WorldWideScience

Sample records for impact profile sip

  1. The Impact of Dopant Segregation on the Maximum Carrier Density in Si:P Multilayers.

    Science.gov (United States)

    Keizer, Joris G; McKibbin, Sarah R; Simmons, Michelle Y

    2015-07-28

    Abrupt dopant profiles and low resistivity are highly sought after qualities in the silicon microelectronics industry and, more recently, in the development of an all epitaxial Si:P based quantum computer. If we increase the active carrier density in silicon to the point where the material becomes superconducting, while maintaining a low thermal budget, it will be possible to fabricate nanoscale superconducting devices using the highly successful technique of depassivation lithography. In this work, we investigate the dopant profile and activation in multiple high density Si:P δ-layers fabricated by stacking individual layers with intervening silicon growth. We determine that dopant activation is ultimately limited by the formation of P-P dimers due to the segregation of dopants between multilayers. By increasing the encapsulation thickness between subsequent layers, thereby minimizing the formation of these deactivating defects, we are able to achieve an active carrier density of ns = 4.5 ×10(14) cm(-2) for a triple layer. The results of electrical characterization are combined with those of secondary ion mass spectroscopy to construct a model that accurately describes the impact of P segregation on the final active carrier density in Si:P multilayers. Our model predicts that a 3D active carrier density of 8.5 × 10(20) cm(-3) (1.7 atom %) can be achieved.

  2. Impact of 50% Synthesized Iso-Paraffins (SIP) on F-76 Fuel Coalescence

    Science.gov (United States)

    2013-12-16

    petroleum JP-5 and Synthesized Iso-Paraffins (SIP). SIP fuels are made from direct fermentation of sugar into olefinic hydrocarbons. The olefinic...manufactured scaled down filter/coalescer and separator to simulate the performance of a full-scale filter separator system. This test is designed to predict...5 and Synthesized Iso-Paraffins (SIP). SIP fuels are made from direct fermentation of sugar into olefinic hydrocarbons. The olefinic hydrocarbons

  3. Stress-induced premature senescence (SIPS)--influence of SIPS on radiotherapy.

    Science.gov (United States)

    Suzuki, Masatoshi; Boothman, David A

    2008-03-01

    Replicative senescence is a fundamental feature in normal human diploid cells and results from dysfunctional telomeres at the Hayflick cell division limit. Ionizing radiation (IR) prematurely induces the same phenotypes as replicative senescence prior to the Hayflick limit. This process is known as stress-induced premature senescence (SIPS). Since the cell cycle is irreversibly arrested in SIPS-induced cells, even if they are stimulated by various growth factors, it is thought that SIPS is a form of cell death, irreversibly eliminating replicating cells. IR-induced-focus formation of DNA repair proteins, a marker of DNA damage, is detected in SIPS as well as replicative senescent cells. Furthermore, both processes persistently induce cell cycle checkpoint mechanisms, indicating DNA damage created by ionizing radiation induces SIPS in normal cells, possibly by the same mechanisms as those occurring in replicative senescence. Interestingly, IR induces SIPS not only in normal cells, but also in tumor cells. Due to the expression of telomerase in tumor cells, telomere-dependent replicative senescence does not occur. However, SIPS is induced under certain conditions after IR exposure. Thus, cell death triggered by IR can be attributed to apoptosis or SIPS in tumor cells. However, metabolic function remains intact in SIPS-induced cancer cells, and recent studies show that senescence eliminate cells undergoing SIPS secrete various kinds of factors outside the cell, changing the microenvironment. Evidence using co-culture systems containing normal senescent stromal cells and epithelial tumor cells show that factors secreted from senescent stroma cells promote the growth of tumor epithelial cells both in vitro and in vivo. Thus, regulation of factors secreted from SIPS-induced stromal cells, as well as tumor cells, may affect radiotherapy.

  4. Stress-induced premature senescence (SIPS). Influence of SIPS on radiotherapy

    International Nuclear Information System (INIS)

    Suzuki, Masatoshi; Boothman, D.A.

    2008-01-01

    Replicative senescence is a fundamental feature in normal human diploid cells and results from dysfunctional telomeres at the Hayflick cell division limit. Ionizing radiation (IR) prematurely induces the same phenotypes as replicative senescence prior to the Hayflick limit. This process is known as stress-induced premature senescence (SIPS). Since the cell cycle is irreversibly arrested in SIPS-induced cells, even if they are stimulated by various growth factors, it is thought that SIPS is a form of cell death, irreversibly eliminating replicating cells. IR-induced-focus formation of DNA repair proteins, a marker of DNA damage, is detected in SIPS as well as replicative senescent cells. Furthermore, both processes persistently induce cell cycle checkpoint mechanisms, indicating DNA damage created by ionizing radiation induces SIPS in normal cells, possibly by the same mechanisms as those occurring in replicative senescence. Interestingly, IR induces SIPS not only in normal cells, but also in tumor cells. Due to the expression of telomerase in tumor cells, telomere-dependent replicative senescence does not occur. However, SIPS is induced under certain conditions after IR exposure. Thus, cell death triggered by IR can be attributed to apoptosis or SIPS in tumor cells. However, metabolic function remains intact in SIPS-induced cancer cells, and recent studies show that senescence eliminate cells undergoing SIPS secrete various kinds of factors outside the cell, changing the microenvironment. Evidence using co-culture systems containing normal senescent stromal cells and epithelial tumor cells show that factors secreted from senescent stroma cells promote the growth of tumor epithelial cells both in vitro and in vivo. Thus, regulation of factors secreted from SIPS-induced stromal cells, as well as tumor cells, may affect radiotherapy. (author)

  5. The Sickness Impact Profile: Potential Use of a Health Status Instrument for Physician Training

    Science.gov (United States)

    Martin, Diane P.; And Others

    1976-01-01

    The Sickness Impact Profile (SIP) is designed to measure health status in terms of sickness-related changes in behavior. Its content incorporates the perspectives of clinicians, patients, and the apparently healthy, and consists of 235 items. Its reliability and validity were supported in a study with both experienced physicians and residents.…

  6. The Sickness Impact Profile as a measure of the health status of noncognitively impaired nursing home residents.

    Science.gov (United States)

    Rothman, M L; Hedrick, S; Inui, T

    1989-03-01

    The Sickness Impact Profile (SIP) is a multidimensional, behaviorally based measure of the health status that has been successfully used in a wide range of applications. The characteristics of this measure have not been assessed with nursing home residents. The purpose of this study was to assess the feasibility, reliability (internal consistency), validity, and comprehensiveness of the SIP as a measure of the health status of a selected group of nursing home residents. One hundred sixty-eight veterans residing in community and VA nursing homes responded to a questionnaire consisting of the SIP, Index of Activities of Daily Living, Barthel Index, Life Satisfaction Index Z, and the Philadelphia Geriatric Center Morale Scale. In general, the respondents correctly interpreted instructions; reliability and validity were supported; and the SIP was found to provide a comprehensive assessment of physical function. Adding a measure of psychologic well-being to a study protocol involving this population may, however, provide additional useful information regarding this construct.

  7. 76 FR 28437 - Disease, Disability, and Injury Prevention and Control Special Interest Projects (SIPs): Initial...

    Science.gov (United States)

    2011-05-17

    ... Preventive Services for Older Adults SIP11-045, and Measuring Impact of Multi-Component Interventions to Prevent Older Adult Falls and Assessing Sustainability and Scalability, SIP 11-046, Panel D,'' initial... SIP11-045, and Measuring Impact of Multi- Component Interventions to Prevent Older Adult Falls and...

  8. Impact of 50% Synthesized Iso-Paraffins (SIP) on Middle Distillate Fuel Filtration and Coalescence

    Science.gov (United States)

    2014-10-30

    Paraffins DEFINITIONS Coalescence - the ability to shed water Conventional Material Source - crude oil , natural gas liquid condensates...Impact of 50% Synthesized Iso-Paraffins (SIP) on Middle Distillate Fuel Filtration and Coalescence NF&LCFT REPORT 441/15-003 30 October 2014...heavy oil , shale oil , and oil sands Effluent - stream leaving a system Influent - stream entering a system Turnover - time required to flow the

  9. Measuring SIP proxy server performance

    CERN Document Server

    Subramanian, Sureshkumar V

    2013-01-01

    Internet Protocol (IP) telephony is an alternative to the traditional Public Switched Telephone Networks (PSTN), and the Session Initiation Protocol (SIP) is quickly becoming a popular signaling protocol for VoIP-based applications. SIP is a peer-to-peer multimedia signaling protocol standardized by the Internet Engineering Task Force (IETF), and it plays a vital role in providing IP telephony services through its use of the SIP Proxy Server (SPS), a software application that provides call routing services by parsing and forwarding all the incoming SIP packets in an IP telephony network.SIP Pr

  10. SIP end to end performance metrics

    OpenAIRE

    Vozňák, Miroslav; Rozhon, Jan

    2012-01-01

    The paper deals with a SIP performance testing methodology. The main contribution to the field of performance testing of SIP infrastructure consists in the possibility to perform the standardized stress tests with the developed SIP TesterApp without a deeper knowledge in the area of SIP communication. The developed tool exploits several of open-source applications such as jQuery, Python, JSON and the cornerstone SIP generator SIPp, the result is highly modifiable and the ...

  11. Instant Messaging by SIP

    Science.gov (United States)

    Muhi, Daniel; Dulai, Tibor; Jaskó, Szilárd

    2008-11-01

    SIP is a general-purpose application layer protocol which is able to establish sessions between two or more parties. These sessions are mainly telephone calls and multimedia conferences. However it can be used for other purposes like instant messaging and presence service. SIP has a very important role in mobile communication as more and more communicating applications are going mobile. In this paper we would like to show how SIP can be used for instant messaging purposes.

  12. Lightweight SIP/SDP compression scheme (LSSCS)

    Science.gov (United States)

    Wu, Jian J.; Demetrescu, Cristian

    2001-10-01

    In UMTS new IP based services with tight delay constraints will be deployed over the W-CDMA air interface such as IP multimedia and interactive services. To integrate the wireline and wireless IP services, 3GPP standard forum adopted the Session Initiation Protocol (SIP) as the call control protocol for the UMTS Release 5, which will implement next generation, all IP networks for real-time QoS services. In the current form the SIP protocol is not suitable for wireless transmission due to its large message size which will need either a big radio pipe for transmission or it will take far much longer to transmit than the current GSM Call Control (CC) message sequence. In this paper we present a novel compression algorithm called Lightweight SIP/SDP Compression Scheme (LSSCS), which acts at the SIP application layer and therefore removes the information redundancy before it is sent to the network and transport layer. A binary octet-aligned header is added to the compressed SIP/SDP message before sending it to the network layer. The receiver uses this binary header as well as the pre-cached information to regenerate the original SIP/SDP message. The key features of the LSSCS compression scheme are presented in this paper along with implementation examples. It is shown that this compression algorithm makes SIP transmission efficient over the radio interface without losing the SIP generality and flexibility.

  13. DoS attacks targeting SIP server and improvements of robustness

    OpenAIRE

    Vozňák, Miroslav; Šafařík, Jakub

    2012-01-01

    The paper describes the vulnerability of SIP servers to DoS attacks and methods for server protection. For each attack, this paper describes their impact on a SIP server, evaluation of the threat and the way in which they are executed. Attacks are described in detail, and a security precaution is made to prevent each of them. The proposed solution of the protection is based on a specific topology of an intrusion protection systems components consisting of a combination of...

  14. SIP protocol model for OMNET++

    Directory of Open Access Journals (Sweden)

    Jan Kucerak

    2016-01-01

    Full Text Available The article describes our new SIP protocol implementation for the OMNeT++ simulation framework. OMNeT++ simulation framework provides an extensive support of IP related protocols, nevertheless a working SIP protocol implementation is missing. Real measurements were also done using a SIPp traffic generator and the results are compared to those obtained by our new SIP model. Since this work is a part of bigger project concerned strictly on measuring "first response times" over networks with a faulty transmission links, the actually collected statistics are focused only this way.

  15. Mast-sipping in EPR trademark plants

    International Nuclear Information System (INIS)

    Langenberger, Jan; Schienbein, Marcel; Geier, Roland

    2010-01-01

    For more than 20 years, AREVA applies and develops different sipping techniques to identify fuel assemblies with leaking fuel rods. For the EPR trademark reactors a Mast Sipping System with newest developments will be implemented considering radiation protection and latest standards requirements. The innovative EPR trademark Sipping System differs from previous systems in many ways. One of the main innovations is that all the necessary processes of the Sipping system have been fully digitized. Second, several ALARA design modifications have been implemented to meet the current radiation protection requirements. An additional implementable multilingual assistance program facilitates the handling of the system and helps to prevent incorrect operation. (orig.)

  16. Cooperation of Ukrainian regulatory authorities in the SIP

    Energy Technology Data Exchange (ETDEWEB)

    Kutina, L.; Bachner, D.; Bykov, V.; Erickson, L.; Kondralyev, S.; Redko, V.; Simonov, I.; Vasilchenko, V. [SSTC NRS, Stusa St. 35-37, 03142, Kyiv (Ukraine)

    2003-07-01

    The State Nuclear Regulatory Committee of Ukraine (SNRCU) supported by the State Scientific and Technical Center (SSTC) and the Licensing consultant (LC - RISKAUDIT/SCIENTECH) coordinates the activities of other regulatory authorities (RA) within the Shelter Implementation Plan (SIP) licensing. A protocol on cooperation and differentiation of competence in the SIP has been agreed between SNRCU and other RA (Ecology, Health, Construction, Occupational safety, Fire). The RA intended to carry out their activities such that SIP be implemented in the most efficient way by: - providing the Chernobyl NPP with a possibility to choose optimal variants for Shelter transformation; - minimizing required regulatory steps for SIP; - reviewing SIP documents at the initial stages of development of SIP designs; - providing consultative support by technical support organizations (TSO) on the SIP designs; - relating regulatory decisions on safety issues to the competence of the inspection at the Chernobyl NPP site. Coordination of regulatory activity and cooperation in safety areas are presented.

  17. LOCATION-BASED SERVICES USING SIP

    OpenAIRE

    Abdullah Azfar,; Md. Sakhawat Hossen,; María José Peroza Marval; Razib Hayat Khan

    2010-01-01

    Due to the popularity of Location-Based Services and IP telephony, we decided to review a number of different proposals to implement Location-Based Services over a SIP-based mobile network. The result is an interesting overview about the potential functionalities of Location-Based Services and the capabilities of SIP for implementingthese services.

  18. 75 FR 28626 - Disease, Disability, and Injury Prevention and Control Special Interest Projects (SIPs): SIP 10...

    Science.gov (United States)

    2010-05-21

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and Control Special Interest Projects (SIPs): SIP 10-029, Pilot Study... Act (Pub. L. 92-463), the Centers for Disease Control and Prevention (CDC) announces the...

  19. 75 FR 32190 - Disease, Disability, and Injury Prevention and Control Special Interest Projects (SIPs): SIP 10...

    Science.gov (United States)

    2010-06-07

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and Control Special Interest Projects (SIPs): SIP 10-033, Innovative... with Section 10(a)(2) of the Federal Advisory Committee Act (Pub. L. 92-463), the Centers for Disease...

  20. On TCP-based Session Initiation Protocol (SIP) Server Overload Control

    OpenAIRE

    Shen, Charles; Schulzrinne, Henning

    2010-01-01

    The Session Initiation Protocol (SIP) server overload management has attracted interest since SIP is being widely deployed in the Next Generation Networks (NGN) as a core signaling protocol. Yet all existing SIP overload control work is focused on SIP-over-UDP, despite the fact that TCP is increasingly seen as the more viable choice of SIP transport. This paper answers the following questions: is the existing TCP flow control capable of handling the SIP overload problem? If not, why and how c...

  1. SIP threats detection system

    OpenAIRE

    Vozňák, Miroslav; Řezáč, Filip

    2010-01-01

    The paper deals with detection of threats in IP telephony, the authors developed a penetration testing system that is able to check up the level of protection from security threats in IP telephony. The SIP server is a key komponent of VoIP infrastructure and often becomes the aim of attacks and providers have to ensure the appropriate level of security. We have developed web-based penetration system which is able to check the SIP server if can face to the most common attacks.The d...

  2. Integrating Usage Control with SIP-Based Communications

    Directory of Open Access Journals (Sweden)

    A. Lakas

    2008-11-01

    Full Text Available The Session Initiation Protocol (SIP is a signaling protocol used for establishing and maintaining communication sessions involving two or more participants. SIP was initially designed for voice over IP and multimedia conferencing, and then was extended to support other services such as instant messaging and presence management. Today, SIP is also adopted to be used with 3G wireless networks, thus it becomes an integral protocol for ubiquitous environment. SIP has various methods that support a variety of applications such as subscribing to a service, notification of an event, status update, and location and presence services. However, when it comes to security, the use of wireless and mobile communication technologies and the pervasive nature of this environment introduce higher risks to security than that of the old simple environment. In this paper, we introduce new architecture that implements a new type of access control called usage access control (UCON to control the access to the SIP-based communication at preconnection, during connection, and postconnection. This will enable prescribers of SIP services to control who can identify their locations to approve or disapprove their subsequent connections, and to also set some parameters to determine whether a certain communication can continue or should terminate.

  3. Overload Control in a SIP Signaling Network

    OpenAIRE

    Masataka Ohta

    2007-01-01

    The Internet telephony employs a new type of Internet communication on which a mutual communication is realized by establishing sessions. Session Initiation Protocol (SIP) is used to establish sessions between end-users. For unreliable transmission (UDP), SIP message should be retransmitted when it is lost. The retransmissions increase a load of the SIP signaling network, and sometimes lead to performance degradation when a network is overloaded. The paper proposes an overload control for a S...

  4. Clone of EPA Approved Regulations in the Texas SIP

    Science.gov (United States)

    changed name to EPA Approved Regulations in the Texas SIP, Add links to:Texas Read Me; Texas SIP History;Current/Previous SIP-Approved Regulations; Delete regulations--now in /node/191099, removed tables

  5. TELESCOPE sipping - a proven fuel leak detection system

    International Nuclear Information System (INIS)

    Deleryd, R.; Collin, P.

    1996-01-01

    The advantages of the TELESCOPE sipping method are: For BWRs: clamp-on sipping nozzle, which attaches easily to the grapple of the telescope mast on the refuelling platform, but does not affect its operation; no heavy and large sipping bells have to be operated in the core with risk of damage, entangled hoses or lifting rods/wires; the sipping can also be performed for testing long time storaged fuel in the spent fuel pool. For PWRs: simple attachment of water suction hose or tube to the refuelling platform mast. (orig./DG)

  6. NAT Traversing Solutions for SIP Applications

    Directory of Open Access Journals (Sweden)

    Huang Ya-Lin

    2008-01-01

    Full Text Available Abstract Session Initiation Protocol (SIP has been proposed for multimedia services and wide-area connectivity in smart home environments (SHEs. An important issue for SIP deployment in SHEs is network address translator (NAT traversing. SIP and Real-time Transport Protocol (RTP packets are delivered between an SHE (i.e., private IP network and Internet (i.e., a public IP network through an NAT function of a home gateway, and the NAT translates the IP/transport layer address and port number but leaves the application layer content unchanged. This results in inconsistency between the IP addresses/port numbers in the IP/transport layers and those in the SIP layer. To resolve this issue, we describe six solutions including static route, UPnP, STUN, ICE, ALG, and SBC. Then we compare these solutions in terms of smart home appliance (SHA modification, scope of NATs supported, multilayer NAT traversal, ease of configuration, security issue, and time complexities.

  7. NAT Traversing Solutions for SIP Applications

    Directory of Open Access Journals (Sweden)

    Han-Chieh Chao

    2008-05-01

    Full Text Available Session Initiation Protocol (SIP has been proposed for multimedia services and wide-area connectivity in smart home environments (SHEs. An important issue for SIP deployment in SHEs is network address translator (NAT traversing. SIP and Real-time Transport Protocol (RTP packets are delivered between an SHE (i.e., private IP network and Internet (i.e., a public IP network through an NAT function of a home gateway, and the NAT translates the IP/transport layer address and port number but leaves the application layer content unchanged. This results in inconsistency between the IP addresses/port numbers in the IP/transport layers and those in the SIP layer. To resolve this issue, we describe six solutions including static route, UPnP, STUN, ICE, ALG, and SBC. Then we compare these solutions in terms of smart home appliance (SHA modification, scope of NATs supported, multilayer NAT traversal, ease of configuration, security issue, and time complexities.

  8. Protocol d'inicialització de sessió SIP

    OpenAIRE

    Ibrahem Fernández, Samer

    2006-01-01

    Aquest projecte té com a finalitat estudiar el protocol SIP i desenvolupar una aplicació que l'implementi. Este proyecto tiene como finalidad estudiar el protocolo SIP y desarrollar una aplicación que la implemente The purpose of this project is to study the SIP protocol and develop an application that implements it.

  9. eSIP: A Novel Solution-Based Sectioned Image Property Approach for Microscope Calibration.

    Directory of Open Access Journals (Sweden)

    Malte Butzlaff

    Full Text Available Fluorescence confocal microscopy represents one of the central tools in modern sciences. Correspondingly, a growing amount of research relies on the development of novel microscopic methods. During the last decade numerous microscopic approaches were developed for the investigation of various scientific questions. Thereby, the former qualitative imaging methods became replaced by advanced quantitative methods to gain more and more information from a given sample. However, modern microscope systems being as complex as they are, require very precise and appropriate calibration routines, in particular when quantitative measurements should be compared over longer time scales or between different setups. Multispectral beads with sub-resolution size are often used to describe the point spread function and thus the optical properties of the microscope. More recently, a fluorescent layer was utilized to describe the axial profile for each pixel, which allows a spatially resolved characterization. However, fabrication of a thin fluorescent layer with matching refractive index is technically not solved yet. Therefore, we propose a novel type of calibration concept for sectioned image property (SIP measurements which is based on fluorescent solution and makes the calibration concept available for a broader number of users. Compared to the previous approach, additional information can be obtained by application of this extended SIP chart approach, including penetration depth, detected number of photons, and illumination profile shape. Furthermore, due to the fit of the complete profile, our method is less susceptible to noise. Generally, the extended SIP approach represents a simple and highly reproducible method, allowing setup independent calibration and alignment procedures, which is mandatory for advanced quantitative microscopy.

  10. High Load Diminution by Regulating Timers in SIP Servers

    OpenAIRE

    Montazerolghaem, Ahmadreza; Hosseini-Seno, Seyed-Amin; Yaghmaee, Mohammad Hossein; Budiarto, Rahmat

    2014-01-01

    To start voice, image, instant messaging, and generally multimedia communication, session communication must begin between two participants. SIP (session initiation protocol) that is an application layer control induces management and terminates this kind of sessions. As far as the independence of SIP from transport layer protocols is concerned, SIP messages can be transferred on a variety of transport layer protocols including TCP or UDP. Mechanism of Retransmission that is embedded in SIP c...

  11. Measurements of SIP Signaling over 802.11b Links

    NARCIS (Netherlands)

    Hesselman, C.E.W.; Eertink, Henk; Eertink, E.H.; Widya, I.A.; Huizer, E.

    The Session Initiation Protocol (SIP) is a popular application-level signaling protocol that is used for a wide variety of applications such as session control and mobility handling. In some of these applications, the exchange of SIP messages is time-critical, for instance when SIP is used to handle

  12. {sup 124}I-L19-SIP for immuno-PET imaging of tumour vasculature and guidance of {sup 131}I-L19-SIP radioimmunotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Tijink, Bernard M.; Perk, Lars R.; Budde, Marianne; Stigter-van Walsum, Marijke; Leemans, C.R. [VU University Medical Center, Department of Otolaryngology/Head and Neck Surgery, Amsterdam (Netherlands); Visser, Gerard W.M.; Kloet, Reina W. [VU University Medical Center, Nuclear Medicine and PET Research, Amsterdam (Netherlands); Dinkelborg, Ludger M. [Bayer Schering Pharma AG, Global Drug Discovery, Berlin (Germany); Neri, Dario [Swiss Federal Institute of Technology, Institute of Pharmaceutical Sciences, Zurich (Switzerland); Dongen, Guus A.M.S. van [VU University Medical Center, Department of Otolaryngology/Head and Neck Surgery, Amsterdam (Netherlands); VU University Medical Center, Nuclear Medicine and PET Research, Amsterdam (Netherlands)

    2009-08-15

    The human monoclonal antibody (MAb) fragment L19-SIP is directed against extra domain B (ED-B) of fibronectin, a marker of tumour angiogenesis. A clinical radioimmunotherapy (RIT) trial with {sup 131}I-L19-SIP was recently started. In the present study, after GMP production of {sup 124}I and efficient production of {sup 124}I-L19-SIP, we aimed to demonstrate the suitability of {sup 124}I-L19-SIP immuno-PET for imaging of angiogenesis at early-stage tumour development and as a scouting procedure prior to clinical {sup 131}I-L19-SIP RIT. {sup 124}I was produced in a GMP compliant way via {sup 124}Te(p,n){sup 124}I reaction and using a TERIMO trademark module for radioiodine separation. L19-SIP was radioiodinated by using a modified version of the IODO-GEN method. The biodistribution of coinjected {sup 124}I- and {sup 131}I-L19-SIP was compared in FaDu xenograft-bearing nude mice, while {sup 124}I PET images were obtained from mice with tumours of <50 to {proportional_to}700 mm{sup 3}. {sup 124}I was produced highly pure with an average yield of 15.4 {+-} 0.5 MBq/{mu}Ah, while separation yield was {proportional_to}90% efficient with <0.5% loss of TeO{sub 2}. Overall labelling efficiency, radiochemical purity and immunoreactive fraction were for {sup 124}I-L19-SIP: {proportional_to}80, 99.9 and >90%, respectively. Tumour uptake was 7.3{+-}2.1, 10.8{+-}1.5, 7.8{+-}1.4, 5.3{+-}0.6 and 3.1{+-}0.4%ID/g at 3, 6, 24, 48 and 72 h p.i., resulting in increased tumour to blood ratios ranging from 6.0 at 24 h to 45.9 at 72 h p.i. Fully concordant labelling and biodistribution results were obtained with {sup 124}I- and {sup 131}I-L19-SIP. Immuno-PET with {sup 124}I-L19-SIP using a high-resolution research tomograph PET scanner revealed clear delineation of the tumours as small as 50 mm{sup 3} and no adverse uptake in other organs. {sup 124}I-MAb conjugates for clinical immuno-PET can be efficiently produced. Immuno-PET with {sup 124}I-L19-SIP appeared qualified for sensitive

  13. Two Stage Secure Dynamic Load Balancing Architecture for SIP Server Clusters

    Directory of Open Access Journals (Sweden)

    G. Vennila

    2014-08-01

    Full Text Available Session Initiation Protocol (SIP is a signaling protocol emerged with an aim to enhance the IP network capabilities in terms of complex service provision. SIP server scalability with load balancing has a greater concern due to the dramatic increase in SIP service demand. Load balancing of session method (request/response and security measures optimizes the SIP server to regulate of network traffic in Voice over Internet Protocol (VoIP. Establishing a honeywall prior to the load balancer significantly reduces SIP traffic and drops inbound malicious load. In this paper, we propose Active Least Call in SIP Server (ALC_Server algorithm fulfills objectives like congestion avoidance, improved response times, throughput, resource utilization, reducing server faults, scalability and protection of SIP call from DoS attacks. From the test bed, the proposed two-tier architecture demonstrates that the ALC_Server method dynamically controls the overload and provides robust security, uniform load distribution for SIP servers.

  14. CacyBP/SIP promotes the proliferation of colon cancer cells.

    Directory of Open Access Journals (Sweden)

    Huihong Zhai

    Full Text Available CacyBP/SIP is a component of the ubiquitin pathway and is overexpressed in several transformed tumor tissues, including colon cancer, which is one of the most common cancers worldwide. It is unknown whether CacyBP/SIP promotes the proliferation of colon cancer cells. This study examined the expression level, subcellular localization, and binding activity of CacyBP/SIP in human colon cancer cells in the presence and absence of the hormone gastrin. We found that CacyBP/SIP was expressed in a high percentage of colon cancer cells, but not in normal colonic surface epithelium. CacyBP/SIP promoted the cell proliferation of colon cancer cells under both basal and gastrin stimulated conditions as shown by knockdown studies. Gastrin stimulation triggered the translocation of CacyBP/SIP to the nucleus, and enhanced interaction between CacyBP/SIP and SKP1, a key component of ubiquitination pathway which further mediated the proteasome-dependent degradation of p27kip1 protein. The gastrin induced reduction in p27kip1 was prevented when cells were treated with the proteasome inhibitor MG132. These results suggest that CacyBP/SIP may be promoting growth of colon cancer cells by enhancing ubiquitin-mediated degradation of p27kip1.

  15. Lateral load performance of SIP walls with full bearing

    Science.gov (United States)

    Boren Yeh; Tom Skaggs; Xiping Wang; Tom Williamson

    2018-01-01

    The purpose of this study was to develop test data needed to characterize lateral load performance of structural insulated panel (SIP) walls with full bearing (restrained). The research program involved structural testing of 29 full-size SIP walls (8 ft tall by 8 ft long) of various configurations that bracket a range of SIP wall configurations commonly used in the...

  16. Implementação de um sistema SIP para o sistema operacional Linux

    OpenAIRE

    Davison Gonzaga da Silva

    2003-01-01

    Resumo: Este trabalho apresenta a implementação de um Sistema de VoIP usando o Protocolo SIP. Este Sistema SIP foi desenvolvido para o Linux, usando-se a linguagem C++ em conjunto com a biblioteca QT. O Sistema SIP é composto de três entidades básicas: o Terminal SIP, o Proxy e o Servidor de Registros. O Terminal SIP é a entidade responsável por estabelecer sessões SIP com outros Terminais SIP. Para o Terminal SIP, foi desenvolvida uma biblioteca de acesso à placa de áudio, que permite a modi...

  17. The Water SWITCH-ON Spatial Information Platform (SIP)

    Science.gov (United States)

    Sala Calero, J., Sr.; Boot, G., Sr.; Dihé, P., Sr.; Arheimer, B.

    2017-12-01

    The amount of hydrological open data is continually growing and providing opportunities to the scientific community. Although the existing data portals (GEOSS Portal, INSPIRE community geoportal and others) enable access to open data, many users still find browsing through them difficult. Moreover, the time spent on gathering and preparing data usually is more significant than the time spent on the experiment itself. Thus, any improvement on searching, understanding, accessing or using open data is greatly beneficial. The Spatial Information Platform (SIP) has been developed to tackle these issues within the SWITCH-ON European Commission funded FP7 project. The SIP has been designed as a set of tools based on open standards that provide to the user all the necessary functionalities as described in the Publish-Find-Bind (PFB) pattern. In other words, this means that the SIP helps users to locate relevant and suitable data for their experiments analysis, to access and transform it (filtering, extraction, selection, conversion, aggregation). Moreover, the SIP can be used to provide descriptive information about the data and to publish it so others can find and use it. The SIP is based on existing open data protocols such as the OGC/CSW, OGC/WMS, OpenDAP and open-source components like PostgreSQL/PostGIS, GeoServer and pyCSW. The SIP is divided in three main user interfaces: the BYOD (Browse your open dataset) web interface, the Expert GUI tool and the Upload Data and Metadata web interface. The BYOD HTML5 client is the main entry point for users that want to browse through open data in the SIP. The BYOD has a map interface based on Leaflet JavaScript libraries so that the users can search more efficiently. The web-based Open Data Registration Tool is a user-friendly upload and metadata description interface (geographical extent, license, DOI generation). The Expert GUI is a desktop application that provides full metadata editing capabilities for the metadata

  18. SIP: A Web-Based Astronomical Image Processing Program

    Science.gov (United States)

    Simonetti, J. H.

    1999-12-01

    I have written an astronomical image processing and analysis program designed to run over the internet in a Java-compatible web browser. The program, Sky Image Processor (SIP), is accessible at the SIP webpage (http://www.phys.vt.edu/SIP). Since nothing is installed on the user's machine, there is no need to download upgrades; the latest version of the program is always instantly available. Furthermore, the Java programming language is designed to work on any computer platform (any machine and operating system). The program could be used with students in web-based instruction or in a computer laboratory setting; it may also be of use in some research or outreach applications. While SIP is similar to other image processing programs, it is unique in some important respects. For example, SIP can load images from the user's machine or from the Web. An instructor can put images on a web server for students to load and analyze on their own personal computer. Or, the instructor can inform the students of images to load from any other web server. Furthermore, since SIP was written with students in mind, the philosophy is to present the user with the most basic tools necessary to process and analyze astronomical images. Images can be combined (by addition, subtraction, multiplication, or division), multiplied by a constant, smoothed, cropped, flipped, rotated, and so on. Statistics can be gathered for pixels within a box drawn by the user. Basic tools are available for gathering data from an image which can be used for performing simple differential photometry, or astrometry. Therefore, students can learn how astronomical image processing works. Since SIP is not part of a commercial CCD camera package, the program is written to handle the most common denominator image file, the FITS format.

  19. Design of a SIP device cooperation system on OSGi service platforms

    Science.gov (United States)

    Takayama, Youji; Koita, Takahiro; Sato, Kenya

    2007-12-01

    Home networks feature such various technologies as protocols, specifications, and middleware, including HTTP, UPnP, and Jini. A service platform is required to handle such technologies to enable them to cooperate with different devices. The OSGi service platform, which meets the requirements based on service-oriented architecture, is designed and standardized by OSGi Alliance and consists of two parts: one OSGi Framework and bundles. On the OSGi service platform, APIs are defined as services that can handle these technologies and are implemented in the bundle. By using the OSGi Framework with bundles, various technologies can cooperate with each other. On the other hand, in IP networks, Session Initiation Protocol (SIP) is often used in device cooperation services to resolve an IP address, control a session between two or more devices, and easily exchange the statuses of devices. However, since many existing devices do not correspond to SIP, it cannot be used for device cooperation services. A device that does not correspond to SIP is called an unSIP device. This paper proposes and implements a prototype system that enables unSIP devices to correspond to SIP. For unSIP devices, the proposed system provides device cooperation services with SIP.

  20. A Survey of Open Source Products for Building a SIP Communication Platform

    Directory of Open Access Journals (Sweden)

    Pavel Segec

    2011-01-01

    Full Text Available The Session Initiation Protocol (SIP is a multimedia signalling protocol that has evolved into a widely adopted communication standard. The integration of SIP into existing IP networks has fostered IP networks becoming a convergence platform for both real-time and non-real-time multimedia communications. This converged platform integrates data, voice, video, presence, messaging, and conference services into a single network that offers new communication experiences for users. The open source community has contributed to SIP adoption through the development of open source software for both SIP clients and servers. In this paper, we provide a survey on open SIP systems that can be built using publically available software. We identify SIP features for service development and programming, services and applications of a SIP-converged platform, and the most important technologies supporting SIP functionalities. We propose an advanced converged IP communication platform that uses SIP for service delivery. The platform supports audio and video calls, along with media services such as audio conferences, voicemail, presence, and instant messaging. Using SIP Application Programming Interfaces (APIs, the platform allows the deployment of advanced integrated services. The platform is implemented with open source software. Architecture components run on standardized hardware with no need for special purpose investments.

  1. A methodology of SiP testing based on boundary scan

    Science.gov (United States)

    Qin, He; Quan, Haiyang; Han, Yifei; Zhu, Tianrui; Zheng, Tuo

    2017-10-01

    System in Package (SiP) play an important role in portable, aerospace and military electronic with the microminiaturization, light weight, high density, and high reliability. At present, SiP system test has encountered the problem on system complexity and malfunction location with the system scale exponentially increase. For SiP system, this paper proposed a testing methodology and testing process based on the boundary scan technology. Combining the character of SiP system and referencing the boundary scan theory of PCB circuit and embedded core test, the specific testing methodology and process has been proposed. The hardware requirement of the under test SiP system has been provided, and the hardware platform of the testing has been constructed. The testing methodology has the character of high test efficiency and accurate malfunction location.

  2. DNA stable-isotope probing (DNA-SIP).

    Science.gov (United States)

    Dunford, Eric A; Neufeld, Josh D

    2010-08-02

    DNA stable-isotope probing (DNA-SIP) is a powerful technique for identifying active microorganisms that assimilate particular carbon substrates and nutrients into cellular biomass. As such, this cultivation-independent technique has been an important methodology for assigning metabolic function to the diverse communities inhabiting a wide range of terrestrial and aquatic environments. Following the incubation of an environmental sample with stable-isotope labelled compounds, extracted nucleic acid is subjected to density gradient ultracentrifugation and subsequent gradient fractionation to separate nucleic acids of differing densities. Purification of DNA from cesium chloride retrieves labelled and unlabelled DNA for subsequent molecular characterization (e.g. fingerprinting, microarrays, clone libraries, metagenomics). This JoVE video protocol provides visual step-by-step explanations of the protocol for density gradient ultracentrifugation, gradient fractionation and recovery of labelled DNA. The protocol also includes sample SIP data and highlights important tips and cautions that must be considered to ensure a successful DNA-SIP analysis.

  3. Thermo-physical properties of reproducible Sip/Al composites

    Institute of Scientific and Technical Information of China (English)

    XIU Zi-yang; WU Gao-hui; SONG Mei-hui; ZHU De-zhi

    2006-01-01

    Three kinds of high volume fraction Sip/1199, Sip/4032 and Sip/4019 composites were fabricated by squeeze casting method. The results show that the clean Si/Al interfaces without interfacial reaction products can decrease the interfacial thermal resistance. The composites have a low coefficient of thermal expansion (7.5×10-6 ℃-1) and high thermal conductivity ranging from 126 to 157.9 W/(m ℃). With increasing temperature, the specific capacity and the average coefficient of thermal expansion increases monotonically, the thermal diffusivity and the thermal conductivity decrease gradually. The specific capacity, average coefficient of thermal expansion, thermal diffusivity and the thermal conductivity of the composites decrease gradually with increasing Si content.The thermal conductivities of composites were calculated by theoretical models. Both Maxwell model and P.G model consider the reinforcement as nearly-round particles, and the interface thermal resistance of Sip/Al composite calculated by EMA method is 0.01×10-6m2.℃/W

  4. Flux-Enabled Exploration of the Role of Sip1 in Galactose Yeast Metabolism

    Directory of Open Access Journals (Sweden)

    Christopher M. Shymansky

    2017-05-01

    Full Text Available 13C metabolic flux analysis (13C MFA is an important systems biology technique that has been used to investigate microbial metabolism for decades. The heterotrimer Snf1 kinase complex plays a key role in the preference Saccharomyces cerevisiae exhibits for glucose over galactose, a phenomenon known as glucose repression or carbon catabolite repression. The SIP1 gene, encoding a part of this complex, has received little attention, presumably, because its knockout lacks a growth phenotype. We present a fluxomic investigation of the relative effects of the presence of galactose in classically glucose-repressing media and/or knockout of SIP1 using a multi-scale variant of 13C MFA known as 2-Scale 13C metabolic flux analysis (2S-13C MFA. In this study, all strains have the galactose metabolism deactivated (gal1Δ background so as to be able to separate the metabolic effects purely related to glucose repression from those arising from galactose metabolism. The resulting flux profiles reveal that the presence of galactose in classically glucose-repressing conditions, for a CEN.PK113-7D gal1Δ background, results in a substantial decrease in pentose phosphate pathway (PPP flux and increased flow from cytosolic pyruvate and malate through the mitochondria toward cytosolic branched-chain amino acid biosynthesis. These fluxomic redistributions are accompanied by a higher maximum specific growth rate, both seemingly in violation of glucose repression. Deletion of SIP1 in the CEN.PK113-7D gal1Δ cells grown in mixed glucose/galactose medium results in a further increase. Knockout of this gene in cells grown in glucose-only medium results in no change in growth rate and a corresponding decrease in glucose and ethanol exchange fluxes and flux through pathways involved in aspartate/threonine biosynthesis. Glucose repression appears to be violated at a 1/10 ratio of galactose-to-glucose. Based on the scientific literature, we may have conducted our experiments

  5. Heterologous protein secretion in Lactobacilli with modified pSIP vectors.

    Directory of Open Access Journals (Sweden)

    Ingrid Lea Karlskås

    Full Text Available We describe new variants of the modular pSIP-vectors for inducible gene expression and protein secretion in lactobacilli. The basic functionality of the pSIP system was tested in Lactobacillus strains representing 14 species using pSIP411, which harbors the broad-host-range Lactococcus lactis SH71rep replicon and a β-glucuronidase encoding reporter gene. In 10 species, the inducible gene expression system was functional. Based on these results, three pSIP vectors with different signal peptides were modified by replacing their narrow-host-range L. plantarum 256rep replicon with SH71rep and transformed into strains of five different species of Lactobacillus. All recombinant strains secreted the target protein NucA, albeit with varying production levels and secretion efficiencies. The Lp_3050 derived signal peptide generally resulted in the highest levels of secreted NucA. These modified pSIP vectors are useful tools for engineering a wide variety of Lactobacillus species.

  6. A Stepwise Approach to Developing Languages for SIP Telephony Service Creation

    DEFF Research Database (Denmark)

    Palix, Nicolas; Consel, Charles; Reveillere, Laurent

    2007-01-01

    Developing a SIP-based telephony service requires a programmer to have expertise in telephony rules and constraints, the SIP protocol, distributed systems, and a SIP API, which is often large and complex. These requirements make the development of telephony software an overwhelming challenge...... a scripting language dedicated to the development of telephony services. This approach enables critical properties of services to be guaranteed and captures expertise on the operational behavior of a service. We have applied this approach to developing the Session Processing Language (SPL) dedicated to SIP...

  7. Stream Control Transmission Protocol as a Transport for SIP: a case study

    Directory of Open Access Journals (Sweden)

    Giuseppe De Marco

    2004-06-01

    Full Text Available The dominant signalling protocol both in future wireless and wired networks will be the Session Initiation Protocol (SIP, as pointed out in the 3G IP-based mobile networks specifications, entailing a fully Internet integrated network. The use of SIP in the IP Multimedia Subsytem (IMS of Release 5 involves the development of servers capable to handle a large number of call requests. The signaling traffic associated to such requests could explode, if an intelligent congestion control were not introduced. Stream Control Transmission Protocol (SCTP was born to support transport of SS7 signaling messages. However, many of the SCTP features are also useful for transport of SIP messages, as: congestion control mechanism, good separation among independent messages, multihoming. Indeed, adoption of SCTP as transport of SIP signaling might prove useful in some situations where usual transport protocols, like TCP and UDP, suffer performance degradation. In this paper, we analyse the general framework wherein SIP operates and we discuss the benefits of using SCTP as a transport for SIP, toward fair sharing of network resources. This study is carried on in the context of the implementation of an high-performance SIP Proxy Server. We also present some preliminar results of an implementation of SIP over SCTP/UDP in a real LAN environment.

  8. SIP Signaling Implementations and Performance Enhancement over MANET: A Survey

    OpenAIRE

    Alshamrani, M; Cruickshank, Haitham; Sun, Zhili; Ansa, G; Alshahwan, F

    2016-01-01

    The implementation of the Session Initiation Protocol (SIP)-based Voice over Internet Protocol (VoIP) and multimedia over MANET is still a challenging issue. Many routing factors affect the performance of SIP signaling and the voice Quality of Service (QoS). Node mobility in MANET causes dynamic changes to route calculations, topology, hop numbers, and the connectivity status between the correspondent nodes. SIP-based VoIP depends on the caller’s registration, call initiation, and call termin...

  9. 75 FR 32190 - Disease, Disability, and Injury Prevention and Control Special Interest Projects (SIPs...

    Science.gov (United States)

    2010-06-07

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and Control Special Interest Projects (SIPs): Examining the Impact of... Advisory Committee Act (Pub. L. 92-463), the Centers for Disease Control and Prevention (CDC) announces the...

  10. The SIP express router: An open source SIP platform: Presentation held at EVOLUTE - seamlEss multimedia serVices Over alL IP-based infrastrUcTurEs Workshop, 10. November 2003, Guildford, UK

    OpenAIRE

    Rebahi, Y.; Sisalem, D.; Kuthan, J.; Pelinescu-Oncicul, A.; Iancu, B.; Janak, J.; Mierla, D.C.

    2003-01-01

    The session initiation protocol (SIP) is constantly gaining in popularity and acceptance as the signaling protocol for next generation multimedia communication. This paper describes a scalable and reliable open source SIP platform called the SIP Express Router (SER). SER does not only support basic SIP features but also advanced features such as messaging and presence, translation between SIP and SMS or Jabber as well as full featured application programming interfaces. In this paper we will ...

  11. Deployment of SIP in MANET: challenges and circumvention

    Directory of Open Access Journals (Sweden)

    Abdelhamid Salma R.

    2017-01-01

    Full Text Available The immense growth in wireless network applications has encouraged the researchers to enhance and propose new approaches that facilitate the deployment of the widely used services, protocols, and applications of the wired networking area in the wireless networks. Among which, the Session Initiation Protocol (SIP is a signaling protocol that allows the establishment of multimedia sessions and calls between different parties. SIP functionality totally depends on a centralized infrastructure, and complexity arises when deploying such a protocol in a special type of wireless networks, namely Mobile Ad-hoc Networks (MANET, due to the absence of a centralized infrastructure, and the dynamic topology of the later. This paper highlights the the challenges arising when deploying SIP in MANETs and presents an overview of different proposed approaches to overcome these challenges.

  12. Testing Dialog-Verification of SIP Phones with Single-Message Denial-of-Service Attacks

    Science.gov (United States)

    Seedorf, Jan; Beckers, Kristian; Huici, Felipe

    The Session Initiation Protocol (SIP) is widely used for signaling in multimedia communications. However, many SIP implementations are still in their infancy and vulnerable to malicious messages. We investigate flaws in the SIP implementations of eight phones, showing that the deficient verification of SIP dialogs further aggravates the problem by making it easier for attacks to succeed. Our results show that the majority of the phones we tested are susceptible to these attacks.

  13. Improvement of the Response Time in an Open Source Audioconference Architecture Based on SIP Multicast Implemented with JainSIP, JainSDP and JGAP Libraries

    Directory of Open Access Journals (Sweden)

    Carlos M. Moreno

    2014-06-01

    Full Text Available Group services like the audioconference require a minimum level of quality of service for multicast sessions. This work proposes a new overlay multicast architecture based on SIP extensions and a genetic algorithm. The architecture consists of a SIP Extender client (SE, a Multicast Gateway Agent (MGA and a Multicast Manager (MM. The SE receives information about the most adequate MGA for it determined by a genetic algorithm inside the MM, then connects the chosen MGA and maintains connection with the MM itself. The genetic algorithm is implemented with JGAP(Java Genetic Algorithm Package libraries. The SE and MGA are programmed with JainSIP and JainSDP libraries which contain Java structures associated with the SIP protocol and session description. Some experiments over UTP wired and WiFi IEEE802.11n network were performed. Partial results with static and dynamic MGA selection show that, if we compare the joining and leaving time measured inside a station containing SE client programmed with JainSIP and JainSDP libraries versus SJphone proprietary client, the software engineering may have more influence than the medium access method in the response time for a potential group member. Even more, the genetic algorithm at the MM minimizes the response time at great scale.

  14. Creep Behavior of Structural Insulated Panels (SIPS): Results from a Pilot Study

    Science.gov (United States)

    Dwight McDonald; Marshall Begel; C. Adam Senalik; Robert Ross; Thomas D. Skaggs; Borjen Yeh; Thomas Williamson

    2014-01-01

    Structural insulated panels (SIPs) have been recognized as construction materials in the International Residential Code (IRC) since 2009. Although most SIPs are used in wall applications, they can also be used as roof or floor panels that are subjected to long-term transverse loading, for which SIP creep performance may be critical in design. However, limited...

  15. Self-image profile in children and adolescents with attention deficit/ hyperactivity disorder and the quality of life in their parents.

    Science.gov (United States)

    Gormez, Vahdet; Forbes, Fiona C M

    2015-01-01

    We explored the impact of clinical response to treatment for Attention Deficit/Hyperactivity Disorder (ADHD) in children and adolescents on the subsequent changes in their self-image profile, the quality of life of their parents, and its effect on socio-demographic variables. Conners Rating Scales for Parents (CPRS-R) and for Teachers (CTRS-R) completed at the time of entry to the service were repeated to measure clinical response to treatment; the Self-image Profiles for Children (SIP-C) and Adolescents (SIP-A), the World Health Organization Quality of Life (WHOQoL) questionnaire and postcode data were used to evaluate other domains. Data was collected for 53 boys (84%) and 10 girls (16%) with current mean age 11.5 years. Four-fifths (51/63) received pharmacological treatment and all parents were offered group parent training program. The only subscale in CPRS-R to show significance was the ADHD Index. The CTRS-R demonstrated statistically significant improvement (p Self-image Profile, children reported themselves as more Kind (p Self-image Profile of children and adolescents, but its impact on the QoL in parents was limited. © 2015 The Author(s).

  16. A lightweight privacy preserving authenticated key agreement protocol for SIP-based VoIP

    OpenAIRE

    Zhang, Liping; Tang, Shanyu; Zhu, Shaohui

    2016-01-01

    Session Initiation Protocol (SIP) is an essential part of most Voice over Internet Protocol (VoIP) architecture. Although SIP provides attractive features, it is exposed to various security threats, and so an efficient and secure authentication scheme is sought to enhance the security of SIP. Several attempts have been made to address the tradeoff problem between security and efficiency, but designing a successful authenticated key agreement protocol for SIP is still a challenging task from t...

  17. Nationwide SIP Telephony Network Design to Prevent Congestion Caused by Disaster

    Science.gov (United States)

    Satoh, Daisuke; Ashitagawa, Kyoko

    We present a session initiation protocol (SIP) network design for a voice-over-IP network to prevent congestion caused by people calling friends and family after a disaster. The design increases the capacity of SIP servers in a network by using all of the SIP servers equally. It takes advantage of the fact that equipment for voice data packets is different from equipment for signaling packets in SIP networks. Furthermore, the design achieves simple routing on the basis of telephone numbers. We evaluated the performance of our design in preventing congestion through simulation. We showed that the proposed design has roughly 20 times more capacity, which is 57 times the normal load, than the conventional design if a disaster were to occur in Niigata Prefecture struck by the Chuetsu earthquake in 2004.

  18. Targeting Unknowns Just Underfoot: Microbial Ecology and Community Genomics of C Cycling in Soil Informed and Enabled with DNA-SIP

    Science.gov (United States)

    Pepe-Ranney, C. P.; Campbell, A.; Buckley, D. H.

    2015-12-01

    Microorganisms drive biogeochemical cycles and because soil is a large global carbon (C) reservoir (soil contains more C than plants and the atmosphere combined), soil microorganisms are important players in the global C-cycle. Frustratingly, however, many soil microorganisms resist cultivation and soil communities are astoundingly complex. This makes soil microbiology difficult to study and without a solid understanding of soil microbial ecology, models of soil C feedbacks to climate change are under-informed. Stable isotope probing (SIP) is a useful approach for establishing identity-function connections in microbial communities but has been challenging to employ in soil due to the inadequate resolution of microbial community fingerprinting techniques. High throughput DNA sequencing improves SIP resolving power transforming it into a powerful tool for studying the soil C cycle. We conducted a DNA-SIP experiment to track flow of xylose-C, a labile component of plant biomass, and cellulose-C, the most abundant global biopolymer, through a soil microbial community. We could track 13C into microbial DNA even when added 13C amounted to less than 5% of native C and found Spartobacteria, Chloroflexi, and Planctomycetes taxa were among those that assimilated 13C cellulose. These lineages are cosmopolitan in soil but little is known of their ecophysiology. By profiling SSU rRNA genes across entire DNA-SIP density gradients, we assessed relative DNA atom % 13C per taxon in 13C treatments and found cellulose degraders exhibited signal consistent with a specialist lifestyle with respect to C preference. Further, DNA-SIP enriches DNA of targeted microorganisms (Verrucomicrobia cellulose degraders were enriched by nearly two orders of magnitude) and this enriched DNA can serve as template for community genomics. We produced draft genomes from soil cellulose degraders including microorganisms belonging to Verrucomicrobia, Chloroflexi, and Planctomycetes from SIP enriched DNA

  19. Gest-sip1 experiments and post-test calculations with the relap5 code

    International Nuclear Information System (INIS)

    Achilli, A.; Cattadori, G.; Ferri, R.; Gandolfi, S.; Bianchi, F.; Meloni, P.

    2001-01-01

    The SIP-1 apparatus (Sistema di Iniezione Passiva) was conceived, designed, numerically simulated and tested by the SIET company as an innovative depressurization and make-up device for the New Generation LWRs. In particular it is suitable to cope with those accidents where pressure in the circuit must be dumped to allow low pressure injection systems to intervene. The main peculiarity of SIP-1 is the capability of de-pressurizing a system by cold water injection, rather than by discharging mass to the outlet, as in the common depressurization systems. ENEA sponsored all the research activity, starting from the SIP-1 design, its numerical simulation with the Relap5 code, the realisation of an experimental facility up to the test execution and post-test calculations. An experimental campaign on the GEST-SIP1 facility was performed in July 2000. The facility is mainly constituted by a U-tube Steam Generator which a proper model of SIP-1 apparatus is connected to. A series of Small Break LOCAs was simulated by varying the break size and different steady conditions were investigated to verify the stability of SIP-1, the lack of unexpected interventions and the actuation modalities. This paper deals with the description of the GEST-SIP1 experimental facility, the SIP-1 operating principles, the most meaningful results of the tests and the capability of the Relap5 code in reproducing phenomena and events. (author)

  20. Overexpressed CacyBP/SIP leads to the suppression of growth in renal cell carcinoma

    International Nuclear Information System (INIS)

    Sun, Shiren; Ning, Xiaoxuan; Liu, Jie; Liu, Lili; Chen, Yu; Han, Shuang; Zhang, Yanqi; Liang, Jie; Wu, Kaichun; Fan, Daiming

    2007-01-01

    Calcyclin-binding protein/Siah-1-interacting protein (CacyBP/SIP), a target protein of S100, has been identified as a component of a novel ubiquitinylation complex leading to β-catenin degradation, which was found to be related to the malignant phenotypes of gastric cancer. However, the roles of CacyBP/SIP in renal cell carcinoma still remain unclear. In the present study, we had analyzed the expression of the CacyBP/SIP protein in human renal cancer cells and clinical tissue samples. The possible roles of CacyBP/SIP in regulating the malignant phenotype of renal cancer cells were also investigated. The results demonstrated that the expression of CacyBP/SIP was markedly down-regulated in renal cell carcinoma tissues and cell lines. Ectopic overexpression of CacyBP/SIP in A498 cells inhibited the proliferation of this cell and delayed cell cycle progression significantly, which might be related to the down-regulation of Cyclin D1 through reducing β-catenin protein. CacyBP/SIP also suppressed colony formation in soft agar and its tumorigenicity in nude mice. Taken together, our work showed that CacyBP/SIP, as a novel down-regulated gene in renal cell carcinoma, suppressed proliferation and tumorigenesis of renal cancer cells

  1. A combined wet/dry sipping cell for investigating failed triga fuel elements

    International Nuclear Information System (INIS)

    Boeck, H.; Gallhammer, H.; Hammer, J.; Israr, M.

    1987-08-01

    A sipping cell to detect failed triga fuel has been designed and constructed at the Atominstitut. The cell allows both wet- and dry sipping of one single standard triga fuel element. In the dry sipping method the fuel element may be electrically heated up to a maximum temperature of about 300 0 C to allow the detection of temperature dependent fission product release from the fuel element. 20 figs., 1 tab. (Author)

  2. On SIP Session setup delay for VoIP services over correlated fading channels

    DEFF Research Database (Denmark)

    Fathi, Hanane; Chakraborty, Shyam S.; Prasad, Ramjee

    2006-01-01

    In this paper, the session setup delay of the session initiation protocol (SIP) is studied. The transmissions on both the forward and reverse channel are assumed to experience Markovian errors. The session setup delay is evaluated for different transport protocols, and with the use of the radio...... link protocol (RLP). An adaptive retransmission timer is used to optimize SIP performances. Using numerical results, we find that SIP over user datagram protocol (UDP) instead of transport control protocol (TCP) can make the session setup up to 30% shorter. Also, RLP drastically reduces the session...... setup delay down to 4 to 5 s, even in environments with high frame error rates (10%) and significant correlation in the fading process (fDT=0.02). SIP is compared with its competitor H.323. SIP session setup delay with compressed messages outperforms H.323 session setup delay....

  3. Plasma cleaning and analysis of archeological artefacts from Sipán

    Science.gov (United States)

    Saettone, E. A. O.; da Matta, J. A. S.; Alva, W.; Chubaci, J. F. O.; Fantini, M. C. A.; Galvão, R. M. O.; Kiyohara, P.; Tabacniks, M. H.

    2003-04-01

    A novel procedure using plasma sputtering in an electron-cyclotron-resonance device has been applied to clean archeological MOCHE artefacts, unearthed at the Royal Tombs of Sipán. After successful cleaning, the pieces were analysed by a variety of complementary techniques, namely proton-induced x-ray emission, Rutherford backscattering spectroscopy, x-ray diffraction, electron microscopy, and inductively coupled plasma mass spectroscopy. With these techniques, it has been possible to not only determine the profiles of the gold and silver surface layers, but also to detect elements that may be relevant to explain the gilding techniques skillfully developed by the metal smiths of the MOCHE culture.

  4. 78 FR 21281 - Approval and Promulgation of Implementation Plans; State of Missouri; Infrastructure SIP...

    Science.gov (United States)

    2013-04-10

    ... existing SIP provisions for this purpose. Instead, EPA is only evaluating whether the state's SIP has basic...) requires SIPs to include provisions to provide for establishment and operation of ambient air quality..., restaurants, etc. triggering GHG PSD requirements. On December 23, 2010, EPA promulgated a subsequent series...

  5. A Secured Authentication Protocol for SIP Using Elliptic Curves Cryptography

    Science.gov (United States)

    Chen, Tien-Ho; Yeh, Hsiu-Lien; Liu, Pin-Chuan; Hsiang, Han-Chen; Shih, Wei-Kuan

    Session initiation protocol (SIP) is a technology regularly performed in Internet Telephony, and Hyper Text Transport Protocol (HTTP) as digest authentication is one of the major methods for SIP authentication mechanism. In 2005, Yang et al. pointed out that HTTP could not resist server spoofing attack and off-line guessing attack and proposed a secret authentication with Diffie-Hellman concept. In 2009, Tsai proposed a nonce based authentication protocol for SIP. In this paper, we demonstrate that their protocol could not resist the password guessing attack and insider attack. Furthermore, we propose an ECC-based authentication mechanism to solve their issues and present security analysis of our protocol to show that ours is suitable for applications with higher security requirement.

  6. Minimizing SIP Session Re-Setup Delay over Wireless Link in 3G Handover Scenarios

    Directory of Open Access Journals (Sweden)

    Moon Bongkyo

    2010-01-01

    Full Text Available The delay in transmitting SIP messages over the wireless link for session resetup at handover is still major bottleneck for interactive multimedia service. In this paper, a proxy agent-based scheme is proposed to minimize the SIP session setup delay over a wireless link in 3G inter-subnet handover scenarios. This scheme is based on the two characteristics. One is that the major factor of SIP session re-setup delay is generally caused by the retransmissions in the unreliable wireless links, and the other is that most of the fields in request messages as well as response messages are duplicated when a set of SIP messages are exchanged during session re-setup procedure. In this scheme, no change is required in the SIP message processing except for the proxy agents in both BS and MH.

  7. Comparison of artificial intelligence classifiers for SIP attack data

    Science.gov (United States)

    Safarik, Jakub; Slachta, Jiri

    2016-05-01

    Honeypot application is a source of valuable data about attacks on the network. We run several SIP honeypots in various computer networks, which are separated geographically and logically. Each honeypot runs on public IP address and uses standard SIP PBX ports. All information gathered via honeypot is periodically sent to the centralized server. This server classifies all attack data by neural network algorithm. The paper describes optimizations of a neural network classifier, which lower the classification error. The article contains the comparison of two neural network algorithm used for the classification of validation data. The first is the original implementation of the neural network described in recent work; the second neural network uses further optimizations like input normalization or cross-entropy cost function. We also use other implementations of neural networks and machine learning classification algorithms. The comparison test their capabilities on validation data to find the optimal classifier. The article result shows promise for further development of an accurate SIP attack classification engine.

  8. CacyBP/SIP binds ERK1/2 and affects transcriptional activity of Elk-1

    International Nuclear Information System (INIS)

    Kilanczyk, Ewa; Filipek, Slawomir; Jastrzebska, Beata; Filipek, Anna

    2009-01-01

    In this work we showed for the first time that mouse CacyBP/SIP interacts with extracellular signal regulated kinases 1 and 2 (ERK1/2). We also established that a calcium binding protein, S100A6, competes for this interaction. Moreover, the E217K mutant of CacyBP/SIP does not bind significantly to ERK1/2 although it retains the ability to interact with S100A6. Molecular modeling shows that the E217K mutation in the 189-219 CacyBP/SIP fragment markedly changes its electrostatic potential, suggesting that the binding with ERK1/2 might have an electrostatic character. We also demonstrate that CacyBP/SIP-ERK1/2 interaction inhibits phosphorylation of the Elk-1 transcription factor in vitro and in the nuclear fraction of NB2a cells. Altogether, our data suggest that the binding of CacyBP/SIP with ERK1/2 might regulate Elk-1 phosphorylation/transcriptional activity and that S100A6 might further modulate this effect via Ca 2+ -dependent interaction with CacyBP/SIP and competition with ERK1/2.

  9. Spectral induced polarization (SIP) response of mine tailings.

    Science.gov (United States)

    Placencia-Gómez, Edmundo; Parviainen, Annika; Slater, Lee; Leveinen, Jussi

    2015-02-01

    Mine tailings impoundments are a source of leachates known as acid mine drainage (AMD) which can pose a contamination risk for surrounding surface and groundwater. Methodologies which can help management of this environmental issue are needed. We carried out a laboratory study of the spectral induced polarization (SIP) response of tailings from the Haveri Au-Cu mine, SW Finland. The primary objectives were, (1) to determine possible correlations between SIP parameters and textural properties associated with oxidative-weathering mechanisms, mineralogical composition and metallic content, and (2) to evaluate the effects of the pore water chemistry on SIP parameters associated with redox-inactive and redox-active electrolytes varying in molar concentration, conductivity and pH. The Haveri tailings exhibit well defined relaxation spectra between 100 and 10,000Hz. The relaxation magnitudes are governed by the in-situ oxidative-weathering conditions on sulphide mineral surfaces contained in the tailings, and decrease with the oxidation degree. The oxidation-driven textural variation in the tailings results in changes to the frequency peak of the phase angle, the imaginary conductivity and chargeability, when plotted versus the pore water conductivity. In contrast, the real and the formation electrical conductivity components show a single linear dependence on the pore water conductivity. The increase of the pore water conductivity (dominated by the increase of ions concentration in solution) along with a transition to acidic conditions shifts the polarization peak towards higher frequencies. These findings show the unique sensitivity of the SIP method to potentially discriminate AMD discharges from reactive oxidation zones in tailings, suggesting a significant advantage for monitoring threatened aquifers. Copyright © 2014 Elsevier B.V. All rights reserved.

  10. The SHIP: A SIP to HTTP Interaction Protocol

    Science.gov (United States)

    Zeiß, Joachim; Gabner, Rene; Bessler, Sandford; Happenhofer, Marco

    IMS is capable of providing a wide range of services. As a result, terminal software becomes more and more complex to deliver network intelligence to user applications. Currently mobile terminal software needs to be permanently updated so that the latest network services and functionality can be delivered to the user. In the Internet, browser based user interfaces assure that an interface is made available to the user which offers the latest services in the net immediately. Our approach combines the benefits of the Session Initiation Protocol (SIP) and those of the HTTP protocol to bring the same type of user interfacing to IMS. SIP (IMS) realizes authentication, session management, charging and Quality of Service (QoS), HTTP provides access to Internet services and allows the user interface of an application to run on a mobile terminal while processing and orchestration is done on the server. A SHIP enabled IMS client only needs to handle data transport and session management via SIP, HTTP and RTP and render streaming media, HTML and Javascript. SHIP allows new kinds of applications, which combine audio, video and data within a single multimedia session.

  11. Comparison of H.323 and SIP for IP telephony signaling

    Science.gov (United States)

    Dalgic, Ismail; Fang, Hanlin

    1999-11-01

    Two standards currently compete for the dominance of IP telephony signaling: the H.323 protocol suite by ITU-T, and the Session Initiation Protocol (SIP) by IETF. Both of these signaling protocols provide mechanisms for call establishment and teardown, call control and supplementary services, and capability exchange. We investigate and compare these two protocols in terms of Functionality, Quality of Service (QoS), Scalability, Flexibility, Interoperability, and Ease of Implementation. For fairness of comparison, we consider similar scenarios for both protocols. In particular, we focus on scenarios that involve a gatekeeper for H.323, and a Proxy/Redirect server for SIP. The reason is that medium-to-large IP Telephony systems are not manageable without a gatekeeper or proxy server. We consider all three versions of H.323. In terms of functionality and services that can be supported, H.323 version 2 and SIP are very similar. However, supplementary services in H.323 are more rigorously defined, and therefore fewer interoperability issues are expected among its implementations. Furthermore, H.323 has taken more steps to ensure compatibility among its different versions, and to interoperate with PSTN. The two protocols are comparable in their QoS support [similar call setup delays, no support for resource reservation or class of service (CoS) setting], but H.323 version 3 will allow signaling of the requested CoS. SIP's primary advantages are (1) flexibility to add new features, and (2) relative ease of implementation and debugging. Finally, we note that H.323 and SIP are improving themselves by learning from each other, and the differences between them are diminishing with each new version.

  12. 'SIP', as a tool of 'Ukrytie' shelter transformation into an ecologically safe system

    International Nuclear Information System (INIS)

    Dzhadd, K.; Shmidt, D.

    1999-01-01

    The Shelter implementation plan (SIP) was used for realisation of 'Ukrytie' stabilization and for its transformation into an ecologically safe system SIP includes logic of needed actions and process of solution adaption during 'Ukrytie' transformation

  13. Relevance of phosphorus incorporation and hydrogen removal for Si:P {delta}-doped layers fabricated using phosphine

    Energy Technology Data Exchange (ETDEWEB)

    Goh, K.E.J.; Oberbeck, L.; Simmons, M.Y. [Centre for Quantum Computer Technology, School of Physics, The University of New South Wales, Sydney, New South Wales 2052 (Australia)

    2005-05-01

    We present a study to determine the importance of phosphorus incorporation and hydrogen removal for the electrical activation of phosphorus dopants in Si:P {delta}-doped samples fabricated using phosphine dosing and molecular beam epitaxy (MBE). The carrier densities in these samples were determined from Hall effect measurements at 4 K sample temperature. An anneal to incorporate phosphorus atoms into substitutional lattice sites is critical to achieving full dopant activation after Si encapsulation by MBE. Whilst the presence of hydrogen can degrade the quality of the Si encapsulation layer, we show that it does not adversely impact the electrical activation of the phosphorus dopants. We discuss the relevance of our results to the fabrication of nano-scale Si:P devices. (copyright 2005 WILEY-VCH Verlag GmbH and C o. KGaA, Weinheim) (orig.)

  14. Impact of chronic cough on quality of life.

    Science.gov (United States)

    French, C L; Irwin, R S; Curley, F J; Krikorian, C J

    Cough is the most common complaint for which adult patients seek medical care in the United States; however, the reason(s) for this is unknown. To determine whether chronic cough was associated with adverse psychosocial or physical effects on the quality of life and whether the elimination of chronic cough with specific therapy improved these adverse effects. The study design was a prospective before-and-after intervention trial with patients serving as their own controls. Study subjects were a convenience sample of 39 consecutive and unselected adult patients referred for evaluation and management of a chronic, persistently troublesome cough. Baseline data were available for 39 patients and follow-up for 28 patients (22 women and 6 men). At baseline, demographic, Adverse Cough Outcome Survey (ACOS), and Sickness Impact Profile (SIP) data were collected and patients were managed according to a validated, systematic protocol. Following specific therapy for cough, ACOS and SIP instruments were readministered. The ages, sex, duration, and spectra and frequencies of the causes of cough were similar to multiple other studies. At baseline, patients reported a mean +/- SD of 8.6 +/- 4.8 types of adverse occurrences related to cough. There were significant correlations between multiple ACOS items and total, physical, and psychosocial SIP scores. Psychosocial score correlated with total number of symptoms (PSIP scores. Multiple linear regression analysis showed that 54% of variability of the psychosocial SIP score was explained by 4 ACOS items while none of the physical score was explained. Chronic cough was associated with deterioration in patients' quality of life. The health-related dysfunction was most likely psychosocial. The ACOS and SIP appear to be valid tools in assessing the impact of chronic cough.

  15. An IMS testbed for SIP applications

    DEFF Research Database (Denmark)

    Caba, Cosmin Marius; Soler, José

    2013-01-01

    The paper presents the design and implementation of an emulation platform for the IP Multimedia Subsystem. The SIP Servlet API v1.1 has been used to implement the final system. The purpose of the emulation is to offer to IMS service developers an environment where they can integrate development...

  16. Pumping characteristics of sputter ion pump (SIP) and titanium sublimation pump (TSP) combination

    International Nuclear Information System (INIS)

    Ratnakala, K.C.; Patel, R.J.; Bhavsar, S.T.; Pandiyar, M.L.; Ramamurthi, S.S.

    1995-01-01

    For achieving hydrocarbon free, clean ultra high vacuum, SIP-TSP combination is one of the ideal choice for pumping. For the SRS facility in Centre for Advanced Technology (CAT), we are utilising this combination, enmass. For this purpose, two modules of these combination set-ups are assembled, one with the TSP as an integral part of SIP and the other, with TSP as a separate pump mounted on the top of SIP. The pump bodies were vacuum degassed at 700 degC at 10 -5 mbar for 3 hrs. An ultimate vacuum of 3 x 10 -11 mbar was achieved, after a bake-out at 250 degC for 4 hrs, followed by continuous SIP pumping for 48 hrs, with two TSP flashing at approximately 10 hrs interval. The pump-down patterns as well as the pressure-rise patterns are studied. (author). 2 refs., 5 figs

  17. SMR-Based Adaptive Mobility Management Scheme in Hierarchical SIP Networks

    Directory of Open Access Journals (Sweden)

    KwangHee Choi

    2014-10-01

    Full Text Available In hierarchical SIP networks, paging is performed to reduce location update signaling cost for mobility management. However, the cost efficiency largely depends on each mobile node’s session-to-mobility-ratio (SMR, which is defined as a ratio of the session arrival rate to the movement rate. In this paper, we propose the adaptive mobility management scheme that can determine the policy regarding to each mobile node’s SMR. Each mobile node determines whether the paging is applied or not after comparing its SMR with the threshold. In other words, the paging is applied to a mobile node when a mobile node’s SMR is less than the threshold. Therefore, the proposed scheme provides a way to minimize signaling costs according to each mobile node’s SMR. We find out the optimal threshold through performance analysis, and show that the proposed scheme can reduce signaling cost than the existing SIP and paging schemes in hierarchical SIP networks.

