Immunizations: Active vs. Passive

Science.gov (United States)

... Issues Health Issues Health Issues Conditions Injuries & Emergencies Vaccine Preventable Diseases ... Children > Safety & Prevention > Immunizations > Immunizations: Active vs. Passive Safety & ...

Reputationsorientiertes Themen- und Issues-Management : Konzeption, Regelbetrieb, Weiterentwicklung

OpenAIRE

Fahrenbach, Christian

2011-01-01

Die Dissertation untersucht, wie Organisationen ein reputationsorientiertes Themen- und Issues-Management aufbauen, betreiben und weiterentwickeln können. Dazu wird das operative Modell des Issues Managements mit dem strategischen Zielkonstrukt Reputation verbunden. Zu Beginn der Arbeit beschreiben zwei Theorie-Kapitel ausführlich Relevanz und die Steuerung von Reputation und im Issues Management. Auf dieser Basis wird ein praxisorientiertes integriertes Modell entwickelt. Es beschreibt da...

Behavioral issues in operations management new trends in design, management, and methodologies

CERN Document Server

2013-01-01

Behavioral Operations Management  has been identified in the last years as one of the most promising emerging fields in Operations Management. Behavioral Issues in Operations Management  explains and examines up-to-date research in this field, which works to analyze the impact of human behavior on the management of complex operating systems.   A collection of studies from leading scholars presents different methodologies and approaches, supported by real data and case studies. Issues such as building trust and strong cooperative relationships with suppliers, enhancing motivation and designing proper incentives for stimulating more effective decision maker behaviours are considered. The main decision-making processes affected by behavioral issues are also analyzed with a focus on new product development, logistics, and supply chain integration.   The broad coverage of methodologies and practical implications makes Behavioral Issues in Operations Management an ideal reference for both researchers developing...

Issues for small businesses with waste management.

Science.gov (United States)

Redmond, Janice; Walker, Elizabeth; Wang, Calvin

2008-07-01

Participation by small and medium enterprise (SME) in corporate social responsibility issues has been found to be lacking. This is a critical issue, as individually SMEs may have little impact on the environment but their collective footprint is significant. The management style and ethical stance of the owner-manager affects business decision making and therefore has a direct impact on the environmental actions of the business. Although adoption of environmental practices to create competitive advantage has been advocated, many businesses see implementation as a cost which cannot be transferred to their customers. After a brief review of pertinent literature this paper reports on an exploratory investigation into the issue. Results show that whereas owner-managers of small enterprises express concern regarding the environment, this does not then translate into better waste management practices.

Comparison of immunization rates of adults ages 65 years and older managed within two nurse practitioner-owned clinics with national immunization rates.

Science.gov (United States)

Wright, Wendy L; Morrell, Elise; Lee, Jennie; Cuellar, Norma Graciela; White, Patricia

2017-07-01

Adults ages ≥65 years are at increased risk for infectious diseases. Ensuring these individuals are fully vaccinated is imperative. The purpose of this study was to assess the immunization rates of adults ages ≥65 years managed by nurse practitioners (NPs) and compare the results with national immunization rates and Healthy People 2020 goals. A convenience sample of adults ages ≥65 years was obtained from two NP-managed clinics. The vaccine records of each subject were reviewed for documentation of having received five vaccines (tetanus, diphtheria, and pertussis; influenza; pneumococcal polysaccharide vaccine 23; pneumococcal conjugate vaccine 13; and herpes zoster vaccine). One hundred and fifty females (70.8%) and 62 males (29.2%) met inclusion criteria. NP-managed patients had higher immunization rates than the national averages across all five major vaccines. The herpes zoster vaccination rates exceeded the recommendations from Healthy People 2020 whereas pneumococcal and influenza rates were below. The stocking of vaccines within the NP-managed clinics, direct billing to Medicare for Part D vaccines, and previsit care planning likely contributed to the high vaccination rates. These high immunization rates in patients managed by NPs provide support for the important role that NPs play in the care of older adults. ©2017 American Association of Nurse Practitioners.

The Major Players in Adaptive Immunity-Cell-mediated Immunity

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 14; Issue 6. The Major Players in Adaptive Immunity - Cell-mediated Immunity. Asma Ahmed Banishree Saha Anand Patwardhan Shwetha Shivaprasad Dipankar Nandi. General Article Volume 14 Issue 6 June 2009 pp 610-621 ...

Ethical issues faced by clinician/managers in resource-allocation decisions.

Science.gov (United States)

Lemieux-Charles, L; Meslin, E M; Aird, C; Baker, R; Leatt, P

1993-01-01

This article explores the ethical issues faced by clinicians with management responsibilities (clinician/managers) when making decisions related to resource allocation and utilization at a Canadian teaching hospital. Using a focus group method, 28 individuals participated in four homogeneous groups that included nurse managers, managers from other professional groups, and physician managers. Ethical issues that recurred throughout the discussions included fairness, concern with preventing harm, consumer/patient choice, balancing needs of different groups of patients, conflict between financial incentives and patient needs, and professional autonomy. The particular issue of conflict is analyzed from two perspectives--a theory of professional-bureaucratic roles and of obligation--that illustrate how both management and philosophical issues are related. The findings suggest that decentralizing resource allocation and utilization decisions does raise ethical issues for clinician/managers and that a better understanding of these issues can be obtained using an interdisciplinary perspective.

Issues and trends in radioactive waste management in Turkey

International Nuclear Information System (INIS)

Osmanlioglu, A.E.

2002-01-01

This paper focuses on issues associated with the waste management aspects of Turkey. Predisposal management of radioactive wastes covers a broad range of activities. This also includes waste identification, characterization and conditioning. Experience gained over years shows that current predisposal waste management practices are well advanced. The paper concludes these activities based on experience gained by CWPSF (CNAEM Waste Processing and Storage Facility) and includes issues and trends in radioactive waste management. In addition general information is presented on ongoing national projects and IAEA research projects on various issues of waste management. (author)

Using Online Databases in Corporate Issues Management.

Science.gov (United States)

Thomsen, Steven R.

1995-01-01

Finds that corporate public relations practitioners felt they were able, using online database and information services, to intercept issues earlier in the "issue cycle" and thus enable their organizations to develop more "proactionary" or "catalytic" issues management repose strategies. (SR)

Information Systems Management: an Australasian view of key issues - 1996

Directory of Open Access Journals (Sweden)

Graham Pervan

1997-11-01

Full Text Available As part of a longitudinal study of key information systems management issues, a survey of Australasia's largest 500 organisations was conducted to identify which issues were perceived by the IS executives as being important, problematic and critical over the next three to five years. The most critical issues were revealed to be a mix of technology management issues (IT infrastructure, communications, disaster recovery, strategic management issues (competitive advantage, IS planning, aligning the IS organisation, people management issues (organisational learning, educating senior management in IT, systems development and data management issues (effective use of the data resource, and end-user computing. This reflects the need for a balance of business, technical, and people skills in an IS executive. Non-critical issues were mostly related to systems development and the individual technologies which must be integrated and managed to ensure a responsive IT infrastructure. The study also reveals that some issues are much more important than problematic (disaster recovery, competitive advantage, information architecture, and IS alignment while others are much more problematic than important (end-user computing, IS role and contribution, and BPR. The former reflects a growing level of knowledge in handling these issues, while the latter reflects a continuing problem with them. The differences between this study and similar studies conducted in 1988 and 1992 show that there is a growing confidence in the IS executive's ability to manage the strategic issues, a continuing concern about providing a responsive IT infrastructure (especially communications, and a continuing concern with educating all 'customers' in the organisation in the effective use of IT, including senior management.

Clearing and vegetation management issues

International Nuclear Information System (INIS)

Anon.

1994-01-01

Clearing and continued management of incompatible plant species is critical to maintaining safe and reliable transmission and distribution lines at British Columbia Hydro. As part of a general review of policies regarding rights-of-way, the clearing of BC Hydro rights-of-way was studied by a task team in order to formulate a set of recommended policies and procedures to guide employees in all rights-of-way decisions, and to provide clear direction for resolution of all rights-of-way issues in a cost-effective manner. Issues reviewed were: clearing standards and line security standardization for transmission circuits; clearing rights for removal of trees or management of vegetation beyond the statutory right-of-way; clearing and vegetation management procedures; tree replacement; arboricultural techniques; periodic reviewing of clearing practices; compensation for tree removal; herbicide use; and heritage and wildlife trees. Justification for the recommendation is provided along with alternate options and costs of compliance

Waste management issues, a set of technologies

International Nuclear Information System (INIS)

Gautrot, J.J.

2000-01-01

As any other industry, nuclear fuel cycle back-end raises the major issue of waste management. In France, spent fuel is considered as valuable materials and only the ultimate waste are considered as actual waste. Accordingly, waste issue is as follows: a sorting out has to be done, in order to separate valuable materials from actual wastes, put any outlet flow under a stable form and condition them appropriately to their respective recycling or disposal routes. This implies the implementation of a comprehensive set of technologies. Actually, it is an industrial reality, as the COGEMA Group has for a long time set up a reprocessing and conditioning strategy in its plants. Waste management issues are common to many activities. European as well as French regulators already introduced the twofold necessity to reduce waste volumes, and to dispose of only ''ultimate waste'' as concerns industrial and household waste mainly. In this objective, French nuclear reprocessing and recycling industry may be seen as a breeding ground of well-proven technologies and management options. Actually, processes used can also give an answer to such different issues as excess plutonium immobilization, sites cleaning up (including for instance treatment of the liquid HLW legacy), dismantling wastes management. There are a number of operations to be dealt with worldwide that will find a solution in any of the technologies implemented and optimized in COGEMA facilities. Based on the COGEMA Group know-how, the present paper will describe those technologies and explain how they can solve the other stringent waste management issues worldwide. (author)

Steroid sparing regimens for management of oral immune-mediated diseases

Directory of Open Access Journals (Sweden)

Arti Agrawal

2014-01-01

Full Text Available Immune-mediated mucocutaneous disease may present oral symptoms as a first sign of the disease. The primary etiology could be the cellular and/or humoral immune responses directed against epithelial or connective tissue, in a chronic and recurrent pattern. Lichen planus, pemphigus vulgaris and bullous pemphigoid are the most frequent immunologically mediated mucocutaneous diseases. More often than not, patients present with complaints of blisters, oral ulcers, pain, burning sensation, and bleeding from the various oral sites. Steroids, whether topical or systemic, are the treatment of choice as they have both anti-inflammatory and immune-suppressant properties; however, challenges in the treatment of autoimmune diseases are the complexity of symptoms, the need to manage long-term medications for preserving organ function, and the long-term adverse effects of steroids. In such situations steroid sparing agents, such as, tacrolimus, dapsone, azathioprine, cyclosporine, and so on, may be helpful. Here an attempt is made to review various treatment regimens that could be used as alternatives to steroids for management of such diseases.

Information technology: management issues in outsource contracts.

OpenAIRE

2008-01-01

This study concerns the investigation of management issues within information technology outsourcing contracts. The information technology outsourcing life cycle is used as the flow structure for the investigation. The associated user expectations that occur in each of the phases of the information technology outsourcing life cycle are identified. Following the identification of the management and user expectation issues in each phase of the outsource life cycle, the “Coetzee solution framewo...

Data management issues in mobile ad hoc networks.

Science.gov (United States)

Hara, Takahiro

2017-01-01

Research on mobile ad hoc networks (MANETs) has become a hot research topic since the middle 1990's. Over the first decade, most research focused on networking techniques, ignoring data management issues. We, however, realized early the importance of data management in MANETs, and have been conducting studies in this area for 15 years. In this review, we summarize some key technical issues related to data management in MANETs, and the studies we have done in addressing these issues, which include placement of data replicas, update management, and query processing with security management. The techniques proposed in our studies have been designed with deep considerations of MANET features including network partitioning, node participation/disappearance, limited network bandwidth, and energy efficiency. Our studies published in early 2000's have developed a new research field as data management in MANETs. Also, our recent studies are expected to be significant guidelines of new research directions. We conclude the review by discussing some future directions for research.

'Managing' the immune system with total lymphoid irradiation

International Nuclear Information System (INIS)

Strober, S.

1981-01-01

Total lymphoid irradiation (TLI), which in the past was limited to the treatment of malignant disease, is now emerging as a practical technique in the management of unwanted immune reactions in the areas of transplant tolerance and various autoimmune diseases. Current studies are particularly promising for application of TLI in rheumatoid arthritis and lupus nephritis

Public policy issues in nuclear waste management

International Nuclear Information System (INIS)

Nealey, S.M.; Radford, L.M.

1978-10-01

This document aims to raise issues and to analyze them, not resolve them. The issues were: temporal equity, geographic and socioeconomic equity, implementation of a nuclear waste management system, and public involvement

Immunization Information System and Informatics to Promote Immunizations: Perspective From Minnesota Immunization Information Connection.

Science.gov (United States)

Muscoplat, Miriam Halstead; Rajamani, Sripriya

2017-01-01

The vision for management of immunization information is availability of real-time consolidated data and services for all ages, to clinical, public health, and other stakeholders. This is being executed through Immunization Information Systems (IISs), which are population-based and confidential computerized systems present in most US states and territories. Immunization Information Systems offer many functionalities, such as immunization assessment reports, client follow-up, reminder/recall feature, vaccine management tools, state-supplied vaccine ordering, comprehensive immunization history, clinical decision support/vaccine forecasting and recommendations, data processing, and data exchange. This perspective article will present various informatics tools in an IIS, in the context of the Minnesota Immunization Information Connection.

96 Globalization and Management: Issues and Concepts

African Journals Online (AJOL)

User

2010-10-17

Oct 17, 2010 ... Oseyomon, Ehi Patrick - Department of Business, Admiistration, Faculty of. Management ... attention of scholars apart from economic issues such as trade, labour practices, the ..... Moral Issues in Business. 6th Edition. In C.

Strategic Issues in University Management

NARCIS (Netherlands)

Roosendaal, Hans E.

2005-01-01

In this paper we will discuss developments in the field of scientific information with the aim to determine and analyse some of the pertinent strategic issues related to higher education (HE) as seen from the stakeholder perspective of the university and its management.

Knowledge Management Issues in Academic Libraries in Imo State ...

African Journals Online (AJOL)

This paper explored the Knowledge Management (KM) issues in academic libraries. It discussed these issues - types of knowledge and knowledge management practices; the technologies and mechanisms of acquiring; creating; sharing, transferring etc knowledge in the present day knowledge era. It highlighted the ...

Information Systems Management: an Australian view of the key issues

Directory of Open Access Journals (Sweden)

Graham Pervan

1994-05-01

Full Text Available Studies investigating the key issues in IS management serve to better understand the concerns of IS managers and help to guide IS researchers in choosing IS management problems worthy of investigation. This paper presents results from a study of the key issues facing the IS managers of Australia's largest 300 organisations which is part of a three-yearly longitudinal study. In order to gain consensus on the relative importance of the key issues, a three-round Delphi method was applied. The results reveal that IS strategic planning continues to be the paramount issue in our industry, as are many issues associated with IS strategic planning, including responsiveness of the IT infrastructure, effective use of the data resource, IS for competitive advantage, and a comprehensive information architecture. A greater emphasis on quality is also revealed in highly rated issues such as effective use of the data resource, data integrity and quality assurance, and the quality of software development

Management issues regarding the contingent workforce

Energy Technology Data Exchange (ETDEWEB)

Bowen-Smed, S. [Bowen Workforce Solutions, Calgary, AB (Canada)

2004-07-01

Fifty per cent of corporate leaders in Calgary today will be eligible for retirement over the next 5 years. In addition, 53 per cent of the entire Calgary workforce is 45 years or older. This paper suggests that only companies that seek aggressive programs to engage immigrants and contractors will weather the skills shortages anticipated in the future. It was noted that contractors care about aligning values to organizations, regardless of the project length, and that professional development is a key consideration when it comes to selecting their next project. Contingent workforce issues include: effectiveness; classification; risk; and cost. It was stated that effectiveness of the contingent workforce is an employer's responsibility. Factors that would strengthen the relationship between corporations and contractors include: proper orientation to manage expectations; training to improve productivity; tracking to enhance the quality of the workforce; and a management process to ensure adherence to protocol. It was concluded that the contingent workforce is an essential component to human capital management strategy, but that key issues must be managed to avoid unnecessary costs. In addition, effectiveness improves when processes are implemented. It was also suggested that technology is an essential component of the solution. Outsourcing is an effective approach to managing the contingent workforce. tabs., figs.

Challenges and Issues in Knowledge Management

DEFF Research Database (Denmark)

"Challenges and Issues in Knowledge Management" - the fifth volume in the "Research on Management Consulting" series - presents sixteen chapters that explore these various perspectives, focusing on knowledge management within the context of the management consulting industry, the dynamics...... associated with knowledge sharing and dissemination, methodological approaches to studying knowledge in organizations, and reflections on knowledge management and management consulting. As the chapters underscore, it is important to ensure that KM initiatives are aligned with the needs of the organization...... and its members, that the KM system is "owned" by organizational members with particular emphasis on executive sponsorship and team member acceptance, and that it be understood as an ongoing process rather than simply another management objective or faddish consulting tool. The focus, therefore, should...

Practice management: observations, issues, and empirical evidence.

Science.gov (United States)

Wong, H M; Braithwaite, J

2001-02-01

The primary objective of this study is to provide objective, empirical, evidence-based practice management information. This is a hitherto under-researched area of considerable interest for both the practitioner and educator. A questionnaire eliciting a mix of structured and free text responses was administered to a random sample of 480 practitioners who are members of the American Academy of Periodontology. Potential respondents not in private practice were excluded and the next listed person substituted. The results provide demographic and descriptive information about some of the main issues and problems facing practice managers, central to which are information technology (IT), financial, people management, and marketing. Human resource and marketing management appear to represent the biggest challenges. Periodontists running practices would prefer more information, development, and support in dealing with IT, finance, marketing, and people management. The empirical evidence reported here suggests that although tailored educational programs on key management issues at both undergraduate and postgraduate levels have become ubiquitous, nevertheless some respondents seek further training opportunities. Evidence-based practice management information will be invaluable to the clinician considering strategic and marketing planning, and also for those responsible for the design and conduct of predoctoral and postdoctoral programs.

Managing mixed wastes: technical issues

International Nuclear Information System (INIS)

Lytle, J.E.; Eyman, L.D.; Burton, D.W.; McBrayer, J.F.

1986-01-01

The US Department of Energy manages wastes that are both chemically hazardous and radioactive. These mixed wastes are often unique and many have national security implications. Management practices have evolved over the more than forty years that the Department and its predecessor agencies have been managing these wastes, both in response to better understanding of the hazards involved and in response to external, regulatory influences. The Department has recently standarized its waste management practices and has initited an R and D program to address priority issues identified by its operating contractor organizations. The R and D program is guided by waste management strategy that emphasizes reduction of human exposure to hazardous wastes in the environment, reduction of the amount and toxicity of wastes generated, treatment of wastes that are generated to reduce volumes and toxicities, and identification of alternatives to land disposal of wastes that remain hazardous following maximum practicable treatment

Topics in this issue: cancer testes antigens, immune checkpoints, inflammation associated with ischemia-reperfusion and integrin targeting.

Science.gov (United States)

Bot, Adrian; Chiriva-Internati, Maurizio

2012-10-01

This issue of the International Reviews of Immunology is dedicated to several topics: cancer immunotherapy, and basic and translational aspects of immunity. Two reviews, one focused on breast and the other on lung cancer, highlight the need to redefine the cancer testes antigens (CTAs) as novel information regarding their expression profile and biological role emerges. Two other reviews showcase pivotal molecules that keep in check immunity at two different levels: the transcription factor autoimmune regulator (AIRE) important to negative selection of the T-cell repertoire, and CD22 that limits the antigen-initiated B-cell response. Two other articles focus on the debated role of Toll-like receptors (TLRs) and inflammation in general, in ischemia-reperfusion lesions that follow cardiovascular disorders and stroke. Last but not the least, this issue hosts a review that discusses the role and translational potential of the α4 integrin for the treatment of inflammatory bowel disease (IBD).

Undergoing an immunization is effortlessly, manageable or difficult according to five-year-old children.

Science.gov (United States)

Harder, Maria; Christensson, Kyllike; Söderbäck, Maja

2015-06-01

To prevent diseases among children they regularly undergo immunizations. Previous research show different approaches available to facilitate immunization-procedures for children to protect them from harm. To complement this research and provide care suited for children, research recognizing their perceptions of undergoing such a procedure is needed. The aim of this study was to describe 5-year-old children's perceptions of undergoing an immunization. A phenomenographic approach and analysis was used to describe the children's (n = 21) various perceptions. The data-collection was accomplished directly after the immunization to grasp the children's immediate perceptions. Drawings and reflective talks were used as they are considered as suitable methods when involving young children in research. The right to conduct research with children was approved by the appropriate research ethics committee and also by each child and the parents. The findings show that children's perceptions of an immunization-procedure may vary from effortlessly, to manageable or difficult. Regardless of how the child perceive the immunization-procedure each perception embrace the children's descriptions of actors and articles in the situation, their feelings in the situation and also their actions to deal with the immunization. Nevertheless, these descriptions vary according to how the children perceive the immunization as effortlessly, manageable or difficult. Children's and adults' perceptions of medical procedures may differ and children need guidance, time and space to deal with them. Recognizing children's perceptions of undergoing an immunization contributes to the promotion of their right to be involved in their own health care and towards the development of child-centred care. © 2014 Nordic College of Caring Science.

Nontechnical issues in waste management: ethical, institutional, and political concerns

International Nuclear Information System (INIS)

Hebert, J.A.; Rankin, W.L.; Brown, P.G.; Schuller, C.R; Smith, R.F.; Goodnight, J.A.; Lippek, H.E.

1978-05-01

The report consists of a presentation and distillation of major nontechnical issues surrounding commercial waste management, followed by ethical, institutional, and political analyses of these issues. The ethical analysis consists of a discusson of what is meant by ''ethics'' and ''morality'' in the waste management context and an illustrative attempt at an ethical analysis of the commercial nuclear waste problem. Two institutional analyses are presented: one is an analysis of the possible problems of long-term human institutions in waste management; the other is a presentation of institutional arrangements for the short term. A final chapter discusses issues and concerns involving intergovernmental relations--that is, local, state, and federal interface problems in waste management

Polio Eradication Initiative contribution in strengthening immunization and integrated disease surveillance data management in WHO African region, 2014.

Science.gov (United States)

Poy, Alain; Minkoulou, Etienne; Shaba, Keith; Yahaya, Ali; Gaturuku, Peter; Dadja, Landoh; Okeibunor, Joseph; Mihigo, Richard; Mkanda, Pascal

2016-10-10

The PEI Programme in the WHO African region invested in recruitment of qualified staff in data management, developing data management system and standards operating systems since the revamp of the Polio Eradication Initiative in 1997 to cater for data management support needs in the Region. This support went beyond polio and was expanded to routine immunization and integrated surveillance of priority diseases. But the impact of the polio data management support to other programmes such as routine immunization and disease surveillance has not yet been fully documented. This is what this article seeks to demonstrate. We reviewed how Polio data management area of work evolved progressively along with the expansion of the data management team capacity and the evolution of the data management systems from initiation of the AFP case-based to routine immunization, other case based disease surveillance and Supplementary immunization activities. IDSR has improved the data availability with support from IST Polio funded data managers who were collecting them from countries. The data management system developed by the polio team was used by countries to record information related to not only polio SIAs but also for other interventions. From the time when routine immunization data started to be part of polio data management team responsibility, the number of reports received went from around 4000 the first year (2005) to >30,000 the second year and to >47,000 in 2014. Polio data management has helped to improve the overall VPD, IDSR and routine data management as well as emergency response in the Region. As we approach the polio end game, the African Region would benefit in using the already set infrastructure for other public health initiative in the Region. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

Some Issues on Management Information System Course Teaching

OpenAIRE

Chen, Dingquan

2008-01-01

This paper discuses the following issues about Management Information System course for the major of information management & Information System: Teaching Object, the difference between Information System Analysis and Design course, teaching content, and experiment plan.

Issues related to EM management of DOE spent nuclear fuel

International Nuclear Information System (INIS)

Abbott, D.G.; Abashian, M.S.; Chakraborti, S.; Roberson, K.; Meloin, J.M.

1993-07-01

This document is a summary of the important issues involved in managing spent nuclear fuel (SNF) owned by the Department of Energy (DOE). Issues related to civilian SNF activities are not discussed. DOE-owned SNF is stored primarily at the Hanford Site, Idaho National Engineering Laboratory (INEL), Savannah River Site (SRS), Oak Ridge National Laboratory (ORNL), and West Valley Demonstration Project. Smaller quantities of SNF are stored at Brookhaven National Laboratory, Sandia National Laboratories, and Los Alamos National Laboratory (LANL). There is a wide variety of fuel types, including both low and high enrichment fuels from weapons production, DOE reactors, research and development programs, naval programs, and universities. Most fuel is stored in pools associated with reactor or reprocessing facilities. Smaller quantities are in dry storage. Physical conditions of the fuel range from excellent to poor or severely damaged. An issue is defined as an important question that must be answered or decision that must be made on a topic or subject relevant to achieving the complimentary objectives of (a) storing SNF in compliance with applicable regulations and orders until it can be disposed, and (b) safely disposing of DOE's SNF. The purpose of this document is to define the issues; no recommendations are made on resolutions. As DOE's national SNF management program is implemented, a system of issues identification, documentation, tracking, and resolution will be implemented. This document is an initial effort at issues identification. The first section of this document is an overview of issues that are common to several or all DOE facilities that manage SNF. The common issues are organized according to specific aspects of spent fuel management. This is followed by discussions of management issues that apply specifically to individual DOE facilities. The last section provides literature references

Resensi Buku Islamic Perspective on Management: Contemporary Issues

OpenAIRE

Kusuma, Bayu Mitra Adhyatma

2016-01-01

Judul buku : Islamic Perspective on Management: ContemporaryIssuesPenulis : Nor ‘Azizah Kamri, dkk.Penerbit : YaPEIM Management Academy (kerjasamadengan University of Malaya Press)Tebal : xiv + 463 halamanCetakan pertama : November 2013Kota terbit : Kuala Lumpur

Nontechnical issues in waste management: ethical, institutional, and political concerns

Energy Technology Data Exchange (ETDEWEB)

Hebert, J.A.; Rankin, W.L.; Brown, P.G.; Schuller, C.R; Smith, R.F.; Goodnight, J.A.; Lippek, H.E.

1978-05-01

The report consists of a presentation and distillation of major nontechnical issues surrounding commercial waste management, followed by ethical, institutional, and political analyses of these issues. The ethical analysis consists of a discusson of what is meant by ''ethics'' and ''morality'' in the waste management context and an illustrative attempt at an ethical analysis of the commercial nuclear waste problem. Two institutional analyses are presented: one is an analysis of the possible problems of long-term human institutions in waste management; the other is a presentation of institutional arrangements for the short term. A final chapter discusses issues and concerns involving intergovernmental relations--that is, local, state, and federal interface problems in waste management.

Strategic Issues in University Information Management

Science.gov (United States)

Roosendaal, Hans E.

This chapter represents a specific view on university management. It sequentially discusses different organizational levels of e-teaching, starting with general management, e-science developments and what this means to universities, and business models followed by focusing on specific teaching issues. The chapter sets out to discuss the development of the university from a loose federation of faculties into a more integrated university, such as, e.g., an entrepreneurial university. This development is also driven by the introduction of the bachelors/masters system - a process which leads to the need for an institutional strategy introducing institutional quality management and has to be accompanied by the independent accreditation of research and teaching. Applying the model of strategic positioning to the university as a whole leads to the introduction of the university entrepreneur. The model is used to describe structural issues and the relations between the primary processes of research and teaching with the secondary processes. e-science is introduced as a further step toward the universal sharing of scientific results and to analyze the kind of incentives that will be required to attain this goal of making information an even more integral part of the research and teaching process.

Understanding the policy environment for immunization supply chains: Lessons learned from landscape analyses in Uganda and Senegal.

Science.gov (United States)

Luzze, Henry; Badiane, Ousseynou; Mamadou Ndiaye, El Hadji; Ndiaye, Annette Seck; Atuhaire, Brian; Atuhebwe, Phionah; Guinot, Phillippe; Fry Sosne, Erin; Gueye, Abdoulaye

2017-04-19

As immunization programs around the world undergo rapid change and expansion, supply chain and logistics systems have become strained, making it increasingly challenging for national public health systems to provide reliable, safe, and efficient access to vaccines. Governments and immunization partners have been aware of this problem for several years, and in 2010, the World Health Organization (WHO) launched the Effective Vaccine Management (EVM) process to help countries identify shortcomings in their immunization supply chains and develop plans for systematic improvement. EVM improvement plans now exist in all Gavi-eligible countries plus many middle- and upper-income countries; however, implementation has been slow and in many cases fraught with financial, managerial, structural, and political roadblocks. Recognizing that significant change of any kind requires a supportive policy environment and strong leadership, PATH began working in Uganda and Senegal to landscape the policy environment around immunization and identify relevant policies, administrative and technical roles and responsibilities, and other issues that may be affecting the supply chain for immunization. The policy landscape assessments included a desk review and a series of structured, in-depth interviews with key international, national, and local stakeholders. The findings highlighted a number of critical issues and challenges in both countries that may be preventing supply chains from functioning optimally. These challenges include a need for better coordination and planning between immunization programs and supply chain managers; the need for sufficient, timely and reliable financing for all aspects of immunization programs; the need for high-level managers trained in immunization supply chain management; and an urgent need for better, more timely data for decision-making. Overcoming these challenges will require the involvement of high-level political actors-including ministers of health

PERFECTION OF THE ALGORITHM FOR MANAGING PREGNANT WOMEN WITH RHESUS IMMUNIZATION: DIAGNOSTIC ASPECTS

Directory of Open Access Journals (Sweden)

Елена Николаевна Кравченко

2017-11-01

The conclusion. The determination of TBG in a rhesus-conflict pregnancy tested at gestational age of 35 or more is an additional criterion for the prediction of an unfavorable perinatal outcome in rhesus immunization. An integrated approach to the management of pregnant women with rhesus immunization can reduce the number of preterm infants with hemolytic disease, the number of children in need of supervision and treatment in the intensive care unit

Current Diagnosis and Management of Immune Related Adverse Events (irAEs Induced by Immune Checkpoint Inhibitor Therapy

Directory of Open Access Journals (Sweden)

Vivek Kumar

2017-02-01

Full Text Available The indications of immune checkpoint inhibitors (ICIs are set to rise further with the approval of newer agent like atezolimumab for use in patients with advanced stage urothelial carcinoma. More frequent use of ICIs has improved our understanding of their unique side effects, which are known as immune-related adverse events (irAEs. The spectrum of irAEs has expanded beyond more common manifestations such as dermatological, gastrointestinal and endocrine effects to rarer presentations involving nervous, hematopoietic and urinary systems. There are new safety data accumulating on ICIs in patients with previously diagnosed autoimmune conditions. It is challenging for clinicians to continuously update their working knowledge to diagnose and manage these events successfully. If diagnosed timely, the majority of events are completely reversible, and temporary immunosuppression with glucocorticoids, infliximab or other agents is warranted only in the most severe grade illnesses. The same principles of management will possibly apply as newer anti- cytotoxic T lymphocytes-associated antigen 4 (CTLA-4 and programmed cell death protein 1 (PD-1/PD-L1 antibodies are introduced. The current focus of research is for prophylaxis and for biomarkers to predict the onset of these toxicities. In this review we summarize the irAEs of ICIs and emphasize their growing spectrum and their management algorithms, to update oncology practitioners.

A CEO View of Key Issues in Australian Information Systems Management - 1997

Directory of Open Access Journals (Sweden)

Graham Pervan

1998-05-01

Full Text Available As part of a research programme on key information systems management issues, a survey of Australasia's largest 500 organisations was conducted to identify which issues were perceived by their chief executive officers (CEOs as being important, problematic and critical over the next three to five years. The results reported are based on a relatively low response rate (though perhaps reasonable for the target group so should be regarded as only exploratory. The most critical issues were revealed to be a mix of technology management issues (IT infrastructure, disaster recovery, strategic management issues (BPR, competitive advantage, information architecture, people management issues (organisational learning, systems development and data management issues (effective use of the data resource, effectiveness/productivity of IS, effectiveness of software development, and their own support systems (EIS/DSS. This reflects their interest in a wide range of issues, but all with an organisation-wide focus. Non-critical issues were mostly related to the individual technologies and the place and role of IS in the organisation. While the CEOs showed some agreement with their chief information officers (CIOs on issues such as the IT infrastructure, competitive advantage, and organisational learning some distinct differences exist, particularly in relation to the quality and effectiveness of systems and processes and also how CEOs and CIOs perceive each other.

Too many crying babies: a systematic review of pain management practices during immunizations on YouTube

Science.gov (United States)

2014-01-01

Background Early childhood immunizations, although vital for preventative health, are painful and too often lead to fear of needles. Effective pain management strategies during infant immunizations include breastfeeding, sweet solutions, and upright front-to-front holding. However, it is unknown how often these strategies are used in clinical practice. We aimed to review the content of YouTube videos showing infants being immunized to ascertain parents’ and health care professionals’ use of pain management strategies, as well as to assess infants’ pain and distress. Methods A systematic review of YouTube videos showing intramuscular injections in infants less than 12 months was completed using the search terms "baby injection" and "baby vaccine" to assess (1) the use of pain management strategies and (2) infant pain and distress. Pain was assessed by crying duration and pain scores using the FLACC (Face, Legs, Activity, Cry, Consolability) tool. Results A total of 142 videos were included and coded by two trained individual viewers. Most infants received one injection (range of one to six). Almost all (94%) infants cried before or during the injections for a median of 33 seconds (IQR = 39), up to 146 seconds. FLACC scores during the immunizations were high, with a median of 10 (IQR = 3). No videos showed breastfeeding or the use of sucrose/sweet solutions during the injection(s), and only four (3%) videos showed the infants being held in a front-to-front position during the injections. Distraction using talking or singing was the most commonly used (66%) pain management strategy. Conclusions YouTube videos of infants being immunized showed that infants were highly distressed during the procedures. There was no use of breastfeeding or sweet solutions and limited use of upright or front-to-front holding during the injections. This systematic review will be used as a baseline to evaluate the impact of future knowledge translation interventions using

Too many crying babies: a systematic review of pain management practices during immunizations on YouTube.

Science.gov (United States)

Harrison, Denise; Sampson, Margaret; Reszel, Jessica; Abdulla, Koowsar; Barrowman, Nick; Cumber, Jordi; Fuller, Ann; Li, Claudia; Nicholls, Stuart; Pound, Catherine M

2014-05-29

Early childhood immunizations, although vital for preventative health, are painful and too often lead to fear of needles. Effective pain management strategies during infant immunizations include breastfeeding, sweet solutions, and upright front-to-front holding. However, it is unknown how often these strategies are used in clinical practice. We aimed to review the content of YouTube videos showing infants being immunized to ascertain parents' and health care professionals' use of pain management strategies, as well as to assess infants' pain and distress. A systematic review of YouTube videos showing intramuscular injections in infants less than 12 months was completed using the search terms "baby injection" and "baby vaccine" to assess (1) the use of pain management strategies and (2) infant pain and distress. Pain was assessed by crying duration and pain scores using the FLACC (Face, Legs, Activity, Cry, Consolability) tool. A total of 142 videos were included and coded by two trained individual viewers. Most infants received one injection (range of one to six). Almost all (94%) infants cried before or during the injections for a median of 33 seconds (IQR = 39), up to 146 seconds. FLACC scores during the immunizations were high, with a median of 10 (IQR = 3). No videos showed breastfeeding or the use of sucrose/sweet solutions during the injection(s), and only four (3%) videos showed the infants being held in a front-to-front position during the injections. Distraction using talking or singing was the most commonly used (66%) pain management strategy. YouTube videos of infants being immunized showed that infants were highly distressed during the procedures. There was no use of breastfeeding or sweet solutions and limited use of upright or front-to-front holding during the injections. This systematic review will be used as a baseline to evaluate the impact of future knowledge translation interventions using YouTube to improve pain management practices for infant

Key management issue in SCADA networks: A review

Directory of Open Access Journals (Sweden)

Abdalhossein Rezai

2017-02-01

Full Text Available Supervisory Control And Data Acquisition (SCADA networks have a vital role in Critical Infrastructures (CIs such as public transports, power generation systems, gas, water and oil industries, so that there are concerns on security issues in these networks. The utilized Remote Terminal Units (RTUs and Intelligence Electronic Devices (IEDs in these networks have resource limitations, which make security applications a challenging issue. Efficient key management schemes are required besides lightweight ciphers for securing the SCADA communications. Many key management schemes have been developed to address the tradeoff between SCADA constrain and security, but which scheme is the most effective is still debatable. This paper presents a review of the existing key management schemes in SCADA networks, which provides directions for further researches in this field.

Critical issues facing R&D managers in China

NARCIS (Netherlands)

de Boer, S.J.; Gan, Weibing; Shan, Guogang

1998-01-01

R&D managers in China experienced significant changes in the past decade, in particular because of Government policies of economic reform and opening to the outside world. These developments have brought about a number of rather specific R&D management issues and problems. The paper addresses the

Intelligence Community Programs, Management, and Enduring Issues

Science.gov (United States)

2016-11-08

books, journal papers, conference presentations, working papers, and other electronic and print publications. Intelligence Community Programs... Intelligence Community Programs, Management, and Enduring Issues Anne Daugherty Miles Analyst in Intelligence and National Security Policy...

International consensus report on the investigation and management of primary immune thrombocytopenia

NARCIS (Netherlands)

Provan, Drew; Stasi, Roberto; Newland, Adrian C.; Blanchette, Victor S.; Bolton-Maggs, Paula; Bussel, James B.; Chong, Beng H.; Cines, Douglas B.; Gernsheimer, Terry B.; Godeau, Bertrand; Grainger, John; Greer, Ian; Hunt, Beverley J.; Imbach, Paul A.; Lyons, Gordon; McMillan, Robert; Rodeghiero, Francesco; Sanz, Miguel A.; Tarantino, Michael; Watson, Shirley; Young, Joan; Kuter, David J.

2010-01-01

Previously published guidelines for the diagnosis and management of primary immune thrombocytopenia (ITP) require updating largely due to the introduction of new classes of therapeutic agents, and a greater understanding of the disease pathophysiology. However, treatment-related decisions still

Getting Stakeholder Issues into the Management of Radioactive Waste

International Nuclear Information System (INIS)

Atherton, Elizabeth

2001-01-01

The issues raised in trying to develop long-term solution(s) for radioactive waste management are multidisciplinary - encompassing social, ethical, scientific and technical issues. Experience in the UK and elsewhere has shown that the process by which decisions are made needs to be accepted as being legitimate by all stakeholders. This paper argues that the key to achieving such acceptance is how one engages with stakeholders at the 'front-end' of any decision-making process. This paper focuses on radioactive waste management as the issue in question and outlines techniques that can be used during the 'front-end' consultation and gives examples of where they have been, and are being, used by Nirex

Getting Stakeholder Issues into the Management of Radioactive Waste

Energy Technology Data Exchange (ETDEWEB)

Atherton, Elizabeth [UK Nirex Ltd, Didcot (United Kingdom)

2001-07-01

The issues raised in trying to develop long-term solution(s) for radioactive waste management are multidisciplinary - encompassing social, ethical, scientific and technical issues. Experience in the UK and elsewhere has shown that the process by which decisions are made needs to be accepted as being legitimate by all stakeholders. This paper argues that the key to achieving such acceptance is how one engages with stakeholders at the 'front-end' of any decision-making process. This paper focuses on radioactive waste management as the issue in question and outlines techniques that can be used during the 'front-end' consultation and gives examples of where they have been, and are being, used by Nirex.

Effective time management – selected issues

Directory of Open Access Journals (Sweden)

Aneta Olejniczak

2013-03-01

Full Text Available Deliberations included in this article contain the basic issues related to the subject of time management. As we know, people who waste their time the most, most complain about the lack of the time. We should treat our time, time of our co-workers, and friends as a valuable, but limited wealth. Principles of effective time management can be applied in any scientific and research institutions, companies or corporations. The benefits of a good and effective time management will be felt not only by ourselves but also by our friends and family. Detailed formulation of objectives, identification and elimination of time wasters and postponing work on later (Procrastination, using methods of time management and systematic control will allow for efficient use of time. A good plan is the basis for optimal and meaningful use of time.

Issues Raised in Relation to Radioactive Waste Management

International Nuclear Information System (INIS)

Atherton, Elizabeth

2003-01-01

Nirex has undertaken various consultations with different stakeholders to identify their issues and concerns about radioactive waste management in general and specific aspects of Nirex's work. This paper will outline what dialogue techniques Nirex has undertaken and the issues and concerns that people have raised during the events. It will outline some of the work that Nirex is undertaking to address stakeholders' issues and concerns. Nirex has used a variety of dialogue techniques co-ordinated under the Nirex Involvement Programme to engage with stakeholders about the work we undertake. We are now trying to address the issues, concerns, scenarios and questions raised in our work programme. Key lessons that we have learned in undertaking the dialogues include: The importance of appropriate facilitation and organisation of meetings; The need for a clear purpose for meetings; Being flexible to the needs of the attendees and the issues they raise; Providing feedback to those who participate and following up issues. Through engaging with the public Nirex has learned that: Radioactive waste is not an everyday concern for people; The public can, will and want to engage with the issue of radioactive waste management. This includes engaging with the ethical debate. To facilitate this Nirex and others need to: Provide information in a neutral form outlining the pros and cons and including various people's opinions; Use proactive techniques to allow access and space for people to discuss the issues; Demonstrate how people's opinions have been taken into account. People understand the issues very differently to the way institutions understand them. There is a need for institutions to learn to understand public concerns and the ways in which the public understand issues, as well as for the public to understand the institutional positions better. We are using these insights to develop our future work in this area

Herpes Zoster Immunization in Older Adults Has Big Benefits.

Science.gov (United States)

Breivik, Harald

2015-09-01

A case of acute herpes zoster neuralgia (shingles) in a 78-year-old patient is described. The value and importance of immunizing against herpes zoster to decrease the incidence and severity of both acute herpes zoster neuralgia and postherpetic neuralgia are described. --This report is adapted from paineurope 2015: Issue 1, ©Haymarket Medical Publications Ltd., and is presented with permission. paineurope is provided as a service to pain management by Mundipharma International, Ltd., and is distributed free of charge to health care professionals in Europe. Archival issues can be viewed via the Web site: www.paineurope.com , at which health professionals can find links to the original articles and request copies of the quarterly publication and access additional pain education and pain management resources.

The Immune System and Bodily Defence

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 2; Issue 2. The Immune System and Bodily Defence How Do Parasites and the Immune System Choose their Dances? Vineeta Bal Satyajit Rath. Series Article Volume 2 Issue 2 February 1997 pp 17-24 ...

The Immune System and Bodily Defence

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 2; Issue 9. The Immune System and Bodily Defence How Does the Immune System Recognize Everything Under the Sun? Vineeta Bal Satyajit Rath. Series Article Volume 2 Issue 9 September 1997 pp 6-10 ...

An Investigation of Information Technology-Enabled Remote Management and Remote Work Issues

Directory of Open Access Journals (Sweden)

D. Sandy Staples

1997-05-01

Full Text Available A two phase research study was done to investigate remote work and remote management issues. In Phase 1, focus groups were carried out with remote managers and remote employees to identify key issues. The most common key issues dealt with communications, information technology, leadership and coaching, teamwork, building trust, and performance management. In the second phase, a questionnaire was used to test hypotheses developed from phase 1. The findings supported that higher trust leads to higher job satisfaction and lower job stress, and that more communication between the manager and the remote employee develops higher levels of employee organizational commitment.

Decommissioning and material recycling. Radiation risk management issues

International Nuclear Information System (INIS)

Dodd, D.H.

1996-09-01

Once nuclear fuel cycle facilities have permanently stopped operations they have to be decommissioned. The decommissioning of a nuclear facility involves the surveillance and dismantling of the facility systems and buildings, the management of the materials resulting from the dismantling activities and the release of the site for further use. The management of radiation risks associated with these activities plays an important role in the decommissioning process. Existing legislation covers many aspects of the decommissioning process. However, in most countries with nuclear power programmes legislation with respect to decommissioning is incomplete. In particular this is true in the Netherlands, where government policy with respect to decommissioning is still in development. Therefore a study was performed to obtain an overview of the radiation risk management issues associated with decommissioning and the status of the relevant legislation. This report describes the results of that study. It is concluded that future work at the Netherlands Energy Research Foundation on decommissioning and radiation risk management issues should concentrate on surveillance and dismantling activities and on criteria for site release. (orig.)

Potential Interface Issues in Spent Fuel Management

International Nuclear Information System (INIS)

2015-10-01

This publication is an output of a series of meetings to identify and evaluate issues and opportunities associated with interfaces in the back end of the fuel cycle (BEFC) and to describe effective management approaches based on the experience of Member States. During the meetings, participants from Member States and other international organizations shared and evaluated the main interfaces and potential interface issues among the spent fuel storage, transport, reprocessing and disposal of the BEFC, and also reviewed the national approaches to addressing these issues. The aim of this publication is to provide an approach to identify the interfaces in the BEFC as well as the potential issues that should be addressed. It also aims at responding to the solutions Member States most often find to be effective and, in some cases, were adjusted or revisited to reach the fixed target. Most of the interfaces and issues are country specific, as evidenced by the variety and diversity of examples provided in this publication

Closing unprofitable services: ethical issues and management responses.

Science.gov (United States)

Summers, James W

1985-01-01

Closing unprofitable services often requires as much analysis, public relations, marketing, and planning as any expansion. Further, issues about ethics, indigents, and the hospital mission force the consideration of values explicitly if a marketing fiasco is to be avoided. By integrating values analysis with more traditional management tasks, the challenges of service closure can be converted into opportunities to demonstrate how your institution has met or exceeded its ethical obligations. A case involving OB is developed to show how ethical and management issues blend into one another. Specific strategies for consensus building and marketing of the legitimacy of the hospital's position are given. Institutional ethics committees are one primary mechanism for developing a plan to benefit from unpleasant decisions.

Issues on management, stabilization and environmental impacts of uranium mill tailings

International Nuclear Information System (INIS)

Cunningham, R.E.

1978-01-01

Management and stabilization of uranium mill tailings has been controversial for over two decades. There are two basic issues: the nature of the risk to the public from tailings and what must be done to mitigate that risk. This paper provides an overview of the issues and sets some goals to be accomplished at the 1978 NEA Seminar on Management, Stabilization and Environmental Impacts of Uranium Mill Tailings that could be helpful in resolving the issues

Treatment of severe non-infectious uveitis in high-risk conditions (Part I): pregnancy and malignancies, management and safety issues.

Science.gov (United States)

Cordero-Coma, Miguel; Salazar-Méndez, Raquel; Yilmaz, Taygan

2015-07-01

Management of patients with severe immune-mediated uveitis requires the use of immunosuppressive drugs in selected cases. This may be especially challenging in certain patients with concomitant conditions, which could increase the risk of side effects or modify guidelines for the use of such drugs. Therapeutic decision-making and management may be of particular difficulty in pregnancy as well as in patients with associated malignancies unrelated to a specific ophthalmic inflammatory condition. The main aim of this review is to provide an updated comprehensive practical guide for practitioners regarding the therapeutic decision-making and management of patients with severe immune-mediated uveitis in the context of pregnancy and malignancies. Management of patients with immune-mediated uveitis requiring immunosuppressive/immunomodulatory drugs might be particularly complicated by other conditions affecting their health and immune status. Clinicians should take into account such conditions, which might influence treatment response and the clinical outcome of these patients.

Post-immunization leucocytosis and its implications for the management of febrile infants.

