stati Uniti 4, Padova 35127 (Italy)

    2010-07-15

    MDSplus is a data acquisition and analysis software package used widely throughout the international fusion research community. During the past year, an important set of enhancements were designed under the project name of 'MDSobjects' which would provide a common, powerful application programming interface (API) to MDSplus in programming languages with object-oriented capabilities. This paper will discuss the Python language implementation of this API and some of the capabilities that this implementation provides for data storage and retrieval using the MDSplus system. We have implemented a new MDSplus Python module which exposes the MDSplus objects features to the language. The internal MDSplus programming language, TDI, has also been enhanced to be able to invoke Python commands from the TDI language. Now that Python is aware of the complex data structures in MDSplus such as Signals, the language becomes a very good candidate for applications ranging from data acquisition device support to analysis and visualization.

  20. MDSplus objects-Python implementation

    International Nuclear Information System (INIS)

    Fredian, T.; Stillerman, J.; Manduchi, G.

    2010-01-01

    MDSplus is a data acquisition and analysis software package used widely throughout the international fusion research community. During the past year, an important set of enhancements were designed under the project name of 'MDSobjects' which would provide a common, powerful application programming interface (API) to MDSplus in programming languages with object-oriented capabilities. This paper will discuss the Python language implementation of this API and some of the capabilities that this implementation provides for data storage and retrieval using the MDSplus system. We have implemented a new MDSplus Python module which exposes the MDSplus objects features to the language. The internal MDSplus programming language, TDI, has also been enhanced to be able to invoke Python commands from the TDI language. Now that Python is aware of the complex data structures in MDSplus such as Signals, the language becomes a very good candidate for applications ranging from data acquisition device support to analysis and visualization.

  1. To elaborate and implement a brochure of reading strategies with a focus on andragogy “Reading is learning” in order to enhance Reading skills in ESL students of the B1+ level of the Language Centre at Universidad Técnica de Ambato, academic period 2015

    OpenAIRE

    Hidalgo Camacho, Cynthia Soledad

    2016-01-01

    This research work: to elaborate and to implement a brochure with Reading strategies “Reading is learning”, aims to enhance Reading comprehension in students from the B1+ level of English, at the languages center in Universidad Técnica De Ambato. The students’ population groups found here are adults from 18 to 40 years of age. Although reading can definitely be affected by some personal factors such as formal educational background, frequency of reading, types of texts used, attitude of th...

  2. Earlier defibrotide initiation post-diagnosis of veno-occlusive disease/sinusoidal obstruction syndrome improves Day +100 survival following haematopoietic stem cell transplantation.

    Science.gov (United States)

    Richardson, Paul G; Smith, Angela R; Triplett, Brandon M; Kernan, Nancy A; Grupp, Stephan A; Antin, Joseph H; Lehmann, Leslie; Miloslavsky, Maja; Hume, Robin; Hannah, Alison L; Nejadnik, Bijan; Soiffer, Robert J

    2017-07-01

    Hepatic veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a progressive, potentially fatal complication of conditioning for haematopoietic stem cell transplant (HSCT). The VOD/SOS pathophysiological cascade involves endothelial-cell activation and damage, and a prothrombotic-hypofibrinolytic state. Severe VOD/SOS (typically characterized by multi-organ dysfunction) may be associated with >80% mortality. Defibrotide is approved for treating severe hepatic VOD/SOS post-HSCT in the European Union, and for hepatic VOD/SOS with renal or pulmonary dysfunction post-HSCT in the United States. Previously, defibrotide (25 mg/kg/day in 4 divided doses for a recommended ≥21 days) was available through an expanded-access treatment protocol for patients with VOD/SOS. Data from this study were examined post-hoc to determine if the timing of defibrotide initiation post-VOD/SOS diagnosis affected Day +100 survival post-HSCT. Among 573 patients, defibrotide was started on the day of VOD/SOS diagnosis in approximately 30%, and within 7 days in >90%. The relationship between Day +100 survival and treatment initiation before/after specific days post-diagnosis showed superior survival when treatment was initiated closer to VOD/SOS diagnosis with a statistically significant trend over time for better outcomes with earlier treatment initiation (P defibrotide should not be delayed after diagnosis of VOD/SOS. © 2017 The Authors. British Journal of Haematology published by John Wiley & Sons Ltd.

  3. Final results from a defibrotide treatment-IND study for patients with hepatic veno-occlusive disease/sinusoidal obstruction syndrome.

    Science.gov (United States)

    Kernan, Nancy A; Grupp, Stephan; Smith, Angela R; Arai, Sally; Triplett, Brandon; Antin, Joseph H; Lehmann, Leslie; Shore, Tsiporah; Ho, Vincent T; Bunin, Nancy; Iacobelli, Massimo; Liang, Wei; Hume, Robin; Tappe, William; Soiffer, Robert; Richardson, Paul

