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Sample records for ilc intrinsic properties

  1. Investigation of DEPFET as vertex detector at ILC. Intrinsic properties, radiation hardness and alternative readout schemes

    Energy Technology Data Exchange (ETDEWEB)

    Rummel, Stefan

    2009-07-20

    The International Linear Collider (ILC) is supposed to be the next generation lepton collider. The detectors at ILC are intended to be precision instruments improving the performance in impact parameter (IP), momentum and energy resolution significantly compared to previous detectors at lepton colliders. To achieve this goal it is necessary to develop new detector technologies or pushing existing technologies to their technological edges. Regarding the Vertex detector (VTX) this implies challenges in resolution, material budget, power consumption and readout speed. A promising technology for the Vertex detector is the Depleted Field Effect Transistor (DEPFET). The DEPFET is a semiconductor device with in-pixel ampli cation integrated on a fully depleted bulk. This allows building detectors with intrinsically high SNR due to the large sensitive volume and the small input capacitance at the rst ampli er. To reach the ambitious performance goals it is important to understand its various features: clear performance, internal amplification, noise and radiation hardness. The intrinsic noise is analyzed, showing that the contribution of the DEPFET is below 50 e{sup -} at the required speed. Moreover it is possible to show that the internal ampli cation could be further improved to more than 1nA/e{sup -} using the standard DEPFET technology. The clear performance is investigated on matrix level utilizing a dedicated setup for single pixel testing which allows direct insight into the DEPFET operation, without the complexity of the full readout system. It is possible to show that a full clear could be achieved with a voltage pulse of 10 V. Furthermore a novel clear concept - the capacitive coupled clear gate - is demonstrated. The radiation hardness is studied with respect to the system performance utilizing various irradiations with ionizing and non ionizing particles. The impact on the bulk as well as the interface damage is investigated. Up to now the readout is performed

  2. ILC Higgs White Paper

    CERN Document Server

    Asner, D.M.; Calancha, C.; Fujii, K.; Graf, N.; Haber, H.E.; Ishikawa, A.; Kanemura, S.; Kawada, S.; Kurata, M.; Miyamoto, A.; Neal, H.; Ono, H.; Potter, C.; Strube, J.; Suehara, T.; Tanabe, T.; Tian, J.; Tsumura, J.; Watanuki, S.; Weiglein, G.; Yagyu, K.; Yokoya, H.

    2013-01-01

    The ILC Higgs White Paper is a review of Higgs Boson theory and experiment at the International Linear Collider (ILC). Theory topics include the Standard Model Higgs, the two-Higgs doublet model, alternative approaches to electroweak symmetry breaking, and precision goals for Higgs boson experiments. Experimental topics include the measurement of the Higgs cross section times branching ratio for various Higgs decay modes at ILC center of mass energies of 250, 500, and 1000 GeV, and the extraction of Higgs couplings and the total Higgs width from these measurements. Luminosity scenarios based on the ILC TDR machine design are used throughout. The gamma-gamma collider option at the ILC is also discussed.

  3. ILC Higgs White Paper

    CERN Document Server

    Asner, D M; Calancha, C; Fujii, K; Graf, N; Haber, H E; Ishikawa, A; Kanemura, S; Kawada, S; Kurata, M; Miyamoto, A; Neal, H; Ono, H; Potter, C; Strube, J; Suehara, T; Tanabe, T; Tian, J; Tsumura, J; Watanuki, S; Weiglein, G; Yagyu, K; Yokoya, H

    2013-01-01

    The ILC Higgs White Paper is a review of Higgs Boson theory and experiment at the International Linear Collider (ILC). Theory topics include the Standard Model Higgs, the two-Higgs doublet model, alternative approaches to electroweak symmetry breaking, and precision goals for Higgs boson experiments. Experimental topics include the measurement of the Higgs cross section times branching ratio for various Higgs decay modes at ILC center of mass energies of 250, 500, and 1000 GeV, and the extraction of Higgs couplings and the total Higgs width from these measurements. Luminosity scenarios based on the ILC TDR machine design are used throughout. The gamma-gamma collider option at the ILC is also discussed.

  4. Physics highlights at ILC and CLIC

    CERN Document Server

    Lukić, Strahinja

    2015-01-01

    In this lecture, the physics potential for the e+e- linear collider experiments ILC and CLIC is reviewed. The experimental conditions are compared to those at hadron colliders and their intrinsic value for precision experiments, complementary to the hadron colliders, is discussed. The detector concepts for ILC and CLIC are outlined in their most important aspects related to the precision physics. Highlights from the physics program and from the benchmark studies are given. It is shown that linear colliders are a promising tool, complementing the LHC in essential ways to test the Standard Model and to search for new physics.

  5. Soil properties from seismic intrinsic dispersion

    NARCIS (Netherlands)

    Zhubayev, A. S.

    2014-01-01

    Theoretical and experimental studies in the past have shown the sensitivity of seismic waves to soil/rock properties, such as composition, porosity, pore fluid, and permeability. However, quantitative characterization of these properties has remained challenging. In case of unconsolidated soils, the

  6. Dynamics of intrinsic electrophysiological properties in spinal cord neurones

    DEFF Research Database (Denmark)

    Russo, R E; Hounsgaard, J

    1999-01-01

    . The intrinsic response properties of spinal neurones--determined by the particular set and distribution of voltage sensitive channels and their dynamic non-linear interactions--show a high degree of functional specialisation as reflected by the differences of intrinsic response patterns in different cell types....... Specialised, cell specific electrophysiological phenotypes gradually differentiate during development and are continuously adjusted in the adult animal by metabotropic synaptic interactions and activity-dependent plasticity to meet a broad range of functional demands....

  7. The effect of intrinsic soil properties on soil quality assessments

    Directory of Open Access Journals (Sweden)

    Alessandro Samuel-Rosa

    2013-10-01

    Full Text Available The assessment of soil quality is based on indicators and indices derived from soil properties. However, intrinsic soil properties may interfere with other soil properties that vary under different land uses and are used to calculate the indices. The aim of this study was to assess the extent to which intrinsic soil properties (clay and iron oxide contents explain variable soil properties (sum of bases, potential acidity, organic carbon, total porosity, and bulk density under different land uses (native forest, no-tillage and conventional agriculture on small family farms in Southern Brazil. The results showed that the five properties evaluated can be included in soil quality assessments and are not influenced by the clay and iron oxide contents. It was concluded that for little weathered 1:1 and 2:1 phyllosilicate rich-soils, if the difference between the maximum and the minimum clay content under the different land uses is less than about 200 g kg-1 and the iron oxide content less than about 15 g kg-1, the physico-chemical soil properties in the surface layer are determined mostly by the land use.

  8. Exploration of Beyond the Standard Model Physics at the ILC

    CERN Document Server

    Gori, Stefania

    2015-01-01

    The International Linear Collider (ILC) will advance our understanding of fundamental physics, through a program for precision measurements of the Higgs boson and of the top quark properties. An additional crucial goal of the ILC will be the direct discovery of light New Physics (NP) particles. This proceeding gives an overview of the ILC direct discovery potential. Special emphasis is dedicated to the discovery prospects for light hidden Supersymmetric particles, such as Higgsinos and staus. Furthermore, it will be extremely promising to have analyses aimed to the discovery of light hidden NP particles produced from new decay modes of the Higgs boson. The ILC low background environment, as well as the precise knowledge of the initial-state beams are also ideal for the precise measurements of the spectrum and interactions of these NP particles, once discovered.

  9. ILC Operating Scenarios

    CERN Document Server

    Barklow, T; Fujii, K; Gao, J; List, J; Walker, N; Yokoya, K

    2015-01-01

    The ILC Technical Design Report documents the design for the construction of a linear collider which can be operated at energies up to 500 GeV. This report summarizes the outcome of a study of possible running scenarios, including a realistic estimate of the real time accumulation of integrated luminosity based on ramp-up and upgrade processes. The evolution of the physics outcomes is emphasized, including running initially at 500 GeV, then at 350 GeV and 250 GeV. The running scenarios have been chosen to optimize the Higgs precision measurements and top physics while searching for evidence for signals beyond the standard model, including dark matter. In addition to the certain precision physics on the Higgs and top that is the main focus of this study, there are scientific motivations that indicate the possibility for discoveries of new particles in the upcoming operations of the LHC or the early operation of the ILC. Follow-up studies of such discoveries could alter the plan for the centre-of-mass collision...

  10. Friction Anisotropy: A unique and intrinsic property of decagonal quasicrystals

    Energy Technology Data Exchange (ETDEWEB)

    Mulleregan, Alice; Park, Jeong Young; Salmeron, Miquel; Ogetree, D.F.; Jenks, C.J.; Thiel, P.A.; Brenner, J.; Dubois, J.M.

    2008-06-25

    We show that friction anisotropy is an intrinsic property of the atomic structure of Al-Ni-Co decagonal quasicrystals and not only of clean and well-ordered surfaces that can be prepared in vacuum [J.Y. Park et al., Science (2005)]. Friction anisotropy is manifested both in nanometer size contacts obtained with sharp atomic force microscope (AFM) tips as well as in macroscopic contacts produced in pin-on-disc tribometers. We show that the friction anisotropy, which is not observed when an amorphous oxide film covers the surface, is recovered when the film is removed due to wear. Equally important is the loss of the friction anisotropy when the quasicrystalline order is destroyed due to cumulative wear. These results reveal the intimate connection between the mechanical properties of these materials and their peculiar atomic structure.

  11. TESLA & ILC Cryomodules

    Energy Technology Data Exchange (ETDEWEB)

    Peterson, T. J. [Fermi National Accelerator Laboratory (FNAL), Batavia, IL (United States); Weisend, II, J. G. [Fermi National Accelerator Laboratory (FNAL), Batavia, IL (United States)

    2016-01-01

    The TESLA collaboration developed a unique variant of SRF cryomodule designs, the chief feature being use of the large, low pressure helium vapor return pipe as the structural support backbone of the cryomodule. Additional innovative features include all cryogenic piping within the cryomodule (no parallel external cryogenic transfer line), long strings of RF cavities within a single cryomodule, and cryomodules connected in series. Several projects, including FLASH and XFEL at DESY, LCLS-II at SLAC, and the ILC technical design have adopted this general design concept. Advantages include saving space by eliminating the external transfer line, relatively tight packing of RF cavities along the beamline due to fewer warm-cold transitions, and potentially lower costs. However, a primary disadvantage is the relative lack of independence for warm-up, replacement, and cool-down of individual cryomodules.

  12. The ILC polarized electron source

    CERN Document Server

    Brachmann, Axel; Garwin, Edward; Kirby, Robert; Luh Dah An; Maruyama, Takashi; Prepost, Richard; Schultz, David; Sheppard, John

    2005-01-01

    The SLC polarized electron source (PES) can meet the expected requirements of the International Linear Collider (ILC) for polarization, charge and lifetime. However, experience with newer and successful PES designs at JLAB, Mainz and elsewhere can be incorporated into a first-generation ILC source that will emphasize reliability and stability without compromising the photocathode performance. The long pulse train for the ILC may introduce new challenges for the PES, and in addition more reliable and stable operation of the PES may be achievable if appropriate R&D is carried out for higher voltage operation and for a simpler load-lock system. The outline of the R&D program currently taking shape at SLAC and elsewhere is discussed. The principal components of the proposed ILC PES, including the laser system necessary for operational tests, are described.

  13. Intrinsic left-handed electromagnetic properties in anisotropic superconductors

    Science.gov (United States)

    Lin, Shi-Zeng; Chen, Hou-Tong

    2017-04-01

    Left-handed materials usually are realized in artificial subwavelength structures. Here, we show that some anisotropic superconductors such as Bi 2 Sr 2 CaCu 2 O 8 + δ , YBa 2 Cu x O y , and La 2 - x Sr x CuO 4 , are intrinsic left-handed materials. The condition is that the plasma frequency in the c axis, ωc, and in the ab plane, ωab, and the operating angular frequency, ω, satisfy ω c < ω < ω a b . In addition, ω should be smaller than the superconducting energy gap to sustain superconductivity. We study the reflection and transmission of electromagnetic waves and reveal negative refraction and the backward wave with the phase velocity opposite to the direction of energy flux propagation. We also discuss possible approaches for improvement, making these properties feasible for experimental validation. Being intrinsic left-hand materials, the anisotropic superconductors are promising for applications in functional electromagnetic devices in the terahertz frequency band.

  14. Intrinsic properties of larval zebrafish neurons in ethanol.

    Directory of Open Access Journals (Sweden)

    Hiromi Ikeda

    Full Text Available The behavioral effects of ethanol have been studied in multiple animal models including zebrafish. Locomotion of zebrafish larvae is resistant to high concentrations of ethanol in bath solution. This resistance has been attributed to a lower systemic concentration of ethanol in zebrafish when compared with bath solution, although the mechanism to maintain such a steep gradient is unclear. Here we examined whether the intrinsic properties of neurons play roles in this resistance. In order to minimize the contribution of metabolism and diffusional barriers, larvae were hemisected and the anterior half immersed in a range of ethanol concentrations thereby ensuring the free access of bath ethanol to the brain. The response to vibrational stimuli of three types of reticulospinal neurons: Mauthner neurons, vestibulospinal neurons, and MiD3 neurons were examined using an intracellular calcium indicator. The intracellular [Ca(2+] response in MiD3 neurons decreased in 100 mM ethanol, while Mauthner neurons and vestibulospinal neurons required >300 mM ethanol to elicit similar effects. The ethanol effect in Mauthner neurons was reversible following removal of ethanol. Interestingly, activities of MiD3 neurons displayed spontaneous recovery in 300 mM ethanol, suggestive of acute tolerance. Finally, we examined with mechanical vibration the startle response of free-swimming larvae in 300 mM ethanol. Ethanol treatment abolished long latency startle responses, suggesting a functional change in neural processing. These data support the hypothesis that individual neurons in larval zebrafish brains have distinct patterns of response to ethanol dictated by specific molecular targets.