  18. SIP-FS: a novel feature selection for data representation

    Directory of Open Access Journals (Sweden)

    Yiyou Guo

    2018-02-01

    Full Text Available Abstract Multiple features are widely used to characterize real-world datasets. It is desirable to select leading features with stability and interpretability from a set of distinct features for a comprehensive data description. However, most of existing feature selection methods focus on the predictability (e.g., prediction accuracy of selected results yet neglect stability. To obtain compact data representation, a novel feature selection method is proposed to improve stability, and interpretability without sacrificing predictability (SIP-FS. Instead of mutual information, generalized correlation is adopted in minimal redundancy maximal relevance to measure the relation between different feature types. Several feature types (each contains a certain number of features can then be selected and evaluated quantitatively to determine what types contribute to a specific class, thereby enhancing the so-called interpretability of features. Moreover, stability is introduced in the criterion of SIP-FS to obtain consistent results of ranking. We conduct experiments on three publicly available datasets using one-versus-all strategy to select class-specific features. The experiments illustrate that SIP-FS achieves significant performance improvements in terms of stability and interpretability with desirable prediction accuracy and indicates advantages over several state-of-the-art approaches.

  19. HTSSIP: An R package for analysis of high throughput sequencing data from nucleic acid stable isotope probing (SIP experiments.

    Directory of Open Access Journals (Sweden)

    Nicholas D Youngblut

    Full Text Available Combining high throughput sequencing with stable isotope probing (HTS-SIP is a powerful method for mapping in situ metabolic processes to thousands of microbial taxa. However, accurately mapping metabolic processes to taxa is complex and challenging. Multiple HTS-SIP data analysis methods have been developed, including high-resolution stable isotope probing (HR-SIP, multi-window high-resolution stable isotope probing (MW-HR-SIP, quantitative stable isotope probing (qSIP, and ΔBD. Currently, there is no publicly available software designed specifically for analyzing HTS-SIP data. To address this shortfall, we have developed the HTSSIP R package, an open-source, cross-platform toolset for conducting HTS-SIP analyses in a straightforward and easily reproducible manner. The HTSSIP package, along with full documentation and examples, is available from CRAN at https://cran.r-project.org/web/packages/HTSSIP/index.html and Github at https://github.com/buckleylab/HTSSIP.

  20. SIP-ing the elixir of youth.

    Science.gov (United States)

    Mair, William; Steffen, Kristan K; Dillin, Andrew

    2011-09-16

    AMP-activated protein kinase (AMPK) is a conserved cellular fuel gauge previously implicated in aging. In this issue, Lu et al. (2011) describe how age-related deacetylation of Sip2, a subunit of the AMPK homolog in yeast, acts as a life span clock that can be wound backward or forward to modulate longevity. Copyright © 2011 Elsevier Inc. All rights reserved.

  1. The Early Psychosis Screener (EPS): Quantitative validation against the SIPS using machine learning.

    Science.gov (United States)

    Brodey, B B; Girgis, R R; Favorov, O V; Addington, J; Perkins, D O; Bearden, C E; Woods, S W; Walker, E F; Cornblatt, B A; Brucato, G; Walsh, B; Elkin, K A; Brodey, I S

    2018-01-18

    Machine learning techniques were used to identify highly informative early psychosis self-report items and to validate an early psychosis screener (EPS) against the Structured Interview for Psychosis-risk Syndromes (SIPS). The Prodromal Questionnaire-Brief Version (PQ-B) and 148 additional items were administered to 229 individuals being screened with the SIPS at 7 North American Prodrome Longitudinal Study sites and at Columbia University. Fifty individuals were found to have SIPS scores of 0, 1, or 2, making them clinically low risk (CLR) controls; 144 were classified as clinically high risk (CHR) (SIPS 3-5) and 35 were found to have first episode psychosis (FEP) (SIPS 6). Spectral clustering analysis, performed on 124 of the items, yielded two cohesive item groups, the first mostly related to psychosis and mania, the second mostly related to depression, anxiety, and social and general work/school functioning. Items within each group were sorted according to their usefulness in distinguishing between CLR and CHR individuals using the Minimum Redundancy Maximum Relevance procedure. A receiver operating characteristic area under the curve (AUC) analysis indicated that maximal differentiation of CLR and CHR participants was achieved with a 26-item solution (AUC=0.899±0.001). The EPS-26 outperformed the PQ-B (AUC=0.834±0.001). For screening purposes, the self-report EPS-26 appeared to differentiate individuals who are either CLR or CHR approximately as well as the clinician-administered SIPS. The EPS-26 may prove useful as a self-report screener and may lead to a decrease in the duration of untreated psychosis. A validation of the EPS-26 against actual conversion is underway. Copyright © 2017 Elsevier B.V. All rights reserved.

  2. Approach to stress tests in SIP environment based on marginal analysis

    OpenAIRE

    Voznak, Miroslav; Rozhon, Jan

    2013-01-01

    In the field of performance metrics and measurements of SIP (Session Initiation Protocol) Proxy and B2BUA (Back-to-Back User Agent) no standardized methodology has been presented yet. This gap results in a problematic determination of a hardware, the performance of which would be cost-effective and sufficient for the running the SIP Server in a given environment. Today practice relies on the administrator’s skills and experience with the needs of the telephony infrastructure. From this and th...

  3. A Secured Load Mitigation and Distribution Scheme for Securing SIP Server

    Directory of Open Access Journals (Sweden)

    Vennila Ganesan

    2017-01-01

    Full Text Available Managing the performance of the Session Initiation Protocol (SIP server under heavy load conditions is a critical task in a Voice over Internet Protocol (VoIP network. In this paper, a two-tier model is proposed for the security, load mitigation, and distribution issues of the SIP server. In the first tier, the proposed handler segregates and drops the malicious traffic. The second tier provides a uniform load of distribution, using the least session termination time (LSTT algorithm. Besides, the mean session termination time is minimized by reducing the waiting time of the SIP messages. Efficiency of the LSTT algorithm is evaluated through the experimental test bed by considering with and without a handler. The experimental results establish that the proposed two-tier model improves the throughput and the CPU utilization. It also reduces the response time and error rate while preserving the quality of multimedia session delivery. This two-tier model provides robust security, dynamic load distribution, appropriate server selection, and session synchronization.

  4. SIP Shear Walls: Cyclic Performance of High-Aspect-Ratio Segments and Perforated Walls

    Science.gov (United States)

    Vladimir Kochkin; Douglas R. Rammer; Kevin Kauffman; Thomas Wiliamson; Robert J. Ross

    2015-01-01

    Increasing stringency of energy codes and the growing market demand for more energy efficient buildings gives structural insulated panel (SIP) construction an opportunity to increase its use in commercial and residential buildings. However, shear wall aspect ratio limitations and lack of knowledge on how to design SIPs with window and door openings are barriers to the...

  5. Sipping machine control system new design to perform integrity of nuclear fuel test in Cofrentes power plant

    Energy Technology Data Exchange (ETDEWEB)

    Palomo, M., E-mail: mpalomo@iqn.upv.es [Departamento de Ingenieria Quimica y Nuclear. Universidad Politecnica de Valencia (Spain); Urrea, M., E-mail: Matias.urrea@iberdrola.es [C.N.Cofrentes - Iberdrola Generacion S.A., Cofrentes, Valencia (Spain); Curiel, M., E-mail: m.curiel@lainsa.com [LAINSA Grupo Dominguis, Valencia (Spain); Arnaldos, A., E-mail: a.arnaldos@titaniast.com [TITANIA Servicios Tecnologicos SL, Grupo Dominguis, Valencia (Spain)

    2011-07-01

    This paper we present is related to SIPPING machine control system new design to perform integrity of nuclear fuel test. This test is a non destructive technique used for evaluating the radiated nuclear fuel coating structural integrity. It is based on the radioactive emission detection of fission elements in the reactor cooling system, using the fuel inspection equipment (SIPPING). SIPPING equipment consists of one simultaneous test bell-shaped vessel of eight fuel elements, and another one for individual element test, a control workstation and some accessories (cables, thermocouples, hoses). SIPPING inspection is carried out by means of fuel element vessel. Through air injection, water flows around the element and heat evacuation is reduced, so fuel elements temperature increases. Those elements with faults shall expelled fission components dissolved in water and/or as a gas component. The project aim is the SIPPING system control design and software based on LabVIEW, for control, monitoring and documentation of the SIPPING Test. This project shall give a major functionality to the system and, at the same time, shall facilitate the user a friendlier and interactive environment allowing: to substitute the present work platform with a real-time electronic system based on cRIO and a control software ad-hoc designed for SIPPING system; to equip new system of a major redundancy for data storage, minimising loss probability of the same. (author)

  6. Calculation of fuel element temperature TRIGA 2000 reactor in sipping test tubes using CFD

    International Nuclear Information System (INIS)

    Sudjatmi KA

    2013-01-01

    It has been calculated the fuel element temperature in the sipping test of Bandung TRIGA 2000 reactor. The calculation needs to be done to ascertain that the fuel element temperatures are below or at the limit of the allowable temperature fuel elements during reactor operation. ensuring that the implementation of the test by using this device, the temperature is still within safety limits. The calculation is done by making a model sipping test tubes containing a fuel element surrounded by 9 fuel elements. according to the position sipping test tubes in the reactor core. by using Gambit. Dimensional model adapted to the dimensions of the tube and the fuel element in the reactor core of Bandung TRIGA 2000 reactor. Sipping test Operation for each fuel element performed for 30 minutes at 300 kW power. Calculations were performed using CFD software and as input adjusted parameters of TRIGA 2000 reactor. Simulations carried out on the operation of the 30, 60, 90, 120, 150, 180 and 210 minutes. The calculation result shows that the temperature of the fuel in tubes sipping test of 236.06 °C, while the temperature of the wall is 87.58 °C. The maximum temperature in the fuel center of TRIGA 2000 reactor in normal operation is 650 °C. and the boiling is not allowed in the reactor. So it can be concluded that the operation of the sipping test device are is very safe because the fuel center temperature is below the temperature limits the allowable fuel under normal operating conditions as well as the fuel element wall temperature is below the boiling temperature of water. (author)

  7. The Social Interaction Phobia Scale: Continued support for the psychometric validity of the SIPS using clinical and non-clinical samples.

    Science.gov (United States)

    Menatti, Alison R; Weeks, Justin W; Carleton, R Nicholas; Morrison, Amanda S; Heimberg, Richard G; Hope, Debra A; Blanco, Carlos; Schneier, Franklin R; Liebowitz, Michael R

    2015-05-01

    The present study sought to extend findings supporting the psychometric validity of a promising measure of social anxiety (SA) symptoms, the Social Interaction Phobia Scale (SIPS; Carleton et al., 2009). Analyses were conducted using three samples: social anxiety disorder (SAD) patients, generalized anxiety disorder (GAD) patients, and healthy controls. SIPS scores of SAD patients demonstrated internal consistency and construct validity, and the previously demonstrated three-factor structure of the SIPS was replicated. Further, the SIPS total score uniquely predicted SA symptoms, and SIPS scores were significantly higher for SAD patients than GAD patients or controls. Two cut-off scores that discriminated SAD patients from GAD patients and from healthy controls were identified. The current study is the first to replicate the SIPS three-factor model in a large, treatment-seeking sample of SAD patients and establish a cut-off score discriminating SAD from GAD patients. Findings support the SIPS as a valid, SAD-specific assessment instrument. Copyright © 2015 Elsevier Ltd. All rights reserved.

  8. Energy Efficiency and Renewable Energy in SIPs and TIPs

    Science.gov (United States)

    Tools and guides to encourage state, tribal and local agencies to consider incorporating Energy Efficiency (EE) and Renewable Energy (RE) policies and programs in their State and Tribal Implementation Plans (SIPs/TIPs).

  9. 76 FR 28437 - Disease, Disability, and Injury Prevention and Control Special Interest Project (SIP): Initial...

    Science.gov (United States)

    2011-05-17

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and Control Special Interest Project (SIP): Initial Review The meeting... Disease or Treated by Assisted Reproductive Technology, SIP11-048, Panel F,'' initial review In accordance...

  10. JACoW SIP4C/C++ at CERN - Status and lessons learned

    CERN Document Server

    Jensen, Steen; Dworak, Andrzej; Gourber-Pace, Marine; Hoguin, Frederic; Lauener, Joel; Locci, Frank; Sigerud, Katarina; Sliwinski, Wojciech

    2018-01-01

    After 4 years of promoting the Software Improvement Process for C/C++ (SIP4C/C++) initiative at CERN, we describe the current status for tools and procedures along with how they have been integrated into our environment. Based on feedback from four project teams, we present reasons for and against their adoption. Finally, we show how SIP4C/C++ has improved development and delivery processes as well as the first-line support of delivered products.

  11. Design of SIP transformation server for efficient media negotiation

    Science.gov (United States)

    Pack, Sangheon; Paik, Eun Kyoung; Choi, Yanghee

    2001-07-01

    Voice over IP (VoIP) is one of the advanced services supported by the next generation mobile communication. VoIP should support various media formats and terminals existing together. This heterogeneous environment may prevent diverse users from establishing VoIP sessions among them. To solve the problem an efficient media negotiation mechanism is required. In this paper, we propose the efficient media negotiation architecture using the transformation server and the Intelligent Location Server (ILS). The transformation server is an extended Session Initiation Protocol (SIP) proxy server. It can modify an unacceptable session INVITE message into an acceptable one using the ILS. The ILS is a directory server based on the Lightweight Directory Access Protocol (LDAP) that keeps userí*s location information and available media information. The proposed architecture can eliminate an unnecessary response and re-INVITE messages of the standard SIP architecture. It takes only 1.5 round trip times to negotiate two different media types while the standard media negotiation mechanism takes 2.5 round trip times. The extra processing time in message handling is negligible in comparison to the reduced round trip time. The experimental results show that the session setup time in the proposed architecture is less than the setup time in the standard SIP. These results verify that the proposed media negotiation mechanism is more efficient in solving diversity problems.

  12. Scilab and SIP for Image Processing

    OpenAIRE

    Fabbri, Ricardo; Bruno, Odemir Martinez; Costa, Luciano da Fontoura

    2012-01-01

    This paper is an overview of Image Processing and Analysis using Scilab, a free prototyping environment for numerical calculations similar to Matlab. We demonstrate the capabilities of SIP -- the Scilab Image Processing Toolbox -- which extends Scilab with many functions to read and write images in over 100 major file formats, including PNG, JPEG, BMP, and TIFF. It also provides routines for image filtering, edge detection, blurring, segmentation, shape analysis, and image recognition. Basic ...

  13. A new technique to modify hypereutectic Al-24%Si alloys by a Si-P master alloy

    Energy Technology Data Exchange (ETDEWEB)

    Wu Yaping; Wang Shujun; Li Hui [Key Laboratory of Liquid Structure and Heredity of Materials, Ministry of Education, Shandong University, 73 Jingshi Road, Jinan 250061 (China); Liu Xiangfa [Key Laboratory of Liquid Structure and Heredity of Materials, Ministry of Education, Shandong University, 73 Jingshi Road, Jinan 250061 (China)], E-mail: xfliu@sdu.edu.cn

    2009-05-27

    The modification effect of a Si-P master alloy on Al-24%Si alloy was investigated by using electron probe micro-analyzer (EPMA) and optical microscopy (OM). The dissolution problem of the Si-P master alloys was solved by changing the sequence of addition. When the Si-P master alloy was added into Al melt before the addition of silicon, the best modification effect could be achieved. The modification parameters of the master alloy on Al-24%Si alloy were optimized through designing and analyzing the orthogonal experiment, and their influences on the modification effect were discussed. The results show that the influence of temperature on the modification effect is the greatest, followed by the addition level, and the holding time is the least. The optimized modification parameters are the modification temperature of 810 deg. C, the addition level of 0.35 wt.%, the holding time of 30 min + 50 min whose meaning is that the Si-P master alloy is added firstly to the molten Al, and silicon is added 30 min later, then holding another 50 min. In addition, the modification mechanism of the Si-P master alloy on Al-24%Si alloy was also discussed.

  14. Louisiana SIP: LAC 33:III Ch 2147. Limiting Volatile Organic Compound (VOC) Emissions from Reactor Processes and Distillation Operations in Synthetic Organic Chemical manufacturing Industry (SOCMI); SIP effective 2011-08-04 (LAd34) to 2017-09-27

    Science.gov (United States)

    Louisiana SIP: LAC 33:III Ch 2147. Limiting Volatile Organic Compound (VOC) Emissions from Reactor Processes and Distillation Operations in Synthetic Organic Chemical manufacturing Industry (SOCMI); SIP effective 2011-08-04 (LAd34) to 2017-09-27

  15. 77 FR 31358 - Disease, Disability, and Injury Prevention and Control Special Interest Projects (SIPs): Initial...

    Science.gov (United States)

    2012-05-25

    ... announced below concerns Research to Enhance Community- Based Fall Prevention among Older Adults, SIP12-058, and Developing a Compendium of Measures and Questions to Assess Mobility: A Focus on Older Adult... Older Adults, SIP12-058, and Developing a Compendium of Measures and Questions to Assess Mobility: A...

  16. Study on the essential variables for pipe outer surface irradiated laser stress improvement process (L-SIP). Development of pipe outer surface irradiated laser stress improvement process (L-SIP)

    International Nuclear Information System (INIS)

    Ohta, Takahiro; Kamo, Kazuhiko; Muroya, Itaru; Asada, Seiji; Nakamura, Yasuo

    2009-01-01

    The new process called L-SIP (outer surface irradiated Laser Stress Improvement Process) is developed to improve the tensile residual stress of the inner surface near the butt welded joints of pipes in the compression stress. The temperature gradient occurs in the thickness of pipes in heating the outer surface rapidly by laser beam. By the thermal expansion difference between the inner surface and the outer surface, the compression stress occurs near the inner surface of pipes. In this paper, the essential variables for L-SIP is studied by experimental and FEM analysis. The range of the essential variables for L-SIP, which are defined by thermo-elastic FEM analysis, are Tmax=550 - 650degC, L Q /√rh ≥ 3, W Q /√rh ≥ 1.7, and, 0.04 ≤ F 0 ≤ 0.10 where Tmax is maximum temperature on the monitor point of the outer surface, F 0 is k x τ 0 /h 2 , k is thermal diffusivity coefficient, τ 0 is the temperature rise time from 100degC to maximum temperature on the monitor point of the outer surface, W Q is τ 0 x v, υ is moving velocity, L Q is the uniform temperature length in the axial direction, h is thickness of the pipe, and r is average radius of the pipe. It is showed by thermo-elastic-plastic FEM analysis that the residual stresses near the inner surface of pipes are improved in 4 different size pipes under the same essential variables. L-SIP is actually applied to welding joints of 4B x Sch160 and 2B x Sch80 SUS304 type stainless steel pipes within the defined range of the essential variables. The measured welding residual stresses on the inner surface near the welding joints are tensile. The residual stresses on the inner surface change to compression in all joints by L-SIP. (author)

  17. Analysis of Active Methylotrophic Communities: When DNA-SIP Meets High-Throughput Technologies.

    Science.gov (United States)

    Taubert, Martin; Grob, Carolina; Howat, Alexandra M; Burns, Oliver J; Chen, Yin; Neufeld, Josh D; Murrell, J Colin

    2016-01-01

    Methylotrophs are microorganisms ubiquitous in the environment that can metabolize one-carbon (C1) compounds as carbon and/or energy sources. The activity of these prokaryotes impacts biogeochemical cycles within their respective habitats and can determine whether these habitats act as sources or sinks of C1 compounds. Due to the high importance of C1 compounds, not only in biogeochemical cycles, but also for climatic processes, it is vital to understand the contributions of these microorganisms to carbon cycling in different environments. One of the most challenging questions when investigating methylotrophs, but also in environmental microbiology in general, is which species contribute to the environmental processes of interest, or "who does what, where and when?" Metabolic labeling with C1 compounds substituted with (13)C, a technique called stable isotope probing, is a key method to trace carbon fluxes within methylotrophic communities. The incorporation of (13)C into the biomass of active methylotrophs leads to an increase in the molecular mass of their biomolecules. For DNA-based stable isotope probing (DNA-SIP), labeled and unlabeled DNA is separated by isopycnic ultracentrifugation. The ability to specifically analyze DNA of active methylotrophs from a complex background community by high-throughput sequencing techniques, i.e. targeted metagenomics, is the hallmark strength of DNA-SIP for elucidating ecosystem functioning, and a protocol is detailed in this chapter.

  18. Generation of a gene cassette for genetically engineered Salmonella Enteritidis in the specific region of the sipC gene

    Directory of Open Access Journals (Sweden)

    M Ghasemi

    2017-05-01

    Full Text Available Introduction: Salmonellosis is an infection caused by eating contaminated food with Salmonella, and it can occur in humans and other animals. Salmonella has acquired the ability to create the infection due to the presence of several virulence genes. One of the virulence genes of salmonella is sipC gene that coding the SipC protein. The aim of this study was creating the gene cassette to genetically engineered Salmonella enteritidis in the specific region of the sipC gene. Methods: In this study, after DNA extraction from Salmonella, the upstream and downstream regions of the sipC gene was amplified based on PCR method. The PCR products were cloned with T/A cloning method and they were inserted into the pGEM vector. In order to generate the final gene cassette, each of the upstream and downstream regions of the sipC gene was subcloned into the pET32 vector, and cloning accuracy was assessed by PCR and enzyme digestion methods. Results: Amplification of the 320 bp upstream and 206 bp downstream of sipC gene was successful by PCR method. T/A cloning of these fragments were caused the formation of two pGEM-up and pGEM-down recombinant vectors. Results that were confirmed the sub-cloning accuracy indicate the formation of the final pET32-up-down gene cassette. Conclusion: The generated gene cassette in this study was considered as a multi-purpose cassette that is able to specific gene manipulation of Salmonella sipC gene by homologous recombination matched. This gene cassette has the necessary potential for sipC gene deletion or insertion of any useful gene instead of sipC gene.

  19. Sipping machine control system new design to perform integrity of nuclear fuel test in Cofrentes power plant

    Energy Technology Data Exchange (ETDEWEB)

    Curiel, M. [Logistica y Acondicionamientos Industriales SAU, Sorolla Center, local 10, Av. de las Cortes Valencianas No. 58, 46015 Valencia (Spain); Palomo, M. J. [ISIRYM, Universidad Politecnica de Valencia, Camino de Vera s/n, Valencia (Spain); Urrea, M. [Iberdrola Generacion S. A., Central Nuclear Cofrentes, Carretera Almansa Requena s/n, 04662 Cofrentes, Valencia (Spain); Vaquer, J., E-mail: m.curiel@lainsa.co [TITANIA Servicios Tecnologicos SL, Sorolla Center, local 10, Av. de las Cortes Valencianas No. 58, 46015 Valencia (Spain)

    2010-10-15

    This paper related to Sipping machine control system new design to perform integrity of nuclear fuel test. This test is a non destructive technique used for evaluating the radiated nuclear fuel coating structural integrity. It is based on the radioactive emission detection of fission elements in the reactor cooling system, using the fuel inspection equipment Sipping. The equipment consists of one simultaneous test bell-shaped vessel of eight fuel elements, and another one for individual element test, a control workstation and some accessories (cables, thermocouples, hoses). Sipping inspection is carried out by means of fuel element vessel. Through air injection, water flows around the element and heat evacuation is reduced, so fuel elements temperature increases. Those elements with faults shall expelled fission components dissolved in water and/or as a gas component. The project aim is the Sipping system control design and software based on LabVIEWTM, for control, monitoring and documentation of the Sipping test. This project shall give a major functionality to the system and, at the same time, shall facilitate the user a friendlier and interactive environment allowing: 1) To substitute the present work platform with a real-time electronic system based on cRIO and a control software ad-hoc designed for Sipping system. 2) To equip new system of a major redundancy for data storage, minimising loss probability of the same. (Author)

  20. Towards a Standard Psychometric Diagnostic Interview for Subjects at Ultra High Risk of Psychosis: CAARMS versus SIPS

    Science.gov (United States)

    Fusar-Poli, P.; Cappucciati, M.; Rutigliano, G.; Lee, T. Y.; Beverly, Q.; Bonoldi, I.; Lelli, J.; Kaar, S. J.; Gago, E.; Rocchetti, M.; Patel, R.; Bhavsar, V.; Tognin, S.; Badger, S.; Calem, M.; Lim, K.; Kwon, J. S.; Perez, J.; McGuire, P.

    2016-01-01

    Background. Several psychometric instruments are available for the diagnostic interview of subjects at ultra high risk (UHR) of psychosis. Their diagnostic comparability is unknown. Methods. All referrals to the OASIS (London) or CAMEO (Cambridgeshire) UHR services from May 13 to Dec 14 were interviewed for a UHR state using both the CAARMS 12/2006 and the SIPS 5.0. Percent overall agreement, kappa, the McNemar-Bowker χ 2 test, equipercentile methods, and residual analyses were used to investigate diagnostic outcomes and symptoms severity or frequency. A conversion algorithm (CONVERT) was validated in an independent UHR sample from the Seoul Youth Clinic (Seoul). Results. There was overall substantial CAARMS-versus-SIPS agreement in the identification of UHR subjects (n = 212, percent overall agreement = 86%; kappa = 0.781, 95% CI from 0.684 to 0.878; McNemar-Bowker test = 0.069), with the exception of the brief limited intermittent psychotic symptoms (BLIPS) subgroup. Equipercentile-linking table linked symptoms severity and frequency across the CAARMS and SIPS. The conversion algorithm was validated in 93 UHR subjects, showing excellent diagnostic accuracy (CAARMS to SIPS: ROC area 0.929; SIPS to CAARMS: ROC area 0.903). Conclusions. This study provides initial comparability data between CAARMS and SIPS and will inform ongoing multicentre studies and clinical guidelines for the UHR psychometric diagnostic interview. PMID:27314005

  1. Towards a Standard Psychometric Diagnostic Interview for Subjects at Ultra High Risk of Psychosis: CAARMS versus SIPS

    Directory of Open Access Journals (Sweden)

    P. Fusar-Poli

    2016-01-01

    Full Text Available Background. Several psychometric instruments are available for the diagnostic interview of subjects at ultra high risk (UHR of psychosis. Their diagnostic comparability is unknown. Methods. All referrals to the OASIS (London or CAMEO (Cambridgeshire UHR services from May 13 to Dec 14 were interviewed for a UHR state using both the CAARMS 12/2006 and the SIPS 5.0. Percent overall agreement, kappa, the McNemar-Bowker χ2 test, equipercentile methods, and residual analyses were used to investigate diagnostic outcomes and symptoms severity or frequency. A conversion algorithm (CONVERT was validated in an independent UHR sample from the Seoul Youth Clinic (Seoul. Results. There was overall substantial CAARMS-versus-SIPS agreement in the identification of UHR subjects (n=212, percent overall agreement = 86%; kappa = 0.781, 95% CI from 0.684 to 0.878; McNemar-Bowker test = 0.069, with the exception of the brief limited intermittent psychotic symptoms (BLIPS subgroup. Equipercentile-linking table linked symptoms severity and frequency across the CAARMS and SIPS. The conversion algorithm was validated in 93 UHR subjects, showing excellent diagnostic accuracy (CAARMS to SIPS: ROC area 0.929; SIPS to CAARMS: ROC area 0.903. Conclusions. This study provides initial comparability data between CAARMS and SIPS and will inform ongoing multicentre studies and clinical guidelines for the UHR psychometric diagnostic interview.

  2. Sipping machine control system new design to perform integrity of nuclear fuel test in Cofrentes power plant

    International Nuclear Information System (INIS)

    Curiel, M.; Palomo, M. J.; Urrea, M.; Vaquer, J.

    2010-10-01

    This paper related to Sipping machine control system new design to perform integrity of nuclear fuel test. This test is a non destructive technique used for evaluating the radiated nuclear fuel coating structural integrity. It is based on the radioactive emission detection of fission elements in the reactor cooling system, using the fuel inspection equipment Sipping. The equipment consists of one simultaneous test bell-shaped vessel of eight fuel elements, and another one for individual element test, a control workstation and some accessories (cables, thermocouples, hoses). Sipping inspection is carried out by means of fuel element vessel. Through air injection, water flows around the element and heat evacuation is reduced, so fuel elements temperature increases. Those elements with faults shall expelled fission components dissolved in water and/or as a gas component. The project aim is the Sipping system control design and software based on LabVIEWTM, for control, monitoring and documentation of the Sipping test. This project shall give a major functionality to the system and, at the same time, shall facilitate the user a friendlier and interactive environment allowing: 1) To substitute the present work platform with a real-time electronic system based on cRIO and a control software ad-hoc designed for Sipping system. 2) To equip new system of a major redundancy for data storage, minimising loss probability of the same. (Author)

  3. 40 CFR 51.125 - Emissions reporting requirements for SIP revisions relating to budgets for SO2 and NOX emissions.

    Science.gov (United States)

    2010-07-01

    ... SIP revisions relating to budgets for SO2 and NOX emissions. 51.125 Section 51.125 Protection of... SIP revisions relating to budgets for SO2 and NOX emissions. (a) For its transport SIP revision under § 51.123 and/or 51.124, each State must submit to EPA SO2 and/or NOX emissions data as described in...

  4. Louisiana SIP: LAC 33:III Ch 21 Subchap J, 2147--Limiting Volatile Organic Compound (VOC) Emissions from Reactor Processes and Distillation Operations in Synthetic Organic Chemical manufacturing Industry (SOCMI); SIP effective 1998-02-02 (LAc74) to more..

    Science.gov (United States)

    Louisiana SIP: LAC 33:III Ch 21 Subchap J, 2147--Limiting Volatile Organic Compound (VOC) Emissions from Reactor Processes and Distillation Operations in Synthetic Organic Chemical manufacturing Industry (SOCMI); SIP effective 1998-02-02 (LAc74) more...

  5. Spectral Induced Polarization (SIP) monitoring during Microbial Enhanced Oil Recovery (MEOR)

    Science.gov (United States)

    Heenan, J. W.; Ntarlagiannis, D.; Slater, L. D.

    2010-12-01

    Jeffrey Heenan, Dimitrios Ntarlagiannis, Lee Slater Department of Earth and Environmental Sciences, Rutgers University, Newark NJ Microbial Enhanced Oil Recovery (MEOR) is an established, cost effective, method for enhancing tertiary oil recovery. Although not commonly used for shallow heavy oils, it could be a viable alternative since it can offer sustainable economic recovery and minimal environmental impact. A critical component of successful MEOR treatments is accurate, real time monitoring of the biodegradation processes resulting from the injection of microbial communities into the formation; results of recent biogeophysical research suggest that minimally-invasive geophysical methods could significantly contribute to such monitoring efforts. Here we present results of laboratory experiments, to assess the sensitivity of the spectral induced polarization method (SIP) to MEOR treatments. We used heavy oil, obtained from a shallow oilfield in SW Missouri, to saturate three sand columns. We then followed common industry procedures,and used a commercially available microbial consortia, to treat the oil columns. The active MEOR experiments were performed in duplicate while a control column maintained similar conditions, without promoting microbial activity and oil degradation. We monitored the SIP signatures, between 0.001 Hz and 1000 Hz, for a period of six months. To support the geophysical measurements we also monitored common geochemical parameters, including pH, Eh and fluid conductivity, and collected weekly fluid samples from the outflow and inflow for further analysis; fluid samples were analyzed to confirm that microbes actively degraded the heavy oils in the column while destructive analysis of the solid materials was performed upon termination of the experiment. Preliminary analysis of the results suggests that SIP is sensitive to MEOR processes. In both inoculated columns we recorded an increase in the low frequency polarization with time; measureable

  6. The small serine-threonine protein SIP2 interacts with STE12 and is involved in ascospore germination in Sordaria macrospora.

    Science.gov (United States)

    Elleuche, Skander; Bernhards, Yasmine; Schäfers, Christian; Varghese, Jans Manjali; Nolting, Nicole; Pöggeler, Stefanie

    2010-12-01

    In fungi, the homoeodomain protein STE12 controls diverse developmental processes, and derives its regulatory specificity from different protein interactions. We recently showed that in the homothallic ascomycete Sordaria macrospora, STE12 is essential for ascospore development, and is able to interact with the alpha-domain mating-type protein SMTA-1 and the MADS box protein MCM1. To further evaluate the functional roles of STE12, we used the yeast two-hybrid approach to identify new STE12-interacting partners. Using STE12 as bait, a small, serine-threonine-rich protein (designated STE12-interacting protein 2, SIP2) was identified. SIP2 is conserved among members of the fungal class Sordariomycetes. In vivo localization studies revealed that SIP2 was targeted to the nucleus and cytoplasm. The STE12/SIP2 interaction was further confirmed in vivo by bimolecular fluorescence complementation. Nuclear localization of SIP2 was apparently mediated by STE12. Unlike deletion of ste12, deletion of sip2 in S. macrospora led to only a slight decrease in ascospore germination, and no other obvious morphological phenotype. In comparison to the Δste12 single knockout strain, ascospore germination was significantly increased in a Δsip2/ste12 double knockout strain. Our data provide evidence for a regulatory role of the novel fungal protein SIP2 in ascospore germination. Copyright © 2010 Elsevier GmbH. All rights reserved.

  7. Stereotactic body radiotherapy (SBRT) in recurrent or oligometastatic pancreatic cancer. A toxicity review of simultaneous integrated protection (SIP) versus conventional SBRT

    Energy Technology Data Exchange (ETDEWEB)

    Gkika, E.; Kirste, S.; Schimek-Jasch, T. [University Medical Center Freiburg, Department of Radiation Oncology, Freiburg im Breisgau (Germany); Adebahr, S. [University Medical Center Freiburg, Department of Radiation Oncology, Freiburg im Breisgau (Germany); German Cancer Consortium (DKTK), Heidelberg (partner site Freiburg) (Germany); Wiehle, R. [University Medical Center Freiburg, Division of Medical Physics, Department of Radiation Oncology, Freiburg (Germany); Claus, R. [University Medical Center Freiburg, Department of Hematology, Oncology and Stem-Cell Transplantation, Freiburg (Germany); Wittel, U. [University Medical Center Freiburg, Department of General and Visceral Surgery, Freiburg (Germany); Nestle, U.; Grosu, A.L.; Brunner, T.B. [University Medical Center Freiburg, Department of Radiation Oncology, Freiburg im Breisgau (Germany); German Cancer Consortium (DKTK), Heidelberg (partner site Freiburg) (Germany); University of Freiburg, Faculty of Medicine, Freiburg (Germany); Baltas, D. [University Medical Center Freiburg, Division of Medical Physics, Department of Radiation Oncology, Freiburg (Germany); German Cancer Consortium (DKTK), Heidelberg (partner site Freiburg) (Germany); University of Freiburg, Faculty of Medicine, Freiburg (Germany)

    2017-06-15

    Stereotactic body radiotherapy (SBRT) in pancreatic cancer can be limited by its proximity to organs at risk (OAR). In this analysis, we evaluated the toxicity and efficacy of two different treatment approaches in patients with locally recurrent or oligometastatic pancreatic cancer. According to the prescription method, patients were divided in two cohorts (C1 and C2). The planning target volume (PTV) was created through a 4 mm expansion of the internal target volume. In C2, a subvolume was additionally created, a simultaneous integrated protection (SIP), which is the overlap of the PTV with the planning risk volume of an OAR to which we prescribed a reduced dose. In all, 18 patients were treated (7 with local recurrences, 9 for oligometastases, 2 for both). Twelve of 23 lesions were treated without SIP (C1) and 11 with SIP (C2). The median follow-up was 12.8 months. Median overall survival (OS) was 13.2 (95% confidence interval [CI] 9.8-14.6) months. The OS rates at 6 and 12 months were 87 and 58%, respectively. Freedom from local progression for combined cohorts at 6 and 12 months was 93 and 67% (95% CI 15-36), respectively. Local control was not statistically different between the two groups. One patient in C2 experienced grade ≥3 acute toxicities and 1 patient in C1 experienced a grade ≥3 late toxicity. The SIP approach is a useful prescription method for abdominal SBRT with a favorable toxicity profile which does not compromise local control and overall survival despite dose sacrifices in small subvolumes. (orig.) [German] Die stereotaktische Strahlentherapie (SBRT) ist bei Pankreaskarzinomen durch die enge Lagebeziehung der Risikoorgane (OAR) zum Zielvolumen erschwert. In dieser Analyse evaluierten wir die Toxizitaet und die Lokalkontrolle von zwei unterschiedlichen Therapiestrategien bei Patienten mit rezidivierendem oder oligometastatischem Pankreaskarzinom. Die Patienten wurden anhand der Verschreibungsmethode in zwei Kohorten geteilt (C1 und C2). Das

  8. Divergent Evolution of the Transcriptional Network Controlled by Snf1-Interacting Protein Sip4 in Budding Yeasts.

    Directory of Open Access Journals (Sweden)

    Constance Mehlgarten

    Full Text Available Cellular responses to starvation are of ancient origin since nutrient limitation has always been a common challenge to the stability of living systems. Hence, signaling molecules involved in sensing or transducing information about limiting metabolites are highly conserved, whereas transcription factors and the genes they regulate have diverged. In eukaryotes the AMP-activated protein kinase (AMPK functions as a central regulator of cellular energy homeostasis. The yeast AMPK ortholog SNF1 controls the transcriptional network that counteracts carbon starvation conditions by regulating a set of transcription factors. Among those Cat8 and Sip4 have overlapping DNA-binding specificity for so-called carbon source responsive elements and induce target genes upon SNF1 activation. To analyze the evolution of the Cat8-Sip4 controlled transcriptional network we have compared the response to carbon limitation of Saccharomyces cerevisiae to that of Kluyveromyces lactis. In high glucose, S. cerevisiae displays tumor cell-like aerobic fermentation and repression of respiration (Crabtree-positive while K. lactis has a respiratory-fermentative life-style, respiration being regulated by oxygen availability (Crabtree-negative, which is typical for many yeasts and for differentiated higher cells. We demonstrate divergent evolution of the Cat8-Sip4 network and present evidence that a role of Sip4 in controlling anabolic metabolism has been lost in the Saccharomyces lineage. We find that in K. lactis, but not in S. cerevisiae, the Sip4 protein plays an essential role in C2 carbon assimilation including induction of the glyoxylate cycle and the carnitine shuttle genes. Induction of KlSIP4 gene expression by KlCat8 is essential under these growth conditions and a primary function of KlCat8. Both KlCat8 and KlSip4 are involved in the regulation of lactose metabolism in K. lactis. In chromatin-immunoprecipitation experiments we demonstrate binding of both, KlSip4 and

  9. Louisiana SIP: LAC 33:III Ch 2132. Stage II Vapor Recovery Systems for Control of Vehicle Refuelling Emissions at Gasoline Dispensing Facilities; SIP effective 2011-08-04 (LAd34) and 2016-02-29 (LAd47) to 2017-09-27

    Science.gov (United States)

    Louisiana SIP: LAC 33:III Ch 2132. Stage II Vapor Recovery Systems for Control of Vehicle Refuelling Emissions at Gasoline Dispensing Facilities; SIP effective 2011-08-04 (LAd34) and 2016-02-29 (LAd47) to 2017-09-27

  10. Covert Channels in SIP for VoIP Signalling

    Science.gov (United States)

    Mazurczyk, Wojciech; Szczypiorski, Krzysztof

    In this paper, we evaluate available steganographic techniques for SIP (Session Initiation Protocol) that can be used for creating covert channels during signaling phase of VoIP (Voice over IP) call. Apart from characterizing existing steganographic methods we provide new insights by introducing new techniques. We also estimate amount of data that can be transferred in signalling messages for typical IP telephony call.

  11. Impact of complications and bladder cancer stage on quality of life in patients with different types of urinary diversions.

    Science.gov (United States)

    Prcic, Alden; Aganovic, Damir; Hadziosmanovic, Osman

    2013-12-01

    Determine correlation between complications and stage of the disease and their impact on quality of life in patients with different types of ileal urinary derivation after radical cystectomy, and upon estimation of acquired results, to suggest the most acceptable type of urinary diversion. In five year period a prospective clinical study was performed on 106 patients, to whom a radical cystectomy was performed due to bladder cancer. Patients were divided into two groups, 66 patients with ileal conduit derivation and 40 patients with orthotopic derivation, whereby in each group a comparison between reflux and anti-reflux technique of orthotopic bladder was made. All patients from both groups filled the Sickness Impact Profile score six months after the operation. All patients had CT urography or Intravenous urography performed, as well as standard laboratory, vitamin B12 blood values, in order to evaluate early (ileus or subileus, wound dehiscence, bladder fistula, rupture of orthotopic bladder, urine extravazation) and late complications (VUR, urethral stricture, ureter stenosis, metabolic acidosis, mineral dis-balance, hypovitaminosis of vitamin B12, increased resorption of bone calcium, urinary infection, kidney damage, relapse of primary disease), so as disease stage and it's impact on quality of life. From gained results we observe that each category of SIP score correlates with different rate of correlation with the type of operation, group, T, N, and R grade, except work category. Average value of SIP score rises depending on the type of operation and T stage. It is notable that there is no difference in T1 stage, no matter the type of operation. So the average value of SIP score in T1 stage for conduit was 20.3, for Abol-Enein and Ghoneim 17.25 and Hautmann 18.75 respectively. Average value of SIP score in T2 stage for conduit was 31, for Abol-Enein and Ghoneim 19.1 and Hautmann 17.8. Average value of SIP score in T3 stage for conduit was 38.03, for Abol

  12. Cooperation of technical support organizations of state nuclear regulatory committee of Ukraine in sip safety regulation

    International Nuclear Information System (INIS)

    Bikov, V.O.; Kyilochits'ka, T.P.; Bogorins'kij, P.; Vasil'chenko, V.M.; Kondrat'jev, S.M.; Smishlyajeva, S.P.; Troter, D.

    2002-01-01

    The main task of the technical support in the Shelter Implementation Plan (SIP) licensing process consists in Technical Evaluation of SIP projects and documents submitted by the Licensee to State Nuclear Regulatory Committee to substantiate the safety of Shelter-related work. The goal of this task is to evaluate the submitted materials whether they meet the requirements of nuclear and radiation safety

  13. Development and implementation of the Caribbean Laboratory Quality Management Systems Stepwise Improvement Process (LQMS-SIP) Towards Accreditation.

    Science.gov (United States)

    Alemnji, George; Edghill, Lisa; Guevara, Giselle; Wallace-Sankarsingh, Sacha; Albalak, Rachel; Cognat, Sebastien; Nkengasong, John; Gabastou, Jean-Marc

    2017-01-01

    Implementing quality management systems and accrediting laboratories in the Caribbean has been a challenge. We report the development of a stepwise process for quality systems improvement in the Caribbean Region. The Caribbean Laboratory Stakeholders met under a joint Pan American Health Organization/US Centers for Disease Control and Prevention initiative and developed a user-friendly framework called 'Laboratory Quality Management System - Stepwise Improvement Process (LQMS-SIP) Towards Accreditation' to support countries in strengthening laboratory services through a stepwise approach toward fulfilling the ISO 15189: 2012 requirements. This approach consists of a three-tiered framework. Tier 1 represents the minimum requirements corresponding to the mandatory criteria for obtaining a licence from the Ministry of Health of the participating country. The next two tiers are quality improvement milestones that are achieved through the implementation of specific quality management system requirements. Laboratories that meet the requirements of the three tiers will be encouraged to apply for accreditation. The Caribbean Regional Organisation for Standards and Quality hosts the LQMS-SIP Secretariat and will work with countries, including the Ministry of Health and stakeholders, including laboratory staff, to coordinate and implement LQMS-SIP activities. The Caribbean Public Health Agency will coordinate and advocate for the LQMS-SIP implementation. This article presents the Caribbean LQMS-SIP framework and describes how it will be implemented among various countries in the region to achieve quality improvement.

  14. The role of groundwater discharge fluxes on Si:P ratios in a major tributary to Lake Erie.

    Science.gov (United States)

    Maavara, Taylor; Slowinski, Stephanie; Rezanezhad, Fereidoun; Van Meter, Kimberly; Van Cappellen, Philippe

    2018-05-01

    Groundwater discharge can be a major source of nutrients to river systems. Although quantification of groundwater nitrate loading to streams is common, the dependence of surface water silicon (Si) and phosphorus (P) concentrations on groundwater sources has rarely been determined. Additionally, the ability of groundwater discharge to drive surface water Si:P ratios has not been contextualized relative to riverine inputs or in-stream transformations. In this study, we quantify the seasonal dynamics of Si and P cycles in the Grand River (GR) watershed, the largest Canadian watershed draining into Lake Erie, to test our hypothesis that regions of Si-rich groundwater discharge increase surface water Si:P ratios. Historically, both the GR and Lake Erie have been considered stoichiometrically P-limited, where the molar Si:P ratio is greater than the ~16:1 phytoplankton uptake ratio. However, recent trends suggest that eastern Lake Erie may be approaching Si-limitation. We sampled groundwater and surface water for dissolved and reactive particulate Si as well as total dissolved P for 12months within and downstream of a 50-km reach of high groundwater discharge. Our results indicate that groundwater Si:P ratios are lower than the corresponding surface water and that groundwater is a significant source of bioavailable P to surface water. Despite these observations, the watershed remains P-limited for the majority of the year, with localized periods of Si-limitation. We further find that groundwater Si:P ratios are a relatively minor driver of surface water Si:P, but that the magnitude of Si and P loads from groundwater represent a large proportion of the overall fluxes to Lake Erie. Copyright © 2017 Elsevier B.V. All rights reserved.

  15. A single sip of a strong alcoholic beverage causes exposure to carcinogenic concentrations of acetaldehyde in the oral cavity.

    Science.gov (United States)

    Linderborg, Klas; Salaspuro, Mikko; Väkeväinen, Satu

    2011-09-01

    The aim of this study was to explore oral exposure to carcinogenic (group 1) acetaldehyde after single sips of strong alcoholic beverages containing no or high concentrations of acetaldehyde. Eight volunteers tasted 5 ml of ethanol diluted to 40 vol.% with no acetaldehyde and 40 vol.% calvados containing 2400 μM acetaldehyde. Salivary acetaldehyde and ethanol concentrations were measured by gas chromatography. The protocol was repeated after ingestion of ethanol (0.5 g/kg body weight). Salivary acetaldehyde concentration was significantly higher after sipping calvados than after sipping ethanol at 30s both with (215 vs. 128 μmol/l, psipping of the alcoholic beverages. Carcinogenic concentrations of acetaldehyde are produced from ethanol in the oral cavity instantly after a small sip of strong alcoholic beverage, and the exposure continues for at least 10 min. Acetaldehyde present in the beverage has a short-term effect on total acetaldehyde exposure. Copyright © 2011 Elsevier Ltd. All rights reserved.

  16. Telescope sipping the optimum fuel leak detection system

    International Nuclear Information System (INIS)

    Deleryd, R.

    1998-01-01

    The TELESCOPE Sipping technology is an evolutionary development from previous ABB fuel leak systems used in LWR reactors. The system utilizes the existing dynamics that cause numerous fission products to leak from a failed fuel rod when the fuel assembly is raised from a reactor core during core fuel alterations. The system can also be used by repair work in pool side inspection in order to detect leaking rods or to verify reconstituted assemblies as non leakers. (author)

  17. Louisiana SIP: LAC 33:III Ch. 7 - Table 2 - Ambient Air--Methods of Contaminant Measurements; SIP effective 1989-05-08 (LAc49) and 1989-08-14 (LAc50) to 2011-08-03 (LAd34 - Moved to Section 711 and revised [adds PM-2.5])

    Science.gov (United States)

    Louisiana SIP: LAC 33:III Ch. 7 - Table 2 - Ambient Air--Methods of Contaminant Measurements; SIP effective 1989-05-08 (LAc49) and 1989-08-14 (LAc50) to 2011-08-03 (LAd34 - Moved to Section 711 and revised [adds PM-2.5])

  18. Joint inversion of NMR and SIP data to estimate pore size distribution of geomaterials

    Science.gov (United States)

    Niu, Qifei; Zhang, Chi

    2018-03-01

    There are growing interests in using geophysical tools to characterize the microstructure of geomaterials because of the non-invasive nature and the applicability in field. In these applications, multiple types of geophysical data sets are usually processed separately, which may be inadequate to constrain the key feature of target variables. Therefore, simultaneous processing of multiple data sets could potentially improve the resolution. In this study, we propose a method to estimate pore size distribution by joint inversion of nuclear magnetic resonance (NMR) T2 relaxation and spectral induced polarization (SIP) spectra. The petrophysical relation between NMR T2 relaxation time and SIP relaxation time is incorporated in a nonlinear least squares problem formulation, which is solved using Gauss-Newton method. The joint inversion scheme is applied to a synthetic sample and a Berea sandstone sample. The jointly estimated pore size distributions are very close to the true model and results from other experimental method. Even when the knowledge of the petrophysical models of the sample is incomplete, the joint inversion can still capture the main features of the pore size distribution of the samples, including the general shape and relative peak positions of the distribution curves. It is also found from the numerical example that the surface relaxivity of the sample could be extracted with the joint inversion of NMR and SIP data if the diffusion coefficient of the ions in the electrical double layer is known. Comparing to individual inversions, the joint inversion could improve the resolution of the estimated pore size distribution because of the addition of extra data sets. The proposed approach might constitute a first step towards a comprehensive joint inversion that can extract the full pore geometry information of a geomaterial from NMR and SIP data.

  19. Design and construction of the SIPPING for fuels of the TRIGA Mark III reactor; Diseno y construccion del SIPPING para combustibles del reactor TRIGA Mark III

    Energy Technology Data Exchange (ETDEWEB)

    Castaneda J, G.; Delfin L, A.; Alvarado P, R.; Mazon R, R.; Ortega V, B. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)]. e-mail: adl@nuclear.inin.mx

    2003-07-01

    The sipping technique, it has been used by several possessors of nuclear research reactors in its irradiated nuclear fuels, likewise in some fuel storage sites, with the objective of to determine the quantity of radioactivity that the fuel liberates in the means in that it is. The irradiated fuel in storage of some nuclear research reactors, its can have cracks that cross the cladding of the same one, generating the liberation of fission products that its need to determine to maintain safety measures appropriate as much as the fuel as of the facilities where they are. It doesn't exist until now, some method published for the non destructive sipping test technique. Based on that described, the Reactor Department of the National Institute of Nuclear Research, it has designed and built an inspection system of irradiated fuel that it will allow the detection of gassy fission products in site, and solids by means of the measurement of the activity of the Cs-137 contained in water samples. (Author)

  20. The influence of an undergraduate scientific initiation programme on the professional profile of new physicians.

    Science.gov (United States)

    Cyrillo, Raphael Joaquim Teles; Setúbal, Sérgio; da Silva, Cyro Teixeira; Velarde, Luis Guillermo Coca; de Mattos, Ana Carolina Musser Tavares; Cardoso, Renato Bergallo Bezerra; Cardoso, Gilberto Perez

    2010-01-01

    This paper studies the influence of a Scientific Initiation Programme (SIP) on the professional profile of new doctors from a Brazilian university. Evaluate fifty-two new doctors divided into two groups matched by sex, age and academic performance and differing only in participation in the SIP. Professional and socioeconomic data were collected, including schooling of parents; average income before, during and after the medical course; current professional situation; results of exams for civil servant recruitment; and titles and degrees obtained after graduation. Significant differences were found only in civil servant recruitment exam results (p = 0.0098) and in income after graduation (p = 0.02), which were both higher in the non-SIP group. Only one doctor got a M.Sc. degree after graduation, but many of them in both groups obtained technical titles, and had papers presented at congresses or published. Apparently, taking part in a SIP led to lower income and worse civil servant recruitment exam results. However, this may only reflect a transient phase in a long-term process. New research currently under way will answer this remaining question, now that more time has elapsed since graduation.

  1. Accountability: Evaluating the impact of emission control policies on air pollutant levels and health outcomes

    Science.gov (United States)

    Presentation on examining the impacts of an actual regulatory action (NOx SIP Call) on human health. We examined respiratory-related hospital admissions before and after the implementation of the NOx SIP Call. In addition, we found that enriched exposure information (incorporat...

  2. Safety and immunogenicity of an oral DNA vaccine encoding Sip of Streptococcus agalactiae from Nile tilapia Oreochromis niloticus delivered by live attenuated Salmonella typhimurium.

    Science.gov (United States)

    Huang, L Y; Wang, K Y; Xiao, D; Chen, D F; Geng, Y; Wang, J; He, Y; Wang, E L; Huang, J L; Xiao, G Y

    2014-05-01

    Attenuated Salmonella typhimurium SL7207 was used as a carrier for a reconstructed DNA vaccine against Streptococcus agalactiae. A 1.02 kb DNA fragment, encoding for a portion of the surface immunogenic protein (Sip) of S. agalactiae was inserted into pVAX1. The recombinant plasmid pVAX1-sip was transfected in EPC cells to detect the transient expression by an indirect immunofluorescence assay, together with Western blot analysis. The pVAX1-sip was transformed by electroporation into SL7207. The stability of pVAX1-sip into Salmonella was over 90% after 50 generations with antibiotic selection in vitro while remained stable over 80% during 35 generations under antibiotic-free conditions. The LD50 of SL/pVAX1-sip was 1.7 × 10(11) CFU/fish by intragastric administration which indicated a quite low virulence. Tilapias were inoculated orally at 10(8) CFU/fish, the recombinant bacteria were found present in intestinal tract, spleens and livers and eventually eliminated from the tissues 4 weeks after immunization. Fish immunized at 10(7), 10(8) and 10(9) CFU/fish with different immunization times caused various levels of serum antibody and an effective protection against lethal challenge with the wild-type strain S. agalactiae. Integration studies showed that the pVAX1-sip did not integrate with tilapia chromosomes. The DNA vaccine SL/pVAX1-sip was proved to be safe and effective in protecting tilapias against S. agalactiae infection. Copyright © 2014 Elsevier Ltd. All rights reserved.

  3. 78 FR 68005 - Approval and Promulgation of Implementation Plans; Mississippi; Transportation Conformity SIP...

    Science.gov (United States)

    2013-11-13

    ...] Approval and Promulgation of Implementation Plans; Mississippi; Transportation Conformity SIP--Memorandum... transportation conformity criteria and procedures related to interagency consultation and enforceability of... conformity process to allow direct consultation among agencies at the Federal, state and local levels. This...

  4. Development and feasibility of a Swallowing intervention Package (SiP) for patients receiving radiotherapy treatment for head and neck cancer-the SiP study protocol.

    Science.gov (United States)

    Wells, Mary; King, Emma; Toft, Kate; MacAulay, Fiona; Patterson, Joanne; Dougall, Nadine; Hulbert-Williams, Nick; Boa, Sally; Slaven, Eleanor; Cowie, Julie; McGarva, John; Niblock, Patricia Gail; Philp, Julie; Roe, Justin

    2016-01-01

    Head and neck cancer (HNC) is the sixth most common cancer worldwide, and the functional, psychological and social consequences of HNC cancer and its treatment can be severe and chronic. Dysphagia (swallowing problems) affects up to two thirds of patients undergoing combined chemoradiotherapy. Recent reviews suggest that prophylactic swallowing exercises may improve a range of short- and long-term outcomes; however, the importance of psychological and behavioural factors on adherence to swallowing exercises has not been adequately studied. This study aims to develop and test the feasibility of a Swallowing intervention Package (SiP) designed in partnership with patients, speech and language therapists (SLTs) and other members of the head and neck multi-disciplinary team (MDT), for patients undergoing chemoradiotherapy (CRT) or radiotherapy (RT) for head and neck cancer. This feasibility study uses quantitative and qualitative research methods, within a quasi-experimental design, to assess whether patients will tolerate and adhere to the SiP intervention, which aspects of the intervention can be implemented and which cannot, whether treatment fidelity can be achieved across different contexts, whether study processes and outcome measures will be feasible and acceptable and to what extent the intervention is likely to have an impact on swallowing dysfunction and quality of life. Patients are being recruited from five sites in Scotland and England (three interventions and two usual care). The SLT based in the relevant intervention centre teaches the exercise programme and provides supporting materials. A combination of patient-reported outcome measures (PROMs), adherence measures and clinical swallowing assessments are used prior to intervention (baseline), at the end of treatment, 3 and 6 months post-treatment. This collaborative study has taken a unique approach to the development of a patient-centred and evidence-based swallowing intervention. The introduction of

  5. Sipping test on a failed MTR fuel element

    International Nuclear Information System (INIS)

    Terremoto, Luis Antonio Albiac; Zeituni, Carlos Alberto; Silva, Antonio Teixeira e; Perrotta, Jose Augusto; Silva, Jose Eduardo Rosa da

    2002-01-01

    This work describes sipping tests performed on MTR fuel elements of the IEA-R1 research reactor, in order to determinate which one failed in the core during a routine operation of the reactor. radioactive iodine isotopes 131 I and 133 I, employed as failure indicators, were detected in samples corresponding to the fuel element IEA-156. The specific activity of each sample, as well as the average leaking rate, were measured for 137 Cs. The nuclear fuels U 3 O 8 - Al dispersion and U - Al alloy were compared concerning their measured average leaking rates of 137 Cs. (author)

  6. The Influence of an undergraduate scientific initiation programme onn the professional profile of new physicians.

    Science.gov (United States)

    Joaquim Teles Cyrillo, Raphael; Setúbal, Sérgio; da Silva Júnior, Cyro Teixeira; Guillermo Coca Velarde, Luis; de Mattos, Ana Carolina Musser Tavares; Bezerra Cardoso, Renato Bergallo; Cardoso, Gilberto Perez

    2010-01-01

    This paper studies the influence of a Scientific Initiation Programme (SIP) on the professional profile of new doctors from a Brazilian university. Evaluate fifty-two new doctors divided into two groups matched by sex, age and academic performance and differing only in participation in the SIP. Professional and socioeconomic data were collected, including schooling of parents; average income before, during and after the medical course; current professional situation; results of exams for civil servant recruitment; and titles and degrees obtained after graduation. Significant differences were found only in civil servant recruitment exam results (p=0.0098) and in income after graduation (p=0.02), which were both higher in the non-SIP group. Only one doctor got a M.Sc. degree after graduation, but many of them in both groups obtained technical titles, and had papers presented at congresses or published. Apparently, taking part in a SIP led to lower income and worse civil servant recruitment exam results. However, this may only reflect a transient phase in a long-term process. New research currently under way will answer this remaining question, now that more time has elapsed since graduation. Rev Port Pneumol 2010; XVI (5): 797-808. © 2010 Sociedade Portuguesa de Pneumologia/SPP.

  7. The impacts of network competence, knowledge sharing on service innovation performance: Moderating role of relationship quality

    Directory of Open Access Journals (Sweden)

    Zaoquan Jian

    2013-03-01

    Full Text Available Purpose: To examine how network competence, knowledge sharing and relationship quality affect service innovation performanceDesign/methodology/approach: Empirical ResearchFindings: 1 Both enterprise’s network competence and knowledge sharing have distinct positive impact on SIP; (2 Knowledge sharing partially mediates the effect of network competence on SIP. (3 Relationship quality positively moderates the effect of network competence on knowledge sharing, and the effect of knowledge sharing on SIP. (4 Relationship quality does not positively moderate the effect of network competence on SIP.Originality/value: This study has enriched current understanding of the relationship among network competence, knowledge sharing, relationship quality and service innovation performance.

  8. Assessment of SIP Buildings for Sustainable Development in Rural China Using AHP-Grey Correlation Analysis.

    Science.gov (United States)

    Bai, Libiao; Wang, Hailing; Shi, Chunming; Du, Qiang; Li, Yi

    2017-10-25

    Traditional rural residential construction has the problems of high energy consumption and severe pollution. In general, with sustainable development in the construction industry, rural residential construction should be aimed towards low energy consumption and low carbon emissions. To help achieve this objective, in this paper, we evaluated four different possible building structures using AHP-Grey Correlation Analysis, which consists of the Analytic Hierarchy Process (AHP) and the Grey Correlation Analysis. The four structures included the traditional and currently widely used brick and concrete structure, as well as structure insulated panels (SIPs). Comparing the performances of economic benefit and carbon emission, the conclusion that SIPs have the best overall performance can be obtained, providing a reference to help builders choose the most appropriate building structure in rural China.

  9. Experience on wet storage spent fuel sipping at IEA-R1 Brazilian research reactor

    International Nuclear Information System (INIS)

    Perrotta, J.A.; Terremoto, L.A.A.; Zeituni, C.A.

    1998-01-01

    The IEA-R1 research reactor of the Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP) is a pool type reactor of B and W design, that has been operating since 1957 at a power of 2 MW. Irradiated (spent) fuels have been stored at the facility during the various years of operation. At present there are 40 spent fuel assemblies at dry storage, 79 spent fuel assemblies at wet storage and 30 fuel assemblies in the core. The oldest fuels are of United States origin, made with U-Al alloy, both of LEU and HEU MTR fuel type. Many of these fuel assemblies have corrosion pits along their lateral fuel plates. These pits originate by galvanic corrosion between the fuel plate and the stainless steel storage racks. As a consequence of the possibility of sending the irradiated old fuels back the U.S.A., sipping tests were performed with the spent fuel assemblies. The reason for this was to evaluate their 137 Cs leaking rate, if any. This work describes the procedure and methodology used to perform the sipping tests with the fuel assemblies at the storage pool, and presents the results obtained for the 137 Cs sipping water activity for each fuel assembly. A correlation is made between the corrosion pits and the activity values measured. A 137 Cs leaking rate is determined and compared to the criteria established for canning spent fuel assemblies before shipment

  10. Scaling of ion implanted Si:P single electron devices

    International Nuclear Information System (INIS)

    Escott, C C; Hudson, F E; Chan, V C; Petersson, K D; Clark, R G; Dzurak, A S

    2007-01-01

    We present a modelling study on the scaling prospects for phosphorus in silicon (Si:P) single electron devices using readily available commercial and free-to-use software. The devices comprise phosphorus ion implanted, metallically doped (n + ) dots (size range 50-500 nm) with source and drain reservoirs. Modelling results are compared to measurements on fabricated devices and discussed in the context of scaling down to few-electron structures. Given current fabrication constraints, we find that devices with 70-75 donors per dot should be realizable. We comment on methods for further reducing this number

  11. Scaling of ion implanted Si:P single electron devices

    Energy Technology Data Exchange (ETDEWEB)

    Escott, C C [Centre for Quantum Computer Technology, School of Electrical Engineering and Telecommunications, UNSW, Sydney, NSW 2052 (Australia); Hudson, F E [Centre for Quantum Computer Technology, School of Electrical Engineering and Telecommunications, UNSW, Sydney, NSW 2052 (Australia); Chan, V C [Centre for Quantum Computer Technology, School of Electrical Engineering and Telecommunications, UNSW, Sydney, NSW 2052 (Australia); Petersson, K D [Centre for Quantum Computer Technology, School of Electrical Engineering and Telecommunications, UNSW, Sydney, NSW 2052 (Australia); Clark, R G [Centre for Quantum Computer Technology, School of Physics, UNSW, Sydney, 2052 (Australia); Dzurak, A S [Centre for Quantum Computer Technology, School of Electrical Engineering and Telecommunications, UNSW, Sydney, NSW 2052 (Australia)

    2007-06-13

    We present a modelling study on the scaling prospects for phosphorus in silicon (Si:P) single electron devices using readily available commercial and free-to-use software. The devices comprise phosphorus ion implanted, metallically doped (n{sup +}) dots (size range 50-500 nm) with source and drain reservoirs. Modelling results are compared to measurements on fabricated devices and discussed in the context of scaling down to few-electron structures. Given current fabrication constraints, we find that devices with 70-75 donors per dot should be realizable. We comment on methods for further reducing this number.

  12. Security Analysis System to Detect Threats on a SIP VoIP Infrasctructure Elements

    Directory of Open Access Journals (Sweden)

    Filip Rezac

    2011-01-01

    Full Text Available SIP PBX is definitely the alpha and omega of any IP telephony infrastructure and frequently also provides other services than those related to VoIP traffic. These exchanges are, however, very often the target of attacks by external actors. The article describes a system that was developed on VSB-TU Ostrava as a testing tool to verify if the target VoIP PBX is adequately secured and protected against any real threats. The system tests the SIP element for several usually occurring attacks and it compiles evaluation of its overall security on the basis of successfully or unsuccessfully penetrations. The article describes the applications and algorithms that are used by system and the conclusion consists recommendations and guidelines to ensure effective protection against VoIP PBX threats. The system is designed as an open-source web application, thus allowing independent access and is fully extensible to other test modules.

  13. Coupled RNA-SIP and metatranscriptomics of active chemolithoautotrophic communities at a deep-sea hydrothermal vent.

    Science.gov (United States)

    Fortunato, Caroline S; Huber, Julie A

    2016-08-01

    The chemolithoautotrophic microbial community of the rocky subseafloor potentially provides a large amount of organic carbon to the deep ocean, yet our understanding of the activity and metabolic complexity of subseafloor organisms remains poorly described. A combination of metagenomic, metatranscriptomic, and RNA stable isotope probing (RNA-SIP) analyses were used to identify the metabolic potential, expression patterns, and active autotrophic bacteria and archaea and their pathways present in low-temperature hydrothermal fluids from Axial Seamount, an active submarine volcano. Metagenomic and metatranscriptomic results showed the presence of genes and transcripts for sulfur, hydrogen, and ammonium oxidation, oxygen respiration, denitrification, and methanogenesis, as well as multiple carbon fixation pathways. In RNA-SIP experiments across a range of temperatures under reducing conditions, the enriched (13)C fractions showed differences in taxonomic and functional diversity. At 30 °C and 55 °C, Epsilonproteobacteria were dominant, oxidizing hydrogen and primarily reducing nitrate. Methanogenic archaea were also present at 55 °C, and were the only autotrophs present at 80 °C. Correspondingly, the predominant CO2 fixation pathways changed from the reductive tricarboxylic acid (rTCA) cycle to the reductive acetyl-CoA pathway with increasing temperature. By coupling RNA-SIP with meta-omics, this study demonstrates the presence and activity of distinct chemolithoautotrophic communities across a thermal gradient of a deep-sea hydrothermal vent.

  14. 78 FR 22827 - Approval and Promulgation of Implementation Plans; State of Kansas; Infrastructure SIP...

    Science.gov (United States)

    2013-04-17

    ... strategies to reduce air pollution. Based upon review of the state's infrastructure SIP submissions for the... revisions; (I) Nonattainment areas; (J) Consultation with government officials, public notification... pollution with the Secretary of Health and Environment (``Secretary''). The Secretary in turn administers...

  15. Economic impact profiling of CBRN events: focusing on biological incidents.

    Science.gov (United States)

    Cavallini, Simona; Bisogni, Fabio; Mastroianni, Marco

    2014-12-01

    Chemical, biological, radiological and nuclear (CBRN) incidents, both caused accidentally by human error or natural/technological events and determined intentionally as criminal/malicious/terroristic acts, have consequences that could be differently characterized. In the last years many efforts to analyze the economic impact of terrorist threat have been carried out, while researches specifically concerning CBRN events have not been extensively undertaken. This paper in particular aims at proposing a methodological approach for studying macro-level economic impact profiles of biological incidents caused by weaponized and non-weaponized materials. The suggested approach investigates the economic consequences of biological incidents according to two main dimensions: type of large-scale effect and persistence of effect. Biological incident economic impacts are analyzed taking into account the persistence of effect during time as short-term impact (i.e. immediately after the incident), medium-term impact (i.e. by a month) and long-term impact (i.e. by years). The costs due to preventive countermeasure against biological threats (e.g. prevention, protection and preparedness expenses) are not taken into account. To this purpose, information on the key features of past biological incidents can be used as case studies to try to build impact profiles taking into account the proposed two main dimensions. Consequence management and effect mitigation of CBRN emergencies and disasters may benefit from an ex ante definition of the impact profiling related to this kind of incidents. The final goal of this paper is to define an approach to organize information on possible biological events according to their impact profile for supporting more effective and efficient first responders' prompt actions and policy makers' strategic decisions after the event occurrence.

  16. SIP-Based Single Neuron Stochastic Predictive Control for Non-Gaussian Networked Control Systems with Uncertain Metrology Delays

    Directory of Open Access Journals (Sweden)

    Xinying Xu

    2018-06-01

    Full Text Available In this paper, a novel data-driven single neuron predictive control strategy is proposed for non-Gaussian networked control systems with metrology delays in the information theory framework. Firstly, survival information potential (SIP, instead of minimum entropy, is used to formulate the performance index to characterize the randomness of the considered systems, which is calculated by oversampling method. Then the minimum values can be computed by optimizing the SIP-based performance index. Finally, the proposed strategy, minimum entropy method and mean square error (MSE are applied to a networked motor control system, and results demonstrated the effectiveness of the proposed strategy.

  17. Comparative MiRNA Expressional Profiles and Molecular Networks in Human Small Bowel Tissues of Necrotizing Enterocolitis and Spontaneous Intestinal Perforation.

    Directory of Open Access Journals (Sweden)

    Pak Cheung Ng

    Full Text Available Necrotizing enterocolitis (NEC and spontaneous intestinal perforation (SIP are acute intestinal conditions which could result in mortality and severe morbidity in preterm infants. Our objective was to identify dysregulated micro-RNAs (miRNAs in small bowel tissues of NEC and SIP, and their possible roles in disease pathophysiology.We performed differential miRNA arrays on tissues of NEC (n = 4, SIP (n = 4 and surgical-control (Surg-CTL; n = 4, and validated target miRNAs by qPCR (n = 10 each group. The association of target miRNAs with 52 dysregulated mRNAs was investigated by bioinformatics on functional and base-pair sequence algorithms, and correlation in same tissue samples.We presented the first miRNA profiles of NEC, SIP and Surg-CTL intestinal tissues in preterm infants. Of 28 validated miRNAs, 21 were significantly different between NEC or SIP and Surg-CTL. Limited overlapping in the aberrant expression of miRNAs between NEC and SIP indicated their distinct molecular mechanisms. A proposed network of dysregulated miRNA/mRNA pairs in NEC suggested interaction at bacterial receptor TLR4 (miR-31, miR-451, miR-203, miR-4793-3p, mediated via key transcription factors NFKB2 (miR-203, AP-1/FOSL1 (miR-194-3p, FOXA1 (miR-21-3p, miR-431 and miR-1290 and HIF1A (miR-31, and extended downstream to pathways of angiogenesis, arginine metabolism, cell adhesion and chemotaxis, extracellular matrix remodeling, hypoxia/oxidative stress, inflammation and muscle contraction. In contrast, upregulation of miR-451 and miR-223 in SIP suggested modulation of G-protein-mediated muscle contraction.The robust response of miRNA dysregulation in NEC and SIP, and concerted involvement of specific miRNAs in the molecular networks indicated their crucial roles in mucosa integrity and disease pathophysiology.