    2018-05-16

    Hepatic veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a potentially life-threatening complication of haematopoietic stem cell transplant (HSCT) conditioning and chemotherapy. Defibrotide is approved for treatment of hepatic VOD/SOS with pulmonary or renal dysfunction [i.e., multi-organ dysfunction (MOD)] after HSCT in the United States and severe VOD/SOS after HSCT in patients aged older than 1 month in the European Union. Defibrotide was available as an investigational drug by an expanded-access treatment programme (T-IND; NCT00628498). In the completed T-IND, the Kaplan-Meier estimated Day +100 survival for 1000 patients with documented defibrotide treatment after HSCT was 58·9% [95% confidence interval (CI), 55·7-61·9%]. Day +100 survival was also analysed by age and MOD status, and post hoc analyses were performed to determine Day +100 survival by transplant type, timing of VOD/SOS onset (≤21 or >21 days) and timing of defibrotide treatment initiation after VOD/SOS diagnosis. Day +100 survival in paediatric patients was 67·9% (95% CI, 63·8-71·6%) and 47·1% (95% CI, 42·3-51·8%) in adults. All patient subgroups without MOD had higher Day +100 survival than those with MOD; earlier defibrotide initiation was also associated with higher Day +100 survival. The safety profile of defibrotide in the completed T-IND study was similar to previous reports. © 2018 The Authors. British Journal of Haematology published by John Wiley & Sons Ltd.

  4. Enhancement of HHG yield

    International Nuclear Information System (INIS)

    Serrat, C.; Biegert, J.

    2011-01-01

    A static electric field periodically distributed in space controls and enhances the yield in high harmonic generation. The method is relatively simple to implement and allows tuning from the extreme-ultraviolet to soft X-ray. The radiation yield is selectively enhanced due to symmetry breaking induced by a static electric field on the interaction between the driving laser and the medium. The enhanced spectral region is tuned by varying the periodicity of the static electric field. Simulations predict an increase of more than two orders of magnitude for harmonics in the water window spectral range.

  5. Computational evaluation of amplitude modulation for enhanced magnetic nanoparticle hyperthermia.

    Science.gov (United States)

    Soetaert, Frederik; Dupré, Luc; Ivkov, Robert; Crevecoeur, Guillaume

    2015-10-01

    Magnetic nanoparticles (MNPs) can interact with alternating magnetic fields (AMFs) to deposit localized energy for hyperthermia treatment of cancer. Hyperthermia is useful in the context of multimodality treatments with radiation or chemotherapy to enhance disease control without increased toxicity. The unique attributes of heat deposition and transfer with MNPs have generated considerable attention and have been the focus of extensive investigations to elucidate mechanisms and optimize performance. Three-dimensional (3D) simulations are often conducted with the finite element method (FEM) using the Pennes' bioheat equation. In the current study, the Pennes' equation was modified to include a thermal damage-dependent perfusion profile to improve model predictions with respect to known physiological responses to tissue heating. A normal distribution of MNPs in a model liver tumor was combined with empirical nanoparticle heating data to calculate tumor temperature distributions and resulting survival fraction of cancer cells. In addition, calculated spatiotemporal temperature changes were compared among magnetic field amplitude modulations of a base 150-kHz sinusoidal waveform, specifically, no modulation, sinusoidal, rectangular, and triangular modulation. Complex relationships were observed between nanoparticle heating and cancer tissue damage when amplitude modulation and damage-related perfusion profiles were varied. These results are tantalizing and motivate further exploration of amplitude modulation as a means to enhance efficiency of and overcome technical challenges associated with magnetic nanoparticle hyperthermia (MNH).

  6. Dentists United to Extinguish Tobacco (DUET): a study protocol for a cluster randomized, controlled trial for enhancing implementation of clinical practice guidelines for treating tobacco dependence in dental care settings.

    Science.gov (United States)

    Ostroff, Jamie S; Li, Yuelin; Shelley, Donna R

    2014-02-21

    Although dental care settings provide an exceptional opportunity to reach smokers and provide brief cessation advice and treatment to reduce oral and other tobacco-related health conditions, dental care providers demonstrate limited adherence to evidence-based guidelines for treatment of tobacco use and dependence. Guided by a multi-level, conceptual framework that emphasizes changes in provider beliefs and organizational characteristics as drivers of improvement in tobacco treatment delivery, the current protocol will use a cluster, randomized design and multiple data sources (patient exit interviews, provider surveys, site observations, chart audits, and semi-structured provider interviews) to study the process of implementing clinical practice guidelines for treating tobacco dependence in 18 public dental care clinics in New York City. The specific aims of this comparative-effectiveness research trial are to: compare the effectiveness of three promising strategies for implementation of tobacco use treatment guidelines-staff training and current best practices (CBP), CBP + provider performance feedback (PF), and CBP + PF + provider reimbursement for delivery of tobacco cessation treatment (pay-for-performance, or P4P); examine potential theory-driven mechanisms hypothesized to explain the comparative effectiveness of three strategies for implementation; and identify baseline organizational factors that influence the implementation of evidence-based tobacco use treatment practices in dental clinics. The primary outcome is change in providers' tobacco treatment practices and the secondary outcomes are cost per quit, use of tobacco cessation treatments, quit attempts, and smoking abstinence. We hypothesize that the value of these promising implementation strategies is additive and that incorporating all three strategies (CBP, PF, and P4P) will be superior to CBP alone and CBP + PF in improving delivery of cessation assistance to smokers. The findings

  7. Music Enhances Learning.

    Science.gov (United States)

    Campabello, Nicolette; De Carlo, Mary Jane; O'Neil, Jean; Vacek, Mary Jill

    An action research project implemented musical strategies to affect and enhance student recall and memory. The target population was three suburban elementary schools near a major midwestern city: (1) a kindergarten classroom contained 32-38 students; (2) a second grade classroom contained 23 students and five Individualized Education Program…

