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Sample records for imhex reg sign

  1. Development of a coal-fueled Internal Manifold Heat Exchanger (IMHEX reg sign ) molten carbonate fuel cell

    Energy Technology Data Exchange (ETDEWEB)

    1991-09-01

    The design of a CGMCFC electric generation plant that will provide a cost of eletricity (COE) which is lower than that of current electric generation technologies and which is competitive with other long-range electric generating systems is presented. This effort is based upon the Internal Manifold Heat Exchanger (IMHEX) technology as developed by the Institute of Gas Technology (IGT). The project was executed by selecting economic and performance objectives for alternative plant arrangements while considering process constraints identified during IMHEX fuel cell development activities at ICT. The four major subsystems of a coal-based MCFC power plant are coal gasification, gas purification, fuel cell power generation and the bottoming cycle. The design and method of operation of each subsystem can be varied, and, depending upon design choices, can have major impact on both the design of other subsystems and the resulting cost of electricity. The challenge of this project was to select, from a range of design parameters, those operating conditions that result in a preferred plant design. Computer modelling was thus used to perform sensitivity analyses of as many system variables as program resources and schedules would permit. In any systems analysis, it is imperative that the evaluation methodology be verifiable and comparable. The TAG Class I develops comparable (if imprecise) data on performance and costs for the alternative cases being studied. It identifies, from a range of options, those which merit more exacting scrutiny to be undertaken at the second level, TAG class II analysis.

  2. Development of a coal-fueled Internal Manifold Heat Exchanger (IMHEX{reg_sign}) molten carbonate fuel cell. Volumes 1--6, Final report

    Energy Technology Data Exchange (ETDEWEB)

    1991-09-01

    The design of a CGMCFC electric generation plant that will provide a cost of eletricity (COE) which is lower than that of current electric generation technologies and which is competitive with other long-range electric generating systems is presented. This effort is based upon the Internal Manifold Heat Exchanger (IMHEX) technology as developed by the Institute of Gas Technology (IGT). The project was executed by selecting economic and performance objectives for alternative plant arrangements while considering process constraints identified during IMHEX fuel cell development activities at ICT. The four major subsystems of a coal-based MCFC power plant are coal gasification, gas purification, fuel cell power generation and the bottoming cycle. The design and method of operation of each subsystem can be varied, and, depending upon design choices, can have major impact on both the design of other subsystems and the resulting cost of electricity. The challenge of this project was to select, from a range of design parameters, those operating conditions that result in a preferred plant design. Computer modelling was thus used to perform sensitivity analyses of as many system variables as program resources and schedules would permit. In any systems analysis, it is imperative that the evaluation methodology be verifiable and comparable. The TAG Class I develops comparable (if imprecise) data on performance and costs for the alternative cases being studied. It identifies, from a range of options, those which merit more exacting scrutiny to be undertaken at the second level, TAG class II analysis.

  3. Status of the M-C Power IMHEX{reg_sign} MCFC commercialization program

    Energy Technology Data Exchange (ETDEWEB)

    Laurens, R.M.; Scroppo, J.A.; Petri, R.J.; Benjamin, T.G. [M-C Power Corp., Burr Ridge, IL (United States)

    1996-12-31

    Six years ago, M-C Power (MCP) developed a comprehensive business plan to commercialize molten carbonate fuel cell (MCFC) power plants. On an annual basis the plan has been reviewed and modified to adapt to identified end user needs and technological advancements. As a result, product definition kept abreast with marketing requirements. Over the last five years, there was order and reason for subtle shifts in supply, demand, competition and pricing policies. Today, however, traditional market assessment assumptions must be challenged. There is a revolution taking place. The revolution can be summed up in one word ... deregulation. Deregulation of the airline industry led to consideration of the natural gas industry. Now that natural gas deregulation is behind us, it is electric power and telecommunications that are receiving attention. Increased emphasis is being placed on achieving market-priced power. The net result will be thinner margins for the seller and the end user. What does this mean for the commercialization of molten carbonate fuel cells?

  4. IMHEX fuel cell repeat component manufacturing continuous improvement accomplishments

    Energy Technology Data Exchange (ETDEWEB)

    Jakaitis, L.A.; Petraglia, V.J.; Bryson, E.S. [M-C Power Corp., Burr Ridge, IL (United States)] [and others

    1996-12-31

    M-C Power is taking a power generation technology that has been proven in the laboratory and is making it a commercially competitive product. There are many areas in which this technology required scale up and refinement to reach the market entry goals for the IMHEX{reg_sign} molten carbonate fuel cell power plant. One of the primary areas that needed to be addressed was the manufacturing of the fuel cell stack. Up to this point, the fuel cell stack and associated components were virtually hand made for each system to be tested. M-C Power has now continuously manufactured the repeat components for three 250 kW stacks. M-C Power`s manufacturing strategy integrated both evolutionary and revolutionary improvements into its comprehensive commercialization effort. M-C Power`s objectives were to analyze and continuously improve stack component manufacturing and assembly techniques consistent with established specifications and commercial scale production requirements. Evolutionary improvements are those which naturally occur as the production rates are increased and experience is gained. Examples of evolutionary (learning curve) improvements included reducing scrap rates and decreasing raw material costs by buying in large quantities. Revolutionary improvements result in significant design and process changes to meet cost and performance requirements of the market entry system. Revolutionary changes often involve identifying new methods and developing designs to accommodate the new process. Based upon our accomplishments, M-C Power was able to reduce the cost of continuously manufactured fuel cell repeat components from the first to third 250 kW stack by 63%. This paper documents the continuous improvement accomplishments realized by M-C Power during IMHEX{reg_sign} fuel cell repeat component manufacturing.

  5. Using Pro/ENGINEER`s{reg_sign} interface module

    Energy Technology Data Exchange (ETDEWEB)

    Schulze, J.

    1994-06-01

    When the ACCORD Process introduced Pro/ENGINEER to Sandians several years ago, a new process for design/definition was implemented. Prior to ACCORD, engineers and draftsmen worked in the 2-D mode with a program caned ANVIL{reg_sign}, which had limited capabilities. Although the transition from 2-D modeling to 3-D modeling met with some resistance, most engineers have embraced this new concept with enthusiasm They are now able to work in the 3-D mode and at increased levels of productivity with appropriate time savings never achieved before. One area that Pro/ENGINEER is noted for that this report will concentrate on, is the powerful interface module with its wide selection of transfer file configurations. This allows the engineer to create parts or assemblies and transfer them to many different second party software packages whose vendors can provide the capability for stress analysis, rapid prototypes, virtual reality environments, or many other forms of advanced manufacturing modes of communication. The ACCORD Program has at its core, the Pro/ENGINEER program from Parametric Technology Inc. Included in the ACCORD program, are several supporting programs from other vendors to make this cooperation between software packages a reality. It is possible to create parts in Pro/ENG transfer those parts to another package that has the capability to analyze the parts for deficiencies, then optimize those parts, and allow for changes to be made. Also included in this report, are other packages closely tied to Pro/ENGINEER, but not necessarily supported under the ACCORD program. Some of these packages allow you to create very impressive video productions, or allow you to meander through a virtual reality scenario. All of these new software packages will give you a new perspective on performance. This report will show how some of these interfaces work, and how you can improve your productivity if you utilize the ACCORD program as it is implemented here at Sandia.

  6. Composite molding of SPECTRA{reg_sign} extended chain polyethylene fibers in a flexible rubber matrix

    Energy Technology Data Exchange (ETDEWEB)

    McKeehan, K.

    1997-08-01

    THETA Technologies, Inc. is a multidisciplinary research and development firm involved in the design and development of affordable, lightweight, high ballistic protection modular body armor ensemble for future military, law enforcement, and specialized commercial market applications. In the course of their research, THETA Technologies, Inc. identified that current state-of-the-art in ballistic protection and overall composite reinforcement is a high density extended chain polyethylene (HDECPE) fiber known as SPECTRA{reg_sign}, a product of AlliedSignal Fibers, Petersburg, VA. SPECTRA{reg_sign} is ten times stronger than steel of equal weight. As a non-aramid polyethylene, it offers highly desirable properties in areas of resistance to chemical degradation, virtual neutral buoyancy (0.97), and increased capacity for composite bonding over competing nylon-based fibers, such as KEVLAR{reg_sign}. SPECTRA Shield{trademark}, a woven ballistic-resistant fabric using the SPECTRA{reg_sign} fiber, is presently the most effective ballistic-resistant component for both flexible and hard plate composite armors. THETA Technologies, Inc. identified a market need for a boot sole design that would measurably increase protection to the wearer without significantly degrading performance in other areas, such as flexibility and overall weight. THETA Technologies, Inc. proposed a nitrile rubber and SPECTRA{reg_sign} fiber matrix to produce an optimal boot sole. The objective of this CRADA effort was to develop and test a process for combining the SPECTRA{reg_sign} fiber, in both chopped fiber and SPECTRA Shield{trademark} form, within a semiflexible nitrile composite having desirable and marketable properties in areas of resistance to penetration and mechanical stress.

  7. Composite molding of SPECTRA{reg_sign} extended chain polyethylene fibers in a flexible rubber matrix

    Energy Technology Data Exchange (ETDEWEB)

    McKeehan, K.

    1997-08-01

    THETA Technologies, Inc. is a multidisciplinary research and development firm involved in the design and development of affordable, lightweight, high ballistic protection modular body armor ensemble for future military, law enforcement, and specialized commercial market applications. In the course of their research, THETA Technologies, Inc. identified that current state-of-the-art in ballistic protection and overall composite reinforcement is a high density extended chain polyethylene (HDECPE) fiber known as SPECTRA{reg_sign}, a product of AlliedSignal Fibers, Petersburg, VA. SPECTRA{reg_sign} is ten times stronger than steel of equal weight. As a non-aramid polyethylene, it offers highly desirable properties in areas of resistance to chemical degradation, virtual neutral buoyancy (0.97), and increased capacity for composite bonding over competing nylon-based fibers, such as KEVLAR{reg_sign}. SPECTRA Shield{trademark}, a woven ballistic-resistant fabric using the SPECTRA{reg_sign} fiber, is presently the most effective ballistic-resistant component for both flexible and hard plate composite armors. THETA Technologies, Inc. identified a market need for a boot sole design that would measurably increase protection to the wearer without significantly degrading performance in other areas, such as flexibility and overall weight. THETA Technologies, Inc. proposed a nitrile rubber and SPECTRA{reg_sign} fiber matrix to produce an optimal boot sole. The objective of this CRADA effort was to develop and test a process for combining the SPECTRA{reg_sign} fiber, in both chopped fiber and SPECTRA Shield{trademark} form, within a semiflexible nitrile composite having desirable and marketable properties in areas of resistance to penetration and mechanical stress.

  8. Pilot test of Pickliq{reg_sign} process to determine energy and environmental benefits & economic feasibility

    Energy Technology Data Exchange (ETDEWEB)

    Olsen, D.R.

    1997-07-13

    Green Technology Group (GTG) was awarded Grant No. DE-FG01-96EE 15657 in the amount of $99,904 for a project to advance GTG`s Pickliq{reg_sign} Process in the Copper and Steel Industries. The use of the Pickliq{reg_sign} Process can significantly reduce the production of waste acids containing metal salts. The Pickliq{reg_sign} Process can save energy and eliminate hazardous waste in a typical copper rod or wire mill or a typical steel wire mill. The objective of this pilot project was to determine the magnitude of the economic, energy and environmental benefits of the Pickliq{reg_sign} Process in two applications within the metal processing industry. The effectiveness of the process has already been demonstrated at facilities cleaning iron and steel with sulfuric acid. 9207 companies are reported to use sulfuric and hydrochloric acid in the USA. The USEPA TRI statistics of acid not recycled in the US is 2.4 x 10{sup 9} lbs (net) for Hydrochloric Acid and 2.0 x 10{sup 9} lbs (net) for Sulfuric Acid. The energy cost of not reclaiming acid is 10.7 x 10{sup 6} BTU/ton for Hydrochloric Acid and 21.6 x 10{sup 6} BTU/Ton for Sulfuric Acid. This means that there is a very large market for the application of the Pickliq{reg_sign} Process and the widespread use of the process will bring significant world wide savings of energy to the environment.

  9. Rosebud syncoal partnership SynCoal{sup {reg_sign}} demonstration technology development update

    Energy Technology Data Exchange (ETDEWEB)

    Sheldon, R.W. [Rosebud SynCoal Company, Billings, MT (United States); Heintz, S.J. [Department of Energy, Pittsburgh, PA (United States)

    1995-12-01

    Rosebud SynCoal{reg_sign} Partnership`s Advanced Coal Conversion Process (ACCP) is an advanced thermal coal upgrading process coupled with physical cleaning techniques to upgrade high moisture, low-rank coals to produce a high-quality, low-sulfur fuel. The coal is processed through two vibrating fluidized bed reactors where oxygen functional groups are destroyed removing chemically bound water, carboxyl and carbonyl groups, and volatile sulfur compounds. After thermal upgrading, the SynCoal{reg_sign} is cleaned using a deep-bed stratifier process to effectively separate the pyrite rich ash. The SynCoal{reg_sign} process enhances low-rank western coals with moisture contents ranging from 2555%, sulfur contents between 0.5 and 1.5 %, and heating values between 5,500 and 9,000 Btu/lb. The upgraded stable coal product has moisture contents as low as 1 %, sulfur contents as low as 0.3%, and heating values up to 12,000 Btu/lb.

  10. Feasibility of integrating other federal information systems into the Global Network of Environment and Technology, GNET{reg_sign}

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-05-01

    The Global Environment and Technology Enterprise (GETE) of the Global Environment and Technology Foundation (GETF) has been tasked by the US Department of Energy`s (DOE), Federal Energy Technology Center (FETC) to assist in reducing DOE`s cost for the Global Network of Environment and Technology (GNET{reg_sign}). As part of this task, GETE is seeking federal partners to invest in GNET{reg_sign}. The authors are also seeking FETC`s commitment to serve as GNET`s federal agency champion promoting the system to potential agency partners. This report assesses the benefits of partnering with GNET{reg_sign} and provides recommendations for identifying and integrating other federally funded (non-DOE) environmental information management systems into GNET{reg_sign}.

  11. Rosebud SynCoal Partnership, SynCoal{reg_sign} demonstration technology update

    Energy Technology Data Exchange (ETDEWEB)

    Sheldon, R.W. [Rosebud SynCoal Partnership, Billings, MT (United States)

    1997-12-31

    An Advanced Coal Conversion Process (ACCP) technology being demonstrated in eastern Montana (USA) at the heart of one of the world`s largest coal deposits is providing evidence that the molecular structure of low-rank coals can be altered successfully to produce a unique product for a variety of utility and industrial applications. The product is called SynCoal{reg_sign} and the process has been developed by the Rosebud SynCoal Partnership (RSCP) through the US Department of Energy`s multi-million dollar Clean Coal Technology Program. The ACCP demonstration process uses low-pressure, superheated gases to process coal in vibrating fluidized beds. Two vibratory fluidized processing stages are used to heat and convert the coal. This is followed by a water spray quench and a vibratory fluidized stage to cool the coal. Pneumatic separators remove the solid impurities from the dried coal. There are three major steps to the SynCoal{reg_sign} process: (1) thermal treatment of the coal in an inert atmosphere, (2) inert gas cooling of the hot coal, and (3) removal of ash minerals. When operated continuously, the demonstration plant produces over 1,000 tons per day (up to 300,000 tons per year) of SynCoal{reg_sign} with a 2% moisture content, approximately 11,800b Btu/lb and less than 1.0 pound of SO{sub 2} per million Btu. This product is obtained from Rosebud Mine sub-bituminous coal which starts with 25% moisture, 8,600 Btu/lb and approximately 1.6 pounds of SO{sub 2} per million Btu.

  12. Advanced Recyclable Media System{reg_sign}. Innovative technology summary report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-12-01

    The objective of the Large-Scale Demonstration Project (LSDP) is to select and demonstrate potentially beneficial technologies at the Argonne National Laboratory East`s (ANL) Chicago Pile-5 (CP-5) Research Reactor. The purpose of the LSDP is to demonstrate that using innovative and improved deactivation and decommissioning (D and D) technologies from various sources can result in significant benefits, such as decreased cost and increased health and safety, as compared with baseline D and D technologies. This report describes a demonstration of the Advanced Recyclable Media System{reg_sign} technology which was employed by Surface Technology Systems, Inc. to remove coatings from a concrete floor. This demonstration is part of the CP-5 LSDP sponsored by the US Department of Energy (DOE) Office of Science and Technology Deactivation and Decommissioning Focus Area (DDFA). The Advanced Recyclable Media System{reg_sign} (ARMS) technology is an open blast technology which uses a soft recyclable media. The patented ARMS Engineered Blast Media consists of a fiber-reinforced polymer matrix which can be manufactured in various grades of abrasiveness. The fiber media can be remade and/or reused up to 20 times and can clean almost any surface (e.g., metal, wood, concrete, lead) and geometry including corners and the inside of air ducts.

  13. Advanced Recyclable Media System{reg_sign}. Innovative technology summary report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-12-01

    The objective of the Large-Scale Demonstration Project (LSDP) is to select and demonstrate potentially beneficial technologies at the Argonne National Laboratory East`s (ANL) Chicago Pile-5 (CP-5) Research Reactor. The purpose of the LSDP is to demonstrate that using innovative and improved deactivation and decommissioning (D and D) technologies from various sources can result in significant benefits, such as decreased cost and increased health and safety, as compared with baseline D and D technologies. This report describes a demonstration of the Advanced Recyclable Media System{reg_sign} technology which was employed by Surface Technology Systems, Inc. to remove coatings from a concrete floor. This demonstration is part of the CP-5 LSDP sponsored by the US Department of Energy (DOE) Office of Science and Technology Deactivation and Decommissioning Focus Area (DDFA). The Advanced Recyclable Media System{reg_sign} (ARMS) technology is an open blast technology which uses a soft recyclable media. The patented ARMS Engineered Blast Media consists of a fiber-reinforced polymer matrix which can be manufactured in various grades of abrasiveness. The fiber media can be remade and/or reused up to 20 times and can clean almost any surface (e.g., metal, wood, concrete, lead) and geometry including corners and the inside of air ducts.

  14. Bioremediation of TNT-contaminated soil by the TERRANOX{reg_sign} system

    Energy Technology Data Exchange (ETDEWEB)

    Stolpmann, H.; Warrelmann, J.; Heuermann, E.; Fruechtnicht, A. [Umweltschutz Nord GmbH and Co., Ganderkesee (Germany); Lenke, H.; Daun, G. [Fraunhofer Inst. fuer Grenzflaechen und Bioverfahrenstechnik, Stuttgurt (Germany); Knackmuss, H.J. [Univ. of Stuttgart (Germany)

    1995-12-31

    A method for biological on-site treatment of 2,4,6-trinitrotoluene (TNT)-contaminated soil is presented. Laboratory and large-scale pilot experiments provide new data on how TNT and its bacterial metabolites (such as aminoaromatic chemicals) can be detoxified. The pilot project is performed in a controlled biological anaerobic/aerobic treatment process using a bioreactor called TERRANOX{reg_sign}. Experiences with TNT-contaminated soil from several former TNT production sites in Germany are based on extensive laboratory-scale experiments indicating that TNT disappears completely under strictly anaerobic conditions. A stable polymeric substances that is not able to leak out of the soil anymore is generated in the second step of the process from 2,4,6-triaminotoluene (TAT) by aerobic treatment. The careful analysis of this immobilization process, long-term behavior of the product, and ecotoxicological data are currently being investigated.

  15. Cure effects on microcracking in IM7 fiber/Matrimid 5292{reg_sign} BMI composites

    Energy Technology Data Exchange (ETDEWEB)

    Wilenski, M.S.; Shin, E.; Morgan, R.J.; Drzal, L.T. [Michigan State Univ., East Lansing, MI (United States)

    1995-12-31

    Initial results from a study of the microcracking behavior of the Matrimid 5292{reg_sign} BMI/IM7 carbon fiber system are presented. Studies were performed to determine the composite`s Stress Free Temperature (SFT) which is seen to control the presence and extent of microcracking. The SFT was determined using asymmetric laminates [0{sub 2}/90{sub 2}]. Varied post-cure cycles were utilized and it was found that until complete cure is obtained, the SFT is a function of the highest temperature experienced by the laminate, with little effect of previous thermal history. The reactions necessary to fully cure this system are not active at temperatures below 250 C, ruling out the possibility of obtaining a fully cured composite with a low SFT through extended post-cures at lower temperatures.

  16. Assessment of TEES reg sign applications for Wet Industrial Wastes: Energy benefit and economic analysis report

    Energy Technology Data Exchange (ETDEWEB)

    Elliott, D.C.; Scheer, T.H.

    1992-02-01

    Fundamental work is catalyzed biomass pyrolysis/gasification led to the Thermochemical Environmental Energy System (TEES{reg sign}) concept, a means of converting moist biomass feedstocks to high-value fuel gases such as methane. A low-temperature (350{degrees}C), pressurized (3100 psig) reaction environment and a nickel catalyst are used to reduce volumes of very high-moisture wastes such as food processing byproducts while producing useful quantities of energy. A study was conducted to assess the economic viability of a range of potential applications of the process. Cases examined included feedstocks of cheese whey, grape pomace, spent grain, and an organic chemical waste stream. The analysis indicated that only the organic chemical waste process is economically attractive in the existing energy/economic environment. However, food processing cases will become attractive as alternative disposal practices are curtailed and energy prices rise.

  17. Innovative remote monitoring of plant health for environmental applications: A joint effort between EPCOT{reg_sign} and the DOE

    Energy Technology Data Exchange (ETDEWEB)

    Robitaille, H. [Walt Disney World Resort, Lake Buena Vista, FL (United States); Capelle, G.; Di Benedetto, J. [Special Technologies Lab., Santa Barbara, CA (United States)] [and others

    1996-12-31

    In September of 1994, the US Department of Energy (DOE), Environmental Management, Office of Science and Technology for (OST) and Epcot{reg_sign} in the WALT DISNEY WORLD{reg_sign} Resort (Epcot) signed an agreement to cooperate on the research, development, and public communication and display of environmental technologies. Although Epcot and OST have distinctive missions, certain areas of their respective research and development efforts are common, including the integration of remote sensors with robotics platforms, airborne surveys for environmental characterization and monitoring, and ground based measurements of vegetation stress. The first area of cooperative R&D pursued under the agreement is the evaluation of laser-induced fluorescence imaging (LIFI), a technology developed by OST and proven effective for uranium detection. This paper describes the efforts being conducted under the Epcot-OST agreement and presents initial results. An appendix describing LIFI technology is also included.

  18. A limitation of the Microtox{reg_sign} test for toxicity measurements of nonionic surfactants

    Energy Technology Data Exchange (ETDEWEB)

    Sherrard, K.B.; Marriott, P.J.; McCormick, M.J. [Royal Melbourne Inst. of Tech. (Australia). Dept. of Applied Chemistry; Millington, K. [CSIRO, Belmont (Australia). Div. of Wool Technology

    1996-07-01

    Qualitative and quantitative analysis of the components of wastewaters is a necessary step towards determining the nature of aqueous effluents. However, toxicity levels of the effluents and receiving waters should also be determined to obtain a more comprehensive understanding of the effects the discharges may have on aquatic environments. The Microtox{reg_sign} test was successfully used to measure EC50 values of nonionic polyethoxylate surfactants. However, toxicity measurements of real samples that contain surfactants above a particular concentration, termed the critical toxicity concentration (CTC) are not valid. These samples require dilution before the test is performed, and because the relationship between toxicity and concentration is not linear above the CTC, the EC50 cannot be extrapolated back to give the toxicity of the original concentrated sample and a true estimation of toxicity is therefore not possible. This phenomenon may be related to the minimum surface tension requirement of the bacteria or other physical properties of the surfactant such as the tendency to assemble at interfaces and surfaces and the tendency to form micelles.

  19. Enhanced intrinsic bioremediation of hydrocarbons with oxygen release compound (ORC{reg_sign})

    Energy Technology Data Exchange (ETDEWEB)

    Koenigsberg, S. [Regenesis Bioremediation Products, San Juan Capistrano, CA (United States); Johnson, J. [Gram, Inc., Albuquerque, NM (United States); Odencrantz, J. [Tri-S Environmental Corp., Newport Beach, CA (United States); Norris, R. [Eckenfelder, Inc., Nashville, TN (United States)

    1996-12-01

    ORC{reg_sign} is a unique formulation of magnesium peroxide that releases oxygen at a slow and controlled rate when hydrated. The compound is insoluble and simply releases oxygen while being converted to ordinary magnesium hydroxide which is also insoluble. The rate control feature is a function of the synthesis of the molecular matrix and not achieved by a coating process. ORC is packaged in exchangeable filter socks and is contacted with contaminated groundwater via an array of wells or trenches. A linear array of filter socks generates an oxygenated zone, that can last four months to a year as a function of contaminant flux, and supports the remediating microbial consortia. The objective of this oxygen barrier is plume cut-off, however, any significant reduction of contaminant mass mediated by the oxygen barrier will serve to pull the control point back towards the source; this may play an important role in the implementation of risk reduction strategies. The results presented here support the use of oxygen barrier systems to help manage plume migration and for the control of point source contamination. The most extensively studied oxygen barrier to date, installed at a BTEX contaminated site in Belen, NM, produced a readily observable oxygen barrier and demonstrated an acceptable level of contaminant control during the course of the experiment.

  20. New inorganic/organic copolymers (ORMOCER{reg_sign}s) for dental applications

    Energy Technology Data Exchange (ETDEWEB)

    Wolter, H.; Storch, W. [Fraunhofer-Inst. fuer Silicatforschung, Wuerzburg (Germany); Ott, H. [Blendax GmbH, Mainz (Germany)

    1994-12-31

    Urethane and thioether (meth)acrylate alkoxysilanes have been used, as sol-gel precursors, for the preparation of a special family of inorganic/organic copolymers (ORMOCER{reg_sign}s). The basic silane type offers the following structural and synthetic possibilities for modifying the properties of the resulting copolymers: variation of the number of alkoxy groups, combination with other, different, sol-gel precursors, variation of the number of attached (meth)acrylate groups (1--5), and variation within the molecular segment (kind, structure and length) connecting the inorganic with the organic polymer structure. To achieve the additional organic polymer structure in the cured copolymer the use of different radically induced polymerization approaches (UV-, visible light-, thermal- and redox induced) is possible. Taking the incorporation of fillers into account, the Young`s modulus of these copolymers is adjustable in a range of 1--17,000 MPa, and the thermal expansion coefficient in a range of 17--250{center_dot}10{sup {minus}6}{center_dot}K{sup {minus}1} (5--50 C). Other advantages are the low shrinkage (1--2,8 vol.-%), the high flexural strength (up to 160 MPa), and the high abrasion resistance. This new copolymer type seems to have significant potential for medical applications, especially as dental filling material to replace the currently used controversial amalgam fillings.

  1. Removal of contaminants from equipment and debris and waste minimization using TechXtract{reg_sign} technology

    Energy Technology Data Exchange (ETDEWEB)

    Bonem, M.W. [EET, Inc., Bellaire, TX (United States)

    1997-10-01

    Under this Program Research and Development Agreement (PRDA), EET, Inc., is extending its proprietary TechXtract{reg_sign} chemical decontamination technology into an effective, economical, integrated contaminant removal system. This integrated system will consist of a series of decontamination baths using the TechXtract{reg_sign} chemical formulas, followed by a waste treatment process that will remove the contaminants from the spent chemicals. Sufficient decontamination will result so that materials can be released without restriction after they have been treated, even those materials that have traditionally been considered to be {open_quotes}undecontaminable.{close_quotes} The secondary liquid waste will then be treated to separate any hazardous and radioactive contaminants, so that the spent chemicals and wastewater can be discharged through conventional, permitted outlets. The TechXtract{reg_sign} technology is a unique process that chemically extracts hazardous contaminants from the surface and substrate of concrete, steel, and other solid materials. This technology has been used successfully to remove contaminants as varied as PCBs, radionuclides, heavy metals, and hazardous organics. The process` advantage over other alternatives is its effectiveness in safe and consistent extraction of subsurface contamination. TechXtract{reg_sign} is a proprietary process developed, owned, and provided by EET, Inc. The objective of the PRDA is to demonstrate on a full-scale basis an economical system for decontaminating equipment and debris, with further treatment of secondary waste streams to minimize waste volumes. Contaminants will be removed from the contaminated items to levels where they can be released for unrestricted use. The entire system will be designed with maximum flexibility and automation in mind.

  2. Topical safety analysis report for the transportation of the NUHOMS{reg_sign} dry shielded canister. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    None

    1993-08-01

    This Topical Safety Analysis Report (SAR) describes the design and the generic transportation licensing basis for utilizing the NUTECH HORIZONTAL MODULAR STORAGE (NUHOMS{reg_sign}) system dry shielded canister (DSC) containing twenty-four pressurized water reactor (PWR) spent fuel assemblies (SFA) in conjunction with a conceptually designed Transportation Cask. This SAR documents the design qualification of the NUHOMS{reg_sign} DSC as an integral part of a 10CFR71 Fissile Material Class III, Type B(M) Transportation Package. The package consists of the canister and a conceptual transportation cask (NUHOMS{reg_sign} Transportation Cask) with impact limiters. Engineering analysis is performed for the canister to confirm that the existing canister design complies with 10CFR71 transportation requirements. Evaluations and/or analyses is performed for criticality safety, shielding, structural, and thermal performance. Detailed engineering analysis for the transportation cask will be submitted in a future SAR requesting 10CFR71 certification of the complete waste package. Transportation operational considerations describe various operational aspects of the canister/transportation cask system. operational sequences are developed for canister transfer from storage to the transportation cask and interfaces with the cask auxiliary equipment for on- and off-site transport.

  3. Pipe Crawler{reg_sign} internal piping characterization system - deactivation and decommissioning focus area. Innovative Technology Summary Report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-02-01

    Pipe Crawler{reg_sign} is a pipe surveying system for performing radiological characterization and/or free release surveys of piping systems. The technology employs a family of manually advanced, wheeled platforms, or crawlers, fitted with one or more arrays of thin Geiger Mueller (GM) detectors operated from an external power supply and data processing unit. Survey readings are taken in a step-wise fashion. A video camera and tape recording system are used for video surveys of pipe interiors prior to and during radiological surveys. Pipe Crawler{reg_sign} has potential advantages over the baseline and other technologies in areas of cost, durability, waste minimization, and intrusiveness. Advantages include potentially reduced cost, potential reuse of the pipe system, reduced waste volume, and the ability to manage pipes in place with minimal disturbance to facility operations. Advantages over competing technologies include potentially reduced costs and the ability to perform beta-gamma surveys that are capable of passing regulatory scrutiny for free release of piping systems.

  4. Assessment of TEES{reg_sign} applications for Wet Industrial Wastes: Energy benefit and economic analysis report

    Energy Technology Data Exchange (ETDEWEB)

    Elliott, D.C.; Scheer, T.H.

    1992-02-01

    Fundamental work is catalyzed biomass pyrolysis/gasification led to the Thermochemical Environmental Energy System (TEES{reg_sign}) concept, a means of converting moist biomass feedstocks to high-value fuel gases such as methane. A low-temperature (350{degrees}C), pressurized (3100 psig) reaction environment and a nickel catalyst are used to reduce volumes of very high-moisture wastes such as food processing byproducts while producing useful quantities of energy. A study was conducted to assess the economic viability of a range of potential applications of the process. Cases examined included feedstocks of cheese whey, grape pomace, spent grain, and an organic chemical waste stream. The analysis indicated that only the organic chemical waste process is economically attractive in the existing energy/economic environment. However, food processing cases will become attractive as alternative disposal practices are curtailed and energy prices rise.

  5. Biodistribution and pharmacokinetics of In-111-labeled Stealth{reg_sign} liposomes in patients with solid tumours

    Energy Technology Data Exchange (ETDEWEB)

    Harrington, K.J.; Peters, A.M.; Mohammadtaghi, S. [Hammersmith Hospital, London (United Kingdom)] [and others

    1996-05-01

    The use of liposomal doxorubicin yields response rates of up to 70-80% in patients with AIDS-related Kaposi`s sarcoma with favourable alteration of the toxicity profile of the drug. Liposomal delivery of therapy in patients with solid cancers is currently under investigation. Our aim is to determine the biodistribution and pharmacokinetics of In-111-labeled Stealth{reg_sign} liposomes (SEQUUS{trademark}) liposomes (SEQUUS{trademark} Pharmaceuticals Inc., Menlo Park, USA) in patients with advanced solid malignant tumours. Ten patients (4 male, 6 female) with a median age of 59 (range 43 - 75) received 100 MBq of In-111-labeled Stealth{reg_sign} liposomes. Four had breast cancer, 3 head and neck tumours, 2 lung and 1 cervical cancer. Blood samples and whole body gamma camera images were obtained at 0.5, 4, 24, 48, 72, 96 and 240 hours after injection and sequential 24 hour urine collections were performed for the first 96 h. SPECT imaging was performed when indicated. High definition images of tumours were obtained in 9 patients (3/4 breast, 3/3 head and neck, 2/2 lung and 1/1 cervix cancers). One patient (breast cancer) had negative images. The median cumulative urinary excretion of In-111 over the first 96 h was 17.8 (range 3.5-21.3) % of the injected dose. The uptake of liposomes in various tissues was estimated from regions of interest on the whole body images. Prominent uptake was seen in the liver (10-15% of injected dose), lungs (4-9%) and spleen (2-8%). Tumour uptake in the first 96 h varied form 0.5-4% of the injected dose. This is approximately 10 fold higher than might be expected from experience with other targeting methods (eg monoclonal antibodies). These data confirm that Stealth liposomes have a prolonged circulation half-life and localise to solid tumour tissue.

  6. Regional coordination of the ENERGY STAR{reg{underscore}sign} residential fixture program: Design, implementation, and early observations

    Energy Technology Data Exchange (ETDEWEB)

    Moore, J.; Gordon, L.; Latham, L.

    1998-07-01

    The Northwest Energy Efficiency Alliance and a group of California utilities are implementing a unique market transformation initiative to promote the use of energy-efficient residential light fixtures. This effort is based on the current ENERGY STAR{reg{underscore}sign} specification for residential fixtures, and combines manufacturer rebates with aggressive education and marketing efforts in order to stimulate increased sales of these products. The initiative was developed in 1997, and has been underway in Idaho, Montana, Oregon, Washington, and California since early 1998. Program efforts are designed to increase the availability of qualified fixtures in the retail and electric wholesale channels throughout the five-state area, and to stimulate direct sales to large homebuilders active in the region. An RFP process was used to select six lighting manufacturers, who are now eligible to receive rebate payments of $7 to $10 for each qualified fixture shipped during 1998. A similar process will be employed in late 1998 to select the eligible manufacturers for 1999. As of May 1998, participating manufacturers have shipped over 37,000 qualifying fixtures throughout the five states covered by the program, with most units being delivered to retain stores such as Home Depot, Home Base, Eagle Hardware and Garden, and Costco. These shipments represent 10% of the 1998 program goal.

  7. Cost reduction and manufacture of the SunSine{reg_sign} AC module: Phase I Annual Report : 21 April 1998 -- 31 October 1999

    Energy Technology Data Exchange (ETDEWEB)

    Kern, E.; Kern, G.

    2000-03-06

    This report summarizes the progress made by Ascension Technology in Phase 1 of the cost reduction and manufacturing improvements of the SunSine{reg_sign} AC Module. This work, conducted under NREL subcontract, is a two-phase effort consisting of investigations into improving inverter packaging, soft switching, circuit optimization, design for manufacturing, manufacturing processes, and pilot production manufacturing. The objective of this subcontract is to significantly reduce the cost of the SunSine{reg_sign} inverter, enhance its performance, and streamline and expand the manufacturing process. During Phase 1, the soft-switching topology was designed, then refined to meet stringent cost and performance goals. This design resulted in improved performance, smaller overall footprint, and reduced costs. The aluminum inverter housing was redesigned, and the decision was made to conformal coat the circuit boards, which was verified through the HAST (Highly Accelerated Stress Testing) method. Potential international markets were identified, and the inverter is designed to be easily modified to meet the requirements of other countries. Significant cost reduction and performance improvements have been achieved in Phase I, and accomplishments during Phase I include: (1) SunSine{reg_sign} AC Module costs have been reduced enough to be able to reduce the suggested list price; (2) successful implementation of soft-switching; (3) power circuit-board size reduced 53{percent}; (4) power circuit-board component count reduced 34{percent}; (5) total inverter parts count reduced 49{percent}; (6) anticipated inverter manufacturing cost reduced 57{percent} on a $/Wp rating; (7) transformer efficiency improved 1.4{percent}; and (8) inverter efficiency improved 4.7{percent} to 91.0{percent} at 275 Wac.

  8. Chemical and radiation stability of a proprietary cesium ion exchange material manufactured from WWL membrane and SuperLig{reg_sign} 644

    Energy Technology Data Exchange (ETDEWEB)

    Brown, G.N.; Carson, K.J.; DesChane, J.R.; Elovich, R.J.; Berry, P.K.

    1996-09-01

    Pretreatment of nuclear process wastes for ion exchange removal of Cs and other radionuclides is one way to minimize amount of high-level radioactive waste at Hanford. This study evaluated Cs-selective SuperLig{reg_sign}644 (IBC Advanced Technologies, American Fork UT) entrapped in a proprietary WWL web membrane (3M) for chemical/radiation stability in simulated caustic neutralized current acid waste (NCAW), 0.5M HNO{sub 3}, water, and air. After exposure up to 2.0E+09 rad, the material was evaluated for Cs uptake in 5M sodium NCAW simulants with varying Cs contents. Radiolytic stability appears to be sufficient for ion exchange pretreatment of radioactive Cs: essentially no decrease in Cs selectivity or loading (Kd) was observed during {sup 60}Cs gamma irradiation in water or 0.5M HNO{sub 3} up to 1.0E+09 rad. Cs Kd decreased by a factor of 2 after 2.0E+09 rad exposure. Cs Kd did not change during irradiation in 5M NCAW or ambient air up to 1.0E+08 rad, but decreased by more than an order of magnitude between 1.0E+08 and 2.0E+09 rad (not typical of process conditions). Chemical stability under caustic conditions is lower than in air or under neutral/acidic conditions. Results indicate that this material is less stable in caustic solution irrespective of radiation exposure. Samples of the membrane retained their physical form throughout the entire experiment and were only slightly brittle after exposure to 2.0E+09 rad. (The material evaluated was a finely ground (400 mesh) particulate engineered to form a polymeric fiber (WWL), not the macroscopic form of SuperLig{reg_sign} 644 resin (20 to 50 mesh).)

  9. Mutational spectra of the lacI transgene isolated from Big Blue{reg_sign} mice exposed to three carcinogenic aromatic amines

    Energy Technology Data Exchange (ETDEWEB)

    Staedtler, F.; Locher, F.; Sreenan, G. [Sandoz Pharma AG, Basel (Switzerland)] [and others

    1997-10-01

    In order to evaluate the in vivo genotoxic potential of three putative genotoxic mouse liver carcinogens, high doses of 4-chloro-o-phenylenediamine, 2-nitro-p-phenylenediamine and 2, 4-diaminotoluene were tested short term in the Big Blue{reg_sign} transgenic mouse mutation assay. Small statistically significant increases in the lacI mutant frequencies in the liver by factors 1.7 to 2.0 were found. A representative number of 347 lacI mutants isolated from liver tissue of male and female animals were analyses by DNA sequencing. The mutational spectra were examined with the Adams-Skopek algorithm. The spontaneous mutational spectra from untreated male and female animals were similar and consistent with spectral Big Blue{reg_sign} control data stored in the lacI database. Most of the background mutations were located in the 5{prime} portion of the coding region of the lacI gene. Single base substitutions were most prominent. G:C to A:T transitions and G:C to T:A transversions occurred predominatly and were preferentially located at CpG sites. Despite the increases observed in the mutant frequencies of the treated animals, the corresponding mutational spectra did not differ from the controls. However, it is possible that certain classes of point mutations were substantially increased but not detected due to the limited number of sequenced mutants. In two animals treated with 2, 4- diaminotoluene unusually high mutant frequencies and the multiple occurrence of certain mutations in the liver was observed. From one of these animals six lacI mutants isolated from colon tissue were all different. Since 2, 4-diaminotoluene was shown to induce liver cell proliferation these results may reflect clonal expansion of single mutated liver cells.

  10. Modeling studies in support of the IMHEX MCFC commercialization

    Energy Technology Data Exchange (ETDEWEB)

    Jewulski, J.R.; Resnick, G.L.; Hu, W.C.S.

    1998-07-01

    Performance modeling studies are a necessary and cost effective element of the IMHEX-MCFC stack commercialization. Technologix Corporation, in cooperation with M-C Power, has developed the algorithms and computer code for two of the models in addition to modifying the PSI model for applications specific to IMHEX fuel cell concept. Three performance models support the product development effort: a modified PSI model; a two-dimensional cross-flow cell model and a three-dimensional stack model. The sizing, number and location of the stack inter-coolers in a fuel cell stack are typical model application. Recently M-C Power modified its stack configuration to cross-flow. The cross-flow allows simplified repeat parts manufacturing and reduces the risk of gas crossover. The MCFC cross-flow model developed at M-C Power supports heat loss from the stack edges, variable fuel flow rate regions and variable oxidant flow rate regions (coupled with the optimization module) among other features. Extensive computational experiments were conducted in support of the cross-flow geometry development for the MCFC stack. The oxidant flow distribution optimization was used to mitigate the hardware temperature hot-spot typical for the cross-flow geometry. The hardware temperature hot-spot increases corrosion rate, electrolyte loss, and leads to deterioration of the long-term MCFC stack performance. Under the normal operating conditions, the maximum local temperature of the cell hardware should not exceed 960 K. The mathematical optimization software was applied to find the optimum flow distribution. The minimization of the maximum hardware temperature was defined as an optimization goal. The gas flow rate in each region was selected as independent variable subjected to optimization. In some cases the authors have also added a distance between the fuel inlet and the flow region divider to the list of independent variables. The total gas flow rates, inlet gas temperatures and compositions

  11. Studies in Rheoencephalography (REG

    Directory of Open Access Journals (Sweden)

    Michael Bodo

    2010-01-01

    Full Text Available This article presents an overview of rheoencephalography (REG – electrical impedance measurements of the brain – and summarizes past and ongoing research to develop medical applications of REG for neuro-critical care and for primary prevention of stroke and cardiovascular disease. The availability of advanced electronics and computation has opened up the potential for use of REG technology as a noninvasive, continuous and inexpensive brain monitor for military and civilian applications. The clinical background information presented here introduces physiological and clinical environments where REG has potential for use in research and clinical settings. REG studies over the past three decades have involved in vitro and in vivo groups (animal and human, including more than 1500 measurements and related electronic and computational results and practical applications. In vitro studies helped researchers understand the flow/volume relationship between Doppler ultrasound and electrical impedance signals and supported development of REG data processing methods. In animal studies, REG was used to monitor the lower limit of cerebral blood flow (CBF autoregulation (AR using a newly developed algorithm. These animal studies also confirmed correlations between REG and measurements of carotid flow (CF and intracranial pressure (ICP. Human studies confirmed the applicability of REG for detecting cerebrovascular alteration, demonstrating the usefulness of REG in the field of stroke/cardio-vascular disease prevention. In these studies, REG was compared to known stroke risk factors and to results obtained using carotid ultrasound measurements. An intelligent REG system (Cerberus has been developed for primary stroke prevention. In these studies, the biologically relevant variables of the REG signal were pulse amplitude (minimum – maximum distance and duration of the anacrotic (rising portion of the REG pulse wave. The principal limitation of REG for

  12. Molten carbonate fuel cell product design and improvement. Quarterly report, January 1--March 30, 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-31

    Objective is to establish by 1998 the commercial readiness of MW- class IMHEX{reg_sign} MCFC power plants for distributed generation, cogeneration, and compressor station applications. This will require an advanced IMHEX{reg_sign} technology base, lower-cost manufacturing processes, verified balance-of-plant components, proven packaging and assembly approaches, demonstrated prototype power plants, finalized manufacturing and market distribution plans, and a committed commercialization team. Various tasks are reported on.

  13. CORPEX{reg_sign} NORM decontamination process

    Energy Technology Data Exchange (ETDEWEB)

    Azrak, R.G.

    1997-02-01

    This paper describes a commecial process which has been developed for application to the remediation of NORM deposits on metal parts or embedded in scales on such parts. The process employs a registered chemical process, involving non-RCRA regulated chemicals, which can remove fixed {sup 226,228}Radium, {sup 210}Lead, and {sup 210}Polonium. The author describes the capabilities of the chemical process which has been developed, the way it is offered to potential customers as a practical process, and numerous examples of its application in the field.

  14. Reg gene family and human diseases

    Institute of Scientific and Technical Information of China (English)

    Yu-Wei Zhang; Liu-Song Ding; Mao-De Lai

    2003-01-01

    Regenerating gene (Reg or REG) family, within the superfamily of C-type lectin, is mainly involved in the liver,pancreatic, gastric and intestinal cell proliferation or differentiation. Considerable attention has focused on Reg family and its structurally related molecules. Over the last 15 years, 17 members of the Reg family have been cloned and sequenced. They have been considered as members of a conserved protein family sharing structural and some functional properties being involved in injury, inflammation,diabetes and carcinogenesis. We previously identified Reg Ⅳ as a strong candidate for a gene that was highly expressed in colorectal adenoma when compared to normal mucosa based on suppression subtractive hybridization (SSH),reverse Northern blot, semi-quantitative reverse transcriptase PCR (RT-PCR)and Northern blot. In situ hybridization results further support that overexpression of Reg Ⅳ may be an early event in colorectal carcinogenesis. We suggest that detection of Reg Ⅳ overexpression might be useful in the early diagnosis of carcinomatous transformation of adenoma.This review summarizes the roles of Reg family in diseases in the literature as well as our recent results of Reg Ⅳ in colorectal cancer. The biological properties of Reg family and its possible roles in human diseases are discussed. We particularly focus on the roles of Reg family as sensitive reactants of tissue injury, prognostic indicators of tumor survival and early biomarkers of carcinogenesis. In addition to our current understanding of Reg gene functions, we postulate that there might be relationships between Reg family and microsatellite instability, apoptosis and cancer with a poor prognosis. Investigation of the correlation between tumor Reg expression and survival rate, and analysis of the Reg gene status in human maliganancies, are required to elucidate the biologic consequences of Reg gene expression, the implications for Reg gene regulation of cell growth, tumorigenesis

  15. Molten carbonate fuel cell product design and improvement. Quarterly report, December 1994--March 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-08-01

    Primary objective is to establish the commercial readiness of MW- class IMHEX {reg_sign} MCFC power plants for distributed generation, cogeneration, and compressor station applications. The following tasks are reported: product definition/planning, system design/analysis, manufacturing process development, packaging/assembly, test facilities, and technology development/improvement/verification.

  16. Microsoft SQL Server 6.0{reg_sign} Workbook

    Energy Technology Data Exchange (ETDEWEB)

    Augustenborg, E.C.

    1996-09-01

    This workbook was prepared for introductory training in the use of Microsoft SQL Server Version 6.0. The examples are all taken from the PUBS database that Microsoft distributes for training purposes or from the Microsoft Online Documentation. The merits of the relational database are presented.

  17. Phase III ResonantSonic{reg_sign} report

    Energy Technology Data Exchange (ETDEWEB)

    Newcomer, D.R. [comp.; Last, G.V.; Friley, J.R.; Strope, L.A.; Johnston, B.V.

    1996-09-01

    The ResonantSonic drilling system was tested at the hanford Site in the fiscal year 1991-1992 under the auspices of the Drilling Technology Development Program and the Environmental Restoration Program. The purpose of that program was to develop, test, and demonstrate drilling methods that are environmentally acceptable, safe, efficient, and cost effective when drilling and sampling in hazardous and radioactive waste sites. The cable-tool method has historically been the primary drilling method employed for characterization and remediation projects at the Hanford site. The cable-tool method can be used reliably in a wide variety of geologic conditions and yields continuous, relatively intact core samples. however, the disadvantages of this method are that the penetration rates are slow relative to most other drilling techniques. This report represents the completion of the ResonantSonic drilling program test activities. A brief description of the ResonantSonic drilling program is given. Phases I and II activities are also presented. Phase III activities are outlined. The conclusions drawn from the results and recommendations for further work to improve the drilling technology are discussed.

  18. The expression of REG 1A and REG 1B is increased during acute amebic colitis.

    Science.gov (United States)

    Peterson, Kristine M; Guo, Xiaoti; Elkahloun, Abdel G; Mondal, Dinesh; Bardhan, Pradip K; Sugawara, Akira; Duggal, Priya; Haque, Rashidul; Petri, William A

    2011-09-01

    Entamoeba histolytica, a protozoan parasite, is an important cause of diarrhea and colitis in the developing world. Amebic colitis is characterized by ulceration of the intestinal mucosa. We performed microarray analysis of intestinal biopsies during acute and convalescent amebiasis in order to identify genes potentially involved in tissue injury or repair. Colonic biopsy samples were obtained from 8 patients during acute E. histolytica colitis and again 60 days after recovery. Gene expression in the biopsies was evaluated using microarray, and confirmed by reverse transcriptase quantitative polymerase chain reaction (RT-qPCR). REG 1A and REG 1B were the most up-regulated of all genes in the human intestine in acute versus convalescent E. histolytica disease: as determined by microarray, the levels of induction were 7.4-fold and 10.7 fold for REG 1A and B; p=0.003 and p=0.006 respectively. Increased expression of REG 1A and REG 1B protein in the colonic crypt epithelial cells during acute amebiasis was similarly observed by immunohistochemistry. Because REG 1 protein is anti-apoptotic and pro-proliferative, and since E. histolytica induces apoptosis of the intestinal epithelium as part of its disease process, we next tested if REG 1 might be protective during amebiasis by preventing parasite-induced apoptosis. Intestinal epithelial cells from REG 1-/- mice were found to be more susceptible to spontaneous, and parasite-induced, apoptosis in vitro (p=0.03). We concluded that REG 1A and REG 1B were upregulated during amebiasis and may function to protect the intestinal epithelium from parasite-induced apoptosis. Published by Elsevier Ireland Ltd.

  19. RegIII proteins as gatekeepers of the intestinal epithelium

    NARCIS (Netherlands)

    Loonen, L.M.P.

    2013-01-01

    Mammalian RegIII proteins are expressed in the intestine and in the pancreas in response to inflammation or infection. In the mouse intestine, expression of RegIIIβ and RegIIIγ is increased by microbial colonization, inflammation and infection. At the outset of this thesis human PAP and m

  20. 12 CFR 742.4 - RegFlex Relief.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false RegFlex Relief. 742.4 Section 742.4 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS REGULATORY FLEXIBILITY PROGRAM § 742.4 RegFlex Relief. (a) Exemptions. RegFlex credit unions are exempt from the following...

  1. The identification and sequence analysis of a new Reg3gamma and Reg2 in the Syrian golden hamster.

    Science.gov (United States)

    Castellarin, Mauro L; Petropavlovskaia, Maria; Lipsett, Mark A; Rosenberg, Lawrence

    2007-01-01

    The regenerating (Reg) genes are associated with tissue repair and have been directly implicated in pancreatic beta-cell regeneration. A hamster Reg3, Islet neogenesis associated protein (INGAP), has been shown to possess anti-diabetic properties in rodent models. Although several Reg3 proteins have been identified in other species, INGAP is the only Reg3 found in hamsters. To identify new Reg3 genes in the hamster pancreas we employed homology reverse transcription polymerase chain reaction (RT-PCR) using degenerate Reg3 primers, followed by rapid amplification of cDNA ends (RACE). We report here the discovery of a new hamster Reg3 gene of 765 nucleotides (nt) that encodes a 174-amino acid (aa) protein. This protein sequence was identified as a novel hamster Reg3gamma with 78% and 75% identity to the rat Reg3gamma and mouse Reg3gamma protein, respectively. We also fully sequenced the previously reported partial sequence of the hamster Reg1 gene coding region using RACE to yield a 756-nt transcript that encodes a deduced 173 aa protein. This protein was identified as hamster Reg2, rather than Reg1 as was initially reported, with an 81% identity to mouse Reg2. The spatial gene expression patterns of the hamster Reg genes, analyzed by RT-PCR, were similarly distributed with low level expression being found globally throughout the body. Mice and hamsters are the only species known to carry either of the functional INGAP or Reg2 genes. It remains to be determined whether these genes bestow mice and hamsters with special regenerative abilities in the pancreas.

  2. Breast radiological cases: training with BIRADS[reg] classification

    Energy Technology Data Exchange (ETDEWEB)

    Balleyguier, C. [Radiology Department, Institut Gustave-Roussy, 39, rue Camille Desmoulins, 94805 Villejuif Cedex (France)]. E-mail: balleyguier@igr.fr; Vanel, D. [Radiology Department, Institut Gustave-Roussy, 39, rue Camille Desmoulins, 94805 Villejuif Cedex (France); Athanasiou, A. [Radiology Department, Institut Gustave-Roussy, 39, rue Camille Desmoulins, 94805 Villejuif Cedex (France); Mathieu, M.C. [Pathology Department, Institut Gustave Roussy, Villejuif (France); Sigal, R. [Radiology Department, Institut Gustave-Roussy, 39, rue Camille Desmoulins, 94805 Villejuif Cedex (France)

    2005-04-01

    The American College of Radiology has established guidelines for outcomes monitoring known as the Breast Imaging Reporting and Data System[reg]. The last edition of the BIRADS[reg] classification includes mammography, but also ultrasonography and MRI. Radiologists must be used to the BIRADS[reg] lexicon and the BIRADS[reg] assessment, in order to clarify mammography reports and to facilitate communication with the other physicians. This work is a training on 20 mammography cases to be familiar with the BIRADS[reg] classification.

  3. Work Programme 2010. Nordic Energy Regulators (NordREG)

    Energy Technology Data Exchange (ETDEWEB)

    2010-02-15

    The Nordic regulators' cooperation through NordREG is based on a strong consensus and common understanding of the Nordic market. Through mutual efforts and contributions NordREG members identify areas of work that can create added value for the Nordic electricity market. NordREG works by exchanging information and views, mapping and analysing energy market issues and by delivering statements and reports for harmonisation and improvement. In this, the regulators aim at identifying areas where NordREG can take joint action to influence Nordic or European electricity market development. NordREGs key focus in 2010 is the work towards a common Nordic retail market and the emphasis is on promoting a legal and institutional framework that supports this goal

  4. Sign Plan

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The Union Slough National Wildlife Refuge Sign Plan explains how signs are used on the Refuge to help guide and educate visitors. An inventory of current signs is...