  18. Análisis de ciclo de vida simplificado aplicado a viviendas de paneles SIP (structural insulated panels

    Directory of Open Access Journals (Sweden)

    Juan Pablo Cárdenas

    2015-04-01

    Full Text Available A medida que los asuntos ambientales se vuelven más importantes, las construcciones se han enfocado en su eficiencia energética y la energía necesaria para construir y producir los materiales. Esta investigación muestra un estudio de Análisis de Ciclo de Vida simplificado de energía operacional y energía contenida de cuatro viviendas nuevas ubicadas en Temuco, Chile, estructuradas con paneles SIP (Structural insulated panel para cuantificar la energía en cada etapa de este sistema de construcción. Para obtener la energía contenida, fueron utilizadas dos bases de datos internacionales para cuantificar la energía de cada material y se determinó la energía contenida en el proceso relacionado a la estructura de paneles SIP a través de mediciones en una compañía especializada en construcción de paneles SIP. Para la energía operacional, se llevaron a cabo modelos computacionales con el software Design Builder y se proyectó esta energía con una vida útil de 50 años. El análisis de la información obtenida muestra que la energía contenida por procesos de construcción representa cerca del 1.7% de la energía contenida y mientras que el total de energía contenida representa el 11% de la energía del ciclo de vida total de las viviendas, el remanente 89% representa la energía de operación. Por otro lado, observamos que las viviendas con paneles SIP generan cifras cercanas al 60% en ahorro en demanda energética, comparadas a las viviendas de mampostería estructural normalmente construidas en esta ciudad.

  19. 77 FR 29351 - Disease, Disability, and Injury Prevention and Control; Special Interest Projects (SIPs): Initial...

    Science.gov (United States)

    2012-05-17

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and Control; Special Interest Projects (SIPs): Initial Review The meeting.... L. 92-463), the Centers for Disease Control and Prevention (CDC) announces the aforementioned...

  20. 76 FR 27649 - Disease, Disability, and Injury Prevention and Control Special Interest Projects (SIPs): Initial...

    Science.gov (United States)

    2011-05-12

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and Control Special Interest Projects (SIPs): Initial Review The meeting... Committee Act (Pub. L. 92-463), the Centers for Disease Control and Prevention (CDC) announces the...

  1. 75 FR 30410 - Disease, Disability, and Injury Prevention and Control Special Interest Project (SIP): Provider...

    Science.gov (United States)

    2010-06-01

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and Control Special Interest Project (SIP): Provider and Public Health... Federal Advisory Committee Act (Pub. L. 92-463), the Centers for Disease Control and Prevention (CDC...

  2. Impact of Minnesota's "Profile of Learning"

    Directory of Open Access Journals (Sweden)

    Patricia G. Avery

    2003-02-01

    Full Text Available In 1990, the Minnesota State Board of Education declared its intention to develop a "results-oriented graduation requirement" based on student achievement as opposed to the usual credit/course completion requirement. In addition to a traditional test of basic skills, the state began developing the Profile of Learning, a set of performance-based standards grounded in a constructivist educational philosophy, an approach that differs from the content-based standards found in many states. The Profile was controversial from its inception. Conservatives characterized the Profile as too process- oriented and as lacking subject-matter content; teachers reported that the Profile required a significant amount of additional teacher preparation time; and parents, who were not adequately informed about the Profile, questioned the purpose of the Profile. Teachers were frustrated with the confusing and sometimes contradictory directions they received from the Minnesota Department of Children, Families, and Learning charged with implementing the Profile. In 2000-2001, we surveyed and interviewed selected secondary English and social studies teachers in the state about their perceptions of the Profile’s impact on teaching and learning. Among the positive perceptions was an increase in students’ higher order thinking, students’ understanding of criteria for quality work, and teachers conversations with one another about instructional issues. Increased teacher preparation time and decreased enjoyment of teaching were among the negative perceptions. Teachers also experienced difficulty adopting performance assessment techniques. When teachers believed they received effective preparation and adequate resources for working with the Profile, they were much more likely to report beneficial effects in terms of teaching and learning. The majority of teachers, however, rated their preparation and resources as "fair" or "poor." Results are discussed in terms of

  3. 78 FR 50360 - Approval and Promulgation of Air Quality Implementation Plans; Indiana; Infrastructure SIP...

    Science.gov (United States)

    2013-08-19

    ... ensure that the structural components of each state's air quality management program are adequate to meet... SIP. The Indiana Department of Environmental Management (IDEM) has requested that EPA approve these... ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 52 [EPA-R05-OAR-2011-0888; EPA-R05-OAR-2011-0969; EPA...

  4. The strategy of the shelter implementation plan (SIP) performance

    International Nuclear Information System (INIS)

    Geras'ko, V.N.; Nosovskij, A.V.

    1999-01-01

    In 1997 the 'Shelter Implementation Plan' (SIP) was developed it's purpose was to transform Unit 4 of the Chernobyl NPP into the ecologically safe system. The Plan was developed by common efforts of the Ukrainian scientists, CES representatives and experts from the United States of America. The fact that there are no nuclear and radiation safety criteria for the projects will result into the situation when different designers might use within the various project tasks various design criteria. Till now o exact date for the constructions stabilization activities has been defined, and it creates a kind of on definiteness while developing the Radioactive Waste Management strategy and Safe Confinement

  5. SiP monolayers: New 2D structures of group IV-V compounds for visible-light photohydrolytic catalysts

    Science.gov (United States)

    Ma, Zhinan; Zhuang, Jibin; Zhang, Xu; Zhou, Zhen

    2018-06-01

    Because of graphene and phosphorene, two-dimensional (2D) layered materials of group IV and group V elements arouse great interest. However, group IV-V monolayers have not received due attention. In this work, three types of SiP monolayers were computationally designed to explore their electronic structure and optical properties. Computations confirm the stability of these monolayers, which are all indirect-bandgap semiconductors with bandgaps in the range 1.38-2.21 eV. The bandgaps straddle the redox potentials of water at pH = 0, indicating the potential of the monolayers for use as watersplitting photocatalysts. The computed optical properties demonstrate that certain monolayers of SiP 2D materials are absorbers of visible light and would serve as good candidates for optoelectronic devices.

  6. 77 FR 30292 - Disease, Disability, and Injury Prevention and Control Special Interest Project (SIP): Initial...

    Science.gov (United States)

    2012-05-22

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and Control Special Interest Project (SIP): Initial Review The meeting...)(2) of the Federal Advisory Committee Act (Pub. L. 92-463), the Centers for Disease Control and...

  7. 75 FR 30410 - Disease, Disability, and Injury Prevention and Control Special Interest Projects (SIPs): Outcomes...

    Science.gov (United States)

    2010-06-01

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and Control Special Interest Projects (SIPs): Outcomes of Screening... 10(a)(2) of the Federal Advisory Committee Act (Pub. L. 92- 463), the Centers for Disease Control and...

  8. Multivariate statistical monitoring as applied to clean-in-place (CIP) and steam-in-place (SIP) operations in biopharmaceutical manufacturing.

    Science.gov (United States)

    Roy, Kevin; Undey, Cenk; Mistretta, Thomas; Naugle, Gregory; Sodhi, Manbir

    2014-01-01

    Multivariate statistical process monitoring (MSPM) is becoming increasingly utilized to further enhance process monitoring in the biopharmaceutical industry. MSPM can play a critical role when there are many measurements and these measurements are highly correlated, as is typical for many biopharmaceutical operations. Specifically, for processes such as cleaning-in-place (CIP) and steaming-in-place (SIP, also known as sterilization-in-place), control systems typically oversee the execution of the cycles, and verification of the outcome is based on offline assays. These offline assays add to delays and corrective actions may require additional setup times. Moreover, this conventional approach does not take interactive effects of process variables into account and cycle optimization opportunities as well as salient trends in the process may be missed. Therefore, more proactive and holistic online continued verification approaches are desirable. This article demonstrates the application of real-time MSPM to processes such as CIP and SIP with industrial examples. The proposed approach has significant potential for facilitating enhanced continuous verification, improved process understanding, abnormal situation detection, and predictive monitoring, as applied to CIP and SIP operations. © 2014 American Institute of Chemical Engineers.

  9. Experimental Evaluation of a SIP-Based Home Gateway with Multiple Wireless Interfaces for Domotics Systems

    Directory of Open Access Journals (Sweden)

    Rosario G. Garroppo

    2012-01-01

    Full Text Available In modern houses, the presence of sensors and actuators is increasing, while communication services and entertainment systems had long since settled into everyday life. The utilization of wireless communication technologies, such as ZigBee, Wi-Fi, and Bluetooth, is attractive because of their short installation times and low costs. The research is moving towards the integration of the various home appliances and devices into a single domotics system, able to exploit the cooperation among the diverse subsystems and offer the end-user a single multiservice platform. In this scenario, the paper presents the experimental evaluation of a domotics framework centered on a SIP-based home gateway (SHG. While SIP is used to build a common control plane, the SHG is in charge of translating the user commands from and to the specific domotics languages. The analysis has been devoted to assess both the performance of the SHG software framework and the negative effects produced by the simultaneous interference among the three widespread wireless technologies.

  10. Design and construction of the SIPPING for fuels of the TRIGA Mark III reactor

    International Nuclear Information System (INIS)

    Castaneda J, G.; Delfin L, A.; Alvarado P, R.; Mazon R, R.; Ortega V, B.

    2003-01-01

    The sipping technique, it has been used by several possessors of nuclear research reactors in its irradiated nuclear fuels, likewise in some fuel storage sites, with the objective of to determine the quantity of radioactivity that the fuel liberates in the means in that it is. The irradiated fuel in storage of some nuclear research reactors, its can have cracks that cross the cladding of the same one, generating the liberation of fission products that its need to determine to maintain safety measures appropriate as much as the fuel as of the facilities where they are. It doesn't exist until now, some method published for the non destructive sipping test technique. Based on that described, the Reactor Department of the National Institute of Nuclear Research, it has designed and built an inspection system of irradiated fuel that it will allow the detection of gassy fission products in site, and solids by means of the measurement of the activity of the Cs-137 contained in water samples. (Author)

  11. Protective efficacy of cationic-PLGA microspheres loaded with DNA vaccine encoding the sip gene of Streptococcus agalactiae in tilapia.

    Science.gov (United States)

    Ma, Yan-Ping; Ke, Hao; Liang, Zhi-Ling; Ma, Jiang-Yao; Hao, Le; Liu, Zhen-Xing

    2017-07-01

    Streptococcus agalactiae (S. agalactiae) is an important fish pathogen, which has received more attention in the past decade due to the increasing economic losses in the tilapia industry worldwide. As existing effective vaccines of S. agalactiae in fish have obvious disadvantage, to select immunoprotective antigens and package materials would undoubtedly contribute to the development of novel oral vaccines. In the present study, surface immunogenic protein (sip) was selected from the S. agalactiae serovar I a genomes as immunogenic protein in DNA vaccine form with cationic chitosan and biodegradable and biocompatible PLGA. The pcSip plasmid in cationic-PLGA was successfully expressed in tissues of immunized tilapia and the immunogenicity was assessed in tilapia challenge model. A significant increase was observed in the cytokine levels of IL-1β, TNF-α, CC1, CC2 in spleen and kidney tissues. Furthermore, immunized tilapia conferred different levels of protection against challenge with a lethal dose of highly virulent serovar I a S. agalactiae. Our results indicated that the pcSip plasmid in cationic-PLGA induced high level of antibodies and protection against S. agalactiae infection, could be effective oral DNA vaccine candidates. Copyright © 2017 Elsevier Ltd. All rights reserved.

  12. Implementasi Server VoIP Berbasis SIP Pada LAN Nirkabel

    Directory of Open Access Journals (Sweden)

    Mohammad Shoffa Al Arofat

    2013-03-01

    Full Text Available Voice over Internet Protocol (VoIP merupakan teknologi yang memungkinkan percakapan suara jarak jauh melalui protokol internet. Dalam telekomunikasi, diperlukan teknologi pensinyalan yang berguna untuk membangun, mengawasi, dan melepas hubungan antara dua titik. Salah satu teknologi pensinyalan yang banyak digunakan untuk VoIP adalah Session Initiation Protocol, dengan implementasinya yang berupa perangkat lunak Open SIP Server. Selain pensinyalan, ada beberapa parameter yang perlu diperhatikan dalam implementasi VoIP, yaitu Mean Opinion Score (MOS, network impairment, dan bandwidth. Pengujian dilakukan terhadap enam codec, yaitu G.722, PCMA, PCMU, Speex, GSM, dan BV16. Berdasarkan hasil analisis dapat diambil kesimpulan bahwa codec yang menggunakan bandwidth paling rendah adalah Speex (27,12 kbps; Rata-rata delay yang dihasilkan oleh sipdroid lebih baik daripada jitsi.

  13. RGC32 induces epithelial-mesenchymal transition by activating the Smad/Sip1 signaling pathway in CRC.

    Science.gov (United States)

    Wang, Xiao-Yan; Li, Sheng-Nan; Zhu, Hui-Fang; Hu, Zhi-Yan; Zhong, Yan; Gu, Chuan-Sha; Chen, Shi-You; Liu, Teng-Fei; Li, Zu-Guo

    2017-05-04

    Response gene to complement 32 (RGC32) is a transcription factor that regulates the expression of multiple genes involved in cell growth, viability and tissue-specific differentiation. However, the role of RGC32 in tumorigenesis and tumor progression in colorectal cancer (CRC) has not been fully elucidated. Here, we showed that the expression of RGC32 was significantly up-regulated in human CRC tissues versus adjacent normal tissues. RGC32 expression was significantly correlated with invasive and aggressive characteristics of tumor cells, as well as poor survival of CRC patients. We also demonstrated that RGC32 overexpression promoted proliferation, migration and tumorigenic growth of human CRC cells in vitro and in vivo. Functionally, RGC32 facilitated epithelial-mesenchymal transition (EMT) in CRC via the Smad/Sip1 signaling pathway, as shown by decreasing E-cadherin expression and increasing vimentin expression. In conclusion, our findings suggested that overexpression of RGC32 facilitates EMT of CRC cells by activating Smad/Sip1 signaling.

  14. Expected long-term outcome after a tibial shaft fracture

    DEFF Research Database (Denmark)

    Faergemann, C; Frandsen, P A; Röck, N D

    1999-01-01

    OBJECTIVE: A prospective study of 207 laymen and professionals answered a questionnaire regarding the expectations of the long-term outcome 6 months after a unilateral tibial shaft fracture. The aim was (1) to disclose the expected outcome after unilateral tibial shaft fracture, and (2) to compare...... these expectations with the outcome measured in patients. METHODS: There were five groups of nonpatients: (1) 42 orthopedic surgeons, (2) 36 physiotherapists, (3) 42 students, (4) 49 white collar workers, and (5) 38 blue collar workers. Outcome was measured by Sickness Impact Profile (SIP). The SIP scores were...

  15. Long-term effects of pallidal or subthalamic deep brain stimulation on quality of life in Parkinson's disease

    NARCIS (Netherlands)

    Volkmann, Jens; Albanese, Alberto; Kulisevsky, Jaime; Tornqvist, Aana-Lena; Houeto, Jean-Luc; Pidoux, Bernard; Bonnet, Anne-Marie; Mendes, Alexandre; Benabid, Alim-Louis; Fraix, Valerie; van Blercom, Nadege; Xie, Jing; Obeso, José; Rodriguez-Oroz, Maria Cruz; Guridi, Jurge; Schnitzler, Alfons; Timmermann, Lars; Gironell, Alexandre A.; Molet, Juan; Pascual-Sedano, Benta; Rehncrona, Stig; Moro, Elena; Lang, Anthony C.; Lozano, Andres M.; Bentivoglio, Anna Rita; Scerrati, Massimo; Contarino, Maria Fiorella; Romito, Luigi; Janssens, Marc; Agid, Yves

    2009-01-01

    We assessed the effects of deep brain stimulation of the subthalamic nucleus (STN-DBS) or internal pallidum (GPi-DBS) on health-related quality of life (HrQoL) in patients with advanced Parkinson's disease participating in a previously reported multicenter trial. Sickness Impact Profile (SIP)

  16. Spectral induced polarization (SIP) measurement of NAPL contaminated soils

    Science.gov (United States)

    Schwartz, N.; Huisman, J. A.; Furman, A.

    2010-12-01

    The potential applicability of spectral induce polarization (SIP) as a tool to map NAPLs (non aqueous phase liquids) contaminants at the subsurface lead researchers to investigate the electric signature of those contaminant on the spectral response. However, and despite the cumulative efforts, the effect of NAPL on the electrical properties of soil, and the mechanisms that control this effect are largely unknown. In this work a novel experiment is designed to further examine the effect of NAPL on the electrical properties of partially saturated soil. The measurement system that used is the ZEL-SIP04 impedance meter developed at the Forschungszentrum Julich, Germany. The system accurately (nominal phase precision of 0.1 mrad below 1 kHz) measures the phase and the amplitude of a material possessing a very low polarization (such as soil). The sample holder has a dimension of 60 cm long and 4.6 cm in diameter. Current and potential electrodes were made of brass, and while the current electrodes were inserted in full into the soil, the contact between the potential electrode and the soil was made through an Agarose bridge. Two types of soils were used: clean quartz sand, and a mixture of sand with clean Bentonite. Each soil (sandy or clayey) was mixed with water to get saturation degree of 30%. Following the mixture with water, NAPL was added and the composite were mixed again. Packing was done by adding and compressing small portions of the soil to the column. A triplicate of each mixture was made with a good reproducible bulk density. Both for the sandy and clayey soils, the results indicate that additions of NAPL decrease the real part of the complex resistivity. Additionally, for the sandy soil this process is time depended, and that a further decrease in resistivity develops over time. The results are analyzed considering geometrical factors: while the NAPL is electrically insulator, addition of NAPL to the soil is expected to increase the connectivity of the

  17. 78 FR 41311 - Approval of Air Quality Implementation Plans; Indiana; Approval of “Infrastructure” SIP With...

    Science.gov (United States)

    2013-07-10

    ... copyrighted material, will be publicly-available only in hard copy. Publicly-available docket materials are available either electronically in www.regulations.gov or in hard copy at the U.S. Environmental Protection... SIP at 326 IAC 1-3-4(b)(8) that among other things, contained the Federally promulgated 2006 PM 2.5...

  18. Residual health status after Guillain-Barre syndrome

    NARCIS (Netherlands)

    Bernsen, RAJAM; Jacobs, HM; deJager, AEJ; vanderMeche, FGA

    To study the extent to which patients experience residual problems in daily functioning several years after having Guillain-Barre syndrome (GBS) a survey of 123 patients who had had Guillain-Barre syndrome three to six years previously was performed, using the sickness impact profile (SIP) for

  19. Experimental study of 112 Gb/s short reach transmission employing PAM formats and SiP intensity modulator at 1.3 μm.

    Science.gov (United States)

    Chagnon, Mathieu; Osman, Mohamed; Poulin, Michel; Latrasse, Christine; Gagné, Jean-Frédéric; Painchaud, Yves; Paquet, Carl; Lessard, Stéphane; Plant, David

    2014-08-25

    We present a Silicon Photonic (SiP) intensity modulator operating at 1.3 μm with pulse amplitude modulation formats for short reach transmission employing a digital to analog converter for the RF signal generator, enabling pulse shaping and precompensation of the transmitter's frequency response. Details of the SiP Mach-Zehnder interfometer are presented. We study the system performance at various bit rates, PAM orders and propagation distances. To the best of our knowledge, we report the first demonstration of a 112 Gb/s transmission over 10 km of SMF fiber operating below pre-FEC BER threshold of 3.8 × 10(-3) employing PAM-8 at 37.4 Gbaud using a fully packaged SiP modulator. An analytical model for the Q-factor metric applicable for multilevel PAM-N signaling is derived and accurately experimentally verified in the case of Gaussian noise limited detection. System performance is experimentally investigated and it is demonstrated that PAM order selection can be optimally chosen as a function of the desired throughput. We demonstrate the ability of the proposed transmitter to exhibit software-defined transmission for short reach applications by selecting PAM order, symbol rate and pulse shape.

  20. Differential impact of hyponatremia and hepatic encephalopathy on health-related quality of life and brain metabolite abnormalities in cirrhosis.

    Science.gov (United States)

    Ahluwalia, Vishwadeep; Wade, James B; Thacker, Leroy; Kraft, Kenneth A; Sterling, Richard K; Stravitz, R Todd; Fuchs, Michael; Bouneva, Iliana; Puri, Puneet; Luketic, Velimir; Sanyal, Arun J; Gilles, Hochong; Heuman, Douglas M; Bajaj, Jasmohan S

    2013-09-01

    Hyponatremia (HN) and hepatic encephalopathy (HE) together can impair health-related quality of life (HRQOL) and cognition in cirrhosis. We aimed at studying the effect of hyponatremia on cognition, HRQOL, and brain MR spectroscopy (MRS) independent of HE. Four cirrhotic groups (no HE/HN, HE alone, HN alone (sodium <130 mEq/L), HE+HN) underwent cognitive testing, HRQOL using Sickness Impact Profile (SIP: higher score is worse; has psychosocial and physical sub-scores) and brain MRS (myoinositol (mI) and glutamate+glutamine (Glx)), which were compared across groups. A subset underwent HRQOL testing before/after diuretic withdrawal. 82 cirrhotics (30 no HE/HN, 25 HE, 17 HE+HN, and 10 HN, MELD 12, 63% hepatitis C) were included. Cirrhotics with HN alone and without HE/HN had better cognition compared to HE groups (median abnormal tests no-HE/HN: 3, HN: 3.5, HE: 6.5, HE+HN: 7, p=0.008). Despite better cognition, HN only patients had worse HRQOL in total and psychosocial SIP while both HN groups (with/without HE) had a significantly worse physical SIP (p<0.0001, all comparisons). Brain MRS showed the lowest Glx in HN and the highest in HE groups (p<0.02). mI levels were comparably decreased in the three affected (HE, HE+HN, and HN) groups compared to no HE/HN and were associated with poor HRQOL. Six HE+HN cirrhotics underwent diuretic withdrawal which improved serum sodium and total/psychosocial SIP scores. Hyponatremic cirrhotics without HE have poor HRQOL despite better cognition than those with concomitant HE. Glx levels were lowest in HN without HE but mI was similar across affected groups. HRQOL improved after diuretic withdrawal. Hyponatremia has a complex, non-linear relationship with brain Glx and mI, cognition and HRQOL. Copyright © 2013 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

  1. Extended Password Recovery Attacks against APOP, SIP, and Digest Authentication

    Science.gov (United States)

    Sasaki, Yu; Wang, Lei; Ohta, Kazuo; Kunihiro, Noboru

    In this paper, we propose password recovery attacks against challenge-response authentication protocols. Our attacks use a message difference for a MD5 collision attack proposed in IEICE 2008. First, we show how to efficiently find a message pair that collides with the above message difference. Second, we show that a password used in authenticated post office protocol (APOP) can be recovered practically. We also show that the password recovery attack can be applied to a session initiation protocol (SIP) and digest authentication. Our attack can recover up to the first 31 password characters in a short time and up to the first 60 characters faster than the naive search method. We have implemented our attack and confirmed that 31 characters can be successfully recovered.

  2. Dynamic behavior of correlated electrons in the insulating doped semiconductor Si:P

    Energy Technology Data Exchange (ETDEWEB)

    Ritz, Elvira

    2009-06-04

    At low energy scales charge transport in the insulating Si:P is dominated by activated hopping between the localized donor electron states. Theoretical models for a disordered electronic system with a long-range Coulomb interaction are appropriate to interpret the electric conductivity spectra. With a novel and advanced method we perform broadband phase sensitive measurements of the reflection coefficient from 45 MHz up to 5 GHz, employing a vector network analyzer with a 2.4 mm coaxial sensor, which is terminated by the sample under test. While the material parameters (conductivity and permittivity) can be easily extracted from the obtained impedance data if the sample is metallic, no direct solution is possible if the material under investigation is an insulator. Focusing on doped semiconductors with largely varying conductivity and dielectric function, we present a closed calibration and evaluation procedure with an optimized theoretical and experimental complexity, based on the rigorous solution for the electromagnetic field inside the insulating sample, combined with the variational principle. Basically no limiting assumptions are necessary in a strictly defined parameter range. As an application of our new method, we have measured the complex broadband microwave conductivity of Si:P in a broad range of phosphorus concentration n/n{sub c} from 0.56 to 0.9 relative to the critical value n{sub c}=3.5 x 10{sup 18} cm{sup -3} of the metal-insulator transition driven by doping at temperatures down to 1.1 K, and studied unresolved issues of fundamental research concerning the electronic correlations and the metal-insulator transition. (orig.)

  3. Psychosocial work factors and first depressive episode: retrospective results from the French national SIP survey

    OpenAIRE

    Niedhammer , Isabelle; Chastang , Jean-François

    2015-01-01

    International audience; Objectives : The objective was to explore the associations between psychosocial work factors and first depressive episode. Additional objectives included the study of the frequency and duration of exposure, and the evaluation of the induction period between exposures and outcome and of the reversibility of the effects.Methods : The study was based on a sample of 13,648 men and women from the 2006 national representative French SIP survey. Retrospective evaluation was p...

  4. Impact of the Road Profile on Vehicle Deceleration

    Directory of Open Access Journals (Sweden)

    Vidas Žuraulis

    2012-11-01

    Full Text Available The article analyzes the impact of the longitudinal road profile on the efficiency of car braking estimated applying deceleration value. Different formulas are used for theoretical calculations, and therefore experimental brakes in different road slopes were performed to obtain the most accurate results. Deceleration, as one of the most important safety parameters, depends on the technical condition of the braking system, road conditions and structural and dynamic properties of the other car. Road alignments can significantly affect car manageability, because of weight transfer and extra track resistance, which may change the overall balance of the car and affect the nature of dynamic characteristics that may vary from certain critical values. The results of corrections to deceleration dependence on the road profile can be used for investigating traffic accidents, optimizing traffic control arrangements and implementing advanced systems for automotive active safety.

  5. 40 CFR 51.918 - Can any SIP planning requirements be suspended in 8-hour ozone nonattainment areas that have air...

    Science.gov (United States)

    2010-07-01

    ... suspended in 8-hour ozone nonattainment areas that have air quality data that meets the NAAQS? 51.918 Section 51.918 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... 8-hour Ozone National Ambient Air Quality Standard § 51.918 Can any SIP planning requirements be...

  6. Wave farm impact on the beach profile: A case study

    OpenAIRE

    Abanades, J; Greaves, D; Iglesias, G

    2014-01-01

    If wave energy is to become a fully-fledged renewable, its environmental impacts must be fully understood. The objective of the present work is to examine the impact of a wave farm on the beach profile through a case study. The methodology is based on two coupled numerical models: a nearshore wave propagation model and a morphodynamic model, which are run in two scenarios, both with and without the wave farm. Wave data from a nearby coastal buoy are used to prescribe the boundary conditions. ...

  7. Enhancing electron transport in Si:P delta-doped devices by rapid thermal anneal

    International Nuclear Information System (INIS)

    Goh, K. E. J.; Augarten, Y.; Oberbeck, L.; Simmons, M. Y.

    2008-01-01

    We address the use of rapid thermal anneal (RTA) to enhance electron mobility and phase coherent transport in Si:P δ-doped devices encapsulated by low temperature Si molecular beam epitaxy while minimizing dopant diffusion. RTA temperatures of 500-700 deg. C were applied to δ-doped layers encapsulated at 250 deg. C. From 4.2 K magnetotransport measurements, we find that the improved crystal quality after RTA increases the mobility/mean free path by ∼40% and the phase coherence length by ∼25%. Our results suggest that the initial capping layer has near optimal crystal quality and transport improvement achieved by a RTA is limited

  8. The Italian version of the 92-item Prodromal Questionnaire: Concurrent validity with the SIPS and factor analysis in a sample of 258 outpatients aged 11-36years.

    Science.gov (United States)

    Kotzalidis, Georgios D; Solfanelli, Andrea; Piacentino, Daria; Savoja, Valeria; Fiori Nastro, Paolo; Curto, Martina; Lindau, Juliana Fortes; Masillo, Alice; Brandizzi, Martina; Fagioli, Francesca; Raballo, Andrea; Gebhardt, Eva; Preti, Antonio; D'Alema, Marco; Fucci, Maria Rosa; Miletto, Roberto; Andropoli, Daniela; Leccisi, Donato; Girardi, Paolo; Loewy, Rachel L; Schultze-Lutter, Frauke

    2017-11-01

    Current early screeners for psychosis-risk states have still to prove ability in identifying at-risk individuals. Among screeners, the 92-item Prodromal Questionnaire (PQ-92) is often used. We aimed to assess the validity of its Italian translation in a large Italian adolescent and young adult help-seeking sample. We included all individuals aged 12-36years seeking help at psychiatric mental health services in a large semirural Roman area (534,600 population) who accepted to participate. Participants completed the Italian version of the PQ-92 and were subsequently assessed with the Structured Interview of Prodromal/Psychosis-Risk Syndromes (SIPS). We examined diagnostic accuracy (sensitivity, specificity, positive and negative predictive values, and positive and negative likelihood ratios) and content, concurrent, and convergent validity between PQ-92 and SIPS using Cronbach's alpha, Cohen's kappa, and Spearman's rho, respectively. We tested the validity of adopted cut-offs through Receiver Operating Characteristic (ROC) curves plotted against SIPS diagnoses and the instrument's factor-structure through Principal Component Analysis. PQ-92 showed high internal consistency, acceptable diagnostic accuracy and concurrent validity, and excellent convergent validity. ROC analyses pointed to scores of 18 on the Positive subscale and 36 on the total PQ-92 as best cut-offs. The Scree-test identified a four-factor solution as fitting best. Psychometric properties of Italian PQ-92 were satisfactory. Optimal cut-offs were confirmed at ≥18 on the positive subscale, but at ≥36 on the total scale was able to identify more SIPS-positive cases. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. Comparing architectural solutions of IPT application SDKs utilizing H.323 and SIP

    Science.gov (United States)

    Keskinarkaus, Anja; Korhonen, Jani; Ohtonen, Timo; Kilpelanaho, Vesa; Koskinen, Esa; Sauvola, Jaakko J.

    2001-07-01

    This paper presents two approaches to efficient service development for Internet Telephony. In first approach we consider services ranging from core call signaling features and media control as stated in ITU-T's H.323 to end user services that supports user interaction. The second approach supports IETF's SIP protocol. We compare these from differing architectural perspectives, economy of network and terminal development, and propose efficient architecture models for both protocols. In their design, the main criteria were component independence, lightweight operation and portability in heterogeneous end-to-end environments. In proposed architecture, the vertical division of call signaling and streaming media control logic allows for using the components either individually or combined, depending on the level of functionality required by an application.

  10. Only when the societal impact potential is high? A panel study of the relationship between public service motivation and performance

    DEFF Research Database (Denmark)

    Loon, Nina van; Kjeldsen, Anne Mette; Andersen, Lotte Bøgh

    Does the performance of public organizations benefit from high public service motivation (PSM) under all circumstances? This article studies whether the societal impact potential (SIP) – the degree to which the job provides opportunities to contribute to society of the job –moderates the relation......Does the performance of public organizations benefit from high public service motivation (PSM) under all circumstances? This article studies whether the societal impact potential (SIP) – the degree to which the job provides opportunities to contribute to society of the job –moderates...... the relationship between PSM and self-perceived performance, first on the individual level, and second on an organizational level. By shifting to the organizational level we are able to provide a test over time. Using organizational panel data from 2010 and 2012 on approximately 13.000 public employees, we...... (organizational level) or even no relationship (individual level) when SIP is low. This is an important insight for organizations that aim to enhance their performance through PSM as it shows that individual motives only contribute to performance when they are accounted for in the design of the work....

  11. Problems of radiation protection during SIP implementation on the Shelter

    International Nuclear Information System (INIS)

    Bogorad, V.I.; Litvinskaya, T.V.; Nikonov, D.A.

    2001-01-01

    One of the most urgent problems for today, during the SIP plans implementation of the Shelter transformation, is personnel radiation safety. The first of them assumes that a worker can be exposed to permitted annual dose during a short period of time with subsequent withdrawal of the person from radiation-hazardous activities. The second approach is based on the determination of derived dose limits that would provide for non-excess of the main limits on the assumption that a person is involved in radiation-hazardous work during the whole year. Radiation protection during practical activity should be formed on the basis of optimization principle. The optimization, in this case, implies that activities in the fields of ionizing radiation should be planned and performed in such way that, during their performance, the levels of individual doses and/or the quantity of exposed persons be as low as possible with taking into account the economic and social factors

  12. In-core sipping method for the identification of failed fuel assemblies

    International Nuclear Information System (INIS)

    Wu Zhongwang; Zhang Yajun

    2000-01-01

    The failed fuel assembly identification system is an important safety system which ensures safe operations of reactor and immediate treatment of failed fuel rod cladding. The system uses an internationally recognized method to identify failed fuel assemblies in a reactor with fuel element cases. The in-core sipping method is customary used to identify failed fuel assemblies during refueling or after fuel rod cladding failure accidents. The test is usually performed after reactor shutdown by taking samples from each fuel element case while the cases are still in their original core positions. The sample activity is then measured to identify failed fuel assemblies. A failed fuel assembly identification system was designed for the NHR-200 based on the properties of the NHR-200 and national requirements. the design provides an internationally recognized level of safety to ensure the safety of NHR-200

  13. The Chronic Illness Problem Inventory as a measure of dysfunction in chronic pain patients.

    Science.gov (United States)

    Romano, J M; Turner, J A; Jensen, M P

    1992-04-01

    Assessment of physical and psychosocial dysfunction is recognized as essential in chronic pain patient evaluation. One instrument, the Sickness Impact Profile (SIP), has demonstrated good reliability and validity as a measure of dysfunction among chronic pain patients. An alternate measure, the Chronic Illness Problem Inventory (CIPI), is shorter and more easily scored than the SIP, but as yet has not been applied widely to chronic pain problems. In the present study, 95 chronic low back pain patients completed the SIP, the CIPI, activity diaries, the McGill Pain Questionnaire (MPQ), and the Center for Epidemiologic Studies-Depression scale (CES-D), before participating in a chronic pain treatment study. Overt pain behaviors were also coded from videotapes of a standardized assessment protocol. Seventy-five subjects completed the measures post-treatment. The results indicate that although the SIP and the CIPI are significantly correlated and appear to be measuring similar constructs, there is also substantial unshared variance between them, suggesting that they may tap somewhat different aspects of dysfunction in chronic pain. The CIPI shows promise as a useful alternative measure of dysfunction in chronic low back pain patients, but requires further validation for this purpose.

  14. Impacts on the Voltage Profile of DC Distribution Network with DG Access

    Science.gov (United States)

    Tu, J. J.; Yin, Z. D.

    2017-07-01

    With the development of electronic, more and more distributed generations (DGs) access into grid and cause the research fever of direct current (DC) distribution network. Considering distributed generation (DG) location and capacity have great impacts on voltage profile, so use IEEE9 and IEEE33 typical circuit as examples, with DGs access in centralized and decentralized mode, to compare voltage profile in alternating and direct current (AC/DC) distribution network. Introducing the voltage change ratio as an evaluation index, so gets the general results on voltage profile of DC distributed network with DG access. Simulation shows that, in the premise of reasonable location and capacity, DC distribution network is more suitable for DG access.

  15. Impact of boiling conditions on the molecular and sensory profile of a vegetable broth.

    Science.gov (United States)

    Mougin, Alice; Mauroux, Olivier; Matthey-Doret, Walter; Barcos, Eugenia Maria; Beaud, Fernand; Bousbaine, Ahmed; Viton, Florian; Smarrito-Menozzi, Candice

    2015-02-11

    Low-pressure cooking has recently been identified as an alternative to ambient and high-pressure cooking to provide food with enhanced organoleptic properties. This work investigates the impact of the cooking process at different pressures on the molecular and sensory profile of a vegetable broth. Experimental results showed similar sensory and chemical profiles of vegetable broths when boiling at 0.93 and 1.5 bar, while an enhancement of sulfur volatile compounds correlated with a greater leek content and savory aroma was observed when boiling at low pressure (80 °C/0.48 bar). Thus, low-pressure cooking would allow preserving the most labile volatiles likely due to the lower water boiling temperature and the reduced level of oxygen. This study evidenced chemical and sensory impact of pressure during cooking and demonstrated that the flavor profile of culinary preparations can be enhanced by applying low-pressure conditions.

  16. Indirect enzyme-linked immunosorbent assay method based on Streptococcus agalactiae rSip-Pgk-FbsA fusion protein for detection of bovine mastitis.

    Science.gov (United States)

    Bu, Ri-E; Wang, Jin-Liang; Wu, Jin-Hua; Xilin, Gao-Wa; Chen, Jin-Long; Wang, Hua

    2017-03-01

    The aim of this study was to establish a rapid and accurate method for the detection of the Streptococcus agalactiae antibody (SA-Ab) to determine the presence of the bovine mastitis (BM)-causative pathogen. The multi-subunit fusion protein rSip-Pgk-FbsA was prokaryotically expressed and purified. The triple activities of the membrane surface-associated proteins Sip, phosphoglycerate kinase (Pgk), and fibronectin (FbsA) were used as the diagnostic antigens to establish an indirect enzyme-linked immunosorbent assay (ELISA) method for the detection of SA-Ab in BM. The optimal antigen coating concentration was 2 μg/mL, the optimal serum dilution was 1:160, and the optimal dilution of the enzyme-labeled secondary antibody was 1:6000. The sensitivity, specificity, and repeatability tests showed that the method established in this study had no cross-reaction with antibodies to Streptococcus pyogenes, Escherichia coli, Staphylococcus aureus, and Staphylococcus epidermidis in the sera. The results of the sensitivity test showed that a positive result could be obtained even if the serum dilution reached 1:12,800, indicating the high sensitivity and good repeatability of the method. The positive coincidence rate of this method was 98.6%, which is higher than that of previous tests established with the Sip or Pgk mono-antigen fusion protein, respectively, demonstrating the relatively higher sensitivity of this newly established method. The detection rate for 389 clinical samples was 46.53%. The indirect ELISA method established in this study could provide a more accurate and reliable serological method for the rapid detection of S. agalactiae in cases of BM.

  17. Visual inspection system and sipping design for spent fuel at TRIGA MARK III reactor of Mexico

    International Nuclear Information System (INIS)

    Delfin, A.; Mazon, R.

    2002-01-01

    In the framework of the Technical Cooperation Regional Project for Latin America RLA/4/018 for the biennium 2001-2002, one of the activities identified is the characterization of spent fuel. Of these activities an important one is not doubt the physical condition of spent fuel because an appropriate identification of the fuel status will prevent problems of fuel leaks, corrosion problems etc. As part of the activities of the project was decided that countries no having visual inspection and sipping systems should be very desirable to have them as a result of this project. The Triga reactor of Mexico does not have both of them, therefore, it was decided the need of having both system. The paper describe first the way we designed and constructed a remote Visual Inspection System and example of how is operated. Along the experience and problems we have had with the system. Also we will present the design of the Sipping system were two option were considered. First to take a sample of water after a convenient period of time passing through a circuit to a multichannel analyzer and to identify leakage by way of measuring Caesium-137. Second, exists the possibility that the Stainless Steel sleeve of the fuel has only very small failures, so it is going to be very difficult to have leakages unless the fuel is hot. Therefore we are evaluating the possibility of using heaters to increase the temperature of the fuel and succeed on detecting leakages. The results - we hope - will be ready to be presented at the meeting. (author)

  18. Dry Sliding Wear Behavior of A356 Alloy/Mg2Sip Functionally Graded in-situ Composites: Effect of Processing Conditions

    Directory of Open Access Journals (Sweden)

    S.C. Ram

    2016-09-01

    Full Text Available In present study, the effect of dry sliding wear conditions of A356 alloy/Mg2Sip functionally graded in-situ composites developed by centrifugal casting method has been studied. A pure commercial A356 alloy (Al–7.5Si–0.3Mg was selected to be the matrix of the composites and primary Mg2Sip reinforcing particles were formed by in-situ chemical reaction with an average grain size of 40-47.8 µm. The Al–(Mg2Sip functionally graded metal matrix composites (FGMMC’s were synthesized by centrifugal casting technique with radial geometry, using two different mould rotating speeds ( 1200 and 1600 rpm. The X-ray diffraction (XRD characterization technique was carried out to confirm the in-situ formed Mg2Si particles in composites. Optical microscopy examination was carried out to reveals the grain refinement of Al-rich grains due to in-situ formed Mg2Si particles. Scanning electron microscope (SEM and Energy dispersive X-ray spectroscopy (EDS techniques were carried out to reveal the distribution of phases, morphological characteristics and confirmation of primary Mg2Si particles in the matrix. The sliding wear behavior was studied using a Pin-on-Disc set-up machine with sliding wear parameters: effect of loads (N, effect of sliding distances (m and effect of Mg on wear at room temperature with a high-carbon chromium steel disc (HRC-64 as counter surfaces. A good correlation was evidenced between the dry sliding behaviour of functionally graded in-situ composites and the distribution of Mg2Si reinforcing particles. Beside the above processing conditions, the dominant wear mechanisms of functionally graded in-situ composites have been correlated with the microstructures. The hardness and wear resistance properties of these composites increase with increasing volume percent of reinforced primary Si/Mg2Si particles toward inner zone of cast cylindrical shapes. The objective of this works was to study the tribological characteristics under dry sliding

  19. A General Purpose Connections type CTI Server Based on SIP Protocol and Its Implementation

    Science.gov (United States)

    Watanabe, Toru; Koizumi, Hisao

    In this paper, we propose a general purpose connections type CTI (Computer Telephony Integration) server that provides various CTI services such as voice logging where the CTI server communicates with IP-PBX using the SIP (Session Initiation Protocol), and accumulates voice packets of external line telephone call flowing between an IP telephone for extension and a VoIP gateway connected to outside line networks. The CTI server realizes CTI services such as voice logging, telephone conference, or IVR (interactive voice response) with accumulating and processing voice packets sampled. Furthermore, the CTI server incorporates a web server function which can provide various CTI services such as a Web telephone directory via a Web browser to PCs, cellular telephones or smart-phones in mobile environments.

  20. Pre-Columbian alloys from the royal tombs of Sipán; energy dispersive X-ray fluorescence analysis with a portable equipment.

    Science.gov (United States)

    Cesareo, R; Calza, C; Dos Anjos, M; Lopes, R T; Bustamante, A; Fabian S, J; Alva, W; Chero Z, L

    2010-01-01

    On the north coast of present-day Peru flourished approximately between 50 and 700 AD, the Moche civilization. It was an advanced culture and the Moche were sophisticated metalsmiths, so that they are considered as the finest producers of jewels and artefacts of the region. The Moche metalworking ability was impressively demonstrated by the objects discovered by Walter Alva and coworkers in 1987, in the excavations of the "Tumbas Reales de Sipán". About 50 metal objects from these excavations, now at the namesake Museum, in Lambayeque, north of Peru, were analyzed with a portable equipment using energy-dispersive X-ray fluorescence. This portable equipment is mainly composed of a small size X-ray tube and a thermoelectrically cooled X-ray detector. Standard samples of gold and silver alloys were employed for quantitative analysis. It was determined that the analyzed artefacts from the "Tumbas Reales de Sipán" are mainly composed of gold, silver and copper alloys, of gilded copper and of tumbaga, the last being a poor gold alloy enriched at the surface by depletion gilding, i.e. removing copper from the surface. Copyright 2009 Elsevier Ltd. All rights reserved.

  1. Impact of mismatched and misaligned laser light sheet profiles on PIV performance

    Science.gov (United States)

    Grayson, K.; de Silva, C. M.; Hutchins, N.; Marusic, I.

    2018-01-01

    The effect of mismatched or misaligned laser light sheet profiles on the quality of particle image velocimetry (PIV) results is considered in this study. Light sheet profiles with differing widths, shapes, or alignment can reduce the correlation between PIV images and increase experimental errors. Systematic PIV simulations isolate these behaviours to assess the sensitivity and implications of light sheet mismatch on measurements. The simulations in this work use flow fields from a turbulent boundary layer; however, the behaviours and impacts of laser profile mismatch are highly relevant to any fluid flow or PIV application. Experimental measurements from a turbulent boundary layer facility are incorporated, as well as additional simulations matched to experimental image characteristics, to validate the synthetic image analysis. Experimental laser profiles are captured using a modular laser profiling camera, designed to quantify the distribution of laser light sheet intensities and inform any corrective adjustments to an experimental configuration. Results suggest that an offset of just 1.35 standard deviations in the Gaussian light sheet intensity distributions can cause a 40% reduction in the average correlation coefficient and a 45% increase in spurious vectors. Errors in measured flow statistics are also amplified when two successive laser profiles are no longer well matched in alignment or intensity distribution. Consequently, an awareness of how laser light sheet overlap influences PIV results can guide faster setup of an experiment, as well as achieve superior experimental measurements.

  2. Independent sailing with high tetraplegia using sip and puff controls: integration into a community sailing center.

    Science.gov (United States)

    Rojhani, Solomon; Stiens, Steven A; Recio, Albert C

    2017-07-01

    We are continually rediscovering how adapted recreational activity complements the rehabilitation process, enriches patients' lives and positively impacts outcome measures. Although sports for people with spinal cord injuries (SCI) has achieved spectacular visibility, participation by high cervical injuries is often restricted due to poor accessibility, safety concerns, lack of adaptability, and high costs of technology. We endeavor to demonstrate the mechanisms, adaptability, accessibility, and benefits the sport of sailing creates in the rehabilitative process. Our sailor is a 27-year-old man with a history of traumatic SCI resulting in C4 complete tetraplegia. The participant completed an adapted introductory sailing course, and instruction on the sip-and-puff sail and tiller control mechanism. With practice, he navigated an on-water course in moderate winds of 5 to 15 knots. Despite trends toward shorter rehabilitation stays, aggressive transdisciplinary collaboration with recreation therapy can provide community and natural environment experiences while inpatient and continuing post discharge. Such peak physical and psychological experiences provide a positive perspective for the future that can be shared on the inpatient unit, with families and support systems like sailing clubs in the community. Rehabilitation theory directs a team process to achieve patient self-awareness and initiate self-actualization in spite of disablement. Utilization of local community sailing centers that have provided accessible assisted options provides person-centered self-realization of goals as assisted by family and natural supports. Such successful patients become native guides for others seeking the same experience.

  3. Genome-Wide Characterization of Major Intrinsic Proteins in Four Grass Plants and Their Non-Aqua Transport Selectivity Profiles with Comparative Perspective.

    Directory of Open Access Journals (Sweden)

    Abul Kalam Azad

    Full Text Available Major intrinsic proteins (MIPs, commonly known as aquaporins, transport not only water in plants but also other substrates of physiological significance and heavy metals. In most of the higher plants, MIPs are divided into five subfamilies (PIPs, TIPs, NIPs, SIPs and XIPs. Herein, we identified 68, 42, 38 and 28 full-length MIPs, respectively in the genomes of four monocot grass plants, specifically Panicum virgatum, Setaria italica, Sorghum bicolor and Brachypodium distachyon. Phylogenetic analysis showed that the grass plants had only four MIP subfamilies including PIPs, TIPs, NIPs and SIPs without XIPs. Based on structural analysis of the homology models and comparing the primary selectivity-related motifs [two NPA regions, aromatic/arginine (ar/R selectivity filter and Froger's positions (FPs] of all plant MIPs that have been experimentally proven to transport non-aqua substrates, we predicted the transport profiles of all MIPs in the four grass plants and also in eight other plants. Groups of MIP subfamilies based on ar/R selectivity filter and FPs were linked to the non-aqua transport profiles. We further deciphered the substrate selectivity profiles of the MIPs in the four grass plants and compared them with their counterparts in rice, maize, soybean, poplar, cotton, Arabidopsis thaliana, Physcomitrella patens and Selaginella moellendorffii. In addition to two NPA regions, ar/R filter and FPs, certain residues, especially in loops B and C, contribute to the functional distinctiveness of MIP groups. Expression analysis of transcripts in different organs indicated that non-aqua transport was related to expression of MIPs since most of the unexpressed MIPs were not predicted to facilitate the transport of non-aqua molecules. Among all MIPs in every plant, TIP (BdTIP1;1, SiTIP1;2, SbTIP2;1 and PvTIP1;2 had the overall highest mean expression. Our study generates significant information for understanding the diversity, evolution, non

  4. I-TNT: PHONE NUMBER EXPANSION AND TRANSLATION SYSTEM FOR MANAGING INTERCONNECTIVITY ADDRESSING IN SIP PEERING

    Directory of Open Access Journals (Sweden)

    A. A. KHUDHER

    2015-02-01

    Full Text Available Voice over IP (VoIP subscribers is growing vastly in the recent years due to the ever increase in smartphones, 3G, WiFi, etc. This growth leads the VoIP service providers to peer with each other through Session Initiation Protocol (SIP peering for low/free cost of voice communication. Naturally, this growth is not without challenges, especially in phone addressing. This paper proposes an I-TNT (Infrastructure-Phone Number Translation numbering system to expand the range of the existing E.164 numbers and mapping between private and public number at the edge of the signalling path. As a result, I-TNT numbering system is successfully implemented and able to allocate the expanded phone numbers to end-users in one service provider.

  5. Measuring the impact of health problems among adults with limited mobility in Thailand: further validation of the Perceived Impact of Problem Profile

    Directory of Open Access Journals (Sweden)

    Manderson Lenore

    2008-01-01

    Full Text Available Abstract Background The Perceived Impact of Problem Profile (PIPP was developed to provide a tool for measuring the impact of a health condition from the individual's perspective, using the ICF model as a framework. One of the aims of the ICF is to enable the comparison of data across countries, however, relatively little is known about the subjective experience of disability in middle and low-income countries. The aim of this study was to assess the validity of the Perceived Impact of Problem Profile (PIPP for use among adults with a disability in Thailand using Rasch analysis. Methods A total of 210 adults with mobility impairment from the urban, rural and remote areas of northeast Thailand completed the PIPP, which contains 23 items assessing both impact and distress across five key domains (Self-care, Mobility, Participation, Relationships, and Psychological Well-being. Rasch analysis, using RUMM2020, was conducted to assess the internal validity and psychometric properties of the PIPP Impact subscales. Validation of the PIPP Impact scales was conducted by comparing scores across the different response levels of the EQ5D items. Results Rasch analysis indicated that participants did not clearly differentiate between 'impact' and 'distress,' the two aspects assessed by the PIPP. Further analyses were therefore limited to the PIPP Impact subscales. These showed adequate psychometric properties, demonstrating fit to the Rasch model and good person separation reliability. Preliminary validity testing using the EQ5D items provided support for the PIPP Impact subscales. Conclusion The results provide further support for the psychometric properties of the PIPP Impact scales and indicate that it is a suitable tool for use among adults with a locomotor disability in Thailand. Further research is needed to validate the PIPP across different cultural contexts and health conditions and to assess the usefulness of separate Impact and Distress subscales.

  6. Measuring the impact of health problems among adults with limited mobility in Thailand: further validation of the Perceived Impact of Problem Profile

    Science.gov (United States)

    Misajon, RoseAnne; Pallant, Julie F; Manderson, Lenore; Chirawatkul, Siriporn

    2008-01-01

    Background The Perceived Impact of Problem Profile (PIPP) was developed to provide a tool for measuring the impact of a health condition from the individual's perspective, using the ICF model as a framework. One of the aims of the ICF is to enable the comparison of data across countries, however, relatively little is known about the subjective experience of disability in middle and low-income countries. The aim of this study was to assess the validity of the Perceived Impact of Problem Profile (PIPP) for use among adults with a disability in Thailand using Rasch analysis. Methods A total of 210 adults with mobility impairment from the urban, rural and remote areas of northeast Thailand completed the PIPP, which contains 23 items assessing both impact and distress across five key domains (Self-care, Mobility, Participation, Relationships, and Psychological Well-being). Rasch analysis, using RUMM2020, was conducted to assess the internal validity and psychometric properties of the PIPP Impact subscales. Validation of the PIPP Impact scales was conducted by comparing scores across the different response levels of the EQ5D items. Results Rasch analysis indicated that participants did not clearly differentiate between 'impact' and 'distress,' the two aspects assessed by the PIPP. Further analyses were therefore limited to the PIPP Impact subscales. These showed adequate psychometric properties, demonstrating fit to the Rasch model and good person separation reliability. Preliminary validity testing using the EQ5D items provided support for the PIPP Impact subscales. Conclusion The results provide further support for the psychometric properties of the PIPP Impact scales and indicate that it is a suitable tool for use among adults with a locomotor disability in Thailand. Further research is needed to validate the PIPP across different cultural contexts and health conditions and to assess the usefulness of separate Impact and Distress subscales. PMID:18208616

  7. Application of RNA Stable Isotope Probing (SIP) to Link Community Activity with Microorganisms Responsible for Autotrophy in the Subseafloor at Axial Seamount

    Science.gov (United States)

    Huber, J. A.; Fortunato, C. S.

    2014-12-01

    The global ocean comprises the Earth's largest biome, with microorganisms playing a dominant biogeochemical role. However, the potential for production of new microbial biomass within the subseafloor is rarely considered in traditional oceanographic paradigms of carbon cycling or microbial food webs. In this study, we used RNA Stable Isotope Probing (RNA SIP) to determine the microbial community composition and genetic repertoire of active subseafloor autotrophs in warm venting fluids from Axial Seamount. RNA is a responsive biomarker because it is a reflection of cellular activity independent of replication, and RNA SIP thus provides access to both the function of a microbial community and the phylogeny of the organisms accountable for key functions. Diffuse fluids were incubated shipboard at 30°C, 55°C, and 80°C with 13DIC and H2. Metatranscriptomic sequencing of both the enriched and non-enriched RNA was carried out from 13C and 12C controls. In addition, filtered fluid samples were preserved in situ for comparative meta -transcriptomic and -genomic analyses. Diverse lineages of bacteria and archaea and accompanying metabolisms were detected in situ, but RNA SIP results show dominance of three different groups of autotrophs active under each experimental condition. At 30°C, members of the Sulfurimonas genus dominated, with genes for hydrogen oxidation, nitrate reduction, and carbon fixation via the rTCA cycle highly expressed. At 55°C, both Caminibacter and Nautilia transcripts were detected for rTCA cycle, hydrogen oxidation, and nitrate reduction. At 80°C, transcripts for hydrogenotrophic methanogenesis mediated by members of Methanocaldococcus were detected. These results suggest the subseafloor hosts various anaerobic chemolithoautotrophs that span a wide temperature range, with hydrogen playing a key role in microbial metabolism. Complementary experiments are currently being carried out on the seafloor with a novel in situ incubator unit to provide

  8. Impact of axial burnup profile on criticality safety of ANPP spent fuel cask

    International Nuclear Information System (INIS)

    Bznuni, S.

    2006-01-01

    Criticality safety assessment for WWER-440 NUHOMS cask with spent nuclear fuel from Armenian NPP has been performed. The cask was designed in such way that the neutron multiplication factor k eff must be below 0,95 for all operational modes and accident conditions. Usually for criticality analysis, fresh fuel approach with the highest enrichment is taken as conservative assumption as it was done for ANPP. NRSC ANRA in order to improve future fuel storage efficiency initiated research with taking into account burn up credit in the criticality safety assessment. Axial burn up profile (end effect) has essential impact on criticality safety justification analysis. However this phenomenon was not taken into account in the Safety Analysis Report of NUHOMS spent fuel storage constructed on the site of ANPP. Although ANRA does not yet accept burn up credit approach for ANPP spent fuel storage, assessment of impact of axial burnup profile on criticality of spent fuel assemblies has important value for future activities of ANRA. This paper presents results of criticality calculations of spent fuel assemblies with axial burn up profile. Horizontal burn up profile isn't taken account since influence of the horizontal variation of the burn up is much less than the axial variation. The actinides and actinides + fission products approach are discussed. The calculations were carried out with STARBUCS module of SCALE 5.0 code package developed at Oak Ridge National laboratory. SCALE5.0 sequence CSAS26 (KENO-VI) was used for evaluation the k eff for 3-D problems. Obtained results showed that criticality of ANPP spent fuel cask is very sensitive to the end effect

  9. The Impact of Hospital Size on CMS Hospital Profiling.

    Science.gov (United States)

    Sosunov, Eugene A; Egorova, Natalia N; Lin, Hung-Mo; McCardle, Ken; Sharma, Vansh; Gelijns, Annetine C; Moskowitz, Alan J

    2016-04-01

    The Centers for Medicare & Medicaid Services (CMS) profile hospitals using a set of 30-day risk-standardized mortality and readmission rates as a basis for public reporting. These measures are affected by hospital patient volume, raising concerns about uniformity of standards applied to providers with different volumes. To quantitatively determine whether CMS uniformly profile hospitals that have equal performance levels but different volumes. Retrospective analysis of patient-level and hospital-level data using hierarchical logistic regression models with hospital random effects. Simulation of samples including a subset of hospitals with different volumes but equal poor performance (hospital effects=+3 SD in random-effect logistic model). A total of 1,085,568 Medicare fee-for-service patients undergoing 1,494,993 heart failure admissions in 4930 hospitals between July 1, 2005 and June 30, 2008. CMS methodology was used to determine the rank and proportion (by volume) of hospitals reported to perform "Worse than US National Rate." Percent of hospitals performing "Worse than US National Rate" was ∼40 times higher in the largest (fifth quintile by volume) compared with the smallest hospitals (first quintile). A similar gradient was seen in a cohort of 100 hospitals with simulated equal poor performance (0%, 0%, 5%, 20%, and 85% in quintiles 1 to 5) effectively leaving 78% of poor performers undetected. Our results illustrate the disparity of impact that the current CMS method of hospital profiling has on hospitals with higher volumes, translating into lower thresholds for detection and reporting of poor performance.

  10. IMPACT web portal: oncology database integrating molecular profiles with actionable therapeutics.

    Science.gov (United States)

    Hintzsche, Jennifer D; Yoo, Minjae; Kim, Jihye; Amato, Carol M; Robinson, William A; Tan, Aik Choon

    2018-04-20

    With the advancement of next generation sequencing technology, researchers are now able to identify important variants and structural changes in DNA and RNA in cancer patient samples. With this information, we can now correlate specific variants and/or structural changes with actionable therapeutics known to inhibit these variants. We introduce the creation of the IMPACT Web Portal, a new online resource that connects molecular profiles of tumors to approved drugs, investigational therapeutics and pharmacogenetics associated drugs. IMPACT Web Portal contains a total of 776 drugs connected to 1326 target genes and 435 target variants, fusion, and copy number alterations. The online IMPACT Web Portal allows users to search for various genetic alterations and connects them to three levels of actionable therapeutics. The results are categorized into 3 levels: Level 1 contains approved drugs separated into two groups; Level 1A contains approved drugs with variant specific information while Level 1B contains approved drugs with gene level information. Level 2 contains drugs currently in oncology clinical trials. Level 3 provides pharmacogenetic associations between approved drugs and genes. IMPACT Web Portal allows for sequencing data to be linked to actionable therapeutics for translational and drug repurposing research. The IMPACT Web Portal online resource allows users to query genes and variants to approved and investigational drugs. We envision that this resource will be a valuable database for personalized medicine and drug repurposing. IMPACT Web Portal is freely available for non-commercial use at http://tanlab.ucdenver.edu/IMPACT .

  11. Direct measurements of air layer profiles under impacting droplets using high-speed color interferometry

    NARCIS (Netherlands)

    van der Veen, Roeland; Tran, Tuan; Lohse, Detlef; Sun, Chao

    2012-01-01

    A drop impacting on a solid surface deforms before the liquid makes contact with the surface. We directly measure the time evolution of the air layer profile under the droplet using high-speed color interferometry, obtaining the air layer thickness before and during the wetting process. Based on the

  12. Arsenate impact on the metabolite profile, production and arsenic loading of xylem sap in cucumbers (Cucumis sativus L.

    Directory of Open Access Journals (Sweden)

    Kalle eUroic

    2012-04-01

    Full Text Available Arsenic uptake and translocation studies on xylem sap focus generally on the concentration and speciation of arsenic in the xylem. Arsenic impact on the xylem sap metabolite profile and its production during short term exposure has not been reported in detail. To investigate this, cucumbers were grown hydroponically and arsenate (AsV and DMA were used for plant treatment for 24 h. Total arsenic and arsenic speciation in xylem sap was analysed including a metabolite profiling under arsenate stress. Produced xylem sap was quantified and absolute arsenic transported was determined. AsV exposure has a significant impact on the metabolite profile of xylem sap. Four m/z values corresponding to four compounds were up regulated, one compound down regulated by arsenate exposure. The compound down regulated was identified to be isoleucine. Furthermore, arsenate has a significant influence on sap production, leading to a reduction of up to 96 % sap production when plants are exposed to 1000 μg kg-1 arsenate. No difference to control plants was observed when plants were exposed to 1000 μg kg-1 DMA. Absolute arsenic amount in xylem sap was the lowest at high arsenate exposure. These results show that AsV has a significant impact on the production and metabolite profile of xylem sap. The physiological importance of isoleucine needs further attention.

  13. Arsenate Impact on the Metabolite Profile, Production, and Arsenic Loading of Xylem Sap in Cucumbers (Cucumis sativus L.)

    Science.gov (United States)

    Uroic, M. Kalle; Salaün, Pascal; Raab, Andrea; Feldmann, Jörg

    2012-01-01

    Arsenic uptake and translocation studies on xylem sap focus generally on the concentration and speciation of arsenic in the xylem. Arsenic impact on the xylem sap metabolite profile and its production during short term exposure has not been reported in detail. To investigate this, cucumbers were grown hydroponically and arsenate (AsV) and DMA were used for plant treatment for 24 h. Total arsenic and arsenic speciation in xylem sap was analyzed including a metabolite profiling under AsV stress. Produced xylem sap was quantified and absolute arsenic transported was determined. AsV exposure had a significant impact on the metabolite profile of xylem sap. Four m/z values corresponding to four compounds were up-regulated, one compound down-regulated by AsV exposure. The compound down-regulated was identified to be isoleucine. Furthermore, AsV exposure had a significant influence on sap production, leading to a reduction of up to 96% sap production when plants were exposed to 1000 μg kg−1 AsV. No difference to control plants was observed when plants were exposed to 1000 μg kg−1 DMA. Absolute arsenic amount in xylem sap was the lowest at high AsV exposure. These results show that AsV has a significant impact on the production and metabolite profile of xylem sap. The physiological importance of isoleucine needs further attention. PMID:22536187

  14. Double crystal X-ray analysis of phosphorus precipitation in supersaturated Si-P solid solutions

    International Nuclear Information System (INIS)

    Servidori, M.; Zini, Q.; Dal Monte, C.

    1983-01-01

    The physical nature of the electrically inactive phosphorus in silicon is investigated by double crystal X-ray diffraction measurements. This analysis is performed on laser annealed supersaturated samples, doped by ion implantation up to 5 x 10 21 cm -3 . After isothermal heat treatments, these solid solutions show marked reductions in the electrically active phosphorus concentration. In particular, 850 0 C heatings give rise to a carrier concentration which corresponds to the phosphorus solubility in equilibrium with the inactive dopant. This dopant is characterized by means of lattice strain measurements: they are found consistent with the presence of perfectly coherent cubic SiP precipitates. This result is in agreement with the one obtained in preceeding works by electrical measurements and transmission electron microscopy observations and contradicts the hypothesis that the excess dopant atoms are, at least in part, charged point defects (E-centres). (author)

  15. Impact of instrumental response on observed ozonesonde profiles: First-order estimates and implications for measures of variability

    Science.gov (United States)

    Clifton, G. T.; Merrill, J. T.; Johnson, B. J.; Oltmans, S. J.

    2009-12-01

    Ozonesondes provide information on the ozone distribution up to the middle stratosphere. Ozone profiles often feature layers, with vertically discrete maxima and minima in the mixing ratio. Layers are especially common in the UT/LS regions and originate from wave breaking, shearing and other transport processes. ECC sondes, however, have a moderate response time to significant changes in ozone. A sonde can ascend over 350 meters before it responds fully to a step change in ozone. This results in an overestimate of the altitude assigned to layers and an underestimate of the underlying variability in the amount of ozone. An estimate of the response time is made for each instrument during the preparation for flight, but the profile data are typically not processed to account for the response. Here we present a method of categorizing the response time of ECC instruments and an analysis of a low-pass filter approximation to the effects on profile data. Exponential functions were fit to the step-up and step-down responses using laboratory data. The resulting response time estimates were consistent with results from standard procedures, with the up-step response time exceeding the down-step value somewhat. A single-pole Butterworth filter that approximates the instrumental effect was used with synthetic layered profiles to make first-order estimates of the impact of the finite response time. Using a layer analysis program previously applied to observed profiles we find that instrumental effects can attenuate ozone variability by 20-45% in individual layers, but that the vertical offset in layer altitudes is moderate, up to about 150 meters. We will present results obtained using this approach, coupled with data on the distribution of layer characteristics found using the layer analysis procedure on profiles from Narragansett, Rhode Island and other US sites to quantify the impact on overall variability estimates given ambient distributions of layer occurrence, thickness

  16. Study of temperature distribution of pipes heated by moving rectangular gauss distribution heat source. Development of pipe outer surface irradiated laser stress improvement process (L-SIP)

    International Nuclear Information System (INIS)

    Ohta, Takahiro; Kamo, Kazuhiko; Asada, Seiji; Terasaki, Toshio

    2009-01-01

    The new process called L-SIP (outer surface irradiated Laser Stress Improvement Process) is developed to improve the tensile residual stress of the inner surface near the butt welded joints of pipes in the compression stress. The temperature gradient occurs in the thickness of pipes in heating the outer surface rapidly by laser beam. By the thermal expansion difference between the inner surface and the outer surface, the compression stress occurs near the inner surface of pipes. In this paper, the theoretical equation for the temperature distributions of pipes heated by moving rectangular Gauss distribution heat source on the outer surface is derived. The temperature histories of pipes calculated by theoretical equation agree well with FEM analysis results. According to the theoretical equation, the controlling parameters of temperature distributions and histories are q/2a y , vh, a x /h and a y /h, where q is total heat input, a y is heat source length in the axial direction, a x is Gaussian radius of heat source in the hoop direction, ν is moving velocity, and h is thickness of the pipe. The essential variables for L-SIP, which are defined on the basis of the measured temperature histories on the outer surface of the pipe, are Tmax, F 0 =kτ 0 /h 2 , vh, W Q and L Q , where Tmax is maximum temperature on the monitor point of the outer surface, k is thermal diffusivity coefficient, τ 0 is the temperature rise time from 100degC to maximum temperature on the monitor point of the outer surface, W Q is τ 0 x ν, and L Q is the uniform temperature length in the axial direction. It is verified that the essential variables for L-SIP match the controlling parameters by the theoretical equation. (author)

  17. The moderating impact of childhood adversity profiles and conflict on psychological health and suicidal behaviour in the Northern Ireland population.

    Science.gov (United States)

    McLafferty, Margaret; O'Neill, Siobhan; Murphy, Sam; Armour, Cherie; Ferry, Finola; Bunting, Brendan

    2018-04-01

    Childhood adversities are key etiological factors in the onset and persistence of psychopathology. In Northern Ireland the Troubles also impacted on the population's psychological health. This study used data from the Northern Ireland Study of Health and Stress a collaborative epidemiological study which used the WMH-CIDI to assess mental health disorders in a nationally representative sample (Part 2, n = 1986). The aims of the study were to assess co-occurrences of childhood adversities and investigate the impact of adversity profiles and conflict experience on psychopathology and suicidal behaviour. Latent Class Analysis uncovered 3 discrete childhood adversity profiles, a low, medium, and high risk class. Individuals from higher risk adversity profiles displayed significantly increased odds of having psychological problems, with conflict exposure also impacting on psychopathology. However, the study revealed that the impact of conflict exposure on suicidal behaviour was moderated by latent class membership and that some adversity may actually be protective. The findings highlight the need to consider that, while adversity can have a negative impact on psychopathology, a lack of adversity early in life may hinder some people from developing adequate coping strategies. Further research is required to identify adversity patterns and other interacting factors that are protective. Copyright © 2018 Elsevier B.V. All rights reserved.

  18. The impact of shape memory test on degradation profile of a bioresorbable polymer.

    Science.gov (United States)

    Musioł, Marta; Jurczyk, Sebastian; Kwiecień, Michał; Smola-Dmochowska, Anna; Domański, Marian; Janeczek, Henryk; Włodarczyk, Jakub; Klim, Magdalena; Rydz, Joanna; Kawalec, Michał; Sobota, Michał

    2018-05-01

    The semicrystalline poly(L-lactide) (PLLA) belongs to the materials with shape memory effect (SME) and as a bioresorbable and biocompatible polymer it have found many applications in medical and pharmaceutical field. Assessment of the SME impact on the polymer degradation profile plays crucial role in applications such as drug release systems or in regenerative medicine. Herein, the results of in vitro degradation studies of PLLA samples after SME full test cycle are presented. The samples were loaded and deformed in two manners: progressive and non-progressive. The performed experiments illustrate also influence of the material mechanical damages, caused e.g. during incorrect implantation of PLLA product, on hydrolytic degradation profile. Apparently, degradation profiles are significantly different for the material which was not subjected to the deformation and the deformed ones. The materials after deformation of 50% (in SME cycle) was characterized by non-reversible morphology changes. The effect was observed in deformed samples during the SME test which were carried out ten times. Copyright © 2018 Elsevier Ltd. All rights reserved.

  19. Geophysical exploration of historical mine dumps for the estimation of valuable residuals

    Science.gov (United States)

    Martin, Tina; Knieß, Rudolf; Noell, Ursula; Hupfer, Sarah; Kuhn, Kerstin; Günther, Thomas

    2015-04-01

    Within the project ROBEHA, funded by the German Federal Ministry of Education and Research (033R105) the economic potential of different abandoned dump sites for mine waste in the Harz Mountains was investigated. Two different mining dumps were geophysically and mineralogically analysed in order to characterize the mine dump structure and to estimate the volume of the potential recycling material. The geophysical methods comprised geoelectrics, radar, and spectral induced polarization (SIP). One about 100-year old mining dump containing residues from density separated Ag- and Sb-rich Pb (Zn)-gangue ores was investigated in detail. Like most small-scale mining waste disposal sites this investigated dump is very heterogeneously structured. Therefore, 27 geoelectrical profiles, more than 50 radar profiles, and several SIP profiles were measured and analysed. The results from the radar measurements, registered with the GSSI system and a shielded 200 MHz antenna, show the near surface boundary layer (down to 3-4 m beneath surface) of the waste residuals. These results can be used as pre-information for the inversion process of the geoelectrical data. The geoelectrical results reveal the mineral residues as layers with higher resistivities (> 300 Ohm*m) than the surrounding material. The SIP method found low phase signals (mine dump and other parameters we get a first estimate for the volume of the residues but the economical viability and the environmental impact of the reworking of the dump still needs to be evaluated in detail. The results of the second mine dump, an abandoned Cu and Zn-rich slag heap, show that the slag residues are characterized by higher resistivities and higher phases. A localization of the slag residues which are covered by organic material could be realized applying these geophysical methods.