  8. Progressivity Enhanced

    Directory of Open Access Journals (Sweden)

    Marko Hren

    2013-09-01

    Full Text Available Rather than a scientific text, the author contributes a concise memorandum from the originator of the idea who has managed the campaign for the conversion of the military barracks into a creative cluster between 1988 and 2002, when he parted ways with Metelkova due to conflicting views on the center’s future. His views shed light on a distant period of time from a perspective of a participant–observer. The information is abundantly supported by primary sources, also available online. However, some of the presented hypotheses are heavily influenced by his personal experiences of xenophobia, elitism, and predatorial behavior, which were already then discernible on the so-called alternative scene as well – so much so that they obstructed the implementation of progressive programs. The author claims that, in spite of the substantially different reality today, the myths and prejudices concerning Metelkova must be done away with in order to enhance its progressive nature. Above all, the paper calls for an objective view on internal antagonisms, mainly originating in deep class divisions between the users. These make a clear distinction between truly marginal ndividuals and the overambitious beau-bourgeois, as the author labels the large part of users of Metelkova of »his« time. On these grounds, he argues for a robust approach to ban all forms of xenophobia and self-ghettoization.

  9. Simulation and RTDS Hardware Implementation of SHAF for Mitigation of Current Harmonics with p-q and Id-Iq Control Strategies Using PI Controller

    Directory of Open Access Journals (Sweden)

    A. K. Panda

    2011-06-01

    Full Text Available Control strategies for extracting the three-phase reference currents for shunt active power filters are compared, evaluating their performance under different source conditions in MATLAB/Simulink environment and also with Real Time Digital Simulator (RTDS Hardware. When the supply voltages are balanced and sinusoidal, the two control strategies are converging to the same compensation characteristics but when the supply voltages are distorted and/or un-balanced sinusoidal, these control strategies result in different degrees of compensation in harmonics. The p-q control strategy is unable to yield an adequate solution when source voltages are not ideal. Extensive Simulations are carried out with PI controller for both p-q and Id-Iq control strategies for different voltage conditions and adequate results were presented. The 3-ph 4-wire SHAF system is also implemented on RTDS Hardware to further verify its effectiveness. The detailed simulation and RTDS Hardware results are included.

  10. Evaluating safety management system implementation

    International Nuclear Information System (INIS)

    Preuss, M.

    2009-01-01

    Canada is committed to not only maintaining, but also improving upon our record of having one of the safest aviation systems in the world. The development, implementation and maintenance of safety management systems is a significant step towards improving safety performance. Canada is considered a world leader in this area and we are fully engaged in implementation. By integrating risk management systems and business practices, the aviation industry stands to gain better safety performance with less regulatory intervention. These are important steps towards improving safety and enhancing the public's confidence in the safety of Canada's aviation system. (author)

  11. Efficient uptake of blood-borne BK and JC polyomavirus-like particles in endothelial cells of liver sinusoids and renal vasa recta.

    Directory of Open Access Journals (Sweden)

    Jaione Simon-Santamaria

    Full Text Available Liver sinusoidal endothelial cells (LSECs are specialized scavenger cells that mediate high-capacity clearance of soluble waste macromolecules and colloid material, including blood-borne adenovirus. To explore if LSECs function as a sink for other viruses in blood, we studied the fate of virus-like particles (VLPs of two ubiquitous human DNA viruses, BK and JC polyomavirus, in mice. Like complete virions, VLPs specifically bind to receptors and enter cells, but unlike complete virions, they cannot replicate. 125I-labeled VLPs were used to assess blood decay, organ-, and hepatocellular distribution of ligand, and non-labeled VLPs to examine cellular uptake by immunohisto- and -cytochemistry. BK- and JC-VLPs rapidly distributed to liver, with lesser uptake in kidney and spleen. Liver uptake was predominantly in LSECs. Blood half-life (∼1 min, and tissue distribution of JC-VLPs and two JC-VLP-mutants (L55F and S269F that lack sialic acid binding affinity, were similar, indicating involvement of non-sialic acid receptors in cellular uptake. Liver uptake was not mediated by scavenger receptors. In spleen, the VLPs localized to the red pulp marginal zone reticuloendothelium, and in kidney to the endothelial lining of vasa recta segments, and the transitional epithelium of renal pelvis. Most VLP-positive vessels in renal medulla did not express PV-1/Meca 32, suggesting location to the non-fenestrated part of vasa recta. The endothelial cells of these vessels also efficiently endocytosed a scavenger receptor ligand, formaldehyde-denatured albumin, suggesting high endocytic activity compared to other renal endothelia. We conclude that LSECs very effectively cleared a large fraction of blood-borne BK- and JC-VLPs, indicating a central role of these cells in early removal of polyomavirus from the circulation. In addition, we report the novel finding that a subpopulation of endothelial cells in kidney, the main organ of polyomavirus persistence, showed

  12. Defibrotide for Sinusoidal Obstruction Syndrome/Veno-Occlusive Disease Prophylaxis in High-Risk Adult Patients: A Single-Center Experience Study.