Science.gov (United States)

Prentice, Sarah; Kamushaaga, Zephyrian; Nash, Stephen B; Elliott, Alison M; Dockrell, Hazel M; Cose, Stephen

2018-05-11

Clinical guidelines for management of infants with fever but no evident focus of infection recommend that those aged 1-3 months with a white cell count >15 × 10 9 /l have a full septic screen and be admitted for parenteral antibiotics. However, there is limited information about leucocyte changes following routine immunization, a common cause of fever. We investigated white cell counts shortly after routine immunization in Ugandan infants under 3 months of age. White cell counts were measured in 212 healthy infants following routine immunizations (DTwP-HepB-Hib, oral polio and pneumococcal conjugate 7 vaccines) received prior to 3 months of age. Mean leucocyte counts increased from 9.03 × 10 9 /l (95% confidence interval 8.59-9.47 × 10 9 /l) pre-immunizations to 16.46 × 10 9 /l (15.4-17.52 × 10 9 /l) at one-day post-immunizations at 6 weeks of age, and 15.21 × 10 9 /l (14.07-16.36 × 10 9 /l) at one-day post-immunizations at 10 weeks of age. The leucocytosis was primarily a neutrophilia, with neutrophil percentages one-day post-immunization of 49% at 6 weeks of age and 46% at 10 weeks of age. White cell parameters returned to baseline by two-days post-immunization. No participant received antibiotics when presenting with isolated fever post-immunization and all remained well at follow-up. In our study almost half the children immunization met commonly used criteria for full septic screen and admission for parenteral antibiotics, despite having no serious bacterial infection. These findings add to the growing body of literature that questions the utility of white blood cell measurement in identification of young infants at risk of serious bacterial infections, particularly in the context of recent immunizations, and suggest that further exploration of the effect of different immunization regimes on white cell counts is needed. This observational work was nested within a clinical trial, registration number ISRCTN

Cancer as an immune-mediated disease

Directory of Open Access Journals (Sweden)

Shurin MR

2012-06-01

Full Text Available Michael R ShurinDepartments of Pathology and Immunology, University of Pittsburgh Medical Center, Pittsburgh, PA, USAAbstract: The link between oncology and immunology has a long history and its development is forced by the necessity to develop innovative and highly efficient modalities for immunological destruction of malignant cells. The limited efficacy of surgery, chemotherapy and radiation also exemplify these issues, as these treatments do not eliminate all cancerous cells, do not address the immunosuppressive nature of the disease and can further impair the patient's immune response weakening patient's resistance to the cancer. Multidisciplinary analysis of the interaction between the immune system and cancer in preclinical and clinical settings suggests that the immune system is closely intertwined with both cancer pathogenesis and treatment. On the one hand, cancer is a manifestation of malfunctions in immunity, as malignant cells manage to escape recognition and elimination by the immune system. Chronic infections and inflammation associated with limited or polarized immune responses also contribute to carcinogenesis and tumor progression. The tumor immunoenvironment represents specific conditions and elements that support cancerous cell survival, proliferation and spreading. On the other hand, the specificity and strength of antitumor immunity is a powerful and efficient tool that can be used to recognize and destroy neoplastic cells or their supporting microenvironment. Understanding the role of the immune system in controlling and supporting tumor initiation, formation, growth and progression has crucial implications for cancer therapy and will therefore guide the future development of cancer immunotherapy and its combination with conventional therapies to achieve optimal antitumor effects in patients with different types of cancer.Keywords: tumor immunology and immunotherapy, tumor immunoenvironment, cancer, immunosuppression

Regulatory issues for nuclear power plant life management

International Nuclear Information System (INIS)

Roe, J.

2000-01-01

The workshop of 26-27 june 2000, on nuclear power Plant LIfe Management (PLIM), also included working groups in which major issues facing PLIM activities for nuclear power plants were identified and discussed. The second group was on Regulation. The Regulatory Working Group will attempt to identify some of the more pertinent issues affecting nuclear plant regulation in a changing PLIM environment, to identify some possible actions to be taken to address these issues, and to identify some of the parties responsible for taking these actions. Some preliminary regulatory issues are noted below. This is not intended to be a comprehensive list of such issues but rather is intended to stimulate discussion among the experts attending this Workshop. One of the concerns in the regulatory arena is how the structural integrity of the plants can be assured for an extended lifetime. Technological advances directed toward the following are likely to be important factors in the regulatory process of life extension. - Preventive and corrective maintenance (e.g., water chemistry control, pressure vessel annealing, and replacement of core internals). - Ageing and degradation mechanisms and evaluation (e.g., embrittlement, wear, corrosion/erosion, fatigue, and stress corrosion). - Monitoring, surveillance, and inspection (e.g., fatigue monitoring and non-destructive testing). - Optimisation of maintenance (e.g., using risk-based analysis). On the business side, there is concern about technical support by manufacturers, fuel companies, and construction companies. Maintaining a strong technical base and skilled workers in a potentially declining environment is another concern in the regulatory community. Waste management and decommissioning remain significant issue regarding PLIM. These issues affect all three areas of concern - technology, business, and regulation. It is against this background, that the issues put forth in this paper are presented. The objective of presenting these

The Immune System and Bodily Defence

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 2; Issue 6. The Immune System and Bodily Defence How Does the Immune System Organize Itself so as to Connect Target Recognition to Expected Functions? Vineeta Bal Satyajit Rath. Series Article Volume 2 Issue 6 June 1997 pp 25-38 ...

Inventory management systems : Control and information issues

NARCIS (Netherlands)

Janssen, F.B.S.L.P.

1998-01-01

This dissertation addresses the management of inventory systems. The thesis starts with an exposition on mathematical models that can be used in inventory theory. Then we deal with some information issues related to the demand process. Namely, how to control products that have intermittent demand.

Managing nuclear wastes: an overview of the issues

International Nuclear Information System (INIS)

Cummings, R.G.; Utton, A.E.

1981-01-01

The issues involving nuclear waste management are reviewed. The author points out the need for a critical overview of research priorities concerning nuclear waste management (NWM), and he discusses the uncertainties surrounding the scope of the problem (i.e., the controversy concerning the extent of dangers to public health and safety associated with the transport and storage of nuclear wastes). This article, intended as a introdution to the other nuclear waste management papers in the journal, also briefly discusses the papers

Equity issues in radioactive waste management

International Nuclear Information System (INIS)

Kasperson, R.E.

1984-01-01

The 15 papers in this book deal with the equity issues of locus, legacy and labor/laity as they occur in the nuclear industry's handling of radioactive wastes. The intent is to identify and clarify inequities in alternative approaches to radioactive waste management in a way that will inform current public policy deliberations and planning. The papers are arranged in five parts which put the problem in perspective, then define the locus, the legacy, and the labor problem, and conclude with a set of proposals for a more equitable management. A separate abstract was prepared for each of the 15 chapters selected for INS, EDB, and EPA

Issues for the long term management of radioactive waste

International Nuclear Information System (INIS)

Schneider, T.; Schieber, C.; Lavelle, S.

2006-01-01

High-level radioactive waste are currently managed in interim storage installations, providing an adequate protection of the public and the workers for the short term period. However, the long-term persistence of the radioactivity of the waste gives a new timescale dimension, never experimented by the society for the development of protection systems. In the framework of the European Commission research project 'COWAM-2' (COmmunity WAste Management) dedicated to the governance of radioactive waste management, the issues of 'long term governance' have been addressed by exploring the elements which can contribute to a better integration of the technical and societal time dimensions, taking into account technical, ethical, economic and organizational considerations. The originality of this project is to address the various issues within working groups involving stakeholders from different origins and European countries together with a research team. After a discussion on the time dimensions to be taken into account from the technical and societal perspective, this paper presents, mainly based on the findings of the COWAM-2 project, a brief analysis of the ethical criteria to be considered when future generations are concerned as well as some performance criteria regarding long term governance. Finally, it proposes a discussion on the interest for the radiation protection experts to engage a process with stakeholders concerned by radioactive waste management in order to favour the emergence of a sustainable management responding to the issues at stake and including radiation protection considerations for long term periods. (authors)

Inaugural conference of the International Association of Immunization Managers (IAIM), Istanbul Turkey, 3-4 March 2015.

Science.gov (United States)

Carrasco, Peter; Franco-Paredes, Carlos; Andrus, Jon; Waller, Katie; Maassen, Alison; Symenouh, Emi; Hafalia, Gabrielle

2015-08-07

For more than 35 years, most national immunization programs have established managerial structures and processes for delivering vaccination services to their populations. These days, immunization managers are facing an increasing number of challenges due to the introduction of new vaccines, shifting demographic patterns, complex networks of service providers, and maintaining the gains achieved with previous vaccination efforts. To confront these challenges, better program performance will require better managerial practices, which incorporates new technologies. To that end, the International Association of Immunization Managers (IAIM) is the first global professional association launched to promote superior leadership and management skills among health professionals involved with vaccination efforts worldwide. From 3 to 4 March 2015, approximately 132 members from 70 countries representing six regions, gathered in Istanbul, Turkey for the inaugural conference of IAIM. In the two-day program, members selected thirteen peers to constitute the Governing Council. The 12 articles of the bylaws of the Association were also ratified. This conference was a forum for sharing managerial best practices through networking sessions, breakout sessions, and presentations. Members also learned about IAIM sponsored training opportunities to deepen their managerial competencies through peer-to-peer exchanges and scholarship training programs. We believe that the IAIM inaugural conference was an appropriate platform for equipping managers with tools and professional network of peers to support them in achieving national, regional and global immunization goals, including those of the Global Vaccine Action Plan of the World Health Organization. Copyright © 2015. Published by Elsevier Ltd.. All rights reserved.

Scaling issues in sustainable river basin management

Science.gov (United States)

Timmerman, Jos; Froebich, Jochen

2014-05-01

Sustainable river basin management implies considering the whole river basin when managing the water resources. Management measures target at dividing the water over different uses (nature, agriculture, industry, households) thereby avoiding calamities like having too much, too little or bad quality water. Water management measures are taken at the local level, usually considering the sub-national and sometimes national effects of such measures. A large part of the world's freshwater resources, however, is contained in river basins and groundwater systems that are shared by two or more countries. Sustainable river basin management consequently has to encompass local, regional, national and international scales. This requires coordination over and cooperation between these levels that is currently compressed into the term 'water governance' . Governance takes into account that a large number of stakeholders in different regimes (the principles, rules and procedures that steer management) contribute to policy and management of a resource. Governance includes the increasing importance of basically non-hierarchical modes of governing, where non-state actors (formal organizations like NGOs, private companies, consumer associations, etc.) participate in the formulation and implementation of public policy. Land use determines the run-off generation and use of irrigation water. Land use is increasingly determined by private sector initiatives at local scale. This is a complicating factor in the governance issue, as in comparison to former developments of large scale irrigation systems, planning institutions at state level have then less insight on actual water consumption. The water management regime of a basin consequently has to account for the different scales of water management and within these different scales with both state and non-state actors. The central elements of regimes include the policy setting (the policies and water management strategies), legal setting

Extraction of human factors issues caused by application of the advanced HSI technology and development of human factor issue management system

Energy Technology Data Exchange (ETDEWEB)

Suh, Sang Moon; Lee, Jung Woon; Park, Jae Chang; Oh, In Seok [Korea Atomic Energy Research Institute, Taejon (Korea)

1999-01-01

A comprehensive literature survey was performed in this study to collect human performance issues related to the advanced HSI design features. The literature from not only nuclear industry but also other industries was collected and reviewed. The issues were categorized into the following advanced HSI design features: devices characteristics, levels of automation, information design and management, display management, computerized controls, alarm systems, computerized procedures, staffing and crew coordination, and operator support systems. The classified issues were described with the description framework. Then, the relationship of issues to HSI design process such as human factors analyses, human factors design, and human factors verification and validation was investigated. Finally, the issue management system of server-client environment was developed using Microsoft's Active Server Page technology and Access 97. (author). 18 refs., 6 figs.

Book Review: Current Issues in International Human Resource Management and Strategy Research

DEFF Research Database (Denmark)

Gretzinger, Susanne

2009-01-01

The article reviews the book "Current Issues in International Human Resource Management and Strategy Research," edited by Marion Festing and Susanne Royer.......The article reviews the book "Current Issues in International Human Resource Management and Strategy Research," edited by Marion Festing and Susanne Royer....

Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline.

Science.gov (United States)

Brahmer, Julie R; Lacchetti, Christina; Schneider, Bryan J; Atkins, Michael B; Brassil, Kelly J; Caterino, Jeffrey M; Chau, Ian; Ernstoff, Marc S; Gardner, Jennifer M; Ginex, Pamela; Hallmeyer, Sigrun; Holter Chakrabarty, Jennifer; Leighl, Natasha B; Mammen, Jennifer S; McDermott, David F; Naing, Aung; Nastoupil, Loretta J; Phillips, Tanyanika; Porter, Laura D; Puzanov, Igor; Reichner, Cristina A; Santomasso, Bianca D; Seigel, Carole; Spira, Alexander; Suarez-Almazor, Maria E; Wang, Yinghong; Weber, Jeffrey S; Wolchok, Jedd D; Thompson, John A

2018-02-14

Purpose To increase awareness, outline strategies, and offer guidance on the recommended management of immune-related adverse events in patients treated with immune checkpoint inhibitor (ICPi) therapy. Methods A multidisciplinary, multi-organizational panel of experts in medical oncology, dermatology, gastroenterology, rheumatology, pulmonology, endocrinology, urology, neurology, hematology, emergency medicine, nursing, trialist, and advocacy was convened to develop the clinical practice guideline. Guideline development involved a systematic review of the literature and an informal consensus process. The systematic review focused on guidelines, systematic reviews and meta-analyses, randomized controlled trials, and case series published from 2000 through 2017. Results The systematic review identified 204 eligible publications. Much of the evidence consisted of systematic reviews of observational data, consensus guidelines, case series, and case reports. Due to the paucity of high-quality evidence on management of immune-related adverse events, recommendations are based on expert consensus. Recommendations Recommendations for specific organ system-based toxicity diagnosis and management are presented. While management varies according to organ system affected, in general, ICPi therapy should be continued with close monitoring for grade 1 toxicities, with the exception of some neurologic, hematologic, and cardiac toxicities. ICPi therapy may be suspended for most grade 2 toxicities, with consideration of resuming when symptoms revert to grade 1 or less. Corticosteroids may be administered. Grade 3 toxicities generally warrant suspension of ICPis and the initiation of high-dose corticosteroids (prednisone 1 to 2 mg/kg/d or methylprednisolone 1 to 2 mg/kg/d). Corticosteroids should be tapered over the course of at least 4 to 6 weeks. Some refractory cases may require infliximab or other immunosuppressive therapy. In general, permanent discontinuation of ICPis is

Barriers to Immunizations and Strategies to Enhance Immunization Rates in Adults with Autoimmune Inflammatory Diseases.

Science.gov (United States)

Kirchner, Elizabeth; Ruffing, Victoria

2017-02-01

For as long as there have been immunizations, there have been barriers to them. Immunization rates in the United States are below target. Rheumatologists and rheumatology practitioners need to understand the issues of immunizations in patients with autoimmune inflammatory disease to identify and overcome barriers to immunization. Several strategies for overcoming these barriers are discussed. Copyright © 2016 Elsevier Inc. All rights reserved.

Polio Endgame: Lessons Learned From the Immunization Systems Management Group.

Science.gov (United States)

Zipursky, Simona; Vandelaer, Jos; Brooks, Alan; Dietz, Vance; Kachra, Tasleem; Farrell, Margaret; Ottosen, Ann; Sever, John L; Zaffran, Michel J

2017-07-01

The Immunization Systems Management Group (IMG) was established to coordinate and oversee objective 2 of the Polio Eradication and Endgame Strategic Plan 2013-2018, namely, (1) introduction of ≥1 dose of inactivated poliovirus vaccine in all 126 countries using oral poliovirus vaccine (OPV) only as of 2012, (2) full withdrawal of OPV, starting with the withdrawal of its type 2 component, and (3) using polio assets to strengthen immunization systems in 10 priority countries. The IMG's inclusive, transparent, and partnership-focused approach proved an effective means of leveraging the comparative and complementary strengths of each IMG member agency. This article outlines 10 key factors behind the IMG's success, providing a potential set of guiding principles for the establishment and implementation of other interagency collaborations and initiatives beyond the polio sphere. © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America.

Management issues for high performance storage systems

Energy Technology Data Exchange (ETDEWEB)

Louis, S. [Lawrence Livermore National Lab., CA (United States); Burris, R. [Oak Ridge National Lab., TN (United States)

1995-03-01

Managing distributed high-performance storage systems is complex and, although sharing common ground with traditional network and systems management, presents unique storage-related issues. Integration technologies and frameworks exist to help manage distributed network and system environments. Industry-driven consortia provide open forums where vendors and users cooperate to leverage solutions. But these new approaches to open management fall short addressing the needs of scalable, distributed storage. We discuss the motivation and requirements for storage system management (SSM) capabilities and describe how SSM manages distributed servers and storage resource objects in the High Performance Storage System (HPSS), a new storage facility for data-intensive applications and large-scale computing. Modem storage systems, such as HPSS, require many SSM capabilities, including server and resource configuration control, performance monitoring, quality of service, flexible policies, file migration, file repacking, accounting, and quotas. We present results of initial HPSS SSM development including design decisions and implementation trade-offs. We conclude with plans for follow-on work and provide storage-related recommendations for vendors and standards groups seeking enterprise-wide management solutions.

Long-term issues associated with spent nuclear power fuel management options

International Nuclear Information System (INIS)

Jae-Sol, Lee; Kosaku, Fukuda; Burcl, R.; Bell, M.

2003-01-01

Spent fuel management is perceived as one of the crucial issues to be resolved for sustainable utilisation of nuclear power. In the last decades, spent fuel management policies have shown diverging tendencies among the nuclear power production countries - a group has adhered to reprocessing- recycle and another has turned to direct disposal, while the rest of the countries have not taken decision yet, often with ''wait and see'' position. Both the closed and open fuel cycle options for spent fuel management have been subject to a number of debates with pros and cons on various issues such as proliferation risk, environmental impact, etc. The anticipation for better technical solutions that would mitigate those issues has given rise to the renewal of interest in partitioning and transmutation of harmful nuclides to be disposed of, and in a broader context, the recent initiatives for development of innovative nuclear systems. The current trend toward globalization of market economy, which has already brought important impacts on nuclear industry, might have a stimulating effect on regional-international co-operations for cost-effective efforts to mitigate some of those long-term issues associated with spent fuel management. (author)

An integrative framework for managing project issues across stakeholder groups

NARCIS (Netherlands)

van Offenbeek, Marjolein A.G.; Vos, Janita F.J.

2016-01-01

The stakeholders and the issues associated with a project are different concepts but closely interconnected. Despite this, the project stakeholder management literature falls short in analyzing the linkages between the stakeholders and the issues they bring. This paper develops a multilayered

International trade and waste and fuel managment issue, 2006

Energy Technology Data Exchange (ETDEWEB)

Agnihotri, Newal (ed.)

2006-01-15

The focus of the January-February issue is on international trade and waste and fuel managment. Major articles/reports in this issue include: HLW management in France, by Michel Debes, EDF, France; Breakthroughs from future reactors, by Jacques Bouchard, CEA, France; 'MOX for peace' a reality, by Jean-Pierre Bariteau, AREVA Group, France; Swedish spent fuel and radwaste, by Per H. Grahn and Marie Skogsberg, SKB, Sweden; ENC2005 concluding remarks, by Larry Foulke, 'Nuclear Technology Matters'; Fuel crud formation and behavior, by Charles Turk, Entergy; and, Plant profile: major vote of confidence for NP, by Martti Katka, TVO, Finland.

How to manage sustainable supply chain? The issue of maturity

Directory of Open Access Journals (Sweden)

Agata Rudnicka

2016-12-01

Full Text Available Background: The issue of managing sustainability in supply chain seems to be more and more complex. There are many aspects that need to be taken into consideration when planning, implementing and monitoring environmental and social conditions of supply chains. Despite many works, already published, on the concept of sustainable development (SD is seems that the issue of assessment and especially the issue of maturity in the light of the SD concept is still not developed enough. Methods: The general aim of the paper is the analysis of the maturity issue in the context of sustainability. The main objective is to conceptualize the idea of maturity in sustainable supply chain. Beside the literature research the own proposition of theoretical model was described. Results: The article describes the issue of maturity as an element of managing sustainable development in the supply chain. The author presented a theoretical model of the maturity. Moreover the author gave some recommendations how to manage the sustainability issues in supply chain in more mature approach and introduced some useful tools among which are: certification, code of conduct and code of ethics, audits, projects etc. Conclusions: The issue of maturity seems to be very useful for proper understanding the idea of sustainable development in supply chain. The developed model can be used as self-assessment method to check at which level of implementation the idea of SD is analyzed in supply chain. Furthermore, the next phase of the planned research in form of practical verification of the model was advised as well as a research of identification of new factors and tools in analyzed area.

Issues for the long term management of radioactive waste

Energy Technology Data Exchange (ETDEWEB)

Schneider, T.; Schieber, C. [CEPN, 92 - Fontenay-aux-Roses (France); Lavelle, S. [ICAM, 59 - Lille (France)

2006-07-01

High-level radioactive waste are currently managed in interim storage installations, providing an adequate protection of the public and the workers for the short term period. However, the long-term persistence of the radioactivity of the waste gives a new timescale dimension, never experimented by the society for the development of protection systems. In the framework of the European Commission research project 'COWAM-2' (COmmunity WAste Management) dedicated to the governance of radioactive waste management, the issues of 'long term governance' have been addressed by exploring the elements which can contribute to a better integration of the technical and societal time dimensions, taking into account technical, ethical, economic and organizational considerations. The originality of this project is to address the various issues within working groups involving stakeholders from different origins and European countries together with a research team. After a discussion on the time dimensions to be taken into account from the technical and societal perspective, this paper presents, mainly based on the findings of the COWAM-2 project, a brief analysis of the ethical criteria to be considered when future generations are concerned as well as some performance criteria regarding long term governance. Finally, it proposes a discussion on the interest for the radiation protection experts to engage a process with stakeholders concerned by radioactive waste management in order to favour the emergence of a sustainable management responding to the issues at stake and including radiation protection considerations for long term periods. (authors)

Enhancing chronic disease management: a review of key issues and strategies.

Science.gov (United States)

Willison, Kevin D; Williams, Paul; Andrews, Gavin J

2007-11-01

This paper highlights three selected issues and potential strategies towards meeting chronic disease management needs. First, the orientation of the biomedical science model often gives insufficient attention to chronic health care needs. A second issue is that the use of complementary and alternative medicine (CAM) may offer for some an opportunity to enhance their chronic disease management efforts. A third issue is that our understanding of this potential is limited, as many who use CAM do not disclose such use. With reference to proposed solutions/strategies, first, an improved focus to respect patient/client values and goals may encourage people to disclose their use of CAM. Second, a community-based participatory approach shows promise in enhancing communication plus helps integrate CAM within new models of chronic disease management. Lastly, those in public health could help facilitate such an approach plus be a monitor of CAM practices. Overall, this review provides a springboard for further research and practice in CAM and the management of chronic diseases.

New Brunswick Market Design Committee : Congestion management issues

International Nuclear Information System (INIS)

2001-01-01

The restructuring of the New Brunswick wholesale power market comprises a number of issues that need to be resolved concerning transmission system related policy decisions and detailed design issues. The wholesale market structure, ownership structure, and means of preventing market power abuses all have an impact on the resolution of many of those issues. Some transmission related decisions regarding congestion management must be made, and they are examined in this document. The report includes a discussion of the issues related to congestion on the transmission system, a review of the decisions that remain to be made while proposing a number of alternatives, reviews decisions that other jurisdictions have made in somewhat similar circumstances. Finally, the advantages and disadvantages of each alternative are identified. Several high level transmission tariff design issues requiring to be addressed later in greater detail are listed in this document. 1 tab

Mind-Body Medicine and Immune System Outcomes: A Systematic Review.

Science.gov (United States)

Wahbeh, Helané; Haywood, Ashley; Kaufman, Karen; Zwickey, Heather

2009-01-01

This study is a systematic review of mind-body interventions that used immune outcomes in order to: 1) characterize mind-body medicine studies that assessed immune outcomes, 2) evaluate the quality of mind-body medicine studies measuring immune system effects, and 3) systematically evaluate the evidence for mind-body interventions effect on immune system outcomes using existing formal tools. 111 studies with 4,777 subjects were reviewed. The three largest intervention type categories were Relaxation Training (n=25), Cognitive Based Stress Management (n=22), and Hypnosis (n=21). Half the studies were conducted with healthy subjects (n=51). HIV (n=18), cancer (n=13) and allergies (n=7) were the most prominent conditions examined in the studies comprising of non-healthy subjects. Natural killer cell and CD4 T lymphocyte measures were the most commonly studied outcomes. Most outcome and modality categories had limited or inconclusive evidence. Relaxation training had the strongest scientific evidence of a mind-body medicine affecting immune outcomes. Immunoglobulin A had the strongest scientific evidence for positive effects from mind-body medicine. Issues for mind-body medicine studies with immune outcomes are discussed and recommendations are made to help improve future clinical trials.

Environmental issues in operations management

Science.gov (United States)

Muthulingam, Suresh

Adoption of sustainable operating practices is becoming an increasingly important issue for many organizations in the world today. In this dissertation, I use empirical methods to investigate factors that influence the adoption of sustainable practices and also identify issues that may hinder the adoption of such practices. I explore these issues in two diverse settings. In Chapter 1, I investigate the adoption and non-adoption of energy efficiency initiatives using a database of over 100,000 recommendations provided to more than 13,000 small and medium sized manufacturing firms. Even though the average payback across all recommendations is just over one year, many of these profitable opportunities are not implemented. Using a probit instrumental variable model, I identify four biases in the adoption of these recommendations. First, managers are myopic as they miss out on many profitable opportunities. Second, managers are more influenced by upfront costs than by net benefits when evaluating such initiatives. Third, adoption of a recommendation depends not only on its characteristics but also on the sequence in which the recommendations are presented. Adoption rates are higher for initiatives appearing early in a list of recommendations. Finally, adoption is not influenced by the number of options provided to decision makers. This contributes to the debate about whether or not choice overload occurs. We highlight decision biases previously unobserved in the Operations Management literature using field data rather than experimental data. We draw implications for enhancing adoption of energy efficiency initiatives and for other decision contexts where a collection of process improvement recommendations are made to firms. In Chapter 2, I examine the depth of adoption of the voluntary LEED (Leadership in Energy and Environmental Design) standards for green buildings. Depth of adoption refers to the extent to which the buildings adopt practices related to the standard

The challenges and issues facing the radioactive waste management in Croatia

International Nuclear Information System (INIS)

Subasic', D.; Saler, A.

1994-01-01

There are substantial experiences in Croatia in the field of radioactive waste management concerning both the waste from nuclear applications and waste generated at nuclear power plant. The essential issue now is how set-up infrastructure and to realize institutional and capacity building to get adjusted to needs of the newly independent state. In connection to this, the issues related to national radioactive waste management strategy, past and new organization of the Regulatory Body, and changes in legislation and regulations are discussed. In addition, some on-going projects important for realization of a complete radioactive waste management in the country round up the present situation in the field of radioactive waste management in Croatia

[Review of the 2016 Swiss immunization schedule and technology update for improving vaccine management].

Science.gov (United States)

Diana, Alessandro

2016-05-11

The 2016 immunization schedule published by the Swiss Federal Office of Public Health includes three new clauses: reimbursement of the additional Human Papillomavirus (HPV) vaccination in young males (11-26 years) as recommended by local canton programs, the end of franchise exemption for the measles, mumps and rubella (MMR) vaccination, and the creation of a new system of indemnities and moral compensation in the event of personal injury resulting from vaccinations. This article presents the main features of the 2016 immunization schedule with details of the technology available to physicians to improve vaccine management.

Waste Management Strategy in The Netherlands. Part 2. Strategy Principles and Influencing Issues

International Nuclear Information System (INIS)

Haverkate, B.R.W.

2002-01-01

This report reflects the Dutch input prepared in the framework of work package 2 of the EU thematic network COMPAS, which deals with the identification of alternative waste management strategies and issues influencing strategy selection in EU member states and their applicant countries. All elements that could have an effect in identifying alternative policies to manage (long-lived) radioactive wastes are addressed in this report. After a short introduction, in chapter 1, about some general issues influencing decision-making such as public acceptance, involvement, perception and (European) legislation, the considered disposal methods and disposal requirements are given in chapter 2. Chapter 3 of this report deals with the background topics of the current waste management strategy in The Netherlands. A detailed overview of (basic) strategy principles and their influencing issues is the subject of chapter 4. Issues considered include: safety and environmental impact; technical limitations; nuclear materials safeguards; monitoring and retrievability; ethical issues; public acceptance; (timing of) strategy development and implementation; and economical considerations. Relevant additional issues that could have an effect in identifying alternative waste management strategy are provided in appendices, including signed treaties (appendix B) and nuclear statutory regulations (appendix C)

Romiplostim for the Emergency Management of Severe Immune Thrombocytopenia with Intracerebral Hemorrhage

Directory of Open Access Journals (Sweden)

Romain Gellens

2018-01-01

Full Text Available Currently, we lack well-established guidelines for the emergency management of severe immune thrombocytopenia (ITP with life-threatening bleeding. We now report the management of two patients with severe ITP, complicated by substantial cerebral hemorrhage, requiring urgent surgery due to refractory intracranial hypertension. To rapidly boost platelet counts (PCs, corticosteroids, intravenous immunoglobulin, and iterative platelet transfusions were given; all were ineffectual. Romiplostim, a thrombopoietin receptor agonist, was then administered as an “on demand therapy,” with the result that a rapid and sustained increase of PCs was achieved, thus allowing for postoperative hemostasis. Both patients recovered good neurological condition, suggesting the potential utility of romiplostim, in combined therapy, for the emergency management of severe ITP.

Current Issues for Higher Education Information Resources Management.

Science.gov (United States)

CAUSE/EFFECT, 1996

1996-01-01

Issues identified as important to the future of information resources management and use in higher education include information policy in a networked environment, distributed computing, integrating information resources and college planning, benchmarking information technology, integrated digital libraries, technology integration in teaching,…

Adaptive management of natural resources-framework and issues

Science.gov (United States)

Williams, B.K.

2011-01-01

Adaptive management, an approach for simultaneously managing and learning about natural resources, has been around for several decades. Interest in adaptive decision making has grown steadily over that time, and by now many in natural resources conservation claim that adaptive management is the approach they use in meeting their resource management responsibilities. Yet there remains considerable ambiguity about what adaptive management actually is, and how it is to be implemented by practitioners. The objective of this paper is to present a framework and conditions for adaptive decision making, and discuss some important challenges in its application. Adaptive management is described as a two-phase process of deliberative and iterative phases, which are implemented sequentially over the timeframe of an application. Key elements, processes, and issues in adaptive decision making are highlighted in terms of this framework. Special emphasis is given to the question of geographic scale, the difficulties presented by non-stationarity, and organizational challenges in implementing adaptive management. ?? 2010.

Nurse managers' experience with ethical issues in six government hospitals in Malaysia: a cross-sectional study.

Science.gov (United States)

Musa, Maizura binti; Harun-Or-Rashid, M D; Sakamoto, Junichi

2011-11-16

Nurse managers have the burden of experiencing frequent ethical issues related to both their managerial and nursing care duties, according to previous international studies. However, no such study was published in Malaysia. The purpose of this study was to explore nurse managers' experience with ethical issues in six government hospitals in Malaysia including learning about the way they dealt with the issues. A cross-sectional study was conducted in August-September, 2010 involving 417 (69.2%) of total 603 nurse managers in the six Malaysian government hospitals. Data were collected using three-part self-administered questionnaire. Part I was regarding participants' demographics. Part II was about the frequency and areas of management where ethical issues were experienced, and scoring of the importance of 11 pre-identified ethical issues. Part III asked how they dealt with ethical issues in general; ways to deal with the 11 pre-identified ethical issues, and perceived stress level. Data were analyzed using descriptive statistics, cross-tabulations and Pearson's Chi-square. A total of 397 (95.2%) participants experienced ethical issues and 47.2% experienced them on weekly to daily basis. Experiencing ethical issues were not associated with areas of practice. Top area of management where ethical issues were encountered was "staff management", but "patient care" related ethical issues were rated as most important. Majority would "discuss with other nurses" in dealing generally with the issues. For pre-identified ethical issues regarding "patient care", "discuss with doctors" was preferred. Only 18.1% referred issues to "ethics committees" and 53.0% to the code of ethics. Nurse managers, regardless of their areas of practice, frequently experienced ethical issues. For dealing with these, team-approach needs to be emphasized. Proper understanding of the code of ethics is needed to provide basis for reasoning.

Waste management in space: a NASA symposium. Special issue

Science.gov (United States)

Wydeven, T. (Principal Investigator)

1991-01-01

This special issue contains papers from the NASA Symposium on Waste Processing for Advanced Life Support, which was held at NASA Ames Research Center on September 11-13, 1990. Specialists in waste management from academia, government, and industry convened to exchange ideas and advise NASA in developing effective methods for waste management in a Controlled Ecological Life Support System (CELSS). Innovative and well-established methods were presented to assist in developing and managing wastes in closed systems for future long-duration space missions, especially missions to Mars.

Cultural Issue and its Influence in the Management of Global Project Teams

Directory of Open Access Journals (Sweden)

Nadia Lima

2016-04-01

Full Text Available The interactions between the project manager and team members may be affected by several variables, such as culture, leadership style of the project manager, and the complexity of the developed tasks. Focused in this context, the objective of this paper is to investigate and describe how the culture issue can affect the anagement of global project teams. It is a qualitative, descriptive study conducted in a large multinational company in the automotive sector. The results of this research show that cultural issues can influence both positively and negatively the management of project global teams and the managers of these projects have to deal with several management challenges that require the adoption of certain ways of dealing with culture impacts in managing their teams to minimize potential problems in this context.

Editorial safety science special issue road safety management.

NARCIS (Netherlands)

Wegman, F.C.M. & Hagezieker, M.P.

2014-01-01

The articles presented in this Special Issue on Road Safety Management represent an illustration of the growing interest in policy-related research in the area of road safety. The complex nature of this type of research combined with the observation that scientific journals pay limited attention to

Towards Cloud Computing SLA Risk Management: Issues and Challenges

OpenAIRE

Morin, Jean-Henry; Aubert, Jocelyn; Gateau, Benjamin

2012-01-01

Cloud Computing has become mainstream technology offering a commoditized approach to software, platform and infrastructure as a service over the Internet on a global scale. This raises important new security issues beyond traditional perimeter based approaches. This paper attempts to identify these issues and their corresponding challenges, proposing to use risk and Service Level Agreement (SLA) management as the basis for a service level framework to improve governance, risk and compliance i...

Parametric Immunization in Bond Portfolio Management

OpenAIRE

Bravo, Jorge; Fonseca, José

2012-01-01

In this paper, we evaluate the relative immunization performance of the multifactor parametric interest rate risk model based on the Nelson-Siegel-Svensson specification of the yield curve with that of standard benchmark investment strategies, using European Central Bank yield curve data in the period between January 3, 2005 and December 31, 2011. In addition, we examine the role of portfolio design in the success of immunization strategies, particularly the role of the maturit...

Safeguards issues of long-term waste management at DOE sites

International Nuclear Information System (INIS)

Pillay, K.K.S.

1992-06-01

Waste management at US Department of Energy (DOE) sites is not often regarded as a safeguard-sensitive step in the nuclear fuel cycle because the material concerned is relatively unattractive for diversion or theft. However, the accumulation of large amounts of fissile materials in wastes over a period of time can be a safeguards concern. One estimate shows that high-level and transuranic wastes and some miscellaneous radioactive materials at DOE sites may contain as much as 15 Mt of fissile materials. In the context of present US strategies for the disposal of these radioactive wastes, this study identifies safeguards issues relevant to proposed scenarios for the long-term management and permanent disposal of the above-mentioned waste forms in geologic repositories. This study points out areas of concern and the need to examine the issues before the wastes are processed for geologic disposal. Good waste management practices may offer unique opportunities to address the safeguards issues identified here. A judicious approach to examining the safeguards requirements of waste disposal programs may also contribute to DOE's new effort to establish and maintain public confidence in its environmental restoration programs

U.S. Immunization program adult immunization activities and resources

Science.gov (United States)

Woods, LaDora O.; Bridges, Carolyn B.; Graitcer, Samuel B.; Lamont, Brock

2016-01-01

ABSTRACT Adults are recommended to receive vaccines based on their age, medical conditions, prior vaccinations, occupation and lifestyle. However, adult immunization coverage is low in the United States and lags substantially below Healthy People 2020 goals. To assess activities and resources designated for adult immunization programs by state and local health department immunization programs in the United States, we analyzed 2012 and 2013 data from the Centers for Disease Control and Prevention's (CDC) Program Annual Reports and Progress Assessments (PAPA) survey of CDC-funded immunization programs. Fifty-six of 64 funded US immunization programs' responses were included in the analysis. Eighty-two percent of (n = 46) programs reported having a designated adult immunization coordinator in 2012 and 73% (n = 41) in 2013. Of the 46 coordinators reported in 2012, 30% (n = 14) spent more than 50% of their time on adult immunization activities, and only 24% (n = 10) of the 41 adult coordinators in 2013 spent more than 50% of their time on adult immunization activities. In 2012, 23% (n = 13) of the 56 programs had a separate immunization coalition for adults and 68% (n = 38) included adult issues in their overall immunization program coalition. In 2013, 25% (n = 14) had a separate adult immunization coalition while 57% (n = 32) incorporated adult immunizations into their overall immunization program coalition. The results indicate substantial variation across the US in public health infrastructure to support adult immunizations. Continued assessment of adult immunization resources and activities will be important in improving adult immunization coverage levels though program support. With many programs having limited resources dedicated to improving adult immunization rates in the in US, efforts by the health departments to collaborate with providers and other partners in their jurisdictions to increase awareness, increase the use of proven strategies to improve

Muslim Scholars' Knowledge, Attitudes and Perceived Barriers Towards Polio Immunization in Pakistan.

Science.gov (United States)

Khan, Muhammad Umair; Ahmad, Akram; Salman, Saad; Ayub, Maria; Aqeel, Talieha; Haq, Noman-Ul; Saleem, Fahad; Khan, Muhammad Ubaid

2017-04-01

Pakistan is one of the two countries where polio remains endemic. Among multiple reasons of polio prevalence, false religious beliefs are accounted as major barriers towards polio immunization in Pakistan. Within this context, religious scholars are now engaged in polio immunization campaigns to dismantle the myths and battle the resurgence of polio in Pakistan. The objective of this study was to assess knowledge, attitudes and perceived barriers of Muslim scholars towards polio immunization in Pakistan. A descriptive, cross-sectional survey of Muslim scholars was conducted in Quetta and Peshawar divisions of Pakistan. From October to December 2015, a convenience sample of 770 Muslim scholars was recruited from the local mosques and religious institutions to participate in this study. Knowledge, attitudes, and perceived barriers were assessed by using self-administered, anonymous and pretested questionnaire. Descriptive and regression analyses were used to express the results with p polio with a mean score of 7.16 ± 2.12 (based on 14 questions). Knowledge gaps were identified about the transmission (32.6 %) and consequences of poliovirus (39.9 %). Overall, 527 (68.4 %) participants showed positive attitudes towards polio immunization with a mean attitude score of 27.35 ± 2.68 (based on nine statements). The majority of participants agreed on the need of depoliticizing polio immunization issues (87.1 %), while reservations were noted about their willingness to participate in future polio immunization programs (44.6 %). Security (75.8 %) and vaccine management issues (64 %) were reported by the participants as the major barriers towards polio immunization in Pakistan. The findings showed poor knowledge of Muslim scholars towards polio; however, their attitudes were positive towards polio immunization. More studies are required to assess the knowledge and attitudes of Muslim scholars at the national level to validate the findings of this study.

Sensitive issues in natural resource management and discursive strategies addressing them

NARCIS (Netherlands)

Kouevi, T.A.; Mierlo, van B.C.; Leeuwis, C.; Vodouhê, S.D.

2016-01-01

In natural resource management facilitation literature, little attention is paid to sensitive issues in multi-stakeholder interaction and learning. This article aims to fill this gap. It discusses the variety of discursive strategies used by stakeholders to address sensitive issues with regard to

Public Relations Manager Involvement in Strategic Issue Diagnosis.

Science.gov (United States)

Lauzen, Martha M.

1995-01-01

Reports on an exploratory study that seeks to build theoretical understanding of how public relations practitioner involvement in one type of strategic organizational decision making--strategic issue diagnosis--is related to shared values with top management, diagnosis accuracy, strategy pursued, and the power of the public relations function. (TB)

Harnessing the immune system through programmed death-1 blockade in the management of Hodgkin lymphoma

Directory of Open Access Journals (Sweden)

Oncale MB

2017-02-01

Full Text Available Melody B Oncale, Hossein Maymani, Loretta J Nastoupil Department of Lymphoma and Myeloma, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA Abstract: Immunotherapy is a rapidly evolving therapeutic option in the treatment of lymphoma. Neoplastic cells evade immune recognition through the programmed death (PD-1/PD-ligand immune checkpoint pathway. Several novel agents have been developed to restore the immune system’s ability to recognize and destroy cancer cells. Nivolumab and pembrolizumab are two anti-PD-1 antibodies that have demonstrated success in the treatment of refractory Hodgkin lymphoma. Harnessing the immune system’s ability to target neoplastic cells, ideally without the use of cytotoxic chemotherapeutic agents, is one way in which these novel agents are changing the therapeutic landscape in the treatment of lymphomas. Here, we review the emerging data regarding checkpoint inhibitors in the management of Hodgkin lymphoma, the unique adverse effects encountered with the use of these agents, and a practical approach to the management of these adverse effects. Additionally, we discuss upcoming trials that will further assess the promising future developments of checkpoint inhibition in the treatment of not only Hodgkin lymphoma but also other B cell lymphomas and myeloma. These agents offer immense promise of a future where many lymphomas can be treated without the toxic effects of chemotherapeutic agents. Keywords: Hodgkin lymphoma, programmed death-1, nivolumab, pembrolizumab, lymphoma

Road safety issues for bus transport management.

Science.gov (United States)

Cafiso, Salvatore; Di Graziano, Alessandro; Pappalardo, Giuseppina

2013-11-01

Because of the low percentage of crashes involving buses and the assumption that public transport improves road safety by reducing vehicular traffic, public interest in bus safety is not as great as that in the safety of other types of vehicles. It is possible that less attention is paid to the significance of crashes involving buses because the safety level of bus systems is considered to be adequate. The purpose of this study was to evaluate the knowledge and perceptions of bus managers with respect to safety issues and the potential effectiveness of various technologies in achieving higher safety standards. Bus managers were asked to give their opinions on safety issues related to drivers (training, skills, performance evaluation and behaviour), vehicles (maintenance and advanced devices) and roads (road and traffic safety issues) in response to a research survey. Kendall's algorithm was used to evaluate the level of concordance. The results showed that the majority of the proposed items were considered to have great potential for improving bus safety. The data indicated that in the experience of the participants, passenger unloading and pedestrians crossing near bus stops are the most dangerous actions with respect to vulnerable users. The final results of the investigation showed that start inhibition, automatic door opening, and the materials and internal architecture of buses were considered the items most strongly related to bus passenger safety. Brake assistance and vehicle monitoring systems were also considered to be very effective. With the exception of driver assistance systems for passenger and pedestrian safety, the perceptions of the importance of other driver assistance systems for vehicle monitoring and bus safety were not unanimous among the bus company managers who participated in this survey. The study results showed that the introduction of new technologies is perceived as an important factor in improving bus safety, but a better understanding

The management issues of implementing telecommuting: a case study

OpenAIRE

Bane, Chuck Howard, Jr.

1993-01-01

Approved for public release; distribution is unlimited. This thesis is a case study of the implementation of telecommuting by CalComp at the Telecommuting Workcenter of Riverside County and is a real life example of the management issues that surround telecommuting. The issues brought forth in this study will enable those responsible for implementing a telecommuting program to better understand the impact of this change on their organization and how a telecommuting center may be used in th...

Dialogue, Language and Identity: Critical Issues for Networked Management Learning

Science.gov (United States)

Ferreday, Debra; Hodgson, Vivien; Jones, Chris

2006-01-01

This paper draws on the work of Mikhail Bakhtin and Norman Fairclough to show how dialogue is central to the construction of identity in networked management learning. The paper is based on a case study of a networked management learning course in higher education and attempts to illustrate how participants negotiate issues of difference,…

Nutrition, immune function and health of dairy cattle.

Science.gov (United States)

Ingvartsen, K L; Moyes, K

2013-03-01

The large increase in milk yield and the structural changes in the dairy industry have caused major changes in the housing, feeding and management of the dairy cow. However, while large improvements have occurred in production and efficiency, the disease incidence, based on veterinary records, does not seem to be improved. Earlier reviews have covered critical periods such as the transition period in the cow and its influence on health and immune function, the interplay between the endocrine system and the immune system and nutrition and immune function. Knowledge on these topics is crucial for our understanding of disease risk and our effort to develop health and welfare improving strategies, including proactive management for preventing diseases and reducing the severity of diseases. To build onto this the main purpose of this review will therefore be on the effect of physiological imbalance (PI) on immune function, and to give perspectives for prevention of diseases in the dairy cow through nutrition. To a large extent, the health problems during the periparturient period relate to cows having difficulty in adapting to the nutrient needs for lactation. This may result in PI, a situation where the regulatory mechanisms are insufficient for the animals to function optimally leading to a high risk of a complex of digestive, metabolic and infectious problems. The risk of infectious diseases will be increased if the immune competence is reduced. Nutrition plays a pivotal role in the immune response and the effect of nutrition may be directly through nutrients or indirectly by metabolites, for example, in situations with PI. This review discusses the complex relationships between metabolic status and immune function and how these complex interactions increase the risk of disease during early lactation. A special focus will be placed on the major energetic fuels currently known to be used by immune cells (i.e. glucose, non-esterified fatty acids, beta

Social and Environmental Issues in Corporative Management: A Romanian Story

Directory of Open Access Journals (Sweden)

Cornelia DASCĂLU

2011-12-01

Full Text Available The complex process of monitoring entities environmental impact entails ability, respect for the environment and reduction of the ecological footprint. This research defines Romanian trends as regards the effects and actions to adapt to climate change and characterizes corporate management in terms of compliance with environmental management systems requirements. The main objective is to assess the current state of environmental management implementation and identifies relevant social and environmental issues that companies use to include in corporate management. The current agenda would allow developing a framework for environmental management implementation in Romanian entities, in order to assume the corporate social responsibility.

Conference communication. Managing change in tourism destinations: Key issues and current trends.

OpenAIRE

Mariani, M.M.; Buhalis, Dimitrios; Longhi, C.; Vitouladiti, O.

2013-01-01

This conference communication illustrates the major outcomes emerging from the EIASM Conference on Tourism Management and Tourism Related Issues held in Nice (France), September 20-21, 2012. While a number of managerial issues pertaining to the tourism field were dealt with, this communication covers three specific areas of interest for destination management and marketing: (1) the increasing competition among tourism destinations and the rise and consolidation of BRIC countries as outbound t...

Management of examinations: ethical issues. | Nweze | Edo Journal ...

African Journals Online (AJOL)

Talking about the ethical issues, we are all aware of the manner/way in which examination malpractice has eaten deep into the fabrics of our society. Some measures really have to be taken to normalize the examination system in our society. The challenges of examination management are numerous for example, having ...

Immunizations challenge healthcare personnel and affects immunization rates.

Science.gov (United States)

Strohfus, Pamela K; Kim, Susan C; Palma, Sara; Duke, Russell A; Remington, Richard; Roberts, Caleb

2017-02-01

This study measured 1. medical office immunization rates and 2. health care personnel competency in managing vaccine practices before and after evidence-based immunization education was provided. This descriptive study compared 32 family medicine and pediatric offices and 178 medical assistants, licensed practical nurses, registered nurses, nurse practitioners, and physicians in knowledge-based testing pre-education, post-education, and 12-months post-education. Immunization rates were assessed before and 18-months post-education. Immunization rates increased 10.3% - 18months post-education; knowledge increased 7.8% - 12months post-education. Family medicine offices, licensed practical nurses, and medical assistants showed significant knowledge deficits before and 12-months post-education. All demographic groups scored less in storage/handling 12-months post-education. This study is one of the first studies to identify competency challenges in effective immunization delivery among medical assistants, licensed practical nurses, and family medicine offices. Formal and continuous education in immunization administration and storage/handling is recommended among these select groups. Copyright © 2016 Elsevier Inc. All rights reserved.

Pwani Yetu: Issue 4. April 1999.Tanzania Coastal Management Partnership.

OpenAIRE

Tanzania Coastal Management Partnership

1999-01-01

The Newsletter of the Tanzania Coastal Management Partnership - Pwani Yetu - 'our coast', is produced every other month in both Kiswahili and English and circulated to all coastal management partners from national level, coastal communities and the private sector. Pwani Yetu reports on coastal and marine activities, including issues on conservation, environment, and social economic development. 'Research Group' TCMP.

Nuclear waste management in Canada : critical issues, critical perspectives

International Nuclear Information System (INIS)

Durant, D.; Fuji Johnson, G.

2009-01-01

As oil reserves decline and the environment takes centre stage in public policy discussions, the merits and dangers of nuclear power and nuclear waste management continue to be debated. Canada is intent on building more reactors to increase energy production without destroying the planet, but it and other nuclear energy-producing countries face not only technical problems but also social and ethical issues. This book provides a critical antidote to the favourable position of government and industry. The contributors build their case by exploring key issues and developments. What do frequently used terms such as safety, risk, and acceptability really mean? How and why did the public consultation process in Canada fail to address ethical and social issues? What is the significance and potential of a public consultation process that involves diverse interests, epistemologies, and actors, including Aboriginal peoples? And how do we ensure that our frameworks for discussion are inclusive and ethical? This timely collection defuses the uncertainty, ambiguity, and ignorance that surrounds nuclear energy. It will appeal to academics, students, and stakeholders in public policy or environmental studies who want to think critically and more broadly about how we approach energy generation and waste management.

