Comparison of FDG-PET and IMP-SPECT in patients with dementia with Lewy bodies

International Nuclear Information System (INIS)

Ishii, Kazunari; Hosaka, Kayo; Mori, Tetsuya; Mori, Etsuro

2004-01-01

To investigate regional differences in cerebral glucose metabolism and blood flow of dementia with Lewy bodies (DLB), we studied 7 subjects with DLB and 20 normal controls using F-18 fluorodeoxyglucose (FDG) and positron emission tomography (PET) and then examined the same 7 subjects and 20 other normal controls with I-123 iodoamphetamine (IMP) and single photon emission computed tomography (SPECT). The anatomically standardized images were produced with NEUROSTAT and the regional relative metabolic and perfusional values were calculated. The mean reduction ratios of FDG uptake in the DLB group relative to the mean normal controls in the parietal lobe and occipital lobe were 0.72 and 0.83, respectively, while the corresponding mean reduction ratios of IMP uptake were 0.81 and 0.88, respectively. In the DLB group, parietal FDG uptake was significantly lower than parietal IMP uptake (p<0.05), occipital FDG uptake was significantly lower than occipital IMP uptake (p<0.05), and parietal IMP uptake was significantly lower than occipital IMP uptake (p<0.01), but there was no difference between parietal and occipital FDG uptake. Our findings suggest that parietal metabolism and perfusion are severely affected in DLB patients, though the occipital metabolic and perfusional reduction is thought to be a feature of DLB. FDG-PET is thought to be superior to IMP-SPECT in detecting functional changes in the DLB brain. (author)

Characteristics and management of Enterobacteriaceae harboring IMP-4 or IMP-8 carbapenemase in a tertiary hospital.

Science.gov (United States)

Pang, Feng; Jia, Xiu-Qin; Song, Zhen-Zhu; Li, Yan-Hua; Wang, Bin; Zhao, Qi-Gang; Wang, Chuan-Xin; Zhang, Yi; Wang, Le-Xin

2016-03-01

The emergence of Enterobacteriaceae harboring IMP-4 or IMP-8 carbapenemases is rare. We report an occurrence of Enterobacteriaceae harboring IMP-4 or IMP-8 carbapenemases in a Chinese tertiary care hospital from November 2010 to December 2012. The clinical characteristics of 30 patients were described. The genetic relationship of isolates was determined by pulsed-field gel electrophoresis (PFGE). Carbapenemases were detected by modified Hodge test (MHT) and polymerase chain reactions (PCRs). Amplicons were sequenced and blasted to determine the genotype. Most infected patients were from intensive care unit and had complex and serious underlying illnesses requiring mechanical ventilation. PFGE revealed that Klebsiella pneumoniae showed two major PFGE types. Two Klebsiella oxytoca had an indistinguishable PFGE pattern, while four Enterobacter cloacae were different strains. The sequencing studies showed Enterobacteriaceae harboring IMP-4 or IMP-8 carbapenemase in the 23 infected patients. The majority of patients had infections with the carbapenemase-producing Enterobacteriaceae (CPE) strain, most were successfully treated with a range of antibiotics and discharged. It is important to maintain a high index of suspicion to screen for carbapenemase-producing Enterobacteriaceae strains. Rapid identification of these strains and implementation of stringent procedures are the key to prevent major outbreaks in a hospital setting.

N-isopropyl I-123 p-iodoamphetamine (IMP) brain SPECT in dementia

International Nuclear Information System (INIS)

Momose, Toshimitsu; Kosaka, Noboru; Nishikawa, Junichi; Yoshikawa, Kohki; Ohtake, Tohru; Watanabe, Toshiaki; Iwata, Makoto; Shimizu, Teruo; Iio, Masahiro

1988-01-01

Six patients of Alzheimer's disease (AD), two patients of Pick disease (PD) and two patients of Creutzfeldt-Jakob disease (CJD) were studied with N-Isopropyl I-123 p-Iodoamphetamine (IMP) with SPECT. The pattern of IMP uptake in these demented groups were compared with that in five agematched normal controls and correlated with MRI and XCT. In all AD cases, SPECT revealed focal reduction of IMP uptake in frontal (6/6), parietal (6/6) and temporal (6/6) cortex, although MRI and XCT were normal. In both PD case, SPECT showed focal reduction of IMP uptake in frontal (1/2) and temporal (2/2) cortex with moderate labor atrophy on MRI and XCT. In both CJD case, SPECT showed diffuse reduction of IMP uptake in cerebral cortex in spite of no abnormality on MRI and XCT. These findings suggest that SPECT can detect earlier diseased process of AD and CJD than MRI or XCT and that SPECT may be helpful for the differential diagnosis of non-vascular dementia. (author)

N-isopropyl I-123 p-iodoamphetamine (IMP) brain SPECT in dementia

Energy Technology Data Exchange (ETDEWEB)

Momose, Toshimitsu; Kosaka, Noboru; Nishikawa, Junichi; Yoshikawa, Kohki; Ohtake, Tohru; Watanabe, Toshiaki; Iwata, Makoto; Shimizu, Teruo; Iio, Masahiro

1988-12-01

Six patients of Alzheimer's disease (AD), two patients of Pick disease (PD) and two patients of Creutzfeldt-Jakob disease (CJD) were studied with N-Isopropyl I-123 p-Iodoamphetamine (IMP) with SPECT. The pattern of IMP uptake in these demented groups were compared with that in five agematched normal controls and correlated with MRI and XCT. In all AD cases, SPECT revealed focal reduction of IMP uptake in frontal (6/6), parietal (6/6) and temporal (6/6) cortex, although MRI and XCT were normal. In both PD case, SPECT showed focal reduction of IMP uptake in frontal (1/2) and temporal (2/2) cortex with moderate labor atrophy on MRI and XCT. In both CJD case, SPECT showed diffuse reduction of IMP uptake in cerebral cortex in spite of no abnormality on MRI and XCT. These findings suggest that SPECT can detect earlier diseased process of AD and CJD than MRI or XCT and that SPECT may be helpful for the differential diagnosis of non-vascular dementia.

RNA-binding IMPs promote cell adhesion and invadopodia formation

DEFF Research Database (Denmark)

Vikesaa, Jonas; Hansen, Thomas V O; Jønson, Lars

2006-01-01

Oncofetal RNA-binding IMPs have been implicated in mRNA localization, nuclear export, turnover and translational control. To depict the cellular actions of IMPs, we performed a loss-of-function analysis, which showed that IMPs are necessary for proper cell adhesion, cytoplasmic spreading and inva......Oncofetal RNA-binding IMPs have been implicated in mRNA localization, nuclear export, turnover and translational control. To depict the cellular actions of IMPs, we performed a loss-of-function analysis, which showed that IMPs are necessary for proper cell adhesion, cytoplasmic spreading...... and invadopodia formation. Loss of IMPs was associated with a coordinate downregulation of mRNAs encoding extracellular matrix and adhesion proteins. The transcripts were present in IMP RNP granules, implying that IMPs were directly involved in the post-transcriptional control of the transcripts. In particular......-mediated invadopodia formation. Taken together, our results indicate that RNA-binding proteins exert profound effects on cellular adhesion and invasion during development and cancer formation....

N-isopropyl I-123 p-iodoamphetamine (IMP) brain SPECT in Alzheimer's disease

Energy Technology Data Exchange (ETDEWEB)

Momose, Toshimitsu; Nishikawa, Junichi; Kosaka, Noboru; Ohtake, Tohru; Watanabe, Toshiaki; Yoshikawa, Kohki; Iio, Masahiro [Tokyo Univ. (Japan). Faculty of Medicine

1989-09-01

Eighteen patients with Alzheimer's disease (AD), 5 patients with Pick disease (PD), 6 patients with other types of degenerative dementia (O) and 12 age-matched normal control subjects (N) were studied using N-isopropyl p-(I-123)iodoamphetamine (I-123 IMP) with SPECT. Regional to cerebellar activity (R/CE) ratio and frontal to parietal (F/R) activity ratio were evaluated in each case. I-123 IMP-SPECT revealed focal abnormality in all cases in AD, PD, O group, while XCT and/or MRI were normal or showed cerebral atrophy without focal abnormal density or intensity. In AD group, R/CE ratio in all the regions except for bilateral Rolandic area and left primary visual cortex were significantly lower (p<0.05 or p<0.01) than that in N group, and F/P ratio were significantly higher (p<0.01) than that in P and O group. In conclusion, I-123 IMP-SPECT is useful to detect focal perfusion abnormality in dementia and may be of value in differentiating Alzheimer's disease from dementia of non-Alzheimer type. (author).

N-isopropyl I-123 p-iodoamphetamine (IMP) brain SPECT in Alzheimer's disease

International Nuclear Information System (INIS)

Momose, Toshimitsu; Nishikawa, Junichi; Kosaka, Noboru; Ohtake, Tohru; Watanabe, Toshiaki; Yoshikawa, Kohki; Iio, Masahiro

1989-01-01

Eighteen patients with Alzheimer's disease (AD), 5 patients with Pick disease (PD), 6 patients with other types of degenerative dementia (O) and 12 age-matched normal control subjects (N) were studied using N-isopropyl p-[I-123]iodoamphetamine (I-123 IMP) with SPECT. Regional to cerebellar activity (R/CE) ratio and frontal to parietal (F/R) activity ratio were evaluated in each case. I-123 IMP-SPECT revealed focal abnormality in all cases in AD, PD, O group, while XCT and/or MRI were normal or showed cerebral atrophy without focal abnormal density or intensity. In AD group, R/CE ratio in all the regions except for bilateral Rolandic area and left primary visual cortex were significantly lower (p<0.05 or p<0.01) than that in N group, and F/P ratio were significantly higher (p<0.01) than that in P and O group. In conclusion, I-123 IMP-SPECT is useful to detect focal perfusion abnormality in dementia and may be of value in differentiating Alzheimer's disease from dementia of non-Alzheimer type. (author)

A clinical study of auditory hallucination by single photon emission computed tomography (SPECT) using N-isopropyl-p-[123I] iodoamphetamine (IMP)

International Nuclear Information System (INIS)

Gyobu, Tsuyoshi; Inao, Gyoshun; Ii, Masayasu; Matsuda, Hiroshi; Hisada, Kinichi.

1988-01-01

SPECT images with N-isopropyl-p-I-123 iodoamphetamine (IMP) were reviewed in 24 right-handed patients with hallucination (H Group), comprising schizophrenic disorder (20), alcohol hallucinosis (2), epileptic hallucinosis (one), and organic mental disorder (one), and 50 subjects without hallucination (non-H Group), consisting of 39 patients with mental or organic central nervous system disorder and 11 healthy volunteers. Early SPECT images showed an increased uptake of IMP in the auditory area and angular gyrus in 23 patients of H Group and 3 persons of non-H Group. A similar uptake of IMP was seen on delayed SPECT images in 12 patients of H Group and 4 patients with a history of hallucination of non-H Group. There were no SPECT findings specific to diseases. For schizophrenic patients, increased and decreased uptakes of IMP were seen in the striatolimbic region and in the bilateral frontal lobes, respectively, irrespective of hallucination. Factors contributing to increased uptake of IMP are discussed. (Namekawa, K.) 84 refs

ISEE/IMP Observations of simultaneous upstream ion events

International Nuclear Information System (INIS)

Mitchel, D.G.; Roelof, E.C.; Sanderson, T.R.; Reinhard, R.; Wenzel, K.

1983-01-01

Propagation of upstream energetic (50--200 keV) ions is analyzed in sixteen events observed simulataneously by solid state detectors on ISEE 3 at approx.200 R/sub E/ and on IMP 8 at approx.35 R/sub E/ from the earth. Conclusions are based on comparisons of the pitch angle distributions observed at the two spacecraft and transformed into the solar wind frame. They are beamlike at ISEE 3 and are confined to the outward hemisphere. When IMP 8 is furtherest from the bow shock, they are also usually beamlike, or hemispheric. However, when IMP 8 is closer to the bow shock, pancakelike distributions are observed. This systematic variation in the IMP 8 pitch angle distributions delimits a scattering region l< or approx. =14 R/sub E/ upstream of the earth's bow shock (l measured along the interplanetary magnetic field) that dominates ion propagation, influences the global distribution of fluxes in the foreshock, and may play a role in acceleration of the ions. When IMP 8 is beyond lapprox.15 R/sub E/, the propagation appears to be essentially scatter-free between IMP 8 and ISEE 3; this is deduced from the absence of earthward fluxes at IMP 8 as well as the tendency for the spin-averaged fluxes to be comparable at the two spacecraft

Anatomically standardized statistical mapping of 123I-IMP SPECT in brain tumors

International Nuclear Information System (INIS)

Shibata, Yasushi; Akimoto, Manabu; Matsushita, Akira; Yamamoto, Tetsuya; Takano, Shingo; Matsumura, Akira

2010-01-01

123 I-iodoamphetamine Single Photon Emission Computed Tomography (IMP SPECT) is used to evaluate cerebral blood flow. However, application of IMP SPECT to patients with brain tumors has been rarely reported. Primary central nervous system lymphoma (PCNSL) is a rare tumor that shows delayed IMP uptake. The relatively low spatial resolution of SPECT is a clinical problem in diagnosing brain tumors. We examined anatomically standardized statistical mapping of IMP SPECT in patients with brain lesions. This study included 49 IMP SPECT images for 49 patients with brain lesions: 20 PCNSL, 1 Burkitt's lymphoma, 14 glioma, 4 other tumor, 7 inflammatory disease and 3 without any pathological diagnosis but a clinical diagnosis of PCNSL. After intravenous injection of 222 MBq of 123 I-IMP, early (15 minutes) and delayed (4 hours) images were acquired using a multi-detector SPECT machine. All SPECT data were transferred to a newly developed software program iNeurostat+ (Nihon Medi-physics). SPECT data were anatomically standardized on normal brain images. Regions of increased uptake of IMP were statistically mapped on the tomographic images of normal brain. Eighteen patients showed high uptake in the delayed IMP SPECT images (16 PCNSL, 2 unknown). Other tumor or diseases did not show high uptake of delayed IMP SPECT, so there were no false positives. Four patients with pathologically proven PCNSL showed no uptake in original IMP SPECT. These tumors were too small to detect in IMP SPECT. However, statistical mapping revealed IMP uptake in 18 of 20 pathologically verified PCNSL patients. A heterogeneous IMP uptake was seen in homogenous tumors in MRI. For patients with a hot IMP uptake, statistical mapping showed clearer uptake. IMP SPECT is a sensitive test to diagnose of PCNSL, although it produced false negative results for small posterior fossa tumor. Anatomically standardized statistical mapping is therefore considered to be a useful method for improving the diagnostic

The group study of diagnostic efficacy of cerebro-vascular disease by I-123 IMP SPECT images obtained with ring type SPECT scanner

International Nuclear Information System (INIS)

Machida, Kikuo; Honda, Norinari; Matsumoto, Toru

1991-01-01

We performed two image reading experiments in order to investigate the diagnostic capability of I-123 IMP SPECT obtained by the ring type SPECT scanner in cerebro-vascular disease. Fourteen physicians diagnosed SPECT images of 55 cases with reference to clinical neurological information, first without brain XCT images and second with XCT images. Each physician detected perfusion defects and redistributions of I-123 IMP and assigned a confidence level of abnormality for these SPECT findings by means of five rating method. From results obtained by ROC analysis, we concluded as follows. (1) Generally, I-123 IMP SPECT is a stable diagnostic modality in the diagnosis of cerebro-vascular disease and the image reading of XCT had no effects on the diagnosis of SPECT on the whole of physician. (2) However, there were unnegligible differences among individuals in the detectability of findings and the effect of XCT image reading. (3) Detectability of redistribution of I-123 IMP was lower than that of perfusion defect and inter-observer variation in the diagnostic performance for redistribution was larger than that of perfusion defect. The results suggest that it is necessary to standardize diagnostic criteria among physicians for redistribution of I-123 IMP. (author)

The effect of aging and smoking on N-isopropyl-p-[123I]iodoamphetamine (123I-IMP) accumulation in the human lung

International Nuclear Information System (INIS)

Hara, Masafumi; Tomiguchi, Seiji; Kojima, Akihiro; Nakashima, Rumi; Ooyama, Youichi; Takahashi, Mutsumasa; Matsumoto, Masanori.

1994-01-01

123 I-IMP clearance on dynamic lung scintigraphy was studied by two exponential compartments analysis in order to evaluate the effects of aging and smoking on the pulmonary function. Twenty-four patients (14 smokers and 10 non-smokers), referred for 123 I-IMP brain perfusion study, underwent lung dynamic scintigraphy for 42 min immediately after 123 I-IMP injection. In the non-smoking group 123 I-IMP lung clearance was delayed with aging. A significant correlation was found between aging and clearance rate in the lung. There was also a significant difference in the clearance rates between smoker and non-smoker groups. These findings suggest that smoking and aging affect the pulmonary function. (author)

[Expression of IMP3 in osteosarcoma and its clinical significance].

Science.gov (United States)

Li, Kang-hua; Huang, Yue-ping; Zhang, Jun; Li, Guo-jun; Li, Si-hong

2009-05-01

To analyze the expressional variability of IMP3 between osteosarcoma and osteochondroma and explore its clinical significance. Paraffin sections from 68 patients with osteosarcoma and 20 patients with osteochondroma were examined for the expression of IMP3 by SP immunohistochemistry. The negative, weak positive, moderate positive and strong positive expression rates of IMP3 in 68 patients with osteosarcoma were 4.41% (3/68), 22.06% (15/68), 22.74% (19/68), 45.59% (31/68), respectively, which were significantly higher than those in 20 cases of osteochondroma tissues (P<0.01). The positive expression of IMP3 in osteosarcoma was negative correlation with the 3-year survival rate of osteosarcoma patients after the operation (P<0.01). The results suggest that IMP3 plays important roles in the tumorigenesis, progress and prognosis of osteosarcoma, and the expression of IMP3 may be an important feature of osteosarcoma.

I-123 IMP SPECT in Parkinson's disease; In relation to the presence or absence of dementia

Energy Technology Data Exchange (ETDEWEB)

Kawabata, Keita; Tachibana, Kyudai; Sugita, Minoru [Hyogo Medical Coll., Nishinomiya (Japan)

1990-12-01

To examine semiquantitatively regional cerebral blood flow, SPECT with N-isopropyl-p-(I-123)iodoamphetamine (I-123 IMP) was undertaken in 17 patients with Parkinson's disease. Seven patients with Alzheimer's disease and 9 senile control subjects were also imaged for comparison. Both the Parkinson's disease group and the Alzheimer's disease group had a decreased uptake of I-123 IMP in the frontal lobe, in comparison with the control group. A remarkably decreased uptake was seen in the lateral and parietal lobes in the group of Parkinson's disease associated with dementia, as well as in the Alzheimer's disease group. A significantly decreased uptake was observed in the frontal lobe, lateral lobe, thalamus, and basal ganglia in the Parkinson's disease group, irrespective of the presence or absence of dementia. For Parkinson's disease associated with dementia, there was much more significant decrease in I-123 IMP uptake. The pattern of regional cerebral blood flow in the Alzheimer's disease group was analogous to that in the Parkinson's disease group associated with dementia. This supports the hypothesis that Alzheimer's disease may be somewhat involved in the occurrence of dementia for Parkinson's disease. (N.K.).

Stable Isotope Group 1984 progress report

International Nuclear Information System (INIS)

Lyon, G.L.

1985-04-01

The work of the group in 1984 is described and includes studies in isotope geology, isotope hydrology, geochronology, isotope biology and mass spectrometer instrumentation. Geothermal studies have decreased compared to other years, but major data summaries were made for Wairakei and Ngawha. The hydrology of Whakarewarewa and Rotorua is being elucidated using water isotopes. Models of the subsurface flows at Kawerau and Ngawha are being made to relate fluid to mineral isotope compositions. A study of the δ 13 C and δ 34 S compositions of New Zealand oils has been started. Groups of oils of related origin are being defined, and compositions will be compared with those of potential source rocks. A method was developed for isotope analysis of sulphur in rocks. The isotopic composition of water is being used to identify and characterise groundwater aquifers in the Wairarapa and at Poverty Bay. Stable carbon isotopes have been used to identify food sources for invertebrates, and to show biochemical pathways in lactation by cows. The geochronology group is involved in major studies in Antarctica, using U-Pb, Rb-Sr and K-Ar methods. Rocks from North Victoria Land, Marie Byrd Land and the USARP mountains are being compared with possible correlatives in New Zealand and Argentina. Strontium isotope data is being applied to the origin of magmas in several regions of New Zealand. The K-Ar data is being stored on computer files. Fission track measurements are being applied to unravel uplift histories in Westland and Taranaki

Analysis and assessment for the intrapulmonary kinetics of N-isopropyl-I-123-p-iodoamphetamine (IMP) in diffuse respiratory diseases

Energy Technology Data Exchange (ETDEWEB)

Fujishima, Seitaro (Keio Univ., Tokyo (Japan). School of Medicine)

1992-01-01

We investigated intrapulmonary kinetics of N-isopropyl-I-123-p-iodoamphetamine (IMP) in patients with diffuse respiratory diseases. Subjects studied were 4 healthy nonsmoking controls (age{>=}40), 3 young healthy nonsmokers (age<40), 4 healthy smokers, 8 patients with idiopathic pulmonary fibrosis (IPF), 2 with sarcoidosis, and 4 with chronic pulmonary emphysema (CPE). All studies were performed after obtaining informed consent. Ages were matched among the groups except the group of young healthy nonsmokers. We calculated the lung initial extraction fraction (E value) of IMP using Tc-99m human serum albumin as an intravascular reference tracer with deconvolution method. We also analyzed the lung IMP washout curve by a two-compartmental model. The mean E value for the nonsmoking controls was 0.977, indicating almost all IMP injected was taken up by the lungs at the initial passage. There was no difference in the E value among the groups. With regard to the lung IMP washout analysis, the distribution to the fast compartment (A{sub 1}) was smaller than that to the slow compartment (A{sub 2}). There was no difference in the A{sub 1} to A{sub 2} ratio among the groups. We then analyzed the slopes of the fast and slow compartments (k{sub 1}, k{sub 2}). There was no difference in k{sub 1} among the groups. On the other hand, k{sub 2} was larger in young healthy nonsmokers and smaller in healthy smokers, the patients with IPF, sarcoidosis and CPE than k{sub 2} in nonsmoking controls. Furthermore, k{sub 2} decreased in inverse proportion to age. We concluded that k{sub 2} could be a valuable index to detect changes of IMP, a lipophilic amine, metabolism in the lungs. (author).

Interpretation criteria for FDG PET/CT in multiple myeloma (IMPeTUs): final results. IMPeTUs (Italian myeloma criteria for PET USe).

Science.gov (United States)

Nanni, Cristina; Versari, Annibale; Chauvie, Stephane; Bertone, Elisa; Bianchi, Andrea; Rensi, Marco; Bellò, Marilena; Gallamini, Andrea; Patriarca, Francesca; Gay, Francesca; Gamberi, Barbara; Ghedini, Pietro; Cavo, Michele; Fanti, Stefano; Zamagni, Elena

2018-05-01

ᅟ: FDG PET/CT ( 18 F-fluoro-deoxy-glucose positron emission tomography/computed tomography) is a useful tool to image multiple myeloma (MM). However, simple and reproducible reporting criteria are still lacking and there is the need for harmonization. Recently, a group of Italian nuclear medicine experts defined new visual descriptive criteria (Italian Myeloma criteria for Pet Use: IMPeTUs) to standardize FDG PET/CT evaluation in MM patients. The aim of this study was to assess IMPeTUs reproducibility on a large prospective cohort of MM patients. Patients affected by symptomatic MM who had performed an FDG PET/CT at baseline (PET0), after induction (PET-AI), and the end of treatment (PET-EoT) were prospectively enrolled in a multicenter trial (EMN02)(NCT01910987; MMY3033). After anonymization, PET images were uploaded in the web platform WIDEN® and hence distributed to five expert nuclear medicine reviewers for a blinded independent central review according to the IMPeTUs criteria. Consensus among reviewers was measured by the percentage of agreement and the Krippendorff's alpha. Furthermore, on a patient-based analysis, the concordance among all the reviewers in terms of positivity or negativity of the FDG PET/CT scan was tested for different thresholds of positivity (Deauville score (DS 2, 3, 4, 5) for the main parameters (bone marrow, focal score, extra-medullary disease). Eighty-six patients (211 FDG PET/CT scans) were included in this analysis. Median patient age was 58 years (range, 35-66 years), 45% were male, 15% of them were in stage ISS (International Staging System) III, and 42% had high-risk cytogenetics. The percentage agreement was superior to 75% for all the time points, reaching 100% of agreement in assessing the presence skull lesions after therapy. Comparable results were obtained when the agreement analysis was performed using the Krippendorff's alpha coefficient, either in every single time point of scanning (PET0, PET-AI or PET-EoT) or

(123I)-IMP SPECT findings in Machado-Joseph disease

International Nuclear Information System (INIS)

Suzuki, Masahiko

1997-01-01

Single photon emission computed tomography (SPECT) with N-isopropyl-p-( 123 I)iodoamphetamine (IMP) was used to study the dynamics of cerebellar and brainstem metabolic function in patients with Mochado-Joseph disease (MJD), the diagnosis of which was confirmed with genetic analysis. The SPECT data obtained was analyzed semiquantitatively. In patients with MJD, ( 123 I)-IMP accumulation in the cerebellum and brainstem was decreased, and the degree of decrease reflected the clinical severity of MJD. When MJD was mild, the decrease in ( 123 I)-IMP accumulation was much greater in the brainstem than in the cerebellum. However, the decrease in ( 123 I)-IMP accumulation in the cerebellum and brainstem was not correlated with the severity of atrophy or with the number of CAG repeats. ( 123 I)-IMP SPECT was useful for evaluating the decrease in cerebellum and brainstem function in patients with MJD. Results of this study suggest that the functional decrease in MJD may begin in the brainstem. (author)

EDF group - Reference Document 2006

International Nuclear Information System (INIS)

2007-01-01

The EDF Group is an integrated energy supplier operating in a wide range of electricity-related businesses: generation, transmission, distribution, sale and trading of energy. It is the main operator in the French electricity market and holds strong positions in the other three principal European markets (Germany, the United Kingdom, Italy) making it one of the leading electricity groups in Europe, and a recognized actor in the gas market. With an installed capacity of 123.7 GW in Europe (128.2 GW worldwide) it holds, among the major European energy specialists, the largest production fleet and the one emitting the least CO 2 , owing to the share of nuclear technology and hydropower in its generation mix. The EDF group supplies electricity, gas and associated services to more than 37.8 million customers throughout the world and in Europe (more than 28 million of whom are in France). The EDF Group has built a business model balanced between France and the international markets, and between deregulated and regulated operations. In 2006, the Group recorded consolidated sales of euros 58,932 million, net income (Group share) of euros 5,605 million, and it achieved earnings before interest, taxes, depreciation and amortization of euros 13,930 million. From July 1, 2007, the EDF group will carry out its trading activities in a European energy market fully open to competition. This document is EDF Group's Reference Document for the year 2006. It contains information about: the Group activities, risk factors, Business overview, Organizational structure, Property, plants and equipment, Operating and financial review, Capital resources and cash flows, Research and Development, Patents and Licenses, Trend information, Financial forecasts or estimates, Administrative, management and supervisory bodies and senior management, Remuneration and benefits, Board practices, Employees/Human resources, Major shareholders, Related party transactions, Financial information

Prediction of progression in patients with mild cognitive impairment using IMP-SPECT

International Nuclear Information System (INIS)

Okamura, Nobuyuki; Shinkawa, Mitsutoshi; Arai, Hiroyuki; Matsui, Toshifumi; Nakajo, Kazushi; Maruyama, Masahiro; Hu, Xia Sheng; Sasaki, Hidetada

2000-01-01

To examine the difference in functional brain imaging between mild cognitive impairment (MCI) and normal aging, we measured rCBF on functional brain imaging using 123 I-IMP single photon emission computed tomography (IMP-SPECT) in 19 MCI patients who progressed to develop AD on follow-up and 23 probable Alzheimer's disease (AD) patients as well as 15 age-matched normal subjects. Baseline MMSE score was 25.3 (SD 1.2) in the MCI group and 17.5 (SD 3.3) in the AD group. The regions of interest (ROI) in the posterior cingulate gyrus, frontal, temporal and parietal cortices were drawn on the image of IMP-SPECT with reference to an individual MRI image. The rCBF ratio was calculated using ROI value in the cerebellum as a reference. Voxel-based analysis was also preformed using statistical parametric mapping (SPM). The rCBF ratio in the posterior cingulate gyrus was significantly reduced in the MCI group (mean 0.956, SD 0.080) and the AD group (mean 0.833, SD 0.118) compared to that in the normal group (mean 1.083, SD 0.084). In the frontal, temporal and parietal cortices, the rCBF ratio was significantly reduced only in the AD group compared to the normal group. At a fixed specificity of 80%, the diagnostic sensitivity in the discrimination between MCI patients and normal subjects was 80.5% when using rCBF ratio in posterior cingulate gyrus. In the SPM analysis, significant reduction of the rCBF in MCI group was observed only in the posterior cingulate gyrus, compared with normal subject group. Our results suggest that MCI patients presenting with a posterior cingulate hypoperfusion are at higher risk for transition from MCI to clinically recognizable AD. (author)

Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer

DEFF Research Database (Denmark)

Hammer, Niels A; Hansen, Thomas v O; Byskov, Anne Grete

2005-01-01

prompted us to examine their possible involvement in testicular neoplasia. IMPs were detected primarily in germ-cell neoplasms, including preinvasive testicular carcinoma in situ, classical and spermatocytic seminoma, and nonseminomas, with particularly high expression in undifferentiated embryonal...... carcinoma. The relative expression of IMP1, IMP2 and IMP3 varied among tumor types and only IMP1 was detected in all carcinoma in situ cells. Thus IMPs, and in particular IMP1, may be useful auxiliary markers of testicular neoplasia....

IMP - INTEGRATED MISSION PROGRAM

Science.gov (United States)

Dauro, V. A.

1994-01-01

IMP is a simulation language that is used to model missions around the Earth, Moon, Mars, or other planets. It has been used to model missions for the Saturn Program, Apollo Program, Space Transportation System, Space Exploration Initiative, and Space Station Freedom. IMP allows a user to control the mission being simulated through a large event/maneuver menu. Up to three spacecraft may be used: a main, a target and an observer. The simulation may begin at liftoff, suborbital, or orbital. IMP incorporates a Fehlberg seventh order, thirteen evaluation Runge-Kutta integrator with error and step-size control to numerically integrate the equations of motion. The user may choose oblate or spherical gravity for the central body (Earth, Mars, Moon or other) while a spherical model is used for the gravity of an additional perturbing body. Sun gravity and pressure and Moon gravity effects are user-selectable. Earth/Mars atmospheric effects can be included. The optimum thrust guidance parameters are calculated automatically. Events/maneuvers may involve many velocity changes, and these velocity changes may be impulsive or of finite duration. Aerobraking to orbit is also an option. Other simulation options include line-of-sight communication guidelines, a choice of propulsion systems, a soft landing on the Earth or Mars, and rendezvous with a target vehicle. The input/output is in metric units, with the exception of thrust and weight which are in English units. Input is read from the user's input file to minimize real-time keyboard input. Output includes vehicle state, orbital and guide parameters, event and total velocity changes, and propellant usage. The main output is to the user defined print file, but during execution, part of the input/output is also displayed on the screen. An included FORTRAN program, TEKPLOT, will display plots on the VDT as well as generating a graphic file suitable for output on most laser printers. The code is double precision. IMP is written in

Monitoring aeolian desertification process in Hulunbir grassland during 1975-2006, Northern China.

Science.gov (United States)

Guo, Jian; Wang, Tao; Xue, Xian; Ma, Shaoxiu; Peng, Fei

2010-07-01

The Hulunbir grassland experienced aeolian desertification expansion during 1975-2000, but local rehabilitation during 2000-2006. Northern China suffered severe aeolian desertification during the past 50 years. Hulunbir grassland, the best stockbreeding base in Northern China, was also affected by aeolian desertification. To evaluate the evolution and status of aeolian desertification, as well as its causes, satellite images (acquired in 1975, 1984, 2000, and 2006) and meteorological and socioeconomic data were interpreted and analyzed. The results show there was 2,345.7, 2,899.8, 4,053.9, and 3,859.6 km(2) of aeolian desertified land in 1975, 1984, 2000, and 2006, respectively. The spatial pattern dynamic had three stages: stability during 1975-1984, fast expansion during 1984-2000, and spatial transfer during 2000-2006. The dynamic degree of aeolian desertification is negatively related to its severity. Comprehensive analysis shows that the human factor is the primary cause of aeolian desertification in Hulunbir grassland. Although aeolian desertified land got partly rehabilitated, constant increase of extremely severe aeolian desertified land implied that current measures were not effective enough on aeolian desertification control. Alleviation of grassland pressure may be an effective method.

IMp: The customizable LEGO® Pinned Insect Manipulator

Directory of Open Access Journals (Sweden)

Steen Dupont

2015-02-01

Full Text Available We present a pinned insect manipulator (IMp constructed of LEGO® building bricks with two axes of movement and two axes of rotation. In addition we present three variants of the IMp to emphasise the modular design, which facilitates resizing to meet the full range of pinned insect specimens, is fully customizable, collapsible, affordable and does not require specialist tools or knowledge to assemble.

IMp: The customizable LEGO® Pinned Insect Manipulator

Science.gov (United States)

Dupont, Steen; Price, Benjamin; Blagoderov, Vladimir

2015-01-01

Abstract We present a pinned insect manipulator (IMp) constructed of LEGO® building bricks with two axes of movement and two axes of rotation. In addition we present three variants of the IMp to emphasise the modular design, which facilitates resizing to meet the full range of pinned insect specimens, is fully customizable, collapsible, affordable and does not require specialist tools or knowledge to assemble. PMID:25685035

Characterization of the Eimeria maxima sporozoite surface protein IMP1.

Science.gov (United States)

Jenkins, M C; Fetterer, R; Miska, K; Tuo, W; Kwok, O; Dubey, J P

2015-07-30

The purpose of this study was to characterize Eimeria maxima immune-mapped protein 1 (IMP1) that is hypothesized to play a role in eliciting protective immunity against E. maxima infection in chickens. RT-PCR analysis of RNA from unsporulated and sporulating E. maxima oocysts revealed highest transcription levels at 6-12h of sporulation with a considerable downregulation thereafter. Alignment of IMP1 coding sequence from Houghton, Weybridge, and APU-1 strains of E. maxima revealed single nucleotide polymorphisms that in some instances led to amino acid changes in the encoded protein sequence. The E. maxima (APU-1) IMP1 cDNA sequence was cloned and expressed in 2 different polyHis Escherichia coli expression vectors. Regardless of expression vector, recombinant E. maxima IMP1 (rEmaxIMP1) was fairly unstable in non-denaturing buffer, which is consistent with stability analysis of the primary amino acid sequence. Antisera specific for rEmaxIMP1 identified a single 72 kDa protein or a 61 kDa protein by non-reducing or reducing SDS-PAGE/immunoblotting. Immunofluorescence staining with anti-rEmaxIMP1, revealed intense surface staining of E. maxima sporozoites, with negligible staining of merozoite stages. Immuno-histochemical staining of E. maxima-infected chicken intestinal tissue revealed staining of E. maxima developmental stages in the lamnia propia and crypts at both 24 and 48 h post-infection, and negligible staining thereafter. The expression of IMP1 during early stages of in vivo development and its location on the sporozoite surface may explain in part the immunoprotective effect of this protein against E. maxima infection. Published by Elsevier B.V.

IMP3 expression is associated with poor outcome and epigenetic deregulation in intrahepatic cholangiocarcinoma.

Science.gov (United States)

Gao, Yuanyuan; Yang, Michelle; Jiang, Zhong; Woda, Bruce A; Mercurio, Arthur M; Qin, Jianjie; Huang, Xinli; Zhang, Feng

2014-06-01

IMP3 is a fetal protein not expressed in normal adult tissues. IMP3 is an oncoprotein and a useful biomarker for a variety of malignancies and is associated with reduced overall survival of a number of them. IMP3 expression and its prognostic value for patients with intrahepatic cholangiocarcinoma (ICC) have not been well investigated. The molecular mechanism underlying IMP3 expression in human cancer cells remains to be elucidated. Here we investigated IMP3 expression in ICC and adjacent nonneoplastic liver in 72 unifocal primary ICCs from a single institute by immunohistochemistry, immunoblotting, and real-time polymerase chain reaction. IMP3 was specifically expressed in cancer cells but not in the surrounding normal tissue, and 59 (82%) of 72 ICCs were IMP3 positive by immunohistochemistry. Among 35 cases with lymphovascular invasion, 26 (74%) showed IMP3 positivity in lymph node metastases. IMP3 expression was significantly correlated with tumor size, pathological grade, metastasis, and clinical stage. Kaplan-Meier analysis demonstrated an inverse correlation between IMP3 expression and overall survival rate. Multivariate analysis revealed that IMP3 was the only risk factor associated with survival. To further explore the mechanism of IMP3 expression in cancers, we identified 2 CpG islands at IMP3 proximal promoter. Interestingly, the IMP3 promoter was almost completely demethylated in ICCs in contrast to densely methylated promoter in normal liver tissues. IMP3 expression is a useful biomarker for ICCs and can provide an independent prognostic value for patients with ICC. To our knoweldge, this is the first direct evidence of epigenetic deregulation of IMP3 in human cancer. Copyright © 2014 The Auhtors. Published by Elsevier Inc. All rights reserved.

Role of 123I-IMP SPET in the early diagnosis of borderline chronic hydrocephalus after aneurysmal subarachnoid haemorrhage

International Nuclear Information System (INIS)

Ohkuma, Hiroki; Tanaka, Masahiko; Suzuki, Shigeharu; Kondoh, Izumi

2000-01-01

Chronic hydrocephalus after aneurysmal subarachnoid haemorrhage (SAH) is easily diagnosed in most cases. However, the diagnosis is sometimes difficult in borderline cases, in which (a) pathognomonic clinical deterioration due to hydrocephalus is masked by the neurological deficits caused in the acute stage of SAH and (b) ventricular enlargement is not so marked on CT scan. The purpose of this study was to investigate whether or not iodine-123 labelled N-isopropyl-p-iodoamphetamine ( 123 I-IMP) single-photon emission tomography (SPET) is of value for the early diagnosis of borderline chronic hydrocephalus after SAH. Fifteen patients who met the criteria of borderline chronic hydrocephalus were selected for the study, and underwent a shunt operation. The patients were divided into a shunt-effective group and a shunt-ineffective group according to neurological improvement after the shunt operation. 123 I-IMP SPET was performed in the acute stage of SAH, within 1 week before the shunt operation, and 2 weeks after the shunt operation. Regional cerebral blood flow was estimated by the 123 I-IMP autoradiographic method. Pre-shunting periventricular low-perfusion areas showed statistically significant differences between the two groups (P 123 I-IMP SPET can be used for both the early diagnosis of borderline chronic hydrocephalus after SAH and the prediction of shunt effectiveness. (orig.)

Integrated maintenance program (IMP)

International Nuclear Information System (INIS)

Zemdegs, R.T.; Chout, Q.B.

1998-01-01

Approaches to the maintenance of nuclear power plants have undergone significant change in the past several decades. The traditional breakdown approach has been displaced by preventive (calendar-based) maintenance and more recently, by condition-based maintenance (CBM). This is largely driven by the fact that traditional maintenance programs, derived primarily from equipment vendor recommendations, are generally unsuccessful in controlling maintenance costs or equipment failures. Many advances in the maintenance field have taken place since the maintenance plans for Ontario Hydro's nuclear plants were initially established. Ontario Hydro nuclear plant operating costs can be substantially reduced and Incapability Factor improved with the application of modern maintenance processes and tools. Pickering is designated as the lead station for IMP. Of immediate concern is the fact that Pickering Nuclear Division has been experiencing a significant backlog of Operating Preventive Maintenance Callups. This backlog, over 2000, is unacceptable to both station management and the nuclear regulator, the Atomic Energy Control Board. In addition there are over 500 callups in various stages of revision (in hyperspace) without an adequate control nor reporting system to manage their completion. There is also considerable confusion about the classification of l icensing c allups, e.g. callups which are mandatory as a result of legal requirements. Furthermore the ineffectiveness of the Preventive Maintenance (PM) has been the subject of peer audits and Atomic Energy Control Board (AECB) findings over the past several years. The current preventive maintenance ratio PM2 /(PM+CM3) at Pickering ND is less than 20%, due to the current high load of equipment breakdown. This past summer, an Independent Integrated Performance Assessment (IIPA) review at Ontario Hydro confirmed these concerns. Over the past several years, Ontario Hydro nuclear staff have evaluated several programs to improve

IMP3 expression in human ovarian cancer is associated with improved survival

DEFF Research Database (Denmark)

Noske, Aurelia; Faggad, Areeg; Wirtz, Ralph

2009-01-01

The insulin-like growth factor-II mRNA-binding protein IMP3 plays an important role in embryogenesis and recent reports suggest an involvement in tumorigenesis. Although IMP3 expression has been well studied in mouse and human fetal and adult gonads, its role in ovarian cancer is unknown. We...... investigated the expression of IMP3 at protein and mRNA levels in a cohort of primary ovarian carcinomas and in 11 ovarian cancer cell lines. Western blot analysis revealed an expression of IMP3 in all ovarian cancer cell lines and immunohistochemistry demonstrated a positive cytoplasmic staining in 32 of 68...... carcinomas (47%). In contrast, epithelium of borderline tumors, as well as, benign ovarian lesions and normal ovaries exhibited only weak or no IMP3 expression. In univariate Kaplan-Meier analysis, IMP3 protein expression was significantly associated with better overall survival (P=0.048). To confirm...

Detection of bla-IMP-1 and bla-IMP-2 Genes Among Metallo-β-lactamase-Producing Pseudomonas Aeruginosa Isolated from Burn Patients in Isfahan

Directory of Open Access Journals (Sweden)

M. Pourbabaee

2016-02-01

Full Text Available Background: Pseudomonas aeruginosa is a nosocomial pathogen which especially causes infections among burn patients. Carbapenems are extensively used for the treatment of infections caused by multidrug-resistant P. aeruginosa isolates. The emergence of carbapenemases producing isolates is an outcome of increased utilization of carbapenems. The aim of this study was to determine the bla-IMP-1 and bla-IMP-2 genes in metallo-β-lactamase (MBL -producing Pseudomonas aeruginosa isolated from burn patients in Isfahan. Material and Methods: A total of 150 P. aeruginosa were isolated from burn patients hospitalized in Imam-Mousakazem hospital in Isfahan. Antimicrobial susceptibility was determined using disk diffusion method according to the Clinical and Laboratory Standards Institute (CLSI guidelines. Double Disk Synergy Test (DDST was carried out for screening of MBL production in imipenem-resistant strains. PCR assays were used for detection of bla-IMP-1 and bla-IMP-2 genes among metallo-β-lactamase-producing Pseudomonas aeruginosa isolates. The purified PCR products were sequenced. Results: Of 150 Pseudomonas aeruginosa isolates, %100 identified as multi-drug resistant strains. The most resistance rates were seen against ciprofloxacin, tobromycin, meropenem and imipenem. All of 144 imipenem-resistant Pseudomonas aeruginosa isolates were MBL producing by DDST test. Twenty-nine (19.3% and 8(5.3% MBL producing Pseudomonas aeruginosa isolates harbored bla-IMP-1 and bla-IMP-2 genes respectively. Conclusions: According to results of this study high level resistance to imipenem and MBl genes carriage was seen among Pseudomonas aeruginosa isolated from burn patient infections in our region.

Medida Interpessoal de Psicopatia (IM-P: estudo preliminar no contexto brasileiro Interpersonal Measure of Psychopathy (IM-P: preliminary study in the Brazilian context

Directory of Open Access Journals (Sweden)

Tárcia Rita Davoglio

2011-01-01

Full Text Available INTRODUÇÃO: A observação direta do comportamento interpessoal é um recurso importante na descrição e diagnóstico da personalidade psicopática. A Medida Interpessoal de Psicopatia (Interpersonal Measure of Psychopathy, IM-P é um instrumento psicométrico composto por 21 itens, desenvolvido para ser utilizado em associação com outras escalas de avaliação da psicopatia. Foca-se, especificamente, nos comportamentos interpessoais e aspectos não verbais evidentes na interação do entrevistador com indivíduos que apresentam características psicopáticas. OBJETIVO: Descrever resultados preliminares sobre a investigação de aspectos interpessoais da psicopatia mediante a utilização da IM-P, incluindo as etapas de tradução/adaptação e avaliação de confiabilidade interavaliadores da IM-P, em uma amostra de adolescentes brasileiros. MÉTODO: Trata-se de estudo transversal, descritivo e correlacional realizado com 20 adolescentes masculinos cumprindo medida socioeducativa com privação de liberdade na Região Metropolitana de Porto Alegre (RS. Após os procedimentos de tradução da escala, treinamento dos pesquisadores e teste piloto por meio de uma entrevista semiestruturada, a IM-P foi pontuada por três juízes independentes. RESULTADOS: Os resultados estatísticos, obtidos através do coeficiente de concordância de Kendall, revelaram grau de concordância interavaliadores elevado e satisfatório para os escores totais da IM-P (W = 0,84; p INTRODUCTION: The direct observation of interpersonal behaviors is an important resource in the description and diagnosis of the psychopathic personality. The Interpersonal Measure of Psychopathy (IM-P is a psychometric instrument comprised of 21 items, designed to be applied in association with other instruments that also evaluate psychopaths. It focuses specifically on interpersonal and non-verbal behaviors that become evident during the interaction between the interviewer and individuals

IMp: The customizable LEGO(®) Pinned Insect Manipulator.

Science.gov (United States)

Dupont, Steen; Price, Benjamin; Blagoderov, Vladimir

2015-01-01

We present a pinned insect manipulator (IMp) constructed of LEGO® building bricks with two axes of movement and two axes of rotation. In addition we present three variants of the IMp to emphasise the modular design, which facilitates resizing to meet the full range of pinned insect specimens, is fully customizable, collapsible, affordable and does not require specialist tools or knowledge to assemble.

Effects of cigarette smoking on I-123 IMP clearance from the lung

International Nuclear Information System (INIS)

Katoh, Kunihiko; Takahashi, Tsuneo

1990-01-01

N-isopropyl-p-I-123-iodoamphetamine (I-123 IMP), originally developed as a brain scanning agent, is also taken up by the lung. To evaluate the cigarette smoking on the uptake of IMP by the lung, we studied I-123 IMP clearance from the lung on 14 volunteers; 5 non-smokers and 9 smokers. After the injection of 111 MBq (3mCi) of I-123 IMP into the medial cubital vein, the time-activity curve for 60 minutes and the regional activity using 1 frame per minute and a 64 x 64 matrix was obtained. I-123 IMP clearance curve was described as follows: C(t)=A 1 e -k1t +A 2 e -k2t (A 1 , A 2 : intercepts, and k 1 , k 2 : slopes of the exponential components). I-123 IMP clearance was delayed in smokers, and k 2 was smaller in smokers. Also a significant correlations between k 1 , k 2 , and the number of cigarettes smoked per day were found. In conclusion, this study suggests that the delayed clearance and retention of I-123 IMP in the lung indicate the lung metabolic disorders due to cigarette smoking. (author)

Incorporation of a recombinant Eimeria maxima IMP1 antigen into nanoparticles confers protective immunity against E. Maxima challenge infection.

Science.gov (United States)

Jenkins, Mark C; Stevens, Laura; O'Brien, Celia; Parker, Carolyn; Miska, Katrzyna; Konjufca, Vjollca

2018-02-14

The purpose of this study was to determine if conjugating a recombinant Eimeria maxima protein, namely EmaxIMP1, into 20 nm polystyrene nanoparticles (NP) could improve the level of protective immunity against E. maxima challenge infection. Recombinant EmaxIMP1 was expressed in Escherichia coli as a poly-His fusion protein, purified by NiNTA chromatography, and conjugated to 20 nm polystyrene NP (NP-EmaxIMP1). NP-EMaxIMP1 or control non-recombinant (NP-NR) protein were delivered per os to newly-hatched broiler chicks with subsequent booster immunizations at 3 and 21 days of age. In battery cage studies (n = 4), chickens immunized with NP-EMaxIMP1 displayed complete protection as measured by weight gain (WG) against E. maxima challenge compared to chickens immunized with NP-NR. WG in the NP-EMaxIMP1-immunized groups was identical to WG in chickens that were not infected with E. maxima infected chickens. In floor pen studies (n = 2), chickens immunized with NP-EMaxIMP1 displayed partial protection as measured by WG against E. maxima challenge compared to chickens immunized with NP-NR. In order to understand the basis for immune stimulation, newly-hatched chicks were inoculated per os with NP-EMaxIMP1 or NP-NR protein, and the small intestine, bursa, and spleen, were examined for NP localization at 1 h and 6 h post-inoculation. Within 1 h, both NP-EMaxIMP1 and NP-NR were observed in all 3 tissues. An increase was observed in the level of NP-EmaxIMP1 and NP-NR in all tissues at 6 h post-inoculation. These data indicate that 20 nm NP-EmaxIMP1 or NP-NR reached deeper tissues within hours of oral inoculation and elicited complete to partial immunity against E. maxima challenge infection. Published by Elsevier Ltd.

EDF Group - Annual Report 2006

International Nuclear Information System (INIS)

2007-01-01

The EDF Group is a leading player in the European energy industry, present in all areas of the electricity value chain, from generation to trading, and increasingly active in the gas chain in Europe. Leader in the French electricity market, the Group also has solid positions in the United Kingdom, Germany and Italy. In the electricity sector, it has the premier generation fleet and customer portfolio in Europe and operates in strategically targeted areas in the rest of the world. The Group is also the leading network operator in Europe, giving it a sound business model, equally balanced between regulated activities and those open to competition. This document is EDF Group's annual report for the year 2006. It contains information about Group profile, governance, business, development strategy, sales and marketing, positions in Europe and international activities. The document is made of several reports: the Activity and Sustainable Development Report, the Financial Report, the Sustainable Development Report, the Sustainable Development Indicators, and the Report by the Chairman of EDF Board of Directors on corporate governance and internal control procedures

Molecular composition of IMP1 ribonucleoprotein granules

DEFF Research Database (Denmark)

Jønson, Lars; Vikesaa, Jonas; Krogh, Anders

2007-01-01

Localized mRNAs are transported to sites of local protein synthesis in large ribonucleoprotein (RNP) granules, but their molecular composition is incompletely understood. Insulin-like growth factor II mRNA-binding protein (IMP) zip code-binding proteins participate in mRNA localization, and in mo......Localized mRNAs are transported to sites of local protein synthesis in large ribonucleoprotein (RNP) granules, but their molecular composition is incompletely understood. Insulin-like growth factor II mRNA-binding protein (IMP) zip code-binding proteins participate in mRNA localization...

Wind and IMP 8 Solar Wind, Magnetosheath and Shock Data

Science.gov (United States)

2004-01-01

The purpose of this project was to provide the community access to magnetosheath data near Earth. We provided 27 years of IMP 8 magnetosheath proton velocities, densities, and temperatures with our best (usually 1-min.) time resolution. IMP 8 crosses the magnetosheath twice each 125 day orbit, and we provided magnetosheath data for the roughly 27 years of data for which magnetometer data are also available (which are needed to reliably pick boundaries). We provided this 27 years of IMP 8 magnetosheath data to the NSSDC; this data is now integrated with the IMP 8 solar wind data with flags indicating whether each data point is in the solar wind, magnetosheath, or at the boundary between the two regions. The plasma speed, density, and temperature are provided for each magnetosheath point. These data are also available on the MIT web site ftp://space .mit.edu/pub/plasma/imp/www/imp.html. We provide ASCII time-ordered rows of data giving the observation time, the spacecraft position in GSE, the velocity is GSE, the density and temperature for protons. We also have analyzed and archived on our web site the Wind magnetosheath plasma parameters. These consist of ascii files of the proton and alpha densities, speeds, and thermal speeds. These data are available at ftp://space.mit.edu/pub/plasma/wind/sheath These are the two products promised in the work statement and they have been completed in full.

Brazilian research groups in nursing: comparison of 2006 and 2016 profiles.

Science.gov (United States)

Erdmann, Alacoque Lorenzini; Peiter, Caroline Cechinel; Lanzoni, Gabriela Marcellino de Melo

2017-07-13

To compare the profile of nursing research groups registered at the CNPq Research Groups Directory in 2006 and 2016. Descriptive and documentary analysis, The data has been collected in 2006 and in 2016, with parameterized search with the term "nursing" at the CNPq Research Groups Directory. The selected variables have been organized in a Microsoft Office Exce spreadsheetl. The research groups have increased from 251 in 2006 to 617 in 2016, with important increase of the number of participants, among students and researchers. There was a decrease of the number of groups without students. However, 22% remain without undergraduate students' participation. It has been observed an important increase regarding the interest on research activities, when comparing both scenarios. The nursing research groups reflect structural and political advances in generation of science, technology and innovation, however, the undergraduate students' and the foreign researchers' participation should still be encouraged.

Study of 123I-IMP SPECT on diabetic patients

International Nuclear Information System (INIS)

Kinoshita, Ikuo; Takeo, Goh; Iwanaga, Keisuke; Uotani, Shigeo; Nakamura, Minoru; Sohda, Masanori; Ohe, Haruto; Toshimitsu, Takashi; Ohe, Nobuharu

1991-01-01

The involvement of peripheral nerves and nerve roots often leads to neurological manifestations which have frequently been described in association with diabetes mellitus. Whether there is any specific involvement of the central nervous system in this process has yet to be determined. Recently, many reports have suggested that significant neurophysiologic abnormalities in the central nervous system can sometimes be found in diabetic patients. In order to accurately examine the existence of central nervous system involvement in patients with diabetes mellitus, comparisons of 123 I-IMP (IMP) washout rates were made between normal adults (n=19, average age 43.3 years) and diabetic patients (n=23, average age 43.3 years), and these results were graphically demonstrated by color images. Early images were obtained 30 minutes after intravenous injection, while delayed images were made 4 hours after injection. The IMP washout rate was obtained by subtracting the values of the delayed image with the early image. The standard deviation (SD) of the IMP washout rate for each patient was compared to the averaged SD obtained from healthy adults. After calculating the deviation from SD levels of healthy adults, we made an image of the patient's IMP washout rates. These images were divided into seven degrees (I, II: normal, III, IV: borderline, V∼VII: abnormal) and the ratio of each degree was expressed by a histogram in each cerebral hemisphere as the washout rate index. In 23 diabetic subjects, seven patients were found to be borderline while sixteen patients were abnormal. These impairments were not related either to the presence of diabetic triopathy or the duration of disease. By utilising such a noninvasive method, we were able to accurately evaluate the extent of diabetic central neuropathy. Therefore this subtraction method, which uses the specificity of IMP SPECT, is thus considered to be highly useful for broad clinical application. (author)

IMP and NLHIAL annual report (1999)

International Nuclear Information System (INIS)

2000-07-01

In the year of 1999, HIRFL-CSR, a new project proposed by IMP and NLHIAL was approved by the Chinese government, and started to build up. The research result, and activities of IMP and NLHIAL during the year of 1999 was summarized. The contents were divided into two parts. Part A presented by National Laboratory of Heavy Ion Accelerator in Lanzhou (NLHIAL). It includes experimental nuclear physics and nuclear chemistry, application of heavy ion physics, accelerator and the others. Part B presented by Institute of Modern Physics. It includes theoretical nuclear physics, experimental nuclear physics and nuclear chemistry. Application of heavy ion physics and nuclear technique, computer technique and electronics, accelerator and the others

Gelman: El salario del impío

Directory of Open Access Journals (Sweden)

Jorge José Monteleone

2000-11-01

Full Text Available En su "Discurso sobre lírica y sociedad", Theodor W Adorno señala que el poema lírico debe presentar un alto "grado de interiorización y una radical individuación". Es decir, que el contenido del poema será tanto más objetivo y motivado socialmente cuanto menos se "tematice" en el la relación entre el yo y la sociedad y que el sujeto estará menos ausente de la forma poética que lo presenta, cuanto mas se sumerja y olvide en la objetividad social del lenguaje. A k luz de esas nociones pueden leerse dos libros de Juan Gelman, que se refieren explícitamente al exilio: Bajo la lluvia ajena (notas al pie de una derrota (1984 y Salarios del impío (1993. Entre uno y otro se percibe una progresiva individuación que permite alcanzar formalmente en el lenguaje poético una eficaz representación imaginaria del hecho histórico opresivo, que elude la reducción temática. Asimismo, la noción de posterioridad, con k cual se reinscribe y reorganiza la significación de un hecho traumático del pasado en un trabajo de la memoria, permitiría revisar aquella célebre advertencia de Adorno según la cual seria imposible escribir poesía después de un genocidio.

Gelman: El salario del impío

Directory of Open Access Journals (Sweden)

Jorge José Monteleone

2001-11-01

Full Text Available En su "Discurso sobre lírica y sociedad", Theodor W Adorno señala que el poema lírico debe presentar un alto "grado de interiorización y una radical individuación". Es decir, que el contenido del poema será tanto más objetivo y motivado socialmente cuanto menos se "tematice" en el la relación entre el yo y la sociedad y que el sujeto estará menos ausente de la forma poética que lo presenta, cuanto mas se sumerja y olvide en la objetividad social del lenguaje. A k luz de esas nociones pueden leerse dos libros de Juan Gelman, que se refieren explícitamente al exilio: Bajo la lluvia ajena (notas al pie de una derrota (1984 y Salarios del impío (1993. Entre uno y otro se percibe una progresiva individuación que permite alcanzar formalmente en el lenguaje poético una eficaz representación imaginaria del hecho histórico opresivo, que elude la reducción temática. Asimismo, la noción de posterioridad, con k cual se reinscribe y reorganiza la significación de un hecho traumático del pasado en un trabajo de la memoria, permitiría revisar aquella célebre advertencia de Adorno según la cual seria imposible escribir poesía después de un genocidio.

Status and prospect of super-heavy nuclei research at IMP

International Nuclear Information System (INIS)

Xu Hushan; Sun Zhiyu; Zhan Wenlong; Zhou Xiaohong; Huang Wenxue; Zhang Hongbin; Gan Zaiguo; Li Junqing; Ma Xinwen; Qin Zhi; Xiao Guoqing; Guo Zhongyan; Li Zhihui; Zhang Yuhu; Jin Genming; Huang Tianheng; Hu Zhengguo; Zhang Xueheng; Zheng Chuan; Chinese Academy of Sciences, Beijing

2006-01-01

The history and the international status of the super-heavy nuclei synthesis are briefly described. The related research work carried out at the Institute of Modern Physics (IMP) has been reviewed. The prospect of the super-heavy nuclei research at IMP has been introduced. (authors)

[Mycoses in Venezuela: Working Groups in Mycology reported cases (1984-2010)].

Science.gov (United States)

Martínez Méndez, Dilia; Hernández Valles, Rosaura; Alvarado, Primavera; Mendoza, Mireya

2013-01-03

In 1984 the Venezuelan Work Groups in Mycology (VWGM) were created introducing an innovative approach to the study of the mycoses in Venezuela. To study the occurrence of the mycoses in Venezuela. Review the reported cases of mycoses by the newsletter Boletín Informativo Las Micosis en Venezuela (VWGM) from 1984 to 2010. The data collected showed 36,968 reported cases of superficial mycoses, 1,989 of deep systemic cases, and 822 of localized mycoses. Pityriasis dermatophytosis was the most common superficial infection, and paracoccidioidomycosis and histoplasmosis the most frequent deep systemic infection. Chromoblastomycosis was the most frequently diagnosed subcutaneous infection. The data provided showed the distribution by geographical area for each of the fungal infections studied, which may help to establish the endemic areas. Superficial mycosis is a public health problem due to its high morbidity and is probably responsible for some of the outbreaks in high-risk groups. Paracoccidioidomycosis and histoplasmosis were reported more often, which agrees with earlier reports prior to the formation of the VWGM. Cases of sporotrichosis and chromoblastomycosis in Venezuela can be considered unique due to the high number of cases. This study highlights the contribution of the VWGM to the behavior of the mycoses in Venezuela, its incidence, prevalence, and the recognition of these infections as a problem of public health importance. The VWGM should keep working in this endeavor, not only reporting new cases, but also unifying the clinical and epidemiological criteria, in order to properly monitor the evolving epidemiological changes reported in these types of infections. Copyright © 2012 Revista Iberoamericana de Micología. Published by Elsevier España, S.L. All rights reserved.

Regional cerebral blood flow in various pediatric neurological patients using 123I-IMP SPECT

International Nuclear Information System (INIS)

Konishi, Tohru; Naganuma, Yoshihiro; Hongou, Kazuhisa; Murakami, Miyako; Yamatani, Miwa; Okada, Toshio

1988-01-01

The recent development of a new radiopharmaceutical 123 I-isopropyl-iodoamphetamine (IMP), which is taken up by the brain from the blood flow, has offered a possibility of constructing scintigraphy maps of regional cerebral blood flow (rCBF) using single photon emission CT. We used this mehtod in various pediatric neurological diseases. Six patients with cerebro-vascular disorders (moya-moya disease 2, infarction 3 and HHE syndrome 1), 6 patients with infectious diseases of CNS (acute encephalitis 4, septic meningitis 1 and SSPE 1) and a miscellaneous group of six patients were studied. The rCBF abnormalities in cerebro-vascular diseases were more extensive and frequent than x-ray CT abnormalities. Repeated studies of IMP-SPECT revealed usefulness for the understanding of changeable hemodynamic pathophysiology and for the judgment of theraptic effectiveness and prognosis. The rCBF decrease in infectious diseases tended to be more diffuse and slight than that in cerebro-vascular diseases. In almost all patients, the area of rCBF decrease coincided with the area of EEG slowing evaluated by EEG topographic analysis. Brain imaging using 123 I-IMP SPECT may reveal functional abnormalities as well as organic lesions. 123 I-IMP SPECT has introduced a new era for the useful application of nuclear medicine to the investigation of pediatric neurological diseases. (author)

Clinical evaluation of 123I-IMP SPECT in patients with various neurological diseases

International Nuclear Information System (INIS)

Yoneda, Naoto

1993-01-01

Single photon emission computed tomography with N-isopropyl-p-[ 123 I] iodoamphetamine ( 123 I-IMP SPECT) was performed in 57 patients with various neurological disease, and compared with the findings of brain CT, MRI, and EEG. The author also evaluated the relationship between the findings on 123 I-IMP SPECT and the condition of the control of the attack after treatment with antiepileptic drugs in idiopathic epileptic patients. Abnormality of accumulation of 123 I-IMP SPECT was observed in 62.3% of all cases. Focal abnormality was detected in 28.3% of all cases by brain CT and 54.1% by MRI. The detectability of focal abnormality in brain CT and MRI was found to be lower than that of 123 I-TMP SPECT. There was very little significance in detectability between 123 I-IMP SPECT and EEG. But it infers that 123 I-IMP SPECT can detect the subictal state in epileptic patients. One comparative study of the relationship between the findings on 123 I-IMP SPECT and the condition of the control of the attack by antiepileptic drugs in patients with idiopathic epilepsy, abnormality of 123 I-IMP SPECT findings was found to be higher in patients who were not controlled sufficiently than in patients who were controlled sufficiently, and a significant difference is found by X 2 test. 123 I-IMP SPECT is useful for the evaluation of treatment in patients with epilepsy. (author)

The network researchers' network

DEFF Research Database (Denmark)

Henneberg, Stephan C.; Jiang, Zhizhong; Naudé, Peter

2009-01-01

The Industrial Marketing and Purchasing (IMP) Group is a network of academic researchers working in the area of business-to-business marketing. The group meets every year to discuss and exchange ideas, with a conference having been held every year since 1984 (there was no meeting in 1987). In thi......The Industrial Marketing and Purchasing (IMP) Group is a network of academic researchers working in the area of business-to-business marketing. The group meets every year to discuss and exchange ideas, with a conference having been held every year since 1984 (there was no meeting in 1987......). In this paper, based upon the papers presented at the 22 conferences held to date, we undertake a Social Network Analysis in order to examine the degree of co-publishing that has taken place between this group of researchers. We identify the different components in this database, and examine the large main...