  20. Adaptation and content validity by expert judgment of the Oral Health Impact Profile applied to Periodontal Disease.

    Directory of Open Access Journals (Sweden)

    Norma Idalia Rodríguez

    2017-04-01

    Full Text Available Background: In Mexico, there is no available instrument based on a biopsychosocial model to evaluate the impact of periodontal disease on oral health-related quality of life (OHRQL. The Oral Health Impact Profile (OHIP-14 was developed in Australia and the United States based on the same model and can be adapted to evaluate the impact of periodontal disease on OHRQL. Objectives: To adapt the OHIP-14 questions to periodontal disease evaluation and validate the content of this new instrument. Materials and Methods: One expert in periodontics and one expert in health psychology adapted the OHIP-14 to evaluate the impact of periodontal disease on OHRQL, creating the Oral Health Impact Profile applied to Periodontal Disease (OHIP-14-PD. Using the format proposed by Escobar and Cuervo, five experts in periodontics and public health performed the OHIP-14-PD content validation. Results: Item 7 had a compliance rate of 80% for clarity, and the other items, a compliance rate of 100%, for clarity, sufficiency, coherence and relevance. The kappa coefficient showed perfect agreement for items 1 to 6 (k= 1 and 8 to 14, and very high agreement for item 7 (k= 0.967. Conclusion: The OHIP-14-PD shows content validity.

  1. 76 FR 78968 - Environmental Impact Statement: Cook and DuPage Counties, IL

    Science.gov (United States)

    2011-12-20

    ... further detail on the alternatives for the preferred transportation system concept that resulted from the... facilities. The Tier One Stakeholder Involvement Plan (SIP), which met the SAFETEA-LU Coordination Plan... identified and addressed. The SIP provides meaningful opportunities for all stakeholders to participate in...

  2. Cross-cultural equivalence in translations of the oral health impact profile.

    Science.gov (United States)

    MacEntee, Michael I; Brondani, Mario

    2016-04-01

    The Oral Health Impact Profile (OHIP) has been translated for comparisons across cultural boundaries. This report on a systematic search of literature published between 1994 and 2014 aims to identify an acceptable method of translating psychometric instruments for cross-cultural equivalence, and how they were used to translate the OHIP. An electronic search used the keywords 'cultural adaptation', 'validation', 'Oral Health Impact Profile' and 'OHIP' in MEDLINE and EMBASE databases supplemented by reference links and grey literature. It included papers on methods of cross-cultural translation and translations of the OHIP for dentulous adults and adolescents, and excluded papers without translational details or limited to specific disorders. The search identified eight steps to cross-cultural equivalence, and 36 (plus three supplemental) translations of the OHIP. The steps involve assessment of (i) forward/backward translation by committee, (ii) constructs, (iii) item interpretations, (iv) interval scales, (v) convergent validity, (vi) discriminant validity, (vii) responsiveness to clinical change and (viii) pilot tests. Most (>60%) of the translations involved forward/backward translation by committee, item interpretations, interval scales, convergence, discrimination and pilot tests, but fewer assessed the underlying theory (47%) or responsiveness to clinical change (28%). An acceptable method for translating quality of life-related psychometric instruments for cross-cultural equivalence has eight procedural steps, and most of the 36 OHIP translations involved at least five of the steps. Only translations to Saudi Arabian Arabic, Chinese Mandarin, German and Japanese used all eight steps to claim cultural equivalence with the original OHIP. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  3. Sipping test update device for fuel elements cladding inspections in IPR-r1 TRIGA reactor

    Energy Technology Data Exchange (ETDEWEB)

    Rodrigues, R.R.; Mesquita, A.Z.; Andrade, E.P.D.; Gual, Maritza R., E-mail: rrr@cdtn.br, E-mail: amir@cdtn.br, E-mail: edson@cdtn.br, E-mail: maritzargual@gmail.com [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)

    2015-07-01

    It is in progress at the Centro de Desenvolvimento da Tecnologia Nuclear - CDTN (Nuclear Technology Development Center), a research project that aims to investigate possible leaks in the fuel elements of the TRIGA reactor, located in this research center. This paper presents the final form of sipping test device for TRIGA reactor, and results of the first experiments setup. Mechanical support strength tests were made by knotting device on the crane, charged with water from the conventional water supply, and tests outside the reactor pool with the use of new non-irradiated fuel elements encapsulated in stainless steel, and available safe stored in this unit. It is expected that tests with graphite elements from reactor pool are done soon after and also the test experiment with the first fuel elements in service positioned in the B ring (central ring) of the reactor core in the coming months. (author)

  4. Sipping test update device for fuel elements cladding inspections in IPR-r1 TRIGA reactor

    International Nuclear Information System (INIS)

    Rodrigues, R.R.; Mesquita, A.Z.; Andrade, E.P.D.; Gual, Maritza R.

    2015-01-01

    It is in progress at the Centro de Desenvolvimento da Tecnologia Nuclear - CDTN (Nuclear Technology Development Center), a research project that aims to investigate possible leaks in the fuel elements of the TRIGA reactor, located in this research center. This paper presents the final form of sipping test device for TRIGA reactor, and results of the first experiments setup. Mechanical support strength tests were made by knotting device on the crane, charged with water from the conventional water supply, and tests outside the reactor pool with the use of new non-irradiated fuel elements encapsulated in stainless steel, and available safe stored in this unit. It is expected that tests with graphite elements from reactor pool are done soon after and also the test experiment with the first fuel elements in service positioned in the B ring (central ring) of the reactor core in the coming months. (author)

  5. Impact of intermittent fasting on the lipid profile: Assessment associated with diet and weight loss.

    Science.gov (United States)

    Santos, Heitor O; Macedo, Rodrigo C O

    2018-04-01

    Intermittent fasting, whose proposed benefits include the improvement of lipid profile and the body weight loss, has gained considerable scientific and popular repercussion. This review aimed to consolidate studies that analyzed the lipid profile in humans before and after intermittent fasting period through a detailed review; and to propose the physiological mechanism, considering the diet and the body weight loss. Normocaloric and hypocaloric intermittent fasting may be a dietary method to aid in the improvement of the lipid profile in healthy, obese and dyslipidemic men and women by reducing total cholesterol, LDL, triglycerides and increasing HDL levels. However, the majority of studies that analyze the intermittent fasting impacts on the lipid profile and body weight loss are observational based on Ramadan fasting, which lacks large sample and detailed information about diet. Randomized clinical trials with a larger sample size are needed to evaluate the IF effects mainly in patients with dyslipidemia. Copyright © 2018 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.

  6. Dephasing rates for weak localization and universal conductance fluctuations in two dimensional Si:P and Ge:P δ-layers.

    Science.gov (United States)

    Shamim, Saquib; Mahapatra, S; Scappucci, G; Klesse, W M; Simmons, M Y; Ghosh, Arindam

    2017-05-04

    We report quantum transport measurements on two dimensional (2D) Si:P and Ge:P δ-layers and compare the inelastic scattering rates relevant for weak localization (WL) and universal conductance fluctuations (UCF) for devices of various doping densities (0.3-2.5 × 10 18 m -2 ) at low temperatures (0.3-4.2 K). The phase breaking rate extracted experimentally from measurements of WL correction to conductivity and UCF agree well with each other within the entire temperature range. This establishes that WL and UCF, being the outcome of quantum interference phenomena, are governed by the same dephasing rate.

  7. Colorado SIP: 5 CCR 1001-13, Reg 11, Motor Vehicle Emissions Inspection Program—Part A, General Provisions, Area of Applicability, Schedules for Obtaining Certification of Emissions Control, Definitions, Exemptions, and Clean Screening/Remote Sensing

    Science.gov (United States)

    Colorado SIP: 5 CCR 1001-13, Reg 11, Motor Vehicle Emissions Inspection Program—Part A, General Provisions, Area of Applicability, Schedules for Obtaining Certification of Emissions Control, Definitions, Exemptions, and Clean Screening/Remote Sensing

  8. Validation of a multidimensional evaluation scale for use in elderly cancer patients.

    Science.gov (United States)

    Monfardini, S; Ferrucci, L; Fratino, L; del Lungo, I; Serraino, D; Zagonel, V

    1996-01-15

    Although aging is one of the most important risk factors for cancer, elderly patients tend to be excluded from cancer clinical trials, only on the basis of chronologic age. Performance Status (PS) has been used widely to select adult patients for entry into clinical trials, but it does not include a comprehensive evaluation of various age-related factors in the elderly. This study was designed to assess the reliability and validity of a multidimensional geriatric assessment protocol for elderly patients with cancer. Thirty consecutive elderly patients (> or = 65 years), diagnosed with hematologic neoplasia or solid tumors and undergoing chemotherapy or radiotherapy, were given a specifically structured multidimensional questionnaire (MACE) three times during one week by two different physicians. MACE was intended to collect information on demographics, socioeconomic status, cognitive status, depression, physical performance, disability, and tumor characteristics. In parallel with MACE, information was collected by means of the Sickness Impact Profile (SIP). Both for inter-rater and test-retest reliability, the values of the intraclass correlation coefficient (ICC) were generally higher than 0.7. Disability, cognitive status, depressive symptoms, and the number of days spent in bed sick in the last two weeks were markedly correlated with the global, physical, and social SIP score. Disability alone explained 70% of the variance in the SIP global score, 83% of the variance in the SIP physical score, and 45% of the variance in the SIP psychosocial score. MACE proved to be applicable in a reasonable amount of time (around 30 minutes) for a medical oncology ward. These data indicate that this structured evaluation of functional status is feasible and reliable. MACE is therefore proposed as a clinical research tool to avoid arbitrary decisions on patient selection for enrollment in clinical trials, to favor uniform monitoring of treatment, and to allow a better comparison

  9. Quality of life and response of negative symptoms in schizophrenia to haloperidol and the atypical antipsychotic remoxipride. The Canadian Remoxipride Group.

    Science.gov (United States)

    Awad, A G; Lapierre, Y D; Angus, C; Rylander, A

    1997-07-01

    In a large, multicenter, double-blind study of the effect of haloperidol and the atypical antipsychotic remoxipride on improvement of negative symptoms in schizophrenia, quality of life was also assessed using a modified version of the Sickness Impact Profile (SIP). Compared with previous studies, this study had a longer duration (28 weeks), and the dose of the comparator, haloperidol, was much lower. At the end of the study, compared with the baseline, both treatment groups reported comparable improvement in negative symptoms as defined by the protocol (at least 20% improvement). Similarly, both groups showed comparable changes on global and multidimensional self-assessments of quality of life. All the subfactors of the modified version of the SIP were similar in both groups, except for the subfactor that relates to alertness behavior, which possibly reflects remoxipride's lack of any sedating properties compared with haloperidol. This study presents an approach for inclusion of quality of life as an outcome measure in the design of clinical trials of new antipsychotic medications.

  10. Psychosocial impact of Parkinson's disease-associated dysarthria: Cross-cultural adaptation and validation of the Dysarthria Impact Profile into European Portuguese.

    Science.gov (United States)

    Cardoso, Rita; Guimarães, Isabel; Santos, Helena; Loureiro, Rita; Domingos, Josefa; Abreu, Daisy; Gonçalves, Nilza; Pinto, Serge; Ferreira, Joaquim J

    2018-01-26

    The present study sought to make a cross-cultural adaptation of the Dysarthria Impact Profile (DIP) for European Portuguese (EP) and validate it for use in Parkinson's disease (PD) patients. The cross-cultural adaptation was carried out in accordance with the guidelines. The EP version of the DIP was administered to 80 people with PD, and 30 sex- and age-matched control participants. Psychometric properties, acceptability, feasibility reliability (internal consistency and intrarater agreement) and validity (construct, convergent and known-groups validity) were assessed using other assessment tools (motor disability and impairment, and voice impact). Overall, the EP-DIP final version has the same conceptual meaning, semantics, idiomatic and score equivalences as the original version. Statistical analyses showed adequate feasibility (missing data psychosocial impact of slight-to-mild dysarthria in people with PD. Geriatr Gerontol Int 2018; ••: ••-••. © 2018 Japan Geriatrics Society.

  11. Determining the minimally important difference for the Oral Health Impact Profile-20.

    LENUS (Irish Health Repository)

    Allen, P Finbarr

    2009-04-01

    In the context of clinical trials, measurement of change is critical. The aim of this study was to determine the minimally important difference (MID) for the Oral Health Impact Profile-20 (OHIP-20) when used with partially dentate patients undergoing treatment that included the provision of removable partial dentures. In a prospective clinical trial, 51 consecutive patients were provided with removable partial dentures. In addition to demographic and dental status data, patients completed an OHIP-20 prior to treatment. One month postoperatively, patients completed a post-treatment OHIP-20 and a global transition scale. Domains assessed in the global transition scale were appearance, ability to chew food, oral comfort, and speech. The MID for the OHIP-20 was calculated using the anchor-based approach. From the initial sample of 51 patients, 44 completed post-treatment questionnaires and were included in the analysis. Change scores in the four transition domains indicated that new dentures had a positive impact in the majority of subjects, especially in perceived impact on chewing and appearance. The study provided a guideline as to what constitutes the MID for the OHIP-20. This benchmark can be used when interpreting the impact of clinical intervention for replacing missing teeth and for power calculation in statistical analyses.

  12. Non-Saccharomyces Yeasts Nitrogen Source Preferences: Impact on Sequential Fermentation and Wine Volatile Compounds Profile

    Directory of Open Access Journals (Sweden)

    Antoine Gobert

    2017-11-01

    Full Text Available Nitrogen sources in the must are important for yeast metabolism, growth, and performance, and wine volatile compounds profile. Yeast assimilable nitrogen (YAN deficiencies in grape must are one of the main causes of stuck and sluggish fermentation. The nitrogen requirement of Saccharomyces cerevisiae metabolism has been described in detail. However, the YAN preferences of non-Saccharomyces yeasts remain unknown despite their increasingly widespread use in winemaking. Furthermore, the impact of nitrogen consumption by non-Saccharomyces yeasts on YAN availability, alcoholic performance and volatile compounds production by S. cerevisiae in sequential fermentation has been little studied. With a view to improving the use of non-Saccharomyces yeasts in winemaking, we studied the use of amino acids and ammonium by three strains of non-Saccharomyces yeasts (Starmerella bacillaris, Metschnikowia pulcherrima, and Pichia membranifaciens in grape juice. We first determined which nitrogen sources were preferentially used by these yeasts in pure cultures at 28 and 20°C (because few data are available. We then carried out sequential fermentations at 20°C with S. cerevisiae, to assess the impact of the non-Saccharomyces yeasts on the availability of assimilable nitrogen for S. cerevisiae. Finally, 22 volatile compounds were quantified in sequential fermentation and their levels compared with those in pure cultures of S. cerevisiae. We report here, for the first time, that non-Saccharomyces yeasts have specific amino-acid consumption profiles. Histidine, methionine, threonine, and tyrosine were not consumed by S. bacillaris, aspartic acid was assimilated very slowly by M. pulcherrima, and glutamine was not assimilated by P. membranifaciens. By contrast, cysteine appeared to be a preferred nitrogen source for all non-Saccharomyces yeasts. In sequential fermentation, these specific profiles of amino-acid consumption by non-Saccharomyces yeasts may account for

  13. Non-Saccharomyces Yeasts Nitrogen Source Preferences: Impact on Sequential Fermentation and Wine Volatile Compounds Profile

    Science.gov (United States)

    Gobert, Antoine; Tourdot-Maréchal, Raphaëlle; Morge, Christophe; Sparrow, Céline; Liu, Youzhong; Quintanilla-Casas, Beatriz; Vichi, Stefania; Alexandre, Hervé

    2017-01-01

    Nitrogen sources in the must are important for yeast metabolism, growth, and performance, and wine volatile compounds profile. Yeast assimilable nitrogen (YAN) deficiencies in grape must are one of the main causes of stuck and sluggish fermentation. The nitrogen requirement of Saccharomyces cerevisiae metabolism has been described in detail. However, the YAN preferences of non-Saccharomyces yeasts remain unknown despite their increasingly widespread use in winemaking. Furthermore, the impact of nitrogen consumption by non-Saccharomyces yeasts on YAN availability, alcoholic performance and volatile compounds production by S. cerevisiae in sequential fermentation has been little studied. With a view to improving the use of non-Saccharomyces yeasts in winemaking, we studied the use of amino acids and ammonium by three strains of non-Saccharomyces yeasts (Starmerella bacillaris, Metschnikowia pulcherrima, and Pichia membranifaciens) in grape juice. We first determined which nitrogen sources were preferentially used by these yeasts in pure cultures at 28 and 20°C (because few data are available). We then carried out sequential fermentations at 20°C with S. cerevisiae, to assess the impact of the non-Saccharomyces yeasts on the availability of assimilable nitrogen for S. cerevisiae. Finally, 22 volatile compounds were quantified in sequential fermentation and their levels compared with those in pure cultures of S. cerevisiae. We report here, for the first time, that non-Saccharomyces yeasts have specific amino-acid consumption profiles. Histidine, methionine, threonine, and tyrosine were not consumed by S. bacillaris, aspartic acid was assimilated very slowly by M. pulcherrima, and glutamine was not assimilated by P. membranifaciens. By contrast, cysteine appeared to be a preferred nitrogen source for all non-Saccharomyces yeasts. In sequential fermentation, these specific profiles of amino-acid consumption by non-Saccharomyces yeasts may account for some of the

  14. Hvordan kan fosterbarns indre arbeidsmodeller positivt påvirkes i relasjon med nære omsorgspersoner? Knyttet opp mot SIP-modellen (Sosial informasjonsprosesserings-modell)

    OpenAIRE

    Sunde, Gunn Karin

    2014-01-01

    Master's thesis in Special education Sammendrag Det er stadig flere barn som har behov for å bli omplassert i fosterhjem (Aleris, 2012), grunnet bl.a. omsorgssvikt og utrygg tilknytning (Anke, 2007). Det vil ha innflytelse på fosterbarns indre arbeidsmodeller, som er integrerte mønster hos barnet basert på erfaringer fra samspillet med tilknytningspersonene (Bowlby, 1994). SIP-modellen gir kunnskap om barns mentale prosesser og sosiale tilpasning, og viser mulighet for modifisering av f...

  15. Differential impacts of willow and mineral fertilizer on bacterial communities and biodegradation in diesel fuel oil-contaminated soil

    Directory of Open Access Journals (Sweden)

    Mary-Cathrine C.E. Leewis

    2016-06-01

    Full Text Available Despite decades of research there is limited understanding of how vegetation impacts the ability of microbial communities to process organic contaminants in soil. Using a combination of traditional and molecular assays, we examined how phytoremediation with willow and/or fertilization affected the microbial community present and active in the transformation of diesel contaminants. In a pot study, willow had a significant role in structuring the total bacterial community and resulted in significant decreases in diesel range organics (DRO. However, stable isotope probing (SIP indicated that fertilizer drove the differences seen in community structure and function. Finally, analysis of the total variance in both pot and SIP experiments indicated an interactive effect between willow and fertilizer on the bacterial communities. This study clearly demonstrates that a willow native to Alaska accelerates DRO degradation, and together with fertilizer, increased aromatic degradation by shifting microbial community structure and the identity of active naphthalene degraders.

  16. Impact of distributed generators on the power loss and voltage profile of sub-transmission network

    Directory of Open Access Journals (Sweden)

    A.S.O. Ogunjuyigbe

    2016-05-01

    Full Text Available This paper presents the impact of distributed generator (DG on the power loss and voltage profile of sub-transmission network at different penetration levels (PLs. The various DG technologies are modeled based on their electrical output characteristics. Voltage profile index which allows a single value to represent how well the voltage matches the ideal value is developed. The index allows a fair comparison of the voltage profile obtained from different scenarios. The extent to which DGs affect power losses and voltage profile depend on the type of DG technology, PL and the location in which the DG is connected to the grid. The integration of DGs reduces power losses on the network, however, as the PL increases, the power losses begin to increase. A PL of 50–75% is achieved on 69 kV voltage level and 25–50% penetration on 13.8 kV voltage level without an increase in the power loss. Also more DG can be integrated into the network at point of common connection of higher voltage level compared to the low voltage level.

  17. The relationship between disease and function and perceived health in very frail elders.

    Science.gov (United States)

    Mulrow, C D; Gerety, M B; Cornell, J E; Lawrence, V A; Kanten, D N

    1994-04-01

    To study associations between disease and observed function and self-perceived health in very frail elders. Cross-sectional survey of nine nursing homes in San Antonio, TX. 194 elderly long-stay nursing home residents dependent in at least two ADLs and without severe cognitive impairment. Burden of disease (BOD) was chart abstracted using a standardized protocol that assessed types and severities of 59 categorizations of chronic and acute medical conditions. Observed function and self-perceived health status were assessed independently by the Katz Activities of Daily Living scale (ADL) and the Sickness Impact Profile (SIP), respectively. Summary BOD scores had a low, but statistically significant, univariate correlation with ADL scores (r = 0.21, P = 0.003) and no significant correlation with SIP scores (R = -0.008). Multiple linear regression analyses, including the 24 most frequent disease categories, showed that disease explained significant amounts of ADL (r2 = 0.25, P = 0.001) and borderline significant amounts of SIP (r2 = 0.16, P = 0.11). Models including both disease and sociodemographic, cognitive, and affective variables showed disease added significant incremental explantation beyond the other factors to ADL (incremental r2 = 0.14, P = 0.04), but not to SIP (incremental r2 = 0.08, P > 0.10). Disease, observed function, and self-perceived health status are separate, but interrelated entities, with disease having a stronger relationship to observed function than self-perceived health. Comprehensive assessment of frail elders may need to include all three areas, and studies that focus on one area should take into account the other two as potential important covariates.

  18. Time-resolved wave-profile measurements at impact velocities of 10 km/s

    Energy Technology Data Exchange (ETDEWEB)

    Chhabildas, L.C.; Furnish, M.D.; Reinhart, W.D.

    1998-06-01

    Development of well-controlled hypervelocity launch capabilities is the first step to understand material behavior at extreme pressures and temperatures not available using conventional gun technology. In this paper, techniques used to extend both the launch capabilities of a two-stage light-gas gun to 10 km/s and their use to determine material properties at pressures and temperature states higher than those ever obtained in the laboratory are summarized. Time-resolved interferometric techniques have been used to determine shock loading and release characteristics of materials impacted by titanium and aluminum fliers launched by the only developed three-stage light-gas gun at 10 km/s. In particular, the Sandia three stage light gas gun, also referred to as the hypervelocity launcher, HVL, which is capable of launching 0.5 mm to 1.0 mm thick by 6 mm to 19 mm diameter plates to velocities approaching 16 km/s has been used to obtain the necessary impact velocities. The VISAR, interferometric particle-velocity techniques has been used to determine shock loading and release profiles in aluminum and titanium at impact velocities of 10 km/s.

  19. The Impact of Mission Profile Models on the Predicted Lifetime of IGBT Modules in the Modular Multilevel Converter

    DEFF Research Database (Denmark)

    Zhang, Yi; Wang, Huai; Wang, Zhongxu

    2017-01-01

    and electrical power modeling methods on the estimated lifetime of IGBT modules in an MMC for offshore wind power application. In a 30 MW MMC case study, an annual wind speed profile with a resolution of 1 s/data, 10 minute/data, and 1 hour/data are considered, respectively. A method to re-generate higher......The reliability aspect study of Modular Multilevel Converter (MMC) is of great interest in industry applications, such as offshore wind. Lifetime prediction of key components is an important tool to design MMC with fulfilled reliability specifications. While many efforts have been made...... to the lifetime prediction of IGBT modules in renewable energy applications by considering long-term varying operation conditions (i.e., mission profile), the justifications of using the associated mission profiles are still missed. This paper investigates the impact of mission profile data resolutions...

  20. Metagenomic profiles of antibiotic resistance genes (ARGs) between human impacted estuary and deep ocean sediments.

    Science.gov (United States)

    Chen, Baowei; Yang, Ying; Liang, Ximei; Yu, Ke; Zhang, Tong; Li, Xiangdong

    2013-11-19

    Knowledge of the origins and dissemination of antibiotic resistance genes (ARGs) is essential for understanding modern resistomes in the environment. The mechanisms of the dissemination of ARGs can be revealed through comparative studies on the metagenomic profiling of ARGs between relatively pristine and human-impacted environments. The deep ocean bed of the South China Sea (SCS) is considered to be largely devoid of anthropogenic impacts, while the Pearl River Estuary (PRE) in south China has been highly impacted by intensive human activities. Commonly used antibiotics (sulfamethazine, norfloxacin, ofloxacin, tetracycline, and erythromycin) have been detected through chemical analysis in the PRE sediments, but not in the SCS sediments. In the relatively pristine SCS sediments, the most prevalent and abundant ARGs are those related to resistance to macrolides and polypeptides, with efflux pumps as the predominant mechanism. In the contaminated PRE sediments, the typical ARG profiles suggest a prevailing resistance to antibiotics commonly used in human health and animal farming (including sulfonamides, fluoroquinolones, and aminoglycosides), and higher diversity in both genotype and resistance mechanism than those in the SCS. In particular, antibiotic inactivation significantly contributed to the resistance to aminoglycosides, β-lactams, and macrolides observed in the PRE sediments. There was a significant correlation in the levels of abundance of ARGs and those of mobile genetic elements (including integrons and plasmids), which serve as carriers in the dissemination of ARGs in the aquatic environment. The metagenomic results from the current study support the view that ARGs naturally originate in pristine environments, while human activities accelerate the dissemination of ARGs so that microbes would be able to tolerate selective environmental stress in response to anthropogenic impacts.

  1. Analysis of the /sup 28/Si(p,. gamma. )/sup 29/P reaction data in the region of the sub-barrier single particle resonances

    Energy Technology Data Exchange (ETDEWEB)

    Matulewicz, T; Decowski, P; Kicinska-Habior, M; Sikora, B; Toke, J

    1983-01-01

    The /sup 28/Si(p, ..gamma..)/sup 29/P reaction data have been analyzed in terms of a modified direct-semidirect capture model which accounts for the presence of broad shape (single-particle) resonances in the entrance channel. Values of the spectroscopic factors for the ground state and 1,65 MeV and 2,88 MeV resonances in /sup 29/P nuclei were extracted and found to be consistent with those obtained in other experiments. The modified theoretical analysis scheme was found to provide a convenient tool for analyzing the radiative capture reaction data.

  2. Manufacturing and Structural Feasibility of Natural Fiber Reinforced Polymeric Structural Insulated Panels for Panelized Construction

    Directory of Open Access Journals (Sweden)

    Nasim Uddin

    2011-01-01

    Full Text Available Natural fibers are emerging in the fields of automobile and aerospace industries to replace the parts such as body panels, seats, and other parts subjected to higher bending strength. In the construction industries, they have the potential to replace the wood and oriented strand boards (OSB laminates in the structural insulated panels (SIPs. They possess numerous advantages over traditional OSB SIPs such as being environmental friendly, recyclable, energy efficient, inherently flood resistant, and having higher strength and wind resistance. This paper mainly focuses on the manufacturing feasibility and structural characterization of natural fiber reinforced structural insulated panels (NSIPs using natural fiber reinforced polymeric (NFRP laminates as skin. To account for the use of natural fibers, the pretreatments are required on natural fibers prior to use in NFRP laminates, and, to address this issue properly, the natural fibers were given bleaching pretreatments. To this end, flexure test and low-velocity impact (LVI tests were carried out on NSIPs in order to evaluate the response of NSIPs under sudden impact loading and uniform bending conditions typical of residential construction. The paper also includes a comparison of mechanical properties of NSIPs with OSB SIPs and G/PP SIPs. The results showed significant increase in the mechanical properties of resulting NSIP panels mainly a 53% increase in load-carrying capacity compared to OSB SIPs. The bending modulus of NSIPs is 190% higher than OSB SIPs and 70% weight reduction compared to OSB SIPs.

  3. Beneficial impact on cardiovascular risk profile of water buffalo meat consumption.

    Science.gov (United States)

    Giordano, G; Guarini, P; Ferrari, P; Biondi-Zoccai, G; Schiavone, B; Giordano, A

    2010-09-01

    Meat is a good source of proteins and irons, yet its consumption has been associated with unfavorable cardiovascular effects. Whether this applies to all types of meat is unclear. We thus aimed to appraise the impact of water buffalo meat consumption on cardiovascular risk profile with an observational longitudinal study. Several important cardiovascular risk features were appraised at baseline and at 12-month follow-up in 300 adult subjects divided in groups: recent consumers of water buffalo meat vs subjects who had never consumed water buffalo meat. In addition, long-standing consumers of water buffalo meat were evaluated. Age, gender, height, body weight, and the remaining diet (with the exception of cow meat consumption) were similar across groups. From baseline to follow-up, recent consumers of water buffalo meat change their intake of water buffalo meat from none to 600+/-107 g per week (Pconsumption from 504+/-104 to 4+/-28 (PConsumption of buffalo meat seems to be associated with several beneficial effects on cardiovascular risk profile. Awaiting further randomized clinical trials, this study suggests that a larger consumption of water buffalo meat could confer significant cardiovascular benefits, while continuing to provide a substantial proportion of the recommended daily allowance of protein.

  4. RISKS ASSOCIATED WITH INVESTMENTS IN STRUCTURED INVESTMENT PRODUCTS, SELECTION CRITERIA OF SIP`S

    Directory of Open Access Journals (Sweden)

    Ignatyuk Aleksandr Sergeevich

    2013-05-01

    Full Text Available Purpose To identify and classify the major risks affecting on the structured investment products, to submit proposals to limit their impact. Methodology The work is based on a studying of the practice of investments in structured investment products, detection and investigation of sources of market risk of structured investment products. Results Structured investment products, as any other investment product, has a significant set of risks that could affect to a large extent on its evaluation and determine the behavior of the investor. Financial engineers have the ability to control most of these risks, as well as to limit their impact. Thus, the structured investment product, unlike most classic investment instruments can provide investors with highly transparent mechanism to determining the ratio of investment risk and potential income. Practical implications The results can be used in a scientific investigation of the phenomenon of structured investment products, as well as practical work on the formation of the structured products by investment banks and brokerage firms.

  5. Radio frequency measurements of tunnel couplings and singlet–triplet spin states in Si:P quantum dots

    Science.gov (United States)

    House, M. G.; Kobayashi, T.; Weber, B.; Hile, S. J.; Watson, T. F.; van der Heijden, J.; Rogge, S.; Simmons, M. Y.

    2015-01-01

    Spin states of the electrons and nuclei of phosphorus donors in silicon are strong candidates for quantum information processing applications given their excellent coherence times. Designing a scalable donor-based quantum computer will require both knowledge of the relationship between device geometry and electron tunnel couplings, and a spin readout strategy that uses minimal physical space in the device. Here we use radio frequency reflectometry to measure singlet–triplet states of a few-donor Si:P double quantum dot and demonstrate that the exchange energy can be tuned by at least two orders of magnitude, from 20 μeV to 8 meV. We measure dot–lead tunnel rates by analysis of the reflected signal and show that they change from 100 MHz to 22 GHz as the number of electrons on a quantum dot is increased from 1 to 4. These techniques present an approach for characterizing, operating and engineering scalable qubit devices based on donors in silicon. PMID:26548556

  6. Economic information from Smart Meter: Nexus Between Demand Profile and Electricity Retail Price Between Demand Profile and Electricity Retail Price

    OpenAIRE

    Yu, Yang; Liu, Guangyi; Zhu, Wendong; Wang, Fei; Shu, Bin; Zhang, Kai; Rajagopal, Ram; Astier, Nicolas

    2016-01-01

    In this paper, we demonstrate that a consumer's marginal system impact is only determined by their demand profile rather than their demand level. Demand profile clustering is identical to cluster consumers according to their marginal impacts on system costs. A profile-based uniform-rate price is economically efficient as real-time pricing. We develop a criteria system to evaluate the economic efficiency of an implemented retail price scheme in a distribution system by comparing profile cluste...

  7. On the bright and dark side of public service motivation : the relationship between PSM and employee wellbeing

    NARCIS (Netherlands)

    van Loon, Nina Mari; Vandenabeele, Wouter|info:eu-repo/dai/nl/323038816; Leisink, Peter|info:eu-repo/dai/nl/071055266

    2015-01-01

    This paper reveals that the relationship between public service motivation (PSM) and employee wellbeing depends on the societal impact potential (SIP) through the job and organizational type. In people-changing organizations, PSM relates to higher burnout and lower job satisfaction when SIP is high:

  8. Radioimmunotherapy targeting the extra domain B of fibronectin in C6 rat gliomas: a preliminary study about the therapeutic efficacy of iodine-131-labeled SIP(L19)

    International Nuclear Information System (INIS)

    Spaeth, Nicolas; Wyss, Matthias T.; Pahnke, Jens; Biollaz, Gregoire; Trachsel, Eveline; Drandarov, Konstantin; Treyer, Valerie; Weber, Bruno; Neri, Dario; Buck, Alfred

    2006-01-01

    Despite aggressive treatment protocols, patients suffering from glioblastoma multiforme still experience poor outcome. Therefore, new adjuvant therapeutic options such as radioimmunotherapy (RIT) have been studied and have resulted in significant survival benefit. In this study, we assessed the efficacy of a novel radioimmunotherapeutic approach targeting the extra domain B (EDB) of fibronectin, a marker of angiogenesis, in glioma-bearing rats. Methods: C6 gliomas were induced intracerebrally in Wistar rats. Ten to 11 days later, 220-360 MBq of iodine-131-labeled anti-EDB SIP(L19) ('small immunoprotein') was administered intravenously into nine animals, yielding a radiation dose of 13-21 Gy. Another nine rats served as controls. Then the following parameters were compared: median survival time, tumor size and histology. Results: Histological examination of the tumors revealed typical glioblastoma characteristics. Eleven of 18 rats developed a tumor size bigger than 150 mm 3 . When these animals were used for survival analysis, median survival did significantly differ between groups [22 days (therapy; n=7) vs. 16 days (control; n=4); P 131 I-SIP(L19)-RIT showed promising potential in treating C6 gliomas, warranting further studies. However, larger trials with preferentially higher doses are needed to confirm this finding and, potentially, to further increase the efficacy of this treatment

  9. Impact of Scheduling Flexibility on Demand Profile Flatness and User Inconvenience in Residential Smart Grid System

    Directory of Open Access Journals (Sweden)

    Naveed Ul Hassan

    2013-12-01

    Full Text Available The objective of this paper is to study the impact of scheduling flexibility on both demand profile flatness and user inconvenience in residential smart grid systems. Temporal variations in energy consumption by end users result in peaks and troughs in the aggregated demand profile. In a residential smart grid, some of these peaks and troughs can be eliminated through appropriate load balancing algorithms. However, load balancing requires user participation by allowing the grid to re-schedule some of their loads. In general, more scheduling flexibility can result in more demand profile flatness, however the resulting inconvenience to users would also increase. In this paper, our objective is to help the grid determine an appropriate amount of scheduling flexibility that it should demand from users, based on which, proper incentives can be designed. We consider three different types of scheduling flexibility (delay, advance scheduling and flexible re-scheduling in flexible loads and develop both optimal and sub-optimal scheduling algorithms. We discuss their implementation in centralized and distributed manners. We also identify the existence of a saturation point. Beyond this saturation point, any increase in scheduling flexibility does not significantly affect the flatness of the demand profile while user inconvenience continues to increase. Moreover, full participation of all the households is not required since increasing user participation only marginally increases demand profile flatness.

  10. Development of the life impact burn recovery evaluation (LIBRE) profile: assessing burn survivors' social participation.

    Science.gov (United States)

    Kazis, Lewis E; Marino, Molly; Ni, Pengsheng; Soley Bori, Marina; Amaya, Flor; Dore, Emily; Ryan, Colleen M; Schneider, Jeff C; Shie, Vivian; Acton, Amy; Jette, Alan M

    2017-10-01

    Measuring the impact burn injuries have on social participation is integral to understanding and improving survivors' quality of life, yet there are no existing instruments that comprehensively measure the social participation of burn survivors. This project aimed to develop the Life Impact Burn Recovery Evaluation Profile (LIBRE), a patient-reported multidimensional assessment for understanding the social participation after burn injuries. 192 questions representing multiple social participation areas were administered to a convenience sample of 601 burn survivors. Exploratory factor analysis and confirmatory factor analysis (CFA) were used to identify the underlying structure of the data. Using item response theory methods, a Graded Response Model was applied for each identified sub-domain. The resultant multidimensional LIBRE Profile can be administered via Computerized Adaptive Testing (CAT) or fixed short forms. The study sample included 54.7% women with a mean age of 44.6 (SD 15.9) years. The average time since burn injury was 15.4 years (0-74 years) and the average total body surface area burned was 40% (1-97%). The CFA indicated acceptable fit statistics (CFI range 0.913-0.977, TLI range 0.904-0.974, RMSEA range 0.06-0.096). The six unidimensional scales were named: relationships with family and friends, social interactions, social activities, work and employment, romantic relationships, and sexual relationships. The marginal reliability of the full item bank and CATs ranged from 0.84 to 0.93, with ceiling effects less than 15% for all scales. The LIBRE Profile is a promising new measure of social participation following a burn injury that enables burn survivors and their care providers to measure social participation.

  11. Impact of body mass index, age and varicocele on reproductive hormone profile from elderly men

    Directory of Open Access Journals (Sweden)

    K. G. R. Yamaçake

    2016-04-01

    Full Text Available ABSTRACT Objectives: To study the impact of obesity, age and varicocele on sexual hormones fof adult and elderly men. Materials and Methods: 875 men who were screened for prostate cancer were enrolled in this study. Data recorded comprised age, body mass index (BMI, serum levels of total testosterone (TT, free testosterone (FT, sex hormone-binding globulin (SHBG, luteinizing hormone (LH and follicular stimulating hormone (FSH. Patients were divided in groups according to their BMI in underweight, normal weight, overweight and obese grades 1, 2 or 3. First, it was studied the association between age, BMI, and hormone profile. Then, clinical varicocele was evaluated in 298 patients to assess its correlation to the others parameters. Results: Obese patients had lower levels of TT, FT and SHBG (p<0.001 compared to underweight or normal weight patients. There were no differences in age (p=0.113, FSH serum levels (p=0.863 and LH serum levels (p=0.218 between obese and non-obese patients. Obese grade 3 had lower levels of TT and FT compared to obese grade 1 and 2 (p<0.05. There was no difference in the SHBG levels (p=0.120 among obese patients. There was no association between varicocele and BMI; and varicocele did not impact on testosterone or SHBG levels. Conclusions: Men with higher BMI have a lower serum level of TT, FT and SHBG. The presence of clinical varicocele as well as its grade has no impact on hormone profile in elderly men.

  12. 75 FR 48864 - Approval and Promulgation of Air Quality Implementation Plans; MN

    Science.gov (United States)

    2010-08-12

    ... Hospital performed an air quality analysis to address the facility's impact on the SO 2 NAAQS. The facility... Promulgation of Air Quality Implementation Plans; MN AGENCY: Environmental Protection Agency (EPA). ACTION... (SIP) for sulfur dioxide (SO 2 ). The Minnesota Pollution Control Agency (MPCA) submitted the SIP...

  13. The impact of genetics and hormonal contraceptives on the steroid profile in female athletes

    Directory of Open Access Journals (Sweden)

    Jenny Erkander Mullen

    2014-04-01

    Full Text Available The steroid module of the Athlete Biological Passport (ABP, the newest innovation in doping testing, is currently being finalized for implementation. Several factors, other than doping, can affect the longitudinal steroid profile. In this study we investigated the effect of hormonal contraceptives as well as the effect of three polymorphisms on female steroid profiles in relation to doping controls.The study population consisted of 79 female elite athletes between the ages of 18 to 45. Hormonal contraceptives were used by 32 % of the subjects. A full urinary steroid profile was obtained using World Anti-Doping Agency accredited methods. In addition all subjects were genotyped for copy number variation of UGT2B17 and SNPs in UGT2B7 and CYP17.Subjects using hormonal contraceptives excreted 40 % less epitestosterone as compared to non-users (p = 0.005 but showed no difference in testosterone excretion. When removing individuals homozygous for the deletion in UGT2B17, the testosterone to epitestosterone (T/E ratio was 29 % higher in the hormonal contraceptives group (p = 0.016. In agreement with previous findings in men, copy number variation of UGT2B17 had significant effect on female urinary testosterone excretion and therefore also the T/E ratio. Subjects homozygous for the T allele of CYP17 showed a lower urinary epitestosterone concentration than the other CYP17 genotypes. It is of great importance that the athlete’s steroidal passport can compensate for all possible normal variability in steroid profiles from women. Therefore, considering the large impact of hormonal contraceptives on female steroid profiles, we suggest that the use of hormonal contraceptives should be a mandatory question on the doping control form.

  14. Impact of AIRS Thermodynamic Profile on Regional Weather Forecast

    Science.gov (United States)

    Chou, Shih-Hung; Zavodsky, Brad; Jedlovee, Gary

    2010-01-01

    Prudent assimilation of AIRS thermodynamic profiles and quality indicators can improve initial conditions for regional weather models. AIRS-enhanced analysis has warmer and moister PBL. Forecasts with AIRS profiles are generally closer to NAM analyses than CNTL. Assimilation of AIRS leads to an overall QPF improvement in 6-h accumulated precipitation forecasts. Including AIRS profiles in assimilation process enhances the moist instability and produces stronger updrafts and a better precipitation forecast than the CNTL run.

  15. Impact of profile observations on the German Weather Service's NWP system

    Directory of Open Access Journals (Sweden)

    Alexander Cress

    2001-04-01

    Full Text Available In preparation for a study on the potential impact of a space-borne Doppler wind lidar on the quality of NWP products, a series of assimilations and forecasts were conducted to estimate the potential benefit of conventional wind and temperature profile measurements over North America to numerical weather forecasts for the Northern Hemisphere and specifically, Europe. A comparison of the forecast quality of a control run, using all available observations, to experiments omitting wind and temperature data from specific instruments (radiosondes, pilot stations and aircraft makes it possible to estimate the importance of the omitted data, and clarify whether winds derived from the geostrophic relation are sufficient or whether observed wind profiles result in a more realistic definition of the initial state for numerical weather prediction systems in the extra-tropic regions. Very little impact on forecast quality was noted when wind or temperature observations from radiosondes and pilots were excluded from the assimilation process. However, a clear deterioration in forecast quality was observed when additionally all available wind or temperature measurements from aircraft were also withheld. Comparisons of the relative utility of wind and temperature observations over North America show that assimilations and forecasts derive more benefit from wind data than from temperature data. The greatest deterioration could be observed if both wind and temperature observations were omitted from the assimilation cycle. By tracing the differences between the control forecasts and the experimental forecasts to their initial difference, the regions around Hudson Bay, Novia Scotia, Buffin Bay and Northern Canada could be identified as sensitive areas, i.e. those where a missing observation could have a substantial effect on the forecast for the Northern Hemisphere and Europe. Comparisons of the relative utility of radiosonde wind and temperature observations over

  16. A randomised clinical trial of routine versus selective CT imaging in acute abdomen: Impact of patient age on treatment costs and hospital resource use

    Energy Technology Data Exchange (ETDEWEB)

    Lehtimäki, Tiina T., E-mail: tiina.lehtimaki@kuh.fi [Department of Clinical Radiology, Kuopio University Hospital, Puijonlaaksontie 2, FI-70210, Kuopio (Finland); Valtonen, Hannu, E-mail: hannu.valtonen@uef.fi [University of Eastern Finland, Department of Health and Social Management, Yliopistonranta 1, FI-70211 Kuopio (Finland); Miettinen, Pekka, E-mail: pekka.miettinen@satucon.fi [Department of Gastrointestinal Surgery, Kuopio University Hospital, Puijonlaaksontie 2, FI-70210 Kuopio (Finland); Juvonen, Petri, E-mail: petri.juvonen@kuh.fi [Department of Gastrointestinal Surgery, Kuopio University Hospital, Puijonlaaksontie 2, FI-70210 Kuopio (Finland); Paajanen, Hannu, E-mail: hannu.paajanen@kuh.fi [Department of Gastrointestinal Surgery, Kuopio University Hospital, Puijonlaaksontie 2, FI-70210 Kuopio (Finland); University of Eastern Finland, Department of Clinical Medicine, Unit of Surgery, Yliopistonranta 1, FI-70211 Kuopio (Finland); Vanninen, Ritva, E-mail: ritva.vanninen@kuh.fi [Department of Clinical Radiology, Kuopio University Hospital, Puijonlaaksontie 2, FI-70210, Kuopio (Finland); University of Eastern Finland, Department of Clinical Medicine, Unit of Radiology, Yliopistonranta 1, FI-70211 Kuopio (Finland)

    2017-02-15

    Objectives: To evaluate the impact of patient age on hospital resource use and treatment costs of acute abdominal pain (AAP). Materials and methods: A total of 300 adult patients with AAP were randomised to either computed tomography (CT, n = 150) or selective imaging practice (SIP, n = 150) groups. Final analysis included 254 patients, 143 (42 patients ≥65 years) in the CT and 111 (32 patients ≥65 years) in the SIP group. All CT group patients underwent abdominal CT whereas in the SIP group, imaging was based on the clinical assessment. For each patient, the hospital length of stay (LOS), the numbers and costs of diagnostic and treatment procedures arising from AAP were calculated and registered. The incremental cost-effectiveness ratio (ICER) and bootstrapped cost-effectiveness acceptability curve (CEAC) were estimated for routine CT. Results: Treatment costs, imaging costs and LOS increased in conjunction with aging in both study groups, and were generally higher in the CT group compared to the SIP group. In the SIP group, CT was undertaken in 34% (27/79) of the <65 year olds but in 59% (19/32) of the older patients (≥65 years) (p = 0.02). The proportion of patients with non-specific abdominal pain was significantly lower in patients ≥65 years than in their younger counterparts (p = 0.04). In the routine CT group, the ICER of obtaining a specific diagnosis was 1682 € for patients <65 years and 1055 € for patients ≥65 years. According to CEAC estimation, routine CT for every patient with AAP has a 95% probability of being cost-effective if society is willing to pay 14087 € for an additional specific diagnosis for patients <65 years but only 4204 € in those ≥65 years. Conclusion: Treatment costs of AAP increase in parallel with aging, and the costs are generally higher with routine CT compared to selective imaging. The probability of obtaining a specific diagnosis of AAP increases with aging. If obtaining a specific diagnosis is deemed crucial

  17. Impact of measurement approach on the quality of gamma scanning density profile in a tray type lab-scale column

    International Nuclear Information System (INIS)

    Shahabinejad, H.; Feghhi, S.A.H.; Khorsandi, M.

    2014-01-01

    This article presents a study for investigating impact of the measurement approach on the quality of gamma scanning density profile in tray type columns using experimental and computational evaluations. Experimental density profiles from the total and the photopeak count measurements, as two approaches in gamma ray column scanning technique, has been compared with the computational density profile from Monte Carlo simulation results. We used a laboratory distillation column of 51 cm diameter as an illustrative example for this investigation. 137 Cs was used as a gamma ray source with the activity of 296 MBq (8 mCi), with a NaI(Tl) detector. MCNP4C Monte Carlo code has been used for simulations. The quality of the density profile in the photopeak count approach is relatively within 155–204% better than that of the total count approach for experimental results. The same comparison for simulation results leads to a relative difference within 100–135% for the density profile. - Highlights: • The quality of density profile in gamma scanning technique has been studied. • Quality of density profile depends on the measurement approach. • A laboratory distillation column has been used as an illustrative example. • MCNP4C Monte Carlo code has been used for simulations

  18. [Development and reliability evaluation of an instrument to measure health-related quality of life in independent elderly].

    Science.gov (United States)

    Lima, Maria José Barbosa de; Portela, Margareth Crisóstomo

    2010-08-01

    This study presents an instrument, the health-related quality of life (HRQOL) profile for independent elderly, to measure the health-related quality of life of the functionally independent elderly assisted in the outpatient setting, based on the adaptation of four validated scales: Short-Form Health Survey (SF-36), Duke-UNC Health Profile (DUHP), Sickness Impact Profile (SIP), and Nottingham Health Profile (NHP). The study also evaluates the instrument's reliability based on its use by two different observers with a 15-day interval. The instrument includes five dimensions (health perception, symptoms, physical function, psychological function, and social function) and 45 items. Reliability evaluation of the QUASI instrument was based on interviews with 142 elderly outpatients in the city of Rio de Janeiro, Brazil. Prevalence-adjusted kappa statistic was used to assess all 45 items. Correlation was also calculated between overall scores and scores on individual dimensions. In the reliability evaluation, 39 of the 45 items showed prevalence-adjusted kappa greater than 0.60.

  19. Nutrient profiling for product reformulation: public health impact and benefits for the consumer.

    Science.gov (United States)

    Lehmann, Undine; Charles, Véronique Rheiner; Vlassopoulos, Antonis; Masset, Gabriel; Spieldenner, Jörg

    2017-08-01

    The food industry holds great potential for driving consumers to adopt healthy food choices as (re)formulation of foods can improve the nutritional quality of these foods. Reformulation has been identified as a cost-effective intervention in addressing non-communicable diseases as it does not require significant alterations of consumer behaviour and dietary habits. Nutrient profiling (NP), the science of categorizing foods based on their nutrient composition, has emerged as an essential tool and is implemented through many different profiling systems to guide reformulation and other nutrition policies. NP systems should be adapted to their specific purposes as it is not possible to design one system that can equally address all policies and purposes, e.g. reformulation and labelling. The present paper discusses some of the key principles and specificities that underlie a NP system designed for reformulation with the example of the Nestlé nutritional profiling system. Furthermore, the impact of reformulation at the level of the food product, dietary intakes and public health are reviewed. Several studies showed that food and beverage reformulation, guided by a NP system, may be effective in improving population nutritional intakes and thereby its health status. In order to achieve its maximum potential and modify the food environment in a beneficial manner, reformulation should be implemented by the entire food sector. Multi-stakeholder partnerships including governments, food industry, retailers and consumer associations that will state concrete time-bound objectives accompanied by an independent monitoring system are the potential solution.

  20. Forefoot deformity, pain, and mobility in rheumatoid and nonarthritic subjects.

    Science.gov (United States)

    O'Connell, P G; Lohmann Siegel, K; Kepple, T M; Stanhope, S J; Gerber, L H

    1998-09-01

    To evaluate how painful metatarsal arthritis affects foot and ankle mechanics and mobility. We studied 16 symptomatic forefeet in 10 patients with rheumatoid arthritis (RA) and compared them with 14 asymptomatic forefeet in 7 nonarthritic subjects. RA limbs with significant disease at other locations were excluded. We measured pain and deformity of the foot using a visual analog scale and a modified articular index. A video based 3 dimensional gait analysis system and force platform were used to collect data on subjects walking barefoot at a self-selected pace according to an established protocol. Mobility level was quantified using the Sickness Impact Profile (SIP) ambulation subscale. We observed considerable pain and deformity of the forefeet of RA subjects. During gait, motion and force measures revealed that RA subjects significantly (p SIP scores revealed that these changes in gait resulted in moderate disability in RA subjects (p=0.05). Impairments of the forefoot due to RA include pain and deformity, which produce characteristic stance phase abnormalities in foot function, a slow walking speed, and moderate disability.

  1. Pitfalls in Measuring the Health Status of Mexican Americans: Comparative Validity of the English and Spanish Sickness Impact Profile.

    Science.gov (United States)

    Deyo, Richard A.

    1984-01-01

    A test found responses to the Sickness Impact Profile highly reliable, whether administered in Spanish or English. However, construct validity of responses by Mexican Americans using the Spanish version, non-Hispanics using the English version, and Mexican Americans using the English version was weak. (CMG)

  2. Esquema de redundancia y distribución de carga de alta disponibilidad para la prestación de telefonía ip usando sip (junio 2009)

    OpenAIRE

    PARRA L., ANDRÉS; GUERRERO, FABIO G.

    2010-01-01

    En este artículo se presenta un esquema de distribución de carga y redundancia en la infraestructura de un ISP (Internet Service Provider) para la prestación de servicios de telefonía IP (ITSPs) sobre Internet usando el protocolo SIP (Session Initiation Protocol) garantizando niveles de acceso al servicio similares a la PSTN (Public Switched Telephone Network) y brindando una infraestructura de red escalable. La solución se plantea en tres partes: redundancia del servicio y distribución de ca...

  3. Intra-tumor heterogeneity in breast cancer has limited impact on transcriptomic-based molecular profiling.

    Science.gov (United States)

    Karthik, Govindasamy-Muralidharan; Rantalainen, Mattias; Stålhammar, Gustav; Lövrot, John; Ullah, Ikram; Alkodsi, Amjad; Ma, Ran; Wedlund, Lena; Lindberg, Johan; Frisell, Jan; Bergh, Jonas; Hartman, Johan

    2017-11-29

    Transcriptomic profiling of breast tumors provides opportunity for subtyping and molecular-based patient stratification. In diagnostic applications the specimen profiled should be representative of the expression profile of the whole tumor and ideally capture properties of the most aggressive part of the tumor. However, breast cancers commonly exhibit intra-tumor heterogeneity at molecular, genomic and in phenotypic level, which can arise during tumor evolution. Currently it is not established to what extent a random sampling approach may influence molecular breast cancer diagnostics. In this study we applied RNA-sequencing to quantify gene expression in 43 pieces (2-5 pieces per tumor) from 12 breast tumors (Cohort 1). We determined molecular subtype and transcriptomic grade for all tumor pieces and analysed to what extent pieces originating from the same tumors are concordant or discordant with each other. Additionally, we validated our finding in an independent cohort consisting of 19 pieces (2-6 pieces per tumor) from 6 breast tumors (Cohort 2) profiled using microarray technique. Exome sequencing was also performed on this cohort, to investigate the extent of intra-tumor genomic heterogeneity versus the intra-tumor molecular subtype classifications. Molecular subtyping was consistent in 11 out of 12 tumors and transcriptomic grade assignments were consistent in 11 out of 12 tumors as well. Molecular subtype predictions revealed consistent subtypes in four out of six patients in this cohort 2. Interestingly, we observed extensive intra-tumor genomic heterogeneity in these tumor pieces but not in their molecular subtype classifications. Our results suggest that macroscopic intra-tumoral transcriptomic heterogeneity is limited and unlikely to have an impact on molecular diagnostics for most patients.

  4. Multiple Sclerosis Impact Profile (MSIP). An ICF-based outcome measure for Disability and Disability Perception in MS. A manual.

    NARCIS (Netherlands)

    Wynia, K.; Middel, B.; Reijneveld, S.A.

    2009-01-01

    The aim of this manual is to support working with the Multiple Sclerosis Impact Profile (MSIP), a self-report measure for people with Multiple Sclerosis (MS) to assess disability and disability perception in research and clinical practice. On individual level the MSIP reflects a persons disease

  5. Metformin impacts cecal bile acid profiles in mice.

    Science.gov (United States)

    Sillner, Nina; Walker, Alesia; Koch, Wendelin; Witting, Michael; Schmitt-Kopplin, Philippe

    2018-04-15

    Bile acids (BAs) are major components of bile synthesized from cholesterol and take part in the digestion of dietary lipids, as well as having signaling functions. They undergo extensive microbial metabolism inside the gastrointestinal tract. Here, we present a method of ultra-high pressure liquid chromatography coupled to ion trap mass spectrometry for quantification of 45 BAs in mouse cecum. The system was validated in regard to sensitivity with limits of detection and quantification (0.6-24.9 nM), interday accuracy (102.4%), interday precision (15.2%), recovery rate (74.7%), matrix effect (98.2%) and carry-over effect (mice were treated with metformin for 1 day or 14 days. One day of treatment resulted in a significant increase of total BA concentration (2.7-fold increase; db/db metformin 5.32 μmol/g, db/db control mice 1.95 μmol/g), most notable in levels of 7-oxodeoxycholic, 3-dehydrocholic and cholic acid. We observed only minor impact on BA metabolism after 14 days of metformin treatment, compared to the single treatment. Furthermore, healthy wild type mice had elevated concentrations of allocholic and ω-muricholic acid compared to diabetic mice. Our method proved the applicability of profiling BAs in cecum to investigate intestinal BA metabolism in diabetes and pharmacological applications. Copyright © 2018 Elsevier B.V. All rights reserved.

  6. The impact of antibody profile in thrombosis associated with primary antiphospholipid syndrome.

    Science.gov (United States)

    da Silva Saraiva, Sabrina; de Moraes Mazetto, Bruna; Quinteiro Tobaldine, Lais; Pereira Colella, Marina; Vinícius De Paula, Erich; Annichinno-Bizzachi, Joyce; Andrade Orsi, Fernanda

    2017-11-01

    Triple positivity (TP) for antiphospholipid antibodies(aPL) may identify aPL carriers with poorer prognosis. The clinical impact of TP in primary antiphospholipid syndrome(PAPS) remains unclear and further clinical evidences are needed to validate TP as a marker of severity. The aim of this study was to evaluate the impact of TP on the clinical course of PAPS with thrombosis(t-PAPS). We performed a retrospective analysis of a cohort of t-PAPS patients, comparing groups of patients with TP and non-TP profiles according to their demographic, clinical and laboratory features. We included 105 patients with t-PAPS, the median follow-up time of 3.7 years. Twenty-two patients(21%) had TP; the demographic distribution, the presence of cardiovascular risk factors and the site of thrombosis were similar between TP and non-TP patients. The frequency of thrombotic events did not differ between TP and non-TP patients during the study period. Pregnancy morbidities were more frequent in women with t-PAPS and TP than in those with non-TP profile (80% vs. 52.8%, P = 0.05). Patients with t-PAPS and TP presented, at diagnosis, higher dRVVT ratio (median R = 2.44 vs. 1.57, P < 0.0001), higher aCL titer (median = 50UI vs. 35 UI, P < 0.0001), lower C3 levels (median = 1.08 vs. 1.30 mg dL -1 , P = 0.001), lower C4 levels (median = 0.22 vs. 0.25 mg dL -1 , P = 0.05) and higher frequency of positive ANA test (50% vs. 20%, P = 0.008) than patients with t-PAPS and non-TP. Lower-than-normal levels of C3 was independently associated with TP (OR = 5.1, P = 0.02). The presence of TP in patients with t-PAPS was associated with immune derangement, with no effect on the clinical course of the disease. © 2017 Wiley Periodicals, Inc.

  7. 78 FR 24373 - Approval and Promulgation of Air Quality Implementation Plans; Wisconsin; Amendments to Vehicle...

    Science.gov (United States)

    2013-04-25

    ... requirements for non-OBDII equipped vehicles. This change impacted MY 1968 through 1995 vehicles. These....134 0.193 0.060 0.097 0.037 0.063 0.027 0.041 \\3\\ Volatile organic compound. \\4\\ Oxides of nitrogen... part of the 110(l) demonstration. Table 3--(SIP I/M Program vs. Current I/M Program) SIP I/M program...

  8. Louisiana SIP: LAC 33:III Ch. 14 Subchap B, 1431 to 1434--Conformity to State or Federal Implementation Plans of Transportation Plans, Programs, and Projects Developed, Funded, or Approved Under Title 23 U.S.C. or the Federal Transit Laws

    Science.gov (United States)

    Louisiana SIP: LAC 33:III Ch. 14 Subchap B, 1431 to 1434--Conformity to State or Federal Implementation Plans of Transportation Plans, Programs, and Projects Developed, Funded, or Approved Under Title 23 U.S.C. or the Federal Transit Laws

  9. Active methanotrophs in two contrasting North American peatland ecosystems revealed using DNA-SIP.

    Science.gov (United States)

    Gupta, Varun; Smemo, Kurt A; Yavitt, Joseph B; Basiliko, Nathan

    2012-02-01

    The active methanotroph community was investigated in two contrasting North American peatlands, a nutrient-rich sedge fen and nutrient-poor Sphagnum bog using in vitro incubations and (13)C-DNA stable-isotope probing (SIP) to measure methane (CH(4)) oxidation rates and label active microbes followed by fingerprinting and sequencing of bacterial and archaeal 16S rDNA and methane monooxygenase (pmoA and mmoX) genes. Rates of CH(4) oxidation were slightly, but significantly, faster in the bog and methanotrophs belonged to the class Alphaproteobacteria and were similar to other methanotrophs of the genera Methylocystis, Methylosinus, and Methylocapsa or Methylocella detected in, or isolated from, European bogs. The fen had a greater phylogenetic diversity of organisms that had assimilated (13)C, including methanotrophs from both the Alpha- and Gammaproteobacteria classes and other potentially non-methanotrophic organisms that were similar to bacteria detected in a UK and Finnish fen. Based on similarities between bacteria in our sites and those in Europe, including Russia, we conclude that site physicochemical characteristics rather than biogeography controlled the phylogenetic diversity of active methanotrophs and that differences in phylogenetic diversity between the bog and fen did not relate to measured CH(4) oxidation rates. A single crenarchaeon in the bog site appeared to be assimilating (13)C in 16S rDNA; however, its phylogenetic similarity to other CO(2)-utilizing archaea probably indicates that this organism is not directly involved in CH(4) oxidation in peat.

  10. Psychosocial work factors and sleep problems: findings from the French national SIP survey.

    Science.gov (United States)

    Chazelle, Emilie; Chastang, Jean-François; Niedhammer, Isabelle

    2016-04-01

    This study aimed at exploring the cross-sectional and prospective associations between psychosocial work factors and sleep problems. The study population consisted of a national representative sample of the French working population (SIP survey). The sample sizes were 7506 and 3555 for the cross-sectional and prospective analyses. Sleep problems were defined by either sleep disturbances or insufficient sleep duration at least several times a week. Psychosocial work factors included classical (job strain model factors) and emergent factors (recognition, insecurity, role/ethical conflict, emotional demands, work-life imbalance, etc.). Occupational factors related to working time/hours and physical work environment were also included as well as covariates related to factors outside work. Statistical analyses were performed using weighted Poisson regression analysis. In the cross-sectional analyses, psychological demands, low social support, low recognition, emotional demands, perception of danger, work-life imbalance and night work were found to be associated with sleep problems. In the prospective analyses, psychological demands and night work were predictive of sleep problems. Using a less conservative method, more factors were found to be associated with sleep problems. Dose-response associations were observed, showing that the more frequent the exposure to these factors, the higher the risk of sleep problems. No effect of repeated exposure was found on sleep problems. Classical and emergent psychosocial work factors were associated with sleep problems. More prospective studies and prevention policies may be needed.

  11. Efficient non-viral reprogramming of myoblasts to stemness with a single small molecule to generate cardiac progenitor cells.

    Directory of Open Access Journals (Sweden)

    Zeeshan Pasha

    Full Text Available The current protocols for generation of induced pluripotent stem (iPS cells involve genome integrating viral vectors which may induce tumorgenesis. The aim of this study was to develop and optimize a non-viral method without genetic manipulation for reprogramming of skeletal myoblasts (SMs using small molecules.SMs from young male Oct3/4-GFP(+ transgenic mouse were treated with DNA methyltransferase (DNMT inhibitor, RG108. Two weeks later, GFP(+ colonies of SM derived iPS cells (SiPS expressing GFP and with morphological similarity of mouse embryonic stem (ESCs were formed and propagated in vitro. SiPS were positive for alkaline phosphatase activity, expressed SSEA1, displayed ES cell specific pluripotency markers and formed teratoma in nude mice. Optimization of culture conditions for embryoid body (EBs formation yielded spontaneously contracting EBs having morphological, molecular, and ultra-structural similarities with cardiomyocytes and expressed early and late cardiac markers. miR profiling showed abrogation of let-7 family and upregulation of ESCs specific miR-290-295 cluster thus indicating that SiPS were similar to ESCs in miR profile. Four weeks after transplantation into the immunocompetent mice model of acute myocardial infarction (n = 12 per group, extensive myogenesis was observed in SiPS transplanted hearts as compared to DMEM controls (n = 6 per group. A significant reduction in fibrosis and improvement in global heart function in the hearts transplanted with SiPS derived cardiac progenitor cells were observed.Reprogramming of SMs by DNMT inhibitor is a simple, reproducible and efficient technique more likely to generate transgene integration-free iPS cells. Cardiac progenitors derived from iPS cells propagated extensively in the infarcted myocardium without tumorgenesis and improved cardiac function.

  12. Impacto de un programa de atención domiciliaria al enfermo crónico en ancianos: calidad de vida y reingresos hospitalarios Impact of the program home care for the chronically ill for elderly: quality of life and hospital readmissions

    Directory of Open Access Journals (Sweden)

    María Claudia Espinel-Bermúdez

    2011-02-01

    Full Text Available OBJETIVO: Evaluar el impacto del programa Atención Domiciliaria al Enfermo Crónico (ADEC comparado con la atención habitual (AH a ancianos con dependencia funcional, derechohabientes del Instituto Mexicano del Seguro Social (IMSS. MATERIAL Y MÉTODOS: Cohorte prospectiva a tres meses a partir del egreso hospitalario en dos hospitales de la Ciudad de México. Se ingresaron 130 ancianos con dependencia funcional, 70 insertados al programa ADEC y 60 con atención habitual. Se midió impacto en reingresos hospitalarios y calidad de vida a partir de la escala Perfil de Impacto de la Enfermedad (SIP, por sus siglas en inglés. RESULTADOS: La edad promedio de los ancianos fue de 74 años (61/103 y 60% fueron mujeres. El principal diagnóstico fue enfermedad vascular cerebral (EVC (30.77%. El grupo de ADEC mejoró la calidad de vida en la dimensión psicosocial [46.26 (±13.85 comparado con 29.45 (±16.48 vs. 47.03 (±16.47 a 42.36 (±16.35 p0.05. CONCLUSIONES: El programa mejoró la dimensión psicosocial de calidad de vida.OBJECTIVE: To evaluate the impact of the ADEC program (acronym in Spanish as compared with the typical care provided to disabled elderly affiliated with the Mexican Institute of Social Security (IMSS. MATERIAL AND METHODS: Prospective cohort at three months after discharge from two general hospitals in Mexico City. A total of 130 patients with functional dependency were studied, 70 in the ADEC program and 60 with typical care. Impact was measured using hospital readmissions and quality of life based on the Sickness Impact Profile (SIP. RESULTS: Average age was 74 (61/103 years and 60% were women. The main diagnosis was cerebrovascular disease (30.77%. The quality of life in the psychosocial dimension improved for the ADEC group (from 46.26 (±13.85 to 29.45(±16.48 as compared with 47.03 (±16.47 to 42.36 (±16.35 for those receiving typical care (p0.05. CONCLUSIONS: HC program improved the psychosocial dimension of quality of

  13. Heat demand profiles of energy conservation measures in buildings and their impact on a district heating system

    International Nuclear Information System (INIS)

    Lundström, Lukas; Wallin, Fredrik

    2016-01-01

    Highlights: • Energy savings impact on an low CO 2 emitting district heating system. • Heat profiles of eight building energy conservation measures. • Exhaust air heat pump, heat recovery ventilation, electricity savings etc. • Heat load weather normalisation with segmented multivariable linear regression. - Abstract: This study highlights the forthcoming problem with diminishing environmental benefits from heat demand reducing energy conservation measures (ECM) of buildings within district heating systems (DHS), as the supply side is becoming “greener” and more primary energy efficient. In this study heat demand profiles and annual electricity-to-heat factors of ECMs in buildings are computed and their impact on system efficiency and greenhouse gas emissions of a Swedish biomass fuelled and combined heat and power utilising DHS are assessed. A weather normalising method for the DHS heat load is developed, combining segmented multivariable linear regressions with typical meteorological year weather data to enable the DHS model and the buildings model to work under the same weather conditions. Improving the buildings’ envelope insulation level and thereby levelling out the DHS heat load curve reduces greenhouse gas emissions and improves primary energy efficiency. Reducing household electricity use proves to be highly beneficial, partly because it increases heat demand, allowing for more cogeneration of electricity. However the other ECMs considered may cause increased greenhouse gas emissions, mainly because of their adverse impact on the cogeneration of electricity. If biomass fuels are considered as residuals, and thus assigned low primary energy factors, primary energy efficiency decreases when implementing ECMs that lower heat demand.

  14. [Self-rating of oral health according to the Oral Health Impact Profile and associated factors: a systematic review].

    Science.gov (United States)

    Gabardo, Marilisa Carneiro Leão; Moysés, Simone Tetu; Moysés, Samuel Jorge

    2013-06-01

    To systematically evaluate the literature to investigate associations between social, demographic, economic, psychosocial, and behavioral factors and the self-perception of oral health measured using the Oral Health Impact Profile (OHIP). In this systematic review of the literature, the Preferred Reporting Items for Systematic Reviews (PRISMA) were adapted for the performance of a qualitative metasummary, without meta-analysis. Articles about oral health and associated factors with implications for quality of life were selected, with a focus on the tool for self-rating of the oral health-disease process, the OHIP. Pubmed/National Library of Medicine (NLM) and the Virtual Health Library (Biblioteca Virtual em Saúde - BVS/BIREME) were searched. Articles published between 2001 and 2011 were included. The following Medical Subject Headings (MeSH) were employed: oral health, quality of life, sickness impact profile, and socioeconomic factors. Of 57 articles identified, 20 met the inclusion criteria. The metasummary revealed that a poor self-perception of oral health was associated with unfavorable social, economic, demographic, and psychosocial factors, as well as with undesirable habits and poor clinical oral conditions. There is consensus in the literature about the influence of the investigated factors on the self-perception of oral health and on quality of life. The OHIP is an important aid for determining oral health needs and for developing strategies to control/reduce disease and promote oral health, with a consequent positive impact on quality of life.

  15. Regional profile, energy-impacted communities: Region VIII

    Energy Technology Data Exchange (ETDEWEB)

    None

    1979-03-01

    This report has data on population, administration, finance, housing, health and safety, human services, education, and water and sewage for 325 energy-impacted communities. A review of current and potential energy developments in the region shows over 900 energy resource impacts listed for the 325 impacted communities. Coal development represents over one-third of the developments listed. Communities reporting coal development are distributed as follows: Colorado (36), Montana (42), North Dakota (61), South Dakota (13), Utah (73), and Wyoming (35). Energy-conversion initiatives represent another high incidence of energy-resource impact, with uranium development following closely with 83 communities reporting uranium development impact in the region. These projections indicate continued development of regional energy resources to serve national energy requirements. The 325 impacted communities as reported: Colorado (46), Montana (73), North Dakota (62), South Dakota (21), Utah (80), and Wyoming (43) follow a distribution pattern similar to that of future projects which illustrates that no area of the region will escape the impacts of energy development. (ERA citation 04:041706)

  16. Simultaneous Conduction and Valence Band Quantization in Ultrashallow High-Density Doping Profiles in Semiconductors

    Science.gov (United States)

    Mazzola, F.; Wells, J. W.; Pakpour-Tabrizi, A. C.; Jackman, R. B.; Thiagarajan, B.; Hofmann, Ph.; Miwa, J. A.

    2018-01-01

    We demonstrate simultaneous quantization of conduction band (CB) and valence band (VB) states in silicon using ultrashallow, high-density, phosphorus doping profiles (so-called Si:P δ layers). We show that, in addition to the well-known quantization of CB states within the dopant plane, the confinement of VB-derived states between the subsurface P dopant layer and the Si surface gives rise to a simultaneous quantization of VB states in this narrow region. We also show that the VB quantization can be explained using a simple particle-in-a-box model, and that the number and energy separation of the quantized VB states depend on the depth of the P dopant layer beneath the Si surface. Since the quantized CB states do not show a strong dependence on the dopant depth (but rather on the dopant density), it is straightforward to exhibit control over the properties of the quantized CB and VB states independently of each other by choosing the dopant density and depth accordingly, thus offering new possibilities for engineering quantum matter.