The Radioactive Waste Management Advisory Committee's advice to ministers on radioactive waste management issues at UKAEA Dounreay

International Nuclear Information System (INIS)

1999-01-01

Topics discussed in the document include: problem areas in waste management; key facilities, operations and areas at Dounreay; social context, public communications and management issues at Dounreay. Background information and RWMAC review of Dounreay are given

Immunity: Insect Immune Memory Goes Viral.

Science.gov (United States)

Ligoxygakis, Petros

2017-11-20

Adaptive memory in insect immunity has been controversial. In this issue, Andino and co-workers propose that acquisition of viral sequences in the host genome gives rise to anti-sense, anti-viral piRNAs. Such sequences can be regarded as both a genomic archive of past infections and as an armour of potential heritable memory. Copyright © 2017 Elsevier Ltd. All rights reserved.

Overview of Contemporary Issues of Forest Research and Management in China

Science.gov (United States)

He, Hong S.; Shifley, Stephen R.; Thompson, Frank R.

2011-12-01

With 207 million ha of forest covering 22% of its land area, China ranks fifth in the world in forest area. Rapid economic growth, climate change, and forest disturbances pose new, complex challenges for forest research and management. Progress in meeting these challenges is relevant beyond China, because China's forests represent 34% of Asia's forests and 5% of the worlds' forests. To provide a broader understanding of these management challenges and of research and policies that address them, we organized this special issue on contemporary forest research and management issues in China. At the national level, papers review major forest types and the evolution of sustainable forestry, the development of China's forest-certification efforts, the establishment of a forest inventory system, and achievements and challenges in insect pest control in China. Papers focused on Northern China address historical, social, and political factors that have shaped the region's forests; the use of forest landscape models to assess how forest management can achieve multiple objectives; and analysis and modeling of fuels and fire behavior. Papers addressing Central and South China describe the "Grain for Green" program, which converts low productivity cropland to grassland and woodland to address erosion and soil carbon sequestration; the potential effects of climate change on CO2 efflux and soil respiration; and relationships between climate and net primary productivity. China shares many forest management and research issues with other countries, but in other cases China's capacity to respond to forest management challenges is unique and bears watching by the rest of the world.

Value issues and stakeholders' views in radioactive waste management

International Nuclear Information System (INIS)

Colglazier, E.W.; Dungan, D.L.; Reaven, S.J.

1987-01-01

The authors review a study in progress that is examining the role played by ethical and value issues in high-level and low-level radioactive waste management. For each policy issue, they attempt to separate its ''value concerns'' into three categories, called procedural, distributional, and evidential aspects. These categories refer to concerns about fairness and appropriateness of process, outcomes, and scientific evidence, respectively. For each value concern, attempt to state the rationale used by key stakeholder groups in justifying their policy positions and to extract the ''underlying general principles'' (UGP's) that appear to be the basis for the arguments. By examining patterns of UGP's across groups for an issue, and across issues for a group, the authors hope to explain the patterns of UGP's in terms of more fundamental attributes of stakeholders' ''world views'' and notions about science and society

Social and ethical issues in environmental risk management.

Science.gov (United States)

Oughton, Deborah H

2011-07-01

The recognition of the social and ethical aspects of radiation risk management has been an important part of international projects following the Chernobyl accident of 1986. This study comments on the science and policy issues in environmental risk assessment, including the social and ethical dimensions of emergency preparedness and remediation experiences gained from the Chernobyl accident. While the unique situation of Fukushima, combined with an earthquake and tsunami, raises its own social and political challenges, it is hoped that some of the lessons learnt from Chernobyl will be relevant to long-term management of the Fukushima site. Copyright © 2011 SETAC.

Operations Management of Logistics and Supply Chain: Issues and Directions

OpenAIRE

Li, Xiang

2014-01-01

There has been consensus that logistics as well as supply chain management is a vital research field, yet with few literature reviews on this topic. This paper sets out to propose some hot issues in the current research, through a review of related literature from the perspective of operations management. In addition, we generate some insights and future research directions in this field.

Pediatric issues in disaster management, part 2: evacuation centers and family separation/reunification.

Science.gov (United States)

Mace, Sharon E; Sharieff, Ghazala; Bern, Andrew; Benjamin, Lee; Burbulys, Dave; Johnson, Ramon; Schreiber, Merritt

2010-01-01

Although children and infants are likely to be victims in a disaster and are more vulnerable in a disaster than adults, disaster planning and management has often overlooked the specific needs of pediatric patients. We discuss key components of disaster planning and management for pediatric patients including emergency medical services, hospital/facility issues, evacuation centers, family separation/reunification, children with special healthcare needs, mental health issues, and overcrowding/surge capacity. Specific policy recommendations and an appendix with detailed practical information and algorithms are included. The first part of this three part series on pediatric issues in disaster management addresses the emergency medical system from the field to the hospital and surge capacity including the impact of crowding. The second part addresses the appropriate set up and functioning of evacuation centers and family separation and reunification. The third part deals with special patient populations: the special healthcare needs patient and mental health issues.

13 CFR 107.250 - Exclusion of stock options issued by Licensee from Management Expenses.

Science.gov (United States)

2010-01-01

... Sbic § 107.250 Exclusion of stock options issued by Licensee from Management Expenses. Stock options... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Exclusion of stock options issued by Licensee from Management Expenses. 107.250 Section 107.250 Business Credit and Assistance SMALL...

Immune Checkpoint Inhibitors: An Innovation in Immunotherapy for the Treatment and Management of Patients with Cancer.

Science.gov (United States)

Dine, Jennifer; Gordon, RuthAnn; Shames, Yelena; Kasler, Mary Kate; Barton-Burke, Margaret

2017-01-01

Cancer survival rates are generally increasing in the United States. These trends have been partially attributed to improvement in therapeutic strategies. Cancer immunotherapy is an example of one of the newer strategies used to fight cancer, which primes or activates the immune system to produce antitumor effects. The first half of this review paper concisely describes the cell mechanisms that control antitumor immunity and the major immunotherapeutic strategies developed to target these mechanisms. The second half of the review discusses in greater depth immune checkpoint inhibitors that have recently demonstrated tremendous promise for the treatment of diverse solid tumor types, including melanoma, non-small cell lung cancer, and others. More specifically, the mechanisms of action, side effects, and patient and family management and education concerns are discussed to provide oncology nurses up-to-date information relevant to caring for cancer-affected patients treated with immune checkpoint inhibitors. Future directions for cancer immunotherapy are considered.

Managing Your Seasonal Allergies | NIH MedlinePlus the Magazine

Science.gov (United States)

... this page please turn JavaScript on. Feature: Seasonal Allergies Managing Your Seasonal Allergies Past Issues / Spring 2015 Table of Contents Allergic ... and avoid collecting pollen on them. Fast Facts Allergies are reactions of your immune system to one ...

International trade and waste and fuel managment issue, 2008

Energy Technology Data Exchange (ETDEWEB)

Agnihotri, Newal (ed.)

2008-01-15

The focus of the January-February issue is on international trade and waste and fuel managment. Major articles/reports in this issue include: A global solution for clients, by Yves Linz, AREVA NP; A safer, secure and economical plant, by Andy White, GE Hitachi Nuclear; Robust global prospects, by Ken Petrunik, Atomic Energy of Canada Limited; Development of NPPs in China, by Chen Changbing and Li Huiqiang, Huazhong University of Science and Technology; Yucca Mountain update; and, A class of its own, by Tyler Lamberts, Entergy Nuclear. The Industry Innovation articles in this issue are: Fuel assembly inspection program, by Jim Lemons, Tennessee Valley Authority; and, Improved in-core fuel shuffle for reduced refueling duration, by James Tusar, Exelon Nuclear.

Telemental Health for Children and Adolescents: An Overview of Legal, Regulatory, and Risk Management Issues.

Science.gov (United States)

Kramer, Gregory M; Luxton, David D

2016-04-01

The use of technology to provide telemental healthcare continues to increase; however, little has been written about the legal and regulatory issues involved in providing this form of care to children and adolescents. This article reviews existing laws and regulations to summarize the risk management issues relevant to providing telemental healthcare to children and adolescents. There are several legal and regulatory areas in which telemental health clinicians need to have awareness. These areas include: 1) Licensure, 2) malpractice liability, 3) credentialing and privileging, 4) informed consent, 5) security and privacy, and 6) emergency management. Although legal and regulatory challenges remain in providing telemental healthcare to children and adolescents, it is possible to overcome these challenges with knowledge of the issues and appropriate risk management strategies. We provide general knowledge of these key legal and regulatory issues, along with some risk management recommendations.

Operations Management of Logistics and Supply Chain: Issues and Directions

Directory of Open Access Journals (Sweden)

Xiang Li

2014-01-01

Full Text Available There has been consensus that logistics as well as supply chain management is a vital research field, yet with few literature reviews on this topic. This paper sets out to propose some hot issues in the current research, through a review of related literature from the perspective of operations management. In addition, we generate some insights and future research directions in this field.

Solid Waste Management in Nigeria: Problems and Issues.

Science.gov (United States)

AGUNWAMBA

1998-11-01

/ This paper is a presentation of the problems of solid waste management in Nigeria and certain important issues that must be addressed in order to achieve success. At the core of the problems of solid waste management are the absence of adequate policies, enabling legislation, and an environmentally stimulated and enlightened public. Government policies on the environment are piecemeal where they exist and are poorly implemented. Public enlightenment programs lacked the needed coverage, intensity, and continuity to correct the apathetic public attitude towards the environment. Up to now the activities of the state environmental agencies have been hampered by poor funding, inadequate facilities and human resources, inappropriate technology, and an inequitable taxation system. Successful solid waste management in Nigeria will require a holistic program that will integrate all the technical, economic, social, cultural, and psychological factors that are often ignored in solid waste programs.KEY WORDS: Solid waste; Management; Problems; Solutions; Nigeria

Assessing Pharmacists' Attitudes and Barriers Involved with Immunizations

Directory of Open Access Journals (Sweden)

Sarah Aldrich

2014-01-01

Full Text Available Pharmacists are considered the most accessible health care professional. Immunizations create an opportunity for the profession to grow and develop toward direct patient care. Between 1995 and 2004 programs involving immunizations led to a national initiative to train pharmacists that became a significant leap toward pharmacist's involvement in direct patient care. Although immunizations can be considered a catalyst to change the pharmacist's role, little was known about pharmacist's attitudes and the barriers involved with immunizing. Few studies have assessed barriers, attitudes, and practice issues experienced by immunizing pharmacists. The objective of this study was to determine pharmacists' attitudes toward immunizations and more specifically to assess possible barriers involved with this practice. Five hundred pharmacists were randomly selected for inclusion in the study from the State of Ohio Board of Pharmacy Database, of which 137 (27.4% completed the survey. A 37- item questionnaire was administered via an e-mail invitation to take an online survey using Qualtrics software with a Likert-type scale, where 1 = strongly disagree and 7 = strongly agree. Several topics were assessed regarding immunizations including time constraints, workflow constraints, adequacy of training, technician support, worksite conditions and space, immunization processes, reimbursement issues, safety issues, documentation issues, and the future direction of immunizations. Demographics included gender, age, degree, number of years practicing, practice site, and number of years immunizing. Seventy-three percent of pharmacists believed that immunizing could lead to prescription filling errors (mean=4.45, SD=1.79. Pharmacists strongly agreed that having more technicians on staff would make providing immunizations easier (mean=5.80, SD=1.39 and that they play a vital role in keeping the process running smoothly (mean=6.08, SD=1.16. Also, pharmacists strongly agreed

School Discipline: Special Issues. School Management Handbook Number 2.

Science.gov (United States)

National Association of Elementary School Principals, Arlington, VA.

This part of the School Management Handbook provides the elementary school administrator with an overview of civil rights issues affecting school discipline policy. The first section treats the requirements for providing due process and avoiding discrimination against minority groups when following disciplinary procedures. Section 2 covers…

Nuclear waste management in Canada: critical issues, critical perspectives

National Research Council Canada - National Science Library

Johnson, Genevieve Fuji; Durant, Darrin

2009-01-01

... on FSC-certified ancient-forest-free paper (100 percent post-consumer recycled) that is processed chlorineand acid-free. Library and Archives Canada Cataloguing in Publication Nuclear waste management in Canada : critical issues, critical perspectives / edited by Darrin Durant and Genevieve Fuji Johnson. Includes bibliographical references an...

Purchasing & supply management for a sustainable world: Introduction to the IPSERA 2013 conference special issue

DEFF Research Database (Denmark)

Johnsen, T. E.; Giannakis, M.; Miemczyk, J.

2014-01-01

Special issue of best papers of the 22nd annual IPSERA conference 2013: Purchasing & Supply Management for a Sustainable World......Special issue of best papers of the 22nd annual IPSERA conference 2013: Purchasing & Supply Management for a Sustainable World...

VACCINES AND IMMUNIZATION: WORLD SITUATION

Directory of Open Access Journals (Sweden)

G.H. Brundtland

2007-01-01

Full Text Available The last issue of the report «vaccines and immunization: world situation» stresses considerable success in immunization at the global level since the mid 90 s — completely total eradication of poliomyelitis across the world, as well as the drastic reduction of the new measles and tetanus cases among mothers and newborns in some poor countries. The report also briefly describes the progress in the development and implementation of the new life saving vaccines, which may save millions of lives annually. The authors have explained some of the reasons, why the global community should invest in immunization, as well as the perspectives for the use of vaccines and immunization in future.Key words: vaccine, immunization, children.

Nonmotor fluctuations: phenotypes, pathophysiology, management, and open issues.

Science.gov (United States)

Classen, Joseph; Koschel, Jiri; Oehlwein, Christian; Seppi, Klaus; Urban, Peter; Winkler, Christian; Wüllner, Ullrich; Storch, Alexander

2017-08-01

Parkinson's disease (PD) is a neurodegenerative multisystem disorder characterized by progressive motor symptoms such as bradykinesia, tremor and muscle rigidity. Over the course of the disease, numerous non-motor symptoms, sometimes preceding the onset of motor symptoms, significantly impair patients' quality of life. The significance of non-motor symptoms may outweigh the burden through progressive motor incapacity, especially in later stages of the disease. The advanced stage of the disease is characterized by motor complications such as fluctuations and dyskinesias induced by the long-term application of levodopa therapy. In recent years, it became evident that various non-motor symptoms such as psychiatric symptoms, fatigue and pain also show fluctuations after chronic levodopa therapy (named non-motor fluctuations or NMFs). Although NMFs have moved into the focus of interest, current national guidelines on the treatment of PD may refer to non-motor symptoms and their management, but do not mention NMF, and do not contain recommendations on their management. The present article summarizes major issues related to NMF including clinical phenomenology and pathophysiology, and outlines a number of open issues and topics for future research.

Gender Issues in Theatre Management: The Cross-River State ...

African Journals Online (AJOL)

This study examined gender issues in the management of the Cross-River State Cultural Centre. Three research questions were formulated for the study and eighty-three respondents were used for the study. The researcher made use of questionnaires, interviews and group discussions for collecting data for the study.

Risk management in HIV/AIDS: ethical and economic issues ...

African Journals Online (AJOL)

Risk management in HIV/AIDS: ethical and economic issues associated with restricting HAART access only to adherent patients. ... Using the software TreeAge Pro 2009, we developed a Markov model to project economic outcomes for a hypothetical cohort of HIV/AIDS patients on HAART. The model compared two ...

Introduction to the Special Issue on Marketing and Operations Management Interfaces and Coordination

OpenAIRE

Teck H. Ho; Christopher S. Tang

2004-01-01

This special issue, by addressing problems surrounding marketing and operations management, depicts state-of-the-art approaches, methodologies, and insights to improve a firm's or supply chain's overall performance. Top scholars in the field address many of the ways in which companies can synchronize their marketing and operations departments or their supply chain partners to improve competitiveness and profit. The information in this issue should be of interest both to academics and managers...

Immune reactivity of candidate reference materials

NARCIS (Netherlands)

Fernandez-Rivas, Montserrat; Aalbers, Marja; Fötisch, Kay; de Heer, Pleuni; Notten, Silla; Vieths, Stefan; van Ree, Ronald

2006-01-01

Immune reactivity is a key issue in the evaluation of the quality of recombinant allergens as potential reference materials. Within the frame of the CREATE project, the immune reactivity of the natural and recombinant versions of the major allergens of birch pollen (Bet v 1), grass pollen (Phl p 1

Choosing Pre-conception Planning for Women/Families: Counselling and Informed Consent (Part 2) - Pre-conception Reproductive Planning, Lifestyle, Immunization, and Psychosocial Issues.

Science.gov (United States)

Wilson, R Douglas

2017-12-06

To inform reproductive and other health care providers about pre-conception evaluation, including considerations for reproductive planning, lifestyle modification, immunization status and attitudes, and psychosocial issues. This counselling information can be used for patient education and planning and possible pre-conception and/or prenatal testing. This information may allow for improved risk assessment when pre-conception counselling for individual patients and their families is used. CONSIDERATIONS FOR PRE-CONCEPTION CARE (PART 2) REGARDING PRE-CONCEPTION REPRODUCTIVE PLANNING, LIFESTYLE, IMMUNIZATIONS, AND PSYCHOSOCIAL ISSUES: CONSIDERATION FOR CARE STATEMENTS: For this review article, the Consideration for Care Statements use the Grading of Recommendations, Assessment, Development and Evaluations strength and quality principles because they are comparable for the clinician and the patient/public user. For example, "Strong" for clinicians is defined as "the recommendation would apply to most individuals. Formal discussion aids are not likely to be needed to help individuals make decisions consistent with their values and preferences." For patients/the public, "Strong" is defined as, "we believe most people in this situation would want the recommended course of actions and only a small number would not." Quality of evidence (High, Moderate, Low) is based on the confidence that the true effect lies close to that of the estimate of the effect. In addition, the Canadian Task Force on Preventive Health Care key to evidence statements and grading of recommendations are included. PubMed, Medline, and the Cochrane Database were searched until May 2017, using appropriate key words (i.e., preconception, reproductive planning, lifestyle modification, immunization risks and benefits, psychosocial pregnancy factors/issues). Grey (unpublished) literature was identified through searching websites of health technology assessment and health technology assessment

The Stop Transmission of Polio Data Management (STOP DM) assignment and its role in polio eradication and immunization data improvement in Africa

OpenAIRE

Benke, Amalia; Williams, Alford Joseph; MacNeil, Adam

2017-01-01

The availability and use of high quality immunization and surveillance data are crucial for monitoring all components of the Global Polio Eradication Program (GPEI). The Stop Transmission of Polio (STOP) program was initiated in 1999 to train and mobilize human resources to provide technical support to polio endemic and at-risk countries and in 2002 the STOP data management (STOP DM) deployment was created to provide capacity development in the area of data management for immunization and sur...

Emergency management in health: key issues and challenges in the UK.

Science.gov (United States)

Lee, Andrew C K; Phillips, Wendy; Challen, Kirsty; Goodacre, Steve

2012-10-19

Emergency planning in the UK has grown considerably in recent years, galvanised by the threat of terrorism. However, deficiencies in NHS emergency planning were identified and the evidence-base that underpins it is questionable. Inconsistencies in terminologies and concepts also exist. Different models of emergency management exist internationally but the optimal system is unknown. This study examines the evidence-base and evidence requirements for emergency planning in the UK health context. The study involved semi-structured interviews with key stakeholders and opinion leaders. Purposive sampling was used to obtain a breadth of views from various agencies involved in emergency planning and response. Interviews were then analysed using a grounded approach using standard framework analysis techniques. We conducted 17 key informant interviews. Interviewees identified greater gaps in operational than technical aspects of emergency planning. Social and behavioural knowledge gaps were highlighted with regards to how individuals and organisations deal with risk and behave in emergencies. Evidence-based approaches to public engagement and for developing community resilience to disasters are lacking. Other gaps included how knowledge was developed and used. Conflicting views with regards to the optimal configuration and operation of the emergency management system were voiced. Four thematic categories for future research emerged:(i) Knowledge-base for emergency management: Further exploration is needed of how knowledge is acquired, valued, disseminated, adopted and retained.(ii) Social and behavioural issues: Greater understanding of how individuals approach risk and behave in emergencies is required.(iii) Organisational issues in emergencies: Several conflicting organisational issues were identified; value of planning versus plans, flexible versus standardized procedures, top-down versus bottom-up engagement, generic versus specific planning, and reactive versus

Gender Issues in the Management of Infertility in Developing Countries

African Journals Online (AJOL)

Gender Issues in the Management of Infertility in Developing Countries. Editorial. Infertility ... heritage has become morbidly adherent in the mind of even the highly ... the respondents preferred male to female children, and this was attributed to ...

[Stress and auto-immunity].

Science.gov (United States)

Delévaux, I; Chamoux, A; Aumaître, O

2013-08-01

The etiology of auto-immune disorders is multifactorial. Stress is probably a participating factor. Indeed, a high proportion of patients with auto-immune diseases report uncommon stress before disease onset or disease flare. The biological consequences of stress are increasingly well understood. Glucocorticoids and catecholamines released by hypothalamic-pituitary-adrenal axis during stress will alter the balance Th1/Th2 and the balance Th17/Treg. Stress impairs cellular immunity, decreases immune tolerance and stimulates humoral immunity exposing individuals to autoimmune disease among others. The treatment for autoimmune disease should include stress management. Copyright © 2012 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

Risk Management: An Analysis of Issues in Islamic Financial Industry (Occasional Paper)

OpenAIRE

Khan, Tariqullah; Ahmed, Habib

2001-01-01

The paper discusses a number of risk management issues of the Islamic financial industry. It outlines the risk management processes and techniques that enable financial institutions to control undesirable risks and to take benefit of the business opportunities created by the desirable ones.

A systematic review of ethical issues in vaccine studies involving pregnant women.

Science.gov (United States)

Beeler, Jennifer A; Lambach, Philipp; Fulton, T Roice; Narayanan, Divya; Ortiz, Justin R; Omer, Saad B

2016-08-02

Immunization during pregnancy can provide protection for mother and child. However, there have been only a limited number of studies documenting the efficacy and safety of this strategy. To determine the extent and nature of subject matter related to ethics in maternal immunization by systematically documenting the spectrum of ethical issues in vaccine studies involving pregnant women. We conducted a systematic literature review of published works pertaining to vaccine and therapeutic studies involving pregnant women through searches of PubMed, EMBASE, Web of Science, the Cochrane Database, and ClinicalTrials.gov. We selected literature meeting the inclusion criteria published between 1988 and June 2014. We systematically abstracted subject matter pertaining to ethical issues in immunization studies during pregnancy. Immunization-specific ethical issues were matched and grouped into major categories and subcategories. Seventy-seven published articles met the inclusion criteria. Published articles reported findings on data that had been collected in 26 countries, the majority of which were classified as high-income or upper-middle-income nations according to World Bank criteria. Review of these publications produced 60 immunization-specific ethical issues, grouped into six major categories. Notably, many studies demonstrated limited acknowledgment of key ethical issues including the rights and welfare of participants. Additionally, there was no discussion pertaining to the ethics of program implementation, including integration of maternal immunization programs into existing routine immunization programs. This review of ethical issues in immunization studies of pregnant women can be used to help inform future vaccine trials in this important population. Consistent documentation of these ethical issues by investigators will facilitate a broader and more nuanced discussion of ethics in immunization of pregnant women - offering new and valuable insights for programs

Immune Aspects of Female Infertility

Directory of Open Access Journals (Sweden)

Andrea Brazdova

2016-05-01

Full Text Available Immune infertility, in terms of reproductive failure, has become a serious health issue involving approximately 1 out of 5 couples at reproductive age. Semen that is defined as a complex fluid containing sperm, cellular vesicles and other cells and components, could sensitize the female genital tract. The immune rejection of male semen in the female reproductive tract is explained as the failure of natural tolerance leading to local and/or systemic immune response. Present active immune mechanism may induce high levels of anti-seminal/sperm antibodies. It has already been proven that iso-immunization is associated with infertility. Comprehensive studies with regards to the identification of antibody-targets and the determination of specific antibody class contribute to the development of effective immuno-therapy and, on the other hand, potential immuno-contraception, and then of course to complex patient diagnosis. This review summarizes the aspects of female immune infertility.

In search of balance – managing the dualities of HRM: an overview of the issues

NARCIS (Netherlands)

Boselie, J.P.P.E.F.|info:eu-repo/dai/nl/177012277; Brewster, C.; Paauwe, J.

2009-01-01

Purpose – The purpose of this paper is to provide an overview of the human resource management (HRM) literature that builds up to our current concern with dualities, paradoxes, ambiguities, and balance issues; and to introduce the six papers in this special issue on managing the dualities in HRM.

Optimizing national immunization program supply chain management in Thailand: an economic analysis.

Science.gov (United States)

Riewpaiboon, A; Sooksriwong, C; Chaiyakunapruk, N; Tharmaphornpilas, P; Techathawat, S; Rookkapan, K; Rasdjarmrearnsook, A; Suraratdecha, C

2015-07-01

This study aimed to conduct an economic analysis of the transition of the conventional vaccine supply and logistics systems to the vendor managed inventory (VMI) system in Thailand. Cost analysis of health care program. An ingredients based approach was used to design the survey and collect data for an economic analysis of the immunization supply and logistics systems covering procurement, storage and distribution of vaccines from the central level to the lowest level of vaccine administration facility. Costs were presented in 2010 US dollar. The total cost of the vaccination program including cost of vaccine procured and logistics under the conventional system was US$0.60 per packed volume procured (cm(3)) and US$1.35 per dose procured compared to US$0.66 per packed volume procured (cm(3)) and US$1.43 per dose procured under the VMI system. However, the findings revealed that the transition to the VMI system and outsourcing of the supply chain system reduced the cost of immunization program at US$6.6 million per year because of reduction of un-opened vaccine wastage. The findings demonstrated that the new supply chain system would result in efficiency improvement and potential savings to the immunization program compared to the conventional system. Copyright © 2015 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.

Nuclear waste management: A review of issues

International Nuclear Information System (INIS)

Angino, E.E.

1985-01-01

The subject of radioactive waste management and burial is a subject that raises strong emotional and political issues and generates sharp technical differences of opinion. The overall problem can be subdivided into the three major categories of (1) credibility and emotionalism, (2) technology, and (3) nuclear waste isolation and containment. An area of concern desperately in need of attention is that of proper public education on all aspects of the high-level radioactive-waste (rad-waste) burial problem. A major problem related to the rad-waste issue is the apparent lack of an official, all-encompassing U.S. policy for nuclear waste management, burial, isolation, and regulation. It is clear from all past technical reports that disposal of rad wastes in an appropriate geologic horizon is the best ultimate solution to the waste problem. After 25 y of dealing with the high-level radioactive waste problem, the difficulty is that no proposed plan has to date been tested properly. It is this indecision and reaction that has contributed in no small way to the public perception of inability to solve the problem. One major change that has occurred in the last few years was the enactment of the Nuclear Waste Policy Act of 1982. This act mandates deadlines, guidelines, and state involvement. It is time that strong differences of opinions be reconciled. One must get on with the difficult job of selecting the best means of isolating and burying these wastes before the task becomes impossible

Essays on issues relevant to the regulation of radioactive waste management

International Nuclear Information System (INIS)

Bishop, W.P.; Hoos, I.R.; Hilberry, N.; Metlay, D.S.; Watson, R.A.

1978-05-01

This document contains a collection of essays prepared by the individuals who participated in a Special Task Group for the U.S. Nuclear Regulatory Commission (NRC) for the purpose of identifying and proposing goals (or guiding principles) for the regulation of radioactive waste management. The report of the Special Task group to the NRC is contained in 'Proposed Goals for Radioactive Waste Management'. The titles of the essays are as follows: History and interpretation of radioactive waste management in the United States; The credibility issue; Assessment of methodologies for radioactive waste management; Remarks on managerial errors and public participation; Observations and impressions on the nature of radioactive waste management problems; and Goals for nuclear waste management

Issues and scenarios for nuclear waste management systems analysis

International Nuclear Information System (INIS)

Mendel, J.E.

1980-11-01

The Planning and Analysis Branch of the Department of Energy's Nuclear Waste Management Programs is developing a new systems integration program. The Pacific Northwest Laboratory was requested to perform a brief scoping analysis of what scenarios, questions, and issues should be addressed by the systems integration program. This document reports on that scoping analysis

Managing Government Property Assets: The Main Issues From The Malaysian Perspective

Directory of Open Access Journals (Sweden)

Shardy Abdullah

2011-09-01

Full Text Available The Malaysian federal government is largely responsible towards providing several facilities to the community. The development of various types of property assets which encompasses buildings and infrastructure such as office buildings, roads, bridges and others, has proved that the government is really committed in executing its responsibility. From time to time, the number of property assets that were developed by the government is increasing parallel with the government's desire to stabilize its service quality. Nevertheless, in managing those property assets, the government currently is facing a mixture of problems and pitfalls such as the increase of property management and maintenance costs, the occurrence of incompatible maintenance programs, underutilization of property, end-user dissatisfaction and others. Following this scenario, the study was done with the main objective is to determine the management factors that are hindering the implementation of property management activities. A total of 67 respondents from ministries and technical departments were selected. The data was collected through a survey using questionnaire forms. The collected data was then analyzed using quantitative approaches such as frequency analysis method, mean analysis, relative important index as well as others. Results from the analysis show that there are 5 main management issues in managing Malaysian government owned property assets. Those issues are lack of proper property unit/department within a ministry, lack of expertise, lack of proper strategies, lack of proper management procedure and lack of IT usage.

Review on Malaysian Rail Transit Operation and Management System: Issues and Solution in Integration

Science.gov (United States)

Masirin, Mohd Idrus Mohd; Salin, Aminah Mohd; Zainorabidin, Adnan; Martin, David; Samsuddin, Norshakina

2017-08-01

In any context, operation and management of transportation systems are key issues which may affect both life quality and economic development. In large urban agglomerations, an efficient public transportation system may help abate the negative externalities of private car use such as congestion, air and noise pollution, accident and fuel consumption, without excessively penalizing user travel times or zone accessibility. Thus, this study is conducted to appraise the Malaysian rural rail transit operation and management system, which are considered important as there are many issues and solution in integration of the services that need to be tackled more conscientiously. The purpose of this paper is to describe some of the most important issues on integration of services and rail transit system in Malaysian and how to solve or reduce these problems and conflicts. In this paper, it consists of the historical development of rail transit construction in Malaysia. This paper also attempts to identify the important issues related to rail transit services and integration in Malaysian rural rail operation and management system. Comparison is also conducted with other countries such as UK, France, and Japan. Finally, a critical analysis is presented in this paper by looking at the possible application for future Malaysian rail transit operation system and management, especially focusing on enhancing the quality of Malaysian rural rail transit. In conclusion, this paper is expected to successfully review and appraise the existing Malaysian rural rail transit operation and management system pertaining to issues & solution in integration. It is also hoped that reformation or transformation of present service delivery quality of the rail transit operation and management will enable Malaysia to succeed in transforming Malaysian transportation system to greater heights.

Nuclear Knowledge Management Implementation Issues In Sri Lanka

International Nuclear Information System (INIS)

Bandara, H.M.N.R.

2014-01-01

About Knowledge Management: Process of organizing and distributing an Organization’s collective wisdom so the right information gets to the right people at the right time. NKM Implementation Problems in Sri Lanka: • Difficulty of identifying nuclear knowledge holders; • NKM has not been given considerable importance; • Many nuclear science experts are in retirement age; • No proper mechanism is available to replace young personnel for their positions; • Unawareness of general public about his technology. • Capacity building through training and education and transferring knowledge from centers of knowledge to centers of growth are key issues. • Development of new courses related to nuclear science is a key issue to be highly considered. • The tendency towards the training and educations of nuclear personnel in the country is becoming less and less

How Managing Editors View and Deal with Newspaper Ethical Issues.

Science.gov (United States)

Anderson, Douglas

1987-01-01

Claims there is awareness and concern about journalism ethics among daily newspaper managing editors. Asserts that although ethical issues are being addressed to some degree, greater efforts could be made to see that reporters and editors are apprised of codes of ethics. (MM)

Madawaska River water management review : issues, concerns, solutions

International Nuclear Information System (INIS)

1999-01-01

Public consultations were held by the Public Advisory Committee, the Ontario Ministry of Natural Resources (MNR) and Ontario Hydro (OH) Working Group and Steering Committee, in an effort to develop a water management system for the Madawaska River, that would address public interests such as public safety, maintenance of the aquatic ecosystem and hydroelectric power generation. Provision of long-term opportunities for broad public involvement in the river's management was an additional objective. The report emphasizes the importance of limiting conflicts between hydroelectric generation and recreation/tourism on the Madawaska River, which runs within the Madawaska Highlands, Algonquin Provincial Park and the Upper Ottawa Valley. The major competing uses for water management in the Madawaska River are: (1) hydroelectric generation, (2) flood control, (3) recreation and tourism, and (4) fish and aquatic ecosystems. Each of these are described in detail, with details of the responses to the issue description and recommended actions

77 FR 40817 - Low-Level Radioactive Waste Regulatory Management Issues

Science.gov (United States)

2012-07-11

...-2011-0012] RIN-3150-AI92 Low-Level Radioactive Waste Regulatory Management Issues AGENCY: Nuclear... regulatory time of compliance for a low-level radioactive waste disposal facility, allowing licensees the... system, and revising the NRC's licensing requirements for land disposal of radioactive waste. DATES: The...

Proceedings of conference on public policy issues in nuclear waste management

Energy Technology Data Exchange (ETDEWEB)

1976-01-01

This conference was designed to provide a public forum in which to identify and discuss the legal, institutional, social, environmental, and other public policy issues relating to nuclear waste management. This volume is a comprehensive synthesis of the speeches, papers, and discussions during the plenary and luncheon sessions. Preliminary goals are proposed for nuclear waste management. Separate abstracts were prepared for the ten papers. (DLC)

Management of ethical issues related to care of seriously ill dialysis patients in free-standing facilities.

Science.gov (United States)

Song, Mi-Kyung; Hanson, Laura C; Gilet, Constance A; Jo, Minjeong; Reed, Teresa J; Hladik, Gerald A

2014-09-01

There are few data on the frequency and current management of clinical ethical issues related to care of seriously ill dialysis patients in free-standing dialysis facilities. To examine the extent of clinical ethical challenges experienced by care providers in free-standing facilities and their perceptions about how those issues are managed. A total of 183 care providers recruited from 15 facilities in North Carolina completed a survey regarding the occurrence and management of ethical issues in the past year. Care plan meetings were observed at four of the facilities for three consecutive months. Also, current policies and procedures at each of the facilities were reviewed. The two most frequently experienced challenges involved dialyzing frail patients with multiple comorbidities and caring for disruptive/difficult patients. The most common ways of managing ethical issues were discussions in care plan meetings (n = 47) or discussions with the clinic manager (n = 47). Although policies were in place to guide management of some of the challenges, respondents were often not aware of those policies. Also, although participants reported that ethical issues related to dialyzing undocumented immigrants were fairly common, no facility had a policy for managing this challenge. Participants suggested that all staff obtain training in clinical ethics and communication skills, facilities develop ethics teams, and there be clear policies to guide management of ethical challenges. The scope of ethical challenges was extensive, how these challenges were managed varied widely, and there were limited resources for assistance. Multifaceted efforts, encompassing endeavors at the individual, facility, organization, and national levels, are needed to support staff in improving the management of ethical challenges in dialysis facilities. Copyright © 2014 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.

Overcoming Challenges to Childhood Immunizations Status.

Science.gov (United States)

Sabnis, Svapna S; Conway, James H

2015-10-01

Vaccines are one of the greatest public health achievements, preventing both mortality and morbidity. However, overall immunization rates are still below the 90% target for Healthy People 2020. There remain significant disparities in immunization rates between children of different racial/ethnic groups, as well as among economically disadvantaged populations. There are systemic issues and challenges in providing access to immunization opportunities. In addition, vaccine hesitancy contributes to underimmunization. Multiple strategies are needed to improve immunization rates, including improving access to vaccines and minimizing financial barriers to families. Vaccine status should be assessed and vaccines given at all possible opportunities. Copyright © 2015 Elsevier Inc. All rights reserved.

Ethical issues in patient safety: Implications for nursing management.

Science.gov (United States)

Kangasniemi, Mari; Vaismoradi, Mojtaba; Jasper, Melanie; Turunen, Hannele

2013-12-01

The purpose of this article is to discuss the ethical issues impacting the phenomenon of patient safety and to present implications for nursing management. Previous knowledge of this perspective is fragmented. In this discussion, the main drivers are identified and formulated in 'the ethical imperative' of patient safety. Underlying values and principles are considered, with the aim of increasing their visibility for nurse managers' decision-making. The contradictory nature of individual and utilitarian safety is identified as a challenge in nurse management practice, together with the context of shared responsibility and identification of future challenges. As a conclusion, nurse managers play a strategic role in patient safety. Their role is to incorporate ethical values of patient safety into decision-making at all levels in an organization, and also to encourage clinical nurses to consider values in the provision of care to patients. Patient safety that is sensitive to ethics provides sustainable practice where the humanity and dignity of all stakeholders are respected.

The people factor: An analysis of the human resources landscape for immunization supply chain management.

Science.gov (United States)

Kasonde, Musonda; Steele, Pamela

2017-04-19

Human resources is the backbone of any system and the key enabler for all other functions to effectively perform. This is no different with the Immunization Supply Chain, more so in todays' complex operating environment with the increasing strain caused by new vaccines and expanding immunization programmes (Source: WHO, UNICEF). In order to drive the change that is required for sustainability and continuous improvement, every immunization supply chain needs an effective leader. A dedicated and competent immunization supply chain leader with adequate numbers of skilled, accountable, motivated and empowered personnel at all levels of the health system to overcome existing and emerging immunization supply chain (ISC) challenges. Without an effective supply chain leader supported by capable and motivated staff, none of the interventions designed to strengthen the supply chain can be effective or sustainable (Source: Gavi Alliance SC Strategy 2014). This landscape analysis was preceded by an HR Evidence Review (March 2014) and has served to inform global partner strategies and country activities, as well as highlight where most support is required. The study also aimed to define the status quo in order to create some form of baseline against which to measure the impact of interventions related to HR going forward. The analysis was comprised of a comprehensive desk review, a survey of 40 respondents from 32 countries and consultations with ISC practitioners in several forums. The findings highlight key areas that should inform the pillars of a HR capacity development plan. At the same time, it revealed that there are some positive examples of where countries are actively addressing some of the issues identified and putting in place mechanisms and structures to optimize the SC function. Copyright © 2017. Published by Elsevier Ltd.

How do supervisors perceive and manage employee mental health issues in their workplaces?

Science.gov (United States)

Kirsh, Bonnie; Krupa, Terry; Luong, Dorothy

2018-01-01

Organizations have become increasingly concerned about mental health issues in the workplace as the economic and social costs of the problem continue to grow. Addressing employees' mental health problems and the stigma that accompanies them often falls to supervisors, key people in influencing employment pathways and the social climate of the workplace. This study examines how supervisors experience and perceive mental illness and stigma in their workplaces. It was conducted under the mandate of the Mental Health Commission of Canada's Opening Minds initiative. The study was informed by a theoretical framework of stigma in the workplace and employed a qualitative approach. Eleven supervisors were interviewed and data were analyzed for major themes using established procedures for conventional content analysis. Themes relate to: perceptions of the supervisory role relative to managing mental health problems at the workplace; supervisors' perceptions of mental health issues at the workplace; and supervisors' experiences of managing mental health issues at work. The research reveals the tensions supervisors experience as they carry out responsibilities that are meant to benefit both the individual and workplace, and protect their own well-being as well. This study emphasizes the salience of stigma and mental health issues for the supervisor's role and illustrates the ways in which these issues intersect with the work of supervisors. It points to the need for future research and training in areas such as balancing privacy and supports, tailoring disclosure processes to suit individuals and workplaces, and managing self-care in the workplace.

Strategic issue diagnosis : the roles of organizational scanning, information processing structure of top management teams, and managers' cognitive complexity

OpenAIRE

Kuvaas, Bård

1998-01-01

Managers in organizations are continuously confronted by an array of ambiguous data and -vaguely felt stimuli which they must somehow order, explicate and imbue with meaning before they decide on how to respond. This study of -162 -members of organizations' top management teams employed a cross-level analysis to investigate how individual-, group- and organizational-level factors relate to how managers diagnose strategic issues. Findings show that managers' cognitive style, the...

Environmental Management Accounting in the Taiwanese Higher Education Sector: Issues and Opportunities

Science.gov (United States)

Chang, Huei-Chun

2013-01-01

Purpose: The purpose of this paper is to address the issue of managing the major environmental costs from an accounting perspective. The current state of practices for managing the costs associated with the consumption of electricity, water and paper, as well as the generation of wastes within three universities in Taiwan, was investigated. The…

International trade and waste and fuel management issue, 2009

Energy Technology Data Exchange (ETDEWEB)

Agnihotri, Newal (ed.)

2009-01-15

The focus of the January-February issue is on international trade and waste and fuel managment. Major articles/reports in this issue include: Innovative financing and workforce planning, by Donna Jacobs, Entergy Nuclear; Nuclear power - a long-term need, by John C. Devine, Gerald Goldsmith and Michael DeLallo, WorleyParsons; Importance of loan guarantee program, by Donald Hintz; EPC contracts for new plants, by Dave Barry, Shaw Power Group; GNEP and fuel recycling, by Alan Hanson, AREVA NC Inc.; Safe and reliable reactor, by Kiyoshi Yamauchi, Mitsubishi Heavy Industries, Ltd.; Safe, small and simple reactors, by Yoshi Sakashita, Toshiba Corporation; Nuclear power in Thailand, by Tatchai Sumitra, Thailand Institute of Nuclear Technology; and, Nuclear power in Vietnam, by Tran Huu Phat, Vietnam Atomic Energy Commission. The Industry Innovation article this issue is Rectifying axial-offset-anomaly problems, by Don Adams, Tennessee Valley Authority. The Plant Profile article is Star of Stars Excellence, by Tyler Lamberts, Entergy Nuclear Operations, Inc.

A site specific approach to life cycle managment of labour rights issues

DEFF Research Database (Denmark)

Dreyer, Louise Camilla

not beyond dismissing suppliers and sub-contractors located in high risk environments. Balancing feasibility on one hand and reliability and relevance of results on the other hand is the challenge for a Social LCA method supporting life cycle management. This presentation offers a toolbox for prioritisation...... issues in the product chain through dialogue and partnership. The presented work is based on 5 years of research and practical CSR work in a globally operating Danish Corporation.......It can be observed from companies’ public sustainability commitments and increasing participation in voluntary social responsibility or accountability initiatives like Global Compact and ISO26000 or certification schemes like SA8000 that management of labour rights issues in the product chain...

Risk communication, geoethics and decision science issues in Japan's disaster management system

Science.gov (United States)

Sugimoto, M.

2014-12-01

Issues in Japan's disaster management system were revealed by the 2011 Tohoku earthquake and tsunami, and by the Fukushima Dai-ichi nuclear power station accident. Many important decisions were based on scientific data, but appear not to have sufficiently considered the uncertainties of the data and the societal aspects of the problems. The issues that arose show the need for scientists to appropriately deal with risk communication and geoethics and issues. This paper discusses necessity of　education for risk communication, geoethics and decisions science in school before students become sicentific decision makers in future.

Using network properties to evaluate targeted immunization algorithms

Directory of Open Access Journals (Sweden)

Bita Shams

2014-09-01

Full Text Available Immunization of complex network with minimal or limited budget is a challenging issue for research community. In spite of much literature in network immunization, no comprehensive research has been conducted for evaluation and comparison of immunization algorithms. In this paper, we propose an evaluation framework for immunization algorithms regarding available amount of vaccination resources, goal of immunization program, and time complexity. The evaluation framework is designed based on network topological metrics which is extensible to all epidemic spreading model. Exploiting evaluation framework on well-known targeted immunization algorithms shows that in general, immunization based on PageRank centrality outperforms other targeting strategies in various types of networks, whereas, closeness and eigenvector centrality exhibit the worst case performance.

Making Informed Decisions: Management Issues Influencing Computers in the Classroom.

Science.gov (United States)

Strickland, James

A number of noninstructional factors appear to determine the extent to which computers make a difference in writing instruction. Once computers have been purchased and installed, it is generally school administrators who make management decisions, often from an uninformed pedagogical orientation. Issues such as what hardware and software to buy,…

Workplace violence: managing a culture of acceptance.

Science.gov (United States)

Fredrick, Marie

2014-01-01

The cultural acceptance of workplace violence is changing. Management has become more educated on regulatory issues around its tolerance of workplace violence. Events around the country in a variety of settings have aided in raising awareness of this issue. Healthcare professionals are not immune to workplace violence, including those working in the imaging profession. Healthcare workers, historically, have given care despite the demeanor of patients, often putting up with aggressive behavior including sexual harassment and physical assault. Management needs to take all possible measures to ensure employees feel safe at work. It is essential to have well thought out policies and procedures to mitigate workplace violence; keeping in mind that a goal of eliminating workplace violence is unrealistic.

Public understanding of radioactive waste management issues: Perspectives and the IAEA's role

International Nuclear Information System (INIS)

Thomas, K.T.; Squires, D.J.

1989-01-01

This paper will address the waste disposal issue as it is one of the important ones being raised concerning acceptance of nuclear power. In a discussion of this issue two facts have to be recognized. The first is that wastes already exist in all countries having nuclear programmes and require safe management and disposal. The second is that adequate technology exists for doing this

Using the Collective Wisdom of Frontline Employees in Strategic Issue Management

DEFF Research Database (Denmark)

Lund Pedersen, Carsten

The field of strategic management has long alluded to the idea that lower-level employees immersed in the day-to-day business have experiential insights of potential strategic value. This line of thought has predominantly been supported by anecdotal evidence and explored in meticulous case studies...... to uncover the evolutionary traits of autonomous ventures. In a related vein, studies of ‘strategic issue management’ (SIM) tried to uncover organizational processes to identify emerging issues in volatile environments and devise proper strategic responses. These conceptual models were introduced in the very...... first volume of ‘Strategic Management Journal’, but little empirical research has since tried to develop the conception of SIM. An underlying research aim of this dissertation is to address and bridge these two literature streams, honing the idea of utilizing the collective wisdom possessed by frontline...

Public and political issues in radioactive waste management in the Federal Republic of Germany

International Nuclear Information System (INIS)

Neis, A.

1993-01-01

The Federal Government's radioactive waste management concept and regulations governing formal public participation in licensing procedures for radioactive waste management facilities are presented. The paper focuses on public and political issues arising from widely diverging views in different social groups on nuclear energy and on radioactive waste management. The resulting conflict between Federal and Laender (Federal constituent states) authorities and the actual course of public participation in a licensing procedure are illustrated with the example of planned final disposal of radioactive waste in the Konrad mine. Major national efforts to overcome the unsatisfying present situation are presented and the role of international consensus is briefly touched. Concluding remarks will particularly justify admissibility and emphasize the need to discuss and eventually decide on radioactive waste management issues regardless of diverging views on nuclear energy

Inter-regional Knowledge Management Workshop on Life-cycle Management of Design Basis Information – Issues, Challenges, Approaches. Presentations

International Nuclear Information System (INIS)

2013-01-01

This Workshop had a strategic focus on identifying and clarifying long-term issues and objectives related to our collective responsibilities to ensure that both existing nuclear facilities and future new build projects properly address life-cycle management of plant design basis knowledge (i.e. from design to decommissioning). The workshop attempted to bring together key stakeholders and build a better collective understanding, recognizing that very different perspectives exist and there are a wide range of national contexts and approaches. The various issues and challenges related to this topic and facing the nuclear energy sector both today and in the long-term were discussed in a senior management context and at strategic level

INTRODUCTION TO THE SPECIAL ISSUE ON "OPERATIONAL RESEARCH AND ASIA RISK MANAGEMENT"

OpenAIRE

DESHENG DASH WU; DAVID L. OLSON; LUIS A. SECO; JOHN BIRGE

2011-01-01

Risks are traditionally defined as the combination of probability and severity, but are actually characterized by additional factors. We believe the characteristics of risks include uncertainties, dynamics, dependence, clusterings and complexities, which motivate the utilization of various operational research tools. The objective of this issue is to survey the practice of using operational research tools in risk management, especially Asian risk management.