    Science.gov (United States)

    Picod, Adrien; Bonnin, Agnès; Battipaglia, Giorgia; Giannotti, Federica; Ruggeri, Annalisa; Brissot, Eolia; Malard, Florent; Médiavilla, Clémence; Belhocine, Ramdane; Vekhoff, Anne; Gueye, Mor Sény; Lapusan, Simona; Adaeva, Rosa; Isnard, Françoise; Legrand, Ollivier; Baylatry, Minh-Tam; Joly, Anne-Christine; Labopin, Myriam; Duléry, Rémy; Mohty, Mohamad

    2018-03-01

    Sinusoidal obstruction syndrome (SOS), also known as hepatic veno-occlusive disease (VOD), is a serious complication after hematopoietic stem cell transplantation (HSCT). SOS/VOD usually occurs within 3 weeks of HSCT, but the 2016 European Society for Blood and Marrow Transplantation diagnosis criteria have been revised to include late forms. Prophylactic use of defibrotide is recommended in the pediatric setting, but its value remains uncertain in the adult population. We report here a single-center series of 63 adult patients considered at high risk for SOS/VOD who received defibrotide prophylaxis in combination with ursodeoxycholic acid between May 2012 and August 2016. The median duration of defibrotide therapy was 23 days. Bleeding occurred in 14 patients (21.5%). Defibrotide prophylaxis was discontinued in 7 patients (10.8%): 4 cases (6.3%) due to bleeding and 3 cases (4.6%) because of the need for antithrombotic therapy. Overall, SOS/VOD occurred in 4 cases (6.3%) within 21 days after HSCT (days 13 and 14) in 2 cases and late-onset SOS/VOD (days 57 and 58) in the other 2 cases. SOS/VOD was moderate in 1 case, very severe in 3 cases, with 2 deaths related to SOS/VOD. Cumulative incidence of grades II to IV acute graft-versus-host disease and transplant-associated thrombotic microangiopathy were 22.2% and 3.2%, respectively. With a median follow-up of 31 months (range, 10.7 to 60.3), the rates of 2-year overall survival, progression-free survival, incidence of relapse, and nonrelapse mortality were 56.5%, 49%, 28.7%, and 22.3%, respectively. In our experience defibrotide prophylaxis is associated with a low incidence of SOS/VOD after allogeneic HSCT in a high-risk adult population with an acceptable safety profile. Copyright © 2018 The American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.

  13. E-Learning Implementation Issues and Strategies to Address Low Participation Using an Enhanced Model of Acceptance of Web 2.0 Technologies: A Case Study of a Scottish University

    Science.gov (United States)

    Echeng, Razep; Usoro, Abel

    2017-01-01

    Inquiry learning provides the opportunity to develop an improved understanding of concepts being taught to students. It is a useful way of learning which enhances interest and motivation by providing the opportunity to access and manipulate information in a tactical and strategic ways. Web 2.0 technology platforms serve as medium for inquiry…

  14. Implementation of project based learning on the Prakerin subject of vocational high school students of the building engineering to enhance employment skill readiness of graduates in the construction services field

    Science.gov (United States)

    Sugandi, Machmud

    2017-09-01

    Implementation of the Prakerin subject in the field of Building Engineering study program in vocational high school (VHS) are facing many issues associated to non-compliance unit of work in the industry and the expected competencies in learning at school. Project Based Learning (PBL) is an appropriate model learning used for Prakerin subject to increase student competence as the extension of the Prakerin implementation in the construction industry services. Assignments based on the selected project during their practical industry work were given to be completed by student. VHS students in particular field of Building Engineering study program who has been completed Prakerin subject will have a better job readiness, and therefore they will have an understanding on the knowledge, skills, and attitudes and good vision on the construction project in accordance with their experience during Prakerin work in the industry.

  15. Cognitive Processing Therapy for Spanish-speaking Latinos: A Formative Study of a Model-Driven Cultural Adaptation of the Manual to Enhance Implementation in a Usual Care Setting.

    Science.gov (United States)

    Valentine, Sarah E; Borba, Christina P C; Dixon, Louise; Vaewsorn, Adin S; Guajardo, Julia Gallegos; Resick, Patricia A; Wiltsey Stirman, Shannon; Marques, Luana

    2017-03-01

    As part of a larger implementation trial for cognitive processing therapy (CPT) for posttraumatic stress disorder (PTSD) in a community health center, we used formative evaluation to assess relations between iterative cultural adaption (for Spanish-speaking clients) and implementation outcomes (appropriateness and acceptability) for CPT. Qualitative data for the current study were gathered through multiple sources (providers: N = 6; clients: N = 22), including CPT therapy sessions, provider fieldnotes, weekly consultation team meetings, and researcher fieldnotes. Findings from conventional and directed content analysis of the data informed refinements to the CPT manual. Data-driven refinements included adaptations related to cultural context (i.e., language, regional variation in wording), urban context (e.g., crime/violence), and literacy level. Qualitative findings suggest improved appropriateness and acceptability of CPT for Spanish-speaking clients. Our study reinforces the need for dual application of cultural adaptation and implementation science to address the PTSD treatment needs of Spanish-speaking clients. © 2016 Wiley Periodicals, Inc.

  16. Enhancing quantum effects via periodic modulations in optomechanical systems

    Science.gov (United States)

    Farace, Alessandro; Giovannetti, Vittorio

    2012-07-01

    Parametrically modulated optomechanical systems have been recently proposed as a simple and efficient setting for the quantum control of a micromechanical oscillator: relevant possibilities include the generation of squeezing in the oscillator position (or momentum) and the enhancement of entanglement between mechanical and radiation modes. In this paper we further investigate this modulation regime, considering an optomechanical system with one or more parameters being modulated over time. We first apply a sinusoidal modulation of the mechanical frequency and characterize the optimal regime in which the visibility of purely quantum effects is maximal. We then introduce a second modulation on the input laser intensity and analyze the interplay between the two. We find that an interference pattern shows up, so that different choices of the relative phase between the two modulations can either enhance or cancel the desired quantum effects, opening new possibilities for optimal quantum control strategies.