  17. The Influence of an undergraduate scientific initiation programme onn the professional profile of new physicians

    Directory of Open Access Journals (Sweden)

    Raphael Joaquim Teles Cyrillo

    2010-09-01

    Full Text Available Introduction: This paper studies the influence of a Scientific Initiation Programme (SIP on the professional profile of new doctors from a Brazilian university. Aim and methods: Evaluate fifty-two new doctors divided into two groups matched by sex, age and academic performance and differing only in participation in the SIP. Professional and socioeconomic data were collected, including schooling of parents; average income before, during and after the medical course; current professional situation; results of exams for civil servant recruitment; and titles and degrees obtained after graduation. Results: Significant differences were found only in civil servant recruitment exam results (p = 0.0098 and in income after graduation (p = 0.02, which were both higher in the non-SIP group. Only one doctor got a M.Sc. degree after graduation, but many of them in both groups obtained technical titles, and had papers presented at congresses or published. Conclusions: Apparently, taking part in a SIP led to lower income and worse civil servant recruitment exam results. However, this may only reflect a transient phase in a long-term process. New research currently under way will answer this remaining question, now that more time has elapsed since graduation. Resumo: Introdução: Este trabalho estuda a influência de um programa de iniciação científica (PIC no perfil profissional de médicos recém-formados numa universidade pública brasileira. Objectivos e métodos: Avaliamos cinquenta e dois novos médicos arrolados em dois grupos pareados por sexo, idade e coeficiente de rendimento académico, diferindo apenas na sua participação no PIC. Dados acerca da situação profissional e socioeconómica foram obtidos, incluindo a escolaridade dos pais; a renda familiar média antes, durante e depois da realização do curso médico; a situação profissional actual; as aprovações em concurso público e os títulos e graus obtidos após a gradua

  18. A shift in emission time profiles of fossil fuel combustion due to energy transitions impacts source receptor matrices for air quality.

    Science.gov (United States)

    Hendriks, Carlijn; Kuenen, Jeroen; Kranenburg, Richard; Scholz, Yvonne; Schaap, Martijn

    2015-03-01

    Effective air pollution and short-lived climate forcer mitigation strategies can only be designed when the effect of emission reductions on pollutant concentrations and health and ecosystem impacts are quantified. Within integrated assessment modeling source-receptor relationships (SRRs) based on chemistry transport modeling are used to this end. Currently, these SRRs are made using invariant emission time profiles. The LOTOS-EUROS model equipped with a source attribution module was used to test this assumption for renewable energy scenarios. Renewable energy availability and thereby fossil fuel back up are strongly dependent on meteorological conditions. We have used the spatially and temporally explicit energy model REMix to derive time profiles for backup power generation. These time profiles were used in LOTOS-EUROS to investigate the effect of emission timing on air pollutant concentrations and SRRs. It is found that the effectiveness of emission reduction in the power sector is significantly lower when accounting for the shift in the way emissions are divided over the year and the correlation of emissions with synoptic situations. The source receptor relationships also changed significantly. This effect was found for both primary and secondary pollutants. Our results indicate that emission timing deserves explicit attention when assessing the impacts of system changes on air quality and climate forcing from short lived substances.

  19. Pattern and intensity of human impact on coral reefs depend on depth along the reef profile and on the descriptor adopted

    Science.gov (United States)

    Nepote, Ettore; Bianchi, Carlo Nike; Chiantore, Mariachiara; Morri, Carla; Montefalcone, Monica

    2016-09-01

    Coral reefs are threatened by multiple global and local disturbances. The Maldives, already heavily hit by the 1998 mass bleaching event, are currently affected also by growing tourism and coastal development that may add to global impacts. Most of the studies investigating effects of local disturbances on coral reefs assessed the response of communities along a horizontal distance from the impact source. This study investigated the status of a Maldivian coral reef around an island where an international touristic airport has been recently (2009-2011) built, at different depths along the reef profile (5-20 m depth) and considering the change in the percentage of cover of five different non-taxonomic descriptors assessed through underwater visual surveys: hard corals, soft corals, other invertebrates, macroalgae and abiotic attributes. Eight reefs in areas not affected by any coastal development were used as controls and showed a reduction of hard coral cover and an increase of abiotic attributes (i.e. sand, rock, coral rubble) at the impacted reef. However, hard coral cover, the most widely used descriptor of coral reef health, was not sufficient on its own to detect subtle indirect effects that occurred down the reef profile. Selecting an array of descriptors and considering different depths, where corals may find a refuge from climate impacts, could guide the efforts of minimising local human pressures on coral reefs.

  20. Development and validation of the Child Oral Health Impact Profile - Preschool version.

    Science.gov (United States)

    Ruff, R R; Sischo, L; Chinn, C H; Broder, H L

    2017-09-01

    The Child Oral Health Impact Profile (COHIP) is a validated instrument created to measure the oral health-related quality of life of school-aged children. The purpose of this study was to develop and validate a preschool version of the COHIP (COHIP-PS) for children aged 2-5. The COHIP-PS was developed and validated using a multi-stage process consisting of item selection, face validity testing, item impact testing, reliability and validity testing, and factor analysis. A cross-sectional convenience sample of caregivers having children 2-5 years old from four groups completed item clarity and impact forms. Groups were recruited from pediatric health clinics or preschools/daycare centers, speech clinics, dental clinics, or cleft/craniofacial centers. Participants had a variety of oral health-related conditions, including caries, congenital orofacial anomalies, and speech/language deficiencies such as articulation and language disorders. COHIP-PS. The COHIP-PS was found to have acceptable internal validity (a = 0.71) and high test-retest reliability (0.87), though internal validity was below the accepted threshold for the community sample. While discriminant validity results indicated significant differences across study groups, the overall magnitude of differences was modest. Results from confirmatory factor analyses support the use of a four-factor model consisting of 11 items across oral health, functional well-being, social-emotional well-being, and self-image domains. Quality of life is an integral factor in understanding and assessing children's well-being. The COHIP-PS is a validated oral health-related quality of life measure for preschool children with cleft or other oral conditions. Copyright© 2017 Dennis Barber Ltd.

  1. Fabrication of a novel silicon single electron transistor for Si:P quantum computer devices

    International Nuclear Information System (INIS)

    Angus, S.J.; Smith, C.E.A.; Gauja, E.; Dzurak, A.S.; Clark, R.G.; Snider, G.L.

    2004-01-01

    Full text: Quantum computation relies on the successful measurement of quantum states. Single electron transistors (SETs) are known to be able to perform fast and sensitive charge measurements of solid state qubits. However, due to their sensitivity, SETs are also very susceptible to random charge fluctuations in a solid-state materials environment. In previous dc transport measurements, silicon-based SETs have demonstrated greater charge stability than A1/A1 2 O 3 SETs. We have designed and fabricated a novel silicon SET architecture for a comparison of the noise characteristics of silicon and aluminium based devices. The silicon SET described here is designed for controllable and reproducible low temperature operation. It is fabricated using a novel dual gate structure on a silicon-on-insulator substrate. A silicon quantum wire is formed in a 100nm thick high-resistivity superficial silicon layer using reactive ion etching. Carriers are induced in the silicon wire by a back gate in the silicon substrate. The tunnel barriers are created electrostatically, using lithographically defined metallic electrodes (∼40nm width). These tunnel barriers surround the surface of the quantum wire, thus producing excellent electrostatic confinement. This architecture provides independent control of tunnel barrier height and island occupancy, thus promising better control of Coulomb blockade oscillations than in previously investigated silicon SETs. The use of a near intrinsic silicon substrate offers compatibility with Si:P qubits in the longer term

  2. Clinical impact of extensive molecular profiling in advanced cancer patients

    Directory of Open Access Journals (Sweden)

    Sophie Cousin

    2017-02-01

    Full Text Available Abstract Previous precision medicine studies have investigated conventional molecular techniques and/or limited sets of gene alterations. The aim of this study was to describe the impact of the next-generation sequencing of the largest panel of genes used to date in tumour tissue and blood in the context of institutional molecular screening programmes. DNA analysis was performed by next-generation sequencing using a panel of 426 cancer-related genes and by comparative genomic hybridization from formalin-fixed and paraffin-embedded archived tumour samples when available or from fresh tumour samples. Five hundred sixty-eight patients were enrolled. The median number of prior lines of treatment was 2 (range 0–9. The most common primary tumour types were lung (16.9%, colorectal (14.4%, breast (10.6%, ovarian (10.2% and sarcoma (10.2%. The median patient age was 63 years (range 19–88. A total of 292 patients (51.4% presented with at least one actionable genetic alteration. The 20 genes most frequently altered were TP53, CDKN2A, KRAS, PTEN, PI3KCA, RB1, APC, ERBB2, MYC, EGFR, CDKN2B, ARID1A, SMAD4, FGFR1, MDM2, BRAF, ATM, CCNE1, FGFR3 and FRS2. One hundred fifty-nine patients (28% were included in early phase trials. The treatment was matched with a tumour profile in 86 cases (15%. The two main reasons for non-inclusion were non-progressive disease (31.5% and general status deterioration (25%. Twenty-eight percent of patients presented with a growth modulation index (time to progression under the early phase trial treatment/time to progression of the previous line of treatment >1.3. Extensive molecular profiling using high-throughput techniques allows for the identification of actionable mutations in the majority of cases and is associated with substantial clinical benefit in up to one in four patients.

  3. Transcriptional profiling avian beta-defensins in chicken oviduct epithelial cells before and after infection with Salmonella enterica serovar Enteritidis

    Directory of Open Access Journals (Sweden)

    Bailey R Hartford

    2009-07-01

    Full Text Available Abstract Background Salmonella enterica serovar Enteritidis (SE colonizes the ovary and oviduct of chickens without causing overt clinical signs which can lead to SE-contamination of the content and membrane of shell-eggs as well as hatchery eggs. The organism utilizes the Salmonella Pathogenicity Island-2 encoded type III secretion system (T3SS-2 to promote persistence in the oviduct of laying hens. In this study, reverse transcriptase-polymerase chain reaction (RT-PCR was carried out to determine the expression profiles of 14 known avian beta defensins (AvBDs in primary chicken oviduct epithelial cells (COEC before and after infections with a wild type SE strain and T3SS mutant SE strains carrying an inactivated sipA or pipB gene. Results Based on the expression levels in uninfected COEC, AvBDs can be loosely grouped into three categories with AvBD4-5 and AvBD9-12 being constitutively expressed at high levels; AvBD1, AvBD3, and AvBD13-14 at moderate levels; and AvBD2 and AvBD6-8 at minimal levels. Infection with the wild type SE strain temporarily repressed certain highly expressed AvBDs and induced the expression of minimally expressed AvBDs. The pipB mutant, compared to the wild type strain, had reduced suppressive effect on the expression of highly expressed AvBDs. Moreover, the pipB mutant elicited significantly higher levels of the minimally expressed AvBDs than the wild type SE or the sipA mutant did. Conclusion Chicken oviduct epithelial cells express most of the known AvBD genes in response to SE infection. PipB, a T3SS-2 effector protein, plays a role in dampening the β-defensin arm of innate immunity during SE invasion of chicken oviduct epithelium.

  4. Transcriptional profiling avian beta-defensins in chicken oviduct epithelial cells before and after infection with Salmonella enterica serovar Enteritidis.

    Science.gov (United States)

    Ebers, Katie L; Zhang, C Yan; Zhang, M Zhenyu; Bailey, R Hartford; Zhang, Shuping

    2009-07-30

    Salmonella enterica serovar Enteritidis (SE) colonizes the ovary and oviduct of chickens without causing overt clinical signs which can lead to SE-contamination of the content and membrane of shell-eggs as well as hatchery eggs. The organism utilizes the Salmonella Pathogenicity Island-2 encoded type III secretion system (T3SS-2) to promote persistence in the oviduct of laying hens. In this study, reverse transcriptase-polymerase chain reaction (RT-PCR) was carried out to determine the expression profiles of 14 known avian beta defensins (AvBDs) in primary chicken oviduct epithelial cells (COEC) before and after infections with a wild type SE strain and T3SS mutant SE strains carrying an inactivated sipA or pipB gene. Based on the expression levels in uninfected COEC, AvBDs can be loosely grouped into three categories with AvBD4-5 and AvBD9-12 being constitutively expressed at high levels; AvBD1, AvBD3, and AvBD13-14 at moderate levels; and AvBD2 and AvBD6-8 at minimal levels. Infection with the wild type SE strain temporarily repressed certain highly expressed AvBDs and induced the expression of minimally expressed AvBDs. The pipB mutant, compared to the wild type strain, had reduced suppressive effect on the expression of highly expressed AvBDs. Moreover, the pipB mutant elicited significantly higher levels of the minimally expressed AvBDs than the wild type SE or the sipA mutant did. Chicken oviduct epithelial cells express most of the known AvBD genes in response to SE infection. PipB, a T3SS-2 effector protein, plays a role in dampening the beta-defensin arm of innate immunity during SE invasion of chicken oviduct epithelium.

  5. Development and preclinical evaluation of new 124I-folate conjugates for PET imaging of folate receptor-positive tumors

    International Nuclear Information System (INIS)

    AlJammaz, I.; Al-Otaibi, B.; Al-Rumayan, F.; Al-Yanbawi, S.; Amer, S.; Okarvi, S.M.

    2014-01-01

    In an attempt to develop new folate radiotracers with favorable biochemical properties for detecting folate receptor-positive cancers, we have synthesized [ 124 I]-SIB- and [ 124 I]-SIP-folate conjugates using a straightforward and two-step simple reactions. Radiochemical yields for [ 124 I]-SIB- and [ 124 I]-SIP-folate conjugates were greater than 90 and 60% respectively, with total synthesis time of 30–40 min. Radiochemical purities were always greater than 98% without HPLC purification. These synthetic approaches hold considerable promise as rapid and simple method for 124 I-folate conjugate preparation with high radiochemical yield in short synthesis time. In vitro tests on KB cell line showed that the significant amounts of the radioconjugates were associated with cell fractions. In vivo characterization in normal Balb/c mice revealed rapid blood clearance of these radioconjugates and favorable biodistribution profile for [ 124 I]-SIP-folate conjugate over [ 124 I]-SIB-folate conjugate. Biodistribution studies of [ 124 I]-SIP-folate conjugate in nude mice bearing human KB cell line xenografts, demonstrated significant tumor uptake. The uptake in the tumors was blocked by excess injection of folic acid, suggesting a receptor-mediated process. These results demonstrate that [ 124 I]-SIP-folate conjugate may be useful as a molecular probe for detecting and staging of folate receptor-positive cancers, such as ovarian cancer and their metastasis as well as monitoring tumor response to treatment

  6. Stability and change in teachers' goal orientation profiles over time : Managerial coaching behavior as a predictor of profile change

    NARCIS (Netherlands)

    Kunst, E.M.; van Woerkom, M.; van Kollenburg, G.H.; Poell, R.F.

    2018-01-01

    Goal orientation is an important predictor of motivation at work. This study introduces goal orientation profiles in the work domain, evaluates their stability over time and assesses the impact of managerial coaching behavior on change in employees' goal orientation profiles. We hypothesize that

  7. The internal responsiveness of the Oral Health Impact Profile-14 to detect differences in clinical parameters related to surgical third molar removal

    NARCIS (Netherlands)

    Kieffer, J. M.; van Wijk, A. J.; Ho, J. P.; Lindeboom, J. A. H.

    2012-01-01

    Purpose The present study examined the internal responsiveness of the short-form Oral Health Impact Profile (OHIP-14) and its ability to differentiate between patients with and without pre- and postoperative complaints as well as other clinical variables. Methods The sample consisted of 97 patients

  8. Induced Polarization Signature of Biofilms in Porous Media: From Laboratory Experiments to Theoretical Developments and Validation

    Energy Technology Data Exchange (ETDEWEB)

    Atekwana, Estella [Oklahoma State Univ., Stillwater, OK (United States); Patrauchan, Marianna [Oklahoma State Univ., Stillwater, OK (United States); Revil, Andre [Colorado School of Mines, Golden, CO (United States)

    2016-10-04

    Bioremediation strategies for mitigating the transport of heavy metals and radionuclides in subsurface sediments have largely targeted the use of dissimilatory metal and sulfate-reducing bacteria. Growth and metabolic activities from these organisms can significantly influence biogeochemical processes, including mineral dissolution/precipitation, fluctuating pH and redox potential (Eh) values, development of biofilms, and decreasing hydraulic conductivity. The Spectral Induced Polarization (SIP) technique has emerged as the technique most sensitive to the presence of microbial cells and biofilms in porous media; yet it is often difficult to unambiguously distinguish the impact of multiple and often competing processes that occur during in-situ biostimulation activities on the SIP signatures. The main goal of our project is to quantitatively characterize major components within bacterial biofilms (cells, DNA, metals, metabolites etc.) contributing to detectable SIP signatures. We specifically: (i) evaluated the contribution of biofilm components to SIP signatures, (ii) determined the contribution of biogenic minerals commonly found in biofilms to SIP signatures, (iii) determined if the SIP signatures can be used to quantify the rates of biofilm formation, (iv) developed models and a fundamental understanding of potential underlying polarization mechanisms at low frequencies (<40 kHz) resulting from the presence of microbial cells and biofilms

  9. Polysome Profile Analysis - Yeast

    Czech Academy of Sciences Publication Activity Database

    Pospíšek, M.; Valášek, Leoš Shivaya

    2013-01-01

    Roč. 530, č. 2013 (2013), s. 173-181 ISSN 0076-6879 Institutional support: RVO:61388971 Keywords : grow yeast cultures * polysome profile analysis * sucrose density gradient centrifugation Subject RIV: CE - Biochemistry Impact factor: 2.194, year: 2013

  10. Measuring the impact and distress of health problems from the individual's perspective: development of the Perceived Impact of Problem Profile (PIPP)

    Science.gov (United States)

    Pallant, Julie F; Misajon, RoseAnne; Bennett, Elizabeth; Manderson, Lenore

    2006-01-01

    Background The aim of this study was to develop and conduct preliminary validation of the Perceived Impact of Problem Profile (PIPP). Based on the biopsychosocial model of health and functioning, the PIPP was intended as a generic research and clinical measurement tool to assess the impact and distress of health conditions from the individuals' perspective. The ICF classification system was used to guide the structure of the PIPP with subscales included to assess impact on self-care, mobility, participation, relationships and psychological well-being. While the ICF focuses on the classification of objective health and health related status, the PIPP broadens this focus to address the individuals' subjective experience of their health condition. Methods An item pool of 23 items assessing both impact and distress on five key domains was generated. These were administered to 169 adults with mobility impairment. Rasch analysis using RUMM2020 was conducted to assess the psychometric properties of each set of items. Preliminary construct validation of the PIPP was performed using the EQ5D. Results For both the Impact and Distress scales of the PIPP, the five subscales (Self-care, Mobility, Participation, Relationships, and Psychological Well-being) showed adequate psychometric properties, demonstrating fit to the Rasch model. All subscales showed adequate person separation reliability and no evidence of differential item functioning for sex, age, educational level or rural vs urban residence. Preliminary validity testing using the EQ5D items provided support for the subscales. Conclusion This preliminary study, using a sample of adults with mobility impairment, provides support for the psychometric properties of the PIPP as a potential clinical and research measurement tool. The PIPP provides a brief, but comprehensive means to assess the key ICF components, focusing on the individuals' perspective of the impact and distress caused by their health condition. Further

  11. Measuring the impact and distress of health problems from the individual's perspective: development of the Perceived Impact of Problem Profile (PIPP

    Directory of Open Access Journals (Sweden)

    Bennett Elizabeth

    2006-06-01

    Full Text Available Abstract Background The aim of this study was to develop and conduct preliminary validation of the Perceived Impact of Problem Profile (PIPP. Based on the biopsychosocial model of health and functioning, the PIPP was intended as a generic research and clinical measurement tool to assess the impact and distress of health conditions from the individuals' perspective. The ICF classification system was used to guide the structure of the PIPP with subscales included to assess impact on self-care, mobility, participation, relationships and psychological well-being. While the ICF focuses on the classification of objective health and health related status, the PIPP broadens this focus to address the individuals' subjective experience of their health condition. Methods An item pool of 23 items assessing both impact and distress on five key domains was generated. These were administered to 169 adults with mobility impairment. Rasch analysis using RUMM2020 was conducted to assess the psychometric properties of each set of items. Preliminary construct validation of the PIPP was performed using the EQ5D. Results For both the Impact and Distress scales of the PIPP, the five subscales (Self-care, Mobility, Participation, Relationships, and Psychological Well-being showed adequate psychometric properties, demonstrating fit to the Rasch model. All subscales showed adequate person separation reliability and no evidence of differential item functioning for sex, age, educational level or rural vs urban residence. Preliminary validity testing using the EQ5D items provided support for the subscales. Conclusion This preliminary study, using a sample of adults with mobility impairment, provides support for the psychometric properties of the PIPP as a potential clinical and research measurement tool. The PIPP provides a brief, but comprehensive means to assess the key ICF components, focusing on the individuals' perspective of the impact and distress caused by their

  12. Recherche chronologique sur la culture mochica du Pérou : datation de la tombe du Prêtre de Sipán par thermoluminescence (TL) et par radiocarbone

    OpenAIRE

    Roque, Céline; Vartanian, Emmanuel; Guibert, Pierre; Schvoerer, Max; Lévine, Daniel; Alva, Walter; Jungner, Hogne

    2007-01-01

    La culture mochica du Pérou et le site de Sipán : problématique chronologiqueDe l’importance des recherches chronologiques sur la culture mochica du PérouLa culture Moche, ou mochica, est sans doute l’une des plus brillantes de l’époque pré-Inca. Elle s’épanouit sur la côte nord du Pérou, parallèlement aux civilisations Paracas Nécropolis et Nasca, qui se développent sur la côte sud du pays. Elle marque l’apogée d’un art particulièrement raffiné qui se manifeste notamment à travers l’orfèvrer...

  13. Load profiles analysis for electricity market

    Directory of Open Access Journals (Sweden)

    Radu Porumb

    2014-04-01

    Full Text Available In the wake of electric power system transition towards smart grids, and the adoption of the electric market schemes, electric utilities are facing the need of a better load profiles understanding for their customers. In this work, some key objectives were addresses, such as definition of the mathematical model for calculating the hourly energy specific, identification of the three target groups for users who have developed consumer profiles, definition of the two types of significant load and assessment of the impact of using consumer profiles on users.

  14. Response of temperature and density profiles to heat deposition profile and its impact on global scaling in LHD

    International Nuclear Information System (INIS)

    Yamada, H.

    2002-01-01

    Significant density dependence of the energy confinement time as described in the ISS95 scaling has been demonstrated in the extended parameter regimes in LHD. However, recent experiments have indicated that this density dependence is lost at a certain density under specific conditions. This paper discusses the cause of this saturation and related characteristics of anomalous transport. The saturation of the energy confinement time is observed in the density ramp-up phase of NBI heated plasmas. In contrast to the global energy confinement time, the local heat conduction coefficient still indicates the temperature dependence which is a companion to the density dependence of the energy confinement time. The apparent contradiction between the global confinement and the local transport can be attributed to the change of the heat deposition profile. Through this study, the response of temperature and density profiles to the heat deposition profile is highlighted, which is contrasted to the concept of stiffness or profile consistency observed in tokamaks. The major anomalous transport models based on ITG/TEM and interchange/ballooning modes are assessed. (author)

  15. Study on the impact of industrial flue gases on the PCDD/Fs congener profile in ambient air.

    Science.gov (United States)

    Węgiel, Małgorzata; Chrząszcz, Ryszard; Maślanka, Anna; Grochowalski, Adam

    2014-11-01

    The aim of this study was to examine the impact of emissions from combustion processes from sinter, medical, waste and sewage waste incineration plants on the PCDD and PCDF congener profile in ambient air in Krakow (city in Poland). The subject matter of the study were air samples from the outskirts and the city center. It was found that in flue gases from industrial sources and in ambient air the share of PCDF congeners in relation to the total content of PCDD/Fs was higher than the share of PCDDs. However, in air samples collected in the city center, this relationship was reversed. The PCDD congener profiles in flue gases and in air samples are comparable. However, in the samples from the city centre, the share of OCDD is significantly higher and amounts to about 80%. The PCDF congener shares show higher spatial diversity, although in all the analyzed air samples, ODCF and 1,2,3,4,6,7,8 HpCDF dominated. Analyzing the share of congeners in regard to the sum of PCDDs/Fs a mutual resemblance of air from the suburbs, exhaust gases from the sinter ore and sewage sludge incinerator plant was observed. The study showed a similarity between the profile of congeners in air from the city centre and exhaust gases from the medical waste incinerator. Copyright © 2014 Elsevier Ltd. All rights reserved.

  16. Determination of the stability of the uranyl ion sipped in τ-hydrogen phosphate of zirconium in sodic form

    International Nuclear Information System (INIS)

    Ordonez R, E.; Fernandez V, S.M.; Drot, R.; Simoni, E.

    2005-01-01

    The stability of the uranyl sipped in the zirconium τ-hydrogen phosphate in sodic form (τ-NaZrP), was carried out characterizing the complexes formed by Laser spectroscopy in the visible region and by X-ray photoelectron spectroscopy. The material was prepared by a new synthesis technique working in nitrogen atmosphere and to low temperatures. The sorption of the uranyl ion was made in acid media with concentrations of 10 -4 and 10 -5 of uranyl nitrate and with ion forces of 0.1 and 0.5 M of NaClO 4 . The spectra of induced fluorescence with laser (TRLFS) show that the uranyl is fixed in very acid media in three well differentiated species, to pH less acid, the specie of long half life disappears and are only those of short half life. The results of the binding energy obtained by XPS indicate that the binding energy of the uranyl confer it a stable character to the complex formed in the τ-NaZP, that makes to this material appropriate to retain to the uranyl in solution to high ion forces and in acid media. (Author)

  17. Privatization and Financial Market Development: Theoretical Issues

    OpenAIRE

    Gabriella Chiesa; Giovanna Nicodano

    2003-01-01

    Stock market capitalization in developed countries grew while massive privatization plans were in progress. It is however possible that stock market development would have occurred anyway. Below we identify features that are specific to share-issue privatizations (SIPs) and should a priori impact on market liquidity and market size. A positive correlation between such features and market development in a cross section of countries would support the claim that certain types of SIPs contribute ...

  18. Country profile: Hungary

    Energy Technology Data Exchange (ETDEWEB)

    1991-09-01

    Country Profile: Hungary has been prepared as a background document for use by US Government agencies and US businesses interested in becoming involved with the new democracies of Eastern Europe as they pursue sustainable economic development. The focus of the Profile is on energy and highlights information on Hungary`s energy supply, demand, and utilization. It identifies patterns of energy usage in the important economic sectors, especially industry, and provides a preliminary assessment for opportunities to improve efficiencies in energy production, distribution and use by introducing more efficient technologies. The use of more efficient technologies would have the added benefit of reducing the environmental impact which, although is not the focus of the report, is an issue that effects energy choices. The Profile also presents considerable economic information, primarily in the context of how economic restructuring may affect energy supply, demand, and the introduction of more efficient technologies.

  19. Country profile: Hungary

    Energy Technology Data Exchange (ETDEWEB)

    1991-09-01

    Country Profile: Hungary has been prepared as a background document for use by US Government agencies and US businesses interested in becoming involved with the new democracies of Eastern Europe as they pursue sustainable economic development. The focus of the Profile is on energy and highlights information on Hungary's energy supply, demand, and utilization. It identifies patterns of energy usage in the important economic sectors, especially industry, and provides a preliminary assessment for opportunities to improve efficiencies in energy production, distribution and use by introducing more efficient technologies. The use of more efficient technologies would have the added benefit of reducing the environmental impact which, although is not the focus of the report, is an issue that effects energy choices. The Profile also presents considerable economic information, primarily in the context of how economic restructuring may affect energy supply, demand, and the introduction of more efficient technologies.

  20. The Impact of a Performance Profiling Intervention on Athletes' Intrinsic Motivation

    Science.gov (United States)

    Weston, Neil J. V.; Greenlees, Iain A.; Thelwell, Richard C.

    2011-01-01

    Originally developed by Butler (1989) with the Great Britain Olympic boxing team, performance profiling is an assessment tool primarily used by sport psychologists to enhance athlete awareness. The completed profile provides the athlete, the coach, and psychologist with a visual representation of the athlete's perception of his or her performance…

  1. A Novel Protocol Proposal for Integratıon of SIP Based Telephony Services To IPTV System

    Directory of Open Access Journals (Sweden)

    Hasan YÜKSELTEN

    2011-04-01

    Full Text Available Bu çalışmada, oturum başlatma protokolü (SIP tabanlı çağrı sunucusuyla sağlanan telefon servislerinin IPTV sistemiyle bütünleşmesini sağlayacak yeni bir mimari yapı önerilmiş ve bu amaca yönelik yeni bir protokol (Bağımsız Bildirim Protokolü tasarlanarak geliştirilen mimari yapının avantajları incelenmiştir. Önerilen mimari yapı ve bunu destekleyen protokoller, bildirim mimarisinde arabirim katmanına (middleware olan gereksinimi ortadan kaldırmaktadır. Böylece, bildirim mimari yapısı bir katman azaltılmakta, arabirim katmanına olan bağımlılık sona ermekte, her türlü arabirim katmanı ile bildirim mimarisi kurulabilmektedir. Geliştirilen mimari yapı ve protokolün testleri sonucunda, bildirim bant genişliğinin, mevcut bildirim mimari yapılarındakinin %10’una kadar düştüğü ve önerilen mimari yapının başarılı bir şekilde çalıştığı görülmüştür.

  2. Suppressing segregation in highly phosphorus doped silicon monolayers

    NARCIS (Netherlands)

    Keizer, Joris; Kölling, Sebastian; Koenraad, Paul; Simmons, Michelle Y.

    2015-01-01

    Sharply defined dopant profiles and low resistivity are highly desired qualities in the microelectronic industry, and more recently, in the development of an all epitaxial Si:P based quantum computer. In this work, we use thin (monolayers thick) room temperature grown silicon layers, so-called

  3. Spanish version of the Oral Health Impact Profile (OHIP-Sp

    Directory of Open Access Journals (Sweden)

    Baelum Vibeke

    2006-07-01

    Full Text Available Abstract Background The need for appraisal of oral health-related quality of life has been increasingly recognized over the last decades. The aims of this study were to develop a Spanish version (OHIP-Sp of the Oral Health Impact Profile and to evaluate its convergent and discriminative validity, and its internal consistency. Methods The original 49-items OHIP was translated to Spanish, revised for understanding and semantics by two independent dentists, and then translated back to English by an independent bilingual dentist. The data originated in a cross sectional study conducted among high school students from the Province of Santiago, Chile. The study group was sampled using a multistage random cluster procedure yielding 9,203 students aged 12–21 years. All selected students were invited to participate and all filled a questionnaire with information on socio-demographic factors; oral health related behaviors; and self-reported oral health status (good, fair or poor. From this group, 9,163 students also accepted to fill a detailed questionnaire on socio-economic indicators and to receive a clinical examination comprising direct recordings of clinical attachment levels (CAL in molars and incisors, tooth loss, and the presence of necrotizing ulcerative gingival lesions. Results The participation rate and the questionnaire completeness were high with OHIP-Sp total scores being computed for 9,133 subjects. Self-perceived oral health status was associated with the total OHIP-Sp score and all its domains (Spearman rank correlation. The OHIP-Sp total score was also directly associated with the 4 dental outcomes investigated (Mann-Whitney test and the largest impact was found for the outcomes, 'tooth loss' with a mean OHIP-Sp score = 13.5 and 'CAL >= 3 mm' with a mean OHIP-Sp score = 13.0. Conclusion The OHIP-Sp revealed suitable convergent and discriminative validity and appropriate internal consistency (Cronbach's α. Further studies on OHIP

  4. The cytokine temporal profile in rat cortex after controlled cortical impact.

    Science.gov (United States)

    Dalgard, Clifton L; Cole, Jeffrey T; Kean, William S; Lucky, Jessica J; Sukumar, Gauthaman; McMullen, David C; Pollard, Harvey B; Watson, William D

    2012-01-01

    Cerebral inflammatory responses may initiate secondary cascades following traumatic brain injury (TBI). Changes in the expression of both cytokines and chemokines may activate, regulate, and recruit innate and adaptive immune cells associated with secondary degeneration, as well as alter a host of other cellular processes. In this study, we quantified the temporal expression of a large set of inflammatory mediators in rat cortical tissue after brain injury. Following a controlled cortical impact (CCI) on young adult male rats, cortical and hippocampal tissue of the injured hemisphere and matching contralateral material was harvested at early (4, 12, and 24 hours) and extended (3 and 7 days) time points post-procedure. Naïve rats that received only anesthesia were used as controls. Processed brain homogenates were assayed for chemokine and cytokine levels utilizing an electrochemiluminescence-based multiplex ELISA platform. The temporal profile of cortical tissue samples revealed a multi-phasic injury response following brain injury. CXCL1, IFN-γ, TNF-α levels significantly peaked at four hours post-injury compared to levels found in naïve or contralateral tissue. CXCL1, IFN-γ, and TNF-α levels were then observed to decrease at least 3-fold by 12 hours post-injury. IL-1β, IL-4, and IL-13 levels were also significantly elevated at four hours post-injury although their expression did not decrease more than 3-fold for up to 24 hours post-injury. Additionally, IL-1β and IL-4 levels displayed a biphasic temporal profile in response to injury, which may suggest their involvement in adaptive immune responses. Interestingly, peak levels of CCL2 and CCL20 were not observed until after four hours post-injury. CCL2 levels in injured cortical tissue were significantly higher than peak levels of any other inflammatory mediator measured, thus suggesting a possible use as a biomarker. Fully elucidating chemokine and cytokine signaling properties after brain injury may

  5. Computational methods using weighed-extreme learning machine to predict protein self-interactions with protein evolutionary information.

    Science.gov (United States)

    An, Ji-Yong; Zhang, Lei; Zhou, Yong; Zhao, Yu-Jun; Wang, Da-Fu

    2017-08-18

    Self-interactions Proteins (SIPs) is important for their biological activity owing to the inherent interaction amongst their secondary structures or domains. However, due to the limitations of experimental Self-interactions detection, one major challenge in the study of prediction SIPs is how to exploit computational approaches for SIPs detection based on evolutionary information contained protein sequence. In the work, we presented a novel computational approach named WELM-LAG, which combined the Weighed-Extreme Learning Machine (WELM) classifier with Local Average Group (LAG) to predict SIPs based on protein sequence. The major improvement of our method lies in presenting an effective feature extraction method used to represent candidate Self-interactions proteins by exploring the evolutionary information embedded in PSI-BLAST-constructed position specific scoring matrix (PSSM); and then employing a reliable and robust WELM classifier to carry out classification. In addition, the Principal Component Analysis (PCA) approach is used to reduce the impact of noise. The WELM-LAG method gave very high average accuracies of 92.94 and 96.74% on yeast and human datasets, respectively. Meanwhile, we compared it with the state-of-the-art support vector machine (SVM) classifier and other existing methods on human and yeast datasets, respectively. Comparative results indicated that our approach is very promising and may provide a cost-effective alternative for predicting SIPs. In addition, we developed a freely available web server called WELM-LAG-SIPs to predict SIPs. The web server is available at http://219.219.62.123:8888/WELMLAG/ .

  6. The impact of kitchen and food service preparation practices on the volatile aroma profile in ripe tomatoes: Effects of refrigeration and blanching

    Science.gov (United States)

    Both refrigeration and blanching of red stage tomatoes are common practices in Japan home kitchens and in food service operations. However, little is reported on the impact of such practices on aroma profiles in tomato fruits. In this study, ‘FL 47’ tomatoes at red stage were dipped in 50 °C hot wat...

  7. LCA profiles for building components:

    DEFF Research Database (Denmark)

    Marsh, Rob

    2016-01-01

    . A full bivariate linear regression analysis is performed, showing statistically significant correlations with strong direct relationships between environmental impact categories. A simplified LCA profile consisting of total primary energy, global warming potential and acidification potential is developed...

  8. Identification of glucose-fermenting bacteria present in an in-vitro model of the human inetstine by RNA-stable isotope probing

    NARCIS (Netherlands)

    Egert, M.G.G.; Graaf, de A.A.; Maathuis, A.; Waard, de P.; Plugge, C.M.; Smidt, H.; Deutz, N.E.P.; Dijkema, C.; Vos, de W.M.; Venema, K.

    2007-01-01

    16S rRNA-based stable isotope probing (SIP) and nuclear magnetic resonance (NMR) spectroscopy-based metabolic profiling were used to identify bacteria fermenting glucose under conditions simulating the human intestine. The TIM-2 in vitro model of the human intestine was inoculated with a GI tract

  9. Identification of glucose-fermenting bacteria present in an in vitro model of the human intestine by RNA-stable isotope probing

    NARCIS (Netherlands)

    Egert, M.; Graaf, A.A. de; Maathuis, A.; Waard, P. de; Plugge, C.M.; Smidt, H.; Deutz, N.E.P.; Dijkema, C.; Vos, W.M. de; Venema, K.

    2007-01-01

    16S rRNA-based stable isotope probing (SIP) and nuclear magnetic resonance (NMR) spectroscopy-based metabolic profiling were used to identify bacteria fermenting glucose under conditions simulating the human intestine. The TIM-2 in vitro model of the human intestine was inoculated with a GI tract

  10. Metabolite Profiling of Red Sea Corals

    KAUST Repository

    Ortega, Jovhana Alejandra

    2016-01-01

    that provide insights into the specific nature of the symbiosis. Our analysis also revealed aquatic pollutants, which suggests that metabolite profiling might be used for monitoring pollution levels and assessing environmental impact.

  11. Psychosocial work factors and first depressive episode: retrospective results from the French national SIP survey.

    Science.gov (United States)

    Niedhammer, Isabelle; Chastang, Jean-François

    2015-10-01

    The objective was to explore the associations between psychosocial work factors and first depressive episode. Additional objectives included the study of the frequency and duration of exposure, and the evaluation of the induction period between exposures and outcome and of the reversibility of the effects. The study was based on a sample of 13,648 men and women from the 2006 national representative French SIP survey. Retrospective evaluation was performed for depressive episode for the whole life history, for psychological demands, skill discretion, social support, tension with the public, reward and work-life imbalance for each job, and within each job before and after each major change, and for time-varying covariates. The outcome was the first depressive episode. Statistical analysis was performed using weighted discrete time logistic regression model. High psychological demands and low social support were risk factors for first depressive episode for both genders. The risk increased with the frequency of exposure to these factors. Associations were found with the frequency of exposure to tension with the public among women and to work-life imbalance among men. The risk increased with the duration of exposure to psychological demands and low social support for both genders, however, these associations become non-significant when recent exposure was taken into account. Past exposure older than 2 years was not associated with the outcome. Associations between psychosocial work factors and first depressive episode were observed, including dose-response associations. However, after removal of the exposure, the risk may be reduced after 2 years.

  12. Suppression of CCR impacts metabolite profile and cell wall composition in Pinus radiata tracheary elements.

    Science.gov (United States)

    Wagner, Armin; Tobimatsu, Yuki; Goeminne, Geert; Phillips, Lorelle; Flint, Heather; Steward, Diane; Torr, Kirk; Donaldson, Lloyd; Boerjan, Wout; Ralph, John

    2013-01-01

    Suppression of the lignin-related gene cinnamoyl-CoA reductase (CCR) in the Pinus radiata tracheary element (TE) system impacted both the metabolite profile and the cell wall matrix in CCR-RNAi lines. UPLC-MS/MS-based metabolite profiling identified elevated levels of p-coumaroyl hexose, caffeic acid hexoside and ferulic acid hexoside in CCR-RNAi lines, indicating a redirection of metabolite flow within phenylpropanoid metabolism. Dilignols derived from coniferyl alcohol such as G(8-5)G, G(8-O-4)G and isodihydrodehydrodiconiferyl alcohol (IDDDC) were substantially depleted, providing evidence for CCR's involvement in coniferyl alcohol biosynthesis. Severe CCR suppression almost halved lignin content in TEs based on a depletion of both H-type and G-type lignin, providing evidence for CCR's involvement in the biosynthesis of both lignin types. 2D-NMR studies revealed minor changes in the H:G-ratio and consequently a largely unchanged interunit linkage distribution in the lignin polymer. However, unusual cell wall components including ferulate and unsaturated fatty acids were identified in TEs by thioacidolysis, pyrolysis-GC/MS and/or 2D-NMR in CCR-RNAi lines, providing new insights into the consequences of CCR suppression in pine. Interestingly, CCR suppression substantially promoted pyrolytic breakdown of cell wall polysaccharides, a phenotype most likely caused by the incorporation of acidic compounds into the cell wall matrix in CCR-RNAi lines.

  13. Validation of Hindi version of oral health impact profile-14 for adults

    Directory of Open Access Journals (Sweden)

    Manu Batra

    2015-01-01

    Full Text Available Introduction: Oral health has an impact on overall general health. It is important to assess the influence of these oral disorders on quality of life. Aim: To validate a Hindi version of the oral health impact profile-14 (OHIP-14 and to assess the instrument's psychometric properties in the Indian population. Materials and Methods: A cross-sectional study was performed in Moradabad city with a sample of 186 participants. The same individuals underwent clinical examinations by a calibrated dentist for recording simplified oral hygiene index (OHI-S index. The OHIP was initially translated and cross-culturally adapted to Hindi following guidelines; then, subsequently validated for the psychometric characteristics of reliability and validity. The reliability of the OHIP-14 was assessed by the use of Cronbach's coefficient. Reproducibility was evaluated by measuring test-retest reliability (intraclass correlation coefficient. Results: The overall value of Cronbach's alpha (α coefficient of the OHIP-14 was estimated to be 0.8. The corrected item-total correlation coefficients values were above 0.2 that has been recommended for including an item in a scale. All Spearman's rank correlation coefficients were statistically significant, whereas the highest association was detected within the physical disability subscale (rs = 0.37, and the lowest within the social disability (rs = 0.08. It was seen that the OHIP-14 scores were higher for those individuals who had higher OHI-S scores and vice-versa. Conclusion: The translated Hindi version of OHIP-14 questionnaire is a reliable and valid instrument to measure the oral health-related quality of life in the Indian adult population.

  14. Evolution of anthocyanin profile from grape to wine

    Directory of Open Access Journals (Sweden)

    Margherita Squadrito

    2010-09-01

    Significance and impact of the study: Only in varieties in which the anthocyanin profile of grapes is characterized by low percentages of di-oxygenated side-ring forms is it possible to gain information about the varietal origin of a young wine by comparing the profiles of both grape and wine. However, great care is required.

  15. DNA-SIP identifies sulfate-reducing Clostridia as important toluene degraders in tar-oil-contaminated aquifer sediment

    Energy Technology Data Exchange (ETDEWEB)

    Winderl, C.; Penning, H.; von Netzer, F.; Meckenstock, R.U.; Lueders, T. [Helmholtz Zentrum Munchen, Neuherberg (Germany)

    2010-10-15

    Global groundwater resources are constantly challenged by a multitude of contaminants such as aromatic hydrocarbons. Especially in anaerobic habitats, a large diversity of unrecognized microbial populations may be responsible for their degradation. Still, our present understanding of the respective microbiota and their ecophysiology is almost exclusively based on a small number of cultured organisms, mostly within the Proteobacteria. Here, by DNA-based stable isotope probing (SIP), we directly identified the most active sulfate-reducing toluene degraders in a diverse sedimentary microbial community originating from a tar-oil-contaminated aquifer at a former coal gasification plant. On incubation of fresh sediments with {sup 13}C{sub 7}-toluene, the production of both sulfide and (CS{sub 2}){sup 13}CO{sub 2} was clearly coupled to the {sup 13}Clabeling of DNA of microbes related to Desulfosporosinus spp. within the Peptococcaceae (Clostridia). The screening of labeled DNA fractions also suggested a novel benzylsuccinate synthase alpha-subunit (bssA) sequence type previously only detected in the environment to be tentatively affiliated with these degraders. However, carbon flow from the contaminant into degrader DNA was only similar to 50%, pointing toward high ratios of heterotrophic CS{sub 2}-fixation during assimilation of acetyl-CoA originating from the contaminant by these degraders. These findings demonstrate that the importance of non-proteobacterial populations in anaerobic aromatics degradation, as well as their specific ecophysiology in the subsurface may still be largely ungrasped.

  16. Impact of response shift on the assessment of treatment effects using the Oral Health Impact Profile.

    Science.gov (United States)

    Reissmann, Daniel R; Remmler, Antje; John, Mike T; Schierz, Oliver; Hirsch, Christian

    2012-12-01

    The assessment of changes in oral health-related quality of life (OHRQoL) is challenging because individuals' concepts and internal standards of OHRQoL may change over time. The aim of this study was to detect response shifts in OHRQoL assessments made using the Oral Health Impact Profile (OHIP). Oral health-related quality of life was assessed in a consecutive sample of 126 patients seeking prosthodontic care. Patients were asked to rate their OHRQoL before treatment started and 1 month after treatment was finished, using the German 49-item version of the OHIP. When rating their OHRQoL after treatment, patients were also asked to rate their pre-treatment OHRQoL without having access to their baseline data. The response shift was calculated as the difference in OHIP summary scores between the initial assessment and the retrospective baseline assessment. The OHIP mean scores decreased from 31.8 at the initial baseline assessment to 24.4 after treatment. The retrospective baseline assessment resulted in an OHIP mean score of 38.1, corresponding to a response shift of 6.3 OHIP points. The effect size (Cohen's d = 0.21) of the response shift was considered small. The response shift phenomenon and its magnitude have important implications for dental practice, where patients and dentists often assess perceived treatment effects retrospectively. © 2012 Eur J Oral Sci.

  17. Response of temperature and density profiles to heat deposition profile and its impact on global scaling in LHD

    International Nuclear Information System (INIS)

    Yamada, H.; Murakami, S.; Yamazaki, K.

    2002-01-01

    Energy confinement and heat transport of net current-free NBI-heated plasmas in the Large Helical Device (LHD) are discussed with an emphasis on density dependence. Although the apparent density dependence of the energy confinement time has been demonstrated in a wide parameter range in LHD, the loss of this dependence has been observed in the high density regime under the specific condition. Broad heat deposition due to off-axis alignment and shallow penetration of neutral beams degrades the global energy confinement while the local heat transport maintains a clear temperature dependence lying between Bohm and gyro-Bohm characteristics. The central heat deposition inclines towards an intrinsic density dependence like τ E ∝(n-bar e /P) 0.6 from the saturated state. The broadening of the temperature profile due to the broad heat deposition profile contrasts with the invariant property which has observed widely as profile consistency and stiffness in tokamak experiments. (author)

  18. Response of temperature and density profiles to heat deposition profile and its impact on global scaling in LHD

    International Nuclear Information System (INIS)

    Yamada, H.; Murakami, S.; Yamazaki, K.

    2003-01-01

    Energy confinement and heat transport of net current-free NBI-heated plasmas in the Large Helical Device (LHD) are discussed with an emphasis on density dependence. Although the apparent density dependence of the energy confinement time has been demonstrated in a wide parameter range in LHD, the loss of this dependence has been observed in the high density regime under the specific condition. Broad heat deposition due to off-axis alignment and shallow penetration of neutral beams degrades the global energy confinement while the local heat transport maintains a clear temperature dependence lying between Bohm and gyro-Bohm characteristics. The central heat deposition inclines towards an intrinsic density dependence like τ E ∝(n-bars e /P) 0.6 from the saturated state. The broadening of the temperature profile due to the broad heat deposition profile contrasts with the invariant property which has observed widely as profile consistency and stiffness in tokamak experiments. (author)

  19. Social impact assessment and management methodology using social indicators and planning strategies

    International Nuclear Information System (INIS)

    Olsen, M.E.; Curry, M.G.; Greene, M.R.; Melber, B.D.; Merwin, D.J.

    1978-08-01

    The scope of environmental impact statements prepared during the past few years has steadily expanded to incorporate all aspects of the social as well as the natural environment, including demographic, economic, social, political, and cultural conditions. Broadly conceived, social impacts are alterations in people's living conditions that occur in conjunction with a new policy, program, or project, and that (1) are in addition to all other concurrent changes produced by other factors, and (2) are seen by those affected as significant social events. Since any social environment is constantly changing, the crucial problems in analyzing social impacts are to identify those social alterations that are a direct or indirect result of the specific action under examination, apart from all other events and changes, and to determine which of these alterations are having significant social effects on the people involved. Three features of this conception of social impacts are especially noteworthy. First, although impacts are often thought of as undesirable or detrimental in nature, they may also be desirable or beneficial. Second, although impacts are often described as caused by prior intervening innovations, in reality they always interact with their original causes in a reciprocal process, either immediately or after some time lag. Third, the purpose of social impact assessment is to enable policy makers to anticipate and plan for potential impacts before they occur, and then act to prevent or mitigate undesired impacts. A new methodology for performing social impact assessment and management studies that meet current needs by emphasizing standardized social indicators and social planning techniques is proposed. We refer to our approach as the Social Impact and Planning (SIP) method of social impact assessment

  20. Adjuvant tamoxifen influences the lipid profile in breast cancer patients.

    Science.gov (United States)

    Lin, Che; Chen, Li-Sheng; Kuo, Shou-Jen; Chen, Dar-Ren

    2014-02-01

    Currently there is a debate regarding whether tamoxifen used in breast cancer has an impact on lipid profiles. The aim of this study was to determine whether tamoxifen has an impact on the serum lipid profile in Taiwanese women. Data of 109 patients were collected from the routine clinical follow-up for women with hormone receptor-positive breast cancer who were treated between July 2005 and March 2008. These patients were divided into 2 subgroups, based on their tumor grade and lymph node status. Subgroup 1 patients had tumor grade I/II and a negative lymph node status. Those patients with tumor grade III or a positive lymph node status were defined as subgroup 2. In the 109 patients, the mean serum total cholesterol (TC) levels after tamoxifen treatment, as well as the serum low-density lipoprotein cholesterol (LDL-C) levels, were lower than the baseline levels, with statistically significant differences. Treatment with tamoxifen lowered the serum TC and LDL-C levels in both subgroups. The results indicate that tamoxifen has an impact on the serum lipid profile of breast cancer patients in Taiwan. Physicians should follow up the lipid profile in these patients.

  1. Impact of INTERMACS Profile on Clinical Outcomes for Patients Supported With the Total Artificial Heart.

    Science.gov (United States)

    Shah, Keyur B; Thanavaro, Kristin L; Tang, Daniel G; Quader, Mohammed A; Mankad, Anit K; Tchoukina, Inna; Thacker, Leroy R; Smallfield, Melissa C; Katlaps, Gundars; Hess, Michael L; Cooke, Richard H; Kasirajan, Vigneshwar

    2016-11-01

    Insufficient data delineate outcomes for Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) profile 1 patients with the total artificial heart (TAH). We studied 66 consecutive patients implanted with the TAH at our institution from 2006 through 2012 and compared outcome by INTERMACS profile. INTERMACS profiles were adjudicated retrospectively by a reviewer blinded to clinical outcomes. Survival after TAH implantation at 6 and 12 months was 76% and 71%, respectively. INTERMACS profile 1 patients had decreased 6-month survival on the device compared with those in profiles 2-4 (74% vs 95%, log rank: P = .015). For the 50 patients surviving to heart transplantation, the 1-year posttransplant survival was 82%. There was no difference in 1-year survival when comparing patients in the INTERMACS 1 profile with less severe profiles (79% vs 84%; log rank test P = .7; hazard ratio [confidence interval] 1.3 [0.3-4.8]). Patients implanted with the TAH as INTERMACS profile 1 had reduced survival to transplantation compared with less sick profiles. INTERMACS profile at the time of TAH implantation did not affect 1-year survival after heart transplantation. Copyright © 2016 Elsevier Inc. All rights reserved.

  2. Assessing Basal and Acute Autophagic Responses in the Adult Drosophila Nervous System: The Impact of Gender, Genetics and Diet on Endogenous Pathway Profiles.

    Directory of Open Access Journals (Sweden)

    Eric P Ratliff

    Full Text Available The autophagy pathway is critical for the long-term homeostasis of cells and adult organisms and is often activated during periods of stress. Reduced pathway efficacy plays a central role in several progressive neurological disorders that are associated with the accumulation of cytotoxic peptides and protein aggregates. Previous studies have shown that genetic and transgenic alterations to the autophagy pathway impacts longevity and neural aggregate profiles of adult Drosophila. In this study, we have identified methods to measure the acute in vivo induction of the autophagy pathway in the adult fly CNS. Our findings indicate that the genotype, age, and gender of adult flies can influence pathway responses. Further, we demonstrate that middle-aged male flies exposed to intermittent fasting (IF had improved neuronal autophagic profiles. IF-treated flies also had lower neural aggregate profiles, maintained more youthful behaviors and longer lifespans, when compared to ad libitum controls. In summary, we present methodology to detect dynamic in vivo changes that occur to the autophagic profiles in the adult Drosophila CNS and that a novel IF-treatment protocol improves pathway response in the aging nervous system.

  3. Clinical profile and impact on quality of life: Seven years experience with patients of alopecia areata

    Directory of Open Access Journals (Sweden)

    Nawaf Al-Mutairi

    2011-01-01

    Full Text Available Background: Alopecia areata (AA is the most common cause of localized, non-scarring alopecia. Stress and other psychological factors have been implicated in the causation of the disease, and it is also found to alter the course of the disease process. Unfortunately no one has studied the impact of AA on the quality of life, which includes the social life of the patients. Aim: To study the clinical profile and impact of alopecia areata on the quality of life, including the social life of adult patients with severe forms of the disease. Methods: The present study determined the clinical pattern of AA and its impact on the quality of life (QOL in all the patients with severe forms of alopecia areata attending the Dermatology Outpatient Department. Results: The male : female ratio was 1.86 : 1. Most (58.03% of the patients were between 21 and 40 years of age. Almost 40% of the patients had associated systemic disease or other dermatological disorders. A family history of AA was found in 593 (20.02% of the patients. Nail changes were observed in 297 (10% of the patients. There were significant differences between the mean Dermatology Life Quality Index (DLQI score in cases with severe forms of AA and controls ( p0 < 0.001. Conclusions: Severe forms of alopecia areata had a major impact on the psychosocial well-being of the patients. These individuals had to be treated early, and they required more than just prescription drugs. Educational and psychological support in addition to medical therapy for AA could improve their long-term physical outcomes.

  4. A benchmark of co-flow and cyclic deposition/etch approaches for the selective epitaxial growth of tensile-strained Si:P

    Science.gov (United States)

    Hartmann, J. M.; Veillerot, M.; Prévitali, B.

    2017-10-01

    We have compared co-flow and cyclic deposition/etch processes for the selective epitaxial growth of Si:P layers. High growth rates, relatively low resistivities and significant amounts of tensile strain (up to 10 nm min-1, 0.55 mOhm cm and a strain equivalent to 1.06% of substitutional C in Si:C layers) were obtained at 700 °C, 760 Torr with a co-flow approach and a SiH2Cl2 + PH3 + HCl chemistry. This approach was successfully used to thicken the sources and drains regions of n-type fin-shaped Field Effect Transistors. Meanwhile, the (Si2H6 + PH3/HCl + GeH4) CDE process evaluated yielded at 600 °C, 80 Torr even lower resistivities (0.4 mOhm cm, typically), at the cost however of the tensile strain which was lost due to (i) the incorporation of Ge atoms (1.5%, typically) into the lattice during the selective etch steps and (ii) a reduction by a factor of two of the P atomic concentration in CDE layers compared to that in layers grown in a single step (5 × 1020 cm-3 compared to 1021 cm-3).

  5. Impact of Te and ne on edge current density profiles in ELM mitigated regimes on ASDEX Upgrade

    Science.gov (United States)

    Dunne, M. G.; Rathgeber, S.; Burckhart, A.; Fischer, R.; Giannone, L.; McCarthy, P. J.; Schneider, P. A.; Wolfrum, E.; the ASDEX Upgrade Team

    2015-01-01

    ELM resolved edge current density profiles are reconstructed using the CLISTE equilibrium code. As input, highly spatially and temporally resolved edge electron temperature and density profiles are used in addition to data from the extensive set of external poloidal field measurements available at ASDEX Upgrade, flux loop difference measurements, and current measurements in the scrape-off layer. Both the local and flux surface averaged current density profiles are analysed for several ELM mitigation regimes. The focus throughout is on the impact of altered temperature and density profiles on the current density. In particular, many ELM mitigation regimes rely on operation at high density. Two reference plasmas with type-I ELMs are analysed, one with a deuterium gas puff and one without, in order to provide a reference for the behaviour in type-II ELMy regimes and high density ELM mitigation with external magnetic perturbations at ASDEX Upgrade. For type-II ELMs it is found that while a similar pedestal top pressure is sustained at the higher density, the temperature gradient decreases in the pedestal. This results in lower local and flux surface averaged current densities in these phases, which reduces the drive for the peeling mode. No significant differences between the current density measured in the type-I phase and ELM mitigated phase is seen when external perturbations are applied, though the pedestal top density was increased. Finally, ELMs during the nitrogen seeded phase of a high performance discharge are analysed and compared to ELMs in the reference phase. An increased pedestal pressure gradient, which is the source of confinement improvement in impurity seeded discharges, causes a local current density increase. However, the increased Zeff in the pedestal acts to reduce the flux surface averaged current density. This dichotomy, which is not observed in other mitigation regimes, could act to stabilize both the ballooning mode and the peeling mode at the

  6. Impacts of temperature and lunar day on gene expression profiles during a monthly reproductive cycle in the brooding coral Pocillopora damicornis.

    Science.gov (United States)

    Crowder, Camerron M; Meyer, Eli; Fan, Tung-Yung; Weis, Virginia M

    2017-08-01

    Reproductive timing in brooding corals has been correlated to temperature and lunar irradiance, but the mechanisms by which corals transduce these environmental variables into molecular signals are unknown. To gain insight into these processes, global gene expression profiles in the coral Pocillopora damicornis were examined (via RNA-Seq) across lunar phases and between temperature treatments, during a monthly planulation cycle. The interaction of temperature and lunar day together had the largest influence on gene expression. Mean timing of planulation, which occurred at lunar days 7.4 and 12.5 for 28- and 23°C-treated corals, respectively, was associated with an upregulation of transcripts in individual temperature treatments. Expression profiles of planulation-associated genes were compared between temperature treatments, revealing that elevated temperatures disrupted expression profiles associated with planulation. Gene functions inferred from homologous matches to online databases suggest complex neuropeptide signalling, with calcium as a central mediator, acting through tyrosine kinase and G protein-coupled receptor pathways. This work contributes to our understanding of coral reproductive physiology and the impacts of environmental variables on coral reproductive pathways. © 2017 John Wiley & Sons Ltd.

  7. Hemispheric aerosol vertical profiles: anthropogenic impacts on optical depth and cloud nuclei.

    Science.gov (United States)

    Clarke, Antony; Kapustin, Vladimir

    2010-09-17

    Understanding the effect of anthropogenic combustion upon aerosol optical depth (AOD), clouds, and their radiative forcing requires regionally representative aerosol profiles. In this work, we examine more than 1000 vertical profiles from 11 major airborne campaigns in the Pacific hemisphere and confirm that regional enhancements in aerosol light scattering, mass, and number are associated with carbon monoxide from combustion and can exceed values in unperturbed regions by more than one order of magnitude. Related regional increases in a proxy for cloud condensation nuclei (CCN) and AOD imply that direct and indirect aerosol radiative effects are coupled issues linked globally to aged combustion. These profiles constrain the influence of combustion on regional AOD and CCN suitable for challenging climate model performance and informing satellite retrievals.

  8. Psychosocial work factors, major depressive and generalised anxiety disorders: results from the French national SIP study.

    Science.gov (United States)

    Murcia, Marie; Chastang, Jean-François; Niedhammer, Isabelle

    2013-04-25

    Anxiety and depression are prevalent mental disorders in working populations. The risk factors of these disorders are not completely well known. Developing knowledge on occupational risk factors for mental disorders appears crucial. This study investigates the association between various classical and emergent psychosocial work factors and major depressive and generalised anxiety disorders in the French working population. The study was based on a national random sample of 3765 men and 3944 women of the French working population (SIP 2006 survey). Major Depressive Disorder (MDD) and Generalised Anxiety Disorder (GAD) were measured using a standardised diagnostic interview (MINI). Occupational factors included psychosocial work factors as well as biomechanical, physical, and chemical exposures. Adjustment variables included age, occupation, marital status, social support, and life events. Multivariate analysis was performed using logistic regression analysis. Low decision latitude, overcommitment, and emotional demands were found to be risk factors for both MDD-GAD among both genders. Other risk factors were observed: high psychological demands, low reward, ethical conflict, and job insecurity, but differences were found according to gender and outcome. Significant interaction terms were observed suggesting that low decision latitude, high psychological demands, and job insecurity had stronger effects on mental disorders for men than for women. Given the cross-sectional study design, no causal conclusion could be drawn. This study showed significant associations between classical and emergent psychosocial work factors and MDD-GAD. Preventive actions targeting various psychosocial work factors, including emergent factors, may help to reduce mental disorders at the workplace. Copyright © 2012 Elsevier B.V. All rights reserved.

  9. Subpixel Inundation Mapping Using Landsat-8 OLI and UAV Data for a Wetland Region on the Zoige Plateau, China

    Directory of Open Access Journals (Sweden)

    Haoming Xia

    2017-01-01

    Full Text Available Wetland inundation is crucial to the survival and prosperity of fauna and flora communities in wetland ecosystems. Even small changes in surface inundation may result in a substantial impact on the wetland ecosystem characteristics and function. This study presented a novel method for wetland inundation mapping at a subpixel scale in a typical wetland region on the Zoige Plateau, northeast Tibetan Plateau, China, by combining use of an unmanned aerial vehicle (UAV and Landsat-8 Operational Land Imager (OLI data. A reference subpixel inundation percentage (SIP map at a Landsat-8 OLI 30 m pixel scale was first generated using high resolution UAV data (0.16 m. The reference SIP map and Landsat-8 OLI imagery were then used to develop SIP estimation models using three different retrieval methods (Linear spectral unmixing (LSU, Artificial neural networks (ANN, and Regression tree (RT. Based on observations from 2014, the estimation results indicated that the estimation model developed with RT method could provide the best fitting results for the mapping wetland SIP (R2 = 0.933, RMSE = 8.73% compared to the other two methods. The proposed model with RT method was validated with observations from 2013, and the estimated SIP was highly correlated with the reference SIP, with an R2 of 0.986 and an RMSE of 9.84%. This study highlighted the value of high resolution UAV data and globally and freely available Landsat data in combination with the developed approach for monitoring finely gradual inundation change patterns in wetland ecosystems.

  10. Volatile organic compounds (VOCs) source profiles of on-road vehicle emissions in China.

    Science.gov (United States)

    Hong-Li, Wang; Sheng-Ao, Jing; Sheng-Rong, Lou; Qing-Yao, Hu; Li, Li; Shi-Kang, Tao; Cheng, Huang; Li-Ping, Qiao; Chang-Hong, Chen

    2017-12-31

    Volatile Organic Compounds (VOCs) source profiles of on-road vehicles were widely studied as their critical roles in VOCs source apportionment and abatement measures in megacities. Studies of VOCs source profiles from on-road motor vehicles from 2001 to 2016 were summarized in this study, with a focus on the comparisons among different studies and the potential impact of different factors. Generally, non-methane hydrocarbons dominated the source profile of on-road vehicle emissions. Carbonyls, potential important components of vehicle emission, were seldom considered in VOCs emissions of vehicles in the past and should be paid more attention to in further study. VOCs source profiles showed some variations among different studies, and 6 factors were extracted and studied due to their impact to VOCs source profile of on-road vehicles. Vehicle types, being dependent on engine types, and fuel types were two dominant factors impacting VOCs sources profiles of vehicles. In comparison, impacts of ignitions, driving conditions and accumulated mileage were mainly due to their influence on the combustion efficiency. An opening and interactive database of VOCs from vehicle emissions was critically essential in future, and mechanisms of sharing and inputting relative research results should be formed to encourage researchers join the database establishment. Correspondingly, detailed quality assurance and quality control procedures were also very important, which included the information of test vehicles and test methods as detailed as possible. Based on the community above, a better uncertainty analysis could be carried out for the VOCs emissions profiles, which was critically important to understand the VOCs emission characteristics of the vehicle emissions. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. Measurement of mesoscopic Si:P delta-doped devices fabricated by rapid STM hydrogen depassivation lithography via field-emission

    Science.gov (United States)

    Rudolph, M.; Carr, S. M.; Subramania, G.; Ten Eyck, G.; Dominguez, J.; Lilly, M. P.; Carroll, M. S.; Bussmann, E.

    2014-03-01

    Recently, a method to fabricate nanoelectronic and quantum devices has been developed that utilizes scanning tunneling microscopy (STM) to place dopants (P) into Si with deterministic atomic-precision. Dopant placement is achieved via STM hydrogen depassivation lithography (HDL). Typically HDL is performed in a low-voltage tunneling mode where electrons desorb one H at a time, which requires extremely slow scan rates. Here, we introduce a high-voltage field-emission HDL, increasing patterning scan rate by an order of magnitude. Using the field-emission mode, we fabricated several HDL-patterned Si:P delta-doped devices, including a microscale multi-terminal Hall Effect device and a nanoscale quantum point contact. Low temperature transport measurements of the Hall device reveal a dopant density of 1014 cm-2, resistance of 2 k Ω/square, and mobility of 30 cm2/Vs. The quantum point contact showed a blockaded voltage range of 80 mV, comparable to other similar devices patterned using conventional HDL. This work was performed, in part, at the Center for Integrated Nanotechnologies, a U.S. DOE, Office of Basic Energy Sciences user facility. The work was supported by the Sandia National Laboratories Directed Research and Development Program. Sandia National Laboratories is a multi-program laboratory operated by Sandia Corporation, a Lockheed-Martin Company, for the U. S. Department of Energy under Contract No. DE-AC04-94AL85000.

  12. Statistical regularities in the rank-citation profile of scientists.

    Science.gov (United States)

    Petersen, Alexander M; Stanley, H Eugene; Succi, Sauro

    2011-01-01

    Recent science of science research shows that scientific impact measures for journals and individual articles have quantifiable regularities across both time and discipline. However, little is known about the scientific impact distribution at the scale of an individual scientist. We analyze the aggregate production and impact using the rank-citation profile c(i)(r) of 200 distinguished professors and 100 assistant professors. For the entire range of paper rank r, we fit each c(i)(r) to a common distribution function. Since two scientists with equivalent Hirsch h-index can have significantly different c(i)(r) profiles, our results demonstrate the utility of the β(i) scaling parameter in conjunction with h(i) for quantifying individual publication impact. We show that the total number of citations C(i) tallied from a scientist's N(i) papers scales as [Formula: see text]. Such statistical regularities in the input-output patterns of scientists can be used as benchmarks for theoretical models of career progress.

  13. Effect of third molar surgery on oral health-related quality of life in the first postoperative week using Dutch version of oral health impact profile-14

    NARCIS (Netherlands)

    van Wijk, A.; Kieffer, J.M.; Lindeboom, J.H.

    2009-01-01

    Purpose: The present study investigated the effect of third molar surgery on oral health-related quality of life, related to pain and clinical variables, in the first postoperative week using the Dutch version of the 14-item Oral Health Impact Profile. Materials and Methods: A total of 50 patients,

  14. Health-related quality of life assessments in osteoarthritis during NSAID treatment.

    Science.gov (United States)

    de Bock, G H; Hermans, J; van Marwijk, H W; Kaptein, A A; Mulder, J D

    1996-08-01

    There is some evidence that nabumetone (1000 mg once daily) in comparison with piroxicam (20 mg once daily) in patients with OA in general practice is associated with a lower incidence and less severe occurrence of stomach pain but with more withdrawals due to lack of efficacy. The aim of this analysis was to investigate whether these differences are reflected in health-related quality of life assessments. Patients (n = 198) included in this study were selected in general practice according to a protocol. The patients were randomized and treated for a period of six weeks. Clinical assessments were performed by the general practitioner (CP) during treatment. The Sickness Impact Profile (SIP), the Activities of Daily Living (ADL), and a pain questionnaire were filled out by the patients before and after treatment. As measured with the SIP, the ADL and the pain questionnaire, there were no significant differences between nabumetone and piroxicam. The correlations between (changes in) patient assessments and (changes in) clinical assessments were low. The differences between the two drugs regarding withdrawals and adverse events were not reflected by patient health-related quality of life assessments. There was a low correlation between patient health-related quality of life assessment and clinical assessments. To get a complete picture of the efficacy and safety of a drug, patient health-related quality of life assessments should be a part of a clinical trial.

  15. Hypnosis or cognitive behavioral training for the reduction of pain and nausea during cancer treatment: a controlled clinical trial.

    Science.gov (United States)

    Syrjala, K L; Cummings, C; Donaldson, G W

    1992-02-01

    Few controlled clinical trials have tested the efficacy of psychological techniques for reducing cancer pain or post-chemotherapy nausea and emesis. In this study, 67 bone marrow transplant patients with hematological malignancies were randomly assigned to one of four groups prior to beginning transplantation conditioning: (1) hypnosis training (HYP); (2) cognitive behavioral coping skills training (CB); (3) therapist contact control (TC); or (4) treatment as usual (TAU; no treatment control). Patients completed measures of physical functioning (Sickness Impact Profile; SIP) and psychological functioning (Brief Symptom Inventory; BSI), which were used as covariates in the analyses. Biodemographic variables included gender, age and a risk variable based on diagnosis and number of remissions or relapses. Patients in the HYP, CB and TC groups met with a clinical psychologist for two pre-transplant training sessions and ten in-hospital "booster" sessions during the course of transplantation. Forty-five patients completed the study and provided all covariate data, and 80% of the time series outcome data. Analyses of the principal study variables indicated that hypnosis was effective in reducing reported oral pain for patients undergoing marrow transplantation. Risk, SIP, and BSI pre-transplant were found to be effective predictors of inpatient physical symptoms. Nausea, emesis and opioid use did not differ significantly between the treatment groups. The cognitive behavioral intervention, as applied in this study, was not effective in reducing the symptoms measured.