  5. Signes Iconiques, Signes Linguistiques (Iconic Signs, Linguistic Signs)

    Science.gov (United States)

    Besse, Henri

    1974-01-01

    This article discusses the audiovisual image as sign; the classification of signs according to two different semiologies, and two different semantic theories; and the relation to different pedagogical approaches. (Text is in French.) (AM)

  6. Signes Iconiques, Signes Linguistiques (Iconic Signs, Linguistic Signs)

    Science.gov (United States)

    Besse, Henri

    1974-01-01

    This article discusses the audiovisual image as sign; the classification of signs according to two different semiologies, and two different semantic theories; and the relation to different pedagogical approaches. (Text is in French.) (AM)

  7. Purification and assays of Rhodobacter capsulatus RegB-RegA two-component signal transduction system.

    Science.gov (United States)

    Swem, Lee R; Swem, Danielle L; Wu, Jiang; Bauer, Carl E

    2007-01-01

    Two-component signal-transduction systems, composed of a histidine-sensor kinase and a DNA-binding response regulator, allow bacteria to detect environmental changes and adjust cellular physiology to live more efficiently in a broad distribution of niches. Although many two-component signal-transduction systems are known, a limited number of signals that stimulate these systems have been discovered. This chapter describes the purification and characterization of the predominant two-component signal-transduction system utilized by Rhodobacter capsulatus, a nonsulfur purple photosynthetic bacterium. Specifically, we explain the overexpression, detergent solubilization, and purification of the full-length membrane-spanning histidine-sensor kinase RegB. We also provide a method to measure autophosphorylation of RegB and discern the effect of its signal molecule, ubiquinone, on autophosphorylation levels. In addition we describe the overexpression and purification of the cognate response regulator RegA and a technique used to visualize the phosphotransfer reaction from RegB to RegA.

  8. Construction and start-up of a 250 kW natural gas fueled MCFC demonstration power plant

    Energy Technology Data Exchange (ETDEWEB)

    Figueroa, R.A.; Carter, J.; Rivera, R.; Otahal, J. [San Diego Gas & Electric, CA (United States)] [and others

    1996-12-31

    San Diego Gas & Electric (SDG&E) is participating with M-C Power in the development and commercialization program of their internally manifolded heat exchanger (IMHEX{reg_sign}) carbonate fuel cell technology. Development of the IMHEX technology base on the UNOCAL test facility resulted in the demonstration of a 250 kW thermally integrated power plant located at the Naval Air Station at Miramar, California. The members of the commercialization team lead by M-C Power (MCP) include Bechtel Corporation, Stewart & Stevenson Services, Inc., and Ishikawajima-Harima Heavy Industries (IHI). MCP produced the fuel cell stack, Bechtel was responsible for the process engineering including the control system, Stewart & Stevenson was responsible for packaging the process equipment in a skid (pumps, desulfurizer, gas heater, turbo, heat exchanger and stem generator), IHI produced a compact flat plate catalytic reformer operating on natural gas, and SDG&E assumed responsibility for plant construction, start-up and operation of the plant.

  9. Pancreatic regenerating protein (reg Ⅰ) and reg Ⅰ receptor mRNA are upregulated in rat pancreas after induction of acute pancreatitis

    Institute of Scientific and Technical Information of China (English)

    Martin H Bluth; Sameer A Patel; Brian K Dieckgraefe; Hiroshi Okamoto; Michael E Zenilman

    2006-01-01

    AIM: Pancreatic regenerating protein (reg Ⅰ) stimulates pancreatic regeneration after pancreatectomy and is mitogenic to ductal and β-cells. This suggests that reg Ⅰ and its receptor may play a role in recovery after pancreatic injury. We hypothesized that reg Ⅰ and its receptor are induced in acute pancreatitis.METHODS: Acute pancreatitis was induced in male Wistar rats by retrograde injection of 3% sodium taurocholate into the pancreatic duct. Pancreata and serum were collected 12, 24, and 36 hours after injection and from normal controls (4 rats/group). Reg Ⅰ receptor mRNA, serum reg Ⅰ protein, and tissue reg Ⅰ protein levels were determined by Northern analysis, enzymelinked immunosorbent assay (ELISA), and Western analysis, respectively. Immunohistochemistry was used to localize changes in reg Ⅰ and its receptor.RESULTS: Serum amylase levels and histology confirmed necrotizing pancreatitis in taurocholate treated rats. There was no statistically significant change in serum reg Ⅰ concentrations from controls. However,Western blot demonstrated increased tissue levels of reg Ⅰ at 24 and 36 h. This increase was localized primarily to the acinar cells and the ductal cells by immunohistochemistry. Northern blot demonstrated a significant increase in reg Ⅰ receptor mRNA expression with pancreatitis. Immunohistochemistry localized this increase to the ductal cells, islets, and acinar cells.CONCLUSION: Acute pancreatitis results in increased tissue reg Ⅰ protein levels localized to the acinar and ductal cells, and a parallel threefold induction of reg Ⅰ receptor in the ductal cells, islets, and acinar cells. These changes suggest that induction of reg Ⅰ and its receptor may be important for recovery from acute pancreatitis.

  10. Multimedia Environmental Pollutant Assessment System (MEPAS{reg_sign}): Groundwater pathway formulations

    Energy Technology Data Exchange (ETDEWEB)

    Whelan, G.; McDonald, J.P. [Pacific Northwest National Lab., Richland, WA (United States); Sato, C. [Idaho State Univ., Pocatello, ID (United States)

    1996-06-01

    This report describes the mathematical formulations used for contaminant fate and transport in the groundwater pathway of the Multimedia Environmental Pollutant Assessment System (MEPAS). It is one in a series of reports that collectively describe the components of MEPAS. The groundwater component of the MEPAS methodology models solute transport through the groundwater environment (i.e., partially saturated and saturated zones). Specifically, this component provides estimates of groundwater contaminant fluxes at various transporting medium interfaces (e.g., water table or aquifer/river interface) and contaminant concentrations at withdrawal wells. Contaminant fluxes at transporting medium interfaces represent boundary conditions for the next medium in which contaminant migration and fate is to be simulated (e.g., groundwater contamination entering a surface-water environment). Contaminant concentrations at withdrawal wells provide contaminant levels for the exposure assessment component of MEPAS. A schematic diagram illustrating the groundwater environment is presented. The migration and fate of contaminants through the groundwater environment are described by the three-dimensional, advective-dispersive equation for solute transport. The results are based on semianalytical solutions (i.e., solutions that require numerical integration) that are well established in the scientific literature. To increase computational efficiency, limits of integration are also identified.

  11. The Multimedia Environmental Pollutant Assessment System (MEPAS){reg_sign}: Source-term release formulations

    Energy Technology Data Exchange (ETDEWEB)

    Streile, G.P.; Shields, K.D.; Stroh, J.L.; Bagaasen, L.M.; Whelan, G.; McDonald, J.P.; Droppo, J.G.; Buck, J.W.

    1996-11-01

    This report is one of a series of reports that document the mathematical models in the Multimedia Environmental Pollutant Assessment System (MEPAS). Developed by Pacific Northwest National Laboratory for the US Department of Energy, MEPAS is an integrated impact assessment software implementation of physics-based fate and transport models in air, soil, and water media. Outputs are estimates of exposures and health risk assessments for radioactive and hazardous pollutants. Each of the MEPAS formulation documents covers a major MEPAS component such as source-term, atmospheric, vadose zone/groundwater, surface water, and health exposure/health impact assessment. Other MEPAS documentation reports cover the sensitivity/uncertainty formulations and the database parameter constituent property estimation methods. The pollutant source-term release component is documented in this report. MEPAS simulates the release of contaminants from a source, transport through the air, groundwater, surface water, or overland pathways, and transfer through food chains and exposure pathways to the exposed individual or population. For human health impacts, risks are computed for carcinogens and hazard quotients for noncarcinogens. MEPAS is implemented on a desktop computer with a user-friendly interface that allows the user to define the problem, input the required data, and execute the appropriate models for both deterministic and probabilistic analyses.

  12. Administration of Anti-Reg I and Anti-PAPII Antibodies Worsens Pancreatitis

    Science.gov (United States)

    Viterbo, Domenico; Callender, Gordon E; DiMaio, Theresa; Mueller, Cathy M; Smith-Norowitz, Tamar; Zenilman, Michael E; Bluth, Martin H

    2009-01-01

    Context The regeneration protein family (Reg), which includes Reg I and PAPII, is expressed in pancreas acinar cells, and increases in acute pancreatitis. We have demonstrated that Reg gene knockdown worsens severity of acute pancreatitis in the rat and hypothesize that the proteins offer a protective effect in this disease. Objective We investigated the ability of anti-Reg and anti-PAP antibody to neutralize pancreatic Reg protein and affect pancreatitis severity. Intervention Pancreatitis was induced in rats by retrograde ductal injection of 4% sodium taurocholate. Animals Eighty-four rats: 48 with induced pancreatitis, 30 sham operated, and 6 normal animals. Setting Intraductal anti-Reg I and/or anti-PAPII antibody was administered at induced pancreatitis and sham operated subgroups of 6 rats each. Main outcome measure Serum and pancreata were harvested 24 and/or 48 hours later and assessed for pancreatitis severity by pancreatic wet weight, serum C-reactive protein (CRP), amylase, PAPII levels, and histopathology. Results Animals induced with pancreatitis with administration of anti-Reg/PAP antibodies had significantly higher wet weights compared with taurocholate and histopathological analysis revealed that anti-Reg/PAP treated animals had worse tissue inflammation and necrosis compared with controls. Serum CRP, amylase, and Reg levels did not significantly differ between experimental and sham control groups. Conclusions Administration of anti-Reg/PAP antibody worsened taurocholate-induced organ specific pancreatitis. These data suggest that the Reg family of proteins is protective in acute pancreatitis. PMID:19129610

  13. Babinski sign.

    Science.gov (United States)

    Rehman, H U

    2002-09-01

    Despite all of the medical advances, Babinski sign has proved reliable in precise localization of central nervous system dysfunction. It is well accepted that Babinski sign is indicative of dysfunction of fibers within the pyramidal tract. Joseph François Félix Babinski first described the clinical significance of the reflex in 1896. He showed that the extensor plantar response was indicative of pyramidal dysfunction and that it was absent in hysteria. He also illustrated that it was present in infancy and transiently appeared in epilepsy and strychnine poisoning. Babinski also pointed to the existence of "formes frustes" of his reflex and recognized its occasional absence in patients with other clinical signs of pyramidal lesions. The sign emerges when the dysfunction of the pyramidal tract involves the fibers that project on motoneurons of foot muscles and is mediated by extensor hallucis longus. Babinski sign may not be present acutely after transverse lesions of the spinal cord or acute brain lesions because of temporary inexcitability of spinal motoneurons.

  14. Autoantibodies to REG, a beta-cell regeneration factor, in diabetic patients.

    Science.gov (United States)

    Shervani, N J; Takasawa, S; Uchigata, Y; Akiyama, T; Nakagawa, K; Noguchi, N; Takada, H; Takahashi, I; Yamauchi, A; Ikeda, T; Iwamoto, Y; Nata, K; Okamoto, H

    2004-11-01

    Regenerating gene (Reg) product, Reg, acts as an autocrine/paracrine growth factor for beta-cell regeneration. The presence of autoimmunity against REG may affect the operative of the regenerative mechanisms in beta cells of Type 1 and Type 2 diabetes patients. We screened sera from Type 1 and Type 2 diabetes subjects for anti-REG autoantibodies, searched for correlations in the general characteristics of the subjects with the presence of anti-REG autoimmunity, and tested the attenuation of REG-induced beta-cell proliferation by the autoanitibodies. We examined the occurrence of anti-REG autoantibodies in patients' sera (265 Type 1, 368 Type 2 diabetes patients, and 75 unrelated control subjects) by Western blot analysis, and evaluated inhibitory effects of the sera on REG-stimulated beta-cell proliferation by a 5'-Bromo-2'-deoxyuridine (BrdU) incorporation assay in vitro. Anti-REG autoantibodies were found in 24.9% of Type 1, 14.9% of Type 2 and 2.7% of control subjects (P = 0.0004). There were significant differences between the autoantibody positive and negative groups in the duration of disease in the Type 1 subjects (P = 0.0035), and the age of onset in the Type 2 subjects (P = 0.0274). The patient sera containing anti-REG autoantibodies significantly attenuated the BrdU incorporation by REG (35.6 +/- 4.06% of the control), whereas the nondiabetic sera without anti-REG autoantibodies scarcely reduced the incorporation (88.8 +/- 5.10%). Anti-REG autoantibodies, which retard beta-cell proliferation in vitro, are found in some diabetic patients. Thus, autoimmunity to REG may be associated with the development/acceleration of diabetes in at least some patients.

  15. Sensitivity of simulated South America Climate to the Land Surface Schemes in RegCM4

    Science.gov (United States)

    Llopart, Marta; da Rocha, Rosmeri; Reboita, Michelle; Cuadra, Santiago

    2017-04-01

    This work evaluates the impact of two land surface parameterizations on the simulated climate and its variability over South America (SA). Two numerical experiments using RegCM4 coupled with Biosphere-Atmosphere Transfer Scheme (RegBATS) and Community Land Model version 3.5 (RegCLM) land surface schemes are compared. For the period 1979-2008, RegCM4 simulations used 50 km horizontal grid spacing and the ERA-Interim reanalysis as initial and boundary conditions. For the period studied, both simulations represent the main observed spatial patterns of rainfall, air temperature and low level circulation over SA. However, concerning the precipitation intensity, RegCLM values are closer to the observations than RegBATS (it is in general, wetter) over most of SA. RegCLM also provides smaller biases for air temperature. Over the Amazon basin, the amplitudes of the annual cycles of the soil moisture, evapotranspiration and sensible heat flux are higher in RegBATS than in RegCLM. This indicates that RegBATS provides large amounts of water vapor to the atmosphere and has more available energy to increase the boundary layer and make it reach the level of free convection (higher sensible heat flux values) resulting in higher precipitation rates and a large wet bias. RegCLM is closer to the observations than RegBATS, presenting smaller wet and warm biases over the Amazon basin. On an interannual scale, the magnitudes of the anomalies of the precipitation and air temperature simulated by RegCLM are closer to the observations. In general, RegBATS simulates higher magnitude for the interannual variability signal.

  16. [Lhermitte's sign].

    Science.gov (United States)

    García-Moreno, J M; Izquierdo, G

    2002-03-01

    Besides Babinski's, Lhermitte's sign is likely the eponym mostly used in the neurological literature. We review here the history of this eponym as well as recent advances on its pathophysiology and treatment. Lhermitte's phenomenon is, on one hand, a symptom as it is spontaneously explained by patients, and, on the other hand, a sign as it may be triggered by flexion of the nape. Initially described after head and cervical spine trauma, firstly by Marie and then by Babinski, it was Jean Lhermitte who recognized on it an etiological specificity, namely, a demyelinating sign of cervical spinal posterior cords. He also made a pathophysiological interpretation of the phenomenon, namely, a stretching of posterior cords during flexion of the neck. All authors agree that this phenomenon is more common in multiple sclerosis, although it has been descibed in many other conditions. The history of how this sign was hatched, whose pathophysiology remains a mystery, is fascinating. And it is fascinating the fact that patients compare the phenomenon with a current, especially if we bear in mind that few people may have suffered an electrocution, mainly in that time when just a few ones could actually enjoy domestic electricity.

  17. Regímenes de flujo en medios porosos

    OpenAIRE

    César A. Ortega Vivas; José M. Garibay Cisneros; Salvador Barragán González; Johann Mejías Brito

    2011-01-01

    El flujo a través de un banco de prismas rectangulares fue estudiado en forma numérica, experimental y analítica en trabajos previos. En este estudio se presentaron los diferentes regímenes de flujo en dicho banco de prismas rectangulares. Para bajos números de Reynolds se observa el régimen de Darcy, a medida que aumenta el número de Reynolds los efectos inerciales van tomando mayor importancia. Éstos se comparan con diferentes configuraciones de medios porosos.

  18. Etude de l'endoribonucléase de restriction RegB.

    OpenAIRE

    Saïda, Fakhri

    2003-01-01

    The restriction endoribonuclease RegB from the bacteriophage T4 is involved in the transition between the early and the middle phase of the lytic cycle of the virus. RegB cleaves with an almost absolute specificity the GGAG sequence needed for the bacterial initiation of the translation. We characterized the toxicity level of RegB in the bacterium and presented new tools to bypass this problem. We also presented a biotechnological application of RegB for the design of a positive selection and...

  19. Excitation Function and Thick Target Yield of 186W(p,n)186Reg Reaction for Production of Therapeutic Radioisotope 186Reg

    Institute of Scientific and Technical Information of China (English)

    KANG; Meng-xiao; HUANG; Xiao-long; LIU; Li-le

    2015-01-01

    In recent years,radioactive therapy has become one of the most important methods for cancer therapy with the increasing number of the cancer patient.Now more and more attention is paid to the radionuclide used in radioactive therapy such as 67Cu,103Pd and 186Reg.186Reg is an important medically radioisotope and is regarded as the best radioisotopes used for

  20. Expression and functional characterization of Reg3A protein in Escherichia coli%抑菌蛋白Reg3A的表达纯化与功能

    Institute of Scientific and Technical Information of China (English)

    高洋; 郑文岭; 石嵘; 彭翼飞; 周琳华; 马文丽

    2011-01-01

    In order to express and characterize the biological function of protein Reg3A, the partial coding sequence without signal peptide of Reg3A gene were sub-cloned into vector of pET-32a to construct recombinant prokaryotic expression vector pET-32a-Reg3A. After induction with IPTG, the strain of E. coli BL21-Codonplus was transformed successfully with recombinant constructs, which was found to be expressing the recombinant protein in high yield and existed in the form of inclusion bodies.The inclusion body dissolved in urea was refolded into natural conformation after dialysis. The expressed protein was purified by Ni-NTA column. The purified protein, about 95% purity, was confirmed by Western blot. It was further demonstrated that the recombinant protein could effectively inhibited growth of Gram positive bacteria, which indicated that our recombinant Reg3A retained antibacterial activity. The cloning and expression of the Reg3A proteins provide basis for further characterization of the Reg3A biological function.%利用原核表达系统表达人源抑菌蛋白Reg3A,经包涵体的复性和纯化获得有体外抑菌功能的活性抑菌蛋白,并对其体外抑菌功能进行初步研究.构建Reg3A原核表达载体PET-32a-Reg3A转化补充稀缺tRNA基因的表达菌株大肠杆菌BL21-Codonplus,阳性重组子采用诱导培养基诱导5 h后,采用超声破碎的方法提取包涵体蛋白,经包涵体蛋白的纯化和透析复性后通过Ni-NTA亲和层析交换柱,获得纯度达95%的蛋白质.Western blot鉴定显示在15 kD处有特异性条带.使用纯化后的蛋白进一步进行抑菌圈实验和抑菌活性实验,对获得蛋白的体外抑菌活性进行评估,从而为进一步进行Reg3A蛋白功能的评估及应用奠定基础.

  1. Signing off

    Science.gov (United States)

    2001-05-01

    sharp that they cause paper cuts. Stains. If you accidentally spill some food or drink on your clothes, make sure you attempt to remove it as soon as possible and preferably within the same lunar cycle. Some teachers seem to think they should be worn with pride like the stains on a chemistry teacher's white coat. This is a myth. Materials. For scientists continually teaching about the wonder of smart materials, physics teachers are remarkably conservative in their choice of materials for their clothes. Try to break out from the traditional corduroy and tweed and practise what you teach. It is not acceptable to wear the actual tie you wore at school, as this will be at least 20 years old, be rather frayed and will have your name sewn in the back by your mum. Steven Chapman Science Year Manager, British Association for the Advancement of Science Signing Off takes a humorous and irreverent look at physics education. The views expressed here are those of the author and are not endorsed by the Editorial Board for Physics Education. Can you contribute a zany attitude or humorous anecdote? Please send your offering to ped@iop.org marked Signing Off.

  2. Controversy within Sign Language.

    Science.gov (United States)

    Vernon, McCay

    1987-01-01

    A review of problems with using such manual communication systems as cued speech, fingerspelling, Signed or Manual English, American Sign Language, and Pidgin Sign provides a rationale for using a combination of American Sign Language and Pidgin Sign and a few markers from Signed English for a Total Communication system. (CB)

  3. Coupling of Community Land Model with RegCM4 for Indian Summer Monsoon Simulation

    Science.gov (United States)

    Maurya, R. K. S.; Sinha, P.; Mohanty, M. R.; Mohanty, U. C.

    2017-08-01

    Three land surface schemes available in the regional climate model RegCM4 have been examined to understand the coupling between land and atmosphere for simulation of the Indian summer monsoon rainfall. The RegCM4 is coupled with biosphere-atmosphere transfer scheme (BATS) and the National Center for Atmospheric Research (NCAR) Community Land Model versions 3.5, and 4.5 (CLM3.5 and CLM4.5, respectively) and model performance is evaluated for recent drought (2009) and normal (2011) monsoon years. The CLM4.5 has a more distinct category of surface and it is capable of representing better the land surface characteristics. National Centers for Environmental Prediction (NCEP) and Department of Energy (DOE) reanalysis version 2 (NNRP2) datasets are considered as driving force to conduct the experiments for the Indian monsoon region (30°E-120°E; 30°S-50°N). The NNRP2 and India Meteorological Department (IMD) gridded precipitation data are used for verification analysis. The results indicate that RegCM4 simulations with CLM4.5 (RegCM4-CLM4.5) and CLM3.5 (RegCM4-CLM3.5) surface temperature (at 2 ms) have very low warm biases ( 1 °C), while with BATS (RegCM4-BATS) has a cold bias of about 1-3 °C in peninsular India and some parts of central India. Warm bias in the RegCM4-BATS is observed over the Indo-Gangetic plain and northwest India and the bias is more for the deficit year as compared to the normal year. However, the warm (cold) bias is less in RegCM4-CLM4.5 than other schemes for both the deficit and normal years. The model-simulated maximum (minimum) surface temperature and sensible heat flux at the surface are positively (negatively) biased in all the schemes; however, the bias is higher in RegCM4-BATS and lower in RegCM4-CLM4.5 over India. All the land surface schemes overestimated the precipitation in peninsular India and underestimated in central parts of India for both the years; however, the biases are less in RegCM4-CLM4.5 and more in RegCM4-CLM3.5 and Reg

  4. Signing off

    Science.gov (United States)

    2001-09-01

    Physics Related Aptitude Test As the teacher shortage bites anyone with a degree in science expects to walk into a school and be received, with open arms, as a physics teacher. Are they really suitable? To help you decide Signing Off provides the following invaluable psychometric test. Extensively researched and, for single users only, it comes completely free to Physics Education subscribers! (Copies of this Physics Related Aptitude Test are available to credit-card customers from prat@realripoff.com priced #35 per client, 125 dollars to US customers.) This invaluable psychometric test has been extensively researched. Your first lesson of the new school year introduces the study of electricity. Do you: A Use the notes prepared by your predecessor. B Find a video on electricity and play it to the class. C Arrange a series of exciting practical demonstrations to stimulate the young inquiring mind. D Let the children design and make their own circuits to light flashlight bulbs. Your 14-year-olds have completed a written test on heat and energy. Do you: A Mark correct only the work of students who have written their names neatly at the top LEFT HAND corner, as required. B Only set multiple choice tests, so that the computer can mark them for you. C Mark carefully by hand, explaining in detail to each student exactly how and why they have made errors and adding encouraging comments with lots of praise. D Give out correct sets of answers and allow students to mark their own work. There is a staff social. Do you: A Ask for a definition of the term 'social'. B Ask for a web-based version. C Determine to go, so that you can discuss setting up cross-curricular links with colleagues. D Join the organizing committee. Who do you admire most? A Sir Isaac Newton. B Bill Gates. C Leonardo da Vinci. D Leonardo di Caprio. You are required to teach biology class. Your response is: A Denial. B To ask for an appropriate computer simulation. C To attend a specialized course for biology

  5. Sign Language Diglossia.

    Science.gov (United States)

    Stokoe, William C., Jr.

    Charles A. Ferguson's concept of "diglossia" (1959, 1964) is used in analyzing sign language. As in Haitian Creole or Swiss German, "two or more varieties" of sign language are "used by the same speakers under different conditions"--these are here called "High" (H) sign language and "Low" (L) sign language. H sign language is formally taught…

  6. Rheoencephalography (REG) as a Non-Invasive Monitoring Alternative for the Assessment of Brain Blood Flow

    Science.gov (United States)

    2004-09-01

    bioimpedance (rheoencephalography - REG) measurement as a non-invasive, continuous method for assessing the status of cerebral blood flow (CBF) in combat...Dunster KR, Colditz PB, Ward LC. Noninvasive measurement of cerebral bioimpedance for detection of cerebral edema in the neonatal piglet. Brain Res...REG measurements and DC impedance (Ro) were recorded simultaneously on a portable IBM compatible computer using CODAS (DATAQ, Inc., Akron, OH) data

  7. The cyclic AMP phosphodiesterase RegA critically regulates encystation in social and pathogenic amoebas.

    Science.gov (United States)

    Du, Qingyou; Schilde, Christina; Birgersson, Elin; Chen, Zhi-hui; McElroy, Stuart; Schaap, Pauline

    2014-02-01

    Amoebas survive environmental stress by differentiating into encapsulated cysts. As cysts, pathogenic amoebas resist antibiotics, which particularly counteracts treatment of vision-destroying Acanthamoeba keratitis. Limited genetic tractability of amoeba pathogens has left their encystation mechanisms unexplored. The social amoeba Dictyostelium discoideum forms spores in multicellular fruiting bodies to survive starvation, while other dictyostelids, such as Polysphondylium pallidum can additionally encyst as single cells. Sporulation is induced by cAMP acting on PKA, with the cAMP phosphodiesterase RegA critically regulating cAMP levels. We show here that RegA is deeply conserved in social and pathogenic amoebas and that deletion of the RegA gene in P. pallidum causes precocious encystation and prevents cyst germination. We heterologously expressed and characterized Acanthamoeba RegA and performed a compound screen to identify RegA inhibitors. Two effective inhibitors increased cAMP levels and triggered Acanthamoeba encystation. Our results show that RegA critically regulates Amoebozoan encystation and that components of the cAMP signalling pathway could be effective targets for therapeutic intervention with encystation.

  8. Sign Language Tutoring Tool

    CERN Document Server

    Aran, Oya; Benoit, Alexandre; Carrillo, Ana Huerta; Fanard, François-Xavier; Campr, Pavel; Akarun, Lale; Caplier, Alice; Rombaut, Michele; Sankur, Bulent

    2008-01-01

    In this project, we have developed a sign language tutor that lets users learn isolated signs by watching recorded videos and by trying the same signs. The system records the user's video and analyses it. If the sign is recognized, both verbal and animated feedback is given to the user. The system is able to recognize complex signs that involve both hand gestures and head movements and expressions. Our performance tests yield a 99% recognition rate on signs involving only manual gestures and 85% recognition rate on signs that involve both manual and non manual components, such as head movement and facial expressions.

  9. Automatic sign language identification

    OpenAIRE

    Gebre, B.G.; Wittenburg, P.; Heskes, T.

    2013-01-01

    We propose a Random-Forest based sign language identification system. The system uses low-level visual features and is based on the hypothesis that sign languages have varying distributions of phonemes (hand-shapes, locations and movements). We evaluated the system on two sign languages -- British SL and Greek SL, both taken from a publicly available corpus, called Dicta Sign Corpus. Achieved average F1 scores are about 95% - indicating that sign languages can be identified with high accuracy...

  10. RegPredict: an integrated system for regulon inference in prokaryotes by comparative genomics approach

    Energy Technology Data Exchange (ETDEWEB)

    Novichkov, Pavel S.; Rodionov, Dmitry A.; Stavrovskaya, Elena D.; Novichkova, Elena S.; Kazakov, Alexey E.; Gelfand, Mikhail S.; Arkin, Adam P.; Mironov, Andrey A.; Dubchak, Inna

    2010-05-26

    RegPredict web server is designed to provide comparative genomics tools for reconstruction and analysis of microbial regulons using comparative genomics approach. The server allows the user to rapidly generate reference sets of regulons and regulatory motif profiles in a group of prokaryotic genomes. The new concept of a cluster of co-regulated orthologous operons allows the user to distribute the analysis of large regulons and to perform the comparative analysis of multiple clusters independently. Two major workflows currently implemented in RegPredict are: (i) regulon reconstruction for a known regulatory motif and (ii) ab initio inference of a novel regulon using several scenarios for the generation of starting gene sets. RegPredict provides a comprehensive collection of manually curated positional weight matrices of regulatory motifs. It is based on genomic sequences, ortholog and operon predictions from the MicrobesOnline. An interactive web interface of RegPredict integrates and presents diverse genomic and functional information about the candidate regulon members from several web resources. RegPredict is freely accessible at http://regpredict.lbl.gov.

  11. Test report on the Abacus 30 kW bimode{reg_sign} inverter and maximum power tracker (MPT)

    Energy Technology Data Exchange (ETDEWEB)

    Bonn, R.; Ginn, J.; Zirzow, J. [and others

    1995-06-01

    Sandia National Laboratories conducts the photovoltaic balance of systems (BOS) program, which is sponsored by the US Department of Energy`s Office of Energy Management. Under this program, SNL lets commercialization contracts and conducts a laboratory program designed to advance BOS technology, improve BOS component reliability, and reduce the BOS life-cycle-cost. This report details the testing of the first large US manufactured hybrid inverter and its associated maximum power tracker.

  12. PTC-6 vacuum system: WallWalker{trademark} and Blastrac{reg_sign} shot blast cleaning system

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-02-01

    The LTC Americas, Inc. wall decontamination technology consisted of two pneumatic hand-held tools: (1) a roto-peen scaler that used star cutters and (2) a 3-piston hammer with reciprocating bits. The hand-held tools were used in conjunction with the LTC PTC-6 vacuum system which captured dust and debris as the wall decontamination took place. Recommendations for improved worker safety and health during use of the PTC-6 vacuum system with hand-held tools include: (1) keeping all hoses and lines as orderly as possible in compliance with good housekeeping requirements; (2) ergonomic training to include techniques in lifting, bending, stooping, twisting, etc.; (3) use of a clamping system to hold hoses to the vacuum system; (4) a safety line on the air line connections; (5) use of a mechanical lifting system for waste drum removal; and (6) the use of ergonomically designed tools.

  13. Test report on the Abacus 30 kW bimode(reg sign) inverter and Maximum Power Tracker (MPT)

    Science.gov (United States)

    Bonn, Russell; Ginn, Jerry; Zirzow, Jeff; Sittler, Greg

    1995-06-01

    Sandia National Laboratories conducts the photovoltaic balance of systems (BOS) program, which is sponsored by the US Department of Energy's Office of Energy Management. Under this program, SNL lets commercialization contracts and conducts a laboratory program designed to advance BOS technology, improve BOS component reliability, and reduce the BOS life-cycle-cost. This report details the testing of the first large US manufactured hybrid inverter and its associated maximum power tracker.

  14. ELEFUNT test results using Titan Fortran under Ardent UNIX/reg sign/ 2. 0 on the Titan

    Energy Technology Data Exchange (ETDEWEB)

    Cody, W.J.

    1989-03-01

    This report discusses testing of the regular and ''fast'' elementary function libraries supplied with Titan Fortran on the Ardent Titan computer in the Mathematics and Computer Science Division's Advanced Computing Research Facility. Performance tests were conducted using the ELEFUNT suite of programs from the book Software Manual for the Elementary Functions by Cody and Waite. The quality of Titan arithmetic was checked with the MACHAR and PARANOIA programs. 10 refs., 4 tabs.

  15. Low-level RF LabVIEW{reg_sign} control software user`s manual: Version 1.0

    Energy Technology Data Exchange (ETDEWEB)

    1992-06-01

    This document details information on the low-level radio frequency (LLRF) software control package. The chapters in this manual cover the following topics: Chapter one describes the general operating principles of the LabVIEW software package, and also discusses the high-level menu panels which allow access to the individual control panels. Chapter two covers the control panels used for conditioning the cavity, and for controlling the accelerator under normal operating conditions. Chapter three provides information on the resonance detection and reflectometer calibration function, including the setup and status panels for each. Chapter four contain instructions on the use of those panels dedicated to controlling the cavity RF field. Chapter five discusses the control panels that provide setup and status information on the diagnostic monitor subsystem. Chapter six outlines those panels used to control the timing functions provided by the LLRF system. Finally, chapter seven describes the control panels used to monitor and adjust the alarm and limit functions of the system. Throughout the document, it is assumed that the reader has a general working knowledge of accelerators, high-power amplifier equipment, and low-level RF (LLRF) control systems. References are listed as footnotes as they occur in the text.

  16. Residual stresses in LENS[reg] components using neutron diffraction and contour method

    Energy Technology Data Exchange (ETDEWEB)

    Rangaswamy, P. [Los Alamos National Laboratory, Materials Science and Technology, Los Alamos, NM 87545 (United States)]. E-mail: partha@lanl.gov; Griffith, M.L. [Sandia National Laboratories, Albuquerque, NM 87185 (United States); Prime, M.B. [Los Alamos National Laboratory, Materials Science and Technology, Los Alamos, NM 87545 (United States); Holden, T.M. [Los Alamos National Laboratory, Materials Science and Technology, Los Alamos, NM 87545 (United States); Rogge, R.B. [National Research Council of Canada, Chalk River Laboratories Chalk River, Ont., K0J 1J0 (Canada); Edwards, J.M. [Los Alamos National Laboratory, Materials Science and Technology, Los Alamos, NM 87545 (United States); Sebring, R.J. [Los Alamos National Laboratory, Materials Science and Technology, Los Alamos, NM 87545 (United States)

    2005-06-15

    During manufacturing of components by laser engineered net shaping (LENS[reg]), a solid freeform fabrication process, the introduction of residual stresses causes deformation or in the worst case, cracking. The origin is attributed to thermal transients encountered during solidification. In the absence of reliable predictive models for the residual stresses, measurements are necessary. Residual stresses were measured in LENS[reg] samples of 316 stainless steel and Inconel 718 having simple geometrical shapes by both neutron diffraction and the contour methods. The results by the two methods are compared and discussed in the context of the growth direction during the LENS[reg] process. Surprisingly, the residual stresses are practically uni-axial, with high stresses in the growth direction.

  17. Assessment of cerebral blood flow autoregulation (CBF AR) with rheoencephalography (REG): studies in animals

    Science.gov (United States)

    Popovic, Djordje; Bodo, Michael; Pearce, Frederick; van Albert, Stephen; Garcia, Alison; Settle, Tim; Armonda, Rocco

    2013-04-01

    The ability of cerebral vasculature to regulate cerebral blood flow (CBF) in the face of changes in arterial blood pressure (SAP) or intracranial pressure (ICP) is an important guard against secondary ischemia in acute brain injuries, and official guidelines recommend that therapeutic decisions be guided by continuous monitoring of CBF autoregulation (AR). The common method for CBF AR monitoring, which rests on real-time derivation of the correlation coefficient (PRx) between slow oscillations in SAP and ICP is, however, rarely used in clinical practice because it requires invasive ICP measurements. This study investigated whether the correlation coefficient between SAP and the pulsatile component of the non-invasive transcranial bioimpedance signal (rheoencephalography, REG) could be used to assess the state and lower limit of CBF AR. The results from pigs and rhesus macaques affirm the utility of REG; however, additional animal and clinical studies are warranted to assess selectivity of automatic REG-based evaluation of CBF AR.

  18. Drought over China in the 21st Century: Results of RegCM3%Drought over China in the 21st Century: Results of RegCM3

    Institute of Scientific and Technical Information of China (English)

    LIU Ke; JIANG Da-Bang; MA Jian-Yong

    2012-01-01

    Based on 150-year simulations of a regional climate model, RegCM3, under the Special Report on Emissions Scenarios (SRES) A1B scenario, the effective drought index (EDI) is used to project the future drought change in China. During the baseline period 1986–2005, RegCM3 was found to reliably simulate the spatial pattern of drought over the country. Over the 21st century, the regionally averaged EDI should increase, corresponding to a decrease of drought, while the probability of extreme drought events should increase. Geographically, drought should clearly increase in Northeast China, the middle and lower reaches of the Yangtze River valley, Southwest China, and southern Tibet but decrease in most parts of the rest of the country.

  19. Warning Signs of Bullying

    Science.gov (United States)

    ... to talk to kids about bullying. Respond to Bullying Learn how to respond to bullying . From stopping ... Text Size: A A A Warning Signs for Bullying There are many warning signs that may indicate ...

  20. Clarence Cannon Sign Plan

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The Clarence Cannon Sign Plan explains how signs are used on the Refuge to help guide and educate visitors. An inventory of current signs is given as well as a list...

  1. Signed languages and globalization

    NARCIS (Netherlands)

    Hiddinga, A.; Crasborn, O.

    2011-01-01

    Deaf people who form part of a Deaf community communicate using a shared sign language. When meeting people from another language community, they can fall back on a flexible and highly context-dependent form of communication called international sign, in which shared elements from their own sign

  2. British Sign Name Customs

    Science.gov (United States)

    Day, Linda; Sutton-Spence, Rachel

    2010-01-01

    Research presented here describes the sign names and the customs of name allocation within the British Deaf community. While some aspects of British Sign Language sign names and British Deaf naming customs differ from those in most Western societies, there are many similarities. There are also similarities with other societies outside the more…

  3. On the System of Person-Denoting Signs in Estonian Sign Language: Estonian Name Signs

    Science.gov (United States)

    Paales, Liina

    2010-01-01

    This article discusses Estonian personal name signs. According to study there are four personal name sign categories in Estonian Sign Language: (1) arbitrary name signs; (2) descriptive name signs; (3) initialized-descriptive name signs; (4) loan/borrowed name signs. Mostly there are represented descriptive and borrowed personal name signs among…

  4. A prospective, multicentre, observational study of patients with chronic cholestatic liver diseases receiving Udiliv and reg; in India: Splendid study

    Directory of Open Access Journals (Sweden)

    Parimal Lawate

    2016-12-01

    Conclusions: NAFLD, a less perceived etiology for CCLD, was found to be a significant contributor to CCLD. Physicians recommend Udiliv and reg; due to its known efficacy and tolerability. Udiliv and reg; reduced CCLD disease burden and was found to be an effective and well-tolerated treatment option. [Int J Basic Clin Pharmacol 2016; 5(6.000: 2621-2629

  5. The Global Redox Responding RegB/RegA Signal Transduction System Regulates the Genes Involved in Ferrous Iron and Inorganic Sulfur Compound Oxidation of the Acidophilic Acidithiobacillus ferrooxidans

    Directory of Open Access Journals (Sweden)

    Danielle Moinier

    2017-07-01

    Full Text Available The chemical attack of ore by ferric iron and/or sulfuric acid releases valuable metals. The products of these reactions are recycled by iron and sulfur oxidizing microorganisms. These acidophilic chemolithotrophic prokaryotes, among which Acidithiobacillus ferrooxidans, grow at the expense of the energy released from the oxidation of ferrous iron and/or inorganic sulfur compounds (ISCs. In At. ferrooxidans, it has been shown that the expression of the genes encoding the proteins involved in these respiratory pathways is dependent on the electron donor and that the genes involved in iron oxidation are expressed before those responsible for ISCs oxidation when both iron and sulfur are present. Since the redox potential increases during iron oxidation but remains stable during sulfur oxidation, we have put forward the hypothesis that the global redox responding two components system RegB/RegA is involved in this regulation. To understand the mechanism of this system and its role in the regulation of the aerobic respiratory pathways in At. ferrooxidans, the binding of different forms of RegA (DNA binding domain, wild-type, unphosphorylated and phosphorylated-like forms of RegA on the regulatory region of different genes/operons involved in ferrous iron and ISC oxidation has been analyzed. We have shown that the four RegA forms are able to bind specifically the upstream region of these genes. Interestingly, the phosphorylation of RegA did not change its affinity for its cognate DNA. The transcriptional start site of these genes/operons has been determined. In most cases, the RegA binding site(s was (were located upstream from the −35 (or −24 box suggesting that RegA does not interfere with the RNA polymerase binding. Based on the results presented in this report, the role of the RegB/RegA system in the regulation of the ferrous iron and ISC oxidation pathways in At. ferrooxidans is discussed.

  6. The Global Redox Responding RegB/RegA Signal Transduction System Regulates the Genes Involved in Ferrous Iron and Inorganic Sulfur Compound Oxidation of the Acidophilic Acidithiobacillus ferrooxidans.

    Science.gov (United States)

    Moinier, Danielle; Byrne, Deborah; Amouric, Agnès; Bonnefoy, Violaine

    2017-01-01

    The chemical attack of ore by ferric iron and/or sulfuric acid releases valuable metals. The products of these reactions are recycled by iron and sulfur oxidizing microorganisms. These acidophilic chemolithotrophic prokaryotes, among which Acidithiobacillus ferrooxidans, grow at the expense of the energy released from the oxidation of ferrous iron and/or inorganic sulfur compounds (ISCs). In At. ferrooxidans, it has been shown that the expression of the genes encoding the proteins involved in these respiratory pathways is dependent on the electron donor and that the genes involved in iron oxidation are expressed before those responsible for ISCs oxidation when both iron and sulfur are present. Since the redox potential increases during iron oxidation but remains stable during sulfur oxidation, we have put forward the hypothesis that the global redox responding two components system RegB/RegA is involved in this regulation. To understand the mechanism of this system and its role in the regulation of the aerobic respiratory pathways in At. ferrooxidans, the binding of different forms of RegA (DNA binding domain, wild-type, unphosphorylated and phosphorylated-like forms of RegA) on the regulatory region of different genes/operons involved in ferrous iron and ISC oxidation has been analyzed. We have shown that the four RegA forms are able to bind specifically the upstream region of these genes. Interestingly, the phosphorylation of RegA did not change its affinity for its cognate DNA. The transcriptional start site of these genes/operons has been determined. In most cases, the RegA binding site(s) was (were) located upstream from the -35 (or -24) box suggesting that RegA does not interfere with the RNA polymerase binding. Based on the results presented in this report, the role of the RegB/RegA system in the regulation of the ferrous iron and ISC oxidation pathways in At. ferrooxidans is discussed.

  7. Stage-specific hypermutability of the regA locus of Volvox, a gene regulating the germ-soma dichotomy

    Energy Technology Data Exchange (ETDEWEB)

    Kirk, D.L.; Baran, G.J.; Harper, J.F.; Huskey, R.J.; Huson, K.S.; Zagris, N.

    1987-01-16

    Mutation at the regA locus confers on somatic cells of Volvox (which otherwise undergo programmed death) ability to redifferentiate as reproductive cells. Stable mutations at the regA locus, but not at other loci, were induced at high frequency when embryos at one particular stage were exposed to either UV irradiation, novobiocin, nalidixic acid, bleomycin, 4-hydroxyaminoquinoline-1-oxide, 5-bromodeoxyuridine, or 5-fluorouracil. All treatments led to some mutations that were not expressed until the second generation after treatment. The sensitive period was after somatic and reproductive cells of the next generation had been set apart, but before they had undergone cytodifferentiation. Hypermutability occurs in presumptive reproductive cells (in which regA is normally not expressed) somewhat before regA normally acts in somatic cells. We postulate that hypermutability of regA in the reproductive cells at this time reflects a change of state that the locus undergoes as it is inactivated.

  8. [Computerizing the radiological sign].

    Science.gov (United States)

    Bertaud, V; Belhadj, I; Dameron, O; Garcelon, N; Hendaoui, L; Marin, F; Duvauferrier, R

    2007-01-01

    The goal of this article is to present to the radiologist the different theories of the sign and their consequences for sign representation in computer systems. All the theories of the sign are presented, but the most relevant are highlighted in order to explain the great modeling systems currently in use (such as DICOM-SR or the UMLS). The constructivist approach of the notion of disease, the semiosis process, which starting from signs produces new signs, and the structuralist analysis of sign through language are emphasized. The purpose of this analysis is to end up with a consensual representation of the sign that can be understood by human beings and processed by machines. Such a representation, also known as an ontology, is based on a semantic organization of language, thus allowing medicine to become a truly scientific discipline. It aims at disambiguating the symbols given to machines, which will help us in our reasoning.

  9. Comprehensive screening for reg1α gene rules out association with tropical calcific pancreatitis

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    AIM: To investigate the allelic and haplotypic association of regla gene with tropical calcific pancreatitis (TCP). Since TCP is known to have a variable genetic basis, we investigated the interaction between mutations in the susceptibility genes, SPINK1 and CTSB with reg1α polymorphisms.METHODS: we analyzed the polymorphisms in the regla gene by sequencing the gene including its promoter region in 195 TCP patients and 150 ethnically matched controls, compared their allele and haplotype frequencies, and their association with the pathogenesis and pancreaticolithiasis in TCP and fibro-calculous pancreatic diabetes.RESULTS: We found 8 reported and 2 novel polymo-rphisms including an insertion-deletion polymorphism in the promoter region of reg1α. None of the 5' UTR variants altered any known transcription factor binding sites, neither did any show a statistically significant association with TCP. No association with any reg1α variants was observed on dichotomization of patients based on their N34S SPINK1 or L26V CTSB status.CONCLUSION: Polymorphisms in reg1α gene, including the regulatory variants singly or in combination with the known mutations in SPINK1 and/or CTSB genes, are not associated with tropical calcific pancreatitis.

  10. Intestinally secreted C-type lectin Reg3b attenuates salmonellosis but not listeriosis in mice

    NARCIS (Netherlands)

    Ampting, van M.T.J.; Loonen, L.M.P.; Schonewille, A.J.; Konings, I.; Vink, C.; Iovanna, J.; Chamaillard, M.; Dekker, J.; Meer, van der R.; Wells, J.; Bovee-Oudenhoven, I.M.J.

    2012-01-01

    The Reg3 protein family, including the human member designated pancreatitis-associated protein (PAP), consists of secreted proteins that contain a C-type lectin domain involved in carbohydrate binding. They are expressed by intestinal epithelial cells. Colonization of germ-free mice and intestinal i

  11. 78 FR 48771 - Proposed Collection; Comment Request for REG 209446-82 (TD 8852)

    Science.gov (United States)

    2013-08-09

    ... corporation to its shareholders. ] DATES: Written comments should be received on or before October 8, 2013 to... Items of an S Corporation to its Shareholders. OMB Number: 1545-1613. Regulation Project Number: REG-209446-82 (TD 8852) Abstract: Section 1366 requires shareholders of an S corporation to take into...

  12. 75 FR 33891 - Proposed Collection; Comment Request for REG 209446-82 (TD 8852)

    Science.gov (United States)

    2010-06-15

    ...-209446-82 (TD 8852), Passthrough of Items of an S Corporation to its Shareholders (Sec. 1.1366-1). DATES... Corporation to its Shareholders. OMB Number: 1545-1613. Regulation Project Number: REG-209446-82 (TD 8852). Abstract: Section 1366 requires shareholders of an S corporation to take into account their pro rata...

  13. An Evaluation of RegCM3_CERES for Regional Climate Modeling in China

    Institute of Scientific and Technical Information of China (English)

    CHEN Feng; XIE Zhenghui

    2013-01-01

    A 20-year simulation of regional climate over East Asia by the regional climate model RegCM3_CERES (Regional Climate Model version 3 coupled with the Crop Estimation through Resource and Environment Synthesis) was carried out and compared with observations and the original RegCM3 model to comprehensively evaluate its performance in simulating the regional climate over continental China.The results showed that RegCM3_CERES reproduced the regional climate at a resolution of 60 km over China by using ERA40 data as the boundary conditions,albeit with some limitations.The model captured the basic characteristics of the East Asian circulation,the spatial distribution of mean precipitation and temperature,and the daily characteristics of precipitation and temperature.However,it underestimated both the intensity of the monsoon in the monsoonal area and precipitation in southern China,overestimated precipitation in northern China,and produced a systematic cold temperature bias over most of continental China.Despite these limitations,it was concluded that the RegCM3_CERES model is able to simulate the regional climate over continental China reasonably well.

  14. CoryneRegNet 4.0 – A reference database for corynebacterial gene regulatory networks

    Directory of Open Access Journals (Sweden)

    Baumbach Jan

    2007-11-01

    Full Text Available Abstract Background Detailed information on DNA-binding transcription factors (the key players in the regulation of gene expression and on transcriptional regulatory interactions of microorganisms deduced from literature-derived knowledge, computer predictions and global DNA microarray hybridization experiments, has opened the way for the genome-wide analysis of transcriptional regulatory networks. The large-scale reconstruction of these networks allows the in silico analysis of cell behavior in response to changing environmental conditions. We previously published CoryneRegNet, an ontology-based data warehouse of corynebacterial transcription factors and regulatory networks. Initially, it was designed to provide methods for the analysis and visualization of the gene regulatory network of Corynebacterium glutamicum. Results Now we introduce CoryneRegNet release 4.0, which integrates data on the gene regulatory networks of 4 corynebacteria, 2 mycobacteria and the model organism Escherichia coli K12. As the previous versions, CoryneRegNet provides a web-based user interface to access the database content, to allow various queries, and to support the reconstruction, analysis and visualization of regulatory networks at different hierarchical levels. In this article, we present the further improved database content of CoryneRegNet along with novel analysis features. The network visualization feature GraphVis now allows the inter-species comparisons of reconstructed gene regulatory networks and the projection of gene expression levels onto that networks. Therefore, we added stimulon data directly into the database, but also provide Web Service access to the DNA microarray analysis platform EMMA. Additionally, CoryneRegNet now provides a SOAP based Web Service server, which can easily be consumed by other bioinformatics software systems. Stimulons (imported from the database, or uploaded by the user can be analyzed in the context of known

  15. Variations in temperature and precipitation during Indian summer monsoon simulated by RegCM3

    Science.gov (United States)

    Dash, S. K.; Mamgain, A.; Pattnayak, K. C.; Giorgi, F.

    2012-04-01

    Variations in temperature and precipitation due to global changes have large societal impact in sectors such as agriculture and health. It is therefore very important to examine their temporal and spatial variations at the regional level in order to access the impact of climate change. In India, the most important quasi-periodic system to affect the weather and climate is the Indian summer monsoon. The local changes in the temperature and precipitation can be well examined by a regional model. RegCM3 is one such model best suited for the Indian region. This model has been integrated in the ensemble mode at 55km resolution over India for the summer monsoon season during the years 1982-2009. The model simulations are compared with observed values in detail. Comparison with observations shows that RegCM3 has slightly underestimated summer monsoon precipitation over the Central and Northeast India. Nevertheless, over these regions, RegCM3 simulated rainfall is closer to the observations when compared to other regions where rainfall is highly overestimated. The model simulated mid-tropospheric temperature shows a warm bias over the Himalayan and Tibetan regions that gives leads to the low pressure in the region. Thus the position of the monsoon trough as simulated by the model lies to the north of its original position. This is similar to the usual monsoon break condition leading to less rainfall over Central India. RegCM3 simulated surface maximum temperature shows large negative bias over the country while the surface minimum temperature is close to the observation. Nevertheless, there is a strong correlation between the all India weighted average surface temperature simulated by RegCM3 and IMD observations. At the regional level, in the Central India, both rainfall and temperature show the best correlation with the respective observed values. While examining the extreme condition in Central India, it is found that RegCM3 simulated frequencies of very wet and

  16. The sandwich sign

    Directory of Open Access Journals (Sweden)

    Nasreen Mahomed

    2012-09-01

    Full Text Available The sandwich sign refers to the sandwiching of mesenteric vessels and fat by enlarged mesenteric nodes on cross-sectional imaging, commonly occurring in lymphoma, but not specific to lymphoma. The sign is radiologically indistinguishable from post-transplant lymphoproliferative disorders. The radiological significance of the sandwich sign is in suggesting the diagnosis of lymphoma so that appropriate treatment may be initiated early as the tumour has a rapid growth pattern.

  17. Traffic Signs Inventory System

    Directory of Open Access Journals (Sweden)

    J. Ružbarský

    2013-06-01

    Full Text Available The paper is focused on practical application of Cambridge Correlator. The goal is to propose a traffic signs inventory system by using excellent characteristics of correlator in the rapid optical correlation. The proposal of this inventory system includes obtaining of traffic signs to create the database either collecting the GPS coordinates. It is necessary to know the traffic signs position and also to document the entire surface route for later evaluation in offline mode.

  18. The Forbidden Signs

    DEFF Research Database (Denmark)

    Kilstrup, Mogens

    2016-01-01

    is an important addition that offers insight into the hardware requirements for bio-semiosis. As any type of semiosis must be dependent upon Semiotic scaffolds, I recently argued that the process of semiosis has to be divided into two separate processes of sign establishment and sign interpretation....... I also show that biological semiosis offers examples of forbidden signs, where the faulty interpretation of signs may lead to decimation of whole evolutionary lines of organisms. A new concept of Evolutionary memory which is applicable to both human and biological semiosis is explained...

  19. Increased levels of regulatory T cells (T(regs)) in human immunodeficiency virus-infected patients after 5 years of highly active anti-retroviral therapy may be due to increased thymic production of naive T(regs)

    DEFF Research Database (Denmark)

    Kolte, L; Gaardbo, J C; Skogstrand, K

    2008-01-01

    (+)human leucocyte antigen D-related) were determined by flow cytometry. Forkhead box P3 mRNA expression and T cell receptor excision circles (T(REC)) content in CD4(+) cells were determined by polymerase chain reaction and cytokines analysed with Luminex technology. Levels of T(regs) were significantly......Summary This study determines levels of regulatory T cells (T(regs)), naive T(regs), immune activation and cytokine patterns in 15 adult human immunodeficiency virus (HIV)-infected patients receiving prolonged highly active anti-retroviral therapy (HAART) who have known thymic output, and explores...

  20. Expression and Significance of the HIP/PAP and RegIIIγ Antimicrobial Peptides during Mammalian Urinary Tract Infection.

    Science.gov (United States)

    Spencer, John David; Jackson, Ashley R; Li, Birong; Ching, Christina B; Vonau, Martin; Easterling, Robert S; Schwaderer, Andrew L; McHugh, Kirk M; Becknell, Brian

    2015-01-01

    Recent evidence indicates that antimicrobial peptides (AMPs) serve key roles in defending the urinary tract against invading uropathogens. To date, the individual contribution of AMPs to urinary tract host defense is not well defined. In this study, we identified Regenerating islet-derived 3 gamma (RegIIIγ) as the most transcriptionally up-regulated AMP in murine bladder transcriptomes following uropathogenic Escherichia coli (UPEC) infection. We confirmed induction of RegIIIγ mRNA during cystitis and pyelonephritis by quantitative RT-PCR. Immunoblotting demonstrates increased bladder and urinary RegIIIγ protein levels following UPEC infection. Immunostaining localizes RegIIIγ protein to urothelial cells of infected bladders and kidneys. Human patients with UTI have increased urine concentrations of the orthologous Hepatocarcinoma-Intestine-Pancreas / Pancreatitis Associated Protein (HIP/PAP) compared to healthy controls. Recombinant RegIIIγ protein does not demonstrate bactericidal activity toward UPEC in vitro, but does kill Staphylococcus saprophyticus in a dose-dependent manner. Kidney and bladder tissue from RegIIIγ knockout mice and wild-type mice contain comparable bacterial burden following UPEC and Gram-positive UTI. Our results demonstrate that RegIIIγ and HIP/PAP expression is induced during human and murine UTI. However, their specific function in the urinary tract remains uncertain.

  1. Expression and Significance of the HIP/PAP and RegIIIγ Antimicrobial Peptides during Mammalian Urinary Tract Infection.