  17. A Low Power Application-Specific Integrated Circuit (ASIC) Implementation of Wavelet Transform/Inverse Transform

    National Research Council Canada - National Science Library

    Harvala, Daniel

    2001-01-01

    .... The ASIC is based on an existing four-chip FPGA implementation. Implementing the design using a dedicated ASIC enhances the speed, decreases chip count to a single die, and uses significantly less power compared to the FPGA implementation...

  18. The phosphoinositide 3-kinase/Akt-signal pathway mediates proliferation and secretory function of hepatic sinusoidal endothelial cells in rats after partial hepatectomy

    International Nuclear Information System (INIS)

    Chen Ping; Zhang Lin; Ding Jiming; Zhu Jin; Li Ying; Duan Shigang; Yan Hongtao; Huan Yongwei; Dong Jiahong

    2006-01-01

    Objective: To investigate the role of AKT signaling pathway in hepatic sinusoidal endothelial cells (SECs) early after partial hepatectomy in rats and the regulatory mechanisms involved. Methods: The animal model of 70% hepatectomy was made. Hepatic SECs were isolated and cultured according to Braet et al.'s method with some modifications. The cultured hepatic SECs were divided into two groups: 70% partial hepatectomy groups and LY294002 group (LY). We observed the expressions of AKT and NF-κB in cultured hepatic SECs by Western blot, measured the levels of NO, NOs, IL-6, and HGF in the supernatants of hepatic SEC cultures and [ 3 H]thymidine incorporation, and analyzed cell cycle of cultured hepatic SECs by flow cytometer. The relationship of the Akt pathway with secretions and proliferation of hepatic SECs after partial hepatectomy was probed. Results: The levels of Akt protein expression increased significantly after partial hepatectomy in OG group and with a peak at 24 h post operation. Meanwhile, there was a markedly increase in phosphorylated Akt protein during 2-72 h after operation. But the expression and activity of Akt protein did not change significantly after partial hepatectomy in the LY group. So, partial hepatectomy can marked induce Akt expression and result in rapid and marked phosphorylation of Akt from 2 to 72 h thereafter. The changes of NF-κB expression in cultured hepatic SECs were similar to those of Akt expression after operation. The concentrations of HGF and IL-6 in the supernatants of cultured hepatic SECs were relatively low in the LY group, and were markedly increased after partial hepatectomy, with a peak at 24 h in the OG group. There were significant differences between the OG and LY groups at 6 and 24 h (P < 0.05). Both NO and NOS secretion was increased in the OG group compared to the LY group within 24 h after partial hepatectomy. But the secretion of NO and NOS was increased more markedly in the LY group than that in the OG

  19. Pre-exposure to moving form enhances static form sensitivity.

    Directory of Open Access Journals (Sweden)

    Thomas S A Wallis

    Full Text Available BACKGROUND: Motion-defined form can seem to persist briefly after motion ceases, before seeming to gradually disappear into the background. Here we investigate if this subjective persistence reflects a signal capable of improving objective measures of sensitivity to static form. METHODOLOGY/PRINCIPAL FINDINGS: We presented a sinusoidal modulation of luminance, masked by a background noise pattern. The sinusoidal luminance modulation was usually subjectively invisible when static, but visible when moving. We found that drifting then stopping the waveform resulted in a transient subjective persistence of the waveform in the static display. Observers' objective sensitivity to the position of the static waveform was also improved after viewing moving waveforms, compared to viewing static waveforms for a matched duration. This facilitation did not occur simply because movement provided more perspectives of the waveform, since performance following pre-exposure to scrambled animations did not match that following pre-exposure to smooth motion. Observers did not simply remember waveform positions at motion offset, since removing the waveform before testing reduced performance. CONCLUSIONS/SIGNIFICANCE: Motion processing therefore interacts with subsequent static visual inputs in a way that can improve performance in objective sensitivity measures. We suggest that the brief subjective persistence of motion-defined forms that can occur after motion offsets is a consequence of the decay of a static form signal that has been transiently enhanced by motion processing.

  20. Towards guideline implementation for integrated local health policies : Evaluation of an experimental implementation strategy in regional health services

    NARCIS (Netherlands)

    Kuunders, T.J.M.; Cloin, J.C.M.; van Bon, M.J.H.; Paulussen, T.G.W.M.; van Oers, J.A.M.; van de Goor, L.A.M.

    2017-01-01

    To enhance implementation of a Guideline for integrated local health policy, a draft implementation strategy (DIS) was developed. It was hypothesized that the DIS would be feasible and effective to enhance the use of a Guideline for integrated local health policy. To examine its feasibility and

  1. Implementing a Capital Plan.

    Science.gov (United States)

    Daigneau, William A.

    2003-01-01

    Addresses four questions regarding implementation of a long-term capital plan to manage a college's facilities portfolio: When should the projects be implemented? How should the capital improvements be implemented? What will it actually cost in terms of project costs as well as operating costs? Who will implement the plan? (EV)

  2. Novel medical image enhancement algorithms

    Science.gov (United States)

    Agaian, Sos; McClendon, Stephen A.