123I-IMP SPECT studies in schizophrenia and atypical psychosis

International Nuclear Information System (INIS)

Hayashi, Takuji; Suga, Hidemichi

1993-01-01

According to the classification of Mitsuda, 23 patients with endogenous psychosis aged 40 years or younger, presenting with hallucination and delusion, were classified as having schizophrenia (n=12) or atypical psychosis (n=11). These patients were studied by single photon emission computed tomography (SPECT) with N-isopropyl-p-I-123-iodoamphetamine (I-123 IMP). Sixteen healthy persons served as controls. Early and delayed SPECT images were obtained 30 min and 4 hr, respectively, after intravenous injection of I-123 IMP. The group of schizophrenic patients had markedly decreased uptake of I-123 in the basal ganglia, as well as the right temporal and left occipital areas on both early and delayed images. In the group of atypical psychosis patients, however, decreased uptake of I-123 was noted in both the right basal ganglia and left occipital area on early images, but none of such findings were seen on delayed images. Regarding the uptake ratio in the frontal area on both early and delayed images, there were significant differences between the two groups. These findings have important implications for the different etiology of both disease types: not only functional disturbance in the frontal area but also irreversible changes may be involved in the occurrence of schizophrenia, and functional disturbance particularly in the right basal ganglia may be involved in the occurrence of atypical psychosis. (N.K.)

Hypoxic Vasospasm Mediated by cIMP: When Soluble Guanylyl Cyclase Turns Bad.

Science.gov (United States)

Gao, Yuansheng; Chen, Zhengju; Leung, Susan W S; Vanhoutte, Paul M

2015-06-01

In a number of isolated blood vessel types, hypoxia causes an acute contraction that is dependent on the presence of nitric oxide and activation of soluble guanylyl cyclase. It is more pronounced when the preparations are constricted and is therefore termed hypoxic augmentation of vasoconstriction. This hypoxic response is accompanied by increases in the intracellular level of inosine 5'-triphosphate and in the synthesis of inosine 3',5'-cyclic monophosphate (cIMP) by soluble guanylyl cyclase. The administration of exogenous cIMP or inosine 5'-triphosphate causes augmented vasoconstriction to hypoxia. Furthermore, the vasoconstriction evoked by hypoxia and cIMP is associated with increased activity of Rho kinase (ROCK), indicating that cIMP may mediate the hypoxic effect by sensitizing the myofilaments to Ca through ROCK. Hypoxia is implicated in exaggerated vasoconstriction in the pathogenesis of coronary artery disease, myocardial infarction, hypertension, and stroke. The newly found role of cIMP may help to identify unique therapeutic targets for certain cardiovascular disorders.

Recent nuclear physics research at IMP

International Nuclear Information System (INIS)

Jin Genming

1998-01-01

The recent progresses in the nuclear physics research in IMP (Institute of Modern Physics) are reviewed including the synthesis and studies of nuclei far from stability and properties of hot nuclei. Heavy Ion Research Facility Lanzhou (HIRFL) is of cyclotron family delivering intermediate energy heavy ions. During the recent years, progresses have been made in the studies of heavy ion physics as well as in the development of the HIRFL. This paper will begin with the recent upgrading of HIRFL with an emphasis on the development of Radioactive Ion Beam Line Lanzhou (RIBLL), and then be focused on the physics research in IMP including intermediate energy heavy ion collisions and hot nuclei, synthesis and studies of nuclei far from stability. (J.P.N)

Clinical significance of I-123 IMP brain SPECT in children with brain diseases

International Nuclear Information System (INIS)

Takishima, Teruo; Machida, Kikuo; Honda, Norinari; Mamiya, Toshio; Takahashi, Taku; Kamano, Tsuyoshi; Hasegawa, Noriko

1990-01-01

Single photon emission computed tomography (SPECT) of the brain using N-isopropyl p-I-123-iodoamphetamine (I-123 IMP) was performed in 43 children with suspected brain diseases. Forty-three children (25 males and 18 females), with an age range of 24 days-15 years (mean: 6.6 years), were included in the study. Six patients were subsequently diagnosed as normal. Early SPECT of the brain was performed 30 minutes after intravenous administration of 74-111 MBq (2-3 mCi) I-123 IMP using a rotating gamma camera equipped with a 30-degree slant hole and medium energy collimator. Transverse images were reconstructed by Shepp-Logan filtered back projection method with attenuation correction after spatial filtering using an 8th order Butterworth-Wiener filter. Findings of I-123 IMP SPECT were compared with those of X-ray computed tomography (CT) and electroencephalography (EEG). The results showed that in I-123 IMP SPECT, abnormality was found in 30 out of 37 children with brain diseases. The incidence of abnormal findings in the 37 patients was 81% in I-123 IMP SPECT, 61% in X-ray CT, and 78% in EEG; in both cryptogenic and secondary epilepsy, the incidence of abnormality was higher in I-123 IMP SPECT than in X-ray CT. (70% and 94% vs 50% and 81% respectively), and epileptic foci detected by EEG did not correspond with defects found using I-123 IMP SPECT in 27% of the patients; and in asphyxiated infants, a high incidence of abnormality was observed on both I-123 IMP SPECT (86%) and X-ray CT (86%). In conclusion, I-123 IMP SPECT is a clinically useful examination in children with brain disease. (author)

Analysis of I-125 IMP and its metabolites using a high performance liquid chromatography

International Nuclear Information System (INIS)

Satoh, Motohiro; Ishikawa, Nobuyoshi; Takeda, Tohoru; Jin, Wu; Kuramoto, Kenmei; Itai, Yuji; Yoshizawa, Takashi; Nakajima, Kotaro.

1991-01-01

The biodistribution of N-isopropyl-p-[I-123]iodoamphetamine (IMP) and its metabolites was examined in rabbits and Mongolian gerbils. Arterial sampling was performed at one, 5, 15, and 30 min, and one, 3, and 6 hr after bolus iv injection of IMP for the hemodynamic investigation. Similarly, the cerebral hemisphere, lung, liver, and blood samples were collected at 15 min and 3 hr for analyzing IMP metabolites. Activity count in blood was gradually increased from 15 min to 3 hr after iv injection, and thereafter decreased. Relative fraction of IMP in plasma was gradually increased to a plateau value of 80% at one hr. Octanol extraction ratio was decreased to 24.3% at 3 hr, although it was 100% immediately after iv injection. Early (15 min) and delayed (3 hr) analysis using high performance liquid chromatography (HPLC) revealed p-iodoamphetamine (PIA) and p-iodobenzoic acid (PIB) as major metabolites of IMP. Although IMP accounted for the majority on both early and delayed HPLC, the quantity of PIA in the normal hemisphere and lung was significantly increased on delayed HPLC, compared to early HPLC. For the liver, the quantities of both PIA and PIB were larger than IMP on both early and delayed HPLC. The proportion of metabolites also became greater in whole blood than IMP on delayed HPLC. Early HPLC reveald no significant difference in composition of IMP, PIA, and PIB between the normal and ischemic hemispheres. Delayed HPLC revealed a greater proportion of PIA in the ischemic than the normal hemisphere, but this was not statistically significant. (N.K.)

Study of sup 123 I-IMP SPECT on diabetic patients

Energy Technology Data Exchange (ETDEWEB)

Kinoshita, Ikuo; Takeo, Goh; Iwanaga, Keisuke; Uotani, Shigeo; Nakamura, Minoru; Sohda, Masanori; Ohe, Haruto; Toshimitsu, Takashi; Ohe, Nobuharu (Yahata City Hospital, Kitakyushu, Fukuoka (Japan))

1991-07-01

The involvement of peripheral nerves and nerve roots often leads to neurological manifestations which have frequently been described in association with diabetes mellitus. Whether there is any specific involvement of the central nervous system in this process has yet to be determined. Recently, many reports have suggested that significant neurophysiologic abnormalities in the central nervous system can sometimes be found in diabetic patients. In order to accurately examine the existence of central nervous system involvement in patients with diabetes mellitus, comparisons of {sup 123}I-IMP (IMP) washout rates were made between normal adults (n=19, average age 43.3 years) and diabetic patients (n=23, average age 43.3 years), and these results were graphically demonstrated by color images. Early images were obtained 30 minutes after intravenous injection, while delayed images were made 4 hours after injection. The IMP washout rate was obtained by subtracting the values of the delayed image with the early image. The standard deviation (SD) of the IMP washout rate for each patient was compared to the averaged SD obtained from healthy adults. After calculating the deviation from SD levels of healthy adults, we made an image of the patient's IMP washout rates. These images were divided into seven degrees (I, II: normal, III, IV: borderline, V{approx}VII: abnormal) and the ratio of each degree was expressed by a histogram in each cerebral hemisphere as the washout rate index. In 23 diabetic subjects, seven patients were found to be borderline while sixteen patients were abnormal. These impairments were not related either to the presence of diabetic triopathy or the duration of disease. By utilising such a noninvasive method, we were able to accurately evaluate the extent of diabetic central neuropathy. Therefore this subtraction method, which uses the specificity of IMP SPECT, is thus considered to be highly useful for broad clinical application. (author).

IMP3 RNP Safe Houses Prevent miRNA-Directed HMGA2 mRNA Decay in Cancer and Development

Directory of Open Access Journals (Sweden)

Lars Jønson

2014-04-01

Full Text Available The IMP3 RNA-binding protein is associated with metastasis and poor outcome in human cancer. Using solid cancer transcriptome data, we found that IMP3 correlates with HMGA2 mRNA expression. Cytoplasmic IMP3 granules contain HMGA2, and IMP3 dose-dependently increases HMGA2 mRNA. HMGA2 is regulated by let-7, and let-7 antagomiRs make HMGA2 refractory to IMP3. Removal of let-7 target sites eliminates IMP3-dependent stabilization, and IMP3-containing bodies are depleted of Ago1-4 and miRNAs. The relationship between Hmga2 mRNA and IMPs also exists in the developing limb bud, where IMP1-deficient embryos show dose-dependent Hmga2 mRNA downregulation. Finally, IMP3 ribonucleoproteins (RNPs contain other let-7 target mRNAs, including LIN28B, and a global gene set enrichment analysis demonstrates that miRNA-regulated transcripts in general are upregulated following IMP3 induction. We conclude that IMP3 RNPs may function as cytoplasmic safe houses and prevent miRNA-directed mRNA decay of oncogenes during tumor progression.

Regional cerebral blood flow in various pediatric neurological patients using /sup 123/I-IMP SPECT

Energy Technology Data Exchange (ETDEWEB)

Konishi, Tohru; Naganuma, Yoshihiro; Hongou, Kazuhisa; Murakami, Miyako; Yamatani, Miwa; Okada, Toshio

1988-03-01

The recent development of a new radiopharmaceutical /sup 123/I-isopropyl-iodoamphetamine (IMP), which is taken up by the brain from the blood flow, has offered a possibility of constructing scintigraphy maps of regional cerebral blood flow (rCBF) using single photon emission CT. We used this mehtod in various pediatric neurological diseases. Six patients with cerebro-vascular disorders (moya-moya disease 2, infarction 3 and HHE syndrome 1), 6 patients with infectious diseases of CNS (acute encephalitis 4, septic meningitis 1 and SSPE 1) and a miscellaneous group of six patients were studied. The rCBF abnormalities in cerebro-vascular diseases were more extensive and frequent than x-ray CT abnormalities. Repeated studies of IMP-SPECT revealed usefulness for the understanding of changeable hemodynamic pathophysiology and for the judgment of theraptic effectiveness and prognosis. The rCBF decrease in infectious diseases tended to be more diffuse and slight than that in cerebro-vascular diseases. In almost all patients, the area of rCBF decrease coincided with the area of EEG slowing evaluated by EEG topographic analysis. Brain imaging using /sup 123/I-IMP SPECT may reveal functional abnormalities as well as organic lesions. /sup 123/I-IMP SPECT has introduced a new era for the useful application of nuclear medicine to the investigation of pediatric neurological diseases.

Dominance of IMP-4-Producing Enterobacter cloacae among Carbapenemase-Producing Enterobacteriaceae in Australia

Science.gov (United States)

Townell, Nicola; Nimmo, Graeme R.; George, Narelle M.; Robson, Jennifer; Vohra, Renu; Davis, Louise; Heney, Claire; Paterson, David L.

2015-01-01

The prevalence of carbapenemase-producing Enterobacteriaceae (CPE) has been increasing worldwide. blaIMP has been reported to be the predominant carbapenemase-encoding gene within Enterobacteriaceae in Australia. However, there are limited data currently available on CPE from Queensland, Australia. A total of 58 CPE isolates were isolated between July 2009 and March 2014 from Queensland hospitals. The clonality of isolates was determined by Diversilab repetitive sequence-based PCR. The isolates were investigated for the resistance mechanisms carbapenemase, extended-spectrum β-lactamase, and AmpC β-lactamase and for aminoglycoside resistance and plasmid-mediated quinolone resistance genes by PCR. The plasmid types associated with carbapenemase-encoding genes were characterized. The majority of the CPE were Enterobacter cloacae (n = 29). The majority of Queensland CPE isolates were IMP producers and comprised 11 species (n = 48). Nine NDM-producing Enterobacteriaceae were identified. One NDM-producing Klebsiella pneumoniae isolate coproduced OXA-48. One K. pneumoniae isolate was an OXA-181 producer. The incidence of IMP producers increased significantly in 2013. blaIMP-4 was found in all IMP-producing isolates. blaTEM, qnrB, and aacA4 were common among IMP-4 producers. The HI2 (67%) and L/M (21%) replicons were associated with blaIMP-4. All HI2 plasmids were of sequence type 1 (ST1). All but one of the NDM producers possessed blaCTX-M-15. The 16S rRNA methylase genes found among NDM producers were armA, rmtB, rmtC, and rmtF. The substantial increase in the prevalence of CPE in Queensland has been associated mainly with the emergence E. cloacae strains possessing HI2 plasmids carrying blaIMP-4 over the past 2 years. The importation of NDM producers and/or OXA-48-like producers in patients also contributed to the increased emergence of CPE. PMID:25918153

[sup 123]I-IMP SPECT studies in schizophrenia and atypical psychosis

Energy Technology Data Exchange (ETDEWEB)

Hayashi, Takuji; Suga, Hidemichi (Aichi Medical University, Nagakute (Japan))

1993-05-01

According to the classification of Mitsuda, 23 patients with endogenous psychosis aged 40 years or younger, presenting with hallucination and delusion, were classified as having schizophrenia (n=12) or atypical psychosis (n=11). These patients were studied by single photon emission computed tomography (SPECT) with N-isopropyl-p-I-123-iodoamphetamine (I-123 IMP). Sixteen healthy persons served as controls. Early and delayed SPECT images were obtained 30 min and 4 hr, respectively, after intravenous injection of I-123 IMP. The group of schizophrenic patients had markedly decreased uptake of I-123 in the basal ganglia, as well as the right temporal and left occipital areas on both early and delayed images. In the group of atypical psychosis patients, however, decreased uptake of I-123 was noted in both the right basal ganglia and left occipital area on early images, but none of such findings were seen on delayed images. Regarding the uptake ratio in the frontal area on both early and delayed images, there were significant differences between the two groups. These findings have important implications for the different etiology of both disease types: not only functional disturbance in the frontal area but also irreversible changes may be involved in the occurrence of schizophrenia, and functional disturbance particularly in the right basal ganglia may be involved in the occurrence of atypical psychosis. (N.K.).

IMP3 RNP safe houses prevent miRNA-directed HMGA2 mRNA decay in cancer and development

DEFF Research Database (Denmark)

Jønson, Lars; Christiansen, Jan; Hansen, Thomas van Overeem

2014-01-01

by let-7, and let-7 antagomiRs make HMGA2 refractory to IMP3. Removal of let-7 target sites eliminates IMP3-dependent stabilization, and IMP3-containing bodies are depleted of Ago1-4 and miRNAs. The relationship between Hmga2 mRNA and IMPs also exists in the developing limb bud, where IMP1-deficient...... that IMP3 RNPs may function as cytoplasmic safe houses and prevent miRNA-directed mRNA decay of oncogenes during tumor progression....

Quantitative 123I IMP and 99mTc HMPAO imaging in the dog following cocaine administration

International Nuclear Information System (INIS)

Susskind, Herbert; Weber, David A.; Ivanovic, Marija; Wong, Christopher T.C.; Haan, Constance E. de; Gavin, Patrick R.

1996-01-01

SPECT and associated imaging procedures were used in beagle dogs to evaluate the uptake, distribution, and clearance properties of i.v.-injected 123 I IMP (IMP) and 99m Tc HMPAO (HMPAO) in the brain, lungs, liver, and kidneys; (2) quantify the acute effects (after 15 sec) of very low doses (0.5 or 1.0 mg/kg) cocaine on the kinetics and localization properties of IMP and HMPAO; and (3) evaluate comparative imaging properties of IMP and HMPAO for measuring regional cerebral blood flow (rCBF). Regional and global uptake and localization of IMP or HMPAO were evaluated in control studies using dynamic planar (0-30 min) and SPECT imaging (at 35 min). The regional distribution properties of IMP and HMPAO in the brain were estimated from regions of interest (ROIs) drawn around anatomic structures on MR slices and manually registered with corresponding SPECT slices. Cocaine significantly reduced the 30-min IMP uptake in the brain and lungs by ∼15%, but only slightly changed HMPAO uptake in the brain and other organs. In the control studies, the respective uptakes of IMP in the brain and lungs were 9 and 39% greater (p < 0.01) than those of HMPAO. In control SPECT studies, the highest uptake of IMP was observed in the thalamus and progressively less activity was observed in the parietal lobe, frontal lobe, cerebellum, occipital lobe, and entire brain; activity in the olfactory bulb was lower than in all other regions. Cocaine reduced IMP uptake in the cerebellum (p < 0.01), occipital lobe (p < 0.01), and entire brain (p < 0.05). IMP uptake (cpm/pixel-mCi) in the different brain regions was 1.3 to 2.1 times greater than that of HMPAO (p < 0.001). HMPAO uptake was more homogeneous throughout the gray matter of the brain; no significant uptake differences were observed among flagged regions. Results indicate that single, acute doses of cocaine, 0.5 and 1.0 mg/kg, significantly altered the uptake and localization properties of IMP in the dog's brain, lungs, liver, and kidneys

First half 2006 financial results; Resultats du 1er semestre 2006 Groupe Areva

Energy Technology Data Exchange (ETDEWEB)

NONE

2006-09-15

Areva provides technological solutions for highly reliable nuclear power generation and electricity transmission and distribution. The group is the world leader in nuclear power and the only company to cover all industrial activities in this field. This Press release presents the first half 2006 financial results: the overall performance and the performance by division (front end, reactors and services, back end, transmission and distribution). (A.L.B.)

Serial lung imaging with 123I-IMP in localized pulmonary lesions

International Nuclear Information System (INIS)

Nakajo, Masayuki; Shimada, Jurio; Shimozono, Michiko; Uchiyama, Noriaki; Hiraki, Yoshiyuki; Shinohara, Shinji.

1988-01-01

123 I-IMP (N-isopropyl-p-[ 123 I]-iodoamphetamine) dynamic (1 frame/min for 25 mins), 30-min and 4-hr static lung imaging was performed in a total of 65 patients with roentgenographic evidence of localized pulmonary lesion (12 with pneumonia, one with lung abscess, 5 with pulmonary tuberculosis, 3 with pneumoconiosis, one with lung fluke disease and 43 with various histological types of primary lung cancer). The findings in 65 of 70 (95 %) lesions in the initial 1 or 2-min dynamic 123 I-IMP images were analogous to those obtained by 99m Tc-MAA lung perfusion imaging and decreased activity was observed in 68 of 70 (97 %) lesions, suggesting that the initial images mainly reflected the relative distribution of pulmonary arterial blood flow. However, 123 I-IMP accumulated differently according to the pathological conditions afterwards. Decrease activity from 123 I-IMP was contineously observed in a cavity of the lung abscess, 2 of 2 tuberculomas, 3 of 7 large nodules of pneumoconiosis and all of the 42 cancerous lesions which were possible to be evaluated. Gradual increased in activity relative to that of ''normal lung fields'' was observed in all 14 lesions of pneumonia; pneumonic lesions of the lung abscess, tuberculosis and lung fluke disease; 4 of 7 large nodules of pneumoconiosis; all of 8 atelectatic lesions and 32 of 44 areas surrounding cancers (most of them had roentgenographic evidence of infiltrating shadows). Thus 123 I-IMP accumulated increasingly in pneumonic and atelectatic lesions, while it appeared not to accumulate in such lesions replacing lung tissues as cavity, caseous and fibrous lesions and primary lung cancers. 123 I-IMP can be used as a new lung imaging agent to provide diagnostic informations on the property of pulmonary lesions. (author)

Annual Report 1984. Chemistry Department

DEFF Research Database (Denmark)

Funck, Jytte; Nielsen, Ole John

This report contains a brief survey of the main activities in the Chemistry Department. All articles and reports published and lectures given in 1984 are presented. The facilities and equipment are mentioned briefly. The activities are divided into the following groups: radioisotope chemistry, an......, analytical- and organic chemistry, environmental chemistry, polymer chemistry, geochemistry and waste disposal, radical chemistry, positron annihilation, mineral processing, and general.......This report contains a brief survey of the main activities in the Chemistry Department. All articles and reports published and lectures given in 1984 are presented. The facilities and equipment are mentioned briefly. The activities are divided into the following groups: radioisotope chemistry...

cIMP synthesized by sGC as a mediator of hypoxic contraction of coronary arteries.

Science.gov (United States)

Chen, Zhengju; Zhang, Xu; Ying, Lei; Dou, Dou; Li, Yanhui; Bai, Yun; Liu, Juan; Liu, Limei; Feng, Han; Yu, Xiaoxing; Leung, Susan Wai-Sum; Vanhoutte, Paul M; Gao, Yuansheng

2014-08-01

cGMP is considered the only mediator synthesized by soluble guanylyl cyclase (sGC) in response to nitric oxide (NO). However, purified sGC can synthesize several other cyclic nucleotides, including inosine 3',5'-cyclic monophosphate (cIMP). The present study was designed to determine the role of cIMP in hypoxic contractions of isolated porcine coronary arteries. Vascular responses were examined by measuring isometric tension. Cyclic nucleotides were assayed by HPLC tandem mass spectroscopy. Rho kinase (ROCK) activity was determined by measuring the phosphorylation of myosin phosphatase target subunit 1 using Western blot analysis and an ELISA kit. The level of cIMP, but not that of cGMP, was elevated by hypoxia in arteries with, but not in those without, endothelium [except if treated with diethylenetriamine (DETA) NONOate]; the increases in cIMP were inhibited by the sGC inhibitor 1H-[1,2,4]oxadiazolo[4,3,-a]quinoxalin-1-one (ODQ). Hypoxia (Po2: 25-30 mmHg) augmented contractions of arteries with and without endothelium if treated with DETA NONOate; these hypoxic contractions were blocked by ODQ. In arteries without endothelium, hypoxic augmentation of contraction was also obtained with exogenous cIMP. In arteries with endothelium, hypoxic augmentation of contraction was further enhanced by inosine 5'-triphosphate, the precursor for cIMP. The augmentation of contraction caused by hypoxia or cIMP was accompanied by increased phosphorylation of myosin phosphatase target subunit 1 at Thr(853), which was prevented by the ROCK inhibitor Y-27632. ROCK activity in the supernatant of isolated arteries was stimulated by cIMP in a concentration-dependent fashion. These results demonstrate that cIMP synthesized by sGC is the likely mediator of hypoxic augmentation of coronary vasoconstriction, in part by activating ROCK. Copyright © 2014 the American Physiological Society.

1984 Act on nuclear activities (1984:3)

International Nuclear Information System (INIS)

1984-01-01

This 1984 Act on Nuclear Activities (1984:3) replaces the 1956 Atomic Energy Act as well as the 1977 Act on special permits to charge nuclear reactors with nuclear fuel and the 1980 Act on Public Insight into the Safety Work at Nuclear Power Plants. Like the 1956 Act, the 1984 Act in a safety legislation, which is based on a system of licensing conditions and supervision. According to the fundamental provisions of the 1984 Act, nuclear activities should be conducted in such a way as to meet safety requirements and fulfil the obligations that follow from Sweden's international agreements for the purpose of preventing the proliferation of nuclear weapons. (NEA) [fr

Brain scintigraphy with N-isopropyl [123I] p-iodoamphetamine (123I IMP) in patients with various cerebral diseases

International Nuclear Information System (INIS)

Oshibuchi, Masao; Kanda, Teturo; Sato, Mitutaka; Miyagi, Jun; Ohtake, Hisasi; Suhara, Tetuya; Mori, Atuyoshi.

1988-01-01

Single photon emission computed tomography(SPECT) with N-isopropyl-p-[ 123 I]-iodoamphet amine(IMP) was utilized in 99 patients with various cerebral diseases and 3 healthy volunteers. By IMP SPECT, demaged area was observed as wider and faster in time than with X-ray CT or MRI. The nidus was visualized as defect of IMP in cases of AVM. In patients with subarachnoid hemorrhage, IMP SPECT was more useful for detecting of post hemorrhagic symptomatic vasospasm compared to X-ray CT or MRI. IMP SPECT was also useful to the differential diagnosis in cases of dementia. Grossed cerebellar diaschisis(CCD) was observed in 26 out of 67 cases (39 %) studied. In epilepsy the low uptake areas of IMP in the bilateral occipital lobes were observed in IMP SPECT. (author)

Imp2 regulates GBM progression by activating IGF2/PI3K/Akt pathway.

Science.gov (United States)

Mu, Qingchun; Wang, Lijun; Yu, Fengbo; Gao, Haijun; Lei, Ting; Li, Peiwen; Liu, Pengfei; Zheng, Xu; Hu, Xitong; Chen, Yong; Jiang, Zhenfeng; Sayari, Arash J; Shen, Jia; Huang, Haiyan

2015-01-01

Glioblastomas multiforme (GBM) are the most frequently occurring malignant brain cancers. Treatment for GBM consists of surgical resection and subsequent adjuvant radiation therapy and chemotherapy. Despite this, GBM patient survival is limited to 12-15 months, and researchers are continually trying to develop improved therapy options. Insulin-like growth factor 2 mRNA-binding protein 2 (Imp2) is known to be upregulated in many cancers and is known to regulate the signaling activity of insulin-like growth factor 2 (IGF2). However, relatively little is known about its role in malignant development of GBM. In this study, we first found Imp2 is upregulated in GBM tissues by using clinical samples and public database search. Studies with loss and gain of Imp2 expression in in vitro GBM cell culture system demonstrated the role of Imp2 in promoting GBM cell proliferation, migration, invasion and epithelial-to-mesenchymal transition (EMT). Additionally, our results show that Imp2 regulates the activity of IGF2, which further activates PI3K/Akt signaling, thereby to promote GBM malignancy. Inhibition of Imp2 was also found to sensitize GBM to temozolomide treatment. These observations add to the current knowledge of GBM biology, and may prove useful in development of more effective GBM therapy.

123I-IMP-SPECT in vascular dementia

International Nuclear Information System (INIS)

Namura, Yasuhiro; Miyoshi, Toshihiko; Shio, Hideo; Yamaguchi, Shinya; Kimura, Jun

1990-01-01

Cerebral blood flow (CBF) was studied by N-isopropyl-p- 123 I-iodoamphetamine (IMP)-single photon emission computed tomography (SPECT) in patients with vascular dementia. Patients were divided by CT/MRI findings into multiple or localized type and cortical or subcortical type. Of patients with multiple lesions in the cortex, the reduction of CBF was noted in several cortex corresponding to CT/MRI findings. Patients in this group had a high incidence of aphasia, agraphia, dyscalculia, and amnesia. Patients with multiple lesions in the white matter and basal ganglia were subdivided into 3 groups by clinical manifestations. CBF in those with dementia showed generalized reduction in all cerebral cortex and especially in bilateral frontal regions. CBF in those with slightly impaired mentality was almost normal. In another group with pseudobulbar palsy and/or extrapyramidal sings, CBF was reduced intermediately only in bilateral frontal regions. Typical symptoms in demented patients were apathy, emotional lability, and forgetfulness. In those with the localized type, CBF was reduced in cerebral cortical areas correlating with the impaired mental functions. (author)

Study on the primary visual cortex of visually impaired subjects by means of 123I-IMP SPECT and MRI

International Nuclear Information System (INIS)

Ishikawa, Nobuyoshi; Satou, Motohiro; Takeda, Tohoru; Itai, Yuji; Nishijo, Kazushi.

1995-01-01

We conducted a study of rCBF in the primary visual cortex of visually impaired subjects who have not been subjected to external stimulation for a long period, by means of 123 I-IMP SPECT and MRI. The four subjects had lost their sight due to brain tumors (n=2), glaucoma (n=1) and trauma (n=1). 123 I-IMP SPECT showed no differences between the visually impaired group and a visually sound control group on visual analysis as well as semiquantitative analysis. MRI of the visually impaired subjects showed no organic changes, such as atrophy, in the occipital cortex. In conclusion, visually impaired subjects have no decrease in rCBF and no anatomical changes in the primary visual cortex. (author)

Serial lung imaging with /sup 123/I-IMP in localized pulmonary lesions

Energy Technology Data Exchange (ETDEWEB)

Nakajo, Masayuki; Shimada, Jurio; Shimozono, Michiko; Uchiyama, Noriaki; Hiraki, Yoshiyuki; Shinohara, Shinji.

1988-05-01

/sup 123/I-IMP (N-isopropyl-p-(/sup 123/I)-iodoamphetamine) dynamic (1 frame/min for 25 mins), 30-min and 4-hr static lung imaging was performed in a total of 65 patients with roentgenographic evidence of localized pulmonary lesion (12 with pneumonia, one with lung abscess, 5 with pulmonary tuberculosis, 3 with pneumoconiosis, one with lung fluke disease and 43 with various histological types of primary lung cancer). The findings in 65 of 70 (95 %) lesions in the initial 1 or 2-min dynamic /sup 123/I-IMP images were analogous to those obtained by /sup 99m/Tc-MAA lung perfusion imaging and decreased activity was observed in 68 of 70 (97 %) lesions, suggesting that the initial images mainly reflected the relative distribution of pulmonary arterial blood flow. However, /sup 123/I-IMP accumulated differently according to the pathological conditions afterwards. Decrease activity from /sup 123/I-IMP was contineously observed in a cavity of the lung abscess, 2 of 2 tuberculomas, 3 of 7 large nodules of pneumoconiosis and all of the 42 cancerous lesions which were possible to be evaluated. Gradual increased in activity relative to that of ''normal lung fields'' was observed in all 14 lesions of pneumonia; pneumonic lesions of the lung abscess, tuberculosis and lung fluke disease; 4 of 7 large nodules of pneumoconiosis; all of 8 atelectatic lesions and 32 of 44 areas surrounding cancers (most of them had roentgenographic evidence of infiltrating shadows). Thus /sup 123/I-IMP accumulated increasingly in pneumonic and atelectatic lesions, while it appeared not to accumulate in such lesions replacing lung tissues as cavity, caseous and fibrous lesions and primary lung cancers. /sup 123/I-IMP can be used as a new lung imaging agent to provide diagnostic informations on the property of pulmonary lesions.

Distinct Signaling Roles of cIMP, cCMP, and cUMP.

Science.gov (United States)

Seifert, Roland

2016-10-04

The cyclic purine nucleotide cIMP and the cyclic pyrimidine nucleotides cCMP and cUMP are emerging second messengers. These cNMPs show different biological effects, but the molecular mechanisms remain elusive. In this issue of Structure, Ng et al. (2016) provide structural evidence for distinct interactions of cIMP, cCMP, and cUMP with ion channels. Copyright © 2016 Elsevier Ltd. All rights reserved.

Integrated Micro-Power System (IMPS) Development at NASA Glenn Research Center

Science.gov (United States)

Wilt, David; Hepp, Aloysius; Moran, Matt; Jenkins, Phillip; Scheiman, David; Raffaelle, Ryne

2003-01-01

Glenn Research Center (GRC) has a long history of energy related technology developments for large space related power systems, including photovoltaics, thermo-mechanical energy conversion, electrochemical energy storage. mechanical energy storage, power management and distribution and power system design. Recently, many of these technologies have begun to be adapted for small, distributed power system applications or Integrated Micro-Power Systems (IMPS). This paper will describe the IMPS component and system demonstration efforts to date.

Comparison of I-123 IMP cerebral uptake and MR spectroscopy following experimental carotid occlusion

International Nuclear Information System (INIS)

Holman, B.L.; Jolesz, F.A.; Polak, J.F.; Kronauge, J.F.; Adams, D.F.

1985-01-01

Both I-123 IMP scintigraphy and MRI have been suggested as sensitive detectors of changes shortly after acute cerebral infarction. We compared the uptake of N-isopropyl I-123 p-iodoamphetamine (IMP) and MR spectroscopy of the brain after internal carotid artery ligation. Thirteen gerbils were lightly anesthetized with ether. After neck dissection, an internal carotid artery was occluded. After 2.8 hours, 100 muCi I-123 IMP was injected intravenously into the 13 experimental animals plus three controls. Seven gerbils remained asymptomatic while six developed hemiparesis. At 3 hours after ligation, the animals were killed. The brains were bisected and T1 and T2 relaxation times were determined for the right and left hemispheres by MR spectroscopy immediately after dissection. I-123 IMP uptake was then determined in the samples. Interhemispheric differences in uptake for I-123 IMP were 0.1 +/- 1.7% (SEM) in the control, 33.5 +/- 10% in the asymptomatic and 54.6 +/- 9.7% in the symptomatic animals. Significant differences were seen with I-123 IMP in 6/7 asymptomatic and 6/6 symptomatic animals. In conclusion, I-123 is more sensitive than T1 or T2 relaxation times for the detection of cerebral perfusion abnormalities. Prolongation in T1 and T2 relaxation times correlates closely with increased brain tissue water content and the development of symptoms, indicators of structural brain damage and probable infarction

IMP: Using microsat technology to support engineering research inside of the International Space Station

Science.gov (United States)

Carroll, Kieran A.

2000-01-01

This paper describes an International Space Station (ISS) experiment-support facility being developed by Dynacon for the Canadian Space Agency (CSA), based on microsatellite technology. The facility is called the ``Intravehicular Maneuverable Platform,'' or IMP. The core of IMP is a small, free-floating platform (or ``bus'') deployed inside one of the pressurized crew modules of ISS. Exchangeable experimental payloads can then be mounted to the IMP bus, in order to carry out engineering development or demonstration tests, or microgravity science experiments: the bus provides these payloads with services typical of a standard satellite bus (power, attitude control, etc.). The IMP facility takes advantage of unique features of the ISS, such as the Shuttle-based logistics system and the continuous availability of crew members, to greatly reduce the expense of carrying out space engineering experiments. Further cost reduction has been made possible by incorporating technology that Dynacon has developed for use in a current microsatellite mission. Numerous potential payloads for IMP have been identified, and the first of these (a flexible satellite control experiment) is under development by Dynacon and the University of Toronto's Institute for Aerospace Studies, for the CSA. .

Podiel osobností na vývoji profesionálnej hudobnej kultúry. K pocte Alexandra Moyzesa (1906–1984) a Ludovíta Rajtera (1906–2000). Muzikologická konferencia s medzinárodnou účasťou, Bratislava 4.–6. 10. 2006

Czech Academy of Sciences Publication Activity Database

Gabrielová, Jarmila

2007-01-01

Roč. 44, č. 2 (2007), s. 193-194 ISSN 0018-7003. [Podiel osobností na vývoji profesionálnej hudobnej kultúry. K pocte Alexandra Moyzesa (1906–1984) a Ludovíta Rajtera (1906–2000). Bratislava, 04.10.2006–06.10.2006] Institutional research plan: CEZ:AV0Z90580513 Keywords : professional music culture * Alexander Moyzes * Ludovit Rajter Subject RIV: AL - Art, Architecture, Cultural Heritage

A comparison among 123I-IMP SPECT, EEG and MRI in patients with temporal lobe epilepsy

International Nuclear Information System (INIS)

Tatsu, Yoshimitsu; Nishigaki, Hiroshi; Adachi, Itaru

1994-01-01

N-isopropyl-p-[ 123 I]iodoamphetamine ( 123 I-IMP) single photon emission computed tomography (SPECT), electroencephalography (EEG), and magnetic resonance imaging (MRI) were performed in 19 patients with temporal lobe epilepsy during interictal stage. MRI demonstrated abnormal signal in mesial temporal lobe (hippocampus) in 10 of 19 patients and 123 I-IMP SPECT showed a hypoperfusion area in 15 of 19 patients. When compared with EEG and MRI data, disagreement of the affected area was observed in 3 cases. In comparison of EEG and 123 I-IMP SPECT data, disagreement of the affected area was observed in 6 cases. Although there was no disagreement in comparison of MRI and 123 I-IMP SPECT. We made a reprojection data parallel to the hippocampus in 123 I-IMP SPECT. These data demonstrated obviously a hypoperfusion area around the hippocampus. In cases within one month from seizure attack, wide hypoperfusion area was showed on 123 I-IMP SPECT in comparison of abnormal signal area on MRI. It could be considered that a reprojection data parallel to the hippocampus was useful to know extent of hypoperfusion area in temporal lobe epilepsy. (author)

Development of selective medium for IMP-type carbapenemase-producing Enterobacteriaceae in stool specimens.

Science.gov (United States)

Yamamoto, Norihisa; Kawahara, Ryuji; Akeda, Yukihiro; Shanmugakani, Rathina Kumar; Yoshida, Hisao; Hagiya, Hideharu; Hara, Naohiro; Nishi, Isao; Yukawa, Satomi; Asada, Rumiko; Sasaki, Yumi; Maeda, Kazuhiro; Sakamoto, Noriko; Hamada, Shigeyuki; Tomono, Kazunori

2017-03-24

Identification of carbapenemase-producing Enterobacteriaceae (CPE) in faecal specimens is challenging. This fact is particularly critical because low-level carbapenem-resistant organisms such as IMP-producing CPE are most prevalent in Japan. We developed a modified selective medium more suitable for IMP-type CPE. Fifteen reference CPE strains producing different types of β-lactamases were used to evaluate the commercially available CHROMagar KPC and chromID CARBA as well as the newly prepared MC-ECC medium (CHROMagar ECC supplemented with meropenem, cloxacillin, and ZnSO 4 ) and M-ECC medium (CHROMagar ECC supplemented with meropenem and ZnSO 4 ). A total of 1035 clinical samples were then examined to detect CPE using chromID CARBA and M-ECC medium. All tested strains producing NDM-, KPC-, and OXA-48-carbapenemases were successfully cultured in the media employed. Although most of the IMP-positive strains did not grow in CHROMagar KPC, chromID CARBA, or MC-ECC, all tested strains grew on M-ECC. When faecal samples were applied to the media, M-ECC medium allowed the best growth of IMP-type CPE with a significantly higher sensitivity (99.3%) than that of chromID CARBA (13.9%). M-ECC medium was determined as the most favourable selective medium for the detection of IMP-type CPE as well as other types of CPE.

IMP-27, a Unique Metallo-β-Lactamase Identified in Geographically Distinct Isolates of Proteus mirabilis.

Science.gov (United States)

Dixon, Nyssa; Fowler, Randal C; Yoshizumi, A; Horiyama, Tsukasa; Ishii, Y; Harrison, Lucas; Geyer, Chelsie N; Moland, Ellen Smith; Thomson, Kenneth; Hanson, Nancy D

2016-10-01

A novel metallo-β-lactamase gene, blaIMP-27, was identified in unrelated Proteus mirabilis isolates from two geographically distinct locations in the United States. Both isolates harbor blaIMP-27 as part of the first gene cassette in a class 2 integron. Antimicrobial susceptibility testing indicated susceptibility to aztreonam, piperacillin-tazobactam, and ceftazidime but resistance to ertapenem. However, hydrolysis assays indicated that ceftazidime was a substrate for IMP-27. Copyright © 2016 Dixon et al.

Evaluation of newborns with brain disease using 123I-IMP SPECT

International Nuclear Information System (INIS)

Oshima, Motoo; Yasukochi, Hiroshi; Suzuki, Chizuko; Sasaki, Junko; Kitoh, Osamu.

1993-01-01

Eleven newborns with suspected cerebral disease were evaluated using 123 I-IMP SPECT. In a normal subject, high uptake was shown in the sensorimotor cortex, thalamus, midbrain-brainstem, and cerebellar vermis. Decreased perfusion was also noted in the frontal lobe. In hypoxic ischemic encephalopathy (HIE), diffuse decreased uptake which showed no redistribution in the white matter was seen in two patients. These two patients had a poor prognosis. In one of the other 4 patients with HIE, persistent defect in parasagittal area was recognized and the patient also had a poor prognosis. In one of two patients with tuberous sclerosis, 123 I-IMP SPECT showed high uptake in the area of increased density shown in CT. Thus, 123 I-IMP SPECT of newborn has characteristic findings different from the adult. This tracer also might have a prognostic value of clinical improvement following HIE. (author)

I-123 IMP brain scintigraphies in asphyxiated newborns

International Nuclear Information System (INIS)

Maeda, Hisatoshi; Konishi, Yukuo; Kuriyama, Masanori; Ishii, Yasushi; Sudo, Masakatsu

1987-01-01

Brain scintigraphies with N-Isopropyl (I-123) p-Iodoamphetamine (I-123 IMP) were conducted in eight patients who had asphyxia at the time of birth. Two patients, 15 and 26 year-old, had local defects and diffuse low cerebral uptakes. Two children, 70 day and 2 year-old, had no cerebral uptake. Brain scintigraphies were carried out twice in three among four newborns. Only slight I-123 IMP brain uptakes were observed in the first 10 days. The lateral views of the brain scintigraphies showed increased uptake in the middle region of the brain between 10 to 30 days and reached almost equally distributed in frontal, middle and posterior regions after 30 days. These results were thought to represent rather developmental changes of the cerebral blood flow after ischemic attacks at birth. (author)

mTOR complex 2 phosphorylates IMP1 cotranslationally to promote IGF2 production and the proliferation of mouse embryonic fibroblasts

DEFF Research Database (Denmark)

Dai, Ning; Christiansen, Jan; Nielsen, Finn

2013-01-01

uncover a new mechanism by which mTOR regulates organismal growth by promoting IGF2 production in the mouse embryo through mTORC2-catalyzed cotranslational IMP1/IMP3 phosphorylation. Inasmuch as TORC2 is activated by association with ribosomes, the present results indicate that mTORC2-catalyzed...... production, and diminished proliferation. The proliferation of the IMP1-null fibroblasts can be restored to wild-type levels by IGF2 in vitro or by re-expression of IMP1, which corrects the defects in IGF2 RNA splicing and translation. The ability of IMP1 to correct these defects is dependent on IMP1...

IMP2, a nuclear gene controlling the mitochondrial dependence of galactose, maltose and raffinose utilization in Saccharomyces cerevisiae.

Science.gov (United States)

Donnini, C; Lodi, T; Ferrero, I; Puglisi, P P

1992-02-01

The IMP2 gene of Saccharomyces cerevisiae is involved in the nucleo-mitochondrial control of maltose, galactose and raffinose utilization as shown by the inability of imp2 mutants to grow on these carbon sources in respiratory-deficient conditions or in the presence of ethidium bromide and erythromycin. The negative phenotype cannot be scored in the presence of inhibitors of respiration and oxidative phosphorylation, indicating that the role of the mitochondria in the utilization of the above-mentioned carbon sources in imp2 mutants is not at the energetical level. Mutations in the IMP2 gene also confer many phenotypic alterations in respiratory-sufficient conditions, e.g. leaky phenotype on oxidizable carbon sources, sensitivity to heat shock and sporulation deficiency. The IMP2 gene has been cloned, sequenced and disrupted. The phenotype of null imp2 mutants is indistinguishable from that of the originally isolated mutant.

Oncofetal Protein IMP3: A Novel Molecular Marker That Predicts Metastasis of Papillary and Chromophobe Renal Cell Carcinomas

Science.gov (United States)

Jiang, Zhong; Lohse, Christine M.; Chu, Peigou G.; Wu, Chin-Lee; Woda, Bruce A.; Rock, Kenneth L.; Kwon, Eugene D.

2009-01-01

BACKGROUND Whether an oncofetal protein, IMP3, can serve as a prognostic biomarker to predict metastasis for patients with localized papillary and chromophobe subtypes of renal cell carcinomas (RCCs) was investigated. METHODS The expression of IMP3 in 334 patients with primary papillary and chromophobe RCC from multiple medical centers was evaluated by immunohistochemistry. The 317 patients with localized papillary and chromophobe RCCs were further evaluated for outcome analyses. RESULTS IMP3 was significantly increased in a subset of localized papillary and chromophobe RCCs that subsequently metastasized. Patients with localized IMP3-positive tumors (n = 33; 10%) were over 10 times more likely to metastasize (risk ratio [RR], 11.38; 95% confidence interval [CI], 5.40–23.96; P <.001) and were nearly twice as likely to die (RR, 1.91; 95% CI, 1.13–3.22; P =.016) compared with patients with localized IMP3 negative tumors. The 5-year metastasis-free and overall survival rates were 64% and 58% for patients with IMP3-positive localized papillary and chromophobe RCCs compared with 98% and 85% for patients with IMP3 negative tumors, respectively. In multivariable analysis adjusting for the TNM stage and nuclear grade, patients with IMP3-positive tumors were still over 10 times more likely to progress to distant metastasis (RR, 13.45; 95% CI, 6.00–30.14; P <.001) and were still nearly twice as likely die (RR, 1.95; 95% CI, 1.15–3.31; P =.013) compared with patients with IMP3-negative tumors. CONCLUSIONS IMP3 is an independent prognostic biomarker that can be used to identify a subgroup of patients with localized papillary and chromophobe RCC who are at high risk for developing distant metastasis. PMID:18412154

A Preliminary Version of Heavy Ion Treatment Planning System at IMP

International Nuclear Information System (INIS)

Liu Xinguo; Dai Zhongying; Ye Fei; Wu Qingfeng; Li Ping; Li Qiang; Jin Xiaodong; Du Xiaogang; WangYangping; Dang Jianwu

2010-01-01

Based on the Heavy Ion Research Facility in Lanzhou (HIRFL/HIRFL-CSR), clinical trials of heavy ion radiotherapy are being conducted at the Institute of Modern Physics (IMP), Chinese Academy of Sciences, where two-dimensional(2D) layer-stacking conformal irradiation method in a passive beam delivery system was applied. To make better use of the biophysical advantages of heavy ion beams and ensure success of the clinical trials, a preliminary version of heavy ion treatment planning system (TPS) has been developed at IMP. The TPS was designed in a manner to adapt to the 2D layer-stacking conformal irradiation method. The architecture and function of the TPS software and the implementation of dose calculation algorithm in the TPS were introduced in this paper.The deviation between the doses planned by the TPS and measured through an anthropomorphous phantom was verified to be less than 5%. Finally,the pending issues for developing a sophisticated treatment planning system at IMP were discussed. (authors)

2. Report: 1 January 1984 - 31 December 1984

International Nuclear Information System (INIS)

1985-01-01

During 1984 the Licensing Branch of the Atomic Energy Corporation submitted recommendations in connection with the commissioning of Unit 1 of the Koeberg reactor. In March 1984 initial criticality and the low power testing phase were recommended. In August 1984 full commercial operation of the Unit 1 reactor was permitted. The Council received a presentation on the criteria adopted for the selection of the Vaalputs waste disposal facility. The Council also received presentations giving the criteria which would be adopted in the selection of suitable sites for possible future nuclear power stations

sup 123 I-IMP-SPECT in vascular dementia

Energy Technology Data Exchange (ETDEWEB)

Namura, Yasuhiro; Miyoshi, Toshihiko; Shio, Hideo; Yamaguchi, Shinya; Kimura, Jun (Kyoto Univ. (Japan). Hospital)

1990-12-01

Cerebral blood flow (CBF) was studied by N-isopropyl-p-{sup 123}I-iodoamphetamine (IMP)-single photon emission computed tomography (SPECT) in patients with vascular dementia. Patients were divided by CT/MRI findings into multiple or localized type and cortical or subcortical type. Of patients with multiple lesions in the cortex, the reduction of CBF was noted in several cortex corresponding to CT/MRI findings. Patients in this group had a high incidence of aphasia, agraphia, dyscalculia, and amnesia. Patients with multiple lesions in the white matter and basal ganglia were subdivided into 3 groups by clinical manifestations. CBF in those with dementia showed generalized reduction in all cerebral cortex and especially in bilateral frontal regions. CBF in those with slightly impaired mentality was almost normal. In another group with pseudobulbar palsy and/or extrapyramidal sings, CBF was reduced intermediately only in bilateral frontal regions. Typical symptoms in demented patients were apathy, emotional lability, and forgetfulness. In those with the localized type, CBF was reduced in cerebral cortical areas correlating with the impaired mental functions. (author).

Clinical research on quantitative imaging of cerebral blood flow using 123I-IMP

International Nuclear Information System (INIS)

Kinoshita, Hirofumi

1987-01-01

Cerebral blood flow measurement was performed using N-Isopropyl-p-( 123 I)-Iodoam-phetamine (IMP) and rotating gammacamera emission computed tomography (ECT), and a new quantitative profile curve was designed. There was a good correlation between the cerebral blood flow measured by intravenous Xe-133 method and that measured by IMP method in ten normal volunteers. IMP-ECT was performed in 40 patients with various cerebral diseases. The following results were obtained: 1. Minimum recognizable cerebral blood flow difference was 5 ml/100 g/min. 2. Quantitative redistribution was observed in approximately half of the cases which showed qualitative redistribution. 3. The incidence of crossed cerebellar diaschiasis was high among patients with significant cerebral disease (8 cases/10 cases). (author)

Study on uptake and dynamics of [sup 123]I-IMP in pulmonary diseases

Energy Technology Data Exchange (ETDEWEB)

Taguchi, Masato (Kagoshima Univ. (Japan). Faculty of Medicine)

1992-11-01

The aim of this study was to assess serial uptake of N-isopropyl-p-[I-123] iodoamphetamine (I-123 IMP) quantitatively in the lung. A total of 53 patients were enrolled in the study, consisting of 34 with lung cancer, 12 with inflammatory disease and 7 with miscellaneous diseases. The findings were compared with those with [sup 99m]Tc-MAA. The 1- or 2-min I-123 IMP images were analogous to those of [sup 99m]Tc-MAA in 24 patients. Early I-132 IMP images seemed to be governed by pulmonary arterial blood flow. I-123 IMP was not taken up by cancerous lesions of the lung on both 30 min and 4 hr images. Nor was it taken up by other malignancy. It was taken up by all inflammatory lesions, including pneumonia and infiltrate surrounding lung abscess. Collapse lesions were shown as warm or cold areas on 30 min images and as hot spots on 4 hr images. IMP was not taken up by pleural effusions. Pulmonary arterial blood flow was shown as cold areas at 30 min, and as warm or cold areas at 4 hr. In conclusion, intrathoracic cancerous lesions, cavities and pleural effusions were shown as cold areas on both early and delayed images. Both inflammatory and collapse lesions were shown as hot areas on delayed images. Quantitative assessment of the lesion/contralateral lung count ratios suggested different mechanism in tracer uptake: delayed clearance and delayed fill-in may be involved in the mechanism for inflammation and collapse, respectively. (N.K.).

Evaluation of newborns with brain disease using [sup 123]I-IMP SPECT

Energy Technology Data Exchange (ETDEWEB)

Oshima, Motoo; Yasukochi, Hiroshi (Teikyo Univ., Tokyo (Japan). Faculty of Medicine); Suzuki, Chizuko; Sasaki, Junko; Kitoh, Osamu

1993-07-01

Eleven newborns with suspected cerebral disease were evaluated using [sup 123]I-IMP SPECT. In a normal subject, high uptake was shown in the sensorimotor cortex, thalamus, midbrain-brainstem, and cerebellar vermis. Decreased perfusion was also noted in the frontal lobe. In hypoxic ischemic encephalopathy (HIE), diffuse decreased uptake which showed no redistribution in the white matter was seen in two patients. These two patients had a poor prognosis. In one of the other 4 patients with HIE, persistent defect in parasagittal area was recognized and the patient also had a poor prognosis. In one of two patients with tuberous sclerosis, [sup 123]I-IMP SPECT showed high uptake in the area of increased density shown in CT. Thus, [sup 123]I-IMP SPECT of newborn has characteristic findings different from the adult. This tracer also might have a prognostic value of clinical improvement following HIE. (author).

Analysis and assessment for the intrapulmonary kinetics of N-isopropyl-I-123-p-iodoamphetamine (IMP) in diffuse respiratory diseases

International Nuclear Information System (INIS)

Fujishima, Seitaro

1992-01-01

We investigated intrapulmonary kinetics of N-isopropyl-I-123-p-iodoamphetamine (IMP) in patients with diffuse respiratory diseases. Subjects studied were 4 healthy nonsmoking controls (age≥40), 3 young healthy nonsmokers (age 1 ) was smaller than that to the slow compartment (A 2 ). There was no difference in the A 1 to A 2 ratio among the groups. We then analyzed the slopes of the fast and slow compartments (k 1 , k 2 ). There was no difference in k 1 among the groups. On the other hand, k 2 was larger in young healthy nonsmokers and smaller in healthy smokers, the patients with IPF, sarcoidosis and CPE than k 2 in nonsmoking controls. Furthermore, k 2 decreased in inverse proportion to age. We concluded that k 2 could be a valuable index to detect changes of IMP, a lipophilic amine, metabolism in the lungs. (author)

The study of the lung accumulation of I-123 IMP by the broncho-alveolar lavage

International Nuclear Information System (INIS)

Itasaka, Miyoko; Ikeda, Hideki; Yakuwa, Naoshi; Kato, Shuichi; Takahashi, Keiji; Yasui, Shoji

1989-01-01

We studied the accumulated portion and the movement of I-123 IMP in the lung. Ten subjects were studied. They were four patients with fibrosing lung disease, two with lung cancer, and four with other lung disease. They underwent the broncho-alveolar lavage (BAL) for the diagnosis of their diseases. l.5 mCi of I-123 IMP was injected into the ante-cubital vein. The BAL examination was carried out about 40 minutes after the injection of I-123 IMP. The subjects' blood was sampled at the same time. The total BAL liquid (BAL-T) was divided into the fluid component (BAL-F) and the cell component (BAL-C) by centrifugation. The radioactivities in BAL-T, BAL-F, BAL-C, and serum (B-S) were measured by the well-counter. The average of BAL-T/B-S, BAL-F/B-S and BAL-C/B-S were 6.86, 4.26 and 2.71 respectively. It was confirmed that I-123 IMP was transported from the pulmonary capillary to the alveolar space and was taken up by the alveolar cells. It was considered that the analysis of the I-123 IMP release from the lung showed not only the endothelial cell uptake function but also the interstitial and material cells' amine transport and uptake function. (author)

Regional cerebral blood flow in epileptic foci using [I-123] IMP-SPECT

International Nuclear Information System (INIS)

Konishi, Tohru

1989-01-01

Fifty-six epileptic patients, whose ages ranged from 6 months to 16 years (a mean age, 8 years and 2 months), were examined by single photon emission computed tomography (SPECT) with [I-123] N-isopropyl p-iodoamphetamine (IMP). Of these patients, 44 had partial seizures (PS) and 12 had generalized seizures (GS). SPECT revealed abnormality of regional cerebral blood flow (rCBF) in 24 PS patients (54.5%), being correlated with EEG abnormality. Among the 24 patients, 22 had a decreased rCBF and 2 others had an increased rCBF. According to the PS type, rCBF abnormality in the foci was less frequently observed for benign age-related partial epilepsy (2/9) than for the other types of partial epilepsy (22/35). Among 35 patients with the other types of partial epilepsy, SPECT showed foci in the frontal (12), central (3), parietal (4), temporal (6), and occipital (6) regions, and diffuse spike-wave or the lack of paroaxysmals (4). The EEG foci was of the left hemisphere in 12 patients, and of the right hemisphere in 18 patients. Higher incidence of rCBF abnormality was associated with the temporal, partietal, and frontal foci than with the occipital foci. There was no correlation between the incidence of rCBF abnormlaity and the frequency of seizure activities on EEG. Complex partial seizures had a tendency to be associated with rCBF abnormality. In comparing IMP uptake in evaluable 17 patients with a decreased rCBF, a mean %CBF in foci compared to that in the contralateral area was 91.9%. All of the 12 GS patients showed no focal reduction of rCBF around the cortex. Patients with tonic-clonic seizure and myoclonic seizure had almost normal IMP images. The IMP images of organic lesions were a marked reduction of rCBF. IMP-SPECT may also be suitable for evaluating the underlying organic and secondary involving disorders with epilepsy. (N.K.)

Imp2, the PSTPIP homolog in fission yeast, affects sensitivity to the immunosuppressant FK506 and membrane trafficking in fission yeast

International Nuclear Information System (INIS)

Kita, Ayako; Higa, Mari; Doi, Akira; Satoh, Ryosuke; Sugiura, Reiko

2015-01-01

Cytokinesis is a highly ordered process that divides one cell into two cells, which is functionally linked to the dynamic remodeling of the plasma membrane coordinately with various events such as membrane trafficking. Calcineurin is a highly conserved serine/threonine protein phosphatase, which regulates multiple biological functions, such as membrane trafficking and cytokinesis. Here, we isolated imp2-c3, a mutant allele of the imp2 + gene, encoding a homolog of the mouse PSTPIP1 (proline-serine-threonine phosphatase interacting protein 1), using a genetic screen for mutations that are synthetically lethal with calcineurin deletion in fission yeast. The imp2-c3 mutants showed a defect in cytokinesis with multi-septated phenotypes, which was further enhanced upon treatment with the calcineurin inhibitor FK506. Notably, electron micrographs revealed that the imp2-c3 mutant cells accumulated aberrant multi-lamella Golgi structures and putative post-Golgi secretory vesicles, and exhibited fragmented vacuoles in addition to thickened septa. Consistently, imp2-c3 mutants showed a reduced secretion of acid phosphatase and defects in vacuole fusion. The imp2-c3 mutant cells exhibited a weakened cell wall, similar to the membrane trafficking mutants identified in the same genetic screen such as ypt3-i5. These findings implicate the PSTPIP1 homolog Imp2 in Golgi/vacuole function, thereby affecting various cellular processes, including cytokinesis and cell integrity. - Highlights: • We isolated imp2-c3, in a synthetic lethal screen with calcineurin in fission yeast. • The imp2 + gene encodes a component of the actin contractile ring similar to Cdc15. • The imp2-c3 mutants showed defects in cytokinesis, which were exacerbated by FK506. • The imp2-c3 mutants were defective in membrane trafficking and cell wall integrity. • Our study revealed a novel role for Imp2 in the Golgi/vacuolar membrane trafficking

Imp2, the PSTPIP homolog in fission yeast, affects sensitivity to the immunosuppressant FK506 and membrane trafficking in fission yeast

Energy Technology Data Exchange (ETDEWEB)

Kita, Ayako; Higa, Mari [Laboratory of Molecular Pharmacogenomics, School of Pharmaceutical Sciences, Kinki University, 3-4-1 Kowakae, Higashi-Osaka 577-8502 (Japan); Doi, Akira [Laboratory of Molecular Pharmacogenomics, School of Pharmaceutical Sciences, Kinki University, 3-4-1 Kowakae, Higashi-Osaka 577-8502 (Japan); Japan Society for the Promotion of Science, 1-8 Chiyoda-ku, Tokyo 102-8472 (Japan); Satoh, Ryosuke [Laboratory of Molecular Pharmacogenomics, School of Pharmaceutical Sciences, Kinki University, 3-4-1 Kowakae, Higashi-Osaka 577-8502 (Japan); Sugiura, Reiko, E-mail: sugiurar@phar.kindai.ac.jp [Laboratory of Molecular Pharmacogenomics, School of Pharmaceutical Sciences, Kinki University, 3-4-1 Kowakae, Higashi-Osaka 577-8502 (Japan)

2015-02-13

Cytokinesis is a highly ordered process that divides one cell into two cells, which is functionally linked to the dynamic remodeling of the plasma membrane coordinately with various events such as membrane trafficking. Calcineurin is a highly conserved serine/threonine protein phosphatase, which regulates multiple biological functions, such as membrane trafficking and cytokinesis. Here, we isolated imp2-c3, a mutant allele of the imp2{sup +} gene, encoding a homolog of the mouse PSTPIP1 (proline-serine-threonine phosphatase interacting protein 1), using a genetic screen for mutations that are synthetically lethal with calcineurin deletion in fission yeast. The imp2-c3 mutants showed a defect in cytokinesis with multi-septated phenotypes, which was further enhanced upon treatment with the calcineurin inhibitor FK506. Notably, electron micrographs revealed that the imp2-c3 mutant cells accumulated aberrant multi-lamella Golgi structures and putative post-Golgi secretory vesicles, and exhibited fragmented vacuoles in addition to thickened septa. Consistently, imp2-c3 mutants showed a reduced secretion of acid phosphatase and defects in vacuole fusion. The imp2-c3 mutant cells exhibited a weakened cell wall, similar to the membrane trafficking mutants identified in the same genetic screen such as ypt3-i5. These findings implicate the PSTPIP1 homolog Imp2 in Golgi/vacuole function, thereby affecting various cellular processes, including cytokinesis and cell integrity. - Highlights: • We isolated imp2-c3, in a synthetic lethal screen with calcineurin in fission yeast. • The imp2{sup +} gene encodes a component of the actin contractile ring similar to Cdc15. • The imp2-c3 mutants showed defects in cytokinesis, which were exacerbated by FK506. • The imp2-c3 mutants were defective in membrane trafficking and cell wall integrity. • Our study revealed a novel role for Imp2 in the Golgi/vacuolar membrane trafficking.