    Directory of Open Access Journals (Sweden)

    John David Spencer

    Full Text Available Recent evidence indicates that antimicrobial peptides (AMPs serve key roles in defending the urinary tract against invading uropathogens. To date, the individual contribution of AMPs to urinary tract host defense is not well defined. In this study, we identified Regenerating islet-derived 3 gamma (RegIIIγ as the most transcriptionally up-regulated AMP in murine bladder transcriptomes following uropathogenic Escherichia coli (UPEC infection. We confirmed induction of RegIIIγ mRNA during cystitis and pyelonephritis by quantitative RT-PCR. Immunoblotting demonstrates increased bladder and urinary RegIIIγ protein levels following UPEC infection. Immunostaining localizes RegIIIγ protein to urothelial cells of infected bladders and kidneys. Human patients with UTI have increased urine concentrations of the orthologous Hepatocarcinoma-Intestine-Pancreas / Pancreatitis Associated Protein (HIP/PAP compared to healthy controls. Recombinant RegIIIγ protein does not demonstrate bactericidal activity toward UPEC in vitro, but does kill Staphylococcus saprophyticus in a dose-dependent manner. Kidney and bladder tissue from RegIIIγ knockout mice and wild-type mice contain comparable bacterial burden following UPEC and Gram-positive UTI. Our results demonstrate that RegIIIγ and HIP/PAP expression is induced during human and murine UTI. However, their specific function in the urinary tract remains uncertain.

  2. British Sign Language.

    Science.gov (United States)

    Kyle, Jim; Woll, Bencie

    1981-01-01

    The author reports on the use of British Sign Language in the United Kingdom and dispels some myths that surround the language. It is pointed out that there is a low level of interest in deaf people and their method of communication. Research needs in the area of sign language systems are briefly considered. (SB)

  3. Sign Language Advantage.

    Science.gov (United States)

    Daniels, Marilyn

    2001-01-01

    Describes Sign in Education, a pilot program in the United Kingdom that integrated Deaf children and hearing children in a hearing classroom with a culturally Deaf teacher who taught the national curriculum in British Sign Language one afternoon a week. Explores the advantage to the Deaf community, as well as the majority culture of adopting such…

  4. Completely random signed measures

    DEFF Research Database (Denmark)

    Hellmund, Gunnar

    Completely random signed measures are defined, characterized and related to Lévy random measures and Lévy bases.......Completely random signed measures are defined, characterized and related to Lévy random measures and Lévy bases....

  5. Standardization of Sign Languages

    Science.gov (United States)

    Adam, Robert

    2015-01-01

    Over the years attempts have been made to standardize sign languages. This form of language planning has been tackled by a variety of agents, most notably teachers of Deaf students, social workers, government agencies, and occasionally groups of Deaf people themselves. Their efforts have most often involved the development of sign language books…

  6. Artefactual stripe sign

    Energy Technology Data Exchange (ETDEWEB)

    Rayner, J. [St George Hospital, Kogarah, NSW, (Australia)

    1997-09-01

    Full text: The stripe sign consist of `the presence on the perfusion image of a VQ lung scan of a stripe of perfused lung tissue between a perfusion defect and the adjacent pleural surface`. In the revised PIOPED criteria, it is predictive of the absence of pulmonary embolism in the area of the sign. This case study involved a 71-year-old woman who presented with left-sided pleuritic chest pain. The perfusion lung scan demonstrated a perfusion defect involving the left posterior and superior basal segments with an associated stripe sign. A repeat LPO view at a more posterior angle and tomography of the lungs failed to demonstrate the stripe. In this case, the stripe sign was an artefact, perhaps `shine through` from the underlying lung. This evidence suggests that before the stripe sign is used to diagnose a patient, it should be apparent on at least two views of differing angles or on tomography.

  7. Regímenes de planificación transfronteriza: México-Estados Unidos

    Directory of Open Access Journals (Sweden)

    Sergio Peña Medina

    2011-01-01

    Full Text Available Este artículo ofrece un marco teórico conceptual aplicado a la frontera México-Estados Unidos, para abordar la planificación transfronteriza desde la óptica de los regímenes identificados, que están enfocados al manejo de recursos compartidos, a la oferta de bienes públicos y al manejo de riesgos. El argumento central gira en torno a la habilidad de ambos países para desarrollar una capacidad institucional de planificación transfronteriza. Se analiza la evolución de sus prácticas, actores y la agenda, que da como resultado la formación de regímenes de planificación transfronteriza que operan de manera simultánea.

  8. Regímenes políticos y procesos desdemocratizadores en Nicaragua y Venezuela

    Directory of Open Access Journals (Sweden)

    Armando Chaguaceda

    2015-01-01

    Full Text Available El texto analiza, desde una perspectiva comparada afín al enfoque de diversos autores, entre los que destaca la obra póstuma de Charles Tilly, los procesos y mecanismos específicos que explican la reciente evolución desdemocratizadora de los regímenes políticos nicaragüense y venezolano. 

  9. Conformational Dynamics of Response Regulator RegX3 from Mycobacterium tuberculosis.

    Directory of Open Access Journals (Sweden)

    Ashfaq Ahmad

    Full Text Available Two-component signal transduction systems (TCS are vital for adaptive responses to various environmental stresses in bacteria, fungi and even plants. A TCS typically comprises of a sensor histidine kinase (SK with its cognate response regulator (RR, which often has two domains-N terminal receiver domain (RD and C terminal effector domain (ED. The histidine kinase phosphorylates the RD to activate the ED by promoting dimerization. However, despite significant progress on structural studies, how RR transmits activation signal from RD to ED remains elusive. Here we analyzed active to inactive transition process of OmpR/PhoB family using an active conformation of RegX3 from Mycobacterium tuberculosis as a model system by computational approaches. An inactive state of RegX3 generated from 150 ns molecular dynamic simulation has rotameric conformations of Thr79 and Tyr98 that are generally conserved in inactive RRs. Arg81 in loop β4α4 acts synergistically with loop β1α1 to change its interaction partners during active to inactive transition, potentially leading to the N-terminal movement of RegX3 helix α1. Global conformational dynamics of RegX3 is mainly dependent on α4β5 region, in particular seven 'hot-spot' residues (Tyr98 to Ser104, adjacent to which several coevolved residues at dimeric interface, including Ile76-Asp96, Asp97-Arg111 and Glu24-Arg113 pairs, are critical for signal transduction. Taken together, our computational analyses suggest a molecular linkage between Asp phosphorylation, proximal loops and α4β5α5 dimeric interface during RR active to inactive state transition, which is not often evidently defined from static crystal structures.

  10. Correcting image placement errors using registration control (RegC®) technology in the photomask periphery

    Science.gov (United States)

    Cohen, Avi; Lange, Falk; Ben-Zvi, Guy; Graitzer, Erez; Vladimir, Dmitriev

    2012-11-01

    The ITRS roadmap specifies wafer overlay control as one of the major tasks for the sub 40 nm nodes in addition to CD control and defect control. Wafer overlay is strongly dependent on mask image placement error (registration errors or Reg errors)1. The specifications for registration or mask placement accuracy are significantly tighter in some of the double patterning techniques (DPT). This puts a heavy challenge on mask manufacturers (mask shops) to comply with advanced node registration specifications. The conventional methods of feeding back the systematic registration error to the E-beam writer and re-writing the mask are becoming difficult, expensive and not sufficient for the advanced nodes especially for double pattering technologies. Six production masks were measured on a standard registration metrology tool and the registration errors were calculated and plotted. Specially developed algorithm along with the RegC Wizard (dedicated software) was used to compute a correction lateral strain field that would minimize the registration errors. This strain field was then implemented in the photomask bulk material using an ultra short pulse laser based system. Finally the post process registration error maps were measured and the resulting residual registration error field with and without scale and orthogonal errors removal was calculated. In this paper we present a robust process flow in the mask shop which leads up to 32% registration 3sigma improvement, bringing some out-of-spec masks into spec, utilizing the RegC® process in the photomask periphery while leaving the exposure field optically unaffected.

  11. The reg4 gene, amplified in the early stages of pancreatic cancer development, is a promising therapeutic target.

    Directory of Open Access Journals (Sweden)

    Aude Legoffic

    Full Text Available BACKGROUND: The aim of our work was to identify the genes specifically altered in pancreatic adenocarcinoma and especially those that are altered early in cancer development. METHODOLOGY/PRINCIPAL FINDINGS: Gene copy number was systematically assessed with an ultra-high resolution CGH oligonucleotide microarray in DNA from samples of pancreatic cancer. Several new cancer-associated variations were observed. In this work we focused on one of them, involving the reg4 gene. Gene copy number gain of the reg4 gene was confirmed by qPCR in 14 cancer samples. It was also found with increased copy number in most PanIN3 samples. The relationship betweena gain in reg4 gene copy number and cancer development was investigated on the human pancreatic cancer cell line Mia-PaCa2 xenografted under the skin of nude mice. When cells were transfected with a vector allowing reg4 expression, they generated tumors almost twice larger in size. In addition, these tumors were more resistant to gemcitabine treatment than control tumors. Interestingly, weekly intraperitoneal administration of a monoclonal antibody to reg4 halved the size of tumors generated by Mia-PaCa2 cells, suggesting that the antibody interfered with a paracrine/autocrine mechanism involving reg4 and stimulating cancer progression. The addition of gemcitabine resulted in further reduction, tumors becoming 5 times smaller than control. Exposure to reg4 antibody resulted in a significant decrease in intra-tumor levels of pAkt, Bcl-xL, Bcl-2, survivin and cyclin D1. CONCLUSIONS/SIGNIFICANCE: It was concluded that adjuvant therapies targeting reg4 could improve the standard treatment of pancreatic cancer with gemcitabine.

  12. Dermatomyositis: Signs and Symptoms

    Science.gov (United States)

    ... Meet our Partners How to Get Involved Donate Dermatomyositis (DM) Share print email share facebook twitter google ... Signs and Symptoms What happens to someone with dermatomyositis? For many decades, DM was considered “ polymyositis with ...

  13. Signs of Overload

    Science.gov (United States)

    ... Listen Text Size Email Print Share Signs of Overload Page Content Article Body Although stress is a ... 12 (Copyright © 2004 American Academy of Pediatrics) The information contained on this Web site should not be ...

  14. Pertussis Signs & Symptoms

    Science.gov (United States)

    ... of Kids with Infectious Diseases (PKIDs) Signs and Symptoms Language: English Español (Spanish) Recommend on Facebook Tweet ... not for as long as 3 weeks. Early Symptoms In those who have been vaccinated: In most ...

  15. The Bactericidal Lectin RegIIIβ Prolongs Gut Colonization and Enteropathy in the Streptomycin Mouse Model for Salmonella Diarrhea.

    Science.gov (United States)

    Miki, Tsuyoshi; Goto, Ryosuke; Fujimoto, Mayuka; Okada, Nobuhiko; Hardt, Wolf-Dietrich

    2017-02-08

    The bactericidal lectin RegIIIβ is inducibly produced by intestinal epithelial cells as a defense against infection by enteropathogens. In the gut lumen, RegIIIβ kills not only certain enteropathogens, but also some commensal bacteria; thus, RegIIIβ is also thought to be an innate immune effector shaping microbiota composition and establishing intestinal homeostasis. Using the streptomycin mouse model for Salmonella colitis, we show that RegIIIβ can promote sustained gut colonization of Salmonella Typhimurium and prolong enteropathy. RegIIIβ expression was associated with suppression of Bacteroides spp. in the gut lumen, prolonged disease-associated alterations in colonic metabolism, and reduced luminal vitamin B6 levels. Supplementation with Bacteroides spp. or vitamin B6 accelerated pathogen clearance from the gut and remission of enteropathy. Our findings indicate that interventions at the level of RegIIIβ and supplementation with Bacteroides spp. or vitamin B6 might open new avenues for therapeutic intervention in the context of Salmonella colitis. Copyright © 2017 Elsevier Inc. All rights reserved.

  16. The Babinski sign.

    Science.gov (United States)

    Morrow, Jasper M; Reilly, Mary M

    2011-10-01

    Joseph Babinski (1857-1932), a French neurologist of Polish descent, was the first person to describe extension of the big toe following stimulation of the sole of the foot on 22 February 1896 (Babinski, 1896). He referred to the sign as 'phénomène des orteils' (toes phenomenon) but it is now usually referred to eponymously as the 'Babinski sign' or descriptively as the extensor plantar response.

  17. Pancreatic stone protein/regenerating protein (PSP/reg): a novel secreted protein up-regulated in type 2 diabetes mellitus.

    Science.gov (United States)

    Yang, Jiayue; Li, Ling; Raptis, Dimitri; Li, Xiaoshan; Li, Fengfei; Chen, Bijun; He, Jiajia; Graf, Rolf; Sun, Zilin

    2015-04-01

    Type 2 diabetes mellitus (T2DM) has insulin resistance (IR) or reduced β-cell mass, partially due to an increased β-cell apoptosis rate. Pancreatic stone protein/regenerating protein (PSP/reg) is a secretory protein produced in the pancreas and up-regulated dramatically during pancreatic disease. Recent studies revealed that β-cells undergoing apoptosis induce PSP/reg expression in surviving neighboring cells. Further experiments demonstrated that PSP/reg was elevated during disease progression in type 1 diabetes mellitus (T1DM). However, the association between PSP/reg and T2DM patients is unknown. The aim of this pilot study was to investigate PSP/reg in different clinical stages of T2DM and evaluate its correlation with chronic complications of diabetes. A total of 1,121 participants (479 males, 642 females; age range 23-80 years) were enrolled in this study. PSP/reg serum values were measured by a newly developed enzyme-linked immunosorbent assay (ELISA). We analyzed its correlation with clinical and biochemical parameters in subjects with T2DM at different clinical phases. Statistical analyses were conducted using SPSS 17.0 software. Correlations of PSP/reg and clinical parameters were performed using Spearman's rank correlation coefficient. Differences between groups were determined by Nemenyi test. PSP/reg was elevated in high-risk and impaired glucose regulation (IGR) patients (pPSP/reg was significantly up-regulated in newly diagnosed T2DM patients and long-term diabetes patients with complications (pPSP/reg levels correlated with the duration of diabetes (pPSP/reg is significantly up-regulated in T2DM patients, and PSP/reg levels are related to the duration of diabetes. Therefore, PSP/reg might be useful as a predictor of T2DM and disease progression.

  18. Helicobacter pylori CagA triggers expression of the bactericidal lectin REG3γ via gastric STAT3 activation.

    Directory of Open Access Journals (Sweden)

    Kai Syin Lee

    Full Text Available BACKGROUND: Most of what is known about the Helicobacter pylori (H. pylori cytotoxin, CagA, pertains to a much-vaunted role as a determinant of gastric inflammation and cancer. Little attention has been devoted to potential roles of CagA in the majority of H. pylori infected individuals not showing oncogenic progression, particularly in relation to host tolerance. Regenerating islet-derived (REG3γ encodes a secreted C-type lectin that exerts direct bactericidal activity against Gram-positive bacteria in the intestine. Here, we extend this paradigm of lectin-mediated innate immunity, showing that REG3γ expression is triggered by CagA in the H. pylori-infected stomach. METHODOLOGY/PRINCIPAL FINDINGS: In human gastric mucosal tissues, REG3γ expression was significantly increased in CagA-positive, compared to CagA-negative H. pylori infected individuals. Using transfected CagA-inducible gastric MKN28 cells, we recapitulated REG3γ induction in vitro, also showing that tyrosine phosphorylated, not unphosphorylated CagA triggers REG3γ transcription. In concert with induced REG3γ, pro-inflammatory signalling downstream of the gp130 cytokine co-receptor via the signal transducer and activator of transcription (STAT3 and transcription of two cognate ligands, interleukin(IL-11 and IL-6, were significantly increased. Exogenous IL-11, but not IL-6, directly stimulated STAT3 activation and REG3γ transcription. STAT3 siRNA knockdown or IL-11 receptor blockade respectively abrogated or subdued CagA-dependent REG3γ mRNA induction, thus demonstrating a requirement for uncompromised signalling via the IL-11/STAT3 pathway. Inhibition of the gp130-related SHP2-(Ras-ERK pathway did not affect CagA-dependent REG3γ induction, but strengthened STAT3 activation as well as augmenting transcription of mucosal innate immune regulators, IL-6, IL-8 and interferon-response factor (IRF1. CONCLUSIONS/SIGNIFICANCE: Our results support a model of CagA-directed REG3

  19. Computational triadic algebras of signs

    Energy Technology Data Exchange (ETDEWEB)

    Zadrozny, W. [T.J. Watson Research Center, Yorktown Heights, NY (United States)

    1996-12-31

    We present a finite model of Peirce`s ten classes of signs. We briefly describe Peirce`s taxonomy of signs; we prove that any finite collection of signs can be extended to a finite algebra of signs in which all interpretants are themselves being interpreted; and we argue that Peirce`s ten classes of signs can be defined using constraints on algebras of signs. The paper opens the possibility of defining multimodal cognitive agents using Peirce`s classes of signs, and is a first step towards building a computational logic of signs based on Peirce`s taxonomies.

  20. Signs In Place

    DEFF Research Database (Denmark)

    Hamid, Salmiah Binti Abdul; Jensen, Ole B.; Silva, Victor

    2012-01-01

    Travelling in unfamiliar areas is usually very interesting; however, it can also be stressful. People travel or move around in an urban space according to their needs, and the environment can influence the way people move about from one place to another. If a person gets lost, a map or GPS can...... be an effective guidance tool. However, “signs in place” offer alternative or additional guidelines to help people with their journey. This paper, first, seeks to understand road traffic signs in terms of mobility in everyday life. It, then, attempts to distinguish the different perspectives of mobility...... and geosemiotic studies with regards to the road traffic signs used in urban spaces. The paper ends with a discussion on how people choreograph their movement in their everyday life from two different perspectives: above vs. below...

  1. Signs in Place

    DEFF Research Database (Denmark)

    Hamid, Salmiah Binti Abdul; Jensen, Ole B.; Silva, Victor

    Travelling in unfamiliar areas is usually very interesting, however it can also be stressful. People travel or move around in an urban space according to their needs, and the environment can also influence the way people move about from one place to another. If a person gets lost, a map or GPS can...... be an effective guidance tool. However, “signs in place” offer alternative or additional guidelines to help people with their journey. This paper firstly seeks to understand road traffic signs in terms of mobility in everyday life. It then attempts to distinguish the different perspectives of mobility...... and geosemiotic studies with regards to the road traffic signs used in urban spaces. The paper ends with a discussion on how people choreograph their movement in their everyday life from two different perspectives: above vs. below....

  2. Babinski and Babinski sign.

    Science.gov (United States)

    Bassetti, C

    1995-12-01

    Babinski's sign probably is the best known neurologic eponym, referring to dorsiflexion of the great toe with or without fanning of the other toes and withdrawal of the leg. This follows plantar stimulation in patients with pyramidal tract dysfunction. Although the plantar reflex already had been described, Babinski--a French neurologist of Polish descent and a pupil of Charcot--was the first to differentiate between a normal and pathologic response of the toes and recognize its clinical implication. Despite the continuing controversy over its pathophysiologic interpretation, the clinical utility of Babinski's sign remains unchanged almost 100 years after its description.

  3. Toward the Ideal Signing Avatar

    Directory of Open Access Journals (Sweden)

    Nicoletta Adamo-Villani

    2016-06-01

    Full Text Available The paper discusses ongoing research on the effects of a signing avatar's modeling/rendering features on the perception of sign language animation. It reports a recent study that aimed to determine whether a character's visual style has an effect on how signing animated characters are perceived by viewers. The stimuli of the study were two polygonal characters presenting two different visual styles: stylized and realistic. Each character signed four sentences. Forty-seven participants with experience in American Sign Language (ASL viewed the animated signing clips in random order via web survey. They (1 identified the signed sentences (if recognizable, (2 rated their legibility, and (3 rated the appeal of the signing avatar. Findings show that while character's visual style does not have an effect on subjects' perceived legibility of the signs and sign recognition, it has an effect on subjects' interest in the character. The stylized signing avatar was perceived as more appealing than the realistic one.

  4. Evaluation of Boulder, CO,SmartRegs Ordinance and Better Buildings Program

    Energy Technology Data Exchange (ETDEWEB)

    Arena, L. [Consortium for Advanced Residential Buildings (CARB), Norwalk, CT (United States); Vijayakumar, G. [Consortium for Advanced Residential Buildings (CARB), Norwalk, CT (United States)

    2012-04-01

    Under the SmartRegs ordinance in the city of Boulder, Colorado, all rental properties in the city must achieve an energy efficiency level comparable to a HERS Index of approximately 120 points or lower by the year 2019. The City of Boulder received a $12 million grant from the DOE’s Better Buildings initiative to create and incentivize their EnergySmart Program. In this report, the Consortium for Advanced Residential Buildings (CARB) describes its work with the program, including energy audits of rental properties, developing training programs for insulators and inspectors, and conducting interviews with property owners.

  5. Evaluation of Boulder, CO, SmartRegs Ordinance and Better Buildings Program

    Energy Technology Data Exchange (ETDEWEB)

    Arena, L.; Vijayakumar, G.

    2012-04-01

    Under the SmartRegs ordinance in the city of Boulder, Colorado, all rental properties in the city must achieve an energy efficiency level comparable to a HERS Index of approximately 120 points or lower by the year 2019. The City of Boulder received a $12 million grant from the DOE's Better Buildings initiative to create and incentivize their EnergySmart Program. In this report, the Consortium for Advanced Residential Buildings (CARB) describes its work with the program, including energy audits of rental properties, developing training programs for insulators and inspectors, and conducting interviews with property owners.

  6. The ivy sign

    Directory of Open Access Journals (Sweden)

    Nasreen Mahomed

    2014-04-01

    Full Text Available The ivy sign refers to diffuse bilateral leptomeningeal enhancement on post- contrastT1-weighted magnetic resonance imaging (MRI and increased signal intensity in bilateralsubarachnoid spaces and perivascular spaces on T2-weighted fluid attenuation inversionrecovery (FLAIR MRI sequences in patients with moyamoya disease.

  7. Flemish Sign Language Standardisation

    Science.gov (United States)

    Van Herreweghe, Mieke; Vermeerbergen, Myriam

    2009-01-01

    In 1997, the Flemish Deaf community officially rejected standardisation of Flemish Sign Language. It was a bold choice, which at the time was not in line with some of the decisions taken in the neighbouring countries. In this article, we shall discuss the choices the Flemish Deaf community has made in this respect and explore why the Flemish Deaf…

  8. Signing in Science

    Science.gov (United States)

    Ashby, Rachael

    2013-01-01

    This article describes British Sign Language (BSL) as a viable option for teaching science. BSL is used by a vast number of people in Britain but is seldom taught in schools or included informally alongside lessons. With its new addition of a large scientific glossary, invented to modernise the way science is taught to deaf children, BSL breaks…

  9. Buffer Zone Sign Template

    Science.gov (United States)

    The certified pesticide applicator is required to post a comparable sign, designating a buffer zone around the soil fumigant application block in order to control exposure risk. It must include the don't walk symbol, product name, and applicator contact.

  10. Derivative Sign Patterns

    Science.gov (United States)

    Clark, Jeffrey

    2011-01-01

    Analysis of the patterns of signs of infinitely differentiable real functions shows that only four patterns are possible if the function is required to exhibit the pattern at all points in its domain and that domain is the set of all real numbers. On the other hand all patterns are possible if the domain is a bounded open interval.

  11. Derivative Sign Patterns

    Science.gov (United States)

    Clark, Jeffrey

    2011-01-01

    Analysis of the patterns of signs of infinitely differentiable real functions shows that only four patterns are possible if the function is required to exhibit the pattern at all points in its domain and that domain is the set of all real numbers. On the other hand all patterns are possible if the domain is a bounded open interval.

  12. Sign Language Web Pages

    Science.gov (United States)

    Fels, Deborah I.; Richards, Jan; Hardman, Jim; Lee, Daniel G.

    2006-01-01

    The World Wide Web has changed the way people interact. It has also become an important equalizer of information access for many social sectors. However, for many people, including some sign language users, Web accessing can be difficult. For some, it not only presents another barrier to overcome but has left them without cultural equality. The…

  13. The Sign of Love

    Institute of Scientific and Technical Information of China (English)

    司亮

    2009-01-01

    @@ 一、故事内容 Mr Rabbit and Mr Wolf are neighbors.Mr Rabbit has many friends,but Mr Wolf has none.One day Mr Wolf wants to know the truth.He asks a lot of anitmals and finds the secret:it is a red paper heart.They all call it"the sign of love".

  14. These signs here now

    DEFF Research Database (Denmark)

    Raudaskoski, Pirkko Liisa

    1995-01-01

    Hallidays (1984) formulations of systemic-functional linguistics together with Hodge and Kress' (1988) social semiotics share the assumption that signs are not arbitrary: People make choices out of a web of possible constructions or expressions, and those choices can be shown to be motivated...

  15. RegTransBase - A Database Of Regulatory Sequences and Interactionsin a Wide Range of Prokaryotic Genomes

    Energy Technology Data Exchange (ETDEWEB)

    Kazakov, Alexei E.; Cipriano, Michael J.; Novichkov, Pavel S.; Minovitsky, Simon; Vinogradov, Dmitry V.; Arkin, Adam; Mironov, AndreyA.; Gelfand, Mikhail S.; Dubchak, Inna

    2006-07-01

    RegTransBase, a manually curated database of regulatoryinteractions in prokaryotes, captures the knowledge in publishedscientific literature using a controlled vocabulary. Although a number ofdatabases describing interactions between regulatory proteins and theirbinding sites are currently being maintained, they focus mostly on themodel organisms Escherichia coli and Bacillus subtilis, or are entirelycomputationally derived. RegTransBase describes a large number ofregulatory interactions reported in many organisms and contains varioustypes of experimental data, in particular: the activation or repressionof transcription by an identified direct regulator; determining thetranscriptional regulatory function of a protein (or RNA) directlybinding to DNA (RNA); mapping or prediction of binding site for aregulatory protein; characterization of regulatory mutations. Currently,the RegTransBase content is derived from about 3000 relevant articlesdescribing over 7000 experiments in relation to 128 microbes. It containsdata on the regulation of about 7500 genes and evidence for 6500interactions with 650 regulators. RegTransBase also contains manuallycreated position weight matrices (PWM) that can be used to identifycandidate regulatory sites in over 60 species. RegTransBase is availableat http://regtransbase.lbl.gov.

  16. Wrong Signs in Regression Coefficients

    Science.gov (United States)

    McGee, Holly

    1999-01-01

    When using parametric cost estimation, it is important to note the possibility of the regression coefficients having the wrong sign. A wrong sign is defined as a sign on the regression coefficient opposite to the researcher's intuition and experience. Some possible causes for the wrong sign discussed in this paper are a small range of x's, leverage points, missing variables, multicollinearity, and computational error. Additionally, techniques for determining the cause of the wrong sign are given.

  17. Manual Signing in Adults with Intellectual Disability: Influence of Sign Characteristics on Functional Sign Vocabulary

    Science.gov (United States)

    Meuris, Kristien; Maes, Bea; De Meyer, Anne-Marie; Zink, Inge

    2014-01-01

    Purpose: The purpose of this study was to investigate the influence of sign characteristics in a key word signing (KWS) system on the functional use of those signs by adults with intellectual disability (ID). Method: All 507 signs from a Flemish KWS system were characterized in terms of phonological, iconic, and referential characteristics.…

  18. Visual Signs of Ageing

    Directory of Open Access Journals (Sweden)

    Helle Rexbye

    2007-07-01

    Full Text Available Consumer culture has placed the ageing body in a dilemma of representation. Physical appearance has become increasingly important as a symbol of identity, and at the same time society idealizes youth. This study explores visual ageing empirically. By using photographs of older persons (70+ as starting point, it is explored how visual age is assessed and interpreted. It is shown that informants read age in a spread of stages and categories. Main age indicators are biological markers: skin, eyes, and hair colour, but supplemented by vigour, style, and grooming. Furthermore, in-depth interviews indicate that visual age is mainly interpreted into categories and moral regulations rooted in early modernity. Subsequently the question of a postmodern perspective of visual ageing is discussed in this article. The empirical findings in the study question a postmodern fluidity of visual signs – at least when the concern is signs of ageing.

  19. The Integral Sign Galaxy

    Science.gov (United States)

    Noll, Keith

    2007-07-01

    We will observe the unusual warped disk galaxy known as the Integral Sign Galaxy, UGC 3697, with a small two-position WFPC2 mosaic. Observations will be obtained in three broad band filters and the resulting image will be released on the 19th anniversary of the launch of the Hubble Space Telescope on ~April 24, 2009. Multidrizzled mosaics will be made available through the archive.

  20. Planetary Vital Signs

    Science.gov (United States)

    Kennel, Charles; Briggs, Stephen; Victor, David

    2016-07-01

    The climate is beginning to behave in unusual ways. The global temperature reached unprecedented highs in 2015 and 2016, which led climatologists to predict an enormous El Nino that would cure California's record drought. It did not happen the way they expected. That tells us just how unreliable temperature has become as an indicator of important aspects of climate change. The world needs to go beyond global temperature to a set of planetary vital signs. Politicians should not over focus policy on one indicator. They need to look at the balance of evidence. A coalition of scientists and policy makers should start to develop vital signs at once, since they should be ready at the entry into force of the Paris Agreement in 2020. But vital signs are only the beginning. The world needs to learn how to use the vast knowledge we will be acquiring about climate change and its impacts. Is it not time to use all the tools at hand- observations from space and ground networks; demographic, economic and societal measures; big data statistical techniques; and numerical models-to inform politicians, managers, and the public of the evolving risks of climate change at global, regional, and local scales? Should we not think in advance of an always-on social and information network that provides decision-ready knowledge to those who hold the responsibility to act, wherever they are, at times of their choosing?

  1. The Danish Sign Language Dictionary

    DEFF Research Database (Denmark)

    Kristoffersen, Jette Hedegaard; Troelsgård, Thomas

    2010-01-01

    The entries of the The Danish Sign Language Dictionary have four sections:  Entry header: In this section the sign headword is shown as a photo and a gloss. The first occurring location and handshape of the sign are shown as icons.  Video window: By default the base form of the sign headword...... forms of the sign (only for classifier entries). In addition to this, frequent co-occurrences with the sign are shown in this section. The signs in the The Danish Sign Language Dictionary can be looked up through:  Handshape: Particular handshapes for the active and the passive hand can be specified...... to find signs that are not themselves lemmas in the dictionary, but appear in example sentences.  Topic: Topics can be chosen as search criteria from a list of 70 topics....

  2. Green's Theorem for Sign Data

    OpenAIRE

    Louis M. Houston

    2012-01-01

    Sign data are the signs of signal added to noise. It is well known that a constant signal can be recovered from sign data. In this paper, we show that an integral over variant signal can be recovered from an integral over sign data based on the variant signal. We refer to this as a generalized sign data average. We use this result to derive a Green's theorem for sign data. Green's theorem is important to various seismic processing methods, including seismic migration. Results in this paper ge...

  3. Sign language perception research for improving automatic sign language recognition

    Science.gov (United States)

    ten Holt, Gineke A.; Arendsen, Jeroen; de Ridder, Huib; Koenderink-van Doorn, Andrea J.; Reinders, Marcel J. T.; Hendriks, Emile A.

    2009-02-01

    Current automatic sign language recognition (ASLR) seldom uses perceptual knowledge about the recognition of sign language. Using such knowledge can improve ASLR because it can give an indication which elements or phases of a sign are important for its meaning. Also, the current generation of data-driven ASLR methods has shortcomings which may not be solvable without the use of knowledge on human sign language processing. Handling variation in the precise execution of signs is an example of such shortcomings: data-driven methods (which include almost all current methods) have difficulty recognizing signs that deviate too much from the examples that were used to train the method. Insight into human sign processing is needed to solve these problems. Perceptual research on sign language can provide such insights. This paper discusses knowledge derived from a set of sign perception experiments, and the application of such knowledge in ASLR. Among the findings are the facts that not all phases and elements of a sign are equally informative, that defining the 'correct' form for a sign is not trivial, and that statistical ASLR methods do not necessarily arrive at sign representations that resemble those of human beings. Apparently, current ASLR methods are quite different from human observers: their method of learning gives them different sign definitions, they regard each moment and element of a sign as equally important and they employ a single definition of 'correct' for all circumstances. If the object is for an ASLR method to handle natural sign language, then the insights from sign perception research must be integrated into ASLR.

  4. Sign Language Comprehension: The Case of Spanish Sign Language

    Science.gov (United States)

    Rodriguez Ortiz, I. R.

    2008-01-01

    This study aims to answer the question, how much of Spanish Sign Language interpreting deaf individuals really understand. Study sampling included 36 deaf people (deafness ranging from severe to profound; variety depending on the age at which they learned sign language) and 36 hearing people who had good knowledge of sign language (most were…

  5. Sign language typology: The contribution of rural sign languages

    NARCIS (Netherlands)

    C. de Vos; R. Pfau

    2014-01-01

    Since the 1990s, the field of sign language typology has shown that sign languages exhibit typological variation at all relevant levels of linguistic description. These initial typological comparisons were heavily skewed toward the urban sign languages of developed countries, mostly in the Western w

  6. American Sign Language and Pidgin Sign English: What's the Difference?

    Science.gov (United States)

    Reilly, Judy; McIntire, Marina L.

    1980-01-01

    The differences between Pidgin Sign English and American Sign Language in simultaneity, or the visible presence of two or more linguistic units (manual or nonmanual) co-occurring, are demonstrated. Differences are exemplified in handshape-classifier pronouns, directional verbs, co-occurring manual signs, and nonmanual behavior. (PMJ)

  7. Refuting the lipstick sign.

    Science.gov (United States)

    Grassbaugh, Jason A; Bean, Betsey R; Greenhouse, Alyssa R; Yu, Henry H; Arrington, Edward D; Friedman, Richard J; Eichinger, Josef K

    2017-08-01

    Arthroscopic examination of the tendon has been described as the "gold standard" for diagnosis of tendinitis of the long head of the biceps (LHB). An arthroscopic finding of an inflamed and hyperemic LHB within the bicipital groove has been described as the "lipstick sign." Studies evaluating direct visualization in diagnosis of LHB tendinitis are lacking. During a 1-year period, 363 arthroscopic shoulder procedures were performed, with 16 and 39 patients prospectively selected as positive cases and negative controls, respectively. All positive controls had groove tenderness, positive Speed maneuver, and diagnostic ultrasound-guided bicipital injection. Negative controls had none of these findings. Six surgeons reviewed randomized deidentified arthroscopic pictures of enrolled patients The surgeons were asked whether the images demonstrated LHB tendinitis and if the lipstick sign was present. Overall sensitivity and specificity were 49% and 66%, respectively, for detecting LHB tendinitis and 64% and 31%, respectively, for erythema. The nonweighted κ score for interobserver reliability ranged from 0.042 to 0.419 (mean, 0.215 ± 0.116) for tendinitis and from 0.486 to 0.835 (mean, 0.680 ± 0.102) for erythema. The nonweighted κ score for intraobserver reliability ranged from 0.264 to 0.854 (mean, 0.615) for tendinitis and from 0.641 to 0.951 (mean, 0.783) for erythema. The presence of the lipstick sign performed only moderately well in a rigorously designed level III study to evaluate its sensitivity and specificity. There is only fair agreement among participating surgeons in diagnosing LHB tendinitis arthroscopically. Consequently, LHB tendinitis requiring tenodesis remains a clinical diagnosis that should be made before arthroscopic examination. Published by Elsevier Inc.

  8. Signs In Place

    DEFF Research Database (Denmark)

    Hamid, Salmiah Binti Abdul; Jensen, Ole B.; Silva, Victor

    2012-01-01

    Travelling in unfamiliar areas is usually very interesting; however, it can also be stressful. People travel or move around in an urban space according to their needs, and the environment can influence the way people move about from one place to another. If a person gets lost, a map or GPS can...... and geosemiotic studies with regards to the road traffic signs used in urban spaces. The paper ends with a discussion on how people choreograph their movement in their everyday life from two different perspectives: above vs. below...

  9. Differentiation of ICOS+ and ICOS- recent thymic emigrant regulatory T cells (RTE T regs) during normal pregnancy, pre-eclampsia and HELLP syndrome.

    Science.gov (United States)

    Wagner, M I; Jöst, M; Spratte, J; Schaier, M; Mahnke, K; Meuer, S; Zeier, M; Steinborn, A

    2016-01-01

    Two different subsets of naturally occurring regulatory T cells (nTregs), defined by their expression of the inducible co-stimulatory (ICOS) molecule, are produced by the human thymus. To examine the differentiation of ICOS(+) and ICOS(-) CD45RA(+) CD31(+) recent thymic emigrant (RTE) T regs during normal pregnancy and in the presence of pre-eclampsia or haemolysis elevated liver enzymes low platelet (HELLP)-syndrome, we used six-colour flow cytometric analysis to determine the changes in the composition of the ICOS(+) and ICOS(-) T reg pools with CD45RA(+) CD31(+) RTE T regs, CD45RA(+) CD31(-) mature naive (MN) T regs, CD45RA(-) CD31(+) and CD45RA(-) CD31(-) memory Tregs. With the beginning of pregnancy until term, we observed a strong differentiation of both ICOS(+) and ICOS(-) CD45RA(+) CD31(+) RTE, but not CD45RA(+) CD31(-) MN T regs, into CD45RA(-) CD31(-) memory T regs. At the end of pregnancy, the onset of spontaneous term labour was associated with a significant breakdown of ICOS(+) CD45RA(-) CD31(-) memory T regs. However, in the presence of pre-eclampsia, there was a significantly increased differentiation of ICOS(+) and ICOS(-) CD45RA(+) CD31(+) RTE T regs into CD45RA(-) CD31(+) memory T regs, wherein the lacking differentiation into CD45RA(-) CD31(-) memory T regs was partially replaced by the increased differentiation of ICOS(+) and ICOS(-) CD45RA(+) CD31(-) MN Tregs into CD45RA(-) CD31(-) memory T regs. In patients with HELLP syndrome, this alternatively increased differentiation of CD45RA(-) CD31(-) MN T regs seemed to be exaggerated, and presumably restored the suppressive activity of magnetically isolated ICOS(+) and ICOS(-) T regs, which were shown to be significantly less suppressive in pre-eclampsia patients, but not in HELLP syndrome patients. Hence, our findings propose that the regular differentiation of both ICOS(+) and ICOS(-) CD45RA(+) CD31(+) RTE T regs ensures a healthy pregnancy course, while their disturbed differentiation is

  10. Puusepp's sign--clinical significance of a forgotten pyramidal sign.

    Science.gov (United States)

    Tacik, Pawel; Krasnianski, M; Zierz, S

    2009-12-01

    The pyramidal signs in the lower extremity can be divided into three groups: (1) Babinski's group characterised by dorsoflexion of the great toe, (2) pyramidal signs marked by plantar flexion of the toes (e.g. Rossolimo's sign), and (3) synkinetic movements such as Strümpell's phenomenon. Puusepp's sign described by the Estonian neurologist and neurosurgeon Ludvig Puusepp belongs to none of these three groups. Its eliciting does not differ from that of Babinski's sign. The response, however, is different and consists of a tonic slow abduction of the little toe. We showed its relevance on the basis of clinical examination of six patients: four females aged 29, 50, 43 and 57 years and two males aged 42 and 49 years. The diagnoses were as follows: a new relapse of multiple sclerosis, a secondary progressive multiple sclerosis, a left middle cerebral artery stroke, a lumbago resulting in L3-L4 fusion surgery, an amyotrophic lateral sclerosis and a left intracerebral haemorrhage respectively. Puusepp's sign was the only elicitable pyramidal sign in all the patients but two. The 50-year-old female patient revealed on neurological examination Babinski's sign on the left side and Puusepp's sign on the right side. The testing of pyramidal signs in the 57-year-old woman displayed a bilateral Strümpell's sign and a left Puusepp's sign. These six cases showed that although rarely recognized in the clinical practice Puusepp's sign contributed to establishing the diagnosis of a central motor neuron involvement in the case of an absent Babinski's sign. Thus, its testing does not differ from that of Babinski's sign which requires only a little attention from the examiner, but provides an important piece of clinical information.

  11. INFINITY construction contract signed

    Science.gov (United States)

    2010-01-01

    Key state and community leaders celebrated April 6 with the signing of a construction contract for the state-of-the-art INFINITY Science Center planned near John C. Stennis Space Center in south Mississippi. Gulfport Mayor George Schloegel (l to r), chair of non-profit INFINITY Science Center Inc., was joined for the signing ceremony at the Hancock Bank in Gulfport by Virginia Wagner, sister of late Hancock Bank President Leo Seal Jr.; and Roy Anderson III, president and CEO of Roy Anderson Corp. Seal was the first chair of INFINITY Science Center Inc., which has led in development of the project. Roy Anderson Corp. plans to begin construction on the 72,000-square-foot, $28 million science and education center in May. The Mississippi Department of Transportation (MDOT) also is set to begin construction of a $2 million access road to the new center. The April 6 ceremony was attended by numerous officials, including former Stennis Space Center Directors Jerry Hlass and Roy Estess; Mississippi Senate President Pro Tempore Billy Hewes, R-Gulfport; Mississippi Rep. Diane Peranich, D-Pass Christian; and MDOT Southern District Commissioner Wayne Brown.

  12. Comparando regímenes de bienestar en América Latina

    Directory of Open Access Journals (Sweden)

    Alejandro H. Del Valle

    2010-04-01

    Full Text Available Comparing social welfare systems in Latin America  The present work develops the principal characteristics that the studies on Latin-Americans welfare regimens have. To do this, the paper makes an analysis of the various approaches in order to examine their contributions and limitations. Finally, the paper expresses the need to further explore the productive dimension that the Latin American welfare systems present.  Resumen:  En el presente trabajo se exponen las principales características que comparten los estudios sobre regímenes de bienestar en América Latina. Para ello, se realiza un análisis de diversas contribuciones con el objeto de examinar sus aportes y limitaciones. Por último, se expresa la necesidad de profundizar la dimensión productiva que presentan los sistemas de bienestar social latinoamericanos.

  13. Kinship in Mongolian Sign Language

    Science.gov (United States)

    Geer, Leah

    2011-01-01

    Information and research on Mongolian Sign Language is scant. To date, only one dictionary is available in the United States (Badnaa and Boll 1995), and even that dictionary presents only a subset of the signs employed in Mongolia. The present study describes the kinship system used in Mongolian Sign Language (MSL) based on data elicited from…

  14. Issues in Sign Language Lexicography

    DEFF Research Database (Denmark)

    Zwitserlood, Inge; Kristoffersen, Jette Hedegaard; Troelsgård, Thomas

    2013-01-01

    ge lexicography has thus far been a relatively obscure area in the world of lexicography. Therefore, this article will contain background information on signed languages and the communities in which they are used, on the lexicography of sign languages, the situation in the Netherlands as well...... as a review of a sign language dictionary that has recently been published in the Netherlands...

  15. 3 CFR - Presidential Signing Statements

    Science.gov (United States)

    2010-01-01

    ... issued statements addressing constitutional or other legal questions upon signing bills into law (signing... of the use of signing statements to raise constitutional objections to statutory provisions. There is no doubt that the practice of issuing such statements can be abused. Constitutional...

  16. How do signs organize in directed signed social networks?

    CERN Document Server

    Guo, Long

    2016-01-01

    We introduce a reshuffled approach to empirical analyze signs' organization in real directed signed social networks of Epinions and Slashdots from the global viewpoint. In the reshuffled approach, each negative link has probability $p_{rs}$ to exchange its sign with another positive link chosen randomly. Through calculating the entropies of social status ($S_{in}$ and $S_{out}$) of and mimicking opinion formation of the majority-rule model on each reshuffled signed network, we find that $S_{in}$ and $S_{out}$ reach their own minimum values as well as the magnetization $|m^{*}|$ reaches its maximum value at $p_{rs}=0$. Namely, individuals share the homogeneous properties of social status and dynamic status in real directed signed social networks. Our present work provides some interesting tools and perspective to understand the signs' organization in signed social networks.

  17. Implementation of the NANoREG Safe-by-Design approach for different nanomaterial applications

    Science.gov (United States)

    Micheletti, C.; Roman, M.; Tedesco, E.; Olivato, I.; Benetti, F.

    2017-06-01

    The Safe-by-Design (SbD) concept is already in use in different industrial sectors as an integral part of the innovation process management. However, the adopted approach is often limited to design solutions aiming at hazard reduction. Safety is not always considered during the innovation process, mainly due to the lack of knowledge (e.g. in small and medium companies, SMEs) and the lack of dialogue between actors along the innovation chain. The net result is that safety is considered only at the end of the innovation process at the market authorization phase, with potential loss of time and money. This is especially valid for manufactured nanomaterials (MNM) for which the regulatory context is not completely developed, and the safety knowledge is not readily available. In order to contribute to a sustainable innovation process in the nanotechnology field by maximising both benefits and safety, the NANoREG project developed a Safe Innovation approach, based on two elements: the Safe-by-Design approach which aims at including risk assessment into all innovation stages; and the Regulatory Preparedness, focused on the dialogue with stakeholders along the innovation chain. In this work we present some examples about the implementation in our Laboratory of this approach for different MNM applications, covering different steps of the innovation chain. The case studies include: the feasibility study of a medical device including substances, for topical application; the testing of two potential nanotech solutions for the consolidation of cultural heritage artifacts; the testing of coatings already on the market for other uses, which was tested as food contact materials (FCM) to evaluate the conformity to food applications. These three examples represent a good opportunity to show the importance of NANoREG SbD and Safe Innovation Approach in general, for developing new nanotechnology-based products, also highlighting the crucial role of EU ProSafe project in promoting this

  18. CCISS, Vascular and BP Reg: Canadian space life science research on ISS

    Science.gov (United States)

    Hughson, Richard L.; Shoemaker, J. Kevin; Arbeille, Philippe

    2014-11-01

    A comprehensive goal of the Canadian Space Agency studies (CCISS, Vascular and BP Reg) has been to investigate the efficacy of current exercise countermeasures to maintain cardiovascular and cerebrovascular health on return to Earth after up to 6-months in space. Results from the CCISS experiments revealed no significant change of in-flight heart rate during daily activities or sleep, and small, but variable between astronauts, post-flight elevation. The between astronaut differences were exaggerated during measurement of spontaneous baroreflex slope, which was reduced post-flight (Prate of 161±46 W of 12.3±10.5 bpm, 10.4±5.9 bpm and 13.4±5.7 bpm for early-flight, late-flight and R+1, respectively. On return to gravity, changes in resting heart rate for supine (5.9±3.5 bpm), sit (8.1±3.3 bpm) and stand (10.3±10.0 bpm) were small but variable between individuals (from -5 bpm to +20 bpm in post-flight standing) and not related to the change in exercise heart rate. In Vascular astronauts, pulse wave transit time measured to the finger tended to be reduced post-flight and carotid artery distensibility was significantly reduced (P=0.03, and n=6). The heart rate and baroreflex data suggest that some astronauts return with cardiovascular deconditioning in spite of the exercise regimes. However, greater arterial stiffness is common among all astronauts studied to date. The new CSA project, BP Reg, will monitor inflight blood pressure in an attempt to identify astronauts in greater need for countermeasures. Future research should focus on whether Vascular changes in astronauts might make them an appropriate model to study the mechanisms of arterial aging on Earth.

  19. Sensitivity analysis of different parameterization schemes using RegCM4.3 for the Carpathian region

    Science.gov (United States)

    Pieczka, Ildikó; Pongrácz, Rita; Szabóné André, Karolina; Kelemen, Fanni Dóra; Bartholy, Judit

    2016-10-01

    In order to quantify the impact of the use of different parameterization schemes on regional climate model outputs, hindcast experiments have been completed applying the Regional Climate Model version 4.3 (RegCM4.3) for the Carpathian region and its surroundings at 10-km horizontal resolution with three different cumulus convection schemes. Besides, the sensitivity of outputs for subgrid-scale processes is also studied by activating the subgrid Biosphere-Atmosphere Transfer Scheme (BATS) model within other RegCM experiments. Among the analyzed factors, RegCM is most sensitive to the applied convection scheme. The impact of closure assumption related to the used convective parameterization is secondary, while the use of subgridding has less influence on the outputs. RegCM4.3 results show improved performance over our previous model simulations but still have larger amplitude for annual precipitation cycle than the measurement-based reference data. Our validation results for temperature and precipitation suggest that for the selected region, the overall best performance is achieved when using the mixed Grell-Emanuel scheme together with Fritsch and Chappell closure.

  20. CoryneRegNet 6.0--Updated database content, new analysis methods and novel features focusing on community demands.

    Science.gov (United States)

    Pauling, Josch; Röttger, Richard; Tauch, Andreas; Azevedo, Vasco; Baumbach, Jan

    2012-01-01

    Post-genomic analysis techniques such as next-generation sequencing have produced vast amounts of data about micro organisms including genetic sequences, their functional annotations and gene regulatory interactions. The latter are genetic mechanisms that control a cell's characteristics, for instance, pathogenicity as well as survival and reproduction strategies. CoryneRegNet is the reference database and analysis platform for corynebacterial gene regulatory networks. In this article we introduce the updated version 6.0 of CoryneRegNet and describe the updated database content which includes, 6352 corynebacterial regulatory interactions compared with 4928 interactions in release 5.0 and 3235 regulations in release 4.0, respectively. We also demonstrate how we support the community by integrating analysis and visualization features for transiently imported custom data, such as gene regulatory interactions. Furthermore, with release 6.0, we provide easy-to-use functions that allow the user to submit data for persistent storage with the CoryneRegNet database. Thus, it offers important options to its users in terms of community demands. CoryneRegNet is publicly available at http://www.coryneregnet.de.

  1. Spatial and Temporal Variations in Indian Summer Monsoon Rainfall and Temperature: An Analysis Based on RegCM3 Simulations

    Science.gov (United States)

    Dash, S. K.; Mamgain, Ashu; Pattnayak, K. C.; Giorgi, F.

    2013-04-01

    Regional climate models are important tools to examine the spatial and temporal characteristics of rainfall and temperature at high resolutions. Such information has potential applications in sectors like agriculture and health. In this study, the Regional Climate Model Version 3 (RegCM3) has been integrated in the ensemble mode at 55 km resolution over India for the summer monsoon season during the years 1982-2009. Emphasis has been given on the validation of the model simulation at the regional level. In Central India, both rainfall and temperature show the best correlations with respective observed values. The model gives rise to large wet biases over Northwest and Peninsular India. RegCM3 slightly underestimates the summer monsoon precipitation over the Central and Northeast India. Nevertheless, over these regions, RegCM3 simulated rainfall is closer to the observations when compared to the other regions where rainfall is overestimated. The position of the monsoon trough simulated by the model lies to the north of its original observed position. This is similar to the usual monsoon break conditions leading to less rainfall over Central India. RegCM3 simulated surface maximum temperature shows a large negative bias over the country while the surface minimum temperature is close to the observation. Nevertheless, there is a strong correlation between the all India weighted average surface temperature simulated by RegCM3 and IMD observed values. While examining the extreme weather conditions in Central India, it is found that RegCM3 simulated frequencies of occurrence of very wet days, extremely wet days, warm days and warm nights more often as compared to those in IMD observed values. However, these are systematic biases. The model biases in the frequencies of distribution of rainfall extremes explain the wet and dry biases in different regions in the country. Overall, the inter-annual characteristics of both the rainfall and temperature extremes simulated by Reg

  2. [Reverse Chaddock sign].

    Science.gov (United States)

    Tashiro, Kunio

    2011-08-01

    It is widely accepted that the Babinski reflex is the most well-known and important pathological reflex in clinical neurology. Among many other pathological reflexes that elicit an upgoing great toe, such as Chaddock, Oppenheim, Gordon, Schaefer, and Stransky, only the Chaddock reflex is said to be as sensitive as the Babinski reflex. The optimal receptive fields of the Babinski and Chaddock reflexes are the lateral plantar surface and the external inframalleolar area of the dorsum, respectively. It has been said that the Babinski reflex, obtained by stroking the sole, is by far the best and most reliable method of eliciting an upgoing great toe. However, the Chaddock reflex, the external malleolar sign, is also considered sensitive and reliable according to the literature and everyday neurological practice. The major problems in eliciting the Babinski reflex by stroking the lateral part of the sole are false positive or negative responses due to foot withdrawal, tonic foot response, or some equivocal movements. On the other hand, according to my clinical experience, the external inframalleolar area, which is the receptive field of the Chaddock reflex, is definitely suitable for eliciting the upgoing great toe. In fact, the newly proposed method to stimulate the dorsum of the foot from the medial to the lateral side, which I term the "reversed Chaddock method," is equally sensitive to demonstrate pyramidal tract involvement. With the "reversed Chaddock method", the receptive field of the Chaddock reflex may be postulated to be in the territory of the sural nerve, which could be supported by the better response obtained on stimulation of the postero-lateral calf than the anterior shin. With regard to the receptive fields of the Babinski and Chaddock reflexes, the first sacral dermatome (S1) is also considered a reflexogenous zone, but since the dermatome shows marked overlapping, the zones vary among individuals. As upgoing toe responses are consistently observed in

  3. RegPhos 2.0: an updated resource to explore protein kinase-substrate phosphorylation networks in mammals.

    Science.gov (United States)

    Huang, Kai-Yao; Wu, Hsin-Yi; Chen, Yi-Ju; Lu, Cheng-Tsung; Su, Min-Gang; Hsieh, Yun-Chung; Tsai, Chih-Ming; Lin, Kuo-I; Huang, Hsien-Da; Lee, Tzong-Yi; Chen, Yu-Ju

    2014-01-01

    Protein phosphorylation catalyzed by kinases plays crucial roles in regulating a variety of intracellular processes. Owing to an increasing number of in vivo phosphorylation sites that have been identified by mass spectrometry (MS)-based proteomics, the RegPhos, available online at http://csb.cse.yzu.edu.tw/RegPhos2/, was developed to explore protein phosphorylation networks in human. In this update, we not only enhance the data content in human but also investigate kinase-substrate phosphorylation networks in mouse and rat. The experimentally validated phosphorylation sites as well as their catalytic kinases were extracted from public resources, and MS/MS phosphopeptides were manually curated from research articles. RegPhos 2.0 aims to provide a more comprehensive view of intracellular signaling networks by integrating the information of metabolic pathways and protein-protein interactions. A case study shows that analyzing the phosphoproteome profile of time-dependent cell activation obtained from Liquid chromatography-mass spectrometry (LC-MS/MS) analysis, the RegPhos deciphered not only the consistent scheme in B cell receptor (BCR) signaling pathway but also novel regulatory molecules that may involve in it. With an attempt to help users efficiently identify the candidate biomarkers in cancers, 30 microarray experiments, including 39 cancerous versus normal cells, were analyzed for detecting cancer-specific expressed genes coding for kinases and their substrates. Furthermore, this update features an improved web interface to facilitate convenient access to the exploration of phosphorylation networks for a group of genes/proteins. Database URL: http://csb.cse.yzu.edu.tw/RegPhos2/

  4. CoryneRegNet: An ontology-based data warehouse of corynebacterial transcription factors and regulatory networks

    Directory of Open Access Journals (Sweden)

    Czaja Lisa F

    2006-02-01

    Full Text Available Abstract Background The application of DNA microarray technology in post-genomic analysis of bacterial genome sequences has allowed the generation of huge amounts of data related to regulatory networks. This data along with literature-derived knowledge on regulation of gene expression has opened the way for genome-wide reconstruction of transcriptional regulatory networks. These large-scale reconstructions can be converted into in silico models of bacterial cells that allow a systematic analysis of network behavior in response to changing environmental conditions. Description CoryneRegNet was designed to facilitate the genome-wide reconstruction of transcriptional regulatory networks of corynebacteria relevant in biotechnology and human medicine. During the import and integration process of data derived from experimental studies or literature knowledge CoryneRegNet generates links to genome annotations, to identified transcription factors and to the corresponding cis-regulatory elements. CoryneRegNet is based on a multi-layered, hierarchical and modular concept of transcriptional regulation and was implemented by using the relational database management system MySQL and an ontology-based data structure. Reconstructed regulatory networks can be visualized by using the yFiles JAVA graph library. As an application example of CoryneRegNet, we have reconstructed the global transcriptional regulation of a cellular module involved in SOS and stress response of corynebacteria. Conclusion CoryneRegNet is an ontology-based data warehouse that allows a pertinent data management of regulatory interactions along with the genome-scale reconstruction of transcriptional regulatory networks. These models can further be combined with metabolic networks to build integrated models of cellular function including both metabolism and its transcriptional regulation.