  15. KEK GRID for ILC Experiments

    CERN Document Server

    Miyamoto, Akiya; Ikematsu, Katsumasa

    2010-01-01

    The LCG GRID system is the indispensable infrastructure for large scale computing required for ILC experiments. It had been used extensively for ILD LOI studies and its use will be further increased in coming DBD studies. Experiences during the LOI era and plan towards DBD study in KEK are presented.

  16. SM Precision Constraints at the LHC/ILC

    CERN Document Server

    Erler, J

    2007-01-01

    The prospects for electroweak precision physics at the LHC and the ILC are reviewed. This includes projections for measurements of the effective Z pole weak mixing angle, sin^2 theta_W (eff.), as well as top quark, W boson, and Higgs scalar properties. The upcoming years may also see very precise determinations of sin^2 theta_W (eff.) from lower energies.

  17. Exploratory Study of the X-Ray Properties of Quasars With Intrinsic Narrow Absorption Lines

    CERN Document Server

    Misawa, Toru; Chartas, George; Charlton, Jane C

    2008-01-01

    We have used archival Chandra and XMM-Newton observations of quasars hosting intrinsic narrow UV absorption lines (intrinsic NALs) to carry out an exploratory survey of their X-ray properties. Our sample consists of three intrinsic-NAL quasars and one "mini-BAL" quasar, plus four quasars without intrinsic absorption lines for comparison. These were drawn in a systematic manner from an optical/UV-selected sample. The X-ray properties of intrinsic-NAL quasars are indistinguishable from those of "normal" quasars. We do not find any excess absorption in quasars with intrinsic NALs, with upper limits of a few times 10^22 cm^-2. We compare the X-ray and UV properties of our sample quasars by plotting the equivalent width and blueshift velocity of the intrinsic NALs and the X-ray spectral index against the "optical-to-X-ray" slope, alpha-ox. When BAL quasars and other AGNs with intrinsic NALs are included, the plots suggest that intrinsic-NAL quasars form an extension of the BAL sequences and tend to bridge the gap ...

  18. Study on ILC bunch compressor

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    In this paper, we have found a new set of parameters for the short two-stage ILC bunch compres-sors. The RF sections are both in the accelerating phase rather than the decelerating phase to improve the accelerating efficiency. We have also studied the CSR related issues. The results show that the microbunch instability exists extensively in the second bunch compressor, but the emittance dilution is small due to the relatively long bunch.

  19. Intrinsic and extrinsic mechanical properties related to the differentiation of mesenchymal stem cells.

    Science.gov (United States)

    Lee, Jin-Ho; Park, Hun-Kuk; Kim, Kyung Sook

    2016-05-06

    Diverse intrinsic and extrinsic mechanical factors have a strong influence on the regulation of stem cell fate. In this work, we examined recent literature on the effects of mechanical environments on stem cells, especially on differentiation of mesenchymal stem cells (MSCs). We provide a brief review of intrinsic mechanical properties of single MSC and examined the correlation between the intrinsic mechanical property of MSC and the differentiation ability. The effects of extrinsic mechanical factors relevant to the differentiation of MSCs were considered separately. The effect of nanostructure and elasticity of the matrix on the differentiation of MSCs were summarized. Finally, we consider how the extrinsic mechanical properties transfer to MSCs and then how the effects on the intrinsic mechanical properties affect stem cell differentiation.

  20. ILC2s and fungal allergy

    Directory of Open Access Journals (Sweden)

    Hirohito Kita

    2015-07-01

    Full Text Available Innate lymphoid cells (ILCs have emerged recently as an important component of the immune system and the cell type that regulates mucosal immune responses and tissue homeostasis. Group 2 ILCs (ILC2s, a subset of ILCs, reside in various tissues and are characterized by their capacity to produce type 2 cytokines and tissue growth factors. These ILC2s play an important role in allergic immune responses by linking signals in the atmospheric environment to the immune system. Fungi are one of the major allergens associated with human asthma, and animal and in vitro models using the fungal allergens have provided significant information toward our understanding of the mechanisms of allergic disease. In mouse models of fungus-induced allergic airway inflammation, IL-33, IL-25, and TSLP are released by airway epithelial cells. Lung ILC2s that respond to these cytokines quickly produce a large quantity of type 2 cytokines, resulting in airway eosinophilia, mucus production, and airway hyperreactivity even in the absence of adaptive immune cells. Evidence also suggests that ILC2s interact with conventional immune cells, such as CD4+ T cells, and facilitate development of adaptive immune response and persistent airway inflammation. ILC2s are also present in respiratory mucosa in humans. Further investigations into the biology of ILC2s and their roles in the pathophysiology of allergic diseases will provide major conceptual advances in the field and may provide useful information toward development of new therapeutic strategies for patients.

  1. ILC Reference Design Report Volume 4 - Detectors

    CERN Document Server

    Behnke, Ties; Jaros, John; Miyamoto, Akiya; Dabrowski, Wladyslaw; Gajewski, Jan; Idzik, Marek; Kisielewska, Danuta; Kulis, Szymon; Suszycki, Leszek; Swientek, Krzysztof; Martyn, Hans-Ulrich; Bernreuther, Werner; Feld, Lutz; Hebbeker, Thomas; Muennich, Astrid; Roth, Stefan; Stahl, Achim; Tonutti, Manfred; Rindani, Saurabh; Sarkar, Utpal; Singh, S.K.; Adloff, Catherine; Delebecque, Pierre; Hermel, Richard; Karyotakis, Yannis; Lafaye, Remi; Prast, Julie; Muhlleitner, Milada Margarete; Singh, R.K.; Wagner, Carlos E.M.; Antipov, Sergei; Arnold, Ned; Berger, Edmond; Carwardine, John; Drake, Gary; Emery, Louis; Friedsam, Horst; Fuerst, Joel; Gai, Wei; Gerbick, Scot; Gerig, Rod; Kelly, Michael; Kim, Kwang-Je; Lenkszus, Frank; Liu, Wanming; Magill, Stephen; Noonan, John; Repond, Jose; Saunders, Claude; Shepard, Ken; Underwood, David G.; Wang, Haitao; Weerts, Harry; Xia, Lei; Xiao, Aimin; Zhang, Jinlong; Yock, Philip; Singh, Bhartendu K.; Ananthanarayan, B.; Biswal, S.S.; Godbole, Rohini; Vempati, Sundir K.; Comerma, Albert; Dieguez, Angel; Garrido, Luis; Gascon, David; Graciani, Ricardo; Grauges, Eugeni; Herms, Atila; Balbuena, Juan Pablo; Cabruja, Enric; Lozano, Manuel; Pellegrini, Giulio; Miquel, Ramon; Lux, Thorsten; Martinez, Manel; Padilla, Cristobal; Riu, Imma; Ward, Bennie; Sun, Yipeng; Ablikim, Medina; Bai, Sha; Bi, Xiao-Jun; Cao, J.S.; Chen, He Sheng; Chen, Sen Yu; Chen, Yuan Bo; Cheng, Jian; Chi, Yun Long; Dai, Jian Ping; Dong, Dong; Dong, Hai Yi; Du, Shuxian; Fang, Shou Xian; Gao, Jian She; Gao, Jie; Ge, Ming Qi; Ge, Rui; Geng, Zhe Qiao; Gu, Jun; He, An; Hou, Mi; Hu, Tao; Huang, Tong Ming; Jiang, Xiao Ming; Jin, Shan; Kang, Wen; Kong, Xiang Cheng; Li, Chun Hua; Li, Da Zhang; Li, Gang; Li, Shao Peng; Li, Weiguo; Li, Xiao Ping; Li, Zhong Quan; Liu, Shao Zhen; Liu, Wei Bin; Liu, Ya Ping; Liu, Yu Dong; Lu, Cai-Dian; Ma, Li; Ma, Qiang; Ouyang, Qun; Pam, Wei Min; Pei, Guo Xi; Pei, Shi Lun; Peng, G.X.; Qin, Qing; Qu, Hua Min; Shi, Cai Tu; Sun, Hong; Sun, Yi; Wang, Chun Hong; Wang, Dou; Wang, Guang Wei; Wang, Jiang; Wang, Jiu Qing; Wang, Shu Hong; Wang, Yi Fang; Wang, Zheng; Xie, Jia Lin; Xing, Zhi-Zhong; Xu, Gang; Xu, Qing Jin; Yu, Cheng Hui; Yu, Xian Ming; Yuan, Chang-Zheng; Yue, Jun Hui; Zhai, Ji Yuan; Zhang, Chuang; Zhang, He; Zhang, Jiawen; Zhang, Jing Ru; Zhang, Jing; Zhang, X.; Zhang, Yuan; Zhao, Ji Jiu; Zhao, Jing Xia; Zhao, Sheng Chu; Zhou, De Min; Zhou, Shun; Zhu, Xiong Wei; Zong, Zhang Guo; Liu, Chun; Wu, Yue Liang; Yang, Jin Min; Liang, Jian Tao; Liu, Li Qiang; Lu, Wen Hui; Xiong, Lian You; Zhang, Liang; Zhao, Tong Xian; Afanaciev, Konstantin; Ignatenko, Alexandr; Shumeiko, Nikolai; Manghisoni, Massimo; Re, Valerio; Traversi, Gianluca; Eigen, Gerald; Osland, Per; Handu, Virender K.; Jawale, Suresh B.; Joshi, Gopal; Pande, Manjiri; Pande, Rajni; Rao, Sista V.L.S.; Singh, Pitamber; Sinha, Anil K.; Suthar, Rameshwar L.; Topkar, Anita; Adey, David; Hawkes, Chris; Hillier, Stephen James; Mikami, Yoshinari; Miller, Owen; Stockton, Mark; Watson, Nigel Keith; Wilson, John A.; Petersen, Troels Christian; Driouichi, Chafik; Hansen, Jorgen Beck; Hansen, Jorn Dines; Klinkby, Esben; Xella, Stefania; Von Toerne, Eckhard; Brock, Ian; Desch, Klaus; Dreiner, Herbert; Hohlfeld, Mark; Killenberg, Martin; Kittel, Olaf; Koch, Manuel; Kohrs, Robert; Krautscheid, Thorsten; Kruger, Hans; Langenfeld, Ulrich; Pleier, Marc-Andre; Reuen, Lars; Ummenhofer, Martin; Wermes, Norbert; Wienemann, Peter; Butler, John; Cussans, David; Goldstein, Joel; Grimes, Mark; Heath, Helen; Lynch, Clare; Velthuis, Jaap J.; Hearty, Christopher; Mattison, Thomas; Anerella, Michael; Dawson, Sally; Marone, Andrew; Morse, William Michael; Parker, Brett; Parsa, Zohreh; Pogorelsky, Igor; Radeka, Veljko; Yakimenko, Vitaly; Partridge, Richard; Narain, Meenakshi; Coca, Cornelia; Orlandea, Marius Ciprian; Popescu, Sorina; Teodorescu, Eliza; Hajdu, Csaba; Horvath, Dezso; Christophe, Grojean; Baddams, Nigel; Baldy, Jean-Luc; Camporesi, Tiziano; Capatina, Ofelia; De Roeck, Albert; Delahaye, Jean-Pierre; Eliasson, Peder; Ellis, John R.; Ferguson, John; Gastal, Martin; Hauschild, Michael; Hauviller, Claude; Hawkings, Richard; Kraml, Sabine; Latina, Andrea; Parma, Vittorio; Pedersen, John; Quesnel, Jean-Pierre; Rinolfi, Louis; Rolandi, Gigi; Ruehl, Ingo; Sauli, Fabio; Schulte, Daniel; Tavian, Laurent; Zimmermann, Frank; Chung, Jin-Hyuk; Hwang, Youngseok; Kim, Donghee; Kim, Eun San; Kim, Guinyun; Kim, Hongjoo; Kim, Hyoungsuk; Kim, Kyung Sook; Kim, Youngim; Park, Hwanbae; Shin, Seunghwan; Son, Dongchul; Suh, Jun Suhk; Bhattacherjee, Biplob; Datta, Anindya; Ghosh, Kirtiman; Kundu, Anirban; Bhandari, R.K.; Chattopadhyay, Subhasis; Mallik, C.; Nabhiraj, P.Y.

    2007-01-01

    This report, Volume IV of the International Linear Collider Reference Design Report, describes the detectors which will record and measure the charged and neutral particles produced in the ILC's high energy e+e- collisions. The physics of the ILC, and the environment of the machine-detector interface, pose new challenges for detector design. Several conceptual designs for the detector promise the needed performance, and ongoing detector R&D is addressing the outstanding technological issues. Two such detectors, operating in push-pull mode, perfectly instrument the ILC interaction region, and access the full potential of ILC physics.

  2. 750 GeV diphoton resonance at the ILC

    CERN Document Server

    Fujii, Keisuke; Yokoya, Hiroshi

    2016-01-01

    In this paper we study the direct production of the diphoton resonance $X$ which has been suggested by 2015 data at the LHC, in $e^+e^-\\to X\\gamma/XZ$ processes at the ILC. We derive an analytic expression for the scattering amplitudes of these processes, and present a comprehensive analysis for determining the properties of $X$ at the ILC. A realistic simulation study for $e^+e^-\\to X\\gamma$ is performed based on the full detector simulation to demonstrate the capabilities of the ILC experiment. Complementary to the searches at the LHC, prospects of the measurement of the absolute values of production cross-section are obtained for the ILC using recoil technique without assuming decay modes of $X$. In addition, we have studied the searches for $X\\to\\rm{invisible}$ and $X\\to b\\bar{b}$ modes, which are challenging at the LHC, and found that these decay modes can be discovered with high significance if their branching ratios are large enough.