First-line chemoimmunotherapy in metastatic breast carcinoma: combination of paclitaxel and IMP321 (LAG-3Ig enhances immune responses and antitumor activity

Directory of Open Access Journals (Sweden)

Gligorov Joseph

2010-07-01

Full Text Available Abstract Background IMP321 is a recombinant soluble LAG-3Ig fusion protein that binds to MHC class II with high avidity and mediates APC and then antigen-experienced memory CD8+ T cell activation. We report clinical and biological results of a phase I/II in patients with metastatic breast carcinoma (MBC receiving first-line paclitaxel weekly, 3 weeks out of 4. Methods MBC patients were administered one dose of IMP321 s.c. every two weeks for a total of 24 weeks (12 injections. The repeated single doses were administered the day after chemotherapy at D2 and D16 of the 28-day cycles of paclitaxel (80 mg/m2 at D1, D8 and D15, for 6 cycles. Blood samples were taken 13 days after the sixth and the twelfth IMP321 injections to determine sustained APC, NK and memory CD8 T cell responses. Results Thirty MBC patients received IMP321 in three cohorts (doses: 0.25, 1.25 and 6.25 mg. IMP321 induced both a sustained increase in the number and activation of APC (monocytes and dendritic cells and an increase in the percentage of NK and long-lived cytotoxic effector-memory CD8 T cells. Clinical benefit was observed for 90% of patients with only 3 progressors at 6 months. Also, the objective tumor response rate of 50% compared favorably to the 25% rate reported in the historical control group. Conclusions The absence of toxicity and the demonstration of activity strongly support the future development of this agent for clinical use in combined first-line regimens. Trial registration ClinicalTrials.gov NCT00349934

Emergence of Imipenem-Resistant Pseudomonas aeruginosa Clinical Isolates from Egypt Coharboring VIM and IMP Carbapenemases.

Science.gov (United States)

El-Domany, Ramadan Ahmed; Emara, Mohamed; El-Magd, Mohammed A; Moustafa, Walaa H; Abdeltwab, Nesma M

2017-09-01

Pseudomonas aeruginosa is an important human pathogen and the leading cause of nosocomial infections. P. aeruginosa is characterized by massive intrinsic resistance to a multiple classes of antibiotics with carbapenems being the most potent inhibitor of P. aeruginosa and considered the first choice for its treatment. Therefore, it is crucial to investigate novel mechanisms of resistance of P. aeruginosa to carbapenems for achieving successful therapy. A total of 114 P. aeruginosa isolates from two university hospitals in Egypt were recruited in this study. Antimicrobial susceptibility testing revealed that 50 isolates (43.8%) exhibited multidrug-resistant (MDR) phenotype, of them 14 isolates (12.2%) were imipenem (IPM)-resistant. Of these 14 isolates, 13 isolates (11.4%) exhibited the metallo-β-lactamase (MBL) phenotype. MBLs encoding genes, VIM and IMP, were identified by PCR. PCR results revealed that four isolates harbored the VIM gene alone, one isolate harbored IMP gene alone, and four isolates harbored both genes. The correct size of PCR products of VIM and IMP genes (390 and 188 bp, respectively) were sequenced to confirm results of PCR and to look for any possible polymorphism among MBL genes of tested isolates. Data analysis of these sequences showed 100% identity of nucleotide sequences of MBL genes among tested Egyptian patients. To our knowledge, this is the first report of IMP carbapenemase-encoding gene in Africa and the first detection of the emergence of P. aeruginosa coproducing VIM and IMP genes in Egypt.

Earth Sciences Department Annual Report, 1984

Energy Technology Data Exchange (ETDEWEB)

Henry, A.L.; Donohue, M.L. (eds.)

1985-09-01

The Earth Sciences Department at Lawrence Livermore National Laboratory comprises nine different disciplinary and programmatic groups that provide research in the geosciences, including nuclear waste management, containment of nuclear weapons tests, seismic treaty verification, stimulation of natural gas production by unconventional means, and oil shale retorting. Each group's accomplishments in 1984 are discussed, followed by a listing of the group's publications for the year.

Structure of Cryptosporidium IMP dehydrogenase bound to an inhibitor with in vivo antiparasitic activity

Energy Technology Data Exchange (ETDEWEB)

Kim, Youngchang; Makowska-Grzyska, Magdalena; Gorla, Suresh Kumar; Gollapalli, Deviprasad R.; Cuny, Gregory D.; Joachimiak, Andrzej; Hedstrom, Lizbeth

2015-04-21

Inosine 5'-monophosphate dehydrogenase (IMPDH) is a promising target for the treatment ofCryptosporidiuminfections. Here, the structure ofC. parvumIMPDH (CpIMPDH) in complex with inosine 5'-monophosphate (IMP) and P131, an inhibitor within vivoanticryptosporidial activity, is reported. P131 contains two aromatic groups, one of which interacts with the hypoxanthine ring of IMP, while the second interacts with the aromatic ring of a tyrosine in the adjacent subunit. In addition, the amine and NO₂moieties bind in hydrated cavities, forming water-mediated hydrogen bonds to the protein. The design of compounds to replace these water molecules is a new strategy for the further optimization ofC. parvuminhibitors for both antiparasitic and antibacterial applications.

Characteristics of the magnetospheric boundary layer and magnetopause layer as observed by Imp 6

International Nuclear Information System (INIS)

Eastman, T.E.; Hones, E.W. Jr.

1979-01-01

Imp 6 observations of the low-latitude magnetospheric boundary layer indicate that the plasma within it is supplied primarily by direct entry of magnetosheath plasma across the magnetopause layer. We define the magnetopause layer as the current layer (separating the magnetosheath from the boundary layer) through which the magnetic field shifts in direction. High temporal resolution (3-s average) data reveal that in a majority of Imp 6 magnetopause crossing, no distinct changes in electron density or energry spectra are observed at the magne opause layer. In all Imp 6 crossings, some magnetosheathlike plasma is observed earthward of the magnetopause layer, implying the existence of a boundary layer. Boundary layer electron energy spectra are often virtually indistinguishable from the adjacent magnetosheath spectra. Low-latitude boundary layer bulk plasma flow as observed by Imp 6 almost always has an antisunward component and often has a significant cross-field component. The boundary layer thickness is highly variable and is generally much larger than the magnetopause layer thickness. Energetic electron pitch angle distributions indicate that the low-latitude boundary layers is normally on closed field lines. We conclude that diffusive as well as nondiffusive processes probably contribute to the entry of magnetosheath plasma into the boundary layer

123I-IMP SPECT study on patients with amnestic syndrome

International Nuclear Information System (INIS)

Hanyu, Haruo; Abe, Shinei; Arai, Hisayuki; Takasaki, Masaru; Suzuki, Takanari; Abe, Kimihiko; Amino, Saburo

1992-01-01

Regional cerebral blood flow was studied using single photon emission CT (SPECT) with 123 I-IMP to elucidate the pathophysiology of amnesia. Four patients with amnestic syndrome diagnosed by DSM-III-R criteria were investigated. SPECT images demonstrated definite hypoperfusion of the temporoparietal lobe and relative sparing of motorsensory and occipital cortices in two out of four patients. Since these abnormalities of regional cerebral blood flow have been considered to be characteristic findings in dementia of the Alzheimer type, two patients with temporoparietal hypoperfusion are suggested to manifest the early stage of dementia of the Alzheimer type. Our observations suggest that 123 I-IMP SPECT is an useful madality in the diagnosis of the early stage of dementia of the Alzheimer type, especially in patients with only memory impairment. (author)

Investigation of normal pressure hydrocephalus by sup 123 I-IMP SPECT

Energy Technology Data Exchange (ETDEWEB)

Kamiya, Ken; Yamashita, Nobuko; Nagai, Hajime [Nagoya City Univ. (Japan). Faculty of Medicine; Mizawa, Ikuo

1991-08-01

We evaluated N-isopropyl-p-({sup 123}I) iodoamphetamine ({sup 123}I-IMP) single photon emission computed tomography (SPECT) as a method for identifying normal pressure hydrocephalic (NPH) patients eligible for shunting procedures. {sup 123}I-IMP SPECT scans were taken before and after cerebrospinal fluid (CSF) taps in NPH cases. Post-subarachnoid hemorrhagic (SAH) patients showed apparent frontal blood flow reduction but non-SAH cases did not. The frontal blood flow increased in comparison with the temporal flow after CSF tapping in SAH cases who benefited most from shunting. Cerebral blood flow study before and after CSF removal is a potential method for classifying NPH patients likely to benefit from the shunting operation. (author).

IMP 2.0: a multi-species functional genomics portal for integration, visualization and prediction of protein functions and networks.

Science.gov (United States)

Wong, Aaron K; Krishnan, Arjun; Yao, Victoria; Tadych, Alicja; Troyanskaya, Olga G

2015-07-01

IMP (Integrative Multi-species Prediction), originally released in 2012, is an interactive web server that enables molecular biologists to interpret experimental results and to generate hypotheses in the context of a large cross-organism compendium of functional predictions and networks. The system provides biologists with a framework to analyze their candidate gene sets in the context of functional networks, expanding or refining their sets using functional relationships predicted from integrated high-throughput data. IMP 2.0 integrates updated prior knowledge and data collections from the last three years in the seven supported organisms (Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Danio rerio, Caenorhabditis elegans, and Saccharomyces cerevisiae) and extends function prediction coverage to include human disease. IMP identifies homologs with conserved functional roles for disease knowledge transfer, allowing biologists to analyze disease contexts and predictions across all organisms. Additionally, IMP 2.0 implements a new flexible platform for experts to generate custom hypotheses about biological processes or diseases, making sophisticated data-driven methods easily accessible to researchers. IMP does not require any registration or installation and is freely available for use at http://imp.princeton.edu. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

IMP metabolism in human skeletal muscle after exhaustive exercise

DEFF Research Database (Denmark)

Tullson, P. C.; Bangsbo, Jens; Hellsten, Ylva

1995-01-01

This study addressed whether AMP deaminase (AMPD)myosin binding occurs with deamination during intense exercise in humans and the extent of purine loss from muscle during the initial minutes of recovery. Male subjects performed cycle exercise (265 +/- 2 W for 4.39 +/- 0.04 min) to stimulate muscle...... inosine 5'-monophosphate (IMP) formation. After exercise, blood flow to one leg was occluded. Muscle biopsies (vastus lateralis) were taken before and 3.6 +/- 0.2 min after exercise from the occluded leg and 0.7 +/- 0.0, 1.1 +/- 0.0, and 2.9 +/- 0.1 min postexercise in the nonoccluded leg. Exercise...... activated AMPD; at exhaustion IMP was 3.5 +/- 0.4 mmol/kg dry muscle. Before exercise, 16.0 +/- 1.6% of AMPD cosedimented with the myosin fraction; the extent of AMPD:myosin binding was unchanged by exercise. Inosine content increased about threefold during exercise and twofold more during recovery; by 2...

Activity report of the Neutrino Research Group. Year 2006

International Nuclear Information System (INIS)

2007-01-01

For the last two decades, neutrino physics has been producing major discoveries including neutrino oscillations. These results gave clear confirmation that active neutrinos oscillate and therefore have mass with three different mass states. This is a very important result showing that the Minimal Standard Model is incomplete and requires an extension which is not yet known. The neutrino research field is very broad and active, at the frontier of today's particle physics. The Neutrino Research Group (GDR) was created in January 2005 with the aim of gathering CEA and CNRS research teams working on Neutrino Physics on experimental or theoretical level. This document is the 2006 activity report of the research group, two years after its creation. It presents the results of the 5 working groups: 1 - Determination of neutrino parameters; 2 - Physics beyond the standard model; 3 - Neutrinos in the universe; 4 - Accelerators, detection means, R and D and valorisation; 5 - Common tools to all working groups. The proposed neutrino physics road-map and the actual and future short-, medium- and long-term projects are presented in appendixes. The Neutrino research group organization, the Memphys specific mission group, the research group participating laboratories and teams, as well as the Memphys project are presented too

Highlights of the Winter 1984 Meeting. Business-Higher Education Forum (Scottsdale, Arizona, January 26-28, 1984).

Science.gov (United States)

Business-Higher Education Forum, Washington, DC.

Discussions of the Business-Higher Education Forum winter 1984 meeting are summarized. The Forum is a select group of about 80 chief executive officers from the largest corporations and higher education institutions in the United States. Welcoming remarks delivered by Arizona Governor Bruce E. Babbitt briefly address Arizona's future in…

Cerebral blood flow imaging by I-123 IMP and Tc-99m HM-PAO

Energy Technology Data Exchange (ETDEWEB)

Uno, Koichi; Yoshikawa, Kyosan; Minoshima, Satoshi; Imaseki, Keiko; Arimizu, Noboru; Yamaura, Akira; Uematsu, Sadao

1988-02-01

SPECT studies with either N-isopropyl-p-(I-123)iodo- amphetamine (I-123 IMP) or Tc-99m hexamethyl propylene amine oxime (Tc-99m HM-PAO) were cuncurrently performed in 12 patients with brain disorders, comprising cerebral infarction (7), cerebral aneurysm (one), intracranial hemorrhage (3), and subdural hematoma (one). Whereas I-123 IMP was taken up gradually into the brain, the uptake of Tc-99m-HM-PAO in the brain reached the peak immediately after the iv injection, with 90% or more remaining constant by 15 min postinjection. On early SPECT images, a high uptake of I-123 IMP was observed in the lung, and the uptake of Tc-99m HM-PAO was observed as well in the soft tissue of cervical region. In all patients except for one, decreased rCBF was observed in the lesions on both I-123 and Tc-99m SPECT scans. Both of the radiopharmaceuticals were analogous in that decreased blood flow corresponded to cerebral lesions. (Namekawa, K).

Diagnosis of Joseph disease by means of N-isopropyl-p-[123I]iodoamphetamine (IMP) SPECT

International Nuclear Information System (INIS)

Takahashi, Naoya; Nishihara, Mamiko; Odano, Ikuo; Sakai, Kunio; Yuasa, Tatsuhiko.

1993-01-01

Using N-isopropyl-p-[ 123 I]iodoamphetamine (IMP) and single-photon-emission computed tomography (SPECT), we studied the regional cerebral blood flow (rCBF) in 4 Japanese patients who had been clinically diagnosed as having Joseph disease. This is the first report of rCBF measurement by means of [ 123 I]-IMP SPECT in patients with Joseph disease. Cerebellar atrophy was evaluated by means of a 5-rating scale as defined by X-ray computed tomography (X-CT). As compared with 10 normal controls (mean cerebellar CBF±SD: 66.9±6.6 ml/100 g/min), the regional CBF of the patients with Joseph disease was found to decrease significantly in the cerebellum (mean±SD: 52.8±5.3 ml/100 g/min). However, no significant relationship was found between the decrease in rCBF in the cerebellum and the degree of cerebellar atrophy as shown by X-CT. The regional CBF in the cerebellum decreased little in one patient who had severe cerebellar atrophy or in two who showed moderate atrophy. [ 123 I]-IMP SPECT demonstrates the pathological and metabolic changes in the cerebellum that do not appear on X-CT or MRI. IMP SPECT is thus shown to be useful for the diagnosis of patients with Joseph disease. (author)

Tácito e o Império Romano

Directory of Open Access Journals (Sweden)

Fábio Duarte Joly

2010-06-01

Full Text Available A fortuna de Cornélio Tácito no pensamento político europeu demonstra a intensidade da recepção de sua obra nos debates sobre a natureza do poder monárquico e estratégias aristocráticas de ação na corte imperial. Neste sentido, do século XVI, Tácito foi muitas vezes tomado como um contemporâneo, num diálogo entre presente e passado, de acordo como uma noção de história entendida como magistra vitae. A bibliografia moderna sobre Tácito, de certa forma, ainda se mantém nesta trilha ao enfatizar, como objeto de estudo, primordialmente as representações taciteanas dos imperadores, de Augusto a Nero. Pretende-se, nesta comunicação, ampliar o foco de discussão, indagando-se sobre o próprio conceito de império na obra de Tácito, visando os apontar os elementos sublinhados pelo historiados latino como responsáveis pela manutenção do império de Roma, a despeito dos conflitos sociopolíticos internos.

Solar wind plasma periodicities observed at 1 AU by IMP 8

Science.gov (United States)

Paularena, K. I.; Szabo, A.; Lazarus, A. J.

1995-01-01

The IMP 8 spacecraft has been in Earth orbit since 1973, gathering plasma data over one complete 22-year solar cycle. These data are being examined to look for periodicities at time scales ranging from several hours to the entire span of the data set. A 1.3-year periodicity in the radial speed observed by IMP 8 and Voyager 2 has already been reported for the years from 1987 to 1993. The periodogram method, useful for unevenly sampled data such as the IMP 8 plasma data, has been used to search for other periods. It is interesting to note that the 13-year period is not present in the out-of-the-ecliptic component of the velocity (Vz), although a 1-year period is very obvious both visually and on the periodogram. Both components show a very strong peak associated with the 11-year solar cycle variation. This work will be extended to the thermal speed (a measure of the wind's temperature) and density, although the frequent correlations between these parameters and the velocity are expected to cause similar results. Additionally, the fine resolution data will be examined for shorter time periods than are visible using the hourly average data which are appropriate for longer periods. A comparison with periods observed at other spacecraft may also be made.

sup 123 I-IMP SPECT study on patients with amnestic syndrome

Energy Technology Data Exchange (ETDEWEB)

Hanyu, Haruo; Abe, Shinei; Arai, Hisayuki; Takasaki, Masaru; Suzuki, Takanari; Abe, Kimihiko; Amino, Saburo [Tokyo Medical Coll. (Japan)

1992-06-01

Regional cerebral blood flow was studied using single photon emission CT (SPECT) with {sup 123}I-IMP to elucidate the pathophysiology of amnesia. Four patients with amnestic syndrome diagnosed by DSM-III-R criteria were investigated. SPECT images demonstrated definite hypoperfusion of the temporoparietal lobe and relative sparing of motorsensory and occipital cortices in two out of four patients. Since these abnormalities of regional cerebral blood flow have been considered to be characteristic findings in dementia of the Alzheimer type, two patients with temporoparietal hypoperfusion are suggested to manifest the early stage of dementia of the Alzheimer type. Our observations suggest that {sup 123}I-IMP SPECT is an useful madality in the diagnosis of the early stage of dementia of the Alzheimer type, especially in patients with only memory impairment. (author).

N-isopropyl-4-[123I]iodoamphetamine (123I-IMP) products. A difference in radiochemical purity, unmetabolized fraction, and octanol extraction fraction in arterial blood and regional brain uptake in rats

International Nuclear Information System (INIS)

Kanai, Yasukazu; Hasegawa, Shinji; Kimura, Yasuyuki; Oku, Naohiko; Hatazawa, Jun; Ito, Hiroshi; Fukuda, Hiroshi

2007-01-01

N-isopropyl-4-[ 123 I]iodoamphetamine ( 123 I-IMP) is a lipophilic compound utilized for cerebral blood flow (CBF) measurement with single photon emission computed tomography (SPECT). Two different 123 I-IMP products (IMP A and IMP B ) are commercially available. We examined the radiochemical purity, unmetabolized fraction, and octanol extraction fraction in arterial blood, and the regional brain uptake of IMP A and IMP B in a rat model. IMP B (96.4%±0.08%, P A (95.5%±0.20%). The mean unmetabolized fraction in arterial blood taken at 10 min after intravenous administration of IMP B (69.5%±4.4%, P A (59.6%±2.6%). The mean octanol extraction fraction of IMP B (75.0%±1.3%, P A (67.2%±0.8%). The mean levels of radioactivity in arterial blood sampled at 10 min after injection and mean regional brain radioactivity (cerebral cortices, basal ganglia, brain stem, and cerebellum) at 10-12 min after injection were not significantly different between IMP A and IMP B . The present study indicates differences in the radiochemical purity and the unmetabolized and octanol extraction fraction in arterial blood between the two commercially available 123 I-IMP products. The appropriate octanol extraction fractions for IMP A and IMP B should be determined in humans and employed for quantitative CBF measurement in clinical SPECT. (author)

Differentiating Primary CNS Lymphoma from Malignant Glioma using 123I-IMP SPECT and Arterial Spin labeling

International Nuclear Information System (INIS)

Ito, Tamio; Sato, Kenichi; Ozaki, Yoshimaru; Asanome, Taku; Nakamura, Hirohiko; Ono, Hidetoshi

2016-01-01

Using conventional CT or MRI methods, the differentiation of primary central nervous system lymphoma (PCNSL) and malignant glioma (MG) is difficult because of overlapping imaging characteristics. Pretreatment differentiation between PCNSL and MG is essential for therapeutic decision making because post operative adjuvant therapy is extremely different. We examined the utility of N-isopropyl-p-[ 123 I]iodoamphetamine SPECT (IMP SPECT) and arterial spin labeling (ASL) in differentiating PCNSL from MG. Twenty PCNSL and ten MG patients underwent IMP SPECT and ASL. Early SPECT image (E) was initiated 20 min after intravenous injection of 222 MBq 123 I-IMP, and delayed image (D) and ultrade-layed image (UD) were initiated 3 h and 24 h, respectively, after the injection. SPECT images were visually analyzed with a color-grading scale (low, iso, and high), and the tumor-to-normal activity ratio (T/N) was calculated for all three images. The pulsed ASL was performed using a 3-T system. We set regions of interest in the tumor and symmetrically in the contralateral white matter on the cerebral blood flow (CBF) map and estimated tumor blood flow (TBF)/CBF ratio (TBF/CBF). 1) IMP SPECT: (1) Visual image analysis of PCNSL cases showed high accumulation of 123 I-IMP up-take on D and UD, whereas most MG cases showed low accumulation. (2) T/Ns of PCNSL were significantly higher than those of MG on D and UD (E: 1.13 vs. 0.95, p>0.05; D: 1.23 vs. 0.86, p<0.01; UD: 1.40 vs. 0.86, p<0.01). 2) ASL: TBF/CBFs of MG were higher than those of PCNSL, particularly in glioblastoma patients [1.84 vs. 6.22 (III; 1.51, IV; 8.58)]. IMP SPECT and ASL are helpful tools for differentiating primary CNS lymphoma from MG. Using these examinations, we could perform adjuvant therapy without biopsy in deep-seated tumors. (author)

Optimization of labeling conditions of n-isopropyl-p-iodoamphetamine chloridate (IMP) with radioiodine. Biological distribution studies

International Nuclear Information System (INIS)

Colturato, Maria Tereza

2000-01-01

The development of this work was based on a great interest from the medical community in the utilization of N-isopropyl-p-iodoamphetamine chloridate (IMP) labeled with 123 l, for brain perfusion evaluation. The IMP was initially characterized by: Melting Point (MP), Infrared Spectrophotometry (IR), Nuclear Magnetic Resonance Spectrometry (NMR), Elemental Analysis and High Performance Liquid Chromatography (HPLC). After having chosen the ideal method (nucleophilic substitution) to label IMP with that used Cu(I) as reducing agent and ascorbic acid as catalyzing of Cu(II), studies were performed to optimize the labeling parameters of 123 l-IMP: temperature reaction, time reaction, ascorbic acid mass, pH and molar ratio, and stability of the final product. The quality control method (ascending paper chromatographic) used to determine the radiochemistry purity showed to be efficient, fast and of easily handling for routine production. Biological distribution studies were performed with laboratory animals (mice) to determine the percent administered dose in the blood, different organs and whole body after intravenous administration of the radiopharmaceutical. Toxicological evaluation and in vitro study to determine the plasmatic protein binding were also done. The data of the biological distribution in mice have shown that the product crossed the intact blood brain barrier, for a enough time to obtain brain scintigraphic image, thus, allowing a follow up of further studies after the intravenous administration of the radiopharmaceutical. The 123 l-IMP showed a blood clearance and then the principal elimination route was the urinary. The kinetic study of 123 l-IMP, submitting blood samples data to BIEXP.BAS program, showed a biexponential pattern which allowed demonstrating that the compound presents a first phase of quick distribution and a second one slower corresponding to the equilibrium and elimination. Based on the results from radiochemical purity, stability and

Improving AIDS Care After Trauma (ImpACT): Pilot Outcomes of a Coping intervention Among HIV-Infected Women with Sexual Trauma in South Africa.

Science.gov (United States)

Sikkema, Kathleen J; Mulawa, Marta I; Robertson, Corne; Watt, Melissa H; Ciya, Nonceba; Stein, Dan J; Cherenack, Emily M; Choi, Karmel W; Kombora, Matapelo; Joska, John A

2018-03-01

Improving AIDS Care after Trauma (ImpACT), a coping intervention for HIV-infected women with sexual abuse histories, was evaluated for feasibility and potential efficacy in a public clinic in Cape Town, South Africa. Sixty-four participants were enrolled prior to starting antiretroviral therapy (ART). After completing baseline assessments, participants were randomly assigned to standard of care (SoC: three adherence counseling sessions) or ImpACT (SoC plus four individual and three group sessions). Participants completed assessments at 3 months (after individual sessions) and 6 months post-baseline. In exploratory analysis of primary outcomes, ImpACT participants, compared to SoC, reported greater reductions in avoidance and arousal symptoms of PTSD and greater increases in ART adherence motivation at 3 months. Clinically significant decreases in overall PTSD symptoms were also demonstrated at 3 months. These effects continued as trends at the 6-month assessment, in addition to increases in social/spiritual coping. In analysis of secondary outcomes, high levels of non-adherence to ART and poor care engagement were evident at 6 months, with no differences between study arms. A trauma-focused, culturally-adapted individual intervention delivered by a non-specialist in the HIV care setting is feasible and acceptable. Preliminary findings suggest ImpACT has potential to reduce PTSD symptoms and increase ART adherence motivation, but a more intensive intervention may be needed to improve and maintain care engagement among this population. ClinicalTrials.gov NCT02223390.

Insulin-like growth factor II mRNA binding protein 3 (IMP3) is overexpressed in prostate cancer and correlates with higher Gleason scores

International Nuclear Information System (INIS)

Ikenberg, Kristian; Behnke, Silvia; Gerhardt, Josefine; Mortezavi, Ashkan; Wild, Peter; Hofstädter, Ferdinand; Burger, Maximilian; Moch, Holger; Kristiansen, Glen; Fritzsche, Florian R; Zuerrer-Haerdi, Ursina; Hofmann, Irina; Hermanns, Thomas; Seifert, Helge; Müntener, Michael; Provenzano, Maurizio; Sulser, Tullio

2010-01-01

The oncofetal protein insulin-like growth factor II mRNA binding protein 3 (IMP3) is an important factor for cell-migration and adhesion in malignancies. Recent studies have shown a remarkable overexpression of IMP3 in different human malignant neoplasms and also revealed it as an important prognostic marker in some tumor entities. To our knowledge, IMP3 expression has not been investigated in prostate carcinomas so far. Immunohistochemical stainings for IMP3 were performed on tissue microarray (TMA) organized samples from 507 patients: 31 normal prostate tissues, 425 primary carcinomas and 51 prostate cancer metastases or castration-resistant prostate cancers (CRPC). IMP3 immunoreactivity was semiquantitatively scored and correlated with clinical-pathologic parameters including survival. IMP3 is significantly stronger expressed in prostate carcinomas compared to normal prostate tissues (p < 0.0001), but did not show significant correlation with the pT-stage, the proliferation index (MIB1), preoperative serum PSA level and the margin status. Only a weak and slightly significant correlation was found with the Gleason score and IMP3 expression failed to show prognostic significance in clinico-pathological correlation-analyses. Although IMP3 is overexpressed in a significant proportion of prostate cancer cases, which might be of importance for novel therapeutic approaches, it does not appear to possess any immediate diagnostic or prognostic value, limiting its potential as a tissue biomarker for prostate cancer. These results might be corroborated by the fact, that two independent tumor cohorts were separately reviewed

Linguagem e ideologia do Império estadunidense

Directory of Open Access Journals (Sweden)

Antonio Ozaí da Silva

2010-07-01

Full Text Available

resenha: LOSURDO, Domenico. A linguagem do império: léxico da ideologia estadunidense. São Paulo: Boitempo, 2010, 303p.

Insulin-like growth factor II mRNA binding protein 3 (IMP3 is overexpressed in prostate cancer and correlates with higher Gleason scores

Directory of Open Access Journals (Sweden)

Mortezavi Ashkan

2010-06-01

Full Text Available Abstract Background The oncofetal protein insulin-like growth factor II mRNA binding protein 3 (IMP3 is an important factor for cell-migration and adhesion in malignancies. Recent studies have shown a remarkable overexpression of IMP3 in different human malignant neoplasms and also revealed it as an important prognostic marker in some tumor entities. To our knowledge, IMP3 expression has not been investigated in prostate carcinomas so far. Methods Immunohistochemical stainings for IMP3 were performed on tissue microarray (TMA organized samples from 507 patients: 31 normal prostate tissues, 425 primary carcinomas and 51 prostate cancer metastases or castration-resistant prostate cancers (CRPC. IMP3 immunoreactivity was semiquantitatively scored and correlated with clinical-pathologic parameters including survival. Results IMP3 is significantly stronger expressed in prostate carcinomas compared to normal prostate tissues (p Conclusions Although IMP3 is overexpressed in a significant proportion of prostate cancer cases, which might be of importance for novel therapeutic approaches, it does not appear to possess any immediate diagnostic or prognostic value, limiting its potential as a tissue biomarker for prostate cancer. These results might be corroborated by the fact, that two independent tumor cohorts were separately reviewed.

Characterization of the Eimeria maxima sporozoite surface protein IMP1

Science.gov (United States)

The purpose of this study was to characterize Eimeria maxima immunoprotective protein IMP1 that is hypothesized to play a role in eliciting protective immunity against E. maxima infection in chickens. RT-PCR analysis of RNA from unsporulated and sporulating E. maxima oocysts revealed highest transc...

Annual report 1984 Chemistry Department

International Nuclear Information System (INIS)

Funck, J.; Larsen, E.; Nielsen, O.J.

1985-03-01

This report contains a brief survey of the main activities in the Chemistry Department. All articles and reports published and lectures given in 1984 are presented. The facilities and equipment are mentioned briefly. The activities are divided into the following groups: radioisotope chemistry, analytical- and organic chemistry , environmental chemistry, polymer chemistry, geochemistry and waste disposal, radical chemistry, positron annihilation, mineral processing, and general. (author)

New American Home(R) 2006

Energy Technology Data Exchange (ETDEWEB)

2005-11-01

The New American Home(R) is a ''real-world'' laboratory demonstrating concepts, materials, designs, and construction techniques that can be replicated--in whole or in part--in housing built any place and in any price range. Since its inception in 1984, TNAH has the unique distinction of being both a show house and a for-sale product, balancing architectural freedom and the bottom line. It is a collection of ideas for the industry to take away and put into hundreds of thousands of homes across the country each year. TNAH 2006 was built with technical support from IBACOS and on-site support from IHP.

Analysis of the spatial distribution of infant mortality by cause of death in Austria in 1984 to 2006

Directory of Open Access Journals (Sweden)

Heinzl Harald

2008-05-01

Full Text Available Abstract Background In Austria, over the last 20 years infant mortality declined from 11.2 per 1,000 life births (1985 to 4.7 per 1,000 in1997 but remained rather constant since then. In addition to this time trend we already reported a non-random spatial distribution of infant mortality rates in a recent study covering the time period 1984 to 2002. This present study includes four additional years and now covers about 1.9 million individual birth certificates. It aimes to elucidate the observed non-random spatial distribution in more detail. We split up infant mortality into six groups according to the underlying cause of death. The underlying spatial distribution of standardized mortality ratios (SMR is estimated by univariate models as well as by two models incorporating all six groups simultaneously. Results We observe strong correlations between the individual spatial patterns of SMR's except for "Sudden Infant Death Syndrome" and to some extent for "Peripartal Problems". The spatial distribution of SMR's is non-random with an area of decreased risk in the South-East of Austria. The group "Sudden Infant Death Syndrome" clearly and the group "Peripartal Problems" slightly show deviations from the common pattern. When comparing univariate and multivariate SMR estimates we observe that the resulting spatial distributions are very similar. Conclusion We observe different non-random spatial distributions of infant mortality rates when grouped by cause of death. The models applied were based on individual data thereby avoiding ecological regression bias. The estimated spatial distributions do not substantially depend on the employed estimation method. The observed non-random spatial patterns of Austrian infant mortality remain to appear ambiguous.

Clinical utility of N-isopropyl-p-[123I] iodoamphetamine (123I-IMP) for SPECT in epileptic children

International Nuclear Information System (INIS)

Taki, Kuniyasu; Seto, Hikaru; Futatsuya, Ryusuke; Kakishita, Masao; Seki, Hiroyasu.

1989-01-01

A regional cerebral perfusion study was performed in epileptic children using single photon emission computed tomography (SPECT) and N-isopropyl-p-[ 123 I] iodoamphetamine ( 123 I-IMP). A total of 22 patients with epilepsy underwent both a 123 I-IMP brain perfusion study and X-ray CT. Eighteen had positive and four had negative perfusion study results. Of the eighteen patients with positive perfusion study results, two were positive on X-ray CT. In these two patients, the areas of perfusion defects were larger than those of low density on X-ray CT. In only four patients did the areas of perfusion defects correspond to the sites of abnormal EEG. In conclusion, 123 I-IMP perfusion study is of great clinical value in pediatric epileptic cases. (author)

3',5'-cIMP as Potential Second Messenger in the Vascular Wall.

Science.gov (United States)

Leung, Susan W S; Gao, Yuansheng; Vanhoutte, Paul M

2017-01-01

Traditionally, only the 3',5'-cyclic monophosphates of adenosine and guanosine (produced by adenylyl cyclase and guanylyl cyclase, respectively) are regarded as true "second messengers" in the vascular wall, despite the presence of other cyclic nucleotides in different tissues. Among these noncanonical cyclic nucleotides, inosine 3',5'-cyclic monophosphate (cIMP) is synthesized by soluble guanylyl cyclase in porcine coronary arteries in response to hypoxia, when the enzyme is activated by endothelium-derived nitric oxide. Its production is associated with augmentation of vascular contraction mediated by stimulation of Rho kinase. Based on these findings, cIMP appears to meet most, if not all, of the criteria required for it to be accepted as a "second messenger," at least in the vascular wall.

Portosystemic shunting in portal hypertension: evaluation with portal scintigraphy with transrectally administered I-123 IMP

International Nuclear Information System (INIS)

Kashiwagi, T.; Azuma, M.; Ikawa, T.; Takehara, T.; Matsuda, H.; Yoshioka, H.; Mitsutani, N.; Koizumi, T.; Kimura, K.

1988-01-01

Portosystemic shunting was evaluated with rectal administration of iodine-123 iodoamphetamine (IMP) in seven patients without liver disease and 53 patients with liver cirrhosis. IMP (2-3 mCi [74-111 MBq]) was administered to the rectum through a catheter. Images of the chest and abdomen were obtained for up to 60 minutes with a scintillation camera interfaced with a computer. In all patients, images of the liver and/or lungs were observed within 5-10 minutes and became clear with time. In patients without liver disease, only liver images could be obtained, whereas the lung was visualized with or without the liver in all patients with liver cirrhosis. The portosystemic shunt index was calculated by dividing counts of lungs by counts of liver and lung. These values were significantly higher in liver cirrhosis, especially in the decompensated stage. Transrectal portal scintigraphy with IMP appears to be a useful method for noninvasive and quantitative evaluation of portosystemic shunting in portal hypertension

IMP-SPECT at patients with hallucinations

International Nuclear Information System (INIS)

Podreka, I.; Mamoli, B.; Lesch, O.; Suess, E.; Wimberger, D.; Mayr, N.; Havelec, L.; Mueller, C.; Steiner, M.; Deecke, L.

1986-01-01

IMP-SPECT was performed in 14 normal volunteers. A 'regional index=RI' of tracer distribution was calculated for 18 regions in each hemisphere RI=(cts/voxel ROI)/(mean cts/voxel of all ROI's). 30 seizure patients (E) and 12 patients with acoustic, partialy also visual hallucinations (H) were investigated. Regions were defined as hypo- or hyperperfused if the RI exceeded the value of the corresponding normal-RI +- 2 std. EEG was recorded in all (E). 93.3% of EEG-findings were abnormal, 50% showed a focus, 46.7% paroxysmal activity. SPECT detected in 93.3% of (E) hypoperfused regions, mostly located in the temporal lobe. All (H) had decreased rCBF, predominantly in the frontal cortex. ANOVA and t-test revealed significant RI-differences in the frontal lobe, both hippocampi, right and left inferior occipital cortex, and right anterior basal ganglia. (H) had lower RI's in frontal lobes, higher RI's in both hippocampal regions as well as inferior occipital regions and anterior basal ganglia Differences between (E) and (H) were found in the frontal lobe ((H)sub(→)), right superior temporal region ((H)sup(→)), left hippocampus ((H)sup(→)), both inferior occipital regions ((H)sup(→)) and right anterior basal ganglia ((H)sup(→)). The study shows that by means of IMP-SPECT hypo- and hyperperfused areas can be detected in the hemispheres of (E) and (H), corresponding to disturbed brain function. Higher hippocampal CBF in (E) and (H) may be related to the role of this limbic structure in generation of seizures and psychotic states. Hallucinations are associated with increased CBF in the right temporal and associative visual cortex. (Author)

A new graphic method for evaluation of distribution volume on N-isopropyl-p-[123I]iodoamphetamine (IMP) SPECT

International Nuclear Information System (INIS)

Odano, Ikuo; Takahashi, Naoya; Ohtaki, Hiroh; Noguchi, Eikichi; Hatano, Masayoshi; Yamasaki, Yoshihiro; Nishihara, Mamiko; Ohkubo, Masaki; Yokoi, Takashi.

1993-01-01

We developed a new graphic method using N-isopropyl-p-[ 123 I]iodoamphetamine (IMP) and SPECT of the brain, the graph on which all three parameters, cerebral blood flow, distribution volume (V d ) and delayed count to early count ratio (Delayed/Early ratio), were able to be evaluated simultaneously. The kinetics of 123 I-IMP in the brain was analyzed by a 2-compartment model, and a standard input function was prepared by averaging the time activity curves of 123 I-IMP in arterial blood on 6 patients with small cerebral infarction etc. including 2 normal controls. Being applied this method to the differential diagnosis between Parkinson's disease and progressive supranuclear palsy, we were able to differentiate both with a glance, because the distribution volume of the frontal lobe significantly decreased in Parkinson's disease (Mean±SD; 26±6 ml/g). This method was clinically useful. We think that the distribution volume of 123 I-IMP may reflect its retention mechanism in the brain, and the values are related to amine, especially to dopamine receptors and its metabolism. (author)

123I-IMP single photon emission computed tomography (SPECT) study in childhood epilepsy

International Nuclear Information System (INIS)

Hara, Masafumi; Shimomura, Osamu; Kojima, Akihiro; Izunaga, Hiroshi; Tomiguchi, Seiji; Hirota, Yoshihisa; Taku, Keiichi; Miike, Teruhisa; Takahashi, Mutsumasa

1990-01-01

N-isopropyl-p[ 123 I]-iodoamphetamine (IMP) single photon emission computed tomography (SPECT), X-ray computed tomography (X-CT) and magnetic resonance imaging (MRI) were performed in 18 children with idiopathic seizures. In children with idiopathic seizures SPECT identified abnormal lesions in the highest rate (50%) compared with X-CT (11%) and MRI (13%), but the findings of SPECT poorly correlated with the foci on electroencephalography (EEG). Idiopathic epilepsy with abnormal uptake on SPECT was refractory to medical treatments and frequently associated with mental and/or developmental retardation. Perfusion defects identified on SPECT probably influenced the development of the brains in children. IMP SPECT is useful in the diagnosis and medical treatment in children with seizures. (author)

8. Seminar of the IMP-IIE-ININ on technological specialties. Topic 10: Earth Sciences; 8. Seminario IMP-IIE-ININ sobre especialidades tecnologicas. Mesa 10: Ciencias de la Tierra

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-12-31

The document contains two papers within INIS subject scope which were presented at the 8th Seminar of the IMP-IIE-ININ on technological specialties. Topic 10: Earth Sciences. A separate abstract was prepared for each paper.

The novel anthraquinone derivative IMP1338 induces death of human cancer cells by p53-independent S and G2/M cell cycle arrest.

Science.gov (United States)

Choi, Hyun Kyung; Ryu, Hwani; Son, A-Rang; Seo, Bitna; Hwang, Sang-Gu; Song, Jie-Young; Ahn, Jiyeon

2016-04-01

To identify novel small molecules that induce selective cancer cell death, we screened a chemical library containing 1040 compounds in HT29 colon cancer and CCD18-Co normal colon cells, using a phenotypic cell-based viability assay system with the Cell Counting Kit-8 (CCK-8). We discovered a novel anthraquinone derivative, N-(4-[{(9,10-dioxo-9,10-dihydro-1-anthracenyl)sulfonyl}amino]phenyl)-N-methylacetamide (IMP1338), which was cytotoxic against the human colon cancer cells tested. The MTT cell viability assay showed that treatment with IMP1338 selectively inhibited HCT116, HCT116 p53(-/-), HT29, and A549 cancer cell proliferation compared to that of Beas2B normal epithelial cells. To elucidate the cellular mechanism underlying the cytotoxicity of IMP1338, we examined the effect of IMP1338 on the cell cycle distribution and death of cancer cells. IMP1338 treatment significantly arrested the cell cycle at S and G2/M phases by DNA damage and led to apoptotic cell death, which was determined using FACS analysis with Annexin V/PI double staining. Furthermore, IMP1338 increased caspase-3 cleavage in wild-type p53, p53 knockout HCT116, and HT29 cells as determined using immunoblotting. In addition, IMP1338 markedly induced the phosphorylation of histone H2AX and Chk1 in both cell lines while the combination of 5-fluorouracil (5-FU) and radiation inhibited the viability of HCT116, HCT116 p53(-/-), and HT29 cells compared to 5-FU or radiation alone. Our findings indicated that IMP1338 induced p53-independent cell death through S and G2/M phase arrest as well as DNA damage. These results provide a basis for future investigations assessing the promising anticancer properties of IMP1338. Copyright © 2016. Published by Elsevier Masson SAS.

Pathophysiologic study of chronic infarcts with I-123 isopropyl iodo-amphetamine (IMP)

DEFF Research Database (Denmark)

Raynaud, C; Rancurel, G; Samson, Y

1987-01-01

Seventeen chronic cerebral infarcts were investigated by a highly sensitive, dedicated brain single photon emission computerized tomography system using 123I-isopropyl iodoamphetamine (IMP) and 133Xe. IMP uptake was measured 10 minutes, 2 hours, and 5 hours after injection, and regional cerebral...... blood flow was measured with 133Xe. In 4 cases a positron emission tomography system was used to measure the rCBF and the regional metabolic rate of oxygen with C15O2 and 15O2. The results obtained allowed us to identify 2 abnormal zones. One, the "central area," was characterized by a severe decrease...... ischemic neuronal loss. The results stress the important role played by the peripheral area, which may be useful in establishing the prognosis and evaluating the efficacy of therapy in individual stroke cases....

Incorporation of a recombinant Eimeria maxima IMP1 antigen into nanoparticles confers protective immunity against E. maxima challenge infection

Science.gov (United States)

The purpose of this study was to determine if incorporating a recombinant Eimeria maxima protein, namely rEmaxIMP1, into gold nanoparticles (NP) could improve the level of protective immunity against E. maxima challenge infection. Recombinant EmaxIMP1 was expressed in Escherchia coli as a poly-His f...

Detection of VIM-2-, IMP-1- and NDM-1-producing multidrug resistant Pseudomonas aeruginosa in Malaysia.

Science.gov (United States)

Liew, Siew Mun; Rajasekaram, Ganeswrei; Puthucheary, Savithri D; Chua, Kek Heng

2018-02-09

The increasing incidence of carbapenem-resistant Pseudomonas aeruginosa along with the discovery of novel metallo-β-lactamases (MBLs) is of concern. In this study, the isolation of Malaysian MBL-producing P. aeruginosa clinical strains was investigated. Fifty-three P. aeruginosa clinical strains were isolated from different patients in Sultanah Aminah Hospital, Johor Bahru, Malaysia in 2015. Antimicrobial susceptibility test was conducted. Minimum inhibitory concentrations (MICs) of imipenem and meropenem were determined by Etest. The carbapenem-resistant strains were screened for MBL production by IMP-EDTA double disk synergy test (DDST), MBL imipenem/imipenem-inhibitor (IP/IPI) Etest and polymerase chain reaction (PCR). Genotyping was performed by multilocus sequence typing (MLST) analysis. Three (5.7%) clinical strains were identified as MBL producers. Multidrug resistance was observed in the three strains, and two were resistant to all the antimicrobials tested. Sequencing analysis confirmed the three strains to harbour carbapenemase genes: one with bla IMP-1 , one with bla VIM-2 and the other with bla NDM-1 genes. These multidrug resistant strains were identified as sequence type (ST) 235 and ST308. None of the bla IMP-1 and bla NDM-1 genes have been reported in Malaysian P. aeruginosa. The emergence of imipenemase 1 (IMP-1)- and New Delhi metallo-β-lactamase 1 (NDM-1)-producing P. aeruginosa in Malaysia maybe travel-associated. Copyright © 2018. Published by Elsevier Ltd.

A study of crossed cerebellar diaschisis on 123I-IMP SPECT images and its redistribution phenomenon

International Nuclear Information System (INIS)

Odano, Ikuo; Takahashi, Naoya; Nishihara, Mamiko; Otaki, Hiro; Noguchi, Eikichi; Yamazaki, Yoshihiro; Kimura, Motomasa; Sakai, Kunio; Okubo, Masaki.

1993-01-01

Crossed cerebellar diaschisis (CCD) is interpreted as a functional deactivation, presumably caused by a loss of excitatory or inhibitory afferent inputs on the corticopontocerebellar pathway and others. A redistribution phenomenon (RD) is usually observed in the contralateral cerebellum with CCD on delayed images of 123 I-IMP SPECT. This phenomenon was analyzed in a view point of rCBF measurement in 24 patients with brain tumor, infarction and so forth. Regional CBF was measured by the microsphere method with 123 I-IMP and a delayed-to-early counts ratio (D/E ratio) was used. As a result, there was no relation between rCBF and the D/E ratio in the cerebellum, which means that RD is caused by other factors except for rCBF in the cerebellum. Regional CBF and the D/E ratio in the contralateral and ipsilateral cerebellum was 46.3 ml/100 g/min, 1.01 and 57.0 ml/100 g/min, 0.86, respectively. These results mean that the high activity of IMP gradually decreased in the ipsilateral cerebellum, while the low activity in the contralateral cerebellum was almost stable, and the difference of both activity reduced after 5 hours and RD was observed on the delayed image. The data indicate that retention mechanism of IMP and vascular permeability are not affected in the cerebellum with CCD. (author)

A study of cerebral circulation in elderly patients with dementia using sup 123 I-IMP SPECT

Energy Technology Data Exchange (ETDEWEB)

Arai, Hisayuki [Tokyo Medical Coll. (Japan)

1991-03-01

In order to elucidate the pathogenesis of senile dementia of Alzheimer type (SDAT) and multi-infarct dementia (MID), 18 age-matched controls, 22 SDAT cases, 10 MID cases, and 15 multiple infarction without dementia (MI) cases, totaling 65 cases, were enrolled into a study of cerebral blood flow using single photon emission CT (SPECT) with N-isopropyl-p-({sup 123}I)iodoamphetamine (IMP). The diagnosis of dementia was made based on the clinical history, findings of brain CT, MRI, and Hachinski's ischemic score. Lateral asymmetric perfusion was evaluated by using the asymmetry index (AI). Quantitative cerebral blood flow was analyzed by using the venous blood sampling method with IMP SPECT. Cerebral infarction, ischemic changes, and brain atrophy were diagnosed by CT and MRI. mCBF values were significantly lower in SDAT and MID than in those of controls, while rCBF values were lowest at the frontal lobes in MID and at the parietal lobes in SDAT. Hasegawa's dementia score was correlated with the rCBF at the frontal lobes in MID. In MID, there was a greater number of infarction, and atrophic changes were significantly remarkable, while the rCBF values were significantly lower at the frontal lobes compared to the MI group. Multi-variate analysis suggested that among the factors contributing to MID, brain atrophy was most relevant to dementia. In SDAT, rCBF values showed the most lateral asymmetry at the parietal lobes, the least, at the occipital lobes. The lateral asymmetry of the cerebral blood flow at the parietal lobes showed an association with clinical symptoms. There was a negative coefficiency between the cerebellum and the cerebral hemisphere in the evaluation of lateral asymmetry. These results suggest that rCBF estimation by IMP SPECT is useful in the differential diagnosis between MID and SDAT, and may also contribute to the classification of these two diseases. (author).

Effect of two non-synonymous ecto-5'-nucleotidase variants on the genetic architecture of inosine 5'-monophosphate (IMP) and its degradation products in Japanese Black beef.

Science.gov (United States)

Uemoto, Yoshinobu; Ohtake, Tsuyoshi; Sasago, Nanae; Takeda, Masayuki; Abe, Tsuyoshi; Sakuma, Hironori; Kojima, Takatoshi; Sasaki, Shinji

2017-11-13

Umami is a Japanese term for the fifth basic taste and is an important sensory property of beef palatability. Inosine 5'-monophosphate (IMP) contributes to umami taste in beef. Thus, the overall change in concentration of IMP and its degradation products can potentially affect the beef palatability. In this study, we investigated the genetic architecture of IMP and its degradation products in Japanese Black beef. First, we performed genome-wide association study (GWAS), candidate gene analysis, and functional analysis to detect the causal variants that affect IMP, inosine, and hypoxanthine. Second, we evaluated the allele frequencies in the different breeds, the contribution of genetic variance, and the effect on other economical traits using the detected variants. A total of 574 Japanese Black cattle were genotyped using the Illumina BovineSNP50 BeadChip and were then used for GWAS. The results of GWAS showed that the genome-wide significant single nucleotide polymorphisms (SNPs) on BTA9 were detected for IMP, inosine, and hypoxanthine. The ecto-5'-nucleotidase (NT5E) gene, which encodes the enzyme NT5E for the extracellular degradation of IMP to inosine, was located near the significant region on BTA9. The results of candidate gene analysis and functional analysis showed that two non-synonymous SNPs (c.1318C > T and c.1475 T > A) in NT5E affected the amount of IMP and its degradation products in beef by regulating the enzymatic activity of NT5E. The Q haplotype showed a positive effect on IMP and a negative effect on the enzymatic activity of NT5E in IMP degradation. The two SNPs were under perfect linkage disequilibrium in five different breeds, and different haplotype frequencies were seen among breeds. The two SNPs contribute to about half of the total genetic variance in IMP, and the results of genetic relationship between IMP and its degradation products showed that NT5E affected the overall concentration balance of IMP and its degradation products

1984. Annual progress report

International Nuclear Information System (INIS)

1985-01-01

This report presents the research works developed at the Nuclear Physics Institute of Lyon during the year 1984 in the following fields: theoretical physics, high-energy and intermediate-energy physics, nuclear physics, inter-disciplinary physics, instrumentation. A list of the publications of the year 1984 is finally given [fr

Clinical evaluation of Parkinson's disease using 123I-IMP SPECT

International Nuclear Information System (INIS)

Hayashi, Hiroko; Odano, Ikuo; Nishihara, Mamiko; Higuchi, Shouichi; Sakai, Kunio; Ishikawa, Atsushi.

1989-01-01

N-isopropyl-p[ 123 I]iodoamphetamine ( 123 I-IMP) SPECT and regional cerebral blood flow (rCBF) studies were performed in 20 patients with Parkinson's disease (PD) and 8 normal subjects. RCBF was measured by the arterial blood sampling method which used the microsphere model. We analized seven factors which might be related to the rCBF in PD, i.e., age, stage, duration of the disease, cerebral atrophy, severity of dementia, laterality of symptoms and motor disability score (MDS; the degree of akinesia, rigidity, tremor, gait disturbance, freezing and pulsion sign). Compared with normal subjects, global CBF (supratentorial mean rCBF) was reduced by 21.8% in PD. In particular, rCBF in the basal ganglia and that of frontal cortex were reduced by 25.3% and 24.8%, respectively. Distribution patterns of rCBF in PD were almost as same as those in normals except for cerebellum. The reduction of both rCBFs in the basal ganglia and parietal cortex significantly correlated with MDS (p 123 I-IMP SPECT study is a useful method for clinical evaluation of PD. (author)

7. Seminar of the IIE-ININ-IMP on technological specialties. Topic 10: Information Services; 7. Seminario IIE-ININ-IMP sobre especialidades tecnologicas. Mesa 10. Servicios de informacion.

Energy Technology Data Exchange (ETDEWEB)

NONE

1994-12-31

The document includes 10 papers presented at the 7. Seminar of the IIE-IMP-ININ (Mexico) on technological specialities in the field of information services (Topic 10). Three items were in INIS subject scope and a separate abstract was prepared for each of them.

A new graphic method for evaluation of distribution volume on N-isopropyl-p-[[sup 123]I]iodoamphetamine (IMP) SPECT

Energy Technology Data Exchange (ETDEWEB)

Odano, Ikuo; Takahashi, Naoya; Ohtaki, Hiroh; Noguchi, Eikichi; Hatano, Masayoshi; Yamasaki, Yoshihiro; Nishihara, Mamiko [Niigata Univ. (Japan). School of Medicine; Ohkubo, Masaki; Yokoi, Takashi

1993-10-01

We developed a new graphic method using N-isopropyl-p-[[sup 123]I]iodoamphetamine (IMP) and SPECT of the brain, the graph on which all three parameters, cerebral blood flow, distribution volume (V[sub d]) and delayed count to early count ratio (Delayed/Early ratio), were able to be evaluated simultaneously. The kinetics of [sup 123]I-IMP in the brain was analyzed by a 2-compartment model, and a standard input function was prepared by averaging the time activity curves of [sup 123]I-IMP in arterial blood on 6 patients with small cerebral infarction etc. including 2 normal controls. Being applied this method to the differential diagnosis between Parkinson's disease and progressive supranuclear palsy, we were able to differentiate both with a glance, because the distribution volume of the frontal lobe significantly decreased in Parkinson's disease (Mean[+-]SD; 26[+-]6 ml/g). This method was clinically useful. We think that the distribution volume of [sup 123]I-IMP may reflect its retention mechanism in the brain, and the values are related to amine, especially to dopamine receptors and its metabolism. (author).

A novel cofactor-binding mode in bacterial IMP dehydrogenases explains inhibitor selectivity.

Science.gov (United States)

Makowska-Grzyska, Magdalena; Kim, Youngchang; Maltseva, Natalia; Osipiuk, Jerzy; Gu, Minyi; Zhang, Minjia; Mandapati, Kavitha; Gollapalli, Deviprasad R; Gorla, Suresh Kumar; Hedstrom, Lizbeth; Joachimiak, Andrzej

2015-02-27

The steadily rising frequency of emerging diseases and antibiotic resistance creates an urgent need for new drugs and targets. Inosine 5'-monophosphate dehydrogenase (IMP dehydrogenase or IMPDH) is a promising target for the development of new antimicrobial agents. IMPDH catalyzes the oxidation of IMP to XMP with the concomitant reduction of NAD(+), which is the pivotal step in the biosynthesis of guanine nucleotides. Potent inhibitors of bacterial IMPDHs have been identified that bind in a structurally distinct pocket that is absent in eukaryotic IMPDHs. The physiological role of this pocket was not understood. Here, we report the structures of complexes with different classes of inhibitors of Bacillus anthracis, Campylobacter jejuni, and Clostridium perfringens IMPDHs. These structures in combination with inhibition studies provide important insights into the interactions that modulate selectivity and potency. We also present two structures of the Vibrio cholerae IMPDH in complex with IMP/NAD(+) and XMP/NAD(+). In both structures, the cofactor assumes a dramatically different conformation than reported previously for eukaryotic IMPDHs and other dehydrogenases, with the major change observed for the position of the NAD(+) adenosine moiety. More importantly, this new NAD(+)-binding site involves the same pocket that is utilized by the inhibitors. Thus, the bacterial IMPDH-specific NAD(+)-binding mode helps to rationalize the conformation adopted by several classes of prokaryotic IMPDH inhibitors. These findings offer a potential strategy for further ligand optimization. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

A Novel Cofactor-binding Mode in Bacterial IMP Dehydrogenases Explains Inhibitor Selectivity*

Science.gov (United States)

Makowska-Grzyska, Magdalena; Kim, Youngchang; Maltseva, Natalia; Osipiuk, Jerzy; Gu, Minyi; Zhang, Minjia; Mandapati, Kavitha; Gollapalli, Deviprasad R.; Gorla, Suresh Kumar; Hedstrom, Lizbeth; Joachimiak, Andrzej

2015-01-01

The steadily rising frequency of emerging diseases and antibiotic resistance creates an urgent need for new drugs and targets. Inosine 5′-monophosphate dehydrogenase (IMP dehydrogenase or IMPDH) is a promising target for the development of new antimicrobial agents. IMPDH catalyzes the oxidation of IMP to XMP with the concomitant reduction of NAD+, which is the pivotal step in the biosynthesis of guanine nucleotides. Potent inhibitors of bacterial IMPDHs have been identified that bind in a structurally distinct pocket that is absent in eukaryotic IMPDHs. The physiological role of this pocket was not understood. Here, we report the structures of complexes with different classes of inhibitors of Bacillus anthracis, Campylobacter jejuni, and Clostridium perfringens IMPDHs. These structures in combination with inhibition studies provide important insights into the interactions that modulate selectivity and potency. We also present two structures of the Vibrio cholerae IMPDH in complex with IMP/NAD+ and XMP/NAD+. In both structures, the cofactor assumes a dramatically different conformation than reported previously for eukaryotic IMPDHs and other dehydrogenases, with the major change observed for the position of the NAD+ adenosine moiety. More importantly, this new NAD+-binding site involves the same pocket that is utilized by the inhibitors. Thus, the bacterial IMPDH-specific NAD+-binding mode helps to rationalize the conformation adopted by several classes of prokaryotic IMPDH inhibitors. These findings offer a potential strategy for further ligand optimization. PMID:25572472

Direct comparison study between FDG-PET and IMP-SPECT for diagnosing Alzheimer's disease using 3D-SSP analysis in the same patients

International Nuclear Information System (INIS)

Nihashi, Takashi; Hayasaka, Kazumasa; Yatsuya, Hiroshi

2007-01-01

The purpose of this study was to evaluate and compare the diagnostic ability of 2-[ 18 F]-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) and N-isopropyl-p- 123 I iodoamphetamine single photon emission computed tomography (IMP-SPECT) using three-dimensional stereotactic surface projections (3D-SSP) in patients with moderate Alzheimer's disease (AD). FDG-PET and IMP-SPECT were performed within 3 months in 14 patients with probable moderate AD. Z-score maps of FDG-PET and IMP-SPECT images of a patient were obtained by comparison with data obtained from control subjects. Four expert physicians evaluated and graded the glucose hypometabolism and regional cerebral blood flow (rCBF), focusing in particular on the posterior cingulate gyri/precunei and parietotemporal regions, and determined the reliability for AD. Receiver operating characteristic (ROC) curves were applied to the results for clarification. To evaluate the correlation between two modalities, the regions of interest (ROIs) were set in the posterior cingulate gyri/precunei and parietotemporal region on 3D-SSP images, and mean Z-values were calculated. No significant difference was observed in the area under the ROC curve (AUC) between FDG-PET and IMP-SPECT images (FDG-PET 0.95, IMP-SPECT 0.94). However, a significant difference (P<0.05) was observed in the AUC for the posterior cingulate gyri/precuneus (FDG-PET 0.94, IMP-SPECT 0.81). The sensitivity and specificity of each modality were 86%, and 97% for FDG-PET and 70% and 100% for IMP-SPECT. We could find no significant difference between FDG-PET and IMP-SPECT in terms of diagnosing moderate AD using 3D-SSP. There was a high correlation between the two modalities in the parietotemporal region (Spearman's r=0.82, P<0.001). The correlation in the posterior cingulate gyri/precunei region was lower than that in the parietotemporal region (Spearman's r=0.63, P<0.016). (author)

Radial evolution of the solar wind from IMP 8 to Voyager 2

Science.gov (United States)

Richardson, John D.; Paularena, Karolen I.; Lazarus, Alan J.; Belcher, John W.

1995-01-01

Voyager 2 and Interplanetary Monitoring Platform (IMP) 8 data from 1977 through 1994 are presented and compared. Radial velocity and temperature structures remain intact over the distance from 1 to 43 AU, but density structures do not. Temperature and velocity changes are correlated and nearly in phase at 1 AU, but in the outer heliosphere temperature changes lead velocity changes by tens of days. Solar cycle variations are detected by both spacecraft, with minima in flux density and dynamic pressure near solar maxima. Differences between Voyager 2 and IMP 8 observations near the solar minimum in 1986-1987 are attributed to latitudinal gradients in solar wind properties. Solar rotation variations are often present even at 40 AU. The Voyager 2 temperature profile is best fit with a R(exp -0.49 +/- 0.01) decrease, much less steep than an adiabatic profile.

Effect of donepezil hydrochloride on brain perfusion in patients with dementia of Alzheimer type, evaluated by I-123-IMP SPECT

International Nuclear Information System (INIS)

Ogura, Y.; Narabayashi, I.; Utsunomiya, K.; Komori, T.; Adachi, I.; Sugino, M.; Sakai, J.

2002-01-01

Aim: To evaluate the effects of donepezil hydrochloride on brain perfusion in patients with dementia of Alzheimer type (DAT). Materials and Methods: I-123-IMP SPECT was performed on 12 controls (5 males and 7 females, mean age 69.7±6.4) and 30 consecutive patients with DAT (9 males and 21 females, mean age 71.0±5.1) to assess regional cerebral blood flow (rCBF) using the I-123-IMP autoradiography method. All 30 patients were diagnosed as having DAT by Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria. In 23 of the 30 DAT patients, rCBF in the parietal, occipital, temporal cortex, or hippocampus was decreased more than the control rCBF by 1 SD. These 23 patients were enrolled in this study and received 5 mg/day of donepezil hydrochloride after breakfast. Treatment was continued for 3 to 12 months. At 3 to 6 (DAT/3-6M group) and/or 6 to 12 months (DAT/6-12M group) after the start of the treatment, I-123-IMP SPECT was performed again to obtain the rCBF. Regions of interest were set at the same position in a same patient pair of SPECT images before and after the treatment using an automatic registration tool (ART software, Toshiba, Tokyo, Japan). Results: 10 of the 23 patients in the DAT/3-6M group exhibited improved rCBF. 15 of the 23 patients in the DAT/6-12M group exhibited improved rCBF. These findings were not correlated with the neuropsychological score. Statistically, the rCBF showed no significant difference in the DAT/3-6M group. However, in the DAT/6-12M group, donepezil hydrochloride significantly improved rCBF in the frontal, parietal, and occipital cortices from 25.7±8.7 to 29.3±6.9, 20.6±7.9 to 24.9±6.2, and 27.2±6.0 to 35.0±7.6 [ml/100g/min] respectively. No change, either an increase or a decrease in rCBF was observed in any other regions. Conclusion: Some cases were improved and some cases were not recovered without relationship to the neuropsychological score. Statistically, donepezil hydrochloride did increase r

Embryonic expression of Drosophila IMP in the developing CNS and PNS

DEFF Research Database (Denmark)

Adolph, Sidsel Kramshøj; Delotto, Robert; Nielsen, Finn Cilius

2008-01-01

embryogenesis. In the cellular blastoderm, immunoreactivity was seen in the entire cell-layer, where it was localized apically to the nucleus, and in the pole cells. Later, the GFP-dIMP fusion protein appeared in the developing central nervous system, both in the brain and in the ventral nerve cord...