Confined Site Construction: A qualitative investigation of critical issues affecting management of Health and Safety

OpenAIRE

Spillane, John P.; Oyedele, Lukumon O.; Von Meding, Jason; Konanahalli, Ashwini; Jaiyeoba, Babatunde E.; Tijani, Iyabo K.

2011-01-01

The construction industry is inherently risky, with a significant number of accidents and disasters occurring, particularly on confined construction sites. This research investigates and identifies the various issues affecting successful management of health and safety in confined construction sites. The rationale is that identifying the issues would assist the management of health and safety particularly in inner city centres which are mostly confined sites. Using empiricism epistemology, th...

Special Issue: Current Trends in Research in Accounting Finance and Management Control

OpenAIRE

Lassala, Carlos; Ripoll Feliu, Vicente

2017-01-01

On January 27, 2016, an agreement was signed with OmniaScience to select articles to be published in the journal Intangible Capital, in a special issue titled "Current Trends in Research in Accounting, Finance and Management Control." The agreement was reached within the framework of three events at the University of Valencia, from June 27 to 30, 2016: XXI Workshop on Accounting and Management Control. “Memorial Raymond Konopka”, X Iberoamerican Congress of Management Accounting, III  Int...

A Buffer Management Issue in Designing SSDs for LFSs

Science.gov (United States)

Kim, Jaegeuk; Seol, Jinho; Maeng, Seungryoul

This letter introduces a buffer management issue in designing SSDs for log-structured file systems (LFSs). We implemented a novel trace-driven SSD simulator in SystemC language, and simulated several SSD architectures with the NILFS2 trace. From the results, we give two major considerations related to the buffer management as follows. (1) The write buffer is used as a buffer not a cache, since all write requests are sequential in NILFS2. (2) For better performance, the main architectural factor is the bus bandwidth, but 332MHz is enough. Instead, the read buffer makes a key role in performance improvement while caching data. To enhance SSDs, accordingly, it is an effective way to make efficient read buffer management policies, and one of the examples is tracking the valid data zone in NILFS2, which can increase the data hit ratio in read buffers significantly.

The nation's first consortium to address waste management issues

International Nuclear Information System (INIS)

Mikel, C.J.

1991-01-01

On July 26, 1989, the secretary of the Department of Energy (DOE), Admiral James Watkins, announced approval of the Waste-Management Education and Research Consortium (WERC). The consortium is composed of New Mexico State University (NMSU), the University of New Mexico, the New Mexico Institute of Mining and Technology, Los Alamos National Laboratory, and Sandia National Laboratories. This pilot program is expected to form a model for other regional and national programs. The WERC mission is to expand the national capability to address issues associated with the management of hazardous, radioactive, and solid waste. Research, technology transfer, and education/training are the three areas that have been identified to accomplish the objectives set by the consortium. The members of the consortium will reach out to the DOE facilities, other government agencies and facilities, and private institutions across the country. Their goal is to provide resources for solutions to waste management problems

Chaos Theory as a Model for Managing Issues and Crises.

Science.gov (United States)

Murphy, Priscilla

1996-01-01

Uses chaos theory to model public relations situations in which the salient feature is volatility of public perceptions. Discusses the premises of chaos theory and applies them to issues management, the evolution of interest groups, crises, and rumors. Concludes that chaos theory is useful as an analogy to structure image problems and to raise…

Super-enhancers: Asset management in immune cell genomes.

Science.gov (United States)

Witte, Steven; O'Shea, John J; Vahedi, Golnaz

2015-09-01

Super-enhancers (SEs) are regions of the genome consisting of clusters of regulatory elements bound with very high amounts of transcription factors, and this architecture appears to be the hallmark of genes and noncoding RNAs linked with cell identity. Recent studies have identified SEs in CD4(+) T cells and have further linked these regions to single nucleotide polymorphisms (SNPs) associated with immune-mediated disorders, pointing to an important role for these structures in the T cell differentiation and function. Here we review the features that define SEs, and discuss their function within the broader understanding of the mechanisms that define immune cell identity and function. We propose that SEs present crucial regulatory hubs, coordinating intrinsic and extrinsic differentiation signals, and argue that delineating these regions will provide important insight into the factors and mechanisms that define immune cell identity. Copyright © 2015 Elsevier Ltd. All rights reserved.

Visiting students work with professors to research water resources management issues

OpenAIRE

Davis, Lynn

2009-01-01

Undergraduate students visiting from universities across the continent, as well as one from Virginia Tech, are working with professors at Virginia Tech on individual research projects in a 10-week summer program that addresses issues related to sustainable management of water resources.

The benefit of issue management: anticipating crises in the digital age

NARCIS (Netherlands)

Strauβ, N.; Jonkman, J.

2017-01-01

Purpose The purpose of this paper is to find out how issue management and media monitoring is exercised in the digital age to anticipate crises. More specifically, it was investigated how these practices differ across communication professionals, organizations, and sectors in the Netherlands.

MANAGEMENT AND TREATMENT OF WATER FROM HARD-ROCK MINES {ENGINEERING ISSUE}

Science.gov (United States)

This Engineering Issue document on treatment of mining waters is a practical guide to understanding and selecting technologies for the environmental management of waste materials and effluents at hard-rock mines. For the purposes of this discussion, hard-rock mining primarily ref...

Managing the nation's high-level radioactive waste: key issues and recommendations

International Nuclear Information System (INIS)

1981-07-01

To date, no unified national plan has been adopted to develop and implement a comprehensive system of management and disposal of high-level radioactive waste in the United States. Growing public concern about this problem has resulted in a number of recent efforts to develop a national high-level waste management policy. The 96th Congress strove to resolve the central issues, but ultimately failed to pass legislation, partly because of disagreements about the appropriate role of states in the siting of repositories for military waste. Outside government, a number of organizations convened representatives of diverse groups concerned with national high-level radioactive waste management to seek agreement on the major elements of national policy. One such organization was RESOLVE, Center for Environmental Conflict Resolution, which in May 1981 was merged into The Conservation Foundation. RESOLVE convened Forum II, a series of discussions among representatives of environmental, industrial, governmental, and citizen interest groups, in 1981 specifically to address the issues blocking Congressional agreement on high-level waste policy. This report contains the recommendations which resulted from these deliberations. Reprocessing, interim storage, respository development, and licensing requirements are addressed. Federal, state, and public participation in decision making are also discussed

Special issue review of pollution prevention management within the Department of Energy, final report

International Nuclear Information System (INIS)

1994-08-01

The Department of Energy's (DOE) national role and overall mission has been undergoing significant change. In the post-Cold War era, a new emphasis on cleaning up the wastes from the past has emerged. These changes provide both significant challenges as well as new opportunities for DOE. While the challenges may seem overwhelming as DOE realizes the magnitude of its environmental problems, its network of national laboratories and sites provide the resources to become a leader in environmental management through the development of new technologies and management practices. Because of the growing importance of pollution prevention in the United States and more specifically to DOE's environmental management strategy, the Office of Environmental Audit (EH-24) identified this as an area worthy of a Special Issue Review. A Special Issue Review is not an audit but rather an in-depth review of key environmental programs or activities which cut across organizational boundaries. The purpose of a Special Issue Review is to identify strengths and weaknesses of a program as well as significant crosscutting issues or challenges that are important to the future success of that program. The scope of the review included an assessment of pollution prevention program activities at Headquarters, selected operations offices, and selected sites offices and contractor organizations. All aspects of a pollution prevention program were considered including program strategy, infrastructure, management systems, and implementation practices. Also summarized are future pollution prevention challenges and recommendations

An MCNP simulation for API applications to waste management issues

International Nuclear Information System (INIS)

Tunnell, L.N.

1994-01-01

Issues associated with waste management have increasingly become a focal point of attention for both the government and private sector since the end of the cold war. The problem are difficult to solve; the solutions are expensive to implement. Consequently, the development of a data simulation system capable of predicting the performance of a real system can save many thousands of dollars in travel expenses, optimization of experimental parameters, etc.. In this effort, computer codes were developed to simulate the production of associated particle imaging data so that its performance in a typical waste management application can be assessed

International trade and waste and fuel managment issue, 2007

Energy Technology Data Exchange (ETDEWEB)

Agnihotri, Newal (ed.)

2007-01-15

The focus of the January-February issue is on international trade and waste and fuel managment. Major articles/reports in this issue include: New plants with high safety and availability, by Bill Poirier, Westinghouse Electric Company; Increased reliability and competitiveness, by Russell E. Stachowski, GE Energy, Nuclear; Fuel for long-term supply of nuclear power, by Kumiaki Moriya, Hitachi, Ltd., Japan; Super high burnup fuel, By Noboru Itagaki and Tamotsu Murata, Nuclear Fuel Industries LTD., Japan; Zero fuel failures by 2010, by Tom Patten, AREVA NP Inc.; Decommissioning opportunities in the UK, by David Brown and William Thorn, US Department of Commerce; Industry's three challenges, by Dale E. Klein, US Nuclear Regulatory Commission; and, A step ahead of the current ABWR's, compiled by Claire Zurek, GE Energy.

Discussion on several issues of the accidents management of nuclear power plants in operation

International Nuclear Information System (INIS)

Cao Xuewu; Wang Zhe; Zhang Yingzhen

2009-01-01

This article discusses several issues of the accident management of nuclear power plants in operation, for example: the necessity, implementation principle of accident management and accident management program etc. For conducting accident management for beyond design basis accidents, this article thinks that the accident management program should be developed and implemented to ensure that the plant and its personnel with responsibilities for accident management are adequately prepared to take effective on-site actions to prevent or mitigate the consequences of severe accident. (authors)

Clinical management issues vary by specialty in the Victorian Audit of Surgical Mortality: a retrospective observational study

OpenAIRE

Vinluan, Jessele; Retegan, Claudia; Chen, Andrew; Beiles, Charles Barry

2014-01-01

Objective Clinical management issues are contributory factors to mortality. The aim of this study was to use data from the Victorian Audit of Surgical Mortality (VASM), an educational peer-review process for surgeons, to discover differences in the incidence of these issues between surgical specialties in order to focus attention to areas of care that might be improved. Design This study used retrospectively analysed observational data from VASM. Clinical management issues between eight speci...

Teaching an Issues-Based Interdisciplinary Course: Diversity in Management and Marketing

Science.gov (United States)

Hazen, Mary Ann; Higby, Mary A.

2005-01-01

The authors examine their experiences of coteaching an intensive, interdisciplinary elective course for MBA students: Diversity in Management and Marketing. They address otherness, dialogue, energy, and change within this course and clarify issues that can arise when coteaching interdisciplinary courses. The authors list implications for…

The Identity Crisis. Security, Privacy and Usability Issues in Identity Management

NARCIS (Netherlands)

Alpár, G.; Hoepman, J.H.; Siljee, B.I.J.

2011-01-01

This paper studies the current "identity crisis" caused by the substantial security, privacy and usability shortcomings encountered in existing systems for identity management. Some of these issues are well known, while others are much less understood. This paper brings them together in a single,

Human Resource Management in Sports: A Critical Review of its Importance and Pertaining Issues

Directory of Open Access Journals (Sweden)

Weerakoon Ranjan Kumara

2016-03-01

Full Text Available This paper will illustrate the meaning and importance of human resource management (HRM, human resource planning, and strategic human resource management, which are critically important for an organization’s effectiveness and must be effectively managed (Doherty, 1998. This study used the literature review method to acquire its final results. The relevant HRM literature review was done according to the purpose of the study. It used the purposive random sample method for selecting relevant literature. This study shows the current economic environment in the sports industry; the second part of the study critically analyzes the value of the strategic management of employees for the effective and efficient operation of sports organizations. It also critically evaluates human resource planning and other pertinent issues in terms of legislation, recruitment, selection, training, induction, and reward management from different international examples in sports management. Over the past few decades, increasing competition, globalization, and continuous changes in the market and in technology have emphasized the need to rethink the management of the organization and of human resources for the sake of overcoming significant challenges (Taylor et al., 2006. Therefore, managers should use strategic human resource management to overcome significant issues and to form well-planned strategies so that the organization may succeed.

Review of issues relevant to acceptable risk criteria for nuclear waste management

International Nuclear Information System (INIS)

Cohen, J.J.

1978-01-01

Development of acceptable risk criteria for nuclear waste management requires the translation of publicly determined goals and objectives into definitive issues which, in turn, require resolution. Since these issues are largely of a subjective nature, they cannot be resolved by technological methods. Development of acceptable risk criteria might best be accomplished by application of a systematic methodology for the optimal implementation of subjective values. Multi-attribute decision analysis is well suited for this purpose

Childhood immunization: when physicians and parents disagree.

Science.gov (United States)

Gilmour, Joan; Harrison, Christine; Asadi, Leyla; Cohen, Michael H; Vohra, Sunita

2011-11-01

Persistent fears about the safety and efficacy of vaccines, and whether immunization programs are still needed, have led a significant minority of parents to refuse vaccination. Are parents within their rights when refusing to consent to vaccination? How ought physicians respond? Focusing on routine childhood immunization, we consider the ethical, legal, and clinical issues raised by 3 aspects of parental vaccine refusal: (1) physician counseling; (2) parental decision-making; and (3) continuing the physician-patient relationship despite disagreement. We also suggest initiatives that could increase confidence in immunization programs.

PPARγ Agonists in Adaptive Immunity: What Do Immune Disorders and Their Models Have to Tell Us?

Directory of Open Access Journals (Sweden)

Laurindo Ferreira da Rocha Junior

2013-01-01

Full Text Available Adaptive immunity has evolved as a very powerful and highly specialized tool of host defense. Its classical protagonists are lymphocytes of the T- and B-cell lineage. Cytokines and chemokines play a key role as effector mechanisms of the adaptive immunity. Some autoimmune and inflammatory diseases are caused by disturbance of the adaptive immune system. Recent advances in understanding the pathogenesis of autoimmune diseases have led to research on new molecular and therapeutic targets. PPARγ are members of the nuclear receptor superfamily and are transcription factors involved in lipid metabolism as well as innate and adaptive immunity. PPARγ is activated by synthetic and endogenous ligands. Previous studies have shown that PPAR agonists regulate T-cell survival, activation and T helper cell differentiation into effector subsets: Th1, Th2, Th17, and Tregs. PPARγ has also been associated with B cells. The present review addresses these issues by placing PPARγ agonists in the context of adaptive immune responses and the relation of the activation of these receptors with the expression of cytokines involved in adaptive immunity.

Call for Papers – Special issue: Project Management in the Non-Profit Sector

OpenAIRE

Sankaran, Shankar

2015-01-01

This journal special issue will explore diverse stakeholder perspectives and share examples of project management practices in the non-profit sector. Key objectives are to develop understandings of project management practice in the sector, to examine how cross-sectoral collaboration and learning can help non-profit organisations achieve their project and programme objectives, and to explore ways in which the wider project management community can learn from experiences in the non-profit sector.

Intervening: Managerial Issues and Challenges in an Educational Management Development Program.

Science.gov (United States)

Barrilleaux, Louis E.; Schermerhorn, John R., Jr.

The literature on intervention theory tends to overlook the pragmatic managerial issues and challenges of intervening. This paper analyzes the formative period of a school management development program to establish crucial differences between the program director's espoused theory and the actual experience of the intervention. These differences…

Harmonization of industrial and oilfield waste management issues in Alberta

International Nuclear Information System (INIS)

Halla, S.

1999-01-01

There has been an ongoing discussion concerning the harmonization of waste management requirements within Alberta between the Alberta Energy and Utilities Board (EUB) and Alberta Environment (AENV), with the ultimate goal of publishing a memorandum of understanding (MOU) that will lay out the division of responsibilities between the two authorities on this matter. An overview is included of waste management in Alberta and of the harmonization agreements attained to date, with a stress on oil field waste issues. The EUB and AENV developed a MOE on the harmonization of waste management in Alberta, and a discussion is made of the concept of equivalency, which is used in the development of 'EUB guide 58: oilfield waste management requirements for the upstream petroleum industry' and will be a guiding principle for the MOU. Although the EUB's processes for waste management will not be exactly the same as AENV's, the EUB has made the commitment that, as a minimum, the requirements will provide the same level of environmental protection and public safety equivalent to that provided by AENV

Risk management and organizational systems for high-level radioactive waste disposal: Issues and priorities

International Nuclear Information System (INIS)

Emel, J.; Cook, B.; Kasperson, R.; Brown, H.; Guble, R.; Himmelberger, J.; Tuller, S.

1988-09-01

The discussion to follow explores the nature of the high-level radioactive waste disposal tasks and their implications for the design and organizational structure of effective risk management systems. We organize this discussion in a set of interrelated tasks that draw upon both relevant theory and accumulated experience. Specifically these tasks are to assess the management implications of the high levels of technical and social uncertainty that characterize the technology and mission; to identify the elements of organizational theory that bear upon risk management system design; to explore these theoretical issues in the context of two hypothetical risk scenarios associated with radioactive waste disposal; to consider the appropriate role of engineered and geological barriers; to examine briefly issues implicit in DOE's past waste management performance, with special attention to the Hanford facility; and to suggest findings and recommendations that require further attention. 74 refs

The Stop Transmission of Polio Data Management (STOP DM) assignment and its role in polio eradication and immunization data improvement in Africa.

Science.gov (United States)

Benke, Amalia; Williams, Alford Joseph; MacNeil, Adam

2017-01-01

The availability and use of high quality immunization and surveillance data are crucial for monitoring all components of the Global Polio Eradication Program (GPEI). The Stop Transmission of Polio (STOP) program was initiated in 1999 to train and mobilize human resources to provide technical support to polio endemic and at-risk countries and in 2002 the STOP data management (STOP DM) deployment was created to provide capacity development in the area of data management for immunization and surveillance data for these countries. Since 2002, Africa has received the majority of support from the STOP DM program, with almost 80% of assignments being placed in African countries. The STOP DM program has played a valuable role in improving the quality and use of data for the GPEI and has increasingly supported other immunization program data needs. In this report we provide an overview of the history, current status, and future of the STOP DM program, with a specific focus on the African continent.

Climate and transboundary water management issues

International Nuclear Information System (INIS)

Bjonback, D.

1991-01-01

The potential effects of climate change on transboundary river systems, major water uses, interjurisdictional arrangements, and water issues affecting water management in the Great Plains of Canada are discussed. Three atmospheric general circulation models (GCM) have been applied for a two times carbon dioxide concentration scenario for the Saskatchewan River system. The models were the Goddard Institute for Space Studies (GISS) model, the Geophysical Fluid Dynamics Laboratory (GFDL) model, and the Oregon State University (OSU) model. For all models, soil moisture on the plains was reduced. The GISS model predicted slightly higher runoff for plains-originating streams, and a substantial increase in runoff (32%) in the Rockies. The GFDL model predicted lower runoffs in the plains and Rockies, with some locations near the Alberta-Saskatchewan border indicating zero runoff. The OSU model results generally bracketed the GISS and GFDL results, with total runoff approximating 1951-1980 mean. The GISS model indicated an increase in net basin supply of 28%, while the GFDL model, due to lower runoff and high soil moisture defecits, showed a decrease of 38%. For policy making, monitoring, and research, the GFDL model results can provide important guidelines. Greater attention to demand management and conservation will have short-term benefits in stretching the limited water resource base to support a larger economy, while providing flexibility to cope with future climate as it evolves. 1 ref

Issues in NASA Program and Project Management. Special Report: 1997 Conference. Project Management Now and in the New Millennium

Science.gov (United States)

Hoffman, Edward J. (Editor); Lawbaugh, William M. (Editor)

1997-01-01

Topics Considered Include: NASA's Shared Experiences Program; Core Issues for the Future of the Agency; National Space Policy Strategic Management; ISO 9000 and NASA; New Acquisition Initiatives; Full Cost Initiative; PM Career Development; PM Project Database; NASA Fast Track Studies; Fast Track Projects; Earned Value Concept; Value-Added Metrics; Saturn Corporation Lessons Learned; Project Manager Credibility.

Polio Endgame, Information Gaps Related to Vaccines and Immunity.

Science.gov (United States)

Ahmad, Mohammad; Bahl, Sunil; Kunwar, Abhishek

2016-08-07

Evidence generated through research studies has guided programmatic actions and fine-tuned strategies for the Global Polio Eradication Initiative (GPEI). However, many gaps still persist in the understanding of a risk-free implementation of the polio endgame. Immediate concerns relate to the introduction of inactivated polio vaccine (IPV) and switch from trivalent oral polio vaccine (tOPV) to bivalent oral polio vaccine (bOPV) in routine immunization schedule. A comprehensive understanding of mucosal immunity in populations and best response options against circulating vaccine derived poliovirus (cVDPV) outbreaks in post tOPV-bOPV switch is essential to mitigate the risks of wild and vaccine-derived poliovirus importations and emergence of cVDPVs in polio-free countries. A clearer picture is also needed on few operational issues, interference between polio vaccines and other EPI vaccines and products related to polio endgame. It is also extremely important to develop mechanisms to identify and manage long-term poliovirus excretors who may pose a risk of reintroduction into the population after global eradication of poliovirus.

A review study of maintenance and management issues in Malaysian commercial building towards sustainable future practice

Science.gov (United States)

Nawi, Mohd Nasrun Mohd; Baharum, Faizal; Ibrahim, Siti Halipah; Riazi, Salman Riazi Mehdi

2017-10-01

Good management of the building will be able to influence the quality of the buildings that remain long, safe and beautiful without any damage and problems. This research paper aims to explore the issue of maintenance and management that appear in managing the commercial building in Malaysian construction and property industry. The data in this research has been gathered through the reviewing process of secondary data such as journals, proceeding, thesis etc. in the area that related to maintenance and management issue in commercial building. As highlighted by previous study, building a good management can ensure that the facilities available in the building are well and meet the standard. Thus, exposure to the problems and needs in the management of the building would be able to improve the quality of building management systems to be more effective and fulfil the client needs and features.

Managing ethical issues in sexual violence research using a pilot study

Directory of Open Access Journals (Sweden)

S.E. Duma

2009-09-01

Full Text Available Conducting research in the area of sexual violence has complex ethical and practical challenges for the researcher. Managing ethical issues in sexual violence is important and can be achieved through the use of pilot studies. The primary purpose of the pilot study was to identify and manage potential ethical and practical problems that could jeopardise the main study or violate the ethical and human rights of participants in the main study on women’s journey of recovery from sexual assault. The secondary purpose was to collect preliminary data in order to determine the human, financial and time resources needed for a planned study. The methods and processes used in conducting the pilot study in the study on women’s journey of recovery are discussed according to each of the objectives of the pilot study, methods used to achieve the objective, observations or findings made during the pilot study, and implications for the main study. This article aims to demonstrate how a pilot study was used to manage identified potential ethical and practical research issues during the recruitment of participants and data collection for the research that was conducted by the first author to investigate women’s journey of recovery from sexual assault trauma within the first week following sexual assault.

Issues in radioactive waste management for fusion power

International Nuclear Information System (INIS)

Maninger, R.C.; Dorn, D.W.

1983-01-01

Analysis of recent conceptual designs reveals that commercial fusion power systems will raise issues of occupational and public health and safety. This paper focuses on radioactive wastes from fusion reactor materials activated by neutrons. The analysis shows that different selections of materials and neutronic designs can make differences in orders-of magnitude of the kinds and amounts of radioactivity to be expected. By careful and early evaluation of the impacts of the selections on waste management, designers can produce fusion power systems with radiation from waste well below today's limits for occupational and public health and safety

Issues in radioactive-waste management for fusion power

International Nuclear Information System (INIS)

Maninger, R.C.; Dorn, D.W.

1982-01-01

Analysis of recent conceptual designs reveals that commercial fusion power systems will raise issues of occupational and public health and safety. This paper focuses on radioactive wastes from fusion reactor materials activated by neutrons. The analysis shows that different selections of materials and neutronic designs can make differences in orders-of-magnitude of the kinds and amounts of radioactivity to be expected. By careful and early evaluation of the impacts of the selections on waste management, designers can produce fusion power systems with radiation from waste well below today's limits for occupational and public health and safety

Education in Radioactive Waste Management: Issues of science, technology and society

International Nuclear Information System (INIS)

James, E.O.

1993-01-01

Public acceptance of matters relating to radioactive waste management can properly be sought through education, but what are the particulars to be considered and what is the strategy for success? The issues of science, technology and society which must be addressed are explored here and seen to be inextricably related, so that none of them can gain adequate attention except it be presented in the context of the others. Such issues include the concept of acceptable levels of risk, which must become familiar and applied with no greater severity to the nuclear industry than to other aspects of life

Issues in the Relationship between Theory and Practice in Management Accounting

DEFF Research Database (Denmark)

Baldvinsdottir, Gudrun; Mitchell, Falconer; Nørreklit, Hanne

2010-01-01

In recent decades the interest of academic researchers in the practical aspects of management accounting has waned. This editorial explores some of the reasons of this development. Over the past few decades we have witnessed the establishment of management accounting in academia as a social science....... This has increased the credibility of the accounting academics. However, it has also meant that academic researchers have neglected the technical core of their discipline and its problems and issues which have a direct practical relevance. It is concluded that there is a need for academic researchers...

Multidisciplinary Management of Spondyloarthritis-Related Immune-Mediated Inflammatory Disease.

Science.gov (United States)

Rizzello, Fernando; Olivieri, Ignazio; Armuzzi, Alessandro; Ayala, Fabio; Bettoli, Vincenzo; Bianchi, Luca; Cimino, Luca; Costanzo, Antonio; Cristaudo, Antonio; D'Angelo, Salvatore; Daperno, Marco; Fostini, Anna Chiara; Galeazzi, Mauro; Gilio, Michele; Gionchetti, Paolo; Gisondi, Paolo; Lubrano, Ennio; Marchesoni, Antonio; Offidani, Annamaria; Orlando, Ambrogio; Pugliese, Daniela; Salvarani, Carlo; Scarpa, Raffaele; Vecchi, Maurizio; Girolomoni, Giampiero

2018-04-01

Immune-mediated inflammatory diseases (IMIDs) are chronic autoimmune conditions that share common pathophysiologic mechanisms. The optimal management of patients with IMIDs remains challenging because the coexistence of different conditions requires the intervention of several specialists. The aim of this study was to develop a series of statements defining overarching principles that guide the implementation of a multidisciplinary approach for the management of spondyloarthritis (SpA)-related IMIDs including SpA, psoriasis, psoriatic arthritis, Crohn's disease, ulcerative colitis and uveitis. A Delphi consensus-based approach was used to identify a core set of statements. The process included development of initial questions by a steering committee, an exhaustive search of the literature using complementary approaches to identify potential statements and two Delphi voting rounds for finalization of the statements. Consensus was achieved on the related nature of IMIDs, the existence of a high prevalence of multiple IMIDs in a single patient and the fact that a multidisciplinary approach can result in a more extensive evaluation and comprehensive approach to treatment. The goals of a multidisciplinary team should be to increase diagnosis of concomitant IMIDs, improve the decision-making process, and increase patient satisfaction and adherence. Early referral and diagnosis, early recognition of concomitant IMIDs and optimizing treatment to improve patient quality of life are some of the advantages of using multidisciplinary teams. To be effective, a multidisciplinary team should be equipped with the appropriate tools for diagnosis and follow-up, and at a minimum the multidisciplinary team should include a dermatologist, gastroenterologist and rheumatologist; providing psychologic support via a psychologist and involving an ophthalmologist, general practitioners and nurses in multidisciplinary care is also important. The present Delphi consensus identified a set of

Can measuring immunity to HIV during antiretroviral therapy (ART ...

African Journals Online (AJOL)

The vexing issue of whether the immune system can be reconstituted during HIV infection by supplying antiretroviral therapy (ART) has been a question asked about HIV-infected adults and children receiving therapy.1-9 Knowing that the immune system is sufficiently plastic in adults to show restoration of specific and ...

Special Issue: Book Reviews. Resources for Career Management, Counseling, Training and Development.

Science.gov (United States)

Horvath, Clara, Ed.; And Others

1995-01-01

This special issue includes reviews of 32 books on the following topics: management, human resources, and organizational development; career counseling, guidance, and assessment; job search; resumes; careers in specific fields; careers for special populations; career transitions; and finding balance. (SK)

Environmental and waste management issues, causes, characteristics, and cures

International Nuclear Information System (INIS)

Duffy, L.P.

1992-01-01

The department of Energy (DOE) views as one of its most challenging problems the minimization, management, and cleanup of waste materials generated from Departmental operations. The challenges for the DOE have striking similarities to the environmental restoration and waste management challenges associated with energy production and the mining and mineral processing industries. Their challenges relate to uranium mining and the resulting mill tailings; decontamination and decommissioning of facilities; processing of nuclear materials and production of weapons components. Add to this the challenge of environmental restoration solutions for waste disposal practices of the past. The fundamental goal of the DOE is to ensure that risks to human health and safety and to the environment posed by the department's past, present, and future operations are either eliminated to reduced to prescribed levels by the year 2019. To achieve this goal they must be able to assess environmental and health impacts resulting from the low concentrations of contaminants. This paper presents an overview of the causes, characteristics, and cures for these environmental restoration and waste management issues

Integrated systems for NGS data management and analysis: open issues and available solutions

Directory of Open Access Journals (Sweden)

Valerio eBianchi

2016-05-01

Full Text Available Next-generation sequencing (NGS technologies have deeply changed our understanding of cellular processes by delivering an astonishing amount of data at affordable prices; nowadays, many biology laboratories have already accumulated a large number of sequenced samples. However, managing and analyzing these data poses new challenges, which may easily be underestimated by research groups devoid of IT and quantitative skills. In this perspective, we identify five issues that should be carefully addressed by research groups approaching NGS technologies. In particular, the five key issues to be considered concern: 1 adopting a laboratory management system (LIMS and safeguard the resulting raw data structure in downstream analyses; 2 monitoring the flow of the data and standardizing input and output directories and file names, even when multiple analysis protocols are used on the same data; 3 ensuring complete traceability of the analysis performed; 4 enabling non-experienced users to run analyses through a graphical user interface (GUI acting as a front-end for the pipelines; 5 relying on standard metadata to annotate the datasets, and when possible using controlled vocabularies, ideally derived from biomedical ontologies. Finally, we discuss the currently available tools in the light of these issues, and we introduce HTS-flow, a new workflow management system (WMS conceived to address the concerns we raised. HTS-flow is able to retrieve information from a LIMS database, manages data analyses through a simple GUI, outputs data in standard locations and allows the complete traceability of datasets, accompanying metadata and analysis scripts.

Assessment and Management of Professionalism Issues in Pathology Residency Training

Directory of Open Access Journals (Sweden)

Ronald E. Domen MD

2015-07-01

Full Text Available Professionalism issues are common in residency training and can be very difficult to recognize and manage. Almost one-third of the milestones for pathology recently instituted by the Accreditation Council for Graduate Medical Education encompass aspects of professionalism. Program directors are often unsure of how and when to remediate residents for unprofessional behavior. We used a case-based educational approach in a workshop setting to assist program directors in the management of unprofessional behavior in residents. Eight case scenarios highlighting various aspects of unprofessional behavior by pathology residents were developed and presented in an open workshop forum at the annual pathology program director’s meeting. Prior to the workshop, 2 surveys were conducted: (1 to collect data on program directors’ experience with identifying, assessing, and managing unprofessional behavior in their residents and (2 to get feedback from workshop registrants on how they would manage each of the 8 case scenarios. A wide range of unprofessional behaviors have been observed by pathology program directors. Although there is occasionally general agreement on how to manage specific behaviors, there remains wide variation in how to manage many of the presented unprofessional behaviors. Remediation for unprofessional behavior in pathology residents remains a difficult and challenging process. Additional education and research in this area are warranted.

Core issues of a water resource management. A review of literature

International Nuclear Information System (INIS)

Chavarro Velandia, Andres

2011-01-01

Water becomes recently scarce in many developing countries. Colombia is one of these if it takes into account the warnings included in the last national water research. Therefore is urgent debate about which are the options to achieve a sustainable management of water. So, the objective of the present paper is to explore the core issues to be considered in order to discuss the problematic of the water management for Colombia. The paper is a review of literature from 5 date bases internationally recognized. From the review it found the management of water is more than the mere use of mechanisms but it implies consider topics like governance, solid knowledge about who and how use the water and then yet the options to manage it. In addition it found that market based perspectives tend to work isolated compare to the rest of alternatives which are multi-disciplinary and multi-dimensional. Finally, stand out the fact that the non-market management tools tends to be integrated management water models (it includes multiple sources, actors and different applications)

Cleaning up DOE's weapons sites: Issues of organization and management

International Nuclear Information System (INIS)

Morzinski, J.A.

1994-01-01

Many Department of Energy facilities across the United States are seriously contaminated with radioactive and other hazardous wastes. Decades of focus on weapons production and inadequate attention to long-term solutions for dealing with those wastes have resulted in tremendous problems. The Department of Energy recognizes the seriousness of those problems and is addressing them. In some cases existing management systems are being used to accomplish the new mission of environmental cleanup, and in other cases new systems have been created to help carry out that mission. Widespread criticism of those efforts to data are evidence that the management systems being used may not be appropriate for the job. In particular, it appears that some management systems aren't producing desired results because they are not well aligned with the people and tasks for whom they are intended, and these issues are discussed in this report

Issues in the management of low-level radioactive wastes

International Nuclear Information System (INIS)

Ashbrook, A.W.

1984-01-01

All industry finds itself today enmeshed in a morass of regulation, political apathy and public antagonism when it comes to hazardous industrial waste. Our industry is a world-class leader on all three fronts. There are no disposal facilities in Canada for radioactive wastes and the prognosis for the future is bleak. As the industry gets older, more and more facilities will be closed and require decommissioning. New facilities require plans for the long-term management of their wastes. Indeed, one major public issue with the nuclear industry is the fate of the wastes produced. In looking at the situation in which we find ourselves today with respect to the long-term management of naturally-occurring low-level radioactive wastes, one must wonder where we are going in the future, and whether indeed is an end in sight

Radiotherapy and immune checkpoint blockades: a snapshot in 2016

Energy Technology Data Exchange (ETDEWEB)

Koo, Tae Yool [Dept. of Radiation Oncology, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon (Korea, Republic of); Kim, In Ah [Dept. of Radiation Oncology, Seoul National University College of Medicine, Seoul (Korea, Republic of)

2016-12-15

Immune checkpoint blockades including monoclonal antibodies (mAbs) of cytotoxic T-lymphocyte antigen-4 (CTLA-4), programmed death-1 (PD-1), and programmed death-ligand 1 (PD-L1) have been emerged as a promising anticancer therapy. Several immune checkpoint blockades have been approved by US Food and Drug Administration (FDA), and have shown notable success in clinical trials for patients with advanced melanoma and non-small cell lung cancer. Radiotherapy is a promising combination partner of immune checkpoint blockades due to its potent pro-immune effect. This review will cover the current issue and the future perspectives for combined with radiotherapy and immune checkpoint blockades based upon the available preclinical and clinical data.

Introduction to radioactive waste management issues in Wisconsin

International Nuclear Information System (INIS)

Anon.

1977-01-01

This brief focused on wastes from commercial production of electricity and various industrial, medical and research applications of radioactive materials. Only traditionally solid wastes are dealt with. It was organized into five parts. Part I presented an introduction to radioactivity - what it is and the biological hazards associated with it. Federal regulation of the management of radioactive wastes was discussed in Part II. Existing state laws and bills currently before the Wisconsin Legislature were described in Part III. Part IV gave background information on specific areas of potential inquiry related to radioactive wastes in Wisconsin. Part V summarized the issues identified in the brief. 2 figures, 7 tables

Common Issues Seen in Paediatric Diabetes Clinics, Psychological Formulations, and Related Approaches to Management.

Science.gov (United States)

Deeb, Asma; Akle, Mariette; Al Ozairi, Abdulla; Cameron, Fergus

2018-01-01

Diabetes is a chronic disease and its management is associated with multiple challenges. This is particularly the case in children and adolescents. Factors that contribute to difficulties in managing diabetes in youth include psychological characteristics, family dynamics, and social behavior. The purpose of this article is to highlight some psychological issues in children and adolescents with diabetes. We aim to present selected case scenarios encountered by health professionals and to provide tips on strategies for managing psychological aspect of diabetes. We tackle the psychological issues related to diabetes under four main categories: maladaptive disorders, eating disorders, family psychopathology, and family dysfunction. Psychotherapy and psychoanalysis are useful modalities in diabetes management. The psychological intervention is aimed at supporting patients and families to reach a balance between a normal family routine and a good glycemic control. We demonstrate unique requirements in coordinating care for children and adolescents with diabetes and highlight the importance of encouraging a positive behavior. Managing diabetes in children and adolescents needs to be in the form of a collaborative work between health care professionals, children and adolescents, and their families. Caring, supportive family backed up by experienced multidisciplinary team is the best approach to prevent psychological difficulties.

EDF ageing management program of nuclear components: a safety and economical issue

International Nuclear Information System (INIS)

Faidy, C.

2005-01-01

Ageing management of Nuclear Power Plants is an essential issue for utilities, in term of safety and availability and corresponding economical consequences. Practically all nuclear countries have developed a systematic program to deal with ageing of components on their plants. This paper presents the ageing management program developed by EDF and that are compared with different other approaches in other countries (IAEA guidelines and GALL report). The paper presents a general overview of the programs, the major results, recommendations and conclusions. (author)

Immune Monitoring in Cancer Vaccine Clinical Trials: Critical Issues of Functional Flow Cytometry-Based Assays

Directory of Open Access Journals (Sweden)

Iole Macchia

2013-01-01

Full Text Available The development of immune monitoring assays is essential to determine the immune responses against tumor-specific antigens (TSAs and tumor-associated antigens (TAAs and their possible correlation with clinical outcome in cancer patients receiving immunotherapies. Despite the wide range of techniques used, to date these assays have not shown consistent results among clinical trials and failed to define surrogate markers of clinical efficacy to antitumor vaccines. Multiparameter flow cytometry- (FCM- based assays combining different phenotypic and functional markers have been developed in the past decade for informative and longitudinal analysis of polyfunctional T-cells. These technologies were designed to address the complexity and functional heterogeneity of cancer biology and cellular immunity and to define biomarkers predicting clinical response to anticancer treatment. So far, there is still a lack of standardization of some of these immunological tests. The aim of this review is to overview the latest technologies for immune monitoring and to highlight critical steps involved in some of the FCM-based cellular immune assays. In particular, our laboratory is focused on melanoma vaccine research and thus our main goal was the validation of a functional multiparameter test (FMT combining different functional and lineage markers to be applied in clinical trials involving patients with melanoma.

ROUTINE IMMUNIZATION IN INDIA: A PERSPECTIVE

Directory of Open Access Journals (Sweden)

G Taneja

2013-08-01

Full Text Available The Universal Immunization Programme is possibly the longest and one of the biggest public health intervention measures undertaken in India. To improve immunization coverage in the country various initiatives have been undertaken since the inception of the programme in 1985; key inputs being strengthening and expanding the cold chain system, establishing a network of outreach immunization sites, alternate vaccine delivery model, capacity building of health functionaries and medical officers and intensified polio control measures. Introduction of new and underutilized vaccines, drafting of the national vaccine policy, tracking of beneficiaries through the Maternal and Child Tracking system are some of the recent developments. However in spite of more than 25 years since inception the programme is still adversely impacted by challenges across key thematic areas of programme management, cold chain and vaccine management, recording and reporting and injection safety. To further strengthen and improve service delivery 2012-13 has been declared as the “Year of Intensification of Routine Immunization” with the objective of improving immunization coverage rates across poor performing districts and states so as to attain Global Immunization Vision and Strategy goals of 90% coverage at national and more than 80% coverage at district level. Key activities planned during the year include sustained advocacy at all levels, improved communication and social mobilization, robust and regular program reviews, comprehensive microplanning, strengthening cold chain and vaccine logistics system, special catch up rounds through immunization weeks, piloting the teeka express, improved surveillance systems, strengthened partnerships and operational research activities. The current review pertains to the existing scenario of Universal Immunization Program in the country with impetus on the existing challenges, progress achieved till date as a result of various

Immune epitope database analysis resource

DEFF Research Database (Denmark)

Kim, Yohan; Ponomarenko, Julia; Zhu, Zhanyang

2012-01-01

The immune epitope database analysis resource (IEDB-AR: http://tools.iedb.org) is a collection of tools for prediction and analysis of molecular targets of T- and B-cell immune responses (i.e. epitopes). Since its last publication in the NAR webserver issue in 2008, a new generation of peptide......, and the homology mapping tool was updated to enable mapping of discontinuous epitopes onto 3D structures. Furthermore, to serve a wider range of users, the number of ways in which IEDB-AR can be accessed has been expanded. Specifically, the predictive tools can be programmatically accessed using a web interface...

Multilevel Association Rule Mining for Bridge Resource Management Based on Immune Genetic Algorithm

Directory of Open Access Journals (Sweden)

Yang Ou

2014-01-01

Full Text Available This paper is concerned with the problem of multilevel association rule mining for bridge resource management (BRM which is announced by IMO in 2010. The goal of this paper is to mine the association rules among the items of BRM and the vessel accidents. However, due to the indirect data that can be collected, which seems useless for the analysis of the relationship between items of BIM and the accidents, the cross level association rules need to be studied, which builds the relation between the indirect data and items of BRM. In this paper, firstly, a cross level coding scheme for mining the multilevel association rules is proposed. Secondly, we execute the immune genetic algorithm with the coding scheme for analyzing BRM. Thirdly, based on the basic maritime investigation reports, some important association rules of the items of BRM are mined and studied. Finally, according to the results of the analysis, we provide the suggestions for the work of seafarer training, assessment, and management.

'I'm more sick than my doctors think': ethical issues in managing somatization in developing countries.

Science.gov (United States)

Chandra, Prabha S; Satyanarayana, Veena A

2013-02-01

Several ethical issues confront the healthcare professional who is managing somatization in developing countries where cost constraints, low literacy, poverty, poor nutrition and infections and inadequate access to healthcare are common. The paper discusses these in the context of the ethical principles of autonomy, beneficence, non-maleficence and justice. Some of the ethical issues in managing somatization include being influenced by patient distress rather than rational medical decision-making, inadequate attention to the cultural meaning of symptoms, psychologizing versus medicalizing, the ethics of nomenclature and labels, communicating ethically with patients, and managing them adequately given lack of evidence and training. An ethical approach to managing somatization in this context would include using an integrated and simultaneous medical and psychiatric approach. To ensure patient beneficence, the medical, psychological and social assessment should be undertaken side-by-side as much as possible and should be cost effective. Respecting patient autonomy by using adequate communication methods and the patient's cultural model of the illness as part of management is also integral to ethical practice. In the developing world, issues of equity are also an important ethical concern. When more serious illnesses are the health priority, functional syndromes may not get equal importance or resources.

Therapeutic potential of helminths in autoimmune diseases: helminth-derived immune-regulators and immune balance.

Science.gov (United States)

Wang, Meng; Wu, Linxiang; Weng, Rennan; Zheng, Weihong; Wu, Zhongdao; Lv, Zhiyue

2017-08-01

Helminths have accompanied human throughout history by releasing immune-evasion molecules that could counteract an aberrant immune response within the host. In the past decades, helminth infections are becoming less prevalent possibly due to the developed sanitation. Meanwhile, the incidence of autoimmune diseases is increasing, which cannot be exclusively explained by the changes of susceptibility genes. While the hygiene hypothesis casts light on the problem. The infections of helminths are believed to interact with and regulate human immunity with the byproduct of suppressing the autoimmune diseases. Thus, helminths are potential to treat or cure the autoimmune diseases. The therapeutic progresses and possible immune suppression mechanisms are illustrated in the review. The helminths that are studied most intensively include Heligmosomoides polygyrus, Hymenolepis diminuta, Schistosoma mansoni, Trichinella spiralis, and Trichuris suis. Special attentions are paid on the booming animal models and clinical trials that are to detect the efficiency of immune-modulating helminth-derived molecules on autoimmune diseases. These trials provide us with a prosperous clinical perspective, but the precise mechanism of the down-regulatory immune response remains to be clarified. More efforts are needed to be dedicated until these parasite-derived immune modulators could be used in clinic to treat or cure the autoimmune diseases under a standard management.

Market-Driven Solutions to Economic, Environmental, and Social Issues Related to Water Management in the Western USA

Directory of Open Access Journals (Sweden)

Jordan A. Clayton

2009-10-01

Full Text Available Water management issues continue to plague the western United States, including rapid population growth, degraded aquatic ecosystems, unfulfilled claims to American Indian users, the threat of global warming, an economic recession, and many other issues. This essay outlines some advantages of market-driven reforms to the management of water resources in the western USA. Historical and contemporary western water resource issues are examined from economic, environmental, and social viewpoints. In all such contexts, it is argued that regulated water markets provide flexible and just solutions to western water dilemmas, and reallocations may provide much-needed additional water supply.

Clarifying the Management Role in Dealing with Employees Personal Issues in the Lebanese Organizations

Directory of Open Access Journals (Sweden)

Abdallah Kamal Eldine

2017-06-01

Full Text Available The majority of workers have many occasional difficulties that sometimes become a problem affecting the worker’s performance. When this will repeatedly fail to meet expectations, a serious problem may become the main reason which contributes to the job decline. Therefore, a pattern of reduced performance indicates the need for a supervisory action from managers. Poor performance could be reflected under three main categories, such as employee availability, employee productivity, and employee conduct. The reasons and causes of this poor performance could be a personal issue related to the employee. Many types of personal problems are affecting the job performance in organizations, such as marital strife, financial difficulties and child care complication. More serious difficulties and the abuse of these problems-if not resolved-may cause unending issues at work. This problem is highly important especially that it can affect the job performance and the company income. Moreover, it can simply result in the failure of the employee to meet the performance standards, which kills productivity. The purpose of this qualitative exploratory phenomenological study is to clarify the management role in dealing with employees personal issues in the Lebanese organizations as perceived by the lived experience of managers. The research instrument which will be used is a face-to-face structured interview with six managers of the major functions in different Lebanese organizations. The sample type will be by convenience.

Management perspective of the Alloy 600 issue at Calvert Cliffs

International Nuclear Information System (INIS)

Anon.

1992-01-01

In response to the question posed in the agenda regarding this presentation, let it be known at the onset that the impact of the pressurizer nozzle primary water stress corrosion cracking (PWSCC) on Calvert Cliffs was gigantic. It reached all levels of the Company management, including the Board of Directors. The investigation and repair cost over $20 million without any consideration for replacement power or consequential lost work by those who were involved in the repairs to the pressurizer. It occupied the attention of management and was a major ingredient to most decision processes for about eight months. It caused organizational modifications, capital commitments, and major resource reallocation. It became the focal point around which much of the site work revolved for approximately 6 months (until the repair process was well in hand and other issues prevailed). I will try and describe the impact it had on management, the ingredients used to reach certain important decisions and the concerns that influenced the decisions

Halal Supply Chain Management Streamlined Practices: Issues and Challenges

Science.gov (United States)

Hijrah Abd Kadir, Muhammad; Zuraidah Raja Mohd Rasi, Raja; Omar, Siti Sarah; Manap, Zariq Imran Abdul

2016-11-01

The quickly developing worldwide halal in business sector has given a remarkable window of chance, which empowers Malaysia to the renowned halal centre in worldwide (known as Halal-hubs). Malaysia also has proactively taken a lead in halal activities, which is presently considered as the benchmark for a halal framework worldwide. Malaysia also set up the Halal Industry Development Corporation (HDC) which driving a wide range of halal activities since the demand of halal food has increased significantly which is very crucial for a Muslim in ensuring its authenticity and integrity. Even in parallel to this developments, many studies has been conducted because there are many issues still occurs in the food industry. The issue of consumer awareness and understanding the halal principles, mixing of halal and non- halal products, halal certification and logo compliance with Shariah law and lack of regulation and enforcement need the serious attention by all parties along the supply chain. The challenges occur mainly in the halal food segregation and halal traceability of the products. The unit of analysis in this study different halal stakeholders group which are JAKIM, Halal Development Centre (HDC), Raw Material Manufacturers, Retailers and Government Agencies. This paper attempt discusses the issues and challenges occurs in the halal supply chain and faced by the practitioners as well as the relevant parties involved in the industry especially for food products manufacturers. The study would like to give a basic information about the issues and challenges in the contribution of Halal Supply Chain Management (HSCM) as well as for the future studies.

Common Issues Seen in Paediatric Diabetes Clinics, Psychological Formulations, and Related Approaches to Management

Directory of Open Access Journals (Sweden)

Asma Deeb

2018-01-01

Full Text Available Diabetes is a chronic disease and its management is associated with multiple challenges. This is particularly the case in children and adolescents. Factors that contribute to difficulties in managing diabetes in youth include psychological characteristics, family dynamics, and social behavior. The purpose of this article is to highlight some psychological issues in children and adolescents with diabetes. We aim to present selected case scenarios encountered by health professionals and to provide tips on strategies for managing psychological aspect of diabetes. We tackle the psychological issues related to diabetes under four main categories: maladaptive disorders, eating disorders, family psychopathology, and family dysfunction. Psychotherapy and psychoanalysis are useful modalities in diabetes management. The psychological intervention is aimed at supporting patients and families to reach a balance between a normal family routine and a good glycemic control. We demonstrate unique requirements in coordinating care for children and adolescents with diabetes and highlight the importance of encouraging a positive behavior. Managing diabetes in children and adolescents needs to be in the form of a collaborative work between health care professionals, children and adolescents, and their families. Caring, supportive family backed up by experienced multidisciplinary team is the best approach to prevent psychological difficulties.