  3. Arginase 1 is an innate lymphoid cell-intrinsic metabolic checkpoint controlling type 2 inflammation

    Science.gov (United States)

    Monticelli, Laurel A; Buck, Michael D; Flamar, Anne-Laure; Saenz, Steven A; Wojno, Elia D Tait; Yudanin, Naomi A; Osborne, Lisa C; Hepworth, Matthew R; Tran, Sara V; Rodewald, Hans-Reimer; Shah, Hardik; Cross, Justin R; Diamond, Joshua M; Cantu, Edward; Christie, Jason D; Pearce, Erika L; Artis, David

    2016-01-01

    Group 2 innate lymphoid cells (ILC2s) regulate tissue inflammation and repair following activation by cell-extrinsic factors including host-derived cytokines. However, the cell-intrinsic metabolic pathways that control ILC2 function are undefined. Here we demonstrate that expression of the enzyme Arginase 1 (Arg1) is a conserved trait of murine and human ILC2s during acute or chronic lung inflammation. Deletion of murine ILC-intrinsic Arg1 abrogated type 2 lung inflammation by restraining ILC2 proliferation and dampening cytokine production. Mechanistically, inhibition of Arg1 enzymatic activity disrupted multiple components of ILC2 metabolic programming by altering arginine catabolism, impairing polyamine biosynthesis and reducing aerobic glycolysis. These data identify Arg1 as a key regulator of ILC2 bioenergetics, controlling proliferative capacity and pro-inflammatory functions that promote type 2 inflammation. PMID:27043409

  4. Combined intrinsic elastocaloric and electrocaloric properties of ferroelectrics

    Science.gov (United States)

    Khassaf, H.; Patel, T.; Alpay, S. P.

    2017-04-01

    In multiferroic materials, adiabatic temperature changes can be obtained by the combined application of electric, stress, and magnetic fields. These external stimuli provide additional channels of entropy variations resulting in a multi-caloric response. In ferroelectric (FE) materials, caloric responses can be obtained with the application of electric and mechanical fields. Here, we compute the intrinsic elastocaloric and stress-mediated electrocaloric behavior of prototypical FE materials using the Landau-Devonshire theory of phase transformations with appropriate electrical and electro-mechanical boundary conditions. We show that an elastocaloric adiabatic temperature variation of 12.7 °C can be obtained in PbTiO3 with the application of uniaxial tensile stress of 500 MPa near its Curie point. This is 59% higher than its pure intrinsic electrocaloric response for an electric field difference of 100 kV/cm. Moreover, external stresses allow the maximum electro-elastocaloric response to be tuned towards room temperature. Our calculations show that relaxor FEs should exhibit large adiabatic temperature variations in relatively broad temperature ranges. These findings indicate that caloric responses in ferroic materials can be deterministically controlled and enhanced by utilizing a variety of external stimuli.

  5. Is spatial autocorrelation an intrinsic property of territory size?

    Science.gov (United States)

    Valcu, Mihai; Kempenaers, Bart

    2010-03-01

    In animals, competition for space and resources often results in territorial behaviour. The size of a territory is an important correlate of fitness and is primarily determined by the spatial distribution of resources and by interactions between competing individuals. Both of these determinants, alone or in interaction, could lead to spatial non-independence of territory size (i.e. spatial autocorrelation). We investigated the presence and magnitude of spatial autocorrelation (SAC) in territory size using Monte Carlo simulations of the most widely used territory measures. We found significant positive SAC in a wide array of competition-simulated conditions. A meta-analysis of territory size data showed that SAC is also a feature of territories mapped based on behavioural observations. Our results strongly suggest that SAC is an intrinsic trait of any territory measure. Hence, we recommend that appropriate statistical methods should be employed for the analysis of data sets where territory size is either a dependent or an explanatory variable.

  6. Intrinsic phonon properties of double-walled carbon nanotubes

    Science.gov (United States)

    Tran, H. N.; Levshov, D. I.; Nguyen, V. C.; Paillet, M.; Arenal, R.; Than, X. T.; Zahab, A. A.; Yuzyuk, Y. I.; Phan, N. M.; Sauvajol, J.-L.; Michel, T.

    2017-03-01

    Double-walled carbon nanotubes (DWNT) are made of two concentric and weakly van der Waals coupled single-walled carbon nanotubes (SWNT). DWNTs are the simplest systems for studying the mechanical and electronic interactions between concentric carbon layers. In this paper we review recent results concerning the intrinsic features of phonons of DWNTs obtained from Raman experiments performed on index-identified DWNTs. The effect of the interlayer distance on the strength of the mechanical and electronic coupling between the layers, and thus on the frequencies of the Raman-active modes, namely the radial breathing-like modes (RBLMs) and G-modes, are evidenced and discussed. Invited talk at 8th International Workshop on Advanced Materials Science and Nanotechnology (IWAMSN2016), 8–12 November 2016, Ha Long City, Vietnam.

  7. Reconsidering the role of neuronal intrinsic properties and neuromodulation in vestibular homeostasis

    Directory of Open Access Journals (Sweden)

    Mathieu eBeraneck

    2012-02-01

    Full Text Available The sensorimotor transformations performed by central vestibular neurons (2°VN constantly adapt as the animal faces conflicting sensory information or sustains injuries. In order to ensure the homeostasis of vestibular-related functions, neural changes could in part rely on the regulation of 2°VN intrinsic properties. Here, we review evidence which demonstrates modulation and plasticity of 2°VN intrinsic properties. We first present partition of rodents 2°VN into distinct subtypes, namely type A and type B. Then, we focus on the respective properties of each type and their putative roles in vestibular functions. The intrinsic properties of 2°VN can be swiftly modulated by a wealth of neuromodulators, to adapt rapidly, for example, to temporary changes of the ecophysiological surroundings. To illustrate how intrinsic excitability can rapidly be modified in physiological conditions and therefore be targeted in the clinic, we present the modulation of vestibular reflexes in relation to the neuromodulatory fluctuation of the sleep/wake cycle. On the other hand, intrinsic properties can also be slowly yet deeply modified in response to major perturbations as is the case following a unilateral labyrinthectomy (UL. We revisit the experimental evidence which demonstrate that drastic alterations of the 2°VN intrinsic properties occur following UL, however with a slow dynamic, more on par with the compensation of dynamic deficits than static ones. Data are interpreted in the framework of a distributed process which progress from the global, large scale coping mechanisms (e.g. changes in behavioural strategies to the local, small scale ones (e.g. changes in intrinsic properties. Within this framework, the compensation of dynamic deficits improves with time as deeper modifications are engraved within the finer parts of the vestibular-related networks. Finally, we propose perspectives and working hypotheses to pave the way for future research aiming at

  8. Intrinsic physical properties and Doppler boosting effects in LSI+61303

    CERN Document Server

    Massi, M

    2014-01-01

    Our aim is to show how variable Doppler boosting of an intrinsically variable jet can explain the long-term modulation of 1667 \\pm 8 days observed in the radio emission of LSI+61303. The physical scenario is that of a conical, magnetized plasma jet having a periodical (P1) increase of relativistic particles, Nrel, at a specific orbital phase, as predicted by accretion in the eccentric orbit of LSI+61303. Jet precession (P2) changes the angle, eta, between jet axis and line of sight, thereby inducing variable Doppler boosting. The problem is defined in spherical geometry, and the optical depth through the precessing jet is calculated by taking into account that the plasma is stratified along the jet axis. The synchrotron emission of such a jet was calculated and we fitted the resulting flux density Smodel(t) to the observed flux density obtained during a 6.5-year monitoring of LSI+61303 by the Green Bank radio interferometer. Our physical model for the system LSI+61303 is not only able to reproduce the long-te...

  9. Illuminating Dark Matter at the ILC

    CERN Document Server

    Dreiner, Herbert; Krämer, Michael; Schmeier, Daniel; Tattersall, Jamie

    2012-01-01

    The WIMP (weakly interacting massive particle) paradigm for dark matter is currently being probed via many different experiments. Direct detection, indirect detection and collider searches are all hoping to catch a glimpse of these elusive particles. Here, we examine the potential of the ILC (International Linear Collider) to shed light on the origin of dark matter. By using an effective field theory approach we are also able to compare the reach of the ILC with that of the other searches. We find that for low mass dark matter (< 10 GeV), the ILC offers a unique opportunity to search for WIMPS beyond any other experiment. In addition, if dark matter happens to only couple to leptons or via a spin dependent interaction, the ILC can give an unrivalled window to these models. We improve on previous ILC studies by constructing a comprehensive list of effective theories that allows us to move beyond the non-relativistic approximation.

  10. Development and modulation of intrinsic membrane properties control the temporal precision of auditory brain stem neurons.

    Science.gov (United States)

    Franzen, Delwen L; Gleiss, Sarah A; Berger, Christina; Kümpfbeck, Franziska S; Ammer, Julian J; Felmy, Felix

    2015-01-15

    Passive and active membrane properties determine the voltage responses of neurons. Within the auditory brain stem, refinements in these intrinsic properties during late postnatal development usually generate short integration times and precise action-potential generation. This developmentally acquired temporal precision is crucial for auditory signal processing. How the interactions of these intrinsic properties develop in concert to enable auditory neurons to transfer information with high temporal precision has not yet been elucidated in detail. Here, we show how the developmental interaction of intrinsic membrane parameters generates high firing precision. We performed in vitro recordings from neurons of postnatal days 9-28 in the ventral nucleus of the lateral lemniscus of Mongolian gerbils, an auditory brain stem structure that converts excitatory to inhibitory information with high temporal precision. During this developmental period, the input resistance and capacitance decrease, and action potentials acquire faster kinetics and enhanced precision. Depending on the stimulation time course, the input resistance and capacitance contribute differentially to action-potential thresholds. The decrease in input resistance, however, is sufficient to explain the enhanced action-potential precision. Alterations in passive membrane properties also interact with a developmental change in potassium currents to generate the emergence of the mature firing pattern, characteristic of coincidence-detector neurons. Cholinergic receptor-mediated depolarizations further modulate this intrinsic excitability profile by eliciting changes in the threshold and firing pattern, irrespective of the developmental stage. Thus our findings reveal how intrinsic membrane properties interact developmentally to promote temporally precise information processing.

  11. Intrinsic and integrative properties of substantia nigra pars reticulata neurons

    Science.gov (United States)

    Zhou, Fu-Ming; Lee, Christian R.

    2011-01-01

    The GABA projection neurons of the substantia nigra pars reticulata (SNr) are output neurons for the basal ganglia and thus critical for movement control. Their most striking neurophysiological feature is sustained, spontaneous high frequency spike firing. A fundamental question is: what are the key ion channels supporting the remarkable firing capability in these neurons? Recent studies indicate that these neurons express tonically active TRPC3 channels that conduct a Na-dependent inward current even at hyperpolarized membrane potentials. When the membrane potential reaches −60 mV, a voltage-gated persistent sodium current (INaP) starts to activate, further depolarizing the membrane potential. At or slightly below −50 mV, the large transient voltage-activated sodium current (INaT) starts to activate and eventually triggers the rapid rising phase of action potentials. SNr GABA neurons have a higher density of (INaT), contributing to the faster rise and larger amplitude of action potentials, compared with the slow-spiking dopamine neurons. INaT also recovers from inactivation more quickly in SNr GABA neurons than in nigral dopamine neurons. In SNr GABA neurons, the rising phase of the action potential triggers the activation of high-threshold, inactivation-resistant Kv3-like channels that can rapidly repolarize the membrane. These intrinsic ion channels provide SNr GABA neurons with the ability to fire spontaneous and sustained high frequency spikes. Additionally, robust GABA inputs from direct pathway medium spiny neurons in the striatum and GABA neurons in the globus pallidus may inhibit and silence SNr GABA neurons, whereas glutamate synaptic input from the subthalamic nucleus may induce burst firing in SNr GABA neurons. Thus, afferent GABA and glutamate synaptic inputs sculpt the tonic high frequency firing of SNr GABA neurons and the consequent inhibition of their targets into an integrated motor control signal that is further fine-tuned by neuromodulators

  12. ILC in 2012: Decisions ahead!

    CERN Multimedia

    Barry Barish, Director of the Global Design Effort for the International Linear Collider

    2012-01-01

    The 2000 or so people from around the world who are planning and developing the International Linear Collider (ILC) are starting to get this funny feeling when something that you have been working on and looking forward to for a long, long time is suddenly just around the corner.   Simulation of a Higgs event in a future ILC detector. Copyright: DESY 2006. 2012 will be a big one for the potential next big thing in particle physics: towards the end of the year the community plans to release its Technical Design Report, that all-important publication that basically says “we’re ready – just say the word”. Of course the future of particle physics in the world depends crucially on results from the LHC, so we are all curious (on the edge of our seats may describe it more appropriately) to see what the big discovery machine will tell us about Standard Model Higgs particles (or not), dark matter and all those other unsolved mysteries on which...

  13. ILC in 2012: Decisions ahead!

    CERN Multimedia

    Barry Barish, Director of the Global Design Effort for the International Linear Collider

    2011-01-01

    The 2000 or so people from around the world who are planning and developing the International Linear Collider (ILC) are starting to get this funny feeling when something that you have been working on and looking forward to for a long, long time is suddenly just around the corner.   Simulation of a Higgs event in a future ILC detector. Copyright: DESY 2006. 2012 will be a big one for the potential next big thing in particle physics: towards the end of the year the community plans to release its Technical Design Report, that all-important publication that basically says “we’re ready – just say the word”. Of course the future of particle physics in the world depends crucially on results from the LHC, so we are all curious (on the edge of our seats may describe it more appropriately) to see what the big discovery machine will tell us about Standard Model Higgs particles (or not), dark matter and all those other unsolved mysteries on which...

  14. Intrinsic control of electroresponsive properties of transplanted mammalian brain neurons

    DEFF Research Database (Denmark)

    Hounsgaard, J; Yarom, Y

    1985-01-01

    The present study presents the first analysis of neurons in mammalian brain transplants based on intracellular recording. The results, obtained in brain slices including both donor and host tissue, showed that neuronal precursor cells in embryonic transplants retained their ability to complete...... their normal differentiation of cell-type-specific electroresponsive properties. Distortions in cell aggregation and synaptic connectivity did not affect this aspect of neuronal differentiation....