7. Seminar of the IIE-IMP-ININ on technological specialities. Topic 8: Analytical Chemistry; 7. Seminario IIE-IMP-ININ sobre especialidades tecnologicas. Mesa 8: Quimica Analitica

Energy Technology Data Exchange (ETDEWEB)

NONE

1994-12-31

With the purpose to give continuity to the exchange of experiences and to impel the development of common specialties among IIE-ININ-IMP, the VII Seminary was held in Mexico City on September 7, 1994. In the event were present 163 researchers of the three participant Institutions as well as representative persons of invited institutions. The objective of this Seminary was to relate the researchers of a common branch, with the idea that the specialists made an exchange of experiences, in order to establish cooperation routes. The event was arranged in 11 working tables, with a total of 111 papers: 43 of these papers were from IIE, 42 from IMP, 22 from ININ and 4 from invited entities. During the Seminary, the 11 working tables has sessions simultaneously, and each one of the papers were discussed at the time that possible future cooperating inter institutional actions were examined. The conclusions of the Seminary were exposed in a plenary session, in the presence of the directing boards of the three participant Institutions.

Comment on 'Magnetosheath burst of predominantly medium nuclei observed with Imp 8 on February 16, 1974' by T. P. Armstrong, S. M. Krimigis, and R. P. Lepping

International Nuclear Information System (INIS)

Hovestadt, D.

1980-01-01

Armstrong et al. (1978) report the observation of a unique series of charged particle bursts with an unusually high content of Z>2 particles and a high degree of collimation from the direction of the sun. These bursts were observed only with their CPME (charged particle measurement experiment) instrument on Imp 8, while not with the CPME on Imp 7. No indication has been seen for heavy ion bursts comparable in intensity to those reported by Armstrong et al. (1978) with the ULET (ultralow energy telescope) instrument of the University of Maryland/Max-Planck-Institut experiment on Imp 8 at the same time. It is noted that the ULET counting rates observed on Imp 8 are fully compatible with the CPME rates observed on the Imp 7 spacecraft. We conclude that the CPME and the ULET data from IMP 8 during these periods do not agree, and this casts doubt on the correctness of the CPME results for these special events

Areva in 2006

International Nuclear Information System (INIS)

2007-01-01

This document is the 2006 activity report of the Areva group and presents the 2006 highlights of the nuclear division (front end of the nuclear cycle, pressurized water reactors, treatment and recycling of used nuclear fuel) and of the Transmission and Distribution division. Content: Message from the Chairman of the Supervisory Board; Message from the Chief Executive Officer; the World in 2006; Areva 2006 highlights; business review; key data; Areva around the World; policy of continuous innovation; five years of sustainable development; governance; Continuous improvement; Financial performance; Innovation; Customer satisfaction; Commitment to employees; Environmental protection; Risk management and prevention; Dialogue and consensus building; Community involvement; corporate governance; organization of the group; Share information and shareholder relations; glossary; learn more

A new graphic method for evaluation of distribution volume on N-isopropyl-p-[[sup 123]I]iodoamphetamine (IMP) SPECT

Energy Technology Data Exchange (ETDEWEB)

Odano, Ikuo; Takahashi, Naoya; Ohtaki, Hiroh; Noguchi, Eikichi; Hatano, Masayoshi; Yamasaki, Yoshihiro; Nishihara, Mamiko (Niigata Univ. (Japan). School of Medicine); Ohkubo, Masaki; Yokoi, Takashi

1993-10-01

We developed a new graphic method using N-isopropyl-p-[[sup 123]I]iodoamphetamine (IMP) and SPECT of the brain, the graph on which all three parameters, cerebral blood flow, distribution volume (V[sub d]) and delayed count to early count ratio (Delayed/Early ratio), were able to be evaluated simultaneously. The kinetics of [sup 123]I-IMP in the brain was analyzed by a 2-compartment model, and a standard input function was prepared by averaging the time activity curves of [sup 123]I-IMP in arterial blood on 6 patients with small cerebral infarction etc. including 2 normal controls. Being applied this method to the differential diagnosis between Parkinson's disease and progressive supranuclear palsy, we were able to differentiate both with a glance, because the distribution volume of the frontal lobe significantly decreased in Parkinson's disease (Mean[+-]SD; 26[+-]6 ml/g). This method was clinically useful. We think that the distribution volume of [sup 123]I-IMP may reflect its retention mechanism in the brain, and the values are related to amine, especially to dopamine receptors and its metabolism. (author).

Influência da Impedância e Relutância em Recursos Eletroterapêuticos Utilizados em Tratamentos Fisioterapêuticos

Directory of Open Access Journals (Sweden)

Patrik Nepomuceno

2018-02-01

Full Text Available A eletroterapia consiste no tratamento através de correntes elétricas, ocasionando alterações fisiológicas. Dentro desta terapêutica temos os conceitos de impedância e relutância, temas importantes que devem ser conhecimento do fisioterapeuta. Objetivo: Analisar em dados literários aspectos relevantes à impedância e relutância de uma corrente elétrica nos recursos terapêuticos. Métodos: Foram buscados artigos científicos através de bases de dados, no período de março a junho de 2016. Utilizando palavras-chave como “impedância”, “relutância”, “eletroterapia” e “fisioterapia” e suas traduções para o inglês. Resultados: Nessa perspectiva encontraram-se sete artigos científicos que tratam sobre o assunto impedância, nesse período, e não foram encontrados artigos científicos sobre a relutância. Considerações finais: Diversos mecanismos estão relacionados à impedância da pele e sua redução está associada à sensação agradável relatada pelo paciente e também à efetividade do tratamento. Também é necessário ressaltar a importância para o profissional conhecer os assuntos tratados no presente estudo, pois assim ele poderá aplicar de maneira mais efetiva as correntes excitomotoras, gerando assim uma maior agilidade na terapêutica.

Progress of highly charged atomic physics at IMP

International Nuclear Information System (INIS)

Ma, X; Zhu, X L; Liu, H P; Li, B; Wei, B R; Sha, S; Cao, S P; Chen, L F; Zhang, S F; Feng, W T; Zhang, D C; Qian, D B

2007-01-01

The progress of atomic physics researches at the Institute of Modern Physics (IMP) is reviewed, covering the studies on ion-atom/molecule collisions, ion-cluster interaction, negative ion formation, state-selective electron capture studied by COLTRIMS, as well as the progress of a new experimental area dedicated for atomic researches at moderate energies, and the advances of the cooler storage rings at the Heavy Ion Research Facility in Lanzhou (HIRFL). New opportunities to study collision dynamics from femto-second to atto-second regime are opened based on the present facilities and the on-going projects

The effect of scatter correction on {sup 123}I-IMP brain perfusion SPET with the triple energy window method in normal subjects using SPM analysis

Energy Technology Data Exchange (ETDEWEB)

Shiga, Tohru; Takano, Akihiro; Tsukamoto, Eriko; Tamaki, Nagara [Department of Nuclear Medicine, Hokkaido University School of Medicine, Sapporo (Japan); Kubo, Naoki [Department of Radiological Technology, College of Medical Technology, Hokkaido University, Sapporo (Japan); Kobayashi, Junko; Takeda, Yoji; Nakamura, Fumihiro; Koyama, Tsukasa [Department of Psychiatry and Neurology, Hokkaido University School of Medicine, Sapporo (Japan); Katoh, Chietsugu [Department of Tracer Kinetics, Hokkaido University School of Medicine, Sapporo (Japan)

2002-03-01

Scatter correction (SC) using the triple energy window method (TEW) has recently been applied for brain perfusion single-photon emission tomography (SPET). The aim of this study was to investigate the effect of scatter correction using TEW on N-isopropyl-p-[{sup 123}I]iodoamphetamine ({sup 123}I-IMP) SPET in normal subjects. The study population consisted of 15 right-handed normal subjects. SPET data were acquired from 20 min to 40 min after the injection of 167 MBq of IMP, using a triple-head gamma camera. Images were reconstructed with and without SC. 3D T1-weighted magnetic resonance (MR) images were also obtained with a 1.5-Tesla scanner. First, IMP images with and without SC were co-registered to the 3D MRI. Second, the two co-registered IMP images were normalised using SPM96. A t statistic image for the contrast condition effect was constructed. We investigated areas using a voxel-level threshold of 0.001, with a corrected threshold of 0.05. Compared with results obtained without SC, the IMP distribution with SC was significantly decreased in the peripheral areas of the cerebellum, the cortex and the ventricle, and also in the lateral occipital cortex and the base of the temporal lobe. On the other hand, the IMP distribution with SC was significantly increased in the anterior and posterior cingulate cortex, the insular cortex and the medial part of the thalamus. It is concluded that differences in the IMP distribution with and without SC exist not only in the peripheral areas of the cerebellum, the cortex and the ventricle but also in the occipital lobe, the base of the temporal lobe, the insular cortex, the medial part of the thalamus, and the anterior and posterior cingulate cortex. This needs to be recognised for adequate interpretation of IMP brain perfusion SPET after scatter correction. (orig.)

Aerial Survey Trend Counts of Harbor Seals in Coastal Alaska (1984-2006) - ADF&G

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Aerial surveys were conducted during 1983–2006 in the Ketchikan, Sitka, Kodiak, and Bristol Bay areas of Alaska to estimate trends in abundance of harbor seals.

Cerebral hemodynamic difference between early- and late-onset Alzheimer's disease by circumferential profile analysis with 123I-IMP brain SPECT

International Nuclear Information System (INIS)

Arai, Hisayuki; Hanyu, Haruo; Abe, Shinei; Asano, Tetsuichi; Takasaki, Masaru; Suzuki, Takanari; Abe, Kimihiko; Katsunuma, Hideyo.

1992-01-01

We conducted investigation to determine whether early- and late-onset Alzheimer's diseases differ pathophysiologically. Five patients with the early-onset (65 years and under) of the disease and 11 with the late-onset (65 years and over) of the disease were studied by single photon emission CT (SPECT) with N-isopropyl-p-[ 123 I]iodoamphetamine (IMP). Circumferential profile analysis (CPA) was performed to examine differences in the predominant hypoperfusion in the temporoparietal lobe, which is considered to be functionally damaged the most in Alzheimer's disease. The Xm values, calculated from gradients between the motorsensory or occipital cortices and temporoparietal cortex in the circumferential profile curve, were compared in both groups. The Xm values for patients with early- and late-onset Alzheimer's disease were 6.81±2.10 (counts/degree) and 3.28±1.58, respectively, the difference being significant. Our results suggest that functional abnormalities in the temporoparietal area severer in early- than late-onset Alzheimer's disease and that the application of CPA to IMP SPECT is useful to elucidate the pathophysiological difference between each of the disease. (author)

Investigation of regional cerebral blood flow in alcoholic Korsakoff's syndrome with 123I-IMP SPECT

International Nuclear Information System (INIS)

Nakamura, Makoto; Nomura, Soichiro; Kato, Motoichiro; Nakazawa, Tsuneyuki.

1995-01-01

Regional cerebral blood flow (rCBF) was determined quantitatively by single photon emission computed tomography (SPECT) using N-isopropyl-p-[ 123 I]iodoamphetamine ( 123 I-IMP) in 6 patients with alcoholic Korsakoff's syndrome (A group). The findings were compared with concurrently available findings from 6 alcoholic patients with no evidence of cerebral disordres such as Korsakoff's syndrome and dementia (B group) and 4 healthy persons (C group). In both A and B groups, diffuse decrease in blood flow was significantly observed in the entire brain, as compared with the C group; no significant difference in the decreased blood flow existed between the A and B groups. According to the WAIS results, the patients in the A group were classified as 'typical Korsakoff's syndrome' (full IQ of 90 or more) and as 'serious Korsakoff's syndrome' (full IQ of 89 or less). rCBF in the thalamus was significantly lower in the A group of patients with typical Korsakoff's syndrome than the B group. These findings may reflect the variety of alcoholic Korsakoff's syndrome. This may also have an implication for the possible classification of several types in this syndrome. (N.K.)

Hazardous waste. Annual report, 1984

International Nuclear Information System (INIS)

1985-01-01

Activities in the Hazardous Waste Program area in 1984 ranged from preparing management and long-range plans to arranging training seminars. Past and present generation of hazardous wastes were the key concerns. This report provides a summary of the significant events which took place in 1984. 6 tabs

Regional cerebral blood flow in Parkinson's disease measured with N-isopropyl-p-[123I]iodoamphetamine (IMP) SPECT

International Nuclear Information System (INIS)

Odano, Ikuo; Nishihara, Mamiko; Hayashi, Hiroko; Higuchi, Shoichi; Sakai, Kunio; Ishikawa, Atsushi; Ibayashi, Katsuhiko.

1992-01-01

N-isopropyl-p-[ 123 I]iodoamphetamine (IMP) SPECT studies were performed on 21 patients (13 females; 45-73 yrs) with idiopathic Parkinson's disease (PD) and 10 age-matched normal controls (39-69 yrs). Regional cerebral blood flow (rCBF) was quantitatively measured by the arterial blood sampling method. When compared with normal controls, global CBF, and rCBF in the frontal cortex and in the basal ganglia were reduced 22.1% (p 123 I-IMP SPECT imaging is useful for evaluation and follow-up of patients with PD. (author)

6. Seminar of the IIE-ININ-IMP on technological specialties. Topic 4: dynamics

International Nuclear Information System (INIS)

1992-01-01

The document includes 7 papers presented at the 6. Seminar of the IIE-ININ-IMP (Mexico) on technological specialties in the field of dynamics. (Topic 4). One item was in INIS subject scope and a separate abstract was prepared for it

Comment on 'magnetosheath burst of predominantly medium nuclei observed with Imp 8 on February 16, 1974' by T. P. Armstrong, S. M. Krimigis, and R. P. Lepping

Science.gov (United States)

Hovestadt, D.

1980-01-01

Armstrong et al. (1978) have observed a unique series of bursts with an unusually high content of Z greater than 2 particles and a high degree of collimation from the direction of the sun. The bursts were observed only with the CPME (Charged Particle Measurement Instrument) on Imp 8, but not with the CPME on Imp 7 nor with the ULET (Ultralow Energy Telescope) on Imp 8, whose response characteristics matched those of the CPME on Imp 7. The present comparison of the measurements made with the CPME and ULET cast doubt on the correctness of the reported observations.

EDF - Electricite de France, 2006 annual Results

International Nuclear Information System (INIS)

2007-01-01

The EDF Group is an integrated energy supplier operating in a wide range of electricity-related businesses: generation, transmission, distribution, sale and trading of energy. It is the main operator in the French electricity market and one of the leading electricity groups in Europe. The EDF Group has built a business model balanced between deregulated and regulated operations in France and an international presence. This document is EDF Group's annual Results for 2006. It is made of several reports: the 2006 Annual Results presentation, the 2006 Financial Report, the press releases for the first and third quarters 2006 quarterly financial information, the 2006 Half-year results presentation, the Management Report for the first half 2006, and the consolidated financial statements at 30 June 2006

A new treatment of capillarity to improve the stability of IMPES two-phase flow formulation

KAUST Repository

Kou, Jisheng

2010-12-01

In this paper, we present an efficient numerical method for two-phase immiscible flow in porous media with different capillarity pressures. In highly heterogeneous permeable media, the saturation is discontinuous due to different capillary pressure functions. One popular scheme is to split the system into a pressure and a saturation equation, and to apply IMplicit Pressure Explicit Saturation (IMPES) approach for time stepping. One disadvantage of IMPES is instability resulting from the explicit treatment for capillary pressure. To improve stability, the capillary pressure is usually incorporated in the saturation equation which gradients of saturation appear. This approach, however, does not apply to the case of different capillary pressure functions for multiple rock-types, because of the discontinuity of saturation across rock interfaces. In this paper, we present a new treatment of capillary pressure, which appears implicitly in the pressure equation. Using an approximation of capillary function, we substitute the implicit saturation equation into the pressure equation. The coupled pressure equation will be solved implicitly and followed by the explicit saturation equation. Five numerical examples are provided to demonstrate the advantages of our approach. Comparison shows that our proposed method is more efficient and stable than the classical IMPES approach. © 2010 Elsevier Ltd.

Clinical experience of 123I-IMP scintigraphy in detecting vertebral bone metastases of hepatocellular carcinoma. A comparison with bone scintigraphy with 99mTc-MDP

International Nuclear Information System (INIS)

Suto, Y.; Iwamiya, T.; Tanigawa, N.; Shabana, M.; Ohta, Y.

1994-01-01

123 I-IMP and bone scintigraphy with 99m Tc-MDP were consecutively performed in patients with vertebral bone metastases from hepatocellular carcinoma and lumbar spondylosis deformans in a 7-day interval or shorter. The intensity of uptake was compared. Eighteen of the 20 metastatic lesions (90%) were classified as increased uptake areas in 123 I-IMP scintigraphy. MDP-scintigraphy disclosed 16 metastatic lesions (80%), 9 as ''hot'' lesions (56%) and 7 as ''cold'' lesions (44%). 123 I-IMP scintigraphy was negative in all 12 lesions of lumbar spondylosis deformans. Compared to MDP-scintigraphy, 123 I-IMP scintigraphy was more sensitive in detecting vertebral bone metastases of hepatocellular carcinoma with smaller rates of false-positive and false-negative findings. (orig./MG)

6. Seminar of the IIE-ININ-IMP on technological specialties. Topic 8: computation

International Nuclear Information System (INIS)

1992-01-01

The document includes 10 papers presented at the 6. Seminar of the IIE-ININ-IMP (Mexico) on technological specialties in the field of computation. (Topic 8). Three items were in INIS subject scope and a separate abstract was prepared for each of them

The first interdisciplinary experiments at the IMP high energy microbeam

Energy Technology Data Exchange (ETDEWEB)

Du, Guanghua; Guo, Jinlong; Wu, Ruqun; Guo, Na; Liu, Wenjing; Ye, Fei; Sheng, Lina; Li, Qiang [Institute of Modern Physics (IMP), Chinese Academy of Sciences, Lanzhou (China); Li, Huiyun [Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen (China)

2015-04-01

The high energy beam of tens to hundred MeV/u ions possesses mm-to-cm penetration depth in materials and can be easily extracted into air without significant energy loss and beam scattering. Combination of high energy ions and microbeam technology facilitates the microprobe application to many practical studies in large scale samples. The IMP heavy ion microbeam facility has recently been integrated with microscopic positioning and targeting irradiation system. This paper introduced the first interdisciplinary experiments performed at the IMP microbeam facility using the beam of 80.5 MeV/u carbon ions. Bystander effect induction via medium transferring was not found in the micro-irradiation study using HeLa cells. The mouse irradiation experiment demonstrated that carbon irradiation of 10 Gy dose to its tuberomammillary nucleus did not impair the sleep nerve system. The fault injection attack on RSA (Rivest–Shamir–Adleman) decryption proved that the commercial field-programmable gate array chip is vulnerable in single event effect to low linear-energy-transfer carbon irradiation, and the attack can cause the leakage of RSA private key. This work demonstrates the potential of high energy microbeam in its application to biology, biomedical, radiation hardness, and information security studies.

[123I]-IMP SPECT findings in spinocerebellar ataxia type 6

International Nuclear Information System (INIS)

Ito, Yasuhiko; Nakabayashi, Haruo; Iguchi, Yasuyuki; Suzuki, Masahiko; Kobayashi, Masayuki; Nakajima, Takashi

2000-01-01

To study the dynamics of metabolic function in the cerebellar hemispheres, vermis and brain stem of patients with spinocerebellar ataxia type 6 (SCA6), we used single photon emission computed tomography (SPECT) with N-isopropyl-p-[ 123 I] iodoamphetamine (IMP) to measure regional cerebral blood flow (rCBF) in six Japanese patients with SCA6 and nine normal control subjects. All patients with SCA6 were found to have expanded CAG repeats (from 22 to 24 repeats). The SPECT data were also analyzed semiquantitatively. The rCBF in the cerebellar hemisphere, vermis and brain stem was not significantly lower in patients with SCA6 than in normal controls. However, the ratio of the cerebellar hemisphere to occipital lobe (C/O ratio) was significantly lower in patients. The ratio of the vermis and brain stem to occipital lobe (V/O, P/O ratio) were not significantly lower in patients. The C/O, V/O and P/O ratio were especially sensitive indexes for regional cerebral function in patients with SCA6. Results of this study suggest that the functional decrease in SCA6 may begin in the cerebellar hemispheres. IMP SPECT was useful for evaluating rCBF in patients with SCA6. (author)

Report 1984-1985. Department of Basic Research

International Nuclear Information System (INIS)

1986-01-01

A report is presented of the activities performed by the Department of Basic research of the Bariloche Atomic Center during the period 1984-1985. In this report, works on different subjects related to Physics, are grouped in six sections: Low temperatures, Atomic collisions, Metals, Neutrons and Reactors, Magnetic Resonances and Theory. In addition, a list of publications, made by the Department during said period, is included. (M.E.L.) [es

8. Seminar of the IMP-IIE-ININ on technological specialties. Topic 10: Earth Sciences

International Nuclear Information System (INIS)

1996-01-01

The document contains two papers within INIS subject scope which were presented at the 8th Seminar of the IMP-IIE-ININ on technological specialties. Topic 10: Earth Sciences. A separate abstract was prepared for each paper

Teacher’s action zone in facilitating group dynamics

Directory of Open Access Journals (Sweden)

Dagmara Gałajda

2012-01-01

Full Text Available As believed by many researchers (Dörnyei & Murphey 2003, Hadfield 1992, classroom climate is strongly determined by the dynamics of the learning group and its development over time. For this reason, the role of the teacher in facilitating group processes seems to be of primary importance since it is the teacher who has long been regarded as the group leader in both teacher-centred and learner-centred classrooms.The presentation focuses not only on positive but also on negative forms of classroom dynamics together with management techniques for dealing with conflicts, educational alienation and psychological defensiveness. This, in turn, leads to the concept of facilitator style based on Heron’s (2006 model of facilitation, which consists of six dimensions and three modes. In the paper particular emphasis is placed on the presentation and comparison of various theories of leadership, namely Heron’s system of facilitation, Hersey and Blanchard’s situational-leadership theory (1982 and Bass and Avolio’s transactional versus transformational leadership theory (1984.

[Changes in dental caries indexes in school children in an area of Xochimilco, Mexico: 1984-1992].

Science.gov (United States)

Irigoyen-Camacho, M E; Molina-Feichero, N; Villanueva-Arriaga, R; García-López, S

1995-01-01

To describe the changes in dental caries prevalence and severity, in a group of primary schoolchildren. Two dental caries surveys were carried out, one in 1984 and the other in 1992. The dental caries indices were registered using the World Health Organization's criteria. A group of 6-7 years old schoolchildren living in the East Region of Xochimilco were included in the study. A total of 279 children participated in this study; 153 in 1984 and 126 in 1992. The mean value of the deft index was 5.65 (SD 3.35) in 1984, and the mean value of the deft index was 4.89 (SD 3.7) in 1992. For the permanent dentition the DMFT was 0.51 (SD 1.0) in 1984 and 0.48 (SD 0.82) in 1992. Differences in dental caries indices, between the first and second survey, were significant only for the primary dentition in the six years old group (95% CI 0.36, 2.15). An increase in the proportion of filled teeth was found. However, the treatment needs are still very high (69% for primary teeth and 86% for permanent teeth). The findings from this study seem to indicate little change in the prevalence and severity of dental caries in the population in the period of study.

Annual report 1984

International Nuclear Information System (INIS)

Nuclear power technology, isotope technology and basic research in physics comprises the nuclear activities of Institute for Energy Technology (IFE). In 1984 the Institute entered into an agreement with the present foreign signatories (comprising more than 40 organisations from 10 participating countries) for the continuation of the OECD Halden Project for the three year period from 1985 to 1987. IFE's share of the total budget is appr. 25%. The project's fuel investigations have in 1984 particularly emphasised the characterisation of long term effects with regard to efficiency and operational safety, and the determination of reliability and durability in the case of accident with the loss of cooling water. During 1984 the new experimental reactor control room of the Halden Project was put in operation. The screen based control room, connected to a detailed simulator of a PWR, is intended for experiments in the field of man-machine communication, information presentation, testing of specific systems and training of operators. A testing of alarm systems carried out during 1984 shows that the filtering of alarms is an effective means to ensure that the operator concentrates on the most relevant information during disruptions in the plant operations, and that the use of mimic diagrams facilitates the indentification of alarm situations. Apart from isotope production, the efforts of the isotope laboratories have been concentrated on the development of two completely new radiopharmaceuticals, with the aid of which a blood sample can be marked with a radioactive tracer for the location of abcesses, states of inflammation or blood clots. Research in basic physics has mainly been based on the use of neutron irradiations from the JEEP II reactor for the investigation of the structure and dynamics of solid state materials

Coproduction of KPC-2 and IMP-10 in Carbapenem-Resistant Serratia marcescens Isolates from an Outbreak in a Brazilian Teaching Hospital.

Science.gov (United States)

Silva, Kesia Esther; Cayô, Rodrigo; Carvalhaes, Cecilia Godoy; Patussi Correia Sacchi, Flávia; Rodrigues-Costa, Fernanda; Ramos da Silva, Ana Carolina; Croda, Julio; Gales, Ana Cristina; Simionatto, Simone

2015-07-01

We describe an outbreak caused by KPC-2- and IMP-10-producing Serratia marcescens isolates in a Brazilian teaching hospital. Tigecycline was the only active antimicrobial agent tested. The blaIMP-10 gene was located in a new class 1 integron, named In990, carried by a nonconjugative plasmid, in contrast to blaKPC-2. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Hydrologic design methodologies for small-scale hydro at ungauged sites. Phase 2A, British Columbia. Primer for Integrated Method for Power Analysis (IMP)

Energy Technology Data Exchange (ETDEWEB)

1986-01-01

This report provides a user's manual for the Integrated Method for Power Analysis (IMP) series of programs, developed to aid in evaluating small-scale hydroelectric power sites in British Columbia. The primary objective of IMP is to address the problem posed by hydroelectric development at sites completely lacking in streamflow records. The province's mountainous terrain, with numerous microclimates, precluded methods of regional analysis based on regression or comparisons with gauged streams; instead, a conceptual model of physical processes on the land and in the atmosphere was used as a basis for developing IMP. The IMP package consists of five basic components: an atmospheric model of annual precipitation and 1-in-10-year 24-h maximum rainfall; a watershed model that will generate a daily series of streamflow data; a flood frequency analysis system that uses site-specific topographical information and information from the atmospheric model to generate the flood frequency curve; a hydroelectric power simulation program which determines the daily energy output for a run-of-river or reservoir storage site; and a graphics analysis package which provides direct visualization of atmospheric and streamflow data, and the results of watershed and power simulation modelling. Within each component of the program, the program requirements and capabilities are discussed. A series of sample screens are shown, illustrating the use of the IMP package for a particular simulation. 18 figs., 2 tabs.

Asthma mortality in Uruguay, 1984-1998.

Science.gov (United States)

Baluga, J C; Sueta, A; Ceni, M

2001-08-01

Asthma mortality rates have increased worldwide during the past several years despite the increased availability of new and effective medications. Few studies show reliable data from Latin American countries. To determine asthma mortality rates from 1984 to 1998 and to relate mortality to sales of asthma medications. We conducted a retrospective epidemiologic study in the total population of Uruguay. Data were obtained from the Department of Statistics of the Ministry of Public Health. Trends in mortality rates were analyzed using linear regression procedures. Spearman rank correlations were used to relate mortality rates to sales of asthma medications. The mean overall mortality rate was 5.10 per 100,000 during the period 1984 to 1998, (range 6.08 to 3.39) and showed a decreasing trend (P = 0.001). During the period 1995 to 1998, a more pronounced decrease was observed (mean mortality rate, 4.10 per 100,000). In the 5- to 34-year-old age group the mean mortality rate was 0.43 (range 0.65 to 0.13). Similarly, the mortality rate in this age group decreased particularly in the 1994 to 1998 period (mean 0.19; P = 0.005). Finally, the mortality rate was inversely correlated with sales of inhaled corticosteroids; for the overall mortality rate, p = -0.71, P = 0.003; for 5- to 34-year-old age group, p = -0.63, P = 0.01. Although mortality attributable to asthma seems to be decreasing, the overall mortality rate is still high compared with more economically developed countries. A more pronounced decrease in asthma mortality has been seen in the 5- to 34-year-old group. At present, Uruguay is a Latin American country with a low rate of asthma mortality. This is probably related to the use of new therapies to treat asthma.

Predominance of carbapenem-resistant Pseudomonas aeruginosa isolates carrying blaIMP and blaVIM metallo-β-lactamases in a major hospital in Costa Rica.

Science.gov (United States)

Toval, Francisco; Guzmán-Marte, Anel; Madriz, Vivian; Somogyi, Teresita; Rodríguez, César; García, Fernando

2015-01-01

This study aimed to assess the molecular basis of the resistance to carbapenems in clinical isolates of Pseudomonas aeruginosa recovered from a tertiary-level health facility in San José, Costa Rica. A total of 198 non-duplicated isolates were evaluated for their susceptibility to β-lactams, aminoglycosides and fluoroquinolones. The production of metallo-β-lactamases (MBLs), the presence of MBL encoding genes (blaIMP, blaVIM and blaGIM-1) and the occurrence of these genes within class 1 integrons were investigated. In addition, an ERIC2 PCR fingerprinting method was used to elucidate the distribution of the detected MBL genes within the strain collection. Of the 198 isolates tested, 125 (63.1 %) were categorized as carbapenem-resistant. The majority (88.8 %) of the carbapemen-resistant isolates also showed resistance to ceftazidime, cefepime, aztreonam, ticarcillin/clavulanic acid, amikacin, gentamicin, tobramycin, ciprofloxacin and gatifloxacin. Among the carbapenem-resistant isolates, 102 (81.6 %) showed MBL activity. Strikingly, both blaIMP and blaVIM genes were simultaneously detected in most (94.1 %) of the 102 MBL producers. Five carbapenem-resistant MBL producers were positive only for blaIMP genes. Almost 70 % of the isolates examined harboured the intI1 gene, accompanied by the sul1 and qacEΔ1 genes in 136 (99 %) and 122 (89 %) isolates, respectively. The majority (94.4 %) of the carbapenem-resistant isolates carried the intI1 gene, in contrast to 26 % of the carbapenem-susceptible isolates. Ninety-three out of 96 (96.9 %) isolates carrying both blaIMP and blaVIM genes also harboured the intI1, sul1 and qacEΔ1 genes. Gene cassettes from carbapenem-susceptible and MBL-negative carbapenem-resistant isolates encoded aminoglycoside-resistance enzymes (aadA2, aadA4 and aadA6) as well as orfD and qacF genes. RAPD analysis distributed 126 of the isolates in 29 clusters. Eighty of the 90 blaIMP (+) blaVIM (+) isolates were sorted into 16

Cerebral blood flow measurement using 123I-IMP graph plot method with SPECT. Comparison with autoradiography method

International Nuclear Information System (INIS)

Shinohara, Yuki; Kamitani, Hideki; Ishibashi, Minako; Ito, Satoru; Ogawa, Toshihide

2011-01-01

The purpose of this study was to evaluate quantification of cerebral blood flow (CBF) values using 123 I-iodoamphetamine (IMP) graph plot (GP) method with single photon emission computed tomography (SPECT), compared with autoradiography (ARG) method. IMP-SPECT by GP combined with ARG method at rest was performed in 40 patients to determine the equation of linear regression for GP method in our institution. In addition, we compared regional CBF (rCBF) values at rest between GP and ARG methods in 10 other patients. Among all 50 patients, acetazolamide (ACZ)-challenged SPECT by GP combined with ARG method using 2-day protocol was performed in 10 patients. We also compared the rCBF values after ACZ challenge between GP and ARG methods in these 10 patients. The equation of linear regression for GP method in our institution was y=1.945x+20.36 (R 2 =0.586, P 2 =0.624, P 2 =0.150, P<0.001). IMP-SPECT by GP method at rest is useful to measure reliable rCBF values without arterial blood sampling, although we need pay attention to interpret the result of 2-day protocol ACZ-challenged SPECT by GP method. (author)

6. Seminar of the IIE-ININ-IMP on technological specialties. Topic 7: energy savings

International Nuclear Information System (INIS)

1992-01-01

The document includes 6 papers presented at the 6. Seminar of the IIE-ININ-IMP (Mexico) on technological specialties in the field of energy savings. (Topic 7). One item was in INIS subject scope and a separate abstract was prepared for it

Clear cell carcinomas of the ovary: a mono-institutional study of 73 cases in China with an analysis of the prognostic significance of clinicopathological parameters and IMP3 expression.

Science.gov (United States)

Bi, Rui; Shen, Xuxia; Zhang, Weiwei; Cheng, Yufan; Feng, Zheng; Cai, Xu; Yang, Wentao

2016-02-02

Ovarian clear cell carcinoma (CCC) is an uncommon subtype of ovarian epithelial tumor. The prognostic significance of its clinicopathological parameters is discordant, with the exception of stage as the adverse prognostic factor. The present study aimed to evaluate the prognostic significance of its clinicopathological characteristics and the expression of IMP3 (Insulin-like growth factor-II mRNA-binding protein 3, IMP3 or IGF2BP3) in Chinese patients with primary pure CCC. We collected clinicopathological data from 73 cases with a minimum of 5 years of follow-up and evaluated the expression of IMP3 by immunohistochemistry. In total, 49.3 % of the patients were in stage I. Advanced stages were closely related to poor prognosis of disease-free survival (DFS) and overall survival (OS) (P 73 cases); Thus, positive expression of IMP3 is an adverse prognostic marker in terms of OS (P = 0.012), even in stage I patients (P = 0.038). The present study demonstrates that IMP3 expression is a prognostic marker, with the exception of stage. IMP3 represents a biomarker of unfavorable prognosis even in stage I patients.

Open-ended and Open-door Treatment Groups for Young People with Mental Illness.

Science.gov (United States)

Miller, Rachel; Mason, Susan E

2012-01-01

The concept of open-ended groups is expanded to include an open-door model (OEOD) wherein members with severe mental illnesses, including schizophrenia disorders and bi-polar, can join, leave, and re-enter groups as their life circumstances dictate their availability and willingness for treatment. This model is grounded on the work of Schopler and Galinsky's (1984/2006) and Galinsky and Schopler's (1989) theses on the value and processes of open-ended groups and includes perspectives on mutual aid and group development. Groupwork with the OEOD format is illustrated with examples taken from a group of 79 participants diagnosed with first-episode schizophrenia/schizoaffective disorders, 40 of who had co-occurring substance abuse. Of the 79 participants in the OEOD group program, 70 (89%) remained in treatment for the maximum of 3 years. The over-all value of group treatment for this population is reviewed along with the small number of available publications on open-ended and open-door-type groups.

7. Seminar of the IIE-ININ-IMP on technological specialties. Topic 10: Information Services

International Nuclear Information System (INIS)

1994-01-01

The document includes 10 papers presented at the 7. Seminar of the IIE-IMP-ININ (Mexico) on technological specialities in the field of information services (Topic 10). Three items were in INIS subject scope and a separate abstract was prepared for each of them

6. Seminar of the IIE-ININ-IMP on technological specialties. Topic 13: earth sciences

International Nuclear Information System (INIS)

1992-01-01

The document includes 12 papers presented at the 6. Seminar of the IIE-ININ-IMP (Mexico) on technological specialties in the field of earth sciences. (Topic 13). Four items were in INIS subject scope and a separate abstract was prepared for each of them

Impôts, taxes et équité entre les sexes : codes, comportements et ...

International Development Research Centre (IDRC) Digital Library (Canada)

6 déc. 2010 ... On sait que les impôts et la taxation peuvent favoriser l'égalité socioéconomique, mais ... Analysis of Direct and Indirect Taxes in Developing and Developed Countries. ... Gender and taxation in South Africa: a policy brief.

Elevated expression of the IGF2 mRNA binding protein 2 (IGF2BP2/IMP2) is linked to short survival and metastasis in esophageal adenocarcinoma

OpenAIRE

Barghash, Ahmad; Golob-Schwarzl, Nicole; Helms, Volkhard; Haybaeck, Johannes; Kessler, Sonja M.

2016-01-01

Esophageal adenocarcinoma (EAC) represents the sixth leading cause of cancer-related deaths and develops in Barret's esophagus affected tissues. The IGF2 mRNA binding protein IMP2/IGF2BP2/p62 was originally identified as an autoantigen in hepatocellular carcinoma. Aim of this study was to investigate the expression and prognostic role of IMP2 in EAC. Human EAC and Barret's esophagus tissue showed overexpression of IMP2, particularly in tumors of increased size and in metastatic tissues. Molec...

Annual status report 31 December 1984

International Nuclear Information System (INIS)

1985-04-01

The research work of the Institute for Plasma Physics at Rijnhuizen during 1984 is surveyed. The Experimental Division reports on: pinches; turbulent heating in TORTUR, a small tokamak; numerical calculations on cold plasma blankets; electron cyclotron resonance heating; and, diagnostic subsystems. The Theoretical Division reports on: magnetohydrodynamics, wave dynamics and transport problems. Finally, the groups of the Department of Technology and Engineering report on subjects as: design, construction and maintenance of instruments and apparatus, for instance the high-voltage supply of SPICA II and TORTUR III, electronic control and computer hardware and software

Investigation of regional cerebral blood flow in alcoholic Korsakoff`s syndrome with {sup 123}I-IMP SPECT

Energy Technology Data Exchange (ETDEWEB)

Nakamura, Makoto; Nomura, Soichiro [Tachikawa Hospital, Tokyo (Japan); Kato, Motoichiro; Nakazawa, Tsuneyuki

1995-05-01

Regional cerebral blood flow (rCBF) was determined quantitatively by single photon emission computed tomography (SPECT) using N-isopropyl-p-[{sup 123}I]iodoamphetamine ({sup 123}I-IMP) in 6 patients with alcoholic Korsakoff`s syndrome (A group). The findings were compared with concurrently available findings from 6 alcoholic patients with no evidence of cerebral disordres such as Korsakoff`s syndrome and dementia (B group) and 4 healthy persons (C group). In both A and B groups, diffuse decrease in blood flow was significantly observed in the entire brain, as compared with the C group; no significant difference in the decreased blood flow existed between the A and B groups. According to the WAIS results, the patients in the A group were classified as `typical Korsakoff`s syndrome` (full IQ of 90 or more) and as `serious Korsakoff`s syndrome` (full IQ of 89 or less). rCBF in the thalamus was significantly lower in the A group of patients with typical Korsakoff`s syndrome than the B group. These findings may reflect the variety of alcoholic Korsakoff`s syndrome. This may also have an implication for the possible classification of several types in this syndrome. (N.K.).

Clinical experience of [sup 123]I-IMP scintigraphy in detecting vertebral bone metastases of hepatocellular carcinoma. A comparison with bone scintigraphy with [sup 99m]Tc-MDP

Energy Technology Data Exchange (ETDEWEB)

Suto, Y. (Dept. of Radiology, Tottori Univ. Faculty of Medicine, Yonago (Japan) Dept. of Radiology, Matsue City Hospital (Japan)); Iwamiya, T. (Dept. of Radiology, Tottori Univ. Faculty of Medicine, Yonago (Japan) Dept. of Radiology, Matsue City Hospital (Japan)); Tanigawa, N. (Dept. of Radiology, Tottori Univ. Faculty of Medicine, Yonago (Japan) Dept. of Radiology, Matsue City Hospital (Japan)); Shabana, M. (Dept. of Radiology, Tottori Univ. Faculty of Medicine, Yonago (Japan) Dept. of Radiology, Matsue City Hospital (Japan)); Ohta, Y. (Dept. of Radiology, Tottori Univ. Faculty of Medicine, Yonago (Japan) Dept. of Radiology, Matsue City Hospital (Japan))

1994-03-01

[sup 123]I-IMP and bone scintigraphy with [sup 99m]Tc-MDP were consecutively performed in patients with vertebral bone metastases from hepatocellular carcinoma and lumbar spondylosis deformans in a 7-day interval or shorter. The intensity of uptake was compared. Eighteen of the 20 metastatic lesions (90%) were classified as increased uptake areas in [sup 123]I-IMP scintigraphy. MDP-scintigraphy disclosed 16 metastatic lesions (80%), 9 as ''hot'' lesions (56%) and 7 as ''cold'' lesions (44%). [sup 123]I-IMP scintigraphy was negative in all 12 lesions of lumbar spondylosis deformans. Compared to MDP-scintigraphy, [sup 123]I-IMP scintigraphy was more sensitive in detecting vertebral bone metastases of hepatocellular carcinoma with smaller rates of false-positive and false-negative findings. (orig./MG).

People and things. CERN Courier, Mar 1984, v. 24(2)

Energy Technology Data Exchange (ETDEWEB)

Anon.

1984-03-15

The article reports on achievements of various people, staff changes and position opportunities within the CERN organization and contains news updates on upcoming or past events. Some time ago, Wolfgang ('Pief') Panofsky, Director of SLAC since 1961 and one of the prime movers behind both the famous two-mile electron linac and the Laboratory itself, announced his intention to step down in 1984. Immediately a search began for a worthy successor. Carlo Rubbia, leader of the UA 1 experiment at CERN which last year discovered the W and Z particles, was named by the US science magazine 'Discover' as its 1983 'Scientist of the Year'. A CERN-ECFA Workshop to study the feasibility of hadron colliders which it might at some time in the future be possible to install in the LEP tunnel, is to be held at the University of Lausanne from 21-24 March. Fermilab will host the 1984 US Summer School on High Energy Particle Accelerators from 13-24 August - the fourth in this series of summer schools.The 1984 CERN School of Computing, the eighth in the biennial series, is being organized in collaboration with the Instituto Estudios Energeticos (Junta de Energia Nuclear, Madrid) and the Facultad de Informatica, Barcelona, and will be held from 9-22 September at Aiguablava, Spain. The 1984 Users' Meeting of the High Energy Discussion Group (HEDG) at Brookhaven on 29-31 March will include a Workshop on the possible physics from an improved Alternating Gradient Synchrotron.

Diagnosis of Alzheimer's disease and multiple infarct dementia by tomographic imaging of iodine-123 IMP

International Nuclear Information System (INIS)

Cohen, M.B.; Graham, L.S.; Lake, R.

1986-01-01

Tomographic imaging of the brain was performed using a rotating slant hole collimator and [ 123 I]N-isopropyl p-iodoamphetamine (IMP) in normal subjects (n = 6) and patients with either Alzheimer's disease (n = 5) or multiple infarct dementia (n = 3). Four blinded observers were asked to make a diagnosis from the images. Normal subjects and patients with multiple infarct dementia were correctly identified. Alzheimer's disease was diagnosed in three of the five patients with this disease. One patient with early Alzheimer's disease was classified as normal by two of the four observers. Another patient with Alzheimer's disease had an asymmetric distribution of IMP and was incorrectly diagnosed as multiple infarct dementia by all four observers. Limited angle tomography of the cerebral distribution of 123 I appears to be a useful technique for the evaluation of demented patients

[Development Of 25-Year Imp 8 Bow Shock Crossing "List, Ingestion Of This List To Cdaweb, & Enhancement"

Science.gov (United States)

Merka, J.; Szabo, A.; Narock, T. W.; King, J. H.; Paularena, K. I.; Richardson, J. D.

2003-01-01

The MIT portion of this project was to use the plasma data from IMP 8 to identify bow shock crossings for construction of a bow shock data base. In collaboration with Goddard, we determined which shock parameters would be included in the catalog and developed a set of flags for characterizing the data. IMP 8 data from 1973-2001 were surveyed for bow shock crossings; the crossings apparent in the plasma data were compared to a list of crossing chosen in the magnetometer data by Goddard. Differences were reconciled to produce a single list. The data were then provided to the NSSDC for archiving. All the work ascribed to MIT in the proposal was completed.

6. Seminar of the IIE-ININ-IMP on technological specialties. Topic 3: thermal fluids

International Nuclear Information System (INIS)

1992-01-01

The document includes 10 papers presented at the 6. Seminar of the IIE-ININ-IMP (Mexico) on technological specialties in the field of thermal fluids. (Topic 3). From these, 4 papers were in INIS subject scope and a separate abstract was prepared for each of them

6. Seminar of the IIE-ININ-IMP on technological specialties. Topic 6: environmental contamination

International Nuclear Information System (INIS)

1992-01-01

The document includes 10 papers presented at the 6. Seminar of the IIE-ININ-IMP on technological specialities in the field of environmental contamination (Topic 6). From these, 6 papers were in INIS subject scope and a separate abstract was prepared for each of these papers

Youth Homelessness 2006

Science.gov (United States)

MacKenzie, David; Chamberlain, Chris

2008-01-01

The third national census of homeless school students, conducted in 2006, found that the number of homeless students had decreased since 2001. There were 9,389 homeless students in 2006 compared with 12,227 in 2001. Three groups were over-represented in the homeless population: Indigenous students, young people from single parent and blended…

Evaluation of SPECT with N-isopropyl[I-123]-p-iodoamphetamine (IMP) in epileptic patients

International Nuclear Information System (INIS)

Nambu, Toshikazu; Itoh, Kazuo; Sumi, Tetsuo; Furudate, Masayori; Irie, Goro

1988-01-01

Brain SPECT scintigrams with N-Isopropyl[I-123]-p-Iodoamphetamine (IMP) were reviewed and compared with the EEG findings in 21 epileptic patients (22 SPECT images) with normal CT. Thirteen of 22 SPECT images showed abnormal low uptake and 7 of them corresponded to the EEG focus. In order to obtain the quantitative analysis, the count ratio of the focus side to the opposite I-123 content in fixed ROI was measured for each case, but no statistically significant correlation for the frequency or the duration of epilepsy was found. EEG is not considered to be favorite standard for localizing epileptic foci, especially in deep cerebral region, and that may be one of the main reason for the incomplete correlation. In the qualitative study, however, the cases with frequent epileptic attack were more likely to show abnormal findings. I-123 IMP SPECT can now be considered as having a significant clinical role for the diagnosis and management of patients with epilepsy. (author)

Regional cerebral blood flow study with 123I-IMP in patients with degenerative dementia

International Nuclear Information System (INIS)

Ohnishi, T.; Hoshi, H.; Nagamachi, S.; Jinnouchi, S.; Futami, S.; Watanabe, K.; Mitsuyama, Y.

1991-01-01

Regional cerebral blood flow was evaluated by single-photon emission CT (SPECT) with 123I-N-isopropyl-p-iodoamphetamine (123I-IMP) in 11 patients with dementia of the Alzheimer type, three patients with progressive dementia and motor neuron disease, and eight healthy control subjects. Regional blood flow measurements in the bilateral frontal, parietal association, and temporal cortices were lower in the Alzheimer dementia patients than in controls. Flow deficits in the parietal association cortex were demonstrated in all patients with Alzheimer-type dementia; these deficits were correlated with the severity of disease. Lateral hemispheric asymmetry was seen in nine of 11 patients with Alzheimer-type dementia. In all three patients with progressive dementia and motor neuron disease, flow deficits were demonstrated in the bilateral frontal and temporal cortices, but no flow deficits were seen in the parietal association cortex. Brain SPECT with 123I-IMP may be useful in the differential diagnosis and evaluation of the severity of degenerative dementia

Status of safety at Areva group facilities. 2006 annual report

International Nuclear Information System (INIS)

2006-01-01

This report presents a snapshot of nuclear safety and radiation protection conditions in the AREVA group's nuclear installations in France and abroad, as well as of radiation protection aspects in service activities, as identified over the course of the annual inspections and analyses program carried out by the General Inspectorate in 2006. This report is presented to the AREVA Supervisory Board, communicated to the labor representation bodies concerned, and made public. In light of the inspections, appraisals and coordination missions it has performed, the General Inspectorate considers that the nuclear safety level of the AREVA group's nuclear installations is satisfactory. It particularly noted positive changes on numerous sites and efforts in the field of continuous improvement that have helped to strengthen nuclear safety. This has been possible through the full involvement of management teams, an improvement effort initiated by upper management, actions to increase personnel awareness of nuclear safety culture, and supervisors' heightened presence around operators. However, the occurrence of certain events in facilities has led us to question the nuclear safety repercussions that the changes to activities or organization on some sites have had. In these times of change, drifts in nuclear safety culture have been identified. The General Inspectorate considers that a preliminary analysis of the human and organizational factors of these changes, sized to match the impact the change has on nuclear safety, should be made to ensure that a guaranteed level of nuclear safety is maintained (allowance for changes to references, availability of the necessary skills, resources of the operating and support structures, etc.). Preparations should also be made to monitor the changes and spot any telltale signs of drift in the application phase. Managers should be extra vigilant and the occurrence of any drift should be systematically dealt with ahead of implementing

Progress report 1984

International Nuclear Information System (INIS)

1984-01-01

This report of the Ankara Nuclear Research and Training Center gives a general survey of the activities and research work done in 1984. The research areas are: Physics, Chemistry, Health Physics, Electronics and Nuclear Information. (author)

1984 Ordinance on nuclear activities (1984:14)

International Nuclear Information System (INIS)

1984-01-01

This Supplementary Ordinance on Nuclear Activities (1984:14) sets out a regulatory regime for the conveyance out of Sweden of equipment or material that has been specially designed or prepared for the processing, use or production of nuclear substances or which is otherwise of essential importance for the production of nuclear devices. The Annex to the Ordinance sets out the list of such equipment or material whose export is subject to Government authorisation. (NEA) [fr

8. Seminar of the IMP-IIE-ININ on technological specialties. Topic 9: Analytical Chemistry

International Nuclear Information System (INIS)

1996-01-01

The document includes four papers considered within the INIS subject scope, which were presented at the 8th Seminar of the IMP-IIE-ININ on technological specialities (Section Analytical Chemistry), held on 26 June 1996 in Cuernavaca (Mexico). A separate abstract and indexing were provided for each paper

Uranium Industry. Annual 1984

International Nuclear Information System (INIS)

Lawrence, M.S.S.

1985-01-01

This report provides a statistical description of activities of the US uranium industry during 1984 and includes a statistical profile of the status of the industry at the end of 1984. It is based on the results of an Energy Information Administration (EIA) survey entitled ''Uranium Industry Annual Survey'' (Form EIA-858). The principal findings of the survey are summarized under two headings - Uranium Raw Materials Activities and Uranium Marketing Activities. The first heading covers exploration and development, uranium resources, mine and mill production, and employment. The second heading covers uranium deliveries and delivery commitments, uranium prices, foreign trade in uranium, inventories, and other marketing activities. 32 figs., 48 tabs

EDF - 2006 full-year results, 2006 Financial report

International Nuclear Information System (INIS)

Gadonneix, Pierre

2007-04-01

As the world's biggest electricity generator, the EDF Group covers every sector of expertise, from generation to trading and transmission grids. EDF builds on the expertise of its people, its R and D and engineering skills, its experience as a leading industry operator and the attentive support of its customers to deliver competitive solutions that successfully reconcile economic growth with climate protection. This document presents the 2006 annual results and Consolidated financial statements of the Group at 31 December 2006: Consolidated income statements, Consolidated balance sheets, Consolidated cash flow statements, Changes in consolidated equity, Notes: Group accounting policies, Summary of accounting and valuation methods, Public distribution concessions in France, Comparability, Significant events and transactions of 2006 and 2005, Changes in the scope of consolidation, Segment reporting, Sales, Fuel and energy purchases, Other external expenses, Contractual obligations and commitments, Personnel expenses, Other operating income and expenses, Impairments / reversals, Other income and expenses, Financial result, Income taxes, Goodwill, Other intangible assets, Property, plant and equipment, Investments in companies accounted for under the equity method, Financial assets, Inventories including work-in-process, Trade receivables, Other receivables, Cash and cash equivalents, Held-for-sale assets and liabilities, Equity, Provisions, Special concession liabilities, Current and non-current financial liabilities, Derivatives, Other liabilities, Contribution of joint ventures, Related parties, Environment, Subsequent events, Transition to standards IAS 32 and 39 concerning financial instruments, Scope of consolidation

Demographic Change in the American Geophysical Union's United States Membership, 2006-2014

Science.gov (United States)

Rhodes, D. D.

2014-12-01

AGU's demographic characteristics changed during the period 2006-2014 in response to the aging of the Baby Boom generation and an increase in the number of women geoscientists. This analysis deals only with the portion of AGU's membership with mailing addresses within the US, a group that comprised 65% of the worldwide total in 2006 and 61% of the total membership in 2014. Using the US membership data that include both the members' birthdate and gender, a comparison of the population structures in 2006 and 2014 reveals characteristics of the changing US workforce. Since 2006, the percent of the US membership represented by the Baby Boom has decreased 5.2%, from 37.2% to 32.0%. That trend will continue for the next 20 years and the rate will accelerate before slowing again. At the same time the Boomers are decreasing in number, the percentage of the membership represented by the more recent age-cohorts (born 1965-1989) has grown. For example, in 2006, the 1985-1989 cohort was barely represented (0.14%). By February 2014, the cohort had become 8.25% of the U.S. membership. The four cohorts covering birth years 1965 through 1984, each increased slightly in size. In addition, each had a larger number of women, reflecting AGU's increased female membership from 22.5% to 25.3%. The 1985-1989 cohort is somewhat smaller than the previous four cohorts. If the smaller size of this represents a reversal of the growth trend over the last 25 years, the implications for the size of the US workforce are important. Perhaps the most significant change in the demographic structure of AGU's US membership is that the general shape of the age-gender diagram, while still asymmetrical because of the larger number of men, is becoming more straight sided due to the similar size of recent cohorts. This shape is characteristic of stable populations when dealing with self-reproducing groups. The implications for the future of a scientific society are less clear, but the cause reflects a period

Joseph Roth, tradutor do Império perdido

Directory of Open Access Journals (Sweden)

Luis S. Krausz

2015-06-01

Full Text Available Este artigo discute um folhetim jornalístico do escritor austríaco Joseph Roth que trata de uma miniatura do Templo de Salomão, encontrada por ele num café da Hirtenstrasse berlinense, no coração do que foi, na década de 1920, o bairro habitado pelos judeus do Leste da Europa na capital alemã. A nostalgia, sob cujo signo foi criada tal miniatura, torna-se uma metáfora da nostalgia pelo império Austro-Húngaro, chave para a compreensão da obra romanesca deste escritor. Ao mesmo tempo, esta nostalgia rothiana é contextualizada no âmbito das crenças místicas e messiânicas do judaísmo tradicional.

People and things. CERN Courier, Mar 1984, v. 24(2)

International Nuclear Information System (INIS)

Anon.

1984-01-01

The article reports on achievements of various people, staff changes and position opportunities within the CERN organization and contains news updates on upcoming or past events. Some time ago, Wolfgang ('Pief') Panofsky, Director of SLAC since 1961 and one of the prime movers behind both the famous two-mile electron linac and the Laboratory itself, announced his intention to step down in 1984. Immediately a search began for a worthy successor. Carlo Rubbia, leader of the UA 1 experiment at CERN which last year discovered the W and Z particles, was named by the US science magazine 'Discover' as its 1983 'Scientist of the Year'. A CERN-ECFA Workshop to study the feasibility of hadron colliders which it might at some time in the future be possible to install in the LEP tunnel, is to be held at the University of Lausanne from 21-24 March. Fermilab will host the 1984 US Summer School on High Energy Particle Accelerators from 13-24 August - the fourth in this series of summer schools.The 1984 CERN School of Computing, the eighth in the biennial series, is being organized in collaboration with the Instituto Estudios Energeticos (Junta de Energia Nuclear, Madrid) and the Facultad de Informatica, Barcelona, and will be held from 9-22 September at Aiguablava, Spain. The 1984 Users' Meeting of the High Energy Discussion Group (HEDG) at Brookhaven on 29-31 March will include a Workshop on the possible physics from an improved Alternating Gradient Synchrotron

Overexpression of the OsIMP Gene Increases the Accumulation of Inositol and Confers Enhanced Cold Tolerance in Tobacco through Modulation of the Antioxidant Enzymes' Activities.

Science.gov (United States)

Zhang, Rong-Xiang; Qin, Li-Jun; Zhao, De-Gang

2017-07-20

Inositol is a cyclic polyol that is involved in various physiological processes, including signal transduction and stress adaptation in plants. l- myo -inositol monophosphatase (IMPase) is one of the metal-dependent phosphatase family members and catalyzes the last reaction step of biosynthesis of inositol. Although increased IMPase activity induced by abiotic stress has been reported in chickpea plants, the role and regulation of the IMP gene in rice ( Oryza sativa L.) remains poorly understood. In the present work, we obtained a full-length cDNA sequence coding IMPase in the cold tolerant rice landraces in Gaogonggui, which is named as OsIMP . Multiple alignment results have displayed that this sequence has characteristic signature motifs and conserved enzyme active sites of the phosphatase super family. Phylogenetic analysis showed that IMPase is most closely related to that of the wild rice Oryza brachyantha , while transcript analysis revealed that the expression of the OsIMP is significantly induced by cold stress and exogenous abscisic acid (ABA) treatment. Meanwhile, we cloned the 5' flanking promoter sequence of the OsIMP gene and identified several important cis -acting elements, such as LTR (low-temperature responsiveness), TCA-element (salicylic acid responsiveness), ABRE-element (abscisic acid responsiveness), GARE-motif (gibberellin responsive), MBS (MYB Binding Site) and other cis -acting elements related to defense and stress responsiveness. To further investigate the potential function of the OsIMP gene, we generated transgenic tobacco plants overexpressing the OsIMP gene and the cold tolerance test indicated that these transgenic tobacco plants exhibit improved cold tolerance. Furthermore, transgenic tobacco plants have a lower level of hydrogen peroxide (H₂O₂) and malondialdehyde (MDA), and a higher content of total chlorophyll as well as increased antioxidant enzyme activities of superoxide dismutase (SOD), catalase (CAT) and peroxidase (POD

Deutsches Atomforum e.V. annual report 1984

International Nuclear Information System (INIS)

1985-01-01

A report on the various activities and tasks of Deutsches Atomforum (German Forum of Atomics) in 1984, including analyses, information and statements on the peaceful utilization of nuclear energy. It contains the most important data on nuclear energy in 1984, organs of and events organized by Deutsches Atomforum; operational results of power plants; total electricity generation in German power plants in 1984 rose by 40% compared to the previous year; discussion of key points in the sectors engineering and industry, public relations and press, legal affairs and administration, economy and industry, international cooperation. Information on activities of the financing society for nuclear reactors is supplied as well. (HSCH) [de

Gyral high density on CT scan after head injury; [sup 123]I-IMP SPECT and MRI findings in three children

Energy Technology Data Exchange (ETDEWEB)

Abe, Takumi; Matsumoto, Kiyoshi (Showa Univ., Tokyo (Japan). School of Medicine); Sakamoto, Tetsuya; Aruga, Tohru

1994-02-01

The authors treated three children who had 'gyral high density' on plain CT scans after head injury with acute subdural hematoma. [sup 123]I-IMP SPECT (IMP) and MRI in the chronic stage were performed. All were males, about one year of age, with acute subdural hematoma. CT scan 48 hours after injury showed diffuse low density in the ipsilateral parenchyma with minimum midline shift, and IMP showed decreased activity in the same area. Plain CT scan 1 to 3 weeks after injury showed remarkably high density along the gyri in part of the same area. This area was markedly enhanced on CT with contrast medium and showed decreased blood flow on IMP. This high density area disappeared within 2 months after injury and the area concerned showed brain atrophy. In the chronic stage (after 6 months), only the high density area along the gyri seen in the CT scan showed MRI evidence of ishemia, but there was no definite evidence of hemorrhage. All three children had hemiplegia at the time of discharge. The gyral high density suggests ischemic brain, but the pathophysiological process might be different from that of so-called hemorrhagic infarction. Presumably, it is due to incomplete autoregulation, the incomplete blood-brain barrier and the sensitivity to stimulation of cerebral blood vessels in the brains of infants. The intensity and range of the gyral high density are considered to be important in estimating the future amount of atrophic change in the insulted brain and the resulting sequelae. (author).

Costs to build Fermilab in 1984 dollars

International Nuclear Information System (INIS)

Jordan, N.G.; Livdahl, P.V.

1984-02-01

It is of current interest to examine the costs incurred to date to build Fermi National Accelerator Laboratory and to determine what those costs are when stated in FY 1984 constant dollars. The appended tables are in support of this exercise and are based on all costs for Equipment items (reduced by obsolescence) and all Plant Projects which have been appropriated through FY 1984. Also included are non-plant costs which are required to complete the Energy Saver, Tevatron I and II projects (i.e., Equipment and R and D in support of Construction). This study makes the assumption that all funding through FY 1984 will have been costed by the end of FY 1986. Those costs incurred in FY 1985 and FY 1986 have been deflated to FY 1984 dollars. See Appendix A for the DOE inflation factors used in the conversion to FY 1984 dollars. The costs are identified in three categories. The Accelerator Facilities include all accelerator components, the buildings which enclose them and utilities which support them. The Experimental Facilities include all beam lines, enclosures, utilities and experimental equipment which are usable in current experimental programs. The Support Facilities include lab and office space, shops, assembly facilities, roads, grounds and the utilities which do not specifically support the Accelerator or Experimental Facilities, etc

7. Seminar of the IIE-IMP-ININ on technological specialities. Topic 8: Analytical Chemistry

International Nuclear Information System (INIS)

1994-01-01

With the purpose to give continuity to the exchange of experiences and to impel the development of common specialties among IIE-ININ-IMP, the VII Seminary was held in Mexico City on September 7, 1994. In the event were present 163 researchers of the three participant Institutions as well as representative persons of invited institutions. The objective of this Seminary was to relate the researchers of a common branch, with the idea that the specialists made an exchange of experiences, in order to establish cooperation routes. The event was arranged in 11 working tables, with a total of 111 papers: 43 of these papers were from IIE, 42 from IMP, 22 from ININ and 4 from invited entities. During the Seminary, the 11 working tables has sessions simultaneously, and each one of the papers were discussed at the time that possible future cooperating inter institutional actions were examined. The conclusions of the Seminary were exposed in a plenary session, in the presence of the directing boards of the three participant Institutions

Annual report 1984

International Nuclear Information System (INIS)

1986-01-01

Advances and achievements of the Argentine Nuclear Program during 1984 are distributed into the following sections: Nuclear Power Plants, Supplies to Nuclear Power Plants, Radioisotopes and Radiations, Radiological Protection and Nuclear Safety, Research and Development, and Infraestructure and General Aspects. (M.E.L.) [es

The IGFBP7 homolog Imp-L2 promotes insulin signaling in distinct neurons of the Drosophila brain.