International conference on issues and trends in radioactive waste management. Contributed papers

International Nuclear Information System (INIS)

2002-01-01

This publication contains 78 contributed papers submitted on issues falling within the thematic scope of the Conference which were accepted by the Conference Programme Committee for consideration at the conference. The papers are grouped into the following chapters: control of discharges, environmental aspects; long-term storage; geological disposal; management of radioactive waste, including sealed sources; management of radioactive waste from past eras; regulatory infrastructure, decision making, stakeholders; retention of information, long-term control, standards; specific studies; and international co-operative efforts. Each of the papers was indexed separately

Doing Projects in a Foreign Language — Communications Management, Issues and Strategies

Science.gov (United States)

Xian, Deling

The Qinghai Salt Lake Industry Co. Ltd. (QSLIC) smelter project involves a Chinese state-owned client, a Canadian engineering company, their American technology partner, several Chinese design institutes and international vendors. Proper technical communication plays an important role during the development of a project in a foreign language and across cultures. Using the QSLIC project as an example, this paper presents the role of Communications Manager and personal qualifications required, as well as technical communications management, issues and strategies, lessons learnt while doing smelter projects in China and Chinese business culture and etiquette.

International conference on issues and trends in radioactive waste management. Contributed papers

Energy Technology Data Exchange (ETDEWEB)

NONE

2002-07-01

This publication contains 78 contributed papers submitted on issues falling within the thematic scope of the Conference which were accepted by the Conference Programme Committee for consideration at the conference. The papers are grouped into the following chapters: control of discharges, environmental aspects; long-term storage; geological disposal; management of radioactive waste, including sealed sources; management of radioactive waste from past eras; regulatory infrastructure, decision making, stakeholders; retention of information, long-term control, standards; specific studies; and international co-operative efforts. Each of the papers was indexed separately.

Management of municipal, hazardous and radioactive wastes: An environmental overview. Current issue paper 109

International Nuclear Information System (INIS)

Yeager, K.L.

1990-10-01

This paper attempts to provide the reader with essential information on the quantity and types of solid, hazardous and radioactive wastes being generated in the province and to introduce some of the existing and future management options being considered. As well, a number of possible issues are identified which may stimulate further interest in the future paths of waste management in Ontario. (author)

Management of municipal, hazardous and radioactive wastes: An environmental overview. Current issue paper 109

Energy Technology Data Exchange (ETDEWEB)

Yeager, K L

1990-10-01

This paper attempts to provide the reader with essential information on the quantity and types of solid, hazardous and radioactive wastes being generated in the province and to introduce some of the existing and future management options being considered. As well, a number of possible issues are identified which may stimulate further interest in the future paths of waste management in Ontario. (author).

Bartonella Endocarditis and Pauci-Immune Glomerulonephritis

Science.gov (United States)

Raybould, Jillian E.; Raybould, Alison L.; Morales, Megan K.; Zaheer, Misbah; Lipkowitz, Michael S.; Timpone, Joseph G.; Kumar, Princy N.

2016-01-01

Abstract Among culture-negative endocarditis in the United States, Bartonella species are the most common cause, with Bartonella henselae and Bartonella quintana comprising the majority of cases. Kidney manifestations, particularly glomerulonephritis, are common sequelae of infectious endocarditis, with nearly half of all Bartonella patients demonstrating renal involvement. Although a pauci-immune pattern is a frequent finding in infectious endocarditis–associated glomerulonephritis, it is rarely reported in Bartonella endocarditis. Anti–neutrophil cytoplasmic antibody (ANCA) positivity can be seen with many pathogens causing endocarditis and has been previously reported with Bartonella species. In addition, ANCA-associated vasculitis can also present with renal and cardiac involvement, including noninfectious valvular vegetations and pauci-immune glomerulonephritis. Given the overlap in their clinical presentation, it is difficult to differentiate between Bartonella endocarditis and ANCA-associated vasculitis but imperative to do so to guide management decisions. We present a case of ANCA-positive Bartonella endocarditis with associated pauci-immune glomerulonephritis that was successfully treated with medical management alone. PMID:27885316

Environmental impact assessment and socio political issues of nuclear waste management

International Nuclear Information System (INIS)

Harmaajaervi, I.; Tolsa, H.

1997-09-01

The study is a part of the Publicly Administrated Nuclear Waste Management Research Programme (JYT2) which was carried out in 1994-1996. The principal goal of the research programme has been to provide the authorities with information and research results relevant for the safety of nuclear waste management in order to support the various activities of the authorities. The main emphasis of the research programme focuses on the disposal of spent fuel. In addition to nuclear waste research in the field of natural sciences and technology, the research program- me has focused mostly on societal issues associated with nuclear waste disposal facilities and on the non-radiological environmental effects in the environs of the disposal site. Some of the local effects are already revealed in the research phase, before any final decisions are made as to the selection of the disposal site. The study has focused primarily on local and regional issues. The statutory requirement to conduct environ- mental impact assessment (EIA) chiefly concerns those who are responsible for waste management, but the authorities also need to acquire systematic information in the field to support developing requirements for the content and scope of EIA procedure and preparedness to check the assessments made. This is a report of the first parts of the study in 1994-1995. The report deals with the subject matter generally based on earlier studies in Finland and other countries. The results of the study will be reported later

Shared decision making in the management of children with newly diagnosed immune thrombocytopenia.

Science.gov (United States)

Beck, Carolyn E; Boydell, Katherine M; Stasiulis, Elaine; Blanchette, Victor S; Llewellyn-Thomas, Hilary; Birken, Catherine S; Breakey, Vicky R; Parkin, Patricia C

2014-10-01

This study aimed to examine the treatment decision-making process for children hospitalized with newly diagnosed immune thrombocytopenia (ITP). Using focus groups, we studied children with ITP, parents of children with ITP, and health care professionals, inquiring about participants' experience with decision support and decision making in newly diagnosed ITP. Data were examined using thematic analysis. Themes that emerged from children were feelings of "anxiety, fear, and confusion"; the need to "understand information"; and "treatment choice," the experience of which was age dependent. For parents, "anxiety, fear, and confusion" was a dominant theme; "treatment choice" revealed that participants felt directed toward intravenous immune globulin (IVIG) for initial treatment. For health care professionals, "comfort level" highlighted factors contributing to professionals' comfort with offering options; "assumptions" were made about parental desire for participation in shared decision making (SDM) and parental acceptance of treatment options; "providing information" was informative regarding modes of facilitating SDM; and "treatment choice" revealed a discrepancy between current practice (directed toward IVIG) and the ideal of SDM. At our center, families of children with newly diagnosed ITP are not experiencing SDM. Our findings support the implementation of SDM to facilitate patient-centered care for the management of pediatric ITP.

Essential 'ways-of-working' features of 'configuration management for new-build 2011' and 'issue-resolved replication'

International Nuclear Information System (INIS)

Schneider, B.

2011-01-01

The 'Ways-of-Working Foundation' of the Competencies most vital to 'New-Build' are provided. Examples are provided of local CM disasters and I-R.R success stories from else-where. [Configuration Management for New-Build 2011 - State-of-Art Specifications at Every Level - driven by Best-Available OpEx - based on SofA Expertise - subjected to Transparent, Independent Review]. It is the position of CMC2011 that weak CM is at the root of much 'less-than-adequate performance' (especially refurb programs - since ∼1986). For New-Build, the 'Foundation' of Configuration-Management is 'State-of-Art Specifications for All Systems, Equipment, Materials, and Processes' - supported by 'State-of-Art Service-Provider Expertise' - and Audit-able via 'Transparent, Third-Party, Issue-Review-and-Resolution Programs'. CM must be executed by the Architecture-Service-Providers - but it must be demanded by the Utility-Owners. [Issue-Resolved, Configuration-Managed, Replication - Rigorous, Configuration-Managed Replication for the Capture of the 85% that is Proven - plus - Parallel, Transparent, Separately-Managed, Contractually-Facilitated, Side-Stream Programs for the Identification and Resolution of the highly-troublesome 15% that remains Un-Resolved]. For New-Build in 2011, as well as for Refurb and Ops/Outage Support at any time, the last thing the Owner-Utilities want is innovation - or invention - or anything else for which substantial operating-experience and reliability-verification cannot be provided. I-R.R is discussed as - i) 'Rigorous Replication' and ii) 'Issue-Identification and Resolution'. What we refer to as 'Side-Stream, Independently-Driven, Issue-Identification and Resolution' is already practiced by utility 'SIR Teams' - i.e. - 'go-anywhere, do-anything, flying-squads' - for whom the watch-word is 'expect the un-anticipated'. Issue-Resolution must be provided as part of every project. It must be demanded (and contractually-facilitated) up-front by the Utility

Exploring Content Management Issues in Air Force On-Line Communities of Practice: A Multiple Case Study Approach

National Research Council Canada - National Science Library

Jaime

2004-01-01

.... Addressing existing or potential content management issues will help do so. This multiple-case study research observed and interviewed managers and members of eight active CoPs busted by AFMC/DRW...

Tourism and natural resource management: a general overview of research and issues.

Science.gov (United States)

Jeffrey D. Kline

2001-01-01

In recent years, growing awareness among tourism researchers of the relations between tourism and natural resource management has resulted in a substantial body of academic literature examining tourism issues under a relatively new set of tourism concepts. Seemingly new forms of tourism, such as nature-based tourism, ecotourism, and sustainable tourism, now are...

Do the Microbiota Influence Vaccines and Protective Immunity to Pathogens? Issues of Sovereignty, Federalism, and Points-Testing in the Prokaryotic and Eukaryotic Spaces of the Host-Microbial Superorganism.

Science.gov (United States)

Macpherson, Andrew J

2018-02-01

In contrast to live attenuated vaccines, which are designed to induce immunity through a time-limited bloom in systemic tissues, the microbiota is a persistent feature of body surfaces, especially the intestine. The immune responses to the microbiota are idiosyncratic depending on the niche intimacy of different taxa and generally adapt the host to avoid overgrowth and maintain mutualism rather than to eliminate the organisms of that taxon. Both the microbiota and the host have so much molecular cross talk controlling each other, that the prokaryotic and the eukaryotic spaces of the host-microbial superorganism are federal rather than sovereign. This molecular cross talk is vital for the immune system to develop its mature form. Nevertheless, the microbiota/host biomass spaces are rather well separated: The microbiota also limits colonization and penetration of pathogens through intense metabolic competition. Immune responses to those members of the microbiota mutually adapted to intimate association at mucosal surfaces have attractive potential durability, but for clinical use as persistent vehicles they would require personalization and engineered reversibility to manage the immune context and complications in individual human subjects. Copyright © 2018 Cold Spring Harbor Laboratory Press; all rights reserved.

The cloud security ecosystem technical, legal, business and management issues

CERN Document Server

Ko, Ryan

2015-01-01

Drawing upon the expertise of world-renowned researchers and experts, The Cloud Security Ecosystem comprehensively discusses a range of cloud security topics from multi-disciplinary and international perspectives, aligning technical security implementations with the most recent developments in business, legal, and international environments. The book holistically discusses key research and policy advances in cloud security - putting technical and management issues together with an in-depth treaties on a multi-disciplinary and international subject. The book features contributions from key tho

The burden and management of dyslipidemia: practical issues.

Science.gov (United States)

Schultz, Alyssa B; Chen, Chin-Yu; Burton, Wayne N; Edington, Dee W

2012-10-01

The objective of this study is to describe briefly the burden of dyslipidemia, and to discuss and present strategies for health professionals to improve dyslipidemia management, based on a review of selected literature focusing on interventions for dyslipidemia treatment adherence. Despite the availability of effective lifestyle and pharmaceutical therapies for dyslipidemias, they continue to present a significant economic burden in the United States. Adherence to evidence-based guidelines for the treatment of dyslipidemias is unsatisfactory. The reasons for medication nonadherence are complex and specific to each patient. The lack of progress in achieving optimal lipid targets is caused by many factors: patient (medication adherence, cost of medication, literacy), medication (adverse effects, complexity of regimen), provider (lack of adherence to evidence-based practice guidelines, poor communication), and the US healthcare system (being focused on acute care rather than prevention, lack of continuity of care, general lack of use of an electronic health record). Combined interventions that target each part of the system have been effective in improving treatment adherence and achieving lipid goals. Patients, providers, pharmacists, and employers all play a role in management of dyslipidemia. No single approach will solve the complex issue of improving dyslipidemia management. The required lifestyle changes are known and effective medications are available. The challenge is for all interested parties-including nurses, nurse practitioners, doctors, pharmacists, other health care professionals, employers, and health plans-to help patients achieve behavioral changes.

Through the Eyes of Higher Education Attorneys: How Department Chairs Are Navigating the Waters of Legal Issues and Risk Management

Science.gov (United States)

Hustoles, Carol L. J.

2012-01-01

Legal and risk management issues substantially impact the operations of colleges and universities, which face escalating compliance requirements in an increasingly litigious environment. Failing to assess legal liability issues and to constructively address them with risk management processes create vulnerability to claims and litigation,…

Contemporary management of locally advanced rectal cancer: Resolving issues, controversies and shifting paradigms.

Science.gov (United States)

Nacion, Aeris Jane D; Park, Youn Young; Kim, Nam Kyu

2018-02-01

Advancements in rectal cancer treatment have resulted in improvement only in locoregional control and have failed to address distant relapse, which is the predominant mode of treatment failure in rectal cancer. As the efficacy of conventional chemoradiotherapy (CRT) followed by total mesorectal excision (TME) reaches a plateau, the need for alternative strategies in locally advanced rectal cancer (LARC) has grown in relevance. Several novel strategies have been conceptualized to address this issue, including: 1) neoadjuvant induction and consolidation chemotherapy before CRT; 2) neoadjuvant chemotherapy alone to avoid the sequelae of radiation; and 3) nonoperative management for patients who achieved pathological or clinical complete response after CRT. This article explores the issues, recent advances and paradigm shifts in the management of LARC and emphasizes the need for a personalized treatment plan for each patient based on tumor stage, location, gene expression and quality of life.

Security issues at the Department of Energy and records management

International Nuclear Information System (INIS)

NUSBAUM, ANNA W.

2000-01-01

In order to discuss the connection between security issues within the Department of Energy and records management, the author covers a bit of security history and talks about what she calls ''the Amazing Project''. Initiated in late May 1999, it was to be a tri-laboratory (Lawrence Livermore National Laboratory of Livermore, California, Los Alamos National Laboratory of Los Alamos, New Mexico, and Sandia National Laboratories of Albuquerque, New Mexico, and Livermore, California) project. The team that formed was tasked to develop the best set of security solutions that still enabled weapon mission work to get done and the security solutions were to be the same set for everyone. The amazing project was called ''The Integrated Security Management Project'', or ''ISecM' for short. She'll describe why she thinks this project was so amazing and what it accomplished. There's a bit of sad news about the project, but then she'll move onto discuss what was learned at Sandia as a result of the project and what they're currently doing in records management

The role of radiotherapy for the induction of antitumor immune responses

International Nuclear Information System (INIS)

Multhoff, G.; Helmholtz-Zentrum Muenchen; Gaipl, U.S.; Niedermann, G.

2012-01-01

Effective radiotherapy is aimed to control the growth of the primary carcinoma and to induce a long-term specific antitumor immune response against the primary tumor, recurrence and metastases. The contribution covers the following issues: T cells and tumor specific immune responses, dendritic cells (DCs) start adaptive immune responses, NK (natural killer) cells for HLA independent tumor control, abscopal effects of radiotherapy, combination of radiotherapy and immune therapy, radiotherapy contribution to the induction of immunogenic cell death, combinability of radiotherapy and DC activation, combinability of radiotherapy and NK cell therapy. It turns out that the combination of radio-chemotherapy and immune therapy can change the microenvironment initiating antitumor immune reactions that inhibit the recurrence risk and the development of metastases.

Immune Signaling and Antimicrobial Peptide Expression in Lepidoptera

Directory of Open Access Journals (Sweden)

Heidi Goodrich-Blair

2013-07-01

Full Text Available Many lepidopteran insects are agricultural pests that affect stored grains, food and fiber crops. These insects have negative ecological and economic impacts since they lower crop yield, and pesticides are expensive and can have off-target effects on beneficial arthropods. A better understanding of lepidopteran immunity will aid in identifying new targets for the development of specific insect pest management compounds. A fundamental aspect of immunity, and therefore a logical target for control, is the induction of antimicrobial peptide (AMP expression. These peptides insert into and disrupt microbial membranes, thereby promoting pathogen clearance and insect survival. Pathways leading to AMP expression have been extensively studied in the dipteran Drosophila melanogaster. However, Diptera are an important group of pollinators and pest management strategies that target their immune systems is not recommended. Recent advances have facilitated investigation of lepidopteran immunity, revealing both conserved and derived characteristics. Although the general pathways leading to AMP expression are conserved, specific components of these pathways, such as recognition proteins have diverged. In this review we highlight how such comparative immunology could aid in developing pest management strategies that are specific to agricultural insect pests.

Management functions, issues, and configuration alternatives: TO support a transportation management configuration study: [Final report

International Nuclear Information System (INIS)

1987-01-01

The Office of Civilian Radioactive Waste Management (OCRWM) of the Department of Energy (DOE) is responsible for the safe transporation and disposal of spent nuclear fuel from utility-owned nuclear power generation reactors and high-level radioactive waste from both defense and civilian generators to long-term storage repositories. Given the volume, duration, and sensitivity of the operation, DOE is seeking not only the safest and best transportation system but also the most effective and resource-efficient management concept. Within the general guidelines of the Nuclear Waste Policy Act (NWPA) of 1982 calling for the fullest possible use of private industry contracts, this study examines the technical and administrative functions as well as the key issues to be addressed in the formation of a management structure. In order to stand alone as a comprehensive treatment of the total requirement, the material contained in many seperate and sometimes divergent DOE/OCRWM documents was evaluated and is compiled here. An attempt was made to succinctly define the nature of the problem, the objectives and scope of both the operating and management systems, and then to dissect the functions required in order to meet the objectives and operating functions are listed and described

Clipboard: Putting T cells to sleep: a new paradigm for immune ...

Indian Academy of Sciences (India)

2006-11-13

Nov 13, 2006 ... Home; Journals; Journal of Biosciences; Volume 31; Issue 5. Clipboard: Putting T cells to sleep: a new paradigm for immune evasion by persistent viruses. Shweta Dubey Shahid Jameel. Volume 31 Issue 5 December 2006 pp 497-501 ...

The Management of Multicampus Institutions: Some Conceptual Issues in Historical and Social Context.

Science.gov (United States)

Meek, Lynn

1992-01-01

Some ways of classifying multicampus universities in terms of administrative structure are examined and applied to Australian universities. Advantages and disadvantages of multicampus colleges are analyzed, and issues of management, governance, and authority are discussed. It is suggested that classification offers a point of departure for…

How reframing a water management issue across scales and levels impacts on perceptions of justice and injustice

Science.gov (United States)

Patrick, M. J.; Syme, G. J.; Horwitz, P.

2014-11-01

Social justice is a key outcome of water allocation, management and governance. It is commonly expressed in water policies and strategies in terms of achieving equitable distribution of water resources. In complex multi-level systems just and unjust outcomes can result from the same water allocation decision. In some cases a just outcome at one level may cause an injustice at another level for the same or a different set of stakeholders. The manner in which a water management issue is framed and reframed across different levels within a system influences stakeholder perceptions of whether a water allocation decision is just or unjust, which in turn influences the successful adoption and implementation of such a decision. This paper utilises a case study from the Murray-Darling Basin in Australia to illustrate how reframing a water management issue across multiple scales and levels can help understand stakeholders' perceptions of justice and injustice. In this case study two scales are explored, an institutional and an organisational scale; each comprising levels at the federal, basin, state and region. The water management issue of domestic and stock dams was tracked through the various scales and levels and illustrated how reframing an issue at different levels can influence the analysis of just or equitable outcomes. The case study highlights the need to treat justice in water allocation as an ever evolving problem of the behaviour of a social system rather than the meeting of static principles of what is 'right'. This points to the importance of being attentive to the dynamic and dialogical nature of justice when dealing with water allocation issues across scales and levels of water governance.

Immunity, feed, and husbandry in fish health management of cultured Epinephelus fuscoguttatus with reference to Epinephelus coioides

Directory of Open Access Journals (Sweden)

Catherine Cheng Yun Chieng

2018-03-01

Full Text Available Groupers are dispersed worldwide in the tropical and subtropical waters. They are prized in the live reef fish trade, making them candidates with high market value and consumer demand. In the Asian-Pacific region, the brown-marbled grouper (Epinephelus fuscoguttatus is widely adapted as an aquaculture species. However, health management remains a major concern in the stressful intensive culture process. The present review discusses techniques and current knowledge in the cultivation of E. fuscoguttatus towards healthy fish growth focusing on aspects of immunity, feed, and husbandry. Understanding how the fish immune system responds during infections provides insights into the intricate ways fish resist pathogens. This information is helpful when developing vaccination strategies or immunostimulant compounds to strengthen fish immunity. Feeds that are formulated according to the needs of the fish ensure optimal growth and using suitable alternative ingredients may lower production cost without compromising fish health. Good husbandry practices contribute to a favourable environment for the fish to grow, while interspecific hybridization may be a convenient approach to generate hardier species. Nevertheless, it has been noted that research in E. fuscoguttatus is relatively scarce in contrast to the closely-related orange-spotted grouper (E. coioides, which is used in the present article as a reference. Ultimately, the identified gaps in knowledge between the two species warrant species-specific research in E. fuscoguttatus to promote fish health and ensure continued success in aquaculture. Keywords: Epinephelus fuscoguttatus, Epinephelus coioides, Health, Immunity, Feed, Husbandry

Daylight Management in Mediterranean Cities: When Shortage Is Not the Issue

OpenAIRE

Judit Lopez-Besora; Glòria Serra-Coch; Helena Coch; Antonio Isalgue

2016-01-01

Natural resources such as daylight and sunlight are highly appreciated in countries with prevailing overcast skies. Taking advantage of this scarce resource contributes to saving energy on artificial lighting. In contrast to northern, southern European cities are distinguished by a large number of days with direct sunlight caused by a propitious climate condition. While it is a positive issue in terms of energy availability, the abundance of it can be counterproductive if management measures ...

A qualitative study exploring issues related to medication management in residential aged care facilities.

Science.gov (United States)

Ahmad Nizaruddin, Mariani; Omar, Marhanis-Salihah; Mhd-Ali, Adliah; Makmor-Bakry, Mohd

2017-01-01

Globally, the population of older people is on the rise. As families are burdened with the high cost of care for aging members, demand is increasing for medical care and nursing homes. Thus, medication management is crucial to ensure that residents in a care center benefit and assist the management of the care center in reducing the burden of health care. This study is aimed to qualitatively explore issues related to medication management in residential aged care facilities (RACFs). A total of 11 stakeholders comprising health care providers, administrators, caretakers and residents were recruited from a list of registered government, nongovernmental organization and private RACFs in Malaysia from September 2016 to April 2017. An exploratory qualitative study adhering to Consolidated Criteria for Reporting Qualitative Studies was conducted. In-depth interview was conducted with consent of all participants, and the interviews were audio recorded for later verbatim transcription. Observational analysis was also conducted in a noninterfering manner. Three themes, namely medication use process, personnel handling medications and culture, emerged in this study. Medication use process highlighted an unclaimed liability for residents' medication by the RACFs, whereas personnel handling medications were found to lack sufficient training in medication management. Culture of the organization did affect the medication safety and quality improvement. The empowerment of the residents in their medication management was limited. There were unclear roles and responsibility of who manages the medication in the nongovernment-funded RACFs, although they were well structured in the private nursing homes. There are important issues related to medication management in RACFs which require a need to establish policy and guidelines.

Monitoring Student Immunization, Screening, and Training Records for Clinical Compliance: An Innovative Use of the Institutional Learning Management System.

Science.gov (United States)

Elting, Julie Kientz

2017-12-13

Clinical compliance for nursing students is a complex process mandating them to meet facility employee occupational health requirements for immunization, screening, and training prior to patient contact. Nursing programs monitor clinical compliance with in-house management of student records, either paper or electronic, or by contracting with a vendor specializing in online record tracking. Regardless of method, the nursing program remains fully accountable for student preparation and bears the consequences of errors. This article describes how the institution's own learning management system can be used as an accurate, cost-neutral, user-friendly, and Federal Educational Rights Protection Act-compliant clinical compliance system.

Regulatory T cells and immunity to pathogens.

Science.gov (United States)

Rouse, Barry T; Suvas, Susmit

2007-09-01

Immune responses to pathogens are modulated by one or more types of cells that perform a regulatory function. Some cells with this function, such as CD4+ Foxp3+ natural regulatory T cells (nTreg), pre-exist prior to infections whereas others may be induced as a consequence of infection (adaptive Treg). With pathogens that have a complex pathogenesis, multiple types of regulatory cells could influence the outcome. One major property of Treg is to help minimize collateral tissue damage that can occur during immune reactions to a chronic infection. The consequence is less damage to the host but in such situations the pathogen is likely to establish persistence. In some cases, a fine balance is established between Treg responses, effector components of immunity and the pathogen. Treg responses to pathogens may also act to hamper the efficacy of immune control. This review discusses these issues as well as the likely mechanisms by which various pathogens can signal the participation of Treg during infection.

Potential contaminants in the food chain: identification, prevention and issue management.

Science.gov (United States)

Scanlan, Francis P

2007-01-01

Contaminants are a vast subject area of food safety and quality. They are generally divided into chemical, microbiological and physical classes and are present in our food chain from raw materials to finished products. They are the subject of international and national legislation that has widened to cover more and more contaminant classes and food categories. In addition, consumers have become increasingly aware of and alarmed by their risks, whether rightly or not. What is the food industry doing to ensure the safety and quality of the products we feed our children? This is a valid question which this article attempts to address from an industrial viewpoint. Chemical food safety is considered a complex field where the risk perception of consumers is often the highest. The effects of chronic or acute exposure to chemical carcinogens may cause disease conditions long after exposure that can be permanently debilitating or even fatal. It is also a moving target, as knowledge about the toxicity and occurrence data of new chemical contaminants continues to be generated. Their identification, prevention and management are challenges to the food industry as a whole. A reminder of the known chemical hazards in the food chain will be presented with an emphasis on the use of early warning to identify potential new contaminants. Early warning is also a means of prevention, anticipating food safety concerns before they become issues to manage. Current best management practices including Hazard Analysis and Critical Control Points relating to the supply chain of baby foods and infant formulae will be developed. Finally, key lessons from a case study on recent contamination issues in baby food products will be presented.

Transport modeling: An artificial immune system approach

Directory of Open Access Journals (Sweden)

Teodorović Dušan

2006-01-01

Full Text Available This paper describes an artificial immune system approach (AIS to modeling time-dependent (dynamic, real time transportation phenomenon characterized by uncertainty. The basic idea behind this research is to develop the Artificial Immune System, which generates a set of antibodies (decisions, control actions that altogether can successfully cover a wide range of potential situations. The proposed artificial immune system develops antibodies (the best control strategies for different antigens (different traffic "scenarios". This task is performed using some of the optimization or heuristics techniques. Then a set of antibodies is combined to create Artificial Immune System. The developed Artificial Immune transportation systems are able to generalize, adapt, and learn based on new knowledge and new information. Applications of the systems are considered for airline yield management, the stochastic vehicle routing, and real-time traffic control at the isolated intersection. The preliminary research results are very promising.

Producer responsibility for e-waste management: key issues for consideration - learning from the Swiss experience.

Science.gov (United States)

Khetriwal, Deepali Sinha; Kraeuchi, Philipp; Widmer, Rolf

2009-01-01

E-waste, a relatively recent addition to the waste stream in the form of discarded electronic and electric equipment, is getting increasing attention from policy makers as the quantity being generated is rising rapidly. One of the most promising policy options to address this issue is to extend the producers responsibility for their products beyond the point of sale, until end-of-product-life. This paper briefly introduces the concept of extended producer responsibility (EPR) and its applicability in the area of the end-of-life management of electronic and electrical equipment (EEE). It then examines the decade-long experience of Switzerland in using EPR to manage its e-waste, elaborating on the experience of the Swiss system in overcoming specific issues, and finally wrapping up with a synopsis of the lessons for policy makers. We consider each issue as an enquiry of questions confronting a policy maker and the choices that may present themselves. The five issues discussed are: (i) the challenges in getting an EPR based system started; (ii) securing financing to ensure a self-sustaining and smooth functioning system; (iii) organising a logistics network for the take back and collection of the e-waste; (iv) ensuring compliance of the various actors involved; and finally (v) reducing the threat of monopolistic practices.

Communication in crisis situations in the process of immunization.

Science.gov (United States)

Ravlija, Jelena; Vasilj, Ivan

2012-09-01

Immunization is one of the most effective medical interventions in the prevention of the disease and represents the easiest and most cost-effective investment in health. The strategy of controlling contagious diseases that can be prevented through immunization has a long tradition in B&H. Mandatory immunizations are administered against ten diseases. Although the development of new technologies, the efforts of the pharmaceutical industry, the development of new vaccines provides better vaccines in terms of greater safety and effectiveness it should be pointed out that no vaccine is "absolutely effective and safe", and it will not achieve the immune response in 100% vaccinated, also there are possible side effects and unexpected reactions that could occur. Vaccination is often a media issue because previously unnoticed local, isolated events-side effects and complications of vaccination are now accompanied by media attention as there are now numerous and fast communication channels (internet, e-mail, TV1 etc.) and media evolved from being less "controlled" to more "commercial". Doubt in benefit of vaccination is growing even among health professionals who are expected to provide up-to-date, understandable information, and issue information about immunization benefits and potential risks. It is therefore important for health professionals to be well informed, to be a good source of authoritative, scientific and reasonable advice, and to speak openly about the benefits and risks of vaccination so that consumers fully understand both possible outcomes of vaccination. This takes communication skills, particularly in crisis situations connected with vaccination. Health professionals are thus faced with a changing attitude toward importance of immunization in the social climate where risk is less tolerated than ever before.

Identity Management issues in Cloud Computing

OpenAIRE

Saini, Smita; Mann, Deep

2014-01-01

Cloud computing is providing a low cost on demand services to the users, omnipresent network,large storage capacity due to these features of cloud computing web applications are moving towards the cloud and due to this migration of the web application,cloud computing platform is raised many issues like privacy, security etc. Privacy issue are major concern for the cloud computing. Privacy is to preserve the sensitive information of the cloud consumer and the major issues to the privacy are un...

The role of innate immunity in the development of chronic rhinosinusitis and perspectives of its conservative management

Directory of Open Access Journals (Sweden)

V. I. Egorov

2016-01-01

Full Text Available Chronic rhinosinusitis (CRS is a heterogeneous, multifactorial disease of unknown etiology, with an underlying deficient immune response to infectious and other triggers, leading to their incomplete elimination and persistence of inflammation. Development of CRS is made possible by a deficient response of the innate immunity of nasal and paranasal sinus mucosa. The main factors of non-specific defense system of nasal and paranasal mucosa are the function of cell junctions between epithelial cells, mucociliary clearance, pattern recognition receptors (PRRs, antigen presenting cells, and phagocytosis. The multirowed ciliate epithelium of nasal and paranasal sinus mucosa is covered by a thick layer of mucus containing more than 200 proteins. Changes in the qualitative composition of the nasal mucus in CRS manifests in overexpression of the main mucins MUC5AC and MUC5B and decreased synthesis of lactoferrin and lyzocin. Ciliary dyskinesia or abnormalities in their microstructure lead to decreased efficacy of mucociliary clearance. Diminished expression of proteins of tight junctions (TJ ZO-1 and occluding results in decreased density of intercellular contacts and increased permeability of epithelial barrier. In addition, CRS is characterized by deficient Tolllike receptors (TLR 9, 2 and 4, as well as increased counts of M2 macrophages in the mucosa. This results in suppressed phagocytosis and antimicrobial mucosal defense. Lower levels of STAT3 protein causes an imbalanced reaction of innate and adaptive immune response and disordered reparation processes. With abnormal functioning of all the above mentioned mechanisms, no immune elimination of infectious agents can take place, with increased susceptibility to viral and bacterial infections of the upper respiratory tract. This opens the door to development of CRS, including that with polyps. Investigation of the innate immunity factors would allow for predicting of inflammation in a given patient

A qualitative study exploring issues related to medication management in residential aged care facilities

Directory of Open Access Journals (Sweden)

Ahmad Nizaruddin M

2017-11-01

Full Text Available Mariani Ahmad Nizaruddin, Marhanis-Salihah Omar, Adliah Mhd-Ali, Mohd Makmor-Bakry Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia Background: Globally, the population of older people is on the rise. As families are burdened with the high cost of care for aging members, demand is increasing for medical care and nursing homes. Thus, medication management is crucial to ensure that residents in a care center benefit and assist the management of the care center in reducing the burden of health care. This study is aimed to qualitatively explore issues related to medication management in residential aged care facilities (RACFs.Participants and methods: A total of 11 stakeholders comprising health care providers, administrators, caretakers and residents were recruited from a list of registered government, nongovernmental organization and private RACFs in Malaysia from September 2016 to April 2017. An exploratory qualitative study adhering to Consolidated Criteria for Reporting Qualitative Studies was conducted. In-depth interview was conducted with consent of all participants, and the interviews were audio recorded for later verbatim transcription. Observational analysis was also conducted in a noninterfering manner.Results and discussion: Three themes, namely medication use process, personnel handling medications and culture, emerged in this study. Medication use process highlighted an unclaimed liability for residents’ medication by the RACFs, whereas personnel handling medications were found to lack sufficient training in medication management. Culture of the organization did affect the medication safety and quality improvement. The empowerment of the residents in their medication management was limited. There were unclear roles and responsibility of who manages the medication in the nongovernment-funded RACFs, although they were well structured in the private nursing homes.Conclusion: There are important issues

Extracellular cell stress (heat shock) proteins-immune responses and disease: an overview.

Science.gov (United States)

Pockley, A Graham; Henderson, Brian

2018-01-19

Extracellular cell stress proteins are highly conserved phylogenetically and have been shown to act as powerful signalling agonists and receptors for selected ligands in several different settings. They also act as immunostimulatory 'danger signals' for the innate and adaptive immune systems. Other studies have shown that cell stress proteins and the induction of immune reactivity to self-cell stress proteins can attenuate disease processes. Some proteins (e.g. Hsp60, Hsp70, gp96) exhibit both inflammatory and anti-inflammatory properties, depending on the context in which they encounter responding immune cells. The burgeoning literature reporting the presence of stress proteins in a range of biological fluids in healthy individuals/non-diseased settings, the association of extracellular stress protein levels with a plethora of clinical and pathological conditions and the selective expression of a membrane form of Hsp70 on cancer cells now supports the concept that extracellular cell stress proteins are involved in maintaining/regulating organismal homeostasis and in disease processes and phenotype. Cell stress proteins, therefore, form a biologically complex extracellular cell stress protein network having diverse biological, homeostatic and immunomodulatory properties, the understanding of which offers exciting opportunities for delivering novel approaches to predict, identify, diagnose, manage and treat disease.This article is part of the theme issue 'Heat shock proteins as modulators and therapeutic targets of chronic disease: an integrated perspective'. © 2017 The Author(s).

Codes of practice and related issues in biomedical waste management

Energy Technology Data Exchange (ETDEWEB)

Moy, D.; Watt, C. [Griffith Univ. (Australia)

1996-12-31

This paper outlines the development of a National Code of Practice for biomedical waste management in Australia. The 10 key areas addressed by the code are industry mission statement; uniform terms and definitions; community relations - public perceptions and right to know; generation, source separation, and handling; storage requirements; transportation; treatment and disposal; disposal of solid and liquid residues and air emissions; occupational health and safety; staff awareness and education. A comparison with other industry codes in Australia is made. A list of outstanding issues is also provided; these include the development of standard containers, treatment effectiveness, and reusable sharps containers.

Embedded generation and network management issues

Energy Technology Data Exchange (ETDEWEB)

NONE

2000-07-01

This report focuses on the characteristics of power generators that are important to accommodation in a distribution system. Part 1 examines the differences between transmission and distribution systems, and issues such as randomness, diversity, predictability, and controllability associated with accommodation in a distribution system. Part 2 concentrates on technical and operational issues relating to embedded generation, and the possible impact of the New Electricity Trading Arrangements. Commercial issues, contractual relationships for network charging and provision of services, and possible ways forward are examined in the last three parts of the report.

Interprofessional Collaboration with Immune Checkpoint Inhibitor Therapy: the Roles of Gastroenterology, Endocrinology and Neurology.

Science.gov (United States)

Seery, Virginia

2017-11-01

To discuss immune checkpoint inhibitor therapy and identify opportunities for interprofessional collaboration in the management of toxicities in the areas of gastroenterology, endocrinology, and neurology. Published research and education articles in oncology, nursing, and various specialties. The use of immune checkpoint inhibitors is expanding; timely management of toxicity is critical for positive patient outcomes. There are many opportunities for interprofessional collaboration in the diagnosis and treatment of immune-related adverse events. Nurses play key roles in recognizing immune-related adverse events, providing patient education, and helping to facilitate interprofessional collaboration. Copyright © 2017 Elsevier Inc. All rights reserved.

Innate Immune Responses in Leprosy

Science.gov (United States)

Pinheiro, Roberta Olmo; Schmitz, Veronica; Silva, Bruno Jorge de Andrade; Dias, André Alves; de Souza, Beatriz Junqueira; de Mattos Barbosa, Mayara Garcia; de Almeida Esquenazi, Danuza; Pessolani, Maria Cristina Vidal; Sarno, Euzenir Nunes

2018-01-01

Leprosy is an infectious disease that may present different clinical forms depending on host immune response to Mycobacterium leprae. Several studies have clarified the role of various T cell populations in leprosy; however, recent evidences suggest that local innate immune mechanisms are key determinants in driving the disease to its different clinical manifestations. Leprosy is an ideal model to study the immunoregulatory role of innate immune molecules and its interaction with nervous system, which can affect homeostasis and contribute to the development of inflammatory episodes during the course of the disease. Macrophages, dendritic cells, neutrophils, and keratinocytes are the major cell populations studied and the comprehension of the complex networking created by cytokine release, lipid and iron metabolism, as well as antimicrobial effector pathways might provide data that will help in the development of new strategies for leprosy management. PMID:29643852

Resolving legal issues in the transfer of technologies in environmental restoration and waste management

International Nuclear Information System (INIS)

Katz, J.; Richards, F. III; Underwood, J.P.

1994-01-01

In reforming its contracting and procurement processes, the Department of Energy (DOE) should also make reforms to facilitate the transfer and commercialization of environmental restoration and waste management technologies between DOE laboratories and the private sector. These reforms would address the three related legal issues of patents, conflict of interest, and liability. This paper discusses each issue and considers possible solutions to them. These solutions include contractual clauses to specifically address the needs of all involved parties, improved definition of development and implementation rights, and increased protections for contractors. If DOE, or the Federal Government more generally, successfully resolves these issues and makes the appropriate changes to the DOE procurement system, transfer and commercialization will more efficiently, effectively, and easily occur

Trade issues and area-wide pest management

International Nuclear Information System (INIS)

Griffin, Robert L.

2000-01-01

. The evidence indicates that this shift will bring significant benefits in increased production and trade, as well as offering more sustainable and environmentally acceptable pest management options. There is also the concern that as tariffs and other barriers are removed, countries may impose measures under the guise of protection in order to secure market or other unfair advantages. It is the nature of quarantine to follow the old adage, 'an ounce of prevention is better than a pound of cure', i.e., it is comparatively cheaper and easier to prevent the entry of pests with strongly restrictive measures than it is to deal with the result of pest introduction. But while a certain degree of care is clearly justified, unreasonably conservative policies are seen to unnecessarily restrict trade. The question revolves around the issue of justification. As globalisation and the liberalisation of trade have matured, and international trade in agricultural products has grown in importance, it has become necessary for 'free trade' and 'fair trade' to evolve still further to embrace the concept of 'safe trade'. That is to say, disciplines are necessary to ensure that protective measures are used to the extent justified by legitimate concerns, but not as unjustified barriers to trade. This brings the discussion to the early part of the 1990s and the last round of multilateral trade negotiations under the General Agreement on Tariffs and Trade (GATT) - the Uruguay Round, and the agreements therein related to agriculture. Emerging from these negotiations was the Agreement on the Application of Sanitary and Phytosanitary Measures (the SPS Agreement) which dealt specifically with the issue of measures to protect plant, animal and human health and life

International Production and Global Logistics Operations : Management Issues in Global Logistics with Offshored Production Systems

OpenAIRE

Korrmann, Franziska

2011-01-01

This paper is directed at discussing some of the management issues, problems and solutions of logistics in the context of offshored productive activities The introduction includes a discussion of the logistics topics and an introduction of the economic logic of offshoring. The main part analyses the logistics topics with regard to the internationally fragmented production. The topics of logistics include: Information flow and integration, transportation, inventory management, warehousing and ...

Influence of bedding type on mucosal immune responses.

Science.gov (United States)

Sanford, Amy N; Clark, Stephanie E; Talham, Gwen; Sidelsky, Michael G; Coffin, Susan E

2002-10-01

The mucosal immune system interacts with the external environment. In the study reported here, we found that bedding materials can influence the intestinal immune responses of mice. We observed that mice housed on wood, compared with cotton bedding, had increased numbers of Peyer's patches (PP) visible under a dissecting microscope. In addition, culture of lymphoid organs revealed increased production of total and virus-specific IgA by PP and mesenteric lymph node (MLN) lymphocytes from mice housed on wood, compared with cotton bedding. However, bedding type did not influence serum virus-specific antibody responses. These observations indicate that bedding type influences the intestinal immune system and suggest that this issue should be considered by mucosal immunologists and personnel at animal care facilities.

Incorporating immunizations into routine obstetric care to facilitate Health Care Practitioners in implementing maternal immunization recommendations.

Science.gov (United States)

Webb, Heather; Street, Jackie; Marshall, Helen

2014-01-01

Immunization against pertussis, influenza, and rubella reduces morbidity and mortality in pregnant women and their offspring. Health care professionals (HCPs) caring for women perinatally are uniquely placed to reduce maternal vaccine preventable diseases (VPDs). Despite guidelines recommending immunization during the perinatal period, maternal vaccine uptake remains low. This qualitative study explored the role of obstetricians, general practitioners, and midwives in maternal vaccine uptake. Semi-structured interviews (n = 15) were conducted with perinatal HCPs at a tertiary maternity hospital in South Australia. HCPs were asked to reflect on their knowledge, beliefs, and practice relating to immunization advice and vaccine provision. Interviews were transcribed and coded using thematic analysis. Data collection and analysis was an iterative process, with collection ceasing with theoretical saturation. Participants unanimously supported maternal vaccination as an effective way of reducing risk of disease in this vulnerable population, however only rubella immunity detection and immunization is embedded in routine care. Among these professionals, delegation of responsibility for maternal immunization was unclear and knowledge about maternal immunization was variable. Influenza and pertussis vaccine prevention measures were not included in standard pregnancy record documentation, information provision to patients was "ad hoc" and vaccinations not offered on-site. The key finding was that the incorporation of maternal vaccinations into standard care through a structured process is an important facilitator for immunization uptake. Incorporating vaccine preventable disease management measures into routine obstetric care including incorporation into the Pregnancy Record would facilitate HCPs in implementing recommendations. Rubella prevention provides a useful 'template' for other vaccines.

Managing heat and immune stress in athletes with evidence-based strategies.

Science.gov (United States)

Pyne, David B; Guy, Joshua H; Edwards, Andrew M

2014-09-01

Heat and immune stress can affect athletes in a wide range of sports and environmental conditions. The classical thermoregulatory model of heat stress has been well characterized, as has a wide range of practical strategies largely centered on cooling and heat-acclimation training. In the last decade evidence has emerged of an inflammatory pathway that can also contribute to heat stress. Studies are now addressing the complex and dynamic interplay between hyperthermia, the coagulation cascade, and a systemic inflammatory response occurring after transient damage to the gastrointestinal tract. Damage to the intestinal mucosal membrane increases permeability, resulting in leakage of endotoxins into the circulation. Practical strategies that target both thermoregulatory and inflammatory causes of heat stress include precooling; short-term heat-acclimation training; nutritional countermeasures including hydration, energy replacement, and probiotic supplementation; pacing strategies during events; and postevent cooling measures. Cooperation between international, national, and local sporting organizations is required to ensure that heat-management policies and strategies are implemented effectively to promote athletes' well-being and performance.

How supportive supervision influences immunization session site practices: a quasi-experimental study in Odisha, India.

Science.gov (United States)

Panda, Bhuputra; Pati, Sanghamitra; Nallala, Srinivas; Chauhan, Abhimanyu S; Anasuya, Anita; Som, Meena; Zodpey, Sanjay

2015-01-01

Routine immunization (RI) is a key child survival intervention. Ensuring acceptable standards of RI service delivery is critical for optimal outcomes. Accumulated evidences suggest that 'supportive supervision' improves the quality of health care services in general. During 2009-2010, the Government of Odisha and UNICEF jointly piloted this strategy in four districts to improve RI program outcomes. The present study aims to assess the effect of this strategy on improvement of skills and practices at immunization session sites. A quasi-experimental 'post-test only' study design was adopted to compare the opinion and practices of frontline health workers and their supervisors in four intervention districts (IDs) with two control districts (CDs). Altogether, we interviewed 111 supervisor-supervisee (health worker) pairs using semi-structured interview schedules and case vignettes. We also directly observed health workers' practices during immunization sessions at 111 sites. Data were analyzed with SPSS version 16.0. The mean knowledge score of supervisors in CDs was significantly higher than in intervention groups. Variegated responses were obtained on case vignettes. The control group performed better in solving certain hypothetically asked problems, whereas the intervention group scored better in others. Health workers in IDs gave a lower rating to their respective supervisors' knowledge, skill, and frequency of supervision. Logistics and vaccine availability were better in CDs. Notwithstanding other limitations, supportive supervision may not have independent effects on improving the quality of immunization services. Addressing systemic issues, such as the availability of essential logistics, supply chain management, timely indenting, and financial resources, could complement the supportive supervision strategy in improving immunization service delivery.

Issues in Canadian LLRW management

International Nuclear Information System (INIS)

Charlesworth, D.H.

1988-01-01

Some of the issues which are of concern in Canada are similar to those being discussed in the US because Canadian low-level radioactive waste (LLRW) production is similar in quantity and characteristics to that which will be handled by some state compacts. This paper gives a Canadian viewpoint of: the choice between interim storage and permanent disposal; the importance of considering inadvertent intrusion; the role of waste categorization and stability; and the concerns in assessing disposal performance. The discussion is related to Atomic Energy of Canada Limited's LLRW disposal program, and its approach to resolving these issues

Managing ethical issues in patient care and the need for clinical ethics support.

Science.gov (United States)

Doran, Evan; Fleming, Jennifer; Jordens, Christopher; Stewart, Cameron L; Letts, Julie; Kerridge, Ian H

2015-02-01

To investigate the range, frequency and management of ethical issues encountered by clinicians working in hospitals in New South Wales (NSW), Australia. A cross-sectional survey was conducted of a convenience sample of 104 medical, nursing and allied health professionals in two NSW hospitals. Some respondents did not provide data for some questions, therefore the denominator is less than 105 for some items. Sixty-two (62/104; 60%) respondents reported occasionally to often having ethical concerns. Forty-six (46/105; 44%) reported often to occasionally having legal concerns. The three most common responses to concerns were: talking to colleagues (96/105; 91%); raising the issue in a group forum (68/105; 65%); and consulting a relevant guideline (64/105; 61%). Most respondents were highly (65/99; 66%) or moderately (33/99; 33%) satisfied with the ethical environment of the hospital. Twenty-two (22/98; 22%) were highly satisfied with the ethical environment of their department and 74 (74/98; 76%) were moderately satisfied. Most (72/105; 69%) respondents indicated that additional support in dealing with ethical issues would be helpful. Clinicians reported frequently experiencing ethical and legal uncertainty and concern. They usually managed this by talking with colleagues. Although this approach was considered adequate, and the ethics of their hospital was reported to be satisfactory, most respondents indicated that additional assistance with ethical and legal concerns would be helpful. Clinical ethics support should be a priority of public hospitals in NSW and elsewhere in Australia.