  5. Translating Signs, Producing Subjects

    Directory of Open Access Journals (Sweden)

    Brett Neilson

    2009-08-01

    Full Text Available This paper moves between two streets: Liverpool Road in the Sydney suburb of Ashfield and Via Sarpi in the Italian city of Milan. What connects these streets is that both have become important sites for businesses in the Chinese diaspora. Moreover, both are streets on which locals have expressed desires for Chinese signs to be translated into the national lingua franca. The paper argues that the cultural politics inherent in this demand for translation cannot be fully understood in the context of national debates about diversity and integration. It is also necessary to consider the emergence of the official Chinese Putonghua as global language, which competes with English but also colonizes dialects and minority languages. In the case of these dual language signs, the space between languages can neither be reduced to a contact zone of minority and majority cultures nor celebrated as a ‘third space’ where the power relations implied by such differences are subverted. At stake is rather a space characterised by what Naoki Sakai calls the schema of co-figuration, which allows the representation of translation as the passage between two equivalents that resemble each other and thus makes possible their determination as conceptually different and comparable. Drawing on arguments about translation and citizenship, the paper critically interrogates the ethos of interchangeability implied by this regime of translation. A closing argument is made for a vision of the common that implies neither civilisational harmony nor the translation of all values into a general equivalent. Primary sources include government reports, internet texts and media stories. These are analyzed using techniques of discourse analysis and interpreted with the help of secondary literature concerning globalisation, language and migration. The disciplinary matrix cuts and mixes between cultural studies, translation studies, citizenship studies, globalization studies and

  6. Negation switching invariant signed graphs

    Directory of Open Access Journals (Sweden)

    Deepa Sinha

    2014-04-01

    Full Text Available A signed graph (or, $sigraph$ in short is a graph G in which each edge x carries a value $\\sigma(x \\in \\{-, +\\}$ called its sign. Given a sigraph S, the negation $\\eta(S$ of the sigraph S is a sigraph obtained from S by reversing the sign of every edge of S. Two sigraphs $S_{1}$ and $S_{2}$ on the same underlying graph are switching equivalent if it is possible to assign signs `+' (`plus' or `-' (`minus' to vertices of $S_{1}$ such that by reversing the sign of each of its edges that has received opposite signs at its ends, one obtains $S_{2}$. In this paper, we characterize sigraphs which are negation switching invariant and also see for what sigraphs, S and $\\eta (S$ are signed isomorphic.

  7. Rigler’s sign and the football sign

    Directory of Open Access Journals (Sweden)

    Sheetal Daya

    2012-12-01

    Full Text Available Rigler’s sign was first described in 1941 by L G Rigler as a new radiological sign for recognising free air in the peritoneal cavity on supine radiograph. The presence of pneumoperitoneum allows free intraperitoneal air to be contrasted with intraluminal gas, accentuating the wall of gas-containing viscera. It is observed in infants and very ill patients where only limited radiographs of the abdomen are possible. The football sign was first described by R E Miller in the 1960s. Seen on supine abdominal radiographs, this describes an oval radiolucency resembling an American football. It is important for the radiologist to recognise the supporting signs of pneumoperitoneum, such as Rigler’s sign and the football sign, on supine abdominal radiographs, especially in neonates and infants, where erect chest/abdominal radiographs are not always possible.

  8. Ergonomics and design: traffic sign and street name sign.

    Science.gov (United States)

    Moroni, Janaina Luisa da Silva; Aymone, José Luís Farinatti

    2012-01-01

    This work proposes a design methodology using ergonomics and anthropometry concepts applied to traffic sign and street name sign projects. Initially, a literature revision on cognitive ergonomics and anthropometry is performed. Several authors and their design methodologies are analyzed and the aspects to be considered in projects of traffic and street name signs are selected and other specific aspects are proposed for the design methodology. A case study of the signs of "Street of Antiques" in Porto Alegre city is presented. To do that, interviews with the population are made to evaluate the current situation of signs. After that, a new sign proposal with virtual prototyping is done using the developed methodology. The results obtained with new interviews about the proposal show the user satisfaction and the importance of cognitive ergonomics to development of this type of urban furniture.

  9. LSE-Sign: A lexical database for Spanish Sign Language.

    Science.gov (United States)

    Gutierrez-Sigut, Eva; Costello, Brendan; Baus, Cristina; Carreiras, Manuel

    2016-03-01

    The LSE-Sign database is a free online tool for selecting Spanish Sign Language stimulus materials to be used in experiments. It contains 2,400 individual signs taken from a recent standardized LSE dictionary, and a further 2,700 related nonsigns. Each entry is coded for a wide range of grammatical, phonological, and articulatory information, including handshape, location, movement, and non-manual elements. The database is accessible via a graphically based search facility which is highly flexible both in terms of the search options available and the way the results are displayed. LSE-Sign is available at the following website: http://www.bcbl.eu/databases/lse/.

  10. Chvostek's sign in paediatric practice.

    Science.gov (United States)

    Hasan, Zeeshaan U; Absamara, Rania; Ahmed, Mas

    2014-01-01

    Chvostek's Sign was first described in 1876, as a clinical clue associated with patients who suffered from latent tetany, and is induced by percussion of the angle of the jaw. However, over the years many clinicians have called into question the strength of the association with latent tetany, particularly in paediatric practice. This review examines the variation in techniques used to elicit the sign in studies conducted on this phenomenon in children as well as how differences in the classification of a positive Chvostek's sign have lead to varied reports on the strength of the association. Furthermore, an appraisal of the literature regarding the proposed mechanism of Chvostek's sign is reported alongside analysing other diseases which have been associated with Chvostek's sign to uncover any unifying mechanism for the presence of this clinical sign in children.

  11. RegPrecise 3.0--a resource for genome-scale exploration of transcriptional regulation in bacteria.

    Science.gov (United States)

    Novichkov, Pavel S; Kazakov, Alexey E; Ravcheev, Dmitry A; Leyn, Semen A; Kovaleva, Galina Y; Sutormin, Roman A; Kazanov, Marat D; Riehl, William; Arkin, Adam P; Dubchak, Inna; Rodionov, Dmitry A

    2013-11-01

    Genome-scale prediction of gene regulation and reconstruction of transcriptional regulatory networks in prokaryotes is one of the critical tasks of modern genomics. Bacteria from different taxonomic groups, whose lifestyles and natural environments are substantially different, possess highly diverged transcriptional regulatory networks. The comparative genomics approaches are useful for in silico reconstruction of bacterial regulons and networks operated by both transcription factors (TFs) and RNA regulatory elements (riboswitches). RegPrecise (http://regprecise.lbl.gov) is a web resource for collection, visualization and analysis of transcriptional regulons reconstructed by comparative genomics. We significantly expanded a reference collection of manually curated regulons we introduced earlier. RegPrecise 3.0 provides access to inferred regulatory interactions organized by phylogenetic, structural and functional properties. Taxonomy-specific collections include 781 TF regulogs inferred in more than 160 genomes representing 14 taxonomic groups of Bacteria. TF-specific collections include regulogs for a selected subset of 40 TFs reconstructed across more than 30 taxonomic lineages. Novel collections of regulons operated by RNA regulatory elements (riboswitches) include near 400 regulogs inferred in 24 bacterial lineages. RegPrecise 3.0 provides four classifications of the reference regulons implemented as controlled vocabularies: 55 TF protein families; 43 RNA motif families; ~150 biological processes or metabolic pathways; and ~200 effectors or environmental signals. Genome-wide visualization of regulatory networks and metabolic pathways covered by the reference regulons are available for all studied genomes. A separate section of RegPrecise 3.0 contains draft regulatory networks in 640 genomes obtained by an conservative propagation of the reference regulons to closely related genomes. RegPrecise 3.0 gives access to the transcriptional regulons reconstructed in

  12. Space is special in Sign.

    Science.gov (United States)

    Campbell, Ruth; Woll, Bencie

    2003-01-01

    Following groundbreaking work by linguists and cognitive scientists over the past thirty years, it is now generally accepted that sign languages of the deaf, such as ASL (American Sign Language) or BSL (British Sign Language), are structured and processed in a similar manner to spoken languages. The one striking difference is that they operate in a wholly non-auditory, visuospatial medium. How does the medium impact on language processing itself?

  13. Impact of dust size parameterizations on aerosol burden and radiative forcing in RegCM4

    Science.gov (United States)

    Tsikerdekis, Athanasios; Zanis, Prodromos; Steiner, Allison L.; Solmon, Fabien; Amiridis, Vassilis; Marinou, Eleni; Katragkou, Eleni; Karacostas, Theodoros; Foret, Gilles

    2017-01-01

    We investigate the sensitivity of aerosol representation in the regional climate model RegCM4 for two dust parameterizations for the period 2007-2014 over the Sahara and the Mediterranean. We apply two discretization methods of the dust size distribution keeping the total mass constant: (1) the default RegCM4 4-bin approach, where the size range of each bin is calculated using an equal, logarithmic separation of the total size range of dust, using the diameter of dust particles, and (2) a newly implemented 12-bin approach with each bin defined according to an isogradient method where the size ranges are dependent on the dry deposition velocity of dust particles. Increasing the number of transported dust size bins theoretically improves the representation of the physical properties of dust particles within the same size bin. Thus, more size bins improve the simulation of atmospheric processes. The radiative effects of dust over the area are discussed and evaluated with the CALIPSO dust optical depth (DOD). This study is among the first studies evaluating the vertical profile of simulated dust with a pure dust product. Reanalysis winds from ERA-Interim and the total precipitation flux from the Climate Research Unit (CRU) observational gridded database are used to evaluate and explain the discrepancies between model and observations. The new dust binning approach increases the dust column burden by 4 and 3 % for fine and coarse particles, respectively, which increases DOD by 10 % over the desert and the Mediterranean. Consequently, negative shortwave radiative forcing (RF) is enhanced by more than 10 % at the top of the atmosphere and by 1 to 5 % on the surface. Positive longwave RF locally increases by more than 0.1 W m-2 in a large portion of the Sahara, the northern part of the Arabian Peninsula and the Middle East. The four-bin isolog method is to some extent numerically efficient, nevertheless our work highlights that the simplified representation of the four

  14. Validation of newly designed regional earth system model (RegESM) for Mediterranean Basin

    Science.gov (United States)

    Turuncoglu, Ufuk Utku; Sannino, Gianmaria

    2017-05-01

    We present a validation analysis of a regional earth system model system (RegESM) for the Mediterranean Basin. The used configuration of the modeling system includes two active components: a regional climate model (RegCM4) and an ocean modeling system (ROMS). To assess the performance of the coupled modeling system in representing the climate of the basin, the results of the coupled simulation (C50E) are compared to the results obtained by a standalone atmospheric simulation (R50E) as well as several observation datasets. Although there is persistent cold bias in fall and winter, which is also seen in previous studies, the model reproduces the inter-annual variability and the seasonal cycles of sea surface temperature (SST) in a general good agreement with the available observations. The analysis of the near-surface wind distribution and the main circulation of the sea indicates that the coupled model can reproduce the main characteristics of the Mediterranean Sea surface and intermediate layer circulation as well as the seasonal variability of wind speed and direction when it is compared with the available observational datasets. The results also reveal that the simulated near-surface wind speed and direction have poor performance in the Gulf of Lion and surrounding regions that also affects the large positive SST bias in the region due to the insufficient horizontal resolution of the atmospheric component of the coupled modeling system. The simulated seasonal climatologies of the surface heat flux components are also consistent with the CORE.2 and NOCS datasets along with the overestimation in net long-wave radiation and latent heat flux (or evaporation, E), although a large observational uncertainty is found in these variables. Also, the coupled model tends to improve the latent heat flux by providing a better representation of the air-sea interaction as well as total heat flux budget over the sea. Both models are also able to reproduce the temporal evolution of

  15. Validation of newly designed regional earth system model (RegESM) for Mediterranean Basin

    Science.gov (United States)

    Turuncoglu, Ufuk Utku; Sannino, Gianmaria

    2016-06-01

    We present a validation analysis of a regional earth system model system (RegESM) for the Mediterranean Basin. The used configuration of the modeling system includes two active components: a regional climate model (RegCM4) and an ocean modeling system (ROMS). To assess the performance of the coupled modeling system in representing the climate of the basin, the results of the coupled simulation (C50E) are compared to the results obtained by a standalone atmospheric simulation (R50E) as well as several observation datasets. Although there is persistent cold bias in fall and winter, which is also seen in previous studies, the model reproduces the inter-annual variability and the seasonal cycles of sea surface temperature (SST) in a general good agreement with the available observations. The analysis of the near-surface wind distribution and the main circulation of the sea indicates that the coupled model can reproduce the main characteristics of the Mediterranean Sea surface and intermediate layer circulation as well as the seasonal variability of wind speed and direction when it is compared with the available observational datasets. The results also reveal that the simulated near-surface wind speed and direction have poor performance in the Gulf of Lion and surrounding regions that also affects the large positive SST bias in the region due to the insufficient horizontal resolution of the atmospheric component of the coupled modeling system. The simulated seasonal climatologies of the surface heat flux components are also consistent with the CORE.2 and NOCS datasets along with the overestimation in net long-wave radiation and latent heat flux (or evaporation, E), although a large observational uncertainty is found in these variables. Also, the coupled model tends to improve the latent heat flux by providing a better representation of the air-sea interaction as well as total heat flux budget over the sea. Both models are also able to reproduce the temporal evolution of

  16. Sign Languages of the World

    DEFF Research Database (Denmark)

    This handbook provides information on some 38 sign languages, including basic facts about each of the languages, structural aspects, history and culture of the Deaf communities, and history of research. The papers are all original, and each has been specifically written for the volume by an expert...... or team of experts in the particular sign language, at the invitation of the editors. Thirty-eight different deaf sign languages and alternate sign languages from every continent are represented, and over seventy international deaf and hearing scholars have contributed to the volume....

  17. Traffic-Sign Recognition Systems

    CERN Document Server

    Escalera, Sergio

    2011-01-01

    This work presents a full generic approach to the detection and recognition of traffic signs. The approach is based on the latest computer vision methods for object detection, and on powerful methods for multiclass classification. The challenge was to robustly detect a set of different sign classes in real time, and to classify each detected sign into a large, extensible set of classes. To address this challenge, several state-of-the-art methods were developed that can be used for different recognition problems. Following an introduction to the problems of traffic sign detection and categoriza

  18. Planning Sign Languages: Promoting Hearing Hegemony? Conceptualizing Sign Language Standardization

    Science.gov (United States)

    Eichmann, Hanna

    2009-01-01

    In light of the absence of a codified standard variety in British Sign Language and German Sign Language ("Deutsche Gebardensprache") there have been repeated calls for the standardization of both languages primarily from outside the Deaf community. The paper is based on a recent grounded theory study which explored perspectives on sign…

  19. Signs of Change: Contemporary Attitudes to Australian Sign Language

    Science.gov (United States)

    Slegers, Claudia

    2010-01-01

    This study explores contemporary attitudes to Australian Sign Language (Auslan). Since at least the 1960s, sign languages have been accepted by linguists as natural languages with all of the key ingredients common to spoken languages. However, these visual-spatial languages have historically been subject to ignorance and myth in Australia and…

  20. Evaluation and comparison of SuperLig{reg_sign} 644, resorcinol-formaldehyde and CS-100 ion exchange materials for the removal of cesium from simulated alkaline supernate

    Energy Technology Data Exchange (ETDEWEB)

    Brown, G.N.; Bray, L.A.; Eloviche, R.J. [Pacific Northwest Lab., Richland, WA (United States); Bruening, R.L.; Decker, R.M. [IBC Advanced Technologies, Inc., Provo, UT (United States); Kafka, T.M.; White, L.R. [3M Co., St. Paul, MN (United States)

    1995-03-01

    PNL evaluated three polymeric materials for Cs removal efficiency from a simulated Hanford Neutralized Current Acid Waste (NCAW) supernatant liquid using 200 mL ion exchange columns. Cs loadings (mmole Cs/g resin) were 0.20, 0.18, and 0.039 for Super Lig 644, R-F, and CS-100 (0.045, 0.070, 0.011 mmole Cs/mL resin). Elution of each resin material with 0.5 M HNO{sub 3} required 3.5, 7.0, and 3.2 cv to reach 0.1 C/C{sub 0} for the respective materials, resulting in volume compressions of 27, 20, and 6.9. Peak Cs concentrations during elution was 185, 38.5, and 27.8 C/C{sub 0}. SuperLig 644 had the highest Cs loading per gram in NCAW and the greatest volume compression on aci elution. Because of high density and poor elution, R-F had the highest Cs loading per unit volume and lower volume compression. CS-100, the baseline material for Cs removal at Hanford, was inferior to both SuperLig 644 and R-F in terms of Cs loading and selectivity over sodium.

  1. Closing the knowledge gap on cardiovascular disease in type 2 diabetes: the EMPA-REG OUTCOME trial and beyond

    Directory of Open Access Journals (Sweden)

    Elif A Oral

    2016-09-01

    Full Text Available Type 2 diabetes mellitus (T2DM is associated with marked cardiovascular (CV morbidity and mortality, including heartfailure (HF. Until recently, an oral glucose-lowering agent that improved hyperglycemia as well as provided CV benefits in patients with T2DM and cardiovascular disease (CVD was lacking. The newest class of glucose-lowering agents, sodium glucose cotransporter 2 (SGLT2 inhibitors, includes canagliflozin, dapagliflozin, and empagliflozin. Prior to the release of the LEADER trial results, the recent EMPA-REG OUTCOME study was the only dedicated CV trial to demonstrate a reduction in major adverse cardiac events, CV mortality, and all-cause mortality and a reduction in hospitalization for HF with empagliflozin, given on top of standard-of-care therapy in patients with T2DM and CVD. This paper summarizes the results from EMPA-REG OUTCOME and discusses their significance and clinical implications.

  2. The Super Separator Spectrometer S3 and the associated detection systems: SIRIUS & LEB-REGLIS3

    Science.gov (United States)

    Déchery, F.; Savajols, H.; Authier, M.; Drouart, A.; Nolen, J.; Ackermann, D.; Amthor, A. M.; Bastin, B.; Berryhill, A.; Boutin, D.; Caceres, L.; Coffey, M.; Delferrière, O.; Dorvaux, O.; Gall, B.; Hauschild, K.; Hue, A.; Jacquot, B.; Karkour, N.; Laune, B.; Le Blanc, F.; Lecesne, N.; Lopez-Martens, A.; Lutton, F.; Manikonda, S.; Meinke, R.; Olivier, G.; Payet, J.; Piot, J.; Pochon, O.; Prince, V.; Souli, M.; Stelzer, G.; Stodel, C.; Stodel, M.-H.; Sulignano, B.; Traykov, E.; Uriot, D.

    2016-06-01

    The Super Separator Spectrometer (S3) facility is developed in the framework of the SPIRAL2 project [1]. S3 has been designed to extend the capability of the facility to perform experiments with extremely low cross sections, taking advantage of the very high intensity stable beams of the superconducting linear accelerator of SPIRAL2. It will mainly use fusion-evaporation reactions to reach extreme regions of the nuclear chart: new opportunities will be opened for super-heavy element studies and spectroscopy at and beyond the driplines. In addition to our previous article (Déchery et al. [2]) introducing the optical layout of the spectrometer and the expected performances, this article will present the current status of the main elements of the facility: the target station, the superconducting multipole, and the magnetic and electric dipoles, with a special emphasis on the status of the detection system SIRIUS and on the low-energy branch which includes the REGLIS3 system. S3 will also be a source of low energy radioactive isotopes for delivery to the DESIR facility.

  3. Exposing the impact of opp(reg)ressive policies on teacher development and on student learning

    Science.gov (United States)

    Rodriguez, Alberto J.

    2010-12-01

    This case study draws attention to Pedro's story, a Grade 6 Latino teacher who, along with other grade 4-6 teachers, participated in a three-year professional development research project. By using data analyzed from multiple ethnographic interviews with teachers and students, and by drawing from the quantitative analyzes of concept map unit tests, we illustrate how Pedro's significant professional growth and his students' learning were truncated by top-down school district policies. These policies were implemented because of the punitive nature of the No Child Left Behind Act. Simply put, this case study exposes the impact of opp(reg)ressive policies on learning, that is, policies simultaneously oppressive and regressive. The critical perspective of the project, and its emphasis on assisting teachers to make their pedagogy and curriculum more culturally and socially relevant, was informed by sociotransformative constructivism (sTc). This is a theoretical framework that affords equal importance to cross-cultural education (learning about and acting on socially/culturally relevant issues) and social constructivism (learning to critically produce and consume knowledge). We hope that this case study will provide additional insights into the slow progress we continue to make in science teacher professional development and in closing the achievement gap.

  4. Measurement and modeling of residual stress in a welded Haynes[reg] 25 cylinder

    Energy Technology Data Exchange (ETDEWEB)

    Larsson, C. [Div. of Eng. Mat., Department of Mech. Eng., Linkoeping University, 58183 Linkoeping (Sweden)]. E-mail: clarsson@cfl.rr.com; Holden, T.M. [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Bourke, M.A.M. [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Stout, M. [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Teague, J. [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Lindgren, L.-E. [Div. Comp. Aided Design, Lulea University of Technology and Dalarna University, 97187 Lulea (Sweden)

    2005-06-15

    An experimental and simulation study of residual stresses was made in the vicinity of a gas tungsten arc weld, used to join a hemispherical end cap to a cylinder. The capped cylinder is used in a satellite application and was fabricated from a Co-based Haynes[reg] 25 alloy. The cylinder was 34.7 mm in outer diameter and 3.3 mm in thickness. The experimental measurements were made by neutron diffraction and the simulation used the implicit Marc finite element code. The experimental resolution was limited to approximately 3 mm parallel to the axis of the cylinder (the weld was 6 mm in the same direction) and comparison over the same volume of the finite element prediction showed general agreement. Subject to the limited spatial resolution, the largest experimentally measured tensile residual stress was 180 MPa, located at the middle of the weld. However, the predictions suggest that there are regions in the weld where average tensile residual stresses as much as 400 MPa exist. One qualitative disparity between the model and the experiments was that the measurement included a larger degree of asymmetry on either side of the weld than predicted by the model.

  5. The Reg family member INGAP is a marker of endocrine patterning in the embryonic pancreas.

    Science.gov (United States)

    Hamblet, Natasha S; Shi, Wenjing; Vinik, Aaron I; Taylor-Fishwick, David A

    2008-01-01

    Adult islet neogenesis is believed to recapitulate elements of pancreatic endocrine development. Identifying factors that regulate islet neogenesis-associated protein (INGAP) gene activity could provide links to pancreas development. Predicted transcriptional regulators of INGAP were screened in an INGAP-promoter-reporter assay. Based upon their temporal expression, the occurrence of INGAP-positive cells during pancreas embryonic development were studied. Pancreatic transcription factors, PDX-1, Ngn3, NeuroD, and Isl-1, activated the INGAP promoter, but PAX4, PAX6, and Nkx2.2 did not. The INGAP-positive cells were present in the developing pancreatic bud of the mouse embryo. Emerging clusters of unorganized endocrine cells were INGAP positive. These cells coexpressed insulin or somatostatin, but glucagon-expressing cells remained distinct. The INGAP-positive cells were also detected in the maturing neonatal endocrine cells organized into islets. In direct contrast to the embryo, glucagon localized with most INGAP-positive cells in the postnatal endocrine cells. The INGAP-positive cells juxtaposed pancreatic duct cells. A subset of 5-bromo-2'-deoxyuridine-positive/INGAP-positive cells was detected in the neonatal pancreas. These data implicate INGAP and/or Reg family proteins in endocrine cell patterning during embryonic development and suggest that INGAP immunoreactivity is a key marker associated with early endocrine cells.

  6. Bio-normalyzer[reg]: An anti-cancer drug for neuroblastoma?

    Energy Technology Data Exchange (ETDEWEB)

    Gouget, B. E-mail: gouget@drecam.cea.fr; Sergeant, C.; Llabador, Y.; Simonoff, M

    2001-07-01

    Iron is an essential micronutrient required for cell division and growth. Incorporation of iron into cells is achieved by endocytosis of transferrin. Then, iron may be stored in ferritin and hemosiderin. Increased intracellular iron concentrations may promote malignant cell growth. Patients with advanced-stage neuroblastoma (NB) show abnormally high levels of serum ferritin, very likely synthesized and secreted by the tumor in vivo and consistent with a frequent accumulation of iron in ferritin in NB tumor tissues. In a previous study, we showed that there is no iron accumulation in cultured neuroblasts, and intracellular iron concentrations proved to be especially low. Bio-Normalizer[reg] (BioN) is a nutritional supplement sold to be an anti-oxidant and metal-chelator. In the present study, we tested cell viability and measured iron concentrations in neuroblasts treated or not with BioN. We found that BioN, probably thanks to papain, presents an anti-proliferative effect on NB cultured cells. Besides, preliminary results tend to prove that this natural anti-oxidant and iron-chelator could present interesting effects on trace metal concentrations in neuroblasts. Such a compound may be useful in treatment of this pathology.

  7. Direct Radiative Forcing and Climatic Effects of Aerosols over East Asia by RegCM3

    Institute of Scientific and Technical Information of China (English)

    JU Li-Xia; HAN Zhi-Wei

    2011-01-01

    The authors used a high-resolution regional climate model (RegCM3) coupled with a chemistry/ aerosol module to simulate East Asian climate in 2006 and to test the climatic impacts of aerosols on regional- scale climate. The direct radiative forcing and climatic effects of aerosols (dust, sulfate, black carbon, and organic carbon) were discussed. The results indicated that aerosols generally produced negative radiative forcing at the top-of-the-atmosphere (TOA) over most areas of East Asia. The radiative forcing induced by aerosols exhibited significant seasonal and regional variations, with the strongest forcing occurring in summer. The aerosol feed- backs on surface air temperature and precipitation were clear. Surface cooling dominated features over the East Asian continental areas, which varied in the approximate range of-0.5 to -2℃ with the maximum up to -3℃ in summer over the deserts of West China. The aerosols induced complicated variations of precipitation. Except in summer, the rainfall generally varied in the range of-1 to 1 mm d^-1 over most areas of China.

  8. The Regulatory Effect of Natural Killer Cells: Do "NK-reg Cells" Exist?

    Institute of Scientific and Technical Information of China (English)

    Cai Zhang; Jian Zhang; Zhigang Tian

    2006-01-01

    The most important progress in immunology in the last decade is the description of regulatory lymphocytes, among which Treg cells and regulatory NKT cells are much attractive to not only immunologists but also almost all biomedical researchers. Meanwhile, it is noted that NK cells are not only "Killers" but also regulate innate and adaptive immunity, especially in early stage, by secreting cytokines and cell-cell contact. In this review, we are going to briefly summarize the progresses in regulatory lymphocytes including T cells (Treg, Tr1, Th3), NKT cells and NK cells, and then extensively introduce the positive regulatory function of NK cells in both normal immune response and in disease condition (tumor, infection and autoimmunity), and finally, to focus on the most latest progression in the negative regulatory effects of NK cells on normal and pathogenic immune response. In conclusion, we speculate that a "regulatory NK (NK-reg)" cell subset exist and need to explore. Cellular & Molecular Immunology. 2006;3(4):241-254.

  9. Chemical mechanical planarization of Ge2Sb2Te5 using IC1010 and Politex reg pads in acidic slurry

    Science.gov (United States)

    He, Ao-Dong; Liu, Bo; Song, Zhi-Tang; Wang, Liang-Yong; Liu, Wei-Li; Feng, Gao-Ming; Feng, Song-Lin

    2014-08-01

    In the paper, chemical mechanical planarization (CMP) of Ge2Sb2Te5 (GST) is investigated using IC1010 and Politex reg pads in acidic slurry. For the CMP with blank wafer, it is found that the removal rate (RR) of GST increases with the increase of pressure for both pads, but the RR of GST polished using IC1010 is far more than that of Politex reg. To check the surface defects, GST film is observed with an optical microscope (OM) and scanning electron microscope (SEM). For the CMP with Politex reg, many spots are observed on the surface of the blank wafer with OM, but no obvious spots are observed with SEM. With regard to the patterned wafer, a few stains are observed on the GST cell, but many residues are found on other area with OM. However, from SEM results, a few residues are observed on the GST cell, more dielectric loss is revealed about the trench structure. For the CMP with IC1010, the surface of the polished blank wafer suffers serious scratches found with both OM and SEM, which may result from a low hardness of GST, compared with those of IC1010 and abrasives. With regard to the patterned wafer, it can achieve a clean surface and almost no scratches are observed with OM, which may result from the high-hardness SiO2 film on the surface, not from the soft GST film across the whole wafer. From the SEM results, a clean interface and no residues are observed on the GST surface, and less dielectric loss is revealed. Compared with Politex reg, the patterned wafer can achieve a good performance after CMP using IC1010.

  10. Learning to Detect Traffic Signs

    DEFF Research Database (Denmark)

    Møgelmose, Andreas; Trivedi, Mohan M.; Moeslund, Thomas B.

    2012-01-01

    This study compares the performance of sign detection based on synthetic training data to the performance of detection based on real-world training images. Viola-Jones detectors are created for 4 different traffic signs with both synthetic and real data, and varying numbers of training samples...

  11. Climate Projections for South America: RegCM3 Driven by HadCM3 and ECHAM5

    Directory of Open Access Journals (Sweden)

    Michelle Simões Reboita

    2014-01-01

    Full Text Available This study shows climate projections of air temperature and precipitation over South America (SA from the Regional Climate Model version 3 (RegCM3 nested in ECHAM5 and HadCM3 global models. The projections consider the A1B scenario from Intergovernmental Panel on Climate Change (IPCC and three time-slices: present (1960–1990, near- (2010–2040, and far-future (2070–2100 climates. In the future, RegCM3 projections indicate general warming throughout all SA and seasons, which is more pronounced in the far-future period. In this late period the RegCM3 projections indicate that the negative trend of precipitation over northern SA is also higher. In addition, a precipitation increase over southeastern SA is projected, mainly during summer and spring. The lifecycle of the South American monsoon (SAM was also investigated in the present and future climates. In the near-future, the projections show a slight delay (one pentad of the beginning of the rainy season, resulting in a small reduction of the SAM length. In the far-future, there is no agreement between projections related to the SAM features.

  12. Implementation and evaluation of online gas-phase chemistry within a regional climate model (RegCM-CHEM4

    Directory of Open Access Journals (Sweden)

    A. K. Shalaby

    2012-01-01

    Full Text Available The RegCM-CHEM4 is a new online climate-chemistry model based on the International Centre for Theoretical Physics (ICTP regional climate model (RegCM4. Tropospheric gas-phase chemistry is integrated into the climate model using the condensed version of the Carbon Bond Mechanism (CBM-Z; Zaveri and Peters, 1999 with a fast solver based on radical balances. We evaluate the model over Continental Europe for two different time scales: (1 an event-based analysis of the ozone episode associated with the heat wave of August 2003 and (2 a climatological analysis of a six-year simulation (2000–2005. For the episode analysis, model simulations show good agreement with European Monitoring and Evaluation Program (EMEP observations of hourly ozone over different regions in Europe and capture ozone concentrations during and after the August 2003 heat wave event. For long-term climate simulations, the model captures the seasonal cycle of ozone concentrations with some over prediction of ozone concentrations in non-heat wave summers. Overall, the ozone and ozone precursor evaluation shows the feasibility of using RegCM-CHEM4 for decadal-length simulations of chemistry-climate interactions.

  13. Implementation of a Surface Runoff Model with Horton and Dunne Mechanisms into the Regional Climate Model RegCM_NCC

    Institute of Scientific and Technical Information of China (English)

    SHI Xueli; XIE Zhenghui; LIU Yiming; YANG Hongwei

    2007-01-01

    A surface runoff parameterization scheme that dynamically represents both Horton and Dunne runoff generation mechanisms within a model grid cell together with a consideration of the subgrid-scale soil heterogeneity, is implemented into the National Climate Center regional climate model (RegCM_NCC). The effects of the modified surface runoff scheme on RegCM_NCC performance are tested with an abnormal heavy rainfall process which occurred in summer 1998. Simulated results show that the model with the original surface runoff scheme (noted as CTL) basically captures the spatial pattern of precipitation, circulation and land surface variables, but generally overestimates rainfall compared to observations. The model with the new surface runoff scheme (noted as NRM) reasonably reproduces the distribution pattern of various variables and effectively diminishes the excessive precipitation in the CTL. The processes involved in the improvement of NRM-simulated rainfall may be as follows: with the new surface runoff scheme, simulated surface runoff is larger, soil moisture and evaporation (latent heat flux) are decreased, the available water into the atmosphere is decreased; correspondingly, the atmosphere is drier and rainfall is decreased through various processes. Therefore, the implementation of the new runoff scheme into the RegCM_NCC has a significant effect on results at not only the land surface, but also the overlying atmosphere.

  14. Use of RegCM gridded dataset for thunderstorm favorable conditions analysis over Poland—climatological approach

    Science.gov (United States)

    Walawender, Ewelina; Kielar, Rafał; Ustrnul, Zbigniew

    2017-01-01

    The paper analyzes equivalent data for a low density meteorological station network (spatially discontinuous data) and poor temporal homogeneity of thunderstorm observational data. Due to that, a Regional Climate Model (RegCM) dataset was tested. The Most Unstable Convective Available Potential Energy index value (MUCAPE) above the 200 J kg-1 threshold was selected as a predictor describing favorable conditions for the occurrence of thunderstorms. The quality of the dataset was examined through a comparison between model results and soundings from several aerological stations in Central Europe. Good, statistically significant (0.05 significance level) results were obtained through correlation analysis; the value of Pearson's correlation coefficient was above 0.8 in every single case. Then, using methods associated with gridded climatology, data series for 44 weather stations were derived and an analysis of correlation between RegCM modeled data and in situ thunderstorm observations was conducted with coefficients in the range of 0.75-0.90. The possibility of employing the dataset in thunderstorm climatology analysis was checked via a few examples by mapping monthly, seasonal, and annual means. Moreover, long-term variability and trend analysis along with modeled MUCAPE data were tested. As a result, the RegCM modeled MUCAPE gridded dataset was proposed as an easily available, suitable, and valuable predictor for thunderstorm climatology analysis and mapping. Finally, some limitations are discussed and recommendations for further improvements are given.

  15. Implementation and evaluation of online gas-phase chemistry within a regional climate model (RegCM-CHEM4)

    Energy Technology Data Exchange (ETDEWEB)

    Shalaby, A. K.; Zakey, A. S.; Tawfik, A. B.; Solmon, F.; Giorgi, Filippo; Stordal, F.; Sillman, S.; Zaveri, Rahul A.; Steiner, A. L.

    2012-05-22

    The RegCM-CHEM4 is a new online climate-chemistry model based on the International Centre for Theoretical Physics (ICTP) regional climate model (RegCM4). Tropospheric gas-phase chemistry is integrated into the climate model using the condensed version of the Carbon Bond Mechanism (CBM-Z; Zaveri and Peters, 1999) with a fast solver based on radical balances. We evaluate the model over Continental Europe for two different time scales: (1) an event-based analysis of the ozone episode associated with the heat wave of August 2003 and (2) a climatological analysis of a sixyear simulation (2000-2005). For the episode analysis, model simulations show good agreement with European Monitoring and Evaluation Program (EMEP) observations of hourly ozone over different regions in Europe and capture ozone concentrations during and after the August 2003 heat wave event. For long-term climate simulations, the model captures the seasonal cycle of ozone concentrations with some over prediction of ozone concentrations in non-heat wave summers. Overall, the ozone and ozone precursor evaluation shows the feasibility of using RegCM-CHEM4 for decadal-length simulations of chemistry-climate interactions.

  16. Aportes al sistema general de seguridad social en salud de personas pertenecientes a regímenes excepcionales por ingresos adicionales

    OpenAIRE

    Bedoya Ospina, Diana Carolina; White Londoño, Diana

    2012-01-01

    En el presente proyecto de grado se hará una investigación de la normatividad que regula los diferentes regímenes exceptuados que existen en el Sistema Integral de Seguridad Social en Salud en Colombia. Específicamente, se estudiara que sucede en el evento en que una persona afiliada como cotizante a dichos regímenes perciba ingresos adicionales sobre los cuales este obligado a cotizar al Sistema General de Seguridad Social en Salud.

  17. Control of CydB and GltA1 expression by the SenX3 RegX3 two component regulatory system of Mycobacterium tuberculosis.

    Directory of Open Access Journals (Sweden)

    Gretta Roberts

    Full Text Available Two component regulatory systems are used widely by bacteria to coordinate changes in global gene expression profiles in response to environmental signals. The SenX3-RegX3 two component system of Mycobacterium tuberculosis has previously been shown to play a role in virulence and phosphate-responsive control of gene expression. We demonstrate that expression of SenX3-RegX3 is controlled in response to growth conditions, although the absolute changes are small. Global gene expression profiling of a RegX3 deletion strain and wild-type strain in different culture conditions (static, microaerobic, anaerobic, as well as in an over-expressing strain identified a number of genes with changed expression patterns. Among those were genes previously identified as differentially regulated in aerobic culture, including ald (encoding alanine dehydrogenase cyd,encoding a subunit of the cytochrome D ubiquinol oxidase, and gltA1, encoding a citrate synthase. Promoter activity in the upstream regions of both cydB and gltA1 was altered in the RegX3 deletion strain. DNA-binding assays confirmed that RegX3 binds to the promoter regions of ald, cydB and gltA1 in a phosphorylation-dependent manner. Taken together these data suggest a direct role for the SenX-RegX3 system in modulating expression of aerobic respiration, in addition to its role during phosphate limitation.

  18. FROM SAUSSURE TO CHARAUDEAU: LANGAUGE SIGN AND DISCOURSE SIGN

    Directory of Open Access Journals (Sweden)

    André Crim Valente

    2015-07-01

    Full Text Available The work of Ferdinand de Saussure was massively revisited, in 2013, the year of the centenary of the death of the Genevian Master. In fact, his linguistic production has always been the object of several studies since the publication of Course in General Linguistics, in 1916. This article brings to light the considerations of renowned linguists on the Saussurean work and its links with Discourse Analysis (DA, considering the notions of language sign and discourse sign. Among the various branches of DA, it is made an option herein for the Semiolinguistic conception of discourse, based on the work of Patrick Charaudeau, with emphasis on the concept of contract of communication. With the support of such theoretical support, media texts, verbal and non-verbal, will be analyzed in order to highlight the importance of linguistic signs – language and discourse signs – in the construction of meaning in such text genre.

  19. Sign Inference for Dynamic Signed Networks via Dictionary Learning

    Directory of Open Access Journals (Sweden)

    Yi Cen

    2013-01-01

    Full Text Available Mobile online social network (mOSN is a burgeoning research area. However, most existing works referring to mOSNs deal with static network structures and simply encode whether relationships among entities exist or not. In contrast, relationships in signed mOSNs can be positive or negative and may be changed with time and locations. Applying certain global characteristics of social balance, in this paper, we aim to infer the unknown relationships in dynamic signed mOSNs and formulate this sign inference problem as a low-rank matrix estimation problem. Specifically, motivated by the Singular Value Thresholding (SVT algorithm, a compact dictionary is selected from the observed dataset. Based on this compact dictionary, the relationships in the dynamic signed mOSNs are estimated via solving the formulated problem. Furthermore, the estimation accuracy is improved by employing a dictionary self-updating mechanism.

  20. Sign order in Slovenian Sign Language locative constructions

    Directory of Open Access Journals (Sweden)

    Matic Pavlič

    2016-12-01

    Full Text Available In both sign and spoken languages, locative relations tend to be encoded within constructions that display the non-basic word/sign order. In addition, in such an environment, sign languages habitually use a distinct predicate type – a classifier predicate – which may independently affect the order of constituents in the sentence. In this paper, I present Slovenian Sign Language (SZJ locative constructions, in which (i the argument that enables spatial anchoring (“ground” precedes both the argument that requires spatial anchoring (“figure” and the predicate. At the same time, (ii the relative order of the figure with respect to the predicate depends on the type of predicate employed: a non-classifier predicate precedes the figure, while a classifier predicate only comes after the figure.

  1. [Hemiplegia with two Babinski's sign].

    Science.gov (United States)

    Leon-Sarmiento, Fidias E; Montoya, María C; Camacho, John E; Bayona-Prieto, Jaime; Bayona, Edgardo

    2007-01-01

    Neurological signs and symptoms are very important to establish a correct neurological diagnosis. We present here a Colombian female patient, 60 years-old, who had ischaemic stroke in the left cerebral media artery. It produced right hemiplegia, motor aphasia, "central" facial palsy and atrophy of right platysma muscle. This latter finding, described originally by Joseph Babinski as "The Babinski Sign" was observed only two years and seven months after the ictus even when she had, previously, been evaluated by several neurologists. The underdiagnosis of clinical signs like the one described here may lead to erroneous diagnosis that will, ultimately, affect neurorehabilitation measures.

  2. Hush sign: a new clinical sign in temporal lobe epilepsy.

    Science.gov (United States)

    Kutlu, Gulnihal; Bilir, Erhan; Erdem, Atilla; Gomceli, Yasemin B; Kurt, G Semiha; Serdaroglu, Ayse

    2005-05-01

    Neurologists have been analyzing the clinical behaviors that occur during seizures for many years. Several ictal behaviors have been defined in temporal lobe epilepsy (TLE). Ictal behaviors are especially important in the evaluation of epilepsy surgery candidates. We propose a new lateralizing sign in TLE originating from the nondominant hemisphere-the "hush" sign. Our patients were 30- and 21-year old women (Cases 1 and 2, respectively). Their epileptogenic foci were localized to the right mesial temporal region after noninvasive presurgical investigations. Case 1 had no cranial MRI abnormality, whereas cranial MRI revealed right hippocampal atrophy in Case 2. These women repeatedly moved their right index fingers to their mouth while puckering their lips during complex partial seizures. We have named this ictal behavior the "hush" sign. Anterior temporal lobectomy with amygdalohippocampectomy was performed in both patients, and pathological examinations revealed hippocampal sclerosis. The "hush" sign no longer occurred after seizures were controlled. They were seizure free as of 30 and 31 months of follow-up, respectively. We believe that the "hush" sign may be supportive of a diagnosis of TLE originating from the nondominant hemisphere. This sign may occur as a result of ictal activation of a specific brain region in this hemisphere.

  3. Effects of climate changes on dust aerosol over East Asia from RegCM3

    Directory of Open Access Journals (Sweden)

    Dong-Feng Zhang

    2016-09-01

    Full Text Available In order to understand impacts of global warming on dust aerosol over East Asia, a regional climate model (RegCM3 coupled with a dust model is employed to simulate the present (1991–2000, following the observed concentration of the greenhouse gases and future (2091–2100, following the A1B scenario dust aerosol. Three experiments are performed over East Asia at a horizontal resolution of 50 km, driven by the outputs from a global model of the Model for Interdisciplinary Research on Climate (MIROC3.2_hires, two without (Exp.1 for the present and Exp.2 for the future and one with (Exp.3 for the future the radiative effects of dust aerosols. Effects of climate changes on dust aerosols and the feedback of radiative effects in the future are investigated by comparing differences of Exp.2 and Exp.1, Exp.3 and Exp.2, respectively. Results show that global warming will lead to the increases of dust emissions and column burden by 2% and 14% over East Asia, characterized by the increase in December–January–February–March (DJFM and the decrease in April–May (AM. Similar variations are also seen in the projected frequencies of high dust emission events, showing an advanced active season of dust in the future. The net top-of-atmosphere (TOA radiative forcing is positive over the desert source regions and negative over downwind regions, while the surface radiative forcing is negative over the domain, which will lead to a reduction of dust emissions and column burden.

  4. Variability of East African rainfall based on multi-year RegCM3 simulations

    Science.gov (United States)

    Anyah, R.; Semazzi, F.

    2009-04-01

    The International Center for Theoretical Physics(ICTP) regional climate model version 3(ICTP-RegCM3) multi-year simulations of East Africa rainfall during the October-December, short rains season are evaluated. Two parallel runs; based on NCEP reanalysis and NASA FvGCM lateral boundary conditions are performed. The simulated monthly and seasonal rainfall climatology as well as the inter-annual variability are found to be fairly consistent with observations. The model climatology over specific homogeneous climate sub-regions, except central Kenya highlands, also reasonably agree with the observed. The latitude-time evolution(intra-seasonal variability) of the simulated seasonal rainfall exhibits two distinct modes of behavior. The first is a quasi-stationary mode associated with high rainfall throughout the season within the equatorial belt between; 1oS and 2oN. The second mode is associated with the ITCZ-driven southward migration of regions of rainfall maxima as the season progresses, which is also consistent with the observed. Furthermore, observed rainfall variability over distinct homogeneous climate sub-regions is also fairly reproduced by the model, except over central Kenya Highlands and northeastern parts of Kenya. The spatial correlation between simulated seasonal rainfall and some of the global teleconnections(DMI and Nino3.4 indices) show that the regional model conserves some of the observed regional ‘hot spots' where rainfall-ENSO/DMI association are strong. At the same, unlike observations, the model reveals that along the East Africa Rift Valley and over western parts of Lake Victoria Basin, the association is weak, perhaps an indication that non-linear interactions between local forcing (captured by the model) and large scale systems either suppresses or obscures the dominant influence of the teleconnections on rainfall over certain parts.

  5. Customization of regional climate model (RegCM4) over Indian region

    Science.gov (United States)

    Nayak, S.; Mandal, M.; Maity, S.

    2017-01-01

    The regional climate model (RegCM4) is customized for 10-year climate simulation over Indian region through sensitivity studies on cumulus convection and land surface parameterization schemes. The model is configured over 30° E-120° E and 15° S-45° N at 30-km horizontal resolution with 23 vertical levels. Six 10-year (1991-2000) simulations are conducted with the combinations of two land surface schemes (BATS, CLM3.5) and three cumulus convection schemes (Kuo, Grell, MIT). The simulated annual and seasonal climatology of surface temperature and precipitation are compared with CRU observations. The interannual variability of these two parameters is also analyzed. The results indicate that the model simulated climatology is sensitive to the convection as well as land surface parameterization. The analysis of surface temperature (precipitation) climatology indicates that the model with CLM produces warmer (dryer) climatology, particularly over India. The warmer (dryer) climatology is due to the higher sensible heat flux (lower evapotranspiration) in CLM. The model with MIT convection scheme simulated wetter and warmer climatology (higher precipitation and temperature) with smaller Bowen ratio over southern India compared to that with the Grell and Kuo schemes. This indicates that a land surface scheme produces warmer but drier climatology with sensible heating contributing to warming where as a convection scheme warmer but wetter climatology with latent heat contributing to warming. The climatology of surface temperature over India is better simulated by the model with BATS land surface model in combination with MIT convection scheme while the precipitation climatology is better simulated with BATS land surface model in combination with Grell convection scheme. Overall, the modeling system with the combination of Grell convection and BATS land surface scheme provides better climate simulation over the Indian region.

  6. Know the Signs of Concussion

    Science.gov (United States)

    ... news/fullstory_167572.html Know the Signs of Concussion This serious health threat affects kids as well ... 2, 2017 WEDNESDAY, Aug. 2, 2017 (HealthDay News) -- Concussions have been in the news a lot because ...

  7. Signs and Symptoms of Mumps

    Science.gov (United States)

    ... Serology Publications and Resources Multimedia MMWR Articles Outbreak Articles Related Links World Health Organization Medline Plus Signs & Symptoms of Mumps Language: English Español (Spanish) Recommend on Facebook Tweet Share Compartir ...

  8. Diagnosing Dementia--Positive Signs

    Science.gov (United States)

    ... Navigation Bar Home Current Issue Past Issues Diagnosing Dementia—Positive Signs Past Issues / Fall 2007 Table of ... easy, affordable blood test that could accurately diagnose Alzheimer's disease (AD)—even before symptoms began to show? Researchers ...

  9. Triage of the Sign Problem

    CERN Document Server

    Splittorff, K

    2007-01-01

    We discuss the sign problem in QCD at nonzero chemical potential and its relation with chiral symmetry breaking and the spectrum of the Dirac operator using the framework of chiral random matrix theory. We show that the Banks-Casher formula is not valid for theories with a sign problem and has to be replaced by an alternative mechanism that is worked out in detail for QCD in one dimension at nonzero chemical potential.

  10. Role of Cumulus Parameterization Scheme on the Diurnal Cycle of Precipitation over Southeast Asia in RegCM4

    Science.gov (United States)

    Lui, Yuk Sing; Tam, Chi Yung Francis; Au-Yeung, Yee Man

    2017-04-01

    This study examines the sensitivity of precipitation simulations over the CORDEX-Southeast Asia (SEA) domain to the cumulus convection scheme used in the Regional Climate Model version 4 (RegCM4). With the ERA-interim reanalysis as lateral boundary conditions, model integrations using the MIT-Emanuel cumulus parameterization scheme, and those using a "mixed convection scheme" (namely with the MIT-Emanuel scheme over ocean and the Grell scheme with Arakawa Schubert-type closure over land), have been carried out for the 2001-2010 period. On the seasonal average, the use of the mixed convection scheme, in comparison to MIT-Emanuel scheme everywhere, improves rainfall simulations over the South China Sea (SCS) by reducing the summer-time wet bias there. On the other hand, runs with the mixed convection scheme under(over)-estimate rainfall over land in Southeastern China (western coastlines of Indochina and the Philippines). For the diurnal variation of precipitation, it is found that the RegCM4 can reproduce well the characteristics of the diurnal cycle (DC) in SEA. Compared with the mixed convection scheme, the MIT-Emanual scheme performs better in reproducing the amplitude and phase of DC over the landside coastal area of Indochina during summer. Empirical Orthogonal Function (EOF) analysis indicates that switching from the MIT-Emanuel scheme to the mixed convection scheme leads to a reduction in importance of the second EOF mode, which corresponds to rainfall peaked in the afternoon (local time). Further analyses reveal that such underestimation is related to increased cloud cover in RegCM4 using the mixed convection scheme; enhanced cloudiness in turn leads to reduced surface air temperature over land and thus reduced convective instability at 1200 and 1500 local time in the model simulations.

  11. Evaluation of the capability of RegCM4.0 in simulating East African climate

    Science.gov (United States)

    Ogwang, Bob Alex; Chen, Haishan; Li, Xing; Gao, Chujie

    2016-04-01

    The International Centre for Theoretical Physics (ICTP) regional climate model RegCM4.0 is used in this study to examine its ability to reproduce the climate of East Africa (EA) in regard to the annual cycle and June-to-August (JJA) seasonal climatology. Two domain sizes [large domain (LD) and small domain (SD)] and two cumulus convection schemes [Grell convection scheme with Fritsch-Chappell closure assumption (GRE scheme) and MIT scheme (EMA scheme)] are used. Simulations were done for the period 1989-2008 at a resolution of 50 km. The experiments were performed with the initial and lateral boundary conditions obtained from ERA-Interim-gridded reanalysis data at a 1.5° resolution. The variables investigated are precipitation, temperature, humidity, diurnal temperature range, and 850-hPa winds. Results show that the model realistically reproduces the East African climate, with a few discrepancies due to the different cumulus convection schemes and the domain sizes used. Grell with Fritsch-Chappell (Grell-FC) scheme captures well the observed climate in regard to the annual cycle and June-to-August seasonal climatology, with a tendency to underestimate rainfall over the JJA rainfall maximum region (RMR). This scheme performs better in LD than in SD. EMA scheme similarly captures well the observed climatology. It tends to overestimate rainfall over RMR. It however performs better in SD than in LD. The ensemble mean of simulations with GRE and EMA schemes (ENSM) tends to offer an improved representation of the observed climate, with a few discrepancies owing to the individual schemes used. In general, therefore, considering the performance of the model in both domains, the East African climate based on this study is better simulated by the Grell-FC scheme over LD. The observed biases in this study signify that the ability of the model in simulating climate over East Africa is still a significant challenge. Thus, future work must focus on improving the performance of

  12. Sensitivity of Precipitation over China to Diff erent Cumulus Parameterization Schemes in RegCM4

    Institute of Scientific and Technical Information of China (English)

    张少波; 吕世华; 鲍艳; 马迪

    2015-01-01

    The eff ect of diff erent cumulus parameterization schemes (CPSs) on precipitation over China is investi-gated by using the International Centre for Theoretical Physics (ICTP) Regional Climate Model version 4.3 (RegCM-4.3) coupled with the land surface model BATS1e (Biosphere-Atmosphere Transfer Scheme version 1e). The ERA-interim data are utilized to drive a group of simulations over a 31-yr period from September 1982 to December 2012. Two typically sensitive regions, i.e., the eastern Tibetan Plateau (TP; 29◦–38◦N, 90◦–100◦E) and eastern China (EC; 26◦–32◦N, 110◦–120◦E), are focused on. The results show that all the CPSs have well reproduced the spatial distribution of annual precipitation in China. The simulation with the Emanuel scheme shows an overall overestimation of precipitation in China, diff erent from the other three CPSs which only overestimate over northern and northwestern China but underestimate over southern China. Seasonally, the Tiedtke scheme shows the smallest overestimation in winter and summer, and the best simulation of the annual variance of precipitation. Interannual variations of precipitation among the four CPSs are generally simulated better in summer than in winter, and better for entire China than in the subregions of TP and EC. The precipitation trend is simulated better over EC than over TP, and better in summer than in winter. An overestimate (underestimate) of the East Asian summer monsoon index (EASMI) exists in the simulations with the Grell and the Emanuel (the Kuo and the Tiedtke) schemes. The smallest EASMI bias in the Tiedtke simulation could explain its small precipitation bias. A negative correlation between the EASMI and summer precipitation over the middle and lower reaches of Yangtze River is found in the Grell and the Emanuel simulations, but was missed by the simulations using the Kuo and the Tiedtke schemes.

  13. The interactions between anthropogenic aerosols and the East Asian summer monsoon using RegCCMS

    Science.gov (United States)

    Wang, T. J.; Zhuang, B. L.; Li, S.; Liu, J.; Xie, M.; Yin, C. Q.; Zhang, Y.; Yuan, C.; Zhu, J. L.; Ji, L. Q.; Han, Y.