Science.gov (United States)

Bader, R; Sarraf-Zadeh, L; Peters, M; Moderau, N; Stocker, H; Köhler, K; Pankratz, M J; Hafen, E

2013-06-15

In Drosophila, Insulin-like peptide 2 (Dilp-2) is expressed by insulin-producing cells in the brain, and is secreted into the hemolymph to activate insulin signaling systemically. Within the brain, however, a more local activation of insulin signaling may be required to couple behavioral and physiological traits to nutritional inputs. We show that a small subset of neurons in the larval brain has high Dilp-2-mediated insulin signaling activity. This local insulin signaling activation is accompanied by selective Dilp-2 uptake and depends on the expression of the Imaginal morphogenesis protein-late 2 (Imp-L2) in the target neurons. We suggest that Imp-L2 acts as a licensing factor for neuronal IIS activation through Dilp-2 to further increase the precision of insulin activity in the brain.

Particle physics experiments 1984

International Nuclear Information System (INIS)

Stuart, G.

1985-01-01

The Rutherford Appleton laboratory report describes work carried out in 1984 on experiments approved by the Particle Physics selection panel. The contents consist of unedited contributions from each experiment. (author)

Royal Decree No. 1116/1984 dated 9th May 1984, in respect of restoration of land affected by opencast mining operations. [Spain

Energy Technology Data Exchange (ETDEWEB)

1984-01-01

Of the set of norms relating to protection of the environment, which have come into force in Spain within the last few years, Royal Decree No. 1116/1984 of 9th May, 1984, and the Order from the Ministry of Industry and Energy dated 13th June 1984, which is complementary to it, are worth special mention in the field of mining. They both cover the restoration of open spaces affected by opencast mining operations.

Medical status of Marshallese accidentally exposed to 1954 Bravo fallout radiation, January 1983-December 1984

International Nuclear Information System (INIS)

Adams, W.H.; Engle, J.R.; Harper, J.A.; Heotis, P.M.; Scott, W.A.

1986-01-01

March 1, 1984, was the 30th anniversary of the Bravo thermonuclear test that resulted in the accidental exposure of the populations of Rongelap and Utirik atolls to radioactive fallout. The chronicling of the medical events resulting from that exposure is continued in this report, which covers the period from January 1983 through December 1984. An updated listing of all relevant publications from the Medical Department Brookhaven National Laboratory, is presented in the Reference Section. Thirty years of observation continue to show no detectable increase in mortality in the exposed population as a result of that exposure. The survival curves of the high-exposure Rongelap group, the low-exposure Utirik population, and an unexposed group of Rongelap people matched by age and sex to the exposed Rongelap group in 1957 continue to be similar. 89 refs., 2 figs., 6 tabs

Medical status of Marshallese accidentally exposed to 1954 Bravo fallout radiation, January 1983-December 1984

Energy Technology Data Exchange (ETDEWEB)

Adams, W.H.; Engle, J.R.; Harper, J.A.; Heotis, P.M.; Scott, W.A.

1986-01-01

March 1, 1984, was the 30th anniversary of the Bravo thermonuclear test that resulted in the accidental exposure of the populations of Rongelap and Utirik atolls to radioactive fallout. The chronicling of the medical events resulting from that exposure is continued in this report, which covers the period from January 1983 through December 1984. An updated listing of all relevant publications from the Medical Department Brookhaven National Laboratory, is presented in the Reference Section. Thirty years of observation continue to show no detectable increase in mortality in the exposed population as a result of that exposure. The survival curves of the high-exposure Rongelap group, the low-exposure Utirik population, and an unexposed group of Rongelap people matched by age and sex to the exposed Rongelap group in 1957 continue to be similar. 89 refs., 2 figs., 6 tabs.

1984 annual report

International Nuclear Information System (INIS)

1985-04-01

Ontario Hydro supplied 122.9 billion kilowatt-hours of electricity in 1984 to meet provincial and export demands. Total primary energy demand was 112.3 billion kWh, an increase of 5.9 percent. The year's peak demand of 18.9 kW occurred on January 12. In 1984 nuclear generating stations produced 40.4 billion kWh, 32.8 percent of the total energy supplied by Ontario Hydro. The additional output of two new nuclear units, Pickering-6 and Bruce-6, more than offset the loss of production caused by Pickering units 1 and 2 being out of service all year for retubing. In May, Atomic Energy of Canada Ltd. removed its Douglas Point nuclear station from service since it was no longer economic to operate the station. Nuclear plants produced electricity at an average cost of 2.2 cents per kWh, compared to 3.4 cents for fossil-fuelled plants

The quantitative regional cerebral blood flow measurement with autoradiography method using 123I-IMP SPECT. Evaluation of arterialized venous blood sampling as a substitute for arterial blood sampling

International Nuclear Information System (INIS)

Ohnishi, Takashi; Yano, Takao; Nakano, Shinichi; Jinnouchi, Seishi; Nagamachi, Shigeki; Flores, L. II; Nakahara, Hiroshi; Watanabe, Katsushi.

1996-01-01

The purpose of this study is validation of calibrating a standard input function in autoradiography (ARG) method by one point venous blood sampling as a substitute for that by one point arterial blood sampling. Ten and 20 minutes after intravenous constant infusion of 123 I-IMP, arterialized venous blood sampling from a dorsal vein were performed on 15 patients having ischemic cerebrovascular disease. And arterial blood sampling from radial artery was performed 10 min after 123 I-IMP infusion. The mean difference rates of integrated input function between calibrated standard input function by arterial blood sampling at 10 min and that by venous blood sampling were 4.1±3% and 9.3±5.4% at 10 and 20 min after 123 I-IMP infusion, respectively. The ratio of venous blood radioactivity to arterial blood radioactivity at 10 min after 123 I-IMP infusion was 0.96±0.02. There was an excellent correlation between ARG method CBF values obtained by arterial blood sampling at 10 min and those obtained by arterialized venous blood sampling at 10 min. In conclusion, a substitution by arterialized venous blood sampling from dorsal hand vein for artery can be possible. The optimized time for arterialized venous blood sampling was 10 min after 123 I-IMP infusion. (author)

Classical pathological variables recorded in the Danish Breast Cancer Cooperative Group's register 1978-2006

DEFF Research Database (Denmark)

Kiaer, Henrik W; Laenkholm, Anne-Vibeke; Nielsen, Bernt B

2008-01-01

>50mm from 7 to 4%. The distribution of the histological subtypes of malignant breast tumours has been almost unchanged. We found however a significant increase in the number of high grade tumours. A large increase in the number of removed axillary lymph nodes from 1989-2001 is related to improved......The Danish Breast Cancer Cooperative Group's register containing data from about 75 000 patients undergoing surgery for primary invasive breast cancer from 1978-2006 has been examined for classical pathological variables. During that period the diagnostic approach of malignant breast tumours...

Environmental monitoring at Hanford for 1984

International Nuclear Information System (INIS)

Price, K.R.; Carlile, J.M.V.; Dirkes, R.L.; Jaquish, R.E.; Trevathan, M.S.; Woodruff, R.K.

1985-05-01

Environmental surveillance activities performed by the Pacific Northwest Laboratory for the Department of Energy's Hanford Site for 1984 are discussed in this report. Samples of environmental media were collected in support of the Hanford Environmental Monitoring Program to determine radionuclide concentrations in the Hanford environs. Radiological impacts in terms of radiation dose equivalents as a result of Hanford operations are also discussed. Gross beta radioactivity concentrations in airborne particulates at all sampling locations were lower in 1984 than during 1983 as a result of declining levels of worldwide fallout. Slightly higher levels of 85 Kr and 129 I were noted at several onsite and offsite locations. The sampling location in close proximity to the PUREX plant also detected increased 3 H. Very low levels of radionuclides were detected in samples of Columbia River water during 1984. An extensive groundwater monitoring program was performed for the Hanford Site during 1984. The 3 H and nitrate plumes continued to move slowly toward the Columbia River. All 3 H results were within applicable concentration guides. Samples of deer, rabbits, game birds, waterfowl and fish were collected onsite or in the Columbia River at locations where the potential for radionuclide uptake was most likely, or at the nearest locations where wildlife samples were available. Radioisotope levels were measured. Dose rates from external penetrating radiation measured in the vicinity of residential areas were similar to those observed in the previous years, and no contribution from Hanford activities could be identified. An assessment of the 1984 potential radiological impacts attributable to the Hanford operations indicated that measured and calculated radiation doses to the public continued to be low, and well below applicable regulatory limits. 21 refs., 48 figs., 83 tabs

National Energy Balance - 1984

International Nuclear Information System (INIS)

Anon.

1984-01-01

The National Energy Balance - 1984 shows energy fluxes of several primary and secondary energy sources, since the productions to final consumption in the main economic sectors, since 1973 to 1983. (E.G.) [pt

CSIR Annual report 1984

CSIR Research Space (South Africa)

CSIR

1984-01-01

Full Text Available This report provides highlights on the activities and achievements of CSIR in the year 1984. An outline of the CSIR structure and financial reports are also presented in the report....

New design of N-isopropyl-p-[123I]iodoamphetamine (123I-IMP) lung imaging in the patient with lung cancer

International Nuclear Information System (INIS)

Tanaka, Eiko; Mishima, Michiaki; Kawakami, Kenzo; Sakai, Naoki; Sugiura, Naoharu; Ohi, Motoharu; Kuno, Kenshi; Taniguchi, Takashi; Itoh, Harumi.

1995-01-01

N-isopropyl-p-[ 123 I]iodoamphetamine ( 123 I-IMP) was injected intravenously into primary non small cell lung carcinoma patients (n=17). The average pixel count ratios of the cancerous area to the whole lung was measured in the initial and delayed images. In the initial image, this ratio was less than 1.0 for the entire group of patients, and was thought to reflect decreased blood flow in the cancerous tissues. The rate of counts within a ROI in the delayed image to counts in the same ROI in the initial image was also calculated and called the remain rate. The remain rate (delayed count/initial count) was significantly higher in the cancerous area than in the whole lung (0.65±0.30, median 0.62, 0.38±0.05, median 0.38, p<0.01). This observation was thought to be due to a relative decrease in the blood flow and the accumulation of IMP, which forms pools within the alveolar spaces of the cancerous areas. The image prepared with the remain rate revealed a hot image in the cancerous regions, even when this was not apparent in the delayed image. The remain rate image may therefore be useful in the identification of cancerous areas in lung tissue if it is used in comparison with the initial image. (author)

6. Seminar of the IIE-ININ-IMP on technological specialties. Topic 15: commercialization and technology transfer

International Nuclear Information System (INIS)

1992-01-01

The document includes 9 papers presented at the 6. Seminar of the IIE-ININ-IMP (Mexico) on technological specialties in the field of commercialization and technology transfer. (Topic 15). One item was in INIS s ubject scope and a separate abstract was prepared for it

Overexpression of the OsIMP Gene Increases the Accumulation of Inositol and Confers Enhanced Cold Tolerance in Tobacco through Modulation of the Antioxidant Enzymes’ Activities

Directory of Open Access Journals (Sweden)

Rong-Xiang Zhang

2017-07-01

Full Text Available Inositol is a cyclic polyol that is involved in various physiological processes, including signal transduction and stress adaptation in plants. l-myo-inositol monophosphatase (IMPase is one of the metal-dependent phosphatase family members and catalyzes the last reaction step of biosynthesis of inositol. Although increased IMPase activity induced by abiotic stress has been reported in chickpea plants, the role and regulation of the IMP gene in rice (Oryza sativa L. remains poorly understood. In the present work, we obtained a full-length cDNA sequence coding IMPase in the cold tolerant rice landraces in Gaogonggui, which is named as OsIMP. Multiple alignment results have displayed that this sequence has characteristic signature motifs and conserved enzyme active sites of the phosphatase super family. Phylogenetic analysis showed that IMPase is most closely related to that of the wild rice Oryza brachyantha, while transcript analysis revealed that the expression of the OsIMP is significantly induced by cold stress and exogenous abscisic acid (ABA treatment. Meanwhile, we cloned the 5’ flanking promoter sequence of the OsIMP gene and identified several important cis-acting elements, such as LTR (low-temperature responsiveness, TCA-element (salicylic acid responsiveness, ABRE-element (abscisic acid responsiveness, GARE-motif (gibberellin responsive, MBS (MYB Binding Site and other cis-acting elements related to defense and stress responsiveness. To further investigate the potential function of the OsIMP gene, we generated transgenic tobacco plants overexpressing the OsIMP gene and the cold tolerance test indicated that these transgenic tobacco plants exhibit improved cold tolerance. Furthermore, transgenic tobacco plants have a lower level of hydrogen peroxide (H2O2 and malondialdehyde (MDA, and a higher content of total chlorophyll as well as increased antioxidant enzyme activities of superoxide dismutase (SOD, catalase (CAT and peroxidase (POD

Daresbury 1984/5

International Nuclear Information System (INIS)

1985-01-01

The 1984/85 annual report of the Daresbury Laboratory, United Kingdom, is presented. Attention is centred on the Synchrotron Radiation Source and its scientific programme, and the Nuclear Structure Facility and its experimental work. Theoretical work at Daresbury including computational science is described, as well as computing and electronics. (U.K.)

Progress report 1984

International Nuclear Information System (INIS)

1985-01-01

The document informs about the activities made by the Institute of Nuclear Affairs (Colombia) during 1984 for each one of the technical areas: Agriculture, Industrial Applications and Metallurgy, Biochemistry and Radiopharmacy, Process Development, Electronics, Solar Energy, Gamma Facility, Nuclear Physics, Hydrology, Raw Materials, Chemistry, Health Physics, Reactor, and Library and Publications

Eldorado's annual report, 1984

International Nuclear Information System (INIS)

1985-01-01

In 1984 Eldorado Nuclear Ltd. and its subsidiaries achieved record revenues of $208.1 million and had a net profit of $4.4 million. Canada has become the largest producer and exporter of uranium in the western world; Eldorado and three other Canadian companies rank among the eight largest suppliers in the world. Eldorado produced 2029 tonnes of uranium and processed 4399 tonnes in 1984. More of the mineral exploration budget is being directed towards the discovery of other metals and minerals. Uranium exploration is to focus on the delineation of prospective ore bodies close to the Rabbit Lake mill. During the year the Canada Development Investment Corporation, Eldorado's parent company, increased its efforts to find new owners for Eldorado in order to return ownership to the private sector

Non-matched images with 123I-IMP and 99mTc-bicisate single-photon emission tomography in the demonstration of focal hyperaemia during the subacute phase of an ischaemic stroke

International Nuclear Information System (INIS)

Tamgac, F.; Moretti, J.L.; Defer, G.; Weinmann, P.; Roussi, A.; Cesaro, P.

1994-01-01

Focal hyperaemia is a fairly common phenomenon in the subacute phase of an ischaemic stroke. This has rarely been reported with iodine-123 iodoamphetamine (IMP) and has never been identified using technetium-99m bicisate ( 99m Tc-ECD. In this report, we present the case of a patient suffering from a ledt cerebral posterior stroke. 123 I-IMP single-photon emission tomography (SPET) images showed a large area of significantly increased IMP activity located in the left occipital region whereas 99m Tc-bicisate SPET displayed hypoactivity in the same area. (orig.)

Enhancement of the infectivity of SARS-CoV in BALB/c mice by IMP dehydrogenase inhibitors, including ribavirin.

Science.gov (United States)

Barnard, Dale L; Day, Craig W; Bailey, Kevin; Heiner, Matthew; Montgomery, Robert; Lauridsen, Larry; Winslow, Scott; Hoopes, Justin; Li, Joseph K-K; Lee, Jongdae; Carson, Dennis A; Cottam, Howard B; Sidwell, Robert W

2006-08-01

Because of the conflicting data concerning the SARS-CoV inhibitory efficacy of ribavirin, an inosine monophosphate (IMP) dehydrogenase inhibitor, studies were done to evaluate the efficacy of ribavirin and other IMP dehydrogenase inhibitors (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide (EICAR), mizoribine, and mycophenolic acid) in preventing viral replication in the lungs of BALB/c mice, a replication model for severe acute respiratory syndrome (SARS) infections (Subbarao, K., McAuliffe, J., Vogel, L., Fahle, G., Fischer, S., Tatti, K., Packard, M., Shieh, W.J., Zaki, S., Murphy, B., 2004. Prior infection and passive transfer of neutralizing antibody prevent replication of severe acute respiratory syndrome coronavirus (SARS-CoV) in the respiratory tract of mice. J. Virol. 78, 3572-3577). Ribavirin given at 75 mg/kg 4 h prior to virus exposure and then given twice daily for 3 days beginning at day 0 was found to increase virus lung titers and extend the length of time that virus could be detected in the lungs of mice. Other IMP dehydrogenase inhibitors administered near maximum tolerated doses using the same dosing regimen as for ribavirin were found to slightly enhance virus replication in the lungs. In addition, ribavirin treatment seemed also to promote the production of pro-inflammatory cytokines 4 days after cessation of treatment, although after 3 days of treatment ribavirin inhibited pro-inflammatory cytokine production in infected mice, significantly reducing the levels of the cytokines IL-1alpha, interleukin-5 (IL-5), monocyte chemotactic protein-1 (MCP-1), and granulocyte-macrophage colony stimulating factor (GM-CSF). These findings suggest that ribavirin may actually contribute to the pathogenesis of SARS-CoV by prolonging and/or enhancing viral replication in the lungs. By not inhibiting viral replication in the lungs of infected mice, ribavirin treatment may have provided a continual source of stimulation for the inflammatory response

6. Seminar of the IIE-ININ-IMP on technological specialties. Topic 9: electronics, instrumentation and control

International Nuclear Information System (INIS)

1992-01-01

The document includes 10 papers presented at the 6. Seminar of the IIE-ININ-IMP on technological specialities in the field of electronics, instrumentation and control. (Topic 9). From these, 4 papers were in INIS subject scope and a separate abstract was prepared for each of them

6. Seminar of the IIE-ININ-IMP on technological specialties. Topic 14: systems and infomation services

International Nuclear Information System (INIS)

1992-01-01

The document includes 9 papers presented at the 6. Seminar of the IIE-ININ-IMP (Mexico) on technological specialties in the field of information systems and services. (Topic 14). Two items were in INIS subject scope and a separate abstract was prepared for each of them

Annual Report 1984

International Nuclear Information System (INIS)

1984-01-01

This report presents an account of the activities carried out at the SCK/CEN, Mol, during the year 1984. It deals with light water reactors, fast neutron reactors, fuel cycle, fusion, oriented basic research, non-nuclear programmes, the BR-2 materials testing reactor and its associated facilities and supporting activities and services. (AF)

Annual report 1984

International Nuclear Information System (INIS)

1984-01-01

After receiving a grant of 5.8 million dollars for an energy compressor system, a pulse stretcher ring and a new magnetic spectrometer, the Saskatchewan Accelerator Laboratory devoted itself mainly to an upgrading program in 1984. This report describes the project as well as the physics carried out to maintain contact with experiments

Environmental and Occupational Safety Division annual progress report for 1984

International Nuclear Information System (INIS)

1985-11-01

Over 950 radiation workers were monitored at ORNL for both internal and external exposure to ionizing radiation and radioactive materials in 1984, and no employee exceeded 50% of the applicable DOE dose limit. No internal exposure exceeded 10% of the maximum permissible organ burden, as determined by in-vivo gamma spectrometry. Dose readings from 5000 TLDs and 136,000 pocket meters were determined, and more than 5800 calibrations were performed on these devices. Approximately 82,000 radioassays were performed; among these were 1500 urinalyses and 3000 radiochemical analyses. Over 3000 calibrations were performed for approximately 2000 portable and fixed survey instruments. Response teams were identified in support of the Radiological Assistance Program (RAP). Documentation, procedures, and equipment for the RAP vehicle were upgraded. A long-range environmental plan was issued early in the year and again in June 1984 to document the scope and justification for each project. The DEM is developing an environmental information system for managing DOE-ORO and ORNL environmental data. Five hundred eighty-four waste disposal requests containing 5769 items were handled by the Hazardous Materials Control Group during 1984. The Office of Operational Safety made significant progress in the completion of Safety Analysis Reports for existing facilities. The Radiation and Safety Surveys Department is becoming increasingly involved in work resulting in facility improvement, repair, or upgrade as well as decontamination and decommissioning of older facilities

Report of results and progress research (1982-1984) total research on long life radioactive waste management

International Nuclear Information System (INIS)

1985-03-01

The specific research ''Synthetic research on long life radioactive waste management'' has been advanced in the Research Center for Nuclear Energy, University of Tokyo, for three years since 1982. This research was roughly divided into material science, biology and process engineering, and the research has been advanced according to 14 subthemes by the cooperation of the researchers in wide fields in the university. In this report, the report of the progress of research and the data on the results of researche from fiscal year 1982 to 1984 are summarized. The title of research, organization, the persons in charge, the period of research, the title of report, the objective, contents, state of progress, results obtained in 1984 and results obtained during three years of 5 material group papers, 7 process group papers and 4 biology group papers are given. (Kako, I.)

Impôts en France : réunion publique le mercredi 19 mars 2014

CERN Multimedia

CERN. Geneva

2014-01-01

Impôts en France : réunion publique le mercredi 19 mars 2014 Une réunion publique aura lieu le mercredi 19 mars de 13h à 15h dans l’amphithéâtre principal (500/1-001). Au cours de cette réunion, MM. Jean-Louis Brandolin et Gérard Polizzi, respectivement responsable et responsable-adjoint du Service des impôts des particuliers et des entreprises de Bellegarde, Centre des finances publiques, apporteront leur expertise au sujet de l’imposition des membres du personnel du CERN domiciliés en France. Seront à l’ordre du jour les questions de principe que se posent apparemment de nombreux membres du personnel : par exemple, la définition du domicile fiscal, le contenu de la déclaration de revenus (mention des revenus CERN et déclaration des autres revenus de sources française ou étrangère), la déclaration des comptes bancaires à l’étranger, l’assujettissement (dans certaines conditions) à la CSG-CRDS. Cette réunion publique portera UNIQUEMENT sur des questions de principe ...

Individual or group antenatal education for childbirth or parenthood, or both.

Science.gov (United States)

Gagnon, A J; Sandall, J

2007-07-18

Structured antenatal education programs for childbirth or parenthood, or both, are commonly recommended for pregnant women and their partners by healthcare professionals in many parts of the world. Such programs are usually offered to groups but may be offered to individuals. To assess the effects of this education on knowledge acquisition, anxiety, sense of control, pain, labour and birth support, breastfeeding, infant-care abilities, and psychological and social adjustment. We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (April 2006), CINAHL (1982 to April 2006), ERIC (1984 to April 2006), EMBASE (1980 to April 2006) and PsycINFO (1988 to April 2006). We handsearched the Journal of Psychosomatic Research from 1956 to April 2006 and reviewed the reference lists of retrieved studies. Randomized controlled trials of any structured educational program provided during pregnancy by an educator to either parent that included information related to pregnancy, birth or parenthood. The educational interventions could have been provided on an individual or group basis. Educational interventions directed exclusively to either increasing breastfeeding success, knowledge of and coping skills concerning postpartum depression, improving maternal psycho-social health including anxiety, depression and self-esteem or reducing smoking were excluded. Both authors assessed trial quality and extracted data from published reports. Nine trials, involving 2284 women, were included. Thirty-seven studies were excluded. Educational interventions were the focus of eight of the studies (combined n = 1009). Details of the randomization procedure, allocation concealment, and/or participant accrual or loss for these trials were not reported. No consistent results were found. Sample sizes were very small to moderate, ranging from 10 to 318. No data were reported concerning anxiety, breastfeeding success, or general social support. Knowledge acquisition, sense of control

Evaluation of cerebral perfusion in patients with neuropsychiatric systemic lupus erythematosus using 123I-IMP SPECT

International Nuclear Information System (INIS)

Yoshida, Atsuko; Shishido, Fumio; Kato, Kazuo; Watanabe, Hiroshi; Seino, Osamu

2007-01-01

In the course of systemic lupus erythematosus (SLE), central nervous system (CNS) complications occur at a high frequency. An accurate diagnosis of CNS lupus, differentiated from secondary CNS involvement, is difficult. CNS lupus is indicative of advancing primary disease and is treated by steroid pulse therapy or increased dosage of steroids. In contrast, if symptoms are caused by secondary CNS complications, it is possible to observe or treat these complications using symptomatic therapy. We examined whether quantitative cerebral blood flow (CBF) measured using cerebral perfusion single photon emission computed tomography (SPECT) can be used to differentiate CNS lupus from secondary CNS involvement. We divided 18 SLE patients with CNS symptoms into a CNS lupus group and a non-CNS lupus group, and then compared the mean cerebral blood flow (mCBF) of each group of patients. SPECT was performed with N-isopropyl-p-[ 123 I] iodoamphetamine (IMP), with quantitation carried out by table look-up and autoradiographic methods. The mCBF of both groups was decreased; however, the mCBF of patients with CNS lupus was significantly lower than that of non-CNS lupus patients. Quantitative CBF may provide a useful tool to distinguish CNS lupus from non-CNS lupus. (author)

6. Seminar of the IIE-ININ-IMP on technological specialties. Topic 11: standards and quality assurance

International Nuclear Information System (INIS)

1992-01-01

The document includes 8 papers presented at the 6. Seminar of the IIE-ININ-IMP (Mexico) on technological specialties in the field of standards and quality assurance. (Topic 11). From these, 2 papers were in INIS subject scope and a separate abstract was prepared for each of them

3. quarter 2006 sales revenue; Chiffres d'affaires du 3. trimestre 2006

Energy Technology Data Exchange (ETDEWEB)

NONE

2006-10-15

This document presents the sales revenue of the 3. quarter 2006 for the Group AREVA. The sales revenues for the first nine months of 2006 are up by 8,1% to 7,556 millions euros; the nuclear operations are up by 5,2% reflecting strong performance in the front end division; the transmission and distribution division is up by 14%. (A.L.B.)

Comparison of Tc-99m HM-PAO and I-123 IMP cerebral SPECT images in Alzheimer's disease and multi-infarct dementia

Energy Technology Data Exchange (ETDEWEB)

Gemmell, H G; Sharp, P F; Besson, J A.O.; Ebmeier, K P; Smith, F W

1988-10-01

SPECT images of the brain can be obtained using either /sup 123/I labelled amines or /sup 99m/Tc-hexamethylpropyleneamineoxime (HM-PAO). Both materials produce images which are blood flow dominated and so appear similar in normal subjects, although the respective mechanisms of uptake are not yet finally established. It seems likely, however, that the different mechanisms of uptake are responsible for recent reports of some differences seen in images obtained with the two types of agent in patients with cerebral pathology, mainly cerebrovascular disease. In this study, 12 demented patients, 6 with dementia of the Alzheimer type (DAT) and 6 with multi infarct dementia (MID), were imaged with /sup 123/I-isopropylamphetamine (IMP) and /sup 99m/Tc-HM-PAO and the images compared. Significantly more lesions were seen with IMP than HM-PAO (P < 0.02); out of a possible 120 sites, 41 lesions were seen with IMP compared to 28 with HM-PAO, 23 being seen with both agents. However, it is concluded that either agent can be used for the differential diagnosis of dementia, a task for which the new cerebral blood flow agents seem well suited.

Annual report 1984-85

International Nuclear Information System (INIS)

1985-01-01

The annual report for Atomic Energy of Canada Limited is presented. An overview of the last year's major events is given and some new areas of expansion are outlined. Financial data for the fiscal year 1984/85 is also given

Slovensky plynarensky priemysel. Annual report 2006

International Nuclear Information System (INIS)

2007-01-01

This Annual Report contains the review of the results of the joint stock company Slovensky plynarensky priemysel (SPP - Slovak Gas Industry) and subsidiary corporations in relation to the year 2006. This report contains the following headings: I. SPP a. s.: (1) Statement by the Chairman of the Board of Directors; (2) Statement by the General Director; (3) SPP a. s. Board of Directors as at 31. 12. 2006; (3) SPP a. s. Top Executive Management as at 31. 12. 2006; (4) SPP a. s. Supervisory Board as at 31. 12. 2006; (5) SPP a. s. - Company Profile; (6) Organisational Structure of SPP a. s. applicable as of 31. 12. 2006; (7) Economic and Financial Performance; (8) Capital Structure; (9) Natural Gas Trade; (10) Equity Holdings; (11) Summary results of SPP a. s. and Independent Auditor's Report; (12) SPP a. s. - Contact. II. SPP - distribucia a. s.: (1)Statement by the Chairman of the Board of Directors of SPP - distribucia a. s.; (2) Statement by the General Director of SPP - distribucia a. s.; (3) Establishment of the company SPP - distribucia a. s.; (4) SPP - distribucia a. s. Board of Directors as at 31. 12. 2006; (5) SPP - distribucia a. s. Supervisory Board as at 31. 12. 2006; (6) Organisational structure of SPP- distribucia a. s. applicable as of 31. 12. 2006; (7) Natural Gas Distribution; (8) SPP - distribucia a. s. - Contact. III. SPP - preprava a. s.: (1) Statement by the Chairman of the Board of Directors of SPP - preprava a. s.; (2) Statement by the General Director of SPP - preprava a. s.; (3) Establishment of the company SPP - preprava a. s.; (4) SPP - preprava a. s. Board of Directors as at 31. 12. 2006; (5) SPP - preprava a. s. Supervisory Board as at 31. 12. 2006; (6) Organisational structure of SPP - preprava a. s applicable as of 31. 12. 2006; (7) Natural Gas Transmission; (8) SPP - preprava a. s. - Contact. IV. SPP Core Group: (1) Vision, Mission; (2) Code of Conduct and the Company's Core Values; (3) Human Resources; (4) Safety and Environmental

Slovensky plynarensky priemysel. Annual report 2006

International Nuclear Information System (INIS)

2007-01-01

This Annual Report contains the review of the results of the joint stock company Slovensky plynarensky priemysel (SPP - Slovak Gas Industry) and subsidiary corporations in relation to the year 2006. This report contains the following headings: I. SPP a. s.: (1) Statement by the Chairman of the Board of Directors; (2) Statement by the General Director; (3) SPP a. s. Board of Directors as at 31. 12. 2006; (3) SPP a. s. Top Executive Management as at 31. 12. 2006; (4) SPP a. s. Supervisory Board as at 31. 12. 2006; (5) SPP a. s. - Company Profile; (6) Organisational Structure of SPP a. s. applicable as of 31. 12. 2006; (7) Economic and Financial Performance; (8) Capital Structure; (9) Natural Gas Trade; (10) Equity Holdings; (11) Summary results of SPP a. s. and Independent Auditor's Report; (12) SPP a. s. - Contact. II. SPP - distribucia a. s.: (1) Statement by the Chairman of the Board of Directors of SPP - distribucia a. s.; (2) Statement by the General Director of SPP - distribucia a. s.; (3) Establishment of the company SPP - distribucia a. s.; (4) SPP - distribucia a. s. Board of Directors as at 31. 12. 2006; (5) SPP - distribucia a. s. Supervisory Board as at 31. 12. 2006; (6) Organisational structure of SPP- distribucia a. s. applicable as of 31. 12. 2006; (7) Natural Gas Distribution; (8) SPP - distribucia a. s. - Contact. III. SPP - preprava a. s.: (1) Statement by the Chairman of the Board of Directors of SPP - preprava a. s.; (2) Statement by the General Director of SPP - preprava a. s.; (3) Establishment of the company SPP - preprava a. s.; (4) SPP - preprava a. s. Board of Directors as at 31. 12. 2006; (5) SPP - preprava a. s. Supervisory Board as at 31. 12. 2006; (6) Organisational structure of SPP - preprava a. s applicable as of 31. 12. 2006; (7) Natural Gas Transmission; (8) SPP - preprava a. s. - Contact. IV. SPP Core Group: (1) Vision, Mission; (2) Code of Conduct and the Company's Core Values; (3) Human Resources; (4) Safety and Environmental

1984. Annual progress report of the Institut de Physique Nucleaire at Orsay

International Nuclear Information System (INIS)

1985-01-01

The first part of this report presents the work of the year 1984 of research in the Division of experimental physics of the Institute of Nuclear Physics in Orsay, the activities are conducted in six axes: nuclear structure, high excitation energy nuclear states, heavy ion collision phenomena, intermediate energy nuclear physics, radiochemistry and perinuclear research. The second part presents the studies of the theoretical physics division of the Institute for Nuclear Physics in Orsay in 1984. The different research axes are the following: nuclear physics, intermediate energy nuclear physics, elementary particles. The third part presents a compilation of the work done by the technical groups of the laboratory. The different axes are: operation and development of accelerators, design studies on new superconducting cyclotron project equipment and instrumental projects, technical developments used for specific research [fr

Areva half-year report june 30, 2006; Areva rapport semestriel 30 juin 2006

Energy Technology Data Exchange (ETDEWEB)

NONE

2006-07-01

This document is the half-year financial report of the Areva group for 2006. It presents: 1 - Highlights of the period; 2 - Key data: Summary data, Segment reporting, Backlog, Income statement, Review by business division, Cash flow, Balance sheet data; 3 - Outlook; 4 - Events subsequent to the half-year end; 5 - Consolidated financial statements: Statutory auditors' report on the interim consolidated financial statements for the period January 1, 2006 to June 30, 2006, Consolidated income statement, Consolidated balance sheet, Consolidated cash flow statement, Consolidated statement of changes in equity, Segment reporting, Notes to the consolidated financial statements.

Areva half-year report june 30, 2006; Areva rapport semestriel 30 juin 2006

Energy Technology Data Exchange (ETDEWEB)

NONE

2006-07-01

This document is the half-year financial report of the Areva group for 2006. It presents: 1 - Highlights of the period; 2 - Key data: Summary data, Segment reporting, Backlog, Income statement, Review by business division, Cash flow, Balance sheet data; 3 - Outlook; 4 - Events subsequent to the half-year end; 5 - Consolidated financial statements: Statutory auditors' report on the interim consolidated financial statements for the period January 1, 2006 to June 30, 2006, Consolidated income statement, Consolidated balance sheet, Consolidated cash flow statement, Consolidated statement of changes in equity, Segment reporting, Notes to the consolidated financial statements.

Santos e devotos no império ultramarino português

Directory of Open Access Journals (Sweden)

Beatriz Catão Cruz Santos

2009-01-01

Full Text Available O artigo faz uma história da coleção de vilancicos de São Gonçalo de Amarante, que integram a Coleção Barbosa Machado na Biblioteca Nacional do Rio de Janeiro e, simultaneamente, apresenta reflexões sobre a relação santo-devoto no Império Ultramarino Português no século XVIII. Os vilancicos são identificados como um gênero retórico poético que evoca o santo e uma prática religiosa que contrastava com outras. Parte-se de uma perspectiva comparativa entre os vilancicos e outras evidências sobre a relação santo-devoto e, em particular, sobre o santo e sua festa na sociedade colonial escravista. O artigo dialoga com a historiografia centrada na noção de Império e com uma bibliografia da História e das Ciências Sociais voltada para a relação santodevoto, a santidade e as festas.The paper produces a story of vilancicos for Saint Gonçalo do Amarante, that are part of the Rio de Janeiro National Library Barbosa Machado Collection and presents reflections on the relation saint-devotees in the Portuguese Overseas Empire during the 18th century. The vilancicos are identified as a rhetoric poetic genre that reminds the saint and a religious practice that contrasted with others. It starts from a comparative perspective between the vilancicos and other evidences about the relation saint-devotee, and in particular, about the saint and his feast in a colonial and proslavery society. The article deals with the historiography centered in the notion of Empire, and with a bibliography of History and Social Sciences pointed to the relation saint-devotee, the holiness and the feasts.

US Nuclear Regulatory Commission, 1984 annual report. Volume 1

International Nuclear Information System (INIS)

1985-01-01

This is the 10th annual report of the US Nuclear Regulatory Commission (NRC). This report covers the major activities, events, decisions and planning that took place during fiscal year 1984 (October 1983 through September 1984) within the NRC or involving the NRC. Information is presented concerning 1984 highlights and planning for 1985; reactor regulation; cleanup at Three Mile Island Unit 2; operational experience; nuclear materials; safeguards; waste management; inspection, enforcement, quality assurance, and emergency preparedness; cooperation with the States; international programs; nuclear regulatory research; proceedings and litigation; and management and communication

6. Seminar of the IIE-ININ-IMP on technological specialties. Topic 10: industrial applications of radiation and control

International Nuclear Information System (INIS)

1992-01-01

The document includes 7 papers presented at the 6. Seminar of the IIE-ININ-IMP (Mexico) on technological specialties in the field of industrial applications of radiation and control. (Topic 10). A separate abstract was prepared for each paper

Nobel 1984

International Nuclear Information System (INIS)

Anon.

1984-01-01

There was general jubilation at CERN following the announcement from Stockholm on 17 October that Carlo Rubbia and Simon van der Meer had been nominated for the 1984 Nobel Prize for physics by the Royal Swedish Academy of Sciences 'for their decisive contributions to the large project which led to the discovery of the field particles W and Z, communicators of the weak interaction'. These discoveries, made last year at CERN, rank among the greatest achievements in the history of science

A technique for a rapid imaging of regional CBF and partition coefficient using dynamic SPECT and N-isopropyl-p-[123I]iodoamphetamine (123I-IMP)

International Nuclear Information System (INIS)

Itoh, Hiroshi; Iida, Hidehiro; Murakami, Matsutaro

1993-01-01

IMP (iodoamphetamine) is a flow tracer due to a large first pass extraction fraction and high affinity in the brain, but significant clearance from the brain causes change of distribution when the beginning time of scan is delayed. The purpose of the present study was to develop a new method to rapidly calculate a quantitative cerebral blood flow (CBF) image by taking clearance effects into account. A dynamic SPECT scan was performed on 5 subjects (4 patients with cerebral infarction and one normal volunteer) following slow intravenous infusion of 123 I-IMP. The arterial input function was obtained by frequent blood sampling and by measuring an octanol extraction ratio for each sample. Firstly, non-linear least square fitting (NLS) was performed to investigate the tracer kinetics of 123 I-IMP. The 3 compartment model analysis yielded negligibly small k 3 (retaining rate constant) (0.0056±0.0128 (ml/ml/min)), and consistent k 1 (transport rate constant) with those determined by 2 compartment model (2CM) analysis (r=0.96, p 1 was consistent with CBF measured by 15 O water PET technique. These observations suggested the validity of using 2CM for describing the IMP tracer kinetics. Secondly, a weighted integration (WI) technique has been implemented to calculate rapidly images of CBF and partition coefficient (V d ). The WI technique yielded values of CBF (k 1 ) and V d (k 1 /k 2 ). They were confirmed to be consistent with those determined by NLS technique (CBF; r=0.99, p d ; r=0.99, p 1 agreed well with PET CBF (r=0.91, p d in infarcted patients. This supports an importance for calculating V d image. V d image will provide additional clinical information because 123 I-IMP binding mechanism may be related to cell viability. (author)

Medical physics, 1984

International Nuclear Information System (INIS)

Schmidt, T.

1985-01-01

The papers presented at the 15th Scientific Conference of the Deutsche Gesellschaft fuer Medizinische Physik, held from September 27-28, 1984 in Nuernberg, F.R.G., give an account of the advances made with regard to quality control and management and to radiological safety problems and requirements in the fields of radiological and nuclear medical diagnostics and radiotherapy. (WU) [de

Strontium-90 and cesium-137 in freshwater fish (from Jul. 1984 to Dec. 1984)

International Nuclear Information System (INIS)

1984-01-01

Sr-90 and Cs-137 in freshwater fish were determined using radiochemical analysis. Three species of fish (Cyprinus carpio, Carassius auratus, and Hypomesus transpacificus nipponensis) were collected during the fishing season from eight sampling locations. Only the edible part was used in case of larger sized fish, and the whole part was used in case of smaller ones. Each sample was weighed and placed in a stainless steel pan or a porcelain dish. After carbonized, the sample was ashed in an electric muffle furnace. The maximum value of Sr-90 was 96 +- 1.7 pCi/kg in Cyprinus carpio collected from Akita in July 1984; and that of Cs-137 was 11 +- 0.7 pCi/kg in Carassius auratus from Fukui in December 1984. (Namekawa, K.)

Status of safety at Areva group facilities. 2006 annual report; Etat de surete des installations nucleaires. Rapport annuel 2006

Energy Technology Data Exchange (ETDEWEB)

NONE

2006-07-01

This report presents a snapshot of nuclear safety and radiation protection conditions in the AREVA group's nuclear installations in France and abroad, as well as of radiation protection aspects in service activities, as identified over the course of the annual inspections and analyses program carried out by the General Inspectorate in 2006. This report is presented to the AREVA Supervisory Board, communicated to the labor representation bodies concerned, and made public. In light of the inspections, appraisals and coordination missions it has performed, the General Inspectorate considers that the nuclear safety level of the AREVA group's nuclear installations is satisfactory. It particularly noted positive changes on numerous sites and efforts in the field of continuous improvement that have helped to strengthen nuclear safety. This has been possible through the full involvement of management teams, an improvement effort initiated by upper management, actions to increase personnel awareness of nuclear safety culture, and supervisors' heightened presence around operators. However, the occurrence of certain events in facilities has led us to question the nuclear safety repercussions that the changes to activities or organization on some sites have had. In these times of change, drifts in nuclear safety culture have been identified. The General Inspectorate considers that a preliminary analysis of the human and organizational factors of these changes, sized to match the impact the change has on nuclear safety, should be made to ensure that a guaranteed level of nuclear safety is maintained (allowance for changes to references, availability of the necessary skills, resources of the operating and support structures, etc.). Preparations should also be made to monitor the changes and spot any telltale signs of drift in the application phase. Managers should be extra vigilant and the occurrence of any drift should be systematically dealt with ahead of

2006 Annual Operations Report for INTEC Operable Unit 3-13, Group 1, Tank Farm Interim Action

International Nuclear Information System (INIS)

D. E. Shanklin

2007-01-01

This annual operations report describes the requirements followed and activities conducted to inspect, monitor, and maintain the items installed during performance of the Waste Area Group 3, Operable Unit 3-13, Group 1, Tank Farm Interim Action, at the Idaho Nuclear Technology and Engineering Center. This report covers the time period from January 1 through December 31, 2006, and describes inspection and monitoring activities for the surface-sealed areas within the tank farm, concrete-lined ditches and culverts in and around the tank farm, the lift station, and the lined evaporation pond. These activities are intended to assure that the interim action is functioning adequately to meet the objectives stated in the Operable Unit 3-13, Record of Decision for the Group 1, Tank Farm Interim Action (DOE/ID-10660) as described in the Group 1 Remedial Design/Remedial Action Work Plan (DOE/ID-10772)

Design of the IMP microbeam irradiation system for 100 MeV/u heavy ions

International Nuclear Information System (INIS)

Sheng Lina; Song Mingtao; Zhang Xiaoqi; Yang Xiaotian; Gao Daqing; He Yuan; Zhang Bin; Liu Jie; Sun Youmei; Dang Bingrong; Lwenjian; Su Hong; Man Kaidi; Guo Yizhen; Wang Zhiguang; Zhan Wenlong

2009-01-01

A state-of-the-art high energy heavy ion microbeam irradiation system is constructed at the Institute of Modern Physics of the Chinese Academy of Sciences. This microbeam system operates in both full current intensity mode and single ion mode. It delivers a predefined number of ions to pre-selected targets for research in biology and material science. The characteristic of this microbeam system is high energy and vertical irradiation. A quadrupole focusing system, in combination with a series of slits, has been designed to optimize the spatial resolution. A symmetrically achromatic system leads the beam downwards and serves simultaneously as an energy analyzer. A high gradient quadrupole triplet finally focuses a C 6+ ion beam to 1 μm in the vacuum chamber within the energy range from 10 MeV/u to 100 MeV/u. In this paper, the IMP microbeam system is described in detail. A systematic investigation of the ion beam optics of this microbeam system is presented together with the associated aberrations. Comparison is made between the IMP microbeam system and the other existing systems to further discuss the performance of this microbeam. Then the optimized initial beam parameters are given for high resolution and high hitting efficiency. At last, the experiment platform is briefly introduced. (authors)

Effects of scatter correction on regional distribution of cerebral blood flow using I-123-IMP and SPECT

International Nuclear Information System (INIS)

Ito, Hiroshi; Iida, Hidehiro; Kinoshita, Toshibumi; Hatazawa, Jun; Okudera, Toshio; Uemura, Kazuo

1999-01-01

The transmission dependent convolution subtraction method which is one of the methods for scatter correction of SPECT was applied to the assessment of CBF using SPECT and I-123-IMP. The effects of scatter correction on regional distribution of CBF were evaluated on a pixel by pixel basis by means of an anatomic standardization technique. SPECT scan was performed on six healthy men. Image reconstruction was carried out with and without the scatter correction. All reconstructed images were globally normalized for the radioactivity of each pixel, and transformed into a standard brain anatomy. After anatomic standardization, the average SPECT images were calculated for scatter corrected and uncorrected groups, and these groups were compared on pixel by pixel basis. In the scatter uncorrected group, a significant overestimation of CBF was observed in the deep cerebral white matter, pons, thalamus, putamen, hippocampal region and cingulate gyrus as compared with scatter corrected group. A significant underestimation was observed in all neocortical regions, especially in the occipital and parietal lobes, and the cerebellar cortex. The regional distribution of CBF obtained by scatter corrected SPECT was similar to that obtained by O-15 water PET. The scatter correction is needed for the assessment of CBF using SPECT. (author)

Clinical evaluation of Parkinson's disease using sup 123 I-IMP SPECT

Energy Technology Data Exchange (ETDEWEB)

Hayashi, Hiroko; Odano, Ikuo; Nishihara, Mamiko; Higuchi, Shouichi; Sakai, Kunio [Niigata Univ. (Japan). School of Medicine; Ishikawa, Atsushi

1989-11-01

N-isopropyl-p({sup 123}I)iodoamphetamine ({sup 123}I-IMP) SPECT and regional cerebral blood flow (rCBF) studies were performed in 20 patients with Parkinson's disease (PD) and 8 normal subjects. RCBF was measured by the arterial blood sampling method which used the microsphere model. We analized seven factors which might be related to the rCBF in PD, i.e., age, stage, duration of the disease, cerebral atrophy, severity of dementia, laterality of symptoms and motor disability score (MDS; the degree of akinesia, rigidity, tremor, gait disturbance, freezing and pulsion sign). Compared with normal subjects, global CBF (supratentorial mean rCBF) was reduced by 21.8% in PD. In particular, rCBF in the basal ganglia and that of frontal cortex were reduced by 25.3% and 24.8%, respectively. Distribution patterns of rCBF in PD were almost as same as those in normals except for cerebellum. The reduction of both rCBFs in the basal ganglia and parietal cortex significantly correlated with MDS (p<0.05, respectively). Especially, akinesia was closely correlated to the reduction of rCBF in the parietal cortex (p<0.02). Moreover, we observed a significant relationship between cerebral atrophy and reduction of rCBF in each region except for cerebellum. However, there was no significant correlation between the severity of dementia and reduction of rCBF, even in the frontal cortex or parietal cortex. These data show that the severity of dementia in PD may be connected with other factors except for rCBF. {sup 123}I-IMP SPECT study is a useful method for clinical evaluation of PD. (author).

Strong sales growth in 2006: + 21 per cent

International Nuclear Information System (INIS)

2007-01-01

Paris, February 14, 2007 - The Gaz de France group today reported record consolidated sales of euro 27,642 million in 2006, up 21 per cent compared with 2005. Under average weather conditions and comparable accounting methods, sales increased by 24 per cent versus 2005. This growth results primarily from an overall increase in European energy prices notwithstanding the slight decrease in prices towards the end of the year. The group also benefited from an increase in volumes and from the integration of new operations. After a colder first half of the year compared to that of the previous year, the autumn of 2006 was particularly warm. This had a negative impact on sales growth (there was a 12 billion kWh decrease between 2005 and 2006). The sales generated by the group's international activities increased by 33 per cent to a total of euro 10,839 m in 2006 and now account for almost 40 per cent of the group's overall sales. In this context, the group confirmed at the board meeting held on January 23, 2007 that it would reach the targets set for 2006, namely: - Growth in EBITDA above 20 per cent, e.g. in excess of euro 5 billion, - Net income of more than euro 2.2 billion

Strong sales growth in 2006: + 21 per cent

Energy Technology Data Exchange (ETDEWEB)

NONE

2007-07-01

Paris, February 14, 2007 - The Gaz de France group today reported record consolidated sales of euro 27,642 million in 2006, up 21 per cent compared with 2005. Under average weather conditions and comparable accounting methods, sales increased by 24 per cent versus 2005. This growth results primarily from an overall increase in European energy prices notwithstanding the slight decrease in prices towards the end of the year. The group also benefited from an increase in volumes and from the integration of new operations. After a colder first half of the year compared to that of the previous year, the autumn of 2006 was particularly warm. This had a negative impact on sales growth (there was a 12 billion kWh decrease between 2005 and 2006). The sales generated by the group's international activities increased by 33 per cent to a total of euro 10,839 m in 2006 and now account for almost 40 per cent of the group's overall sales. In this context, the group confirmed at the board meeting held on January 23, 2007 that it would reach the targets set for 2006, namely: - Growth in EBITDA above 20 per cent, e.g. in excess of euro 5 billion, - Net income of more than euro 2.2 billion.

Areva, reference document 2006; Areva, document de reference 2006

Energy Technology Data Exchange (ETDEWEB)

NONE

2006-07-01

This reference document contains information on the AREVA group's objectives, prospects and development strategies, particularly in Chapters 4 and 7. It contains information on the markets, market shares and competitive position of the AREVA group. Content: - 1 Person responsible for the reference document and persons responsible for auditing the financial statements; - 2 Information pertaining to the transaction (Not applicable); - 3 General information on the company and its share capital: Information on AREVA, on share capital and voting rights, Investment certificate trading, Dividends, Organization chart of AREVA group companies, Equity interests, Shareholders' agreements; - 4 Information on company operations, new developments and future prospects: Overview and strategy of the AREVA group, The Nuclear Power and Transmission and Distribution markets, The energy businesses of the AREVA group, Front End division, Reactors and Services division, Back End division, Transmission and Distribution division, Major contracts, The principal sites of the AREVA group, AREVA's customers and suppliers, Sustainable Development and Continuous Improvement, Capital spending programs, Research and development programs, intellectual property and trademarks, Risk and insurance; - 5 Assets - Financial position - Financial performance: Analysis of and comments on the group's financial position and performance, 2006 Human Resources Report, Environmental Report, Consolidated financial statements, Notes to the consolidated financial statements, AREVA SA financial statements, Notes to the corporate financial statements; 6 - Corporate Governance: Composition and functioning of corporate bodies, Executive compensation, Profit-sharing plans, AREVA Values Charter, Annual Combined General Meeting of Shareholders of May 3, 2007; 7 - Recent developments and future prospects: Events subsequent to year-end closing for 2006, Outlook; 8 - Glossary; 9 - Table of concordance.

IMP-8 observations of the spectra, composition, and variability of solar heavy ions at high energies relevant to manned space missions

International Nuclear Information System (INIS)

Tylka, Allan J.; Dietrich, William F.

1999-01-01

In more than 25 years of almost continuous observations, the University of Chicago's Cosmic Ray Telescope (CRT) on IMP-8 has amassed a unique database on high-energy solar heavy ions of potential relevance to manned spaceflight. In the very largest particle events, IMP-8/CRT has even observed solar Fe ions above the Galactic cosmic ray background up to ∼800 MeV/nucleon, an energy sufficiently high to penetrate nearly 25 g/cm 2 of shielding. IMP-8/CRT observations show that high-energy heavy-ion spectra are often surprisingly hard power laws, without the exponential roll-offs suggested by stochastic acceleration fits to lower energy measurements alone. Also, in many solar particle events the Fe/O ratio grows with increasing energy, contrary to the notion that ions with higher mass-to-charge ratios should be less abundant at higher energies. Previous studies of radiation hazards for manned spaceflight have often assumed heavy-ion composition and steeply-falling energy spectra inconsistent with these observations. Conclusions based on such studies should therefore be re-assessed. The significant event-to-event variability observed in the high-energy solar heavy ions also has important implications for strategies in building probabilistic models of solar particle radiation hazards

NEA activities in 1984

International Nuclear Information System (INIS)

1985-01-01

This report presents the main features of the Agency's work during 1984. It deals with current nuclear trends, nuclear developments and the fuel cycle, nuclear safety research and licencing, radiological and environmental impacts of nuclear fuel cycle activities, legal affairs, nuclear science, joint undertakings, and, organization and administration

Report 1984

International Nuclear Information System (INIS)

Schwach, G.W.

1985-05-01

The report gives a detailed survey of the work carried out by the Austrian Research Center Seibersdorf in 1984. The working program comprises five main areas: energy and safety, materials research, isotope and radiation techniques, measuring techniques and information processing, environmental protection, health and food, industrial consulting. A special chapter describes the activities of the scientific-technical services. The report further contains lists of lectures held at universities by members of the Research Center, of students working for their theses or diplomas and of publications and patents issued. (Author)

Worldwide deposition of 90Sr through 1984

International Nuclear Information System (INIS)

Larsen, R.J.; Juzdan, Z.R.

1986-10-01

The deposition of 90 Sr in the Northern Hemisphere during 1984 was 0.3 PBq (0.008 MCi), while that of the Southern Hemisphere was 0.1 PBq (0.003 MCi). This resulted in a total deposition on the surface of the earth during 1984 of 0.4 PBq (0.011 MCi). This is the lowest total yearly deposit since the initiation of the Environmental Measurements Laboratory's global fallout program in the mid-1950's. The worldwide cumulative deposit decreased to 357 PBq (9.6 MCi)

3. quarter 2006 sales revenue

International Nuclear Information System (INIS)

2006-10-01

This document presents the sales revenue of the 3. quarter 2006 for the Group AREVA. The sales revenues for the first nine months of 2006 are up by 8,1% to 7,556 millions euros; the nuclear operations are up by 5,2% reflecting strong performance in the front end division; the transmission and distribution division is up by 14%. (A.L.B.)

Has life satisfaction in Norway increased over a 20-year period? Exploring age and gender differences in a prospective longitudinal study, HUNT.

Science.gov (United States)

Lysberg, Frode; Gjerstad, PåL; Småstuen, Milada Cvancarova; Innstrand, Siw Tone; Høie, Magnhild Mjåvatn; Arild Espnes, Geir

2018-02-01

The aim of the present study was to investigate the change in overall life satisfaction for different age groups and between genders over a 20-year period. Data from 1984 to 2008 were extracted from a large prospective longitudinal health study of Nord-Trøndelag (HUNT), Norway. The study included more than 176,000 participants ranging from 20 to 70+ years of age. Data were analysed using logistic regression and adjusted for gender. The analyses revealed an increase in life satisfaction for all age groups from 1984-1986 (HUNT 1) to 1995-1997 (HUNT 2), with the highest levels being reached at 2006-2008 (HUNT 3). For all age groups, the data showed an increase of about 20% for the period from 1984-1986 (HUNT 1) to 1995-1997 (HUNT 2). From 1995-1997 (HUNT 2) to 2006-2008 (HUNT 3), the increase in overall life satisfaction was 16% for the younger age groups, and about 32% for the older age groups (40-69 and 70+ years). Women's scores for overall life satisfaction were higher for nearly all age groups when compared to men using HUNT 3 as a reference. These findings suggest an increase in life satisfaction for all age groups from 1984 to 2008, especially for the older age group (40-69 and 70+ years). The data indicate that women score higher on life satisfaction for most age groups as compared to men.

Une plate-forme sans fil pour electrochimique spectroscopie d'impédance

OpenAIRE

Ghaffari, Seyed Alireza

2015-01-01

Avec l’émergence soutenue de capteurs et de dispositifs électrochimiques innovants, la spectroscopie d'impédance électrochimique est devenue l'un des outils les plus importants pour la caractérisation et la modélisation de la matière ionique et de l'interfaçage des capteurs. La capacité de détecter automatiquement, à l’aide de dispositifs électrochimiques peu couteux, les caractéristiques physiques et chimiques de la matière ionique ouvre une gamme d’application très variée pour la compréhens...

Electronics Department. Progress Report 1984

DEFF Research Database (Denmark)

Risø National Laboratory, Roskilde

This report summarizes the activities in the Electronics Department in 1984. These include work under the headings of informatics, applied laser physics, nuclear geophysics, instrumentation and measuring techniques, and instrumentation consulting, registration and maintenance for the Danish...

Annual report 1984-85

International Nuclear Information System (INIS)

1986-01-01

This report describes the activities of the Australian Safeguards Office (ASO) during the year from 1 July 1984 to 30 June 1985. The ASO's activities in the areas of nuclear materials accountancy and control, systems studies, research and development, and assistance to Government, and in the supporting area of administration, are described

Evaluation of technical problems in 177 cases using 123I-IMP. Autoradiography method for quantitative rCBF study

International Nuclear Information System (INIS)

Hachiya, Takenori; Shoji, Yasuaki; Sugawara, Shigeki; Iida, Hidehiro; Hatazawa, Jun.

1997-01-01

Regional cerebral blood flow can be quantified using SPECT with N-isopropyl-p-( 123 I)-iodoamphetamine (IMP) according to the IMP-ARG method. This study was intended to review our 177 studies including the six technical procedures in this technique, such as the blood sampling volume, the blood sampling time, the radioactivity in blood samples, the PaCO 2 in blood, the scanning started time, and correlations between injection dose and radioactivity in the blood samples. The blood sample was obtained at 10 min in most of studies. The blood volume was 0.7-1.0 ml. The blood radioactivity concentration was 300-500 cps/g in our well-type scintillation counter system. The PaC0 2 was around 40 mmHg in most cases. Significant correlation was observed between the injection dose and the radioactivity counts in the blood (r=0.45), but this study did not suggest the use of the injection dose the cariblation of standardized input function. (author)

Areva, reference document 2006; Areva, document de reference 2006

Energy Technology Data Exchange (ETDEWEB)

NONE

2006-07-01

This reference document contains information on the AREVA group's objectives, prospects and development strategies, particularly in Chapters 4 and 7. It contains information on the markets, market shares and competitive position of the AREVA group. Content: - 1 Person responsible for the reference document and persons responsible for auditing the financial statements; - 2 Information pertaining to the transaction (Not applicable); - 3 General information on the company and its share capital: Information on AREVA, on share capital and voting rights, Investment certificate trading, Dividends, Organization chart of AREVA group companies, Equity interests, Shareholders' agreements; - 4 Information on company operations, new developments and future prospects: Overview and strategy of the AREVA group, The Nuclear Power and Transmission and Distribution markets, The energy businesses of the AREVA group, Front End division, Reactors and Services division, Back End division, Transmission and Distribution division, Major contracts, The principal sites of the AREVA group, AREVA's customers and suppliers, Sustainable Development and Continuous Improvement, Capital spending programs, Research and development programs, intellectual property and trademarks, Risk and insurance; - 5 Assets - Financial position - Financial performance: Analysis of and comments on the group's financial position and performance, 2006 Human Resources Report, Environmental Report, Consolidated financial statements, Notes to the consolidated financial statements, AREVA SA financial statements, Notes to the corporate financial statements; 6 - Corporate Governance: Composition and functioning of corporate bodies, Executive compensation, Profit-sharing plans, AREVA Values Charter, Annual Combined General Meeting of Shareholders of May 3, 2007; 7 - Recent developments and future prospects: Events subsequent to year-end closing for 2006, Outlook; 8 - Glossary; 9 - Table of concordance.

Current Block Groups for Guadalupe County, New Mexico, 2006se TIGER

Data.gov (United States)

Earth Data Analysis Center, University of New Mexico — The 2006 Second Edition TIGER/Line files are an extract of selected geographic and cartographic information from the Census TIGER database. The geographic coverage...

Current Block Groups for Hidalgo County, New Mexico, 2006se TIGER

Data.gov (United States)

Earth Data Analysis Center, University of New Mexico — The 2006 Second Edition TIGER/Line files are an extract of selected geographic and cartographic information from the Census TIGER database. The geographic coverage...

Current Block Groups for Luna County, New Mexico, 2006se TIGER

Data.gov (United States)

Earth Data Analysis Center, University of New Mexico — The 2006 Second Edition TIGER/Line files are an extract of selected geographic and cartographic information from the Census TIGER database. The geographic coverage...

Report on the year 1984

International Nuclear Information System (INIS)

1985-01-01

This annual report accounts for the market situation, marketing, structure of cooperation (URENCO), centrifuge production and development, financial aspects and personnel affairs, during the year 1984, of Ultra-Centrifuge Nederland n.v. (H.W.). (H.W.). figs.; tabs

Annual report on radioactive discharges and monitoring of the environment 1984

International Nuclear Information System (INIS)

1985-01-01

Information is given on the liquid, airborne, and solid radioactive discharges through authorised outlets, and on environmental monitoring for all of BNFL's works and sites for 1984; ie Sellafield site and Drigg storage and disposal site; Chapelcross works; Springfields works and Ulnes Walton disposal site; Capenhurst works. Included is assessment of radiation doses to representative members of the most highly exposed group of the general population for the most important environmental pathways. (author)

Observations of a low-frequency cutoff in magnetospheric radio noise received on Imp 6

International Nuclear Information System (INIS)

Vesecky, J.F.; Frankel, M.S.

1975-01-01

Observations of magnetospheric radio noise by the Goddard Space Flight Center radio experiment on the Imp 6 spacecraft have revealed a quasi-continuous component at frequencies between 30 and 110 kHz. When the spacecraft is in the interplanetary medium or the magnetosheath, a low-frequency cutoff often characterizes the otherwise power law (f - /sup alpha/) spectrum of this noise. A positive correlation is observed between this cutoff frequency f) and the solar wind plasma frequency f), deduced from the Los Alamos plasma experiment on the same spacecraft; on the average, f)approx. =1.3f). If one pictures the magnetosheath as a homogeneous layer of plasma lying between the radio noise source (at Lapprox.4--7) and the spacecraft in the interplanetary medium and having an electron density 2--3 times that of the solar wind, then one will expect f)approximately-greater-than2 1 / 2 f)--3 1 / 2 f). Within the limits of experimental error this simple model correctly accounts for the observations. A rough calculation shows that radio wave scattering by electron density fluctuations in the magnetosheath plasma is likely to be important for frequencies below 200 kHz. However, the effects of such scattering cannot be detected in the Imp 6 observations considered here because neither concurrent measurements nor sufficiently accurate models of the necessar []magnetosheath plasma parameters are presently available

Brain imaging with 123I-IMP-SPECT in migraine between attacks

International Nuclear Information System (INIS)

Schlake, H.P.; Boettger, I.G.G.; Grotemeyer, K.H.; Husstedt, I.W.