    2010-01-01

    In this paper, we present two novel medical image enhancement algorithms. The first, a global image enhancement algorithm, utilizes an alpha-trimmed mean filter as its backbone to sharpen images. The second algorithm uses a cascaded unsharp masking technique to separate the high frequency components of an image in order for them to be enhanced using a modified adaptive contrast enhancement algorithm. Experimental results from enhancing electron microscopy, radiological, CT scan and MRI scan images, using the MATLAB environment, are then compared to the original images as well as other enhancement methods, such as histogram equalization and two forms of adaptive contrast enhancement. An image processing scheme for electron microscopy images of Purkinje cells will also be implemented and utilized as a comparison tool to evaluate the performance of our algorithm.

  3. Multispectral histogram normalization contrast enhancement

    Science.gov (United States)

    Soha, J. M.; Schwartz, A. A.

    1979-01-01

    A multispectral histogram normalization or decorrelation enhancement which achieves effective color composites by removing interband correlation is described. The enhancement procedure employs either linear or nonlinear transformations to equalize principal component variances. An additional rotation to any set of orthogonal coordinates is thus possible, while full histogram utilization is maintained by avoiding the reintroduction of correlation. For the three-dimensional case, the enhancement procedure may be implemented with a lookup table. An application of the enhancement to Landsat multispectral scanning imagery is presented.

  4. THE IMPLEMENTATION OF CORPORATE PARTNERSHIP PROGRAM WITH SMALL AND MEDIUM ENTERPRISES TO ENHANCE A BUSINESS GROWTH: A STUDY ON THE PARTNERSHIP OF PT. CHAROEN POKPHAND INDONESIA THROUGH PT. SINAR SARANA SENTOSA WITH BROILER CHICKEN BREEDERS IN BLITAR REGENCY

    Directory of Open Access Journals (Sweden)

    Haryanto D.T.

    2017-11-01

    Full Text Available The development of business world today has undergone much progress. Various types of businesses have started to pop up. Speaking of livestock, the livestock sector is an integral part of agricultural sector development prioritized to meet the needs of food and nutrition. The development of livestock sector is part of the overall development which aims to provide food in the form of meat, milk, and eggs which have high nutritional value as well as increasing the farmer's or breeder’s income and expand the employment opportunity. The chickenbroiler is a very effective chicken to produce meat. In general, the main weaknesses in this business lie in the relatively small capital, lack of knowledge on maintaining the management capability, and relatively high price of feed. Another problem that occurs in this business is the field of marketing. One of the best ways that can be recommended in the development of broiler chicken agribusiness is the implementation of vertical coordination system with the partnership pattern. The problem discussed by the author in this study is about the partnership concept application between PT. Charoen Pokphand Indonesia through its subsidiary of PT. Sinar Sarana Sentosa and Small and Medium Enterprises (SMEs of broiler chicken breeders in improving the business growth in Blitar. This study is conditional and can be developed after the researcher conducted the research directly. This aims to analyze the problems about the application of partnerships and factors that support and inhibit the partnership, thus, it is possible that the theory of broiler chicken breeders partnership is developed. This research uses descriptive qualitative approach. In the research results, companies and breeders also need each other. It means that the company needs good breeding results. Breeders as the plasma need guidance to maximize the results. The majority of plasma breeders that participate in the partnership program with PT. Sinar

  5. Cost reducing code implementation strategies

    International Nuclear Information System (INIS)

    Kurtz, Randall L.; Griswold, Michael E.; Jones, Gary C.; Daley, Thomas J.

    1995-01-01

    Sargent and Lundy's Code consulting experience reveals a wide variety of approaches toward implementing the requirements of various nuclear Codes Standards. This paper will describe various Code implementation strategies which assure that Code requirements are fully met in a practical and cost-effective manner. Applications to be discussed includes the following: new construction; repair, replacement and modifications; assessments and life extensions. Lessons learned and illustrative examples will be included. Preferred strategies and specific recommendations will also be addressed. Sargent and Lundy appreciates the opportunity provided by the Korea Atomic Industrial Forum and Korean Nuclear Society to share our ideas and enhance global cooperation through the exchange of information and views on relevant topics

  6. Implementation of the Enhanced Moderated Online Social Therapy (MOST+) Model Within a National Youth E-Mental Health Service (eheadspace): Protocol for a Single Group Pilot Study for Help-Seeking Young People.

    Science.gov (United States)

    Rice, Simon; Gleeson, John; Leicester, Steven; Bendall, Sarah; D'Alfonso, Simon; Gilbertson, Tamsyn; Killackey, Eoin; Parker, Alexandra; Lederman, Reeva; Wadley, Greg; Santesteban-Echarri, Olga; Pryor, Ingrid; Mawren, Daveena; Ratheesh, Aswin; Alvarez-Jimenez, Mario