Introduction to the special issue on "critical reflections on management and organizations: A postcolonial perspective"

OpenAIRE

Banerjee, S. B.; Prasad, A.

2008-01-01

Purpose - The purpose of this paper is to present a short note on postcolonialism as a field of critical inquiry in the business management field, and enable the guest editors to introduce the contents of a special issue entitled "Critical reflections on management and organization: a postcolonial perspective". \\ud \\ud Design/methodology/approach - The paper states that postcolonial theory seeks to critique and analyze the complex and multifaceted dynamics of modern Western colonialism and to...

Cultural dimensions in population related issues in Nigeria ...

African Journals Online (AJOL)

... population policy implementation strategies and implications for planning. Cultural practices, norms, values, beliefs and religion negatively influence procreation, population control measures, immunization, child survival transmission, management, child survival transmission, management and care of HIV and AIDS.

Immunity to intestinal pathogens: lessons learned from Salmonella

Science.gov (United States)

McSorley, Stephen J.

2014-01-01

Summary Salmonella are a common source of food or water-borne infection and cause a wide range of clinical disease in human and animal hosts. Salmonella are relatively easy to culture and manipulate in a laboratory setting, and the infection of laboratory animals induces robust innate and adaptive immune responses. Thus, immunologists have frequently turned to Salmonella infection models to expand understanding of immunity to intestinal pathogens. In this review, I summarize current knowledge of innate and adaptive immunity to Salmonella and highlight features of this response that have emerged from recent studies. These include the heterogeneity of the antigen-specific T-cell response to intestinal infection, the prominence of microbial mechanisms to impede T and B-cell responses, and the contribution of non-cognate pathways for elicitation of T-cell effector functions. Together, these different issues challenge an overly simplistic view of host-pathogen interaction during mucosal infection but also allow deeper insight into the real-world dynamic of protective immunity to intestinal pathogens. PMID:24942689

Too hot to handle. Social and policy issues in the management of radioactive wastes

International Nuclear Information System (INIS)

Walker, C.A.; Gould, L.C.; Woodhouse, E.J.

1983-01-01

Information about the management of radioactive wastes is provided in this book. Specifically, the book attempts to supply information to further the understanding of the history of radioactive waste management in this country and the role of nuclear energy in the future of the US; the science and technology of the processes that produce radioactive wastes and of the methods proposed for managing them; the biological effects of radiation; the public attitudes about nuclear power; the nature of risks resulting from technological developments and ways of managing them; and the political institutions and processes that govern radioactive waste management. The authors have attempted to present an objective view of nuclear waste management taking a stand neither for nor against nuclear power but placing special emphasis on radioactive waste management rather than nuclear power, because they feel that the latter aspect of the subject has received much more extensive coverage elsewhere. The contents of the book are divided into 7 chapters entitled: The Radioactive Waste Management Problem, Science and Technology of the Sources and Management of Radioactive Wastes, Nuclear Waste Management and Risks to Human Health, Public Attitudes toward Radioactive Wastes, How Safe Is Safe Enough; Determinants of Perceived and Acceptable Risk, The Politics of Nuclear Waste Management, and Value Issues in Radioactive Waste Management

Space Station Engineering Design Issues

Science.gov (United States)

Mcruer, Duane T.; Boehm, Barry W.; Debra, Daniel B.; Green, C. Cordell; Henry, Richard C.; Maycock, Paul D.; Mcelroy, John H.; Pierce, Chester M.; Stafford, Thomas P.; Young, Laurence R.

1989-01-01

Space Station Freedom topics addressed include: general design issues; issues related to utilization and operations; issues related to systems requirements and design; and management issues relevant to design.

Role of MicroRNAs in Obesity-Induced Metabolic Disorder and Immune Response.

Science.gov (United States)

Zhong, Hong; Ma, Minjuan; Liang, Tingming; Guo, Li

2018-01-01

In all living organisms, metabolic homeostasis and the immune system are the most fundamental requirements for survival. Recently, obesity has become a global public health issue, which is the cardinal risk factor for metabolic disorder. Many diseases emanating from obesity-induced metabolic dysfunction are responsible for the activated immune system, including innate and adaptive responses. Of note, inflammation is the manifest accountant signal. Deeply studied microRNAs (miRNAs) have participated in many pathways involved in metabolism and immune responses to protect cells from multiple harmful stimulants, and they play an important role in determining the progress through targeting different inflammatory pathways. Thus, immune response and metabolic regulation are highly integrated with miRNAs. Collectively, miRNAs are the new targets for therapy in immune dysfunction.

Managing information and knowledge within maternity services: Privacy and consent issues.

Science.gov (United States)

Baskaran, Vikraman; Davis, Kim; Bali, Rajeev K; Naguib, Raouf N G; Wickramasinghe, Nilmini

2013-09-01

Electronic Patient Records have improved vastly the quality and efficiency of care delivered. However, the formation of single demographic database and the ease of electronic information sharing give rise to many concerns including issues of consent, by whom and how data are accessed and used. This paper examines the organizational and socio-technical issues related to privacy, confidentiality and security when employing electronic records within a maternity service hospital in England. A preliminary questionnaire was administered (n  =  52), in total, 24 responses were received. Sixteen responses were from personnel in the information technology department, 5 from health information department and 3 from midwifery managers. This was followed by a semi-structured interview with representatives from the clinical and technological side. A number of issues related to information governance (IG) have been identified, especially breaches on sharing personal information without consent from the patients have been identified as one immediate challenge that needs to be fixed. There is an immediate need for more robust, realistic, built-in accountability both locally and nationally on data sharing. A culture of ownership and strict adherence to IG principles is paramount. Focused training in the area of data, information and knowledge sharing will bring in a balance of legitimate usage against the individual's rights to confidentiality and privacy.

Environmental issues and management strategies for waste electronic and electrical equipment.

Science.gov (United States)

Townsend, Timothy G

2011-06-01

Issues surrounding the impact and management of discarded or waste electronic and electrical equipment (WEEE) have received increasing attention in recent years. This attention stems from the growing quantity and diversity of electronic and electrical equipment (EEE) used by modern society, the increasingly rapid turnover of EEE with the accompanying burden on the waste stream, and the occurrence of toxic chemicals in many EEE components that can pose a risk to human and environmental health if improperly managed. In addition, public awareness of the WEEE or "e-waste" dilemma has grown in light of popular press features on events such as the transition to digital television and the exportation of WEEE from the United States and other developed countries to Africa, China, and India, where WEEE has often not been managed in a safe manner (e.g., processed with proper safety precautions, disposed of in a sanitary landfill, combusted with proper air quality procedures). This paper critically reviews current published information on the subject of WEEE. The definition, magnitude, and characteristics of this waste stream are summarized, including a detailed review of the chemicals of concern associated with different components and how this has changed and continues to evolve over time. Current and evolving management practices are described (e.g., reuse, recycling, incineration, landfilling). This review discusses the role of regulation and policies developed by governments, institutions, and product manufacturers and how these initiatives are shaping current and future management practices.

The role of immune mechanisms in Tourette syndrome.

Science.gov (United States)

Martino, Davide; Zis, Panagiotis; Buttiglione, Maura

2015-08-18

Tourette syndrome (TS) is a childhood-onset tic disorder associated with abnormal development of brain networks involved in the sensory and motor processing. An involvement of immune mechanisms in its pathophysiology has been proposed. Animal models based on active immunization with bacterial or viral mimics, direct injection of cytokines or patients' serum anti-neuronal antibodies, and transgenic approaches replicated stereotyped behaviors observed in human TS. A crucial role of microglia in the neural-immune crosstalk within TS and related disorders has been proposed by animal models and confirmed by recent post mortem studies. With analogy to autism, genetic and early life environmental factors could foster the involvement of immune mechanisms to the abnormal developmental trajectories postulated in TS, as well as lead to systemic immune dysregulation in this condition. Clinical studies demonstrate an association between TS and immune responses to pathogens like group A Streptococcus (GAS), although their role as risk-modifiers is still undefined. Overactivity of immune responses at a systemic level is suggested by clinical studies exploring cytokine and immunoglobulin levels, immune cell subpopulations, and gene expression profiling of peripheral lymphocytes. The involvement of autoantibodies, on the other hand, remains uncertain and warrants more work using live cell-based approaches. Overall, a body of evidence supports the hypothesis that disease mechanisms in TS, like other neurodevelopmental illnesses (e.g. autism), may involve dysfunctional neural-immune cross-talk, ultimately leading to altered maturation of brain pathways controlling different behavioral domains and, possibly, differences in organising immune and stress responses. This article is part of a Special Issue entitled SI: Neuroimmunology in Health And Disease. Copyright © 2014 Elsevier B.V. All rights reserved.

Nociception and role of immune system in pain.

Science.gov (United States)

Verma, Vivek; Sheikh, Zeeshan; Ahmed, Ahad S

2015-09-01

Both pain and inflammation are protective responses. However, these self-limiting conditions (with well-established negative feedback loops) become pathological if left uncontrolled. Both pain and inflammation can interact with each other in a multi-dimensional manner. These interactions are known to create an array of 'difficult to manage' pathologies. This review explains in detail the role of immune system and the related cells in peripheral sensitization and neurogenic inflammation. Various neuro-immune interactions are analyzed at peripheral, sensory and central nervous system levels. Innate immunity plays a critical role in central sensitization and in establishing acute pain as chronic condition. Moreover, inflammatory mediators also exhibit psychological effects, thus contributing towards the emotional elements associated with pain. However, there is also a considerable anti-inflammatory and analgesic role of immune system. This review also attempts to enlist various novel pharmacological approaches that exhibit their actions through modification of neuro-immune interface.

Age-Appropriate Immunization (AAI) as an Intractable Issue ...

African Journals Online (AJOL)

Dinesh Kumar

) approved. 30 cluster ... As FI measures coverage for services, but age appropriate ..... providers need to be effectively oriented towards importance of ... planning and management interventions for improving age- ... BMC Health Serv Res.

Attitudes of Swiss Health Care Providers Toward Childhood Immunizations.

Science.gov (United States)

Schuler, Marianne; Schaedelin, Sabine; Aebi, Christoph; Berger, Christoph; Crisinel, Pierre-Alex; Diana, Alessandro; Niederer-Loher, Anita; Siegrist, Claire-Anne; Vaudaux, Bernard; Heininger, Ulrich

2017-06-01

INFOVAC is a network providing information about immunization issues to health professionals. The aim of this study was to assess the attitude of INFOVAC subscribers toward the current Swiss immunization schedule, potential modifications, and current and hypothetical immunization practices regarding their own children. In March 2015, a Web-based survey was sent to 4260 physicians and pharmacists subscribed to INFOVAC. Participation was anonymous and voluntary. The following information was obtained: (1) current immunization status of own children; (2) which immunizations would currently be accepted for a hypothetical own child and (3) attitudes toward potential modifications of the Swiss immunization schedule. Descriptive methods and multivariate models to correct for covariables were used for data analysis. Nine hundred and fifty-five valid questionnaires were received: 886/3704 (23.9%) from physicians and 69/556 (12.4%) from pharmacists. Current (>95%) and hypothetical (>99%) immunization rates were high for diphtheria, tetanus, pertussis, poliomyelitis and measles-mumps-rubella. Most pediatricians (61%) would support more vaccines for their children than currently recommended by the Swiss immunization advisory committee, whereas about 50% of other physicians and pharmacists would decline at least one of the recommended immunizations, most frequently varicella, pneumococcal or meningococcal C conjugate vaccines. Strong general support was expressed for the expansion of human papillomavirus immunization to males, acceleration of the measles-mumps-rubella schedule and a 2 + 1 instead of 3 + 1 diphtheria-tetanus-pertussis, acellular-inactivated poliomyelitis vaccine (DTPa-IPV)/Haemophilus influenzae type b ± hepatitis B virus (HBV) schedule. Survey participants generally demonstrated a positive attitude toward immunization, with pediatricians being the most progressive subgroup with the largest percentage of participants (63.1%) neither declining nor postponing any

Environmental management in the USSR. Issue 9. Collection of papers

International Nuclear Information System (INIS)

Gratsiansky, A.N.

1991-01-01

The 9th English-language issue in the series 'Environmental management in the USSR' deals with expert assessment of programmes and relevant governmental decisions on the elimination of consequences of the Chernobyl accident. The collection features the Decision of the USSR Supreme Soviet 'On the Unified Programme for the Elimination of Consequences of the Chernobyl Nuclear Power Plant Accident and the Resultant Situation' adopted on 25 April 1990 and the Report of the Subcommission for State Programmes of the RSFSR, the Ukrainian SSR and the Byelorussian SSR for the Elimination of Consequences of the Chernobyl Nuclear Power Plant Accident in 1990-1995 under the Commission of Experts of the USSR State Planning Committee. To complement the corresponding sections of the Report the collection presents materials on the sociological, socio-psychological and medico-psychological dimensions of the expert appraisal of the general situation existing in the area suffering the consequences of the Chernobyl accident. The present publication has been suggested by the USSR Supreme Soviet Committee for Ecology and Natural Resources Management

Common management issues in pediatric patients with mild bleeding disorders.

Science.gov (United States)

O'Brien, Sarah H

2012-10-01

Type 1 von Willebrand disease and mild platelet function defects are among the most common disorders seen by pediatric hematologists. The management and prevention of bleeding in these patients can be challenging, as there are limited published data to guide clinical practice, and a complete lack of randomized clinical trials. Desmopressin (DDAVP) and antifibrinolytics are the mainstays of treatment in these patients, yet the optimal dosing and timing of these agents to prevent or resolve bleeding, while minimizing adverse side effects, is sometimes unclear. DDAVP-induced hyponatremia is a particularly under-recognized complication in children with bleeding disorders who undergo surgery. Clinicians need to be aware of local measures that are equally important in treating problems such as epistaxis and surgical bleeding. This review will discuss the published literature and provide practical suggestions regarding four common management issues in the care of children and adolescents with mild bleeding disorders: epistaxis, heavy menstrual bleeding, dental extractions, and tonsillectomy. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Artificial immune system applications in computer security

CERN Document Server

Tan, Ying

2016-01-01

This book provides state-of-the-art information on the use, design, and development of the Artificial Immune System (AIS) and AIS-based solutions to computer security issues. Artificial Immune System: Applications in Computer Security focuses on the technologies and applications of AIS in malware detection proposed in recent years by the Computational Intelligence Laboratory of Peking University (CIL@PKU). It offers a theoretical perspective as well as practical solutions for readers interested in AIS, machine learning, pattern recognition and computer security. The book begins by introducing the basic concepts, typical algorithms, important features, and some applications of AIS. The second chapter introduces malware and its detection methods, especially for immune-based malware detection approaches. Successive chapters present a variety of advanced detection approaches for malware, including Virus Detection System, K-Nearest Neighbour (KNN), RBF networ s, and Support Vector Machines (SVM), Danger theory, ...

Software management issues

International Nuclear Information System (INIS)

Kunz, P.F.

1990-06-01

The difficulty of managing the software in large HEP collaborations appears to becoming progressively worst with each new generation of detector. If one were to extrapolate to the SSC, it will become a major problem. This paper explores the possible causes of the difficulty and makes suggestions on what corrective actions should be taken

Risk Management Issues - An Aerospace Perspective

Science.gov (United States)

Perera, Jeevan S.

2011-01-01

Phased-approach for implementation of risk management is necessary. Risk management system will be simple, accessible and promote communication of information to all relevant stakeholders for optimal resource allocation and risk mitigation. Risk management should be used by all team members to manage risks--risk office personnel. Each group is assigned Risk Integrators who are facilitators for effective risk management. Risks will be managed at the lowest-level feasible, elevate only those risks that require coordination or management from above. Risk reporting and communication is an essential element of risk management and will combine both qualitative and quantitative elements.. Risk informed decision making should be introduced to all levels of management. Provide necessary checks and balances to insure that risks are caught/identified and dealt with in a timely manner, Many supporting tools, processes & training must be deployed for effective risk management implementation. Process improvement must be included in the risk processes.

Immune checkpoint inhibitors for non-small-cell lung cancer: does that represent a 'new frontier'?

Science.gov (United States)

Pilotto, Sara; Kinspergher, Stefania; Peretti, Umberto; Calio, Anna; Carbognin, Luisa; Ferrara, Roberto; Brunelli, Matteo; Chilosi, Marco; Tortora, Giampaolo; Bria, Emilio

2015-01-01

Advances in the interpretation and understanding of cancer behaviour, particularly of its ability to evade the host immunosurveillance, deregulating the balance between inhibitory and stimulatory factors, led to the development of an innovative category of immunotherapeutic agents, currently under investigation. Although the disappointing data deriving from the employment of vaccines in non-small cell lung cancer (NSCLC), more promising results have been obtained in the early phase trials with immune checkpoint inhibitors, such as cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4), programmed cell death protein-1 (PD-1) and programmed death-ligand 1 (PD-L1) inhibitors. This review delineates the main features of the available immunotherapeutic agents, focusing the discussion on immune checkpoint inhibitors, those that have already demonstrated a relevant clinical activity (such as Ipilimumab and Nivolumab) and those molecules still in early development phase. Moreover, we underline the possible emerging issues deriving from the progressive diffusion of Immuno-Oncology into the standard clinical practice. The careful and accurate identification and management of immune-related toxicities, the validation of more reliable immune response criteria and the increasing research of potential predictive biomarkers are key points of discussion. The perspective is that immunotherapy might represent an effective 'magic bullet', able to change the treatment paradigm of NSCLC, particularly of those subgroups featured by a heavily mutant cancer (squamous histology and smokers), where the immunologic agents contribute in cancer development and progression seems to be strong and, concurrently, the efficacy of standard therapies particularly limited.

Toward an Understanding of People Management Issues in SMEs: a South-Eastern European Perspective

Science.gov (United States)

Szamosi, Leslie T.; Duxbury, Linda; Higgins, Chris

2004-01-01

The focus of this paper is on developing an understanding, and benchmarking, human resource management HRM issues in small and medium enterprises SMEs in South-Eastern Europe. The importance of SMEs in helping transition-based economies develop is critical, but at the same time the research indicates that the movement toward westernized business…

Immunological considerations regarding parental concerns on pediatric immunizations.

Science.gov (United States)

Nicoli, Francesco; Appay, Victor

2017-05-25

Despite the fundamental role of vaccines in the decline of infant mortality, parents may decide to decline vaccination for their own children. Many factors may influence this decision, such as the belief that the infant immune system is weakened by vaccines, and concerns have been raised about the number of vaccines and the early age at which they are administered. Studies focused on the infant immune system and its reaction to immunizations, summarized in this review, show that vaccines can overcome those suboptimal features of infant immune system that render them more at risk of infections and of their severe manifestations. In addition, many vaccines have been shown to improve heterologous innate and adaptive immunity resulting in lower mortality rates for fully vaccinated children. Thus, multiple vaccinations are necessary and not dangerous, as infants can respond to several antigens as well as when responding to single stimuli. Current immunization schedules have been developed and tested to avoid vaccine interference, improve benefits and reduce side effects compared to single administrations. The infant immune system is therefore capable, early after birth, of managing several antigenic challenges and exploits them to prompt its development. Copyright © 2017 Elsevier Ltd. All rights reserved.

Social, ethical and moral issues in the implementation of radioactive waste management objectives

International Nuclear Information System (INIS)

Abrahamson, D.E.

1976-01-01

To date, the management of nuclear waste has included sizable releases to the environment. The economic result of these releases is opposed by the ethical issue. Questions of who will be responsible for the wastes are asked. The danger of trusting the experts is pointed out: information is withheld, data are suppressed, etc. The nuclear industry needs to restore confidence, but restoring competence must come first

The Role of Nuclear Medicine in the Staging and Management of Human Immune Deficiency Virus Infection and Associated Diseases.

Science.gov (United States)

Ankrah, Alfred O; Glaudemans, Andor W J M; Klein, Hans C; Dierckx, Rudi A J O; Sathekge, Mike

2017-06-01

Human immune deficiency virus (HIV) is a leading cause of death. It attacks the immune system, thereby rendering the infected host susceptible to many HIV-associated infections, malignancies and neurocognitive disorders. The altered immune system affects the way the human host responds to disease, resulting in atypical presentation of these disorders. This presents a diagnostic challenge and the clinician must use all diagnostic avenues available to diagnose and manage these conditions. The advent of highly active antiretroviral therapy (HAART) has markedly reduced the mortality associated with HIV infection but has also brought in its wake problems associated with adverse effects or drug interaction and may even modulate some of the HIV-associated disorders to the detriment of the infected human host. Nuclear medicine techniques allow non-invasive visualisation of tissues in the body. By using this principle, pathophysiology in the body can be targeted and the treatment of diseases can be monitored. Being a functional imaging modality, it is able to detect diseases at the molecular level, and thus it has increased our understanding of the immunological changes in the infected host at different stages of the HIV infection. It also detects pathological changes much earlier than conventional imaging based on anatomical changes. This is important in the immunocompromised host as in some of the associated disorders a delay in diagnosis may have dire consequences. Nuclear medicine has played a huge role in the management of many HIV-associated disorders in the past and continues to help in the diagnosis, prognosis, staging, monitoring and assessing the response to treatment of many HIV-associated disorders. As our understanding of the molecular basis of disease increases nuclear medicine is poised to play an even greater role. In this review we highlight the functional basis of the clinicopathological correlation of HIV from a metabolic view and discuss how the use of

The role of nuclear medicine in the staging and management of human immune deficiency virus infection and associated diseases

International Nuclear Information System (INIS)

Ankrah, Alfred O.; Sathekge, Mike; Glaudemans, Andor W. J. M.; Klein, Hans; Dierckx, Rudi A. J. O.

2017-01-01

Human immune deficiency virus (HIV) is a leading cause of death. It attacks the immune system, thereby rendering the infected host susceptible to many HIV-associated infections, malignancies and neurocognitive disorders. The altered immune system affects the way the human host responds to disease, resulting in atypical presentation of these disorders. This presents a diagnostic challenge and the clinician must use all diagnostic avenues available to diagnose and manage these conditions. The advent of highly active antiretroviral therapy (HAART) has markedly reduced the mortality associated with HIV infection but has also brought in its wake problems associated with adverse effects or drug interaction and may even modulate some of the HIV-associated disorders to the detriment of the infected human host. Nuclear medicine techniques allow non-invasive visualisation of tissues in the body. By using this principle, pathophysiology in the body can be targeted and the treatment of diseases can be monitored. Being a functional imaging modality, it is able to detect diseases at the molecular level, and thus it has increased our understanding of the immunological changes in the infected host at different stages of the HIV infection. It also detects pathological changes much earlier than conventional imaging based on anatomical changes. This is important in the immunocompromised host as in some of the associated disorders a delay in diagnosis may have dire consequences. Nuclear medicine has played a huge role in the management of many HIV-associated disorders in the past and continues to help in the diagnosis, prognosis, staging, monitoring and assessing the response to treatment of many HIV-associated disorders. As our understanding of the molecular basis of disease increases nuclear medicine is poised to play an even greater role. In this review we highlight the functional basis of the clinicopathological correlation of HIV from a metabolic view and discuss how the use of

The role of nuclear medicine in the staging and management of human immune deficiency virus infection and associated diseases

Energy Technology Data Exchange (ETDEWEB)

Ankrah, Alfred O.; Sathekge, Mike [Dept. of Nuclear Medicine, University of Pretoria and Steve Biko Academic Hospital, Pretoria (South Africa); Glaudemans, Andor W. J. M.; Klein, Hans; Dierckx, Rudi A. J. O. [University of Groningen, University Medical Centre Groningen, Groningen (Netherlands)

2017-06-15

Human immune deficiency virus (HIV) is a leading cause of death. It attacks the immune system, thereby rendering the infected host susceptible to many HIV-associated infections, malignancies and neurocognitive disorders. The altered immune system affects the way the human host responds to disease, resulting in atypical presentation of these disorders. This presents a diagnostic challenge and the clinician must use all diagnostic avenues available to diagnose and manage these conditions. The advent of highly active antiretroviral therapy (HAART) has markedly reduced the mortality associated with HIV infection but has also brought in its wake problems associated with adverse effects or drug interaction and may even modulate some of the HIV-associated disorders to the detriment of the infected human host. Nuclear medicine techniques allow non-invasive visualisation of tissues in the body. By using this principle, pathophysiology in the body can be targeted and the treatment of diseases can be monitored. Being a functional imaging modality, it is able to detect diseases at the molecular level, and thus it has increased our understanding of the immunological changes in the infected host at different stages of the HIV infection. It also detects pathological changes much earlier than conventional imaging based on anatomical changes. This is important in the immunocompromised host as in some of the associated disorders a delay in diagnosis may have dire consequences. Nuclear medicine has played a huge role in the management of many HIV-associated disorders in the past and continues to help in the diagnosis, prognosis, staging, monitoring and assessing the response to treatment of many HIV-associated disorders. As our understanding of the molecular basis of disease increases nuclear medicine is poised to play an even greater role. In this review we highlight the functional basis of the clinicopathological correlation of HIV from a metabolic view and discuss how the use of

Strategic Issues for Training.

Science.gov (United States)

Pollitt, David, Ed.

1999-01-01

Contains precis of 18 articles on strategic management issues, including management development, on-the-job training, corporate scholarship, educational technology, coaching, investing in intellectual capital, and knowledge management. (SK)

Workplace bullying: an emergent issue.

Science.gov (United States)

Essen, S Donovan; Esquivel, Cynthia; Jha, Pankaj

2014-09-01

All companies, including dentists, rely on their staff to represent their firms in the most positive and effective manner. Today's managers face a multitude of issues, and as such, they must walk a fine line of fostering a productive, harmonious and safe working environment for their employees. Over the last several decades it is apparent that on the- job sexual harassment is no longer the leading issue of employee complaints. Rather, the organization issue which was investigated is workplace bullying, also commonly referred to as employee harassment. Risk management is no longer limited to avoiding malpractice issues but also preventing litigation created by poor organizational behavior. The primary purpose of this paper is to explore the background of workplace bullying and how it affects today's managers and their employees, customers and suppliers. In other words, the scope of this paper will feature research on past studies, results and conclusions. Since workplace bullying affects all levels of a corporation, it must be stated that the concern and focus of this paper is for today's manager to understand the background and history of workplace bullying, and what they can do to foster a safe working environment and prevent the bully from creating mental and physical harm to their employees. This paper details the history of workplace bullying and how management, employees and suppliers deal with and address the issue. Lastly, this treatise looks at risk management from a manger/dentist's perspective, the assessment/conclusion summarizes the implications for managers regarding how they must handle the issue or risk harm to the employee and/or serious legal ramifications.

Managing and developing key supplier relationships : An introduction to the special issue, discussion and implications

NARCIS (Netherlands)

Ivens, B.; van de Vijver, M.A.R.; Vos, G.C.J.M.

2013-01-01

This article provides an introduction to this special issue on managing and developing key supplier relationships. Key suppliers are increasingly seen as strategic assets of buying companies which need careful nurturing to fully utilize their potential for value creation. The six articles of this

Managing and Mobilising Talent in Malaysia: Issues, Challenges and Policy Implications for Malaysian Universities

Science.gov (United States)

Azman, Norzaini; Sirat, Morshidi; Pang, Vincent

2016-01-01

The future of Malaysia as a high-income and competitive nation largely depends on its pool of highly skilled human capital. Hence, the issue of human capital development has taken centre stage in numerous reform agendas of Malaysia. This paper seeks to provide examples of policy initiatives aimed at facilitating the management of highly educated…

Role of MicroRNAs in Obesity-Induced Metabolic Disorder and Immune Response

Directory of Open Access Journals (Sweden)

Hong Zhong

2018-01-01

Full Text Available In all living organisms, metabolic homeostasis and the immune system are the most fundamental requirements for survival. Recently, obesity has become a global public health issue, which is the cardinal risk factor for metabolic disorder. Many diseases emanating from obesity-induced metabolic dysfunction are responsible for the activated immune system, including innate and adaptive responses. Of note, inflammation is the manifest accountant signal. Deeply studied microRNAs (miRNAs have participated in many pathways involved in metabolism and immune responses to protect cells from multiple harmful stimulants, and they play an important role in determining the progress through targeting different inflammatory pathways. Thus, immune response and metabolic regulation are highly integrated with miRNAs. Collectively, miRNAs are the new targets for therapy in immune dysfunction.

Design principles and issues of rights expression languages for digital rights management

Science.gov (United States)

Wang, Xin

2005-07-01

Digital rights management (DRM) provides a unified approach to specifying, interpreting, enforcing and managing digital rights throughout the entire life cycle of digital assets. Using a declarative rights expression language (REL) for specifying rights and conditions in the form of licenses, as opposite to some other approaches (such as data structures and imperative languages), has been considered and adopted as a superior technology for implementing effective, interoperable and scalable DRM systems. This paper discusses some principles and issues for designing RELs, based on the experiences of developing a family of REL"s (DPRL, XrML 1.x, XrML 2.0 and MPEG REL). It starts with an overview of a family tree of the past and current REL"s, and their development history, followed by an analysis of their data models and a comparison with access-control oriented models. It then presents a number of primary design principles such as syntactic and semantic un-ambiguity, system interoperability, expressiveness in supporting business models and future extensibility, and discusses a number of key design issues such as maintaining stateful information, multi-tier issuance of rights, meta rights, identification of individual and aggregate objects, late-binding of to-beidentified entities, as well as some advanced ones on revocation and delegation of rights. The paper concludes with some remarks on REL profiling and extension for specific application domains.

ISSUES ON THE ROLE OF EFFICIENT WATER PRICING FOR SUSTAINABLE WATER MANAGEMENT

Directory of Open Access Journals (Sweden)

Simona FRONE

2012-06-01

Full Text Available This paper aims to highlight some of the main issues raised by developing and implementing the most appropriate approach to water pricing, and to induce a sustainable water management. Therefore, we define the concept and utility of water demand management as one objective of efficient water pricing. Next we analyse the basic economics and some important theoretical insights of water pricing. We further with state the main four inter-correlated principles of sustainable water pricing (full-cost recovery, economic efficiency,equity and administrative feasability and the trends and challenges of their actual implementing in the water pricing policy of Romania and other EU countries. We end with a review of opinions, personal conclusions and recommendations on the actual opportunity, effectiveness and role of efficient water pricing in fulfilling the goals of sustainabilty.

It Security Issues Within the Video Game Industry

OpenAIRE

STEPHEN MOHR; SYED (SHAWON) RAHMAN,

2011-01-01

IT security issues are an important aspect for each and every organization within the video game industry. Within the video game industry alone, you might not normally think of security risks being an issue. But as we can and have seen in recent news, no company is immune to security risks no matter how big or how small. While each of these organizations will never be exactly the same as the next, there are common security issues that can and do affect each and every video game company. In or...

The changing training needs of clinical nurse managers: exploring issues for continuing professional development.

Science.gov (United States)

Gould, D; Kelly, D; Goldstone, L; Maidwell, A

2001-04-01

To identify areas where clinical nurse managers perceived that they would benefit from further training and to make recommendations for planning future programmes to meet their needs. The effectiveness of the clinical nurse manager has traditionally been associated with maintaining standards of care. Continuing professional development (CPD) is essential to ensure this important group feel adequately prepared to perform their role and has been recognized as an important factor in maintaining job satisfaction and reducing wasteful staff turnover. A review of the literature indicated that since the 1980s the CPD needs of clinical nurse managers have tended to be overlooked despite increasing complexity of the tasks expected of them. Thus it appeared that a fresh study to address these needs would be justified and should take into account sources of work-related stress and variables relating to job satisfaction. The study involved clinical nurse managers employed in all four acute hospital National Health Service (NHS) trusts where training needs were served by a major inner city educational consortium. Data collection proceeded in two stages. Initially interviews were undertaken with a random sample of 15 clinical nurse managers to provide in-depth, qualitative data. This information was used to develop a survey questionnaire distributed to the remaining 182 clinical nurse managers in each of the trusts. Data from the interviews indicated that clinical nurse managers appeared to feel clinically competent but generally experienced lack of confidence when dealing with a range of issues, in particular; human resources, managing budgets, deputizing for senior colleagues across the trust ('acting up') and using information technology in everyday practice. Response rate to the survey was good (65%). The results corroborated the interview findings, indicating a need for updating in the same wide range of topics. There were few differences in training needs across all four

ANALYSIS OF FACTORS CAUSE LOW INFANT IMMUNIZATION ACHIEVEMENTS IN TANJUNGSARI CLINICSANALYSIS OF FACTORS CAUSE LOW INFANT IMMUNIZATION ACHIEVEMENTS IN PUBLIC HEALTH DISTRIC

Directory of Open Access Journals (Sweden)

Juni Kurnia Santi

2016-07-01

Full Text Available Immunization is a promotif and preventive efforts in basic health services play an important role in the decline of infant mortality that occurs due to a disease that can be prevented by immunization (PD3I. Annual reports from public health Tanjungsari noted that the results of the coverage of immunization activities results of the baby has not yet reached the target UCI (Uneversal Child Immunization. An assumption of the reason for immunization low coverage was the way on how Public Heath Center implemented its management funtion : planning, actuacting (supervision, coordination, cold chain, work load, motivation, evaluating and the result of baby`s immunization program. The risset of study is observational study. tanjunsari Public Health Center district the unit of analysis of this study. The object of study was all immunization program documentation which constituted of planning, implementation, supervision check list, coordination check list, evaluation documents as well as the document of coverage results. The respondent were the personnel of immunization program. The results of study revealed baby`s immunization until four years old is 86% campak, 89% DPT1, 86% DPT3, 87% Polio4, 84% BCG dan 85% HB3. Conclusively, it can derived that was discovered that the coverage of baby`s immunization was far below the UCI (Universal Child Immunization standart in public health, implementatiton (supervision, coordination, clod chain, load work, motivation and evaluating immunization program has nor been performed well. The inhibiting factors are now knowledge the process Planning Of Action formulation, no supervision to immunization program dan insufficient motivation to personnel immunization program. Key words : planning, immunization program, Public Health

Understanding Cultural Issues in Diabetes Self-Management Behaviors of Korean Immigrants

Science.gov (United States)

Cha, Eun Seok; Yang, Kyeongra; Lee, Jia; Min, Jiwon; Kim, Kevin H.; Dunbar, Sandra B.; Jennings, Bonnie Mowinski

2013-01-01

Purpose The purpose of this study was to explore potential factors affecting self-management behaviors in Korean immigrants with type 2 diabetes mellitus (KIT2Ds). Methods A qualitative descriptive design guided this study. Semi-structured interviews lasting 45-60 minutes were conducted with 20 KIT2Ds in the participant’s preferred language; in all cases this was Korean. Each interview was audio-taped, transcribed, and analyzed using conventional content analysis. Data analysis was performed in two steps. The data written in Korean were initially analyzed by three bilingual researchers. A qualitative researcher then participated in the analysis to refine the findings for presentation to an English speaking audience while staying true to the data and preserving the nuanced Korean meanings. Results The mean age of the sample was 64. 5 ± 11.6 years (9 men and 11 women). The mean years of staying in the U. S. and age at diabetes mellitus diagnosis were 23.6 ± 9.7 years and 52.5 ± 12.3 years, respectively. Three major ideas were identified: (a) issues on treatment regimen related to both medications and diet, (b) resources that helped or hindered their ability to manage diabetes, and (c) the physician/patient relationship. Conclusions There were important cultural nuances that need to be addressed to better prepare KIT2Ds to manage their diabetes more effectively. A culture specific program should extend beyond a diabetes self-management education delivered in Korean language. Rather, content and education methods need to consider acculturation effects on diabetes management behaviors. PMID:23019236

American Health Information Management Association. Position statement. Issue: managing health information in facility mergers and acquisitions.

Science.gov (United States)

1994-04-01

Healthcare facility mergers and acquisitions are becoming more common as the industry consolidates. Many critical issues must be considered in mergers and acquisitions, including the management of patient health information. In addition to operational issues, licensure, regulatory, and accreditation requirements must be addressed. To ensure availability of health information to all legitimate users, patient records should be consolidated or linked in the master patient index. A record retention policy should be developed and implemented to meet user needs and assure compliance with legal, regulatory, and accreditation requirements. If health information from closed facilities will be stored for a period of time, its integrity and confidentiality must be preserved, and it must be readily accessible for patient care. The compatibility and functionality of existing information systems should be assessed, and a plan should be formulated for integration of the systems to the extent possible. Such integration may be essential for the organization to successfully meet the demands of integrated delivery systems. Existing databases should be maintained in an accessible form to meet anticipated future needs.

Improving immunization in Afghanistan: results from a cross-sectional community-based survey to assess routine immunization coverage

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Raveesha R. Mugali

2017-04-01

Full Text Available Abstract Background Despite progress in recent years, Afghanistan is lagging behind in realizing the full potential of immunization. The country is still endemic for polio transmission and measles outbreaks continue to occur. In spite of significant reductions over the past decade, the mortality rate of children under 5 years of age continues to remain high at 91 per 1000 live births. Methods The study was a descriptive community-based cross sectional household survey. The survey aimed to estimate the levels of immunization coverage at national and province levels. Specific objectives are to: establish valid baseline information to monitor progress of the immunization program; identify reasons why children are not immunized; and make recommendations to enhance access and quality of immunization services in Afghanistan. The survey was carried out in all 34 provinces of the country, with a sample of 6125 mothers of children aged 12–23 months. Results Nationally, 51% of children participating in the survey received all doses of each antigen irrespective of the recommended date of immunization or recommended interval between doses. About 31% of children were found to be partially vaccinated. Reasons for partial vaccination included: place to vaccinate child too far (23%, not aware of the need of vaccination (17%, no faith in vaccination (16%, mother was too busy (15%, and fear of side effects (11%. Conclusion The innovative mechanism of contracting out delivery of primary health care services in Afghanistan, including immunization, to non-governmental organizations is showing some positive results in quickly increasing coverage of essential interventions, including routine immunization. Much ground still needs to be covered with proper planning and management of resources in order to improve the immunization coverage in Afghanistan and increase survival and health status of its children.

How supportive supervision influences immunization session site practices: a quasi-experimental study in Odisha, India

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Bhuputra Panda

2015-01-01

Full Text Available Background: Routine immunization (RI is a key child survival intervention. Ensuring acceptable standards of RI service delivery is critical for optimal outcomes. Accumulated evidences suggest that ‘supportive supervision’ improves the quality of health care services in general. During 2009–2010, the Government of Odisha and UNICEF jointly piloted this strategy in four districts to improve RI program outcomes. The present study aims to assess the effect of this strategy on improvement of skills and practices at immunization session sites. Design: A quasi-experimental ‘post-test only’ study design was adopted to compare the opinion and practices of frontline health workers and their supervisors in four intervention districts (IDs with two control districts (CDs. Altogether, we interviewed 111 supervisor–supervisee (health worker pairs using semi-structured interview schedules and case vignettes. We also directly observed health workers’ practices during immunization sessions at 111 sites. Data were analyzed with SPSS version 16.0. Results: The mean knowledge score of supervisors in CDs was significantly higher than in intervention groups. Variegated responses were obtained on case vignettes. The control group performed better in solving certain hypothetically asked problems, whereas the intervention group scored better in others. Health workers in IDs gave a lower rating to their respective supervisors’ knowledge, skill, and frequency of supervision. Logistics and vaccine availability were better in CDs. Conclusion: Notwithstanding other limitations, supportive supervision may not have independent effects on improving the quality of immunization services. Addressing systemic issues, such as the availability of essential logistics, supply chain management, timely indenting, and financial resources, could complement the supportive supervision strategy in improving immunization service delivery.

Effective vaccine safety systems in all countries: a challenge for more equitable access to immunization.

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Amarasinghe, Ananda; Black, Steve; Bonhoeffer, Jan; Carvalho, Sandra M Deotti; Dodoo, Alexander; Eskola, Juhani; Larson, Heidi; Shin, Sunheang; Olsson, Sten; Balakrishnan, Madhava Ram; Bellah, Ahmed; Lambach, Philipp; Maure, Christine; Wood, David; Zuber, Patrick; Akanmori, Bartholomew; Bravo, Pamela; Pombo, María; Langar, Houda; Pfeifer, Dina; Guichard, Stéphane; Diorditsa, Sergey; Hossain, Md Shafiqul; Sato, Yoshikuni

2013-04-18

Serious vaccine-associated adverse events are rare. To further minimize their occurrence and to provide adequate care to those affected, careful monitoring of immunization programs and case management is required. Unfounded vaccine safety concerns have the potential of seriously derailing effective immunization activities. To address these issues, vaccine pharmacovigilance systems have been developed in many industrialized countries. As new vaccine products become available to prevent new diseases in various parts of the world, the demand for effective pharmacovigilance systems in low- and middle-income countries (LMIC) is increasing. To help establish such systems in all countries, WHO developed the Global Vaccine Safety Blueprint in 2011. This strategic plan is based on an in-depth analysis of the vaccine safety landscape that involved many stakeholders. This analysis reviewed existing systems and international vaccine safety activities and assessed the financial resources required to operate them. The Blueprint sets three main strategic goals to optimize the safety of vaccines through effective use of pharmacovigilance principles and methods: to ensure minimal vaccine safety capacity in all countries; to provide enhanced capacity for specific circumstances; and to establish a global support network to assist national authorities with capacity building and crisis management. In early 2012, the Global Vaccine Safety Initiative (GVSI) was launched to bring together and explore synergies among on-going vaccine safety activities. The Global Vaccine Action Plan has identified the Blueprint as its vaccine safety strategy. There is an enormous opportunity to raise awareness for vaccine safety in LMIC and to garner support from a large number of stakeholders for the GVSI between now and 2020. Synergies and resource mobilization opportunities presented by the Decade of Vaccines can enhance monitoring and response to vaccine safety issues, thereby leading to more equitable

Controversial Issues in Thyroid Cancer Management.

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Tuttle, R Michael

2018-04-13

The lack of prospective randomized clinical trials for most management topics in differentiated thyroid cancer force us to make management recommendations based on retrospective observational data which is often incomplete, subject to selection bias, and conflicting. Therefore, it is not surprising that many aspects of thyroid cancer management remain controversial and not well defined. This review will examine the controversies surrounding three important topics in thyroid cancer management: (1) the option of thyroid lobectomy as initial therapy for thyroid cancer, (2) the proper use of preoperative neck imaging to optimize the completeness of the initial surgical procedure, and (3) the selective use RAI therapy as remnant ablation, adjuvant treatment or treatment of known persistent/recurrent disease. As thyroid cancer management moves toward a much more risk adapted approach to personalized management recommendations, clinicians and patients must balance the risks and benefits of the potential management options to arrive at a management plan that is optimized based on both patient preferences/values and the philosophy/experience of the local disease management team. Copyright © 2018 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

Inernational research in health care management: its need in the 21st century, methodological challenges, ethical issues, pitfalls, and practicalities.

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Buttigieg, Sandra C; Rathert, Cheryl; D'Aunno, Thomas A; Savage, Grant T

2015-01-01

This commentary argues in favor of international research in the 21st century. Advances in technology, science, communication, transport, and infrastructure have transformed the world into a global village. Industries have increasingly adopted globalization strategies. Likewise, the health sector is more internationalized whereby comparisons between diverse health systems, international best practices, international benchmarking, cross-border health care, and cross-cultural issues have become important subjects in the health care literature. The focus has now turned to international, collaborative, cross-national, and cross-cultural research, which is by far more demanding than domestic studies. In this commentary, we explore the methodological challenges, ethical issues, pitfalls, and practicalities within international research and offer possible solutions to address them. The commentary synthesizes contributions from four scholars in the field of health care management, who came together during the annual meeting of the Academy of Management to discuss with members of the Health Care Management Division the challenges of international research. International research is worth pursuing; however, it calls for scholarly attention to key methodological and ethical issues for its success. This commentary addresses salient issues pertaining to international research in one comprehensive account.

The Issues of Track Maintenance Management in Indonesia (Based on Study of the British Railways

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Tetria Yunik Dewi Pamungkas

2017-01-01

Full Text Available It is believed that there is merit in researching how the management of track maintenance is organized in the United Kingdom, in particular by Network Rail, and then evaluating how this can be applied to the benefit of Indonesian Railways. The purpose of this research was expected to provide recommendations for management improvement of track maintenance by researching the track maintenance management system in Network Rail. This research study is based on secondary data. The analysis was conducted by using comparison method which compares the British Railways management and Indonesia railway management related to track maintenance management. The track maintenance management system was studied by using Network Rail. The results were compared with track maintenance management system in Indonesia. The comparison will provide the data differences that evaluated so the problem can be identified. The final result of this analysis was the identification of problems and improvisation that can be done for the development of track maintenance management in Indonesia. Several management issues have been mapped to several groups: finance management, structure organization, and asset management. From the problems that have been mapped, some improvements are recommended as monopolist authority restriction, maintenance system contract extension, re-structuring organization hierarchy, business plan consideration, track monitoring strategy arrangement, and condition based maintenance strategy adoption.

Provider Preferences and Experiences With a Countywide Centralized Collaborative Reminder/Recall for Childhood Immunizations.

Science.gov (United States)

Saville, Alison W; Gurfinkel, Dennis; Sevick, Carter; Beaty, Brenda; Dickinson, L Miriam; Kempe, Allison

2016-01-01

To assess among providers in 7 Colorado counties where a collaborative centralized reminder/recall (CC-R/R) using the Colorado Immunization Information System (CIIS) was performed: 1) preferences about CC-R/R conducted by the public health department (PHD); 2) preferences for future CC-R/R for different vaccines with and without practice names; and 3) experiences with including their name on CC-R/R notices. A mailed survey was sent to all primary care sites where CC-R/R had been previously conducted. Respondents self-identified as the "the person in charge of immunization policy within the practice." Overall response rate was 69.9% (160 of 229). Twenty-one were removed because they did not provide immunizations to children. Among respondents, 65.0% were from family medicine and 26.3% from pediatric practices; 32.1% physicians or midlevel providers; 34.3% nurses or medical assistants; and 33.6% office managers. Taking into account all issues, 57.6% were "okay" with either the PHD or their practice conducting recall; 27.3% preferred the PHD; and 14.4% preferred their practice conduct R/R. Fifty-six percent of active CIIS practices (n = 95) included their practice's name on CC-R/R notices. Interest in future CC-R/R for different ages and vaccines was strongly related to whether reminders included the practice name: 77.8% for routine immunizations in 4- to 6-year-olds; 74.8% for immunizations for 0- to 3-year-olds; 73.3% for vaccines administered to adolescents; and 59.7% for influenza (P < .001). Most practices are accepting of the PHD centrally conducting R/R, but most prefer collaboration that includes their name. Given the success and support of this method, it should be more widely adopted. Copyright © 2016 Academic Pediatric Association. Published by Elsevier Inc. All rights reserved.

The environment as a driver of immune and endocrine responses in dolphins (Tursiops truncatus.

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Patricia A Fair

Full Text Available Immune and endocrine responses play a critical role in allowing animals to adjust to environmental perturbations. We measured immune and endocrine related markers in multiple samples from individuals from two managed-care care dolphin groups (n = 82 samples from 17 dolphins and single samples collected from two wild dolphin populations: Indian River Lagoon, (IRL FL (n = 26; and Charleston, (CHS SC (n = 19. The immune systems of wild dolphins were more upregulated than those of managed-care-dolphins as shown by higher concentrations of IgG and increases in lysozyme, NK cell function, pathogen antibody titers and leukocyte cytokine transcript levels. Collectively, managed-care care dolphins had significantly lower levels of transcripts encoding pro-inflammatory cytokine TNF, anti-viral MX1 and INFα and regulatory IL-10. IL-2Rα and CD69, markers of lymphocyte activation, were both lower in managed-care care dolphins. IL-4, a cytokine associated with TH2 activity, was lower in managed-care care dolphins compared to the free-ranging dolphins. Differences in immune parameters appear to reflect the environmental conditions under which these four dolphin populations live which vary widely in temperature, nutrition, veterinary care, pathogen/contaminant exposures, etc. Many of the differences found were consistent with reduced pathogenic antigenic stimulation in managed-care care dolphins compared to wild dolphins. Managed-care care dolphins had relatively low TH2 lymphocyte activity and fewer circulating eosinophils compared to wild dolphins. Both of these immunologic parameters are associated with exposure to helminth parasites which is uncommon in managed-care care dolphins. Less consistent trends were observed in a suite of hormones but significant differences were found for cortisol, ACTH, total T4, free T3, and epinephrine. While the underlying mechanisms are likely multiple and complex, the marked differences observed in the immune and endocrine

Issues management - Internet in environmental scanning. A strategic weapon or just another fancy toy? (situation in Finland)

International Nuclear Information System (INIS)

Kuorikoski, Pia

1998-01-01

The objective of the study is to find out how different international industrial companies in Finland use the Internet as a tool in the environmental scanning process and in issues management as well. Is Internet used at all in this respect? Prime target is to find an easy way to monitor future developments via Internet and in that sense be able to forecast the future issues and develop the process of issues management. The study is descriptive and its purpose is not to shake walls but realistically describe Internet's scanning possibilities in everyday life. Communication managers in eight different Finnish companies were interviewed. Issues management and environmental scanning are parts of an organisation's strategic planning. Strategic plans are not available even for academic researchers unless the results of the study are kept secret. The level of the results of this study is therefore practical and simplistic. This chapter tells briefly some of the results gained from research. It seems that at least big forest companies use Internet a lot but because of the strategic matters involved they did not reveal all their scanning details. In general it seems that communication managers in Finland don't yet use all the available possibilities that the Internet can offer to the process of environmental scanning. Internet is still quite a new tool. Traditional information gathering techniques are still more appreciated, for instance personal contacts with environmental activists are highly valued and a common way to get information about the future events. The culture of environmental activism in Finland has moved towards quite an open direction recently. Activists can call the companies' information personnel to let them know that they are going to demonstrate in the backyard of a company and invite international press to film the show - the actions are open. There are some militant groups, however, that operate differently and hints about their actions and current

Sustainability issues for resource managers.