  15. Characteristic of innate lymphoid cells (ILC

    Directory of Open Access Journals (Sweden)

    Mateusz Adamiak

    2014-12-01

    Full Text Available Innate lymphoid cells (ILC is a newly described family of immune cells that are part of the natural immunity which is important not only during infections caused by microorganisms, but also in the formation of lymphoid tissue, tissue remodeling after damage due to injury and homeostasis tissue stromal cells. Family ILC cells form NK cells (natural killer and lymphoid tissue inducer T cells (LTi, which, although they have different functions, are evolutionarily related. NK cells are producing mainly IFN-γ, whereas LTi cells as NKR+LTi like, IL-17 and/or IL-22, which suggests that the last two cells, can also represent the innate versions of helper T cell - TH17 and TH22. Third population of ILC is formed by cells with characteristics such as NK cells and LTi (ILC22 - which are named NK22 cells, natural cytotoxicity receptor 22 (NCR22 cells or NK receptor-positive (LTi NKR+ LTi cells. Fourth population of ILC cells are ILC17 - producing IL-17, while the fifth is formed by natural helper type 2 T cells (nTH2, nuocyte, innate type 2 helper cells (IH2 and multi-potent progenitor type 2 cells (MPPtype2. Cells of the last population synthesize IL-5 and IL-13. It is assumed that an extraordinary functional diversity of ILC family, resembles T cells, probably because they are under the control of the corresponding transcription factors - as direct regulation factors, such as the family of lymphocytes T.

  16. Galvanic apparent internal impedance: an intrinsic tissue property.

    Science.gov (United States)

    Golberg, Alex; Rabinowitch, Haim D; Rubinsky, Boris

    2009-11-01

    Using basic galvanic cell principles, the ability of tissues to generate electrical current through electrolysis was characterized. Studying Zn/Cu electrolysis in animal organs revealed a fundamental and measurable tissue-specific property - the galvanic apparent internal impedance (GAII), that is most likely related to the salt bridge function of tissues delineated by electrodes. Further to the fundamental knowledge acquired, GAII enables a new diagnostic method to distinguish between tissue types and to determine their health status without a need for expensive calibration, as often required when external power source is used. We demonstrated the GAII sensitivity in detecting tissue ablation with microwave heating or irreversible electroporation. The results open the way for a novel, inexpensive self-powered tissue diagnostic system for a wide range of applications such as minimally invasive tissue health status, ischemia, hydration, real time intra-operative control of minimally invasive surgery, medical imaging, virtual biopsy and many others.

  17. Prototyping of the ILC Baseline Positron Target

    Energy Technology Data Exchange (ETDEWEB)

    Gronberg, J; Brooksby, C; Piggott, T; Abbott, R; Javedani, J; Cook, E

    2012-02-29

    The ILC positron system uses novel helical undulators to create a powerful photon beam from the main electron beam. This beam is passed through a titanium target to convert it into electron-positron pairs. The target is constructed as a 1 m diameter wheel spinning at 2000 RPM to smear the 1 ms ILC pulse train over 10 cm. A pulsed flux concentrating magnet is used to increase the positron capture efficiency. It is cooled to liquid nitrogen temperatures to maximize the flatness of the magnetic field over the 1 ms ILC pulse train. We report on prototyping effort on this system.

  18. Design of the ILC Crab Cavity System

    Energy Technology Data Exchange (ETDEWEB)

    Adolphsen, C.; Beard, C.; Bellantoni, L.; Burt, G.; Carter, R.; Chase, B.; Church, M.; Dexter, A.; Dykes, M.; Edwards, H.; Goudket, P; Jenkins, R.; Jones, R.M.; Kalinin,; Khabiboulline, T.; Ko, K.; Latina, A.; Li, Z.; Ma, L.; McIntosh, P.; Ng, C.; /SLAC /Daresbury /Fermilab /Cockcroft Inst. Accel. Sci. Tech. /CERN

    2007-08-15

    The International Linear Collider (ILC) has a 14 mrad crossing angle in order to aid extraction of spent bunches. As a result of the bunch shape at the interaction point, this crossing angle at the collision causes a large luminosity loss which can be recovered by rotating the bunches prior to collision using a crab cavity. The ILC baseline crab cavity is a 9-cell superconducting dipole cavity operating at a frequency of 3.9 GHz. In this paper the design of the ILC crab cavity and its phase control system, as selected for the RDR in February 2007 is described in fuller detail.

  19. 500 GeV ILC Operating Scenarios

    CERN Document Server

    Brau, James E; Barklow, T; Brau, J; Fujii, K; Gao, J; List, J; Walker, N; Yokoya, K

    2015-01-01

    The ILC Technical Design Report documents the design of a 500 GeV linear collider, but does not specify the center-of-mass energy steps of operation for the collider. The ILC Parameters Joint Working Group has studied possible running scenarios, including a realistic estimate of the real time accumulation of integrated luminosity based on ramp-up and upgrade processes, and considered the evolution of the physics outcomes. These physics goals include Higgs precision measurements, top quark measurements and searches for new physics. We present an "optimized" operating scenario and the anticipated evolution of the precision of the ILC measurements.

  20. Availability and Reliability Issues for ILC

    Energy Technology Data Exchange (ETDEWEB)

    Himel, T.; Nelson, J.; Phinney, N.; /SLAC; Ross, M.; /Fermilab

    2007-06-27

    The International Linear Collider (ILC) will be the largest most complicated accelerator ever built. For this reason extensive work is being done early in the design phase to ensure that it will be reliable enough. This includes gathering failure mode data from existing accelerators and simulating the failures and repair times of the ILC. This simulation has been written in a general fashion using MATLAB and could be used for other accelerators. Results from the simulation tool have been used in making some of the major ILC design decisions and an unavailability budget has been developed.

  1. WIMP search and a Cherenkov detector prototype for ILC polarimetry

    Energy Technology Data Exchange (ETDEWEB)

    Bartels, Christoph

    2011-10-15

    The planned International Linear Collider (ILC) will be an essential experiment to precisely determine the properties and structure of physics at the TeV scale. An important feature of the ILC is the possibility to use polarized electrons and positrons. In part 1 of this thesis, a model independent search for Weakly Interacting Massive Particles (WIMPs) at ILC is presented. The signal channel under study is direct WIMP pair production with associated Initial State Radiation (ISR), e{sup +}e{sup -} {yields} {chi}{chi}{gamma}, where the WIMPs leave the detector without any further interaction, and only the emitted photon is detected. From the energy spectrum of the detected photons the coupling structure, cross sections, masses and the quantum number of the dominant partial wave in the production process can be inferred. The analysis includes the dominant SM, as well as machine-induced backgrounds, and is performed using a full simulation of the ILD detector concept. For an integrated luminosity of L=500 fb{sup -1}, the signal cross sections can be measured to a precision of 3%, dominated by systematic uncertainties on the polarization measurement of the initial electrons and positrons. Masses can be measured to a precision of up to 2% by a comparison of the data photon spectrum to parametrized template spectra. In part 2 of this thesis, a Cherenkov detector prototype for Compton polarimetry at ILC is presented. For the polarization measurement a systematic uncertainty of {delta} P/P = 0.25% or better is envisioned. To achieve this goal, the Cherenkov detector has to be precisely aligned with the fan of Compton scattered electrons and its signal response needs to be highly linear. For the detector prototype data driven alignment strategies have been developed by comparing data recorded at the Elsa accelerator in Bonn, Germany, with detailed Geant4 simulations. With the use of multi-anode photomultipliers, data driven alignment strategies promise to provide the

  2. Forward Instrumentation for ILC Detectors

    CERN Document Server

    Abramowicz, Halina; Afanaciev, Konstantin; Aguilar, Jonathan; Ambalathankandy, Prasoon; Bambade, Philip; Bergholz, Matthias; Bozovic-Jelisavcic, Ivanka; Castro, Elena; Chelkov, Georgy; Coca, Cornelia; Daniluk, Witold; Dragone, Angelo; Dumitru, Laurentiu; Elsener, Konrad; Emeliantchik, Igor; Fiutowski, Tomasz; Gostkin, Mikhail; Grah, Christian; Grzelak, Grzegorz; Haller, Gunter; Henschel, Hans; Ignatenko, Alexandr; Idzik, Marek; Ito, Kazutoshi; Jovin, Tatjana; Kielar, Eryk; Kotula, Jerzy; Krumstein, Zinovi; Kulis, Szymon; Lange, Wolfgang; Lohmann, Wolfgang; Levy, Aharon; Moszczynski, Arkadiusz; Nauenberg, Uriel; Novgorodova, Olga; Ohlerich, Marin; Orlandea, Marius; Oleinik, Gleb; Oliwa, Krzysztof; Olshevski, Alexander; Pandurovic, Mila; Pawlik, Bogdan; Przyborowski, Dominik; Sato, Yutaro; Sadeh, Iftach; Sailer, Andre; Schmidt, Ringo; Schumm, Bruce; Schuwalow, Sergey; Smiljanic, Ivan; Swientek, Krzysztof; Takubo, Yosuke; Teodorescu, Eliza; Wierba, Wojciech; Yamamoto, Hitoshi; Zawiejski, Leszek; Zhang, Jinlong

    2010-01-01

    Two special calorimeters are foreseen for the instrumentation of the very forward region of the ILC detector, a luminometer designed to measure the rate of low angle Bhabha scattering events with a precision better than 10-3 and a low polar angle calorimeter, adjacent to the beam-pipe. The latter will be hit by a large amount of beamstrahlung remnants. The amount and shape of these depositions will allow a fast luminosity estimate and the determination of beam parameters. The sensors of this calorimeter must be radiation hard. Both devices will improve the hermeticity of the detector in the search for new particles. Finely segmented and very compact calorimeters will match the requirements. Due to the high occupancy fast front-end electronics is needed. The design of the calorimeters developed and optimised with Monte Carlo simulations is presented. Sensors and readout electronics ASICs have been designed and prototypes are available. Results on the performance of these major components are summarised.

  3. 20-MW Magnicon for ILC

    Energy Technology Data Exchange (ETDEWEB)

    Jay L. Hirshfield

    2006-11-29

    The 1.3 GHz RF power to drive ILC is now planned to be supplied by 600-1200, 10-MW peak power multi-beam klystrons. In this project, a conceptual design for 1.3 GHz magnicons with 20 MW peak power was developed as an alternative to the klystrons, with the possibility of cutting in half the numbers of high-power tubes and associated components. Design of a conventional magnicon is described, using TM110 modes in all cavities, as well as design of a modified magnicon with a TE111 mode output cavity. The latter has the advantage of much lower surface fields than the TM110 mode, with no loss of output power or electronic efficiency.

  4. Forward instrumentation for ILC detectors

    Science.gov (United States)

    Abramowicz, H.; Abusleme, A.; Afanaciev, K.; Aguilar, J.; Ambalathankandy, P.; Bambade, P.; Bergholz, M.; Bozovic-Jelisavcic, I.; Castro, E.; Chelkov, G.; Coca, C.; Daniluk, W.; Dragone, A.; Dumitru, L.; Elsener, K.; Emeliantchik, I.; Fiutowski, T.; Gostkin, M.; Grah, C.; Grzelak, G.; Haller, G.; Henschel, H.; Ignatenko, A.; Idzik, M.; Ito, K.; Jovin, T.; Kielar, E.; Kotula, J.; Krumstein, Z.; Kulis, S.; Lange, W.; Lohmann, W.; Levy, A.; Moszczynski, A.; Nauenberg, U.; Novgorodova, O.; Ohlerich, M.; Orlandea, M.; Oleinik, G.; Oliwa, K.; Olshevski, A.; Pandurovic, M.; Pawlik, B.; Przyborowski, D.; Sato, Y.; Sadeh, I.; Sailer, A.; Schmidt, R.; Schumm, B.; Schuwalow, S.; Smiljanic, I.; Swientek, K.; Takubo, Y.; Teodorescu, E.; Wierba, W.; Yamamoto, H.; Zawiejski, L.; Zhang, J.

    2010-12-01

    Two special calorimeters are foreseen for the instrumentation of the very forward region of the ILC detector, a luminometer designed to measure the rate of low angle Bhabha scattering events with a precision better than 10-3 and a low polar angle calorimeter, adjacent to the beam-pipe. The latter will be hit by a large amount of beamstrahlung remnants. The amount and shape of these depositions will allow a fast luminosity estimate and the determination of beam parameters. The sensors of this calorimeter must be radiation hard. Both devices will improve the hermeticity of the detector in the search for new particles. Finely segmented and very compact calorimeters will match the requirements. Due to the high occupancy fast front-end electronics is needed. The design of the calorimeters developed and optimised with Monte Carlo simulations is presented. Sensors and readout electronics ASICs have been designed and prototypes are available. Results on the performance of these major components are summarised.

  5. Forward instrumentation for ILC detectors

    Energy Technology Data Exchange (ETDEWEB)

    Abramowicz, H [Tel Aviv University, Tel Aviv (Israel); Abusleme, A [Stanford University, Stanford (United States); Afanaciev, K; Emeliantchik, I [NCPHEP, Minsk (Belarus); Aguilar, J; Ambalathankandy, P; Fiutowski, T [AGH University of Science and Technology, Cracow (Poland); Bambade, P [Laboratoire de l Accelerateur Lineaire, Orsay (France); Bergholz, M; Castro, E; Grah, C [DESY, Zeuthen (Germany); Bozovic-Jelisavcic, I [Vinca Institute of Nuclear Sciences, University of Belgrade (Serbia); Chelkov, G; Gostkin, M [JINR, Dubna (Russian Federation); Coca, C; Dumitru, L [IFIN-HH, Bucharest (Romania); Daniluk, W; Grzelak, G [INP PAN, Cracow (Poland); Dragone, A [SLAC, Menlo Park (United States); Elsener, K, E-mail: Wolfgang.Lohmann@desy.d [CERN, Geneva (Switzerland)

    2010-12-15

    Two special calorimeters are foreseen for the instrumentation of the very forward region of the ILC detector, a luminometer designed to measure the rate of low angle Bhabha scattering events with a precision better than 10{sup -3} and a low polar angle calorimeter, adjacent to the beam-pipe. The latter will be hit by a large amount of beamstrahlung remnants. The amount and shape of these depositions will allow a fast luminosity estimate and the determination of beam parameters. The sensors of this calorimeter must be radiation hard. Both devices will improve the hermeticity of the detector in the search for new particles. Finely segmented and very compact calorimeters will match the requirements. Due to the high occupancy fast front-end electronics is needed. The design of the calorimeters developed and optimised with Monte Carlo simulations is presented. Sensors and readout electronics ASICs have been designed and prototypes are available. Results on the performance of these major components are summarised.