  16. The impact of in-canopy wind profile formulations on heat flux estimation in an open orchard using the remote sensing-based two-source model

    Directory of Open Access Journals (Sweden)

    C. Cammalleri

    2010-12-01

    Full Text Available For open orchard and vineyard canopies containing significant fractions of exposed soil (>50%, typical of Mediterranean agricultural regions, the energy balance of the vegetation elements is strongly influenced by heat exchange with the bare soil/substrate. For these agricultural systems a "two-source" approach, where radiation and turbulent exchange between the soil and canopy elements are explicitly modelled, appears to be the only suitable methodology for reliably assessing energy fluxes. In strongly clumped canopies, the effective wind speed profile inside and below the canopy layer can strongly influence the partitioning of energy fluxes between the soil and vegetation components. To assess the impact of in-canopy wind profile on model flux estimates, an analysis of three different formulations is presented, including algorithms from Goudriaan (1977, Massman (1987 and Lalic et al. (2003. The in-canopy wind profile formulations are applied to the thermal-based two-source energy balance (TSEB model developed by Norman et al. (1995 and modified by Kustas and Norman (1999. High resolution airborne remote sensing images, collected over an agricultural area located in the western part of Sicily (Italy comprised primarily of vineyards, olive and citrus orchards, are used to derive all the input parameters needed to apply the TSEB. The images were acquired from June to October 2008 and include a relatively wide range of meteorological and soil moisture conditions. A preliminary sensitivity analysis of the three wind profile algorithms highlights the dependence of wind speed just above the soil/substrate to leaf area index and canopy height over the typical range of canopy properties encountered in these agricultural areas. It is found that differences among the models in wind just above the soil surface are most significant under sparse and medium fractional cover conditions (15–50%. The TSEB model heat flux estimates are compared with micro

  17. Unearthing the ecology of soil microorganisms using a high resolution DNA-SIP approach to explore cellulose and xylose metabolism in soil

    Directory of Open Access Journals (Sweden)

    Charles ePepe-Ranney

    2016-05-01

    Full Text Available We explored microbial contributions to decomposition using a sophisticated approach to DNA Stable Isotope Probing (SIP. Our experiment evaluated the dynamics and ecological characteristics of functionally defined microbial groups that metabolize labile and structural C in soils. We added to soil a complex amendment representing plant derived organic matter substituted with either 13C-xylose or 13C-cellulose to represent labile and structural C pools derived from abundant components of plant biomass. We found evidence for 13C-incorporation into DNA from 13C-xylose and 13C-cellulose in 49 and 63 operational taxonomic units (OTUs, respectively. The types of microorganisms that assimilated 13C in the 13C-xylose treatment changed over time being predominantly Firmicutes at day 1 followed by Bacteroidetes at day 3 and then Actinobacteria at day 7. These 13C-labeling dynamics suggest labile C traveled through different trophic levels. In contrast, microorganisms generally metabolized cellulose-C after 14 days and did not change to the same extent in phylogenetic composition over time. Microorganisms that metabolized cellulose-C belonged to poorly characterized but cosmopolitan soil lineages including Verrucomicrobia, Chloroflexi and Planctomycetes.

  18. Effect of third molar surgery on oral health-related quality of life in the first postoperative week using Dutch version of Oral Health Impact Profile-14

    NARCIS (Netherlands)

    van Wijk, Arjen; Kieffer, Jacobien M.; Lindeboom, Jerome H.

    2009-01-01

    The present study investigated the effect of third molar surgery on oral health-related quality of life, related to pain and clinical variables, in the first postoperative week using the Dutch version of the 14-item Oral Health Impact Profile. A total of 50 patients, referred to the Department of

  19. Doping profile measurement on textured silicon surface

    Science.gov (United States)

    Essa, Zahi; Taleb, Nadjib; Sermage, Bernard; Broussillou, Cédric; Bazer-Bachi, Barbara; Quillec, Maurice

    2018-04-01

    In crystalline silicon solar cells, the front surface is textured in order to lower the reflection of the incident light and increase the efficiency of the cell. This texturing whose dimensions are a few micrometers wide and high, often makes it difficult to determine the doping profile measurement. We have measured by secondary ion mass spectrometry (SIMS) and electrochemical capacitance voltage profiling the doping profile of implanted phosphorus in alkaline textured and in polished monocrystalline silicon wafers. The paper shows that SIMS gives accurate results provided the primary ion impact angle is small enough. Moreover, the comparison between these two techniques gives an estimation of the concentration of electrically inactive phosphorus atoms.

  20. Impact of NO2 Profile Shape in OMI Tropospheric NO2 Retrievals

    Science.gov (United States)

    Lamsal, Lok; Krotkov, Nickolay A.; Pickering, K.; Schwartz, W. H.; Celarier, E. A.; Bucsela, E. J.; Gleason, J. F.; Philip, S.; Nowlan, C.; Martin, R. V.; hide

    2013-01-01

    Nitrogen oxides (NOx NO + NO2) are key actors in air quality and climate change. Tropospheric NO2 columns from the nadir-viewing satellite sensors have been widely used to understand sources and chemistry of NOx. We have implemented several improvements to the operational algorithm developed at NASA GSFC and retrieved tropospheric NO2 columns. We present tropospheric NO2 validation studies of the new OMI Standard Product version 2.1 using ground-based and in-situ aircraft measurements. We show how vertical profile of scattering weight and a-priori NO2 profile shapes, which are taken from chemistry-transport models, affect air mass factor (AMF) and therefore tropospheric NO2 retrievals. Users can take advantage of scattering weights information that is made available in the operational NO2 product. Improved tropospheric NO2 data retrieved using thoroughly evaluated high spatial resolution NO2 profiles are helpful to test models.

  1. DNA-, RNA-, and Protein-Based Stable-Isotope Probing for High-Throughput Biomarker Analysis of Active Microorganisms.

    Science.gov (United States)

    Jameson, Eleanor; Taubert, Martin; Coyotzi, Sara; Chen, Yin; Eyice, Özge; Schäfer, Hendrik; Murrell, J Colin; Neufeld, Josh D; Dumont, Marc G

    2017-01-01

    Stable-isotope probing (SIP) enables researchers to target active populations within complex microbial communities, which is achieved by providing growth substrates enriched in heavy isotopes, usually in the form of 13 C, 18 O, or 15 N. After growth on the substrate and subsequent extraction of microbial biomarkers, typically nucleic acids or proteins, the SIP technique is used for the recovery and analysis of isotope-labeled biomarkers from active microbial populations. In the years following the initial development of DNA- and RNA-based SIP, it was common practice to characterize labeled populations by targeted gene analysis. Such approaches usually involved fingerprint-based analyses or sequencing of clone libraries containing 16S rRNA genes or functional marker gene amplicons. Although molecular fingerprinting remains a valuable approach for rapid confirmation of isotope labeling, recent advances in sequencing technology mean that it is possible to obtain affordable and comprehensive amplicon profiles, metagenomes, or metatranscriptomes from SIP experiments. Not only can the abundance of microbial groups be inferred from metagenomes, but researchers can bin, assemble, and explore individual genomes to build hypotheses about the metabolic capabilities of labeled microorganisms. Analysis of labeled mRNA is a more recent advance that can provide independent metatranscriptome-based analysis of active microorganisms. The power of metatranscriptomics is that mRNA abundance often correlates closely with the corresponding activity of encoded enzymes, thus providing insight into microbial metabolism at the time of sampling. Together, these advances have improved the sensitivity of SIP methods and allow the use of labeled substrates at ecologically relevant concentrations. Particularly as methods improve and costs continue to drop, we expect that the integration of SIP with multiple omics-based methods will become prevalent components of microbial ecology studies

  2. 76 FR 43136 - Approval and Promulgation of Air Quality Implementation Plan; Kentucky; Disapproval of Interstate...

    Science.gov (United States)

    2011-07-20

    ... resistant to exploring a legislative approach to fixing some of the SIP issues, yet the correct process... economic impact on a substantial number of small entities. Small entities include small businesses, small... independently owned and operated and is not dominant in its field. After considering the economic impacts of...

  3. Prognostic impact of renal dysfunction does not differ according to the clinical profiles of patients: insight from the acute decompensated heart failure syndromes (ATTEND registry.

    Directory of Open Access Journals (Sweden)

    Taku Inohara

    Full Text Available BACKGROUND: Renal dysfunction associated with acute decompensated heart failure (ADHF is associated with impaired outcomes. Its mechanism is attributed to renal arterial hypoperfusion or venous congestion, but its prognostic impact based on each of these clinical profiles requires elucidation. METHODS AND RESULTS: ADHF syndromes registry subjects were evaluated (N = 4,321. Logistic regression modeling calculated adjusted odds ratios (OR for in-hospital mortality for patients with and without renal dysfunction. Renal dysfunction risk was calculated for subgroups with hypoperfusion-dominant (eg. cold extremities, a low mean blood pressure or a low proportional pulse pressure or congestion-dominant clinical profiles (eg. peripheral edema, jugular venous distension, or elevated brain natriuretic peptide to evaluate renal dysfunction's prognostic impact in the context of the two underlying mechanisms. On admission, 2,150 (49.8% patients aged 73.3 ± 13.6 years had renal dysfunction. Compared with patients without renal dysfunction, those with renal dysfunction were older and had dominant ischemic etiology jugular venous distension, more frequent cold extremities, and higher brain natriuretic peptide levels. Renal dysfunction was associated with in-hospital mortality (OR 2.36; 95% confidence interval 1.75-3.18, p0.05. CONCLUSIONS: Baseline renal dysfunction was significantly associated with in-hospital mortality in ADHF patients. The prognostic impact of renal dysfunction was the same, regardless of its underlying etiologic mechanism.

  4. Metabolic profile in different cathegories of diary cowst

    OpenAIRE

    Ulchar Igor; Celeska Irena; Ilievska Ksenija; Mitrov Dine; Dzhadzhovski Igor

    2008-01-01

    Knowing the values of the metabolic profile is important for prevention of so-called "production diseases" which have significant negative impact on the milk production. The aim of these investigations was determination of the metabolic profile and its referent values in the diary cows in several farms. Investigations included four categories of diary cows: pregnant heifers, cows in early lactation, cows in late lactation and dry cows. Discussion explains both significant differences of value...

  5. Radiological contrast media in the breastfeeding woman: a position paper of the Italian Society of Radiology (SIRM), the Italian Society of Paediatrics (SIP), the Italian Society of Neonatology (SIN) and the Task Force on Breastfeeding, Ministry of Health, Italy.

    Science.gov (United States)

    Cova, Maria Assunta; Stacul, Fulvio; Quaranta, Roberto; Guastalla, Pierpaolo; Salvatori, Guglielmo; Banderali, Giuseppe; Fonda, Claudio; David, Vincenzo; Gregori, Massimo; Zuppa, Antonio Alberto; Davanzo, Riccardo

    2014-08-01

    Breastfeeding is a well-recognised investment in the health of the mother-infant dyad. Nevertheless, many professionals still advise breastfeeding mothers to temporarily discontinue breastfeeding after contrast media imaging. Therefore, we performed this review to provide health professionals with basic knowledge and skills for appropriate use of contrast media. A joint working group of the Italian Society of Radiology (SIRM), Italian Society of Paediatrics (SIP), Italian Society of Neonatology (SIN) and Task Force on Breastfeeding, Ministry of Health, Italy prepared a review of the relevant medical literature on the safety profile of contrast media for the nursing infant/child. Breastfeeding is safe for the nursing infant of any post-conceptional age after administration of the majority of radiological contrast media to the mother; only gadolinium-based agents considered at high risk of nephrogenic systemic fibrosis (gadopentetate dimeglumine, gadodiamide, gadoversetamide) should be avoided in the breastfeeding woman as a precaution; there is no need to temporarily discontinue breastfeeding or to express and discard breast milk following the administration of contrast media assessed as compatible with breastfeeding. Breastfeeding women should receive unambiguous professional advice and clear encouragement to continue breastfeeding after imaging with the compatible contrast media. • Breastfeeding is a well-known investment in the health of the mother-infant dyad. • Breastfeeding is safe after administration of contrast media to the mother. • There is no need to temporarily discontinue breastfeeding following administration of contrast media.

  6. A design tool to study the impact of mission-profile on the reliability of SiC-based PV-inverter devices

    DEFF Research Database (Denmark)

    Sintamarean, Nicolae Cristian; Wang, Huai; Blaabjerg, Frede

    2014-01-01

    and is further used as an input to a lifetime model. The proposed reliability oriented design tool is used to study the impact of MP and device degradation (aging) in the PV-inverter lifetime. The obtained results indicate that the MP of the field where the PV-inverter is operating has an important impact......This paper introduces a reliability-oriented design tool for a new generation of grid connected PV-inverters. The proposed design tool consists of a real field mission profile model (for one year operation in USA-Arizona), a PV-panel model, a grid connected PV-inverter model, an electro......-thermal model and the lifetime model of the power semiconductor devices. A simulation model able to consider one year real field operation conditions (solar irradiance and ambient temperature) is developed. Thus, one year estimation of the converter devices thermal loading distribution is achieved...

  7. Relationship between patients' oral health-related quality of life, satisfaction with dentition, and personality profiles.

    Science.gov (United States)

    Karasneh, Jumana; Al-Omiri, Mahmoud K; Al-Hamad, Khaled Q; Al Quran, Firas A M

    2009-11-01

    The aim of this study was to investigate the relationship between patients' oral health-related quality of life, satisfaction with their dentition, and their personality profiles. Eighty-four patients (30 males and 54 females; mean age 31.9+/-12.7 years) seeking routine dental treatment were recruited for this study. A "Dental Impact on Daily Living" (DIDL) questionnaire was used to assess dental satisfaction and impact on daily living. An "Oral Health Impact Profile" (OHIP) was used to measure self-reported discomfort, disability, and dysfunction caused by oral conditions. Oral health-related quality of life was assessed using the "United Kingdom Oral Health Related Quality of Life" measure (OHQoL-U.K). A "NEO Five Factor inventory" (NEO-FFI) was used to assess personality profiles. The dentition has a measurable impact on daily living as well as with satisfaction with appearance, pain levels, oral comfort, general performance, and eating capability (p=0.000). Younger patients had more profound oral health impacts (p=0.045) and higher neuroticism scores (0.043). OHIP scores were significantly related to OHQoL-UK scores (p=0.000). DIDL scores had significant correlations with OHIP and OHQoL-UK scores (p<0.05). Significant correlations were established between neuroticism and satisfaction with oral comfort, extraversion and total satisfaction and satisfaction with general performance, and openness and satisfaction with appearance (p<0.05). OHIP and OHQoL-UK scores had no significant correlations with psychological profiles. The status of the oral cavity can have a definitive impact on patients' daily living and quality of life regardless age, gender, and level of education. Patients' satisfaction with their dentition has definitive impacts on daily living, quality of life, and dental perceptions. Personality profiles (neuroticism; extraversion, and openness) may influence dental perceptions, play a significant role in shaping satisfaction with dentition, and help

  8. Study on impact of habitat degradation on proximate composition and amino acid profile of Indian major carps from different habitats.

    Science.gov (United States)

    Hussain, Bilal; Sultana, Tayyaba; Sultana, Salma; Ahmed, Z; Mahboob, Shahid

    2018-05-01

    This investigation is aimed to study an impact of habitat degradation on proximate composition and amino acid (AAs) profile of Catla catla, Labeo rohita and Cirrhinus mrigala collected from polluted, non-polluted area (upstream) and a commercial fish farm. The amino acid profile was estimated by the amino acid analyzer. C. catla collected from the polluted environment had highest lipid, protein and ash contents (12.04 ± 0.01, 13.45 ± 0.01 and 0.93 ± 0.03%, respectively). The high protein content (14.73 ± 0.01 and 14.12 ± 0. 01%) was recorded in C. catla procured from non-polluted (upstream) wild habitat of River Chenab and controlled commercial fish farm. Farmed fish species showed comparatively higher moisture contents followed by upstream and polluted area fishes. C. mrigala showed significant differences in amino acid and proximate composition collected from a polluted site of the river Chenab. C. catla collected from non-polluted site of the river showed an excellent nutrient profile, followed by L. rohita (wild and farmed) and C. mrigala (polluted area), respectively. All fishes from the polluted areas of the River Chenab indicated a significant decrease in the concentration of some AAs when compared to farmed and wild (upstream) major carps. Omitting of some important AAs was also observed in the meat of fish harvested from polluted habitat of this river. C. mrigala and L. rohita exhibited a significant increase in the concentration of some of non-essential amino acids such as cysteine in their meat. The results indicated that wild fish (upstream) and farmed fish species had highest protein contents and amino acid profile and hence appeared to be the best for human consumption. The proximate composition and AAs profiles of fish harvested from the polluted area of the river clearly indicated that efforts shall be made for the restoration of habitat to continue the requirement of high quality fish meat at a low cost to the human

  9. Socioeconomic profile of Nye County, Nevada: Community services inventory

    International Nuclear Information System (INIS)

    1986-09-01

    The Nevada Nuclear Waste Storage Investigations Project is preparing socioeconomic profiles of Nye County, Nevada, and communities in Nye County that could be affected by siting, construction, operation, and decommissioning of a high-level nuclear waste repository at Yucca Mountain, located in Nye County. These profiles serve as a data base for evaluating local community service impacts; store existing socioeconomic data in a uniform, readily accessible format; identify the need for additional data; and assist in developing a plan for monitoring and mitigating any significant adverse impacts that may be associated with site characterization and potential repository development. This element of the socioeconomic profiles contains an inventory of community services provided by local, county, and state agencies and volunteer organizations to residents of Amargosa Valley, Beatty, and Pahrump. Services inventoried for each community include housing, growth management, general government, education, police protection, transportation networks, public clinics, private health personnel, parks and recreation, social services, libraries, ambulances, electric power, heating fuel, water, sewers and wastewater treatment, solid waste, and fire protection. The report includes a summary overview of service providers in Nye County, discussions of services provided to residents of the three communities, and summary tables. Data presented in this profile were collected through early 1985. Data collection efforts are ongoing and this profile will be updated periodically

  10. Impact of pyrrolidine-bispyrrole DNA minor groove binding agents and chirality on global proteomic profile in Escherichia Coli.

    Science.gov (United States)

    Yang, Ya-Ting; Lin, Chun-Yu; Jeng, Jingyueh; Ong, Chi-Wi

    2013-05-23

    There is great interest in the design of small molecules that selectively target minor grooves of duplex DNA for controlling specific gene expression implicated in a disease. The design of chiral small molecules for rational drug design has attracted increasing attention due to the chirality of DNA. Yet, there is limited research on the chirality effect of minor groove binders on DNA interaction, especially at the protein expression level. This paper is an attempt to illustrate that DNA binding affinity might not provide a full picture on the biological activities. Drug interacting at the genomic level can be translated to the proteomic level. Here we have illustrated that although the chiral bispyrrole-pyrrolidine-oligoamides, PySSPy and PyRSPy, showed low binding affinity to DNA, their influence at the proteomic level is significant. More importantly, the chirality also plays a role. Two-dimensional proteomic profile to identify the differentially expressed protein in Escherichia coli DH5α (E coli DH5α) were investigated. E coli DH5α incubated with the chiral PySSPy and PyRSPy, diastereomeric at the pyrrolidine ring, showed differential expression of eighteen proteins as observed through two dimensional proteomic profiling. These eighteen proteins identified by MALDI_TOF/TOF MS include antioxidant defense, DNA protection, protein synthesis, chaperone, and stress response proteins. No statistically significant toxicity was observed at the tested drug concentrations as measured via MTT assay. The current results showed that the chiral PySSPy and PyRSPy impact on the proteomic profiling of E coli DH5α, implicating the importance of drug chirality on biological activities at the molecular level.

  11. Confounding factors and genetic polymorphism in the evaluation of individual steroid profiling

    Science.gov (United States)

    Kuuranne, Tiia; Saugy, Martial; Baume, Norbert

    2014-01-01

    In the fight against doping, steroid profiling is a powerful tool to detect drug misuse with endogenous anabolic androgenic steroids. To establish sensitive and reliable models, the factors influencing profiling should be recognised. We performed an extensive literature review of the multiple factors that could influence the quantitative levels and ratios of endogenous steroids in urine matrix. For a comprehensive and scientific evaluation of the urinary steroid profile, it is necessary to define the target analytes as well as testosterone metabolism. The two main confounding factors, that is, endogenous and exogenous factors, are detailed to show the complex process of quantifying the steroid profile within WADA-accredited laboratories. Technical aspects are also discussed as they could have a significant impact on the steroid profile, and thus the steroid module of the athlete biological passport (ABP). The different factors impacting the major components of the steroid profile must be understood to ensure scientifically sound interpretation through the Bayesian model of the ABP. Not only should the statistical data be considered but also the experts in the field must be consulted for successful implementation of the steroidal module. PMID:24764553

  12. Liver Gene Expression Profiles of Rats Treated with Clofibric Acid

    Science.gov (United States)

    Michel, Cécile; Desdouets, Chantal; Sacre-Salem, Béatrice; Gautier, Jean-Charles; Roberts, Ruth; Boitier, Eric

    2003-01-01

    Clofibric acid (CLO) is a peroxisome proliferator (PP) that acts through the peroxisome proliferator activated receptor α, leading to hepatocarcinogenesis in rodents. CLO-induced hepatocarcinogenesis is a multi-step process, first transforming normal liver cells into foci. The combination of laser capture microdissection (LCM) and genomics has the potential to provide expression profiles from such small cell clusters, giving an opportunity to understand the process of cancer development in response to PPs. To our knowledge, this is the first evaluation of the impact of the successive steps of LCM procedure on gene expression profiling by comparing profiles from LCM samples to those obtained with non-microdissected liver samples collected after a 1 month CLO treatment in the rat. We showed that hematoxylin and eosin (H&E) staining and laser microdissection itself do not impact on RNA quality. However, the overall process of the LCM procedure affects the RNA quality, resulting in a bias in the gene profiles. Nonetheless, this bias did not prevent accurate determination of a CLO-specific molecular signature. Thus, gene-profiling analysis of microdissected foci, identified by H&E staining may provide insight into the mechanisms underlying non-genotoxic hepatocarcinogenesis in the rat by allowing identification of specific genes that are regulated by CLO in early pre-neoplastic foci. PMID:14633594

  13. 76 FR 43128 - Approval and Promulgation of Air Quality Implementation Plan; Alabama; Disapproval of Interstate...

    Science.gov (United States)

    2011-07-20

    ... fixing some of the SIP issues, yet the correct process under the existing Clean Air Act to appropriately... the rule will not have a significant economic impact on a substantial number of small entities. Small... its field. After considering the economic impacts of today's final rule on small entities, I certify...

  14. Impacts of daily intakes on the isomeric profiles of perfluoroalkyl substances (PFASs) in human serum.

    Science.gov (United States)

    Shan, Guoqiang; Wang, Zhi; Zhou, Lianqiu; Du, Pin; Luo, Xiaoxiao; Wu, Qiannian; Zhu, Lingyan

    2016-01-01

    Perfluoroalkyl substances (PFASs) have been well studied in human daily intake for assessment of potential health risks. However, little is known about the isomeric compositions of PFASs in daily intake and their impacts on isomeric profiles in humans. In this study, we investigated the occurrence of PFASs with isomeric analysis in various human exposure matrices including foodstuffs, tap water and indoor dust. Perfluorooctanesulfonate (PFOS) and/or perfluorooctanoate (PFOA) were predominant in these exposure matrices collected in Tianjin, China. In fish and meat, linear (n-) PFOA was enriched with a percentage of 92.2% and 99.6%, respectively. Although n-PFOS was higher in fish (84.8%) than in technical PFOS (ca. 70%), it was much lower in meat (63.1%) and vegetables (58.5%). Dietary intake contributed >99% of the estimated daily intake (EDI) for the general population. The isomeric profiles of PFOA and PFOS in human serum were predicted based on the EDI and a one-compartment, first-order pharmacokinetic model. The isomeric percentage of n-PFOA in the EDI (98.6%) was similar to that in human serum (predicted: 98.2%, previously measured: 99.7%) of Tianjin residents. The results suggest direct PFOA intake plays an important role in its isomeric compositions in humans. For PFOS, the predicted n-PFOS (69.3%) was much higher than the previously measured values (59.2%) in human serum. This implies that other factors, such as indirect exposure to PFOS precursors and multiple excretion pathways, may contribute to the lower percentage of n-PFOS in humans than of technical PFOS. Copyright © 2016 Elsevier Ltd. All rights reserved.

  15. The first decade of MALDI protein profiling

    DEFF Research Database (Denmark)

    Albrethsen, Jakob

    2011-01-01

    MALDI protein profiling has identified several important challenges in omics-based biomarker research. First, research into the analytical performance of a novel omics-platform of potential diagnostic impact must be carried out in a critical manner and according to common guidelines. Evaluation s...

  16. Micro-drinking behaviours and consumption of wine in different wine glass sizes: a laboratory study.

    Science.gov (United States)

    Zupan, Z; Pechey, R; Couturier, D L; Hollands, G J; Marteau, T M

    2017-06-12

    Tableware size may influence how much food and non-alcoholic drink is consumed. Preliminary evidence of the impact of glass size on purchasing of alcoholic drinks shows an increase in wine sales of almost 10% when the same portion of wine is served in a larger glass. The primary aim of the current study is to test if micro-drinking behaviours act as a mechanism that could underlie this effect, through an increase in drinking rate, sip duration and/or number of sips from a larger glass. In a between-subjects experimental design, 166 young women were randomised to drink a 175 ml portion of wine from either a smaller (250 ml) or larger (370 ml) wine glass. Primary outcomes were three micro-drinking behaviours, assessed observationally using video recordings: drinking rate, sip number and sip duration. Other possible mechanisms examined were satisfaction with the perceived amount of wine served and pleasure of the drinking experience, assessed using self-report measures. Wine drunk from the larger, compared with the smaller glass, was consumed more slowly and with shorter sip duration, counter to the hypothesised direction of effect. No differences were observed in any of the other outcome measures. These findings provide no support for the hypothesised mechanisms by which serving wine in larger wine glasses increases consumption. While micro-drinking behaviours may still prove to be a mechanism explaining consumption from different glass sizes, cross-validation of these results in a more naturalistic setting is needed.

  17. The impact of time perspective latent profiles on college drinking: a multidimensional approach.

    Science.gov (United States)

    Braitman, Abby L; Henson, James M

    2015-04-01

    Zimbardo and Boyd's(1) time perspective, or the temporal framework individuals use to process information, has been shown to predict health behaviors such as alcohol use. Previous studies supported the predictive validity of individual dimensions of time perspective, with some dimensions acting as protective factors and others as risk factors. However, some studies produced findings contrary to the general body of literature. In addition, time perspective is a multidimensional construct, and the combination of perspectives may be more predictive than individual dimensions in isolation; consequently, multidimensional profiles are a more accurate measure of individual differences and more appropriate for predicting health behaviors. The current study identified naturally occurring profiles of time perspective and examined their association with risky alcohol use. Data were collected from a college student sample (n = 431, mean age = 20.41 years) using an online survey. Time perspective profiles were identified using latent profile analysis. Bootstrapped regression models identified a protective class that engaged in significantly less overall drinking (β = -0.254) as well as engaging in significantly less episodic high risk drinking (β = -0.274). There was also emerging evidence of a high risk time perspective profile that was linked to more overall drinking (β = 0.198) and engaging in more high risk drinking (β = 0.245), though these differences were not significant. CONCLUSIONS/IMPORTANCE: These findings support examining time perspective in a multidimensional framework rather than individual dimensions in isolation. Implications include identifying students most in need of interventions, and tailoring interventions to target temporal framing in decision-making.

  18. Constructing Data Curation Profiles

    Directory of Open Access Journals (Sweden)

    Michael Witt

    2009-12-01

    Full Text Available This paper presents a brief literature review and then introduces the methods, design, and construction of the Data Curation Profile, an instrument that can be used to provide detailed information on particular data forms that might be curated by an academic library. These data forms are presented in the context of the related sub-disciplinary research area, and they provide the flow of the research process from which these data are generated. The profiles also represent the needs for data curation from the perspective of the data producers, using their own language. As such, they support the exploration of data curation across different research domains in real and practical terms. With the sponsorship of the Institute of Museum and Library Services, investigators from Purdue University and the University of Illinois interviewed 19 faculty subjects to identify needs for discovery, access, preservation, and reuse of their research data. For each subject, a profile was constructed that includes information about his or her general research, data forms and stages, value of data, data ingest, intellectual property, organization and description of data, tools, interoperability, impact and prestige, data management, and preservation. Each profile also presents a specific dataset supplied by the subject to serve as a concrete example. The Data Curation Profiles are being published to a public wiki for questions and discussion, and a blank template will be disseminated with guidelines for others to create and share their own profiles. This study was conducted primarily from the viewpoint of librarians interacting with faculty researchers; however, it is expected that these findings will complement a wide variety of data curation research and practice outside of librarianship and the university environment.

  19. Single-cell gene-expression profiling and its potential diagnostic applications

    Czech Academy of Sciences Publication Activity Database

    Stahlberg, A.; Kubista, Mikael; Aman, P.

    2011-01-01

    Roč. 11, č. 7 (2011), s. 735-740 ISSN 1473-7159 R&D Projects: GA ČR(CZ) GAP303/10/1338; GA ČR(CZ) GA301/09/1752 Institutional research plan: CEZ:AV0Z50520701 Keywords : gene-expression profiling * RT-qPCR * single-cell gene-expression profiling Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 4.859, year: 2011

  20. 76 FR 43167 - Approval and Promulgation of Air Quality Implementation Plan; North Carolina; Disapproval of...

    Science.gov (United States)

    2011-07-20

    ... to fixing some of the SIP issues, yet the correct process under the existing Clean Air Act to... will not have a significant economic impact on a substantial number of small entities. Small entities... economic impacts of today's final rule on small entities, I certify that this action will not have a...

  1. Abdominal obesity has the highest impact on metabolic profile in an overweight African population

    DEFF Research Database (Denmark)

    Handlos, L. N.; Witte, D. R.; Mwaniki, D. L.

    2012-01-01

    Aim: The aim of this study was to determine the association between different anthropometric parameters and metabolic profile in an overweight, adult, black Kenyan population. Methods: An opportunity sample of 245 overweight adult Kenyans (body mass index (BMI) ≥ 25 kg/m2) was analysed. A score...... anthropometric variables tested, WC and VAT thickness had the strongest negative association with the metabolic profile (β = 0.17 (0.09; 0.24) and 0.15 (0.08; 0.23), respectively). Conclusions: WC and VAT thickness were the strongest anthropometric predictors for the metabolic profile in overweight adult Kenyans...

  2. Psychometric evaluation of the Social Interaction Phobia Scale.

    Science.gov (United States)

    Reilly, Alison R; Carleton, R Nicholas; Weeks, Justin W

    2012-01-01

    The present study evaluated the psychometric properties of a novel measure of social anxiety symptoms, the Social Interaction Phobia Scale (SIPS), as a stand-alone item set, using an undergraduate sample (N=512). The 14-item SIPS has three subscales assessing Social Interaction Anxiety, Fear of Overt Evaluation, and Fear of Attracting Attention. Confirmatory factor analyses replicated the three-factor structure for the SIPS originally reported by Carleton et al. All SIPS scores demonstrated good internal consistency. The convergent validity of the SIPS was supported by strong and positive correlations between all SIPS scores and measures of social anxiety and fear of evaluation; the finding that the relationships between all SIPS scores and a social anxiety measure were stronger than relationships between all SIPS scores and measures of other constructs supported the discriminant validity of the SIPS. Results suggest that the SIPS possesses excellent psychometric properties.

  3. Impact of Physical Activity on Obesity and Lipid Profile of Adults with Intellectual Disability

    Science.gov (United States)

    Gawlik, Krystyna; Zwierzchowska, Anna; Celebanska, Diana

    2018-01-01

    Introduction: This study assessed overweight, obesity and lipid profiles in adults with intellectual disability and compared these metrics with their physical activity. Materials and Method: Basic somatic parameters, lipid profile and weekly physical activity were examined in 27 adults with moderate intellectual disability. Chi-square independence…

  4. Predicting the impact of vegetations in open channels with different distributaries' operations on water surface profile using artificial neural networks

    International Nuclear Information System (INIS)

    Abdeen, Mostafa A. M.

    2008-01-01

    Most of the open water irrigation channels in Egypt suffer from the infestation of aquatic weeds, especially the submerged ones that cause numerous hydraulic problems for the open channels themselves and their water distributaries such as increasing water losses, obstructing water flow, and reducing channels' water distribution efficiencies. Accurate simulation and prediction of flow behavior in such channels is very essential for water distribution decision makers. Artificial neural networks (ANN) have proven to be very successful in the simulation of several physical phenomena, in general, and in the water research field in particular. Therefore, the current study aims towards introducing the utilization of ANN in simulating the impact of vegetation in main open channel, which supplies water to different distributaries, on the water surface profile in this main channel. Specifically, the study, presented in the current paper utilizes ANN technique for the development of various models to simulate the impact of different submerged weeds' densities, different flow discharges, and different distributaries operation scheduling on the water surface profile in an experimental main open channel that supplies water to different distributaries. In the investigated experiment, the submerged weeds were simulated as branched flexible elements. The investigated experiment was considered as an example for implementing the same methodology and technique in a real open channel system. The results showed that the ANN technique is very successful in simulating the flow behavior of the pre-mentioned open channel experiment with the existence of the submerged weeds. In addition, the developed ANN models were capable of predicting the open channel flow behavior in all the submerged weeds' cases that were considered in the ANN development process

  5. Intelligent Advanced Communications IP Telephony Feasibility for the U.S. Navy. Volume 1

    Science.gov (United States)

    2007-10-01

    endpoint server, H.323<->SIP Proxy, SIP session border controller, SIP router, SIP registration server, Jingle server, ISDN passive and active...34 Support for SIP, AIX2, H.323 and Jingle protocols " Support for traditional digital telephony circuits, including hardware support for personal

  6. Approaches for diversity analysis of cultivable and non-cultivable bacteria in real soil

    Czech Academy of Sciences Publication Activity Database

    Štursa, P.; Uhlík, Ondřej; Kurzawová, V.; Koubek, J.; Ionescu, M.; Strohalm, M.; Lovecka, P.; Macek, Tomáš; Macková, M.

    2009-01-01

    Roč. 55, č. 9 (2009), s. 389-396 ISSN 1214-1178 Institutional research plan: CEZ:AV0Z40550506 Keywords : PCB * contaminated soil * rhizoremediation * SIP Subject RIV: EI - Biotechnology ; Bionics Impact factor: 0.697, year: 2009

  7. The impact of hydraulic flow unit & reservoir quality index on pressure profile and productivity index in multi-segments reservoirs

    Directory of Open Access Journals (Sweden)

    Salam Al-Rbeawi

    2017-12-01

    Full Text Available The objective of this paper is studying the impact of the hydraulic flow unit and reservoir quality index (RQI on pressure profile and productivity index of horizontal wells acting in finite reservoirs. Several mathematical models have been developed to investigate this impact. These models have been built based on the pressure distribution in porous media, depleted by a horizontal well, consist of multi hydraulic flow units and different reservoir quality index. The porous media are assumed to be finite rectangular reservoirs having different configurations and the wellbores may have different lengths. Several analytical models describing flow regimes have been derived wherein hydraulic flow units and reservoir quality index have been included in addition to rock and fluid properties. The impact of these two parameters on reservoir performance has also been studied using steady state productivity index.It has been found that both pressure responses and flow regimes are highly affected by the existence of multiple hydraulic flow units in the porous media and the change in reservoir quality index for these units. Positive change in the RQI could lead to positive change in both pressure drop required for reservoir fluids to move towards the wellbore and hence the productivity index.

  8. Study on impact of habitat degradation on proximate composition and amino acid profile of Indian major carps from different habitats

    Directory of Open Access Journals (Sweden)

    Bilal Hussain

    2018-05-01

    Full Text Available This investigation is aimed to study an impact of habitat degradation on proximate composition and amino acid (AAs profile of Catla catla, Labeo rohita and Cirrhinus mrigala collected from polluted, non-polluted area (upstream and a commercial fish farm. The amino acid profile was estimated by the amino acid analyzer. C. catla collected from the polluted environment had highest lipid, protein and ash contents (12.04 ± 0.01, 13.45 ± 0.01 and 0.93 ± 0.03%, respectively. The high protein content (14.73 ± 0.01 and 14.12 ± 0. 01% was recorded in C. catla procured from non-polluted (upstream wild habitat of River Chenab and controlled commercial fish farm. Farmed fish species showed comparatively higher moisture contents followed by upstream and polluted area fishes. C. mrigala showed significant differences in amino acid and proximate composition collected from a polluted site of the river Chenab. C. catla collected from non-polluted site of the river showed an excellent nutrient profile, followed by L. rohita (wild and farmed and C. mrigala (polluted area, respectively. All fishes from the polluted areas of the River Chenab indicated a significant decrease in the concentration of some AAs when compared to farmed and wild (upstream major carps. Omitting of some important AAs was also observed in the meat of fish harvested from polluted habitat of this river. C. mrigala and L. rohita exhibited a significant increase in the concentration of some of non-essential amino acids such as cysteine in their meat. The results indicated that wild fish (upstream and farmed fish species had highest protein contents and amino acid profile and hence appeared to be the best for human consumption. The proximate composition and AAs profiles of fish harvested from the polluted area of the river clearly indicated that efforts shall be made for the restoration of habitat to continue the requirement of high quality fish meat at a low cost to the

  9. Type I signal peptidases of Bacillus subtilis

    NARCIS (Netherlands)

    Tjalsma, Harold; Bolhuis, Albert; Bron, Sierd; Jongbloed, Jan; Meijer, Wilfried J.J.; Noback, Michiel; van Roosmalen, Maarten; Venema, Gerhardus; van Dijl, Jan Maarten; Hopsu Havu, VK; Jarvinen, M; Kirschke, H

    1997-01-01

    Bacillus subtilis contains at least three chromosomally-encoded type I signal peptidases (SPases; SipS, SipT, and SipU), which remove signal peptides from secretory proteins. In addition, certain B. subtilis (natto) strains contain plasmid-encoded type I SPases (SipP). The known type I SPases from

  10. Development of a multilocus-based approach for sponge (phylum Porifera) identification: refinement and limitations.

    Science.gov (United States)

    Yang, Qi; Franco, Christopher M M; Sorokin, Shirley J; Zhang, Wei

    2017-02-02

    For sponges (phylum Porifera), there is no reliable molecular protocol available for species identification. To address this gap, we developed a multilocus-based Sponge Identification Protocol (SIP) validated by a sample of 37 sponge species belonging to 10 orders from South Australia. The universal barcode COI mtDNA, 28S rRNA gene (D3-D5), and the nuclear ITS1-5.8S-ITS2 region were evaluated for their suitability and capacity for sponge identification. The highest Bit Score was applied to infer the identity. The reliability of SIP was validated by phylogenetic analysis. The 28S rRNA gene and COI mtDNA performed better than the ITS region in classifying sponges at various taxonomic levels. A major limitation is that the databases are not well populated and possess low diversity, making it difficult to conduct the molecular identification protocol. The identification is also impacted by the accuracy of the morphological classification of the sponges whose sequences have been submitted to the database. Re-examination of the morphological identification further demonstrated and improved the reliability of sponge identification by SIP. Integrated with morphological identification, the multilocus-based SIP offers an improved protocol for more reliable and effective sponge identification, by coupling the accuracy of different DNA markers.

  11. Intraclade heterogeneity in nitrogen utilization by marine prokaryotes revealed using stable isotope probing coupled with tag sequencing (Tag-SIP

    Directory of Open Access Journals (Sweden)

    Michael Morando

    2016-12-01

    Full Text Available Nitrogen can greatly influence the structure and productivity of microbial communities through its relative availability and form. However, roles of specific organisms in the uptake of different nitrogen species remain poorly characterized. Most studies seeking to identify agents of assimilation have been correlative, indirectly linking activity measurements (e.g., nitrate uptake with the presence or absence of biological markers, particularly functional genes and their transcripts. Evidence is accumulating of previously underappreciated functional diversity in major microbial subpopulations, which may confer physiological advantages under certain environmental conditions leading to ecotype divergence. This microdiversity further complicates our view of genetic variation in environmental samples requiring the development of more targeted approaches. Here, next-generation tag sequencing was successfully coupled with stable isotope probing (Tag-SIP to assess the ability of individual phylotypes to assimilate a particular N source. Our results provide the first direct evidence of nitrate utilization by organisms thought to lack the genes required for this process including the heterotrophic clades SAR11 and the Archaeal Marine Group II (MG-II. We also provide new direct evidence of in situ nitrate utilization by the cyanobacterium Prochlorococcus in support of recent findings. Furthermore, these results revealed widespread functional heterogeneity, i.e. different levels of N assimilation within clades, likely reflecting niche partitioning by ecotypes. The addition of nitrate utilization to ecosystem and ecosystem models by these globally dominant clades will likely improve the mechanistic accuracy of these models.

  12. The Use of Twitter by Radiology Journals: An Analysis of Twitter Activity and Impact Factor.

    Science.gov (United States)

    Kelly, Brendan S; Redmond, Ciaran E; Nason, Gregory J; Healy, Gerard M; Horgan, Niall A; Heffernan, Eric J

    2016-11-01

    Medical journals use social media as a means to disseminate new research and interact with readers. The microblogging site Twitter is one such platform. The aim of this study was to analyze the recent use of Twitter by the leading radiology journals. The top 50 journals by Impact Factor were included. Twitter profiles associated with these journals, or their corresponding societies, were identified. Whether each journal used other social media platforms was also recorded. Each Twitter profile was analyzed over a one-year period, with data collected via Twitonomy software. Klout scores of social media influence were calculated. Results were analyzed in SPSS using Student's t test, Fisher contingency tables, and Pearson correlations to identify any association between social media interaction and Impact Factors of journals. Fourteen journals (28%) had dedicated Twitter profiles. Of the 36 journals without dedicated Twitter profiles, 25 (50%) were associated with societies that had profiles, leaving 11 (22%) journals without a presence on Twitter. The mean Impact Factor of all journals was 3.1 ± 1.41 (range, 1.7-6.9). Journals with Twitter profiles had higher Impact Factors than those without (mean, 3.37 vs 2.14; P Twitter profiles and those associated with affiliated societies (P = .47). Since joining Twitter, 7 of the 11 journals (64%) experienced increases in Impact Factor. A greater number of Twitter followers was correlated with higher journal Impact Factor (R 2  = 0.581, P = .029). The investigators assessed the prevalence and activity of the leading radiology journals on Twitter. Radiology journals with Twitter profiles have higher Impact Factors than those without profiles, and the number of followers of a journal's Twitter profile is positively associated with Impact Factor. Copyright © 2016 American College of Radiology. Published by Elsevier Inc. All rights reserved.

  13. Isotopic fractionation and profile evolution of a melting snowcover

    Institute of Scientific and Technical Information of China (English)

    周石硚; 中尾正义; 桥本重将; 坂井亚规子; 成田英器; 石川信敬

    2001-01-01

    Successive snow pits were dug intensively in a melting snowcover. Water was successfully separated from snow grains in the field for the first time. By measuring δ18O values of water and snow grain samples as well as comparing isotopic profiles, it is found that meltwater percolating down in snow develops quick and clear isotopic fractionation with snow grains, but exerts no clear impact on the δ18O profile of the snowcover through which the meltwater percolates.

  14. Genome-wide identification, characterization, and expression profile of aquaporin gene family in flax (Linum usitatissimum).

    Science.gov (United States)

    Shivaraj, S M; Deshmukh, Rupesh K; Rai, Rhitu; Bélanger, Richard; Agrawal, Pawan K; Dash, Prasanta K

    2017-04-27

    Membrane intrinsic proteins (MIPs) form transmembrane channels and facilitate transport of myriad substrates across the cell membrane in many organisms. Majority of plant MIPs have water transporting ability and are commonly referred as aquaporins (AQPs). In the present study, we identified aquaporin coding genes in flax by genome-wide analysis, their structure, function and expression pattern by pan-genome exploration. Cross-genera phylogenetic analysis with known aquaporins from rice, arabidopsis, and poplar showed five subgroups of flax aquaporins representing 16 plasma membrane intrinsic proteins (PIPs), 17 tonoplast intrinsic proteins (TIPs), 13 NOD26-like intrinsic proteins (NIPs), 2 small basic intrinsic proteins (SIPs), and 3 uncharacterized intrinsic proteins (XIPs). Amongst aquaporins, PIPs contained hydrophilic aromatic arginine (ar/R) selective filter but TIP, NIP, SIP and XIP subfamilies mostly contained hydrophobic ar/R selective filter. Analysis of RNA-seq and microarray data revealed high expression of PIPs in multiple tissues, low expression of NIPs, and seed specific expression of TIP3 in flax. Exploration of aquaporin homologs in three closely related Linum species bienne, grandiflorum and leonii revealed presence of 49, 39 and 19 AQPs, respectively. The genome-wide identification of aquaporins, first in flax, provides insight to elucidate their physiological and developmental roles in flax.

  15. Analysis of the ozone profile specifications in the WRF-ARW model and their impact on the simulation of direct solar radiation

    Directory of Open Access Journals (Sweden)

    A. Montornès

    2015-03-01

    Full Text Available Although ozone is an atmospheric gas with high spatial and temporal variability, mesoscale numerical weather prediction (NWP models simplify the specification of ozone concentrations used in their shortwave schemes by using a few ozone profiles. In this paper, a two-part study is presented: (i an evaluation of the quality of the ozone profiles provided for use with the shortwave schemes in the Advanced Research version of the Weather Research and Forecasting (WRF-ARW model and (ii an assessment of the impact of deficiencies in those profiles on the performance of model simulations of direct solar radiation. The first part compares simplified data sets used to specify the total ozone column in six schemes (i.e., Goddard, New Goddard, RRTMG, CAM, GFDL and Fu–Liou–Gu with the Multi-Sensor Reanalysis data set during the period 1979–2008 examining the latitudinal, longitudinal and seasonal limitations in the ozone profile specifications of each parameterization. The results indicate that the maximum deviations are over the poles and show prominent longitudinal patterns in the departures due to the lack of representation of the patterns associated with the Brewer–Dobson circulation and the quasi-stationary features forced by the land–sea distribution, respectively. In the second part, the bias in the simulated direct solar radiation due to these deviations from the simplified spatial and temporal representation of the ozone distribution is analyzed for the New Goddard and CAM schemes using the Beer–Lambert–Bouguer law and for the GFDL using empirical equations. For radiative applications those simplifications introduce spatial and temporal biases with near-zero departures over the tropics throughout the year and increasing poleward with a maximum in the high middle latitudes during the winter of each hemisphere.

  16. RNA-Based Stable Isotope Probing Suggests Allobaculum spp. as Particularly Active Glucose Assimilators in a Complex Murine Microbiota Cultured In Vitro

    Directory of Open Access Journals (Sweden)

    Elena Herrmann

    2017-01-01

    Full Text Available RNA-based stable isotope probing (RNA-SIP and metabolic profiling were used to detect actively glucose-consuming bacteria in a complex microbial community obtained from a murine model system. A faeces-derived microbiota was incubated under anaerobic conditions for 0, 2, and 4 h with 40 mM [U13C]glucose. Isopycnic density gradient ultracentrifugation and fractionation of isolated RNA into labeled and unlabeled fractions followed by 16S rRNA sequencing showed a quick adaptation of the bacterial community in response to the added sugar, which was dominated by unclassified Lachnospiraceae species. Inspection of distinct fractions of isotope-labeled RNA revealed Allobaculum spp. as particularly active glucose utilizers in the system, as the corresponding RNA showed significantly higher proportions among the labeled RNA. With time, the labeled sugar was used by a wider spectrum of faecal bacteria. Metabolic profiling indicated rapid fermentation of [U13C]glucose, with lactate, acetate, and propionate being the principal 13C-labeled fermentation products, and suggested that “cross-feeding” occurred in the system. RNA-SIP combined with metabolic profiling of 13C-labeled products allowed insights into the microbial assimilation of a general model substrate, demonstrating the appropriateness of this technology to study assimilation processes of nutritionally more relevant substrates, for example, prebiotic carbohydrates, in the gut microbiota of mice as a model system.

  17. Imprint of primordial non-Gaussianity on dark matter halo profiles

    Energy Technology Data Exchange (ETDEWEB)

    Dizgah, Azadeh Moradinezhad; Dodelson, Scott; Riotto, Antonio

    2013-09-01

    We study the impact of primordial non-Gaussianity on the density profile of dark matter halos by using the semi-analytical model introduced recently by Dalal {\\it et al.} which relates the peaks of the initial linear density field to the final density profile of dark matter halos. Models with primordial non-Gaussianity typically produce an initial density field that differs from that produced in Gaussian models. We use the path-integral formulation of excursion set theory to calculate the non-Gaussian corrections to the peak profile and derive the statistics of the peaks of non-Gaussian density field. In the context of the semi-analytic model for halo profiles, currently allowed values for primordial non-Gaussianity would increase the shapes of the inner dark matter profiles, but only at the sub-percent level except in the very innermost regions.

  18. Medical professionalism: an experimental look at physicians’ Facebook profiles

    Directory of Open Access Journals (Sweden)

    Joseph W. Clyde

    2014-06-01

    Full Text Available Background: Use of social networking services (SNS is on the rise. While many users sign in for personal purposes, it is not uncommon for professionals to connect over SNSs with clients, students, and patients. Methods: The present study used an experimental approach to examine how medical doctors’ SNS profiles impacted potential patients’ impressions of professionalism. Participants (N=250 students were randomly assigned to view one of six Facebook profiles. Profiles were populated with 1 solely professional material, 2 personal material that was strictly healthy, or 3 personal material that included unhealthy behavior. Profiles portrayed a male or female physician resulting in a total of six experimental conditions. Medical professionalism was measured with the First Impressions of Medical Professionalism (FIMP scale, specifically developed for this study. Results: There was a large and statistically significant main effect for profile type, F(2, 250=54.77, p<0.001, ηp2=0.31. Post hoc tests indicated that personal profiles that contained healthy behavior were rated as most professional followed by profiles with strictly professional content. Personal unhealthy profiles were rated as least professional. Additionally, female profiles consistently received higher professionalism ratings across all three profile types [F(1, 250=5.04, p=0.026, ηp2=0.02]. Conclusion: Our results suggest that a physician's SNS profile affects a patient's perception of that physician's medical professionalism. A personal, healthy profile may augment a patient's perception of that physician's character virtues if the profile content upholds the decorum of the medical field.

  19. Applications of nutrient profiling: potential role in diet-related chronic disease prevention and the feasibility of a core nutrient-profiling system.

    Science.gov (United States)

    Sacks, G; Rayner, M; Stockley, L; Scarborough, P; Snowdon, W; Swinburn, B

    2011-03-01

    A number of different nutrient-profiling models have been proposed and several applications of nutrient profiling have been identified. This paper outlines the potential role of nutrient-profiling applications in the prevention of diet-related chronic disease (DRCD), and considers the feasibility of a core nutrient-profiling system, which could be modified for purpose, to underpin the multiple potential applications in a particular country. The 'Four 'P's of Marketing' (Product, Promotion, Place and Price) are used as a framework for identifying and for classifying potential applications of nutrient profiling. A logic pathway is then presented that can be used to gauge the potential impact of nutrient-profiling interventions on changes in behaviour, changes in diet and, ultimately, changes in DRCD outcomes. The feasibility of a core nutrient-profiling system is assessed by examining the implications of different model design decisions and their suitability to different purposes. There is substantial scope to use nutrient profiling as part of the policies for the prevention of DRCD. A core nutrient-profiling system underpinning the various applications is likely to reduce discrepancies and minimise the confusion for regulators, manufacturers and consumers. It seems feasible that common elements, such as a standard scoring method, a core set of nutrients and food components, and defined food categories, could be incorporated as part of a core system, with additional application-specific criteria applying. However, in developing and in implementing such a system, several country-specific contextual and technical factors would need to be balanced.

  20. Socioeconomic profile of Clark County, Nevada: Community services inventory

    International Nuclear Information System (INIS)

    1986-09-01

    The Nevada Nuclear Waste Storage Investigations Project is preparing socioeconomic profiles of Clark County, Nevada, and communities in Clark County that could be affected by siting, construction, operation, and decommissioning of a high-level nuclear waste repository at Yucca Mountain, located in Nye County. These profiles serve as a data base for evaluating local community service impacts; store existing socioeconomic data in a uniform, readily accessible format; identify the need for additional data; and assist in developing a plan for monitoring and mitigating any significant adverse impacts that may be associated with site characterization and potential repository development. This element of the socioeconomic profiles contains an inventory of community services provided by local, county, and state agencies and volunteer organizations to residents of Las Vegas, North Las Vegas, Henderson, Boulder City, Indian Springs, and unincorporated areas of the county. Services inventoried include housing, growth management, general government, education, police protection, transportation networks, public clinics, private health personnel, parks and recreation, social services, libraries, ambulances, electric power, natural gas, water, sewers and wastewater treatment, solid waste, and fire protection. The report includes a summary overview of service providers in Clark County, discussions of the services provided to residents of communities in Clark County that may be affected by Project activities, and a description of service providers whose service areas are not limited to the incorporated areas of Clark County. Data presented in this profile were collected through March of 1985. Data collection efforts are ongoing and this profile will be updated periodically

  1. Exploring the impact of network tariffs on household electricity expenditures using load profiles and socio-economic characteristics

    Science.gov (United States)

    Azarova, Valeriya; Engel, Dominik; Ferner, Cornelia; Kollmann, Andrea; Reichl, Johannes

    2018-04-01

    Growing self-generation and storage are expected to cause significant changes in residential electricity utilization patterns. Commonly applied volumetric network tariffs may induce imbalance between different groups of households and their respective contribution to recovering the operating costs of the grid. Understanding consumer behaviour and appliance usage together with socio-economic factors can help regulatory authorities to adapt network tariffs to new circumstances in a fair way. Here, we assess the effects of 11 network tariff scenarios on household budgets using real load profiles from 765 households. Thus we explore the possibly disruptive impact of applying peak-load-based tariffs on the budgets of households when they have been mainly charged for consumed volumes before. Our analysis estimates the change in household network expenditure for different combinations of energy, peak and fixed charges, and can help to design tariffs that recover the costs needed for the sustainable operation of the grid.

  2. Profile variation impact on FIB cross-section metrology

    Science.gov (United States)

    Cordes, Aaron; Bunday, Benjamin; Nadeau, Jim

    2012-03-01

    The focused ion beam (FIB) milling tool is an important component of reference metrology and process characterization, both as a supporting instrument for bulk sample preparation before forwarding to the transmission electron microscope (TEM) and other instruments and as an in situ measurement instrument using angled scanning electron microscopy. As features grow denser, deeper and more demanding, full-profile reference metrology is needed, and this methodology will only grow in importance. Thus, the ability to extract accurate dimensional and profile information out of the crosssectional faces produced by FIB milling is critical. For features that demonstrate perfect symmetry in the plane of the cross section, analyzing images and extracting metrology data are straightforward. However, for industrial materials, symmetry is not a safe assumption: as features shrink, the line edge and sidewall roughness increases as a percentage of the overall feature dimension. Furthermore, with the introduction of more complex architectures such as 3D memory and FinFETs, the areas of greatest interest, such as the intersections of wrap-around gates, cannot be assumed to be symmetrical in any given plane if cut placement is not precisely controlled. Therefore it is important to establish the exact location and repeatability of the cross-section plane, both in terms of coordinate placement and effective angle of the milled surface. To this end, we prepared designed-in line edge roughness samples in the Albany Nanotech facility using SEMATECH's AMAG6 metrology reticle. The samples were thoroughly characterized before being milled by a non-destructive, sidewall-scanning atomic force microscope (AFM). These samples are then milled and measured under varying process and setup parameters using a single-beam FIB with angled SEM. We established methodologies that allow precise alignment of the cut planes of slice-and-view FIB milling to 3D-AFM scan lines to compare repeated sections

  3. Celebrating 25 Years of Student Mentoring | Poster

    Science.gov (United States)

    Most employees of NCI at Frederick have heard of the Werner H. Kirsten Student Intern Program (WHK SIP). The reason is simple—it has been wildly successful. And on Friday, April 22, the program will celebrate 25 years of mentoring and learning at the WHK SIP 25th Anniversary Symposium and Awards Ceremony. During the morning session, several former interns will talk about the impact that the WHK program has had on their lives. The afternoon session will begin with a panel of current and former mentors who will answer questions from students interested in the program and staff members interested in becoming mentors. Read more...

  4. Exploration of one-dimensional plasma current density profile for K-DEMO steady-state operation

    Energy Technology Data Exchange (ETDEWEB)

    Kang, J.S. [Seoul National University, Seoul 151-742 (Korea, Republic of); Jung, L. [National Fusion Research Institute, Daejeon (Korea, Republic of); Byun, C.-S.; Na, D.H.; Na, Y.-S. [Seoul National University, Seoul 151-742 (Korea, Republic of); Hwang, Y.S., E-mail: yhwang@snu.ac.kr [Seoul National University, Seoul 151-742 (Korea, Republic of)

    2016-11-01

    Highlights: • One-dimensional current density and its optimization for the K-DEMO are explored. • Plasma current density profile is calculated with an integrated simulation code. • The impact of self and external heating profiles is considered self-consistently. • Current density is identified as a reference profile by minimizing heating power. - Abstract: Concept study for Korean demonstration fusion reactor (K-DEMO) is in progress, and basic design parameters are proposed by targeting high magnetic field operation with ITER-sized machine. High magnetic field operation is a favorable approach to enlarge relative plasma performance without increasing normalized beta or plasma current. Exploration of one-dimensional current density profile and its optimization process for the K-DEMO steady-state operation are reported in this paper. Numerical analysis is conducted with an integrated plasma simulation code package incorporating a transport code with equilibrium and current drive modules. Operation regimes are addressed with zero-dimensional system analysis. One-dimensional plasma current density profile is calculated based on equilibrium, bootstrap current analysis, and thermal transport analysis. The impact of self and external heating profiles on those parameters is considered self-consistently, where thermal power balance and 100% non-inductive current drive are the main constraints during the whole exploration procedure. Current and pressure profiles are identified as a reference steady-state profile by minimizing the external heating power with desired fusion power.

  5. [Safety profile of dolutegravir].

    Science.gov (United States)

    Rivero, Antonio; Domingo, Pere

    2015-03-01

    Integrase inhibitors are the latest drug family to be added to the therapeutic arsenal against human immunodeficiency virus infection. Drugs in this family that do not require pharmacological boosting are characterized by a very good safety profile. The latest integrase inhibitor to be approved for use is dolutegravir. In clinical trials, dolutegravir has shown an excellent tolerability profile, both in antiretroviral-naïve and previously treated patients. Discontinuation rates due to adverse effects were 2% and 3%, respectively. The most frequent adverse effects were nausea, headache, diarrhea and sleep disturbance. A severe hypersensitivity reaction has been reported in only one patient. In patients coinfected with hepatropic viruses, the safety profile is similar to that in patients without coinfection. The lipid profile of dolutegravir is similar to that of raltegravir and superior to those of Atripla® and darunavir/ritonavir. Dolutegravir induces an early, predictable and non-progressive increase in serum creatinine of around 10% of baseline values in treatment-naïve patients and of 14% in treatment-experienced patients. This increase is due to inhibition of tubular creatinine secretion through the OCT2 receptor and does not lead to a real decrease in estimated glomerular filtration rate with algorithms that include serum creatinine. The effect of the combination of dolutegravir plus Kivexa(®) on biomarkers of bone remodeling is lower than that of Atripla(®). Dolutegravir has an excellent tolerability profile with no current evidence of long-term adverse effects. Its use is accompanied by an early and non-progressive increase in serum creatinine due to OCT2 receptor inhibition. In combination with abacavir/lamivudine, dolutegravir has a lower impact than enofovir/emtricitabine/efavirenz on bone remodelling markers. Copyright © 2015 Elsevier España, S.L.U. All rights reserved.

  6. Differences in responses to the Oral Health Impact Profile (OHIP14 used as a questionnaire or in an interview

    Directory of Open Access Journals (Sweden)

    Paula Cristina Brolezi de Sousa

    2009-12-01

    Full Text Available The objective of this study was to compare the completion rates and performance of the Brazilian version of the Oral Health Impact Profile (OHIP14 when applied as an interview or in its original self-reported form. A convenience sample of 74 adult patients was selected in a Dental Clinic (University of Araras, Brazil. One examiner administered the instrument in both formats to participants with an interval of 2 weeks between each administration. Data about dental health condition and socioeconomic status were collected and associated with total OHIP14 scores in both formats using linear regression analyses. No differences were found in the total scores and in each subscale of the OHIP14 according to the form of administration. Higher values of completion were found in the interview format. More severe impacts were recorded in the interview format than in the questionnaire format. Higher values of total OHIP-14 scores in both formats were related to the presence of dental caries. Total OHIP14 scores were not influenced by the method of administration. However, the use of the OHIP14 in the questionnaire format may result in lower completion rates and loss of data.

  7. Personality Profiles of Cultures: Aggregate Personality Traits

    Czech Academy of Sciences Publication Activity Database

    McCrae, R.R.; Terracciano, A.; Leibovich, N.B.; Schmidt, V.; Shakespeare-Finch, J.; Neubauer, A.; De Fruyt, F.; Munyae, M.; Flores-Mendoza, C.; Dahourou, D.; Ayearst, L. E.; Trobst, K.K.; Alcalay, L.; Simonetti, F.; Bratko, D.; Marušic´, I.; Hřebíčková, Martina; Mortensen, L.K.; Jensen, H.H.; Allik, J.; Realo, A.; Sineshaw, T.; Rolland, J-P.; Petot, J.M.; Camart, N.; Angleitner, A.; Ostendorf, F.; Yik, M.; Jónsson, F. H.; Pramila, V.S.; Halim, M. S.; Jaya, A.; Shahriar Shahidi, S.; Barbaranelli, C.; Shimonaka, Y.; Gakuin, B.; Nakazato, K.; Abdel Khalek, A. M.; Alansari, B. M.; Khoury, B.; Mastor, K.A.; Falzon, R.; Lauri, M.A.; Borg Cunen, M.A.; Scicluna Calleja, S.; Diaz-Loving, R.; Ghayur, M. A.; Fischer, R.; Oluyinka Ojedokun, A.; Prentice, G.; McRorie, M.; Wang, L.; Reátegui, N.; Brunner-Sciarra, M.; del Pilar, G.E.H.; Sekowski, A.; Klinkosz, W.; Pedroso de Lima, M.; Porrata, J.; Martin, T.A.; Ficková, E.; Adamovová, L.; Rus, V.R.; Podobnik, N.; Zupancic, A.; Ahn, H.; Ahn, Ch.; Avia, M. D.; Sánchez-Bernardos, M.L.; Ruch, W.; Rossier, J.; Chittcharat, N.; Gülgöz, S.; Nansubuga, F.; Smith, P.B.; Matsumoto, D.; Diener, E.; Beer, A.; Humrichouse, J.; Budzinski, L.; Oishi, S.; Knežević, G.; Djuric Jocic, D.

    2005-01-01

    Roč. 89, č. 3 (2005), s. 407-425 ISSN 0022-3514 R&D Projects: GA ČR GA406/01/1507 Institutional research plan: CEZ:AV0Z70250504 Keywords : personality * five-factor model * cross - cultural * culture-level analyses * culture profiles Subject RIV: AN - Psychology Impact factor: 4.211, year: 2005

  8. Occupational Heat Stress Profiles in Selected Workplaces in India

    OpenAIRE

    Venugopal, Vidhya; Chinnadurai, Jeremiah S.; Lucas, Rebekah A. I.; Kjellstrom, Tord

    2016-01-01

    Health and productivity impacts from occupational heat stress have significant ramifications for the large workforce of India. This study profiled occupational heat stress impacts on the health and productivity of workers in select organized and unorganized Indian work sectors. During hotter and cooler seasons, Wet Bulb Globe Temperatures (WBGT) were used to quantify the risk of heat stress, according to International workplace guidelines. Questionnaires assessed workers' perceived health and...

  9. Influence of common preanalytical variations on the metabolic profile of serum samples in biobanks

    International Nuclear Information System (INIS)

    Fliniaux, Ophélie; Gaillard, Gwenaelle; Lion, Antoine; Cailleu, Dominique; Mesnard, François; Betsou, Fotini

    2011-01-01

    A blood pre-centrifugation delay of 24 h at room temperature influenced the proton NMR spectroscopic profiles of human serum. A blood pre-centrifugation delay of 24 h at 4°C did not influence the spectroscopic profile as compared with 4 h delays at either room temperature or 4°C. Five or ten serum freeze–thaw cycles also influenced the proton NMR spectroscopic profiles. Certain common in vitro preanalytical variations occurring in biobanks may impact the metabolic profile of human serum.

  10. Impact of Short-Term Training in Social Cognition in Preschoolers with Externalizing Behavior

    Science.gov (United States)

    Houssa, Marine; Jacobs, Emilie; Nader-Grosbois, Nathalie

    2017-01-01

    In two experimental and exploratory studies, we wanted to test the differentiated effects on preschoolers with externalizing behavior (EB) of two short-term social information processing (SIP) and Theory of Mind (ToM) training sessions, in comparison with typically developing (TD) preschoolers or with preschoolers with EB whom didn't receive…

  11. Quantifying soil profile change caused by land use in central Missouri loess hillslopes

    Science.gov (United States)

    Samuel J. Indorante; John M. Kabrick; Brad D. Lee; Jon M. Maatta

    2014-01-01

    Three major challenges are present when studying anthropogenic impacts on soil profile properties: (i) site selection; (ii) sampling and modeling native and cultivated soil-landscape relationships; and (iii) graphically and statistically comparing native and cultivated sites to model soil profile changes. This study addressed those challenges by measuring and modeling...

  12. Assimilation of NUCAPS Retrieved Profiles in GSI for Unique Forecasting Applications

    Science.gov (United States)

    Berndt, Emily Beth; Zavodsky, Bradley; Srikishen, Jayanthi; Blankenship, Clay

    2015-01-01

    Hyperspectral IR profiles can be assimilated in GSI as a separate observation other than radiosondes with only changes to tables in the fix directory. Assimilation of profiles does produce changes to analysis fields and evidenced by: Innovations larger than +/-2.0 K are present and represent where individual profiles impact the final temperature analysis.The updated temperature analysis is colder behind the cold front and warmer in the warm sector. The updated moisture analysis is modified more in the low levels and tends to be drier than the original model background Analysis of model output shows: Differences relative to 13-km RAP analyses are smaller when profiles are assimilated with NUCAPS errors. CAPE is under-forecasted when assimilating NUCAPS profiles, which could be problematic for severe weather forecasting Refining the assimilation technique to incorporate an error covariance matrix and creating a separate GSI module to assimilate satellite profiles may improve results.

  13. Shock compression profiles in ceramics

    Energy Technology Data Exchange (ETDEWEB)

    Grady, D.E.; Moody, R.L.

    1996-03-01

    An investigation of the shock compression properties of high-strength ceramics has been performed using controlled planar impact techniques. In a typical experimental configuration, a ceramic target disc is held stationary, and it is struck by plates of either a similar ceramic or by plates of a well-characterized metal. All tests were performed using either a single-stage propellant gun or a two-stage light-gas gun. Particle velocity histories were measured with laser velocity interferometry (VISAR) at the interface between the back of the target ceramic and a calibrated VISAR window material. Peak impact stresses achieved in these experiments range from about 3 to 70 GPa. Ceramics tested under shock impact loading include: Al{sub 2}O{sub 3}, AlN, B{sub 4}C, SiC, Si{sub 3}N{sub 4}, TiB{sub 2}, WC and ZrO{sub 2}. This report compiles the VISAR wave profiles and experimental impact parameters within a database-useful for response model development, computational model validation studies, and independent assessment of the physics of dynamic deformation on high-strength, brittle solids.

  14. Occupational factors and subsequent major depressive and generalized anxiety disorders in the prospective French national SIP study.

    Science.gov (United States)

    Niedhammer, Isabelle; Malard, Lucile; Chastang, Jean-François

    2015-02-28

    The literature has been extensive on the associations between psychosocial work factors and mental health. Nevertheless, the studies using prospective design, various concepts and more than one measurement point in time for these factors and diagnostic interview to assess mental disorders remain seldom in the literature. This study is an attempt to fill the gap in this topic. The study was based on a national representative sample of 4717 workers of the French working population (SIP survey), interviewed in 2006 and reinterviewed again in 2010 and free of mental disorders at baseline. Psychosocial work factors, measured in both 2006 and 2010, included: psychological demands, decision latitude, social support, reward, emotional demands, role conflict, ethical conflict, tensions with the public, job insecurity and work-life imbalance. Other occupational factors related to working time/hours and physical work environment were also studied. Major depressive (MDD) and generalized anxiety disorders (GAD) were measured using a standardised diagnostic interview (MINI). Covariates were age, occupation, marital status, having a child under 3 y, social support outside work and stressful life events. Multivariate analyses were performed using weighted logistic regression models. Using models taking all occupational factors into account simultaneously, low reward and job insecurity predicted MDD. Psychological demands, low reward, emotional demands and job insecurity were predictive of GAD. The more frequent the exposure to job insecurity, the higher the risk of MDD and GAD, and the more frequent the exposure to psychological demands and low reward, the higher the risk of GAD. No effect was observed for repeated exposure to occupational factors. Classical and emergent psychosocial work factors were predictive factors of depression and anxiety with dose-response associations in terms of frequency of exposure. More attention may be needed on emergent psychosocial work factors and

  15. Influence of common preanalytical variations on the metabolic profile of serum samples in biobanks

    Energy Technology Data Exchange (ETDEWEB)

    Fliniaux, Ophelie [University of Picardie Jules Verne, Laboratoire de Phytotechnologie EA 3900-BioPI (France); Gaillard, Gwenaelle [Biobanque de Picardie (France); Lion, Antoine [University of Picardie Jules Verne, Laboratoire de Phytotechnologie EA 3900-BioPI (France); Cailleu, Dominique [Batiment Serres-Transfert, rue de Mai/rue Dallery, Plateforme Analytique (France); Mesnard, Francois, E-mail: francois.mesnard@u-picardie.fr [University of Picardie Jules Verne, Laboratoire de Phytotechnologie EA 3900-BioPI (France); Betsou, Fotini [Integrated Biobank of Luxembourg (Luxembourg)

    2011-12-15

    A blood pre-centrifugation delay of 24 h at room temperature influenced the proton NMR spectroscopic profiles of human serum. A blood pre-centrifugation delay of 24 h at 4 Degree-Sign C did not influence the spectroscopic profile as compared with 4 h delays at either room temperature or 4 Degree-Sign C. Five or ten serum freeze-thaw cycles also influenced the proton NMR spectroscopic profiles. Certain common in vitro preanalytical variations occurring in biobanks may impact the metabolic profile of human serum.

  16. World Energy Data System (WENDS). Volume VI. International agreement profiles

    Energy Technology Data Exchange (ETDEWEB)

    None

    1979-06-01

    The World Energy Data System contains organized data on those countries and international organizations that may have critical impact on world energy. The international agreement profiles in WENDS are all energy-related and are organized by energy technology. These are: coal; conservation; fusion; geothermal; nuclear fission; oil, gas, and shale; solar, wind, and ocean thermal; and other (cooperation in electrical power equipment acquisition, energy, energy research, etc.). The agreement profiles are accessible by energy technology and alphabetically by country.

  17. Asymmetry of Hβ Stark profiles in T-tube hydrogen plasma

    International Nuclear Information System (INIS)

    Djurovic, S.; Nikolic, D.; Savic, I.; Soerge, S.; Demura, A. V.