    2015-06-01

    An online coupled regional climate-chemistry model called RegCCMS is used to investigate the interactions between anthropogenic aerosols and the East Asian summer monsoon (EASM) over East Asia. The simulation results show that the mean aerosol loading and optical depth over the region are 17.87 mg/m2 and 0.25, respectively. Sulfate and black carbon (BC) account for approximately 61.2% and 7.8% of the total aerosols, respectively. The regional mean radiative forcing (RF) is approximately -3.64, -0.55, and +0.88 W/m2 at the top of the atmosphere for the total aerosol effect, the total aerosol direct effect, and the BC direct effect, respectively. The surface direct RF of BC accounts for approximately 31% of the total RF of all aerosols. Because of the total aerosol effect, both the energy budgets and air temperature are considerably reduced in the region with high aerosol loadings, leading to decreases in the land-ocean air temperature gradient in summer. The total column-absorbed solar radiation and surface air temperature decrease by 8.4 W/m2 and 0.31 K, respectively. This cooling effect weakens horizontal and vertical atmospheric circulations over East Asia. The wind speed at 850 hPa decreases by 0.18 m/s, and the precipitation decreases by 0.29 mm/d. The small responses of solar radiation, air temperature, and atmospheric circulations to the BC warming effect are opposite to those of the total aerosol effect. The BC-induced enhancement of atmospheric circulation can increase local floods in south China, while droughts in north China may worsen in response to the BC semidirect effect. The total aerosol effect is much more significant than the BC direct effect. The East Asian summer monsoon becomes weaker due to the total aerosol effect. However, this weakness could be partially offset by the BC warming effect. Sensitivity analyses further indicate that the influence of aerosols on the EASM might be more substantial in years when the southerlies or southwesterlies

  14. Crab Orchard National Wildlife Refuge : Sign Plan

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The Crab Orchard National Wildlife Refuge Sign Plan explains how signs are used on the Refuge to help guide and educate visitors. An inventory of current signs is...

  15. Sign Plan : Necedah National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The Necedah National Wildlife Refuge Sign Plan explains how signs are used on the Refuge to help guide and educate visitors. An inventory of current signs is given...

  16. Sign Plan Squaw Creek National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The Squaw Creek National Wildlife Refuge Sign Plan explains how signs are used on the Refuge to help guide and educate visitors. An inventory of current signs is...

  17. Sign Plan Swan Lake National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The Swan Lake National Wildlife Refuge Sign Plan explains how signs are used on the Refuge to help guide and educate visitors. An inventory of current signs is...

  18. Sign Plan : Trempealeau National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The Trempealeau National Wildlife Refuge Sign Plan explains how signs are used on the Refuge to help guide and educate visitors. An inventory of current signs is...

  19. Sign Plan : Shiawassee National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The Shiawassee National Wildlife Refuge Sign Plan explains how signs are used on the Refuge to help guide and educate visitors. An inventory of current signs is...

  20. Chautauqua National Wildlife Refuge : Sign Plan

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The Chautauqua National Wildlife Refuge Sign Plan explains how signs are used on the Refuge to help guide and educate visitors. An inventory of current signs is...

  1. Zonas Francas y otros regímenes especiales en un contexto de negociaciones comerciales multilaterales y regionales

    OpenAIRE

    Jaime Granados

    2003-01-01

    Las zonas francas de exportación y otros regímenes especiales estarán siendo objeto de sustanciales reformas regulatorias como resultado de la progresiva inserción de los países en la economía internacional. Por un lado, los compromisos ante la Organización Mundial de Comercio (OMC) imponen la eliminación de los subsidios a la exportación. Por otro lado, los esquemas de integración regional normalmente imponen presiones para la eliminación de mecanismos de exoneración o reducción de aranceles...

  2. Interpretación prejudicial en procedimientos de arbitraje en los regímenes andino y europeo

    OpenAIRE

    Zúñiga Schroder, Humberto

    2015-01-01

    El presente artículo estará centrado en el análisis de la denominada “interpretación prejudicial” y en la eventual facultad de los tribunales arbitrales de solicitar esta, ya sea al Tribunal de Justicia de la Comunidad Andina (TJCA) o al Tribunal de Justicia de la Unión Europea. En consecuencia, este estudio será netamente comparativo; es decir, se incluirán paralelos entre los regímenes andino y europeo. El citado estudio será efectuado a la luz de la sentencia emitida en el proceso 03-AI-20...

  3. Proyectos Ecopetrol-PDVSA: Regímenes Petroleros, Seguridad Energética, Paralelos Eurasiáticos

    OpenAIRE

    Laszlo V. Palotas Kelen; Oscar Vanegas Angarita

    2011-01-01

    Este artículo se aproxima a los proyectos conjuntos de Ecopetrol y PDVSA a tres maneras: (a) Compara los regímenes petroleros de Venezuela y Colombia; (b) Analiza el significado de la seguridad energética para EE.UU, China, Venezuela y Colombia; (c) Busca analogías en la experiencia relativa a gasoductos/oleoductos eurasiáticos. Si esta experiencia fuera buen guía, EE.UU desaprobaría un oleoducto desde la Franja del Orinoco hasta la Costa Pacífica colombiana para exportar a China, y su oposic...

  4. RegA Plays a Key Role in Oxygen-Dependent Establishment of Persistence and in Isocitrate Lyase Activity, a Critical Determinant of In vivo Brucella suis Pathogenicity

    Directory of Open Access Journals (Sweden)

    Elias Abdou

    2017-05-01

    Full Text Available For aerobic human pathogens, adaptation to hypoxia is a critical factor for the establishment of persistent infections, as oxygen availability is low inside the host. The two-component system RegB/A of Brucella suis plays a central role in the control of respiratory systems adapted to oxygen deficiency, and in persistence in vivo. Using an original “in vitro model of persistence” consisting in gradual oxygen depletion, we compared transcriptomes and proteomes of wild-type and ΔregA strains to identify the RegA-regulon potentially involved in the set-up of persistence. Consecutive to oxygen consumption resulting in growth arrest, 12% of the genes in B. suis were potentially controlled directly or indirectly by RegA, among which numerous transcriptional regulators were up-regulated. In contrast, genes or proteins involved in envelope biogenesis and in cellular division were repressed, suggesting a possible role for RegA in the set-up of a non-proliferative persistence state. Importantly, the greatest number of the RegA-repressed genes and proteins, including aceA encoding the functional IsoCitrate Lyase (ICL, were involved in energy production. A potential consequence of this RegA impact may be the slowing-down of the central metabolism as B. suis progressively enters into persistence. Moreover, ICL is an essential determinant of pathogenesis and long-term interactions with the host, as demonstrated by the strict dependence of B. suis on ICL activity for multiplication and persistence during in vivo infection. RegA regulates gene or protein expression of all functional groups, which is why RegA is a key regulator of B. suis in adaptation to oxygen depletion. This function may contribute to the constraint of bacterial growth, typical of chronic infection. Oxygen-dependent activation of two-component systems that control persistence regulons, shared by several aerobic human pathogens, has not been studied in Brucella sp. before. This work

  5. Signed Networks in Social Media

    CERN Document Server

    Leskovec, Jure; Kleinberg, Jon

    2010-01-01

    Relations between users on social media sites often reflect a mixture of positive (friendly) and negative (antagonistic) interactions. In contrast to the bulk of research on social networks that has focused almost exclusively on positive interpretations of links between people, we study how the interplay between positive and negative relationships affects the structure of on-line social networks. We connect our analyses to theories of signed networks from social psychology. We find that the classical theory of structural balance tends to capture certain common patterns of interaction, but that it is also at odds with some of the fundamental phenomena we observe --- particularly related to the evolving, directed nature of these on-line networks. We then develop an alternate theory of status that better explains the observed edge signs and provides insights into the underlying social mechanisms. Our work provides one of the first large-scale evaluations of theories of signed networks using on-line datasets, as ...

  6. Climate-vegetation interactions in the coupled RegCM4 - CLM4.5 CNDV model

    Science.gov (United States)

    Caporaso, Luca; Giuliani, Graziano; Giorgi, Filippo

    2016-04-01

    We use the latest version of International Center for Theoretical Physics (ICTP) regional climate model (RegCM4) coupled with the Community Land Model version 4.5 (CLM4.5) including a dynamic vegetation model to study biogeophysical feedbacks in the climate system related to vegetation composition and structure. Sets of parallel experiments are conducted over the Africa and South America CORDEX domains using the RegCM4-CLM4.5 in its standard configuration and with the CNDV activated (CLM 4.5 with both the Carbon Nitrogen and the Dynamic Vegetation Model activated). The potential role of regional vegetation feedbacks within the climate system and the impact of climate variability and change on the ecosystem dynamics is assessed for both domains. In addition, the sensitivity to initial vegetation conditions and different idealized climate forcings is investigated. Preliminary results show that the changes in the climate forcing can have substantial effects on the dynamics and evolution of different vegetation types over both domains, and that the vegetation coupling can have a substantial effect on the simulated regional climate regimes. Our results thus indicate on the one hand that climate change can have profound effects on the evolution of important ecosystems for the two regions, and on the other that vegetation dynamics can indeed affect the climate response at the regional scale.

  7. The establishment and utility of Sweha-Reg: a Swedish population-based registry to understand hereditary angioedema

    Directory of Open Access Journals (Sweden)

    Werner Sonja

    2007-11-01

    Full Text Available Abstract Background The importance of acquiring comprehensive epidemiological and clinical data on hereditary angioedema has increasingly caught the attention of physicians and scientists around the world. The development of networks and creation of comprehensive policies to improve care of people suffering from rare diseases, such as hereditary angioedema, is a stated top priority of the European Union. Hereditary angioedema is a rare disease, that it may be life-threatening. Although the exact prevalence is unknown, current estimates suggest that it is 1/10,000–1/150,000 individuals. The low prevalence requires combined efforts to gain accurate epidemiological data on the disease and so give us tools to reduce morbidity and mortality, and improve quality of life of sufferers. Methods Sweha-Reg is a population-based registry of hereditary angioedema in Sweden with the objectives of providing epidemiological data, and so creates a framework for the study of this disease. The registry contains individual-based data on diagnoses, treatments and outcomes. Conclusion The present manuscript seeks to raise awareness of the existence of Sweha-Reg to stimulate the international collaboration of registries. A synthesis of data from similar registries across several countries is required to approach an inclusive course understanding of HAE.

  8. [EMPA-REG OUTCOME: Empagliflozin reduces mortality in patients with type 2 diabetes at high cardiovascular risk].

    Science.gov (United States)

    Scheen, A J

    2015-11-01

    EMPA-REG OUTCOME is an international, prospective, placebo-controlled clinical trial investigating the cardiovascular outcomes of empagliflozin, an inhibitor of sodium-glucose cotransporters type 2 (SGLT2), in patients with type 2 diabetes mellitus and known cardiovascular disease. The trial succeeded in reaching the primary objective of non-inferiority and, in addition, showed, after a median follow up of 3.1 years, a superiority of empagliflozin (10 or 25 mg/day) versus placebo as regards the primary composite cardiovascular endpoint (hasard ratio or HR = 0.86; 95% CI 0.74-0.99; P = 0.04), hospitalisations for heart failure (-35%), cardiovascular mortality (-38%) and all-cause mortality (-32%, each p < 0.001). The reductionin mortality appeared early (< 6 months) and concerned all subgroups, without any obvious heterogeneity. This reduction in mortality does not seem to be fully explained by the concomitant slight reductions in HbA1c, body weight, waist circumference, blood pressure and serum uric acid levels in the empagliflozin groups versus the placebo group. Finally, the tolerance and safety profile of empagliflozin was good, with only a moderate increase in benign mycotic genital infections, a well-known adverse event with SGLT2 inhibitors. The remarkable effects of empagliflozin in the EMPA-REG OUTCOME trial, especially on mortality, should modify the management of patients with type 2 diabetes and a high cardiovascular risk in a near future.

  9. Changes in inter-annual variability of precipitation and temperature over Mexico and Central America from RegCM projections

    Science.gov (United States)

    Fuentes-Franco, Ramon; Coppola, Erika; Tefera Diro, Gulilat; Giorgi, Filippo; Pavia, Edgar G.; Graef, Federico

    2013-04-01

    Future climate projections performed with the Regional Climate Model (RegCM4) are used to analyze the future changes on inter-annual variability of precipitation and temperature over Mexico and Central America. Two different global circulation models from the Couple Model Intercomparison Project phase 5 (CMPI5) are used as boundary conditions for two different RegCM4 configurations, which result in four different climate projections. Through a comparison of the precipitation annual cycles in reference period with future simulations, a shift in the annual cycle is found over Northwestern Mexico and Central America. During the rainy season (June to September), it is found an increase in the inter-annual variability of precipitation and temperature, together with a warming greater than 4°C in the mean seasonal temperature and a drying of more than 20%. An increased warming on the Eastern Pacific Ocean compared to the Tropical North Atlantic Ocean potentially generates a strengthened North Atlantic Subtropical High Pressure and also a stronger Caribbean Low Level Jet. This future ENSO-like state appears to be the mechanism driving the drying over the region

  10. Molten carbonate fuel cell product development test. Final report, September 30, 1992--March 31, 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-12-31

    This report summarizes the work performed for manufacturing and demonstrating the performance of its 250-kW molten carbonate fuel cell (MCFC) stack in an integrated system at the Naval Air Station Miramar (NAS Miramar) located in San Diego, California. The stack constructed for the demonstration test at the NAS Miramar consisted of 250 cells. It was manufactured using M-C Power`s patented Internally Manifolded Heat Exchanger (IMHEX{reg_sign}) stack design. The demonstration test at NAS Miramar was designed to operate the 250-kW MCFC stack in a cogeneration mode. This test represented the first attempt to thermally integrate an MCFC stack in a cogeneration system. The test was started on January 10, 1997, and voluntarily terminated on May 12, 1997, after 2,350 hours of operation at temperatures above 1,100 F and at a pressure of three atmospheres. It produced 160 MWh of d.c. power and 346,000 lbs of 110 psig steam for export during 1,566 hours of on-load operations. The test demonstrated a d.c. power output of 206 kW. Most of the balance of the plant (BOP) equipment operated satisfactorily. However, the off-the-shelf automotive turbocharger used for supplying air to the plant failed on numerous occasions and the hot gas blower developed seal leakage problems which impacted continuous plant operations. Overall the demonstration test at NAS Miramar was successful in demonstrating many critical features of the IMHEX technology. Lessons learned from this test will be very useful for improving designs and operations for future MCFC power plants.

  11. Compiling a Sign Language Dictionary

    DEFF Research Database (Denmark)

    Kristoffersen, Jette Hedegaard; Troelsgård, Thomas

    2010-01-01

    As we began working on the Danish Sign Language (DTS) Dictionary, we soon realised the truth in the statement that a lexicographer has to deal with problems within almost any linguistic discipline. Most of these problems come down to establishing simple rules, rules that can easily be applied eve...

  12. Signing Shakespeare: Romeo Loves Juliet.

    Science.gov (United States)

    Goldfarb, Liz; Cambridge, Terry

    1995-01-01

    A language arts teacher of junior high students with deafness or hearing impairments familiarized her students with "Romeo and Juliet" by telling the story in speech and signs, exploring the characters's personalities, reviewing vocabulary, putting the characters into contemporary situations, and directing the students in a full-scale production…

  13. Models as coherent sign structures

    NARCIS (Netherlands)

    Gazendam, H.W.M.; Jorna, R.J.J.M.; Gazendam, H.W.M.; Cijsouw, R.S.

    2003-01-01

    This chapter explains how models function as the glue that keeps organizations together. In an analysis of models from a semiotic and cognitive point of view, assumptions about evolutionary dynamics and bounded rationality are used. It is concluded that a model is a coherent sign structure,

  14. Symptom,sign and syndrome

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    2010381 Clinical and electrophysiological characteristics of Lambert-Eaton myasthenic syndrome:retrospective study in forty-five patients. GUAN Yuzhou(管宇宙),et al. Dept Neurol,PUMC & CAMS,Bejing 100730. Chin J Neurol 2010;331-334. Objective To analyze the symptoms and signs in forty-five Lambert-Eaton myasthenia syndrome (LEMS)patients

  15. Lexical Frequency in Sign Languages

    Science.gov (United States)

    Johnston, Trevor

    2012-01-01

    Measures of lexical frequency presuppose the existence of corpora, but true machine-readable corpora of sign languages (SLs) are only now being created. Lexical frequency ratings for SLs are needed because there has been a heavy reliance on the interpretation of results of psycholinguistic and neurolinguistic experiments in the SL research…

  16. iRegNet3D: three-dimensional integrated regulatory network for the genomic analysis of coding and non-coding disease mutations.

    Science.gov (United States)

    Liang, Siqi; Tippens, Nathaniel D; Zhou, Yaoda; Mort, Matthew; Stenson, Peter D; Cooper, David N; Yu, Haiyuan

    2017-01-18

    The mechanistic details of most disease-causing mutations remain poorly explored within the context of regulatory networks. We present a high-resolution three-dimensional integrated regulatory network (iRegNet3D) in the form of a web tool, where we resolve the interfaces of all known transcription factor (TF)-TF, TF-DNA and chromatin-chromatin interactions for the analysis of both coding and non-coding disease-associated mutations to obtain mechanistic insights into their functional impact. Using iRegNet3D, we find that disease-associated mutations may perturb the regulatory network through diverse mechanisms including chromatin looping. iRegNet3D promises to be an indispensable tool in large-scale sequencing and disease association studies.

  17. Microarray-based gene expression profiling reveals genes and pathways involved in the oncogenic function of REG3A on pancreatic cancer cells.

    Science.gov (United States)

    Xu, Qianqian; Fu, Rong; Yin, Guoxiao; Liu, Xiulan; Liu, Yang; Xiang, Ming

    2016-03-10

    We previously reported that regenerating islet-derived protein 3 alpha (REG3A) exacerbates pancreatic malignancies. The mechanism of this effect has not been clearly elucidated. Here we first identified key differentially expressed genes (DEGs) and signal pathways in the pancreatic cancer cell line SW1990, compared to two control cell lines, by microarray analysis. We then identified key genes and pathways regulated by REG3A or the cytokine IL6 in SW1990 cells. Afterwards, these DEGs induced by REG3A or IL6 were subjected to KEGG pathway enrichment analysis and GO function analysis by the DAVID online tool. Ultimately, we constructed protein-protein interaction networks among the DEGs by Cytoscape. Among the three pancreatic cell lines, SW1990 exhibited highly deterioration with the activation of genes and pathways related to proliferation, survival, angiogenesis, and invasion. As a result, 50 DEGs enriched in 11 pathways were identified in REG3A-treated SW1990 cells, and 28 DEGs enriched in 9 pathways were detected in IL6-treated cells. Overall, results of microarray analysis followed by qRT-PCR and Western blotting suggest that REG3A regulates pancreatic cell growth by increasing the expression of at least 8 genes: JAK1, STAT3, IL10, FOXM1, KRAS, MYC, CyclinD1, and c-fos; and activation of at least 4 signal pathways: TGFβ, PDGF, angiogenesis and RAS. Similar results were obtained with IL6 treatment. Regulation network analysis confirmed the cell growth related DEGs, and further uncovered three transcription factor families with immune functions regulated by REG3A.

  18. 47 CFR 2.302 - Call signs.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Call signs. 2.302 Section 2.302... RULES AND REGULATIONS Call Signs and Other Forms of Identifying Radio Transmissions § 2.302 Call signs. The table which follows indicates the composition and blocks of international call signs available...

  19. Eye Gaze in Creative Sign Language

    Science.gov (United States)

    Kaneko, Michiko; Mesch, Johanna

    2013-01-01

    This article discusses the role of eye gaze in creative sign language. Because eye gaze conveys various types of linguistic and poetic information, it is an intrinsic part of sign language linguistics in general and of creative signing in particular. We discuss various functions of eye gaze in poetic signing and propose a classification of gaze…

  20. Tactile Signing with One-Handed Perception

    Science.gov (United States)

    Mesch, Johanna

    2013-01-01

    Tactile signing among persons with deaf-blindness is not homogenous; rather, like other forms of language, it exhibits variation, especially in turn taking. Early analyses of tactile Swedish Sign Language, tactile Norwegian Sign Language, and tactile French Sign Language focused on tactile communication with four hands, in which partially blind or…

  1. Numeral Incorporation in Japanese Sign Language

    Science.gov (United States)

    Ktejik, Mish

    2013-01-01

    This article explores the morphological process of numeral incorporation in Japanese Sign Language. Numeral incorporation is defined and the available research on numeral incorporation in signed language is discussed. The numeral signs in Japanese Sign Language are then introduced and followed by an explanation of the numeral morphemes which are…

  2. Eye Gaze in Creative Sign Language

    Science.gov (United States)

    Kaneko, Michiko; Mesch, Johanna

    2013-01-01

    This article discusses the role of eye gaze in creative sign language. Because eye gaze conveys various types of linguistic and poetic information, it is an intrinsic part of sign language linguistics in general and of creative signing in particular. We discuss various functions of eye gaze in poetic signing and propose a classification of gaze…

  3. ProReg XL Tool: an easy-to-use computer tool suite for rapidly regrouping a large number of identical electrophoretic profiles.

    Science.gov (United States)

    Massias, Bastien; Urdaci, Maria C

    2009-05-01

    The ProReg XL Tool (Profile Regrouping Excel Tool) is a new tool suite designed to rapidly regroup a large number of identical electrophoretic profiles. This tool suite is coded in Visual Basic Application for Microsoft Excel, and thus requires this spreadsheet software to operate. It was designed for use with a new screening strategy of clones from an rrs (16S rDNA) clone library, but it may also be helpful in other electrophoretic applications. ProReg XL Tool is organized in different steps where the user has the capability--in addition to regrouping electrophoretic profiles--to control gel quality, determine signal attenuation, and draw pie charts.

  4. NordREG report on the price peaks in the Nordic wholesale market during winter 2009-2010. Final report

    Energy Technology Data Exchange (ETDEWEB)

    2011-01-15

    In winter 2009-2010, prices peaked on three days. The high prices that were experienced in the majority of the Nord Pool Spot price areas initiated a study on the reasons that led to the price spikes and on the possible measures to develop the Nordic market arrangements to avoid such situations in the future. The analysis of the winter 2009-2010 events revealed that there were a number of primary causes for the occurrence of the price peaks and no single individual cause could be pinpointed to bear the key responsibility. The fact that the weather was cold all over the Nordic area in conjunction with the low availability for the Swedish nuclear generation capacity, however, could be indicated as the key underlying causes. The analysis also showed that the way the Nordic transmission capacity is allocated can be listed as an additional factor complementing to the occurrence of the price peaks. Thus, NordREG concluded that a review of the methods of calculating and allocating transmission capacity for the market should be carried out. As a part of this, an analysis that addresses the delimitation of bidding areas and maintenance planning of the transmission network infrastructure should be prepared as well. The flexibility on the demand side has not been very large in the Nordic region. However, the background study prepared by Gaia Consulting showed that even small degree of increased price elasticity could substantially cut the price peaks. This could be seen as an improvement potential of the trading system reflecting the present inability of the market participants to react on the price signals the market place provides. Therefore, NordREG sees that facilitating the appearance of a real price elastic behaviour of the users of electricity can be regarded as one of the key fixes for the problem. Furthermore, NordREG proposes that a consultancy study on how to promote demand flexibility in the Nordic market in a coherent way should be prepared. A further area for

  5. Signed Networks in Social Media

    OpenAIRE

    Leskovec, Jure; Huttenlocher, Daniel; Kleinberg, Jon

    2010-01-01

    Relations between users on social media sites often reflect a mixture of positive (friendly) and negative (antagonistic) interactions. In contrast to the bulk of research on social networks that has focused almost exclusively on positive interpretations of links between people, we study how the interplay between positive and negative relationships affects the structure of on-line social networks. We connect our analyses to theories of signed networks from social psychology. We find that the c...

  6. Vital Signs-Secondhand Smoke

    Centers for Disease Control (CDC) Podcasts

    2015-02-03

    This podcast is based on the February 2015 CDC Vital Signs report. Secondhand smoke kills more than 400 infants and 41,000 adult nonsmokers every year. Learn what can be done to prevent secondhand smoke exposure.  Created: 2/3/2015 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 2/3/2015.

  7. Vital Signs - Child Passenger Safety

    Centers for Disease Control (CDC) Podcasts

    2014-02-04

    This podcast is based on the February 2014 CDC Vital Signs report. Over the past 10 years, more than 9,000 children 12 and under died in motor vehicle crashes, and a third who died in 2011 weren't buckled up. Buckling up is the best way to reduce injuries and save lives.  Created: 2/4/2014 by National Center for Injury Prevention and Control (NCIPC).   Date Released: 2/4/2014.

  8. Low Cost Reversible Signed Comparator

    Directory of Open Access Journals (Sweden)

    Farah Sharmin

    2013-10-01

    Full Text Available Nowadays exponential advancement in reversible comp utation has lead to better fabrication and integration process. It has become very popular ove r the last few years since reversible logic circuit s dramatically reduce energy loss. It consumes less p ower by recovering bit loss from its unique input-o utput mapping. This paper presents two new gates called RC-I and RC-II to design an n-bit signed binary comparator where simulation results show that the p roposed circuit works correctly and gives significa ntly better performance than the existing counterparts. An algorithm has been presented in this paper for constructing an optimized reversible n-bit signed c omparator circuit. Moreover some lower bounds have been proposed on the quantum cost, the numbers of g ates used and the number of garbage outputs generated for designing a low cost reversible sign ed comparator. The comparative study shows that the proposed design exhibits superior performance consi dering all the efficiency parameters of reversible logic design which includes number of gates used, quantum cost, garbage output and constant inputs. This proposed design has certainly outperformed all the other existing approaches.

  9. Road and Street Centerlines, MDTA Road Signs like Stop signs, Toll signs, Roadway Signs, Stop Signs, Toll signs, Overhead signs, Published in 2010, 1:1200 (1in=100ft) scale, Maryland Transportation Authority.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — , published at 1:1200 (1in=100ft) scale, was produced all or in part from Field Survey/GPS information as of 2010. It is described as 'MDTA Road Signs like Stop...

  10. The Role of Sign Phonology and Iconicity During Sign Processing: The Case of Deaf Children

    NARCIS (Netherlands)

    Ormel, E.A.; Hermans, D.; Knoors, H.E.T.; Verhoeven, L.T.W.

    2009-01-01

    To investigate the influence of sign phonology and iconicity during sign processing in deaf children, the roles of these sign features were examined using an experimental sign-picture verification paradigm. Participants had to make decisions about sign-picture pairs, manipulated according to

  11. Efectividad de cepas rizobianas de frijolbajo diferentes regímenes de fósforo

    Directory of Open Access Journals (Sweden)

    Juliana Mayz Figueroa

    2012-06-01

    Full Text Available Normal 0 21 false false false ES-CO X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabla normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin-top:0cm; mso-para-margin-right:0cm; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0cm; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin;} Título en ingles: Effectiveness of cowpea rhizobial strains under different phosphorus regimes Resumen En Venezuela, el frijol representa una alternativa a la proteína animal, debido a su alto consumo y valor nutritivo, por ello se ha estimulado la implementación de programas para reactivar la economía de los pequeños y medianos productores, a fin de incrementar su producción y así tener mayor disponibilidad de proteína de alta calidad a  bajo costo; de manera que, los estudios encaminados a mejorar su cultivo, son acertados. Se evaluó la efectividad de cepas rizobianas de crecimiento lento (cl y rápido (cr en frijol (Vigna unguiculata (L. Walp. cultivar TC9-6 en varios regímenes de fósforo (0, 20, 40 y 80 kgP2O5 ha-1, con un diseño experimental de bloques al azar con arreglo factorial. Las plantas se cultivaron en 4 kg de suelo de sabana 45 días y las cepas en caldo de levadura y manitol: 5 (cr: JV91 y 10 (cl: JV94 días. La inoculación (2 ml cada vez fue aplicada a la siembra y 6 días más tarde. La utilización de fósforo (40-80 kgP2O5 ha-1 incrementó la nodulación (número, peso seco total e individual de nódulos y favoreció la aparición de nódulos rojos; así mismo, acrecent

  12. Los excerpta de Beda (De Temporum Ratione 19 y 23 en Ripoll (ACA, Ripoll 59 y Vat. Reg. Lat. 123

    Directory of Open Access Journals (Sweden)

    José Martínez Gázquez

    1996-12-01

    Full Text Available The analysis of texts and glossaries contained in the manuscript ACA Ripoll 59 reveals various compilations of glossaries and «computation» texts, besides Priscian's grammar, which is the most important text in the manuscript. The analysis and identification of the fragments in ACA Ripoll 59 the same as those in Vat. Reg. Lat. 123, which also belongs to the manuscripts found in Ripoll, corresponding to various chapters of Beda, allow us to study the different currents that exerted their cultural influence in the Monastery of Santa Maria de Ripoll. Through the variants established for each of the texts that have been identified, one detects the influence of various families of manuscripts in the composition of these fragments.

  13. A rapid and efficient preparation of [{sup 123}I]radiopharmaceuticals using a small HPLC Rocket[reg] column

    Energy Technology Data Exchange (ETDEWEB)

    Katsifis, Andrew [Radiopharmaceuticals Division R and D, Australian Nuclear Science and Technology, Organisation, Menai, NSW 2234, Sydney (Australia)]. E-mail: akx@ansto.gov.au; Papazian, Vahan [Radiopharmaceuticals Division R and D, Australian Nuclear Science and Technology, Organisation, Menai, NSW 2234, Sydney (Australia); Jackson, Timothy [Radiopharmaceuticals Division R and D, Australian Nuclear Science and Technology, Organisation, Menai, NSW 2234, Sydney (Australia); Loc' h, Christian [Radiopharmaceuticals Division R and D, Australian Nuclear Science and Technology, Organisation, Menai, NSW 2234, Sydney (Australia)

    2006-01-01

    A simplified method for the rapid and efficient preparation of [{sup 123}I]radiopharmaceuticals is described. Three radiopharmaceuticals, [{sup 123}I]{beta}-CIT, [{sup 123}I]MIBG and [{sup 123}I]clioquinol, were synthesised and purified as model compounds. The radiotracers were labelled with iodine-123 using electrophilic oxidative conditions and purified by a compact semi-preparative reverse phase column (C-18, 3 {mu}m, 7x53 mm, Alltima Rocket[reg, Alltech] using aqueous-ethanol as HPLC solvents that were directly used for radiopharmaceutical formulation. The radiochemical purity of the radioiodinated tracers as assessed by analytical HPLC was higher than 99% with specific activity higher than 3 GBq/nmol. The total preparation time of a radiotracer ranged from 40 to 60 min and, starting from 3.7 GBq of iodine-123, more than 2.5 GBq of formulated radiopharmaceuticals were available for clinical investigations.

  14. Proyectos Ecopetrol-PDVSA: Regímenes Petroleros, Seguridad Energética, Paralelos Eurasiáticos

    Directory of Open Access Journals (Sweden)

    Laszlo V. Palotas Kelen

    2011-01-01

    Full Text Available Este artículo se aproxima a los proyectos conjuntos de Ecopetrol y PDVSA a tres maneras: (a Compara los regímenes petroleros de Venezuela y Colombia; (b Analiza el significado de la seguridad energética para EE.UU, China, Venezuela y Colombia; (c Busca analogías en la experiencia relativa a gasoductos/oleoductos eurasiáticos. Si esta experiencia fuera buen guía, EE.UU desaprobaría un oleoducto desde la Franja del Orinoco hasta la Costa Pacífica colombiana para exportar a China, y su oposición retardaría el proyecto, pero no necesariamente impediría su realización.

  15. Detecting changes in future precipitation extremes over eight river basins in China using RegCM4 downscaling

    Science.gov (United States)

    Qin, Peihua; Xie, Zhenghui

    2016-06-01

    To detect the frequency and intensity of precipitation extremes in China for the middle 21st century, simulations were conducted with the regional climate model RegCM4 forced by the global climate model GFDL_ESM2M under the middle emission scenario (RCP4.5). Compared with observed precipitation extremes for the reference period from 1982 to 2001, RegCM4 generally performed better in most river basins of China relative to GFDL. In the future period 2032-2051, more wet extremes will occur relative to the present period in most study areas, especially in southeast China while significantly less dry extremes will occur in arid and semiarid areas in northwest China. In contrast, areas in northwest China showed an increase in the trend of dry extremes (CDD) and a decrease in the trend of wet extremes (R95p and Rx5day), which might result in more drought in the future. Finally, we discuss in detail the possible reason of these processes, such as zonal wind, vertical wind, and water vapor. In the Huaihe river basin (HU), reduced south winds in summer (June-August) and a decrease of the upward vertical p velocity cause less future precipitation and might lead to changes of extreme events. We also completed correlation analysis between the precipitation extreme indices and the climate factors and found that the precipitation extremes were more sensitive to the annual and seasonal mean precipitation, total water vapor, and upward vertical wind relative to the geopotential height and 2 m temperature over most river basins in China. Perhaps the changes of some wet extremes could be verified partly through changes of annual precipitation due to their high consistence.

  16. Rainfall and temperature scenarios for Bangladesh for the middle of 21st century using RegCM

    Indian Academy of Sciences (India)

    Md Mizanur Rahman; Md Nazrul Islam; Ahsan Uddin Ahmed; F Georgi

    2012-04-01

    Regional Climate Model of version 3 (RegCM3) was driven with Emissions Scenarios A2 of ECHAM4 at 0.54° × 0.54° horizontal grid resolution in two parameterizations: Grell scheme with Arakawa–Schubert (GAS) and Fritch–Chappell (GFC) assumptions. The simulated rainfall and mean surface air temperature were calibrated and validated against ground-based observed data in Bangladesh during the period 1961–1990. The Climate Research Unit (CRU) data is also used for understanding the model performance. Better performance of RegCM3 obtained through validation process, made it confident in utilizing it in rainfall and temperature projection for Bangladesh in the middle of 21st century. Rainfall and mean surface air temperature projection for Bangladesh is experimentally obtained for 2050 and 2060. This work discloses that simulated rainfall and temperature are not directly useful in application-oriented tasks. However, after calibration and validation, reasonable performance can be obtained in estimating seasonal and annual rainfall, and mean surface air temperature in Bangladesh. The projected change of rainfall for Bangladesh is about +35% for monsoon season (JJAS), −67% for pre-monsoon (MAM), −12% for post-monsoon (ON) and 107% for winter (DJF) for 2050. On an average, rainfall may be less by more than 50% for all seasons for the year 2060. Similarly, change of mean surface air temperature in different months is projected about 0.5°–2.1°C and 0.9°–3.5°C for the year 2050 and 2060, respectively.

  17. Comparison of early complications using regular mesh versus Atramat and reg; Neoflex 25 mesh in inguinal, umbilical and post incisional hernias

    Directory of Open Access Journals (Sweden)

    Juan Jos and eacute; Granados-Romero

    2016-01-01

    Conclusions: Using Atramat and reg; Neoflex 25 mesh demonstrated a significant reduction of complications (recurrence and seroma formation and length of hospital stay (2 days vs 1 day in abdominoplasty after surgery. [Int J Res Med Sci 2016; 4(1.000: 194-197

  18. Expression of Gast, Cckbr, Reg1α genes in rat duodenal epithelial cells upon long-term gastric hypoacidity and after a multiprobiotic administration

    Directory of Open Access Journals (Sweden)

    Dranitsina A. S.

    2014-11-01

    Full Text Available Aim. Determination of the Cckbr, Gast and Reg1α genes expression in rat duodenal epithelial cells upon long- term hypoacidity and with the administration of the multiprobiotic Symbiter. Methods. The experiments were carried out on white non-strain male rats. The hypoacidic state was induced through intraperitoneal injection of omeprazole for 28 days. The level of genes expression was determined by semi-quantitative analysis with RT-PCR Results. The elevation of mRNA levels of the Cckbr and Gast genes in rat duodenal villus and crypt epitheliocytes, the increased expression of the Reg1A gene in crypt epithelial cells were shown as well as the appearance of the Reg1a gene expression in villus epitheliocytes upon hypoacidic conditions were shown. The content of mRNAs of the above mentioned genes decreased or remained at the control level upon the treatment of hypoacidic rats with the multiprobiotic Symbiter. Conclusions. Long-term gastric hypoacidity is accompanied by the changes in expression of the Cckbr, Gast and Reg1a genes in rat duodenum, whereas upon administration of the multiprobiotic Symbiter the pattern of studied gene expression did not changed in the most cases.

  19. A novel upregulation of glutathione peroxidase 1 by knockout of liver-regenerating protein Reg3β aggravates acetaminophen-induced hepatic protein nitration.

    Science.gov (United States)

    Yun, Jun-Won; Lum, Krystal; Lei, Xin Gen

    2013-12-01

    Murine regenerating islet-derived 3β (Reg3β) represents a homologue of human hepatocarcinoma-intestine-pancreas/pancreatic-associated protein and enhances mouse susceptibility to acetaminophen (APAP)-induced hepatotoxicity. Our objective was to determine if and how knockout of Reg3β (KO) affects APAP (300 mg/kg, ip)-mediated protein nitration in mouse liver. APAP injection produced greater levels of hepatic protein nitration in the KO than in the wild-type mice. Their elevated protein nitration was alleviated by a prior injection of recombinant mouse Reg3β protein and was associated with an accelerated depletion of the peroxynitrite (ONOO(-)) scavenger glutathione by an upregulated hepatic glutathione peroxidase-1 (GPX1) activity. The enhanced GPX1 production in the KO mice was mediated by an 85% rise (pnitration and a new biosynthesis control of GPX1 by a completely "unrelated" regenerating protein, Reg3β, via transcriptional activation of Scly in coping with hepatic protein nitration. Linking selenoproteins to tissue regeneration will have profound implications in understanding the mechanism of Se functions and physiological coordination of tissue regeneration with intracellular redox control. Copyright © 2013 Elsevier Inc. All rights reserved.

  20. Vital Signs-Trucker Safety

    Centers for Disease Control (CDC) Podcasts

    2015-03-03

    This podcast is based on the March 2015 CDC Vital Signs report. In 2012 in the United States, about 317,000 motor vehicle crashes involved a large truck. Twenty-six thousand truck drivers and their passengers were injured in these crashes, and about 700 died. Learn what can be done to help truck drivers stay safe.  Created: 3/3/2015 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 3/3/2015.

  1. Analysis of the present and future winter Pacific-North American teleconnection in the ECHAM5 global and RegCM3 regional climate models

    Science.gov (United States)

    Allan, Andrea M.; Hostetler, Steven W.; Alder, Jay R.

    2014-01-01

    We use the NCEP/NCAR Reanalysis (NCEP) and the MPI/ECHAM5 general circulation model to drive the RegCM3 regional climate model to assess the ability of the models to reproduce the spatiotemporal aspects of the Pacific-North American teleconnection (PNA) pattern. Composite anomalies of the NCEP-driven RegCM3 simulations for 1982–2000 indicate that the regional model is capable of accurately simulating the key features (500-hPa heights, surface temperature, and precipitation) of the positive and negative phases of the PNA with little loss of information in the downscaling process. The basic structure of the PNA is captured in both the ECHAM5 global and ECHAM5-driven RegCM3 simulations. The 1950–2000 ECHAM5 simulation displays similar temporal and spatial variability in the PNA index as that of NCEP; however, the magnitudes of the positive and negative phases are weaker than those of NCEP. The RegCM3 simulations clearly differentiate the climatology and associated anomalies of snow water equivalent and soil moisture of the positive and negative PNA phases. In the RegCM3 simulations of the future (2050–2100), changes in the location and extent of the Aleutian low and the continental high over North America alter the dominant flow patterns associated with positive and negative PNA modes. The future projections display a shift in the patterns of the relationship between the PNA and surface climate variables, which suggest the potential for changes in the PNA-related surface hydrology of North America.

  2. Distinct cell clusters touching islet cells induce islet cell replication in association with over-expression of Regenerating Gene (REG protein in fulminant type 1 diabetes.

    Directory of Open Access Journals (Sweden)

    Kaoru Aida

    Full Text Available BACKGROUND: Pancreatic islet endocrine cell-supporting architectures, including islet encapsulating basement membranes (BMs, extracellular matrix (ECM, and possible cell clusters, are unclear. PROCEDURES: The architectures around islet cell clusters, including BMs, ECM, and pancreatic acinar-like cell clusters, were studied in the non-diabetic state and in the inflamed milieu of fulminant type 1 diabetes in humans. RESULT: Immunohistochemical and electron microscopy analyses demonstrated that human islet cell clusters and acinar-like cell clusters adhere directly to each other with desmosomal structures and coated-pit-like structures between the two cell clusters. The two cell-clusters are encapsulated by a continuous capsule composed of common BMs/ECM. The acinar-like cell clusters have vesicles containing regenerating (REG Iα protein. The vesicles containing REG Iα protein are directly secreted to islet cells. In the inflamed milieu of fulminant type 1 diabetes, the acinar-like cell clusters over-expressed REG Iα protein. Islet endocrine cells, including beta-cells and non-beta cells, which were packed with the acinar-like cell clusters, show self-replication with a markedly increased number of Ki67-positive cells. CONCLUSION: The acinar-like cell clusters touching islet endocrine cells are distinct, because the cell clusters are packed with pancreatic islet clusters and surrounded by common BMs/ECM. Furthermore, the acinar-like cell clusters express REG Iα protein and secrete directly to neighboring islet endocrine cells in the non-diabetic state, and the cell clusters over-express REG Iα in the inflamed milieu of fulminant type 1 diabetes with marked self-replication of islet cells.

  3. Grandfather Moose: Sign Language Nursery Rhymes.

    Science.gov (United States)

    Hamilton, Harley

    1987-01-01

    "Grandfather Moose" rhymes, written to follow the Mother Goose tradition, are short, appealing, easy-to-memorize sign language nursery rhymes which employ visual poetic devices such as similar signs and transitional flow of movement. (CB)

  4. CDC Vital Signs: Motor Vehicle Crash Deaths

    Science.gov (United States)

    ... government is Tracking the nation’s progress in reducing crash injuries and deaths. www.cdc.gov/psr/national-summary/ ... Motor Vehicle Crash Deaths Vital Signs: Motor Vehicle Crash Injuries Vital Signs: Child Passenger Safety CDC: Child Passenger ...

  5. South African sign language assistive translation

    CSIR Research Space (South Africa)

    Olivrin, GJ

    2008-04-01

    Full Text Available The authors describe a novel approach and practical solution to an interactive sign language machine translation system from English to South African Sign Language. They interface the system with the GNApp application, which is an augmentative...

  6. Mark Twain National Wildlife Refuge: Sign Plan

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The Mark Twain NWR (including the Louisa District, the Annada District, and the Brussels District) Sign Plan explains how signs are used on the Refuge to help guide...

  7. Signs and Symptoms of Untreated Lyme Disease

    Science.gov (United States)

    ... FAQ Health care providers Educational materials Signs and Symptoms of Untreated Lyme Disease Recommend on Facebook Tweet ... area where Lyme disease occurs . Early Signs and Symptoms (3 to 30 days after tick bite) Fever, ...

  8. Signs and Symptoms of Mood Disorders

    Science.gov (United States)

    ... Public Service Announcements Partnering with DBSA Signs and Symptoms of Mood Disorders Depression and bipolar disorder (also ... a Confidential Online Mood Disorder Screening Signs and symptoms of depression Prolonged sadness or unexplained crying spells ...

  9. Cooperative Sign Language Tutoring: A Multiagent Approach

    Science.gov (United States)

    Yıldırım, Ilker; Aran, Oya; Yolum, Pınar; Akarun, Lale

    Sign languages can be learned effectively only with frequent feedback from an expert in the field. The expert needs to watch a performed sign, and decide whether the sign has been performed well based on his/her previous knowledge about the sign. The expert's role can be imitated by an automatic system, which uses a training set as its knowledge base to train a classifier that can decide whether the performed sign is correct. However, when the system does not have enough previous knowledge about a given sign, the decision will not be accurate. Accordingly, we propose a multiagent architecture in which agents cooperate with each other to decide on the correct classification of performed signs. We apply different cooperation strategies and test their performances in varying environments. Further, through analysis of the multiagent system, we can discover inherent properties of sign languages, such as the existence of dialects.

  10. Signed Young Modules and Simple Specht Modules

    OpenAIRE

    Danz, Susanne; Lim, Kay Jin

    2015-01-01

    By a result of Hemmer, every simple Specht module of a finite symmetric group over a field of odd characteristic is a signed Young module. While Specht modules are parametrized by partitions, indecomposable signed Young modules are parametrized by certain pairs of partitions. The main result of this article establishes the signed Young module labels of simple Specht modules. Along the way we prove a number of results concerning indecomposable signed Young modules that are of independent inter...

  11. Irreducible Specht modules are signed Young modules

    OpenAIRE

    Hemmer, David J.

    2005-01-01

    Recently Donkin defined signed Young modules as a simultaneous generalization of Young and twisted Young modules for the symmetric group. We show that in odd characteristic, if a Specht module $S^\\lambda$ is irreducible, then $S^\\lambda$ is a signed Young module. Thus the set of irreducible Specht modules coincides with the set of irreducible signed Young modules. This provides evidence for our conjecture that the signed Young modules are precisely the class of indecomposable self-dual module...

  12. Sign (di)Lemma for Dimension Shifting

    Indian Academy of Sciences (India)

    Nitin Nitsure

    2009-04-01

    There is a surprising occurrence of some minus signs in the isomorphisms produced in the well-known technique of dimension shifting in calculating derived functors in homological algebra. We explicitly determine these signs. Getting these signs right is important in order to avoid basic contradictions. We illustrate the result – which we call as the sign lemma for dimension shifting – by some de Rham cohomology and Chern class considerations for compact Riemann surfaces.

  13. Cutaneous signs of classical dermatomyositis.

    Science.gov (United States)

    Auriemma, M; Capo, A; Meogrossi, G; Amerio, P

    2014-10-01

    Idiopathic immune myopathies (IIM) are an heterogeneous group of autoimmune muscle disorders characterized by progressive muscle involvement. Dermatomyositis (DM) is the most common form of IIM. It is a multisystem disorder characterized by symmetric proximal, extensor, inflammatory myopathy, vascular involvement and a characteristic cutaneous eruption. Six types of DM have been identified: idiopathic, juvenile (JDM), cancer-related other autoimmune diseases-related, iatrogenic DM and amyopathic DM. Cutaneous manifestations of DM are the most important aspect of this disease and can precede from several months to years muscle or systemic involvement. Three groups of signs have been described: pathognomonic, highly characteristic and compatible. Although differences exist among the different clinical presentation of skin lesions, they share common histological findings including the presence of interface dermatitis with epidermal atrophy, basement membrane degeneration, vacuolar alteration of basal keratinocytes, and dermal changes consisting of interstitial mucin deposition and a sparse lymphocytic infiltrate. DM is a serious disease; the correct evaluation of any skin lesion suggesting an early diagnosis is of utmost importance. Skin signs may, also, represent a marker of treatment efficacy even though systemic symptoms worsening may not always be followed by more severe skin lesions.

  14. 30 CFR 56.12021 - Danger signs.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Danger signs. 56.12021 Section 56.12021 Mineral... HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Electricity § 56.12021 Danger signs. Suitable danger signs shall be posted at all major electrical installations....

  15. 30 CFR 57.12021 - Danger signs.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Danger signs. 57.12021 Section 57.12021 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND... Underground § 57.12021 Danger signs. Suitable danger signs shall be posted at all major...

  16. Mark Twain National Wildlife Refuge : Sign Plan

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The Mark Twain NWR Sign Plan explains how signs are used on the Refuge to help guide and educate visitors. An inventory of current signs is given as well as a list...

  17. Sign Plan : Seney National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The Seney NWR Sign Plan explains how signs are used on the Refuge to help guide and educate visitors. An inventory of current signs is given as well as a list of...

  18. Smart Signs Show You the Way

    NARCIS (Netherlands)

    Lijding, M.E.M.; Meratnia, N.; Benz, H.P.; Matysiak Szóstek, A.

    2007-01-01

    Smart Signs are a new type of electronic door and way signs based on small computers which can be seamlessly incorporated in the environment. Smart Signs provide personalized context-aware guidance and messaging designed to support wayfinding activities in large indoor spaces and their surroundings.

  19. Sign Plan : Sherburne National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The Sherburne NWR Sign Plan explains how signs are used on the Refuge to help guide and educate visitors. An inventory of current signs is given as well as a list...

  20. Sign Plan: Kenai National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The Kenai NWR Sign Plan explains how signs are used on the Refuge to help guide and educate visitors. An inventory of current signs is given as well as a list of...

  1. Sign Plan : Mingo National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The Mingo NWR Sign Plan explains how signs are used on the Refuge to help guide and educate visitors. An inventory of current signs is given as well as a list of...

  2. How many Babinski's signs are there?

    Science.gov (United States)

    Kakitani, Fabio T; Collares, Daniel; Kurozawa, Adam Y; Lima, Plínio M G de; Teive, Hélio A G

    2010-08-01

    In addition to the famous sign described by Joseph Babinski, which is also known as Babinski's reflex, there are references in the literature to various other signs described by this famous disciple of J-M Charcot. This article reviews all the neurological signs described by Babinski.

  3. Smart Signs Show You the Way

    NARCIS (Netherlands)

    Lijding, M.E.M.; Meratnia, Nirvana; Benz, H.P.; Matysiak Szóstek, A.

    Smart Signs are a new type of electronic door and way signs based on small computers which can be seamlessly incorporated in the environment. Smart Signs provide personalized context-aware guidance and messaging designed to support wayfinding activities in large indoor spaces and their surroundings.

  4. Sign Plan : Big Stone National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The Big Stone NWR Sign Plan explains how signs are used on the Refuge to help guide and educate visitors. An inventory of current signs is given as well as a list of...

  5. Dictionaries of African Sign Languages: An Overview

    Science.gov (United States)

    Schmaling, Constanze H.

    2012-01-01

    This article gives an overview of dictionaries of African sign languages that have been published to date most of which have not been widely distributed. After an introduction into the field of sign language lexicography and a discussion of some of the obstacles that authors of sign language dictionaries face in general, I will show problems…

  6. Sign Language Planning: Pragmatism, Pessimism and Principles

    Science.gov (United States)

    Turner, Graham H.

    2009-01-01

    This article introduces the present collection of sign language planning studies. Contextualising the analyses against the backdrop of core issues in the theory of language planning and the evolution of applied sign linguistics, it is argued that--while the sociolinguistic circumstances of signed languages worldwide can, in many respects, be…

  7. The Legal Recognition of Sign Languages

    Science.gov (United States)

    De Meulder, Maartje

    2015-01-01

    This article provides an analytical overview of the different types of explicit legal recognition of sign languages. Five categories are distinguished: constitutional recognition, recognition by means of general language legislation, recognition by means of a sign language law or act, recognition by means of a sign language law or act including…

  8. A Segmental Framework for Representing Signs Phonetically

    Science.gov (United States)

    Johnson, Robert E.; Liddell, Scott K.

    2011-01-01

    The arguments for dividing the signing stream in signed languages into sequences of phonetic segments are compelling. The visual records of instances of actually occurring signs provide evidence of two basic types of segments: postural segments and trans-forming segments. Postural segments specify an alignment of articulatory features, both manual…

  9. Parker River National Wildlife Refuge : Sign Plan

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The Parker River NWR Sign Plan explains how signs are used on the Refuge to help guide and educate visitors. An inventory of current signs is given as well as a list...

  10. Research on the Translation of Public Signs

    Science.gov (United States)

    Qiannan, Ma

    2012-01-01

    Because of the increasing international image of China, the translation of public signs in city has become the very important issue. From the point of view of cross-cultural communication, the public signs have crucial influence on the image of the city, even for the whole China. However, there exist many translation errors of the public signs in…

  11. Sign Plan : Minnesota Valley National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The Minnesota Valley NWR Sign Plan explains how signs are used on the Refuge to help guide and educate visitors. An inventory of current signs is given as well as a...

  12. Dictionaries of African Sign Languages: An Overview

    Science.gov (United States)

    Schmaling, Constanze H.

    2012-01-01

    This article gives an overview of dictionaries of African sign languages that have been published to date most of which have not been widely distributed. After an introduction into the field of sign language lexicography and a discussion of some of the obstacles that authors of sign language dictionaries face in general, I will show problems…

  13. On the ability of RegCM4 to simulate surface solar radiation patterns over Europe: An assessment using satellite-based observations

    Science.gov (United States)

    Alexandri, Georgia; Georgoulias, Aristeidis K.; Zanis, Prodromos; Tsikerdekis, Athanasios; Katragkou, Eleni; Kourtidis, Konstantinos; Meleti, Charikleia

    2015-04-01

    We assess here the ability of RegCM4 to simulate the surface solar radiation (SSR) patterns over the European domain. For the needs of this work, a decadal (1999-2009) simulation was implemented at a horizontal resolution of 50km using the first year as a spin-up. The model is driven by emissions from CMIP5 while ERA-interim data were used as lateral boundary conditions. The RegCM4 SSR fields were validated against satellite-based SSR observations from Meteosat First Generation (MFG) and Meteosat Second Generation (MSG) sensors (CM SAF SIS product). The RegCM4 simulations slightly overestimate SSR compared to CM SAF over Europe with the bias being +1.54% in case of MFG (2000-2005) and +3.34% in case of MSG (2006-2009). SSR from RegCM4 is much closer to SSR from CM SAF over land (bias of -1.59% for MFG and +0.66% for MSG) than over ocean (bias of +7.20% for MFG and 8.07% for MSG). In order to understand the reasons of this bias, we proceeded to a detailed assessment of various parameters that define the SSR levels (cloud fractional cover - CFC, cloud optical thickness - COT, cloud droplet effective radius - Re, aerosol optical thickness - AOD, asymmetry factor - ASY, single scattering albedo - SSA, water vapor - WV and surface albedo - ALB). We validated the simulated CFC, COT and Re from RegCM4 against satellite-based observations from MSG and we found that RegCM4 significantly underestimates CFC and Re, and overestimates COT over Europe. The aerosol-related parameters from RegCM4 were compared with values from the aerosol climatology taken into account within CM SAF SSR estimates. AOD is significantly underestimated in our simulations which leads to a positive SSR bias. The RegCM4 WV and ALB were compared with WV values from ERA-interim and ALB climatological observations from CERES which are also taken into account within CM SAF SSR estimates. Finally, with the use of a radiative transfer model (SBDART) we manage to quantify the relative contribution of each of

  14. Previsões climáticas sazonais sobre o Brasil: avaliação do RegCM3 aninhado no modelo global CPTEC/COLA Seasonal climatic forecast over Brazil: evaluation of the RegCM3 model nested to the CPTEC/COLA global model

    Directory of Open Access Journals (Sweden)

    Rubinei Dorneles Machado

    2011-03-01

    Full Text Available Este trabalho avalia o desempenho de previsões sazonais do modelo climático regional RegCM3, aninhado ao modelo global CPTEC/COLA. As previsões com o RegCM3 utilizaram 60 km de resolução horizontal num domínio que inclui grande parte da América do Sul. As previsões do RegCM3 e CPTEC/COLA foram avaliadas utilizando as análises de chuva e temperatura do ar do Climate Prediction Center (CPC e National Centers for Enviromental Prediction (NCEP, respectivamente. Entre maio de 2005 e julho de 2007, 27 previsões sazonais de chuva e temperatura do ar (exceto a temperatura do CPTEC/COLA, que possui 26 previsões foram avaliadas em três regiões do Brasil: Nordeste (NDE, Sudeste (SDE e Sul (SUL. As previsões do RegCM3 também foram comparadas com as climatologias das análises. De acordo com os índices estatísticos (bias, coeficiente de correlação, raiz quadrada do erro médio quadrático e coeficiente de eficiência, nas três regiões (NDE, SDE e SUL a chuva sazonal prevista pelo RegCM3 é mais próxima da observada do que a prevista pelo CPTEC/COLA. Além disto, o RegCM3 também é melhor previsor da chuva sazonal do que da média das observações nas três regiões. Para temperatura, as previsões do RegCM3 são superiores às do CPTEC/COLA nas áreas NDE e SUL, enquanto o CPTEC/COLA é superior no SDE. Finalmente, as previsões de chuva e temperatura do RegCM3 são mais próximas das observações do que a climatologia observada. Estes resultados indicam o potencial de utilização do RegCM3 para previsão sazonal, que futuramente deverá ser explorado através de previsão por conjunto.This study presents an assessment of seasonal forecasts from the regional climate model RegCM3 nested to the CPTEC/COLA global model. The used RegCM3 version is 60 km horizontal resolution over an area that includes large part of South America. RegCM3 and CPTEC/COLA forecasts were evaluated using the rainfall and air temperature analyses from Climate

  15. Phonological development in hearing learners of a sign language: The role of sign complexity and iconicity

    NARCIS (Netherlands)

    Ortega, G.; Morgan, G.