  6. Simplified SUSY at the ILC

    Energy Technology Data Exchange (ETDEWEB)

    Berggren, Mikael

    2013-08-15

    At the ILC, one has the possibility to search for SUSY in an model-independent way: The corner-stone of SUSY is that sparticles couple as particles. This is independent of the mechanism responsible for SUSY breaking. Any model will have one Lightest SUSY Particle (LSP), and one Next to Lightest SUSY Particle (NLSP). In models with conserved R-parity, the NLSP must decay solely to the LSP and the SM partner of the NLSP. Therefore, studying NLSP production and decay can be regarded as a ''simplified model without simplification'': Any SUSY model will have such a process. The NLSP could be any sparticle: a slepton, an electroweak-ino, or even a squark. However, since there are only a finite number of sparticles, one can systematically search for signals of all possible NLSP:s. This way, the entire space of models that have a kinematically reachable NLSP can be covered. For any NLSP, the ''worst case'' can be determined, since the SUSY principle allows to calculate the cross-section once the NLSP nature and mass are given. The region in the LSP-NLSP mass-plane where the ''worst case'' could be discovered or excluded experimentally can be found by estimating background and efficiency at each point in the plane. From experience at LEP, it is expected that the lower signal-to background ratio will indeed be found for models with conserved R-parity. In this document, we show that at the ILC, such a program is possible, as it was at LEP. No loop-holes are left, even for difficult or non-standard cases: whatever the NLSP is it will be detectable.

  7. The BSM Physics Case of the ILC

    CERN Document Server

    Reuter, Jürgen

    2016-01-01

    In this talk I summarize the physics case of the International Linear Collider (ILC) focusing on its potential towards discovery, discrimation or disentanglement of new physics beyond the Standard Model (BSM).

  8. The BSM physics case of the ILC

    Energy Technology Data Exchange (ETDEWEB)

    Reuter, Juergen [DESY, Hamburg (Germany). Theory Group

    2016-02-15

    In this talk I summarize the physics case of the International Linear Collider (ILC) focusing on its potential towards discovery, discrimation or disentanglement of new physics beyond the Standard Model (BSM).

  9. Intrinsic properties of mouse lumbar motoneurons revealed by intracellular recording in vivo

    DEFF Research Database (Denmark)

    Meehan, Claire Francesca; Sukiasyan, Natalya; Zhang, Mengliang;

    2010-01-01

    identified circuits in the spinal cord. Forty-one motoneurons with antidromic spike potentials (>50 mV) from the sciatic nerve were investigated. We recorded the intrinsic properties of the neurons, including input resistance (mean: 2.4 +/- 1.2 MOmega), rheobase (mean: 7.1 +/- 5.9 nA), and the duration...

  10. Respiratory neuron characterization reveals intrinsic bursting properties in isolated adult turtle brainstems (Trachemys scripta)

    Science.gov (United States)

    Johnson, Stephen M.; Hedrick, Michael S.; Krause, Bryan M.; Nilles, Jacob P.; Chapman, Mark A.

    2014-01-01

    It is not known whether respiratory neurons with intrinsic bursting properties exist within ectothermic vertebrate respiratory control systems. Thus, isolated adult turtle brainstems spontaneously producing respiratory motor output were used to identify and classify respiratory neurons based on their firing pattern relative to hypoglossal (XII) nerve activity. Most respiratory neurons (183/212) had peak activity during the expiratory phase, while inspiratory, post-inspiratory, and novel pre-expiratory neurons were less common. During synaptic blockade conditions, ~10% of respiratory neurons fired bursts of action potentials, with post-inspiratory cells (6/9) having the highest percentage of intrinsic burst properties. Most intrinsically bursting respiratory neurons were clustered at the level of the vagus (X) nerve root. Synaptic inhibition blockade caused seizure-like activity throughout the turtle brainstem, which shows that the turtle respiratory control system is not transformed into a network driven by intrinsically bursting respiratory neurons. We hypothesize that intrinsically bursting respiratory neurons are evolutionarily conserved and represent a potential rhythmogenic mechanism contributing to respiration in adult turtles. PMID:25462012

  11. Discovering intrinsic properties of human observers' visual search and mathematical observers' scanning.

    Science.gov (United States)

    He, Xin; Samuelson, Frank; Zeng, Rongping; Sahiner, Berkman

    2014-11-01

    There is a lack of consensus in measuring observer performance in search tasks. To pursue a consensus, we set our goal to obtain metrics that are practical, meaningful, and predictive. We consider a metric practical if it can be implemented to measure human and computer observers' performance. To be meaningful, we propose to discover intrinsic properties of search observers and formulate the metrics to characterize these properties. If the discovered properties allow verifiable predictions, we consider them predictive. We propose a theory and a conjecture toward two intrinsic properties of search observers: rationality in classification as measured by the location-known-exactly (LKE) receiver operating characteristic (ROC) curve and location uncertainty as measured by the effective set size (M*). These two properties are used to develop search models in both single-response and free-response search tasks. To confirm whether these properties are "intrinsic," we investigate their ability in predicting search performance of both human and scanning channelized Hotelling observers. In particular, for each observer, we designed experiments to measure the LKE-ROC curve and M*, which were then used to predict the same observer's performance in other search tasks. The predictions were then compared to the experimentally measured observer performance. Our results indicate that modeling the search performance using the LKE-ROC curve and M* leads to successful predictions in most cases.

  12. Quality and safety aspects of reusable plastic food packaging materials: influence of reuse on intrinsic properties.

    Science.gov (United States)

    Jetten, J; de, Kruijf N

    2002-01-01

    The aim of the project was to develop a comprehensive package of quality assurance criteria for use by the industry and by regulatory authorities to ensure the quality and safety-in-use (sensory, microbiological and chemical safety) of reused plastics for food packaging. The paper describes the investigations into potential adulteration effects by reuse on the intrinsic properties of plastics in more detail. The plastic articles investigated were bottles of polyethylene terephthalate (PET) or polycarbonate (PC) and vending cups of polypropylene (PP). The influence of repeated use on the migration of plastic constituents, degradation products of plastic additives, barrier properties and surface characteristics were investigated. The overall conclusion was that the investigated intrinsic properties of the refillable articles were not significantly influenced by repeated use. Only the hydrophobicity of the refillable PC and PP articles seemed to be influenced by repeated washing. PC bottles washed 15 times were significantly less hydrophobic than unwashed bottles.

  13. Forward instrumentation for ILC detectors

    Energy Technology Data Exchange (ETDEWEB)

    Abramowicz, Halina [Tel Aviv Univ. (Israel); Abusleme, Angel [Stanford Univ., CA (United States); Afanaciev, Konstantin [NCPHEP, Minsk (BY)] (and others)

    2010-09-15

    Two special calorimeters are foreseen for the instrumentation of the very forward region of the ILC detector, a luminometer designed to measure the rate of low angle Bhabha scattering events with a precision better than 10{sup -3} and a low polar angle calorimeter, adjacent to the beam-pipe. The latter will be hit by a large amount of beamstrahlung remnants. The amount and shape of these depositions will allow a fast luminosity estimate and the determination of beam parameters. The sensors of this calorimeter must be radiation hard. Both devices will improve the hermeticity of the detector in the search for new particles. Finely segmented and very compact calorimeters will match the requirements. Due to the high occupancy fast front-end electronics is needed. The design of the calorimeters developed and optimised with Monte Carlo simulations is presented. Sensors and readout electronics ASICs have been designed and prototypes are available. Results on the performance of these major components are summarised. (orig.)

  14. Characterization of intrinsic properties of cingulate pyramidal neurons in adult mice after nerve injury

    Directory of Open Access Journals (Sweden)

    Chen Tao

    2009-12-01

    Full Text Available Abstract The anterior cingulate cortex (ACC is important for cognitive and sensory functions including memory and chronic pain. Glutamatergic excitatory synaptic transmission undergo long-term potentiation in ACC pyramidal cells after peripheral injury. Less information is available for the possible long-term changes in neuronal action potentials or intrinsic properties. In the present study, we characterized cingulate pyramidal cells in the layer II/III of the ACC in adult mice. We then examined possible long-term changes in intrinsic properties of the ACC pyramidal cells after peripheral nerve injury. In the control mice, we found that there are three major types of pyramidal cells according to their action potential firing pattern: (i regular spiking (RS cells (24.7%, intrinsic bursting (IB cells (30.9%, and intermediate (IM cells (44.4%. In a state of neuropathic pain, the population distribution (RS: 21.3%; IB: 31.2%; IM: 47.5% and the single action potential properties of these three groups were indistinguishable from those in control mice. However, for repetitive action potentials, IM cells from neuropathic pain animals showed higher initial firing frequency with no change for the properties of RS and IB neurons from neuropathic pain mice. The present results provide the first evidence that, in addition to synaptic potentiation reported previously, peripheral nerve injury produces long-term plastic changes in the action potentials of cingulate pyramidal neurons in a cell type-specific manner.

  15. Intrinsic neuronal properties switch the mode of information transmission in networks.

    Directory of Open Access Journals (Sweden)

    Julijana Gjorgjieva

    2014-12-01

    Full Text Available Diverse ion channels and their dynamics endow single neurons with complex biophysical properties. These properties determine the heterogeneity of cell types that make up the brain, as constituents of neural circuits tuned to perform highly specific computations. How do biophysical properties of single neurons impact network function? We study a set of biophysical properties that emerge in cortical neurons during the first week of development, eventually allowing these neurons to adaptively scale the gain of their response to the amplitude of the fluctuations they encounter. During the same time period, these same neurons participate in large-scale waves of spontaneously generated electrical activity. We investigate the potential role of experimentally observed changes in intrinsic neuronal properties in determining the ability of cortical networks to propagate waves of activity. We show that such changes can strongly affect the ability of multi-layered feedforward networks to represent and transmit information on multiple timescales. With properties modeled on those observed at early stages of development, neurons are relatively insensitive to rapid fluctuations and tend to fire synchronously in response to wave-like events of large amplitude. Following developmental changes in voltage-dependent conductances, these same neurons become efficient encoders of fast input fluctuations over few layers, but lose the ability to transmit slower, population-wide input variations across many layers. Depending on the neurons' intrinsic properties, noise plays different roles in modulating neuronal input-output curves, which can dramatically impact network transmission. The developmental change in intrinsic properties supports a transformation of a networks function from the propagation of network-wide information to one in which computations are scaled to local activity. This work underscores the significance of simple changes in conductance parameters in

  16. Intrinsic neuronal properties switch the mode of information transmission in networks.

    Science.gov (United States)

    Gjorgjieva, Julijana; Mease, Rebecca A; Moody, William J; Fairhall, Adrienne L

    2014-12-01

    Diverse ion channels and their dynamics endow single neurons with complex biophysical properties. These properties determine the heterogeneity of cell types that make up the brain, as constituents of neural circuits tuned to perform highly specific computations. How do biophysical properties of single neurons impact network function? We study a set of biophysical properties that emerge in cortical neurons during the first week of development, eventually allowing these neurons to adaptively scale the gain of their response to the amplitude of the fluctuations they encounter. During the same time period, these same neurons participate in large-scale waves of spontaneously generated electrical activity. We investigate the potential role of experimentally observed changes in intrinsic neuronal properties in determining the ability of cortical networks to propagate waves of activity. We show that such changes can strongly affect the ability of multi-layered feedforward networks to represent and transmit information on multiple timescales. With properties modeled on those observed at early stages of development, neurons are relatively insensitive to rapid fluctuations and tend to fire synchronously in response to wave-like events of large amplitude. Following developmental changes in voltage-dependent conductances, these same neurons become efficient encoders of fast input fluctuations over few layers, but lose the ability to transmit slower, population-wide input variations across many layers. Depending on the neurons' intrinsic properties, noise plays different roles in modulating neuronal input-output curves, which can dramatically impact network transmission. The developmental change in intrinsic properties supports a transformation of a networks function from the propagation of network-wide information to one in which computations are scaled to local activity. This work underscores the significance of simple changes in conductance parameters in governing how neurons

  17. Impact of visual repetition rate on intrinsic properties of low frequency fluctuations in the visual network.

    Directory of Open Access Journals (Sweden)

    Yi-Chia Li

    Full Text Available BACKGROUND: Visual processing network is one of the functional networks which have been reliably identified to consistently exist in human resting brains. In our work, we focused on this network and investigated the intrinsic properties of low frequency (0.01-0.08 Hz fluctuations (LFFs during changes of visual stimuli. There were two main questions to be discussed in this study: intrinsic properties of LFFs regarding (1 interactions between visual stimuli and resting-state; (2 impact of repetition rate of visual stimuli. METHODOLOGY/PRINCIPAL FINDINGS: We analyzed scanning sessions that contained rest and visual stimuli in various repetition rates with a novel method. The method included three numerical approaches involving ICA (Independent Component Analyses, fALFF (fractional Amplitude of Low Frequency Fluctuation, and Coherence, to respectively investigate the modulations of visual network pattern, low frequency fluctuation power, and interregional functional connectivity during changes of visual stimuli. We discovered when resting-state was replaced by visual stimuli, more areas were involved in visual processing, and both stronger low frequency fluctuations and higher interregional functional connectivity occurred in visual network. With changes of visual repetition rate, the number of areas which were involved in visual processing, low frequency fluctuation power, and interregional functional connectivity in this network were also modulated. CONCLUSIONS/SIGNIFICANCE: To combine the results of prior literatures and our discoveries, intrinsic properties of LFFs in visual network are altered not only by modulations of endogenous factors (eye-open or eye-closed condition; alcohol administration and disordered behaviors (early blind, but also exogenous sensory stimuli (visual stimuli with various repetition rates. It demonstrates that the intrinsic properties of LFFs are valuable to represent physiological states of human brains.