1989-01-01

123 I-IMP-SPECT brain imaging was performed in patients with classic migraine (n = 5) and migraine accompagnee (n = 18) during the headache-free interval. A regional reduction of tracer uptake into brain was observed in all patients with migraine accompagnee, while in patients with classic migraine only one case showed an area of decreased activity. The most marked alteration was found in a patient with persisting neurological symptoms (complicated migraine). In most cases the areas of decreased tracer uptake corresponded to headache localization as well as to topography of neurologic symptoms during migraine attacks. It may be concluded that migraine attacks occur in connection with exacerbations of preexisting changes of cerebral autoregulation due to endogenous or exogenous factors

The history of gay bathhouses. 1984.

Science.gov (United States)

Bérubé, Allan

2003-01-01

Public policy regarding bathhouses has been criticized as being based on political expediency rather than on medical or social science. To affect that shortcoming, we include here a brief history of gay bathhouses. The history of the baths is rarely told, but whenever it is told it necessarily reflects the times in which it was written. For that reason, we include a history written in 1984, at the time that much of what was known about AIDS, routes of transmission and the role of the bathhouses was very much in flux. This history not only gives a context for the current discussion, but also allows the reader to see the history from that distant point in time. This paper was first published in December 1984 as an article in Coming Up!, a lesbian and gay community newspaper published monthly in San Francisco (California). It was later edited and reprinted in a book titled Policing Public Sex (1996). The version of the paper presented here is from the original 1984 article (pp. 15-19); several images appeared with the article that are not reproduced here. As with all the reprinted papers in this volume, no editorial changes were made to the paper and only minor typographical errors were corrected.

Evaluation of crossed cerebellar diaschisis in 30 patients with major cerebral artery occlusion by means of quantitative I-123 IMP SPECT

Energy Technology Data Exchange (ETDEWEB)

Miyazawa, Nobuhiko; Toyama, Keiji; Arbab, A.S.; Arai, Takao; Nukui, Hideaki [Yamanashi Medical Univ., Tamaho (Japan); Koizumi, Kiyoshi

2001-12-01

Quantitative crossed cerebellar diaschisis (CCD) and the correlation with a reduction in supratentorial regional cerebral blood flow (rCBF) and cerebrovascular reserve capacity (CVR) were investigated in clinically stable patients with major cerebral artery occlusion by the iodine-123-N-isopropyl-p-iodoamphetamine (I-123 IMP) single photon emission computed tomography (SPECT) method. Thirty patients with major cerebral artery occlusion underwent SPECT by the I-123 IMP autoradiographic method. Regional CBF was measured in the cerebral hemisphere, frontal and parietal lobes, temporo-parietal lobe, and cerebellum both at rest and after administration of acetazolamide. Eighteen of 30 patients (60%) had CCD. CCD was significantly related to magnetic resonance imaging evidence of infarction. Quantitative CCD was 17% and the CVR in the cerebellum was preserved in patients with CCD. There was a significant difference in CBF and CVR between the affected and normal sides in all regions of interest in the patients without CCD [CBF (ml/100 g/min): hemisphere (H), normal side (N): 31.4{+-}6.8, affected side (A): 27.5{+-}7.4; p<0.05. CVR: H, N: 0.56{+-}0.38, A: 0.42{+-}0.18; p<0.01]. CCD is common in patients with major cerebral artery occlusion, and quantitative I-123 IMP SPECT is helpful in detecting CCD in clinically stable patients with occlusion of major cerebral arteries. (author)

Galactic cosmic ray gradients, field-aligned and latitudinal, among Voyagers 1/2 and IMP-8

International Nuclear Information System (INIS)

Roelof, E.C.; Decker, R.B.; Krimigis, S.M.; Venkatesan, D.; Lazarus, A.J.

1982-01-01

The tandem Earth-Jupiter trajectories of the Voyager 1/2 spacecraft, combined with baseline measurements from the earth-orbiting IMP-7/8 spacecraft, provide the first opportunity for unambiguously separating latitude from radial or field-aligned effects in galactic cosmic ray gradients. Anti-coincidence solid-state detectors on the Voyager 1/2 LECP experiment measure nucleons > or approximately 20 MeV/nuc with large (28 cm 2 ) omnidirectional geometry factors. Anti-coincidence scintillators on the IMP-7/8 CPME with omnidirectional geometry factors comparable to those on Voyager measure nucleons > or approximately 35 MeV/nuc. Because the Voyagers are well-connected via the interplanetary magnetic field (IMF) to the near-Earth vicinity throughout their transit from 1-5 AU (September 1977 - February 1979), we obtained the first direct measurement of field-aligned gradients, i.e., those that do not depend upon ''corotation'' from one spacecraft to another over many days. Another new result is the unambiguous identification of nonuniform latitudinal gradients approximately 2-5% degree -1 in structures lasting 10-30 days. There is additional evidence for somewhat smaller latitudinal gradients, north to south and probably mixed with small field-aligned gradients -1 , which persist for several solar rotations

Differential in Utilization of Maternal Care Services in Empowered Action Group States, India (1990-2006

Directory of Open Access Journals (Sweden)

Jeetendra Yadav

2016-03-01

Full Text Available Background: Low use of maternal care services is one of the reasons why child mortality and maternal mortality is still considerably high in India. Most maternal deaths are preventable if mothers receive essential health care before, during, and after childbirth. In India, the eight socioeconomically backward states referred to as the Empowered Action Group (EAG states; lag behind in the demographic transition and low utilization of maternal health care services. Addressing the maternity care needs of women may have considerable ramifications for achieving the Millennium Development Goal (MDG – 5.Aims & Objectives:  To explore the prevalence, trends and factors associated with the utilization of maternal care services in Empowered Action Group States, India (1990-2006.Material Methods: Data from three rounds of the round of the Demographic and Health Survey (DHS, known as the National Family Health Survey (NFHS of India were analyzed. Bivariate and multivariate-pooled logistic regression model were applied to examine the utilization of the maternal and child health care trends over time.Result: The results from analysis indicate that the full ANC and skilled birth attendant (SBA has increased from 17% and 20% to 25% and35% respectively during the last one and half decade (1990-2006.Conclusion: Various socioeconomic and demographic factors are associated with the utilization of maternal care services in EAG states, India. Promoting the use of family planning, female education, targeting vulnerable groups such as poor, illiterate, high parity women, involving media and grass root level workers and collaboration between community leaders and health care system could be some important policy level interventions to address the unmet need of maternal and child health care services among women. The study concludes that much of these differentials are social constructs that can be reduced by prioritizing the needs of the disadvantaged and adopting

Differential in Utilization of Maternal Care Services in Empowered Action Group States, India (1990-2006

Directory of Open Access Journals (Sweden)

Jeetendra Yadav

2016-03-01

Full Text Available Background: Low use of maternal care services is one of the reasons why child mortality and maternal mortality is still considerably high in India. Most maternal deaths are preventable if mothers receive essential health care before, during, and after childbirth. In India, the eight socioeconomically backward states referred to as the Empowered Action Group (EAG states; lag behind in the demographic transition and low utilization of maternal health care services. Addressing the maternity care needs of women may have considerable ramifications for achieving the Millennium Development Goal (MDG – 5. Aims & Objectives:  To explore the prevalence, trends and factors associated with the utilization of maternal care services in Empowered Action Group States, India (1990-2006. Material Methods: Data from three rounds of the round of the Demographic and Health Survey (DHS, known as the National Family Health Survey (NFHS of India were analyzed. Bivariate and multivariate-pooled logistic regression model were applied to examine the utilization of the maternal and child health care trends over time. Result: The results from analysis indicate that the full ANC and skilled birth attendant (SBA has increased from 17% and 20% to 25% and35% respectively during the last one and half decade (1990-2006. Conclusion: Various socioeconomic and demographic factors are associated with the utilization of maternal care services in EAG states, India. Promoting the use of family planning, female education, targeting vulnerable groups such as poor, illiterate, high parity women, involving media and grass root level workers and collaboration between community leaders and health care system could be some important policy level interventions to address the unmet need of maternal and child health care services among women. The study concludes that much of these differentials are social constructs that can be reduced by prioritizing the needs of the disadvantaged and

Miners' strike 1984-85

Energy Technology Data Exchange (ETDEWEB)

Brown, L; Salter, S [comps.

1985-01-01

References relating to the 1984-85 UK miners strike are listed under the following subject headings: events and analysis - a chronological record; short term effects - coal stocks and supplies, electricity supplies, financial, industrial and economic; the miners and their leadership; social aspects - civil liberties, media coverage, mining communities, picketing, policing, the future; pit closures. 240 references.

Quantitative iodine-123 IMP imaging of brain perfusion in schizophrenia

International Nuclear Information System (INIS)

Cohen, M.B.; Lake, R.R.; Graham, L.S.

1989-01-01

Decreased perfusion in the frontal lobes of patients with chronic schizophrenia has been reported by multiple observes using a variety of techniques. Other observers have been unable to confirm this finding using similar techniques. In this study quantitative single photon emission computed tomography brain imaging was performed using p,5n [ 123 I]IMP in five normal subjects and ten chronically medicated patients with schizophrenia. The acquisition data were preprocessed with an image dependent Metz filter and reconstructed using a ramp filtered back projection technique. The uptake in each of 50 regions of interest in each subject was normalized to the uptake in the cerebellum. There were no significant confirmed differences in the comparable ratios of normal subjects and patients with schizophrenia even at the p = 0.15 level. Hypofrontality was not observed

Hitler's Reich Viewed from 1984

Science.gov (United States)

Ward, James E.

1971-01-01

Viewed within a context of Orwell's 1984," the author's visit to East Germany, and particularly to the Museum for German History, revealed the efforts of an authoritarian regime to manipulate the thoughts and directions of that society to its own advantage. (JB)

Nuclear excitations and reaction mechanisms. Progress report, 1 August-31 July 1984

International Nuclear Information System (INIS)

Fallieros, S.; Levin, F.S.

1984-01-01

This progress report describes activities of the Nuclear Theory group at Brown University during the period 1 August 1983 to 31 July 1984. Completed and ongoing research include various theoretical and numerical studies of few-particle systems, nuclear reaction models, nuclear electroexcitation and photon scattering from nuclei. In addition, research on atomic and molecular structure has essentially been concluded and no further DOE-supported research in this area is anticipated

Forest science in the South - 2006

Science.gov (United States)

Southern Research Station USDA Forest Service

2007-01-01

Welcome to the Southern Research Station's 2006 Forest Science in the South. Our summary highlights key accomplishments and activities from this past fiscal year, October 1, 2005, through September 30, 2006.This was a dynamic year for the Station! We recently realigned our 28 research work units (RWUs) into 15 RWUs grouped under five science areas –...

Sergey KRAVCHENKO (1984-2008)

CERN Document Server

IT Department

2008-01-01

We were deeply saddened to hear the death of our former colleague, Sergey Kravchenko, which occurred in an accident in Moscow on 10th July, in his 24th year. Sergey came first to CERN in 2006 then returned in AIS between June 2007 and June 2008 to participate in the development of various HR related IT solutions. Sergey had just left CERN less than 2 weeks ago. We offer our sincerest condolences and deepest sympathy to his family. His friends and former colleagues of the AIS Group

Electronics Department progress report 1984

International Nuclear Information System (INIS)

1985-11-01

This report summarizes the activities in the Electronics Department in 1984. These include work under the headings of informatics, applied laser physics, nuclear geophysics, instrumentation and measuring techniques, and instrumentation consulting, registration and maintenance for the Danish Research Council and Risoe National Laboratory. (author)

Nuclear safety review for 1984

International Nuclear Information System (INIS)

1985-08-01

This publication is based on the fourth Nuclear Safety Review prepared by the IAEA Secretariat for presentation to the Board of Governors. It discusses relevant international activities in 1984 and the current status of nuclear safety and radiation protection, and looks ahead to anticipated developments

Mindful Parenting Assessed Further : Psychometric Properties of the Dutch Version of the Interpersonal Mindfulness in Parenting Scale (IM-P)

NARCIS (Netherlands)

de Bruin, Esther I.; Zijlstra, Bonne J H; Geurtzen, Naline; van Zundert, Rinka M P; van de Weijer-Bergsma, Eva|info:eu-repo/dai/nl/304834335; Hartman, Esther E.; Nieuwesteeg, Anke M.; Duncan, Larissa G.; Bögels, Susan M.

Psychometric properties of the Dutch version of the Interpersonal Mindfulness in Parenting Scale (IM-P) were studied in a general population sample of mothers of adolescents (n = 866) (study 1). A six-factor structure (29 items) emerged using exploratory factor analysis. A main difference from the

Research in elementary particle physics. Progress report, May 1, 1983-February 29, 1984

International Nuclear Information System (INIS)

Chan, L.H.; Haymaker, R.; Imlay, R.; Metcalf, W.

1984-01-01

Theoretical work on an effective low energy theory of hadrons, dynamical symmetry breaking, supersymmetry and the phenomenology of Higgs Particles is described. Also, the high energy experimental group at Louisiana State University is collaborating with Columbia, Stony Brook, and the Max Planck Institute on an experiment in progress at the North Area of CESR. This experiment is the study of electron-positron annihilations in the region of the new upsilon family of particles with an apparatus optimized for detecting leptons and photons. The UPSILON''' has been observed with properties consistent with its being above threshold for B meson production and several decay modes have been studied in detail. The ππ decays of the UPSILON' and UPSILON'' have also been measured as well as electronmagnetic transition among the b anti b bound states. LSU has contributed the muon detector for the experiment. We expect to conclude our participation in this experiment by May 1984. The LSU group has joined a collaboration to measure neutrino oscillations at Los Alamos. We are now building the equipment for this experiment and should be taking data by the end of 1984. Publications are listed

Quantification of regional cerebral blood flow (rCBF) measurement with one point sampling by sup 123 I-IMP SPECT

Energy Technology Data Exchange (ETDEWEB)

Munaka, Masahiro [University of Occupational and Enviromental Health, Kitakyushu (Japan); Iida, Hidehiro; Murakami, Matsutaro

1992-02-01

A handy method of quantifying regional cerebral blood flow (rCBF) measurement by {sup 123}I-IMP SPECT was designed. A standard input function was made and the sampling time to calibrate this standard input function by one point sampling was optimized. An average standard input function was obtained from continuous arterial samplings of 12 healthy adults. The best sampling time was the minimum differential value between the integral calculus value of the standard input function calibrated by one point sampling and the input funciton by continuous arterial samplings. This time was 8 minutes after an intravenous injection of {sup 123}I-IMP and an error was estimated to be {+-}4.1%. The rCBF values by this method were evaluated by comparing them with the rCBF values of the input function with continuous arterial samplings in 2 healthy adults and a patient with cerebral infarction. A significant correlation (r=0.764, p<0.001) was obtained between both. (author).

Rygevaner blandt 11-15-årige, 1984-1994

DEFF Research Database (Denmark)

Due, E P; Holstein, B E

1997-01-01

The objectives are to describe smoking habits among 11-15-year olds in Denmark in the period 1984-1994 and to describe the association between smoking and social background factors. The article reports data about children at the age of 11, 13 and 15 years from four cross-sectional studies in 1984...... smoke every day is 0%, 1%, 3%, 4%, 17%, and 11%. In conclusion, smoking habits among children changed considerably from the 1950's to 1980's. The smoking habits have not changed much since the 1980's apart from a slight delay in first smoking-experience. Udgivelsesdato: 1997-Feb-17......-1985, 1988, 1991 and 1994 (n = 678, 1667, 1860 and 4046) based on stratified random samples of schools. Data were collected by standardized questionnaires. Median age for first smoking experience changed from approx 12 years in 1984-1985 to approx. 14 years in 1994. The proportion of smokers among 15 year...

1984 availability of the world's nuclear power plants

International Nuclear Information System (INIS)

Szeless, A.; Oszuszky, F.

1985-01-01

This survey of the availability of the world's nuclear power plants in 1984 coveres 250 units (the CMEA countries excluded) with an aggregate 184,500 MWe, which are arranged by types of reactor and geographic distribution. The utilization of nuclear power plant capacity attained an average of 66% in 1984, which is an increase by 3 percentage points in the utilization of capacity over the previous year's level (63%). Capacity utilization in pressurized water reactors 1984 (69%) was 4 percentage points higher than it was in boiling water reactors (65%). The ranking list of the world's nuclear power plants is headed by one heavy water reactor and one gas cooled reactor each (98%), followed by five generating units, i.e., two pressurized water reactors, two boiling water reactors, and one heavy water reactor (all 95%). The best German nuclear power plants were Grafenrheinfeld (89%, position No. 20) and Unterweser and Stade (88%, position No. 25). (orig.) [de

The expert group health research and care after disasters and environmental crises: an analysis of research questions formulated by Dutch health authorities for the expert group between 2006 and 2016.

NARCIS (Netherlands)

Alting, D.; Dückers, M.L.; Yzermans, J.

2017-01-01

Study/Objective: The aim of this study is (1) to examine developments in the research questions, submitted to the Expert Group Health Research and Care after Disasters and Environmental Crises between 2006 and 2016, and (2) to explore implications of the research questions for the nature of advice

Ocean station data collected using bottle casts from the ALMIRANTE SALDANHA in the South Atlantic Ocean from 1984-02-19 to 1984-03-26 (NODC Accession 9000034)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Ocean station data were collected using seechi disk, meteorological sensors, and bottle casts in the South Atlantic Ocean from 19 February 1984 to 26 March 1984. The...

Progress report of Applied Physics Division. July 1984 - June 1985

International Nuclear Information System (INIS)

2004-01-01

The activities of the Division during 1984/85 were again directed towards the general program objectives of the past two years. A shift in emphasis resulted in some organization changes. The increased importance of nuclear safeguards research in the Government's support for the International Atomic Energy Agency program has prompted a re-arrangement of the nuclear physics and science activities. Dr JR. Bird holds the responsibility for the Nuclear Science Section comprising the Nuclear Applications Group, Biomedical and Reactor Applications Group and the Neutron Scattering Group. The newly formed Safeguards and Nuclear Physics Section is headed by Dr J.W. Boldeman and includes the Safeguards Group and Nuclear Physics Group. The organization of the remainder of the Division is unchanged. The work on the electronic properties of hydrogen in silicon has been particularly rewarding and the plasma physics studies received recognition with an IAEA sponsored workshop on Compact Torus Research held in Sydney in March 1985 (author)

Progress report of Applied Physics Division. July 1984 - June 1985

Energy Technology Data Exchange (ETDEWEB)

NONE

2004-07-01

The activities of the Division during 1984/85 were again directed towards the general program objectives of the past two years. A shift in emphasis resulted in some organization changes. The increased importance of nuclear safeguards research in the Government's support for the International Atomic Energy Agency program has prompted a re-arrangement of the nuclear physics and science activities. Dr JR. Bird holds the responsibility for the Nuclear Science Section comprising the Nuclear Applications Group, Biomedical and Reactor Applications Group and the Neutron Scattering Group. The newly formed Safeguards and Nuclear Physics Section is headed by Dr J.W. Boldeman and includes the Safeguards Group and Nuclear Physics Group. The organization of the remainder of the Division is unchanged. The work on the electronic properties of hydrogen in silicon has been particularly rewarding and the plasma physics studies received recognition with an IAEA sponsored workshop on Compact Torus Research held in Sydney in March 1985 (author)

Three-dimensional surface display with [sup 123]I-IMP brain perfusion imaging in patients with dementia

Energy Technology Data Exchange (ETDEWEB)

Tomino, Yoshio; Tachibana, Hisao; Sugita, Minoru [Hyogo Coll. of Medicine, Nishinomiya (Japan)

1994-04-01

We reconstructed three-dimensional (3D) surface images from SPECT data with N-isopropyl-p [[sup 123]I]-iodo-amphetamine ([sup 123]I-IMP) in 27 patients with Parkinson's disease (group 1), 16 patients with Alzheimer's disease (group 2), 9 patients with Binswanger's disease (group 3), and 11 elderly normal subjects (control group). Three-D reconstruction was performed using distance-shaded method at the threshold levels at intervals of 5% from 45% to 80%. In the control group, no perfusion defects were found in any region at threshold values below 60%, although the frontal and temporal cortices occasionally showed perfusion defects at threshold levels from 60% to 80%. In the group 1 of patients with dementia, perfusion defects were diffuse, particularly in the parietal and temporal cortices even at a threshold of 45%. The group 2 also showed diffuse perfusion defects, particularly in parietal and temporal cortices even at threshold levels as low as 45%. The primary visual cortex was less affected in this group. The demented patients in the group 1 demonstrated perfusion defects similar to those of patients in the group 2, although perfusion defects were more prominent in the group 2. In the group 3, patchy perfusion defects were found most frequently in the frontal region. Perfusion defects in the cerebellum and sensory motor cortex were more frequent in the group 3 than the other two groups, as well as the control group. The demented patients in the group 1 showed perfusion defects in the temporal and parietal cortices and demonstrated a perfusion pattern similar to those in the group 2. The patterns of brain perfusion in the group 3 were obviously different from those in the other two groups. In conclusion, 3D surface display of brain perfusion imaging may be useful for evaluating the cortical hypoperfusion regions in patients with dementia. It may also be of value in the differential diagnosis of cognitive disorders. (J.P.N.).

INDAG newsletter, No. 6, September 2006

International Nuclear Information System (INIS)

2006-09-01

The current issue presents information about the following: recent activities in Nuclear desalination in Member States - The eighth meeting of the International Nuclear Desalination Advisory Group (INDAG), held from 6 to 8 February 2006 at the VIC, Vienna; an overview of El- Dabaa RO experimental facility; coupling of LTMED with KANUPP, Pakistan; highlights of ongoing and future activities of the IAEA (2005-2006)

Contraceptive sterilization among Canadians, 1984-1995

Directory of Open Access Journals (Sweden)

Krishnan, Vijaya

2004-01-01

Full Text Available EnglishPrior to early 1970s, traditional methods were the principal means ofcontrolling the number and spacing of births. Today, an estimated 57 per cent of the world's marriedwomen use contraceptives and half use modern methods such as medical sterilizations. Recent statisticssuggest that Canada has the highest sterilization rate in the Western world. This paper presentsfindings of research examining sterilization trends in Canada with respect to changing patterns in theuse of modern contraceptives, using data from the 1984 Canadian Fertility Survey (CFS and the 1995General Social Survey (GSS. The main finding is that there is a decrease in the use of tubal ligationand an increase in the use of hysterectomy over the period 1984-1995. Less educated women are morelikely to be in the forefront of modern methdos of contraception.FrenchAvant les années 1970, les méthodes traditionnelles représentaient le principalmoyen de contrôler et d’espacer le nombre de naissances. De nos jours, onestime que 57 pour cent des femmes mariées dans le monde entier utilisent unmoyen contraceptif et la moitié utilise des méthodes modernes telles que lastérilisation. Les dernières statistiques indiquent que le Canada compte le tauxde stérilisations le plus élevé dans le monde occidental. Cet article présente lesconclusions de recherches portant sur les tendances en matière de stérilisation auCanada en ce qui concerne les modèles changeants d’utilisation de moyens decontraception modernes et ce, à partir de données de l’Enquête canadienne sur lafécondité de 1984 et de l’Enquête sociale générale (ESG de 1995. La principaleconclusion qui en est ressortie est une réduction de la ligature des trompes etune augmentation du nombre d’hystérectomies de 1984 à 1995. Les femmesmoins éduquées sont plus portées à se trouver au premier plan des méthodes decontraception modernes.

Regional cerebral blood flow in Parkinson's disease measured with N-isopropyl-p-[[sup 123]I]iodoamphetamine (IMP) SPECT

Energy Technology Data Exchange (ETDEWEB)

Odano, Ikuo; Nishihara, Mamiko; Hayashi, Hiroko; Higuchi, Shoichi; Sakai, Kunio [Niigata Univ. (Japan). School of Medicine; Ishikawa, Atsushi; Ibayashi, Katsuhiko

1992-09-01

N-isopropyl-p-[[sup 123]I]iodoamphetamine (IMP) SPECT studies were performed on 21 patients (13 females; 45-73 yrs) with idiopathic Parkinson's disease (PD) and 10 age-matched normal controls (39-69 yrs). Regional cerebral blood flow (rCBF) was quantitatively measured by the arterial blood sampling method. When compared with normal controls, global CBF, and rCBF in the frontal cortex and in the basal ganglia were reduced 22.1% (p<0.01), 25.0% (p<0.05) and 25.6% (p<0.01), respectively. The reduction of rCBF in the basal ganglia was significantly correlated (p<0.05) with symptoms such as gait disturbance, frozen gait and motor disability score. However, no significant correlation was observed between the severity of dementia and any regional reduction of CBF, including the frontal or parietal cortices. These data show that the severity of dementia in PD may be related to other factors but not with CBF. Quantification of rCBF with [sup 123]I-IMP SPECT imaging is useful for evaluation and follow-up of patients with PD. (author).

Intermediate-energy nuclear theory. Final report, July 1, 1976-August 31, 1984

International Nuclear Information System (INIS)

Bryan, R.A.

1985-02-01

We summarize the research accomplishments of the Texas A and M Medium-Energy Theory Group which was funded by the Department of Energy from July 1976 through August 1984. Our research was mainly in the area of nucleon-nucleon and NNπ theory and data analysis, although some effort was also devoted to the elementary-particle aspects of these hadrons in order to better understand the NN force. Publications and reports are listed

Annual report 1984-85

International Nuclear Information System (INIS)

1985-01-01

A full report of the Universities research report for 1984-5 is given. This covers the research programme with a brief description of each major programme, the activation analysis service, where a new gamma spectroscopy system was installed in 1985, the teaching and service training courses run at the reactor and a report on the reactor operation and site safety, including operational statistics and faults. (U.K.)

Uranium in Canada: 1984 assessment of supply and requirements

International Nuclear Information System (INIS)

1985-09-01

The success of uranium exploration efforts in Canada has continued, resulting in an overall increase in domestic uranium resource estimates for the principal resource categories. In 1984, Canada's five primary uranium producers employed some 5,800 people at their mining and milling operations, and produced concentrates containing some 11 170 tU. In 1984 the resource estimates were (in tonnes U recoverable): measured - 54 000; indicated - 233 000; inferred - 264 000. Canada's projected annual primary uranium production capability will stabilize at some 12 000 tU through the remainder of the 1980s. Should market conditions warrant, additional production centres could be developed to raise production capability to a level of 15 000 tU by the latter half of the 1990s. Prognosticated resources exploitable at uranium prices of $300/kg U or less are estimated to amount to 292 000 tU. Speculative resources of interest at prices of $300/kg U or less, in areas assessed during 1984, are thought to total approximately one million tU. Uranium exploration expenditures in Canada in 1983 and 1984 were an estimated $41 and $35 million, respectively. Exploration drilling and surface development drilling in 1983 and 1984 were reported to be 153 000 m and 197 000 m, respectively, some 85 per cent of which was in Saskatchewan. Canada's known uranium resources, recoverable at uranium prices of $150/kg U or less, are more than sufficient to meet the 30-year fuelling requirements of those reactors in Canada that are either in operation now or committed or expected to be in-service by 1995. Over the longer term, there is significant potential for discovering additional uranium resources in Canada

Spread of clonally related Escherichia coli harboring an IncA/C1 plasmid encoding IMP-8 and its recruitment into an unrelated MCR-1-containing isolate.

Science.gov (United States)

Elena, Alan; Cejas, Daniela; Magariños, Francisco; Jewtuchowicz, Virginia; Facente, Andrea; Gutkind, Gabriel; Di Conza, José; Radice, Marcela

2018-04-16

Ten IMP-8-producing Escherichia coli isolates were recovered from the surveillance cultures of a neonatal intensive care unit, of which eight were clonally related. A 168.2-kb- bla IMP-8 plasmid was fully sequenced, and it corresponded to the recently described IncA/C1-ST13. This plasmid was detected in all isolates, even in those no clonally related. One unrelated isolate was also resistant to colistin and positive for mcr-1. This marker was located in a 62.7-kb-IncI2 plasmid, which was also fully sequenced. Copyright © 2018 American Society for Microbiology.

Correlation of the cognitive function and the duration of the illness with the regional cerebral blood flow in the patients with Parkinson's disease. Objective evaluation using stereotactic extraction estimation analysis in 123I-IMP SPECT

International Nuclear Information System (INIS)

Sakai, Toshiyuki; Kuzuhara, Shigeki

2006-01-01

The objective of this study was to investigate the correlation of the cognitive function and the duration of the illness with the regional cerebral blood flow (rCBF) in patients with Parkinson's disease (PD), by means of an objective diagnostic index of brain imaging, stereotactic extraction estimation (SEE) of 123 I-IMP SPECT. We examined 123 I-IMP SPECT in 24 patients with PD (age=71.79±5.18 years; the Mini-Mental State Examination: MMSE score=21.46±7.62 points; the duration of the illness=6.63±3.91 years; Yahr scale=3.29±0.74). A contrast database was created by averaging extracted database sets of the contrast group (numbers=14 cases; age=74.64±5.99 years, the MMSE score≥29 points). We applied SEE for Z-score images of three-dimensional stereotactic surface projection analysis (3D-SSP) for 123 I-IMP SPECT, and calculated Z * extent ratio by taking advantage of severity of Z-score (the mean value) with extent ratio (%) in the frontal, occipital, temporal, parietal and posterior cingulate cortices, and precuneus, respectively. We investigated the correlation coefficient between the MMSE score and Z * extent ratio, and between the duration of the illness and Z * extent ratio in the six regions. In addition, we compared Z * extent ratio in the six regions between the non-demented group (numbers=12 patients; MMSE≥24 points) and the demented group (numbers=12 patients; E score≤23 points). There were negative correlations between the MMSE score and Z * extent ratio in the temporal (p * extent ratio in the frontal (p * extent ratio was significantly high only in the posterior cingulate cortex (p<0.05) in the demented group. SEE for Z-score images of 3D-SSP revealed a close relationship between the decline of the MMSE score and the duration of the illness, and the perfusion reduction of the posterior cingulate cortex in patients with PD. These findings suggest that the perfusion reduction of the posterior cingulate cortex reflects the decline of cognitive

7 CFR 29.1036 - Mixed Group (M).

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Mixed Group (M). 29.1036 Section 29.1036 Agriculture... Type 92) § 29.1036 Mixed Group (M). This group consists of tobacco from three or more groups or two distinctly different groups which are mixed together in various combinations. [49 FR 16755, Apr. 20, 1984...

Gaz de France 2006 annual report; Gaz de France 2006 rapport d'activite

Energy Technology Data Exchange (ETDEWEB)

NONE

2006-07-01

Gaz de France is major European energy utility, which produces, purchases, transports, distributes and sells natural gas, electricity and related services for its residential, corporate and local government customers. Its strategic focuses are to develop an ambitious marketing strategy, pursue a supply and procurement policy that guarantees the Group's competitiveness, confirm its position as a benchmark infrastructure manager, and speed up its profitable growth in Europe. Gaz de France aligns its strategy with a concrete and ambitious sustainable development policy. Its growth model is based on responsiveness to customers and constructive dialogue with its employees and partners. This document is the activity report of the group for the year 2006. It presents: 1 - the corporate profile of the group; 2 - its strategies (energy, energy supply, infrastructures); 3 - its financial highlights; 4 - its governance, shareholders and human resources; 5 - the activities of the group (exploration and production, energy procurement, energy sales, services, transmission France, storage France, LNG terminals, distribution France, transmission and distribution international, research and development); 6 - its 2006 financial data and financial summary.

Vérification de programmes OCaml fortement impératifs avec Why3

OpenAIRE

Filliâtre , Jean-Christophe; Pereira , Mário; Melo De Sousa , Simão

2018-01-01

International audience; Cet article présente une méthodologie pour prouver des programmes OCaml fortement impératifs avec l'outil de vérification déductive Why3. Pour un programme OCaml donné, un modèle mémoire spécifique est construit et on vérifie un programme Why3 qui le mani-pule. Une fois la preuve terminée, on utilise la capacité de Why3 à traduire ses programmes vers le langage OCaml, tout en remplaçant les opérations sur le modèle mémoire par les opérations correspondantes sur des typ...

Rocky Mountain Arsenal Ecological Chemical Data (1984-1985)

Science.gov (United States)

1986-03-01

0 0.00 0.05 LT DL US6 EPA ERR - ERR P,.ACOL LIV 3001 84242- 84243 CIMP 2 0 0.00 0.05 LT OL U66 ERR ERR - ERR PHACOL LIV O’ i4279- -4271 01? M0. 0...001 1094 M 84242 85058 CPMS02 LT 2.000 -1 UGG DBCP LT 2.000 -2 U6S cIMP LT 5.000 -2 UGS DITH LT 2.000 -1 U6G DLDRN 5.000 -2 UGG ENORN LT 2.000 -2 UGG

Current Block Groups for San Juan County, New Mexico, 2006se TIGER

Data.gov (United States)

Earth Data Analysis Center, University of New Mexico — The 2006 Second Edition TIGER/Line files are an extract of selected geographic and cartographic information from the Census TIGER database. The geographic coverage...

Energy Materials Coordinating Committee (EMaCC) annual technical report, fiscal year 1984 with fiscal year 1985 data

Energy Technology Data Exchange (ETDEWEB)

None

1985-07-01

The Department of Energy funded about 374 million dollars of materials science and technology activities in both fiscal years 1984 and 1985. These funds and the commensurate program management responsibilities resided in 21 DOE program offices, each of which has its own mission and responsibilities. The Energy Materials Coordinating Committee (EMaCC) provides a formal mechanism to insure coordinated planning and maximum programmatic effectiveness for the Department's 374 million dollar per year materials effort. The EMaCC reports to the Director of the Office of Energy Research who in turn has oversight responsibilities for proper coordination of the technical programs of the Department. In carrying out this responsibility, EMaCC hosts meetings, organizes working groups, and publishes an annual technical report. This report is mandated by the EMaCC Terms of Reference. Its purpose is to disseminate information on the DOE materials programs for more effective coordination. It describes the materials research programs of various offices and divisions within the Department for FY 1984, contains funding information for FYs 1984 and 1985, and summarizes EMaCC activities for FY 1985.

Energy Materials Coordinating Committee (EMaCC) annual technical report, fiscal year 1984 with fiscal year 1985 data

International Nuclear Information System (INIS)

1985-07-01

The Department of Energy funded about 374 million dollars of materials science and technology activities in both fiscal years 1984 and 1985. These funds and the commensurate program management responsibilities resided in 21 DOE program offices, each of which has its own mission and responsibilities. The Energy Materials Coordinating Committee (EMaCC) provides a formal mechanism to insure coordinated planning and maximum programmatic effectiveness for the Department's 374 million dollar per year materials effort. The EMaCC reports to the Director of the Office of Energy Research who in turn has oversight responsibilities for proper coordination of the technical programs of the Department. In carrying out this responsibility, EMaCC hosts meetings, organizes working groups, and publishes an annual technical report. This report is mandated by the EMaCC Terms of Reference. Its purpose is to disseminate information on the DOE materials programs for more effective coordination. It describes the materials research programs of various offices and divisions within the Department for FY 1984, contains funding information for FYs 1984 and 1985, and summarizes EMaCC activities for FY 1985

Activity report 1984

International Nuclear Information System (INIS)

Drent, W.

1985-07-01

For the fiscal year 1984, the technical activities of Eurochemic were: a) the cleaning of the vessels having contained medium level liquid wastes and the incorporation into bitumen of the resulting solution, b) the conditioning of plutonium contaminated solid waste, c) the civil engineering works of Building 29 were completed and the mounting of equipment was begun. The installation will assure the surface storage of the blocks resulting from vitrification, by means of Pamela installation of the high-level liquid wastes. The report includes administrative matters as well as health and safety activity. (AF)

Annual report 1984

International Nuclear Information System (INIS)

1985-01-01

This publication summarizes the activities of the Philippine Atomic Energy Commission (PAEC) for CY 1984. The regulatory responsibility of PAEC is further strengthened with the creation of a Board of Commissioners under Executive Order no. 980. Continuing studies are being conducted to support its regulatory function such as natural radioactivity measurements, behavior of tritium in different ecosystems and the determination of specific radionuclides in the Filipino biological system. A total of 47 R and D projects were undertaken. PAEC hosted three international meetings in the fields of Risk Assessment, Tissue Banking and Carabao Reproduction. (ELC)

1984-85 ISN progress report

International Nuclear Information System (INIS)

1985-01-01

This progress report ISN 1984-1985 deals with the following subjects: nuclear physics theory, peripheral and intermediate energy physics, characteristics of reaction mechanisms in heavy ion collisions, nuclear structure, fundamental interactions, experimental methods and new instrumentation, some interdisciplinary research activities and technical activities, the SARA cyclotron and finally, technology transfer and valorisation [fr

Contraceptive sterilization among Canadians, 1984-1995

Directory of Open Access Journals (Sweden)

Vijaya Krishnan

2004-12-01

Full Text Available Prior to early 1970s, traditional methods were the principal means of controlling the number and spacing of births. Today, an estimated 57 per cent of the world’s married women use contraceptives and half use modern methods such as medical sterilizations. Recent statistics suggest that Canada has the highest sterilization rate in the Western world. This paper presents findings of research examining sterilization trends in Canada with respect to changing patterns in the use of modern contraceptives, using data from the 1984 Canadian Fertility Survey (CFS and the 1995 General Social Survey (GSS. The main finding is that there is a decrease in the use of tubal ligation and an increase in the use of hysterectomy over the period 1984-1995. Less educated women are more likely to be in the forefront of modern methods of contraception.

Survey and alignment of HIRFL-CSR at IMP

International Nuclear Information System (INIS)

Man Kaidi; Guo Yizhen; Cai Guozhu; Yang Sengli; Wang Shoujin

2003-01-01

HIRFL-CSR (Heavy Ion Research Facility I Lanzhou- Cooler-Storage Ring project) is under construction in Institute of Modern Physics (IMP), Chinese Academy of Science, and will be completed in 2004. It is the post-acceleration system and consists of main ring (CSRm), experimental ring (CSRe) and radioactive beam line to connect the two rings. The circumference of CSRm and CSRe is 161.21 m and 128.96 m, respectively. The desired installation tolerances are obtained. In order to meet the stringent requirement, two stages control network was established. One is global (primary) network; the other is local (secondary) network. After optimization of the designed control network, the maximum error of point position is 0.046 mm. The origin of magnet component system is on its geometric center. According to the coordinate system, the fiducial is measured and the data will be saved in the database of survey. The application software has been developed. This program of DSCS (Database System for CDR Survey) is used for survey and alignment of CSR. We use SMX Laser Tracker 4500, LEICA TCA 2003 total station and NA3004 digital level. (Y. Tanaka)

Annual report 1984 Interfacultary Reactor Institute

International Nuclear Information System (INIS)

1985-01-01

In this annual report of the Dutch Interfacultary Reactor Institute, summary- and detailed reports are presented of current research during 1984 of the departments radiochemistry, radiation chemistry, radiation physics, reactor physics, and radiation hygiene and dosimetry. (H.W.). refs.; figs.; tabs

Solar-Geophysical Data Number 494, October 1985. Part 2 (comprehensive reports). Data for April 1985, January-June 1984, and miscellanea

International Nuclear Information System (INIS)

Coffey, H.E.

1985-10-01

Contents include: Detailed index for 1985; Data for April 1985 (Meudon carte synoptique, Solar radio bursts at fixed frequencies, Solar x-ray radiation from GOES satellite, Mass ejections from the sun, Active prominences and filaments); Data for January - June 1984--(Solar flares January 1984, Solar flares February 1984, Solar flares March 1984, Solar flares April 1984, Solar flares May 1984, Solar flares June 1984, Number of flares August 1966 - June 1984); Miscellaneous data--(Interplanetary solar wind July 1984-March 1985, Errata--Solar x-rays event list January 1985)

Use of 123I-IMP brain SPET to predict outcome following STA-MCA bypass surgery: cerebral blood flow but not vasoreactivity is a predictive parameter

International Nuclear Information System (INIS)

Kume, Norihiko; Hayashida, Kohei; Iwama, Toru; Cho, I.; Matsunaga, N.

1998-01-01

Superficial temporal artery - middle cerebral artery (STA-MCA) bypass surgery might improve the cerebral blood flow (CBF) but fail to reduce the risk of post-surgical events such as ischaemic stroke. In this study, we studied retrospectively whether the risk of post-surgical events corresponded to the change in resting CBF and/or the change in vasoreactivity observed before and after STA-MCA surgery using N-isopropyl-I-123-p-iodoamphetamine ( 123 I-IMP) brain single-photon emission tomography (SPET). 123 I-IMP brain SPET images obtained at rest and following acetazolamide challenge both before and after STA-MCA surgery were studied in 30 patients. Resting CBF was estimated semiquantitatively using the resting count ratios of the middle cerebral artery (MCA) area to the cerebellum. Acetazolamide challenge was assumed to result in an average increase in flow of 40% in the cerebellum. The vasoreactive response was then estimated as the ratio of the change in counts (acetazolamide - rest) to the resting cerebellar counts multiplied by 1.4. We classified 14 patients (50.5±19.3 years) into group I, who had a change in their resting CBF from before to after surgery of >10%, and 16 patients (54.0±18.8 years) into group II, who had a change in their resting CBF from before to after surgery of ≤10%. Oxygen-15 positron emission tomography (PET) studies were performed in five patients from group I and five patients from group II. One post-surgical event occurred in group I while there were eight post-surgical events in group II (P<0.05). Resting CBF improved by 20.4%±7.5% in group I and by 0.9%±6.9% in group II patients after surgery (P<0.001). No significant difference in the improvement in vasoreactivity was observed between group I patients (32.6%±17.7%) and group II patients (24.6%±15.6%) following surgery. Patients in the group I PET subset showed normalization of oxygen extraction fraction (OEF) from 0.59±0.09 before surgery to 0.46±0.06 after surgery (P<0

Youth Volunteering in the States: 2002 to 2006. Fact Sheet

Science.gov (United States)

Helms, Sara E.; Marcelo, Karlo Barrios

2007-01-01

Volunteer rates vary tremendously across states and age groups. In recent years, young people have exhibited rising volunteering rates, particularly high school students and college freshmen, but 2006 witnessed a drop in the volunteering rate among. When comparing the volunteer rates for different age groups from 2002 to 2006, 16-18 year olds…

Temperature profile and other data collected using CTD casts in the SE Pacific Ocean from NOAA Ship RESEARCHER from 1984-06-12 to 1984-06-30 (NODC Accession 8500249)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profile and other data were collected using CTD casts from NOAA Ship RESEARCHER in the SE Pacific Ocean from 12 June 1984 to 30 June 1984. Data were...

Comparison of IMP-SPECT findings to subtest scores of Wechsler intelligence adult Scale-Revised in temporal lobe epilepsy patients

Energy Technology Data Exchange (ETDEWEB)

Kan, Rumiko; Uejima, Masahiko; Kaneko, Yuko; Miyamoto, Yuriko; Watabe, Manabu; Takahashi, Ruriko; Niwa, Shin-ichi; Shishido, Fumio [Fukushima Medical Coll. (Japan)

1998-02-01

In this study, 40 temporal lobe epilepsy patients were assessed, using the Laterality Index (LI) of ROI values in IMP-SPECT findings, Wechsler adult intelligence Scale-Revised (WAIS-R) and subtest scores. LIs of the frontal, temporal and occipital lobes were calculated as follows: the ROI values on the right side were subtracted from those on the left, and the results was divided by the sum of the ROI values on the right and left sides. The individual subtest scores on WAIS-R were standardized by all evaluation scores in order to exclude the influence of differences in intelligence level as much as possible. The results were as follows: there was a positive correlation (r=0.74, p<0.001) between LI values and the performance in Arithmetic in the left temporal lobe hypoperfusion group. And there was a positive correlation (r=0.50, p<0.02) between LI values and the performance in Vocabulary in the left temporal lobe hypoperfusion group. In the right occipital lobe hypoperfusion group, there was a negative correlation (r=-O.44, p

Comparison of IMP-SPECT findings to subtest scores of Wechsler intelligence adult Scale-Revised in temporal lobe epilepsy patients

International Nuclear Information System (INIS)

Kan, Rumiko; Uejima, Masahiko; Kaneko, Yuko; Miyamoto, Yuriko; Watabe, Manabu; Takahashi, Ruriko; Niwa, Shin-ichi; Shishido, Fumio

1998-01-01

In this study, 40 temporal lobe epilepsy patients were assessed, using the Laterality Index (LI) of ROI values in IMP-SPECT findings, Wechsler adult intelligence Scale-Revised (WAIS-R) and subtest scores. LIs of the frontal, temporal and occipital lobes were calculated as follows: the ROI values on the right side were subtracted from those on the left, and the results was divided by the sum of the ROI values on the right and left sides. The individual subtest scores on WAIS-R were standardized by all evaluation scores in order to exclude the influence of differences in intelligence level as much as possible. The results were as follows: there was a positive correlation (r=0.74, p<0.001) between LI values and the performance in Arithmetic in the left temporal lobe hypoperfusion group. And there was a positive correlation (r=0.50, p<0.02) between LI values and the performance in Vocabulary in the left temporal lobe hypoperfusion group. In the right occipital lobe hypoperfusion group, there was a negative correlation (r=-O.44, p< O.05) between LI values and the performance in Coding. It is suggested that decreased blood flow areas detected by SPECT might influence brain function. (author)

Division of Biological and Medical Research research summary 1984-1985

Energy Technology Data Exchange (ETDEWEB)

Barr, S.H. (ed.)

1985-08-01

The Division of Biological and Medical Research at Argonne National Laboratory conducts multidisciplinary research aimed at defining the biological and medical hazards to man from energy technologies and new energy options. These technically oriented studies have a strong base in fundamental research in a variety of scientific disciplines, including molecular and cellular biology, biophysics, genetics, radiobiology, pharmacology, biochemistry, chemistry, environmental toxicology, and epidemiology. This research summary is organized into six parts. The first five parts reflect the Divisional structure and contain the scientific program chapters, which summarize the activities of the individual groups during the calendar year 1984 and the first half of 1985. To provide better continuity and perspective, previous work is sometimes briefly described. Although the summaries are short, efforts have been made to indicate the range of research activities for each group.

Division of Biological and Medical Research research summary 1984-1985

International Nuclear Information System (INIS)

Barr, S.H.

1985-08-01

The Division of Biological and Medical Research at Argonne National Laboratory conducts multidisciplinary research aimed at defining the biological and medical hazards to man from energy technologies and new energy options. These technically oriented studies have a strong base in fundamental research in a variety of scientific disciplines, including molecular and cellular biology, biophysics, genetics, radiobiology, pharmacology, biochemistry, chemistry, environmental toxicology, and epidemiology. This research summary is organized into six parts. The first five parts reflect the Divisional structure and contain the scientific program chapters, which summarize the activities of the individual groups during the calendar year 1984 and the first half of 1985. To provide better continuity and perspective, previous work is sometimes briefly described. Although the summaries are short, efforts have been made to indicate the range of research activities for each group

Parieto-occipital hypoaccumulation of 123I-IMP in the brain SPECT associated with maternal inheritance of diabetes mellitus

International Nuclear Information System (INIS)

Suzuki, Yoshihiko; Atsumi, Yoshihito; Hosokawa, Kazuhiro; Shimada, Akira; Asahina, Takayuki; Matsuoka, Kempei; Hata, Takashi; Taniyama, Matsuo.

1997-01-01

To determine the latent effect of diabetes inheritance on central nervous system, thirty diabetic patients were examined (14 male, 16 female). Seventeen patients had a mother with diabetes, and the other thirteen had non-diabetic mothers. They were previously determined to not have the 3243 mitochondrial tRNA mutation in peripheral leukocytes. Patients were tested for parieto-occipital hypoaccumulation of 123 I-IMP of brain SPECT, a characteristic neurofinding of mitochondrial diabetes mellitus due to the 3243 tRNA mutation. Seven (41.2%) out of 17 subjects with material inheritance had the parieto-occipital abnormality, whereas one (7.7%) out of 13 subjects with non-maternal inheritance had the abnormality. Seventeen (94.4%) out of 18 patients diabetes due to mitochondrial tRNA mutation at position 3243 showed the abnormality. Our results suggest that the material inheritance of diabetes is associated with the hypoaccumulation of 123 I-IMP of brain SPECT. We speculate that, because the patients with maternal inheritance might have subclinical mitochondrial dysfunction due to unknown mitochondrial DNA abnormalities, the mitochondrial DNA abnormality might cause their subclinical brain damage in the parieto-occipital area. (author)

Enova's industrial activities with results from 2006; Enovas industriaktiviteter med resultater fra 2006

Energy Technology Data Exchange (ETDEWEB)

2007-07-01

During 2006 Enova has been monitoring the energy consumption of the industries connected with Enova's group for industry. The industries activities, statistical numbers for energy consumption and bench-marketing number are included

Aenictus hoelldobleri sp. n., a new species of the Aenictus ceylonicus group (Hymenoptera, Formicidae from China, with a key to the Chinese members of the group

Directory of Open Access Journals (Sweden)

Michael Staab

2015-08-01

Full Text Available Aenictus is the most species-rich genus of army ants in the subfamily Dorylinae and one of the most species rich ant genera in China and the world. In this paper, a new species of the Aenictus ceylonicus group, Aenictus hoelldobleri sp. n., is described and illustrated based on the worker caste. The new species occurs in the subtropical forests of south-east China and is morphologically most similar to A. henanensis Li & Wang, 2005 and A. wudangshanensis Wang, 2006. Aenictus hoelldobleri sp. n. can be distinguished from both species by the shape of the subpetiolar process. The new species also resembles Aenictus lifuiae Terayama 1984 and A. thailandianus Terayama & Kubota, 1993 but clearly differs in various features of the cuticular sculpture. A key to the Chinese species of the A. ceylonicus group based on the worker caste is provided, which may help to reassess and clarify the taxonomic status of the abundant Chinese records of the true A. ceylonicus (Mayr, 1866, a species which almost certainly does not occur in China. Several new locality records are given, among them the first record of A. watanasiti Jaitrong & Yamane, 2013 from China.

Devenir un dieu. La mort d’Auguste et la naissance de la monarchie impériale

Directory of Open Access Journals (Sweden)

Frédéric HURLET

2015-03-01

Full Text Available Une des manifestations les plus remarquables de l’intelligence politique dont Auguste ?t preuve tout au long de sa vie fut d’avoir organisé dans les moindres détails ses propres funérailles. Il s’agissait d’éviter que se reproduisent à cette occasion les troubles qui avaient suivi la mort de son père adoptif Jules César le 15 mars 44 av. J.-C. et de garantir dans le même temps le succès de la première transmission dynastique du pouvoir impérial. Cet article étudie les enjeux politiques des événements des mois d’août et septembre 14 ap. J.-C. dans un ordre chronologique qui passe en revue les trois étapes suivantes : le décès d’Auguste proprement dit à travers les récits édi?ants qui lui ont été consacrés durant l’Antiquité ; le traitement de sa dépouille jusqu’au transfert de ses cendres dans son Mausolée ; sa divinisation. Le mythe d’Auguste est né en 14 ap. J.-C., au moment même où la continuité de la monarchie impériale était dé?nitivement assurée.

Radioactive materials released from nuclear power plants: Annual report, 1984

Energy Technology Data Exchange (ETDEWEB)

Tichler, J.; Norden, K.; Congemi, J.

1987-08-01

Releases of radioactive materials in airborne and liquid effluents from commercial light water reactors during 1984 have been compiled and reported. Data on solid waste shipments as well as selected operating information have been included. This report supplements earlier annual reports issued by the former Atomic Energy Commission and the Nuclear Regulatory Commission. The 1984 release data are summarized in tabular form. Data covering specific radionuclides are summarized.

A Profile of the U.S. Student Abroad--1984 and 1985.

Science.gov (United States)

Koester, Jolene

A survey of United States students studying and traveling abroad was conducted with a questionnaire distributed in the 1984 and 1985 applications for the International Student Identity Card. In 1984 all applications processed in New York were included in this study; in 1985 one out of every three applications was sampled. The total number of…

California School Accounting Manual. 1984 Edition.

Science.gov (United States)

Lundin, Janet, Ed.

California's official school accounting procedures, amended in 1984 to clarify definitions and improve program cost accounting, are presented. Following an introduction that discusses general characteristics of school accounting, the manual explains the following areas of accounting practice: (1) financial reporting; (2) income; (3) expenditures;…

Regional cerebral blood flow changes in schizophrenia and endogenous depression by single photon emission computed tomography (SPECT) using N-isopropyl-p-[123I]iodoamphetamine (IMP)

International Nuclear Information System (INIS)

Kanaya, Toshinori

1989-01-01

Regional cerebral blood flows (rCBF) were measured in patients with schizophrenia and endogenous depression by single photon emission computed tomography (SPECT) using N-isopropyl-p-[ 123 I]iodoamphetamine (IMP). The subjects were 20 patients with shizophrenia, 32 patients with endogenous depression and 20 normal controls. The patients with depression were divided into 3 groups; unmedicated, medicated patients in depressive state, and medicated patients in remited state. The rCBF were calculated by the corticocerebellar ratio (CCR), which was expressed as a ratio of activity per pixel in cortical regions of interest to the activity per pixel in the cerebellum. The results were as follows. In patients with schizophrenia the marked decrease in rCBF in bilateral frontal regions and the lower rCBF in the left than in the right hemisphere were observed. There was no significant correlation between the mean rCBF and BPRS (Brief Psychiatric Rating Scale) in patients with shizophrenia. In patients with depression the decrease in rCBF in overall cerebral regions and the lower rCBF in the left than in the right hemisphere were observed in both groups in depressive state. These changes were normalized in remited state, though there was no significant difference in rCBF between on medication and off medication. There was significantly negative correlation between the mean rCBF and Hamilton Depression Rating Scale in patients with depression. These results support the previously reported 'hypofrontality' and the left hemispheric dysfunction in shizophrenia. In depressive patients the overall cerebral dysfunction was revealed more remarkablly in the left than in the right hemisphere, which was normalized following the improvement of depressive symptoms. Furthermore, it was suggested that the applications of IMP-SPECT could be useful for the diagnosis and research for the cerebral function in mental illness. (author) 59 refs

Areva, reference document 2006

International Nuclear Information System (INIS)

2006-01-01

This reference document contains information on the AREVA group's objectives, prospects and development strategies, particularly in Chapters 4 and 7. It contains information on the markets, market shares and competitive position of the AREVA group. Content: - 1 Person responsible for the reference document and persons responsible for auditing the financial statements; - 2 Information pertaining to the transaction (Not applicable); - 3 General information on the company and its share capital: Information on AREVA, on share capital and voting rights, Investment certificate trading, Dividends, Organization chart of AREVA group companies, Equity interests, Shareholders' agreements; - 4 Information on company operations, new developments and future prospects: Overview and strategy of the AREVA group, The Nuclear Power and Transmission and Distribution markets, The energy businesses of the AREVA group, Front End division, Reactors and Services division, Back End division, Transmission and Distribution division, Major contracts, The principal sites of the AREVA group, AREVA's customers and suppliers, Sustainable Development and Continuous Improvement, Capital spending programs, Research and development programs, intellectual property and trademarks, Risk and insurance; - 5 Assets - Financial position - Financial performance: Analysis of and comments on the group's financial position and performance, 2006 Human Resources Report, Environmental Report, Consolidated financial statements, Notes to the consolidated financial statements, AREVA SA financial statements, Notes to the corporate financial statements; 6 - Corporate Governance: Composition and functioning of corporate bodies, Executive compensation, Profit-sharing plans, AREVA Values Charter, Annual Combined General Meeting of Shareholders of May 3, 2007; 7 - Recent developments and future prospects: Events subsequent to year-end closing for 2006, Outlook; 8 - Glossary; 9 - Table of concordance

Spectroscopie d'impédance électrochimique appliquée à l'étude de la corrosion

OpenAIRE

Gabrielli , Claude; Keddam , Michel; Takenouti , Hisasi

2007-01-01

Edition spéciale : 20e Forum sur les Impédances Electrochimiques / Special Edition: 20th Electrochemical Impedance Forum; International audience; Electrochemical Impedance spectroscopy applied to the corrosion study. Various applications of the Electrochemical Impedance Spectroscopy over the last 40 years are described. At the beginning of this long history, ac signal has been used simply to determine steady state entity, the polarisation resistance to apply Stern–Geary method. However, it wa...

Temperature profile and other data collected using CTD casts in the TOGA Area - Pacific Ocean from NOAA Ship RESEARCHER from 1984-04-09 to 1984-11-05 (NODC Accession 8800072)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profile and other data were collected using CTD casts from NOAA Ship RESEARCHER in the TOGA Area - Pacific Ocean from 09 April 1984 to 05 November 1984....

Areva half-year report june 30, 2006

International Nuclear Information System (INIS)

2006-01-01

This document is the half-year financial report of the Areva group for 2006. It presents: 1 - Highlights of the period; 2 - Key data: Summary data, Segment reporting, Backlog, Income statement, Review by business division, Cash flow, Balance sheet data; 3 - Outlook; 4 - Events subsequent to the half-year end; 5 - Consolidated financial statements: Statutory auditors' report on the interim consolidated financial statements for the period January 1, 2006 to June 30, 2006, Consolidated income statement, Consolidated balance sheet, Consolidated cash flow statement, Consolidated statement of changes in equity, Segment reporting, Notes to the consolidated financial statements

University of Arizona TRIGA reactor. Annual utilization report, 1984-1985

International Nuclear Information System (INIS)

Nelson, G.W.

1986-01-01

This is the annual report for the University of Arizona TRIGA Reactor under Contract No. DE-AC02-76ER02096 covering the period July 1, 1984 through June 30, 1985, including the 1984-85 Academic Year. The purpose of this report is to document the facility usage which is possible because of DOE support under the contract. The reactor is operated under License R-52 with the United States Nuclear Regulatory Commission

Temperature profile data collected using BT and XBT casts in the TOGA Area - Pacific Ocean from NOAA Ship RESEARCHER from 1984-06-09 to 1984-06-21 (NODC Accession 8700051)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profile data were collected using XBT and BT casts from NOAA Ship RESEARCHER in the TOGA Area - Pacific Ocean from 09 June 1984 to 21 June 1984. Data...

Temperature profile data collected using BT and XBT casts from NOAA Ship RESEARCHER in the TOGA Area- Pacific Ocean from 1984-04-11 to 1984-05-05 (NODC Accession 8800211)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profile data were collected using XBT and BT casts from NOAA Ship RESEARCHER in the TOGA Area - Pacific Ocean from 11 April 1984 to 05 May 1984. Data...

Planned and unplanned home births and hospital births in Calgary, Alberta, 1984-87.

OpenAIRE

Abernathy, T J; Lentjes, D M

1989-01-01

Information collected on all home births in Calgary (Canada) between the years 1984 and 1987, was examined and analyzed according to whether the home birth environment had been planned or unplanned. The two groups were compared to each other and to all hospital births according to demographic characteristics of mothers, indicators of prenatal care, and birth outcome. Mothers who had planned their home birth were more likely to be primiparous, attend prenatal classes, obtain regular prenatal c...

Usefulness of quantitative determination of cerebral blood flow by 123I-IMP SPECT reference sample method in various cerebrovascular disorders

International Nuclear Information System (INIS)

Fukuda, Tadaharu; Hasegawa, Kouichi; Yamanaka, Shigehito; Hasue, Masamichi; Ohtubo, Yutaka; Wada, Atsushi; Nakanishi, Hisashi; Nakamura, Tatuya; Itou, Hiroshi.

1992-01-01

Cerebral blood flow (CBF) was quantitatively determined by N-isopropyl-p-[ 123 I] iodo-amphetamine (IMP) single photon emission computed tomography (SPECT) with a rotating gamma camera. A ZLC 7500 unit (SIEMENS Inc.) was used for emission CT, and a SCINTIPAK-2400 (Shimadzu Corp. Ltd.) for data processing. For the quantitative determination of CBF, arterial blood samples were collected for 5 minutes during the intravenous injection of 111 MBq of IMP, and a reference sample method corrected by time-activity curve was used. The determination was carried out in 90 patients with various cerebrovascular diseases and 5 normal volunteers. Mean cerebral blood flow (m-CBF) in the normal cases as determined by the above method was 42.4±6.0 (ml/100g/min). In patients with acute phase subarachnoid hemorrhage (SAH), severity on CT was marked in patients with intracerebral hematomas greater than 45 mm in diameter. Patients with non-hemorrhagic arteriovenous malfomation (AVM) whose nidi were 30 mm or more in diameter showed a decrease in CBF on the afferent side. This decrease was caused by a steal phenomenon affecting CBF around the AVM. The size of cerebral infarction on CT was closely correlated with the decrease in CBF, and CBF in patients with stenosis and obstruction of the main trunks was less than that in patients without them. CBF was increased by 10-20% in patients who underwent carotid endarterectomy or superior temporal artery-middle cerebral artery anastomosis for obstruction or stenosis of the internal carotid artery or the middle cerebral artery. The quantitative determination of CBF by IMP SPECT reference sample method was useful for evaluating the morbid condition and estimating the prognosis of cerebrovascular diseases, and evaluating the effects of therapy. (J.P.N.)

Analysis of regional cerebral blood flow and distribution volume in Machado-Joseph disease by iodine-{sup 123}I IMP single photon emission computed tomography

Energy Technology Data Exchange (ETDEWEB)

Hayashi, Tsunemi; Nakajima, Takashi; Fukuhara, Nobuyoshi [National Saigata Hospital, Ohagata, Niigata (Japan)

2001-09-01

Machado-Joseph disease (MJD) is an autosomal dominant spinocerebellar ataxia. Its clinical features vary greatly in different generations of the same family. Regional cerebral blood flow (rCBF) and distribution volume (V{sub d}) in the pons, cerebellum, and cerebral cortex were measured in 12 patients with MJD by autoradiography (ARG) and the table look-up (TLU) method of iodine-123 IMP ({sup 123}I-IMP) single photon emission computed tomography (SPECT). Representative cases were as follows: A 46-year-old woman first experienced gait ataxia at age 38. Computed tomography (CT) and magnetic resonance imaging (MRI) showed no atrophy in the pons or cerebellum, but rCBF measured by the {sup 123}I-IMP SPECT ARG method detected hypoperfusion in the pons, and cerebellar vermis and hemisphere. A 76-year-old woman first experienced gait ataxia at age 69. CT and MRI findings showed severe atrophy in the pons, and cerebellar vermis and hemisphere. Moreover, rCBF was decreased in the pons, whereas it was not decreased in the cerebellar vermis and hemisphere. In the pons of patients with MJD, rCBF was markedly decreased regardless of disease severity. Because this SPECT finding for the pons looked like a 'dot', we have called it the 'pontine dot sign'. In the MJD group, rCBF was significantly decreased in the pons (Student's t test, p<0.01) and cerebellar vermis (p<0.05). The V{sub d} was also significantly decreased in the pons (p<0.005) in comparison with that for normal subjects. Pearson's correlation analysis yielded a significant relationship between the rCBF in the pons and age at onset (r=0.578, p<0.05). There was a strong correlation between the V{sub d} for the pons and age at onset (r=0.59, p<0.05). Person's correlation analysis also showed a significant relationship between the V{sub d} in the cerebellar hemispheres and International Cooperative Ataxia Rating Scale (r=0.644, p<0.05). The pontine rCBFs in patients with early onset MJD

Labeling of - N-Isopropil - p - I-Anphetamine (IMP-131I) and its biological distribution in rats

International Nuclear Information System (INIS)

Barboza, M.F. de; Goncalves, R.S.V.; Muramoto, E.