    2005-01-01

    The whole Balmer H β line profiles are studied in detail experimentally in the T-tube discharge for the wide range of plasma parameters. Besides the common one, two additional parameters are introduced to characterize the asymmetry behavior of the experimental Stark profiles with the reference point chosen in the center of the line. The experimental data are analyzed and benchmarked versus the simple theoretical model based on the effects of microfield nonuniformity and electron impact shifts

  18. Shear wave profiles from surface wave inversion: the impact of uncertainty on seismic site response analysis

    International Nuclear Information System (INIS)

    Boaga, J; Vignoli, G; Cassiani, G

    2011-01-01

    Inversion is a critical step in all geophysical techniques, and is generally fraught with ill-posedness. In the case of seismic surface wave studies, the inverse problem can lead to different equivalent subsoil models and consequently to different local seismic response analyses. This can have a large impact on an earthquake engineering design. In this paper, we discuss the consequences of non-uniqueness of surface wave inversion on seismic responses, with both numerical and experimental data. Our goal is to evaluate the consequences on common seismic response analysis in the case of different impedance contrast conditions. We verify the implications of inversion uncertainty, and consequently of data information content, on realistic local site responses. A stochastic process is used to generate a set of 1D shear wave velocity profiles from several specific subsurface models. All these profiles are characterized as being equivalent, i.e. their responses, in terms of a dispersion curve, are compatible with the uncertainty in the same surface wave data. The generated 1D shear velocity models are then subjected to a conventional one-dimensional seismic ground response analysis using a realistic input motion. While recent analyses claim that the consequences of surface wave inversion uncertainties are very limited, our test points out that a relationship exists between inversion confidence and seismic responses in different subsoils. In the case of regular and relatively smooth increase of shear wave velocities with depth, as is usual in sedimentary plains, our results show that the choice of a specific model among equivalent solutions strongly influences the seismic response. On the other hand, when the shallow subsoil is characterized by a strong impedance contrast (thus revealing a characteristic soil resonance period), as is common in the presence of a shallow bedrock, equivalent solutions provide practically the same seismic amplification, especially in the

  19. Golf tourism in South Africa: Profiling attendees at a major ...

    African Journals Online (AJOL)

    Golf tourism in South Africa: Profiling attendees at a major championship event. ... from the less developed and developing context from an impact perspective. ... participated in various tourism activities that contributed to the local economy.

  20. Monte Carlo simulation of single accident airport risk profile

    Science.gov (United States)

    1979-01-01

    A computer simulation model was developed for estimating the potential economic impacts of a carbon fiber release upon facilities within an 80 kilometer radius of a major airport. The model simulated the possible range of release conditions and the resulting dispersion of the carbon fibers. Each iteration of the model generated a specific release scenario, which would cause a specific amount of dollar loss to the surrounding community. By repeated iterations, a risk profile was generated, showing the probability distribution of losses from one accident. Using accident probability estimates, the risks profile for annual losses was derived. The mechanics are described of the simulation model, the required input data, and the risk profiles generated for the 26 large hub airports.

  1. Short bowel patients treated for two years with glucagon-like peptide 2 (GLP-2): compliance, safety, and effects on quality of life

    DEFF Research Database (Denmark)

    Jeppesen, P B; Lund, P; Gottschalck, I B

    2009-01-01

    BACKGROUND AND AIMS: Glucagon-like peptide 2 (GLP-2) has been shown to improve intestinal absorption in short bowel syndrome (SBS) patients in a short-term study. This study describes safety, compliance, and changes in quality of life in 11 SBS patients at baseline, week 13, 26, and 52 during two...... years of subcutaneous GLP-2 treatment, 400 microgram TID, intermitted by an 8-week washout period. METHODS: Safety and compliance was evaluated during the admissions. The Sickness Impact Profile (SIP), Short Form 36 (SF 36), and Inflammatory Bowel Disease Questionnaire (IBDQ) evaluated quality of life......-ascendo-anastomosis. The investigator excluded a patient due to unreliable feedback. Stoma nipple enlargement was seen in all 9 jejunostomy patients. Reported GLP-2 compliance was excellent (>93%). GLP-2 improved the overall quality of life VAS-score (4.1 +/- 2.8 cm versus 6.0 +/- 2.4 cm, P

  2. Urinary steroid profile in females - the impact of menstrual cycle and emergency contraceptives.

    Science.gov (United States)

    Mullen, Jenny E; Thörngren, John-Olof; Schulze, Jenny J; Ericsson, Magnus; Gårevik, Nina; Lehtihet, Mikael; Ekström, Lena

    2017-07-01

    Today's doping tests involving longitudinal monitoring of steroid profiles are difficult in women. Women have more complex hormonal fluctuations than men and commonly take drugs such as hormonal contraceptives that are shown to affect biomarkers used in these doping tests. In this study, we followed six women's urinary steroid profile during one menstrual cycle, including both glucuronides and sulfate conjugated fractions. Additionally, we studied what happens to the steroidal module of the Athlete Biological Passport (ABP) after administration of an emergency contraceptive (levonorgestrel, NorLevo®). The study shows that there are large individual variations in all metabolites included in the ABP and that the administration of emergency contraceptives may lead to suspicious steroid profile findings in the ABP. Urinary epitestosterone concentration increased during the menstrual cycle, leading to a decrease in the testosterone/epitestosterone ratio. The ratios followed in the ABP varied widely throughout the menstrual cycle, the coefficient of variation (CV) ranging from 4 to 99%. There was a 3-fold decrease in epitestosterone 24 h post administration of the emergency contraceptive pill and androsterone, etiocholanolone, and 5β- androstan-3α,17β-diol concentrations decreased about 2-fold. When analyzed with the ABP software, one of the six women had an atypical profile after taking the emergency contraceptive. Furthermore, we could not find any alterations in excretion routes (i.e., if the metabolites are excreted as glucuronide or sulfate conjugates) during the menstrual cycle or after administration of emergency contraceptive, indicating no direct effect on phase II enzymes. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  3. Shock Induced Melting in Aluminum: Wave Profile Measurements

    Energy Technology Data Exchange (ETDEWEB)

    Chhabildas, Lalit C.; Furnish, Michael D.; Reinhart, William D.

    1999-06-23

    We have developed launch capabilities that can propel macroscopic plates to hypervelocities (8 to 16 km/s). This capability has been used to determine the first time-resolved wave profile measurements using velocity interferometry techniques at impact velocities of 10 km/s. These measurements show that alu- minum continues to exhibit normal release behavior to 161 GPa with complete loss of strength in the shocked state. Results of these experiments are discussed and compared with the results of lower pressure experi- ments conducted at lower impact velocities.

  4. Impact of the layout of the ITER Radial Neutron Camera in-port system on the measurement of the neutron emissivity profile

    International Nuclear Information System (INIS)

    Marocco, D.; Moro, F.; Esposito, B.; Brolatti, G.; Villari, R.; Salasca, S.; Cantone, B.

    2013-01-01

    Highlights: ► MCNP ITER model ‘Alite-4′ has been updated with the new Port Plug structure (three vertical drawers). ► Two different layouts for the Radial Neutron Camera (RNC) in-vessel system have been considered. ► The impact of both layouts on the RNC diagnostic performance has been assessed. ► The analysis provides useful information for a proper integration of the RNC in the EPP1. -- Abstract: The Radial Neutron Camera (RNC), located in the ITER Equatorial Port Plug 1 (EPP1), is designed to provide the neutron emissivity profile through the measurement of the neutron flux along several collimated channels. The present design of the RNC is based on collimating structures: an ex-port system viewing the plasma core and an in-port system composed by two detector cassettes viewing the upper and lower plasma edges. A design of the EPP1 in which the diagnostics are installed in three completely independent vertical drawers is under study. In this frame, space optimization and integration issues suggest two possible solutions for the layout of the in-port RNC cassettes: the first one in which both cassettes are located in a side drawer; the second one in which the two cassettes lie in the central drawer, on opposite sides of the ex-port RNC cut-out. This paper describes the work performed to assess the impact of the two different in-port system layouts on the capability of the RNC to measure the neutron emissivity profile by means of MCNP and diagnostic performance calculations. The results of the analysis provide guidelines for the integration of the RNC into the EPP1 showing that the proximity of the in-port cassettes to the ex-port cut-out strongly increases the amount of uncollimated and scattered neutrons at the detector positions, thus reducing the diagnostic measurement capability

  5. Matter Density Profile Shape Effects at DUNE

    Energy Technology Data Exchange (ETDEWEB)

    Kelly, Kevin J. [Northwestern U.; Parke, Stephen J. [Fermilab

    2018-02-19

    Quantum mechanical interactions between neutrinos and matter along the path of propagation, the Wolfenstein matter effect, are of particular importance for the upcoming long-baseline neutrino oscillation experiments, specifically the Deep Underground Neutrino Experiment (DUNE). Here, we explore specifically what about the matter density profile can be measured by DUNE, considering both the shape and normalization of the profile between the neutrinos' origin and detection. Additionally, we explore the capability of a perturbative method for calculating neutrino oscillation probabilities and whether this method is suitable for DUNE. We also briefly quantitatively explore the ability of DUNE to measure the Earth's matter density, and the impact of performing this measurement on measuring standard neutrino oscillation parameters.

  6. Residential Consumption Scheduling Based on Dynamic User Profiling

    Science.gov (United States)

    Mangiatordi, Federica; Pallotti, Emiliano; Del Vecchio, Paolo; Capodiferro, Licia

    Deployment of household appliances and of electric vehicles raises the electricity demand in the residential areas and the impact of the building's electrical power. The variations of electricity consumption across the day, may affect both the design of the electrical generation facilities and the electricity bill, mainly when a dynamic pricing is applied. This paper focuses on an energy management system able to control the day-ahead electricity demand in a residential area, taking into account both the variability of the energy production costs and the profiling of the users. The user's behavior is dynamically profiled on the basis of the tasks performed during the previous days and of the tasks foreseen for the current day. Depending on the size and on the flexibility in time of the user tasks, home inhabitants are grouped in, one over N, energy profiles, using a k-means algorithm. For a fixed energy generation cost, each energy profile is associated to a different hourly energy cost. The goal is to identify any bad user profile and to make it pay a highest bill. A bad profile example is when a user applies a lot of consumption tasks and low flexibility in task reallocation time. The proposed energy management system automatically schedules the tasks, solving a multi-objective optimization problem based on an MPSO strategy. The goals, when identifying bad users profiles, are to reduce the peak to average ratio in energy demand, and to minimize the energy costs, promoting virtuous behaviors.

  7. Influência de um programa de iniciação científica de graduação no perfil profissional dos médicos recém-formados The Influence of an undergraduate scientific initiation programme onn the professional profile of new physicians

    Directory of Open Access Journals (Sweden)

    Raphael Joaquim Teles Cyrillo

    2010-09-01

    Full Text Available Introdução: Este trabalho estuda a influência de um programa de iniciação científica (PIC no perfil profissional de médicos recém-formados numa universidade pública brasileira. Objectivos e métodos: Avaliamos cinquenta e dois novos médicos arrolados em dois grupos pareados por sexo, idade e coeficiente de rendimento académico, diferindo apenas na sua participação no PIC. Dados acerca da situação profissional e socioeconómica foram obtidos, incluindo a escolaridade dos pais; a renda familiar média antes, durante e depois da realização do curso médico; a situação profissional actual; as aprovações em concurso público e os títulos e graus obtidos após a graduação. Resultados: Diferenças significativas foram observadas apenas nas aprovações em concursos públicos (p = 0,0098 e na renda familiar após a graduação (p = 0,02, maiores ambas no grupo não PIC. Apenas um médico obteve o título de mestre após a graduação, embora muitos deles em ambos os grupos tenham obtidos títulos técnicos e publicado ou apresentado artigos médicos em congressos. Conclusões: Aparentemente, a participação num PIC implica menor renda familiar e menor número de aprovações em concursos públicos. Entretanto, isto pode reflectir apenas uma etapa passageira de um longo processo. Uma nova pesquisa, já em curso, virá esclarecer esta última questão, agora que mais tempo já decorreu desde as suas graduações.Introduction: This paper studies the influence of a Scientific Initiation Programme (SIP on the Professional profile of new doctors from a Brazilian university. Aim and methods: Evaluate fifty-two new doctors divided into two groups matched by sex, age and academic performance and differing only in participation in the SIP. Professional and socioeconomic data were collected, including schooling of parents; average income before, during and after the medical course; current Professional situation; results of exams for civil

  8. 77 FR 38191 - Approval and Promulgation of Implementation Plans; State of Mississippi; Regional Haze State...

    Science.gov (United States)

    2012-06-27

    ... SIP submittal followed the VISTAS modeling protocol and considered the contribution of total PM 10 and... revisions to the Mississippi State Implementation Plan (SIP) submitted by the State of Mississippi through.... Mississippi's SIP revisions address regional haze for the first implementation period. Specifically, these SIP...

  9. The relationship between multiple intelligence profiles and reading ...

    African Journals Online (AJOL)

    This study is thereby built on the premise that EFL readers' metacognitive awareness of reading strategies was also influenced by their multiple intelligence profiles. The purpose of this study is to explore the integrated impact of multiple intelligences and reading strategies on EFL learners' reading performance. This was an ...

  10. A response strategy predicts acquisition of schedule-induced polydipsia in rats.

    Science.gov (United States)

    Gregory, James Gardner; Hawken, Emily R; Banasikowski, Tomek J; Dumont, Eric C; Beninger, Richard J

    2015-08-03

    Schedule-induced polydipsia (SIP) is excessive, non-regulatory drinking. We aimed to identify phenotypic learning traits representative of neural circuitry that underlies SIP and hypothesized that rats that are response-learners will be more susceptible in developing compulsive water drinking. Using the Y-maze, the rats were characterized as either place- or response-learners. They were exposed to the SIP protocol for a period of 21days. Subsequent histological staining for FosB/ΔFosB examined neuronal activation associated with SIP in several brain regions. The rats with a preference for a response-learning strategy were more likely to develop SIP than the rats using a place-learning strategy. Furthermore amphetamine sensitization, observed to increase SIP, also shifted learning strategy to a response-learning strategy. No differences were observed in FosB/ΔFosB expression between SIP and non-SIP rats in the dorsolateral striatum (DLS) and CA1 region of the hippocampus. However, SIP rats had greater FosB/ΔFosB expression in prefrontal cortex regions. The rats that develop SIP have a preference for response-learning strategies and increased neuronal activation in frontal cortical regions associated with habit formation and compulsion. Copyright © 2015 Elsevier Inc. All rights reserved.

  11. Altered gene-expression profile in rat plasma and promoted body ...

    African Journals Online (AJOL)

    Altered gene-expression profile in rat plasma and promoted body and brain development ... The study was aimed to explore how the prenatal EE impacts affect the ... positively promote the body and nervous system development of offspring, ...

  12. 76 FR 66269 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2011-10-26

    ... enter SIP must send a protocol to FSIS informing the Agency about their plans for implementing SIP in... and packaged. The Salmonella initiative Program (SIP) offers incentives to meat and poultry slaughter establishments to control Salmonella in their operations. SIP benefits public health because it encourages...

  13. Country nuclear power profiles. 2000 ed

    International Nuclear Information System (INIS)

    2001-03-01

    The preparation of Country Nuclear Power Profiles was initiated within the framework of the IAEA programme on assessment and feedback of nuclear power plant performance. It responded to a need for a database and a technical document containing a description of the economic situation, the energy and the electricity sector and the primary organizations involved in nuclear power in IAEA Member States. In 1998, the first edition of the Country Nuclear Power Profiles was published focusing on the overall economic, energy and electricity situation in the country and on its nuclear power industrial structure and organizational framework. The compilation was made based on of 29 Member States with operating nuclear power plants by the end of 1995 and incorporated the 'Fact Sheets' on international, multilateral and bilateral agreements as collected by EXPO. In May 1999, an Advisory Group Meeting was organized with the purpose of updating the information in the Country Nuclear Power Profiles of each country, to reflect the new approaches and conditions of the national nuclear power programmes. The impact of the open electricity market, privatization and deregulation on the nuclear sector was an important aspect recommended by the experts to be taken in consideration. It was also recommended to periodically review the status and trends of nuclear industries in IAEA Member States and exchange information among experts of the lessons learned from the countries engaged in nuclear programmes, with a view to update the profiles at two year intervals. This second edition covers the changes in the new environment in the electricity as well as in the nuclear sector, be it that the situation differs from country to country. In general, the information is updated to 1999. For the preparation of this second edition, the IAEA received contributions from all 31 countries with operating power plants by the end of 1999, as well as Italy and the Islamic Republic of Iran. A database has been

  14. Gene Structures, Evolution, Classification and Expression Profiles of the Aquaporin Gene Family in Castor Bean (Ricinus communis L..

    Directory of Open Access Journals (Sweden)

    Zhi Zou

    Full Text Available Aquaporins (AQPs are a class of integral membrane proteins that facilitate the passive transport of water and other small solutes across biological membranes. Castor bean (Ricinus communis L., Euphobiaceae, an important non-edible oilseed crop, is widely cultivated for industrial, medicinal and cosmetic purposes. Its recently available genome provides an opportunity to analyze specific gene families. In this study, a total of 37 full-length AQP genes were identified from the castor bean genome, which were assigned to five subfamilies, including 10 plasma membrane intrinsic proteins (PIPs, 9 tonoplast intrinsic proteins (TIPs, 8 NOD26-like intrinsic proteins (NIPs, 6 X intrinsic proteins (XIPs and 4 small basic intrinsic proteins (SIPs on the basis of sequence similarities. Functional prediction based on the analysis of the aromatic/arginine (ar/R selectivity filter, Froger's positions and specificity-determining positions (SDPs showed a remarkable difference in substrate specificity among subfamilies. Homology analysis supported the expression of all 37 RcAQP genes in at least one of examined tissues, e.g., root, leaf, flower, seed and endosperm. Furthermore, global expression profiles with deep transcriptome sequencing data revealed diverse expression patterns among various tissues. The current study presents the first genome-wide analysis of the AQP gene family in castor bean. Results obtained from this study provide valuable information for future functional analysis and utilization.

  15. Chip-carrier thermal barrier and its impact on lateral thermal lens profile and beam parameter product in high power broad area lasers

    Science.gov (United States)

    Rieprich, J.; Winterfeldt, M.; Kernke, R.; Tomm, J. W.; Crump, P.

    2018-03-01

    High power broad area diode lasers with high optical power density in a small focus spot are in strong commercial demand. For this purpose, the beam quality, quantified via the beam parameter product (BPP), has to be improved. Previous studies have shown that the BPP is strongly affected by current-induced heating and the associated thermal lens formed within the laser stripe. However, the chip structure and module-assembly related factors that regulate the size and the shape of the thermal lens are not well known. An experimental infrared thermographic technique is used to quantify the thermal lens profile in diode lasers operating at an emission wavelength of 910 nm, and the results are compared with finite element method simulations. The analysis indicates that the measured thermal profiles can best be explained when a thermal barrier is introduced between the chip and the carrier, which is shown to have a substantial impact on the BPP and the thermal resistance. Comparable results are observed in further measurements of samples from multiple vendors, and the barrier is only observed for junction-down (p-down) mounting, consistent with the barrier being associated with the GaAs-metal transition.

  16. Modelling baryonic effects on galaxy cluster mass profiles

    Science.gov (United States)

    Shirasaki, Masato; Lau, Erwin T.; Nagai, Daisuke

    2018-06-01

    Gravitational lensing is a powerful probe of the mass distribution of galaxy clusters and cosmology. However, accurate measurements of the cluster mass profiles are limited by uncertainties in cluster astrophysics. In this work, we present a physically motivated model of baryonic effects on the cluster mass profiles, which self-consistently takes into account the impact of baryons on the concentration as well as mass accretion histories of galaxy clusters. We calibrate this model using the Omega500 hydrodynamical cosmological simulations of galaxy clusters with varying baryonic physics. Our model will enable us to simultaneously constrain cluster mass, concentration, and cosmological parameters using stacked weak lensing measurements from upcoming optical cluster surveys.

  17. Modelling Baryonic Effects on Galaxy Cluster Mass Profiles

    Science.gov (United States)

    Shirasaki, Masato; Lau, Erwin T.; Nagai, Daisuke

    2018-03-01

    Gravitational lensing is a powerful probe of the mass distribution of galaxy clusters and cosmology. However, accurate measurements of the cluster mass profiles are limited by uncertainties in cluster astrophysics. In this work, we present a physically motivated model of baryonic effects on the cluster mass profiles, which self-consistently takes into account the impact of baryons on the concentration as well as mass accretion histories of galaxy clusters. We calibrate this model using the Omega500 hydrodynamical cosmological simulations of galaxy clusters with varying baryonic physics. Our model will enable us to simultaneously constrain cluster mass, concentration, and cosmological parameters using stacked weak lensing measurements from upcoming optical cluster surveys.

  18. Interpretive reliability of two common MMPI-2 profiles

    Directory of Open Access Journals (Sweden)

    Mark A. Deskovitz

    2016-12-01

    Full Text Available Users of multi-scale tests like the MMPI-2 tend not to interpret scales one at a time in a way that would correspond to standard scale-level reliability information. Instead, clinicians integrate inferences from a multitude of scales simultaneously, producing a descriptive narrative that is thought to characterize the examinee. This study was an attempt to measure the reliability of such integrated interpretations using a q-sort research methodology. Participants were 20 MMPI-2 users who responded to E-mail solicitations on professional listservs and in personal emails. Each participant interpreted one of two common MMPI-2 profiles using a q-set of 100 statements designed for MMPI-2 interpretation. To measure the “interpretive reliability” of the MMPI-2 profile interpretations, q-sort descriptions were intercorrelated. Mean pairwise interpretive reliability was .39, lower than expected, and there was no significant difference in reliability between profiles. There was also not a significant difference between within-profile and cross-profile correlations. Q-set item analysis was conducted to determine which individual statements had the most impact on interpretive reliability. Although sampling in this study was limited, implications for the field reliability of MMPI-2 interpretation are sobering.

  19. Behavior of the bottomside electron density profile over Pruhonice

    Czech Academy of Sciences Publication Activity Database

    Mosert, M.; Burešová, Dalia; Ezquer, R.; Mansilla, G.

    2004-01-01

    Roč. 34, č. 9 (2004), s. 1982-1989 ISSN 0273-1177 R&D Projects: GA AV ČR IAA3042102 Institutional research plan: CEZ:AV0Z3042911 Keywords : Electron density profiles * Variability Subject RIV: DG - Athmosphere Sciences, Meteorology Impact factor: 0.548, year: 2004

  20. 76 FR 51925 - Approval and Promulgation of Air Quality Implementation Plans; Maryland; Adhesives and Sealants Rule

    Science.gov (United States)

    2011-08-19

    ... http://www.regulations.gov Web site is an ``anonymous access'' system, which means EPA will not know..., the Maryland Department of the Environment (MDE) submitted revisions to its SIP (Maryland SIP 08-02....11.35). On May 28, 2009, MDE submitted another revision to its SIP (Maryland SIP 09-01) amending...

  1. Semi-infinite programming recent advances

    CERN Document Server

    López, Marco

    2001-01-01

    Semi-infinite programming (SIP) deals with optimization problems in which either the number of decision variables or the number of constraints is finite This book presents the state of the art in SIP in a suggestive way, bringing the powerful SIP tools close to the potential users in different scientific and technological fields The volume is divided into four parts Part I reviews the first decade of SIP (1962-1972) Part II analyses convex and generalised SIP, conic linear programming, and disjunctive programming New numerical methods for linear, convex, and continuously differentiable SIP problems are proposed in Part III Finally, Part IV provides an overview of the applications of SIP to probability, statistics, experimental design, robotics, optimization under uncertainty, production games, and separation problems Audience This book is an indispensable reference and source for advanced students and researchers in applied mathematics and engineering

  2. Prognostic Impact of Array-based Genomic Profiles in Esophageal Squamous Cell Cancer

    International Nuclear Information System (INIS)

    Carneiro, Ana; Isinger, Anna; Karlsson, Anna; Johansson, Jan; Jönsson, Göran; Bendahl, Pär-Ola; Falkenback, Dan; Halvarsson, Britta; Nilbert, Mef

    2008-01-01

    Esophageal squamous cell carcinoma (ESCC) is a genetically complex tumor type and a major cause of cancer related mortality. Although distinct genetic alterations have been linked to ESCC development and prognosis, the genetic alterations have not gained clinical applicability. We applied array-based comparative genomic hybridization (aCGH) to obtain a whole genome copy number profile relevant for identifying deranged pathways and clinically applicable markers. A 32 k aCGH platform was used for high resolution mapping of copy number changes in 30 stage I-IV ESCC. Potential interdependent alterations and deranged pathways were identified and copy number changes were correlated to stage, differentiation and survival. Copy number alterations affected median 19% of the genome and included recurrent gains of chromosome regions 5p, 7p, 7q, 8q, 10q, 11q, 12p, 14q, 16p, 17p, 19p, 19q, and 20q and losses of 3p, 5q, 8p, 9p and 11q. High-level amplifications were observed in 30 regions and recurrently involved 7p11 (EGFR), 11q13 (MYEOV, CCND1, FGF4, FGF3, PPFIA, FAD, TMEM16A, CTTS and SHANK2) and 11q22 (PDFG). Gain of 7p22.3 predicted nodal metastases and gains of 1p36.32 and 19p13.3 independently predicted poor survival in multivariate analysis. aCGH profiling verified genetic complexity in ESCC and herein identified imbalances of multiple central tumorigenic pathways. Distinct gains correlate with clinicopathological variables and independently predict survival, suggesting clinical applicability of genomic profiling in ESCC

  3. Effect of recombinant human insulin-like growth factor-I on progression of ALS. A placebo-controlled study. The North America ALS/IGF-I Study Group.

    Science.gov (United States)

    Lai, E C; Felice, K J; Festoff, B W; Gawel, M J; Gelinas, D F; Kratz, R; Murphy, M F; Natter, H M; Norris, F H; Rudnicki, S A

    1997-12-01

    The objective of this study was to investigate the safety and efficacy of recombinant human insulinlike growth factor-I (rhIGF-I) in the treatment of sporadic ALS. A double-blind, placebo-controlled, randomized study of 266 patients was conducted at eight centers in North America. Placebo or rhIGF-I (0.05 mg/kg/day or 0.10 mg/kg/day) was administered for 9 months. The primary outcome measure was disease symptom progression, assessed by the rate of change (per patient slope) in the Appel ALS rating scale total score. The Sickness Impact Profile (SIP), a patient-perceived, health-related quality of life assessment, was a secondary outcome variable. Progression of functional impairment in patients receiving high-dose (0.10 mg/kg/day) rhIGF-I was 26% slower than in patients receiving placebo (p = 0.01). The high-dose treatment group was less likely to terminate the study due to protocol-defined markers of disease symptom progression, and members in this group exhibited a slower decline in quality of life, as assessed by the SIP. Patients receiving 0.05 mg/kg/day of rhIGF-I exhibited trends similar to those associated with high-dose treatment, suggesting a dose-dependent response. The incidence of clinically significant adverse experiences was comparable among the three treatment groups. Recombinant human insulin-like growth factor-I slowed the progression of functional impairment and the decline in health-related quality of life in patients with ALS with no medically important adverse effects.

  4. Protection against Foot-and-Mouth Disease Virus in Guinea Pigs via Oral Administration of Recombinant Lactobacillus plantarum Expressing VP1.

    Directory of Open Access Journals (Sweden)

    Miao Wang

    Full Text Available Mucosal vaccination is an effective strategy for generating antigen-specific immune responses against mucosal infections of foot-and-mouth disease virus (FMDV. In this study, Lactobacillus plantarum strains NC8 and WCFS1 were used as oral delivery vehicles containing a pSIP411-VP1 recombinant plasmid to initiate mucosal and systemic immune responses in guinea pigs. Guinea pigs were orally vaccinated (three doses with NC8-pSIP411, NC8-pSIP411-VP1, WCFS1-pSIP411, WCFS1-pSIP411-VP1 or milk. Animals immunized with NC8-pSIP411-VP1 and WCFS1-pSIP411-VP1 developed high levels of antigen-specific serum IgG, IgA, IgM, mucosal secretory IgA (sIgA and neutralizing antibodies, and revealed stronger cell-mediated immune responses and enhanced protection against FMDV challenge compared with control groups. The recombinant pSIP411-VP1 effectively improved immunoprotection against FMDV in guinea pigs.

  5. Analysis of the profile characteristics of corn and soybeans using field reflectance data

    Science.gov (United States)

    Crist, E. P.

    1982-01-01

    The typical patterns of spectral development (profiles) for corn and soybeans are presented, based on field-collected reflectance data transformed to correspond to LANDSAT-MSS Tasseled Cap coordinates. Reasonable variations in field conditions and cultural practices are shown to significantly influence profile features. The separability of the two crops is determined to be primarily related to the maximum value of the reflectance equivalent of Greenness, and to the plateau effect seen in corn Greenness profiles. The impact of changes in conditions on separability is described. In addition, association is made between profile features and stages of development for corn and soybeans. Corn is shown to peak at a stage well before tasseling or maximum LAI, while the characteristics of the soybean profile are shown to be unrelated to any particular stage of development.

  6. Rhizosphere Protists Change Metabolite Profiles in Zea mays

    Directory of Open Access Journals (Sweden)

    Anke Kuppardt

    2018-05-01

    Full Text Available Plant growth and productivity depend on the interactions of the plant with the associated rhizosphere microbes. Rhizosphere protists play a significant role in this respect: considerable efforts have been made in the past to reveal the impact of protist-bacteria interactions on the remobilization of essential nutrients for plant uptake, or the grazing induced changes on plant-growth promoting bacteria and the root-architecture. However, the metabolic responses of plants to the presence of protists or to protist-bacteria interactions in the rhizosphere have not yet been analyzed. Here we studied in controlled laboratory experiments the impact of bacterivorous protists in the rhizosphere on maize plant growth parameters and the bacterial community composition. Beyond that we investigated the induction of plant biochemical responses by separately analyzing above- and below-ground metabolite profiles of maize plants incubated either with a soil bacterial inoculum or with a mixture of soil bacteria and bacterivorous protists. Significantly distinct leaf and root metabolite profiles were obtained from plants which grew in the presence of protists. These profiles showed decreased levels of a considerable number of metabolites typical for the plant stress reaction, such as polyols, a number of carbohydrates and metabolites connected to phenolic metabolism. We assume that this decrease in plant stress is connected to the grazing induced shifts in rhizosphere bacterial communities as shown by distinct T-RFLP community profiles. Protist grazing had a clear effect on the overall bacterial community composition, richness and evenness in our microcosms. Given the competition of plant resource allocation to either defense or growth, we propose that a reduction in plant stress levels caused directly or indirectly by protists may be an additional reason for corresponding positive effects on plant growth.

  7. Rhizosphere Protists Change Metabolite Profiles in Zea mays.

    Science.gov (United States)

    Kuppardt, Anke; Fester, Thomas; Härtig, Claus; Chatzinotas, Antonis

    2018-01-01

    Plant growth and productivity depend on the interactions of the plant with the associated rhizosphere microbes. Rhizosphere protists play a significant role in this respect: considerable efforts have been made in the past to reveal the impact of protist-bacteria interactions on the remobilization of essential nutrients for plant uptake, or the grazing induced changes on plant-growth promoting bacteria and the root-architecture. However, the metabolic responses of plants to the presence of protists or to protist-bacteria interactions in the rhizosphere have not yet been analyzed. Here we studied in controlled laboratory experiments the impact of bacterivorous protists in the rhizosphere on maize plant growth parameters and the bacterial community composition. Beyond that we investigated the induction of plant biochemical responses by separately analyzing above- and below-ground metabolite profiles of maize plants incubated either with a soil bacterial inoculum or with a mixture of soil bacteria and bacterivorous protists. Significantly distinct leaf and root metabolite profiles were obtained from plants which grew in the presence of protists. These profiles showed decreased levels of a considerable number of metabolites typical for the plant stress reaction, such as polyols, a number of carbohydrates and metabolites connected to phenolic metabolism. We assume that this decrease in plant stress is connected to the grazing induced shifts in rhizosphere bacterial communities as shown by distinct T-RFLP community profiles. Protist grazing had a clear effect on the overall bacterial community composition, richness and evenness in our microcosms. Given the competition of plant resource allocation to either defense or growth, we propose that a reduction in plant stress levels caused directly or indirectly by protists may be an additional reason for corresponding positive effects on plant growth.

  8. Aggression in Children with Conduct Problems and Callous-Unemotional Traits: Social Information Processing and Response to Peer Provocation.

    Science.gov (United States)

    Helseth, Sarah A; Waschbusch, Daniel A; King, Sara; Willoughby, Michael T

    2015-11-01

    Callous/unemotional traits (CU) moderate children's conduct problems (CP) in numerous domains, including social functioning. The present study examined whether CU traits also moderate the aggressiveness of children's social information processing (SIP) and responses to varying intensities of peer provocation. Sixty elementary school-age children (46 males) were grouped into those without CP or CU (controls, n = 32), those with CP but not CU (CP-only; n = 14), and those with both CP and CU (CPCU, n = 14). Participants completed a task that measured two aspects of SIP (response generation and hostile attribution bias) and a computerized reaction time task (CRTT) that measured behavior, affect, and communication before and after provocation under instrumental and hostile aggressive conditions. Children with CPCU generated more aggressive responses than controls on measures of SIP. On the CRTT, all children exhibited reactive aggression following high provocation, but only children with CPCU exhibited proactive aggression, and reactive aggression following low provocation; no differences in affect were found. In a series of exploratory analyses, CPCU children communicated antisocially, while CP-only communicated prosocially. Finally, children with CPCU did not seem to hold a grudge following the final instance of provocation, instead gradually returning to baseline like their non-CU peers. These distinct social cognitive and behavioral profiles hint at different etiologies of CP and CPCU, underscoring the variability of aggression in these populations.

  9. Pregnancy Outcomes in Women with Preeclampsia Superimposed on Chronic Hypertension with and without Severe Features.

    Science.gov (United States)

    Moussa, Hind N; Leon, Mateo G; Marti, Ana; Chediak, Alissar; Pedroza, Claudia; Blackwell, Sean C; Sibai, Baha M

    2017-03-01

    Objective  The American Congress of Obstetricians and Gynecologists (ACOG) task force on hypertension in pregnancy introduced a new definition of superimposed preeclampsia (SIP) adding severe features (SF) as new criteria to define severe disease. They also recommended that those with SIP be delivered ≥ 37 weeks, whereas those with SF be delivered ≤ 34 weeks. Our aim was to investigate the validity of this new definition by comparing adverse pregnancy outcomes in SIP with (SIP-SF) and without SF (SIP). Study Design  Women with chronic hypertension (CHTN) enrolled in a multicenter trial were studied. SIP was reclassified according to the new definition to SIP and SIP-SF (persistent systolic blood pressure [BP] > 160 or diastolic BP > 110, platelets  70, creatinine > 1.1, or persistent central nervous system/abdominal symptoms). Composite adverse outcomes including rates of indicated preterm birth, abruptio placentae, postpartum hemorrhage, and maternal death were compared by chi-square. Adjustment was done with a multivariate logistic-regression analysis and all statistical tests were two-sided. Results  A total of 216 women (28%) out of 774 with CHTN developed SIP, 87 (11%) had SIP-SF, and 129 (17%) didn't have SF. Baseline characteristics including maternal age, baseline BP, and assignment to low-dose aspirin were similar between groups. Using univariate analysis, the composite adverse outcome was higher among the SIP-SF group ( p  = 0.04), as well as indicated preterm birth ( p  = 0.02), cesarean section ( p  = 0.02), and SGA ( p  = 0.02). After adjustment, composite adverse outcomes were not significantly different between groups. The rate of SGA, however, was higher among SIP-SF (adjusted odds ratio: 3.12, p  = 0.02). Conclusion  The rate of SIP-SF in this study was 11% of all women with CHTN. Surprisingly, pregnancy outcomes were not significantly different in those with and without SF. We suggest a

  10. Activity-Based Protein Profiling of Rhomboid Proteases in Liposomes

    Czech Academy of Sciences Publication Activity Database

    Wolf, E. V.; Seybold, M.; Hadravová, Romana; Stříšovský, Kvido; Verhelst, S. H. L.

    2015-01-01

    Roč. 16, č. 11 (2015), s. 1616-1621 ISSN 1439-4227 R&D Projects: GA MŠk(CZ) LK11206; GA MŠk LO1302 Institutional support: RVO:61388963 Keywords : activity-based protein profiling * chemical probes * inhibitors * intramembrane proteases * liposomes Subject RIV: CE - Biochemistry Impact factor: 2.850, year: 2015

  11. Health profiles in people with intellectual developmental disorders

    Directory of Open Access Journals (Sweden)

    Anabel Folch-Mas

    2017-07-01

    Full Text Available Objective. To better understand the health profiles of people with intellectual disability (ID, focusing on the variables that are associated with a poorer health status. Materials and methods. Data were collected from the Survey on Disability, Personal Autonomy and Dependency (EDAD 2008 of the Spanish National Statistics Institute (INE. The health data of 2 840 subjects with IDD were analyzed in order to verify the impact of different variables on their health profiles. Results. People with severe and profound levels of IDD presented a higher number of medical diagnoses.At residence centers there was a larger proportion of individuals with a higher prevalence of chronic diseases and more severe conditions; age also was an important factor. Conclusion. The health profiles of individuals with IDD differ depending on the severity level of their IDD and their degree of institutionalization. Further research is needed to provide better health care for people with IDD.

  12. Dynamic temperature and humidity environmental profiles: impact for future emergency and disaster preparedness and response.

    Science.gov (United States)

    Ferguson, William J; Louie, Richard F; Tang, Chloe S; Paw U, Kyaw Tha; Kost, Gerald J

    2014-02-01

    During disasters and complex emergencies, environmental conditions can adversely affect the performance of point-of-care (POC) testing. Knowledge of these conditions can help device developers and operators understand the significance of temperature and humidity limits necessary for use of POC devices. First responders will benefit from improved performance for on-site decision making. To create dynamic temperature and humidity profiles that can be used to assess the environmental robustness of POC devices, reagents, and other resources (eg, drugs), and thereby, to improve preparedness. Surface temperature and humidity data from the National Climatic Data Center (Asheville, North Carolina USA) was obtained, median hourly temperature and humidity were calculated, and then mathematically stretched profiles were created to include extreme highs and lows. Profiles were created for: (1) Banda Aceh, Indonesia at the time of the 2004 Tsunami; (2) New Orleans, Louisiana USA just before and after Hurricane Katrina made landfall in 2005; (3) Springfield, Massachusetts USA for an ambulance call during the month of January 2009; (4) Port-au-Prince, Haiti following the 2010 earthquake; (5) Sendai, Japan for the March 2011 earthquake and tsunami with comparison to the colder month of January 2011; (6) New York, New York USA after Hurricane Sandy made landfall in 2012; and (7) a 24-hour rescue from Hawaii USA to the Marshall Islands. Profiles were validated by randomly selecting 10 days and determining if (1) temperature and humidity points fell inside and (2) daily variations were encompassed. Mean kinetic temperatures (MKT) were also assessed for each profile. Profiles accurately modeled conditions during emergency and disaster events and enclosed 100% of maximum and minimum temperature and humidity points. Daily variations also were represented well with 88.6% (62/70) of temperature readings and 71.1% (54/70) of relative humidity readings falling within diurnal patterns. Days

  13. Health impact assessment of air pollution using a dynamic exposure profile: Implications for exposure and health impact estimates

    International Nuclear Information System (INIS)

    Dhondt, Stijn; Beckx, Carolien; Degraeuwe, Bart; Lefebvre, Wouter; Kochan, Bruno; Bellemans, Tom; Int Panis, Luc; Macharis, Cathy; Putman, Koen

    2012-01-01

    In both ambient air pollution epidemiology and health impact assessment an accurate assessment of the population exposure is crucial. Although considerable advances have been made in assessing human exposure outdoors, the assessments often do not consider the impact of individual travel behavior on such exposures. Population-based exposures to NO 2 and O 3 using only home addresses were compared with models that integrate all time-activity patterns—including time in commute—for Flanders and Brussels. The exposure estimates were used to estimate the air pollution impact on years of life lost due to respiratory mortality. Health impact of NO 2 using an exposure that integrates time-activity information was on average 1.2% higher than when assuming that people are always at their home address. For ozone the overall estimated health impact was 0.8% lower. Local differences could be much larger, with estimates that differ up to 12% from the exposure using residential addresses only. Depending on age and gender, deviations from the population average were seen. Our results showed modest differences on a regional level. At the local level, however, time-activity patterns indicated larger differences in exposure and health impact estimates, mainly for people living in more rural areas. These results suggest that for local analyses the dynamic approach can contribute to an improved assessment of the health impact of various types of pollution and to the understanding of exposure differences between population groups. - Highlights: ► Exposure to ambient air pollution was assessed integrating population mobility. ► This dynamic exposure was integrated into a health impact assessment. ► Differences between the dynamic and residential exposure were quantified. ► Modest differences in health impact were found at a regional level. ► At municipal level larger differences were found, influenced by gender and age.

  14. Participation restrictions in ambulatory amyotrophic lateral sclerosis patients: Physical and psychological factors.

    Science.gov (United States)

    Van Groenestijn, Annerieke C; Schröder, Carin D; Kruitwagen-Van Reenen, Esther T; Van Den Berg, Leonard H; Visser-Meily, Johanna M A

    2017-11-01

    The aim of this study was to assess the prevalence of participation restrictions in ambulatory patients with amyotrophic lateral sclerosis (ALS) and to identify physical and psychological contributory factors. In this cross-sectional study, self-reported participation restrictions of 72 ambulatory ALS patients were assessed using the social health status dimension (SIPSOC) of the Sickness Impact Profile (SIP-68). Associations between SIPSOC and physical functioning, psychological factors, and demographic factors were analyzed using hierarchical regression analyses. Ninety-two percent of the patients reported participation restrictions; 54.9% could be explained by physical functioning; psychological factors accounted for 8.1% of the variance. Lung capacity, functional mobility, fatigue, and helplessness were independently associated with participation restrictions. Ambulatory ALS patients have participation restrictions, which may be influenced if early ALS care is directed toward lung capacity, functional mobility, fatigue, and feelings of helplessness. Muscle Nerve 56: 912-918, 2017. © 2017 Wiley Periodicals, Inc.

  15. Analysis of electric vehicle driver recharging demand profiles and subsequent impacts on the carbon content of electric vehicle trips

    International Nuclear Information System (INIS)

    Robinson, A.P.; Blythe, P.T.; Bell, M.C.; Hübner, Y.; Hill, G.A.

    2013-01-01

    This paper quantifies the recharging behaviour of a sample of electric vehicle (EV) drivers and evaluates the impact of current policy in the north east of England on EV driver recharging demand profiles. An analysis of 31,765 EV trips and 7704 EV recharging events, constituting 23,805 h of recharging, were recorded from in-vehicle loggers as part of the Switch EV trials is presented. Altogether 12 private users, 21 organisation individuals and 32 organisation pool vehicles were tracked over two successive six month trial periods. It was found that recharging profiles varied between the different user types and locations. Private users peak demand was in the evening at home recharging points. Organisation individual vehicles were recharged primarily upon arrival at work. Organisation pool users recharged at work and public recharging points throughout the working day. It is recommended that pay-as-you-go recharging be implemented at all public recharging locations, and smart meters be used to delay recharging at home and work locations until after 23:00 h to reduce peak demand on local power grids and reduce carbon emissions associated with EV recharging. - Highlights: • Study of EV driver recharging habits in the north east of England. • 7704 electric vehicle recharging events, comprising 23,805 h were collected. • There was minimal recharging during off- peak hours. • Free parking and electricity at point of use encouraged daytime recharging. • Need for financial incentives and smart solutions to better manage recharging demand peaks

  16. Molecular depth profiling of trehalose using a C{sub 60} cluster ion beam

    Energy Technology Data Exchange (ETDEWEB)

    Wucher, Andreas [Department of Physics, University of Duisburg-Essen, D-47048 Duisburg (Germany)], E-mail: andreas.wucher@uni-due.de; Cheng Juan; Winograd, Nicholas [Department of Chemistry, Pennsylvania State University, University Park, PA 16802 (United States)

    2008-12-15

    Molecular depth profiling of organic overlayers was performed using a mass selected fullerene ion beam in conjunction with time-of-flight (TOF-SIMS) mass spectrometry. The characteristics of depth profiles acquired on a 300-nm trehalose film on Si were studied as a function of the impact kinetic energy and charge state of the C{sub 60} projectile ions. We find that the achieved depth resolution depends only weakly upon energy.

  17. Modeling and Experimental Tests of a Mechatronic Device to Measure Road Profiles Considering Impact Dynamics

    DEFF Research Database (Denmark)

    Souza, A.; Santos, Ilmar

    2002-01-01

    of a vehicle and to test its components in laboratory. In this framework a mechanism to measure road profiles is designed and presented. Such a mechanism is composed of two rolling wheels and two long beams attached to the vehicles by means of four Kardan joints. The wheels are kept in contact to the ground...... to highlight that the aim of this device is to independently measure two road profiles, without the influence of the vehicle dynamics where the mechanism is attached. Before the mechatronic mechanism is attached to a real vehicle, its dynamic behavior must be known. A theoretical analysis of the mechanism...... predicts well the mechanism movements. However it was also experimentally observed that the contact between the wheels and the road profile is not permanent. To analyze the non-contact between the wheels and the road, the Newton-Euler´s Method is used to calculate forces and moments of reactions between...

  18. Stable isotope phenotyping via cluster analysis of NanoSIMS data as a method for characterizing distinct microbial ecophysiologies and sulfur-cycling in the environment

    Directory of Open Access Journals (Sweden)

    Katherine S Dawson

    2016-05-01

    Full Text Available Stable isotope probing (SIP is a valuable tool for gaining insights into ecophysiology and biogeochemical cycling of environmental microbial communities by tracking isotopically labeled compounds into cellular macromolecules as well as into byproducts of respiration. SIP, in conjunction with nanoscale secondary ion mass spectrometry (NanoSIMS, allows for the visualization of isotope incorporation at the single cell level. In this manner, both active cells within a diverse population as well as heterogeneity in metabolism within a homogeneous population can be observed. The ecophysiological implications of these single cell stable isotope measurements are often limited to the taxonomic resolution of paired fluorescence in situ hybridization (FISH microscopy. Here we introduce a taxonomy-independent method using multi-isotope SIP and NanoSIMS for identifying and grouping phenotypically similar microbial cells by their chemical and isotopic fingerprint. This method was applied to SIP experiments in a sulfur-cycling biofilm collected from sulfidic intertidal vents amended with 13C-acetate, 15N-ammonium, and 33S-sulfate. Using a cluster analysis technique based on fuzzy c-means to group cells according to their isotope (13C/12C, 15N/14N, and 33S/32S and elemental ratio (C/CN and S/CN profiles, our analysis partitioned ~2200 cellular regions of interest (ROIs into 5 distinct groups. These isotope phenotype groupings are reflective of the variation in labeled substrate uptake by cells in a multispecies metabolic network dominated by Gamma- and Deltaproteobacteria. Populations independently grouped by isotope phenotype were subsequently compared with paired FISH data, demonstrating a single coherent deltaproteobacterial cluster and multiple gammaproteobacterial groups, highlighting the distinct ecophysiologies of spatially-associated microbes within the sulfur-cycling biofilm from White Point Beach, CA.

  19. Gene expression profiling in circulating cells (ctcs) of breast carcinoma patients

    Czech Academy of Sciences Publication Activity Database

    Kološtová, K.; Pinterová, D.; Tesařová, P.; Mikulová, V.; Kubecová, M.; Brychta, M.; Rusňáková, Vendula; Kasimir-Bauer, S.; Kubista, Mikael

    2010-01-01

    Roč. 21, suppl. 4 (2010), s. 49-59 ISSN 0923-7534 Institutional research plan: CEZ:AV0Z50520701 Keywords : Circulating tumor cells * Breast cancer * Gene expression profiling Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 6.452, year: 2010

  20. Health impact assessment of air pollution using a dynamic exposure profile: Implications for exposure and health impact estimates

    Energy Technology Data Exchange (ETDEWEB)

    Dhondt, Stijn, E-mail: stijn.dhondt@vub.ac.be [Department of Medical Sociology and Health Sciences, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090, Brussels (Belgium); Beckx, Carolien, E-mail: Carolien.Beckx@vito.be [Flemish Institute for Technological Research (VITO), Boeretang 200, 2400 Mol (Belgium); Degraeuwe, Bart, E-mail: Bart.Degraeuwe@vito.be [Flemish Institute for Technological Research (VITO), Boeretang 200, 2400 Mol (Belgium); Lefebvre, Wouter, E-mail: Wouter.Lefebvre@vito.be [Flemish Institute for Technological Research (VITO), Boeretang 200, 2400 Mol (Belgium); Kochan, Bruno, E-mail: Bruno.Kochan@uhasselt.be [Transportation Research Institute, Hasselt University, Wetenschapspark 5 bus 6, 3590 Diepenbeek (Belgium); Bellemans, Tom, E-mail: Tom.Bellemans@uhasselt.be [Transportation Research Institute, Hasselt University, Wetenschapspark 5 bus 6, 3590 Diepenbeek (Belgium); Int Panis, Luc, E-mail: Luc.intpanis@vito.be [Flemish Institute for Technological Research (VITO), Boeretang 200, 2400 Mol (Belgium); Transportation Research Institute, Hasselt University, Wetenschapspark 5 bus 6, 3590 Diepenbeek (Belgium); Macharis, Cathy, E-mail: cjmachar@vub.ac.be [Department MOSI-Transport and Logistics, Vrije Universiteit Brussel, Pleinlaan 2, B-1050, Brussels (Belgium); Putman, Koen, E-mail: kputman@vub.ac.be [Department of Medical Sociology and Health Sciences, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090, Brussels (Belgium); Interuniversity Centre for Health Economics Research (I-CHER), Vrije Universiteit Brussel, Brussels (Belgium)

    2012-09-15

    In both ambient air pollution epidemiology and health impact assessment an accurate assessment of the population exposure is crucial. Although considerable advances have been made in assessing human exposure outdoors, the assessments often do not consider the impact of individual travel behavior on such exposures. Population-based exposures to NO{sub 2} and O{sub 3} using only home addresses were compared with models that integrate all time-activity patterns-including time in commute-for Flanders and Brussels. The exposure estimates were used to estimate the air pollution impact on years of life lost due to respiratory mortality. Health impact of NO{sub 2} using an exposure that integrates time-activity information was on average 1.2% higher than when assuming that people are always at their home address. For ozone the overall estimated health impact was 0.8% lower. Local differences could be much larger, with estimates that differ up to 12% from the exposure using residential addresses only. Depending on age and gender, deviations from the population average were seen. Our results showed modest differences on a regional level. At the local level, however, time-activity patterns indicated larger differences in exposure and health impact estimates, mainly for people living in more rural areas. These results suggest that for local analyses the dynamic approach can contribute to an improved assessment of the health impact of various types of pollution and to the understanding of exposure differences between population groups. - Highlights: Black-Right-Pointing-Pointer Exposure to ambient air pollution was assessed integrating population mobility. Black-Right-Pointing-Pointer This dynamic exposure was integrated into a health impact assessment. Black-Right-Pointing-Pointer Differences between the dynamic and residential exposure were quantified. Black-Right-Pointing-Pointer Modest differences in health impact were found at a regional level. Black

  1. Characteristics of aerosol vertical profiles in Tsukuba, Japan, and their impacts on the evolution of the atmospheric boundary layer

    Science.gov (United States)

    Kudo, Rei; Aoyagi, Toshinori; Nishizawa, Tomoaki

    2018-05-01

    Vertical profiles of the aerosol physical and optical properties, with a focus on seasonal means and on transport events, were investigated in Tsukuba, Japan, by a synergistic remote sensing method that uses lidar and sky radiometer data. The retrieved aerosol vertical profiles of the springtime mean and five transport events were input to our developed one-dimensional atmospheric model, and the impacts of the aerosol vertical profiles on the evolution of the atmospheric boundary layer (ABL) were studied by numerical sensitivity experiments. The characteristics of the aerosol vertical profiles in Tsukuba are as follows: (1) the retrieval results in the spring showed that aerosol optical thickness at 532 nm in the free atmosphere (FA) was 0.13, greater than 0.08 in the ABL owing to the frequent occurrence of transported aerosols in the FA. In other seasons, optical thickness in the FA was almost the same as that in the ABL. (2) The aerosol optical and physical properties in the ABL showed a dependency on the extinction coefficient. With an increase in the extinction coefficient from 0.00 to 0.24 km-1, the Ångström exponent increased from 0.0 to 2.0, the single-scattering albedo increased from 0.87 to 0.99, and the asymmetry factor decreased from 0.75 to 0.50. (3) The large variability in the physical and optical properties of aerosols in the FA were attributed to transport events, during which the transported aerosols consisted of varying amounts of dust and smoke particles depending on where they originated (China, Mongolia, or Russia). The results of the numerical sensitivity experiments using the aerosol vertical profiles of the springtime mean and five transport events in the FA are as follows: (1) numerical sensitivity experiments based on simulations conducted with and without aerosols showed that aerosols caused the net downward radiation and the sensible and latent heat fluxes at the surface to decrease. The decrease in temperature in the ABL (-0.2 to -0

  2. Social information processing skills in adolescents with traumatic brain injury: Relationship with social competence and behavior problems.

    Science.gov (United States)

    Walz, Nicolay Chertkoff; Yeates, Keith Owen; Wade, Shari L; Mark, Erin

    2009-01-01

    To examine social information processing (SIP) skills, behavior problems, and social competence following adolescent TBI and to determine whether SIP skills were predictive of behavior problems and social competence. Cross-sectional analyses of adolescents with TBI recruited and enrolled in a behavioral treatment study currently in progress. Two tertiary care children's hospitals with Level 1 trauma centers. Adolescents aged 11 to 18 years with severe TBI (n=19) and moderate TBI (n=24) who were injured up to 24 months prior to recruitment. TBI severity, race, maternal education, and age at testing. a measure of SIP skills, Child Behavior Checklist (CBCL), Youth Self Report (YSR), and Home and Community Social Behavior Scale (HCSBS). The severe TBI group did not obtain significantly lower scores on the SIP measures than the moderate TBI group. In comparison to adolescents with moderate TBI, those with severe TBI had significantly more parent-reported externalizing behaviors and self-reported weaknesses in social competence. SIP skills were strong predictors of problems and social competence in adolescents with TBI. More specifically, an aggressive SIP style predicted externalizing problems and a passive SIP style predicted internalizing problems. Both passive and aggressive SIP skills were related to social competence and social problems. Adolescents with TBI are at risk for deficits in social and behavioral outcomes. SIP skills are strongly related to behavior problems and social competence in adolescents with TBI. SIP skills, social competence, and behavior problems are important targets for intervention that may be amenable to change and lead to improved functional outcomes following TBI.

  3. Utility of CrIS/ATMS profiles to diagnose extratropical transition

    Science.gov (United States)

    Berndt, Emily; Folmer, Michael

    2018-03-01

    Anticipating changes in hurricane intensity can be challenging in data sparse regions of the North Atlantic Ocean. Hyperspectral infrared retrieved profiles have the potential to provide a wealth of information about the vertical structure of thermodynamic characteristics of the atmosphere such as temperature and moisture which can impact hurricane intensity. Increased forecaster situational awareness and identification of moist or dry layers in the near-storm environment can indicate impending changes in storm intensity. This investigation demonstrates the utility and value of hyperspectral infrared retrieved profiles to diagnose thermodynamic characteristics of the near-storm environment to anticipate changes in hurricane intensity.

  4. Is there a link between selectivity and binding thermodynamics profiles?

    Science.gov (United States)

    Tarcsay, Ákos; Keserű, György M

    2015-01-01

    Thermodynamics of ligand binding is influenced by the interplay between enthalpy and entropy contributions of the binding event. The impact of these binding free energy components, however, is not limited to the primary target only. Here, we investigate the relationship between binding thermodynamics and selectivity profiles by combining publicly available data from broad off-target assay profiling and the corresponding thermodynamics measurements. Our analysis indicates that compounds binding their primary targets with higher entropy contributions tend to hit more off-targets compared with those ligands that demonstrated enthalpy-driven binding. Copyright © 2014 Elsevier Ltd. All rights reserved.

  5. Comparisons of Crosswind Velocity Profile Estimates Used in Fast-Time Wake Vortex Prediction Models

    Science.gov (United States)

    Pruis, Mathew J.; Delisi, Donald P.; Ahmad, Nashat N.

    2011-01-01

    Five methods for estimating crosswind profiles used in fast-time wake vortex prediction models are compared in this study. Previous investigations have shown that temporal and spatial variations in the crosswind vertical profile have a large impact on the transport and time evolution of the trailing vortex pair. The most important crosswind parameters are the magnitude of the crosswind and the gradient in the crosswind shear. It is known that pulsed and continuous wave lidar measurements can provide good estimates of the wind profile in the vicinity of airports. In this study comparisons are made between estimates of the crosswind profiles from a priori information on the trajectory of the vortex pair as well as crosswind profiles derived from different sensors and a regional numerical weather prediction model.

  6. Study on residual stress across the pipes' thickness using outer surface rapid heating. Development of pipe outer surface irradiated laser stress improvement process (L-SIP)

    International Nuclear Information System (INIS)

    Ohta, Takahiro; Terasaki, Toshio

    2009-01-01

    The new process called L-SIP (outer surface irradiated Laser Stress Improvement Process) is developed to improve the tensile residual stress of the inner surface near the butt welded joints of pipes in the compression stress. The temperature gradient occurs in the thickness of pipes in heating the outer surface rapidly by laser beam. By the thermal expansion difference between the inner surface and the outer surface, the compression plastic strain generates near the outer surface and the tensile plastic strain generates near the inner surface of pipes. The compression stress occurs near the inner surface of pipes by the plastic deformation. In this paper, the theoretical equation which calculates residual stress distribution from the inherent strain distribution in the thickness of pipes is derived. And, the relation between the distribution of temperature and the residual stress in the thickness is examined for various pipes size. (1) By rapidly heating from the outer surface, the residual stress near the inner surface of the pipe is improved to the compression stress. (2) Pipes size hardly affects the distribution of the residual stress in the stainless steel pipes for piping (JISG3459). (3) The temperature rising area from the outside is smaller, the area of the compression residual stress near the inner surface becomes wider. (author)

  7. Detector for failed fuel elements

    International Nuclear Information System (INIS)

    Ito, Masaru.

    1979-01-01

    Purpose: To provide automatic monitor for the separation or reactor water and sampling water, in a failed fuel element detector using a sipping chamber. Constitution: A positional detector for the exact mounting of a sipping chamber on a channel box and a level detector for the detection of complete discharge of cooling water in the sipping chamber are provided in the sipping chamber. The positional detector is contacted to the upper end of the channel box and operated when the sipping chamber is correctly mounted to the fuel assemblies. The level detector comprises a float and a limit switch and it is operated when the water in the sipping chamber is discharged by a predetermined amount. Isolation of reactor water and sampling water are automatically monitored by the signal from these two detectors. (Ikeda, J.)

  8. Selection of a representative subset of global climate models that captures the profile of regional changes for integrated climate impacts assessment

    Directory of Open Access Journals (Sweden)

    Alex C. Ruane

    2017-03-01

    Full Text Available Abstract We present the Representative Temperature and Precipitation (T&P GCM Subsetting Approach developed within the Agricultural Model Intercomparison and Improvement Project (AgMIP to select a practical subset of global climate models (GCMs for regional integrated assessment of climate impacts when resource limitations do not permit the full ensemble of GCMs to be evaluated given the need to also focus on impacts sector and economics models. Subsetting inherently leads to a loss of information but can free up resources to explore important uncertainties in the integrated assessment that would otherwise be prohibitive. The Representative T&P GCM Subsetting Approach identifies five individual GCMs that capture a profile of the full ensemble of temperature and precipitation change within the growing season while maintaining information about the probability that basic classes of climate changes (relatively cool/wet, cool/dry, middle, hot/wet, and hot/dry are projected in the full GCM ensemble. We demonstrate the selection methodology for maize impacts in Ames, Iowa, and discuss limitations and situations when additional information may be required to select representative GCMs. We then classify 29 GCMs over all land areas to identify regions and seasons with characteristic diagonal skewness related to surface moisture as well as extreme skewness connected to snow-albedo feedbacks and GCM uncertainty. Finally, we employ this basic approach to recognize that GCM projections demonstrate coherence across space, time, and greenhouse gas concentration pathway. The Representative T&P GCM Subsetting Approach provides a quantitative basis for the determination of useful GCM subsets, provides a practical and coherent approach where previous assessments selected solely on availability of scenarios, and may be extended for application to a range of scales and sectoral impacts.

  9. The impact of the israeli transplantation law on the socio-demographic profile of living kidney donors.

    Science.gov (United States)

    Boas, H; Mor, E; Michowitz, R; Rozen-Zvi, B; Rahamimov, R

    2015-04-01

    The Israeli transplantation law of 2008 stipulated that organ trading is a criminal offense, and banned the reimbursement of such transplants by insurance companies, thus decreasing dramatically transplant tourism from Israel. We evaluated the law's impact on the number and the socio-demographic features of 575 consecutive living donors, transplanted in the largest Israeli transplantation center, spanning 5 years prior to 5 years after the law's implementation. Living kidney donations increased from 3.5 ± 1.5 donations per month in the pre-law period to 6.1 ± 2.4 per month post-law (p socio-demographic characteristics: mean age increased from 35.4 ± 7.4 to 39.9 ± 10.2 (p = 0.001), an increase in the proportion of donors with college level or higher education (31.0% to 63.1%; p tourism and organ trading in accordance with Istanbul Declaration, was associated with an increase in local transplantation activity, mainly from related living kidney donors, and a change in the profile of unrelated donors into an older, higher educated, white collar population. © Copyright 2015 The American Society of Transplantation and the American Society of Transplant Surgeons.

  10. Metabolite Profiling of Red Sea Corals

    KAUST Repository

    Ortega, Jovhana Alejandra

    2016-12-01

    Looking at the metabolite profile of an organism provides insights into the metabolomic state of a cell and hence also into pathways employed. Little is known about the metabolites produced by corals and their algal symbionts. In particular, corals from the central Red Sea are understudied, but interesting study objects, as they live in one of the warmest and most saline environments and can provide clues as to the adjustment of corals to environmental change. In this study, we applied gas chromatography – mass spectrometry (GC–MS) metabolite profiling to analyze the metabolic profile of four coral species and their associated symbionts: Fungia granulosa, Acropora hemprichii, Porites lutea, and Pocillopora verrucosa. We identified and quantified 102 compounds among primary and secondary metabolites across all samples. F. granulosa and its symbiont showed a total of 59 metabolites which were similar to the 51 displayed by P. verrucosa. P. lutea and A. hemprichii both harbored 40 compounds in conjunction with their respective isolated algae. Comparing across species, 28 metabolites were exclusively present in algae, while 38 were exclusive to corals. A principal component and cluster analyses revealed that metabolite profiles clustered between corals and algae, but each species harbored a distinct catalog of metabolites. The major classes of compounds were carbohydrates and amino acids. Taken together, this study provides a first description of metabolites of Red Sea corals and their associated symbionts. As expected, the metabolites of coral hosts differ from their algal symbionts, but each host and algal species harbor a unique set of metabolites. This corroborates that host-symbiont species pairs display a fine-tuned complementary metabolism that provide insights into the specific nature of the symbiosis. Our analysis also revealed aquatic pollutants, which suggests that metabolite profiling might be used for monitoring pollution levels and assessing

  11. The Impact of Herbal Drug Use on Adverse Drug Reaction Profiles of Patients on Antiretroviral Therapy in Zimbabwe

    Directory of Open Access Journals (Sweden)

    Tinashe Mudzviti

    2012-01-01

    Full Text Available Background. The main objective was to determine the impact of herbal drug use on adverse drug reactions in patients on antiretroviral therapy (ART. Methodology. Patients receiving first-line ART from the national roll-out program participated in this cross-sectional study. Participants were interviewed and a data collection sheet was used to collect information from the corresponding medical record. Results. The majority (98.2% of participants were using at least one herbal drug together with ART. The most common herbal remedies used were Allium Sativum (72.7%, Bidens pilosa (66.0%, Eucalyptus globulus (52.3%, Moringa oleifera (44.1%, Lippia javanica (36.3%, and Peltoforum africanum (34.3%. Two indigenous herbs, Musakavakadzi (OR=0.25; 95% CI 0.076–0.828 and Peltoforum africanum (OR=0.495; 95% CI 0.292–0.839 reduced the occurrence of adverse drug events. Conclusions. The use of herbal drugs is high in the HIV-infected population and there is need for pharmacovigilance programs to recognize the role they play in altering ADR profiles.

  12. The impact of cloud vertical profile on liquid water path retrieval based on the bispectral method: A theoretical study based on large-eddy simulations of shallow marine boundary layer clouds.

    Science.gov (United States)

    Miller, Daniel J; Zhang, Zhibo; Ackerman, Andrew S; Platnick, Steven; Baum, Bryan A

    2016-04-27

    Passive optical retrievals of cloud liquid water path (LWP), like those implemented for Moderate Resolution Imaging Spectroradiometer (MODIS), rely on cloud vertical profile assumptions to relate optical thickness ( τ ) and effective radius ( r e ) retrievals to LWP. These techniques typically assume that shallow clouds are vertically homogeneous; however, an adiabatic cloud model is plausibly more realistic for shallow marine boundary layer cloud regimes. In this study a satellite retrieval simulator is used to perform MODIS-like satellite retrievals, which in turn are compared directly to the large-eddy simulation (LES) output. This satellite simulator creates a framework for rigorous quantification of the impact that vertical profile features have on LWP retrievals, and it accomplishes this while also avoiding sources of bias present in previous observational studies. The cloud vertical profiles from the LES are often more complex than either of the two standard assumptions, and the favored assumption was found to be sensitive to cloud regime (cumuliform/stratiform). Confirming previous studies, drizzle and cloud top entrainment of dry air are identified as physical features that bias LWP retrievals away from adiabatic and toward homogeneous assumptions. The mean bias induced by drizzle-influenced profiles was shown to be on the order of 5-10 g/m 2 . In contrast, the influence of cloud top entrainment was found to be smaller by about a factor of 2. A theoretical framework is developed to explain variability in LWP retrievals by introducing modifications to the adiabatic r e profile. In addition to analyzing bispectral retrievals, we also compare results with the vertical profile sensitivity of passive polarimetric retrieval techniques.

  13. The impact of cloud vertical profile on liquid water path retrieval based on the bispectral method: A theoretical study based on large-eddy simulations of shallow marine boundary layer clouds

    Science.gov (United States)

    Miller, Daniel J.; Zhang, Zhibo; Ackerman, Andrew S.; Platnick, Steven; Baum, Bryan A.

    2018-01-01

    Passive optical retrievals of cloud liquid water path (LWP), like those implemented for Moderate Resolution Imaging Spectroradiometer (MODIS), rely on cloud vertical profile assumptions to relate optical thickness (τ) and effective radius (re) retrievals to LWP. These techniques typically assume that shallow clouds are vertically homogeneous; however, an adiabatic cloud model is plausibly more realistic for shallow marine boundary layer cloud regimes. In this study a satellite retrieval simulator is used to perform MODIS-like satellite retrievals, which in turn are compared directly to the large-eddy simulation (LES) output. This satellite simulator creates a framework for rigorous quantification of the impact that vertical profile features have on LWP retrievals, and it accomplishes this while also avoiding sources of bias present in previous observational studies. The cloud vertical profiles from the LES are often more complex than either of the two standard assumptions, and the favored assumption was found to be sensitive to cloud regime (cumuliform/stratiform). Confirming previous studies, drizzle and cloud top entrainment of dry air are identified as physical features that bias LWP retrievals away from adiabatic and toward homogeneous assumptions. The mean bias induced by drizzle-influenced profiles was shown to be on the order of 5–10 g/m2. In contrast, the influence of cloud top entrainment was found to be smaller by about a factor of 2. A theoretical framework is developed to explain variability in LWP retrievals by introducing modifications to the adiabatic re profile. In addition to analyzing bispectral retrievals, we also compare results with the vertical profile sensitivity of passive polarimetric retrieval techniques. PMID:29637042

  14. Sensitivity of molecular marker-based CMB models to biomass burning source profiles

    Science.gov (United States)

    Sheesley, Rebecca J.; Schauer, James J.; Zheng, Mei; Wang, Bo

    To assess the contribution of sources to fine particulate organic carbon (OC) at four sites in North Carolina, USA, a molecular marker chemical mass balance model (MM-CMB) was used to quantify seasonal contributions for 2 years. The biomass burning contribution at these sites was found to be 30-50% of the annual OC concentration. In order to provide a better understanding of the uncertainty in MM-CMB model results, a biomass burning profile sensitivity test was performed on the 18 seasonal composites. The results using reconstructed emission profiles based on published profiles compared well, while model results using a single source test profile resulted in biomass burning contributions that were more variable. The biomass burning contribution calculated using an average regional profile of fireplace emissions from five southeastern tree species also compared well with an average profile of open burning of pine-dominated forest from Georgia. The standard deviation of the results using different source profiles was a little over 30% of the annual average biomass contributions. Because the biomass burning contribution accounted for 30-50% of the OC at these sites, the choice of profile also impacted the motor vehicle source attribution due to the common emission of elemental carbon and polycyclic aromatic hydrocarbons. The total mobile organic carbon contribution was less effected by the biomass burning profile than the relative contributions from gasoline and diesel engines.

  15. Theoretical profiles of the spectral lines of the hydrogen atom; Profils theoriques des raies spectrales de l'atome d'hydrogene

    Energy Technology Data Exchange (ETDEWEB)

    Nguyen, H; Herman, L [Universite de la Sorbonne, Lab. de Recherche Physique, 75 - Paris (France); Drawin, H W [Commissariat a l' Energie Atomique, Fontenay-aux-Roses, Association Euratom-CEA, Groupe de Recherches sur la Fusion Controlee (France). Centre d' Etudes Nucleaires

    1965-07-01

    The line-broadening problem of the hydrogen lines has been formulated in the quasistatic approximation as far as the ions are concerned, and in the classical path approximation as far as the broadening due to collisions with electrons is concerned. These electrons interfere in different numerical results only by the self-correlation function of the fluctuating electrical field strength created at each point in the plasma. The Lewis correction has been applied, but using the whole velocity distribution function of the electrons. The formula which represents the usual impact profile, valid only for frequencies much smaller than the plasma frequency, has been extended using another formula which will be valid up to the neighbourhood of that spectral region where the quasi-static approximation begins to be valid also for the electrons. As an example, the line profile of Ly {alpha} is given by some graphs for T = 10{sup 4} deg. K and electron densities N = 10{sup 17} cm{sup -3} and N = 10{sup 18}cm{sup -3}. (authors) [French] Le probleme d'elargissement des raies de l'atome H est formule dans l'approximation quasi-statique en ce qui concerne les ions et dans l'approximation du chemin classique en ce qui concerne les electrons. Ceux-ci interviennent dans differents resultats uniquement par la fonction auto-correlation du champ electrique fluctuant qu'ils creent en chaque point du plasma. La correction de Lewis a ete appliquee mais en tenant compte de la distribution des vitesses electroniques. La formule donnant les profils d'impact habituels, valable seulement pour des frequences tres inferieures a la frequence du plasma, est ainsi prolongee de maniere continue par une autre formule, valable jusqu'au voisinage de la region spectrale ou l'approximation quasistatique commence a etre egalement justifiee pour les electrons. A titre d'illustration on represente graphiquement le profil de la raie Ly {alpha} pour T = 10{sup 4} deg. K et des densites electroniques de N = 10{sup

  16. Modular injector integrated linear apparatus with motion profile optimization for spatial atomic layer deposition

    Science.gov (United States)

    Wang, Xiaolei; Li, Yun; Lin, Jilong; Shan, Bin; Chen, Rong

    2017-11-01

    A spatial atomic layer deposition apparatus integrated with a modular injector and a linear motor has been designed. It consists of four parts: a precursor delivery manifold, a modular injector, a reaction zone, and a driving unit. An injector with multi-layer structured channels is designed to help improve precursor distribution homogeneity. During the back and forth movement of the substrate at high speed, the inertial impact caused by jerk and sudden changes of acceleration will degrade the film deposition quality. Such residual vibration caused by inertial impact will aggravate the fluctuation of the gap distance between the injector and the substrate in the deposition process. Thus, an S-curve motion profile is implemented to reduce the large inertial impact, and the maximum position error could be reduced by 84%. The microstructure of the film under the S-curve motion profile shows smaller root-mean-square and scanning voltage amplitude under an atomic force microscope, which verifies the effectiveness of the S-curve motion profile in reducing the residual vibration and stabilizing the gap distance between the injector and the substrate. The film deposition rate could reach 100 nm/min while maintaining good uniformity without obvious periodic patterns on the surface.