  18. Intrinsic properties and mechanisms of spontaneous firing in mouse cerebellar unipolar brush cells.

    Science.gov (United States)

    Russo, Marco J; Mugnaini, Enrico; Martina, Marco

    2007-06-01

    Neuronal firing patterns are determined by the cell's intrinsic electrical and morphological properties and are regulated by synaptic interactions. While the properties of cerebellar neurons have generally been studied in much detail, little is known about the unipolar brush cells (UBCs), a type of glutamatergic interneuron that is enriched in the granular layer of the mammalian vestibulocerebellum and participates in the representation of head orientation in space. Here we show that UBCs can be distinguished from adjacent granule cells on the basis of differences in membrane capacitance, input resistance and response to hyperpolarizing current injection. We also show that UBCs are intrinsically firing neurons. Using action potential clamp experiments and whole-cell recordings we demonstrate that two currents contribute to this property: a persistent TTX-sensitive sodium current and a ruthenium red-sensitive, TRP-like cationic current, both of which are active during interspike intervals and have reversal potentials positive to threshold. Interestingly, although UBCs are also endowed with a large I(h) current, this current is not involved in their intrinsic firing, perhaps because it activates at voltages that are more hyperpolarized than those associated with autonomous activity.

  19. Effects of lanthanum substitution on microstructures and intrinsic magnetic properties of Nd-Fe-B alloy

    Institute of Scientific and Technical Information of China (English)

    李智; 刘卫强; 查善顺; 李玉卿; 王云峤; 张东涛; 岳明; 张久兴

    2015-01-01

    (Nd1–xLax)30Fe69B (x=0, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6) alloys were prepared by inducting melting, and the effect of substitution of La for Nd on their microstructure and intrinsic magnetic properties were investigated. With the increase of La content, Curie tem-perature (Tc) decreased from 582.4 to 557.4 K, saturation magnetization (Ms) decreased from 1.59 to 1.37 T, and anisotropy field (HA) decreased from 5394 to 3911 kA/m. However, the reductions of the intrinsic magnetic properties were relatively gentle as La content increased, which meant that the intrinsic magnetic properties still had the potential to fabricate permanent magnets. Moreover, further microstructure observations showed that La tended to diffuse into the Nd-rich grain boundary phase instead of main phase during the substitute process. Such aggregation behavior was beneficial to fabricating La containing magnet with high Ms.

  20. ILC Extraction Line Simulations with TDR Parameters

    CERN Document Server

    Marin, Eduardo

    2014-01-01

    The goal of this study is to evaluate the impact of the latest ILC beam parameters at the Interaction Point (IP), as specified in the 2013 ILC Technical Design Report (TDR), on beam losses in the extraction line. The previous beam loss evaluation was based on the parameters specified in the 2007 ILC Reference Design Report (RDR). The results of this study are compared to the results obtained in the past for the ``nominal'' and the ``low power'' (low-P) parameter options of the RDR. The initial disrupted beam distribution at IP was generated using Guinea-Pig code, and the beam losses were obtained in tracking simulations using DIMAD. The study is performed for 500 GeV center-of-mass beam energy and the extraction line optics corresponding to the latest final focus optics with L* = 4.5 m, with and without detector solenoid.

  1. New concept to break the intrinsic properties of organic semiconductors for optical sensing applications

    Science.gov (United States)

    Choy, Wallace C. H.

    2015-09-01

    As the intrinsic electrostatic limit, space charge limit (SCL) for photocurrent is a universal phenomenon which is fundamental important for organic semiconductors. We will demonstrate SCL breaking by a new plasmonic-electrical concept. As a proof-ofconcept, organic solar cells (OSCs) comprising metallic planar and grating electrodes are studied. Interestingly, although strong plasmonic resonances induce abnormally dense photocarriers around a grating anode, the grating incorporated inverted OSC is exempt from space charge accumulation (limit) and degradation of electrical properties. The plasmonic-electrical concept will open up a new way to manipulate both optical and electrical properties of semiconductor devices simultaneously.

  2. CMB Power Spectrum Likelihood with ILC

    CERN Document Server

    Dick, Jason; Delabrouille, Jacques

    2012-01-01

    We extend the ILC method in harmonic space to include the error in its CMB estimate. This allows parameter estimation routines to take into account the effect of the foregrounds as well as the errors in their subtraction in conjunction with the ILC method. Our method requires the use of a model of the foregrounds which we do not develop here. The reduction of the foreground level makes this method less sensitive to unaccounted for errors in the foreground model. Simulations are used to validate the calculations and approximations used in generating this likelihood function.

  3. A Human Lin(-) CD123(+) CD127(low) Population Endowed with ILC Features and Migratory Capabilities Contributes to Immunopathological Hallmarks of Psoriasis.

    Science.gov (United States)

    Mora-Velandia, Luz María; Castro-Escamilla, Octavio; Méndez, Andrés González; Aguilar-Flores, Cristina; Velázquez-Avila, Martha; Tussié-Luna, María Isabel; Téllez-Sosa, Juan; Maldonado-García, César; Jurado-Santacruz, Fermín; Ferat-Osorio, Eduardo; Martínez-Barnetche, Jesus; Pelayo, Rosana; Bonifaz, Laura C

    2017-01-01

    Innate lymphoid cells (ILC) are members of a heterogeneous family with a lymphoid origin that mimics the T helper (Th) cytokine profile. ILC are involved in early effector cytokine-mediated responses during infections in peripheral tissues. ILC also play an important role in chronic skin inflammatory diseases, including psoriasis. Although classical ILC express CD127, it has been recently reported that the presence of non-classical CD127(-) ILC populations and an early ILC precursor (EILP) CD127(low). ILC development has predominately been investigated in mouse models. However, in humans, different transcription factors have been described for ILC identification. NFIL3 (nuclear factor, IL-3 regulated) is crucial for ILC development in response to IL-7. CD123 (IL-3Rα) is usually used to exclude basophils during ILC identification, however, it is unknown if in response to IL-3, NFIL3 could be relevant to induce ILC features in Lin(-) CD123(+) populations in addition, is also unknown whether peripheral blood (PB) population with ILC features may have skin-homing potential to participate in skin inflammatory chronic diseases. Here, we report a Lin(-) CD123(+) CD127(low) CD7(+) CLA(+) population that share some phenotypic properties with basophils, but expresses several transcription factors for ILC commitment such as inhibitor of DNA binding 2 (Id2), NFIL3, promyelocytic leukemia zinc finger (PLZF), thymocyte selection-associated high-mobility group box protein (TOX), and T cell factor-1 (TCF-1). In addition, this population expresses different ILC markers: CD132, CD90, CD161, α4 integrin, c-Kit, CRTH2, AhR, and IL-23R. IL-3 prevents apoptosis and increases their NFIL3, TOX, and PLZF expression. In PB, the CD123(+) CD127(low) population is predominantly a conspicuous population that expresses T-bet and RORγt. The Lin(-) CD123(+) CD127(low) population in PB has a limited Th type cytokine expression and highly expresses IL-8. The Lin(-) CD123(+) CD127(low) population

  4. A Human Lin− CD123+ CD127low Population Endowed with ILC Features and Migratory Capabilities Contributes to Immunopathological Hallmarks of Psoriasis

    Science.gov (United States)

    Mora-Velandia, Luz María; Castro-Escamilla, Octavio; Méndez, Andrés González; Aguilar-Flores, Cristina; Velázquez-Avila, Martha; Tussié-Luna, María Isabel; Téllez-Sosa, Juan; Maldonado-García, César; Jurado-Santacruz, Fermín; Ferat-Osorio, Eduardo; Martínez-Barnetche, Jesus; Pelayo, Rosana; Bonifaz, Laura C.

    2017-01-01

    Innate lymphoid cells (ILC) are members of a heterogeneous family with a lymphoid origin that mimics the T helper (Th) cytokine profile. ILC are involved in early effector cytokine-mediated responses during infections in peripheral tissues. ILC also play an important role in chronic skin inflammatory diseases, including psoriasis. Although classical ILC express CD127, it has been recently reported that the presence of non-classical CD127− ILC populations and an early ILC precursor (EILP) CD127low. ILC development has predominately been investigated in mouse models. However, in humans, different transcription factors have been described for ILC identification. NFIL3 (nuclear factor, IL-3 regulated) is crucial for ILC development in response to IL-7. CD123 (IL-3Rα) is usually used to exclude basophils during ILC identification, however, it is unknown if in response to IL-3, NFIL3 could be relevant to induce ILC features in Lin− CD123+ populations in addition, is also unknown whether peripheral blood (PB) population with ILC features may have skin-homing potential to participate in skin inflammatory chronic diseases. Here, we report a Lin− CD123+ CD127low CD7+ CLA+ population that share some phenotypic properties with basophils, but expresses several transcription factors for ILC commitment such as inhibitor of DNA binding 2 (Id2), NFIL3, promyelocytic leukemia zinc finger (PLZF), thymocyte selection-associated high-mobility group box protein (TOX), and T cell factor-1 (TCF-1). In addition, this population expresses different ILC markers: CD132, CD90, CD161, α4 integrin, c-Kit, CRTH2, AhR, and IL-23R. IL-3 prevents apoptosis and increases their NFIL3, TOX, and PLZF expression. In PB, the CD123+ CD127low population is predominantly a conspicuous population that expresses T-bet and RORγt. The Lin− CD123+ CD127low population in PB has a limited Th type cytokine expression and highly expresses IL-8. The Lin− CD123+ CD127low population expresses skin

  5. Intrinsic electrophysiological properties of entorhinal cortex stellate cells and their contribution to grid cell firing fields

    Directory of Open Access Journals (Sweden)

    Hugh ePastoll

    2012-04-01

    Full Text Available The medial entorhinal cortex (MEC is an increasingly important focus for investigation of mechanisms for spatial representation. Grid cells found in layer II of the MEC are likely to be stellate cells, which form a major projection to the dentate gyrus. Entorhinal stellate cells are distinguished by distinct intrinsic electrophysiological properties, but how these properties contribute to representation of space is not yet clear. Here, we review the ionic conductances, synaptic and excitable properties of stellate cells, and examine their implications for models of grid firing fields. We discuss why existing data are inconsistent with models of grid fields that require stellate cells to generate periodic oscillations. An alternative possibility is that the intrinsic electrophysiological properties of stellate cells are tuned specifically to control integration of synaptic input. We highlight recent evidence that the dorsal-ventral organization of synaptic integration by stellate cells, through differences in currents mediated by HCN and leak potassium channels, influences the corresponding organization of grid fields. Because accurate cellular data will be important for distinguishing mechanisms for generation of grid fields, we introduce new data comparing properties measured with whole-cell and perforated patch-clamp recordings. We find that clustered patterns of action potential firing and the action potential after-hyperpolarization are particularly sensitive to recording condition. Nevertheless, with both methods, these properties, resting membrane properties and resonance follow a dorsal ventral organization. Further investigation of the molecular basis for synaptic integration by stellate cells will be important for understanding mechanisms for generation of grid fields.

  6. ILC Instrumentation R&D at SCIPP

    Energy Technology Data Exchange (ETDEWEB)

    Carman, J.; Crosby, S.; Fadeyev, V.; /UC, Santa Cruz; Partridge, R.; /SLAC; Schumm, B.A.; Spencer, N.; Wilder, M.; /UC, Santa Cruz

    2011-11-14

    The Santa Cruz Institute for Particle Physics (SCIPP) continues to be engaged in research and development towards an ILC detector. The latest efforts at SCIPP are described, including those associated with the LSTFE front-end readout ASIC, the use of charge division to obtain a longitudinal coordinate from silicon strip detectors, and the contribution of strip resistance to readout noise.

  7. UK pulls out of plans for ILC

    CERN Multimedia

    Durrani, Matin

    2007-01-01

    "A funding crisis at one of the UK's leading research councils has forced the country to pull out of plans for the International Linear Collider (ILC). The science and Technology Facilities Council (STFC) says in a report published today that it does not see "a practicable path towards the realization of this facility as currently conceived on a reasonable timescale". (1 page)

  8. Power coupler for the ILC crab cavity

    Energy Technology Data Exchange (ETDEWEB)

    Burt, G.; Dexter, A.; Jenkins, R.; /Lancaster U.; Beard, C.; Goudket, P.; McIntosh, P.A.; /Daresbury; Bellantoni, Leo; /Fermilab

    2007-06-01

    The ILC crab cavity will require the design of an appropriate power coupler. The beam-loading in dipole mode cavities is considerably more variable than accelerating cavities, hence simulations have been performed to establish the required external Q. Simulations of a suitable coupler were then performed and were verified using a normal conducting prototype with variable coupler tips.

  9. Dispersion stability and electrokinetic properties of intrinsic plutonium colloids: implications for subsurface transport.

    Science.gov (United States)

    Abdel-Fattah, Amr I; Zhou, Dongxu; Boukhalfa, Hakim; Tarimala, Sowmitri; Ware, S Doug; Keller, Arturo A

    2013-06-04

    Subsurface transport of plutonium (Pu) may be facilitated by the formation of intrinsic Pu colloids. While this colloid-facilitated transport is largely governed by the electrokinetic properties and dispersion stability (resistance to aggregation) of the colloids, reported experimental data is scarce. Here, we quantify the dependence of ζ-potential of intrinsic Pu(IV) colloids on pH and their aggregation rate on ionic strength. Results indicate an isoelectric point of pH 8.6 and a critical coagulation concentration of 0.1 M of 1:1 electrolyte at pH 11.4. The ζ-potential/pH dependence of the Pu(IV) colloids is similar to that of goethite and hematite colloids. Colloid interaction energy calculations using these values reveal an effective Hamaker constant of the intrinsic Pu(IV) colloids in water of 1.85 × 10(-19) J, corresponding to a relative permittivity of 6.21 and refractive index of 2.33, in agreement with first principles calculations. This relatively high Hamaker constant combined with the positive charge of Pu(IV) colloids under typical groundwater aquifer conditions led to two contradicting hypotheses: (a) the Pu(IV) colloids will exhibit significant aggregation and deposition, leading to a negligible subsurface transport or (b) the Pu(IV) colloids will associate with the relatively stable native groundwater colloids, leading to a considerable subsurface transport. Packed column transport experiments supported the second hypothesis.