1988-09-01

The described labeling and purification preparation of N-Isopropil-p 131 I-anphetamine ( 131 I-IMP) represents a fast and efficient method to obtains a compound that fullfills all criterions of purity for its application 'IN VIVO'. The labeling yield was 68-78% and the radiochemical purity performed by paper chromatography and electrophorese was 97-99%. As demostrated in animal experiments, the cerebral affinity offers a possibility to study brain diseases in clinical studies when the product will be labelled with 123 I. (author) [pt

Annual report 1984

International Nuclear Information System (INIS)

1985-02-01

This report summarizes some of the results of the space physics research carried out at Kiruna Geophysical Institute (except at Uppsala Ionospheric Observatory which reports separately) during 1984. The research programme includes experimental work using ground based instruments, e.g. EISCAT and optical instruments, and instruments carried on sounding rockets and satellites. The experimental projects are supported by theoretical investigations. The following five titles summarize the major fields of investigation: 1 Acceleration mechanisms for auroral particles; 2 Magnetospheric wave-particle interactions as observed primarily in the particle populations; 3 Composition measurements in the hot magnetospheric plasma; 4 Convection electric field effects on magnetospheric particle populations; 5 EISCAT related research. (author)

Parieto-occipital hypoaccumulation of {sup 123}I-IMP in the brain SPECT associated with maternal inheritance of diabetes mellitus

Energy Technology Data Exchange (ETDEWEB)

Suzuki, Yoshihiko; Atsumi, Yoshihito; Hosokawa, Kazuhiro; Shimada, Akira; Asahina, Takayuki; Matsuoka, Kempei [Saiseikai Central Hospital, Tokyo (Japan); Hata, Takashi; Taniyama, Matsuo

1997-07-01

To determine the latent effect of diabetes inheritance on central nervous system, thirty diabetic patients were examined (14 male, 16 female). Seventeen patients had a mother with diabetes, and the other thirteen had non-diabetic mothers. They were previously determined to not have the 3243 mitochondrial tRNA mutation in peripheral leukocytes. Patients were tested for parieto-occipital hypoaccumulation of {sup 123}I-IMP of brain SPECT, a characteristic neurofinding of mitochondrial diabetes mellitus due to the 3243 tRNA mutation. Seven (41.2%) out of 17 subjects with material inheritance had the parieto-occipital abnormality, whereas one (7.7%) out of 13 subjects with non-maternal inheritance had the abnormality. Seventeen (94.4%) out of 18 patients diabetes due to mitochondrial tRNA mutation at position 3243 showed the abnormality. Our results suggest that the material inheritance of diabetes is associated with the hypoaccumulation of {sup 123}I-IMP of brain SPECT. We speculate that, because the patients with maternal inheritance might have subclinical mitochondrial dysfunction due to unknown mitochondrial DNA abnormalities, the mitochondrial DNA abnormality might cause their subclinical brain damage in the parieto-occipital area. (author)

Regional cerebral blood flow changes in schizophrenia and endogenous depression by single photon emission computed tomography (SPECT) using N-isopropyl-p-( sup 123 I)iodoamphetamine (IMP)

Energy Technology Data Exchange (ETDEWEB)

Kanaya, Toshinori (Hiroshima Univ. (Japan). School of Medicine)

1989-06-01

Regional cerebral blood flows (rCBF) were measured in patients with schizophrenia and endogenous depression by single photon emission computed tomography (SPECT) using N-isopropyl-p-({sup 123}I)iodoamphetamine (IMP). The subjects were 20 patients with shizophrenia, 32 patients with endogenous depression and 20 normal controls. The patients with depression were divided into 3 groups; unmedicated, medicated patients in depressive state, and medicated patients in remited state. The rCBF were calculated by the corticocerebellar ratio (CCR), which was expressed as a ratio of activity per pixel in cortical regions of interest to the activity per pixel in the cerebellum. The results were as follows. In patients with schizophrenia the marked decrease in rCBF in bilateral frontal regions and the lower rCBF in the left than in the right hemisphere were observed. There was no significant correlation between the mean rCBF and BPRS (Brief Psychiatric Rating Scale) in patients with shizophrenia. In patients with depression the decrease in rCBF in overall cerebral regions and the lower rCBF in the left than in the right hemisphere were observed in both groups in depressive state. These changes were normalized in remited state, though there was no significant difference in rCBF between on medication and off medication. There was significantly negative correlation between the mean rCBF and Hamilton Depression Rating Scale in patients with depression. These results support the previously reported 'hypofrontality' and the left hemispheric dysfunction in shizophrenia. In depressive patients the overall cerebral dysfunction was revealed more remarkablly in the left than in the right hemisphere, which was normalized following the improvement of depressive symptoms. Furthermore, it was suggested that the applications of IMP-SPECT could be useful for the diagnosis and research for the cerebral function in mental illness. (author) 59 refs.

Alterations in macroinvertebrate spatial patterns in coastal lagoons: Óbidos (NW coast of Portugal) 1984 versus 2002

Science.gov (United States)

Rodrigues, Ana Maria; Quintino, Victor; Pereira, Fábio; Freitas, Rosa

2012-09-01

The macroinvertebrate spatial distribution patterns in the Lagoon of Óbidos were studied in 1984 and revisited in 2002. The overall surficial sediments and benthic community patterns show consistent similarities in the two sampling periods, but also important differences. The lagoon is relatively shallow, with about 1/3 of the area covered with extensive intertidal sand banks. These are interrupted by a navigation channel bordering the northern margin (1984) and, following dredging operations, a new navigation channel was opened along the southern margin (2002). The sediments in the navigation channels were coarser and with less percentage of fines in 2002 than in 1984. Arthropods dominated the species richness and abundance in 1984, but were much less important in 2002, when the community was dominated by molluscs and annelids, both in species numbers as well as in abundance. In 1984, the structure of the macrofauna communities closely followed a general model proposed for Atlantic and Mediterranean lagoons, with the marine, the transition and the lagoon communities occupying very well defined areas. This gradient was in accordance with an increase in the fines and organic matter content directed inwards allowing for the coexistence of several characteristic lagoon species with others characteristic of organic enriched sediments. In 2002 this spatial pattern is still recognized but the marine and the transition communities are spatially mixed, occupying both the entrance region and the navigation channels, whereas the characteristic lagoon community identified in 1984 was only recognized in a group of sites located along the southern margin in 2002. Several species show very important changes in their distribution extent in the lagoon system. These changes essentially show a generalized inward expansion of the distribution range of the marine species, in agreement with a larger influence of marine conditions toward the inner areas of the lagoon. This study shows

Astronautics and Aeronautics, 1979-1984: A chronology

Science.gov (United States)

Janson, Bette R.; Ritchie, Eleanor H.

1989-01-01

This volume of the Astronautics and Aeronautics series covers 1979 through 1984. The series provides a chronological presentation of all significant events and developments in space exploration and the administration of the space program during the period covered.

2006 Rare Neuroimmunological Disorders Symposium; Sheraton Inner Harbor, Baltimore, MD, July 20-23, 2006

DEFF Research Database (Denmark)

Kerr, DA; Antel, JP; Arnold, DL

2007-01-01

On July 20-22nd 2006, the second International Rare Neuroimmunologic Disorders Symposium was held in Baltimore, Maryland. The purpose of this symposium was to bring together diverse groups interested in immune-mediated disorders of the nervous system. The symposium was not disease-specific but at...

Current meter and other data from current meter casts from NOAA Ship RESEARCHER in the North and South Pacific Ocean from 1984-06-28 to 1984-07-01 (NODC Accession 8500226)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Current meter and other data were collected using current meter casts from NOAA Ship RESEARCHER in the North/South Pacific Ocean from June 28, 1984 to July 1, 1984....

IMAGE-2006 Mosaic: Product Description

OpenAIRE

SOILLE Pierre; BIELSKI Conrad

2008-01-01

This report describes the IMAGE-2006 mosaic products. Each product consists of a range of information layers grouped into three categories: base layers, mosaic layers, and quality layers. A mosaic product is available for each coverage and data/country region of interest combination.

Environmental surveillance at Los Alamos during 1984

International Nuclear Information System (INIS)

1985-04-01

This report describes the environmental surveillance program conducted by the Los Alamos National Laboratory during 1984. Routine monitoring for radiation and radioactive or chemical substances is conducted on the Laboratory site and in the surrounding region to determine compliance with appropriate standards and permit early identification of possible undesirable trends. Results and interpretation of data for 1984 are included on external penetrating radiation; on the chemical and radiochemical quality of ambient air, surface and ground waters, municipal water supply, soils and sediments, and foodstuffs; and on the quantities of airborne emissions and liquid effluents. Comparisons with appropriate standards, regulations, and background levels from natural or other non-Laboratory sources provide a basis for concluding that environmental effects attributable to Laboratory operations are insignificant and are not considered hazardous to the population of the area or Laboratory employees. 8 refs., 38 figs., 57 tabs

Purine 3':5'-cyclic nucleotides with the nucleobase in a syn orientation: cAMP, cGMP and cIMP.

Science.gov (United States)

Řlepokura, Katarzyna Anna

2016-06-01

Purine 3':5'-cyclic nucleotides are very well known for their role as the secondary messengers in hormone action and cellular signal transduction. Nonetheless, their solid-state conformational details still require investigation. Five crystals containing purine 3':5'-cyclic nucleotides have been obtained and structurally characterized, namely adenosine 3':5'-cyclic phosphate dihydrate, C10H12N5O6P·2H2O or cAMP·2H2O, (I), adenosine 3':5'-cyclic phosphate 0.3-hydrate, C10H12N5O6P·0.3H2O or cAMP·0.3H2O, (II), guanosine 3':5'-cyclic phosphate pentahydrate, C10H12N5O7P·5H2O or cGMP·5H2O, (III), sodium guanosine 3':5'-cyclic phosphate tetrahydrate, Na(+)·C10H11N5O7P(-)·4H2O or Na(cGMP)·4H2O, (IV), and sodium inosine 3':5'-cyclic phosphate tetrahydrate, Na(+)·C10H10N4O7P(-)·4H2O or Na(cIMP)·4H2O, (V). Most of the cyclic nucleotide zwitterions/anions [two from four cAMP present in total in (I) and (II), cGMP in (III), cGMP(-) in (IV) and cIMP(-) in (V)] are syn conformers about the N-glycosidic bond, and this nucleobase arrangement is accompanied by Crib-H...Npur hydrogen bonds (rib = ribose and pur = purine). The base orientation is tuned by the ribose pucker. An analysis of data obtained from the Cambridge Structural Database made in the context of syn-anti conformational preferences has revealed that among the syn conformers of various purine nucleotides, cyclic nucleotides and dinucleotides predominate significantly. The interactions stabilizing the syn conformation have been indicated. The inter-nucleotide contacts in (I)-(V) have been systematized in terms of the chemical groups involved. All five structures display three-dimensional hydrogen-bonded networks.

Gaz de France 2006 annual report

International Nuclear Information System (INIS)

2006-01-01

Gaz de France is major European energy utility, which produces, purchases, transports, distributes and sells natural gas, electricity and related services for its residential, corporate and local government customers. Its strategic focuses are to develop an ambitious marketing strategy, pursue a supply and procurement policy that guarantees the Group's competitiveness, confirm its position as a benchmark infrastructure manager, and speed up its profitable growth in Europe. Gaz de France aligns its strategy with a concrete and ambitious sustainable development policy. Its growth model is based on responsiveness to customers and constructive dialogue with its employees and partners. This document is the activity report of the group for the year 2006. It presents: 1 - the corporate profile of the group; 2 - its strategies (energy, energy supply, infrastructures); 3 - its financial highlights; 4 - its governance, shareholders and human resources; 5 - the activities of the group (exploration and production, energy procurement, energy sales, services, transmission France, storage France, LNG terminals, distribution France, transmission and distribution international, research and development); 6 - its 2006 financial data and financial summary

Carbon trends. July 2006; Tendances carbone. Juillet 2006

Energy Technology Data Exchange (ETDEWEB)

NONE

2006-07-15

This newsletter makes a monthly synthesis of the European CO{sub 2} market: traded volumes, spot prices, conformability of facilities, supply and demand, climate indexes (temperature, precipitations from June 2005 to June 2006), economic activity indicators (industrial production index from April 2005 to April 2006), confidence index of business leaders (from June 2005 to June 2006), changes in energy prices (from July 2005 to June 2006), CO{sub 2} quotas allocated to European Union countries and detailed indicators of CO{sub 2} market, climate, economic activity and energy prices. (J.S.)

Carbon trends. May 2006; Tendances carbone. Mai 2006

Energy Technology Data Exchange (ETDEWEB)

NONE

2006-05-15

This newsletter makes a monthly synthesis of the European CO{sub 2} market: traded volumes, spot prices, conformability of facilities, supply and demand, climate indexes (temperature, precipitations from May 2005 to April 2006), economic activity indicators (industrial production from February 2005 to February 2006), confidence index of business leaders (from April 2005 to April 2006), changes in energy prices (from May 2005 to April 2006), CO{sub 2} quotas allocated to European Union countries and detailed indicators of CO{sub 2} market, climate, economic activity and energy prices. (J.S.)

Carbon trends. June 2006; Tendances carbone. Juin 2006

Energy Technology Data Exchange (ETDEWEB)

NONE

2006-06-15

This newsletter makes a monthly synthesis of the European CO{sub 2} market: traded volumes, spot prices, conformability of facilities, supply and demand, climate indexes (temperature, precipitations from June 2005 to May 2006), economic activity indicators (industrial production from March 2005 to March 2006), confidence index of business leaders (from May 2005 to May 2006), changes in energy prices (from June 2005 to May 2006), CO{sub 2} quotas allocated to European Union countries and detailed indicators of CO{sub 2} market, climate, economic activity and energy prices. (J.S.)

Nucor review 1984-1985

International Nuclear Information System (INIS)

1985-01-01

This report discusses the activities of the Nuclear Development Corporation of South Africa (Pty) Ltd. (NUCOR) for the period 1 April 1984 to 31 March 1985. The commissioning and raising to power of Koeberg's Unit 1 was completed and the plant taken over in July 1984. On 21 January 1985 it was shut down for an in-service inspection. Development at the Gouriqua Nuclear research site and the Vaalputs waste disposal site proceeded. The Geology department is responsible for establishing the extent and nature of uranium deposits in South Africa and for compiling statistics in this connection. Work in connection with uranium extraction was continued by MINTEK. The Chemistry department is responsible for developing new and improved analytical techniques for the location of uranium. Radiometric analyses of uranium ores are carried out. The Uranium Enrichment Corporation is responsible for all development and production aspects of uranium enrichment. The ELPROD-plant is used for the manufacturing of fuel elements. NUCOR concentrates on actively encouraging the use of radioisotopes and radiation in specific applications in industry, medicine, agriculture and research. Further success was achieved with the irradiation of bananas and strawberries. Modest attention was again paid to several projects of a fundamental nature. These projects relate to nuclear physics, theoretical physics, plasma physics, radiation physics, health physics, solid-state physics, nuclear chemistry, radiation chemistry and life sciences. The demand for the development, construction and maintenance of electronic systems also continued

The ETA-II linear induction accelerator and IMP wiggler: A high-average-power millimeter-wave free-electron-laser for plasma heating

International Nuclear Information System (INIS)

Allen, S.L.; Scharlemann, E.T.

1992-05-01

We have constructed a 140-GHz free-electron laser to generate high-average-power microwaves for heating the MTX tokamak plasma. A 5.5-m steady-state wiggler (intense Microwave Prototype-IMP) has been installed at the end of the upgraded 60-cell ETA-II accelerator, and is configured as an FEL amplifier for the output of a 140-GHz long-pulse gyrotron. Improvements in the ETA-II accelerator include a multicable-feed power distribution network, better magnetic alignment using a stretched-wire alignment technique (SWAT). and a computerized tuning algorithm that directly minimizes the transverse sweep (corkscrew motion) of the electron beam. The upgrades were first tested on the 20-cell, 3-MeV front end of ETA-II and resulted in greatly improved energy flatness and reduced corkscrew motion. The upgrades were then incorporated into the full 60-cell configuration of ETA-II, along with modifications to allow operation in 50-pulse bursts at pulse repetition frequencies up to 5 kHz. The pulse power modifications were developed and tested on the High Average Power Test Stand (HAPTS), and have significantly reduced the voltage and timing jitter of the MAG 1D magnetic pulse compressors. The 2-3 kA. 6-7 MeV beam from ETA-II is transported to the IMP wiggler, which has been reconfigured as a laced wiggler, with both permanent magnets and electromagnets, for high magnetic field operation. Tapering of the wiggler magnetic field is completely computer controlled and can be optimized based on the output power. The microwaves from the FEL are transmitted to the MTX tokamak by a windowless quasi-optical microwave transmission system. Experiments at MTX are focused on studies of electron-cyclotron-resonance heating (ECRH) of the plasma. We summarize here the accelerator and pulse power modifications, and describe the status of ETA-II, IMP, and MTX operations

The ETA-II linear induction accelerator and IMP wiggler: A high-average-power millimeter-wave free-electron laser for plasma heating

International Nuclear Information System (INIS)

Allen, S.L.; Scharlemann, E.T.

1993-01-01

The authors have constructed a 140-GHz free-electron laser to generate high-average-power microwaves for heating the MTX tokamak plasma. A 5.5-m steady-state wiggler (Intense Microwave, Prototype-IMP) has been installed at the end of the upgraded 60-cell ETA-II accelerator, and is configured as an FEL amplifier for the output of a 140-GHz long-pulse gyrotron. Improvements in the ETA-II accelerator include a multicable-feed power distribution network, better magnetic alignment using a stretched-wire alignment technique (SWAT), and a computerized tuning algorithm that directly minimizes the transverse sweep (corkscrew motion) of the electron beam. The upgrades were first tested on the 20-cell, 3-MeV front end of ETA-II and resulted in greatly improved energy flatness and reduced corkscrew motion. The upgrades were then incorporated into the full 60-cell configuration of ETA-II, along with modifications to allow operation in 50-pulse bursts at pulse repetition frequencies up to 5 kHz. The pulse power modifications were developed and tested on the High Average Power Test Stand (HAPTS), and have significantly reduced the voltage and timing jitter of the MAG 1D magnetic pulse compressors. The 2-3 kA, 6-7 MeV beam from ETA-II is transported to the IMP wiggler, which has been reconfigured as a laced wiggler, with both permanent magnets and electromagnets, for high magnetic field operation. Tapering of the wiggler magnetic field is completely computer controlled and can be optimized based on the output power. The microwaves from the FEL are transmitted to the MTX tokamak by a windowless quasi-optical microwave transmission system. Experiments at MTX are focused on studies of electron-cyclotron-resonance heating (ECRH) of the plasma. The authors summarize here the accelerator and pulse power modifications, and describe the status of ETA-II, IMP, and MTX operations

Regional cerebral blood flow in Parkinson's disease by [sup 123]I-IMP SPECT

Energy Technology Data Exchange (ETDEWEB)

Kitamura, Yoshihiro [Okayama Univ. (Japan). School of Medicine

1994-06-01

Regional cerebral blood flow (rCBF) was evaluated in 63 patients with Parkinson's disease (PD) by single-photon emission computed tomography (SPECT) using N-isopropyl-p-[sup 123]I-iodoamphetamine ([sup 123]I-IMP) as a tracer. Evaluation of the SPECT images was performed in accordance with the rCBF quantification method using a microsphere model. Patients in stage IV demonstrated significantly lower rCBF than those in stage II at the frontal, temporal, parietal, occipital regions and in the thalamus and cerebellum. Subjects with mental symptoms demonstrated decreased rCBF in every region in the brain. The present study indicates that clinical exacerbation and manifestation of dementia and other psychiatric symptoms in Parkinson's disease are associated with decreased blood flow in various brain regions. (author).

Report on 1984 research result on the R and D of observation system for probing resources. 1/2; 1984 nendo shigen tansayo kansoku system no kenkyu kaihatsu. 1/2

Energy Technology Data Exchange (ETDEWEB)

NONE

1985-03-01

The 'space development policy outline' of Japan was reexamined in February, 1984, which decided on promoting the earth resources satellite (ERS-1) project. Accordingly, the Government Research Institute decided to implement the 'observation system for probing resources' from fiscal 1984. On January 18, 1985, a technological association for resource remote-sensing system was established and entrusted with the 'R and D of observation system for probing resources' from the Institute. This paper is the summary of the research results submitted as the 'report on the results of 1984 assigned research'. The report outlines, first as the 'introduction', the purpose of the establishment of the research association, details of the establishment, organization of the association, development system, development schedule, etc., and summarized, second as the 'general remarks', the explanation of the results of the 1984 assigned research. This explanation included the objectives of the research, the state of the implementation of the research, and the results of the research, for example. The paper contained, thirdly as the 'itemized explanation', the details of the individual explanation of the result for each assigned research subject. (NEDO)

Waste Area Group 10, Operable Unit 10-08, Remedial Investigation/Feasibility Study Annual Status Report for Fiscal Year 2006

Energy Technology Data Exchange (ETDEWEB)

R. P. Wells

2007-05-09

This report provides a status of the progress made in Fiscal Year 2006 on tasks identified in the Waste Area Group 10, Operable Unit 10-08, Remedial Investigation/Feasibility Study Work Plan. Major accomplishments include: (1) groundwater sampling and review of the groundwater monitoring data, (2) installation of a Sitewide groundwater-level monitoring network, (3) update of the Groundwater Monitoring and Field Sampling Plan of Operable Unit 10-08, (4) re-evaluation of the risk at Site TSF-08, (5) progress on the Operable Unit 10-08 Sitewide Groundwater Model.

Hazards Control Department annual technology review, 1984

International Nuclear Information System (INIS)

Griffith, R.V.; Anderson, K.J.

1985-01-01

The Annual Technology Review covers the period from October 1983 to September 1984. Topics reviewed include Nuclear Criticality Information System, nuclear dosimetry, personnel dosimetry, laser chemistry, electric filters and neutron spectrometry. Individual papers are indexed and abstracted for the data base. (DT)

Analytical Chemistry Laboratory progress report for FY 1984

International Nuclear Information System (INIS)

Green, D.W.; Heinrich, R.R.; Jensen, K.J.; Stetter, J.R.

1985-03-01

Technical and administrative activities of the Analytical Chemistry Laboratory (ACL) are reported for fiscal year 1984. The ACL is a full-cost-recovery service center, with the primary mission of providing a broad range of technical support services to the scientific and engineering programs at ANL. In addition, ACL conducts a research program in analytical chemistry, works on instrumental and methods development, and provides analytical services for governmental, educational, and industrial organizations. The ACL is administratively within the Chemical Technology Division, the principal user, but provides technical support for all of the technical divisions and programs at ANL. The ACL has three technical groups - Chemical Analysis, Instrumental Analysis, and Organic Analysis. Under technical activities 26 projects are briefly described. Under professional activities, a list is presented for publications and reports, oral presentations, awards and meetings attended. 6 figs., 2 tabs

Work-related agricultural fatalities in Australia, 1982-1984.

Science.gov (United States)

Erlich, S M; Driscoll, T R; Harrison, J E; Frommer, M S; Leigh, J

1993-06-01

Work-related agricultural fatalities were examined as part of a larger population-based study of all work-related fatalities in Australia in the period 1982-1984. A total of 257 farm-related fatalities were identified, of which 223 were deaths of persons in the employed civilian labor force (19.4 deaths per 100,000 persons per year) and 34 were deaths of children less than 15 years of age. The fatality incidence was higher among men, older age groups, and nonmanagers in general and in certain occupations in particular. Mobile mechanical equipment (particularly tractors) was the main fatal agent, roll-overs accounting for many of the fatalities. Better provision of information to agricultural workers, improvements in compliance to and enforcement of legislation, and changes in farming work practices are recommended to improve the safety of farms and farm work.

Trends in rates of natural conceptions among Danish women born during 1960-1984

DEFF Research Database (Denmark)

Lassen, Tina Harmer; Sobotka, Tomás; Jensen, Tina Kold

2012-01-01

born in 1960 to 2.15 among women born in 1984, with stable values of 2.15-2.16 projected in the youngest cohorts analysed, 1979-1984. The projected decline was a consequence of a decrease in induced abortion rates and an increase in the use of ART among the younger cohorts. Furthermore, we projected...... not be included, which led to underestimation of the frequency of births after ART treatment.WIDER IMPLICATIONS OF THE FINDINGSThe results of our study contribute new insights to the research field of declining fertility rates in Europe and many other parts of the world.STUDY FUNDING/COMPETING INTERESTSThis study......STUDY QUESTIONThe aim of the study was to analyse trends in the rate of natural conceptions (RNC) among birth cohorts of women born during the period 1960-1984.SUMMARY ANSWERIn this nationwide study of Danish-born female cohorts born during the period 1960-1984, we found a gradual decline...

Cloning and characterization of the gene encoding IMP dehydrogenase from Arabidopsis thaliana.

Science.gov (United States)

Collart, F R; Osipiuk, J; Trent, J; Olsen, G J; Huberman, E

1996-10-03

We have cloned and characterized the gene encoding inosine monophosphate dehydrogenase (IMPDH) from Arabidopsis thaliana (At). The transcription unit of the At gene spans approximately 1900 bp and specifies a protein of 503 amino acids with a calculated relative molecular mass (M(r)) of 54,190. The gene is comprised of a minimum of four introns and five exons with all donor and acceptor splice sequences conforming to previously proposed consensus sequences. The deduced IMPDH amino-acid sequence from At shows a remarkable similarity to other eukaryotic IMPDH sequences, with a 48% identity to human Type II enzyme. Allowing for conservative substitutions, the enzyme is 69% similar to human Type II IMPDH. The putative active-site sequence of At IMPDH conforms to the IMP dehydrogenase/guanosine monophosphate reductase motif and contains an essential active-site cysteine residue.

Cerebral blood flow single-photon emission tomography with 123I-IMP in vascular dementia

International Nuclear Information System (INIS)

Kawahata, Nobuya; Gotoh, Chiharu; Yokoyama, Sakura; Daitoh, Nobuyuki

2001-01-01

Cerebral blood flow differences between patients with vascular dementia, patients with multiple lacunar infarction without cognitive dysfunction, and age-matched controls were examined. Thirty four patients with vascular dementia (VD) were selected from consecutive referrals to the Memory Clinic at Narita Memorial Hospital. All the patients had routine assessment including history, physical and neurological examinations, neuropsychological assessment, blood tests, EEG, head MRI, and single photon emission computed tomography (SPECT). All of them fulfilled the NINDS-AIREN diagnostic criteria for vascular dementia. Thirty nine patients with multiple lacunar infarction without cognitive dysfunction and 110 age-matched controls were included in this study. Mean cerebral blood flow (mCBF) and regional cerebral blood flow (rCBF) were measured using N-isopropyl-P- 123 I-iodoamphetamine ( 123 I-IMP) and SPECT imager. The mCBF in VD was 27.6±5.3 ml/100 g/min, while those in the control group and multiple lacunar infarction without cognitive dysfunction were 36.6±6.1 ml/100 g/min and 32.5±5.5 ml/100 g/min, respectively. The patients with VD demonstrated significantly reduced mCBF and rCBF in twenty regions including both cerebellar hemispheres as compared with those of the control group. Although there was no significant rCBF differences in bilateral inferior occipital regions and the right cerebellar hemisphere between patients with VD and multiple lacunar infarction without cognitive dysfunction, we could find significant lower rCBF in the remaining brain areas. In spite of the severity of VD, the diffuse decrease of cerebral blood flow was recognized in all patients with VD. (author)

Mining Research Laboratories annual report, 1984-85. Rapport annuel des Laboratoires de recherche miniere, 1984-1985

Energy Technology Data Exchange (ETDEWEB)

Sabourin, C.A.

1985-05-01

One of the main objectives of CANMET's Energy Research program is to develop the technologies required to conserve and to increase the supply of liquid fossil fuels in Canada to bridge the gap that exists between domestic supply and demand (both internal demand and export opportunities). The Energy Research Laboratories (ERL) respond to this R D objective on matters related to the upgrading of oil sands; heavy oil and synthetic crude production; coal/bitumen coprocessing; and improved oil and gas domestic heating furnaces. Another major objective is to develop the technologies to burn fossil fuels, mainly coal, under environmentally acceptable conditions; ERL responds to this objective through research in the areas of coal combustion and gasification. This report summarizes the activities of ERL during the fiscal year 1984/85. A recent reorganization of the ERL is summarily described. The total expenses of ERL in 1984/85 were 169 persons/year, $6.375 million in salaries, $3.499 million in operating costs, $2.740 million in capital investments, and $10,000 million in contracts. Included in the report are listings of employees, patents, publications, technical committees, and contracts. 2 figs., 2 tabs.

Cerebral perfusion changes in traumatic diffuse brain injury. IMP SPECT studies

International Nuclear Information System (INIS)

Ito, Hiroshi; Kawashima, Ryuta; Fukuda, Hiroshi; Ishii, Kiyoshi; Onuma, Takehide.

1997-01-01

Diffuse brain injury (DBI) is characterized by axonal degeneration and neuronal damage which cause diffuse brain atrophy. We have investigated the time course of abnormalities in cerebral perfusion distribution in cases of DBI by using Iodine-123-IMP SPECT, and the relationship to the appearance of diffuse brain atrophy. SPECT scans were performed on eight patients with diffuse brain injury due to closed cranial trauma in acute and chronic stages. All patients showed abnormalities in cerebral perfusion with decreases in perfusion, even in non-depicted regions on MRI, and the affected areas varied throughout the period of observation. Diffuse brain atrophy appeared in all patients. In some patients, diffuse brain atrophy was observed at or just after the time when the maximum number of lesions on SPECT were seen. The abnormalities in cerebral perfusion in cases of DBI might therefore be related to axonal degeneration and neuronal damage which causes diffuse brain atrophy. (author)

2006 Guidelines for Advancement and Promotion

CERN Multimedia

HR Department

2006-01-01

1. General The Director-General has now fixed the guidelines and schedule for the 2006 annual advancement review in the framework of the Merit Advancement and Promotion Scheme (MAPS). Procedures are set out in Administrative Circular 26 (Rev. 6). All decisions will be made by 1 July 2006. These now include career path changes for staff in Career Paths A to D. Departments are invited to comply strictly with the target date for the completion of the annual interviews which this year has been fixed at 15 March 2006. Group Leader evaluations are expected to be finalized by 13 April 2006. Exceptions due to particular circumstances (e.g. long-term absences) must be documented. The annual appraisal report should be completed using the electronic version in the EDH system. 2. Budget guidelines Within the annual advancement budget, the guideline allocations have been defined by the Director-General on a departmental basis for staff in Career Paths A to E and on a CERN-wide basis for staff in Career Paths F and ...

2006 Guidelines for Advancement and Promotion

CERN Multimedia

HR Department

2006-01-01

1. General The Director-General has now fixed the guidelines and schedule for the 2006 annual advancement review in the framework of the Merit Advancement and Promotion Scheme (MAPS). Procedures are set out in Administrative Circular 26 (Rev. 6). All decisions will be made by 1 July 2006. These now include career path changes for staff in Career Paths A to D. Departments are invited to comply strictly with the target date for the completion of the annual interviews which this year has been fixed at 15 March 2006. Group Leader evaluations are expected to be finalized by 13 April 2006. Exceptions due to particular circumstances (e.g. long-term absences) must be documented. The annual appraisal report should be completed using the electronic version in the EDH system. 2. Budget guidelines Within the annual advancement budget, the guideline allocations have been defined by the Director-General on a departmental basis for staff in Career Paths A to E and on a CERN-wide basis for staff in Career Paths F and G...

Pionierin der Religionspsychologie: Marianne Beth (1890-1984)

NARCIS (Netherlands)

Belzen, J.A.

2010-01-01

This article deals with the contributions to the psychology of religion made by Dr. Marianne Beth (1890-1984), an almost totally forgotten pioneer of the psychology of religion. The article especially contextualizes her initiative to turn "unbelief" into a topic for research in psychology of

Temperature profiles from XBT casts from NOAA Ship ALBATROSS IV as part of the Marine Resources Monitoring, Assessment and Prediction (MARMAP) project from 1984-04-17 to 1984-06-02 (NODC Accession 8400111)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profiles were collected from XBT casts from NOAA Ship ALBATROSS IV from 17 April 1984 to 02 June 1984. Data were collected by the National Marine...

Assessment of cerebral benzodiazepine receptor distribution in anxiety disorders by 123I-iomazenil-SPECT. Comparison to cerebral perfusion scintigraphy by 123I-IMP

International Nuclear Information System (INIS)

Uchiyama, Mayuki; Sue, Hironari; Fukumitsu, Nobuyoshi; Mori, Yutaka; Kawakami, Kenji

1997-01-01

123 I-Iomazenil ( 123 I-IMZ) and 123 I-IMP imaging were performed in 5 patients with anxiety disorder (PAD) and 6 normal volunteers (NV). On 123 I-IMZ delayed imaging, the 2 PAD showed abnormally decreased findings. In anxiety disorder, decreased accumulation on 123 I-IMZ delayed images was seen in left hippocampus and parahippocampal gyrus in one patient, in right frontal and temporal lobe and left occipital pole in the other. Compared with NV, PAD had lower 123 I-IMZ uptake on delayed image in right upper and left lower frontal cortices, indicating the involvement of the benzodiazepine receptor complex in anxiety disorder. Compared with grading for anxiety disorder with Hamilton anxiety scale (HAS) and delayed to early count ratios of 123 I-IMZ, negative correlation (R 123 I-IMP image, positive correlation (R>0.7) was recognized in the hippocampus, the parahippocampal gyrus, the lower outer temporal cortex and the lower frontal cortex. (author)

'AER Working Group D On WWER Safety Analysis' Report Of The Meeting In Pisa, Italy, 26-27 April 2006

International Nuclear Information System (INIS)

Siltanen, P.

2006-01-01

AER Working Group D on WWER reactor safety analysis held its 15 t h meeting in Grand Hotel Duomo in Pisa, Italy during the period 26-27 April 2006. The meeting was hosted by the University of Pisa following the fourth workshop on the OECD/DOE/CEA WWER-1000 Coolant Transient Benchmark (W1000-CT) held at the same location on 24-25 April. Altogether 15 participants attended the Working Group D meeting, 11 from AER member organizations and 4 guests from non-member organizations. The coordinator for the working group, Mr. P. Siltanen (FNS) served as chairman. In addition to general information exchange on recent activities in the participating organizations, the topics of the meeting included: 1) Code development and benchmarking for reactor dynamics applications. 2) Safety analysis methodology and results. 3) Future activities. A list of participants and a list of handouts distributed at the meeting are attached to the report (Author)

A comparative study of simple methods to quantify cerebral blood flow with acetazolamide challenge by using iodine-123-IMP SPECT with one-point arterial sampling

Energy Technology Data Exchange (ETDEWEB)

Ohkubo, Masaki [Niigata Univ. (Japan). School of Health Sciences; Odano, Ikuo

2000-04-01

The aim of this study was to compare the accuracy of simplified methods for quantifying rCBF with acetazolamide challenge by using {sup 123}I-N-isopropyl-p-iodoamphetamine (IMP) and SPECT with one-point arterial sampling. After acetazolamide administration we quantified rCBF in 12 subjects by the following three methods: (a) the modified microsphere method, (b) the IMP-autoradiographic (ARG) method based on a two-compartment one-parameter model, and (c) the simplified method based on a two-compartment two-parameter model (functional IMP method). The accuracy of these methods was validated by comparing rCBF values with those obtained by the standard method: the super-early microsphere method with continuous withdrawal of arterial blood. On analyzing rCBF in each flow range (0-0.25, 0.25-0.5, 0.5-0.75 and more than 0.75 ml/g/min), rCBF values obtained by both methods (a) and (c) showed significant correlations (p<0.01) with those obtained by the standard method in every range, but rCBF values obtained by method (b) did not significantly correlated in the high flow range (0.5-0.75 and more than 0.75 ml/g/min). Method (c) was found to be the most accurate, even though it needs two serial SPECT scans. When requiring one SPECT scan, method (a) was considered to be superior to method (b) because of its accuracy, especially in high flow regions loaded with acetazolamide. (author)

Data on the development of the West German power electric industry in 1984. Daten zur Entwicklung der Energiewirtschaft in der Bundesrepublik Deutschland im Jahre 1984

Energy Technology Data Exchange (ETDEWEB)

1985-07-01

An introductory survey of international and national energy policies in 1984 as well as of the energy supply situation in the Federal Republic of Germany is followed by statistics, tables and diagrams containing significant data of energy economics. In particular, they refer to the primary energy balance, structure of energy consumption, import and export of energy supplies and the development on the hard coal, brown coal, mineral oil, electricity and gas market (reserves, application, prices). The year under review, 1984, is related to and compared with previous years reaching back as far as 1970.

(Networking + Integrating) * (Systems + Society). Proceedings of the Annual Canadian Conference of Information Science (12th, Toronto, Ontario, May 14-16, 1984) = (Reseaux + Integration) * (Systemes + Societe). Comptes rendus de la conference annuelle Canadienne des sciences de l'information (12th, Toronto, Ontario, 14-16 mai, 1984).

Science.gov (United States)

Canadian Association for Information Science, Ottawa (Ontario).

Seventeen papers from the 1984 annual conference of the Canadian Association for Information Science (CAIS) are presented in four broad topic areas. The first group, which focuses on changing roles in information access, includes the keynote address by Charles Meadow, "Integrating Access to Information Utilities: Promises, Problems, and…

Effect of cerebral blood flow on consciousness and outcome after head injury. Assessment by jugular bulb venous metabolism and IMP-SPECT

Energy Technology Data Exchange (ETDEWEB)

Imaizumi, Shigeki; Onuma, Takehide; Motohashi, Osamu; Kameyama, Motonobu; Ishii, Kiyoshi [Sendai City Hospital (Japan)

2002-10-01

This study was performed to elucidate the therapeutical value of arteriojugularvenous oxygen difference (AVDO{sub 2}) in the ultra-emergent period after head injury. Rational therapeutic strategy after severe head injury needs information concerning the dynamical change of cerebral blood flow (CBF) and metabolism. We monitored the cerebral venous metabolism within 6 hours after head injury until the day IMP-SPECT was performed. Whole brain cerebral blood flow detected by IMP-SPECT and AVDO{sub 2} at the same day was compared, which restored to the period within 6 hours after head injury. From this procedure, we could outline cerebral blood flow conditions by only AVDO{sub 2} without IMP-SPECT in the ultra-emergent period. Eighty-six patients with head injury who were carried to our emergency center in the period of recent 2 years aged ranging from 15 to 94 years were the subjects. They all performed jugular bulb cannulation within 6 hours after the accident (Martin's phase I: day 0) to know saturation of jugular vein (SjO{sub 2}), AVDO{sub 2} and AVL. They were monitored until the day IMP-SPECT was performed (Martin's phase II; day 1-3 or phase III; day 4-15). The correlation between CBF and AVDO{sub 2}. The effect of CBF and cerebral venous metabolism on consciousness and outcome was also analyzed. CBF and AVDO{sub 2} in phase II and III were reversely correlated (p<0.0001). Normal CBF corresponded with 5.0 vol% in AVDO{sub 2}. AVDO{sub 2} in all cases changed 6.2 vol% at phase I, 4.5 vol% at phase II and 5.1 vol% at phase III. Glasgow comascale (GCS) on admission under 8 (n=47) and over 9 (n=39) significantly differed in AVDO{sub 2} and CBF in the period of II and III. The patients with favorable consciousness showed low AVDO{sub 2} and hyperemia afterwards. Dead cases in phase I (n=19) showed high AVDO{sub 2} and low SjO{sub 2}. The patients with severe disability (SD) (n=13) showed high AVDO{sub 2} and low CBF and the patients with good recovery (GR

Swiss electricity statistics 2006; Schweizerische Elektrizitaetsstatistik 2006/Statistique suisse de l'electricite 2006

Energy Technology Data Exchange (ETDEWEB)

NONE

2007-07-01

This comprehensive report made by the Swiss Federal Office of Energy (SFOE) presents the statistics on electricity production and usage in Switzerland for the year 2006. First of all, an overview of Switzerland's electricity supply in 2006 is presented. Details are noted of the amounts generated by different sources including nuclear, hydro-power, storage schemes and thermal power stations as well as energy transfer with neighbouring countries. A second chapter takes a look at the balance of imports and exports with illustrative flow diagrams along with tables for total figures from 1950 through to 2006. For the summer and winter periods, figures from 1995 to 2006 are presented. The third chapter examines the production of electricity in the various types of power stations and the developments over the years 1950 to 2006, whereby, for example, statistics on regional generation and power station type are looked at. The fourth chapter looks at electricity consumption in various sectors from 1983 to 2006 and compares the figures with international data. The fifth chapter looks at generation, consumption and loading on particular, selected days and chapter six considers energy exchange with Switzerland's neighbours. Chapter seven takes a look at possibilities for extending generation facilities in the period up to 2013.

Organic research section. 1984 review and 1985 programs

International Nuclear Information System (INIS)

Glass, R.W.

1985-02-01

This report reviews the major activities and accomplishments of the Organic Research Section in 1984 and presents the 1985 work program. The three major areas of the Section's research work are non-metallic materials which includes applications and uses of plastics, petroleum products, coatings and elastomers; reactor waste management; and activity transport/decontamination of nuclear systems. In 1984, 50% of the Section's resources were used on studies in support of nuclear generation, 13% on reactor waste, and 37% on general activities and work in support of utilization, transmission and distribution, and thermal and hydraulic programs. About 60% of the section's work was supported by transfer and revenue funds as a result of urgent short-term work requirements which resulted in 68% of the work falling into the technical investigation, consulting and testing categories

Environmental monitoring at Hanford for 1984. Supplement

International Nuclear Information System (INIS)

Price, K.R.; Carlile, J.M.V.; Dirkes, R.L.; Jaquish, R.E.; Trevathan, M.S.; Woodruff, R.K.

1986-01-01

A range fire started on private land on August 10, 1984, and burned northward onto the Department of Energy's Hanford Site. Environmental monitoring results from air samples collected during and after the fire indicated that no radioactive materials different from normal levels were present in the air

Main Belt Comet P/2006 VW139: A Fragment from a Recent Collision?

Science.gov (United States)

Novakovic, B.; Hsieh, H. H.; Cellino, A.

2012-05-01

We applied different methods to examine a possibility that main belt comet P/2006VW139, recently discovered by the Pan-STARRS 1, belongs to a small group of 24 asteroids. Results show strong evidence that P/2006VW139 really belongs to this group.

Eighteenth LAMPF users group meeting: proceedings

International Nuclear Information System (INIS)

Bradbury, J.N.

1985-03-01

The Eighteenth Annual LAMPF Users Group Meeting was held October 29-30, 1984, at the Clinton P. Anderson Meson Physics Facility. The program included a number of invited talks on various aspects of nuclear and particle physics as well as status reports on LAMPF and discussions of upgrade options. The LAMPF working groups met and discussed plans for the secondary beam lines, experimental programs, and computing facilities

Metals and Ceramics Division progress report for period ending June 30, 1984

Energy Technology Data Exchange (ETDEWEB)

Brogden, I. (ed.)

1984-09-01

This progress report covers the research and development activities of the Metals and Ceramics Division from January 1, 1983, through June 30, 1984. The format of the report follows the organizational structure of the division. Short summaries of technical work in progress in the various experimental groups are presented in six parts. Chapter 1 deals with the research and development activities of the Engineering Materials Section, Chapter 2 with the Processing Science and Technology Section, Chapter 3 with the Materials Science Section, Chapter 4 with Project Activities, Chapter 5 with Specialized Research Facilities and Equipment, and Chapter 6 with Miscellaneous Activities.

Metals and Ceramics Division progress report for period ending June 30, 1984

International Nuclear Information System (INIS)

Brogden, I.

1984-09-01

This progress report covers the research and development activities of the Metals and Ceramics Division from January 1, 1983, through June 30, 1984. The format of the report follows the organizational structure of the division. Short summaries of technical work in progress in the various experimental groups are presented in six parts. Chapter 1 deals with the research and development activities of the Engineering Materials Section, Chapter 2 with the Processing Science and Technology Section, Chapter 3 with the Materials Science Section, Chapter 4 with Project Activities, Chapter 5 with Specialized Research Facilities and Equipment, and Chapter 6 with Miscellaneous Activities

Effects of exogenous inosine monophosphate on growth performance, flavor compounds, enzyme activity, and gene expression of muscle tissues in chicken.

Science.gov (United States)

Yan, Junshu; Liu, Peifeng; Xu, Liangmei; Huan, Hailin; Zhou, Weiren; Xu, Xiaoming; Shi, Zhendan

2018-04-01

The goal of this experiment was to examine effects of diets supplemented with exogenous inosine monophosphate (IMP) on the growth performance, flavor compounds, enzyme activity and gene expression of chicken. A total of 1,500 healthy, 1-day-old male 3-yellow chickens were used for a 52-d experimental period. Individuals were randomly divided into 5 groups (group I, II, III, IV, V) with 6 replicates per group, and fed a basal diet supplemented with 0.0, 0.05, 0.1, 0.2, and 0.3% IMP, respectively. There was no significant response to the increasing dietary IMP level in average daily feed intake (ADFI), average daily gain (ADG), and feed:gain ratio (F/G) (P ≥ 0.05). IMP content of the breast and thigh muscle showed an exponential and linear response to the increasing dietary IMP level (P exogenous IMP was fed. There were significant effects of IMP level in diet on free amino acids (FAA) (exponential, linear and quadratic effect, P exogenous IMP was fed. Dietary IMP supplementation had a quadratic effect on 5΄-NT and the alkaline phosphatase (ALP) enzyme activity in the breast muscle (P exogenous IMP group had the highest (AMPD1) gene expression of the breast muscle and ATIC gene expression of the thigh muscle. These results indicate that dietary IMP did not affect the growth performance of chicken, the diet with 0.2 to 0.3% exogenous IMP is optimal to improve the meat flavor quality in chicken.

Survey of gaseous air pollutants at selected UK sites: XIX. Data digest for Stevenage, Hertfordshire, 1984

Energy Technology Data Exchange (ETDEWEB)

Broughton, G.F.J.; Bower, J.S.; Drury, V.; Lilley, K.; Powell, K.

1987-01-01

Ambient air-quality measurements of six gaseous pollutants continued during 1984 at Stevenage, Hertfordshire sponsored by the Department of the Environment. These data are presented here in the form of frequency distributions, averages, and other parameters for winter, summer, annual, and monthly periods. Time-series graphs of pollutant concentrations for 1984 and of the historical data base between April 1977 and December 1984 are also included.

Survey of gaseous air pollutants at selected UK sites: XVIII. Data digest for Sibton, Suffolk, 1984

Energy Technology Data Exchange (ETDEWEB)

Broughton, G.F.J.; Bower, J.; Drury, V.; Lilley, K.; Powell, K.

1987-01-01

Ambient air-quality measurements of ozone continued during 1984 at Sibton, Suffolk sponsored by the Department of the Environment. Insolation was also recorded. These data are presented in the form of frequency distributions, averages, and other parameters for winter, summer, annual, and monthly periods. Time-series graphs of ozone concentrations for 1984 and of the historical data base between July 1973 and December 1984 are also included.

Shutdowns/scrams at BWRs reported under new 1984 LER rule

International Nuclear Information System (INIS)

Mays, G.T.

1985-01-01

Operating experience data from nuclear power plants are essential for safety and reliability analyses. The Licensee Event Reports (LERs), submitted to the NRC by nuclear power plant utilities, contain much of this data. One of the significant aspects of the new LER rule includes the requirement to report all plant shutdowns whereas prior to 1984, not all shutdowns were reported as LERs. This paper reviews the shutdowns and scrams occurring during the first six months of 1984 at BWRs as reported under the new LER rule. The review focused on systems involved, causes, and personnel interactions

The structure of the inner heliosphere from Pioneer Venus and IMP observations

Science.gov (United States)

Gazis, P. R.; Barnes, A.; Mihalov, J. D.; Lazarus, A. J.

1992-01-01

The IMP 8 and Pioneer Venus Orbiter (PVO) spacecraft explore the region of heliographic latitudes between 8 deg N and 8 deg S. Solar wind observations from these spacecraft are used to construct synoptic maps of solar wind parameters in this region. These maps provide an explicit picture of the structure of high speed streams near 1 AU and how that structure varies with time. From 1982 until early 1985, solar wind parameters varied little with latitude. During the last solar minimum, the solar wind developed strong latitudinal structure; high speed streams were excluded from the vicinity of the solar equator. Synoptic maps of solar wind speed are compared with maps of the coronal source surface magnetic field. This comparison reveals the expected correlation between solar wind speed near 1 AU, the strength of the coronal magnetic field, and distance from the coronal neutral line.

Gaz de France 2006 sustainable development report; Gaz de France 2006 rapport developpement durable

Energy Technology Data Exchange (ETDEWEB)

NONE

2006-07-01

A major European energy utility, the Gaz de France Group produces, purchases, transports, distributes and sells natural gas, electricity and related services for its residential, corporate and local government customers. this report presents the actions implemented by the group to incorporate sustainable development into its strategy. From the point of view of risks and opportunities, the group analyzes what it takes to ensure development that respects people and the environment, and it implements them in all its business lines and management systems. Content: Gaz de France, portrait of a major energy utility, highlights of 2006, challenges and strategy (defining strategy and sustainable development policy, specific risks and opportunities, activities of the Gaz de France group: challenges, impact for stakeholders, transparency and independence in governing), ranking and implementing (defining sustainable development policy: reviewing priorities, meeting all the challenges, publicizing and defending positions, increasing awareness, overseeing and monitoring results), results of the 2004-2006 sustainable development action plan, dialogue and action with stakeholders, performance assessment, performance in response to challenges: energy challenges (guaranteeing regular supplies, controlling atmospheric emissions, promoting energy conservation, developing renewable energy), industrial challenges (ensuring health and safety, limiting the overall environmental impact of group activities), social responsibility challenges (advocating corporate social responsibility, promoting human rights and fighting corruption, encouraging commitment to solidarity, promoting regional development through local initiatives, reconciling acquisitions, procurement and sustainable development, ensuring transparency in natural gas rates, providing shareholders with quality information, promoting diversity, a source of enrichment, making working conditions a performance factor), indicators and

Periodic Review Report: April 1984-June 1988.

Science.gov (United States)

Williamsport Area Community Coll., PA.

This report documents actions, accomplishments, and modifications at the Williamsport Area Community College (WACC) between April 1984 and June 1988. First, an executive summary highlights the following: (1) in 1985, WACC underwent a significant change in its governance when the City of Williamsport became the college's sole sponsor; (2) as a…

The Type II supernovae 2006V and 2006au

DEFF Research Database (Denmark)

Taddia, F.; Stritzinger, M. D.; Sollerman, J.

2012-01-01

curve evolution similar to that of SN 1987A. At the earliest epochs, SN 2006au also displays an initial dip which we interpret as the signature of the adiabatic cooling phase that ensues shock break-out. SNe 2006V and 2006au are both found to be bluer, hotter and brighter than SN 1987A. Spectra of SNe...

Single photon emission computed tomography (SPECT) findings using N-isopropyl-p-[123I]iodoamphetamine (123I-IMP) in schizophrenia and atypical psychosis

International Nuclear Information System (INIS)

Suga, Hidemichi

1993-01-01

Sixteen schizophrenic patients, 16 atypical psychosis patients, and 16 healthy volunteers were subjected to single photon emission computed tomography (SPECT) of the brain using N-isopropyl-p-[ 123 I]iodoamphetamine ( 123 I-IMP). The basal ganglia region was in particular examined not only in transverse sections, but in coronal sections. Schizophrenics showed significantly decreased uptake rates in the bilateral frontal regions and increased uptakes in the bilateral basal ganglia. On the other hand, atypical psychotics had a reduced uptake rate only in the right thalamic region, compared to the controls. The increased uptake rates in the basal ganglia were associated with auditory hallucination, but gender difference, duration of illness and dose of neuroleptics had no influence on these SPECT findings. The results suggest that schizophrenics might have some lesions in the frontal area of the brain, whereas atypical psychotics might have no lesion in the frontal region but dysfunction in the right thalamic region. Subsequently, using only SPECT findings, all the cases were divided by cluster analysis into 4 groups and a residue group. Schizophrenics distributed mainly in the 2 groups that have lesion in the frontal regions. Atypical psychotics distributed principally in the other 2 groups that have alterations in the bilateral thalamic region. The present study suggests that schizophrenia and atypical psychosis might have different etiologies. (author)

Strontium-90 and cesium-137 in milk (consuming districts) (from Jul. 1984 to Sep. 1984)

International Nuclear Information System (INIS)

1984-01-01

Sr-90 and Cs-137 in milk from consuming districts were determined using radiochemical analysis. Commercial milk was purchased from 23 sampling locations. Milk in a stainless steel pan or a porcelain dish was evaporated to dryness followed by carbonization and ashing. The maximum values of Sr-90 and Cs-137 were 2.7 +- 0.28 pCi/l in milk from Akita and 5.3 +- 0.31 pCi/l in milk from Fukushima purchased in August 1984, respectively. (Namekawa, K.)

Modulation of growth performance, immunological responses and disease resistance of juvenile Nile tilapia (Oreochromis niloticus (Linnaeus, 1758 by supplementing dietary inosine monophosphate

Directory of Open Access Journals (Sweden)

Md. Abdul Kader

2018-05-01

Full Text Available This study was investigated to examine supplemental effects of dietary inosine monophosphate (IMP on growth performance, feed utilization, biochemical, hematological and immunological parameters of juvenile Nile tilapia Oreochromis niloticus. Disease resistance to experimental infection with Streptococcus agalactiae was also assessed. A semi-purified basal diet was supplemented with 0 (IMP0, Control, 1 (IMP1, 2 (IMP2, 4 (IMP4 and 8 (IMP8 g purified IMP kg−1 diet to formulate five experimental diets. Each diet was randomly allocated to triplicate groups of fish (0.59 g for 60 days. The results indicated that supplementation of IMP significantly (P  0.05. Among whole body proximate composition and somatic parameters, condition factor was significantly influenced by dietary supplementation of IMP. A wide variation in hematological parameters were observed and dietary supplementation increased the hematocrit content (P  0.05. Total serum protein (TSP, lysozyme activity (LA, superoxide dismutase activity (SOD and bactericidal activity (BA tended to increase with the supplementation of dietary IMP. TSP and SOD were significantly improved with ≥4 g kg−1 supplementation, while LA with 8 g kg−1 and BA with ≥1 g kg−1 supplementations. IMP supplemented groups showed higher (P > 0.05 cumulative survival compared to that of supplementation free control group. IMP supplemented diet groups also showed significantly higher BA in the post challenge test. Based on the overall performances, the results of the current study indicated that the inclusion of IMP in Nile tilapia diet can improve growth performance, feed utilization, haematological and immunological parameters; and disease resistance of juvenile Nile tilapia. Keywords: Nucleotides, Inosine monophosphate, Growth, Immunity, Disease resistance, Nile tilapia, Streptococcus agalactiae

N-isopropyl-p-[I[sup 123

Energy Technology Data Exchange (ETDEWEB)

Tada, Hiroshi; Morooka, Keiichi; Arimoto, Kiyoshi; Matsuo, Takiko; Takagi, Kazue; Yanagawa, Etsuko (Toho Univ., Tokyo (Japan). School of Medicine)

1992-09-01

We studied the clinical usefulness of I[sup 123]-IMP SPECT in 50 pediatric patients with CNS disorders, which were categorized into the convulsive disorder group (n=20), the cerebrovascular disorder group (n=10), the acute encephalopathy or CNS infection group (n=10), the metabolic or degenerative disorder group (n=6), the congenital abnormality group (n=2) and the migraine group (n=2). The findings obtained were compared with those of cranial CT. I[sup 123]-IMP SPECT revealed abnormal findings in 45 out of the 50 patients (90%), although cranial CT showed abnormal findings in only 24 patients (48%). This difference was statistically significant (p<0.01). In all groups except the migraine, we could find abnormal findings in more than 90% of the patients. Out of 28 patients without focal findings on the initial CT scanning. I[sup 123]-IMP SPECT showed focal abnormalities in 26 patients (93%). Moreover in many patients with focal neurological abnormalities, we found focal abnormalities of I[sup 123]-IMP SPECT related with neurological abnormalities of the patients. From these findings, we think I[sup 123]-IMP SPECT might be superior to CT scanning in examining a localized lesion. It was found that in many patients with focal abnormalities in CT scanning, I[sup 123]-IMP SPECT showed larger abnormalities in CT scanning. By using I[sup 123]-IMP SPECT we might be able to study the blood perfusional state surrounding the abnormal area shown by CT. In 3 patients with acute cerebrovascular disorders, I[sup 123]-IMP SPECT revealed abnormal findings 3 to 11 days earlier than cranial CT. I[sup 123]-IMP SPECT might be useful for early recognition of the pathological state. From these experiences, we concluded that I[sup 123]-IMP SPECT was useful for studying the pathophysiology of CNS disorders in children. (author).

CERN Technical Training 2006: LabVIEW Course Sessions (September-December 2006)

CERN Multimedia

2006-01-01

The following LabVIEW course sessions are currently scheduled in the framework of the CERN Technical Training Programme 2006, and in collaboration with National Instruments (CH): LabVIEW Basics 1 (course in English): 11-13.9.2006 (3 days, only 3 places available) LabVIEW Basics 2 (course in English): 14-15.9.2006 (2 days) LabVIEW: Working efficiently with LabVIEW 8 (course in English): 18.9.2006 (1 day) **NEW COURSE** LabVIEW Application Development (course in English): 13-15.11.2006 (3 days. Pre-requisite: LabVIEW Basics I ans II, or equivalent experience) LabVIEW Advanced Programming (course in English): 16-17.11.2006 (2 days. Pre-requisite: LabVIEW Application Development, or equivalent experience) LabVIEW Base 1 (course in French): 4-6.12.2006 (3 days, only 1 place available) LabVIEW Base 2 (course in French): 7-8.12.2006 (2 days) If you are interested in attending any of the above course sessions, please discuss with your supervisor and/or your DTO, and apply electronically via EDH from the cour...

Oxygenated organic functional groups and their sources in single and submicron organic particles in MILAGRO 2006 campaign

Directory of Open Access Journals (Sweden)

S. Liu

2009-09-01

Full Text Available Fourier Transform Infrared (FTIR and X-ray Fluorescence (XRF were used to measure organic functional groups and elements of submicron particles collected during MILAGRO in March 2006 on three platforms: the Mexico City urban area (SIMAT, the high altitude site at 4010 m (Altzomoni, and the NCAR C130 aircraft. Scanning Transmission X-ray Microscopy (STXM and Near-Edge X-ray Absorption Fine Structure (NEXAFS were applied to single particle organic functional group abundance analysis of particles simultaneously collected at SIMAT and C130. Correlations of elemental concentrations showed different groups of source-related elements at SIMAT, Altzomoni, and C130, suggesting different processes affecting the air masses sampled at the three platforms. Cluster analysis resulted in seven distinct clusters of FTIR spectra, with the last three clusters consisting of spectra collected almost exclusively on the C130 platform, reflecting the variety of sources contributing to C130 samples. Positive Matrix Factorization (PMF of STXM-NEXAFS spectra identified three main factors representing soot, secondary, and biomass burning type spectra. PMF of FTIR spectra resulted in two fossil fuel combustion factors and one biomass burning factor, the former representative of source regions to the northeast and southwest of SIMAT. Alkane, carboxylic acid, amine, and alcohol functional groups were mainly associated with combustion related sources, while non-acid carbonyl groups were likely from biomass burning events. The majority of OM and O/C was attributed to combustion sources, although no distinction between direct emissions and atmospherically processed OM could be identified.

Cerebral blood flow single-photon emission tomography with {sup 123}I-IMP in vascular dementia

Energy Technology Data Exchange (ETDEWEB)

Kawahata, Nobuya; Gotoh, Chiharu; Yokoyama, Sakura; Daitoh, Nobuyuki [Narita Memorial Hospital, Toyohashi, Aichi (Japan)

2001-06-01

Cerebral blood flow differences between patients with vascular dementia, patients with multiple lacunar infarction without cognitive dysfunction, and age-matched controls were examined. Thirty four patients with vascular dementia (VD) were selected from consecutive referrals to the Memory Clinic at Narita Memorial Hospital. All the patients had routine assessment including history, physical and neurological examinations, neuropsychological assessment, blood tests, EEG, head MRI, and single photon emission computed tomography (SPECT). All of them fulfilled the NINDS-AIREN diagnostic criteria for vascular dementia. Thirty nine patients with multiple lacunar infarction without cognitive dysfunction and 110 age-matched controls were included in this study. Mean cerebral blood flow (mCBF) and regional cerebral blood flow (rCBF) were measured using N-isopropyl-P-{sup 123}I-iodoamphetamine ({sup 123}I-IMP) and SPECT imager. The mCBF in VD was 27.6{+-}5.3 ml/100 g/min, while those in the control group and multiple lacunar infarction without cognitive dysfunction were 36.6{+-}6.1 ml/100 g/min and 32.5{+-}5.5 ml/100 g/min, respectively. The patients with VD demonstrated significantly reduced mCBF and rCBF in twenty regions including both cerebellar hemispheres as compared with those of the control group. Although there was no significant rCBF differences in bilateral inferior occipital regions and the right cerebellar hemisphere between patients with VD and multiple lacunar infarction without cognitive dysfunction, we could find significant lower rCBF in the remaining brain areas. In spite of the severity of VD, the diffuse decrease of cerebral blood flow was recognized in all patients with VD. (author)

State-of-art report III/1984 (June 29 to November 27, 1984)

International Nuclear Information System (INIS)

1985-01-01

The state-of-art report III/1984 gives a survey of the activities of the Nuclear Committee (KTA) and its panels and of KTA regulation projects in the period between the 35th and 36th KTA meeting. The state-of-art report is designed to give fast, synoptical, adequate information on the current state of KTA work. With regulation projects, data which are subject to miner variations only, for instance concerning the contents or organization of a regulation project, data on the flow of work, members of the panels, are included in the KTA manual. In case of alterations, the data in the KTA manual are updated by replacing the respective pages. (orig./HP) [de

Account 1983-1984. [National Radiological Protection Board

Energy Technology Data Exchange (ETDEWEB)

1984-01-01

Account prepared pursuant to section 3 (4) of the Radiological Protection Act 1970 of the receipts and payments of the National Radiological Protection Board for the year ended 31st March 1984; together with the Report of the Comptroller and Auditor General thereon. (In continuation of House of Commons Paper No. 149 of 1983-84).