  17. Quantifying the benefits of achieving or maintaining long-term low risk profile for cardiovascular disease : The doetinchem cohort study

    NARCIS (Netherlands)

    Hulsegge, Gerben; Smit, Henriëtte A.; Van Der Schouw, Yvonne T.; Daviglus, Martha L.; Verschuren, W. M Monique

    2015-01-01

    Background: Studies investigating the relation between risk profiles and cardiovascular disease have measured risk at baseline only. We investigated maintenance and changes of risk profiles over time and their potential impact on incident cardiovascular disease. Design: Population-based cohort

  18. Quantifying the benefits of achieving or maintaining long-term low risk profile for cardiovascular disease: The Doetinchem Cohort Study

    NARCIS (Netherlands)

    Hulsegge, G.; Smit, H.A.; van der Schouw, Y.T.; Daviglus, M.L.; Verschuren, W.M.

    2015-01-01

    Background: Studies investigating the relation between risk profiles and cardiovascular disease have measured risk at baseline only. We investigated maintenance and changes of risk profiles over time and their potential impact on incident cardiovascular disease. Design: Population-based cohort

  19. THE IMPACTS OF GLOBALIZATION IN PROFILE OF WORK AND 21st CENTURY WORKER.

    Directory of Open Access Journals (Sweden)

    Marcelo Antonio Treff

    2013-06-01

    Full Text Available This article aims at evaluating the main socioeconomic changes that happened starting from the end of the 1980’s decade, in Brazil and in the world that imposed countless organizational transformations, particularly in a new profile of the workers and their competences.

  20. Surgery for benign prostatic hyperplasia: Profile of patients in a tertiary care institution.

    Science.gov (United States)

    Rajeev, Rahul; Giri, Bhuwan; Choudhary, Lok Prakash; Kumar, Rajeev

    2017-01-01

    Medical therapy is widely used for managing benign prostatic hyperplasia (BPH) and has made an impact on the profile of patients who ultimately undergo surgery. This changing profile may impact outcomes of surgery and associated complications. To assess the impact of medical management, we evaluated the profile of patients who had surgery for BPH at our institution. A retrospective chart-review was performed of patient demographics, indications for surgery, preoperative comorbid conditions and postoperative course in patients who underwent surgery for BPH over a 5-year period. The data were analysed for demographic trends in comparison with historical cohorts. A total of 327 patients underwent surgery for BPH between 2008 and 2012. Their mean age was 66.4 years, the mean prostate gland weight was 59.2 g and the mean duration of symptoms was 35.3 months; 34% had a prostate gland weight of >60 g; 1 59 (48.6%) patients had an absolute indication for surgery; 139 (42.5%) of these were catheterized and 6.1% of patients presented with azotaemia or upper tract changes without urinary retention. In comparison with historical cohorts, more patients are undergoing surgery for absolute indications including retention of urine and hydroureteronephrosis. However, the patients are younger, they have fewer comorbid conditions and have a similar rate of complications after the procedure.

  1. Impact of crystallisation processes on depth profile formation in sol-gel PbZr.sub.0·52./sub.Ti.sub.0·48./sub.O.sub.3./sub. thin films

    Czech Academy of Sciences Publication Activity Database

    Aulika, I.; Mergen, S.; Bencan, A.; Zhang, Q.; Dejneka, Alexandr; Kosec, M.; Kundzins, K.; Demarchi, D.; Civera, P.

    2013-01-01

    Roč. 112, č. 1 (2013), s. 53-58 ISSN 1743-6753 R&D Projects: GA TA ČR TA01010517; GA ČR GAP108/12/1941 Institutional research plan: CEZ:AV0Z10100522 Keywords : compositional and optical gradien * PZT * spectroscopic ellipsometry * crystallisation proces * sol-gel * XRD * thin films * depth profile * spectroscopic elipsometry Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 1.107, year: 2013

  2. Satisfaction with facial profile aesthetics: are norms overrated?

    Science.gov (United States)

    Manevska, I; Pavlic, A; Katic, V; Trinajstic Zrinski, M; Drevensek, M; Spalj, S

    2018-01-01

    This study aimed to explore to what extent adults perceive deviations from the norm of a balanced profile with normal occlusion as reducing satisfaction with facial appearance and having a psychosocial impact. This cross-sectional study included 225 Caucasian subjects (64% women) aged 18-42 years. Their facial profiles were analyzed photogrammetrically and they were classified into three categories: within, below, or above the standard range for the Croatian population with a normal occlusion. Psychosocial issues were assessed by self-reported satisfaction with facial appearance and domains from the Orthognathic Quality of Life Questionnaire: social aspects of dentofacial aesthetics (SA), facial aesthetics concern (FA), and awareness of dentofacial aesthetics (AW). Men with a concave profile were less satisfied with their faces than those with a flat or convex profile (P<0.05). A reduced upper lip height in men resulted in a lower level of satisfaction and increased FA score, when compared to men with a normal or increased upper lip height (P<0.05). In women, a reduced middle third of the face increased AW (P=0.045). Deviations from a well-balanced facial profile, as well as the morphology of the nose and lip, do not increase psychosocial issues to a great extent. The range of acceptable facial characteristics is evidently much broader than the norms. Copyright © 2017 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

  3. Motor and Executive Function Profiles in Adult Residents ...

    Science.gov (United States)

    Objective: Exposure to elevated levels of manganese (Mn) may be associated with tremor, motor and executive dysfunction (EF), clinically resembling Parkinson’s disease (PD). PD research has identified tremor-dominant (TD) and non-tremor dominant (NTD) profiles. NTD PD presents with bradykinesia, rigidity, and postural sway, and is associated with EF impairment with lower quality of life (QoL). Presence and impact of tremor, motor, and executive dysfunction profiles on health-related QoL and life satisfaction were examined in air-Mn exposed residents of two Ohio, USA towns. Participants and Methods: From two Ohio towns exposed to air-Mn, 186 residents (76 males) aged 30-75 years were administered measures of EF (Animal Naming, ACT, Rey-O Copy, Stroop Color-Word, and Trails B), motor and tremor symptoms (UPDRS), QoL (BRFSS), life satisfaction (SWLS), and positive symptom distress (SCL-90-R). Air-Mn exposure in the two towns was modeled with 10 years of air-monitoring data. Cluster analyses detected the presence of symptom profiles by grouping together residents with similar scores on these measures. Results: Overall, mean air-Mn concentration for the two towns was 0.53 µg/m3 (SD=.92). Two-step cluster analyses identified TD and NTD symptom profiles. Residents in the NTD group lacked EF impairment; EF impairment represented a separate profile. An unimpaired group also emerged. The NTD and EF impairment groups were qualitatively similar, with relatively lo

  4. Beware of Selfies: The Impact of Photo Type on Impression Formation Based on Social Networking Profiles.

    Science.gov (United States)

    Krämer, Nicole C; Feurstein, Markus; Kluck, Jan P; Meier, Yannic; Rother, Marius; Winter, Stephan

    2017-01-01

    Users of social networking sites such as Facebook frequently post self-portraits on their profiles. While research has begun to analyze the motivations for posting such pictures, less is known about how selfies are evaluated by recipients. Although producers of selfies typically aim to create a positive impression, selfies may also be regarded as narcissistic and therefore fail to achieve the intended goal. The aim of this study is to examine the potentially ambivalent reception of selfies compared to photos taken by others based on the Brunswik lens model Brunswik (1956). In a between-subjects online experiment ( N = 297), Facebook profile mockups were shown which differed with regard to picture type (selfie vs. photo taken by others), gender of the profile owner (female vs. male), and number of individuals within a picture (single person vs. group). Results revealed that selfies were indeed evaluated more negatively than photos taken by others. Persons in selfies were rated as less trustworthy, less socially attractive, less open to new experiences, more narcissistic and more extroverted than the same persons in photos taken by others. In addition, gender differences were observed in the perception of pictures. Male profile owners were rated as more narcissistic and less trustworthy than female profile owners, but there was no significant interaction effect of type of picture and gender. Moreover, a mediation analysis of presumed motives for posting selfies revealed that negative evaluations of selfie posting individuals were mainly driven by the perceived motivation of impression management. Findings suggest that selfies are likely to be evaluated less positively than producers of selfies might suppose.

  5. Quantitative depth profiling of K-doped fullerene films using XPS and SIMS

    Czech Academy of Sciences Publication Activity Database

    Oswald, S.; Janda, Pavel; Dunsch, L.

    2003-01-01

    Roč. 141, 1-2 (2003), s. 79-85 E-ISSN 1436-5073 Institutional research plan: CEZ:AV0Z4040901 Keywords : XPS * SIMS * depth profiling * fullerenes * doping Subject RIV: CG - Electrochemistry Impact factor: 0.784, year: 2003

  6. 'Changing climate, changing health, changing stories' profile: using an EcoHealth approach to explore impacts of climate change on inuit health.

    Science.gov (United States)

    Harper, S L; Edge, V L; Cunsolo Willox, A

    2012-03-01

    Global climate change and its impact on public health exemplify the challenge of managing complexity and uncertainty in health research. The Canadian North is currently experiencing dramatic shifts in climate, resulting in environmental changes which impact Inuit livelihoods, cultural practices, and health. For researchers investigating potential climate change impacts on Inuit health, it has become clear that comprehensive and meaningful research outcomes depend on taking a systemic and transdisciplinary approach that engages local citizens in project design, data collection, and analysis. While it is increasingly recognised that using approaches that embrace complexity is a necessity in public health, mobilizing such approaches from theory into practice can be challenging. In 2009, the Rigolet Inuit Community Government in Rigolet, Nunatsiavut, Canada partnered with a transdisciplinary team of researchers, health practitioners, and community storytelling facilitators to create the Changing Climate, Changing Health, Changing Stories project, aimed at developing a multi-media participatory, community-run methodological strategy to gather locally appropriate and meaningful data to explore climate-health relationships. The goal of this profile paper is to describe how an EcoHealth approach guided by principles of transdisciplinarity, community participation, and social equity was used to plan and implement this climate-health research project. An overview of the project, including project development, research methods, project outcomes to date, and challenges encountered, is presented. Though introduced in this one case study, the processes, methods, and lessons learned are broadly applicable to researchers and communities interested in implementing EcoHealth approaches in community-based research.

  7. Impact of the Assimilation of Hyperspectral Infrared Profiles on Advanced Weather and Research Model Simulations of a Non-Convective Wind Event

    Science.gov (United States)

    Berndt, Emily B.; Zavodsky, Bradley T; Jedlovec, Gary J.; Elmer, Nicholas J.

    2013-01-01

    Non-convective wind events commonly occur with passing extratropical cyclones and have significant societal and economic impacts. Since non-convective winds often occur in the absence of specific phenomena such as a thunderstorm, tornado, or hurricane, the public are less likely to heed high wind warnings and continue daily activities. Thus non-convective wind events result in as many fatalities as straight line thunderstorm winds. One physical explanation for non-convective winds includes tropopause folds. Improved model representation of stratospheric air and associated non-convective wind events could improve non-convective wind forecasts and associated warnings. In recent years, satellite data assimilation has improved skill in forecasting extratropical cyclones; however errors still remain in forecasting the position and strength of extratropical cyclones as well as the tropopause folding process. The goal of this study is to determine the impact of assimilating satellite temperature and moisture retrieved profiles from hyperspectral infrared (IR) sounders (i.e. Atmospheric Infrared Sounder (AIRS), Cross-track Infrared and Microwave Sounding Suite (CrIMSS), and Infrared Atmospheric Sounding Interferometer (IASI)) on the model representation of the tropopause fold and an associated high wind event that impacted the Northeast United States on 09 February 2013. Model simulations using the Advanced Research Weather Research and Forecasting Model (ARW) were conducted on a 12-km grid with cycled data assimilation mimicking the operational North American Model (NAM). The results from the satellite assimilation run are compared to a control experiment (without hyperspectral IR retrievals), North American Regional Reanalysis (NARR) reanalysis, and Rapid Refresh analyses.

  8. Aesthetic evaluation of profile incisor inclination.

    Science.gov (United States)

    Ghaleb, Nathalie; Bouserhal, Joseph; Bassil-Nassif, Nayla

    2011-06-01

    The objectives of this study were to evaluate (1) the impact of maxillary incisor inclination on the aesthetics of the profile view of a smile, (2) to determine the most aesthetic inclination in the profile view of a smile and correlate it with facial features, and (3) to determine if dentists, orthodontists, and laypeople appreciate differently incisor inclination in smile aesthetics. A smiling profile photograph of a female subject (22 years of age) who fulfilled the criteria of soft tissue normative values and a balanced smile was obtained. The photograph was manipulated to simulate six lingual and labial inclinations at 5 degree increments to a maximum of 15 degrees. The seven photographs were randomly distributed in a binder to three groups of raters (30 dentists, 30 orthodontists, and 30 laypeople) who scored the attractiveness of the photographic variations using a visual analogue scale. Comparison of the mean scores was carried out by repeated analysis of variance, univariate tests, and multiple Bonferroni comparisons. The results showed a statistically significant interaction between the rater's profession and the aesthetic preference of incisor inclination (P = 0.013). The profile smile corresponding to an increase of 5 degrees in a labial direction had the highest score among all professions and among male and female raters. Orthodontists preferred labial crown torque; dentists and laypeople did not appreciate excessive incisor inclination in either the lingual or the labial directions. The most preferred smile matched with a maxillary incisor inclined 93 degrees to the horizontal line and +7 degrees to the lower facial third.

  9. The impact of molecular emission in compositional depth profiling using Glow Discharge-Optical Emission Spectroscopy

    International Nuclear Information System (INIS)

    Bengtson, Arne

    2008-01-01

    The scope of this paper is to investigate and discuss how molecular emission can affect elemental analysis in glow discharge optical emission (GD-OES), particularly in compositional depth profiling (CDP) applications. Older work on molecular emission in glow discharges is briefly reviewed, and the nature of molecular emission spectra described. Work on the influence of hydrogen in the plasma, in particular elevated background due to a continuum spectrum, is discussed. More recent work from sputtering of polymers and other materials with a large content of light elements in a Grimm type source is reviewed, where substantial emission has been observed from several light diatomic molecules (CO, CH, OH, NH, C 2 ). It is discussed how the elevated backgrounds from such molecular emission can lead to significant analytical errors in the form of 'false' depth profile signals of several atomic analytical lines. Results from a recent investigation of molecular emission spectra from mixed gases in a Grimm type glow discharge are presented. An important observation is that dissociation and subsequent recombination processes occur, leading to formation of molecular species not present in the original plasma gas. Experimental work on depth profiling of a polymer coating and a thin silicate film, using a spectrometer equipped with channels for molecular emission lines, is presented. The results confirm that molecular emission gives rise to apparent depth profiles of elements not present in the sample. The possibilities to make adequate corrections for such molecular emission in CDP of organic coatings and very thin films are discussed

  10. The impact of molecular emission in compositional depth profiling using Glow Discharge-Optical Emission Spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Bengtson, Arne [Corrosion and Metals Research Institute, Dr. Kristinas vaeg 48, Stockholm (Sweden)], E-mail: arne.bengtson@kimab.com

    2008-09-15

    The scope of this paper is to investigate and discuss how molecular emission can affect elemental analysis in glow discharge optical emission (GD-OES), particularly in compositional depth profiling (CDP) applications. Older work on molecular emission in glow discharges is briefly reviewed, and the nature of molecular emission spectra described. Work on the influence of hydrogen in the plasma, in particular elevated background due to a continuum spectrum, is discussed. More recent work from sputtering of polymers and other materials with a large content of light elements in a Grimm type source is reviewed, where substantial emission has been observed from several light diatomic molecules (CO, CH, OH, NH, C{sub 2}). It is discussed how the elevated backgrounds from such molecular emission can lead to significant analytical errors in the form of 'false' depth profile signals of several atomic analytical lines. Results from a recent investigation of molecular emission spectra from mixed gases in a Grimm type glow discharge are presented. An important observation is that dissociation and subsequent recombination processes occur, leading to formation of molecular species not present in the original plasma gas. Experimental work on depth profiling of a polymer coating and a thin silicate film, using a spectrometer equipped with channels for molecular emission lines, is presented. The results confirm that molecular emission gives rise to apparent depth profiles of elements not present in the sample. The possibilities to make adequate corrections for such molecular emission in CDP of organic coatings and very thin films are discussed.

  11. Decentralized session initiation protocol solution in ad hoc networks

    Science.gov (United States)

    Han, Lu; Jin, Zhigang; Shu, Yantai; Dong, Linfang

    2006-10-01

    With the fast development of ad hoc networks, SIP has attracted more and more attention in multimedia service. This paper proposes a new architecture to provide SIP service for ad hoc users, although there is no centralized SIP server deployed. In this solution, we provide the SIP service by the introduction of two nodes: Designated SIP Server (DS) and its Backup Server (BDS). The nodes of ad hoc network designate DS and BDS when they join the session nodes set and when some pre-defined events occur. A new sip message type called REGISTRAR is presented so nodes can send others REGISTRAR message to declare they want to be DS. According to the IP information taken in the message, an algorithm works like the election of DR and BDR in OSPF protocol is used to vote DS and BDS SIP servers. Naturally, the DS will be replaced by BDS when the DS is down for predicable or unpredictable reasons. To facilitate this, the DS should register to the BDS and transfer a backup of the SIP users' database. Considering the possibility DS or BDS may abruptly go down, a special policy is given. When there is no DS and BDS, a new election procedure is triggered just like the startup phase. The paper also describes how SIP works normally in the decentralized model as well as the evaluation of its performance. All sessions based on SIP in ad hoc such as DS voting have been tested in the real experiments within a 500m*500m square area where about 30 random nodes are placed.

  12. Characteristics between the meshing pairs with different envelope profile in single screw compressors

    Science.gov (United States)

    Huang, R.; Liu, F.; Li, T.; Feng, Q.

    2017-08-01

    Single screw compressors have been used in various industrial fields. However, because the star-wheel teeth are easy to wear, the market for the development of single screw compressors is limited. In order to extend the service life of the star-wheel, researchers have developed different kinds of star-wheel tooth profile, such as single line envelope profile, single column envelope profile, and multi-column envelope profile. These profiles greatly affect the lubrication characteristics between the star-wheel teeth and the screw grooves. In this article, the lubrication characteristics between the meshing pairs with different envelope profiles are analyzed. Results show that the pressure peak of the single line envelope profile, single column envelope profile, and multi-column envelope profile are 3.23×105Pa, 3.38×105Pa, and 4.31×105Pa, respectively. This means that the multi-column enveloped meshing pair can resist the biggest external impact load. The deviation angle (γ) of the single line envelope profile, single column envelope profile, and multi-column envelope profile are 0.0139°~0.0286°, 0.0225°~0.0306° and 0.0122°~0.0262°, respectively. Thus, the self-balancing ability of the multi-column enveloped meshing pair is the strongest, and the oil film thickness on both sides of the multi-column enveloped star-wheel tooth is the most reasonable, which indicates a good lubrication state during operation, that is, longer operation life of the star-wheel teeth.

  13. A Mechanically Proved and an Incremental Development of the Session Initiation Protocol INVITE Transaction

    Directory of Open Access Journals (Sweden)

    Rajaa Filali

    2014-01-01

    Full Text Available The Session Initiation Protocol (SIP is an application layer signaling protocol used to create, manage, and terminate sessions in an IP based network. SIP is considered as a transactional protocol. There are two main SIP transactions, the INVITE transaction and the non-INVITE transaction. The SIP INVITE transaction specification is described in an informal way in Request for Comments (RFC 3261 and modified in RFC 6026. In this paper we focus on the INVITE transaction of SIP, over reliable and unreliable transport mediums, which is used to initiate a session. In order to ensure the correctness of SIP, the INVITE transaction is modeled and verified using event-B method and its Rodin platform. The Event-B refinement concept allows an incremental development by defining the studied system at different levels of abstraction, and Rodin discharges almost all proof obligations at each level. This interaction between modeling and proving reduces the complexity and helps in assuring that the INVITE transaction SIP specification is correct, unambiguous, and easy to understand.

  14. Metabolic profile in different cathegories of diary cowst

    Directory of Open Access Journals (Sweden)

    Ulchar Igor

    2008-11-01

    Full Text Available Knowing the values of the metabolic profile is important for prevention of so-called "production diseases" which have significant negative impact on the milk production. The aim of these investigations was determination of the metabolic profile and its referent values in the diary cows in several farms. Investigations included four categories of diary cows: pregnant heifers, cows in early lactation, cows in late lactation and dry cows. Discussion explains both significant differences of values of some parameters (glucosis, total proteins, urea, creatinine, AST, GGT in different groups of animals which were investigated and significant correlations between some parameters (glucosis, total protein, albumin, calcium, phosphorus, urea, creatinine, cholesterol, triglycerids, AST, GGT within each of groups of animals. The values gained with our investigations were compared with the referent values. It was found that cows included in our investigations were good metabolic profile, although their values were in some degree different from the referent values. Cows which were in lactation, especially the early lactation, had disposition of development of energy-protein deficit, but the disposition to calcium deficit was low.

  15. Market impact and trading profile of hidden orders in stock markets.

    Science.gov (United States)

    Moro, Esteban; Vicente, Javier; Moyano, Luis G; Gerig, Austin; Farmer, J Doyne; Vaglica, Gabriella; Lillo, Fabrizio; Mantegna, Rosario N

    2009-12-01

    We empirically study the market impact of trading orders. We are specifically interested in large trading orders that are executed incrementally, which we call hidden orders. These are statistically reconstructed based on information about market member codes using data from the Spanish Stock Market and the London Stock Exchange. We find that market impact is strongly concave, approximately increasing as the square root of order size. Furthermore, as a given order is executed, the impact grows in time according to a power law; after the order is finished, it reverts to a level of about 0.5-0.7 of its value at its peak. We observe that hidden orders are executed at a rate that more or less matches trading in the overall market, except for small deviations at the beginning and end of the order.

  16. Data Profiling

    OpenAIRE

    Hladíková, Radka

    2010-01-01

    Title: Data Profiling Author: Radka Hladíková Department: Department of Software Engineering Supervisor: Ing. Vladimír Kyjonka Supervisor's e-mail address: Abstract: This thesis puts mind on problems with data quality and data profiling. This Work analyses and summarizes problems of data quality, data defects, process of data quality, data quality assessment and data profiling. The main topic is data profiling as a process of researching data available in existing...

  17. Role of the pituitary-adrenal hormones in the acquisition of schedule-induced polydipsia.

    Science.gov (United States)

    Levine, R; Levine, S

    1989-06-01

    Adrenalectomized female rats failed to develop schedule-induced polydipsia (SIP). Dexamethasone (DEX) injections failed to reinstate SIP in adrenalectomized rats. They did not prevent intact rats from acquiring SIP but interfered with subsequent expression of this behavior. In contrast, corticosterone, the rats' normally occurring glucocorticoid, fully restored the acquisition and subsequent expression of SIP in adrenalectomized rats. This strongly suggests that corticosterone plays an essential role in the normal acquisition and development of this behavior. Data are interpreted in the context of current information concerning adrenal hormone receptors. It is hypothesized SIP acquisition is at least partly regulated by the Type I (mineralocorticoid) receptor.

  18. 77 FR 59100 - Approval and Promulgation of Implementation Plans; Alabama: General and Transportation Conformity...

    Science.gov (United States)

    2012-09-26

    ... Promulgation of Implementation Plans; Alabama: General and Transportation Conformity & New Source Review... (SMC) Rule. The SIP revision also changes the State's general and transportation conformity regulations... federal general and transportation conformity regulations into the SIP. Alabama's May 2, 2011, SIP...

  19. The Fatty Acid Profile Analysis of Cyperus laxus Used for Phytoremediation of Soils from Aged Oil Spill-Impacted Sites Revealed That This Is a C18:3 Plant Species.

    Directory of Open Access Journals (Sweden)

    Noemí Araceli Rivera Casado

    Full Text Available The effect of recalcitrant hydrocarbons on the fatty acid profile from leaf, basal corm, and roots of Cyperus laxus plants cultivated in greenhouse phytoremediation systems of soils from aged oil spill-impacted sites containing from 16 to 340 g/Kg total hydrocarbons (THC was assessed to investigate if this is a C18:3 species and if the hydrocarbon removal during the phytoremediation process has a relationship with the fatty acid profile of this plant. The fatty acid profile was specific to each vegetative organ and was strongly affected by the hydrocarbons level in the impacted sites. Leaf extracts of plants from uncontaminated soil produced palmitic acid (C16, octadecanoic acid (C18:0, unsaturated oleic acids (C18:1-C18:3, and unsaturated eichosanoic (C20:2-C20:3 acids with a noticeable absence of the unsaturated hexadecatrienoic acid (C16:3; this finding demonstrates, for the first time, that C. laxus is a C18:3 plant. In plants from the phytoremediation systems, the total fatty acid contents in the leaf and the corm were negatively affected by the hydrocarbons presence; however, the effect was positive in root. Interestingly, under contaminated conditions, unusual fatty acids such as odd numbered carbons (C15, C17, C21, and C23 and uncommon unsaturated chains (C20:3n6 and C20:4 were produced together with a remarkable quantity of C22:2 and C24:0 chains in the corm and the leaf. These results demonstrate that weathered hydrocarbons may drastically affect the lipidic composition of C. laxus at the fatty acid level, suggesting that this species adjusts the cover lipid composition in its vegetative organs, mainly in roots, in response to the weathered hydrocarbon presence and uptake during the phytoremediation process.

  20. The Fatty Acid Profile Analysis of Cyperus laxus Used for Phytoremediation of Soils from Aged Oil Spill-Impacted Sites Revealed That This Is a C18:3 Plant Species

    Science.gov (United States)

    Montes Horcasitas, María del Carmen; Rodríguez Vázquez, Refugio; Esparza García, Fernando José; Pérez Vargas, Josefina; Ariza Castolo, Armando; Ferrera-Cerrato, Ronald; Gómez Guzmán, Octavio

    2015-01-01

    The effect of recalcitrant hydrocarbons on the fatty acid profile from leaf, basal corm, and roots of Cyperus laxus plants cultivated in greenhouse phytoremediation systems of soils from aged oil spill-impacted sites containing from 16 to 340 g/Kg total hydrocarbons (THC) was assessed to investigate if this is a C18:3 species and if the hydrocarbon removal during the phytoremediation process has a relationship with the fatty acid profile of this plant. The fatty acid profile was specific to each vegetative organ and was strongly affected by the hydrocarbons level in the impacted sites. Leaf extracts of plants from uncontaminated soil produced palmitic acid (C16), octadecanoic acid (C18:0), unsaturated oleic acids (C18:1-C18:3), and unsaturated eichosanoic (C20:2-C20:3) acids with a noticeable absence of the unsaturated hexadecatrienoic acid (C16:3); this finding demonstrates, for the first time, that C. laxus is a C18:3 plant. In plants from the phytoremediation systems, the total fatty acid contents in the leaf and the corm were negatively affected by the hydrocarbons presence; however, the effect was positive in root. Interestingly, under contaminated conditions, unusual fatty acids such as odd numbered carbons (C15, C17, C21, and C23) and uncommon unsaturated chains (C20:3n6 and C20:4) were produced together with a remarkable quantity of C22:2 and C24:0 chains in the corm and the leaf. These results demonstrate that weathered hydrocarbons may drastically affect the lipidic composition of C. laxus at the fatty acid level, suggesting that this species adjusts the cover lipid composition in its vegetative organs, mainly in roots, in response to the weathered hydrocarbon presence and uptake during the phytoremediation process. PMID:26473488

  1. The Fatty Acid Profile Analysis of Cyperus laxus Used for Phytoremediation of Soils from Aged Oil Spill-Impacted Sites Revealed That This Is a C18:3 Plant Species.

    Science.gov (United States)

    Rivera Casado, Noemí Araceli; Montes Horcasitas, María del Carmen; Rodríguez Vázquez, Refugio; Esparza García, Fernando José; Pérez Vargas, Josefina; Ariza Castolo, Armando; Ferrera-Cerrato, Ronald; Gómez Guzmán, Octavio; Calva Calva, Graciano

    2015-01-01

    The effect of recalcitrant hydrocarbons on the fatty acid profile from leaf, basal corm, and roots of Cyperus laxus plants cultivated in greenhouse phytoremediation systems of soils from aged oil spill-impacted sites containing from 16 to 340 g/Kg total hydrocarbons (THC) was assessed to investigate if this is a C18:3 species and if the hydrocarbon removal during the phytoremediation process has a relationship with the fatty acid profile of this plant. The fatty acid profile was specific to each vegetative organ and was strongly affected by the hydrocarbons level in the impacted sites. Leaf extracts of plants from uncontaminated soil produced palmitic acid (C16), octadecanoic acid (C18:0), unsaturated oleic acids (C18:1-C18:3), and unsaturated eichosanoic (C20:2-C20:3) acids with a noticeable absence of the unsaturated hexadecatrienoic acid (C16:3); this finding demonstrates, for the first time, that C. laxus is a C18:3 plant. In plants from the phytoremediation systems, the total fatty acid contents in the leaf and the corm were negatively affected by the hydrocarbons presence; however, the effect was positive in root. Interestingly, under contaminated conditions, unusual fatty acids such as odd numbered carbons (C15, C17, C21, and C23) and uncommon unsaturated chains (C20:3n6 and C20:4) were produced together with a remarkable quantity of C22:2 and C24:0 chains in the corm and the leaf. These results demonstrate that weathered hydrocarbons may drastically affect the lipidic composition of C. laxus at the fatty acid level, suggesting that this species adjusts the cover lipid composition in its vegetative organs, mainly in roots, in response to the weathered hydrocarbon presence and uptake during the phytoremediation process.

  2. Utility of CrIS/ATMS profiles to diagnose extratropical transition

    Directory of Open Access Journals (Sweden)

    Emily Berndt

    2018-03-01

    Full Text Available Anticipating changes in hurricane intensity can be challenging in data sparse regions of the North Atlantic Ocean. Hyperspectral infrared retrieved profiles have the potential to provide a wealth of information about the vertical structure of thermodynamic characteristics of the atmosphere such as temperature and moisture which can impact hurricane intensity. Increased forecaster situational awareness and identification of moist or dry layers in the near-storm environment can indicate impending changes in storm intensity. This investigation demonstrates the utility and value of hyperspectral infrared retrieved profiles to diagnose thermodynamic characteristics of the near-storm environment to anticipate changes in hurricane intensity. Keywords: Hurricane, Sounding, Satellite

  3. Review of data types for the SKB site investigation programme

    Energy Technology Data Exchange (ETDEWEB)

    Klos, Richard

    2002-11-01

    SKB is currently undertaking a detailed site investigation programme (SIP) to characterise the geology and surface ecosystems in areas around potential sites for a planned repository for spent nuclear fuel. This report reviews site specific and generic data types needed to characterise biosphere processes relevant to the evaluation of long-term radiological safety in the context of assessments of future impacts arising from the deep geologic disposal of spent nuclear fuel. Focus is on the types of data that make up the different elements of radiological assessment models and how the data used relate to site-specific characteristics. The relevance of the SIP to the development of assessment models for long-term assessment is addressed, including the representation of the geosphere-biosphere interface. Reference to SKB's programme is made in order to determine how well the current programme will meet the needs of assessment models that will be developed and used in the assessment of long-term safety. The review also provides SSI with a basis for the planning of further SSI R and D work. The process, by which site-specific information is converted into a form suitable for use in numerical assessment models, can be quite complex. An overview of assessment model concepts is provided and the links between these and real-word site information considered. Focusing on the needs of assessment models, the review provides a summary of the main types of analyses and site-specific models that are needed for safety evaluations. Review of the SIP indicates that information from the programme feeds into a set of detailed site description models. However there is a gap between the descriptive components and the detailed model descriptions needed to configure numerical assessment models. Details of system evolution are not clearly dealt with in the programme. The SIP focuses on a detailed description of the site the present day. However, radiological impacts are not expected to

  4. Review of data types for the SKB site investigation programme

    International Nuclear Information System (INIS)

    Klos, Richard

    2002-11-01

    SKB is currently undertaking a detailed site investigation programme (SIP) to characterise the geology and surface ecosystems in areas around potential sites for a planned repository for spent nuclear fuel. This report reviews site specific and generic data types needed to characterise biosphere processes relevant to the evaluation of long-term radiological safety in the context of assessments of future impacts arising from the deep geologic disposal of spent nuclear fuel. Focus is on the types of data that make up the different elements of radiological assessment models and how the data used relate to site-specific characteristics. The relevance of the SIP to the development of assessment models for long-term assessment is addressed, including the representation of the geosphere-biosphere interface. Reference to SKB's programme is made in order to determine how well the current programme will meet the needs of assessment models that will be developed and used in the assessment of long-term safety. The review also provides SSI with a basis for the planning of further SSI R and D work. The process, by which site-specific information is converted into a form suitable for use in numerical assessment models, can be quite complex. An overview of assessment model concepts is provided and the links between these and real-word site information considered. Focusing on the needs of assessment models, the review provides a summary of the main types of analyses and site-specific models that are needed for safety evaluations. Review of the SIP indicates that information from the programme feeds into a set of detailed site description models. However there is a gap between the descriptive components and the detailed model descriptions needed to configure numerical assessment models. Details of system evolution are not clearly dealt with in the programme. The SIP focuses on a detailed description of the site the present day. However, radiological impacts are not expected to reach

  5. Quality Control Algorithms and Proposed Integration Process for Wind Profilers Used by Launch Vehicle Systems

    Science.gov (United States)

    Decker, Ryan; Barbre, Robert E., Jr.

    2011-01-01

    Impact of winds to space launch vehicle include Design, Certification Day-of-launch (DOL) steering commands (1)Develop "knockdowns" of load indicators (2) Temporal uncertainty of flight winds. Currently use databases from weather balloons. Includes discrete profiles and profile pair datasets. Issues are : (1)Larger vehicles operate near design limits during ascent 150 discrete profiles per month 110-217 seasonal 2.0 and 3.5-hour pairs Balloon rise time (one hour) and drift (up to 100 n mi) Advantages of the Alternative approach using Doppler Radar Wind Profiler (DRWP) are: (1) Obtain larger sample size (2) Provide flexibility for assessing trajectory changes due to winds (3) Better representation of flight winds.

  6. Impact of the "salary scholarship" impact profile and student achievement.

    Directory of Open Access Journals (Sweden)

    Berlanga, Vanesa

    2013-08-01

    Full Text Available In Spain, within the framework of the Strategy 2015, the implementation of scholarships, grants and wages especially adapted to the new situation of the European Higher Education, intended to ensure access to university education to those most disadvantaged social groups economically. This research makes an ex post facto, descriptive-comparative aimed at assessing the impact of the grant salary, as an economic factor, on equity, access and academic performance in the first year of college. The study was conducted with a total of 10,394 new students in the 2010-11 cohort at the University of Barcelona, from the database from the institution itself. A total of 642 students agreed to grant salary, with differences depending on the branch of knowledge, gender, and the path to college. In relation to their peers, scholarship students come from families with occupations and / or study less, so scholarships model contributes to equity in access. In relation to performance analysis, scholarship students enrolled and present, on average, a larger number of subjects in order to meet the academic requirements for scholarship renewal, but the results are final academic in several branches knowledge, influenced negatively. One possible explanation is the largest academic pressure of this group in a phase usually complicated: the transition to college.

  7. Assessment and Evaluation of Quality of Life (OHRQoL) of Patients with Dental Implants Using the Oral Health Impact Profile (OHIP-14) - A Clinical Study.

    Science.gov (United States)

    Alzarea, Bader K

    2016-04-01

    Peri-implant tissue health is a requisite for success of dental implant therapy. Plaque accumulation leads to initiation of gingivitis around natural teeth and peri-implantitis around dental implants. Peri-implantitis around dental implants may result in implant placement failure. For obtaining long-term success, timely assessment of dental implant site is mandatory. To assess and evaluate Quality of Life (OHRQoL) of individuals with dental implants using the Oral Health Impact Profile (OHIP-14). Total 92 patients were evaluated for assessment of the health of peri-implant tissues by recording, Plaque Index (PI), Probing Pocket Depth (PD), Bleeding On Probing (BOP) and Probing Attachment Level (PAL) as compared to contra-lateral natural teeth (control). In the same patients Quality of Life Assessment was done by utilizing Oral Health Impact Profile Index (OHIP-14). The mean plaque index around natural teeth was more compared to implants and it was statistically significant. Other three dimensions mean bleeding on probing; mean probing attachment level and mean pocket depth around both natural teeth and implant surfaces was found to be not statistically significant. OHIP-14 revealed that patients with dental implants were satisfied with their Oral Health-Related Quality of Life (OHRQoL). Similar inflammatory conditions are present around both natural teeth and implant prostheses as suggested by results of mean plaque index, mean bleeding on probing, mean pocket depth and mean probing attachment level, hence reinforcing the periodontal health maintenance both prior to and after incorporation of dental implants. Influence of implant prostheses on patient's oral health related quality of life (as depicted by OHIP-14) and patients' perceptions and expectations may guide the clinician in providing the best implant services.

  8. 75 FR 48895 - Approval and Promulgation of Air Quality Implementation Plans; MN

    Science.gov (United States)

    2010-08-12

    ... Promulgation of Air Quality Implementation Plans; MN AGENCY: Environmental Protection Agency (EPA). ACTION... Plan (SIP) for sulfur dioxide (SO 2 ). The Minnesota Pollution Control Agency submitted the SIP... request would revise SIP requirements applicable to Saint Mary's Hospital, located in Rochester, Minnesota...

  9. 75 FR 30409 - Centers for Disease Control and Prevention

    Science.gov (United States)

    2010-06-01

    ... applications received in response to ``Workplace Health Research Network (WHRN)--Coordinating Center, SIP 10-031 and WHRN--Collaborating Centers, SIP 10-032, initial review.'' Contact Person for More Information..., Disability, and Injury Prevention and Control Special Interest Projects (SIPs): Workplace Health Research...

  10. The impact of mild induced hypothermia on the rate of transfusion and the mortality in severely injured patients: a retrospective multi-centre study.

    Science.gov (United States)

    Jensen, Kai Oliver; Held, Leonhard; Kraus, Andrea; Hildebrand, Frank; Mommsen, Philipp; Mica, Ladislav; Wanner, Guido A; Steiger, Peter; Moos, Rudolf M; Simmen, Hans-Peter; Sprengel, Kai

    2016-10-06

    Although under discussion, induced hypothermia (IH) is an established therapy for patients with cardiac arrest or traumatic brain injuries. The influences on coagulopathy and bleeding tendency in severely injured patients (SIP) with concomitant traumatic brain injury are most widely unclear. Therefore, the aim of this study was to quantify the effect of mild IH in SIP with concomitant severe traumatic brain injuries on transfusion rate and mortality. In this retrospective multi-centre study, SIP from three European level-1 trauma centres with an ISS ≥16 between 2009 and 2011 were included. At hospital A, patients qualified for IH with age ≤70 years and a severe head injury with an abbreviated injury scale (AIS Head ) of ≥3. IH was defined as target core body temperature of 35 °C. Hypothermic patients were matched with two patients, one from hospital B and one from hospital C using age and AIS Head . The effect of IH on the transfusion rate, complications and mortality was quantified with 95 % confidence intervals (CI). Patients not treated with IH in hospital A and those from hospital B and C, who were not matched, were used to adjust the CI for the effect of inter-hospital therapy protocol differences. Mean age of patients in the IH-group (n = 43) was 35.7 years, mean ISS 30 points and sex distribution showed 83.7 % male. Mean age of matched patients in the normotherm-group (n = 86) was 36.7 years, mean ISS 33 points and there were 75.6 % males. For the hypothermic patients, we pointed out an estimate of mean difference for the number of transfused units of packed red blood cells as well as for mortality which does not indicate a decrease in the benefit gained by hypothermia. It is suggested that hypothermic patients tend to a higher rate of lung failure and thromboembolisms. Though tending to an increased rate of complications, there is no evidence for a difference in both; rate of transfusion and mortality in SIP. Mild IH as an option for

  11. Nondestructive investigatons of the depth profile of PZT ferroelectric films

    Czech Academy of Sciences Publication Activity Database

    Deineka, Alexander; Glinchuk, M. D.; Jastrabík, Lubomír; Suchaneck, G.; Gerlach, G.

    2001-01-01

    Roč. 264, - (2001), s. 151-156 ISSN 0015-0193 R&D Projects: GA MŠk LN00A015; GA ČR GA202/00/1425 Institutional research plan: CEZ:AV0Z1010914 Keywords : ferroelectric film * depth profile * interface Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 0.471, year: 2001

  12. Prehospital cardiac arrest survival and neurologic recovery.

    Science.gov (United States)

    Hillis, M; Sinclair, D; Butler, G; Cain, E

    1993-01-01

    Many studies of prehospital defibrillation have been conducted but the effects of airway intervention are unknown and neurologic follow-up has been incomplete. A non-randomized cohort prospective study was conducted to determine the effectiveness of defibrillation in prehospital cardiac arrest. Two ambulance companies in the study area developed a defibrillation protocol and they formed the experimental group. A subgroup of these patients received airway management with an esophageal obturator airway (EOA) or endotracheal intubation (ETT). The control group was composed of patients who suffered a prehospital cardiac arrest and did not receive prehospital defibrillation. All survivors were assessed for residual deficits using the Sickness Impact Profile (SIP) and the Dementia Rating Scale (DRS). A total of 221 patients were studied over a 32-month period. Both the experimental group (N = 161) and the control group (N = 60) were comparable with respect to age, sex distribution, and ambulance response time. Survival to hospital discharge was 2/60 (3.3%) in the control group and 12/161 (6.3%) in the experimental group. This difference is not statistically significant. Survival in the experimental group by airway management technique was basic airway support (3/76 3.9%), EOA (3/67 4.5%), and ETT (6/48 12.5%). The improved effect on survival by ETT management was statistically significant. Survivors had minor differences in memory, work, and recreation as compared to ischemic heart disease patients as measured by the SIP and DRS. No effect of defibrillation was found on survival to hospital discharge. However, endotracheal intubation improved survival in defibrillated patients. Survivors had a good functional outcome.

  13. The cognitive profile of ALS : A systematic review and meta-analysis update

    NARCIS (Netherlands)

    Beeldman, E.; Raaphorst, J.; Klein Twennaar, M.; de Visser, M.; Schmand, B.A.; de Haan, R.J.

    Cognitive impairment is present in approximately 30% of patients with amyotrophic lateral sclerosis (ALS) and, especially when severe, has a negative impact on survival and caregiver burden. Our 2010 meta-analysis of the cognitive profile of ALS showed impairment of fluency, executive function,

  14. The cognitive profile of ALS: a systematic review and meta-analysis update

    NARCIS (Netherlands)

    Beeldman, Emma; Raaphorst, Joost; Klein Twennaar, Michelle; de Visser, Marianne; Schmand, Ben A.; de Haan, Rob J.

    2016-01-01

    Cognitive impairment is present in approximately 30% of patients with amyotrophic lateral sclerosis (ALS) and, especially when severe, has a negative impact on survival and caregiver burden. Our 2010 meta-analysis of the cognitive profile of ALS showed impairment of fluency, executive function,

  15. Shave-off depth profiling: Depth profiling with an absolute depth scale

    International Nuclear Information System (INIS)

    Nojima, M.; Maekawa, A.; Yamamoto, T.; Tomiyasu, B.; Sakamoto, T.; Owari, M.; Nihei, Y.

    2006-01-01

    Shave-off depth profiling provides profiling with an absolute depth scale. This method uses a focused ion beam (FIB) micro-machining process to provide the depth profile. We show that the shave-off depth profile of a particle reflected the spherical shape of the sample and signal intensities had no relationship to the depth. Through the introduction of FIB micro-sampling, the shave-off depth profiling of a dynamic random access memory (DRAM) tip was carried out. The shave-off profile agreed with a blue print from the manufacturing process. Finally, shave-off depth profiling is discussed with respect to resolutions and future directions

  16. The Effect of School Improvement Planning on Student Achievement

    Science.gov (United States)

    Huber, David J.; Conway, James M.

    2015-01-01

    This study evaluated the hypothesis that schools in Connecticut's Alliance Districts (lowest-performing districts) with higher-quality school improvement plans (SIPs) would have higher levels of student achievement. An exploratory research question evaluated whether SIPs predicted achievement of particular subgroups. SIPs were obtained and scored…

  17. Reliability and Validity of a Nepalese Version of the Oral Health Impact Profile for Edentulous Subjects.

    Science.gov (United States)

    Shrestha, Bidhan; Niraula, Surya Raj; Parajuli, Prakash K; Suwal, Pramita; Singh, Raj Kumar

    2018-06-01

    To assess the reliability and to validate the translated Nepalese version of the Oral Health Impact Profile (OHIP-EDENT-N) in Nepalese edentulous subjects. The international guidelines for translation and cross-cultural adaption of OHIP-EDENT were followed, and a Nepalese version of the questionnaire was adapted for this study. Eighty-eight completely edentulous subjects were then selected for the study and completed their responses for the questionnaire. The reliability of the OHIP-EDENT-N was evaluated using internal consistency. Validity was assessed as construct and convergent validity. Construct validity was determined using exploratory factor analysis (EFA). The correlation between OHIP-EDENT-N subscale scores and the global question was investigated to test the convergent validity. Cronbach's alpha for the total score of OHIP-EDENT-N was 0.78. Construct validity was assessed by factor analysis: 70.196% of the variance was accountable to five factors extracted from the factor analysis. Factor loadings above 0.40 were noted for all items. In terms of convergent validity, significant correlations could be established between OHIP-EDENT-N and global questions. This study has been able to establish the reliability and validity of the OHIP-EDENT-N, and OHIP-EDENT-N can be a considered a reliable tool to assess the oral health related quality of life in the Nepalese edentulous population. © 2016 by the American College of Prosthodontists.

  18. Long-Term Impact of Sediment Deposition and Erosion on Water Surface Profiles in the Ner River

    Directory of Open Access Journals (Sweden)

    Tomasz Dysarz

    2017-02-01

    Full Text Available The purpose of the paper is to test forecasting of the sediment transport process, taking into account two main uncertainties involved in sediment transport modeling. These are: the lack of knowledge regarding future flows, and the uncertainty with respect to which sediment transport formula should be chosen for simulations. The river reach chosen for study is the outlet part of the Ner River, located in the central part of Poland. The main characteristic of the river is the presence of an intensive morphodynamic process, increasing flooding frequency. The approach proposed here is based on simulations with a sediment-routing model and assessment of the hydraulic condition changes on the basis of hydrodynamic calculations for the chosen characteristic flows. The data used include Digital Terrain Models (DTMs, cross-section measurements, and hydrological observations from the Dabie gauge station. The sediment and hydrodynamic calculations are performed using program HEC-RAS 5.0. Twenty inflow scenarios are of a 10-year duration and are composed on the basis of historical data. Meyer-Peter and Müller and Engelund-Hansen formulae are applied for the calculation of sediment transport intensity. The methodology presented here seems to be a good tool for the prediction of long-term impacts on water surface profiles caused by sediment deposition and erosion.

  19. Bank Risk Profile, Good Corporate Governance And Company Values in Banking Companies Go Public in Indonesia

    OpenAIRE

    Susi Retna Cahyaningtyas; Elin Erlina Sasanti; Wahidatul Husnaini

    2017-01-01

    The latest Bank Indonesia Regulation No.14/18/PBI/2012 requires bank to have minimum capital of 8%-14% depends on the risk profile of each bank. Therefore, the main objective of this research is to assess whether the total of inherent risk profile of each bank meets the terms of this regulation. In addition, this study aims to examine the impact of inherent risk profile and GCG on the banking company value. The sample in this study is determined by purposive sampling method and resulted in 24...

  20. Influence of gender on the correlation between plasma growth hormone profiles and urinary growth hormone excretion

    DEFF Research Database (Denmark)

    Main, K M; Jansson, C; Skakkebak, N

    1997-01-01

    A lot of interest has been directed towards the measurement of urinary growth hormone (GH) excretion instead of plasma GH profiles or provocation tests. We investigated the factors influencing the relationship between 24- and 3-hour plasma GH profiles and urinary GH excretion in a cohort of 113...... than spontaneous GH peaks. The difference in cross-reactivities of molecular GH forms in polyclonal assays may have an impact on the correlation between plasma and urinary GH. Thus, the diagnostic value of urinary GH measurement as compared to serum GH profiles needs to be further evaluated....

  1. The development of a purification procedure for saxitoxin-induced protein.

    Science.gov (United States)

    Smith, D S; Kitts, D D; Fenske, B; Owen, T G; Shyng, S

    1995-02-01

    A simple economical procedure for purifying saxitoxin-induced protein (SIP) from crude extracts of the small shore crab, Hemigrapsus oregenesis, was developed. (NH4)2SO4 precipitation, chymotrypsin digestion, heat treatment, gel filtration and ion-exchange-chromatography procedures were evaluated in purifying SIP. An enzyme immunoassay was used to determine the SIP yield and relative purity at each step of three procedures, thus permitting an assessment of the conditions required for maximum recovery. Response surface analysis was used in an attempt to determine the optimum temperature and exposure time for the heat treatment. A 20 min incubation at 65 degrees C was confirmed by electrophoretic analysis to be the best combination of time and temperature for achieving both an acceptable yield and purity of SIP. SIP in desalted concentrate was shown to be resistant to chymotrypsin proteolysis; however, this enzyme had deleterious effects on SIP purification at later stages of the procedure. The omission of the chymotrypsin digestion, and the inclusion of gel-filtration chromatography in the final clean-up step, resulted in the purification of SIP comparable with that achieved with affinity chromatography.

  2. Development of radiological profiles for U.S. Department of Energy low-level mixed wastes

    International Nuclear Information System (INIS)

    Wilkins, B.D.; Meshkov, N.K.; Dolak, D.A.; Wang, Y.Y.

    1995-01-01

    Radiological profiles have been developed by Argonne National Laboratory for low-level mixed wastes (LLMWs) that are under the management of the US Department of Energy (DOE). These profiles have been used in the Office of Environmental Management Programmatic Environmental Impact Statement (EM PEIS) to support the analysis of environmental and health risks associated with the various waste management strategies. The radiological characterization of DOE LLMWs is generally inadequate and has made it difficult to develop a site- and waste-stream-dependent radiological profile for LLMWs. On the basis of the operational history of the DOE sites, a simple model was developed to generate site-dependent and waste-stream-independent radiological profiles for LLMWs. This paper briefly discusses the assumptions used in this model and the uncertainties in the results

  3. Study of damaged depth profiles of ion-irradiated PEEK

    Czech Academy of Sciences Publication Activity Database

    Vacík, Jiří; Hnatowicz, Vladimír; Červená, Jarmila; Apel, P. Yu.; Posta, S.; Kobayashi, Y.

    2007-01-01

    Roč. 201, 19-20 (2007), s. 8370-8372 ISSN 0257-8972 R&D Projects: GA MPO(CZ) 1H-PK2/05; GA MŠk 1P04LA213 Institutional research plan: CEZ:AV0Z10480505 Keywords : Oxygen irradiation * Poly-aryl-ether-ether ketone * Thermal neutron depth profiling (TNDP) Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders Impact factor: 1.678, year: 2007

  4. Time to talk about work-hour impact on anesthesiologists: The effects of sleep deprivation on Profile of Mood States and cognitive tasks.

    Science.gov (United States)

    Saadat, Haleh; Bissonnette, Bruno; Tumin, Dmitry; Thung, Arlyne; Rice, Julie; Barry, N'Diris; Tobias, Joseph

    2016-01-01

    A physician's fatigue raises significant concerns regarding personal and patient safety. Effects of sleep deprivation on clinical performance and the quality of patient care are major considerations of today's health care environment. To evaluate the impact of partial sleep deprivation after a 17-h overnight call (3 pm-7 am) on the mood status and cognitive skills of anesthesiologists in an academic clinical hospital setting, as compared to these parameters during regular working hours. Taking circadian rhythm into account, the following measures were assessed in 21 pediatric anesthesiologists at two time points over the course of the study; (i) between 7 and 8 am on a regular non call day, and (ii) between 7 and 8 am after a 17-h in-house call (3 pm-7 am). Six mood states were assessed using the Profile of Mood States. A Total Mood Disturbance (TMD) score was obtained as the sum of all mood scores minus vigor. The total score provides a global estimate of affective state. Simple cognitive tests were similarly administered to assess cognitive skills. A two-tailed paired t-test was used to compare data between regular and post call days. A P sleep deprivation affects the total mood status of anesthesiologists and impacts their cognitive skills. These findings are particularly relevant in a context of increased work expectation, particularly on clinical performance in our modern medical system. Such observations suggest that there may be changes that impact the safety of our patients and the quality of health care that is provided. © 2015 John Wiley & Sons Ltd.

  5. Impact of the Assimilation of Hyperspectral Infrared Retrieved Profiles on Advanced Weather and Research Model Simulations of a Non-Convective Wind Event

    Science.gov (United States)

    Berndt, E. B.; Zavodsky, B. T.; Folmer, M. J.; Jedlovec, G. J.

    2014-01-01

    Non-convective wind events commonly occur with passing extratropical cyclones and have significant societal and economic impacts. Since non-convective winds often occur in the absence of specific phenomena such as a thunderstorm, tornado, or hurricane, the public are less likely to heed high wind warnings and continue daily activities. Thus non-convective wind events result in as many fatalities as straight line thunderstorm winds. One physical explanation for non-convective winds includes tropopause folds. Improved model representation of stratospheric air and associated non-convective wind events could improve non-convective wind forecasts and associated warnings. In recent years, satellite data assimilation has improved skill in forecasting extratropical cyclones; however errors still remain in forecasting the position and strength of extratropical cyclones as well as the tropopause folding process. The goal of this study is to determine the impact of assimilating satellite temperature and moisture retrieved profiles from hyperspectral infrared (IR) sounders (i.e. Atmospheric Infrared Sounder (AIRS), Cross-track Infrared and Microwave Sounding Suite (CrIMSS), and Infrared Atmospheric Sounding Interferometer (IASI)) on the model representation of the tropopause fold and an associated high wind event that impacted the Northeast United States on 09 February 2013. Model simulations using the Advanced Research Weather Research and Forecasting Model (ARW) were conducted on a 12-km grid with cycled data assimilation mimicking the operational North American Model (NAM). The results from the satellite assimilation run are compared to a control experiment (without hyperspectral IR retrievals), 32-km North American Regional Reanalysis (NARR) interpolated to a 12-km grid, and 13-km Rapid Refresh analyses.

  6. New Developments in Developmental Research on Social Information Processing and Antisocial Behavior

    Science.gov (United States)

    Fontaine, Reid Griffith

    2010-01-01

    The Special Section on developmental research on social information processing (SIP) and antisocial behavior is here introduced. Following a brief history of SIP theory, comments on several themes--measurement and assessment, attributional and interpretational style, response evaluation and decision, and the relation between emotion and SIP--that…

  7. Social Information Processing as a Mediator between Cognitive Schemas and Aggressive Behavior in Adolescents

    Science.gov (United States)

    Calvete, Esther; Orue, Izaskun

    2012-01-01

    This longitudinal investigation assessed whether cognitive schemas of justification of violence, mistrust, and narcissism predicted social information processing (SIP), and SIP in turn predicted aggressive behavior in adolescents. A total of 650 adolescents completed measures of cognitive schemas at Time 1, SIP in ambiguous social scenarios at…

  8. Profile of cognitive problems in schizophrenia and implications for vocational functioning.

    Science.gov (United States)

    Tan, Bhing-Leet

    2009-08-01

    This literature review attempts to profile specific areas of cognition that have shown unique and consistent evidence of dysfunction among people with schizophrenia. In addition, their impact on vocational functioning is illustrated, so as to highlight the importance of managing these cognitive difficulties in vocational rehabilitation. Literature search was carried out on seven key cognitive domains identified by the National Institute of Mental Health in the USA. Their impact on vocational function was also reviewed. It is found that attention, declarative and working memory, reasoning, problem-solving and social cognition are areas of impairment that have great impact on vocational functioning. Attention and memory problems affect learning of new work tasks. Executive function is particularly crucial in determining supported and open employment outcomes, as executive dysfunction cannot be easily compensated. Lastly, social cognition plays a major role in determining the success of workplace social exchanges. Occupational therapists need to have a good understanding of the profile of cognitive problems among people with schizophrenia, in order to tailor our intervention according to their cognitive strengths and difficulties. Several cognitive remediation strategies and programs have been designed specifically for people with mental illness. Equipping ourselves with skills in conducting such programs will augment our expertise in vocational rehabilitation.

  9. Antenatal magnesium sulfate and spontaneous intestinal perforation in infants less than 25 weeks gestation.

    Science.gov (United States)

    Rattray, B N; Kraus, D M; Drinker, L R; Goldberg, R N; Tanaka, D T; Cotten, C M

    2014-11-01

    Evaluate spontaneous intestinal perforation (SIP)/death among extremely low birthweight (ELBW) infants before, during and after initiation of an antenatal magnesium for neuroprotection protocol (MgPro). We tested associations between SIP/death and magnesium exposure, gestational age (GA) and interactions with GA and magnesium exposure in a cohort of inborn ELBW infants before, during and after MgPro. One hundred and fifty-five ELBW infants were included, 81 before, 23 during and 51 after MgPro. ELBW infants (78.3%) were exposed to Mg during MgPro compared with 50.6% and 60.8% before and after, respectively. Incidence of SIP on protocol was 30.4% vs 12.9% off protocol (P=0.03). GA was strongly associated with SIP (PSIP/death regardless of epoch (odds ratio 9.3 (1.04-104.6)), but increased SIP/death was limited to those SIP and death risk among infants with the lowest birthweights. Validation of this observation in larger populations is warranted.

  10. Searching mixed DNA profiles directly against profile databases.

    Science.gov (United States)

    Bright, Jo-Anne; Taylor, Duncan; Curran, James; Buckleton, John

    2014-03-01

    DNA databases have revolutionised forensic science. They are a powerful investigative tool as they have the potential to identify persons of interest in criminal investigations. Routinely, a DNA profile generated from a crime sample could only be searched for in a database of individuals if the stain was from single contributor (single source) or if a contributor could unambiguously be determined from a mixed DNA profile. This meant that a significant number of samples were unsuitable for database searching. The advent of continuous methods for the interpretation of DNA profiles offers an advanced way to draw inferential power from the considerable investment made in DNA databases. Using these methods, each profile on the database may be considered a possible contributor to a mixture and a likelihood ratio (LR) can be formed. Those profiles which produce a sufficiently large LR can serve as an investigative lead. In this paper empirical studies are described to determine what constitutes a large LR. We investigate the effect on a database search of complex mixed DNA profiles with contributors in equal proportions with dropout as a consideration, and also the effect of an incorrect assignment of the number of contributors to a profile. In addition, we give, as a demonstration of the method, the results using two crime samples that were previously unsuitable for database comparison. We show that effective management of the selection of samples for searching and the interpretation of the output can be highly informative. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  11. Density profiles of supernova matter and determination of neutrino parameters

    Science.gov (United States)

    Chiu, Shao-Hsuan

    2007-08-01

    The flavor conversion of supernova neutrinos can lead to observable signatures related to the unknown neutrino parameters. As one of the determinants in dictating the efficiency of resonant flavor conversion, the local density profile near the Mikheyev-Smirnov-Wolfenstein (MSW) resonance in a supernova environment is, however, not so well understood. In this analysis, variable power-law functions are adopted to represent the independent local density profiles near the locations of resonance. It is shown that the uncertain matter density profile in a supernova, the possible neutrino mass hierarchies, and the undetermined 1-3 mixing angle would result in six distinct scenarios in terms of the survival probabilities of νe and ν¯e. The feasibility of probing the undetermined neutrino mass hierarchy and the 1-3 mixing angle with the supernova neutrinos is then examined using several proposed experimental observables. Given the incomplete knowledge of the supernova matter profile, the analysis is further expanded to incorporate the Earth matter effect. The possible impact due to the choice of models, which differ in the average energy and in the luminosity of neutrinos, is also addressed in the analysis.

  12. Development of chemical profiles for U.S. Department of Energy low-level mixed wastes

    International Nuclear Information System (INIS)

    Wang, Y.Y.; Wilkins, B.D.; Meshkov, N.K.; Dolak, D.A.

    1995-01-01

    Chemical and radiological profiles of waste streams from US Department of Energy (DOE) low-level mixed wastes (LLMWs) have been developed by Argonne National Laboratory (ANL) to provide technical support information for evaluating waste management alternatives in the Office of Environmental Management Programmatic Environmental Impact Statement (EM PEIS). The chemical profiles were developed for LLMW generated from both Waste Management (WM) operations and from Environmental Restoration (ER) activities at DOE facilities. Information summarized in the 1994 DOE Mixed Waste Inventory Report (MWIR-2), the Pacific Northwest Laboratory (PNL) Automated Remedial Assessment Methodology (ARAM), and associated PNL supporting data on ER secondary waste streams that will be treated in WM treatment facilities were used as the sources for developing chemical profiles. The methodology for developing the LLMW chemical profiles is discussed, and the chemical profiles developed from data for contact-handled (CH) non-alpha LLMW are presented in this paper. The hazardous chemical composition of remote-handled (RH) LLMW and alpha LLMW follow the chemical profiles developed for CH non-alpha LLMW

  13. Impact of oral rehabilitation on patients with head and neck cancer: A study using the Liverpool Oral Rehabilitation Questionnaire and the Oral Health Impact Profile-14.

    Science.gov (United States)

    Dholam, Kanchan P; Dugad, Jinesh A; Sadashiva, Karthik M

    2017-04-01

    The treatment of oral cancers affects oral functions and quality of life (QOL). Dental rehabilitation is a major step toward enhancing quality of life after controlling the disease. The effects of the disease, treatment, and rehabilitation need to be evaluated to assess oral health-related QOL. The Liverpool Oral Rehabilitation Questionnaire version 3 (LORQv3) and Oral Health Impact Profile-14 (OHIP-14) are specific assessment questionnaires of oral rehabilitation. The purpose of this study was to assess the impact of oral rehabilitation on patients with head and neck cancer by using the LORQv3 and OHIP-14 questionnaires and to discover and document specific patient-derived problems related to the issues of oral rehabilitation. The LORQv3 and OHIP-14 questionnaires were administered to 60 participants with oral cancer, who were in need of oral rehabilitation. They were asked to rate their dental problems on a Likert scale before fabrication of their prostheses (baseline) and at the 3-month follow-up visit after prosthetic rehabilitation. Paired comparison was done using the Wilcoxon signed rank test according to the distribution, and Cronbach alpha was used to assess internal consistency. Subscale scores were determined by mean value (α=.05). For the LORQv3 questionnaire, a 10% to 27% improvement was found in the domain of oral function, and a 20% improvement in orofacial appearance, with improvement in patient satisfaction with the prosthesis. Using the OHIP-14 questionnaire, a 45% to 67% improvement was generally seen in all domains. After assessment using the LORQv3 and OHIP-14 questionnaires, prosthetic rehabilitation was seen to contribute to the betterment of patients with head and neck cancer. Copyright © 2016 Editorial Council for the Journal of Prosthetic Dentistry. Published by Elsevier Inc. All rights reserved.

  14. The impact of freeze-drying infant fecal samples on measures of their bacterial community profiles and milk-derived oligosaccharide content

    Directory of Open Access Journals (Sweden)

    Zachery T. Lewis

    2016-01-01

    Full Text Available Infant fecal samples are commonly studied to investigate the impacts of breastfeeding on the development of the microbiota and subsequent health effects. Comparisons of infants living in different geographic regions and environmental contexts are needed to aid our understanding of evolutionarily-selected milk adaptations. However, the preservation of fecal samples from individuals in remote locales until they can be processed can be a challenge. Freeze-drying (lyophilization offers a cost-effective way to preserve some biological samples for transport and analysis at a later date. Currently, it is unknown what, if any, biases are introduced into various analyses by the freeze-drying process. Here, we investigated how freeze-drying affected analysis of two relevant and intertwined aspects of infant fecal samples, marker gene amplicon sequencing of the bacterial community and the fecal oligosaccharide profile (undigested human milk oligosaccharides. No differences were discovered between the fecal oligosaccharide profiles of wet and freeze-dried samples. The marker gene sequencing data showed an increase in proportional representation of Bacteriodes and a decrease in detection of bifidobacteria and members of class Bacilli after freeze-drying. This sample treatment bias may possibly be related to the cell morphology of these different taxa (Gram status. However, these effects did not overwhelm the natural variation among individuals, as the community data still strongly grouped by subject and not by freeze-drying status. We also found that compensating for sample concentration during freeze-drying, while not necessary, was also not detrimental. Freeze-drying may therefore be an acceptable method of sample preservation and mass reduction for some studies of microbial ecology and milk glycan analysis.

  15. Associating co-authorship patterns with publications in high-impact journals.

    Science.gov (United States)

    Bales, Michael E; Dine, Daniel C; Merrill, Jacqueline A; Johnson, Stephen B; Bakken, Suzanne; Weng, Chunhua

    2014-12-01

    To develop a method for investigating co-authorship patterns and author team characteristics associated with the publications in high-impact journals through the integration of public MEDLINE data and institutional scientific profile data. For all current researchers at Columbia University Medical Center, we extracted their publications from MEDLINE authored between years 2007 and 2011 and associated journal impact factors, along with author academic ranks and departmental affiliations obtained from Columbia University Scientific Profiles (CUSP). Chi-square tests were performed on co-authorship patterns, with Bonferroni correction for multiple comparisons, to identify team composition characteristics associated with publication impact factors. We also developed co-authorship networks for the 25 most prolific departments between years 2002 and 2011 and counted the internal and external authors, inter-connectivity, and centrality of each department. Papers with at least one author from a basic science department are significantly more likely to appear in high-impact journals than papers authored by those from clinical departments alone. Inclusion of at least one professor on the author list is strongly associated with publication in high-impact journals, as is inclusion of at least one research scientist. Departmental and disciplinary differences in the ratios of within- to outside-department collaboration and overall network cohesion are also observed. Enrichment of co-authorship patterns with author scientific profiles helps uncover associations between author team characteristics and appearance in high-impact journals. These results may offer implications for mentoring junior biomedical researchers to publish on high-impact journals, as well as for evaluating academic progress across disciplines in modern academic medical centers. Copyright © 2014 Elsevier Inc. All rights reserved.

  16. 76 FR 41424 - Finding of Substantial Inadequacy of Implementation Plan; Call for Iowa State Implementation Plan...

    Science.gov (United States)

    2011-07-14

    ... modeling requirement for this SIP call should allow for the use of the modeling protocol developed by Iowa... is making a finding that the Iowa State Implementation Plan (SIP) is substantially inadequate to... ) in Muscatine County, Iowa. The specific SIP deficiencies needing revision are described below. EPA is...

  17. Error Correction of Measured Unstructured Road Profiles Based on Accelerometer and Gyroscope Data

    Directory of Open Access Journals (Sweden)

    Jinhua Han

    2017-01-01

    Full Text Available This paper describes a noncontact acquisition system composed of several time synchronized laser height sensors, accelerometers, gyroscope, and so forth in order to collect the road profiles of vehicle riding on the unstructured roads. A method of correcting road profiles based on the accelerometer and gyroscope data is proposed to eliminate the adverse impacts of vehicle vibration and attitudes change. Because the power spectral density (PSD of gyro attitudes concentrates in the low frequency band, a method called frequency division is presented to divide the road profiles into two parts: high frequency part and low frequency part. The vibration error of road profiles is corrected by displacement data obtained through two times integration of measured acceleration data. After building the mathematical model between gyro attitudes and road profiles, the gyro attitudes signals are separated from low frequency road profile by the method of sliding block overlap based on correlation analysis. The accuracy and limitations of the system have been analyzed, and its validity has been verified by implementing the system on wheeled equipment for road profiles’ measuring of vehicle testing ground. The paper offers an accurate and practical approach to obtaining unstructured road profiles for road simulation test.

  18. Three-dimensional impact kinetics with foot-strike manipulations during running

    OpenAIRE

    Andrew D. Nordin; Janet S. Dufek; John A. Mercer

    2017-01-01

    Background: Lack of an observable vertical impact peak in fore/mid-foot running has been suggested as a means of reducing lower extremity impact forces, although it is unclear if impact characteristics exist in other axes. The purpose of the investigation was to compare three-dimensional (3D) impact kinetics among foot-strike conditions in over-ground running using instantaneous loading rate–time profiles. Methods: Impact characteristics were assessed by identifying peak loading rates in e...

  19. Profiles

    International Nuclear Information System (INIS)

    2004-01-01

    Profiles is a synthetic overview of more than 100 national energy markets in the world, providing insightful facts and key energy statistics. A Profile is structured around 6 main items and completed by key statistics: Ministries, public agencies, energy policy are concerned; main companies in the oil, gas, electricity and coal sectors, status, shareholders; reserve, production, imports and exports, electricity and refining capacities; deregulation of prices, subsidies, taxes; consumption trends by sector, energy market shares; main energy projects, production and consumption prospects. Statistical Profiles are present in about 3 pages the main data and indicators on oil, gas, coal and electricity. (A.L.B.)

  20. How IMS Enables Converged Services for Cable and 3G Technologies: A Survey

    Directory of Open Access Journals (Sweden)

    Noël Crespi

    2008-04-01

    Full Text Available The IP multimedia subsystem (IMS is a service control overlay standardized by the 3GPP. The IMS is based on session initiation protocol (SIP to establish, modify, and terminate the sessions. It provides a clean separation between services, signaling, and media with the potential to enable control and management of services over multiple transport technologies. In the scope of fixed-mobile convergence, this paper is dedicated to presenting a review of how cable networks can be integrated into IMS technology to achieve 3G-cable horizontal convergence. Cable networks, as one of the major fixed broadband access technologies with PacketCable architecture, are able to provide broadband internet access and VoIP in addition to cable TV. In this article, we review the evolution in PacketCable architecture to take up IMS. In this way, we consider the standardization and research activities to address this integration. We review some important challenges such as SIP protocol compatibility, defining unique user profile, required enhancement in authentication process, QoS and charging system.