  10. Energy-band structure and intrinsic coherent properties in two weakly linked Bose-Einstein condensates

    Science.gov (United States)

    Li, Wei-Dong; Zhang, Yunbo; Liang, J.-Q.

    2003-06-01

    The energy-band structure and energy splitting due to quantum tunneling in two weakly linked Bose-Einstein condensates were calculated by using the instanton method. The intrinsic coherent properties of Bose-Josephson junction (BJJ) were investigated in terms of energy splitting. For EC/EJ≪1, the energy splitting is small and the system is globally phase coherent. In the opposite limit, EC/EJ≫1, the energy splitting is large and the system becomes phase dissipated. Our results suggest that one should investigate the coherence phenomena of BJJ in proper condition such as EC/EJ˜1.

  11. Intrinsic electronic properties of high-quality wurtzite InN

    Science.gov (United States)

    Eisele, H.; Schuppang, J.; Schnedler, M.; Duchamp, M.; Nenstiel, C.; Portz, V.; Kure, T.; Bügler, M.; Lenz, A.; Dähne, M.; Hoffmann, A.; Gwo, S.; Choi, S.; Speck, J. S.; Dunin-Borkowski, R. E.; Ebert, Ph.

    2016-12-01

    Recent reports suggested that InN is a highly unusual III-V semiconductor, whose behavior fundamentally differs from that of others. We therefore analyzed its intrinsic electronic properties on the highest available quality InN layers, demonstrating the absence of electron accumulation at the (10 1 ¯0 ) cleavage surface and in the bulk. The bulk electron density is governed solely by dopants. Hence, we conclude that InN acts similarly to the other III-V semiconductors and previously reported intriguing effects are related to low crystallinity, surface decomposition, nonstoichiometry, and/or In adlayers.

  12. Frequency-domain analysis of intrinsic neuronal properties using high-resistant electrodes

    Directory of Open Access Journals (Sweden)

    Christian Rössert

    2009-08-01

    Full Text Available Intrinsic cellular properties of neurons in culture or slices are usually studied by the whole cell clamp method using low-resistant patch pipettes. These electrodes allow detailed analyses with standard electrophysiological methods such as current- or voltage-clamp. However, in these preparations large parts of the network and dendritic structures may be removed, thus preventing an adequate study of synaptic signal processing. Therefore, intact in vivo preparations or isolated in vitro whole brains have been used in which intracellular recordings are usually made with sharp, high-resistant electrodes to optimize the impalement of neurons. The general non-linear resistance properties of these electrodes, however, severely limit accurate quantitative studies of membrane dynamics especially needed for precise modelling. Therefore, we have developed a frequency-domain analysis of membrane properties that uses a Piece-wise Non-linear Electrode Compensation (PNEC method. The technique was tested in second-order vestibular neurons and abducens motoneurons of isolated frog whole brain preparations using sharp potassium chloride- or potassium acetate-filled electrodes. All recordings were performed without online electrode compensation. The properties of each electrode were determined separately after the neuronal recordings and were used in the frequency-domain analysis of the combined measurement of electrode and cell. This allowed detailed analysis of membrane properties in the frequency-domain with high-resistant electrodes and provided quantitative data that can be further used to model channel kinetics. Thus, sharp electrodes can be used for the characterization of intrinsic properties and synaptic inputs of neurons in intact brains.

  13. Altered intrinsic and synaptic properties of lumbosacral dorsal horn neurons in a mouse model of colitis.

    Science.gov (United States)

    Farrell, Kristen E; Keely, Simon; Walker, Marjorie M; Brichta, Alan M; Graham, Brett A; Callister, Robert J

    2017-08-23

    Visceral pain in inflammatory and functional gastrointestinal conditions is a major clinical problem. The exact mechanisms underlying the development of pain, during and after visceral inflammation, are unknown clinical and pre-clinical evidence that suggests plasticity within the spinal cord dorsal horn is a contributing factor. Here we use an in vivo preparation and patch-clamp electrophysiology to test whether the synaptic and intrinsic properties of superficial dorsal horn (SDH) neurons are altered 5days after the induction of mild colitis in adult male mice (i.e. during acute inflammation of the colon). Whole-cell recordings were made from lumbosacral (L6-S1) superficial dorsal horn neurons (SDH), in animals under isoflurane anesthesia. Noxious colorectal distension (CRD) was used to identify SDH neurons with colonic inputs, while stimulation of the hind paw and tail was employed to assess convergent cutaneous input. Following inflammation, a significantly increased proportion of SDH neurons received both colonic and cutaneous inputs, compared to neurons in naïve animals. In addition, the nature and magnitude of responses to CRD and cutaneous stimulation differed in inflamed animals, as was spontaneous excitatory synaptic drive. Conversely, several measures of intrinsic excitability were altered in a manner that would decrease SDH network excitability following colitis. We propose that during inflammation, sensitization of colonic afferents results in increased signaling to the SDH. This is accompanied by plasticity in SDH neurons whereby their intrinsic properties are changed to compensate for altered afferent activity. Copyright © 2017 IBRO. Published by Elsevier Ltd. All rights reserved.

  14. Intrinsic Defect Engineering of Cuprous Oxide to Enhance Electrical Transport Properties for Photovoltaic Applications

    Energy Technology Data Exchange (ETDEWEB)

    Lloyd, Michael A.; Siah, Sin-Cheng; Brandt, Riley E.; Serdy, James; Johnston, Steve W.; Lee, Yun Seog; Buonassisi, Tonio

    2014-06-08

    Intrinsic point-defect species in cuprous oxide films are manipulated based on their thermodynamic properties via the implementation of a controlled annealing process. A wide range of electrical properties is demonstrated, with a window suitable for high-quality solar cell devices. A variation of carrier concentration over two orders of magnitude is demonstrated. Minority carrier lifetime is investigated by means of microwave photoconductance decay measurements, demonstrating a strong correlation with carrier concentration. Spectrally resolved photoluminescence yields are analyzed to provide insight into lifetime limiting mechanisms as a function of Cu2O processing parameters. Hall measurements of carrier mobility and concentration are taken at room temperature to provide insight into the effect of these processing conditions on net ionized defect concentration.

  15. Active microrheology of Chaetopterus mucus determines three intrinsic lengthscales that govern material properties

    CERN Document Server

    Weigand, W J; Deheyn, D D; Morales-Sanz, A; Blair, D L; Urbach, J S; Robertson-Anderson, R M

    2016-01-01

    We characterize the scale-dependent rheological properties of mucus from the Chaetopterus marine worm and determine the intrinsic lengthscales controlling distinct rheological and structural regimes. Mucus produced by this ubiquitous filter feeder serves a host of roles including filtration, protection and trapping nutrients. The ease of clean mucus extraction coupled with similarities to human mucus rheology also make Chaetopterus mucus a potential model system for elucidating human mucus mechanics. We use optically trapped microsphere probes of 2-10 microns, to induce oscillatory strains and measure mucus stress response. We show that viscoelastic properties are highly dependent on the strain scale (l) with three distinct regimes emerging: microscale: l_110 microns. While mucus response is similar to water for l_1 indicating that probes rarely contact the mucus mesh, for l_2 the response is distinctly more viscous and independent of probe size, demonstrating that the mucus behaves as a continuum. However, t...

  16. Vacuum systems for the ILC helical undulator

    CERN Document Server

    Malyshev, O B; Clarke, J A; Bailey, I R; Dainton, J B; Malysheva, L I; Barber, D P; Cooke, P; Baynham, E; Bradshaw, T; Brummitt, A; Carr, S; Ivanyushenkov, Y; Rochford, J; Moortgat-Pick, G A

    2007-01-01

    The International Linear Collider (ILC) positron source uses a helical undulator to generate polarized photons of ∼10MeV∼10MeV at the first harmonic. Unlike many undulators used in synchrotron radiation sources, the ILC helical undulator vacuum chamber will be bombarded by photons, generated by the undulator, with energies mostly below that of the first harmonic. Achieving the vacuum specification of ∼100nTorr∼100nTorr in a narrow chamber of 4–6mm4–6mm inner diameter, with a long length of 100–200m100–200m, makes the design of the vacuum system challenging. This article describes the vacuum specifications and calculations of the flux and energy of photons irradiating the undulator vacuum chamber and considers possible vacuum system design solutions for two cases: cryogenic and room temperature.

  17. ILC Vertex Tracker R&D

    Energy Technology Data Exchange (ETDEWEB)

    Battaglia, Marco; Bussat, Jean-Marie; Contarato, Devis; Denes,Peter; Glesener, Lindsay; Greiner, Leo; Hooberman, Benjamin; Shuman,Derek; Tompkins, Lauren; Vu, Chinh; Bisello, Dario; Giubilato, Piero; Pantano, Devis; Costa, Marco; La Rosa, Alessandro; Bolla, Gino; Bortoletto, Daniela; Children, Isaac

    2007-10-01

    This document summarizes past achievements, current activities and future goals of the R&D program aimed at the design, prototyping and characterization of a full detector module, equipped with monolithic pixel sensors, matching the requirements for the Vertex Tracker at the ILC. We provide a plan of activities to obtain a demonstrator multi-layered vertex tracker equipped with sensors matching the ILC requirements and realistic lightweight ladders in FY11, under the assumption that ILC detector proto-collaborations will be choosing technologies and designs for the Vertex Tracker by that time. The R&D program discussed here started at LBNL in 2004, supported by a Laboratory Directed R&D (LDRD) grant and by funding allocated from the core budget of the LBNL Physics Division and from the Department of Physics at UC Berkeley. Subsequently additional funding has been awarded under the NSF-DOE LCRD program and also personnel have become available through collaborative research with other groups. The aim of the R&D program carried out by our collaboration is to provide a well-integrated, inclusive research effort starting from physics requirements for the ILC Vertex Tracker and addressing Si sensor design and characterization, engineered ladder design, module system issues, tracking and vertex performances and beam test validation. The broad scope of this program is made possible by important synergies with existing know-how and concurrent programs both at LBNL and at the other collaborating institutions. In particular, significant overlaps with LHC detector design, SLHC R&D as well as prototyping for the STAR upgrade have been exploited to optimize the cost per deliverable of our program. This activity is carried out as a collaborative effort together with Accelerator and Fusion Research, the Engineering and the Nuclear Science Divisions at LBNL, INFN and the Department of Physics in Padova, Italy, INFN and the Department of Physics in Torino, Italy and the Department

  18. Primary structure and solution conditions determine conformational ensemble properties of intrinsically disordered proteins

    Science.gov (United States)

    Mao, Hsuan-Han Alberto

    Intrinsically disordered proteins (IDPs) are a class of proteins that do not exhibit well-defined three-dimensional structures. The absence of structure is intrinsic to their amino acid sequences, which are characterized by low hydrophobicity and high net charge per residue compared to folded proteins. Contradicting the classic structure-function paradigm, IDPs are capable of interacting with high specificity and affinity, often acquiring order in complex with protein and nucleic acid binding partners. This phenomenon is evident during cellular activities involving IDPs, which include transcriptional and translational regulation, cell cycle control, signal transduction, molecular assembly, and molecular recognition. Although approximately 30% of eukaryotic proteomes are intrinsically disordered, the nature of IDP conformational ensembles remains unclear. In this dissertation, we describe relationships connecting characteristics of IDP conformational ensembles to their primary structures and solution conditions. Using molecular simulations and fluorescence experiments on a set of base-rich IDPs, we find that net charge per residue segregates conformational ensembles along a globule-to-coil transition. Speculatively generalizing this result, we propose a phase diagram that predicts an IDP's average size and shape based on sequence composition and use it to generate hypotheses for a broad set of intrinsically disordered regions (IDRs). Simulations reveal that acid-rich IDRs, unlike their oppositely charged base-rich counterparts, exhibit disordered globular ensembles despite intra-chain repulsive electrostatic interactions. This apparent asymmetry is sensitive to simulation parameters for representing alkali and halide salt ions, suggesting that solution conditions modulate IDP conformational ensembles. We refine the ion parameters using a calibration procedure that relies exclusively on crystal lattice properties. Simulations with these parameters recover swollen

  19. Impact of intrinsic localized modes of atomic motion on materials properties

    Energy Technology Data Exchange (ETDEWEB)

    Manley, M E

    2010-01-20

    Recent neutron and x-ray scattering measurements show intrinsic localized modes (ILMs) in metallic uranium and ionic sodium iodide. Here, the role ILMs play in the behavior of these materials is examined. With the thermal activation of ILMs, thermal expansion is enhanced, made more anisotropic, and, at a microscopic level, becomes inhomogeneous. Interstitial diffusion, ionic conductivity, the annealing rate of radiation damage, and void growth are all influenced by ILMs. The lattice thermal conductivity is suppressed above the ILM activation temperature while no impact is observed in the electrical conductivity. This complement of transport properties suggests that ILMs could improve thermoelectric performance. Ramifications also include thermal ratcheting, a transition from brittle to ductile fracture, and possibly a phase transformation in uranium.