Science.gov (United States)

Daniel L. Bottom; Gordon H. Reeves; Martha H. Brookes

1996-01-01

Throughout their history, conservation science and sustainable-yield management have failed to maintain the productivity of living resources. Repeated overexploitation of economic species, loss of biological diversity, and degradation of regional environments now call into question the economic ideas and values that have formed the foundation of scientific management...

Availability and utilization of opioids for pain management: global issues.

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Manjiani, Deepak; Paul, D Baby; Kunnumpurath, Sreekumar; Kaye, Alan David; Vadivelu, Nalini

2014-01-01

Pain can significantly influence an individual's health status and can have serious negative consequences: poor nutrition, decreased appetite, abnormal sleep patterns, fatigue, and impairment of daily living activities. Pain can cause psychological impairment and decrease healing and recovery from injuries and illness. A hallmark of many chronic conditions, pain affects more patients' lives than diabetes mellitus, heart disease, and cancer combined. However, many chronic sufferers do not have access to effective pain management for a variety of reasons, including limited access, restrictions, and personal and cultural biases. This review summarizes issues of access, distribution, and cultural bias with regard to opioid agents and seeks to clarify the challenges related to opioid delivery. The considerable negative physical and mental consequences of chronic pain are discussed for the general and palliative care population. Opioids are an effective treatment for various intractable painful conditions, but problems in global opioid access for safe and rational use in pain management contribute to unnecessary suffering. These problems persist despite increased understanding in recent years of the pathophysiology of pain. Comprehensive guidelines for goal-directed and patient-friendly chronic opiate therapy will potentially enhance the outlook for future chronic pain management. The improvement of pain education in undergraduate and postgraduate training will benefit patients and clinicians. The promise of new medications, along with the utilization of multimodal approaches, has the potential to provide effective pain relief to future generations of sufferers.

Modulation of immune responses in stress by Yoga

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Arora Sarika

2008-01-01

Full Text Available Stress is a constant factor in today′s fastpaced life that can jeopardize our health if left unchecked. It is only in the last half century that the role of stress in every ailment from the common cold to AIDS has been emphasized, and the mechanisms involved in this process have been studied. Stress influences the immune response presumably through the activation of the hypothalamic-pituitary adrenal axis, hypothalamic pituitary-gonadal axis, and the sympathetic-adrenal-medullary system. Various neurotransmitters, neuropeptides, hormones, and cytokines mediate these complex bidirectional interactions between the central nervous system (CNS and the immune system. The effects of stress on the immune responses result in alterations in the number of immune cells and cytokine dysregulation. Various stress management strategies such as meditation, yoga, hypnosis, and muscle relaxation have been shown to reduce the psychological and physiological effects of stress in cancers and HIV infection. This review aims to discuss the effect of stress on the immune system and examine how relaxation techniques such as Yoga and meditation could regulate the cytokine levels and hence, the immune responses during stress.

When carbon nanotubes encounter the immune system: desirable and undesirable effects.

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Dumortier, Hélène

2013-12-01

The role of our immune system is to bring efficient protection against invasion by foreign elements, not only pathogens but also any material it may be in contact with. Nanoparticles may enter the body and encounter the immune system either intentionally (e.g. administration for biomedical application) or not (e.g. respiratory occupational exposure). Therefore, it is of fundamental importance to get a thorough knowledge of the way they interact with immune cells and all related consequences. Among nanomaterials, carbon nanotubes (CNTs) are of special interest because of their tremendous field of applications. Consequently, their increasing production, processing and eventual incorporation into new types of composites and/or into biological systems have raised fundamental issues regarding their potential impact on health. This review aims at giving an overview of the known desirable and undesirable effects of CNTs on the immune system, i.e. beneficial modulation of immune cells by CNTs engineered for biomedical applications versus toxicity, inflammation and unwanted immune reactions triggered by CNTs themselves. © 2013 Elsevier B.V. All rights reserved.

An Analysis of Technological Issues Emanating from Faculty Transition to a New Learning Management System

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Sanga, Mapopa William

2016-01-01

This case study investigated the process 119 faculty members underwent as they transitioned from using Desire to Learn (D2L) learning management system (LMS), to using Canvas LMS. Other than analyzing technological issues faculty members encountered while navigating various aspects of the Canvas interface, the study also analyzed technological…

Strengthening health system to improve immunization for migrants in China.

Science.gov (United States)

Fang, Hai; Yang, Li; Zhang, Huyang; Li, Chenyang; Wen, Liankui; Sun, Li; Hanson, Kara; Meng, Qingyue

2017-07-01

Immunization is the most cost-effective method to prevent and control vaccine-preventable diseases. Migrant population in China has been rising rapidly, and their immunization status is poor. China has tried various strategies to strengthen its health system, which has significantly improved immunization for migrants. This study applied a qualitative retrospective review method aiming to collect, analyze and synthesize health system strengthening experiences and practices about improving immunizations for migrants in China. A conceptual framework of Theory of Change was used to extract the searched literatures. 11 searched literatures and 4 national laws and policies related to immunizations for migrant children were carefully studied. China mainly employed 3 health system strengthening strategies to significantly improve immunization for migrant population: stop charging immunization fees or immunization insurance, manage immunization certificates well, and pay extra attentions on immunization for special children including migrant children. These health system strengthening strategies were very effective, and searched literatures show that up-to-date and age-appropriate immunization rates were significantly improved for migrant children. Economic development led to higher migrant population in China, but immunization for migrants, particularly migrant children, were poor. Fortunately various health system strengthening strategies were employed to improve immunization for migrants in China and they were rather successful. The experiences and lessons of immunization for migrant population in China might be helpful for other developing countries with a large number of migrant population.

Land and Resource Management Issues Relevant to Deploying In-Situ Thermal Technologies

Energy Technology Data Exchange (ETDEWEB)

Keiter, Robert [Univ. of Utah, Salt Lake City, UT (United States); Ruple, John [Univ. of Utah, Salt Lake City, UT (United States); Tanana, Heather [Univ. of Utah, Salt Lake City, UT (United States); Kline, Michelle [Univ. of Utah, Salt Lake City, UT (United States)

2011-01-01

Utah is home to oil shale resources containing roughly 1.3 trillion barrels of oil equivalent and our nation’s richest oil sands resources. If economically feasible and environmentally responsible means of tapping these resources can be developed, these resources could provide a safe and stable domestic energy source for decades to come. In Utah, oil shale and oil sands resources underlay a patchwork of federal, state, private, and tribal lands that are subject to different regulatory schemes and conflicting management objectives. Evaluating the development potential of Utah’s oil shale and oil sands resources requires an understanding of jurisdictional issues and the challenges they present to deployment and efficient utilization of emerging technologies. The jurisdictional patchwork and divergent management requirements inhibit efficient, economic, and environmentally sustainable development. This report examines these barriers to resource development, methods of obtaining access to landlocked resources, and options for consolidating resource ownership. This report also examines recent legislative efforts to wrest control of western public lands from the federal government. If successful, these efforts could dramatically reshape resource control and access, though these efforts appear to fall far short of their stated goals. The unintended consequences of adversarial approaches to obtaining resource access may outweigh their benefits, hardening positions and increasing tensions to the detriment of overall coordination between resource managers. Federal land exchanges represent a more efficient and mutually beneficial means of consolidating management control and improving management efficiency. Independent of exchange proposals, resource managers must improve coordination, moving beyond mere consultation with neighboring landowners and sister agencies to coordinating actions with them.

Skin Immunization Obviates Alcohol-Related Immune Dysfunction

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Rhonda M. Brand

2015-11-01

Full Text Available Alcoholics suffer from immune dysfunction that can impede vaccine efficacy. If ethanol (EtOH-induced immune impairment is in part a result of direct exposure of immune cells to EtOH, then reduced levels of exposure could result in less immune dysfunction. As alcohol ingestion results in lower alcohol levels in skin than blood, we hypothesized that the skin immune network may be relatively preserved, enabling skin-targeted immunizations to obviate the immune inhibitory effects of alcohol consumption on conventional vaccines. We employed the two most common chronic EtOH mouse feeding models, the liver-damaging Lieber-DeCarli (LD and liver-sparing Meadows-Cook (MC diets, to examine the roles of EtOH and/or EtOH-induced liver dysfunction on alcohol related immunosuppression. Pair-fed mice were immunized against the model antigen ovalbumin (OVA by DNA immunization or against flu by administering the protein-based influenza vaccine either systemically (IV, IM, directly to liver (hydrodynamic, or cutaneously (biolistic, ID. We measured resulting tissue EtOH levels, liver stress, regulatory T cell (Treg, and myeloid-derived suppressor cell (MDSC populations. We compared immune responsiveness by measuring delayed-type hypersensitivity (DTH, antigen-specific cytotoxic T lymphocyte (CTL, and antibody induction as a function of delivery route and feeding model. We found that, as expected, and independent of the feeding model, EtOH ingestion inhibits DTH, CTL lysis, and antigen-specific total IgG induced by traditional systemic vaccines. On the other hand, skin-targeted vaccines were equally immunogenic in alcohol-exposed and non-exposed subjects, suggesting that cutaneous immunization may result in more efficacious vaccination in alcohol-ingesting subjects.

The role of the immune system in neurodegenerative disorders: Adaptive or maladaptive?

Science.gov (United States)

Doty, Kevin R; Guillot-Sestier, Marie-Victoire; Town, Terrence

2015-08-18

Neurodegenerative diseases share common features, including catastrophic neuronal loss that leads to cognitive or motor dysfunction. Neuronal injury occurs in an inflammatory milieu that is populated by resident and sometimes, infiltrating, immune cells - all of which participate in a complex interplay between secreted inflammatory modulators and activated immune cell surface receptors. The importance of these immunomodulators is highlighted by the number of immune factors that have been associated with increased risk of neurodegeneration in recent genome-wide association studies. One of the more difficult tasks for designing therapeutic strategies for immune modulation against neurodegenerative diseases is teasing apart beneficial from harmful signals. In this regard, learning more about the immune components of these diseases has yielded common themes. These unifying concepts should eventually enable immune-based therapeutics for treatment of Alzheimer׳s and Parkinson׳s diseases and amyotrophic lateral sclerosis. Targeted immune modulation should be possible to temper maladaptive factors, enabling beneficial immune responses in the context of neurodegenerative diseases. This article is part of a Special Issue entitled SI: Neuroimmunology in Health And Disease. Copyright © 2014 Elsevier B.V. All rights reserved.

Maternal immunity enhances systemic recall immune responses upon oral immunization of piglets with F4 fimbriae.

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Nguyen, Ut V; Melkebeek, Vesna; Devriendt, Bert; Goetstouwers, Tiphanie; Van Poucke, Mario; Peelman, Luc; Goddeeris, Bruno M; Cox, Eric

2015-06-23

F4 enterotoxigenic Escherichia coli (ETEC) cause diarrhoea and mortality in piglets leading to severe economic losses. Oral immunization of piglets with F4 fimbriae induces a protective intestinal immune response evidenced by an F4-specific serum and intestinal IgA response. However, successful oral immunization of pigs with F4 fimbriae in the presence of maternal immunity has not been demonstrated yet. In the present study we aimed to evaluate the effect of maternal immunity on the induction of a systemic immune response upon oral immunization of piglets. Whereas F4-specific IgG and IgA could be induced by oral immunization of pigs without maternal antibodies and by intramuscular immunization of pigs with maternal antibodies, no such response was seen in the orally immunized animals with maternal antibodies. Since maternal antibodies can mask an antibody response, we also looked by ELIspot assays for circulating F4-specific antibody secreting cells (ASCs). Enumerating the F4-specific ASCs within the circulating peripheral blood mononuclear cells, and the number of F4-specific IgA ASCs within the circulating IgA(+) B-cells revealed an F4-specific immune response in the orally immunized animals with maternal antibodies. Interestingly, results suggest a more robust IgA booster response by oral immunization of pigs with than without maternal antibodies. These results demonstrate that oral immunization of piglets with F4-specific maternal antibodies is feasible and that these maternal antibodies seem to enhance the secondary systemic immune response. Furthermore, our ELIspot assay on enriched IgA(+) B-cells could be used as a screening procedure to optimize mucosal immunization protocols in pigs with maternal immunity.

Understanding cultural issues in the diabetes self-management behaviors of Korean immigrants.

Science.gov (United States)

Cha, EunSeok; Yang, Kyeongra; Lee, Jia; Min, Jiwon; Kim, Kevin H; Dunbar, Sandra B; Jennings, Bonnie Mowinski

2012-01-01

The purpose of this study was to explore potential factors affecting the self-management behaviors of Korean immigrants with type 2 diabetes mellitus (KIT2Ds). A qualitative descriptive design guided this study. Semistructured interviews lasting 45 to 60 minutes were conducted with 20 KIT2Ds in the participants' preferred language; in all cases, this was Korean. Each interview was audiotaped, transcribed, and analyzed using conventional content analysis. Data analysis was performed in two steps. The data written in Korean were initially analyzed by 3 bilingual researchers. A qualitative researcher then participated in the analysis to refine the findings for presentation to an English-speaking audience while staying true to the data and preserving the nuanced Korean meanings. The mean age of the sample was 64. 5 ± 11.6 years (9 men and 11 women). The mean years of staying in the United States and age at diabetes mellitus diagnosis were 23.6 ± 9.7 years and 52.5 ± 12.3 years, respectively. Three major ideas were identified: (1) issues on treatment regimen related to medications and diet, (2) resources that helped or hindered ability to manage diabetes, and (3) the physician-patient relationship. Important cultural nuances need to be addressed to better prepare KIT2Ds to manage their diabetes more effectively. A culture-specific program should extend beyond a diabetes self-management education delivered in Korean language. Rather, content and education methods need to consider acculturation effects on diabetes management behaviors.

Pathways to a Sustainable Future: A Curriculum Guide for Maine Schools Exploring Waste Management Issues.

Science.gov (United States)

Chewonki Foundation, Wiscasset, ME.

This action guide is designed to help students and teachers become aware of the concepts and issues of waste management, and to motivate them to action in the classroom, school, home, and community. The guide emphasizes interdisciplinary activities that concentrate on the process of problem solving. Activities are identified by appropriate grade…

Configuration management issues and objectives for a real-time research flight test support facility

Science.gov (United States)

Yergensen, Stephen; Rhea, Donald C.

1988-01-01

Presented are some of the critical issues and objectives pertaining to configuration management for the NASA Western Aeronautical Test Range (WATR) of Ames Research Center. The primary mission of the WATR is to provide a capability for the conduct of aeronautical research flight test through real-time processing and display, tracking, and communications systems. In providing this capability, the WATR must maintain and enforce a configuration management plan which is independent of, but complimentary to, various research flight test project configuration management systems. A primary WATR objective is the continued development of generic research flight test project support capability, wherein the reliability of WATR support provided to all project users is a constant priority. Therefore, the processing of configuration change requests for specific research flight test project requirements must be evaluated within a perspective that maintains this primary objective.

A Quebec survey of issues in cancer pain management.

Science.gov (United States)

MacDonald, Neil; Ayoub, Joseph; Farley, Justine; Foucault, Claudette; Lesage, Pauline; Mayo, Nancy

2002-01-01

We report the results of a cancer pain survey mailed to Quebec hematologist-oncologists and palliative care physicians in 1999. The survey was designed to sample views on the current status of pain management and on obstacles to the provision of adequate pain relief for patients. The survey, formulated by an ethics network centered at the Clinical Research Institute of Montreal, was distributed to all members of the Association of Hematologist-Oncologists of Quebec and to all physician members of the Quebec Palliative Care Association. Responses were obtained from 138 Palliative Care Association members (response rate 61%) and 76 hematologist-oncologists (response rate 45%). Major obstacles reported included inadequate assessment of both contributory psychosocial issues and severity of pain, patient reluctance to take opioids, and inadequate access to non-drug techniques for pain relief. Access to opioids was not regarded as a problem. Both groups felt generally competent in their ability to manage various aspects of cancer pain therapy. They gave little credit to their formal medical school or residency training. Fifty-six percent of the palliative care group and 57% of the hemato-oncologists rated their medical school experience as only "poor" or "fair" on a 4-point scale. Residency ratings were modestly better. We conclude that medical faculties should assign a high priority to teaching health professionals patient assessment techniques. Simple symptom assessment scales should be routinely used in oncology/palliative care practice. Medical school training in pain management is not highly regarded and should be enhanced. We also note that, based on response to the scenario of a patient presenting with severe pain, many physicians, while feeling competent in the use of opioids, may be overly conservative in their initial use.

IJIMAI Editor's Note - Vol. 3 Issue 3

Directory of Open Access Journals (Sweden)

Carlos Enrique Montenegro-Marin

2015-06-01

Full Text Available The research works presented in this issue are based on various topics of interest, among which are included: 3D Interface, Information Extraction, Artificial immune system, Security in Cloud Computing, Genetic Algorithm, Activity recognition, 3D Render Distribution, Software visualization, Event Perception, New Programming Language, Distributed computing, MOOC environments, etc.

PLCG2-associatiated antibody deficiency immune dysregulation (PLAID)

Science.gov (United States)

... not been identified. Mutations in other genes that regulate immune activity along with PLCG2 are likely responsible, ... Application Paylines & Funding Paylines Paylines by Fiscal Year Financial Management Plan Budget Data Comparisons Background on Planning ...

For better or worse: Immune system involvement in Alzheimer's Disease

Directory of Open Access Journals (Sweden)

Emma L. Walton

2018-02-01

Full Text Available In this issue of the Biomedical Journal, we explore the key role of the immune system in the development of Alzheimer's disease. We also learn more about the link between two disorders related to metabolic imbalances, with findings that could help to inform future screening programs. Finally, we would like to highlight some big news for our journal: the Biomedical Journal will be indexed in the Science Citation Index and receive its first official impact factor from this year. Keywords: Alzheimer's disease, Tau, Immune responses, Subclinical hypothyroidism, Metabolic disease

Waste management regulatory compliance issues related to D ampersand D activities at Oak Ridge National Laboratory (ORNL)

International Nuclear Information System (INIS)

Hitch, J.P.; Arnold, S.E.; Burwinkle, T.; Daugherty, D.

1994-01-01

The waste management activities at ORNL related to the decontamination and decommissioning (D ampersand D) of radioactively contaminated buildings are divided into four categories: Operational facilities, inactive or surplus facilities, future facilities planning, and D ampersand D activities. This paper only discusses regulatory issues related to inactive or surplus facilities. Additionally, rather than attempting to address all resulting waste streams and related regulations, this paper highlights only a few of the ORNL waste streams that present key regulatory issues

Issues and decisions for nuclear power plant management after fuel damage events

International Nuclear Information System (INIS)

1997-04-01

Experience has shown that the on-site activities following an incident that results in severely damaged fuel at a nuclear power plant required extraordinary effort. Even in cases that are not extreme but in which fuel damage is greater than mentioned in the specifications for operation, the recovery will require extensive work. This publication includes information from several projects at the IAEA since 1989 that have resulted in a Technical Report, a TECDOC and a Workshop. While the initial purpose of the projects was focused on providing technical information transfer to the experts engaged in recovery work at the damaged unit of Chernobyl NPP, the results have led to a general approach to managing events in which there is substantial fuel damage. This TECDOC summarizes the work to focus on management issues that may be encountered in any such event whether small or large. 11 refs, 2 figs, 5 tabs

Management of graphite material: a key issue for High Temperature Gas Reactor system (HTGR)

International Nuclear Information System (INIS)

Bourdeloie, C.; Marimbeau, P.; Robin, J.C.; Cellier, F.

2005-01-01

Graphite material is used in nuclear High Temperature Gas-cooled Reactors (HTGR, Fig.1) as moderator, thermal absorber and also as structural components of the core (Fig.2). This type of reactor was selected by the Generation IV forum as a potential high temperature provider for supplying hydrogen production plants and is under development in France in the frame of the AREVA ANTARES program. In order to select graphite grades to be used in these future reactors, the requirements for mechanical, thermal, physical-chemical properties must match the internal environment of the nuclear core, especially with regard to irradiation effect. Another important aspect that must be addressed early in design is the waste issue. Indeed, it is necessary to reduce the amount of nuclear waste produced by operation of the reactor during its lifetime. Preliminary assessment of the nuclear waste output for an ANTARES type 280 MWe HTGR over 60 year-lifetime gives an estimated 6000 m 3 of activated graphite waste. Thus, reducing the graphite waste production is an important issue for any HTGR system. First, this paper presents a preliminary inventory of graphite waste fluxes coming from a HTGR, in mass and volume, with magnitudes of radiological activities based on activation calculations of graphite during its stay in the core of the reactor. Normalized data corresponding to an output of 1 GWe.year electricity allows comparison of the waste production with other nuclear reactor systems. Second, possible routes to manage irradiated graphite waste are addressed in both the context of French nuclear waste management rules and by comparison to other national regulations. Routes for graphite waste disposal studied in different countries (concerning existing irradiated graphite waste) will be discussed with regard to new issues of large graphite waste from HTGR. Alternative or complementary solutions aiming at lowering volume of graphite waste to be managed will be presented. For example

Modern approaches for management of the refractory immune thrombocytopenia in pregnancy

Directory of Open Access Journals (Sweden)

Davydova Iu.

2017-01-01

Full Text Available Background. Thrombocytopenia per se is one of the hematological diseases, which demands the repeated thrombocytes infusion. The last tendencies in the management of this disease show the enhanced amount of the necessary thrombocytes doses for treatment and the worldwide trend for the declining of donors. Considerably to these facts the new approaches for the thrombocytopenia treatment have been organized within last two decades. One of them is the finding of the safe, appropriate and effective growth factor for platelets, which could significantly improve the level of thrombocytes. The article describes the case of refractory ITP management in pregnancy. ITP diagnosed at 26 weeks of gestation, the platelet number at the time of diagnostics 20000. The other bone marrow disorders excluded by bone marrow biopsy. The in-patient of the High Risk Pregnancy Department (Obstetric Issues of the Extragenital Pathology from the 28 weeks of pregnancy. Modern approaches for treatment of ITP was describe in the article. Pregnant received therapy according to the latest guidelines. Delivery in term of 33–34 weeks. Integrated treatment of thrombocytopenia. Conclusions. The refractory ITP is a rare disease and could be occasionally seen during pregnancy, but the hemorrhagic complications could be extremely harmful for both mother and child and demand the preterm pregnancy termination. The management of refractory ITP during pregnancy should be performed according to the International recommendations for the thrombocytopenia treatment with all the reserve of the medications. The positive result of the ITP management and perinatal and obstetric outcomes has been achieved through the use of the entire arsenal of drugs, correct tactics of delivery with hemorrhage prevention be using the 4 T strategy and the adequate doses of the tranexamic acid (sangera and rhTPO (Emaplug (Yuriya-Farm, Ukraine. It was the first implementation of the subcutaneous rhTPO in

A system dynamic modeling approach for evaluating municipal solid waste generation, landfill capacity and related cost management issues

International Nuclear Information System (INIS)

Kollikkathara, Naushad; Feng Huan; Yu Danlin

2010-01-01

As planning for sustainable municipal solid waste management has to address several inter-connected issues such as landfill capacity, environmental impacts and financial expenditure, it becomes increasingly necessary to understand the dynamic nature of their interactions. A system dynamics approach designed here attempts to address some of these issues by fitting a model framework for Newark urban region in the US, and running a forecast simulation. The dynamic system developed in this study incorporates the complexity of the waste generation and management process to some extent which is achieved through a combination of simpler sub-processes that are linked together to form a whole. The impact of decision options on the generation of waste in the city, on the remaining landfill capacity of the state, and on the economic cost or benefit actualized by different waste processing options are explored through this approach, providing valuable insights into the urban waste-management process.

Perception of Childhood Immunization among Mothers of Under ...

African Journals Online (AJOL)

global immunization rates were at 83%. Increased knowledge ... Chain and Logistics systems are aging and often ... of better cold chain and supply logistic systems and promoting ... clearance was obtained from the management of St. Charles ...

Impacts of Low Temperature on the Teleost Immune System

Directory of Open Access Journals (Sweden)

Quinn H. Abram

2017-11-01

Full Text Available As poikilothermic vertebrates, fish can experience changes in water temperature, and hence body temperature, as a result of seasonal changes, migration, or efflux of large quantities of effluent into a body of water. Temperature shifts outside of the optimal temperature range for an individual fish species can have negative impacts on the physiology of the animal, including the immune system. As a result, acute or chronic exposure to suboptimal temperatures can impair an organisms’ ability to defend against pathogens and thus compromise the overall health of the animal. This review focuses on the advances made towards understanding the impacts of suboptimal temperature on the soluble and cellular mediators of the innate and adaptive immune systems of fishes. Although cold stress can result in varying effects in different fish species, acute and chronic suboptimal temperature exposure generally yield suppressive effects, particularly on adaptive immunity. Knowledge of the effects of environmental temperature on fish species is critical for both the optimal management of wild species and the best management practices for aquaculture species.

Issues and Tensions in Island Heritage Management: A Case Study of Motuihe Island, New Zealand

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David Bade

2010-05-01

Full Text Available This paper draws on a New Zealand case study, Motuihe Island, to examine the challenges of conserving cultural heritage in places renowned for natural heritage values. In keeping with the broader trend toward the ecological restoration of islands close to Auckland, Motuihe Island is undergoing conversion into an ecosystem of native flora and fauna. Issues and tensions relating to the management of natural and cultural heritage will be discussed and influencing aspects investigated: the nature/culture dualism, the effect of New Zealand’s history and identity, and the influence of islandness on heritage management.

Biological Immune System Applications on Mobile Robot for Disabled People

Directory of Open Access Journals (Sweden)

Songmin Jia

2014-01-01

Full Text Available To improve the service quality of service robots for the disabled, immune system is applied on robot for its advantages such as diversity, dynamic, parallel management, self-organization, and self-adaptation. According to the immune system theory, local environment condition sensed by robot is considered an antigen while robot is regarded as B-cell and possible node as antibody, respectively. Antibody-antigen affinity is employed to choose the optimal possible node to ensure the service robot can pass through the optimal path. The paper details the immune system applications on service robot and gives experimental results.

Special issue on ageing management and long term operation of light water reactors

International Nuclear Information System (INIS)

Kashima, Koichi; Kanno, Masanori; Kimura, Itsurou

2008-01-01

Ageing management and long term operation of light water reactors became important in Japan and relevant research on physical and materials ageing has been carried out among organizations of government, academia and industry and establishment of technical standards and guideline based on the results is under way. The Japan Energy Policy Institute (JEPI) issued a special number discussing this theme, which consisted of ten reports of experts describing these activities. Main topics were ageing evaluation of reactor components due to neutron irradiation embrittlement and stress corrosion cracking, regulatory evaluation of deteriorations due to ageing with technical information basis, technology development in the area of inspection/monitoring, ageing evaluation and preventive maintenance/repairs, nuclear power plant life management of electric utilities, and advancement of reactor maintenance and inspection. (T. Tanaka)

Unraveling the relationship between microbial translocation and systemic immune activation in HIV infection

Science.gov (United States)

Shan, Liang; Siliciano, Robert F.

2014-01-01

Chronic immune activation is a key factor in HIV-1 disease progression. The translocation of microbial products from the intestinal lumen into the systemic circulation occurs during HIV-1 infection and is associated closely with immune activation; however, it has not been determined conclusively whether microbial translocation drives immune activation or occurs as a consequence of HIV-1 infection. In an important study in this issue of the JCI, Kristoff and colleagues describe the role of microbial translocation in producing immune activation in an animal model of HIV-1 infection, SIV infection of pigtailed macaques. Blocking translocation of intestinal bacterial LPS into the circulation dramatically reduced T cell activation and proliferation, production of proinflammatory cytokines, and plasma SIV RNA levels. This study directly demonstrates that microbial translocation promotes the systemic immune activation associated with HIV-1/SIV infection. PMID:24837427

Small and medium sized enterprises and sustainability: managers' values and engagement with environmental and climate change issues.

OpenAIRE

Schaefer, Anja; Williams, Sarah

2013-01-01

This article reports on an in-depth, qualitative study into the pro-environmental engagement of small businesses in the east of England, with respect to climate change in particular. Managers of environmentally pro-active small businesses were asked about the proenvironmental measures they had implemented in their firms, their motivations for doing so, and their understanding of climate change. The managers in this study had a relatively good understanding of environmental issues in general a...

Effectively managing public concerns about immunization safety

Directory of Open Access Journals (Sweden)

2002-01-01

Full Text Available Los beneficios de la vacunación frente a las enfermedades prevenibles de este modo son muy superiores a sus mínimos riesgos. Con el fin de mantener o fortalecer los programas nacionales de vacunación, los trabajadores de todos los niveles de la salud pública deberían recibir formación sobre los temas relacionados con la vacunación y estar preparados para responder a las dudas planteadas por el público. Una respuesta rápida y franca a los temores del público acerca de las vacunas podría garantizar la integridad de los programas de vacunación en todo el continente americano, según el documento "Directrices para enfrentarse a los temores sobre la seguridad de las vacunaciones" (Guidelines for Managing Immunization Safety Concerns, elaborado por la División de Vacunas e Inmunización de la Organización Panamericana de la Salud (OPS y resumido aquí. Todo acontecimiento médico que se considere posiblemente relacionado con una vacuna debe ser investigado en el ámbito local. Si su distribución temporal y los síntomas respaldan la sospecha de que pueda estar relacionado con una vacuna, se debe iniciar una investigación más formal y, una vez finalizada, el acontecimiento debe ser clasificado en una de las cuatro categorías siguientes: 1 relacionado con el programa, 2 relacionado con la vacuna, 3 no relacionado, o 4 desconocido (investigación no concluyente. Dependiendo de la categoría a la que haya sido asignado el acontecimiento, las acciones posteriores pueden consistir en tranquilizar a los padres, a los cuidadores y a otros adultos; comunicarse con el público y con otros trabajadores de la salud; instaurar tratamiento; corregir los errores del programa, como pueden ser la manipulación de la vacuna, su almacenamiento, su administration o los problemas relacionados con la jeringuilla; comentar con los fabricantes problemas relacionados con la calidad y eficacia de la vacuna; retirar la vacuna del mercado, o iniciar nuevas

Pending issues for severe accident management in Wolsong plants

International Nuclear Information System (INIS)

Song, Y.M.; Kim, D.H.; Park, S.Y.

2015-01-01

While the fraction of electric power supplied from a PHWR is more than 10% in Korea, the establishment of PHWR safety enhancement based on the SAM (Severe Accident Management) technology is still weak. The final approval on the extended operation and a stress test of Wolsong-1 were made under the condition that SAM is to be enhanced. Under this situation, the current research at KAERI of Korea has a vision to strengthen the unique value of a PHWR by resolving the pending SAM issues devaluating the PHWRs’ original value. Research activities in this area will be presented. This presentation will include: The operating strategy of CFVS (Containment Filtered Vent System) for Wolsong in which vent size and closure pressure are treated because some peak spikes (at failure times of calandria and calandria vault) are difficult to be controlled; Reactor Building failure pressure at which failure probability is treated for different modes such as global and leak failures; the adequacy of DCRV (Degasser Condenser tank Relief Valve) steam relief capacity with severe SGTR source term, and Hydrogen generation and control issue which is specific to CANDU. Furthermore, current SAM guidance has a lack of information on accident diagnostic and prognostic analyses, which is difficult for the TSC (Technical Service Center) emergency staff members to deal with under real accident conditions. Thus, prototypic technologies (such as an accident inferring engine and simulator) together with SAM updates are being developed as key elements to SAM supporting tools called SAMEX-CANDU

Research Article Special Issue

African Journals Online (AJOL)

pc

2018-04-16

Apr 16, 2018 ... The dimensions to business process strategy factors are .... Investigation pains directed at further exploring these issues are very ... relationship management, material flow management, corporate culture in SMEs' Customer.

NDA generic research programme for higher activity waste management issues - 16390

International Nuclear Information System (INIS)

McKinney, James; Brownridge, Melanie

2009-01-01

NDA has a responsibility to ensure decommissioning activities are sufficiently technically underpinned and appropriate Research and Development (Rand D) is carried out. The NDA funds research and development (R and D) indirectly via the Site Licence Companies (SLCs) or directly. The main component of directly funded R and D is the NDA Direct Research Portfolio (DRP). The DRP is split into four framework areas: - University Interactions; - Waste Processing; - Material Characterisation; - Actinide and Strategic Nuclear Materials. These four framework areas were competed through an Official Journal of European Union (OJEU) process in 2008. Although all four areas involve waste management, Waste Processing and Material Characterisation specifically deal with Higher Activity Waste (HAW) waste management issues. The Waste Processing area was awarded to three groups: (i) National Nuclear Laboratory (NNL), (ii) Consortium led by Hyder Consulting Ltd, and (iii) Consortium led by UKAEA Ltd. The Material Characterisation area was awarded to three groups: (i) NNL, (ii) Serco, and (iii) Consortium led by UKAEA Ltd. The initial work in Waste Processing and Material Characterisation was centered on establishing a forward research programme to address the generic needs of the UK civil nuclear industry and the NDA strategic drivers for waste management and land quality. This has been achieved by the four main framework contractors from the Waste Processing and Materials Characterisation areas working together with the NDA to identify the key research themes and begin the development of the NDA's HAW Management Research Programme. The process also involves active engagement with both industry and regulators via the Nuclear Waste Research Forum (NWRF). The NDA's HAW Management Research Programme includes a number of themes: - Optimisation of Interim Store Operation and Design; - Alternative Waste Encapsulants; - Waste Package Integrity; - Alternative Waste treatment methods

Imbalanced immune homeostasis in immune thrombocytopenia.

Science.gov (United States)

Yazdanbakhsh, Karina

2016-04-01

Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder resulting from low platelet counts caused by inadequate production as well as increased destruction by autoimmune mechanisms. As with other autoimmune disorders, chronic ITP is characterized by perturbations of immune homeostasis with hyperactivated effector cells as well as defective regulatory arm of the adaptive immune system, which will be reviewed here. Interestingly, some ITP treatments are associated with restoring the regulatory imbalance, although it remains unclear whether the immune system is redirected to a state of tolerance once treatment is discontinued. Understanding the mechanisms that result in breakdown of immune homeostasis in ITP will help to identify novel pathways for restoring tolerance and inhibiting effector cell responses. This information can then be translated into developing therapies for averting autoimmunity not only in ITP but also many autoimmune disorders. Copyright © 2016 Elsevier Inc. All rights reserved.

Immunizing Children

Directory of Open Access Journals (Sweden)

Geraldine Jody Macdonald

2014-11-01

Full Text Available This article addresses the complex contexts within which Canadian health professionals engage in immunizing children and focuses on the Canadian practice guidelines and current scientific evidence that direct Canadian health professional competencies. The article begins by presenting two current global vaccine initiatives and links these to immunization in Canada. A selected literature review identifies current best immunization practices. With the purpose of promoting quality improvement, three key Canadian immunization competencies for health professional are highlighted: communication with parents, including those who are experiencing vaccine hesitancy; administration of immunizing agents; and documentation of immunizations. Health professionals are encouraged to reflect on immunization competencies and ensure evidence-based practices underpin vaccine delivery in their primary care settings.

Korean interim storage issues and R and D activities on spent fuel management

International Nuclear Information System (INIS)

Ji Sup Yoon; Seung-Gy Ro; Hyun-Soo Park

1999-01-01

Korea has witnessed over a decade of vicissitudes in the issue of radioactive waste management due mainly to the problem of site acquisition. As the major mission of the nation at radioactive waste management programme was to provide a center for disposal of low-level radwaste and for interim storage of spent nuclear fuel from nuclear power plants, the question of site securing has had a big impact on the implement action of overall programme. The site problem has resulted in, as an aftermath, restructuring of the overall programme for radioactive waste management. Missions of NEMAC (Nuclear Environment Management Center), originally established as a subsidiary of Korea Atomic Energy Research Institute (KAERI), for the national programme was dissolved as of the end of last year. Beginning of this year, a new entity NETEC (Nuclear Environment Technology Center) as a subsidiary of KEPCO (Korea Electric Power Co.) has taken over major tasks of the past NEMAC, while the R and D work associated with the past task of NEMAC is transferred back to KAERI. This paper gives a review on the past background which has driven the radioactive waste management in Korea to the current state of the affairs, with special emphasis on R and D activities associated with spent nuclear fuel transportation, handling, and storage. (author)

Immune disorders in anorexia.

Science.gov (United States)

Słotwińska, Sylwia Małgorzata; Słotwiński, Robert

2017-01-01

Anorexia nervosa is a disease involving eating disorders. It mainly affects young people, especially teenage women. The disease is often latent and occurs in many sub-clinical and partial forms. Approximately from 0.3% to 1% of the population suffers from anorexia. It has been shown that patients with anorexia develop neurotransmitter-related disorders, leading to uncontrolled changes in the immune and endocrine systems. Interactions between cytokines, neuropeptides, and neurotransmitters play an important role in disease development. Significant malnutrition induces disorders and alterations in T-cell populations. The cellular response in patients with anorexia nervosa has been shown to be normal, although opinions on this issue are controversial. Laboratory studies on neutrophils in anorexia patients showed decreased adhesion and reduced bactericidal and cell activities. Despite such unfavourable results, patients with anorexia are resistant to infections, which are very rare in this group. Glutamine improves the performance of the human immune system. The administration of glutamine to anorexia patients, as a supplement to parenteral nutrition, has resulted in significant improvements in immune system parameters. The results of previous studies on the causes and risk factors in the development of anorexia nervosa are still ambiguous. One can hope that the differences and similarities between patients with anorexia nervosa and those with other forms of protein-calorie malnutrition may be helpful in determining the relationship between nutritional status and body defences and susceptibility to infection, and can help to broaden the knowledge about the aetiopathogenesis of anorexia nervosa.

The Lung Immune Response to Nontypeable Haemophilus influenzae (Lung Immunity to NTHi

Directory of Open Access Journals (Sweden)

Paul T. King

2015-01-01

Full Text Available Haemophilus influenzae is divided into typeable or nontypeable strains based on the presence or absence of a polysaccharide capsule. The typeable strains (such as type b are an important cause of systemic infection, whilst the nontypeable strains (designated as NTHi are predominantly respiratory mucosal pathogens. NTHi is present as part of the normal microbiome in the nasopharynx, from where it may spread down to the lower respiratory tract. In this context it is no longer a commensal and becomes an important respiratory pathogen associated with a range of common conditions including bronchitis, bronchiectasis, pneumonia, and particularly chronic obstructive pulmonary disease. NTHi induces a strong inflammatory response in the respiratory tract with activation of immune responses, which often fail to clear the bacteria from the lung. This results in recurrent/persistent infection and chronic inflammation with consequent lung pathology. This review will summarise the current literature about the lung immune response to nontypeable Haemophilus influenzae, a topic that has important implications for patient management.

Monitoring asthma in childhood: management-related issues

Directory of Open Access Journals (Sweden)

Bart L. Rottier

2015-06-01

Full Text Available Management-related issues are an important aspect of monitoring asthma in children in clinical practice. This review summarises the literature on practical aspects of monitoring including adherence to treatment, inhalation technique, ongoing exposure to allergens and irritants, comorbid conditions and side-effects of treatment, as agreed by the European Respiratory Society Task Force on Monitoring Asthma in Childhood. The evidence indicates that it is important to discuss adherence to treatment in a non-confrontational way at every clinic visit, and take into account a patient's illness and medication beliefs. All task force members teach inhalation techniques at least twice when introducing a new inhalation device and then at least annually. Exposure to second-hand tobacco smoke, combustion-derived air pollutants, house dust mites, fungal spores, pollens and pet dander deserve regular attention during follow-up according to most task force members. In addition, allergic rhinitis should be considered as a cause for poor asthma control. Task force members do not screen for gastro-oesophageal reflux and food allergy. Height and weight are generally measured at least annually to identify individuals who are susceptible to adrenal suppression and to calculate body mass index, even though causality between obesity and asthma has not been established. In cases of poor asthma control, before stepping up treatment the above aspects of monitoring deserve closer attention.

Managing radioactive waste issues and misunderstandings (radiation realities, energy comparison, waste strategies)

International Nuclear Information System (INIS)

Rosen, M.

2001-01-01

The technical specialist is confident that radioactive waste can be safely managed, but many in the public remain totally unconvinced. There are issues and deep-seated misunderstandings that drive public doubts. Currently, a growing concern with pollution from other industrial waste is enabling radioactive waste issues to be debated in a wider context that allows comparisons with other potentially hazardous waste, particularly from energy generation sources. Health effects and time period issues are not unique to radioactive waste. This paper concentrates on 3 topics. The first concerns radiation health effects where the real realities of radiation are covered. The large misunderstandings that exist about radiation and its health effects have led to an almost zero health impact regulatory policy. A policy which must be more fully understood and dealt with. The second topic deals with a few revealing comparisons about the various energy generation systems. Nuclear power's 10 thousand fold lower fuel requirements, compared with a comparable fossil fuelled plant, is a dominating factor decisively minimising environmental impacts. The third topic examines waste disposal strategies. Extraordinarily small radioactive waste quantities permit a confinement strategy for disposal as opposed to the more common dispersion strategy for most toxic waste. The small quantities coupled with radioactive decay, contrary to the public perception, make any potential hazard from both low and high level radioactive waste exceedingly small. (author)

Issues facing the management of radioactively contaminated lead within the DOE system

International Nuclear Information System (INIS)

Gilmore, M.C.; Kent, S.H.

1993-01-01

The purpose of this paper is to discuss and evaluate the issues that managing and operating contractors in the US DOE system should consider that are associated with management of radioactively contaminated elemental lead. There are many instances where DOE contaminated lead fall within Resource Conservation and Recovery Act (RCRA) regulation. In light of the Federal Facilities Compliance Act (FFCA), it is becoming increasingly important for additional regulatory options to be explored in order to facilitate proper treatment, storage and disposal of RCRA regulated lead. Various DOE facilities have initiated processes to reuse or recycle contaminated lead. Technologies such as melt-refining, surface blasting, and electromigration are being explored. One or more of these technologies may be the key to reducing contaminated lead inventories in the DOE system. Many DOE facilities are finding that these efforts need to have stringent regulatory evaluation since some alternatives have proven to be environmentally desirable but not economically feasible

Titanium dioxide nanoparticles stimulate sea urchin immune cell phagocytic activity involving TLR/p38 MAPK-mediated signalling pathway

Science.gov (United States)

Pinsino, Annalisa; Russo, Roberta; Bonaventura, Rosa; Brunelli, Andrea; Marcomini, Antonio; Matranga, Valeria

2015-01-01

Titanium dioxide nanoparticles (TiO2NPs) are one of the most widespread-engineered particles in use for drug delivery, cosmetics, and electronics. However, TiO2NP safety is still an open issue, even for ethical reasons. In this work, we investigated the sea urchin Paracentrotus lividus immune cell model as a proxy to humans, to elucidate a potential pathway that can be involved in the persistent TiO2NP-immune cell interaction in vivo. Morphology, phagocytic ability, changes in activation/inactivation of a few mitogen-activated protein kinases (p38 MAPK, ERK), variations of other key proteins triggering immune response (Toll-like receptor 4-like, Heat shock protein 70, Interleukin-6) and modifications in the expression of related immune response genes were investigated. Our findings indicate that TiO2NPs influence the signal transduction downstream targets of p38 MAPK without eliciting an inflammatory response or other harmful effects on biological functions. We strongly recommend sea urchin immune cells as a new powerful model for nano-safety/nano-toxicity investigations without the ethical normative issue. PMID:26412401

The management, privacy and medico-legal issues of electronic CPAP data in Australia and New Zealand: Electronic CPAP data management in Australia and New Zealand.

Science.gov (United States)

Swieca, John; Hamilton, Garun S; Meaklim, Hailey

2017-08-01

Continuous Positive Airway Pressure (CPAP) is considered to be the gold standard treatment for obstructive sleep apnoea (OSA). CPAP monitoring systems allow tracking of patient CPAP adherence and treatment efficacy, by measuring residual sleep-disordered breathing, hours of CPAP use, and mask leak etc. The American Thoracic Society (ATS) published a position paper in 2013 highlighting issues of interpreting CPAP data such as a lack of consistency between CPAP manufacturers data algorithms, legal implications of CPAP data and implications for CPAP adherence. This paper extends on this work by investigating these issues in an Australasian context. A review of current literature on CPAP monitoring systems, privacy and security of CPAP data for major Australasian CPAP providers, and CPAP adherence was undertaken. A legal review was also commissioned for issues related to privacy and security of CPAP data. CPAP manufacturers' utilize different algorithms for respiratory event detection and clinicians need to be aware the implications for interpreting CPAP data. Australasian CPAP manufacturers have created security/privacy policies with the intent to follow relevant legislation to protect patients' CPAP data, however they do need to be constantly reviewed and updated to avoid data breaches and changes to agreements. No guarantees can be provided by the Australasian Sleep Association on CPAP manufacturers' compliance with these policies and there is the potential for some degree of liability for physicians and CPAP providers associated with CPAP data. Lastly, providing patients with feedback on their CPAP usage and OSA management appears to have positive influence CPAP adherence. CPAP data provides many opportunities to increase OSA patient care and to help patients self-manage this chronic condition. However, issues relating to lack of standardization of CPAP parameters, privacy, security, and legal implications will need to be managed in this changing technologic and

Pilot projects and nation-wide immunization in India.

Science.gov (United States)

Haxton, D

1984-01-01

These studies identify possibilities for expanding immunization coverage in India and show that there have been positive experiences in going to scale with immunizationation at the district level. Reasons for success are discussed. The promotion of social awareness and participation through all available channels is of central importance. Continuing attention should be directed to vaccine supply and distribution systems, program management and manpower training, especially at the community level. There are many opportunities for extending involvement in immunization efforts and broad-spectrum programs beyond the confines of the health system, and for flexibility in program organization. Planning must incorporate political commitment as well as the provision of adequate financial resources. India launched the Expanded Program on Immunization (EPI) in 1978. 6 diseases are currently on the official schedule for progressive nation-wide immunization: tuberculosis, poliomyelitis, whooping cough, diptheria, tetanus and typhoid. The experiences of 3 efforts in Dewas, in Bidar, (2 rural areas), and in Delhi (an urban area) are covered. Immunization coverage before the intensive efforts did not exceed 30%. Major elements of program organization were: nonhealth sector political and administrative involvement from the state; multisectoral planning committees at different levels; household surveys to identify children to be immunized; training sessions for each category of workers; and strengthening the cold chain. Factors in operational design and implementation include: vaccination posts in the community; selection of acceptable vaccination days; reminders the day before vaccination; collection of children; immunization cards as a device for informing about next round; counteraction of side-effects; follow-up of drop-outs; monitoring for corrective action involving all participants; and formal evaluation by local medical colleges. Intensive immunization in the 3 pilot sites

Supply Chain Management on IBS Implementation in Klang Valley Construction Industry: Challenges and Issues

Science.gov (United States)

Azrizal Fauzi, Mohd; Hasim, Sulaiman; Awang, Anizah; Ridzuan, Ahmad Ruslan Mohd; Nur Yunus, Juzailah

2017-12-01

Industrialized Building System (IBS) is a system where the components of the building are manufactured in a factory and it will be transported to the site to form the structures. The supply chain management (SCM) is a system where the delivery flows of the IBS products from manufacturers to the site. The aim of this research is to identify the major challenges and to analyze the issues on IBS implementation in SCM in Klang Valley from the manufacturers perspective. The methodology used in this paper is based on primary data through questionnaire and interview. Questionnaires were sent to the Manufacturers. It can be concluded that this paper attempts to present more on the challenges and issues that those companies of manufacturers faced during their success journey in finding integration in their supply chain. The main contributions of this paper are integrating all the supply chain integration challenges and issues on IBS. Therefore, these contributions will be helpful for the organization of manufacturers and IBS players that establish the integration in their SCM.