    2015-01-01

    The present study implemented a sign-repetition task at two points in time to hearing adult learners of British Sign Language and explored how each phonological parameter, sign complexity, and iconicity affected sign production over an 11-week (22-hour) instructional period. The results show that tr

  16. Conjoining Word and Image in British Sign Language (BSL): An Exploration of Metaphorical Signs in BSL

    Science.gov (United States)

    Brennan, Mary

    2005-01-01

    The Lexicon of British Sign Language (BSL), including, and perhaps especially, the productive lexicon, is highly motivated. Many sign linguists in the last few decades have played down the role of iconicity and other types of motivation in signed language. They have suggested that because sign forms and structures conform to rules of linguistic…

  17. Forced Choice Recognition of Sign in Novice Learners of British Sign Language.

    Science.gov (United States)

    Campbell, Ruth; And Others

    1992-01-01

    Investigation of the accuracy of novice learners of British Sign Language (BSL) and sign-naive subjects in recognizing possible and impossible BSL signs and in naming signs suggests that rated iconicity and the ability to process potentially meaningful gestures, determined recognition and naming accuracy. (19 references) (Author/CB)

  18. How Do You Sign "Apartheid"? The Politics of South African Sign Language.

    Science.gov (United States)

    Penn, Claire; Reagan, Timothy

    1990-01-01

    Discusses sign language use in South Africa and the deaf as an oppressed community. The following issues are addressed: language planning and sign language, the role of sign language as the vernacular of an oppressed linguistic community, and the implications of sign language for other cultural and social issues that divide South African society.…

  19. Validation and sensitivity study for the MedCORDEX domain and the Carpathian Region using RegCM4.3

    Science.gov (United States)

    Pongracz, Rita; Pieczka, Ildiko; Andre, Karolina; Bartholy, Judit

    2015-04-01

    In the framework of the Med-CORDEX international initiative our research group is participating with the specific aim of contributing to the complex regional climate modelling database with RegCM4.3 experiments at 50 km horizontal resolution using the mosaic-type subgridding option in order to take into account subgrid processes. For this purpose, we used ERA-Interim data (1981-2010) and HadGEM2 global model outputs (1951-2005) as initial and lateral boundary conditions (ICBC) for the entire MED-44 CORDEX area covering the extended Mediterranean region of Europe. The 50-km resolution RegCM-outputs serve as an ICBC input for further downscaling using 10 km as a horizontal resolution for a smaller domain covering Central Europe with special focus on the Carpathian Region. In order to quantify the impact of the use of different parameterization schemes on regional climate model outputs, hindcast experiments are completed applying the RegCM4.3 model to the Carpathian Region and its surroundings at 10 km horizontal resolution with three different cumulus convection schemes (i.e., Kuo, Emanuel, and Grell schemes with different closure methods). Besides, sensitivity of outputs for subgrid-scale processes is also studied by activating the subgrid Biosphere-Atmosphere Transfer Scheme (BATS) model within other RegCM experiments. RegCM simulation results are sensitive to the driving data since the completed experiments with ERA-Interim and HadGEM2-driven 50-km outputs as ICBC result in different bias patterns. However, when the same driving data are used with different specific set-ups, the simulation results look quite similar. To some extent RegCM is able to reduce the errors inherited from the global datasets. Our validation results for temperature and precipitation suggest that for the Carpathian Region the overall best performance is achieved when using the mixed Grell-Emanuel scheme together with Fritsch & Chappell closure. Moreover, turning the subgrid model on

  20. The Impact of Biofuels on Climate Change from Marginal Land over East Asia using the RegCM4

    Science.gov (United States)

    Kim, J. H.

    2016-12-01

    Biofuel crop, in particular, miscanthus is a promising alternative clean energy source to fossil fuel for reducing net carbon dioxide emissions in China. However, conversion of current land use for miscanthus production is practically impossible due to intensive land use. Thus, the marginal land can be utilized as a miscanthus cropland. The impact of miscanthus crop conversion on regional climate is still unclear especially in East Asia. In this study, the ICTP Regional Climate Model Version 4.3.4 coupled with Community land model Version 3.5 including representations of carbon-nitrogen dynamics (CN) and dynamic vegetation (DV) (RegCM4.3.4-CLM3.5-CNDV) is used to investigate the impact of land use conversion of biofuel within marginal land on projected changes of regional climate over CORDEX East Asia. With boundary condition from the Era-Interim 1.5° gridded (EIN15), control and several modified experiments are conducted under different conditions of PFTs and vegetation phenology. Control run (CTL) is forced by original PFTs and LAI without any alternation. While modified experiments (double, expand) include sum of marginal land PFTs into miscanthus level, and double LAI (double) and expand LAI (expand), respectively. Differences among the experiments are compared to examine the impact of miscanthus conversion of Chinese marginal land on biogeophysical properties in land surface and consequently land-atmosphere processes over east Asia. All the modified experiments that including miscanthus land conversion represent changes of several variables such as precipitation, 2m-air temperature, ET and net radiation. The physical consistency between the variables and the impact of miscanthus land cover change within marginal land which is examined in this study will serve as one potential approach to quantify the impact of land conversion in China. Keywords: Biofuels; Miscanthus; Land use change; Regional Climate Modeling; RegCM4; East AsiaAcknowledgementsThis work was

  1. Monsoon Change in East Asia in the 21st Century: Results of RegCM3%Monsoon Change in East Asia in the 21st Century: Results of RegCM3

    Institute of Scientific and Technical Information of China (English)

    SUI Yue; LANG Xian-Mei

    2012-01-01

    The authors investigate monsoon change in East Asia in the 21st century under the Special Report on Emissions Scenarios (SRES) A1B scenario using the results of a regional climate model, RegCM3, with a high horizontal resolution. First, the authors evaluate the model's performance compared with NCEP-NCAR reanalysis data, showing that the model can reliably reproduce the basic climatology of both winter and summer monsoons over East Asia. Next, it is found that the winter monsoon in East Asia would slightly weaken in the 21st century with spatial differences. Over northern East China, anomalous southerly winds would dominate in the mid-and late-21st century because the zonal land-sea thermal contrast is expected to become smaller, due to a stronger warming trend over land than over ocean. However, the intensity of the summer monsoon in East Asia shows a statistically significant upward trend over this century because the zonal land-sea thermal contrast between East Asia and the western North Pacific would become larger, which, in turn, would lead to larger sea level pressure gradients throughout East Asia and extending to the adjacent ocean.

  2. Comprehension of safety signs for construction workers: comparison of existing and newly designed signs.

    Science.gov (United States)

    Arphorn, Sara; Augsornpeug, Naiphaporn; Srisorrachatr, Suwat; Pruktharathikul, Vichai

    2003-12-01

    The comprehension of safety signs for construction workers was compared among existing and improved designs. Safety signs considered were existing signs, existing signs improved by adding text, existing signs improved by adding/changing pictorials, and existing signs improved by adding/changing pictorials and text. Three hundred and eighty-four construction workers were randomized for assignments into four groups. They were working on nine constructions work sites randomly selected from work sites located in Bangkok, Thailand. The number of workers in each work site was calculated for the proportion of the sample size and then they were randomized so that equal numbers of workers were included in the four groups. The four types of safety signs and an interview form were used to test their comprehension of safety signs. For data analysis, percentages, means, standard deviations, the chi-square test, the one-way ANOVA and LSD tests were applied. The results showed that the mean comprehension scores of the existing signs improved by adding text, the existing signs improved by adding/changing pictorials, and the existing signs improved by adding/changing pictorials and text were significantly higher than those of the existing signs. In addition, the mean comprehension scores of the existing signs improved by adding text and the existing signs improved by adding/changing pictorials and text were significantly higher than those of the existing signs improved by adding/changing pictorials. The highest mean comprehension score of safety signs for the construction workers was found in the existing signs improved by adding/changing pictorials and text. These results indicated that for construction workers, the comprehension of safety signs with pictorials and explanatory text was better than that of the existing signs.

  3. Uma proposta de dicionário de regência verbal português-espanhol para aprendizes brasileiros de espanhol

    OpenAIRE

    Aline Noimann

    2015-01-01

    Esta tese apresenta as bases para a elaboração de um protótipo de dicionário de regência verbal para alunos brasileiros estudantes de Espanhol como Língua Estrangeira e se insere na área de Estudos da Linguagem, mais especificamente na linha de pesquisa Lexicografia, Terminologia e Tradução: relações textuais. O objetivo geral desta tese é o de estabelecer os princípios e o protótipo para a elaboração de um dicionário de regência verbal Português-Espanhol para alunos brasileiros estudantes de...

  4. Effects of Cropland Cover Changes on Regional Climate over Western China Based on Simulations with RegCM3

    Institute of Scientific and Technical Information of China (English)

    SHI Xue-Li; HE Hui-Juan; REN Hong-Chang

    2013-01-01

    The impacts of land cover changes on regional climate in Shaan-Gan-Ning (SGN) in western China were simulated with RegCM3. Sensitivity experiments were conducted by replacing crop grids with different new land cover types in the key area of SGN, where the returning cropland to tree/grass project has been carried out since 1999. The modified new land cover types include desert, forest, shrub and grass. They represent degraded, improved, and maintained vegetation cover with natural canopy in the key area. Results from three individual case studies show that the land cover change causes changes in temperature and terrestrial water variables especially within the key area, while changes in precipitation are found for a larger area. The strongest changes appear where the cropland is degraded to bare soil, leading to increasing temperature and decreases in rainfall, evaporation and soil water. Opposite changes occur when cropland changed into forests, especially with strong increases in soil water. When cropland changed to grass and shrub land, the climatic changes are closer to those with forest cover. This shows the importance of improving and maintaining the vegetation in SGN for the ecosystem and regional climate.

  5. Spatial and Temporal Analysis of Projected Solar Irradiance Change over Turkey by Using the RegCM4.3

    Science.gov (United States)

    Ozturk, Tugba; Tufan Turp, M.; An, Nazan; Türkeş, Murat; Kurnaz, M. Levent

    2014-05-01

    In this research, we aim to make an alternative contribution to the studies about the prediction of solar power potential. As is well known, the largest contribution to the current climate change comes from the energy sector. In order to cope with global climate change, we have to reduce our greenhouse gas emissions mainly in the fossil fuel-based energy sector. Therefore, we need to place great emphasis on renewable energy resources such as wind and solar. Turkey is one of those countries, which have huge solar power potential depending on its geographical location. In this study, projected future changes for the periods of 2040 - 2070 and 2070 - 2100 in the net downward shortwave flux over Turkey with respect to the reference period (1970 - 2000) were investigated. Regional Climate Model (RegCM4.3) of ICTP (International Centre for Theoretical Physics) was used for the simulations of future and reference climate conditions. The HadGEM2 global climate model (Hadley Global Environment Model 2), which is developed by the Met Office Hadley Centre, was dynamically downscaled based on RCP4.5 and RCP8.5 emission scenarios for Turkey. This work has been supported by Bogazici University BAP under project number 7362. One of the authors (MLK) was partially supported by Mercator-IPC Fellowship Program.

  6. The performance of RegCM4 over the Central America and Caribbean region using different cumulus parameterizations

    Science.gov (United States)

    Martínez-Castro, Daniel; Vichot-Llano, Alejandro; Bezanilla-Morlot, Arnoldo; Centella-Artola, Abel; Campbell, Jayaka; Giorgi, Filippo; Viloria-Holguin, Cecilia C.

    2017-09-01

    A sensitivity study of the performance of the RegCM4 regional climate model driven by the ERA Interim reanalysis is conducted for the Central America and Caribbean region. A set of numerical experiments are completed using four configurations of the model, with a horizontal grid spacing of 25 km for a period of 6 years (1998-2003), using three of the convective parameterization schemes implemented in the model, the Emanuel scheme, the Grell over land-Emanuel over ocean scheme and two configurations of the Tiedtke scheme. The objective of the study is to investigate the ability of each configuration to reproduce different characteristics of the temperature, circulation and precipitation fields for the dry and rainy seasons. All schemes simulate the general temperature and precipitation patterns over land reasonably well, with relatively high correlations compared to observation datasets, though in specific regions there are positive or negative biases, greater in the rainy season. We also focus on some circulation features relevant for the region, such as the Caribbean low level jet and sea breeze circulations over islands, which are simulated by the model with varied performance across the different configurations. We find that no model configuration assessed is best performing for all the analysis criteria selected, but the Tiedtke configurations, which include the capability of tuning in particular the exchanges between cloud and environment air, provide the most balanced range of biases across variables, with no outstanding systematic bias emerging.

  7. A tour in sign language

    CERN Multimedia

    François Briard

    2016-01-01

    In early May, CERN welcomed a group of deaf children for a tour of Microcosm and a Fun with Physics demonstration.   On 4 May, around ten children from the Centre pour enfants sourds de Montbrillant (Montbrillant Centre for Deaf Children), a public school funded by the Office médico-pédagogique du canton de Genève, took a guided tour of the Microcosm exhibition and were treated to a Fun with Physics demonstration. The tour guides’ explanations were interpreted into sign language in real time by a professional interpreter who accompanied the children, and the pace and content were adapted to maximise the interaction with the children. This visit demonstrates CERN’s commitment to remaining as widely accessible as possible. To this end, most of CERN’s visit sites offer reduced-mobility access. In the past few months, CERN has also welcomed children suffering from xeroderma pigmentosum (a genetic disorder causing extreme sensiti...

  8. INERTIA SETS OF SYMMETRIC SIGN PATTERN MATRICES

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    A sign pattern matrix is a matrixwhose entries are from the set {+ ,- ,0}. The symmetric sign pattern matrices that require unique inertia have recently been characterized. The purpose of this paper is to more generally investigate the inertia sets of symmetric sign pattern matrices. In particular, nonnegative fri-diagonal sign patterns and the square sign pattern with all + entries are examined. An algorithm is given for generating nonnegative real symmetric Toeplitz matrices with zero diagonal of orders n≥3 which have exactly two negative eigenvalues. The inertia set of the square pattern with all + off-diagonal entries and zero diagonal entries is then analyzed. The types of inertias which can be in the inertia set of any sign pattern are also obtained in the paper. Specifically, certain compatibility and consecutiveness properties are established.

  9. Epidemic spreading on evolving signed networks

    CERN Document Server

    Saeedian, M; Jafari, G R; Kertesz, J

    2016-01-01

    Most studies of disease spreading consider the underlying social network as obtained without the contagion, though epidemic influences peoples willingness to contact others: A friendly contact may be turned to unfriendly to avoid infection. We study the susceptible-infected (SI) disease spreading model on signed networks, in which each edge is associated with a positive or negative sign representing the friendly or unfriendly relation between its end nodes. In a signed network, according to Heiders theory, edge signs evolve such that finally a state of structural balance is achieved, corresponding to no frustration in physics terms. However, the danger of infection affects the evolution of its edge signs. To describe the coupled problem of the sign evolution and disease spreading, we generalize the notion of structural balance by taking into account the state of the nodes. We introduce an energy function and carry out Monte-Carlo simulations on complete networks to test the energy landscape, where we find loc...

  10. RegTransBase--a database of regulatory sequences and interactions based on literature: a resource for investigating transcriptional regulation in prokaryotes.

    Science.gov (United States)

    Cipriano, Michael J; Novichkov, Pavel N; Kazakov, Alexey E; Rodionov, Dmitry A; Arkin, Adam P; Gelfand, Mikhail S; Dubchak, Inna

    2013-04-02

    Due to the constantly growing number of sequenced microbial genomes, comparative genomics has been playing a major role in the investigation of regulatory interactions in bacteria. Regulon inference mostly remains a field of semi-manual examination since absence of a knowledgebase and informatics platform for automated and systematic investigation restricts opportunities for computational prediction. Additionally, confirming computationally inferred regulons by experimental data is critically important. RegTransBase is an open-access platform with a user-friendly web interface publicly available at http://regtransbase.lbl.gov. It consists of two databases - a manually collected hierarchical regulatory interactions database based on more than 7000 scientific papers which can serve as a knowledgebase for verification of predictions, and a large set of curated by experts transcription factor binding sites used in regulon inference by a variety of tools. RegTransBase captures the knowledge from published scientific literature using controlled vocabularies and contains various types of experimental data, such as: the activation or repression of transcription by an identified direct regulator; determination of the transcriptional regulatory function of a protein (or RNA) directly binding to DNA or RNA; mapping of binding sites for a regulatory protein; characterization of regulatory mutations. Analysis of the data collected from literature resulted in the creation of Putative Regulons from Experimental Data that are also available in RegTransBase. RegTransBase is a powerful user-friendly platform for the investigation of regulation in prokaryotes. It uses a collection of validated regulatory sequences that can be easily extracted and used to infer regulatory interactions by comparative genomics techniques thus assisting researchers in the interpretation of transcriptional regulation data.

  11. Co-optimization of RegC and TWINSCAN corrections to improve the intra-field on-product overlay performance

    Science.gov (United States)

    Gorhad, Kujan; Sharoni, Ofir; Dmitriev, Vladimir; Cohen, Avi; van Haren, Richard; Roelofs, Christian; Cekli, Hakki Ergun; Gallagher, Emily; Leray, Philippe; Beyer, Dirk; Trautzsch, Thomas; Steinert, Steffen

    2016-03-01

    Improving wafer On Product Overlay (OPO) is becoming a major challenge in lithography, especially for multipatterning techniques like N-repetitive Litho-Etch steps (LEN, N >= 2). When using different scanner settings and litho processes between inter-layer overlays, intra-field overlay control becomes more complicated. In addition to the Image Placement Error (IPE) contribution, the TWINSCANTM lens fingerprint in combination with the exposure settings is playing a significant role as well. Furthermore the scanner needs to deal with dynamic fingerprints caused by for instance lens and/or reticle heating. This paper will demonstrate the complementary RegC® and TWINSCANTM solution for improving the OPO by cooptimizing the correction capabilities of the individual tools, respectively. As a consequence, the systematic intra-field fingerprints can be decreased along with the overlay (OVL) error at wafer level. Furthermore, the application could be utilized for extending some of the scanner actuators ranges by inducing a pre-determined signatures. These solutions perfectly fit into the ASML Litho InSight (LIS) product in which feedforward and feedback corrections based on YieldStar overlay and other measurements are used to improve the OPO. While the TWINSCANTM scanner corrects for global distortions (up to third order) - scanner Correctable Errors ( CE), the RegC® application can correct for the None Correctable Errors (NCE) by making the high frequency NCE into a CE with low frequency nature. The RegC® induces predictable deformation elements inside the quartz (Qz) material of the reticle, and by doing so it can induce a desired pre-defined signature into the reticle. The deformation introduced by the RegC® is optimized for the actual wafer print taking into account the scale and ortho compensation by the scanner, to correct for the systematic fingerprints and the wafer overlay. These two applications might be very powerful and could contribute to achieve a better

  12. Aphasia in a user of British Sign Language: Dissociation between sign and gesture.

    Science.gov (United States)

    Marshall, Jane; Atkinson, Jo; Smulovitch, Elaine; Thacker, Alice; Woll, Bencie

    2004-07-01

    This paper reports a single case investigation of "Charles", a Deaf man with sign language aphasia following a left CVA. Anomia, or a deficit in sign retrieval, was a prominent feature of his aphasia, and this showed many of the well-documented characteristics of speech anomia. For example, sign retrieval was sensitive to familiarity, it could be cued, and there were both semantic and phonological errors. Like a previous case in the literature (Corina, Poizner, Bellugi, Feinberg, Dowd, & O'Grady-Batch, 1992), Charles demonstrated a striking dissociation between sign and gesture, since his gesture production was relatively intact. This dissociation was impervious to the iconicity of signs. So, Charles' sign production showed no effect of iconicity, and gesture production was superior to sign production even when the forms of the signs and gestures were similar. The implications of these findings for models of sign and gesture production are discussed.

  13. CT "halo sign" in pulmonary tuberculoma.

    Science.gov (United States)

    Gaeta, M; Volta, S; Stroscio, S; Romeo, P; Pandolfo, I

    1992-01-01

    The CT halo sign has been described as the CT finding of a low-attenuation zone surrounding a pulmonary nodule. It is an early clue to the diagnosis of invasive pulmonary aspergillosis. We describe a case of CT halo sign associated with a pulmonary tuberculoma. Therefore, we think that a diagnosis other than invasive pulmonary aspergillosis should be considered in the presence of the CT halo sign in immunocompetent patients.

  14. An electronic dictionary of Danish Sign Language

    DEFF Research Database (Denmark)

    Kristoffersen, Jette Hedegaard; Troelsgård, Thomas

    2008-01-01

    Compiling sign language dictionaries has in the last 15 years changed from most often being simply collecting and presenting signs for a given gloss in the surrounding vocal language to being a complicated lexicographic task including all parts of linguistic analysis, i.e. phonology, phonetics, m......, morphology, syntax and semantics. In this presentation we will give a short overview of the Danish Sign Language dictionary project. We will further focus on lemma selection and some of the problems connected with lemmatisation....

  15. An electronic dictionary of Danish Sign Language

    DEFF Research Database (Denmark)

    Kristoffersen, Jette Hedegaard; Troelsgård, Thomas

    2008-01-01

    Compiling sign language dictionaries has in the last 15 years changed from most often being simply collecting and presenting signs for a given gloss in the surrounding vocal language to being a complicated lexicographic task including all parts of linguistic analysis, i.e. phonology, phonetics......, morphology, syntax and semantics. In this presentation we will give a short overview of the Danish Sign Language dictionary project. We will further focus on lemma selection and some of the problems connected with lemmatisation....

  16. Anti-tumor effects of proteoglycan from Phellinus linteus by immunomodulating and inhibiting Reg IV/EGFR/Akt signaling pathway in colorectal carcinoma.

    Science.gov (United States)

    Li, You-Gui; Ji, Dong-Feng; Zhong, Shi; Zhu, Jian-Xun; Chen, Shi; Hu, Gui-Yan

    2011-04-01

    Proteoglycan (P1) purified from Phellinus linteus has been reported to have anti-disease activities. The objectives of our research were to determine the anti-tumor effect and possible mechanisms of P1 on human cancer cells. Cell inhibition assay showed that P1 has an antiproliferative effect on HepG2, HT-29, NCI-H 460 and MCF-7 human colon cancer cells, especially it was very effective in inhibiting HT-29 cells. When HT-29-bearing mice were treated with P1(100mg/kg), there was relative increase in spleen and thymus weights, the plasmatic pIgR and IgA levels were significantly increased, also there was a notable decrease in plasmatic PGE2, Reg IV, EGFR and Akt concentrations measured by ELISA. RT-PCR analysis suggested that P1-induced HT-29 apoptosis appeared to be associated with a decrease in the levels of expression of Reg IV and EGFR. These results suggest that P1 might have two potential roles in treating cancer; it acts as an immunopotentiator partly through protecting T cells from escaping PGE2 attack and enhancing the mucosal IgA response, and as a direct inhibitor by disrupting the Reg IV/EGFR/Akt signaling pathway.

  17. Numerical framework and performance of the new multiple-phase cloud microphysics scheme in RegCM4.5: precipitation, cloud microphysics, and cloud radiative effects

    Science.gov (United States)

    Nogherotto, Rita; Tompkins, Adrian Mark; Giuliani, Graziano; Coppola, Erika; Giorgi, Filippo

    2016-07-01

    We implement and evaluate a new parameterization scheme for stratiform cloud microphysics and precipitation within regional climate model RegCM4. This new parameterization is based on a multiple-phase one-moment cloud microphysics scheme built upon the implicit numerical framework recently developed and implemented in the ECMWF operational forecasting model. The parameterization solves five prognostic equations for water vapour, cloud liquid water, rain, cloud ice, and snow mixing ratios. Compared to the pre-existing scheme, it allows a proper treatment of mixed-phase clouds and a more physically realistic representation of cloud microphysics and precipitation. Various fields from a 10-year long integration of RegCM4 run in tropical band mode with the new scheme are compared with their counterparts using the previous cloud scheme and are evaluated against satellite observations. In addition, an assessment using the Cloud Feedback Model Intercomparison Project (CFMIP) Observational Simulator Package (COSP) for a 1-year sub-period provides additional information for evaluating the cloud optical properties against satellite data. The new microphysics parameterization yields an improved simulation of cloud fields, and in particular it removes the overestimation of upper level cloud characteristics of the previous scheme, increasing the agreement with observations and leading to an amelioration of a long-standing problem in the RegCM system. The vertical cloud profile produced by the new scheme leads to a considerably improvement of the representation of the longwave and shortwave components of the cloud radiative forcing.

  18. Impact of resolution on regional climate modeling in the source region of Yellow River with complex terrain using RegCM3

    Science.gov (United States)

    Hui, Pinhong; Tang, Jianping; Wang, Shuyu; Wu, Jian; Niu, Xiaorui; Kang, Yue

    2016-07-01

    This paper presents results from a 20-year (1990-2009) simulation by RegCM3 with both 45- and 15-km horizontal resolutions. The research focuses on the source region of Yellow River and its surrounding area, which is located on the northeast edge of the Tibetan Plateau with its very complex topography. Driven by the ECMWF ERA-interim reanalysis data, RegCM3 displays reasonable ability to reproduce the spatial patterns, annual cycles, and the interannual variabilities of regional surface climate, though the model shows wet and cold bias. The model's performance is more close to observation for the source region of Yellow River than the other part of the analysis region, and the application of high resolution of 15 km demonstrates better skill with less bias for mean climate and larger correlation coefficients for interannual variability at most stations. However, the high-resolution simulation shows little advantage for reproducing the variations of precipitation and surface air temperature with altitude. The RegCM3 model also generally reproduces the probability distribution functions (PDFs) of surface climate and, consequently, the occurrence of climatic extremes and extreme indices. The simulation with high resolution again proves to be more reliable to generate climatic extremes over complex terrain of the source region of the Yellow River, related to its better representation of complex terrain and local processes.

  19. Assessment of RegCM4 simulated inter-annual variability and daily-scale statistics of temperature and precipitation over Mexico

    Science.gov (United States)

    Fuentes-Franco, Ramón; Coppola, Erika; Giorgi, Filippo; Graef, Federico; Pavia, Edgar G.

    2014-02-01

    The skill of a regional climate model (RegCM4) in capturing the mean patterns, interannual variability and extreme statistics of daily-scale temperature and precipitation events over Mexico is assessed through a comparison of observations and a 27-year long simulation driven by reanalyses of observations covering the Central America CORDEX domain. The analysis also includes the simulation of tropical cyclones. It is found that RegCM4 reproduces adequately the mean spatial patterns of seasonal precipitation and temperature, along with the associated interannual variability characteristics. The main model bias is an overestimation of precipitation in mountainous regions. The 5 and 95 percentiles of daily temperature, as well as the maximum dry spell length are realistically simulated. The simulated distribution of precipitation events as well as the 95 percentile of precipitation shows a wet bias in topographically complex regions. Based on a simple detection method, the model produces realistic tropical cyclone distributions even at its relatively coarse resolution (dx = 50 km), although the number of cyclone days is underestimated over the Pacific and somewhat overestimated over the Atlantic and Caribbean basins. Overall, it is assessed that the performance of RegCM4 over Mexico is of sufficient quality to study not only mean precipitation and temperature patterns, but also higher order climate statistics.

  20. Establishing the motivations of patients with dementia and cognitive impairment and their carers in joining a dementia research register (DemReg).

    Science.gov (United States)

    Avent, Cerian; Curry, Lisa; Gregory, Sarah; Marquardt, Sonia; Pae, Lauren; Wilson, Danielle; Ritchie, Karen; Ritchie, Craig W

    2013-06-01

    Connecting willing patients with dementia to suitable clinical research studies has been historically challenging. The United Kingdom Dementia and Neurodegenerative Research Network (DeNDRoN) was established to link patients into high-quality studies. One component is DemReg, a register of dementia patients and their carers who have agreed to be approached regarding future research studies. The limited literature highlights the predominance of altruism mediating research register participation. The objective of this study was to understand the motivations of patients and carers to participate in DemReg. There were 107 participants in the study, interviewed using a questionnaire to determine which factors were important in their decision to be on the register. The study compared the proportion of the altruistic motivations articulated with the proportion of the other answers offered. The two most important motivators for registering on DemReg were to help others (44%; p Participants were not motivated by the prospect of payment or by concern that they would be letting down their clinician if they did not register. There are currently major projects within the United Kingdom to increase the number of patients on dementia registers and to further involvement in dementia research. This study, to the best of our knowledge, is the first to assess the motivations of patients and carers for joining a dementia research register in the United Kingdom, and the findings highlight the importance of altruistic motives.

  1. 33 CFR 127.113 - Warning signs.

    Science.gov (United States)

    2010-07-01

    ...) WATERFRONT FACILITIES WATERFRONT FACILITIES HANDLING LIQUEFIED NATURAL GAS AND LIQUEFIED HAZARDOUS GAS Waterfront Facilities Handling Liquefied Natural Gas § 127.113 Warning signs. (a) The marine transfer...

  2. SIGN LANGUAGE RECOGNITION USING THINNING ALGORITHM

    Directory of Open Access Journals (Sweden)

    S. N. Omkar

    2011-08-01

    Full Text Available In the recent years many approaches have been made that uses computer vision algorithms to interpret sign language. This endeavour is yet another approach to accomplish interpretation of human hand gestures. The first step of this work is background subtraction which achieved by the Euclidean distance threshold method. Thinning algorithm is then applied to obtain a thinned image of the human hand for further analysis. The different feature points which include terminating points and curved edges are extracted for the recognition of the different signs. The input for the project is taken from video data of a human hand gesturing all the signs of the American Sign Language.

  3. Iconicity and Sign Lexical Acquisition: A Review

    Science.gov (United States)

    Ortega, Gerardo

    2017-01-01

    The study of iconicity, defined as the direct relationship between a linguistic form and its referent, has gained momentum in recent years across a wide range of disciplines. In the spoken modality, there is abundant evidence showing that iconicity is a key factor that facilitates language acquisition. However, when we look at sign languages, which excel in the prevalence of iconic structures, there is a more mixed picture, with some studies showing a positive effect and others showing a null or negative effect. In an attempt to reconcile the existing evidence the present review presents a critical overview of the literature on the acquisition of a sign language as first (L1) and second (L2) language and points at some factor that may be the source of disagreement. Regarding sign L1 acquisition, the contradicting findings may relate to iconicity being defined in a very broad sense when a more fine-grained operationalisation might reveal an effect in sign learning. Regarding sign L2 acquisition, evidence shows that there is a clear dissociation in the effect of iconicity in that it facilitates conceptual-semantic aspects of sign learning but hinders the acquisition of the exact phonological form of signs. It will be argued that when we consider the gradient nature of iconicity and that signs consist of a phonological form attached to a meaning we can discern how iconicity impacts sign learning in positive and negative ways. PMID:28824480

  4. Objects in Films: analyzing signs

    Directory of Open Access Journals (Sweden)

    GAMBARATO, Renira Rampazzo

    2009-12-01

    Full Text Available The focus of this essay is the analysis of daily objects as signs in films. Objects from everyday life acquire several functions in films: they can be solely used as scene objects or to support a particular film style. Other objects are specially chosen to translate a character’s interior state of mind or the filmmaker’s aesthetical or ethical commitment to narrative concepts. In order to understand such functions and commitments, we developed a methodology for film analysis which focuses on the objects. Object interpretation, as the starting point of film analysis, is not a new approach. For instance, French film critic André Bazin proposed that use of object interpretation in the 1950s. Similarly, German film theorist Siegfried Kracauer stated it in the 1960s. However, there is currently no existing analytical model to use when engaging in object interpretation in film. This methodology searches for the most representative objects in films which involves both quantitative and qualitative analysis; we consider the number of times each object appears in a film (quantitative analysis as well as the context of their appearance, i.e. the type of shot used and how that creates either a larger or smaller relevance and/or expressiveness (qualitative analysis. In addition to the criteria of relevance and expressiveness, we also analyze the functionality of an object by exploring details and specifying the role various objects play in films. This research was developed at Concordia University, Montreal, Canada and was supported by the Foreign Affairs and International Trade, Canada (DFAIT.

  5. What Are the Signs and Symptoms of Heart Disease?

    Science.gov (United States)

    ... Twitter. What Are the Signs and Symptoms of Heart Disease? The signs and symptoms of coronary heart disease ( ... will have signs and symptoms of the disease. Heart Disease Signs and Symptoms The illustration shows the major ...

  6. God and the World of Signs

    DEFF Research Database (Denmark)

    Kristensen, Johanne Stubbe T

    2016-01-01

    Review of Robinson, Andrew (Andrew John Nottage). God and the world of signs: Trinity, evolution, and the metaphysical semiotics of C. S. Peirce. Publisher: Leiden: Brill, 2010. ISBN: 9789004187993......Review of Robinson, Andrew (Andrew John Nottage). God and the world of signs: Trinity, evolution, and the metaphysical semiotics of C. S. Peirce. Publisher: Leiden: Brill, 2010. ISBN: 9789004187993...

  7. Mental Illness in Children: Know the Signs

    Science.gov (United States)

    ... Autism spectrum disorder: Signs and symptoms. Centers for Disease Control and Prevention. http://www.cdc.gov/ncbddd/autism/signs.html. Accessed Dec. 8, 2014. Feb. 11, 2015 Original article: http://www.mayoclinic.org/healthy-lifestyle/childrens-health/in-depth/mental-illness-in-children/ ...

  8. 46 CFR 154.1830 - Warning sign.

    Science.gov (United States)

    2010-10-01

    ... (2) Facing outboard towards the water so that the sign may be seen from the water. (b) Except as provided in paragraph (e) of this section, each warning sign must have the following words: (1) Warning. (2) Dangerous Cargo. (3) No Visitors. (4) No Smoking. (5) No Open Lights. (c) Each letter in the words on...

  9. Sign Language and the Brain: A Review

    Science.gov (United States)

    Campbell, Ruth; MacSweeney, Mairead; Waters, Dafydd

    2008-01-01

    How are signed languages processed by the brain? This review briefly outlines some basic principles of brain structure and function and the methodological principles and techniques that have been used to investigate this question. We then summarize a number of different studies exploring brain activity associated with sign language processing…

  10. 14 CFR 406.111 - Signing documents.

    Science.gov (United States)

    2010-01-01

    ... individual's knowledge, information, and belief, the document is— (1) Consistent with these rules; (2... signed in violation of this section; (2) Strike the request for discovery or the discovery response signed in violation of this section and preclude further discovery by the party; (3) Deny the motion...

  11. Historical Development of Hong Kong Sign Language

    Science.gov (United States)

    Sze, Felix; Lo, Connie; Lo, Lisa; Chu, Kenny

    2013-01-01

    This article traces the origins of Hong Kong Sign Language (hereafter HKSL) and its subsequent development in relation to the establishment of Deaf education in Hong Kong after World War II. We begin with a detailed description of the history of Deaf education with a particular focus on the role of sign language in such development. We then…

  12. Research Ethics in Sign Language Communities

    Science.gov (United States)

    Harris, Raychelle; Holmes, Heidi M.; Mertens, Donna M.

    2009-01-01

    Codes of ethics exist for most professional associations whose members do research on, for, or with sign language communities. However, these ethical codes are silent regarding the need to frame research ethics from a cultural standpoint, an issue of particular salience for sign language communities. Scholars who write from the perspective of…

  13. Phonological Awareness for American Sign Language

    Science.gov (United States)

    Corina, David P.; Hafer, Sarah; Welch, Kearnan

    2014-01-01

    This paper examines the concept of phonological awareness (PA) as it relates to the processing of American Sign Language (ASL). We present data from a recently developed test of PA for ASL and examine whether sign language experience impacts the use of metalinguistic routines necessary for completion of our task. Our data show that deaf signers…

  14. China and Chile Signing Free Trade Agreement

    Institute of Scientific and Technical Information of China (English)

    Shen; Danyang

    2005-01-01

      Mr. Bo Xilai, Minister of Commerce of China, and Mr.Walker, Foreign Minister of Chile, signed the China-Chile FTA on behalf of their respective government on November 18, 2005. Chinese President Hu Jintao and Chile President Lagos attended the signing ceremony, according to a press release on the website of Network Center of MOFCOM.……

  15. China and Chile Signing Free Trade Agreement

    Institute of Scientific and Technical Information of China (English)

    Shen Danyang

    2005-01-01

    @@ Mr. Bo Xilai, Minister of Commerce of China, and Mr.Walker, Foreign Minister of Chile, signed the China-Chile FTA on behalf of their respective government on November 18, 2005. Chinese President Hu Jintao and Chile President Lagos attended the signing ceremony, according to a press release on the website of Network Center of MOFCOM.

  16. The Functional Use of a Mathematical Sign

    Science.gov (United States)

    Berger, Margot

    2004-01-01

    The question of how a mathematics student at university-level makes sense of a new mathematical sign, presented to her or him in the form of a definition, is a fundamental problem in mathematics education. Using an analogy with Vygotsky's theory (1986, 1994) of how a child learns a new word, I argue that a learner uses a new mathematical sign both…

  17. Life-sign detection with FMCW radar

    NARCIS (Netherlands)

    Jong, A.J. de; Anitori, L.

    2008-01-01

    In this paper we present some preliminary results on life-sign detection using FMCW radars. Several persons were observed from different aspects with carrier frequencies between 2.4 GHz and 24 GHz. In most cases, reliable life-sign measurements could be done, although we found a considerable influen

  18. Signs and Symptoms of Congenital Heart Defects

    Science.gov (United States)

    ... Twitter. What Are the Signs and Symptoms of Congenital Heart Defects? Many congenital heart defects cause few or no signs and symptoms. A ... lips, and fingernails) Fatigue (tiredness) Poor blood circulation Congenital heart defects don't cause chest pain or other painful ...

  19. Atrophic vaginitis: signs, symptoms, and better outcomes.

    Science.gov (United States)

    Reimer, Annabelle; Johnson, Laura

    2011-01-01

    Atrophic vaginitis is a common finding in women with low estrogen states. Many women believe their symptoms are expected signs of aging. NPs can provide therapeutic options to improve vaginal health and quality of life. This article reviews physiology, clinical manifestations, signs, symptoms, and treatment methods for atrophic vaginitis.

  20. Numeral Variation in New Zealand Sign Language

    Science.gov (United States)

    McKee, David; McKee, Rachel; Major, George

    2011-01-01

    Lexical variation abounds in New Zealand Sign Language (NZSL) and is commonly associated with the introduction of the Australasian Signed English lexicon into Deaf education in 1979, before NZSL was acknowledged as a language. Evidence from dictionaries of NZSL collated between 1986 and 1997 reveal many coexisting variants for the numbers from one…

  1. Tritium in Exit Signs | RadTown USA | US EPA

    Science.gov (United States)

    2017-08-07

    Many exit signs contain tritium to light the sign without batteries or electricity. Using tritium in exit signs allows the sign to remain lit if the power goes out. Tritium is most dangerous when it is inhaled or swallowed. Never tamper with a tritium exit sign. If a tritium exit sign is broken, leave the area immediately and notify the building maintenance staff.

  2. Signs, dispositions, and semiotic scaffolding.

    Science.gov (United States)

    Fernández, Eliseo

    2015-12-01

    In theoretical work we distinguish living beings from inanimate objects on the basis of some paramount attributes, such as agency and autonomy. These abstract features are not directly accessible to our scrutiny, but we surmise their nature through observation of the purpose-oriented behavior of organisms. I intend to show that organismal purposefulness springs from the intrinsic, constitutive kind of finality that is the hallmark of all semiotic transactions. To this aim I develop a dispositionalist account of organismal causation based on a distinction between two kinds of causal dispositions: fixed (efficient) dispositions and traveling dispositions. Fixed dispositions are rigidly attached to physical structures and processes; these are the dispositions regularly invoked in current discussions of causal explanation. Traveling dispositions are able to move freely from one location to another by becoming embodied into suitable supporting media. I introduce these notions to articulate a view of semiosis I deem best suited to the life sciences, and contend that sign tokens are vehicles of traveling dispositions. This account places the origin of purposive behavior at the interaction of physical and semiotic causation. To properly motivate the discussion I briefly review some recent developments in the philosophy of science concerning various forms of causation invoked by scientists across disciplines to frame explanations and make predictions. The ensuing discussion gives particular prominence to mechanistic (as distinct from mechanicist) explanatory accounts of biological phenomena. This review is followed by a brief characterization of a "nomological machine," a comprehensive schema introduced and developed by Nancy Cartwright with the goal of explaining causal mechanisms in a general setting. By capitalizing on this model's heuristic virtues I seek to formulate a compelling view of the interactions between physical and semiotic causation at play in semiotic

  3. Arabic Alphabet and Numbers Sign Language Recognition

    Directory of Open Access Journals (Sweden)

    Mahmoud Zaki Abdo

    2015-11-01

    Full Text Available This paper introduces an Arabic Alphabet and Numbers Sign Language Recognition (ArANSLR. It facilitates the communication between the deaf and normal people by recognizing the alphabet and numbers signs of Arabic sign language to text or speech. To achieve this target, the system able to visually recognize gestures from hand image input. The proposed algorithm uses hand geometry and the different shape of a hand in each sign for classifying letters shape by using Hidden Markov Model (HMM. Experiments on real-world datasets showed that the proposed algorithm for Arabic alphabet and numbers sign language recognition is suitability and reliability compared with other competitive algorithms. The experiment results show that the increasing of the gesture recognition rate depends on the increasing of the number of zones by dividing the rectangle surrounding the hand.

  4. Eigen-Gradients for Traffic Sign Recognition

    Directory of Open Access Journals (Sweden)

    Sheila Esmeralda Gonzalez-Reyna

    2013-01-01

    Full Text Available Traffic sign detection and recognition systems include a variety of applications like autonomous driving, road sign inventory, and driver support systems. Machine learning algorithms provide useful tools for traffic sign identification tasks. However, classification algorithms depend on the preprocessing stage to obtain high accuracy rates. This paper proposes a road sign characterization method based on oriented gradient maps and the Karhunen-Loeve transform in order to improve classification performance. Dimensionality reduction may be important for portable applications on resource constrained devices like FPGAs; therefore, our approach focuses on achieving a good classification accuracy by using a reduced amount of attributes compared to some state-of-the-art methods. The proposed method was tested using German Traffic Sign Recognition Benchmark, reaching a dimensionality reduction of 99.3% and a classification accuracy of 95.9% with a Multi-Layer Perceptron.

  5. Road Signs for UV-Completion

    CERN Document Server

    Dvali, Gia; Gomez, Cesar

    2012-01-01

    We confront the concepts of Wilsonian UV-completion versus self-completion by Classicalization in theories with derivatively-coupled scalars. We observe that the information about the UV-completion road is encoded in the sign of the derivative terms. We note that the sign of the derivative couplings for which there is no consistent Wilsonian UV-completion is the one that allows for consistent classicalons. This is an indication that for such a sign the vertex must be treated as fundamental and the theory self-protects against potential inconsistencies, such as superluminality, via self-completion by classicalization. Applying this reasoning to the UV-completion of the Standard Model, we see that the information about the Higgs versus classicalization is encoded in the sign of the scattering amplitude of longitudinal W-bosons. Negative sign excludes Higgs or any other weakly-coupled Wilsonian physics.

  6. Sharing Vital Signs between mobile phone applications.

    Science.gov (United States)

    Karlen, Walter; Dumont, Guy A; Scheffer, Cornie

    2014-01-01

    We propose a communication library, ShareVitalSigns, for the standardized exchange of vital sign information between health applications running on mobile platforms. The library allows an application to request one or multiple vital signs from independent measurement applications on the Android OS. Compatible measurement applications are automatically detected and can be launched from within the requesting application, simplifying the work flow for the user and reducing typing errors. Data is shared between applications using intents, a passive data structure available on Android OS. The library is accompanied by a test application which serves as a demonstrator. The secure exchange of vital sign information using a standardized library like ShareVitalSigns will facilitate the integration of measurement applications into diagnostic and other high level health monitoring applications and reduce errors due to manual entry of information.

  7. Building an Assessment Use Argument for sign language: the BSL Nonsense Sign Repetition Test

    OpenAIRE

    Mann, W.; Marshall, C. R.

    2010-01-01

    In this article, we adapt a concept designed to structure language testing more effectively, the Assessment Use Argument (AUA), as a framework for the development and/or use of sign language assessments for deaf children who are taught in a sign bilingual education setting. By drawing on data from a recent investigation of deaf children's nonsense sign repetition skills in British Sign Language, we demonstrate the steps of implementing the AUA in practical test design, development and use. Th...

  8. Simulation of bulk aerosol direct radiative effects and its climatic feedbacks in South Africa using RegCM4

    Science.gov (United States)

    Tesfaye, M.; Botai, J.; Sivakumar, V.; Mengistu Tsidu, G.; Rautenbach, C. J. deW.; Moja, Shadung J.

    2016-05-01

    In this study, 12 year runs of the Regional Climate Model (RegCM4) have been used to analyze the bulk aerosol radiative effects and its climatic feedbacks in South Africa. Due to the geographical locations where the aerosol potential source regions are situated and the regional dynamics, the South African aerosol spatial-distribution has a unique feature. Across the west and southwest areas, desert dust particles are dominant. However, sulfate and carbonaceous aerosols are primarily distributed over the east and northern regions of the country. Analysis of the Radiative Effects (RE) shows that in South Africa the bulk aerosols play a role in reducing the net radiation absorbed by the surface via enhancing the net radiative heating in the atmosphere. Hence, across all seasons, the bulk aerosol-radiation-climate interaction induced statistically significant positive feedback on the net atmospheric heating rate. Over the western and central parts of South Africa, the overall radiative feedbacks of bulk aerosol predominantly induces statistically significant Cloud Cover (CC) enhancements. Whereas, over the east and southeast coastal areas, it induces minimum reductions in CC. The CC enhancement and RE of aerosols jointly induce radiative cooling at the surface which in turn results in the reduction of Surface Temperature (ST: up to -1 K) and Surface Sensible Heat Flux (SSHF: up to -24 W/m2). The ST and SSHF decreases cause a weakening of the convectively driven turbulences and surface buoyancy fluxes which lead to the reduction of the boundary layer height, surface pressure enhancement and dynamical changes. Throughout the year, the maximum values of direct and semi-direct effects of bulk aerosol were found in areas of South Africa which are dominated by desert dust particles. This signals the need for a strategic regional plan on how to reduce the dust production and monitoring of the dust dispersion as well as it initiate the need of further research on different

  9. Conflictos por el agua y regímenes políticos: Argentina y México

    Directory of Open Access Journals (Sweden)

    Karina Beatriz Kloster

    2015-03-01

    Full Text Available En algunas regiones de América Latina comienzan a aparecer, frente al agotamiento del modelo neoliberal, gobiernos con una retórica centrada en la inclusión social, en la reparación de los daños provocados por la doble transición (económica y política y en la promesa de fortalecimiento y democratización de los espacios públicos-políticos.  Por otra lado, países como México, Perú, Colombia, Chile, han sostenido mayor continuidad con el modelo neoliberal y la retórica sigue siendo conservadora y centrada en la libertad de los mercados y la inserción internacional. A pesar de estas diversas alternativas gestadas en los distintos gobiernos latinoamericanos, queda la duda sobre si existe una diferencia en torno a las formas en que se relacionan estos modelos con la naturaleza ya que la conflictividad social en torno al agua en la región (independientemente del modelo escogido no ha dejado de ser un problema de primer orden, aun cuando se diversifiquen sus fuentes y formas de manifestación (sujetos, demandas, condiciones de emergencia, etc.. Es por esto que el objetivo del presente trabajo es comparar cómo se han dado las luchas por el agua en los distintos territorios de Argentina y México para comenzar a conocer la relación entre el uso del agua como territorio político de dominación en los distintos regímenes políticos.  Para ello se han realizado dos bases de datos hemerográficas comparativas, de conflictos por el agua durante el año 2010, para Argentina y México.

  10. Performance of ICTP's RegCM4 in Simulating the Rainfall Characteristics over the CORDEX-SEA Domain

    Science.gov (United States)

    Neng Liew, Ju; Tangang, Fredolin; Tieh Ngai, Sheau; Chung, Jing Xiang; Narisma, Gemma; Cruz, Faye Abigail; Phan Tan, Van; Thanh, Ngo-Duc; Santisirisomboon, Jerasron; Milindalekha, Jaruthat; Singhruck, Patama; Gunawan, Dodo; Satyaningsih, Ratna; Aldrian, Edvin

    2015-04-01

    The performance of the RegCM4 in simulating rainfall variations over the Southeast Asia regions was examined. Different combinations of six deep convective parameterization schemes, namely i) Grell scheme with Arakawa-Schubert closure assumption, ii) Grell scheme with Fritch-Chappel closure assumption, iii) Emanuel MIT scheme, iv) mixed scheme with Emanuel MIT scheme over the Ocean and the Grell scheme over the land, v) mixed scheme with Grell scheme over the land and Emanuel MIT scheme over the ocean and (vi) Kuo scheme, and three ocean flux treatments were tested. In order to account for uncertainties among the observation products, four different gridded rainfall products were used for comparison. The simulated climate is generally drier over the equatorial regions and slightly wetter over the mainland Indo-China compare to the observation. However, simulation with MIT cumulus scheme used over the land area consistently produces large amplitude of positive rainfall biases, although it simulates more realistic annual rainfall variations. The simulations are found less sensitive to treatment of ocean fluxes. Although the simulations produced the rainfall climatology well, all of them simulated much stronger interannual variability compare to that of the observed. Nevertheless, the time evolution of the inter-annual variations was well reproduced particularly over the eastern part of maritime continent. Over the mainland Southeast Asia (SEA), unrealistic rainfall anomalies processes were simulated. The lacking of summer season air-sea interaction results in strong oceanic forcings over the regions, leading to positive rainfall anomalies during years with warm ocean temperature anomalies. This incurs much stronger atmospheric forcings on the land surface processes compare to that of the observed. A score ranking system was designed to rank the simulations according to their performance in reproducing different aspects of rainfall characteristics. The result suggests

  11. La historia local desde la perspectiva de la sociología de los regímenes

    Directory of Open Access Journals (Sweden)

    Armando Martínez Garnica

    2009-01-01

    Full Text Available El artículo analiza la historia local a partir de la sociología de regímenes propuesta por Fred Spier y clasificada por Norbert Elias. El texto analiza los aspectos políticos , ambientales y personales en ámbitos locales. El autor expone la funcionalidad explicativa y analítica del concepto, y lo instrumentaliza en el caso de la fundación y el ámbito social de San Juan Girón (Santander, Colombia en el siglo XVII. La fundación es vista como el establecimiento de un régimen político cuyas figuras y entidades activas las representa el gobernador y el Cabildo de la ciudad en el marco de una serie de conflictos jurisdiccionales con los habitantes nativos y de localidades vecinas. El efecto de la fundación estimula un proceso de colonización en un paisaje geográfico que determina el régimen ambiental en el que se destacan colonos, hacendados, agricultores y ganaderos. Finalmente el régimen individual se traduce en la creación de redes de parentesco, que reflejan diferenciaciones y rivalidades sociales y étnicas entre grupos y personajes distinguidos de la localidad. El autor se apoya en fuentes primarias y secundarias para rendir cuenta del proceso político-administrativo de la fundación y la emergencia de personajes que constituyeron la red socio-administrativa y gestora del hecho histórico.

  12. Simulation of Indian summer monsoon onset with different parameterization convection schemes of RegCM-4.3

    Science.gov (United States)

    Bhatla, R.; Ghosh, S.; Mandal, B.; Mall, R. K.; Sharma, Kuldeep

    2016-07-01

    Simulation of Indian Summer Monsoon (ISM) onset over South Asia Coordinated Regional Climate Downscaling Experiment (CORDEX) domain in pentad composite pattern is considered for this study. The latest version of the International Center for Theoretical Physics' (ICTP's) Regional Climate Model version 4.3 (RegCM-4.3) is used for the simulation of a pentad composite onset for three time period: Pre-onset, Onset and Post-onset periods of ISM. Each pentad composite is average of five consecutive days. 10 years (2001-2010) worth of pentad composites of rainfall, mean sea level pressure (MSLP), outgoing longwave radiation (OLR), wind at 850 hPa and 925 hPa levels till 7 days prior to the date of onset of monsoon and 7 days after the onset are analyzed to find out the predictive skill. Six Parameterization convection schemes (PCSs) viz. Kuo, Mix98, Mix99, Tiedtke, Emanuel and Grell are used in sensitivity experiment and estimation of their performance has been done. From the experiment, some modulation is found in the OLR field (≤ 200 Wm- 2) within the region 5°N-10°N and 70°N-75°E. Yearly analysis has shown the strength of wind at 925 hPa over the region 5°N-10°N and 70°E-80°E on pentad composite onset of ISM. Yearly analysis is conducted for finding the best fitted PCS which has provided the precursor for simulating the onset.

  13. ProRegIn: A regularity index for the selection of native-like tertiary structures of proteins

    Indian Academy of Sciences (India)

    Lipi Thukral; Sandhya R Shenoy; Kumkum Bhushan; B Jayaram

    2007-01-01

    Automated protein tertiary structure prediction from sequence information alone remains an elusive goal to computational prescriptions. Dividing the problem into three stages viz. secondary structure prediction, generation of plausible main chain loop dihedrals and side chain dihedral optimization, considerable progress has been achieved in our laboratory (http://www.scfbio-iitd.res.in/bhageerath/index.jsp) and elsewhere for proteins with less than 100 amino acids. As a part of our on-going efforts in this direction and to facilitate tertiary structure selection/rejection in containing the combinatorial explosion of trial structures for a specified amino acid sequence, we describe here a web-enabled tool ProRegIn (Protein Regularity Index) developed based on the regularity in the , Ψ dihedral angles of the amino acids that constitute loop regions. We have analysed the dihedrals in loop regions in a non-redundant dataset of 7351 proteins drawn from the Protein Data Bank and categorized them as helix-like or sheet-like (regular) or irregular. We noticed that the regularity thus defined exceeds 86% for barring glycine and 70% for Ψ for all the amino acid side chains including glycine, compelling us to reexamine the conventional view that loops are irregular regions structurally. The regularity index is presented here as a simple tool that finds its application in protein structure analysis as a discriminatory scoring function for rapid screening before the more compute intensive atomic level energy calculations could be undertaken. The tool is made freely accessible over the internet at www.scfbio-iitd.res.in/software/proregin.jsp.