El Caso del Dinero Desaparecido Chile 1984-1986

OpenAIRE

Felipe Larraín; Aníbal Larraín

1988-01-01

Between the third quarter of 1984 and the second one of 1986, Chile's real money balances (seasonally adjusted, real MI) decreased by 11%. In the same period, Gross Domestic Product grew by 12.3% and the effective short-term interest rate systematically d

1984 Statistical symposium on national energy issues: proceedings

International Nuclear Information System (INIS)

Kinnison, R.; Doctor, P.

1985-07-01

The 1984 Statistical Symposium on National Energy Issues was the tenth in a series of annual symposia bringing together statisticians and other interested parties who are actively engaged in the pursuit of solving the nation's energy problems. Initially the symposium was sponsored by US Department of Energy (DOE) and named the DOE Statistical Symposium. The symposium is organized by a steering committee made up of representatives from the national laboratories. The 1984 symposium was hosted by Pacific Northwest Laboratory, and it was organized around four special topical sessions: (1) assessing and assuring high reliability, (2) spatial statistical, (3) quantification of informed opinion, and (4) health effects of energy technologies. These were chosen by the steering committee as topics currently of high importance in energy research and data analysis. Several contributed papers were also presented. Separate abstracts have been prepared for 17 papers for inclusion in the Energy Data Base

Survey of gaseous air pollutants at selected UK sites: XX. Data digest for Central London Laboratory, 1984

Energy Technology Data Exchange (ETDEWEB)

Broughton, G.F.J.; Bower, J.; Drury, V.J.; Lilley, K.; Powell, K.

1987-01-01

Ambient air-quality measurements of six gaseous pollutants plus black smoke and particulate lead continued during 1984 at the Central London Laboratory. The data are presented here in the form of frequency distributions, averages, and other parameters for winter, summer, annual and monthly periods. Time-series graphs of pollutant concentrations for 1984 and of the historical data base between July 1972 and December 1984 are also included.

Statutory instruments: 1984 No. 1261 Medicines - The Medicines (Committee on Radiation from Radioactive Medicinal Products) (Revocation) Order 1984

International Nuclear Information System (INIS)

1984-01-01

This Order, which came into force on 6 September 1984, revokes the Medicines (Committee on Radiation from Radioactive Medicinal Products) Order 1978 thereby abolishing the Committee, which was established for the purpose of giving advice on safety, quality and efficacy in relation to radiation involving any substance or article for human use to which the Medicins Act 1968 is applicable. (NEA) [fr

Promoção e divulgação no Brasil Império: Turismo na Monarquia

Directory of Open Access Journals (Sweden)

João dos Santos Filho

2010-02-01

Full Text Available

O presente trabalho é resultado da linha de pesquisa “Hospitalidade na história: um passeio pela cultura do Novo Mundo”, desenvolvido junto à Universidade Estadual de Maringá, a investigação histórica fundamenta-se em obras escritas sobre o Brasil e o povo Maya no século XVI, XVII, XVIII e XIX, compreendendo aproximadamente os anos de 1524 até 1890. As obras que constituem o objeto de nossa investigação foram escritas e publicadas ao período do Brasil-Império, essa literatura foi produzida por visitantes estrangeiros, que de forma diversa, souberam registrar e tratar o cotidiano da vida nacional. Esses autores vieram para o Brasil; morar, trabalhar, pesquisar ou passear, e resolveram documentar sua estada entre nós, com descrições muitas vezes específicas, mas que na verdade, tornaram-se verdadeiros compêndios historiográficos e alguns com farto material iconográfico sobre a história nacional.

Palavras-chaves: Turismo no Império, guia turístico imperial, historiografia do turismo nacional, eurocentrismo, etnocentrismo.

Rotational Seismology Workshop of February 2006

Science.gov (United States)

Evans, John R.; Cochard, A.; Graizer, Vladimir; Huang, Bor-Shouh; Hudnut, Kenneth W.; Hutt, Charles R.; Igel, H.; Lee, William H.K.; Liu, Chun-Chi; Majewski, Eugeniusz; Nigbor, Robert; Safak, Erdal; Savage, William U.; Schreiber, U.; Teisseyre, Roman; Trifunac, Mihailo; Wassermann, J.; Wu, Chien-Fu

2007-01-01

Introduction A successful workshop titled 'Measuring the Rotation Effects of Strong Ground Motion' was held simultaneously in Menlo Park and Pasadena via video conference on 16 February 2006. The purpose of the Workshop and this Report are to summarize existing data and theory and to explore future challenges for rotational seismology, including free-field strong motion, structural strong motion, and teleseismic motions. We also forged a consensus on the plan of work to be pursued by this international group in the near term. At this first workshop were 16 participants in Menlo Park, 13 in Pasadena, and a few on the telephone. It was organized by William H. K. Lee and John R. Evans and chaired by William U. Savage in Menlo Park and by Kenneth W. Hudnut in Pasadena. Its agenda is given in the Appendix. This workshop and efforts in Europe led to the creation of the International Working Group on Rotational Seismology (IWGoRS), an international volunteer group providing forums for exchange of ideas and data as well as hosting a series of Workshops and Special Sessions. IWGoRS created a Web site, backed by an FTP site, for distribution of materials related to rotational seismology. At present, the FTP site contains the 2006 Workshop agenda (also given in the Appendix below) and its PowerPoint presentations, as well as many papers (reasonable-only basis with permission of their authors), a comprehensive citations list, and related information. Eventually, the Web site will become the sole authoritative source for IWGoRS and shared information: http://www.rotational-seismology.org ftp://ehzftp.wr.usgs.gov/jrevans/IWGoRS_FTPsite/ With contributions from various authors during and after the 2006 Workshop, this Report proceeds from the theoretical bases for making rotational measurements (Graizer, Safak, Trifunac) through the available observations (Huang, Lee, Liu, Nigbor), proposed suites of measurements (Hudnut), a discussion of broadband teleseismic rotational

Metallurgy Department progress report for the period 1 January to 31 December 1984

International Nuclear Information System (INIS)

1985-04-01

The activities of the Metallurgy Department at Risoe during 1984 are described. The work is presented in three chapters: General Materials Research, Technology and Materials Development, and Fuel Elements. A survey is given of the Department's participation in international collaboration and of its activities within education and training. A list (with abstracts) of publications and lectures by the staff during 1984 is included. (author)

Progress report 1983-1984 Reactor Chemistry Department

International Nuclear Information System (INIS)

1985-11-01

Description of the activity developed by the Reactor Chemistry Department of the National Atomic Energy Commission during the period 1983-1984 in its four divisions: Chemical Control; Moderator and Refrigerant Chemistry; Radiation Chemistry and Nuclear Power Plant's Service. A list of the publications made by the personnel during this period is also included. (M.E.L.) [es

Detection of P. aeruginosa harboring bla CTX-M-2, bla GES-1 and bla GES-5, bla IMP-1 and bla SPM-1 causing infections in Brazilian tertiary-care hospital

Science.gov (United States)

2012-01-01

Background Nosocomial infections caused by Pseudomonas aeruginosa presenting resistance to beta-lactam drugs are one of the most challenging targets for antimicrobial therapy, leading to substantial increase in mortality rates in hospitals worldwide. In this context, P. aeruginosa harboring acquired mechanisms of resistance, such as production of metallo-beta-lactamase (MBLs) and extended-spectrum beta-lactamases (ESBLs) have the highest clinical impact. Hence, this study was designed to investigate the presence of genes codifying for MBLs and ESBLs among carbapenem resistant P. aeruginosa isolated in a Brazilian 720-bed teaching tertiary care hospital. Methods Fifty-six carbapenem-resistant P. aeruginosa strains were evaluated for the presence of MBL and ESBL genes. Strains presenting MBL and/or ESBL genes were submitted to pulsed-field gel electrophoresis for genetic similarity evaluation. Results Despite the carbapenem resistance, genes for MBLs (blaSPM-1 or blaIMP-1) were detected in only 26.7% of isolates. Genes encoding ESBLs were detected in 23.2% of isolates. The blaCTX-M-2 was the most prevalent ESBL gene (19.6%), followed by blaGES-1 and blaGES-5 detected in one isolate each. In all isolates presenting MBL phenotype by double-disc synergy test (DDST), the blaSPM-1 or blaIMP-1 genes were detected. In addition, blaIMP-1 was also detected in three isolates which did not display any MBL phenotype. These isolates also presented the blaCTX-M-2 gene. The co-existence of blaCTX-M-2 with blaIMP-1 is presently reported for the first time, as like as co-existence of blaGES-1 with blaIMP-1. Conclusions In this study MBLs production was not the major mechanism of resistance to carbapenems, suggesting the occurrence of multidrug efflux pumps, reduction in porin channels and production of other beta-lactamases. The detection of blaCTX-M-2,blaGES-1 and blaGES-5 reflects the recent emergence of ESBLs among antimicrobial resistant P. aeruginosa and the extraordinary

Detection of P. aeruginosa harboring bla CTX-M-2, bla GES-1 and bla GES-5, bla IMP-1 and bla SPM-1 causing infections in Brazilian tertiary-care hospital

Directory of Open Access Journals (Sweden)

Polotto Milena

2012-08-01

Full Text Available Abstract Background Nosocomial infections caused by Pseudomonas aeruginosa presenting resistance to beta-lactam drugs are one of the most challenging targets for antimicrobial therapy, leading to substantial increase in mortality rates in hospitals worldwide. In this context, P. aeruginosa harboring acquired mechanisms of resistance, such as production of metallo-beta-lactamase (MBLs and extended-spectrum beta-lactamases (ESBLs have the highest clinical impact. Hence, this study was designed to investigate the presence of genes codifying for MBLs and ESBLs among carbapenem resistant P. aeruginosa isolated in a Brazilian 720-bed teaching tertiary care hospital. Methods Fifty-six carbapenem-resistant P. aeruginosa strains were evaluated for the presence of MBL and ESBL genes. Strains presenting MBL and/or ESBL genes were submitted to pulsed-field gel electrophoresis for genetic similarity evaluation. Results Despite the carbapenem resistance, genes for MBLs (blaSPM-1 or blaIMP-1 were detected in only 26.7% of isolates. Genes encoding ESBLs were detected in 23.2% of isolates. The blaCTX-M-2 was the most prevalent ESBL gene (19.6%, followed by blaGES-1 and blaGES-5 detected in one isolate each. In all isolates presenting MBL phenotype by double-disc synergy test (DDST, the blaSPM-1 or blaIMP-1 genes were detected. In addition, blaIMP-1 was also detected in three isolates which did not display any MBL phenotype. These isolates also presented the blaCTX-M-2 gene. The co-existence of blaCTX-M-2 with blaIMP-1 is presently reported for the first time, as like as co-existence of blaGES-1 with blaIMP-1. Conclusions In this study MBLs production was not the major mechanism of resistance to carbapenems, suggesting the occurrence of multidrug efflux pumps, reduction in porin channels and production of other beta-lactamases. The detection of blaCTX-M-2,blaGES-1 and blaGES-5 reflects the recent emergence of ESBLs among antimicrobial resistant P. aeruginosa and

Strontium-90 and cesium-137 in sea sediments (from May 1984 to Sep 1984)

International Nuclear Information System (INIS)

1984-01-01

Strontium-90 and cesium-137 monitoring results are presented for sea sediment samples of 12 sampling points located all over Japan from Tomari, Hokkaido to Kinnakagusuku Bay, Okinawa. The samples were collected by considering of enough sea water depth, no significant sedimental movement and sediment characteristics, and by employing a conventional sampling device. Approximately 4 kg-wet sample was dried and was passed through a 20 cm mesh sieve. After adding of strontium and cesium carriers, strontium-90 and cesium-137 were leached with a hot hydrochloric acid solution. The leachate was treated by ion exchange and coprecipitation to concentrate and isolate strontium-90 or cesium-137. Radiation counting was carried out by employing a low background beta counter usually for 60 minutes for the samples of strontium carbonate or cesium chloroplatinate. Determined strontium-90 contents in sea sediment were distributed from 0 +- 2.7 pCi/kg-dry (Mutsu Bay, Aomori, Yamaguchi Bay, Yamaguchi) to 14 +- 3.2 pCi/kg-dry (Mutsu Bay), and those of cesium-137 were from 9 +- 3.5 pCi/kg-dry (Mutsu Bay) to 250 +- 9 pCi/kg-dry (Off-Niigata Port, Niigata). Local variation of the contents of these radionuclides was very large, and for seasonal variation, it was also found large for the both nuclides content in the Mutsu Bay samples of May, 1984 and August 1984, as for strontium-90, 0 +- 2.7 pCi/kg and 14 +- 3.2 pCi/kg, for cesium-137, 9 +- 3.5 pCi/kg and 200 +- 8 pCi/kg, respectively. (Takagi, S.)

Europython 2006

CERN Multimedia

2006-01-01

Europython 2006 - Annual Python Developer Conference, 3-5 July 2006, CERN Software developers from around the world will gather July 3-5 in Geneva, Switzerland for EuroPython 2006, the fifth annual conference for the Python programming language. The event is hosted this year at CERN, the birthplace of the Web, and promises an exciting slate of keynotes and talks. 'Python keeps growing each year, and EuroPython keeps getting better as well,' says Benedikt Hegner, host and one of the lead organizers for EuroPython 2006. 'This year saw Guido van Rossum, Python's creator, moving to Google with other key Python developers. Hosting EuroPython at CERN is a prestigious step for EuroPython as well. EuroPython 2006 will be keynoted both by Mr. van Rossum as well as Dr. Alan Kay, an originator of object-oriented programming and pioneer of graphical computing. The schedule has 3 days of talks in 8 tracks covering agile development, business, teaching, games, an expanded web frameworks track, and more. The organize...

HIV-1 group O infection in Cameroon from 2006 to 2013: Prevalence, genetic diversity, evolution and public health challenges

Science.gov (United States)

Villabona-Arenas, Christian Julian; Domyeum, Jenny; Mouacha, Fatima; Butel, Christelle; Delaporte, Eric; Peeters, Martine; Mpoudi-Ngole, Eitel; Aghokeng, Avelin Fobang

2015-01-01

The human immunodeficiency virus, HIV, is characterized by a tremendously high genetic diversity, leading to the currently known circulating HIV types, groups, subtypes, and recombinant forms. HIV-1 group O is one of the most diverse forms of HIV-1 and has been so far related to Cameroon or individuals originating from Cameroon. In this study, we investigated in Cameroon, the evolution of this viral group from 2006 to 2013, in terms of prevalence, genetic diversity and public health implications. Our results confirmed the predominance of HIV-1 group M (98.5%), a very low prevalence (O was found at around 0.6% (95% confidence interval: 0.4–0.8%), indicating that the frequency of this virus in Cameroon has remained stable over the last decades. However, we found an extensive high genetic diversity within this HIV-1 group, that resulted from previous steady increase on the effective number of HIV-1 group O infections through time, and the current distribution of the circulating viral strains still does not allow classification as subtypes. The frequency of dual infections with HIV-1 group M and group O was 0.8% (95% confidence interval: 0.6–1.0%), but we found no recombinant forms in co-infected patients. Natural resistance to integrase inhibitors was not identified, although we found several mutations considered as natural polymorphisms. Our study shows that infections with HIV-1 group O can be adequately managed in countries where the virus circulates, but this complex virus still represents a challenge for diagnostics and monitoring strategies. PMID:26371064

Carta a Joan Olmos (1984)

OpenAIRE

Jaén i Urban, Gaspar

1984-01-01

En este ítem se presentan dos documentos originales del autor: 1 - Las notas manuscritas para una conferencia impartida en la Facultad de Filosofía de Valencia sobre poesía y poéticas el 27 de enero de 1984. 2 – El mecanoscrito de una carta dirigida a Joan Olmos (en aquellos momentos director general de carreteras de la Generalitat Valenciana) lamentando la tala de unos árboles centenarios. Esta carta fue publicada en tres diarios de Valencia y Alicante y difundida por televisión: «Carta ober...

Piperacillin-tazobactam vs. imipenem-cilastatin as empirical therapy in hematopoietic stem cell transplantation recipients with febrile neutropenia.

Science.gov (United States)

Jing, Yu; Li, Jian; Yuan, Lei; Zhao, Xiaoli; Wang, Quanshun; Yu, Li; Zhou, Daobin; Huang, Wenrong

2016-03-01

This randomized, dual-center study compared the efficacy and safety of piperacillin-tazobactam (PTZ) and imipenem-cilastatin (IMP) in hematopoietic stem cell transplantation (HSCT) recipients with febrile neutropenia. HSCT recipients with febrile neutropenia were randomized into two groups receiving either PTZ or IMP as initial empiric antibiotic. Endpoints were defervescence rate after empiric antibiotic for 48 h, success at end of therapy, and side effects. Defervescence within 48 h after empiric antibiotic was observed in 46 patients with PTZ (75.4%) and 59 patients with IMP (95.2%) (p = 0.002). Ten patients (10/46) in the PTZ group and two patients (2/59) in the IMP group switched empiric antibiotics due to recurrent fever (p = 0.005). Success of initial antibiotic with modification was achieved in 34 patients with PTZ (55.7%) and 53 patients with IMP (85.5%) at the end of therapy (p = 0.001). To treat the bacteremia, seven of 10 patients in the PTZ group and one of eight patients in the IMP group needed to switch the empiric antibiotic (p = 0.025). Compared with PTZ, IMP had more gastrointestinal adverse events (p = 0.045). This study demonstrates that IMP had better efficacy than PTZ as an empiric antibiotic for febrile neutropenia in the HSCT setting, but with more gastrointestinal side reactions. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Measurement of regional cerebral blood flow using one-point arterial blood sampling and microsphere model with 123I-IMP. Correction of one-point arterial sampling count by whole brain count ratio

International Nuclear Information System (INIS)

Makino, Kenichi; Masuda, Yasuhiko; Gotoh, Satoshi

1998-01-01

The experimental subjects were 189 patients with cerebrovascular disorders. 123 I-IMP, 222 MBq, was administered by intravenous infusion. Continuous arterial blood sampling was carried out for 5 minutes, and arterial blood was also sampled once at 5 minutes after 123 I-IMP administration. Then the whole blood count of the one-point arterial sampling was compared with the octanol-extracted count of the continuous arterial sampling. A positive correlation was found between the two values. The ratio of the continuous sampling octanol-extracted count (OC) to the one-point sampling whole blood count (TC5) was compared with the whole brain count ratio (5:29 ratio, Cn) using 1-minute planar SPECT images, centering on 5 and 29 minutes after 123 I-IMP administration. Correlation was found between the two values. The following relationship was shown from the correlation equation. OC/TC5=0.390969 x Cn-0.08924. Based on this correlation equation, we calculated the theoretical continuous arterial sampling octanol-extracted count (COC). COC=TC5 x (0.390969 x Cn-0.08924). There was good correlation between the value calculated with this equation and the actually measured value. The coefficient improved to r=0.94 from the r=0.87 obtained before using the 5:29 ratio for correction. For 23 of these 189 cases, another one-point arterial sampling was carried out at 6, 7, 8, 9 and 10 minutes after the administration of 123 I-IMP. The correlation coefficient was also improved for these other point samplings when this correction method using the 5:29 ratio was applied. It was concluded that it is possible to obtain highly accurate input functions, i.e., calculated continuous arterial sampling octanol-extracted counts, using one-point arterial sampling whole blood counts by performing correction using the 5:29 ratio. (K.H.)

Biology Division progress report, October 1, 1984-September 30, 1985

Energy Technology Data Exchange (ETDEWEB)

1986-01-01

The body of this report provides summaries of the aims, scope and progress of the research by groups of investigators in the Division during the period of October 1, 1984, through September 30, 1985. At the end of each summary is a list of publications covering the same period. For convenience, the summaries are assembled under Sections in accordance with the current organizational structure of the Biology Division; each Section begins with an overview. It will be apparent, however, tha crosscurrents run throughout the Division and that the various programs support and interact with each other. In addition, this report includes information on the Division's educational activities, Advisory Committee, seminar program, and international interactions, as well as extramural activities of staff members, abstracts for technical meetings, and funding and personnel levels.

Biology Division progress report, October 1, 1984-September 30, 1985

International Nuclear Information System (INIS)

1986-01-01

The body of this report provides summaries of the aims, scope and progress of the research by groups of investigators in the Division during the period of October 1, 1984, through September 30, 1985. At the end of each summary is a list of publications covering the same period. For convenience, the summaries are assembled under Sections in accordance with the current organizational structure of the Biology Division; each Section begins with an overview. It will be apparent, however, tha crosscurrents run throughout the Division and that the various programs support and interact with each other. In addition, this report includes information on the Division's educational activities, Advisory Committee, seminar program, and international interactions, as well as extramural activities of staff members, abstracts for technical meetings, and funding and personnel levels

CERN Technical Training 2006: LabVIEW Course Sessions (September-December 2006)

CERN Multimedia

2006-01-01

The following LabVIEW course sessions are currently scheduled in the framework of the CERN Technical Training Programme 2006, and in collaboration with National Instruments (CH): LabVIEW Basics 1 (course in English): 11-13.9.2006 (3 days, only 3 places available) (course in English): 14-15.9.2006 (2 days) LabVIEW: Working efficiently with LabVIEW 8 (course in English): 18.9.2006 (1 day) **NEW COURSE** LabVIEW Application Development (course in English): 13-15.11.2006 (3 days. Pre-requisite: LabVIEW Basics I ans II, or equivalent experience) LabVIEW Advanced Programming (course in English): 16-17.11.2006 (2 days. Pre-requisite: LabVIEW Application Development, or equivalent experience) LabVIEW Base 1 (course in French): 4-6.12.2006 (3 days, only 1 place available) LabVIEW Base 2 (course in French): 7-8.12.2006 (2 days) If you are interested in attending any of the above course sessions, please discuss with your supervisor and/or your DTO,...

Gaz de France. 2006 reference document; Gaz de France. Document de reference 2006

Energy Technology Data Exchange (ETDEWEB)

NONE

2006-07-01

This document was issued by Gaz de France, the French gas utility, at the occasion of the opening of the capital of the company. It is intended to shareholders and presents the relevant informations relative to the annual consolidated financial statements of the group according to IFRS and French standards for the year 2005 (selected financial information, business overview, liquidity and capital resources, profit forecasts or estimates, compensation and benefits, issuer assets etc..). It includes also some complementary information about the activities of the group, its estate property, plants and equipments, its R and D and patenting activities, its management and administration, its 2005 and 2006 contracts etc.. (J.S.)

Small business innovation research: Abstracts of 1984. Phase 1 awards

Science.gov (United States)

1985-01-01

On September 27, 1984, the National Aeronautics and Space Administration announced the selection of Phase I projects for the Small Business Innovation Research Program. These awards resulted from the evaluation of proposals submitted in response to the 1984 Program Solicitation, SBIR 84-1. In order to make available information on the technical content of the Phase I projects supported by the NASA SBIR Program, the abstracts of those proposals which resulted in awards of contracts are given. In addition, the name and address of the firm performing the work are given for those who may desired additional information about the project. Propulsion, aerodynamics, computer techniques, exobiology and composite materials are among the areas covered.

KWL annual report 1984

International Nuclear Information System (INIS)

1985-01-01

The application for decommissioning the Lingen reactor has been filed on June 13, 1983. Response by the competent authority is expected to come in by mid-1985 at the earliest. At the beginning of 1985, preparatory work for the decommissioning phase has been started in the reactor containment, as e.g. removal of fuel elements, blow out of primary cooling circuit and evacuation of fuel storage pond. The number of personnel working at KWL reactor has been reduced to 108 in the period under review. The annual report 1984 has been worked out according to legal provisions; the profit and loss account is balanced at DM 35,43 millions. (orig./HSCH) [de

Survey of gaseous air pollutants at selected UK sites: XXI. Data digest for Cromwell Road, London, 1984

Energy Technology Data Exchange (ETDEWEB)

Broughton, G.F.J.; Bower, J.; Drury, V.J.; Lilley, K.; Powell, K.

1987-01-01

Ambient air-quality measurements of four gaseous pollutants plus black smoke and particulate lead continued during 1984 at the Cromwell Road kerbside site sponsored by the Department of the Environment. These data are presented here in the form of frequency distributions, averages, and other parameters for winter, summer, annual and monthly periods. Time-series graphs of pollutant concentrations for 1984 and of the historical data base between March 1973 and December 1984 are also included.

GeNF - Experimental report 2006

International Nuclear Information System (INIS)

Pranzas, P.K.; Schreyer, A.; Willumeit, R.

2007-01-01

At the Geesthacht Neutron Facility GeNF about 212 experiments were performed in 2006 by GKSS and by or for external users, partners or contractors. In most cases the measurements were performed and analysed in cooperation by the guests and by the GKSS staff or by the permanent external user group staff. The activities, which are based on a proposal procedure and on the in house R and D program, are reported in 71 contributions in the present annual experimental report for the year 2006. The contributions may contain one or also several combined experiments. During 2006 the GKSS research reactor FRG-1 achieved an operation time of 197 days at the full 5 MW reactor power providing a neutron flux of ca. 1.4 x 10 14 thermal neutrons/cm 2 s. The cold neutron source was available during the complete operation time. The focus of the in house R and D work at GeNF instruments was the characterisation of nanostructures in engineering materials, the analysis of stresses and textures in welds and technical structures at ARES-2, TEX-2, DCD and SANS-2, the structural investigation of hydrogen containing substances such as polymers, colloids and biological macromolecules at SANS-1 as well as the characterisation of magnetic thin films at PNR, NeRo, POLDI and ROeDI. The thoroughly upgraded residual stress diffractomer ARES-2 went in full operation in spring 2006 as well as the new neutron tomography device at GENRA-3. The installation of modern experiment control hardware and software based on LabView was completed on all designated instruments. In the appendices I and II the experimental reports of REFSANS at FRM II are attached as well as of the GKSS outstation HARWI-II at DESY. Both instruments started full operation in 2006. (orig.)

GeNF - Experimental report 2006

Energy Technology Data Exchange (ETDEWEB)

Pranzas, P K; Schreyer, A; Willumeit, R [GKSS-Forschungszentrum Geesthacht GmbH (Germany). Inst. of Materials Research

2007-07-01

At the Geesthacht Neutron Facility GeNF about 212 experiments were performed in 2006 by GKSS and by or for external users, partners or contractors. In most cases the measurements were performed and analysed in cooperation by the guests and by the GKSS staff or by the permanent external user group staff. The activities, which are based on a proposal procedure and on the in house R and D program, are reported in 71 contributions in the present annual experimental report for the year 2006. The contributions may contain one or also several combined experiments. During 2006 the GKSS research reactor FRG-1 achieved an operation time of 197 days at the full 5 MW reactor power providing a neutron flux of ca. 1.4 x 10{sup 14} thermal neutrons/cm{sup 2}s. The cold neutron source was available during the complete operation time. The focus of the in house R and D work at GeNF instruments was the characterisation of nanostructures in engineering materials, the analysis of stresses and textures in welds and technical structures at ARES-2, TEX-2, DCD and SANS-2, the structural investigation of hydrogen containing substances such as polymers, colloids and biological macromolecules at SANS-1 as well as the characterisation of magnetic thin films at PNR, NeRo, POLDI and ROeDI. The thoroughly upgraded residual stress diffractomer ARES-2 went in full operation in spring 2006 as well as the new neutron tomography device at GENRA-3. The installation of modern experiment control hardware and software based on LabView was completed on all designated instruments. In the appendices I and II the experimental reports of REFSANS at FRM II are attached as well as of the GKSS outstation HARWI-II at DESY. Both instruments started full operation in 2006. (orig.)

The Impact of Regulation 561/2006 on Fleet Management Viewed through Efficient Use of Drivers' Working Time

Directory of Open Access Journals (Sweden)

Robert Muha

2009-01-01

Full Text Available The introduction of contemporary procedures to fleet managementprocesses has recently changed the work planning andsupervision of driver's work activities. Tendencies to control theimplementation of driver's work have been present in modemprofessional practice for quite a long time; however, the equipmentavailable on the market limited its implementation. Theintensified development of digital tachographs has, in technicalterms, ensured such equipment considerably before the legislativegroundwork was prepared for its practical implementation.The Commission Regulation (EC No. 561!2006 (implementationof Social legislation relating to Road Transport does notbring any essential novelties in terms of permitted workload.Consistent monitoring of drivers activities, made possible bydigital tachographs, will have impact on the existing workingmethods. The topic of the present paper is in deep analysis ofthe impact of the mentioned regulation with special emphasison the conditions for the regulation of the current stage of driverswork and on the expected consequences. The essential imp011ancelies on the expected change in the mentality and approachto planning the driver's activities in the transport processon the part of the ea n·ier: the outcome will eventually resultin the efficiency of each individual canier.

Measurements of mesospheric water vapor in 1984 and 1985 - Results and implications for middle atmospheric transport

Science.gov (United States)

Bevilacqua, Richard M.; Schwartz, Philip R.; Wilson, William J.

1987-01-01

The detailed results of ground-based mesospheric water vapor measurements obtained by microwave spectroscopy at the Jet Propulsion Laboratory (JPL) from December 1984 to April 1985 (JPL 1984/85), and an overview of results obtained the previous year from April to June 1984 are presented. The JPL 1984/85 spectral data appeared to contain an instrumental baseline curvature which was bracketed and removed. In general, the JPL 1984/85 results are in good agreement with those of previous measurements. They indicate water vapor mixing ratios between 6 and 8 ppmv at 60 or 65 km and falling off steeply with height above this point to values of less than 2 ppmv at 80 km. In addition, there is a large amount of day-to-day variability indicated in the data. A major result of the study is that it is found that both the observed vertical gradient of water vapor mixing ratio and its seasonal variation are consistent with the hypothesis that vertical transport time scales are smaller, perhaps by an order of magnitude, than values currently used in both one- and two-dimensional photochemical/dynamical models.

Alferes Gamboa e a Sociedade Comemorativa da Independência do Império, 1869-1889

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Hendrik Kraay

2011-01-01

Full Text Available As festas da Independência brasileira promovidas pela Sociedade Comemorativa da Independência do Império no Rio de Janeiro revelam um significativo engajamento popular com o Estado imperial. O controle dessas celebrações pelo 'povo' da capital do Brasil aos poucos chegou a preocupar tanto membros da elite - perturbados diante do controle dos símbolos nacionais como a estátua equestre de d. Pedro I por patriotas populares - como republicanos que rejeitavam a monarquia, pois os patriotas populares demonstraram um monarquismo preocupante. Depois da morte do fundador e principal líder da Sociedade, em 1886, um grupo de homens estreitamente associado ao governo conservador tomou o seu controle e tentou impor celebrações convenientes e disciplinadas.

The Culture of Violence in the Final Phase of the Apartheid: South Africa c. 1984-1994

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Hilda Varela Barraza

2014-05-01

Full Text Available Since the 1970s, an organic crisis of the apartheid system began in South Africa, and it intensified in the beginning of the 1980s with the explosion of a new popular revolt, known as the township revolt. This article deals with a time period of approximately one decade (c. 1984-1994, characterized by a qualitative change in the culture of violence, which began in September 1984 but was triggered by the 1983 constitutional referendum and which symbolically ended with the first democratic election of 1984.

First half 2006 financial results

International Nuclear Information System (INIS)

2006-09-01

Areva provides technological solutions for highly reliable nuclear power generation and electricity transmission and distribution. The group is the world leader in nuclear power and the only company to cover all industrial activities in this field. This Press release presents the first half 2006 financial results: the overall performance and the performance by division (front end, reactors and services, back end, transmission and distribution). (A.L.B.)

The 1984 eclipse of the symbiotic binary SY Muscae

Science.gov (United States)

Kenyon, S. J.; Michalitisianos, A. G.; Lutz, J. H.; Kafatos, M.

1985-01-01

Data from IUE spectra obtained with the 10 x 20-arcsec aperture on May 13, 1984, and optical spectrophotometry obtained with an SIT vidicon on the 1.5-m telescope at CTIO on April 29-May 1, 1984, are reported for the symbiotic binary SY Mus. The data are found to be consistent with a model of a red-giant secondary of 60 solar radii which completely eclipses the hot primary every 627 d but only partially eclipses the 75-solar-radius He(+) region surrounding the primary. The distance to SY Mus is estimated as 1.3 kpc. It is suggested that the large Balmer decrement in eclipse, with (H-alpha)/(H-beta) = 8.3 and (H-beta)/(H-gamma) = 1.5, is associated with an electron density of about 10 to the 10th/cu cm.

Bibliographie 2006-2007

Directory of Open Access Journals (Sweden)

Florence Klein

2007-12-01

Full Text Available 1. Histoire, genres et théories littérairesArrighetti, G. (2006, Poesia, poetiche e storia nella riflessione dei greci. Studi, Giardini, Pisa (Biblioteca di studi antichi 89.Asmis, E. (2006 « Epicurean poetics » in A. Laird (éd., Ancient literary criticism. (Oxford Readings in Classical Studies. Oxford : Oxford UP, p. 238-266.Ax, W. (2006 Text und Stil. Studien zur antiken Literatur und deren Rezeption ; Stuttgart, Steiner. Batstone, W. W. (2006 « Provocation : The Point of Reception T...

The Agency's Technical Co-operation activities in 1984. Report by the Director General

International Nuclear Information System (INIS)

1985-08-01

The year 1984 can be described as one during which efforts were made to increase momentum in the development co-operation between the Agency and its Member States while continuing to improve the quality of the technical assistance rendered. For the first time, the adjusted programme exceeded $50 million. During the year, changes were introduced in the administration of the programme in line with recommendations endorsed by the Board in 1983 at the end of its first technical co-operation policy review. In 1984, when the new technical co-operation policies were applied, there were three principal aims. First, the flow of Technical Assistance and Co-operation Fund resources was to be improved; by decreasing accumulated unobligated balances, an optimum level of resource utilization was to be attained by 1986. Second, procedures for the procurement of goods and services were to be streamlined in order to permit substantial increases in programme delivery. Third, systematic project evaluation was to lead to a number of specific actions that would increase the effectiveness of the Agency's development assistance. With regard to the first aim, implementation increased by 44% over the 1983 level, passing the $30 million mark in October and reaching $36.6 million by the end of the year. Of this amount, $31.8 million related to the implementation of activities programmed for 1984. Therefore, an increase in total resources of only 4% was accompanied by an increase in current-year implementation of 34%. As a result, the upward trend in the unobligated balance was checked, and earmarkings against the TACF actually decreased. The implementation rate against the TACF rose from 58% in 1983 to 65% in 1984, reaching the level that had been set as a target. If this performance can be maintained in 1985, it will be possible to reach the optimum level of TACF resource utilization one year earlier than originally expected. As regards the second aim, streamlined procedures introduced in

IPEN scientific and technical publications 1984-1986

International Nuclear Information System (INIS)

1988-01-01

The Instituto de Pesquisas Energeticas e Nucleares - IPEN (Energy Research Institute) from Sao Paulo, Brazil, was founded in 1956. Since its foundation, the main objectives of IPEN has been to undertake research and development into the peaceful uses of nuclear energy and to train scientific personnel to post-graduate level. The IPEN Scientific and Technical Publication - IPEN/STP, is a system developed at IPEN. Its purpose has been to generate a data base identifying the technical and scientific literature produced by IPEN staff members, published either in the Institute's series or in others brazilian and foreign publications. Documents cited in this 1984-1986 supplement include those in which IPEN staff members were authors or co-authors; document published by foreign research visitors while working at IPEN facilities; theses prepared by IPEN staff and reports in which IPEN is a corporate author. The IPEN technical publications reflect the main fields of research persuaded by the Institute, namely nuclear physics radiochemistry, chemical engineering, nuclear metallurgy and engineering and finally medical and industrial applications of radioisotopes. In this 1984-1986 supplement 458 document published by IPEN staff are cited, following the main subject heading of INIS Subject Categories. (author)

Biomass Thermochemical Conversion Program. 1984 annual report

Energy Technology Data Exchange (ETDEWEB)

Schiefelbein, G.F.; Stevens, D.J.; Gerber, M.A.

1985-01-01

The objective of the program is to generate scientific data and conversion process information that will lead to establishment of cost-effective process for converting biomass resources into clean fuels. The goal of the program is to develop the data base for biomass thermal conversion by investigating the fundamental aspects of conversion technologies and by exploring those parameters that are critical to the conversion processes. The research activities can be divided into: (1) gasification technology; (2) liquid fuels technology; (3) direct combustion technology; and (4) program support activities. These activities are described in detail in this report. Outstanding accomplishments during fiscal year 1984 include: (1) successful operation of 3-MW combustor/gas turbine system; (2) successful extended term operation of an indirectly heated, dual bed gasifier for producing medium-Btu gas; (3) determination that oxygen requirements for medium-Btu gasification of biomass in a pressurized, fluidized bed gasifier are low; (4) established interdependence of temperature and residence times on biomass pyrolysis oil yields; and (5) determination of preliminary technical feasibility of thermally gasifying high moisture biomass feedstocks. A bibliography of 1984 publications is included. 26 figs., 1 tab.

A Survey of Archaeological Samples Dated in 1984

DEFF Research Database (Denmark)

Mejdahl, Vagn

A survey is given of archaeological samples dated in 1984 at the Nordic Laboratory for Thermoluminescence Dating. A total of 79 samples were dated, 49 of which were burnt stones. All results were corrected for fading as measured for samples stored for four weeks at room temperature. The alpha dose...

Citation Analysis of Skinner's "Verbal Behavior:" 1984-2004

Science.gov (United States)

Dymond, S.; O'Hora, D.; Whelan, R.; O'Donovan, A.

2006-01-01

The present study undertook an updated citation analysis of Skinner's (1957) "Verbal Behavior". All articles that cited "Verbal Behavior" between 1984 and 2004 were recorded and content analyzed into one of five categories; four empirical and one nonempirical. Of the empirical categories, studies that employed a verbal operant from Skinner's…

Die boek Job as bron van intertekste vir ‘Wie weet?' (Die waarheid gelieg, 1984

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E. Botha

1995-05-01

Full Text Available The Book of Job as a source of intertexts for T.T. Cloete’s short story ‘Wie weet?’ (Die waarheid gelieg, 1984 T.T. Cloete’s account of a woman's physical and spiritual agony in the short story “Wie weet?” ffrom Die waarheid gelieg, 1984, read within the South African/Afrikaans cultural context, presents several indicators that the Book of Job is its intertext, the most explicit pointer being the role of the sufferer’s sister-in-law. Intertextuality in Cloete’s oeuvre often takes the form of a creative reworking or rereading of texts (cf Scholtz, 1984; Botha, 1984; Roos, 1986. Roos comments on the caricatural treatment of theme in Cloete’s “Veg om te verloor” (Cloete, 1984, highlighted by the rereading imposed on the reader of Van Melle’s well-known story "Die joiner”, creating distrust in the implicit author of the Cloete text. The argument in this essay is that the explicit engagement of the intertext, as in "Wie weet?”, also serves as an affirmative complement to the negative incompleteness of the rereading. Thus the desperate questioning of "Wie weet?” becomes an integral part of a reading of Cloete’s oeuvre as a hymn to God’s omnipotence and mercy, epitomized in the poem "Van Horn en my” (Jukstaposisie, 1982.

Works made by the working group on the division by four by 2050 of France's greenhouse gas emissions, named 'factor 4'. January 19, 2006 meeting

International Nuclear Information System (INIS)

2006-01-01

A working group was created on September 8, 2005 by the French minister of ecology and sustainable development and the French minister of industry with the aim of exploring all possible paths allowing to reach the long term goal of dividing by a factor 4 the French greenhouse gas emissions from now to 2050. This paper gathers the transparencies of three presentations given at the January 19, 2006 meeting of the 'Factor 4' working group: behaviour of energy consumers; which public policies to reach the factor 4; macro-economics of the factor 4. (J.S.)

Cognitive Function and Brain Atrophy Predict Non-pharmacological Efficacy in Dementia: The Mihama-Kiho Scan Project2

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Ken-ichi Tabei

2018-04-01

Full Text Available We aimed to determine whether neuropsychological deficits and brain atrophy could predict the efficacy of non-pharmacological interventions. Forty-six participants with mild-to-moderate dementia were monitored for 6 months; 25 underwent an intervention involving physical exercise with music, and 21 performed cognitive stimulation tasks. Participants were categorized into improvement (IMP and no-IMP subgroups. In the exercise-with-music group, the no-IMP subgroup performed worse than the IMP subgroup on the Rivermead Behavioural Memory Test at baseline. In the cognitive-stimulation group, the no-IMP subgroup performed worse than the IMP subgroup on Raven’s Colored Progressive Matrices and the cognitive functional independence measure at baseline. In the no-IMP subgroup, voxel-based morphometric analysis at baseline revealed more extensive gray matter loss in the anterior cingulate gyrus and left middle frontal gyrus in the exercise-with-music and cognitive-stimulation groups, respectively. Participants with mild-to-moderate dementia with cognitive decline and extensive cortical atrophy are less likely to show improved cognitive function after non-pharmaceutical therapy.

Cognitive Function and Brain Atrophy Predict Non-pharmacological Efficacy in Dementia: The Mihama-Kiho Scan Project2.

Science.gov (United States)

Tabei, Ken-Ichi; Satoh, Masayuki; Ogawa, Jun-Ichi; Tokita, Tomoko; Nakaguchi, Noriko; Nakao, Koji; Kida, Hirotaka; Tomimoto, Hidekazu

2018-01-01

We aimed to determine whether neuropsychological deficits and brain atrophy could predict the efficacy of non-pharmacological interventions. Forty-six participants with mild-to-moderate dementia were monitored for 6 months; 25 underwent an intervention involving physical exercise with music, and 21 performed cognitive stimulation tasks. Participants were categorized into improvement (IMP) and no-IMP subgroups. In the exercise-with-music group, the no-IMP subgroup performed worse than the IMP subgroup on the Rivermead Behavioural Memory Test at baseline. In the cognitive-stimulation group, the no-IMP subgroup performed worse than the IMP subgroup on Raven's Colored Progressive Matrices and the cognitive functional independence measure at baseline. In the no-IMP subgroup, voxel-based morphometric analysis at baseline revealed more extensive gray matter loss in the anterior cingulate gyrus and left middle frontal gyrus in the exercise-with-music and cognitive-stimulation groups, respectively. Participants with mild-to-moderate dementia with cognitive decline and extensive cortical atrophy are less likely to show improved cognitive function after non-pharmaceutical therapy.

Information from the HR Department for members of the personnel residing in FRANCE

CERN Document Server

HR Department

2007-01-01

Tax assessment notice sent by the French Tax Centre Members of the personnel residing in France have received (or are about to receive) a document issued by their local Centre des Impôts (CDI) entitled «Avis d’impôt – IMPÔT SUR LES REVENUS DE 2006». The document states in particular that: «La déclaration que vous avez déposée ne comporte aucun revenu pour l’année 2006. Je vous informe que le présent avis ne constitue pas un justificatif d’absence de tout revenu. Vous avez perçu des revenus en provenance d’organismes internationaux, de missions diplomatiques ou consulaires exonérés d’impôt en France. Indiquez-les au bas de cet avis» [1] This document must not be returned to your CDI. However, you must keep it as the French authorities may ask you to produce it as evidence of your tax position in France. Further information may be obtained directly from your CDI. HR DepartmentTel: 73903 [1] CERN translation, for information only: "The declaration...

Single photon emission computed tomography (SPECT) findings using N-isopropyl-p-[[sup 123]I]iodoamphetamine ([sup 123]I-IMP) in schizophrenia and atypical psychosis

Energy Technology Data Exchange (ETDEWEB)

Suga, Hidemichi (Aichi Medical Univ., Nagakute (Japan))

1993-05-01

Sixteen schizophrenic patients, 16 atypical psychosis patients, and 16 healthy volunteers were subjected to single photon emission computed tomography (SPECT) of the brain using N-isopropyl-p-[[sup 123]I]iodoamphetamine ([sup 123]I-IMP). The basal ganglia region was in particular examined not only in transverse sections, but in coronal sections. Schizophrenics showed significantly decreased uptake rates in the bilateral frontal regions and increased uptakes in the bilateral basal ganglia. On the other hand, atypical psychotics had a reduced uptake rate only in the right thalamic region, compared to the controls. The increased uptake rates in the basal ganglia were associated with auditory hallucination, but gender difference, duration of illness and dose of neuroleptics had no influence on these SPECT findings. The results suggest that schizophrenics might have some lesions in the frontal area of the brain, whereas atypical psychotics might have no lesion in the frontal region but dysfunction in the right thalamic region. Subsequently, using only SPECT findings, all the cases were divided by cluster analysis into 4 groups and a residue group. Schizophrenics distributed mainly in the 2 groups that have lesion in the frontal regions. Atypical psychotics distributed principally in the other 2 groups that have alterations in the bilateral thalamic region. The present study suggests that schizophrenia and atypical psychosis might have different etiologies. (author).

Annual report 1984 of Hauptabteilung Sicherheit

International Nuclear Information System (INIS)

Kiefer, H.; Koelzer, W.; Koenig, L.A.

1985-04-01

The Safety Officer and the Security Officer are responsible for radiation protection and technical safety, both conventional and nuclear, for the physical protection as well as the safeguards of nuclear materials and radioactive substances within the Kernforschungszentrum Karlsruhe GmbH (KfK). To fulfill these functions they rely on the assistance of the Central Safety Department. The Central Safety Department is responsible for handling all problems of radiation protection, safety and security of the institutes and departments of the Karlsruhe Nuclear Research Center, for waste water activity measurements and environmental monitoring of the whole area of the Center, and for research and development work mainly focusing on nuclear safety and radiation protection measures. The r+d work concentrates on the following aspects: atmospheric diffusion of nuclear pollutants, physical and chemical behavior of biologically particularly active radionuclides, microbiological influence on the behavior of radionuclides in soils and sediments, improvement in radiation protection measurement and personnel dosimetry. This report gives details of the different duties, indicates the results of 1984 routine tasks and reports about results of investigations and developments of the working groups of the Department. The reader is referred to the English translation of the Table of Contents and of Chapter 1 describing the duties and organization of the Central Safety Department. (orig.) [de

Technical Cooperation Report for 2006. Report by the Director General. Supplement

International Nuclear Information System (INIS)

2007-07-01

The following pages contain financial and statistical data that supplement the Technical Cooperation Report for 2006. Again this year, the information is grouped under three headings, which allow the reader to view comprehensively the data for each area of activity. The countries are grouped by TC programme region in most of the tables. An alphabetical listing by region of all the countries/territories are mentioned in this report. Montenegro declared independence from Serbia on 3 June 2006. After that date, the IAEA Membership of the former Serbia and Montenegro was continued by the Republic of Serbia. For its part, Montenegro became a Member of the IAEA on 30 October 2006. The information in the tables concerning these Member States reflects assistance and contributions over the course of the full year 2006. Unless otherwise specified, all amounts are expressed in United States dollars. As most figures are rounded to thousands of US dollars, the amounts in tables may not add up exactly to the totals shown due to rounding

A simple method for measurement of cerebral blood flow using 123I-IMP SPECT with calibrated standard input function by one point blood sampling. Validation of calibration by one point venous blood sampling as a substitute for arterial blood sampling

International Nuclear Information System (INIS)

Ito, Hiroshi; Akaizawa, Takashi; Goto, Ryoui

1994-01-01

In a simplified method for measurement of cerebral blood flow using one 123 I-IMP SPECT scan and one point arterial blood sampling (Autoradiography method), input function is obtained by calibrating a standard input function by one point arterial blood sampling. A purpose of this study is validation of calibration by one point venous blood sampling as a substitute for one point arterial blood sampling. After intravenous infusion of 123 I-IMP, frequent arterial and venous blood sampling were simultaneously performed on 12 patients of CNS disease without any heart and lung disease and 5 normal volunteers. The radioactivity ratio of venous whole blood which obtained from cutaneous cubital vein to arterial whole blood were 0.76±0.08, 0.80±0.05, 0.81±0.06, 0.83±0.11 at 10, 20, 30, 50 min after 123 I-IMP infusion, respectively. The venous blood radioactivities were always 20% lower than those of arterial blood radioactivity during 50 min. However, the ratio which obtained from cutaneous dorsal hand vein to artery were 0.93±0.02, 0.94±0.05, 0.98±0.04, 0.98±0.03, at 10, 20, 30, 50 min after 123 I-IMP infusion, respectively. The venous blood radioactivity was consistent with artery. These indicate that arterio-venous difference of radioactivity in a peripheral cutaneous vein like a dorsal hand vein is minimal due to arteriovenous shunt in palm. Therefore, a substitution by blood sampling from cutaneous dorsal hand vein for artery will be possible. Optimized time for venous blood sampling evaluated by error analysis was 20 min after 123 I-IMP infusion, which is 10 min later than that of arterial blood sampling. (author)

Three-dimensional surface display of brain perfusion with 123I-IMP in Parkinson's disease

International Nuclear Information System (INIS)

Tachibana, H.; Kawabata, K.; Tomino, Y.; Sugita, M.; Fukuchi, M.

1994-01-01

We reconstructed three-dimensional (3D) surface images from single-photon emission computed tomography (SPECT) data using N-isopropyl-p[ 123 I]-iodoamphetamine ( 123 I-IMP) in 27 patients with Parkinson's disease and 11 normal control subjects. The 3D reconstruction was performed using distance-shaded methods at threshold levels with an interval of 5% from 45-80%. Any area of decreased perfusion at each threshold level was visualised as a defect area by the algorithm. In nondemented patients with Parkinson's disease, perfusion defects were frequently found in the parietal cortex at a threshold value of 65%. In demented patients, perfusion defects were frequently seen at thresholds of 45-65%, and were more marked in the temporal and parietal cortex bilaterally. This suggests that dementia in Parkinson's disease is related to a reduction of perfusion in the temporoparietal cortex. (orig.)

Computers and Reading: 1984-1989. Selections from "Micro Missive," the Newsletter of MicroSIG, The Special Interest Group for Microcomputers in Reading of the International Reading Association.

Science.gov (United States)

Balajthy, Ernest

This publication is a collection of eight articles and ten software reviews written by the author for "Micro Missive" since 1984. "Micro Missive" is a quarterly newsletter that has regularly informed International Reading Association members of new developments in computer-based instruction and reading/language arts through articles, software…

1982-1984 Eclipse of Epsilon Aurigae

International Nuclear Information System (INIS)

Stencel, R.E.

1985-09-01

A workshop proceedings concerned with the new data collected during the 1982-1984 eclipse period of the 27-year system Epsilon Aurigae is presented. This binary star has been a classic problem in astrophysics because the opaque eclipsing object is nonstellar, and probably disk shaped. Invited papers concerning the history of the system, optical, infrared and ultraviolet photometry, optical polarimetry and ultraviolet spectroscopy are included. An invited paper concerning comprehensive theoretical interpretation in the context of stellar evolution also is included

RECENT REFERENCES: JULY 1, 2006 TO SEPTEMBER 30, 2006

Energy Technology Data Exchange (ETDEWEB)

WINCHELL, D.F.

2006-09-30

This document lists experimental references added to Nuclear Science References (NSR) during the period July 1, 2006 to September 30, 2006. The first section lists keynumbers and keywords sorted by mass and nuclide. The second section lists all references, ordered by keynumber.

Meie tipud 2006 : ¡Eesti kirjanduskriitika artikliauhinnast 2006. aastal / Linnar Priimägi

Index Scriptorium Estoniae

Priimägi, Linnar, 1954-

2007-01-01

Eesti kirjanduskriitika 2006. aasta artikliauhinna neljast nominendist Anne Lillest (Antiiktragöödia, esteetika paradoksid ja Mati Unt. Keel ja Kirjandus 2006, nr. 6), Toomas Haugist (A. H. T. surm Aafrikas. Lisandusi Leo Frobeniuse "Jumala külalise" kadunud tõlkele. Looming 2006, nr. 6), Märt Väljatagast (Orja teadvus varjus ja valguses. Looming 2006, nr. 12) ja Eneken Laanesest (Mäletamise lühis: Ene Mihkelsoni "Ahasveeruse uni". Keel ja Kirjandus 2006, nr. 6)

La copla de moral sefardí Azote de impíos

Directory of Open Access Journals (Sweden)

Romero, Elena

2010-06-01

Full Text Available Three versions of the Sephardic “Copla de moral” Azote de Impios (‘Scourge of the Wicked’ are analyzed in this article. They were all printed in the nineteenth century, in Constantinople (1858 (version A, in Leipzig (1858 (version B and in Jerusalem (1894 (version C. The Version B was included in the German Nach Jerusalem! by Ludwig Aug. Frankl is of interest as it was written with Latin letters according to a special system that reflects the sounds of the original Judeo-Spanish.En el presente artículo se lleva a cabo la edición y estudio de las tres versiones conocidas de la copla de moral sefardí titulada Azote de impíos, impresas las dos primeras en 1858 en Constantinopla (versión A y Leipzig (versión B, respectivamente, y la tercera en Jerusalén en 1894 (versión C. La versión B, inserta en el libro alemán Nach Jerusalem! de Ludwig Aug. Frankl, presenta la particularidad de estar escrita en caracteres latinos siguiendo un muy especial sistema para plasmar los sonidos del judeoespañol.

Orwell's 1984: Natural Language Searching and the Contemporary Metaphor.

Science.gov (United States)

Dadlez, Eva M.

1984-01-01

Describes a natural language searching strategy for retrieving current material which has bearing on George Orwell's "1984," and identifies four main themes (technology, authoritarianism, press and psychological/linguistic implications of surveillance, political oppression) which have emerged from cross-database searches of the "Big…

Pseudomonas aeruginosa-producing Metallo-β-lactamases (VIM, IMP, SME, and AIM) in the Clinical Isolates of Intensive Care Units, a University Hospital in Isfahan, Iran.

Science.gov (United States)

Khorvash, Farzin; Yazdani, Mohammadreza; Shabani, Shiva; Soudi, Aliasghar

2017-01-01

Pseudomonas aeruginosa is a severe challenge for antimicrobial therapy, due to the chromosomal mutations or exhibition of intrinsic resistance to various antimicrobial agents such as most β-lactams. We undertook this study to evaluate the existence of SME, IMP, AIM, and VIM metallo-β-lactamases (MBL) encoding genes among P. aeruginosa strains isolated from Intensive Care Unit (ICU) patients in Al-Zahra Hospital in Isfahan, Iran. In a retrospective cross-sectional study that was conducted between March 2012 and April 2013, a total of 48 strains of P. aeruginosa were collected from clinical specimens of bedridden patients in ICU wards. Susceptibility test was performed by disc diffusion method. All of the meropenem-resistant strains were subjected to modified Hodge test for detection of carbapenemases. Multiplex polymerase chain reaction was performed for detection of blaVIM, blaIMP, blaAIM, and blaSME genes. In disk diffusion method, imipenem and meropenem showed the most and colistin the least resistant antimicrobial agents against P. aeruginosa strains. Of the 48 isolates, 36 (75%) were multidrug resistant (MDR). Amplification of β-lactamase genes showed the presence of blaVIM genes in 7 (%14.6) strains and blaIMP genes in 15 (31.3%) strains. All of the isolates were negative for blaSME and blaAIM genes. We could not find any statistically significant difference among the presence of this gene and MDR positive, age, or source of the specimen. As patients with infections caused by MBL-producing bacteria are at an intensified risk of treatment failure, fast determination of these organisms is necessary. Our findings may provide useful insights in replace of the appropriate antibiotics and may also prevent MBLs mediated resistance problem.

Pseudomonas aeruginosa-producing Metallo-β-lactamases (VIM, IMP, SME, and AIM in the Clinical Isolates of Intensive Care Units, a University Hospital in Isfahan, Iran

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Farzin Khorvash

2017-01-01

Full Text Available Background: Pseudomonas aeruginosa is a severe challenge for antimicrobial therapy, due to the chromosomal mutations or exhibition of intrinsic resistance to various antimicrobial agents such as most β-lactams. We undertook this study to evaluate the existence of SME, IMP, AIM, and VIM metallo-β-lactamases (MBL encoding genes among P. aeruginosa strains isolated from Intensive Care Unit (ICU patients in Al-Zahra Hospital in Isfahan, Iran. Materials and Methods: In a retrospective cross-sectional study that was conducted between March 2012 and April 2013, a total of 48 strains of P. aeruginosa were collected from clinical specimens of bedridden patients in ICU wards. Susceptibility test was performed by disc diffusion method. All of the meropenem-resistant strains were subjected to modified Hodge test for detection of carbapenemases. Multiplex polymerase chain reaction was performed for detection of blaVIM, blaIMP, blaAIM, and blaSME genes. Results: In disk diffusion method, imipenem and meropenem showed the most and colistin the least resistant antimicrobial agents against P. aeruginosa strains. Of the 48 isolates, 36 (75% were multidrug resistant (MDR. Amplification of β-lactamase genes showed the presence of blaVIM genes in 7 (%14.6 strains and blaIMP genes in 15 (31.3% strains. All of the isolates were negative for blaSME and blaAIM genes. We could not find any statistically significant difference among the presence of this gene and MDR positive, age, or source of the specimen. Conclusion: As patients with infections caused by MBL-producing bacteria are at an intensified risk of treatment failure, fast determination of these organisms is necessary. Our findings may provide useful insights in replace of the appropriate antibiotics and may also prevent MBLs mediated resistance problem.

Intervenciones olvidadas: Beatriz Sarlo en la universidad argentina de la posdictadura (1984-1986

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Analía Isabel Gerbaudo

2010-06-01

Full Text Available Este artículo se enmarca en una investigación sobre las intervenciones de los críticos que trabajaron como profesores en la universidad argentina durante la fase inicial de la posdictadura (1984-1986 en las áreas de literatura argentina y teoría literaria. El estudio se centra en sus programas de cátedra —documentos desatendidos tanto por la crítica como por la historia— en diálogo con sus ensayos y entrevistas. Esta presentación gira sobre el programa que en 1984 Beatriz Sarlo arma para la materia “Literatura argentina II” y precisa qué lectura inventa para dicha literatura en relación con la escritura latinoamericana, tanto literaria como crítica.This article is part of a research project about the policies carried out by critics who worked as University teachers in Argentina during the initial stage of the postdictatorial period (1984-1986 in the areas of Argentine Literature and Literary Theory. This project studies their class syllabi—documents which have been overlooked both by criticism and by history—in dialogue with their essays and interviews. This presentation deals with the syllabus which was presented by Beatriz Sarlo in 1984 for her class “Argentine Literature II”, and specifies how she reads that literature in relation with Latin American critical and literary writing.

The study of I-123-IMP-SPECT before and after surgery for craniosynostosis

International Nuclear Information System (INIS)

Satoh, Motohiro; Ishikawa, Nobuyoshi; Enomoto, Takao; Takeda, Tohru; Yoshizawa, Takashi; Nose, Tadao.

1990-01-01

Single photon emission computed tomography with N-isopropyl-p-[I-123]iodoamphetamine was performed in 13 cases of craniosynostosis before and after surgery. Of 13 cases, 8 cases (62%) showed focal low perfusion area on preoperative study. Four of seven cases (57%) with brachycephaly showed low perfusion areas in either of frontal lobes, occipital lobes, and cerebellum. Besides, two patients with scaphocephaly and one with plagiocephaly showed low perfusion area in the unilateral cerebral hemisphere. Two Crouzon disease cases showed no focal low perfusion area, but an Apert disease showed low perfusion areas in both frontal lobes, cerebellum, as well as left occipital lobe. Corresponding CT and MRI showed no focal abnormality in any of these cases. These low perfusion areas were diminished or disappeared after surgical treatment in 6 cases (75%). We conclude that the I-123-IMP-SPECT is considered to be a useful index for the evaluation of functional recovery after surgery in cases of craniosynostosis. (author)

Australian mineral industry annual review for 1984

Energy Technology Data Exchange (ETDEWEB)

1987-01-01

This volume of the Australian Mineral Industry Annual Review records development and performance of the Australian mineral industry during the calendar year 1984. It reports production, consumption, treatment, trade, prices, new developments, exploration, and resources for mineral commodities including fuels, and summarises equivalent developments abroad. Part 1. 'general review' after briefly surveying the world mineral industry, summarises developments in the Australian mineral industry as a whole, under the headings: the industry in the national economy, prices, exploration expenditure, investment, income tax, royalties, structural data, wages and salaries, industrial disputes, and government assistance, legislation, and controls. Part 2. 'commodity review' covers individual mineral commodity groups, from abrasives to zirconium. Part 3, 'mining census', tabulates statistics extracted from the mining census, together with some mineral processing statistics from the manufacturing census. Part 4 tabulates quantity and value data on mineral output provided by state departments of mines and their equivalents. Listed in appendices are: principal mineral producers; ore buyers and mineral dealers; government mining services; analytical laboratories; state mines departments and equivalents; industry, professional and development organisations and associations, etc; summary of mineral royalties payable in the states and territories; and summary of income tax provisions and federal government levies.

Summary of the Lavia borehole investications in 1984

International Nuclear Information System (INIS)

Aeikaes, T.; Oehberg, A.; Ryhaenen, V.

1985-02-01

Industrial Power Company Ltd (TVO) drilled in the spring 1984 a 1001 m deep borehole, diameter 56 mm, in Lavia. The borehole is used during the years 1984-85 for developing and testing research methods and equipment needed in site investigations of spent fuel final disposal in the future. In 1984 hydraulical and geophysical tests were made and groundwater samples were taken. The drilling site is a wide outcropped area in the northern part of the porphyritic granite formation of Lavia. Geological and fracture mapping as well as geophysical measurements on the surface were made in the area surrounding the drilling site. The bedrock consists of homonous porphyritic granite, in which quartzdiorite occurs in thin incalations. Magnetic or electric anomalies were not observed. Fracture frequency is low and the fractures appear mainly in two sets. The rock types vary in the borehole from porphyritic granite to diorite. Due to slight mineralogical variations, the diorite is either granodiorite, quartzdiorite or tonalite. Granite occurs as veins. Hydraulic conductivity was measured systematically with a packer separation of 30 m between the depths 73-973 m. Hydraulic conductivity is generally 10 -10 -10 -11 m/s. Electric, radiometric, magnetic and acoustic measurements were made in the borehole. In addition, the caliper and the temperature of the borehole were measured. The results of these geophysical measurements indicate the properties of rock types and fracturing in the borehole. On the basis of the results e.g. fracture porosity was interpreted. The results of acoustic tube wave measurement correlate well with hydraulic conductivity. Water samples were taken from four depths. The deepest level was 910 m. The samples were taken with a packer separation of 5 m. In the water analyses it was observed that at several depths remarkable amounts of flushing water from drilling were still remaining in the rock

"1984": How Much Fact in Fiction? [Lesson Plan].

Science.gov (United States)

Hedberg, Betsy