The Performance Of Alternative Interest Rate Risk Measures And Immunization Strategies Under A Heath-Jarrow-Morton Framework

OpenAIRE

Agca, Senay

2002-01-01

The Heath-Jarrow-Morton (HJM) model represents the latest in powerful arbitrage-free technology for modeling the term structure and managing interest rate risk. Yet risk management strategies in the form of immunization portfolios using duration, convexity, and M-square are still widely used in bond portfolio management today. This study addresses the question of how traditional risk measures and immunization strategies perform when the term structure evolves in the HJM manner. Using Monte Ca...

Status of safety issues at licensed power plants: TMI action plan requirements, unresolved safety issues, generic safety issues

International Nuclear Information System (INIS)

1991-12-01

As part of ongoing US Nuclear Regulatory Commission (NRC) efforts to ensure the quality and accountability of safety issue information, a program was established whereby an annual NUREG report would be published on the status of licensee implementation and NRC verification of safety issues in major NRC requirements areas. This information was compiled and reported in three NUREG volumes. Volume 1, published in March 1991, addressed the status of of Three Mile Island (TMI) Action Plan Requirements. Volume 2, published in May 1991, addressed the status of unresolved safety issues (USIs). Volume 3, published in June 1991, addressed the implementation and verification status of generic safety issues (GSIs). This annual NUREG report combines these volumes into a single report and provides updated information as of September 30, 1991. The data contained in these NUREG reports are a product of the NRC's Safety Issues Management System (SIMS) database, which is maintained by the Project Management Staff in the Office of Nuclear Reactor Regulation and by NRC regional personnel. This report is to provide a comprehensive description of the implementation and verification status of TMI Action Plan Requirements, safety issues designated as USIs, and GSIs that have been resolved and involve implementation of an action or actions by licensees. This report makes the information available to other interested parties, including the public. An additional purpose of this NUREG report is to serve as a follow-on to NUREG-0933, ''A Prioritization of Generic Safety Issues,'' which tracks safety issues up until requirements are approved for imposition at licensed plants or until the NRC issues a request for action by licensees

How do physicians immunize their own children? Differences among pediatricians and nonpediatricians.

Science.gov (United States)

Posfay-Barbe, Klara M; Heininger, Ulrich; Aebi, Christoph; Desgrandchamps, Daniel; Vaudaux, Bernard; Siegrist, Claire-Anne

2005-11-01

Immunization has an essential impact on public health worldwide. Numerous studies have shown the efficacy of different vaccines to protect individuals from various diseases. However, some parents choose not to vaccinate their children for reasons such as, among others, doubts regarding their usefulness, concerns over safety or efficacy, etc. Physicians are known to exert a direct influence on immunization rates by answering questions and clarifying misconceptions. Yet, it is unknown how they immunize their own children. We sought to assess how physicians interested in vaccination issues immunized, or would immunize, their own children. An 11-question, Web-based survey with a total of 102 discrete answers was sent to 2070 Swiss physicians in October 2004. All physicians were subscribers to a nonprofit, Web-based expert network (InfoVac, www.infovac.ch) that distributes monthly newsletters and answers question within 2 days on immunization issues. The InfoVac network reaches > 95% of pediatricians in Switzerland but issued yearly. One question compared their immunization practice between their own children and their patients. Sociodemographics, qualifying year, membership in different professional groups, and their type of practice were also requested. Statistics. Standard descriptive statistics were used for sociodemographic characteristics. Univariate statistical analyses were performed for each variable to determine its relationship to the dependent variable, being a pediatrician or nonpediatrician. Logistic-regression analysis was used to calculate the adjusted odds ratios (ORs) and 95% confidence intervals (CIs), controlling for any statistically significant demographic variables that might function as confounders (gender, parenthood, workplace, year of diploma, and type of practice). For all statistical tests, differences were considered significant at P or = 1 child. All physicians reported immunizing children in their practice. Pediatricians were more likely

Immunization and Hedging of Post Retirement Income Annuity Products

Directory of Open Access Journals (Sweden)

Changyu Liu

2017-03-01

Full Text Available Designing post retirement benefits requires access to appropriate investment instruments to manage the interest rate and longevity risks. Post retirement benefits are increasingly taken as a form of income benefit, either as a pension or an annuity. Pension funds and life insurers offer annuities generating long term liabilities linked to longevity. Risk management of life annuity portfolios for interest rate risks is well developed but the incorporation of longevity risk has received limited attention. We develop an immunization approach and a delta-gamma based hedging approach to manage the risks of adverse portfolio surplus using stochastic models for mortality and interest rates. We compare and assess the immunization and hedge effectiveness of fixed-income coupon bonds, annuity bonds, as well as longevity bonds, using simulations of the portfolio surplus for an annuity portfolio and a range of risk measures including value-at-risk. We show how fixed-income annuity bonds can more effectively match cash flows and provide additional hedge effectiveness over coupon bonds. Longevity bonds, including deferred longevity bonds, reduce risk significantly compared to coupon and annuity bonds, reflecting the long duration of the typical life annuity and the exposure to longevity risk. Longevity bonds are shown to be effective in immunizing surplus over short and long horizons. Delta gamma hedging is generally only effective over short horizons. The results of the paper have implications for how providers of post retirement income benefit streams can manage risks in demanding conditions where innovation in investment markets can support new products and increase the product range.

Strategic management and organizational behavior in dental education: reflections on key issues in an environment of change.

Science.gov (United States)

Dunning, David G; Durham, Timothy M; Lange, Brian M; Aksu, Mert N

2009-06-01

With issues such as shrinking revenue, access to care, faculty workloads, and graying faculty, dental schools are faced with difficult challenges that fall to dental school deans to manage. Do dental school deans have the organizational skill sets and ethical frameworks necessary to address the challenges now facing dental schools? The purpose of this article is to pose questions and suggestions regarding some of the key issues in dental colleges today and to stimulate discussion in the dental community about needed changes in dental education.

Florida's salt-marsh management issues: 1991-98.

Science.gov (United States)

Carlson, D B; O'Bryan, P D; Rey, J R

1999-06-01

During the 1990s, Florida has continued to make important strides in managing salt marshes for both mosquito control and natural resource enhancement. The political mechanism for this progress continues to be interagency cooperation through the Florida Coordinating Council on Mosquito Control and its Subcommittee on Managed Marshes (SOMM). Continuing management experience and research has helped refine the most environmentally acceptable source reduction methods, which typically are Rotational Impoundment Management or Open Marsh Water Management. The development of regional marsh management plans for salt marshes within the Indian River Lagoon by the SOMM has helped direct the implementation of the best management practices for these marshes. Controversy occasionally occurs concerning what management technique is most appropriate for individual marshes. The most common disagreement is over the benefits of maintaining an impoundment in an "open" vs. "closed" condition, with the "closed" condition, allowing for summer mosquito control flooding or winter waterfowl management. New federal initiatives influencing salt-marsh management have included the Indian River Lagoon-National Estuary Program and the Pesticide Environmental Stewardship Program. A new Florida initiative is the Florida Department of Environmental Protection's Eco-system Management Program with continuing involvement by the Surface Water Improvement and Management program. A developing mitigation banking program has the potential to benefit marsh management but mosquito control interests may suffer if not handled properly. Larvicides remain as an important salt-marsh integrated pest management tool with the greatest acreage being treated with temephos, followed by Bacillus thuringiensis israelensis and methoprene. However, over the past 14 years, use of biorational larvicides has increased greatly.

Financial sustainability planning for immunization services in Cambodia.

Science.gov (United States)

Soeung, Sann Chan; Grundy, John; Maynard, Jim; Brooks, Alan; Boreland, Marian; Sarak, Duong; Jenkinson, Karl; Biggs, Beverley-Ann

2006-07-01

The expanded programme of immunization was established in Cambodia in 1986. In 2002, 67% of eligible children were immunized, despite significant health sector and macro-economic financial constraints. A financial sustainability planning process for immunization was introduced in 2002, in order to mobilize national and international resources in support of the achievement of child health objectives. The aim of this paper is to outline this process, describe its early impact as an advocacy tool and recommend additional strategies for mobilizing additional resources for health. The methods of financial sustainability planning are described, including the advocacy strategies that were applied. Analysis of financial sustainability planning results indicates rising programme costs associated with new vaccine introduction and new technologies. Despite this, the national programme has demonstrated important early successes in using financial sustainability planning to advocate for increased mobilization of national and international sources of funding for immunization. The national immunization programme nevertheless faces formidable system and financial challenges in the coming years associated with rising costs, potentially diminishing sources of international assistance, and the developing role of sub-national authorities in programme management and financing.

The international emergency management society conference 1997. National and international issues concerning research and applications

International Nuclear Information System (INIS)

Andersen, V.; Hansen, V.

1997-01-01

The International Emergency Management Society (TIEMS) is a non-profit organisation that aims to bring together users, planners, researchers, managers, technicians, response personell, and other interested emergency management parties to learn, teach, and exchange experience, knowledge, and ideas about how information management tools can be used to avoid, mitigate, and recover from disasters and other emergencies; and consequently, how the use of information management methods and technologies may improve efficiency in emergency management. TIEMS'97 is the fourth conference in the sequence of conferences. The conferences emphasise the major goal of TIEMS: to bring together people with diverse backgrounds but who share a dedication to improve emergency management. In the discussions, formal and informal, at the conferences, nuclear scientists listen to psychologists, sociologists share ideas with engineers, and practitioners discuss emergency management issues with scientists. In recent years we have experienced a tremendous advancement in information and communication technologies and, consequently, increased the possibilities in coping with emergency situations. At the same time the management of emergency situations has typically become more complex due to the increased complexity of industrial plants which are often the sources of manmade catastrophes. Besides the aspects normally covered in the TIEMS conferences, such as decision support, modelling, handling of man-made or natural disasters, training, etc., this conference has been enhanced by including aspects involving medical car and economic constraints. (EG)

Immune thrombocytopenia. Use of a Coombs antiglobulin test to detect IgG and C3 on platelets

International Nuclear Information System (INIS)

Cines, D.B.; Schreiber, A.D.

1979-01-01

We applied a radiolabeled Coombs antiglobulin test to the diagnosis and management of immune thrombocytopenia in adults and children. This assay substantiated that the majority of patients with idiopathic thrombocytopenic purpura have increased levels of IgG on their platelets. Platelets from a patient with the post-transfusion-purpura syndrome also carried increased IgG, indicating a role for IgG antibody or IgG-containing immune complexes in the destruction of host platelets in this disease. The radiolabeled Coombs test provides a general means to help diagnose, manage, and study immune platelet disorders

Impact of pharmacists providing immunizations on adolescent influenza immunization.

Science.gov (United States)

Robison, Steve G

2016-01-01

To determine if the Oregon law change in 2011 to allow pharmacists to immunize adolescents 11 to 17 years of age increased influenza immunizations or changed existing immunization venues. With the use of Oregon's ALERT Immunization Information System (IIS), 2 measures of impact were developed. First, the change in adolescent age 11-17 influenza immunizations before (2007-2010) and after (2011-2014) the pharmacy law change was evaluated against a reference cohort (aged 7-10) not affected by the law. Community pharmacies were also compared with other types of influenza immunization sites within one of the study influenza seasons (2013-2014). From 2007 to 2014, adolescent influenza immunizations at community pharmacies increased from 36 to 6372 per year. After the 2011 pharmacy law change, adolescents aged 11 to 17 were more likely to receive an influenza immunization compared with the reference population (odds ratio, 1.21; 95% CI, 1.19-1.22). Analysis of the 2013-2014 influenza season suggests that community pharmacies immunized a different population of adolescents than other providers. The 2011 change in Oregon law allowed pharmacists to increase the total of influenza immunizations given to adolescents. Copyright © 2016 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

Management of chronic immune thrombocytopenia in children and adolescents: lessons from an Austrian national cross-sectional study of 81 patients.

Science.gov (United States)

Sipurzynski, J; Fahrner, B; Kerbl, R; Crazzolara, R; Jones, N; Ebetsberger, G; Jauk, B; Strenger, V; Wohlmuther, B; Schwinger, W; Lackner, H; Urban, C; Holter, W; Minkov, M; Kager, L; Benesch, M; Seidel, M G

2016-04-01

Chronic immune thrombocytopenia (cITP) is often associated with an underlying predisposition towards autoimmunity, recognition of which is relevant to guide treatment. International recommendations on diagnostic steps and therapeutic measures of cITP in childhood exist. However, due to the low prevalence (1-2/100,000) and a variation of availability of immunological and hematological tests and treatments across pediatric units, we postulated that these guidelines are not uniformly adhered to and that immune dysregulation syndromes remained undiscovered. To delineate the current management of children and adolescents with cITP in Austria, we performed a nationwide cross-sectional study. Between 2011 and 2014, 81 children with cITP were seen at seven centers (median age 8.75 years; range 1-17; female:male ratio 47:34) at 641 visits during 180 patient years after diagnosis of cITP (>12 months ITP duration). Additional diagnoses were noted, most frequently immune or autoimmune disorders, hematologic diseases, or infections (in 37.3%, including Evans syndrome, autoimmune lymphoproliferative syndrome, systemic lupus erythematosus, and Fanconi anemia), or other symptoms like bi- or pancytopenia (n=9), lymphoproliferation or granulomatous inflammation (n = 3). Both decision to treat as well as choice of treatment varied: smaller centers tended to observe more frequently, larger centers applied a pattern of treatment modalities that appeared to depend less on bleeding tendency than on center policy. More than 50% of therapeutic interventions occurred in bleedings scores ≤2 (of 5), suggesting a strong psychosocial intention to treat. Platelet increment upon 479 therapeutic interventions of eight types was evaluated, with multiple treatment approaches being pursued sequentially in refractory patients. These data confirm the hypothesis of heterogeneous diagnostic and therapeutic management of cITP in Austrian children and corroborate the need for (1) a precise panel of

Safety issues in cultural heritage management and critical infrastructures management

Science.gov (United States)

Soldovieri, Francesco; Masini, Nicola; Alvarez de Buergo, Monica; Dumoulin, Jean

2013-12-01

This special issue is the fourth of its kind in Journal of Geophysics and Engineering , containing studies and applications of geophysical methodologies and sensing technologies for the knowledge, conservation and security of products of human activity ranging from civil infrastructures to built and cultural heritage. The first discussed the application of novel instrumentation, surface and airborne remote sensing techniques, as well as data processing oriented to both detection and characterization of archaeological buried remains and conservation of cultural heritage (Eppelbaum et al 2010). The second stressed the importance of an integrated and multiscale approach for the study and conservation of architectural, archaeological and artistic heritage, from SAR to GPR to imaging based diagnostic techniques (Masini and Soldovieri 2011). The third enlarged the field of analysis to civil engineering structures and infrastructures, providing an overview of the effectiveness and the limitations of single diagnostic techniques, which can be overcome through the integration of different methods and technologies and/or the use of robust and novel data processing techniques (Masini et al 2012). As a whole, the special issue put in evidence the factors that affect the choice of diagnostic strategy, such as the material, the spatial characteristics of the objects or sites, the value of the objects to be investigated (cultural or not), the aim of the investigation (knowledge, conservation, restoration) and the issues to be addressed (monitoring, decay assessment). In order to complete the overview of the application fields of sensing technologies this issue has been dedicated to monitoring of cultural heritage and critical infrastructures to address safety and security issues. Particular attention has been paid to the data processing methods of different sensing techniques, from infrared thermography through GPR to SAR. Cascini et al (2013) present the effectiveness of a

Web-Based Geospatial Tools to Address Hazard Mitigation, Natural Resource Management, and Other Societal Issues

Science.gov (United States)

Hearn,, Paul P.

2009-01-01

Federal, State, and local government agencies in the United States face a broad range of issues on a daily basis. Among these are natural hazard mitigation, homeland security, emergency response, economic and community development, water supply, and health and safety services. The U.S. Geological Survey (USGS) helps decision makers address these issues by providing natural hazard assessments, information on energy, mineral, water and biological resources, maps, and other geospatial information. Increasingly, decision makers at all levels are challenged not by the lack of information, but by the absence of effective tools to synthesize the large volume of data available, and to utilize the data to frame policy options in a straightforward and understandable manner. While geographic information system (GIS) technology has been widely applied to this end, systems with the necessary analytical power have been usable only by trained operators. The USGS is addressing the need for more accessible, manageable data tools by developing a suite of Web-based geospatial applications that will incorporate USGS and cooperating partner data into the decision making process for a variety of critical issues. Examples of Web-based geospatial tools being used to address societal issues follow.

Immune Response of Multiparous Hyper-Immunized Sows against Peptides from Non-Structural and Structural Proteins of PRRSV

Directory of Open Access Journals (Sweden)

Edgar Rascón-Castelo

2015-11-01

Full Text Available The purpose of this study was to evaluate the humoral and cellular responses of commercial multiparous and hyper-immunized sows against peptides from non-structural (nsp and structural proteins of porcine reproductive and respiratory syndrome virus (PRRSV. We selected sows with different numbers of parities from a commercial farm. Management practices on this farm include the use of the MLV commercial vaccine four times per year, plus two vaccinations during the acclimation period. The humoral response was evaluated via the antibody recognition of peptides from nsp and structural proteins, and the cellular response was assessed by measuring the frequency of peptide and PRRSV-specific IFN-gamma-secreting cells (IFNγ-SC. Our results show that sows with six parities have more antibodies against peptides from structural proteins than against peptides from nsp. The analysis of the cellular response revealed that the number of immunizations did not affect the frequency of IFNγ-SC and that the response was stronger against peptides from structural proteins (M protein than against nsp (nsp2. In summary, these results demonstrate that multiparous, hyper-immunized sows have a stronger immune humoral response to PRRSV structural peptides than nsp, but no differences in IFNγ-SC against the same peptides were observed.

Logistics management in Universal Immunisation Programme.

Science.gov (United States)

Bachani, D; Bansal, R D

1990-01-01

The review of the National Immunization Programme of India in 1989 focused attention to the issue of storage and distribution of vaccines. Cold-chain equipment such as walk-in-coolers (WICs), deep freezers, ice-lined refrigerators (ILRs), and vaccine carriers proliferated after the introduction of the universal immunization program (UIP) but the available units fell short of the official targets in 1988, especially ILRs (7500 proposed and 2876 available) and vaccine carriers (250,000 proposed and 35,500 available). Some states had over 6 months of supplies of vaccines whose management posed problems of losing potency: oral polio virus (OPV) potency was acceptable in 63% of stock in 1988. Syringes, needles, stoves, pressure-cooker sterilizers, dial thermometers, and refrigerator repair kits were in short supply especially at the primary health care (PHC) level. Only 1/3 of subcenters had sterilizers and 58% had vaccines carriers. Logistics management on the state level required provision of vaccines based on previous use and eligible population with even distribution throughout the year. On the district level WICs were needed for every district with 1.5 million inhabitants. Recording of vaccine requirement, utilization, and storage would aid target allocations and avoid wastage. On the institutional and PHC level an ILR and a transporting vehicle was needed. The number of women and children eligible for immunization had to be calculated based on real population figures. Cold-chain capacity of 30,000-40,000 vials was required for a district as well as about 500 reusable syringes and needles a year along with vaccination cards exceeding the number of women and children by 10% for recordkeeping at the PHC center.

Stakeholder Perceptions of Welfare Issues and Indicators for Extensively Managed Sheep in Australia.

Science.gov (United States)

Doughty, Amanda K; Coleman, Grahame J; Hinch, Geoff N; Doyle, Rebecca E

2017-03-23

An online survey was designed to form the basis of a framework for the welfare assessment of extensively managed sheep in Australia. The survey focused on welfare compromise and useful welfare indicators. A total of 952 people completed the survey in its entirety, representing four stakeholder groups: Public (53.6%), Producer (27.4%), Scientist (9.9%), and Service provider (9.1%). Animal welfare was considered to be important by all participating groups in this survey (average score of 3.78/4). Respondents felt the welfare of grazing sheep was generally adequate but improvement was desired (2.98/5), with female members of the public rating sheep welfare significantly worse than other respondents ( p risk to welfare (3.87/5), followed by heat stress (3.79), lameness (3.57) and husbandry practices (3.37). Key indicators recognised by all respondents were those associated with pain and fear (3.98/5), nutrition (4.23), mortality/management (4.27), food on offer (4.41) and number of illness/injures in a flock (4.33). There were gender and stakeholder differences in the perceived importance of both welfare issues and indicators with women and the public consistently rating issues (all p indicators (all p < 0.05) to be of greater significance than other respondents. These results highlight the importance of including all stakeholders and an even balance of genders when developing a welfare framework that can address both practical and societal concerns.

Coaching Ethics and Immunity to Change: A Response to Kjellström

Directory of Open Access Journals (Sweden)

David Zeitler

2010-06-01

Full Text Available The Immunity to Change coaching process has risen in popularity since creators Robert Kegan and Lisa Lahey published their second book using this method, Immunity to Change: How to Overcome it and Unlock the Potential for Yourself and Your Organization (2009. Sofia Kjellström (2009 recently published an article taking a critical perspective on the ethics of using ITC in educational and vocational contexts. I argue herein that when used properly, the ITC process avoids most of the criticisms that Kjellström brings to bear on this issue. Furthermore, it is argued that private life and public life (Freud’s “love and work” are already inextricably intertwined, and methods like ITC give employers and employees the tools needed to navigate what are often highly charged issues, that we might increase our quality of life and increase our efficiency. Finally, the article summarizes the relationship between Subject/Object Theory and ITC, while also addressing the issue of developmental transformations in the coaching process.

Urbanization Increases Pathogen Pressure on Feral and Managed Honey Bees.

Directory of Open Access Journals (Sweden)

Elsa Youngsteadt

Full Text Available Given the role of infectious disease in global pollinator decline, there is a need to understand factors that shape pathogen susceptibility and transmission in bees. Here we ask how urbanization affects the immune response and pathogen load of feral and managed colonies of honey bees (Apis mellifera Linnaeus, the predominant economically important pollinator worldwide. Using quantitative real-time PCR, we measured expression of 4 immune genes and relative abundance of 10 honey bee pathogens. We also measured worker survival in a laboratory bioassay. We found that pathogen pressure on honey bees increased with urbanization and management, and the probability of worker survival declined 3-fold along our urbanization gradient. The effect of management on pathogens appears to be mediated by immunity, with feral bees expressing immune genes at nearly twice the levels of managed bees following an immune challenge. The effect of urbanization, however, was not linked with immunity; instead, urbanization may favor viability and transmission of some disease agents. Feral colonies, with lower disease burdens and stronger immune responses, may illuminate ways to improve honey bee management. The previously unexamined effects of urbanization on honey-bee disease are concerning, suggesting that urban areas may favor problematic diseases of pollinators.

Urbanization Increases Pathogen Pressure on Feral and Managed Honey Bees.

Science.gov (United States)

Youngsteadt, Elsa; Appler, R Holden; López-Uribe, Margarita M; Tarpy, David R; Frank, Steven D

2015-01-01

Given the role of infectious disease in global pollinator decline, there is a need to understand factors that shape pathogen susceptibility and transmission in bees. Here we ask how urbanization affects the immune response and pathogen load of feral and managed colonies of honey bees (Apis mellifera Linnaeus), the predominant economically important pollinator worldwide. Using quantitative real-time PCR, we measured expression of 4 immune genes and relative abundance of 10 honey bee pathogens. We also measured worker survival in a laboratory bioassay. We found that pathogen pressure on honey bees increased with urbanization and management, and the probability of worker survival declined 3-fold along our urbanization gradient. The effect of management on pathogens appears to be mediated by immunity, with feral bees expressing immune genes at nearly twice the levels of managed bees following an immune challenge. The effect of urbanization, however, was not linked with immunity; instead, urbanization may favor viability and transmission of some disease agents. Feral colonies, with lower disease burdens and stronger immune responses, may illuminate ways to improve honey bee management. The previously unexamined effects of urbanization on honey-bee disease are concerning, suggesting that urban areas may favor problematic diseases of pollinators.

Musical Instrument-Associated Health Issues and Their Management.

Science.gov (United States)

Okoshi, Kae; Minami, Taro; Kikuchi, Masahiro; Tomizawa, Yasuko

2017-09-01

Playing musical instruments can bring joy to people, but can also cause a wide variety of health issues that range from mild disorders to potentially fatal conditions. Although sports medicine is an established medical subspecialty, relatively few studies have investigated the health issues associated with musical instruments. Here we present an overview of these health issues. These include infections due to microorganisms, allergic reactions, as well as mechanical injuries from sustained high pressures within the oral, mediastinal, thoracic, and abdominal cavities. For example, wind instruments can potentially harbor thousands of pathogenic organisms. If several players share the same instrument, these instruments present potential hazards in the spread of infections. A fatal case of hypersensitivity pneumonitis in a bagpiper is particularly noteworthy. Similarly, a case of gastrointestinal anthrax in an animal-hide drummer is a reminder of this rare but highly fatal disease. Although not fatal, hearing-related disorders, neuromuscular issues, musculoskeletal problems, and contact dermatitis are also very common among instrumentalists. This review aims to illuminate these under-recognized health issues by highlighting both the common conditions and the rare but fatal cases.

Issues relating to airborne applications of HTS SQUIDs

International Nuclear Information System (INIS)

Foley, C P; Leslie, K E; Binks, R A; Lam, S H K; Du, J; Tilbrook, D L; Mitchell, E E; Macfarlane, J C; Lee, J B; Turner, R; Downey, M; Maddever, A

2002-01-01

Airborne application of HTS SQUIDs is the most difficult environment for their successful deployment. In order to operate with the sensitivity required for a particular application, there are many issues to be addressed such as the need for very wide dynamic range electronics, motion noise elimination, immunity to large changing magnetic fields and cultural noise sources. This paper reviews what is necessary to achieve an airborne system giving examples in geophysical mineral exploration. It will consider issues relating to device design and fabrication, electronics, dewar design, suspension system requirements and noise elimination methods

Issues relating to airborne applications of HTS SQUIDs

CERN Document Server

Foley, C P; Binks, R A; Lam, S H K; Du, J; Tilbrook, D L; Mitchell, E E; MacFarlane, J C; Lee, J B; Turner, R; Downey, M; Maddever, A

2002-01-01

Airborne application of HTS SQUIDs is the most difficult environment for their successful deployment. In order to operate with the sensitivity required for a particular application, there are many issues to be addressed such as the need for very wide dynamic range electronics, motion noise elimination, immunity to large changing magnetic fields and cultural noise sources. This paper reviews what is necessary to achieve an airborne system giving examples in geophysical mineral exploration. It will consider issues relating to device design and fabrication, electronics, dewar design, suspension system requirements and noise elimination methods.

Induction of antitumor immunity through xenoplacental immunization

Directory of Open Access Journals (Sweden)

Agadjanyan Michael G

2006-05-01

Full Text Available Abstract Historically cancer vaccines have yielded suboptimal clinical results. We have developed a novel strategy for eliciting antitumor immunity based upon homology between neoplastic tissue and the developing placenta. Placenta formation shares several key processes with neoplasia, namely: angiogenesis, activation of matrix metalloproteases, and active suppression of immune function. Immune responses against xenoantigens are well known to break self-tolerance. Utilizing xenogeneic placental protein extracts as a vaccine, we have successfully induced anti-tumor immunity against B16 melanoma in C57/BL6 mice, whereas control xenogeneic extracts and B16 tumor extracts where ineffective, or actually promoted tumor growth, respectively. Furthermore, dendritic cells were able to prime tumor immunity when pulsed with the placental xenoantigens. While vaccination-induced tumor regression was abolished in mice depleted of CD4 T cells, both CD4 and CD8 cells were needed to adoptively transfer immunity to naïve mice. Supporting the role of CD8 cells in controlling tumor growth are findings that only freshly isolated CD8 cells from immunized mice were capable of inducing tumor cell caspases-3 activation ex vivo. These data suggest feasibility of using xenogeneic placental preparations as a multivalent vaccine potently targeting not just tumor antigens, but processes that are essential for tumor maintenance of malignant potential.

Hepatitis A and B immunization for individuals with inherited bleeding disorders.

Science.gov (United States)

Steele, M; Cochrane, A; Wakefield, C; Stain, A-M; Ling, S; Blanchette, V; Gold, R; Ford-Jones, L

2009-03-01

Hepatitis A and B vaccines are highly effective tools that can greatly reduce infection risk in the bleeding disorder population. Although hepatitis A and B immunization for individuals with bleeding disorders is universally recommended, various advisory bodies often differ with respect to many practical aspects of vaccination. To review the published literature and guidelines and form a practical, comprehensive and consistent approach to hepatitis A and B immunization for individuals with bleeding disorders. We reviewed published immunization guidelines from North American immunization advisory bodies and published statements from North American and international haemophilia advisory bodies. A search of the MEDLINE database was performed to find original published literature pertaining to hepatitis A or B immunization of patients with haemophilia or bleeding disorder patients that provided supporting or refuting evidence for advisory body guidelines. Various advisory bodies' immunization guidelines regarding individuals with bleeding disorders have contradictory statements and often did not clarify issues (e.g. post vaccination surveillance). Published literature addressing immunization in bleeding disorder patients is sparse and mostly examines route of vaccine administration, complications and corresponding antibody response. Although the risk of hepatitis A and B infection is low, the use of simple measures such as vaccination is reasonable and advocated by haemophilia advisory bodies. Following our review of the available literature and North American guidelines, we have developed comprehensive and practical recommendations addressing hepatitis A and B immunization for the bleeding disorder population that may be applicable in Bleeding Disorder clinics.

Public and political issues in HLW management: The Spanish approach

International Nuclear Information System (INIS)

Gonzalez, V.; Molina, M.

1993-01-01

ENRESA (Empresa Nacional de Residuos Radiactivos, S.A.), is a State-owned company, founded in 1985 and is responsible for radioactive waste management in Spain. ENRESA's activities are carried out in accordance with a General Radioactive Waste Plant approved by the Spanish Government. In Spain, as in most countries, the public is concerned about many of the activities involving radioactive or rad-waste management; this concern arises for different reasons, but mainly due to lack of information on the matter. This situation leads to the information available being misused by certain politicians, green groups and media, which serves to increase the distrust with which the public sometimes views responsible companies and institutions. At the root of both these problems is a lack of political consensus regarding development of the activity. To gain public acceptance, it would be necessary to develop a long-term information policy, since in the field of communications results are only ever achieved in the long term. ENRESA is carrying out an on-going Communication Plan (CP), implemented successfully in the areas surrounding a low- and intermediate-level waste disposal site and a disused uranium mill in which remedial actions are currently being performed. Implementation of this plan at national level is being accomplished stepwise. This document deals with the most relevant issues relating to the radioactive waste situation in Spain and with the efforts made in communications

Integrated Circuit Immunity

Science.gov (United States)

Sketoe, J. G.; Clark, Anthony

2000-01-01

This paper presents a DOD E3 program overview on integrated circuit immunity. The topics include: 1) EMI Immunity Testing; 2) Threshold Definition; 3) Bias Tee Function; 4) Bias Tee Calibration Set-Up; 5) EDM Test Figure; 6) EMI Immunity Levels; 7) NAND vs. and Gate Immunity; 8) TTL vs. LS Immunity Levels; 9) TP vs. OC Immunity Levels; 10) 7805 Volt Reg Immunity; and 11) Seventies Chip Set. This paper is presented in viewgraph form.

Oral immune therapy: targeting the systemic immune system via the gut immune system for the treatment of inflammatory bowel disease.

Science.gov (United States)

Ilan, Yaron

2016-01-01

Inflammatory bowel diseases (IBD) are associated with an altered systemic immune response leading to inflammation-mediated damage to the gut and other organs. Oral immune therapy is a method of systemic immune modulation via alteration of the gut immune system. It uses the inherit ability of the innate system of the gut to redirect the systemic innate and adaptive immune responses. Oral immune therapy is an attractive clinical approach to treat autoimmune and inflammatory disorders. It can induce immune modulation without immune suppression, has minimal toxicity and is easily administered. Targeting the systemic immune system via the gut immune system can serve as an attractive novel therapeutic method for IBD. This review summarizes the current data and discusses several examples of oral immune therapeutic methods for using the gut immune system to generate signals to reset systemic immunity as a treatment for IBD.

SOME ISSUES OF THE AIRPORT MANAGEMENT

Directory of Open Access Journals (Sweden)

Marian Ovidiu

2012-07-01

Full Text Available Internationally, the recommended standards for the operation and management of civil-use airports are provided by the International Civil Aviation Organization (ICAO. In most individual countries, airports are managed directly by the government, most often under the ministry of transport. In some countries, including EU countries, some airports are privately owned and operated, although, despite private ownership, they are still subject to much of the country’s regulations regarding aviation operations. The complex system of civil airports is made up of individual airport facilities of varying sizes, serving various purposes, all organized into plans of regional, national, and international levels. The range of rules, regulations, and policies, administered from varying levels of government, cover the full spectrum of airport and aviation system operations. Furthermore, a large number of professional and industry organizations play a large part in influencing the policies by which airport management must operate their facilities. By understanding where an airport manager’s airport falls within the civil aviation system, what rules must be followed, and what sources of support and assistance exist, the task of efficiently managing the complex system that is an airport, becomes highly facilitated.

Childhood immunization, vaccine hesitancy, and provaccination policy in high-income countries

DEFF Research Database (Denmark)

Thomsen, Frej Klem

2017-01-01

Increasing vaccine hesitancy among parents in high-income countries and the resulting drop in early childhood immunization constitute an important public health problem, and raise the issue of what policies might be taken to promote higher rates of vaccination. This article first outlines the bac...

The effect of probiotics on immune regulation, acne, and photoaging

Directory of Open Access Journals (Sweden)

Mary-Margaret Kober

2015-06-01

Full Text Available Probiotics are live micro-organisms that provide a health benefit to the host. The role of probiotics in the management of disease, as well as immune modification, has recently experienced a renewed interest in society, as probiotics can be found in products ranging from yogurt to facial creams. In this article, we discuss the role of probiotics in the development of the immune system, the treatment of acne and rosacea, and protection against aging and photodamage.

Optimizing reactive responses to outbreaks of immunizing infections: balancing case management and vaccination.

Directory of Open Access Journals (Sweden)

Petra Klepac

Full Text Available For vaccine-preventable infections, immunization generally needs to be supplemented by palliative care of individuals missed by the vaccination. Costs and availability of vaccine doses and palliative care vary by disease and by region. In many situations, resources for delivery of palliative care are independent of resources required for vaccination; however we also need to consider the conservative scenario where there is some trade-off between efforts, which is of potential relevance for resource-poor settings. We formulate an SEIR model that includes those two control strategies--vaccination and palliative care. We consider their relative merit and optimal allocation in the context of a highly efficacious vaccine, and under the assumption that palliative care may reduce transmission. We investigate the utility of a range of mixed or pure strategies that can be implemented after an epidemic has started, and look for rule-of-thumb principles of how best to reduce the burden of disease during an acute outbreak over a spectrum of vaccine-preventable infections. Intuitively, we expect the best strategy to initially focus on vaccination, and enhanced palliative care after the infection has peaked, but a number of plausible realistic constraints for control result in important qualifications on the intervention strategy. The time in the epidemic when one should switch strategy depends sensitively on the relative cost of vaccine to palliative care, the available budget, and R0. Crucially, outbreak response vaccination may be more effective in managing low-R0 diseases, while high R0 scenarios enhance the importance of routine vaccination and case management.

Immune disorders in anorexia

Directory of Open Access Journals (Sweden)

Sylwia Małgorzata Słotwińska

2017-10-01

Full Text Available Anorexia nervosa is a disease involving eating disorders. It mainly affects young people, especially teenage women. The disease is often latent and occurs in many sub-clinical and partial forms. Approximately from 0.3% to 1% of the population suffers from anorexia. It has been shown that patients with anorexia develop neurotransmitter-related disorders, leading to uncontrolled changes in the immune and endocrine systems. Interactions between cytokines, neuropeptides, and neurotransmitters play an important role in disease development. Significant malnutrition induces disorders and alterations in T-cell populations. The cellular response in patients with anorexia nervosa has been shown to be normal, although opinions on this issue are controversial. Laboratory studies on neutrophils in anorexia patients showed decreased adhesion and reduced bactericidal and cell activities. Despite such unfavourable results, patients with anorexia are resistant to infections, which are very rare in this group. Glutamine improves the performance of the human immune system. The administration of glutamine to anorexia patients, as a supplement to parenteral nutrition, has resulted in significant improvements in immune system parameters. The results of previous studies on the causes and risk factors in the development of anorexia nervosa are still ambiguous. One can hope that the differences and similarities between patients with anorexia nervosa and those with other forms of protein-calorie malnutrition may be helpful in determining the relationship between nutritional status and body defences and susceptibility to infection, and can help to broaden the knowledge about the aetiopathogenesis of anorexia nervosa.

Hazard identification and risk assessment for biologics targeting the immune system.

Science.gov (United States)

Weir, Andrea B

2008-01-01

Biologic pharmaceuticals include a variety of products, such as monoclonal antibodies, fusion proteins and cytokines. Products in those classes include immunomodulatory biologics, which are intended to enhance or diminish the activity of the immune system. Immunomodulatory biologics have been approved by the U.S. FDA for a variety of indications, including cancer and inflammatory conditions. Prior to gaining approval for marketing, sponsoring companies for all types of products must demonstrate a product's safety in toxicology studies conducted in animals and show safety and efficacy in clinical trials conducted in patients. The overall goal of toxicology studies, which applies to immunomodulatory and other product types, is to identify the hazards that products pose to humans. Because biologics are generally highly selective for specific targets (receptors/epitopes), conducting toxicology studies in animal models with the target is essential. Such animals are referred to as pharmacologically relevant. Endpoints routinely included in toxicology studies, such as hematology, organ weight and histopathology, can be used to assess the effect of a product on the structure of the immune system. Additionally, specialized endpoints, such as immunophenotyping and immune function tests, can be used to define effects of immunomodulatory products on the immune system. Following hazard identification, risks posed to patients are assessed and managed. Risks can be managed through clinical trial design and risk communication, a practice that applies to immunomodulatory and other product types. Examples of risk management in clinical trial design include establishing a safe starting dose, defining the appropriate patient population and establishing appropriate patient monitoring. Risk communication starts during clinical trials and continues after product approval. A combination of hazard identification, risk assessment and risk management allows for drug development to proceed

Analysing Incentive and Cost Sharing Issues in Livestock Disease Management

DEFF Research Database (Denmark)

Biira, Juliet

This PhD thesis tackles two main issues in livestock health management: a) the incentives for animal disease prevention on Danish livestock farms and b) allocation of costs of animal disease outbreaks and animal disease preparedness, among stakeholders involved in the livestock sector. The main...... contributions of this thesis are firstly the investigation of incentives for Danish livestock farmers to prevent animal diseases at the farm level and recommendations on how they could be improved. Secondly, the exploration of a mutual fund as a possibility for risk pooling among farmers and how it can...... is used in paper 5. The thesis consists of two parts; first is the introduction section where I introduce the thesis in general and provide an overview of the objectives and main theories and the second part includes the 5 papers which address the thesis objectives. Paper 1 uses existing literature...

Adaptation in the innate immune system and heterologous innate immunity.

Science.gov (United States)

Martin, Stefan F

2014-11-01

The innate immune system recognizes deviation from homeostasis caused by infectious or non-infectious assaults. The threshold for its activation seems to be established by a calibration process that includes sensing of microbial molecular patterns from commensal bacteria and of endogenous signals. It is becoming increasingly clear that adaptive features, a hallmark of the adaptive immune system, can also be identified in the innate immune system. Such adaptations can result in the manifestation of a primed state of immune and tissue cells with a decreased activation threshold. This keeps the system poised to react quickly. Moreover, the fact that the innate immune system recognizes a wide variety of danger signals via pattern recognition receptors that often activate the same signaling pathways allows for heterologous innate immune stimulation. This implies that, for example, the innate immune response to an infection can be modified by co-infections or other innate stimuli. This "design feature" of the innate immune system has many implications for our understanding of individual susceptibility to diseases or responsiveness to therapies and vaccinations. In this article, adaptive features of the innate immune system as well as heterologous innate immunity and their implications are discussed.

Product Life Cycle - Quality Management Issues

DEFF Research Database (Denmark)

Alting, Leo; Majstorovic, Vidosav D.

2004-01-01

The strategic goal of our country is European and world integration. Within this context the management of sustainable development considered from the aspect of product’s life cycle and its quality management represents a real challenge for researchers, economy and educational system. The aim...

T cell immunity

OpenAIRE

Emel Bülbül Başkan

2013-01-01

Since birth, our immune system is constantly bombarded with self-antigens and foreign pathogens. To stay healthy, complex immune strategies have evolved in our immune system to maintain self-tolerance and to defend against foreign pathogens. Effector T cells are the key players in steering the immune responses to execute immune functions. While effector T cells were initially identified to be immune promoting, recent studies unraveled negative regulatory functions of effector T cells...

Critical management issues for the Uranium Mill Tailings Remedial Action (UMTRA) Project

International Nuclear Information System (INIS)

Themelis, J.G.; Krishnan, K.R.

1985-01-01

The Uranium Mill Tailings Radiation Control Act of 1978 (PL95-604) authorized the Secretary of Energy to enter into cooperative agreements with certain states and Indian Tribes to clean up 24 inactive uranium mill tailing sites and associated vicinity properties. The Uranium Mill Tailings Remedial Action (UMTRA) Project includes the three Federal agencies (EPA, DOE, and NRC), eleven state, Indian Tribes, and at least four major contractors. The UMTRA Project extends over a period of ten years. The standards for the Project require a design life of 1000 years with a minimum performance period of 200 years. This paper discusses the critical management issues in dealing with the UMTRA Project and identifies the development of solutions for many of those issues. The highlights to date are promulgation of EPA standards, continued support from Congress and participating states and Indian Tribes, significant leadership shown at all levels, establishment of credibility with the public, and continued motivation of the team. The challenge for tomorrow is making certain NRC will license the sites and maintaining the high level of coordination exhibited to date to assure Project completion on schedule

Development of nuclear safety issues program

Energy Technology Data Exchange (ETDEWEB)

Cho, J. C.; Yoo, S. O.; Yoon, Y. K.; Kim, H. J.; Jeong, M. J.; Noh, K. W.; Kang, D. K

2006-12-15

The nuclear safety issues are defined as the cases which affect the design and operation safety of nuclear power plants and also require the resolution action. The nuclear safety issues program (NSIP) which deals with the overall procedural requirements for the nuclear safety issues management process is developed, in accordance with the request of the scientific resolution researches and the establishment/application of the nuclear safety issues management system for the nuclear power plants under design, construction or operation. The NSIP consists of the following 4 steps; - Step 1 : Collection of candidates for nuclear safety issues - Step 2 : Identification of nuclear safety issues - Step 3 : Categorization and resolution of nuclear safety issues - Step 4 : Implementation, verification and closure The NSIP will be applied to the management directives of KINS related to the nuclear safety issues. Through the identification of the nuclear safety issues which may be related to the potential for accident/incidents at operating nuclear power plants either directly or indirectly, followed by performance of regulatory researches to resolve the safety issues, it will be possible to prevent occurrence of accidents/incidents as well as to cope with unexpected accidents/incidents by analyzing the root causes timely and scientifically and by establishing the proper flow-up or remedied regulatory actions. Moreover, the identification and resolution of the safety issues related to the new nuclear power plants completed at the design stage are also expected to make the new reactor licensing reviews effective and efficient as well as to make the possibility of accidents/incidents occurrence minimize. Therefore, the NSIP developed in this study is expected to contribute for the enhancement of the safety of nuclear power plants.

Development of nuclear safety issues program

International Nuclear Information System (INIS)

Cho, J. C.; Yoo, S. O.; Yoon, Y. K.; Kim, H. J.; Jeong, M. J.; Noh, K. W.; Kang, D. K.

2006-12-01

The nuclear safety issues are defined as the cases which affect the design and operation safety of nuclear power plants and also require the resolution action. The nuclear safety issues program (NSIP) which deals with the overall procedural requirements for the nuclear safety issues management process is developed, in accordance with the request of the scientific resolution researches and the establishment/application of the nuclear safety issues management system for the nuclear power plants under design, construction or operation. The NSIP consists of the following 4 steps; - Step 1 : Collection of candidates for nuclear safety issues - Step 2 : Identification of nuclear safety issues - Step 3 : Categorization and resolution of nuclear safety issues - Step 4 : Implementation, verification and closure The NSIP will be applied to the management directives of KINS related to the nuclear safety issues. Through the identification of the nuclear safety issues which may be related to the potential for accident/incidents at operating nuclear power plants either directly or indirectly, followed by performance of regulatory researches to resolve the safety issues, it will be possible to prevent occurrence of accidents/incidents as well as to cope with unexpected accidents/incidents by analyzing the root causes timely and scientifically and by establishing the proper flow-up or remedied regulatory actions. Moreover, the identification and resolution of the safety issues related to the new nuclear power plants completed at the design stage are also expected to make the new reactor licensing reviews effective and efficient as well as to make the possibility of accidents/incidents occurrence minimize. Therefore, the NSIP developed in this study is expected to contribute for the enhancement of the safety of nuclear power plants

Current Issues and Situation of Producer Responsibility in Waste Management in Indonesia

Directory of Open Access Journals (Sweden)

Antonius Priyo Nugroho Sulami

2017-11-01

Full Text Available Producer responsibility for wastes has been encouraged in Indonesia since 2008. The Ministry of Environment of the Republic of Indonesia also promoted the reduce, reuse, and recycle (3R concept using the community-based approach of waste banks integrated with the extended producer responsibility (EPR concept. However, related research and implementation are still limited. This study aims to identify the challenges of fulfilling producer responsibility in waste management and determine whether the integration concept could generate outcomes expected from the EPR concept. A semi-structured interview survey of several stakeholders from the government, industrial, and waste management sectors was conducted and the data generated was used to simulate an integration scheme using a system dynamics approach. Secondary data and information from Bandung municipality were used as input for the simulation. The interview survey found that the concerns and issues of fulfilling producer responsibility in waste management include lack of awareness, unavailability of clear guidelines, and the limited capacity of the current recycling sector. The results of the simulation suggested that if the integration scheme is applied, each business entity might bear the responsibility of IDR 29.4 million per year and 14.7 tons of waste per year for the scope of four sectors and IDR 34.1 million per year and 17 tons of waste per year for the scope of two sectors.

[Security Management in Clinical Laboratory Departments and Facilities: Current Status and Issues].

Science.gov (United States)

Ishida, Haku; Nakamura, Junji; Yoshida, Hiroshi; Koike, Masaru; Inoue, Yuji

2014-11-01

We conducted a questionnaire survey regarding the current activities for protecting patients' privacy and the security of information systems (IS) related to the clinical laboratory departments of university hospitals, certified training facilities for clinical laboratories, and general hospitals in Yamaguchi Prefecture. The response rate was 47% from 215 medical institutions, including three commercial clinical laboratory centers. The results showed that there were some differences in management activities among facilities with respect to continuing education, the documentation or regulation of operational management for paper records, electronic information, remaining samples, genetic testing, and laboratory information for secondary use. They were suggested to be caused by differences in functions between university and general hospitals, differences in the scale of hospitals, or whether or not hospitals have received accreditation or ISO 15189. Regarding the IS, although the majority of facilities had sufficiently employed the access control to IS, there was some room for improvement in the management of special cases such as VIPs and patients with HIV infection. Furthermore, there were issues regarding the login method for computers shared by multiple staff, the showing of the names of personnel in charge of reports, and the risks associated with direct connections to systems and the Internet and the use of portable media such as USB memory sticks. These results indicated that further efforts are necessary for each facility to continue self-assessment and make improvements.

Measuring polio immunity to plan immunization activities.

Science.gov (United States)

Voorman, Arend; Lyons, Hil M

2016-11-21

The Global Polio Eradication Initiative is closer than ever to achieving a polio-free world. Immunization activities must still be carried out in non-endemic countries to maintain population immunity at levels which will stop poliovirus from spreading if it is re-introduced from still-infected areas. In areas where there is no active transmission of poliovirus, programs must rely on surrogate indicators of population immunity to determine the appropriate immunization activities, typically caregiver-reported vaccination history obtained from non-polio acute flaccid paralysis patients identified through polio surveillance. We used regression models to examine the relationship between polio vaccination campaigns and caregiver-reported polio vaccination history. We find that in many countries, vaccination campaigns have a surprisingly weak impact on these commonly used indicators. We conclude that alternative criteria and data, such as routine immunization indicators from vaccination records or household surveys, should be considered for planning polio vaccination campaigns, and that validation of such surrogate indicators is necessary if they are to be used as the basis for program planning and risk assessment. We recommend that the GPEI and similar organizations consider or continue devoting additional resources to rigorously study population immunity and campaign effectiveness in at-risk countries. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

Assessing Effects of Pesticides on the Bee Immune System

Science.gov (United States)