  14. The First Signs of Language: Phonological Development in British Sign Language

    Science.gov (United States)

    Morgan, Gary; Barrett-Jones, Sarah; Stoneham, Helen

    2007-01-01

    A total of 1,018 signs in one deaf child's naturalistic interaction with her deaf mother, between the ages of 19 and 24 months were analyzed. This study summarizes regular modification processes in the phonology of the child sign's handshape, location, movement, and prosody. First, changes to signs were explained by the notion of phonological…

  15. Signed Language Working Memory Capacity of Signed Language Interpreters and Deaf Signers

    Science.gov (United States)

    Wang, Jihong; Napier, Jemina

    2013-01-01

    This study investigated the effects of hearing status and age of signed language acquisition on signed language working memory capacity. Professional Auslan (Australian sign language)/English interpreters (hearing native signers and hearing nonnative signers) and deaf Auslan signers (deaf native signers and deaf nonnative signers) completed an…

  16. Sign Vocabulary in Deaf Toddlers Exposed to Sign Language since Birth

    Science.gov (United States)

    Rinaldi, Pasquale; Caselli, Maria Cristina; Di Renzo, Alessio; Gulli, Tiziana; Volterra, Virginia

    2014-01-01

    Lexical comprehension and production is directly evaluated for the first time in deaf signing children below the age of 3 years. A Picture Naming Task was administered to 8 deaf signing toddlers (aged 2-3 years) who were exposed to Sign Language since birth. Results were compared with data of hearing speaking controls. In both deaf and hearing…

  17. Signs and the Process of Interpretation: Sign as an Object and as a Process

    Science.gov (United States)

    Saenz-Ludlow, Adalira

    2007-01-01

    Historically the words representation and symbol have had overlapping meanings, meanings that usually disregard the role played by the interpreter. Peirce's theory of signs accounts for these meanings and also for the role of the interpreter. His theory draws attention to the static and dynamic nature of signs. Sign interpretation can be viewed as…

  18. Sociolinguistic Variation and Change in British Sign Language Number Signs: Evidence of Leveling?

    Science.gov (United States)

    Stamp, Rose; Schembri, Adam; Fenlon, Jordan; Rentelis, Ramas

    2015-01-01

    This article presents findings from the first major study to investigate lexical variation and change in British Sign Language (BSL) number signs. As part of the BSL Corpus Project, number sign variants were elicited from 249 deaf signers from eight sites throughout the UK. Age, school location, and language background were found to be significant…

  19. The Babinski sign--a reappraisal.

    Science.gov (United States)

    Kumar, S P; Ramasubramanian, D

    2000-12-01

    In 1896, Joseph Babinski, a French neurologist, first described the best known neurologic eponym 'the Babinski sign'. This sign is characterised by dorsiflexion of the big toe and recruitment of the extensor hallucis longus muscle, on stimulating the sole of the foot. He has emphasised from the outset, the intimate relationship between this sign and the shortening movement in other leg muscles, which form the flexion synergy of the lower limb. The Babinski sign is not a new reflex, rather it is released as a result of breakdown of the harmonious integration of the flexion and extension components of the normal defence reflex mechanism, due to pyramidal tract dysfunction. A pathological Babinski sign should be clearly distinguished from upgoing toes that may not always be a part of the flexion synergy. This article reviews the Babinski sign in detail, focusing on the historical perspectives, role of pyramidal tract dysfunction and art of elicitation and interpretation. The significance of assessing this phenomenon in the entire leg, and the clinical clues that will help to dispel the myths regarding the Babinski sign, have been emphasised.

  20. The Babinski sign--a critical review.

    Science.gov (United States)

    Kumar, S P

    2003-01-01

    In 1896, Josph Babinski, a French neurologist, first described the best known neurologic eponym--"the Babinski sign". This sign is characterised by dorsiflexion of the big toe, by recruitment of the extensor hallucis longus muscle, on stimulating the sole of the foot. He himself emphasised from the outset the intimate relationship between this sign and the shortening movement in other leg muscles, which forms the flexion synergy of the lower limb. The Babinski sign is not a new reflex, rather it is released as a result of breakdown of the harmonious integration of the flexion and extension component of the normal defence reflex mechanism, due to pyramidal tract dysfunction. A pathological Babinski sign should be clearly distinguished from upgoing toes that may not always be a part of the flexion synergy. This article reviews the Babinski sign in detail, focusing on the historical perspectives, role of pyramidal tract dysfunction, art of elicitation and interpretation. The significance of assessing this phenomenon in the entire leg and the clinical clues that will help to dispel the myths regarding the Babinski sign has been emphasized.

  1. Sign variation, the Grassmannian, and total positivity

    CERN Document Server

    Karp, Steven N

    2016-01-01

    The totally nonnegative Grassmannian is the set of k-dimensional subspaces V of R^n whose nonzero Pluecker coordinates all have the same sign. Gantmakher and Krein (1950) and Schoenberg and Whitney (1951) independently showed that V is totally nonnegative iff every vector in V, when viewed as a sequence of n numbers and ignoring any zeros, changes sign at most k-1 times. We generalize this result from the totally nonnegative Grassmannian to the entire Grassmannian, showing that if V is generic (i.e. has no zero Pluecker coordinates), then the vectors in V change sign at most m times iff certain sequences of Pluecker coordinates of V change sign at most m-k+1 times. We also give an algorithm which, given a non-generic V whose vectors change sign at most m times, perturbs V into a generic subspace whose vectors also change sign at most m times. We deduce that among all V whose vectors change sign at most m times, the generic subspaces are dense. These results generalize to oriented matroids. As an application o...

  2. The Phonetics of Head and Body Movement in the Realization of American Sign Language Signs.

    Science.gov (United States)

    Tyrone, Martha E; Mauk, Claude E

    2016-01-01

    Because the primary articulators for sign languages are the hands, sign phonology and phonetics have focused mainly on them and treated other articulators as passive targets. However, there is abundant research on the role of nonmanual articulators in sign language grammar and prosody. The current study examines how hand and head/body movements are coordinated to realize phonetic targets. Kinematic data were collected from 5 deaf American Sign Language (ASL) signers to allow the analysis of movements of the hands, head and body during signing. In particular, we examine how the chin, forehead and torso move during the production of ASL signs at those three phonological locations. Our findings suggest that for signs with a lexical movement toward the head, the forehead and chin move to facilitate convergence with the hand. By comparison, the torso does not move to facilitate convergence with the hand for signs located at the torso. These results imply that the nonmanual articulators serve a phonetic as well as a grammatical or prosodic role in sign languages. Future models of sign phonetics and phonology should take into consideration the movements of the nonmanual articulators in the realization of signs. © 2016 S. Karger AG, Basel.

  3. VARIATIONS IN TACTILE SIGNING – THE CASE OF ONE-HANDED SIGNING

    Directory of Open Access Journals (Sweden)

    Johanna Mesch

    2011-01-01

    Full Text Available Tactile sign language is a variety of a national sign language. Tactile signing among persons with deafblindness also includes some minor variations. Early analyses of tactile Swedish Sign Language (e.g. Mesch 1998, 2001 show how interactants use both their hands in tactile communication in two different positions: dialogue position and monologue position. This paper examines the signing variations that partially or functionally blind signers encounter when using one hand to communicate with each other in a conversation dyad in what is one of the most advanced types of sign language communication. In tactile one-handed signing, the signer uses her right hand both for producing and receiving signs, while the addressee uses her left hand not only for receiving but also for producing signs after turn-taking, even though it is the non-dominant hand and, therefore, is not normally used to produce one-handed signs. In this study, conversation analysis was conducted on the discourse of four groups. The results show that some variations depend on the linguistic background of individuals and their everyday communication. A comparative study of a two-handed and a one-handed system is then presented, focusing on issues of simplicity, flexibility, turn-taking, and feedback. Some results showing changes in the sign structures of both communication types are also presented.

  4. The "shirt collar sign" of cervical dystonia.

    Science.gov (United States)

    Silver, Michael R; Hanfelt, John; Factor, Stewart A

    2017-05-01

    The diagnosis of cervical dystonia (CD) is clinical. We describe a physical examination observation that has been noted in CD patients. There is a tendency for their shirt collars to be shifted to one side. We validated this apparently consistent finding by having blinded evaluators rating the symmetry of the shirt collars in CD and non-cervical dystonia control subjects. A high correlation was found between the physical finding which we call "shirt collar sign" and the diagnosis. "Shirt collar sign" may be a helpful sign in diagnosing CD.

  5. How to estimate the signs' configuration in the directed signed social networks?

    Science.gov (United States)

    Guo, Long; Gao, Fujuan; Jiang, Jian

    2017-02-01

    Inspired by the ensemble theory in statistical mechanics, we introduce a reshuffling approach to empirical analyze signs' configuration in the directed signed social networks of Epinions and Slashdots. In our reshuffling approach, each negative link has the reshuffling probability prs to exchange its sign with another positive link chosen randomly. Many reshuffled networks with different signs' configuration are built under different prss. For each reshuffled network, the entropies of the self social status are calculated and the opinion formation of the majority-rule model is analyzed. We find that Souts reach their own minimum values and the order parameter |m* | reaches its maximum value in the networks of Epinions and Slashdots without the reshuffling operation. Namely, individuals share the homogeneous properties of self social status and dynamic status in the real directed signed social networks. Our present work provides some interesting tools and perspective to understand the signs' configuration in signed social networks, especially in the online affiliation networks.

  6. Generalizing everyday memory: signs and handedness.

    Science.gov (United States)

    Martin, M; Jones, G V

    1998-03-01

    Memory for frequently encountered road signs was investigated. In Experiment 1, the average level of recall of road sign features was found to be only 47%. In Experiment 2, more left-handed than right-handed people recalled that a walking figure faces right on one sign, whereas more right-handed than left-handed people recalled that a digging figure faces left on another sign. Performance thus reflected not a difference in level of mnemonic ability between left-handed and right-handed groups but instead the compatibility between group and task. In Experiment 3, participants were asked to draw any figure walking and any figure digging, with a pattern of results similar to that of Experiment 2. It is suggested that handedness effects in recall are mediated by motor imagery.

  7. Water Breaking: Understand This Sign of Labor

    Science.gov (United States)

    Healthy Lifestyle Labor and delivery, postpartum care Water breaking worries? Prepare yourself for childbirth by getting the facts about this important sign of labor. By Mayo Clinic Staff If you're ...

  8. What Are the Warning Signs of Stroke?

    Science.gov (United States)

    ... Cardiovascular Conditions What Are the Warning Signs of Stroke? Brain tissue affected by blockage Stroke is the fifth leading cause of death in ... over 55 years old have more chance of stroke, and the risk gets greater as you get ...

  9. Naine objektistab meest / Fideelia-Signe Roots

    Index Scriptorium Estoniae

    Roots, Fideelia-Signe, 1976-

    2009-01-01

    Fideelia-Signe Roots Eesti Kunstiakadeemias 2009. a. kevadsemestril enda poolt läbi viidud valikainekursusest "Kunstiteose anatoomiast mehe anatoomiani", mis lõppes näitusega "Tõuseb / ei tõuse" Eesti Tervishoiumuuseumis, avatud 31. maini

  10. Phonological "Deviance" in British Sign Language Poetry.

    Science.gov (United States)

    Sutton-Spence, Rachel

    2001-01-01

    Focuses on the phonological deviance of the poetry of Dorothy Miles, who composed her work in both British Sign Language and English. Analysis is based on three poems performed by Miles herself. (Author/VWL)

  11. 10 Early Signs and Symptoms of Alzheimer's

    Science.gov (United States)

    ... be a symptom of Alzheimer's or another dementia . Alzheimer's is a brain disease that causes a slow decline in memory, thinking and reasoning skills. There are 10 warning signs and symptoms. Every individual may experience one or more of ...

  12. Naine objektistab meest / Fideelia-Signe Roots

    Index Scriptorium Estoniae

    Roots, Fideelia-Signe, 1976-

    2009-01-01

    Fideelia-Signe Roots Eesti Kunstiakadeemias 2009. a. kevadsemestril enda poolt läbi viidud valikainekursusest "Kunstiteose anatoomiast mehe anatoomiani", mis lõppes näitusega "Tõuseb / ei tõuse" Eesti Tervishoiumuuseumis, avatud 31. maini

  13. ELIMINATION AND IDENTITIES WITH THE INTEGRAL SIGN

    Institute of Scientific and Technical Information of China (English)

    Hongmei LIU; Tianming WANG

    2006-01-01

    In this paper, we aim at using the elimination in Weyl algebra to give an algorithm for proving the identities with integral sign. Then, we test several examples that have been proved by D Zeilberger.

  14. Dynamical properties of the Integral Sign galaxy.

    Science.gov (United States)

    Márquez, I.; Del Olmo, A.

    The galaxy A 0705+7155, called the Integral Sign because of its singular aspect, was spectroscopically examined. Physical conditions of the ISM, rotation curve, mass, morphological type, warps, and the distance of A 0705+7155 are discussed.

  15. The Babinski sign and the pyramidal syndrome.

    Science.gov (United States)

    Van Gijn, J

    1978-10-01

    The presence or absence of a Babinski sign can be puzzling, but in the light of existing pathological studies it is more fruitful to consider which pyramidal tract fibres release it than whether they release it. This was investigated clinically, by looking for correlations with other reflex changes and with motor deficits in the leg. A survey of 50 patients with a unilateral Babinski sign and six patients who lacked it in spite of other pyramidal tract signs was supplemented with follow-up of the patients who had acute lesions. Appearance of the Bibinski sign proved to depend on the interaction of two factors: (1) activity (not necessarily hyperactivity) in the segmental pathways of the flexion synergy; (2) a motor deficit of the foot, in some cases consisting only in an impairment of rapid foot movements, and probably representing a disturbance of direct pyramidal tract projections to distal motoneurones.

  16. Signs and Symptoms of Cervical Cancer

    Science.gov (United States)

    ... Detection, Diagnosis, and Staging Signs and Symptoms of Cervical Cancer Women with early cervical cancers and pre-cancers ... Ask Your Doctor About Cervical Cancer? More In Cervical Cancer About Cervical Cancer Causes, Risk Factors, and Prevention ...

  17. Signs and Symptoms of Thyroid Cancer

    Science.gov (United States)

    ... Detection, Diagnosis, and Staging Signs and Symptoms of Thyroid Cancer Thyroid cancer can cause any of the following ... Health Care Team About Thyroid Cancer? More In Thyroid Cancer About Thyroid Cancer Causes, Risk Factors, and Prevention ...

  18. CDC Vital Signs: Recipe for Food Safety

    Science.gov (United States)

    ... VitalSigns RSS Error processing SSI file Recipe for Food Safety Protecting people from deadly Listeria food poisoning Recommend ... for food production, like those included in the Food Safety Modernization Act (FSMA) , so that food doesn't ...

  19. Signs of learning in kinaesthetic science activities

    DEFF Research Database (Denmark)

    Bruun, Jesper; Johannsen, Bjørn Friis

    to couple an embodied experience of physics with the language of physics through dialogue. We propose that kinaesthetic learning is a way of integrating a bodily experience into a formal system of signs, in this case, force and motion in physics, but ask: to a teacher or researcher, what signs exist......The study addresses how students use communicative signs (e.g., speech and gesture) to shape and develop cognitive schemas during a bodily exploration of force and motion in a physics teaching-learning activity. We see ‘the experiential gestalt of causation’ as a cognitive element that may be used......?”). The analysis is conducted by searching the data to find episodes that illustrate student activity which can serve as a sign of the object that the ‘experiential gestalt of causation’ is employed in the construction of the intended learning outcome. In essence, we study a chaotic but authentic teaching...

  20. Working memory, deafness and sign language.

    Science.gov (United States)

    Rudner, Mary; Andin, Josefine; Rönnberg, Jerker

    2009-10-01

    Working memory (WM) for sign language has an architecture similar to that for speech-based languages at both functional and neural levels. However, there are some processing differences between language modalities that are not yet fully explained, although a number of hypotheses have been mooted. This article reviews some of the literature on differences in sensory, perceptual and cognitive processing systems induced by auditory deprivation and sign language use and discusses how these differences may contribute to differences in WM architecture for signed and speech-based languages. In conclusion, it is suggested that left-hemisphere reorganization of the motion-processing system as a result of native sign-language use may interfere with the development of the order processing system in WM.

  1. Holographic strange metals, entanglement and fermion signs

    CERN Document Server

    Kaplis, N; Zaanen, J

    2016-01-01

    The fermion sign problem is often viewed as a sheer inconvenience that plagues numerical studies of strongly interacting electron systems. Only recently, it has been suggested that fermion signs are fundamental for the universal behavior of critical metallic systems and crucially enhance their degree of quantum entanglement. In this work we explore potential connections between emergent scale invariance of fermion sign structures and scaling properties of bipartite entanglement entropies. Our analysis is based on a wavefunction ansatz that incorporates collective, long-range backflow correlations into fermionic Slater determinants. Such wavefunctions mimic the collapse of a Fermi liquid at a quantum critical point. Their nodal surfaces -- a representation of the fermion sign structure in many-particle configurations space -- show fractal behavior up to a length scale $\\xi$ that diverges at a critical backflow strength. We show that the Hausdorff dimension of the fractal nodal surface depends on $\\xi$, the num...

  2. Sign Changing Solutions of the ()-Laplacian Equation

    Indian Academy of Sciences (India)

    Bin Ge

    2013-11-01

    This paper deals with the variational and Nehari manifold method for the ()-Laplacian equations in a bounded domain or in the whole space. We prove existence of sign changing solutions under certain conditions.

  3. Studies in Rheoencephalography (REG)

    Science.gov (United States)

    2010-04-01

    Rheoencephalography and plethysmographic methods. Excerpta, Amsterdam. 1969. 25. Yarullin HH. Clinical rheoencephalography. Medicina , Leningrad. 1967...in Russian). Medicina , Leningrad. 1975. 32. Bodo M, Racz J, Ilias L, Pasztor A, Vajda J, Weinstein GB, Pasztor E, Moskalenko YE

  4. BacillusRegNet

    DEFF Research Database (Denmark)

    Misirli, Goksel; Hallinan, Jennifer; Röttger, Richard;

    2014-01-01

    As high-throughput technologies become cheaper and easier to use, raw sequence data and corresponding annotations for many organisms are becoming available. However, sequence data alone is not sufficient to explain the biological behaviour of organisms, which arises largely from complex molecular...

  5. Die reg op lewe

    Directory of Open Access Journals (Sweden)

    J.M. Vorster

    2002-08-01

    Full Text Available The right to life This article deals with the practical application of the fundamental right to life with special focus on abortion, capital punishment and euthanasia. From a Christian ethical perspective and the biblical principle of life it is argued that the practice of abortion, capital punishment and euthanasia cannot be justified for various reasons. Christians should therefore consider other ways to deal with issues like unwanted pregnancies and suffering. Regarding serious crime, punitive measures other than capital punishment ought to be considered because the practice of capital punishment can be misused by the state and can lead to the abuse of power. Capital punishment is also detrimental to the development of a culture of respect for life in society at large.

  6. Malta to sign MOU with CERN

    CERN Multimedia

    2008-01-01

    In what can be described as a historic moment for Malta's scientific sector, Prime Minister Lawrence Gonzi will today sign a memorandum of understanding with CERN that will start off a long-term participation project for Maltese engineers and scientists in research and innovation projects. The Prime Minister left yesterday, accompanied by government officials and University of Malta representatives, to sign the memorandum of understanding and initiate a series of discussions about further collaboration.

  7. Signed Young's Rule and Semistandard Homomorphisms

    OpenAIRE

    Lim, Kay Jin; Tan, Kai Meng

    2016-01-01

    We show that a signed Young permutation module $M(\\alpha|\\beta)$ has a Specht filtration in which a Specht module $S^\\lambda$ appears with a multiplicity given by the number of semistandard $\\lambda$-tableaux of type $(\\alpha|\\beta)$. We also construct a class of homomorphisms from a Specht module to a signed Young permutation module which generalise James' semistandard homomorphisms. The semistandard homomorphisms we have constructed form a basis for the space $\\mathrm{Hom}_{\\mathbb{F}\\mathf...

  8. The sagging rope sign: a critical appraisal.

    Science.gov (United States)

    Clarke, N M; Harrison, M H; Keret, D

    1983-05-01

    Certain features of the sagging rope sign recently analysed by Apley and Weintroub (1981) are examined in detail. Evidence is presented to show that the line is a radiological shadow cast by the lateral edge of a severely deformed femoral head rather than a condensation of the spongiosa within the neck. An explanation is offered to explain the common association of the presence of this radiological sign with premature epiphysial fusion.

  9. Multi-year Simulations and Experimental Seasonal Predictions for Rainy Seasons in China by Using a Nested Regional Climate Model (RegCM_NCC). Part Ⅰ: Sensitivity Study

    Institute of Scientific and Technical Information of China (English)

    DING Yihui; SHI Xueli; LIU Yiming; LIU Yan; LI Qingquan; QIAN Yongfu; MIAO Manqian; ZHAI Guoqing; GAO Kun

    2006-01-01

    A modified version of the NCAR/RegCM2 has been developed at the National Climate Center (NCC), China Meteorological Administration, through a series of sensitivity experiments and multi-year simulations and hindcasts, with a special emphasis on the adequate choice of physical parameterization schemes suitable for the East Asian monsoon climate. This regional climate model is nested with the NCC/IAP (Institute of Atmospheric Physics) T63 coupled GCM to make an experimental seasonal prediction for China and East Asia. The four-year (2001 to 2004) prediction results are encouraging. This paper is the first part of a two-part paper, and it mainly describes the sensitivity study of the physical process parameterization represented in the model. The systematic errors produced by the different physical parameterization schemes such as the land surface processes, convective precipitation, cloud-radiation transfer process, boundary layer process and large-scale terrain features have been identified based on multi-year and extreme flooding event simulations. A number of comparative experiments has shown that the mass flux scheme (MFS) and Betts-Miller scheme (BM) for convective precipitation, the LPMI (land surface process model I) and LPMII (land surface process model Ⅱ) for the land surface process, the CCM3 radiation transfer scheme for cloud-radiation transfer processes, the TKE (turbulent kinetic energy) scheme for the boundary layer processes and the topography treatment schemes for the Tibetan Plateau are suitable for simulations and prediction of the East Asia monsoon climate in rainy seasons. Based on the above sensitivity study, a modified version of the RegCM2 (RegCM_NCC) has been set up for climate simulations and seasonal predictions.

  10. Sensitivity of the Himalayan orography representation in simulation of winter precipitation using Regional Climate Model (RegCM) nested in a GCM

    Science.gov (United States)

    Tiwari, P. R.; Kar, S. C.; Mohanty, U. C.; Dey, S.; Sinha, P.; Shekhar, M. S.

    2017-02-01

    The role of the Himalayan orography representation in a Regional Climate Model (RegCM4) nested in NCMRWF global spectral model is examined in simulating the winter circulation and associated precipitation over the Northwest India (NWI; 23°-37.5°N and 69°-85°E) region. For this purpose, nine different set of orography representations for nine distinct precipitation years (three years each for wet, normal and dry) have been considered by increasing (decreasing) 5, 10, 15, and 20% from the mean height (CNTRL) of the Himalaya in RegCM4 model. Validation with various observations revealed a good improvement in reproducing the precipitation intensity and distribution with increased model height compared to the results obtained from CNTRL and reduced orography experiments. Further it has been found that, increase in height by 10% (P10) increases seasonal precipitation about 20%, while decrease in height by 10% (M10) results around 28% reduction in seasonal precipitation as compared to CNTRL experiment over NWI region. This improvement in precipitation simulation comes due to better representation of vertical pressure velocity and moisture transport as these factors play an important role in wintertime precipitation processes over NWI region. Furthermore, a comparison of model-simulated precipitation with observed precipitation at 17 station locations has been also carried out. Overall, the results suggest that when the orographic increment of 10% (P10) is applied on RegCM4 model, it has better skill in simulating the precipitation over the NWI region and this model is a useful tool for further regional downscaling studies.

  11. On the temporal dynamics of sign production: An ERP study in Catalan Sign Language (LSC).

    Science.gov (United States)

    Baus, Cristina; Costa, Albert

    2015-06-03

    This study investigates the temporal dynamics of sign production and how particular aspects of the signed modality influence the early stages of lexical access. To that end, we explored the electrophysiological correlates associated to sign frequency and iconicity in a picture signing task in a group of bimodal bilinguals. Moreover, a subset of the same participants was tested in the same task but naming the pictures instead. Our results revealed that both frequency and iconicity influenced lexical access in sign production. At the ERP level, iconicity effects originated very early in the course of signing (while absent in the spoken modality), suggesting a stronger activation of the semantic properties for iconic signs. Moreover, frequency effects were modulated by iconicity, suggesting that lexical access in signed language is determined by the iconic properties of the signs. These results support the idea that lexical access is sensitive to the same phenomena in word and sign production, but its time-course is modulated by particular aspects of the modality in which a lexical item will be finally articulated.

  12. The first sign of loss of consciousness.

    Science.gov (United States)

    Whinnery, Typ; Forster, Estrella M

    2017-10-01

    The first clinically observable sign of an unconsciousness episode (UNCE) serves as the temporal sequence (kinetics) onset point for neurological events occurring during the loss of consciousness, unconsciousness and recovery of consciousness phases of the UNCE. The initial neurologic signs of 212 individuals exposed to gradual (N=114) and rapid (N=98) onset +Gz acceleration stress, inducing the ischemic LOC phase in 83.3±18.6s and 8.89±1.52s; p0.1 for gradual and rapid onset +Gz-stress, respectively. Cerebral autoregulation may play a role in determination of ischemic UNCE induction and recovery. Five signs: loss of muscle control, eyelid closure, eye fixation, upward eye deviation, and muscular twitching occurred at LOC phase onset. The most frequent initial sign of LOC phase onset was loss of muscle control (84% of the episodes), followed by eye fixation (8.5%), and upward eye deviation (6.1%). Signs play a key role in differential diagnosis of syncopal, epileptic, psychogenic and other causes of UNCEs. Sign kinetics may provide insight into localization of the essential components and networks within the cephalic nervous system associated with UNCEs. Copyright © 2017 Elsevier Inc. All rights reserved.

  13. [C-sign and talocalcaneal coalition].

    Science.gov (United States)

    Tomčovčík, L

    2011-01-01

    Talocalcaneal coalition is an abnormal bridge between talus and calcaneus, causing pain and restriction of subtalar movement; its incidence is less than 1 %. The signs and symptoms usually become manifest in the second decade of life with ossification of the lesion. They involve flat foot, peroneal muscle spasm, tarsal tunnel syndrome, or valgus tilt of the heel. The sings need not be noticeable and may appear only as tiredness and vague pain in the hind foot after exercise or an easily twisted ankle. The authors describe the case of talocalcaneal coalition in a 20-year-old man, incidentally diagnosed at ankle fracture. The presence of C-sign led to CT examination and the exact diagnosis. Radiological demonstration of this abnormality may be difficult because plain X-ray images in both projections may show normal findings. Literature data report, in addition to C-sign, further secondary signs of talocalcaneal coalition present on lateral radiographs of the ankle joint. Although these signs do not directly point to talocalcaneal coalition, they reveal abnormal anatomy or movement of the joint and may initiate more thorough examination by CT or MRI and the establishment of an exact diagnosis. Therefore, to know the secondary signs and pay attention to them is very useful.

  14. Epidemic spreading on evolving signed networks

    Science.gov (United States)

    Saeedian, M.; Azimi-Tafreshi, N.; Jafari, G. R.; Kertesz, J.

    2017-02-01

    Most studies of disease spreading consider the underlying social network as obtained without the contagion, though epidemic influences people's willingness to contact others: A "friendly" contact may be turned to "unfriendly" to avoid infection. We study the susceptible-infected disease-spreading model on signed networks, in which each edge is associated with a positive or negative sign representing the friendly or unfriendly relation between its end nodes. In a signed network, according to Heider's theory, edge signs evolve such that finally a state of structural balance is achieved, corresponding to no frustration in physics terms. However, the danger of infection affects the evolution of its edge signs. To describe the coupled problem of the sign evolution and disease spreading, we generalize the notion of structural balance by taking into account the state of the nodes. We introduce an energy function and carry out Monte Carlo simulations on complete networks to test the energy landscape, where we find local minima corresponding to the so-called jammed states. We study the effect of the ratio of initial friendly to unfriendly connections on the propagation of disease. The steady state can be balanced or a jammed state such that a coexistence occurs between susceptible and infected nodes in the system.

  15. The Babinski sign--a reappraisal.

    Directory of Open Access Journals (Sweden)

    Kumar S

    2000-10-01

    Full Text Available In 1896, Joseph Babinski, a French neurologist, first described the best known neurologic eponym ′the Babinski sign′. This sign is characterised by dorsiflexion of the big toe and recruitment of the extensor hallucis longus muscle, on stimulating the sole of the foot. He has emphasised from the outset, the intimate relationship between this sign and the shortening movement in other leg muscles, which form the flexion synergy of the lower limb. The Babinski sign is not a new reflex, rather it is released as a result of breakdown of the harmonious integration of the flexion and extension components of the normal defence reflex mechanism, due to pyramidal tract dysfunction. A pathological Babinski sign should be clearly distinguished from upgoing toes that may not always be a part of the flexion synergy. This article reviews the Babinski sign in detail, focusing on the historical perspectives, role of pyramidal tract dysfunction and art of elicitation and interpretation. The significance of assessing this phenomenon in the entire leg, and the clinical clues that will help to dispel the myths regarding the Babinski sign, have been emphasised.

  16. Gesture, sign and language: The coming of age of sign language and gesture studies.

    Science.gov (United States)

    Goldin-Meadow, Susan; Brentari, Diane

    2015-10-05

    How does sign language compare to gesture, on the one hand, and to spoken language on the other? At one time, sign was viewed as nothing more than a system of pictorial gestures with no linguistic structure. More recently, researchers have argued that sign is no different from spoken language with all of the same linguistic structures. The pendulum is currently swinging back toward the view that sign is gestural, or at least has gestural components. The goal of this review is to elucidate the relationships among sign language, gesture, and spoken language. We do so by taking a close look not only at how sign has been studied over the last 50 years, but also at how the spontaneous gestures that accompany speech have been studied. We come to the conclusion that signers gesture just as speakers do. Both produce imagistic gestures along with more categorical signs or words. Because, at the moment, it is difficult to tell where sign stops and where gesture begins, we suggest that sign should not be compared to speech alone, but should be compared to speech-plus-gesture. Although it might be easier (and, in some cases, preferable) to blur the distinction between sign and gesture, we argue that making a distinction between sign (or speech) and gesture is essential to predict certain types of learning, and allows us to understand the conditions under which gesture takes on properties of sign, and speech takes on properties of gesture. We end by calling for new technology that may help us better calibrate the borders between sign and gesture.

  17. El tipo de cambio real y los regímenes cambiarios en México durante el periodo 1954-2010

    Directory of Open Access Journals (Sweden)

    Mario Gómez Aguirre

    2011-06-01

    Full Text Available En este artículo se analiza el comportamiento del tipo de cambio real y los regímenes cambiarios entre México y Estados Unidos durante el período 1954-2010. Los resultados indican los fuertes movimientos de la inflación y del tipo de cambio en la década de los ochenta y noventas. Después de la aplicación del régimen de libre flotación, el tipo de cambio y la tasa inflación han mostrado una mayor estabilidad.

  18. Género, literatura y memoria en la España del último entresiglos : Eduardo Mendicutti, Rosa Regàs y Rosa Montero

    OpenAIRE

    Bonatto, Adriana Virginia

    2014-01-01

    Esta investigación se propone estudiar las representaciones del pasado reciente y los procesos literarios de reapropiación de la memoria colectiva en una selección de novelas pertenecientes a Eduardo Mendicutti (El palomo cojo, de 1991), Rosa Montero (La hija del caníbal, publicada en 1997), Rosa Regás (Luna lunera, de 1999) como exponentes, las dos últimas, de la narrativa española escrita por mujeres durante la década del noventa y, en el caso de Mendicutti, del giro queer que protagoniza l...

  19. Reg Ⅳ基因对5-FU干预结直肠癌LoVo细胞增殖、凋亡的影响%Effect of Reg Ⅳ gene on 5-Fluorouracil intervened human colorectal carcinoma cell line LoVo proliferation and apoptosis

    Institute of Scientific and Technical Information of China (English)

    郭英; 李楠; 徐佳佳; 高峰; 黄培林

    2009-01-01

    目的 观察Reg Ⅳ基因对5-FU干预结直肠癌LoVo细胞增殖、凋亡的影响.方法 构建重组质粒pcDNA3.1-RegⅣ并转染LoVo细胞,RT-PCR和细胞免疫组化检测转染前后细胞中Reg Ⅳ基因的mRNA和蛋白表达.终浓度80 μmol/L的5-FU干预细胞48 h后,MTT检测细胞的增殖活性.平板克隆实验观察细胞的克隆形成能力.FCM检测细胞凋亡.结果 LoVo细胞不表达Reg Ⅳ基因,转染后的LoVo/RegⅣ细胞高表达RegⅣ.5-FU干预后,未转染组(LoVo)和空转质粒组(LoVo/空载)细胞增殖活性、克隆形成能力较RegⅣ转染组(LoVo/RegⅣ)明显降低(P<0.05),细胞凋亡率较RegⅣ转染组明显升高(P<0.05).结论 RegⅣ基因表达可能降低5-FU抑制LoVo细胞的增殖活性及克隆形成能力,并能抑制5-FU诱导LoVo细胞凋亡的作用.Reg Ⅳ基因可能是患者对5-FU化疗产生抗药性的标志及导致临床化疗失败的原因之一.

  20. Comparative Study of a Real-Time PCR Assay Targeting senX3-regX3 versus Other Molecular Strategies Commonly Used in the Diagnosis of Tuberculosis.

    Directory of Open Access Journals (Sweden)

    Rocio Sanjuan-Jimenez

    Full Text Available Nucleic acid amplification tests are increasingly used for the rapid diagnosis of tuberculosis. We undertook a comparative study of the efficiency and diagnostic yield of a real-time PCR senX3-regX3 based assay versus the classical IS6110 target and the new commercial methods.This single-blind prospective comparative study included 145 consecutive samples: 76 from patients with culture-confirmed tuberculosis (86.8% pulmonary and 13.2% extrapulmonary tuberculosis: 48.7% smear-positive and 51.3% smear-negative and 69 control samples (24 from patients diagnosed with non-tuberculous mycobacteria infections and 45 from patients with suspected tuberculosis which was eventually ruled out. All samples were tested by two CE-marked assays (Xpert®MTB/RIF and AnyplexTM plus MTB/NTM and two in-house assays targeting senX3-regX3 and the IS6110 gene.The detection limit ranged from 1.00E+01 fg for Anyplex, senX3-regX3 and IS6110 to 1.00E+04 fg for Xpert. All three Xpert, senX3-regX3 and IS6110 assays detected all 37 smear-positive cases. Conversely, Anyplex was positive in 34 (91.9% smear-positive cases. In patients with smear-negative tuberculosis, differences were observed between the assays; Xpert detected 22 (56.41% of the 39 smear-negative samples, Anyplex 24 (61.53%, senX3-regX3 28 (71.79% and IS6110 35 (89.74%. Xpert and senX3-regX3 were negative in all control samples; however, the false positive rate was 8.7% and 13% for Anyplex and IS6110, respectively. The overall sensitivity was 77.6%, 85.7%, 77.3% and 94.7% and the specificity was 100%, 100%, 90.8% and 87.0% for the Xpert, senX3-regX3, Anyplex and IS6110 assays, respectively.Real-time PCR assays targeting IS6110 lack the desired specificity. The Xpert MTB/RIF and in-house senX3-regX3 assays are both sensitive and specific for the detection of MTBC in both pulmonary and extrapulmonary samples. Therefore, the real time PCR senX3-regX3 based assay could be a useful and complementary tool in the

  1. Segmentation of British Sign Language (BSL): Mind the gap!

    NARCIS (Netherlands)

    Orfanidou, E.; McQueen, J.M.; Adam, R.; Morgan, G.

    2015-01-01

    This study asks how users of British Sign Language (BSL) recognize individual signs in connected sign sequences. We examined whether this is achieved through modality-specific or modality-general segmentation procedures. A modality-specific feature of signed languages is that, during continuous sign

  2. What Name Signs Can Tell Us about Deaf Culture.

    Science.gov (United States)

    Mindess, Anna

    1990-01-01

    Twenty deaf adults were interviewed about their use of name signs. Results revealed underlying cultural values expressed in name signs, and also provided practical information about the making and bestowing of name signs, changing one's name sign, and evolution in the name sign system. (Author/CB)

  3. Characterization of the duplicate L-SIGN and DC-SIGN genes in miiuy croaker and evolutionary analysis of L-SIGN in fishes.

    Science.gov (United States)

    Shu, Chang; Wang, Shanchen; Xu, Tianjun

    2015-05-01

    Dendritic cell-specific ICAM-3-grabbing non-integrin (DC-SIGN/CD209) and liver/lymph node-specific ICAM-grabbing non-integrin (L-SIGN/CD299) which are homologues of DC-SIGN are important members in C-type lectin receptors family as key molecules to recognize and eliminate pathogens in the innate immune system. DC-SIGN and L-SIGN have become hot topics in recent studies which both served as cell adhesion and phagocytic pathogen recognition receptors in mammals. However, there have been almost no studies of DC-SIGN and L-SIGN structure and characters in fish, only DC-SIGN in the zebrafish had been studied. In our study, we identified and characterized the full-length miiuy croaker (Miichthys miiuy) DC-SIGN (mmDC-SIGN) and L-SIGN (mmL-SIGN) genes. The sequence analysis results showed that mmDC-SIGN and mmL-SIGN have the same domains with other vertebrates except primates, and share some conserved motifs in CRD among all the vertebrates which play a crucial role in interacting with Ca(2+) and for recognizing mannose-containing motifs. Gene synteny of DC-SIGN and L-SIGN were analyzed for the first time and gene synteny of L-SIGN was conserved among the five fishes. Interestingly, one gene next to L-SIGN from gene synteny had high similarity with L-SIGN gene that was described as L-SIGN-like in fish species. While only one L-SIGN gene existed in other vertebrates, two L-SIGN in fish may be in consequence of the fish-specific genome duplication to adapt the specific environment. The evolutionary analysis showed that the ancestral lineages of L-SIGN gene in fishes experienced purifying selection and the current lineages of L-SIGN gene in fishes underwent positive selection, indicating that the ancestral lineages and current lineages of L-SIGN gene in fishes underwent different evolutionary patterns. Both mmDC-SIGN and mmL-SIGN were expressed in all tested tissues and ubiquitously up-regulated in infected liver, spleen and kidney at different sampling time points

  4. The use of dilute calogen[reg] as a fat density oral contrast medium in upper abdominal computed tomography, compared with the use of water and positive oral contrast media

    Energy Technology Data Exchange (ETDEWEB)

    Ramsay, Duncan W.; Markham, Derrian H.; Morgan, Bruno; Rodgers, Peter M.; Liddicoat, Amanda J

    2001-08-01

    AIM: Oral contrast media are commonly given prior to computed tomography (CT) examination of the upper abdomen. Although positive oral contrast media are normally used, there is increasing interest in using negative agents such as water and less commonly fat density products. The aim of this study was to compare a positive oral contrast medium, water, and a diluted emulsion of arachis oil (Calogen[reg], a fat density food supplement) for assessment of the upper abdomen. MATERIALS AND METHODS: Seventy-one patients referred for upper abdominal CT were randomized to receive either 500 ml water, 2% sodium diatrizoate or a dilute suspension of Calogen[reg]. The CT images were scored independently by three radiologists. Distension and anatomical identification was assessed for the stomach, duodenum and jejunum; with anatomical identification recorded for the pancreas, retroperitoneum, liver, gallbladder and spleen. RESULTS: Dilute Calogen[reg] produced a significant improvement (P < 0.01) in distension and anatomical visualization of the stomach and proximal duodenum. Only minimal differences were demonstrated between the three contrast media for visualization of more distal small bowel or identification of the other upper abdominal viscera. Significantly more artifacts were caused by positive contrast media than with the Calogen[reg] mixture. CONCLUSION: A dilute suspension of Calogen[reg] as an oral contrast medium is recommended when disease is suspected within the stomach or proximal duodenum. Ramsay, D.W. et al. (2001)

  5. Adaptation of a Vocabulary Test from British Sign Language to American Sign Language

    OpenAIRE

    Mann, W.; Roy, P; Morgan, G

    2016-01-01

    This study describes the adaptation process of a vocabulary knowledge test for British Sign Language (BSL) into American Sign Language (ASL) and presents results from the first round of pilot testing with twenty deaf native ASL signers. The web-based test assesses the strength of deaf children’s vocabulary knowledge by means of different mappings of phonological form and meaning of signs. The adaptation from BSL to ASL involved nine stages, which included forming a panel of deaf/hearing exper...

  6. Adapting the Assessing British Sign Language Development: Receptive Skills Test into American sign language.

    Science.gov (United States)

    Enns, Charlotte J; Herman, Rosalind C

    2011-01-01

    Signed languages continue to be a key element of deaf education programs that incorporate a bilingual approach to teaching and learning. In order to monitor the success of bilingual deaf education programs, and in particular to monitor the progress of children acquiring signed language, it is essential to develop an assessment tool of signed language skills. Although researchers have developed some checklists and experimental tests related to American Sign Language (ASL) assessment, at this time a standardized measure of ASL does not exist. There have been tests developed in other signed languages, for example, British Sign Language, that can serve as models in this area. The purpose of this study was to adapt the Assessing British Sign Language Development: Receptive Skills Test for use in ASL in order to begin the process of developing a standardized measure of ASL skills. The results suggest that collaboration between researchers in different signed languages can provide a valuable contribution toward filling the gap in the area of signed language assessment.

  7. On the System of Place Name Signs in Estonian Sign Language

    Directory of Open Access Journals (Sweden)

    Liina Paales

    2010-12-01

    Full Text Available A place name sign is a linguistic-cultural marker that includes both memory and landscape. The author regards toponymic signs in Estonian Sign Language as representations of images held by the Estonian Deaf community: they reflect the geographical place, the period, the relationships of the Deaf community with hearing community, and the common and distinguishing features of the two cultures perceived by community's members. Name signs represent an element of signlore, which includes various types of creative linguistic play. There are stories hidden behind the place name signs that reveal the etymological origin of place name signs and reflect the community's memory. The purpose of this article is twofold. Firstly, it aims to introduce Estonian place name signs as Deaf signlore forms, analyse their structure and specify the main formation methods. Secondly, it interprets place-denoting signs in the light of understanding the foundations of Estonian Sign Language, Estonian Deaf education and education history, the traditions of local Deaf communities, and also of the cultural and local traditions of the dominant hearing communities. Both perspectives - linguistic and folkloristic - are represented in the current article.

  8. What Are the Signs and Symptoms of Aplastic Anemia?

    Science.gov (United States)

    ... What Are the Signs and Symptoms of Aplastic Anemia? Lower than normal numbers of red blood cells, ... most of the signs and symptoms of aplastic anemia. Signs and Symptoms of Low Blood Cell Counts ...

  9. What Are the Signs and Symptoms of Sarcoidosis?

    Science.gov (United States)

    ... Twitter. What Are the Signs and Symptoms of Sarcoidosis? Many people who have sarcoidosis have no signs ... symptom is more common in women than men. Sarcoidosis Signs and Symptoms The illustration shows the major ...

  10. Introducing Sign Language Systems to Parents of Young Deaf Children.

    Science.gov (United States)

    Moser, Barbara Walsh

    1987-01-01

    The three major sign language systems (American Sign Language, Pidgin Sign English, and Manual English) are compared in table form. A brief description of each language highlights salient points that parents of deaf children need to understand. (DB)

  11. The vital signs of chronic disease management.

    Science.gov (United States)

    Harries, Anthony D; Zachariah, Rony; Kapur, Anil; Jahn, Andreas; Enarson, Donald A

    2009-06-01

    The vital signs of pulse rate, blood pressure, temperature and respiratory rate are the 'nub' of individual patient management. At the programmatic level, vital signs could also be used to monitor the burden and treatment outcome of chronic disease. Case detection and treatment outcome constitute the vital signs of tuberculosis control within the WHO's 'DOTS' framework, and similar vital signs could be adapted and used for management of chronic diseases. The numbers of new patients started on therapy in each month or quarter (new incident cases) are sensitive indicators for programme performance and access to services. Using similar reporting cycles, treatment outcomes for all patients can be assessed, the vital signs being: alive and retained on therapy at the respective facility; died; stopped therapy; lost to follow-up; and transferred out to another facility. Retention on treatment constitutes the prevalent number of cases, the burden of disease, and this provides important strategic information for rational drug forecasting and logistic planning. If case numbers and outcomes of chronic diseases were measured reliably and consistently as part of an integrated programmatic approach, this would strengthen the ability of resource-poor countries to monitor and assess their response to these growing epidemics.

  12. Modelling the Caspian Sea and its catchment area using a coupled regional atmosphere-ocean model (RegCM4-ROMS: model design and preliminary results

    Directory of Open Access Journals (Sweden)

    U. U. Turuncoglu

    2013-03-01

    Full Text Available We describe the development of a coupled regional atmosphere-ocean model (RegCM4-ROMS and its implementation over the Caspian Sea basin. The coupled model is run for the period 1999–2008 (after a spin up of 4 yr and it is compared to corresponding stand alone model simulations and a simulation in which a distributed 1d lake model is run for the Caspian Sea. All model versions show a good performance in reproducing the climatology of the Caspian Sea basin, with relatively minor differences across them. The coupled ROMS produces realistic, although somewhat overestimated, Caspian Sea Surface Temperature (SST, with a considerable improvement compared to the use of the simpler coupled lake model. Simulated near surface salinity and sea currents are also realistic, although the upwelling over the eastern coastal regions is underestimated. The sea ice extent over the shallow northern shelf of the Caspian Sea and its seasonal evolution are well reproduced, however, a significant negative bias in sea-ice fraction exists due to the relatively poor representation of the bathymetry. ROMS also calculates the Caspian Sea Level (CSL, showing that for the present experiment excessive evaporation over the lake area leads to a drift in estimated CSL. Despite this problem, which requires further analysis due to many uncertainties in the estimation of CSL, overall the coupled RegCM4-ROMS system shows encouraging results in reproducing both the climatology of the region and the basic characteristics of the Caspian Sea.

  13. Propuestas metodológicas para la clasificación de los regímenes políticos

    Directory of Open Access Journals (Sweden)

    Philippe Lauvaux

    2009-06-01

    Full Text Available En este artículo el profesor Philippe Lauvaux, una de las voces más autorizadas de Europa en materia de parlamentarismo y regímenes políticos, reivindica la utilidad de su clasificación dicotómica clásica, que se estructura a partir de la oposición parlamentario/presidencial, luego de que ha sido el blanco de encendidos ataques teóricos que la han hecho caer en el descrédito. La defensa se realiza a partir de un razonamiento doble: un argumento que resalta la pertinencia de la clasificación en tanto reflejo de una realidad histórica concomitante con el surgimiento de la democracia moderna en Occidente; y uno de naturaleza funcional, que muestra las ventajas de la tipología como herramienta para la mejor comprensión del funcionamiento de los regímenes políticos, entendidos como estructuras institucionales a las que corresponde una lógica y economía propias de los principios de mayoría democrática y responsabilidad política.

  14. Propuestas metodológicas para la clasificación de los regímenes políticos

    Directory of Open Access Journals (Sweden)

    Philippe Lauvaux

    2009-07-01

    Full Text Available En este artículo el profesor Philippe Lauvaux, una de las voces más autorizadas de Europa en materia de parlamentarismo y regímenes políticos, reivindica la utilidad de su clasificación dicotómica clásica, que se estructura a partir de la oposición parlamentario/presidencial, luego de que ha sido el blanco de encendidos ataques teóricos que la han hecho caer en el descrédito. La defensa se realiza a partir de un razonamiento doble: un argumento que resalta la pertinencia de la clasificación en tanto reflejo de una realidad histórica concomitante con el surgimiento de la democracia moderna en Occidente; y uno de naturaleza funcional, que muestra las ventajas de la tipología como herramienta para la mejor comprensión del funcionamiento de los regímenes políticos, entendidos como estructuras institucionales a las que corresponde una lógica y economía propias de los principios de mayoría democrática y responsabilidad política.

  15. Multiyear simulation of the African climate using a regional climate model (RegCM3) with the high resolution ERA-interim reanalysis

    Energy Technology Data Exchange (ETDEWEB)

    Sylla, Mouhamadou Bamba [Cheikh Anta Diop University, Laboratory for Atmospheric Physics, Simeon Fongang (LPASF), Polytechnic School, BP 5085, Dakar (Senegal); Coppola, E.; Giorgi, F.; Bi, X. [International Centre for Theoretical Physics (ICTP), Physics of Weather and Climate Group, Earth System Physics Section, Trieste (Italy); Mariotti, L. [International Centre for Theoretical Physics (ICTP), Physics of Weather and Climate Group, Earth System Physics Section, Trieste (Italy); University of L' Aquila, Department of Physics, Centre of Excellence CETEMPS, L' Aquila (Italy); Ruti, P.M.; Dell' Aquila, A. [Casaccia Center, Ente per le Nuove Technologie, l' Energia e l' Ambiente (ENEA), Climate Section, Rome (Italy)

    2010-07-15

    This study examines the ability of the latest version of the International Centre for Theoretical Physics (ICTP) regional climate model (RegCM3) to reproduce seasonal mean climatologies, annual cycle and interannual variability over the entire African continent and different climate subregions. The new European Center for Medium Range Weather Forecast (ECMWF) ERA-interim reanalysis is used to provide initial and lateral boundary conditions for the RegCM3 simulation. Seasonal mean values of zonal wind profile, temperature, precipitation and associated low level circulations are shown to be realistically simulated, although the regional model still shows some deficiencies. The West Africa monsoon flow is somewhat overestimated and the Africa Easterly Jet (AEJ) core intensity is underestimated. Despite these biases, there is a marked improvement in these simulated model variables compared to previous applications of this model over Africa. The mean annual cycle of precipitation, including single and multiple rainy seasons, is well captured over most African subregions, in some cases even improving the quality of the ERA-interim reanalysis. Similarly, the observed precipitation interannual variability is well reproduced by the regional model over most regions, mostly following, and sometimes improving, the quality of the ERA-interim reanalysis. It is assessed that the performance of this model over the entire African domain is of sufficient quality for application to the study of climate change and climate variability over the African continent. (orig.)

  16. In vivo targeting of ADAM9 gene expression using lentivirus-delivered shRNA suppresses prostate cancer growth by regulating REG4 dependent cell cycle progression.

    Directory of Open Access Journals (Sweden)

    Che-Ming Liu

    Full Text Available Cancer cells respond to stress by activating a variety of survival signaling pathways. A disintegrin and metalloproteinase (ADAM 9 is upregulated during cancer progression and hormone therapy, functioning in part through an increase in reactive oxygen species. Here, we present in vitro and in vivo evidence that therapeutic targeting of ADAM9 gene expression by lentivirus-delivered small hairpin RNA (shRNA significantly inhibited proliferation of human prostate cancer cell lines and blocked tumor growth in a murine model of prostate cancer bone metastasis. Cell cycle studies confirmed an increase in the G1-phase and decrease in the S-phase population of cancer cells under starvation stress conditions, which correlated with elevated intracellular superoxide levels. Microarray data showed significantly decreased levels of regenerating islet-derived family member 4 (REG4 expression in prostate cancer cells with knockdown of ADAM9 gene expression. This REG4 downregulation also resulted in induction of expression of p21(Cip1/WAF1, which negatively regulates cyclin D1 and blocks the G1/S transition. Our data reveal a novel molecular mechanism of ADAM9 in the regulation of prostate cancer cell proliferation, and suggests a combined modality of ADAM9 shRNA gene therapy and cytotoxic agents for hormone refractory and bone metastatic prostate cancer.

  17. La problemática de las comisiones en la administración de los regímenes de pensiones latinoamericanos: especial referencia al sistema colombiano

    Directory of Open Access Journals (Sweden)

    Marjorie Zúñiga Romero

    2015-01-01

    Full Text Available Los nuevos modelos de regímenes de pensiones implantados a finales del siglo XX están siendo objeto de revisión, en todos sus elementos fundamen-tales, con el objetivo de detectar las deficiencias más significativas de su di-námica. Uno de los elementos que ha sido considerado para su reforma es la estructura de las comisiones que deben satisfacer los afiliados al régimen de ahorro individual a las administradoras de fondos de pensiones de su elec-ción. La valoración de la modalidad de comisión más eficiente en relación con los objetivos del sistema de pensiones, fundamentalmente la generación de pensiones de cuantía suficiente y adecuada, así como la expansión de su cobertura, se realiza a partir del análisis de las principales reformas que en esta materia han acometido los regímenes de pensiones del área latinoameri-cana. De entre las categorías de comisión, la basada en el salario del trabaja-dor presenta ventajas sobre el resto de modalidades en orden a la contención de gastos de las administradoras de fondos de pensiones y la cobertura del sistema de seguridad social.

  18. Information Theory Based KL-Reg Point Cloud Registration%基于信息论的KL-Reg点云配准算法

    Institute of Scientific and Technical Information of China (English)

    秦红星; 徐雷

    2015-01-01

    针对含有高噪声、体外点及不完整点云数据的配准失效问题,该文提出以信息论为理论基础,相对熵度量点云相似度的KL-Reg算法.该算法不需要显式地建立对应关系,首先将点云数据建模为高斯混合模型,然后用相对熵度量高斯混合模型间的分布距离,最后通过最小化分布距离计算模型变换.实验结果表明所提的KL-Reg算法配准精度高、稳定性强.%The registration of point clouds with high noises, outliers and missing data will be failure because the correspondence between point clouds is inaccurate. This paper proposes a information theory based point cloud registration method called KL-Reg algorithm without building correspondence. The method represents the point cloud with Gaussian mixture model, then computes the transformation through minimizing the KL divergence without build explicit correspondence. Experimental results show that KL-Reg algorithm is precise and stable.

  19. Changes of Atmospheric Water Balance over China under the IPCC SRES A1B Scenario Based on RegCM3 Simulations

    Institute of Scientific and Technical Information of China (English)

    SUN Bo; JIANG Da-Bang

    2012-01-01

    Simulations of the Regional Climate Model Version 3 (RegCM3) under the Intergovernmental Panel on Climate Change (IPCC) Special Report on Emissions Scenarios (SRES) A1B scenario were employed to investigate possible decadal changes and long-term trends of annual mean atmospheric water balance components over China in the 21st century with reference to the period of 1981-2000. An evaluation showed that RegCM3 can reasonably reproduce annual evapotranspiration, precipitation, and water vapor transport over China, with a better performance for March–June. It was found that the water vapor exchange between the land surface and atmosphere would be significantly intensified in Northwest China by the mid-to late-21st century and that the region would possibly shift to a wetter or drought-mitigated state under global warming. Conversely, the water vapor exchange evidently weakened over the Tibetan Plateau and South-west China by the mid-to late-21st century. In addition, there appears to be a drier state for Northeast China and the middle and lower reaches of the Yangtze River valley by the mid-to late-21st century, with slight mitigation by the end compared with the mid-21st century. The westerly and southwesterly water vapor transport over China generally presents an increasing trend, with increasing diver-gence over the Tibetan Plateau and Northeast China, corresponding to a loss of atmospheric water vapor by water vapor transport.

  20. Modeling the Caspian Sea and its catchment area using a coupled regional atmosphere-ocean model (RegCM-ROMS: model design and preliminary results

    Directory of Open Access Journals (Sweden)

    U. U. Turuncoglu

    2012-11-01

    Full Text Available We describe the development of a coupled regional atmosphere-ocean model (RegCM-ROMS and its implementation over the Caspian Sea basin. The coupled model is run for the period 1999–2008 (after a spin up of 4 yr and it is compared to corresponding stand alone model simulations and a simulation in which a distributed 1d lake model is run for the Caspian Sea. All model versions show a good performance in reproducing the climatology of the Caspian Sea basin, with relatively minor differences across them. The coupled ROMS produces realistic, although somewhat overestimated, lake surface temperatures (LSTs, with a considerable improvement compared to the use of the simpler coupled lake model. Simulated near surface salinity and sea currents are also realistic, although the upwelling over the eastern coastal regions is underestimated. The distribution of sea ice over the shallow northern shelf of the Caspian Sea and its seasonal evolution are well reproduced. ROMS also calculates the Caspian Sea Level (CSL, showing that for the present experiment excessive evaporation over the lake area leads to a drift in estimated CSL. Despite this problem which requires further analysis due to many uncertainties in the estimation of CSL, overall the coupled RegCM-ROMS system shows encouraging results in reproducing both the climatology of the region and the basic characteristics of the Caspian Sea.