    2018-02-22

    There is a substantial need for youth electronic mental health (e-mental health) services. In addressing this need, our team has developed a novel moderated online social therapy intervention called enhanced moderated online social therapy (MOST+). MOST+ integrates real-time, clinician-delivered Web chat counseling, interactive user-directed online therapy, expert and peer moderation, and private and secure peer-to-peer social networking. MOST+ has been designed to give young people immediate, 24-hour access to anonymous, evidence-based, and short-term mental health care. The primary aims of this pilot study were to determine the feasibility, acceptability, and safety of the intervention. Secondary aims were to assess prepost changes in key psychosocial outcomes and collect qualitative data for future intervention refinement. MOST+ will be embedded within eheadspace, an Australian youth e-mental health service, and will be evaluated via an uncontrolled single-group study. Approximately 250 help-seeking young people (16-25 years) will be progressively recruited to the intervention from the eheadspace home page over the first 4 weeks of an 8-week intervention period. All participants will have access to evidence-based therapeutic content and integrated Web chat counseling. Additional access to moderated peer-to-peer social networking will be granted to individuals for whom it is deemed safe and appropriate, through a three-tiered screening process. Participants will be enrolled in the MOST+ intervention for 1 week, with the option to renew their enrollment across the duration of the pilot. Participants will complete a survey at enrollment to assess psychological well-being and other mental health outcomes. Additional assessment will occur following account deactivation (ie, after participant has opted not to renew their enrollment, or at trial conclusion) and will include an online survey and telephone interview assessing psychological well-being and experience of

  7. Tip enhancement

    CERN Document Server

    Kawata, Satoshi

    2007-01-01

    This book discusses the recent advances in the area of near-field Raman scattering, mainly focusing on tip-enhanced and surface-enhanced Raman scattering. Some of the key features covered here are the optical structuring and manipulations, single molecule sensitivity, analysis of single-walled carbon nanotubes, and analytic applications in chemistry, biology and material sciences. This book also discusses the plasmonic materials for better enhancement, and optical antennas. Further, near-field microscopy based on second harmonic generation is also discussed. Chapters have been written by some of the leading scientists in this field, who present some of their recent work in this field.·Near-field Raman scattering·Tip-enhanced Raman spectroscopy·Surface-enhanced Raman spectroscopy·Nano-photonics·Nanoanalysis of Physical, chemical and biological materials beyond the diffraction limits·Single molecule detection

  8. Implementation guidelines for seismic PSA

    International Nuclear Information System (INIS)

    Coman, Ovidiu; Samaddar, Sujit; Hibino, Kenta; )

    2014-01-01

    The presentation was devoted to development of guidelines for implementation of a seismic PSA. If successful, these guidelines can close an important gap. ASME/ANS PRA standards and the related IAEA Safety Guide (IAEA NS-G-2.13) describe capability requirements for seismic PSA in order to support risk-informed applications. However, practical guidance on how to meet these requirements is limited. Such guidelines could significantly contribute to improving risk-informed safety demonstration, safety management and decision making. Extensions of this effort to further PSA areas, particularly to PSA for other external hazards, can enhance risk-informed applications

  9. TECHNOLOGICAL IMPLEMENTATION PLAN

    DEFF Research Database (Denmark)

    Bellini, Anna

    2004-01-01

    This document has the purpose to describe the technological implementation plan in the IDEAL project.......This document has the purpose to describe the technological implementation plan in the IDEAL project....

  10. Technology Implementation Plan

    DEFF Research Database (Denmark)

    Jensen, Karsten Ingerslev; Schultz, Jørgen Munthe

    The Technology Implementation Plan (TIP) describes the main project results and the intended future use. The TIP is confidential.......The Technology Implementation Plan (TIP) describes the main project results and the intended future use. The TIP is confidential....

  11. Implementing Student Information Systems

    Science.gov (United States)

    Sullivan, Laurie; Porter, Rebecca

    2006-01-01

    Implementing an enterprise resource planning system is a complex undertaking. Careful planning, management, communication, and staffing can make the difference between a successful and unsuccessful implementation. (Contains 3 tables.)

  12. Ecodesign Implementation and LCA

    DEFF Research Database (Denmark)

    McAloone, Tim C.; Pigosso, Daniela Cristina Antelmi

    2018-01-01

    implementation into manufacturing companies. Existing methods and tools for ecodesign implementation will be described, focusing on a multifaceted approach to environmental improvement through product development. Additionally, the use of LCA in an ecodesign implementation context will be further described...... in terms of the challenges and opportunities, together with the discussion of a selection of simplified LCA tools. Finally, a seven-step approach for ecodesign implementation which has been applied by several companies will be described....

  13. Implementing Replacement Cost Accounting

    Science.gov (United States)

    1976-12-01

    cost accounting Clickener, John Ross Monterey, California. Naval Postgraduate School http://hdl.handle.net/10945/17810 Downloaded from NPS Archive...Calhoun IMPLEMENTING REPLACEMENT COST ACCOUNTING John Ross CHckener NAVAL POSTGRADUATE SCHOOL Monterey, California THESIS IMPLEMENTING REPLACEMENT COST ...Implementing Replacement Cost Accounting 7. AUTHORS John Ross Clickener READ INSTRUCTIONS BEFORE COMPLETING FORM 3. RECIPIENT’S CATALOG NUMBER 9. TYRE OF

  14. Coeur d'Alene Tribe Fish and Wildlife Program Habitat Protection Plan; Implementation of Fisheries Enhancement Opportunities on the Coeur d'Alene Reservation, 1997-2002 Technical Report.