  1. La defensa de regímenes populistas y autoritarios mediante el énfasis en las diferencias: el peligro de la regresión histórica

    Directory of Open Access Journals (Sweden)

    H.C.F. Mansilla

    2014-01-01

    Full Text Available El objetivo de este texto es mostrar que una de las mejores defensas teóricas de los regímenes populistas han resultado ser el relativismo cultural y los enfoques derivados del postmodernismo, que niegan la posibilidad de jerarquías histórico-evolutivas y establecen una diferencia básica e incomparable entre los distintos modelos sociales. Inspirada por la Escuela de Frankfurt, la metodología de este texto está basada en una crítica a los discursos relativistas y postmodernistas, los cuales impiden percibir los fenómenos de autoritarismo en los regímenes populistas, sobre todo en los casos actuales de Bolivia y Venezuela. Como resultado y conclusión principal se asevera que los regímenes populistas representan el camino de la involución histórica e institucional.

  2. What Are the Signs and Symptoms of Pneumonia?

    Science.gov (United States)

    ... Home » Health Information for the Public » Health Topics » Pneumonia » Signs, Symptoms, and Complications Explore Pneumonia Pneumonia Causes Risk Factors Signs, Symptoms, and Complications ...

  3. The "double panda" sign in Leigh disease.

    Science.gov (United States)

    Sonam, Kothari; Bindu, P S; Gayathri, Narayanappa; Khan, Nahid Akhtar; Govindaraju, C; Arvinda, Hanumanthapura R; Nagappa, Madhu; Sinha, Sanjib; Thangaraj, K; Taly, Arun B

    2014-07-01

    Although the "face of the giant panda" sign on magnetic resonance imaging (MRI) is traditionally considered to be characteristic of Wilson disease, it has also been reported in other metabolic disorders. This study describes the characteristic "giant panda" sign on MRI in a child with Leigh disease. The diagnosis was based on the history of neurological regression; examination findings of oculomotor abnormalities, hypotonia, and dystonia; raised serum lactate levels; and characteristic brain stem and basal ganglia signal changes on MRI. The midbrain and pontine tegmental signal changes were consistent with the "face of the giant panda and her cub" sign. In addition to Wilson disease, metabolic disorders such as Leigh disease should also be considered in the differential diagnosis of this rare imaging finding.

  4. Sign Stability via Root Locus Analysis

    CERN Document Server

    Gibson, Travis E

    2015-01-01

    With the rise of network science old topics in ecology and economics are resurfacing. One such topic is structural stability (often referred to as qualitative stability or sign stability). A system is deemed structurally stable if the system remains stable for all possible parameter variations so long as the parameters do not change sign. This type of stability analysis is appealing when studying real systems as the underlying stability result only requires the scientist or engineer to know the sign of the parameters in the model and not the specific values. The necessary and sufficient conditions for qualitative stability however are opaque. In order to shed light on those conditions root locus analysis is employed. This technique allows us to illustrate the necessary conditions for qualitative stability.

  5. Sign ambiguity in the K Sigma channel

    CERN Document Server

    Anisovich, A V; Nikonov, V A; Sarantsev, A V; Thoma, U

    2013-01-01

    Ambiguities of the signs of $N\\to \\Sigma K$ coupling constants are studied in a multichannel partial wave analysis of a large body of pion and photo-induced reactions. It is shown that the signs are not free from some ambiguities, and further experimental data are needed. Data on the reactions $\\pi^+p\\to \\Sigma^+K^+$ and $\\gamma p\\to K^+\\Sigma^0$ define rather well the isospin 3/2 contributions to these channels. However the lack of information on polarization observables for the reactions $\\pi^-p\\to \\Sigma^0K^0$, $\\pi^-p\\to \\Sigma^-K^+$ and $\\gamma p\\to K^0\\Sigma^+$ does not allow us to fix uniquely the signs of $N\\to \\Sigma K$ coupling constants. As a consequence, also the contributions of nucleon resonances to these channels remain uncertain.

  6. English Shop Signs and Brand Names

    Directory of Open Access Journals (Sweden)

    Hemaseh Bagheri Sanjareh

    2011-10-01

    Full Text Available

    The present study tries to investigate the people’s attitude to the use of English words in TV commercials, brand-naming and shop signs in Iran and specifically in Tehran where due to the fact that it is the capital, more English might be used for the sake of foreigners. The widespread use of English shop signs and English brand names for recently produced goodsdrove the researchers to investigate peoples’ attitude as consumers from two aspects of age and education. To reach the research goal, a questionnaire was devised and distributed to 100 people at random selection probing their attitudes while considering two factors of age and education. The result of the research will mostly benefit sociolinguists and business marketers.

    Keywords: age, education, advertising, brand-naming, shop signs, globalization

  7. A Sign Language Screen Reader for Deaf

    Science.gov (United States)

    El Ghoul, Oussama; Jemni, Mohamed

    Screen reader technology has appeared first to allow blind and people with reading difficulties to use computer and to access to the digital information. Until now, this technology is exploited mainly to help blind community. During our work with deaf people, we noticed that a screen reader can facilitate the manipulation of computers and the reading of textual information. In this paper, we propose a novel screen reader dedicated to deaf. The output of the reader is a visual translation of the text to sign language. The screen reader is composed by two essential modules: the first one is designed to capture the activities of users (mouse and keyboard events). For this purpose, we adopted Microsoft MSAA application programming interfaces. The second module, which is in classical screen readers a text to speech engine (TTS), is replaced by a novel text to sign (TTSign) engine. This module converts text into sign language animation based on avatar technology.

  8. [Information technology in learning sign language].

    Science.gov (United States)

    Hernández, Cesar; Pulido, Jose L; Arias, Jorge E

    2015-01-01

    To develop a technological tool that improves the initial learning of sign language in hearing impaired children. The development of this research was conducted in three phases: the lifting of requirements, design and development of the proposed device, and validation and evaluation device. Through the use of information technology and with the advice of special education professionals, we were able to develop an electronic device that facilitates the learning of sign language in deaf children. This is formed mainly by a graphic touch screen, a voice synthesizer, and a voice recognition system. Validation was performed with the deaf children in the Filadelfia School of the city of Bogotá. A learning methodology was established that improves learning times through a small, portable, lightweight, and educational technological prototype. Tests showed the effectiveness of this prototype, achieving a 32 % reduction in the initial learning time for sign language in deaf children.

  9. Brazilian Sign Language Lexicography and Technology: Dictionary, Digital Encyclopedia, Chereme-based Sign Retrieval, and Quadriplegic Deaf Communication Systems.

    Science.gov (United States)

    Capovilla, Fernando C.; Duduchi, Marcelo; Raphael, Walkiria D.; Luz, Renato D.; Rozados, Daniela; Capovilla, Alessandra G. S.; Macedo, Elizeu C.

    2003-01-01

    Discusses the Brazilian Sign language digital encyclopedia, which contains a databank of 5,600 signs glossed in Portuguese and English, along with descriptions and illustrations of their signed form. (Author/VWL)

  10. An Assessment of the South Asian Summer Monsoon Variability for Present and Future Climatologies Using a High Resolution Regional Climate Model (RegCM4.3 under the AR5 Scenarios

    Directory of Open Access Journals (Sweden)

    Mujtaba Hassan

    2015-11-01

    Full Text Available We assessed the present and future climatologies of mean summer monsoon over South Asia using a high resolution regional climate model (RegCM4 with a 25 km horizontal resolution. In order to evaluate the performance of the RegCM4 for the reference period (1976–2005 and for the far future (2070–2099, climate change projections under two greenhouse gas representative concentration pathways (RCP4.5 and RCP8.5 were made, the lateral boundary conditions being provided by the geophysical fluid dynamic laboratory global model (GFDL-ESM2M. The regional climate model (RCM improves the simulation of seasonal mean temperature and precipitation patterns compared to driving global climate model (GCM during present-day climate conditions. The regional characteristic features of South Asian summer monsoon (SASM, like the low level jet stream and westerly flow over the northern the Arabian Sea, are well captured by the RegCM4. In spite of some discrepancies, the RegCM4 could simulate the Tibetan anticyclone and the direction of the tropical easterly jet reasonably well at 200 hPa. The projected temperature changes in 2070–2099 relative to 1976–2005 for GFDL-ESM2M show increased warming compared to RegCM4. The projected patterns at the end of 21st century shows an increase in precipitation over the Indian Peninsula and the Western Ghats. The possibilities of excessive precipitation include increased southwesterly flow in the wet period and the effect of model bias on climate change. However, the spatial patterns of precipitation are decreased in intensity and magnitude as the monsoon approaches the foothills of the Himalayas. The RegCM4-projected dry conditions over northeastern India are possibly related to the anomalous anticyclonic circulations in both scenarios.

  11. CNPC and CAS Sign Technological Cooperation Agreement

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ On August 16, 2006, China National Petroleum Corporation (CNPC) signed technological cooperation agreement with Chinese Academy of Sciences (CAS) at the Diaoyutai State Guesthouse in Beijing. Vice President of CNPC Zhou Jiping and Vice President of CAS Li Jiayang signed the agreement on behalf of both sides,marking a new era of unite brainstorm in petroleum technology. It will boost the development of petrochemical technology, especially the technology for the exploration and development of oil and gas field, engineering, oil refining and chemicals.

  12. Seat belt sign and its significance.

    Science.gov (United States)

    Agrawal, Amit; Inamadar, Praveenkumar Ishwarappa; Subrahmanyam, Bhattara Vishweswar

    2013-07-01

    Safety belts are the most important safety system in motor vehicles and when worn intend to prevent serious injuries. However, in unusual circumstances (high velocity motor vehicle collisions) these safety measures (seat belts) can be the source and cause of serious injuries. The seat belt syndrome was first described as early by Garrett and Braunste in but the term "seat belt sign" was discussed by Doersch and Dozier. Medical personnel's involved in emergency care of trauma patients should be aware of seat belt sign and there should a higher index of suspicion to rule out underlying organ injuries.

  13. Sign Language Benefits Tibetan Deaf-mutes

    Institute of Scientific and Technical Information of China (English)

    SUO QIONG; SUN WENZHEN

    2007-01-01

    @@ There are in Tibet Autonomous Region 190,000 disabled persons,including more than 30,000 who are deaf-mutes or are hearing impaired.In the Tibetan language,a word is often expressed with different signs.This poses a serious handicap for communication and exchanges among Tibetan deaf-mutes and their effort to participate in social activities.The ongoing research and development of a Tibetan sign language is expected to get rid of that handicap and allow Tibetan deaf-mutes to lead a normal life.

  14. A sequent calculus for signed interval logic

    DEFF Research Database (Denmark)

    Rasmussen, Thomas Marthedal

    2001-01-01

    We propose and discuss a complete sequent calculus formulation for Signed Interval Logic (SIL) with the chief purpose of improving proof support for SIL in practice. The main theoretical result is a simple characterization of the limit between decidability and undecidability of quantifier-free SIL....... We present a mechanization of SIL in the generic proof assistant Isabelle and consider techniques for automated reasoning. Many of the results and ideas of this report are also applicable to traditional (non-signed) interval logic and, hence, to Duration Calculus....

  15. A Short Note on Sign Changes

    Indian Academy of Sciences (India)

    Jaban Meher; Karam Deo Shankhadhar; G K Viswanadham

    2013-08-01

    In this paper, we present a quantitative result for the number of sign changes for the sequences $\\{a(n^j)\\}_{n≥ 1},j=2,3,4$ of the Fourier coefficients of normalized Hecke eigencusp forms for the full modular group $SL_2(\\mathbb{Z})$. We also prove a similar kind of quantitative result for the number of sign changes of the -exponents $c(p)$ ( vary over primes) of certain generalized modular functions for the congruence subgroup 0(), where is square-free.

  16. Signed graphs with two negative edges

    OpenAIRE

    Rollová, Edita; Schubert, Michael; Steffen, Eckhard

    2016-01-01

    The presented paper studies the flow number $F(G,\\sigma)$ of flow-admissible signed graphs $(G,\\sigma)$ with two negative edges. We restrict our study to cubic graphs, because for each non-cubic signed graph $(G,\\sigma)$ there is a set ${\\cal G}(G,\\sigma)$ of cubic graphs such that $F(G, \\sigma) \\leq \\min \\{F(H,\\sigma_H) : (H,\\sigma_H) \\in {\\cal G}(G)\\}$. We prove that $F(G,\\sigma) \\leq 6$ if $(G,\\sigma)$ contains a bridge and $F(G,\\sigma) \\leq 7$ in general. We prove better bounds, if there ...

  17. A bivariate chromatic polynomial for signed graphs

    CERN Document Server

    Beck, Matthias

    2012-01-01

    We study Dohmen--P\\"onitz--Tittmann's bivariate chromatic polynomial $c_\\Gamma(k,l)$ which counts all $(k+l)$-colorings of a graph $\\Gamma$ such that adjacent vertices get different colors if they are $\\le k$. Our first contribution is an extension of $c_\\Gamma(k,l)$ to signed graphs, for which we obtain an inclusion--exclusion formula and several special evaluations giving rise, e.g., to polynomials that encode balanced subgraphs. Our second goal is to derive combinatorial reciprocity theorems for $c_\\Gamma(k,l)$ and its signed-graph analogues, reminiscent of Stanley's reciprocity theorem linking chromatic polynomials to acyclic orientations.

  18. Cycles and Dynamics on Evolving Signed Digraphs

    CERN Document Server

    MacArthur, Ben D; Ma'ayan, Avi

    2009-01-01

    We consider a simple model which couples structural evolution of signed directed graphs to dynamic stability. The resulting systems self-organize to a complex dynamical state characterized by periods of stability punctuated by intermittent bursts of instability. By deriving analytical relationships between cyclic structure, cycle balance, and global stability in signed digraphs we show that the observed bursting dynamics result from the continual formation and breaking of transient directed cycles during the evolutionary process. At equilibrium bursts of instability develop heavy-tailed statistics suggesting a possible self-organized critical state.

  19. Elucidating the sign problem through noise distributions

    CERN Document Server

    Nicholson, Amy N; Kaplan, David B

    2012-01-01

    Due to the presence of light pions in the theory, lattice QCD at finite densities suffers from issues with noise in both grand canonical and canonical formulations. We study two different formulations of the Nambu-Jona-Lasinio model reduced to 2+1 dimensions at large N, where N is the number of flavors. At finite chemical potential one formulation has a severe sign problem and a fermion correlator which displays a broad probability distribution with small mean. In the other we find no sign problem and a distribution amenable to the cumulant expansion techniques developed in earlier work.

  20. Adapting the "Assessing British Sign Language Development: Receptive Skills Test" into American Sign Language

    Science.gov (United States)

    Enns, Charlotte J.; Herman, Rosalind C.

    2011-01-01

    Signed languages continue to be a key element of deaf education programs that incorporate a bilingual approach to teaching and learning. In order to monitor the success of bilingual deaf education programs, and in particular to monitor the progress of children acquiring signed language, it is essential to develop an assessment tool of signed…

  1. Spoken Language Activation Alters Subsequent Sign Language Activation in L2 Learners of American Sign Language.

    Science.gov (United States)

    Williams, Joshua T; Newman, Sharlene D

    2017-02-01

    A large body of literature has characterized unimodal monolingual and bilingual lexicons and how neighborhood density affects lexical access; however there have been relatively fewer studies that generalize these findings to bimodal (M2) second language (L2) learners of sign languages. The goal of the current study was to investigate parallel language activation in M2L2 learners of sign language and to characterize the influence of spoken language and sign language neighborhood density on the activation of ASL signs. A priming paradigm was used in which the neighbors of the sign target were activated with a spoken English word and compared the activation of the targets in sparse and dense neighborhoods. Neighborhood density effects in auditory primed lexical decision task were then compared to previous reports of native deaf signers who were only processing sign language. Results indicated reversed neighborhood density effects in M2L2 learners relative to those in deaf signers such that there were inhibitory effects of handshape density and facilitatory effects of location density. Additionally, increased inhibition for signs in dense handshape neighborhoods was greater for high proficiency L2 learners. These findings support recent models of the hearing bimodal bilingual lexicon, which posit lateral links between spoken language and sign language lexical representations.

  2. Adaptation of a Vocabulary Test from British Sign Language to American Sign Language

    Science.gov (United States)

    Mann, Wolfgang; Roy, Penny; Morgan, Gary

    2016-01-01

    This study describes the adaptation process of a vocabulary knowledge test for British Sign Language (BSL) into American Sign Language (ASL) and presents results from the first round of pilot testing with 20 deaf native ASL signers. The web-based test assesses the strength of deaf children's vocabulary knowledge by means of different mappings of…

  3. Approaching Sign Language Test Construction: Adaptation of the German Sign Language Receptive Skills Test

    Science.gov (United States)

    Haug, Tobias

    2011-01-01

    There is a current need for reliable and valid test instruments in different countries in order to monitor deaf children's sign language acquisition. However, very few tests are commercially available that offer strong evidence for their psychometric properties. A German Sign Language (DGS) test focusing on linguistic structures that are acquired…

  4. The Use of Sign Language Pronouns by Native-Signing Children with Autism

    Science.gov (United States)

    Shield, Aaron; Meier, Richard P.; Tager-Flusberg, Helen

    2015-01-01

    We report the first study on pronoun use by an under-studied research population, children with autism spectrum disorder (ASD) exposed to American Sign Language from birth by their deaf parents. Personal pronouns cause difficulties for hearing children with ASD, who sometimes reverse or avoid them. Unlike speech pronouns, sign pronouns are…

  5. Signs of Resistance: Peer Learning of Sign Languages within "Oral" Schools for the Deaf

    Science.gov (United States)

    Anglin-Jaffe, Hannah

    2013-01-01

    This article explores the role of the Deaf child as peer educator. In schools where sign languages were banned, Deaf children became the educators of their Deaf peers in a number of contexts worldwide. This paper analyses how this peer education of sign language worked in context by drawing on two examples from boarding schools for the deaf in…

  6. Tratamiento de la amnistía para graves violaciones de derechos humanos en los regímenes constitucionales de España, Chile y Perú

    OpenAIRE

    Rodríguez Gómez, Edgardo

    2009-01-01

    Durante la segunda mitad del siglo anterior e inicios del actual, una buena parte de los países iberoamericanos ha experimentado variados procesos de salida de regímenes autocráticos hacia regímenes democráticos. En los denominados procesos de transición a la democracia, los actores políticos encargados de diseñar el nuevo cauce institucional que deje en el pasado los postulados autoritarios y tradicionales del periodo previo suelen adoptar medidas que tienden al objetivo inmediato de una ref...

  7. Measuring the balance of signed networks and its application to sign prediction

    Science.gov (United States)

    Singh, Ranveer; Adhikari, Bibhas

    2017-06-01

    We propose a parametrized walk-based measure for the lack of balance in signed networks inspired by the Katz measure of similarity of two vertices in a network. We show that the performance of the proposed measure is marginally better than a recently proposed walk-based measure of the lack of balance for an undirected version of the real-world signed networks: Epinions, Slashdot and WikiElection. The proposed measure can be used to distinguish signed social networks on the basis of their degree of lack of balance. We also establish that cycles of shorter lengths can predict the sign of an edge in these signed networks better than the longer cycles by using the Katz prediction rule.

  8. The sign language skills classroom observation: a process for describing sign language proficiency in classroom settings.

    Science.gov (United States)

    Reeves, J B; Newell, W; Holcomb, B R; Stinson, M

    2000-10-01

    In collaboration with teachers and students at the National Technical Institute for the Deaf (NTID), the Sign Language Skills Classroom Observation (SLSCO) was designed to provide feedback to teachers on their sign language communication skills in the classroom. In the present article, the impetus and rationale for development of the SLSCO is discussed. Previous studies related to classroom signing and observation methodology are reviewed. The procedure for developing the SLSCO is then described. This procedure included (a) interviews with faculty and students at NTID, (b) identification of linguistic features of sign language important for conveying content to deaf students, (c) development of forms for recording observations of classroom signing, (d) analysis of use of the forms, (e) development of a protocol for conducting the SLSCO, and (f) piloting of the SLSCO in classrooms. The results of use of the SLSCO with NTID faculty during a trial year are summarized.

  9. Sign vocabulary in deaf toddlers exposed to sign language since birth.

    Science.gov (United States)

    Rinaldi, Pasquale; Caselli, Maria Cristina; Di Renzo, Alessio; Gulli, Tiziana; Volterra, Virginia

    2014-07-01

    Lexical comprehension and production is directly evaluated for the first time in deaf signing children below the age of 3 years. A Picture Naming Task was administered to 8 deaf signing toddlers (aged 2-3 years) who were exposed to Sign Language since birth. Results were compared with data of hearing speaking controls. In both deaf and hearing children, comprehension was significantly higher than production. The deaf group provided a significantly lower number of correct responses in production than did the hearing controls, whereas in comprehension, the 2 groups did not differ. Difficulty and ease of items in comprehension and production was similar for signing deaf children and hearing speaking children, showing that, despite size differences, semantic development followed similar paths. For signing children, predicates production appears easier than nominals production compared with hearing children acquiring spoken language. Findings take into account differences in input modalities and language structures.

  10. SignsWorld; Deeping Into the Silence World and Hearing Its Signs (State of the Art)

    CERN Document Server

    Riad, A M; Shohieb, Samaa M; Asem, A S

    2012-01-01

    Automatic speech processing systems are employed more and more often in real environments. Although the underlying speech technology is mostly language independent, differences between languages with respect to their structure and grammar have substantial effect on the recognition systems performance. In this paper, we present a review of the latest developments in the sign language recognition research in general and in the Arabic sign language (ArSL) in specific. This paper also presents a general framework for improving the deaf community communication with the hearing people that is called SignsWorld. The overall goal of the SignsWorld project is to develop a vision-based technology for recognizing and translating continuous Arabic sign language ArSL.

  11. Error Bounds for the Sign Function

    CERN Document Server

    Frommer, Andreas; Lippert, Thomas; Rittich, H

    2011-01-01

    The Overlap operator fulfills the Ginsparg-Wilson relation exactly and therefore represents an optimal discretization of the QCD Dirac operator with respect to chiral symmetry. When computing propagators or in HMC simulations, where one has to invert the overlap operator using some iterative solver, one has to approxomate the action of the sign function of the (symmetrized) Wilson fermion matrix Q on a vector b in each iteration. This is usually done iteratively using a "primary" Lanczos iteration. In this process, it is very important to have good stopping criteria which allow to reliably assess the quality of the approximation to the action of the sign function computed so far. In this work we show how to cheaply recover a secondary Lanczos process, starting at an arbitrary Lanczos vector of the primary process and how to use this secondary process to efficiently obtain computable error estimates and error bounds for the Lanczos approximations to sign(Q)b, where the sign function is approximated by the Zolo...

  12. Hemoptysis with a classical radiological sign

    Directory of Open Access Journals (Sweden)

    Sameer Gulati

    2011-01-01

    Full Text Available There can be various causes for hemoptysis. We present here a case of hemoptysis in which the chest X-ray helped us to arrive at the diagnosis because of a classical sign. This highlights the need of identifying this finding for prompt recognition of the cause of hemoptysis.

  13. A Discrete Dynamical Model of Signed Partitions

    Directory of Open Access Journals (Sweden)

    G. Chiaselotti

    2013-01-01

    Full Text Available We use a discrete dynamical model with three evolution rules in order to analyze the structure of a partially ordered set of signed integer partitions whose main properties are actually not known. This model is related to the study of some extremal combinatorial sum problems.

  14. CDC Vital Signs: Preventing Teen Pregnancy

    Science.gov (United States)

    ... 0:60 seconds] On Other Web Sites MedlinePlus - Teenage Pregnancy MedlinePlus - Birth Control The Doctor's Channel: CDC Vital Signs Long Acting Reversible Contraception [VIDEO - 3:30 minutes] Top of ... HHS/Open USA.gov Top

  15. Malta to sign MOU with CERN

    CERN Multimedia

    2008-01-01

    In what can be described as a historic moment for Malta's scientific sector, Prime Minister Lawrence Gonzi will today sign a memorandum of understanding with CERN that will start off a long-term participation project for Maltese engineers and scientists in research and innovation projects.

  16. Discourse Cohesion in Sign and Speech.

    Science.gov (United States)

    Morgan, Gary

    2000-01-01

    Describes the development of discourse cohesion in bilingual children through an analysis of narrative discourses produced by hearing children of deaf parents (HCDP) in both British Sign Language (BSL) and spoken English. Reference mechanisms in both languages are described in the context of recent work on narrative and discourse organization…

  17. Looking for Signs of Alzheimer's Disease

    Science.gov (United States)

    Hodgson, Lynne Gershenson; Cutler, Stephen J.

    2003-01-01

    This study examined the correlates of symptom-seeking behavior for Alzheimer's disease (AD) among middle-aged persons. Symptom seeking, the tendency to search for signs of disease, is one manifestation of an individual's concern about developing AD. The data were obtained from a survey of two subsamples of 40-60 year old adults: 1) 108 adult…

  18. Exploring Power & Ethnocentrism in Sign language Translation

    Science.gov (United States)

    Leneham, Marcel

    2007-01-01

    This article demonstrates that theories intended to prevent ethnocentric influence for one pair of languages may, in fact, be the catalyst for the phenomenon it purports to prevent in another pair. While it explores the issue in relation to sign language translation, the article raises the question of whether the findings can be extrapolated to…

  19. Vital Signs-Preventing Norovirus Outbreaks

    Centers for Disease Control (CDC) Podcasts

    2014-06-03

    This podcast is based on the June 2014 CDC Vital Signs report. Norovirus infects about 20 million Americans each year. Learn how to protect yourself and your family from this very contagious, potentially serious illness.  Created: 6/3/2014 by National Center for Immunization and Respiratory Diseases (NCIRD).   Date Released: 6/3/2014.

  20. Aluminium overhead highway traffic sign structures

    NARCIS (Netherlands)

    Courage, W.M.G.; Soetens, F.; Noordzij, R.; Drabbels, J.

    1998-01-01

    This paper deals with the design and manufacturing of aluminium overhead sign structures. These gantries are built up by using two X-shaped column frames connected by a triangular space frame girder. Slenderness and a low solidity ratio were objectives in the architectonic design. Braces and main ch

  1. Conceptual representation of actions in sign language

    NARCIS (Netherlands)

    Dobel, Christian; Enriquez-Geppert, Stefanie; Hummert, Marja; Zwitserlood, Pienie; Bölte, Jens

    2011-01-01

    The idea that knowledge of events entails a universal spatial component, that is conceiving agents left of patients, was put to test by investigating native users of German sign language and native users of spoken German. Participants heard or saw event descriptions and had to illustrate the meaning

  2. Vital Signs-Motor Vehicle Crash Injuries

    Centers for Disease Control (CDC) Podcasts

    2014-10-07

    This podcast is based on the October 2014 CDC Vital Signs report. Motor vehicle crashes are costly and preventable. Learn what can be done to help prevent motor vehicle injuries.  Created: 10/7/2014 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 10/7/2014.

  3. Battlefield triage life signs detection techniques

    Science.gov (United States)

    Boric-Lubecke, Olga; Lin, Jenshan; Park, Byung-Kwon; Li, Changzhi; Massagram, Wansuree; Lubecke, Victor M.; Host-Madsen, Anders

    2008-04-01

    Getting to wounded soldiers on the battlefield is a precarious task, and medics have a very high casualty rate. It is therefore a vital importance to prioritize which soldiers to attend to first. The first step is to detect life signs - if a soldier is dead or alive, and prioritize recovery of live soldiers. The second step is to obtain vital signs from live soldiers, and use this to prioritize which are in most urgent need of attention. Our team at Kai Sensors, University of Hawaii and University of Florida is developing Doppler radar heart sensing technology that provides the means to detect life signs, respiration and/or heart beat, at a distance, even for subjects lying motionless, e.g., unconscious subjects, wearing body armor, and hidden from direct view. Since this technology can deliver heart rate information with high accuracy, it may also enable the assessment of a subject's physiological and psychological state based on heart rate variability (HRV) analysis. Thus, the degree of a subject's injury may also be determined. The software and hardware developments and challenges for life signs detection and monitoring for battlefield triage will be discussed, including heart signal detection from all four sides of the human body, detection in the presence of body armor, and the feasibility of HRV parameter extraction.

  4. CDC Vital Signs: Cervical Cancer is Preventable

    Science.gov (United States)

    ... HPV vaccine can reduce risk of cervical cancer. HPV causes most cervical cancers. Only 1 in 3 girls and 1 in ... Signs – Cervical Cancer [PSA - 0:60 seconds] Cervical Cancer Preteen and Teen Vaccines Human Papillomavirus (HPV)-Associated Cancers What Should I Know About ...

  5. Mobile Sign Language Learning Outside the Classroom

    Science.gov (United States)

    Weaver, Kimberly A.; Starner, Thad

    2012-01-01

    The majority of deaf children in the United States are born to hearing parents with limited prior exposure to American Sign Language (ASL). Our research involves creating and validating a mobile language tool called SMARTSign. The goal is to help hearing parents learn ASL in a way that fits seamlessly into their daily routine. (Contains 3 figures.)

  6. The Sign Language Situation in Mali

    Science.gov (United States)

    Nyst, Victoria

    2015-01-01

    This article gives a first overview of the sign language situation in Mali and its capital, Bamako, located in the West African Sahel. Mali is a highly multilingual country with a significant incidence of deafness, for which meningitis appears to be the main cause, coupled with limited access to adequate health care. In comparison to neighboring…

  7. Syntactic priming in American Sign Language.

    Science.gov (United States)

    Hall, Matthew L; Ferreira, Victor S; Mayberry, Rachel I

    2015-01-01

    Psycholinguistic studies of sign language processing provide valuable opportunities to assess whether language phenomena, which are primarily studied in spoken language, are fundamentally shaped by peripheral biology. For example, we know that when given a choice between two syntactically permissible ways to express the same proposition, speakers tend to choose structures that were recently used, a phenomenon known as syntactic priming. Here, we report two experiments testing syntactic priming of a noun phrase construction in American Sign Language (ASL). Experiment 1 shows that second language (L2) signers with normal hearing exhibit syntactic priming in ASL and that priming is stronger when the head noun is repeated between prime and target (the lexical boost effect). Experiment 2 shows that syntactic priming is equally strong among deaf native L1 signers, deaf late L1 learners, and hearing L2 signers. Experiment 2 also tested for, but did not find evidence of, phonological or semantic boosts to syntactic priming in ASL. These results show that despite the profound differences between spoken and signed languages in terms of how they are produced and perceived, the psychological representation of sentence structure (as assessed by syntactic priming) operates similarly in sign and speech.

  8. Signs of Drug Use and Addiction

    Science.gov (United States)

    ... Use and Addiction Signs of Drug Use and Addiction Listen PDF: EasyToRead_WhatIsAddiction_Final_012017.pdf People ... English Español "I feel so helpless against his addiction." ©istock.com/ Antonio_Diaz Matt's brother Stephen is ...

  9. SIGN LANGUAGE IN ASTRONOMY AND SPACE SCIENCES

    Directory of Open Access Journals (Sweden)

    J. Cova

    2009-01-01

    Full Text Available Teaching science to school children with hearing de ciency and impairment can be a rewarding and valuable experience for both teacher and student, and necessary to society as a whole in order to reduce the discriminative policies in the formal educational system. The one most important obstacle to the teaching of science to students with hearing de ciency and impairments is the lack of vocabulary in sign language to express the precise concepts encountered in scienti c endeavor. In a collaborative project between Centro de Investigaciones de Astronom a \\Francisco J. Duarte" (CIDA, Universidad Pedag gica Experimental Libertador-Instituto Pedag gico de Matur n (UPEL-IPM and Unidad Educativa Especial Bolivariana de Matur n (UEEBM initiated in 2006, we have attempted to ll this gap by developing signs for astronomy and space sciences terminology. During two three-day workshops carried out at CIDA in M rida in July 2006 and UPEL-IPM in Matur n in March 2007 a total of 112 concepts of astronomy and space sciences were coined in sign language using an interactive method which we describe in the text. The immediate goal of the project is to incorporate these terms into Venezuelan Sign Language (LSV.

  10. The Magic Sign: Acids, Bases, and Indicators.

    Science.gov (United States)

    Phillips, Donald B.

    1986-01-01

    Presents an approach that is used to introduce elementary and junior high students to a series of activities that will provide concrete experiences with acids, bases, and indicators. Provides instructions and listings of needed solutions and materials for developing this "magic sign" device. Includes background information and several…

  11. DC-SIGN:Binding receptor for HCV?

    Institute of Scientific and Technical Information of China (English)

    Zhi-Hua Feng; Quan-Chu Wang; Qing-He Nie; Zhan-Sheng Jia; Yong-Xin Zhou

    2004-01-01

    DC-SIGN, a dendritic Cell-specific adhesion receptor and a type Ⅱ transmembrane mannose-binding C-type lectin, is very important in the function of DC, both in mediating naive T cell interactions through ICAM-3 and as a rolling receptor that mediates the DC-specific ICAM-2-dependent migration processes. It can be used by viral and bacterial pathogens including Human Immunodeficiency Virus (HIV), HCV, Ebola Virus, CMV and Mycobacterium tuberculosis to facilitate infection. Both DC-SIGN and DC-SIGNR can act either in cis,by concentrating virus on target cells, or in trans, by transmission of bound virus to a target cell expressing appropropriate entry receptors. Recent work showed that DC-SIGN are highaffinity binding receptors for HCV. Besides playing a role in entry into DC, HCV E2 interaction with DC-SIGN might also be detrimental for the interaction of DC with T cells during antigen presentation. The clinical strategies that target DCSIGN may be successful in restricting HCV dissemination and pathogenesis as well as directing the migration of DCs to manipulate appropriate immune responses in autoimmunity and tumorigenic situations.

  12. Decompositions of Revised Monotone Signed Fuzzy Measures

    Institute of Scientific and Technical Information of China (English)

    张强; 刘克

    2003-01-01

    The concept of fuzzy measure was introduced by Sugeno in 1974. A notion of signed fuzzy measure is introduced in this paper, and its elementary properties are briefly discussed. An analogue of Hahn decomposition theorem is established under the null-null-additive condition. A version of the Jordan decomposition theorem is proved under the null-additive condition.

  13. American Sign Language Curricula: A Review

    Science.gov (United States)

    Rosen, Russell S.

    2010-01-01

    There is an exponential growth in the number of schools that offer American Sign Language (ASL) for foreign language credit and the different ASL curricula that were published. This study analyzes different curricula in its assumptions regarding language, learning, and teaching of second languages. It is found that curricula vary in their…

  14. knowledge about obstetric danger signs among preg

    African Journals Online (AJOL)

    user

    about knowledge level of pregnant women on obstetric danger signs. The objective of this ... deficiencies in awareness should be addressed through maternal and child health services by designing an appro- ..... demographic, cultural, and health interventions as well as ... Baby Package: Implementing Safe Motherhood.

  15. ASL or Contact Signing: Issues of Judgment.

    Science.gov (United States)

    Lucas, Ceil; Valli, Clayton

    1991-01-01

    Reports on one aspect of an ongoing study of language contact in the American deaf community. The ultimate goal of the study is a linguistic description of contact signing and a reexamination of claims that it is a pidgin. Patterns of language use are reviewed and the role of demographic information in judgments is examined. (29 references) (GLR)

  16. Warning signs and symptoms of heart disease

    Science.gov (United States)

    ... veins that go from the lungs to the heart. Fluid leaks into the lungs and causes shortness of ... another sign of a heart problem. When your heart doesn't work as ... legs. This causes fluid to build up in your tissues. You may ...

  17. Cooperation Agreement Signed Between CPAFFC and HSF

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    <正>An agreement on cooperation between theCPAFFC and the Hanns Seidel Foundation was signed in Beijing on October 24, 2003. The agreement sets forth the framework of cooperation between the two sides and concrete forms and programmes of cooperation. The two sides will regularly carry out exchanges between parlia-

  18. It’s all about safety signs!

    CERN Multimedia

    2013-01-01

    Their first occurrence may date back to the Egyptian hieroglyphs, but today they can be found everywhere: on our clothes labels as care labels, in train stations and airports to guide us, during the Olympics to identify various sports, on our dashboards, etc.   Safety wise, they are used to indicate a danger, a prohibition, an obligation, a safety exit, firefighting equipment, etc. The HSE Unit has decided to update the 150 safety signs used on the CERN site and, to correspond with this, recently published a Safety Guideline GS-1-0-1, available on the Safety Unit website. The Guideline contains more than 150 safety signs as well as diverse information regarding the meaning of the signs, their location and how to use them. The Guideline will shortly be completed with a new Safety Rule that will replace the former Security Code A3, “Safety colours and safety signs”. Please be informed that you also have the option to create new safety signs, provided that you first g...

  19. Clever Cars Can Read Road Signs

    Institute of Scientific and Technical Information of China (English)

    Duncan Graham-Rowe; 张高慧

    2004-01-01

    @@ The plaintive① plea to the traffic cop② is the same the world over: "Sorry officer, I didn't know I was speeding." But drivers may soon have to come up with a better excuse. A new electronic driver's assistant will detect road signs and warn drivers not to ignore them.

  20. Sign Language in Astronomy and Space Sciences

    Science.gov (United States)

    Cova, J.; Movilio, V.; Gómez, Y.; Gutiérrez, F.; García, R.; Moreno, H.; González, F.; Díaz, J.; Villarroel, C.; Abreu, E.; Aparicio, D.; Cárdenas, J.; Casneiro, L.; Castillo, N.; Contreras, D.; La Verde, N.; Maita, M.; Martínez, A.; Villahermosa, J.; Quintero, A.

    2009-05-01

    Teaching science to school children with hearing deficiency and impairment can be a rewarding and valuable experience for both teacher and student, and necessary to society as a whole in order to reduce the discriminative policies in the formal educational system. The one most important obstacle to the teaching of science to students with hearing deficiency and impairments is the lack of vocabulary in sign language to express the precise concepts encountered in scientific endeavor. In a collaborative project between Centro de Investigaciones de Astronomía ``Francisco J. Duarte'' (CIDA), Universidad Pedagógica Experimental Libertador-Instituto Pedagógico de Maturín (UPEL-IPM) and Unidad Educativa Especial Bolivariana de Maturín (UEEBM) initiated in 2006, we have attempted to fill this gap by developing signs for astronomy and space sciences terminology. During two three-day workshops carried out at CIDA in Mérida in July 2006 and UPEL-IPM in Maturín in March 2007 a total of 112 concepts of astronomy and space sciences were coined in sign language using an interactive method which we describe in the text. The immediate goal of the project is to incorporate these terms into Venezuelan Sign Language (LSV).

  1. The Minus Sign in Faraday's Law Revisited

    Science.gov (United States)

    O'Sullivan, Colm; Hurley, Donal

    2013-01-01

    By introducing the mathematical concept of orientation, the significance of the minus sign in Faraday's law may be made clear to students with some knowledge of vector calculus. For many students, however, the traditional approach of treating the law as a relationship between positive scalars and of relying on Lenz's law to provide the information…

  2. Signs of Cocaine Abuse and Addiction

    Science.gov (United States)

    ... Use and Addiction Signs of Cocaine Use and Addiction Listen ©istock.com/ AntonioGuillern After the "high" of the cocaine wears off, you can "crash" and feel tired and sad for days. You also get a strong craving to take the drug again to try to ...

  3. 47 CFR 74.791 - Digital call signs.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Digital call signs. 74.791 Section 74.791... Booster Stations § 74.791 Digital call signs. (a) Digital low power stations. Call signs for digital low... −D. (b) Digital television translator stations. Call signs for digital television translator...

  4. SignMT: An Alternative Language Learning Tool

    Science.gov (United States)

    Ditcharoen, Nadh; Naruedomkul, Kanlaya; Cercone, Nick

    2010-01-01

    Learning a second language is very difficult, especially, for the disabled; the disability may be a barrier to learn and to utilize information written in text form. We present the SignMT, Thai sign to Thai machine translation system, which is able to translate from Thai sign language into Thai text. In the translation process, SignMT takes into…

  5. Sign Language with Babies: What Difference Does It Make?

    Science.gov (United States)

    Barnes, Susan Kubic

    2010-01-01

    Teaching sign language--to deaf or other children with special needs or to hearing children with hard-of-hearing family members--is not new. Teaching sign language to typically developing children has become increasingly popular since the publication of "Baby Signs"[R] (Goodwyn & Acredolo, 1996), now in its third edition. Attention to signing with…

  6. 10 CFR 431.202 - Definitions concerning illuminated exit signs.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Definitions concerning illuminated exit signs. 431.202... COMMERCIAL AND INDUSTRIAL EQUIPMENT Illuminated Exit Signs § 431.202 Definitions concerning illuminated exit signs. Basic model means, with respect to illuminated exit signs, all units of a given type...

  7. Further Results on the Nullity of Signed Graphs

    Directory of Open Access Journals (Sweden)

    Yu Liu

    2014-01-01

    Full Text Available The nullity of a graph is the multiplicity of the eigenvalue zero in its spectrum. A signed graph is a graph with a sign attached to each of its edges. In this paper, we apply the coefficient theorem on the characteristic polynomial of a signed graph and give two formulae on the nullity of signed graphs with cut-points. As applications of the above results, we investigate the nullity of the bicyclic signed graph Γ∞p,q,l, obtain the nullity set of unbalanced bicyclic signed graphs, and thus determine the nullity set of bicyclic signed graphs.

  8. Case report: Dot-in-circle sign - An MRI and USG sign for "Madura foot"

    Directory of Open Access Journals (Sweden)

    Anitha Sen

    2011-01-01

    Full Text Available Mycetoma is a chronic granulomatous disease that is more common in tropical than in temperate regions. Early diagnosis is important due to the therapeutic implications. Although biopsy and microbiological culture provide definitive diagnosis, they are time-consuming procedures and may not be able to provide a definite diagnosis in cases of fastidious organisms. The "dot-in-circle" sign has recently been proposed as a highly specific magnetic resonance imaging (MRI and ultrasonography (USG sign of mycetoma, which may allow a noninvasive as well as early diagnosis. We present a case of histologically proven mycetoma that demonstrated this sign.

  9. Statistical Sign Language Machine Translation: from English written text to American Sign Language Gloss

    CERN Document Server

    Othman, Achraf

    2011-01-01

    This works aims to design a statistical machine translation from English text to American Sign Language (ASL). The system is based on Moses tool with some modifications and the results are synthesized through a 3D avatar for interpretation. First, we translate the input text to gloss, a written form of ASL. Second, we pass the output to the WebSign Plug-in to play the sign. Contributions of this work are the use of a new couple of language English/ASL and an improvement of statistical machine translation based on string matching thanks to Jaro-distance.

  10. Phonological Development in Hearing Learners of a Sign Language: The Influence of Phonological Parameters, Sign Complexity, and Iconicity

    Science.gov (United States)

    Ortega, Gerardo; Morgan, Gary

    2015-01-01

    The present study implemented a sign-repetition task at two points in time to hearing adult learners of British Sign Language and explored how each phonological parameter, sign complexity, and iconicity affected sign production over an 11-week (22-hour) instructional period. The results show that training improves articulation accuracy and that…

  11. Estudio de viabilidad de un campo exploratorio en África central según diferentes regímenes fiscales

    OpenAIRE

    Díaz del Río Redondo, Álvaro

    2013-01-01

    El objetivo del presente proyecto consiste en analizar la viabilidad de un campo de E&P (Exploración y Producción) de hidrocarburos situado en Gabón en función de diferentes regímenes fiscales con el fin de estudiar el reparto de la renta entre el gobierno y la compañía petrolífera. Tras estudiar los parámetros técnicos del proyecto y confirmar su viabilidad desde un punto de vista puramente técnico, en la segunda parte del estudio se analiza para un mismo campo el impacto que tiene la variac...

  12. Analizando los regímenes de violación en la intersección entre la guerra y la paz en el Perú

    OpenAIRE

    Boesten, Jelke

    2011-01-01

    Utilizando el conflicto político en el Perú (1980-2000) como estudio de caso, en este trabajo sostengo que el hecho de entender la violación como arma de guerra oculta otros regímenes de violación que tuvieron lugar durante el conflicto armado interno y que no encajan necesariamente con esta definición.Estas prácticas incluyen la violación como consumo, la violación oportunista, la violación perpetrada por vecinos o miembros de la familia, la prostitución forzada y la violación en el periodo ...

  13. Cuestión social y regímenes militares. Argentina y Chile durante los años setenta

    Directory of Open Access Journals (Sweden)

    Gabriela Gomes

    2015-01-01

    Full Text Available En este artículo se analizan las políticas sociales destinadas a la búsqueda del consenso que llevaron adelante la Secretaría de Estado de Promoción y Asistencia a la Comunidad del Ministerio de Bienestar Social durante la “Revolución Argentina” (1966-1973 y la Dirección de Organizaciones Civiles y el Ministerio del Interior durante la dictadura chilena (1973-1988. El abordaje propuesto apunta a complejizar la noción de Estado burocrático autoritario, puesto que se considera como hipótesis que ambos regímenes no solo se dedicaron a reprimir las actividades políticas de los sectores populares, sino que buscaron reorganizarlos bajo nuevas coordenadas sociales.

  14. A study of the tactual reception of sign language.

    Science.gov (United States)

    Reed, C M; Delhorne, L A; Durlach, N I; Fischer, S D

    1995-04-01

    One of the natural methods of tactual communication in common use among individuals who are both deaf and blind is the tactual reception of sign language. In this method, the receiver (who is deaf-blind) places a hand (or hands) on the dominant (or both) hand(s) of the signer in order to receive, through the tactual sense, the various formational properties associated with signs. In the study reported here, 10 experienced deaf-blind users of either American Sign Language (ASL) or Pidgin Sign English (PSE) participated in experiments to determine their ability to receive signed materials including isolated signs and sentences. A set of 122 isolated signs was received with an average accuracy of 87% correct. The most frequent type of error made in identifying isolated signs was related to misperception of individual phonological components of signs. For presentation of signed sentences (translations of the English CID sentences into ASL or PSE), the performance of individual subjects ranged from 60-85% correct reception of key signs. Performance on sentences was relatively independent of rate of presentation in signs/sec, which covered a range of roughly 1 to 3 signs/sec. Sentence errors were accounted for primarily by deletions and phonological and semantic/syntactic substitutions. Experimental results are discussed in terms of differences in performance for isolated signs and sentences, differences in error patterns for the ASL and PSE groups, and communication rates relative to visual reception of sign language and other natural methods of tactual communication.

  15. Study of seasonal climatology and interannual variability over India and its subregions using a regional climate model (RegCM3)

    Science.gov (United States)

    Maharana, P.; Dimri, A. P.

    2014-06-01

    The temporal and spatial variability of the various meteorological parameters over India and its different subregions is high. The Indian subcontinent is surrounded by the complex Himalayan topography in north and the vast oceans in the east, west and south. Such distributions have dominant influence over its climate and thus make the study more complex and challenging. In the present study, the climatology and interannual variability of basic meteorological fields over India and its six homogeneous monsoon subregions (as defined by Indian Institute of Tropical Meteorology (IITM) for all the four meteorological seasons) are analysed using the Regional Climate Model Version 3 (RegCM3). A 22-year (1980-2001) simulation with RegCM3 is carried out to develop such understanding. The National Centre for Environmental Prediction/National Centre for Atmospheric Research, US (NCEP-NCAR) reanalysis 2 (NNRP2) is used as the initial and lateral boundary conditions. The main seasonal features and their variability are represented in model simulation. The temporal variation of precipitation, i.e., the mean annual cycle, is captured over complete India and its homogenous monsoon subregions. The model captured the contribution of seasonal precipitation to the total annual precipitation over India. The model showed variation in the precipitation contribution for some subregions to the total and seasonal precipitation over India. The correlation coefficient (CC) and difference between the coefficient of variation between model fields and the corresponding observations in percentage (COV) is calculated and compared. In most of the cases, the model could represent the magnitude but not the variability. The model processes are found to be more important than in the corresponding observations defining the variability. The model performs quite well over India in capturing the climatology and the meteorological process. The model shows good skills over the relevant subregions during a

  16. A new method for the investigation of mercury redox chemistry in natural waters utilizing deflatable Teflon[reg] bags and additions of isotopically labeled mercury

    Energy Technology Data Exchange (ETDEWEB)

    Whalin, Lindsay M. [Chesapeake Biological Laboratory, University of Maryland, Solomons, MD 20688 (United States); Mason, Robert P. [Chesapeake Biological Laboratory, University of Maryland, Solomons, MD 20688 (United States)]. E-mail: robert.mason@uconn.edu

    2006-02-03

    The toxicity and behavior of mercury (Hg) varies greatly between its chemical species, yet the mechanisms which control the redox chemistry of Hg in natural waters are still poorly understood. Previous studies have identified these processes and compared the Hg redox chemistry between water types but have been hampered by errors associated primarily with the type of reaction vessels utilized, and the inability of the methods to simultaneously measure oxidation and reduction. Presented here are the results of experiments which demonstrate the validity of a new method that addresses both these issues through the design and use of a new reaction vessel, a 5 L PFA Teflon[reg] incubation bag, and by the addition of isotopically labeled inorganic Hg species (both Hg{sup II} and Hg{sup 0}). The method development showed that mm thick FEP Teflon[reg] is permeable to Hg{sup 0}, and therefore unsuitable. Application of this method showed that both oxidation and reduction occurred simultaneously in natural waters exposed to ambient sunlight and that the rate of these transformations were of similar order (10{sup -3} to 10{sup -4} s{sup -1}). Given such reaction rates, the characteristic time to equilibrium is rapid, on the order of hours. The method is applicable for tracer studies, and the method was able to quantify rate constants of greater than 10{sup -5} s{sup -1}. Overall, this study suggests that the rates of reaction are faster than previously predicted primarily because previous studies did not account for the fact that both reactions are occurring simultaneously in natural waters.

  17. Projected changes in temperature and precipitation climatology of Central Asia CORDEX Region 8 by using RegCM4.3.5

    Science.gov (United States)

    Ozturk, Tugba; Turp, M. Tufan; Türkeş, Murat; Kurnaz, M. Levent

    2017-01-01

    This work investigated projected future changes in seasonal mean air temperature (°C) and precipitation (mm/day) climatology for the three periods of 2011-2040, 2041-2070, and 2071-2100, with respect to the control period of 1971-2000 for the Central Asia domain via regional climate model simulations. In order to investigate the projected changes in near future climate conditions, the Regional Climate Model, RegCM4.3.5 of the International Centre for Theoretical Physics (ICTP) was driven by two different CMIP5 global climate models. The HadGEM2-ES global climate model of the Met Office Hadley Centre and the MPI-ESM-MR global climate model of the Max Planck Institute for Meteorology were downscaled to 50 km for the Coordinated Regional Climate Downscaling Experiment (CORDEX) Region 8. We investigated the seasonal time-scale performance of RegCM4.3.5 in reproducing observed climatology over the domain of the Central Asia by using two different global climate model outputs. For the future climatology of the domain, the regional model projects relatively high warming in the warm season with a decrease in precipitation in almost all parts of the domain. A warming trend is notable, especially for the northern part of the domain during the cold season. The results of our study show that surface air temperatures in the region will increase between 3 °C and about 7 °C on average, according to the emission scenarios for the period of 2071-2100 with respect to past period of 1971-2000. Therefore, the projected warming and decrease in precipitation might adversely affect the ecological and socio-economic systems of this region, which is already a mostly arid and semi-arid environment.

  18. Study of seasonal climatology and interannual variability over India and its subregions using a regional climate model (RegCM3)

    Indian Academy of Sciences (India)

    P Maharana; A P Dimri

    2014-07-01

    The temporal and spatial variability of the various meteorological parameters over India and its different subregions is high. The Indian subcontinent is surrounded by the complex Himalayan topography in north and the vast oceans in the east, west and south. Such distributions have dominant influence over its climate and thus make the study more complex and challenging. In the present study, the climatology and interannual variability of basic meteorological fields over India and its six homogeneous monsoon subregions (as defined by Indian Institute of Tropical Meteorology (IITM) for all the four meteorological seasons) are analysed using the Regional Climate Model Version 3 (RegCM3). A 22-year (1980–2001) simulation with RegCM3 is carried out to develop such understanding. The National Centre for Environmental Prediction/National Centre for Atmospheric Research, US (NCEP-NCAR) reanalysis 2 (NNRP2) is used as the initial and lateral boundary conditions. The main seasonal features and their variability are represented in model simulation. The temporal variation of precipitation, i.e., the mean annual cycle, is captured over complete India and its homogenous monsoon subregions. The model captured the contribution of seasonal precipitation to the total annual precipitation over India. The model showed variation in the precipitation contribution for some subregions to the total and seasonal precipitation over India. The correlation coefficient (CC) and difference between the coefficient of variation between model fields and the corresponding observations in percentage (COV) is calculated and compared. In most of the cases, the model could represent the magnitude but not the variability. The model processes are found to be more important than in the corresponding observations defining the variability. The model performs quite well over India in capturing the climatology and the meteorological process. The model shows good skills over the relevant subregions during a

  19. Sign problem in finite density lattice QCD

    CERN Document Server

    Goy, V A; Boyda, D; Molochkov, A; Nakamura, A; Nikolaev, A; Zakharov, V

    2016-01-01

    The canonical approach, which was developed for solving the sign problem, may suffer from a new type of sign problem. In the canonical approach, the grand partition function is written as a fugacity expansion: $Z_G(\\mu,T) = \\sum_n Z_C(n,T) \\xi^n$, where $\\xi=\\exp(\\mu/T)$ is the fugacity, and $Z_C(n,T)$ are given as averages over a Monte Carlo update, $\\langle z_n\\rangle$. We show that the complex phase of $z_n$ is proportional to $n$ at each Monte Carlo step. Although $\\langle z_n\\rangle$ take real positive values, the values of $z_n$ fluctuate rapidly when $n$ is large, especially in the confinement phase, which gives a limit on $n$. We discuss possible remedies for this problem.

  20. Signs, Systems and Complexity of Transmedia Storytelling

    Directory of Open Access Journals (Sweden)

    Renira Rampazzo Gambarato

    2012-12-01

    Full Text Available This article addresses key concepts such as sign, system and complexity in order to approach transmedia storytelling and better understand its intricate nature. The theoretical framework chosen to investigate transmedia storytelling meanders is Semiotics by Charles Sanders Peirce (1839-1914 and General Systems Theory by Mario Bunge (1919-. The complexity of transmedia storytelling is not simply the one of the signs of the works included in a transmedia franchise. It also includes the complexity of the dispositions of users/consumers/players as interpreters of semiotic elements (e.g. characters, themes, environments, events and outcomes presented by transmedia products. It extends further to the complexity of social, cultural, economical and political constructs. The German transmedia narrative The Ultimate SuperHero-Blog by Stefan Gieren and Sofia’s Diary, a Portuguese multiplatform production by BeActive, are presented as examples of closed and open system transmedia storytelling respectively.