    Energy Technology Data Exchange (ETDEWEB)

    Vitale, Angelo; Roberts, Frank; Peters, Ronald

    2002-06-01

    , including the Coeur d'Alene Indian Reservation (Coeur d'Alene Tribe 1998). Implicit in this statement is a commitment to provide native subsistence resources in the present and near future as well as the long-term by employing all the mitigation and conservation measures available to them. The development of this Habitat Protection Plan is intended to provide additional planning level guidance as the implementation of conservation measures moves forward. The purpose of this plan is to develop a systematic approach to habitat restoration that will ultimately lead to self-perpetuating, harvestable populations of native fish, wildlife and botanical species. Specifically, it is our intention to apply the principles and analyses presented in this plan to prioritize future restoration efforts that receive funding under the Northwest Power Planning Council's Resident Fish and Wildlife Mitigation Programs. Using an ecosystem restoration approach based on landscape ecology concepts (Primack 1993), the basic premise of the plan is to (1) protect functioning habitat conditions and (2) restore degraded habitat conditions. This plan focuses on habitat conditions at the watershed scale (macrohabitat) rather than on the needs of single species and/or species guilds. By focusing restoration efforts at a macrohabitat level, restoration efforts target all native species inhabiting that area. This approach marks a paradigm shift that emphasizes ecological based restoration rather than species-specific restoration. Traditionally, fish managers and wildlife managers have approached restoration independently, often dedicating resources to a single species by focusing on specific habitat types on a small spatial scale (microhabitat) (Robinson and Bolen 1989, Marcot et al. 2002). This management technique has done little to curb declines despite large budgets (Pianka 1994). Restoration on a landscape level has shown promising results (Holling 1992) and many riparian and wetland

  15. Enhancing photon squeezing one leviton at a time

    Science.gov (United States)

    Ferraro, D.; Ronetti, F.; Rech, J.; Jonckheere, T.; Sassetti, M.; Martin, T.

    2018-04-01

    A mesoscopic device in the simple tunnel junction or quantum point contact geometry emits microwaves with remarkable quantum properties, when subjected to a sinusoidal drive in the GHz range. In particular, single and two-photon squeezing as well as entanglement in the frequency domain have been reported. By revising the photoassisted noise analysis developed in the framework of electron quantum optics, we present a detailed comparison between the cosine drive case and other experimentally relevant periodic voltages such as rectangular and Lorentzian pulses. We show that the latter drive is the best candidate in order to enhance quantum features and purity of the outgoing single and two-photon states, a noteworthy result in a quantum information perspective.

  16. Implementering & Performative Potentialer

    DEFF Research Database (Denmark)

    Damkjer, Annemarie

    organizational boundaries. Furthermore, the analysis reflect how specific modes of ordering in the local process of implementation perform and displace the technology of performance management. The study provides an alternative view of the performative potentials in implementation processes and specifically...... challenge the traditional models of implementation. It is suggested, that we view implementation practices as performative in relation to the co-configuration of technology and organizational practices and that both the co-configurative perspective and the materiality of implementation practices is included......This thesis investigates how technology is constituted as an object of implementation. Using the theoretical lens of actor-network theory the thesis investigates how the technology of performance management becomes a matter of implementation in the Danish Defence and how the technology...

  17. Evolution of the dicalcium phosphate-dihydrate (DCPD coating created by large amplitude sinusoidal voltammetry (LASV on corrosion resistance of the ZW3 magnesium alloy in chloride containing environment

    Directory of Open Access Journals (Sweden)

    Kajánek D.

    2018-02-01

    Full Text Available The contribution is focused on the preparation of coating based on the dicalcium phosphate-dihydrate (DCPD on the surface of ZW3 magnesium alloy. For the preparation of the coating a cathodic electrodeposition technique called Large Amplitude Sinusoidal Voltammetry (LASV was used. The DCPD layer was prepared at the temperature of 22 ± 2 °C in electrolyte composed of 0.1M Ca(NO3.4H2O, 0.06 M NH4H2PO4 and H2O2. Electrochemical characteristics were evaluated by electrochemical impedance spectroscopy (EIS in 0.1M NaCl solution. The obtained data in form of Nyquist plots were analysed by the equivalent circuit method. It is clear from the measured values of polarization resistance Rp that dicalcium phosphate-dihydrate (DCPD layer prepared by LASV electro-deposition technique improved corrosion resistance of ZW3 alloy in the chosen environment.

  18. Biocatalyst Enhancement

    Science.gov (United States)

    The increasing availability of enzyme collections has assisted attempts by pharmaceutical producers to adopt green chemistry approaches to manufacturing. A joint effort between an enzyme producer and a pharmaceutical manufacturer has been enhanced over the past three years by ena...

  19. Implementing a trustworthy cost-accounting model.

    Science.gov (United States)

    Spence, Jay; Seargeant, Dan

    2015-03-01

    Hospitals and health systems can develop an effective cost-accounting model and maximize the effectiveness of their cost-accounting teams by focusing on six key areas: Implementing an enhanced data model. Reconciling data efficiently. Accommodating multiple cost-modeling techniques. Improving transparency of cost allocations. Securing department manager participation. Providing essential education and training to staff members and stakeholders.

  20. Institutional aspects of NAMA development and implementation

    DEFF Research Database (Denmark)

    Hinostroza, Miriam L.; Sharma, Sudhir; Karavai, Maryna

    This publication analyses how developing countries may arrange their institutional and organizational structures or enhance the existing ones in order to deal with these new developments under the international climate change mitigation regime. Focus is on how to ensure the implementation of NAMAs...