  20. Collective dynamics of actomyosin cortex endow cells with intrinsic mechanosensing properties

    CERN Document Server

    Étienne, Jocelyn; Fouchard, Jonathan; Bufi, Nathalie; Durand-Smet, Pauline; Asnacios, Atef

    2014-01-01

    Living cells adapt and respond actively to the mechanical properties of their environment. In addition to biochemical mechanotransduction, evidence exists for a myosin-dependent, purely mechanical sensitivity to the stiffness of the surroundings at the scale of the whole cell. Using a minimal model of the dynamics of actomyosin cortex, we show that the interplay of myosin power strokes with the rapidly remodelling actin network results in a regulation of force and cell shape that adapts to the stiffness of the environment. Instantaneous changes of the environment stiffness are found to trigger an intrinsic mechanical response of the actomyosin cortex. Cortical retrograde flow resulting from actin polymerisation at the edges is shown to be modulated by the stress resulting from myosin contractility, which in turn regulates the cell size in a force-dependent manner. The model describes the maximum force that cells can exert and the maximum speed at which they can contract, which are measured experimentally. The...

  1. Fatigue properties and intrinsic mechanism for the environmental-friendly piezoelectric materials for actuator applications

    Directory of Open Access Journals (Sweden)

    TIAN Chengyue

    2015-08-01

    Full Text Available Development of environmental-friendly lead-free piezoelectric ceramics with both large strain response and fatigue-resistant properties attracted much attention.In this work,A ternary solid solution (0.935-xBi0.5Na0.5TiO3-0.065BaTiO3-xSrTiO3(BNBSTx,reported in our previous work,that exhibits a large strain response at a critical composition,was investigated with the emphasis on its fatigue behavior.The results indicated that BNBST exhibited almost fatigue-resistant behavior after 106 cycles.The intrinsic mechanism was also discussed based on the complex impedance spectrum which was suggested to be originated from the lower defect density.

  2. Nicotinic acetylcholine receptor agonist attenuates ILC2-dependent airway hyperreactivity

    Science.gov (United States)

    Galle-Treger, Lauriane; Suzuki, Yuzo; Patel, Nisheel; Sankaranarayanan, Ishwarya; Aron, Jennifer L.; Maazi, Hadi; Chen, Lin; Akbari, Omid

    2016-01-01

    Allergic asthma is a complex and chronic inflammatory disorder that is associated with airway hyperreactivity (AHR) and driven by Th2 cytokine secretion. Type 2 innate lymphoid cells (ILC2s) produce large amounts of Th2 cytokines and contribute to the development of AHR. Here, we show that ILC2s express the α7-nicotinic acetylcholine receptor (α7nAChR), which is thought to have an anti-inflammatory role in several inflammatory diseases. We show that engagement of a specific agonist with α7nAChR on ILC2s reduces ILC2 effector function and represses ILC2-dependent AHR, while decreasing expression of ILC2 key transcription factor GATA-3 and critical inflammatory modulator NF-κB, and reducing phosphorylation of upstream kinase IKKα/β. Additionally, the specific α7nAChR agonist reduces cytokine production and AHR in a humanized ILC2 mouse model. Collectively, our data suggest that α7nAChR expressed by ILC2s is a potential therapeutic target for the treatment of ILC2-mediated asthma. PMID:27752043

  3. Intrinsic magnetic properties of L1{sub 0} FeNi obtained from meteorite NWA 6259

    Energy Technology Data Exchange (ETDEWEB)

    Poirier, Eric [MEDA Engineering and Technical Services, Southfield, Michigan 48075 (United States); Pinkerton, Frederick E., E-mail: frederick.e.pinkerton@gm.com; Kubic, Robert; Mishra, Raja K. [Chemical Sciences and Materials Systems Lab, GM R and D Center, Warren, Michigan 48090 (United States); Bordeaux, Nina; Lewis, Laura H. [Department of Chemical Engineering, Northeastern University, Boston, Massachusetts 02115 (United States); Mubarok, Arif; Goldstein, Joseph I. [Department of Mechanical and Industrial Engineering, University of Massachusetts, Amherst, Massachusetts 01003 (United States); Skomski, Ralph [Department of Physics and Astronomy, University of Nebraska, Lincoln, Nebraska 68588 (United States); Barmak, Katayun [Department of Applied Physics and Applied Mathematics, Columbia University, New York, New York 10027 (United States)

    2015-05-07

    FeNi having the tetragonal L1{sub 0} crystal structure is a promising new rare-earth-free permanent magnet material. Laboratory synthesis is challenging, however, tetragonal L1{sub 0} FeNi—the mineral “tetrataenite”—has been characterized using specimens found in nickel-iron meteorites. Most notably, the meteorite NWA 6259 recovered from Northwest Africa is 95 vol. % tetrataenite with a composition of 43 at. % Ni. Hysteresis loops were measured as a function of sample orientation on a specimen cut from NWA 6259 in order to rigorously deduce the intrinsic hard magnetic properties of its L1{sub 0} phase. Electron backscatter diffraction showed that NWA 6259 is strongly textured, containing L1{sub 0} grains oriented along any one of the three equivalent cubic directions of the parent fcc structure. The magnetic structure was modeled as a superposition of the three orthonormal uniaxial variants. By simultaneously fitting first-quadrant magnetization data for 13 different orientations of the sample with respect to the applied field direction, the intrinsic magnetic properties were estimated to be saturation magnetization 4πM{sub s} = 14.7 kG and anisotropy field H{sub a} = 14.4 kOe. The anisotropy constant K = 0.84 MJ/m{sup 3} is somewhat smaller than the value K = 1.3 MJ/m{sup 3} obtained by earlier researchers from nominally equiatomic FeNi prepared by neutron irradiation accompanied by annealing in a magnetic field, suggesting that higher Ni content (fewer Fe antisite defects) may improve the anisotropy. The fit also indicated that NWA 6259 contains one dominant variant (62% by volume), the remainder of the sample being a second variant, and the third variant being absent altogether.

  4. Intrinsic magnetic properties of L1(0) FeNi obtained from meteorite NWA 6259

    Energy Technology Data Exchange (ETDEWEB)

    Poirier, E; Pinkerton, FE; Kubic, R; Mishra, RK; Bordeaux, N; Mubarok, A; Lewis, LH; Goldstein, JI; Skomski, R; Barmak, K

    2015-05-07

    FeNi having the tetragonal L1(0) crystal structure is a promising new rare-earth-free permanent magnet material. Laboratory synthesis is challenging, however, tetragonal L1(0) FeNi-the mineral "tetrataenite"-has been characterized using specimens found in nickel-iron meteorites. Most notably, the meteorite NWA 6259 recovered from Northwest Africa is 95 vol.% tetrataenite with a composition of 43 at.% Ni. Hysteresis loops were measured as a function of sample orientation on a specimen cut from NWA 6259 in order to rigorously deduce the intrinsic hard magnetic properties of its L1(0) phase. Electron backscatter diffraction showed that NWA 6259 is strongly textured, containing L1(0) grains oriented along any one of the three equivalent cubic directions of the parent fcc structure. The magnetic structure was modeled as a superposition of the three orthonormal uniaxial variants. By simultaneously fitting first-quadrant magnetization data for 13 different orientations of the sample with respect to the applied field direction, the intrinsic magnetic properties were estimated to be saturation magnetization 4 pi M-s = 14.7 kG and anisotropy field H-a = 14.4 kOe. The anisotropy constant K = 0.84 MJ/m(3) is somewhat smaller than the value K = 1.3 MJ/m(3) obtained by earlier researchers from nominally equiatomic FeNi prepared by neutron irradiation accompanied by annealing in a magnetic field, suggesting that higher Ni content (fewer Fe antisite defects) may improve the anisotropy. The fit also indicated that NWA 6259 contains one dominant variant (62% by volume), the remainder of the sample being a second variant, and the third variant being absent altogether. (C) 2015 AIP Publishing LLC.

  5. Non-Simplified SUSY: Stau-Coannihilation at LHC and ILC

    CERN Document Server

    Berggren, M; Krücker, D; List, J; Melzer-Pellmann, I A; Samani, B Safarzadeh; Seitz, C; Wayand, S

    2015-01-01

    If new phenomena beyond the Standard Model will be discovered at the LHC, the properties of the new particles could be determined with data from the High-Luminosity LHC and from a future linear collider like the ILC. We discuss the possible interplay between measurements at the two accelerators in a concrete example, namely a full SUSY model which features a small stau_1-LSP mass difference. Various channels have been studied using the Snowmass 2013 combined LHC detector implementation in the Delphes simulation package, as well as simulations of the ILD detector concept from the Technical Design Report. We investigate both the LHC and ILC capabilities for discovery, separation and identification of various parts of the spectrum. While some parts would be discovered at the LHC, there is substantial room for further discoveries at the ILC. We finally highlight examples where the precise knowledge about the lower part of the mass spectrum which could be acquired at the ILC would enable a more in-depth analysis o...

  6. Non-simplified SUSY. τ-coannihilation at LHC and ILC

    Energy Technology Data Exchange (ETDEWEB)

    Berggren, M.; Kruecker, D.; List, J.; Melzer-Pellmann, I.A.; Seitz, C. [DESY, Hamburg (Germany); Cakir, A. [DESY, Hamburg (Germany); Istanbul Technical University, Department of Physics Engineering, Istanbul (Turkey); Samani, B.S. [DESY, Hamburg (Germany); IPM, P.O. Box 19395-5531, Tehran (Iran, Islamic Republic of); Wayand, S. [KIT IEKP, Karlsruhe (Germany)

    2016-04-15

    If new phenomena beyond the Standard Model will be discovered at the LHC, the properties of the new particles could be determined with data from the High-Luminosity LHC and from a future linear collider like the ILC. We discuss the possible interplay between measurements at the two accelerators in a concrete example, namely a full SUSY model which features a small τ-LSP mass difference. Various channels have been studied using the Snowmass 2013 combined LHC detector implementation in the Delphes simulation package, as well as simulations of the ILD detector concept from the Technical Design Report. We investigate both the LHC and the ILC capabilities for discovery, separation and identification of various parts of the spectrum. While some parts would be discovered at the LHC, there is substantial room for further discoveries at the ILC. We finally highlight examples where the precise knowledge about the lower part of the mass spectrum which could be acquired at the ILC would enable a more in-depth analysis of the LHC data with respect to the heavier states. (orig.)

  7. ILC Reference Design Report: Accelerator Executive Summary

    Energy Technology Data Exchange (ETDEWEB)

    Phinney, Nan; /SLAC

    2007-12-14

    The International Linear Collider (ILC) is a 200-500 GeV center-of-mass high-luminosity linear electron-positron collider, based on 1.3 GHz superconducting radiofrequency (SCRF) accelerating cavities. The use of the SCRF technology was recommended by the International Technology Recommendation Panel (ITRP) in August 2004 [1], and shortly thereafter endorsed by the International Committee for Future Accelerators (ICFA). In an unprecedented milestone in high-energy physics, the many institutes around the world involved in linear collider R&D united in a common effort to produce a global design for the ILC. In November 2004, the 1st International Linear Collider Workshop was held at KEK, Tsukuba, Japan. The workshop was attended by some 200 accelerator physicists from around the world, and paved the way for the 2nd ILC Workshop in August 2005, held at Snowmass, Colorado, USA, where the ILC Global Design Effort (GDE) was officially formed. The GDE membership reflects the global nature of the collaboration, with accelerator experts from all three regions (Americas, Asia and Europe). The first major goal of the GDE was to define the basic parameters and layout of the machine--the Baseline Configuration. This was achieved at the first GDE meeting held at INFN, Frascati, Italy in December 2005 with the creation of the Baseline Configuration Document (BCD). During the next 14 months, the BCD was used as the basis for the detailed design work and value estimate (as described in section 1.6) culminating in the completion of the second major milestone, the publication of the draft ILC Reference Design Report (RDR). The technical design and cost estimate for the ILC is based on two decades of world-wide Linear Collider R&D, beginning with the construction and operation of the SLAC Linear Collider (SLC). The SLC is acknowledged as a proof-of-principle machine for the linear collider concept. The ILC SCRF linac technology was pioneered by the TESLA collaboration*, culminating in

  8. Photoluminescent properties of SPAN-80 coated intrinsic and extrinsic ZnO nanostructures

    Science.gov (United States)

    Kavita; Kumar, Dinesh; Singh, Karamjit; Kumar, Sunil; Bhatti, H. S.

    2016-05-01

    Semiconductor nanostructures catch the attention due to morphology tunable properties. SPAN-80-Capped intrinsic and extrinsic ZnO nanostructures have been synthesized by the simple wet-chemical synthesis route. Structural behavior (morphology and crystallography) and photoluminescence performance of synthesized nanomaterials have been explored as a function of variable SPAN-80 concentration (0.05-0.125%). Crystallographic studies reveal that the prepared products possess wurtzite structure. Electron microscopy infers that the quantum dots are bunched together to form multifaceted morphology for 0.05% SPAN-80 concentration, whereas rectangular shape has been observed for extreme capping concentration. Photoluminescence properties have affected drastically with the introduction of SPAN-80 during the precipitation reaction. Photoluminescent properties of the synthesized nanostructures are strongly dependent on SPAN-80 concentration. Augmentation of capping concentration from 0.05% to 0.075% diminishes the luminescence quantum yield due to increased surface passivation whereas further addition of capping agent beyond the optimum capping concentration (0.075%) enhances the PL intensity due to increased energy transfer from capping shell to the nanostructure core.

  9. Characterisation and application of radiation hard sensors for LHC and ILC

    Energy Technology Data Exchange (ETDEWEB)

    Novgorodova, Olga

    2013-11-15

    The Large Hadron Collider (LHC) currently in operation intends to explore particle physics on the TeV scale. The International Linear Collider (ILC) and the Compact Linear Collider (CLIC) are being designed to measure the properties of particles discovered at the LHC with higher precision. Very forward detector systems at these machines are needed for the precise measurement of the luminosity and to approach full polar angle overage. In the current detector concepts for linear collider two electromagnetic calorimeters, Beam Calorimeter (BeamCal) and Luminosity Calorimeter (LumiCal), are foreseen. Both calorimeters are designed as sandwich calorimeters with tungsten absorber layers instrumented with finely segmented sensors. Due to a large amount of beamstrahlung remnants hitting BeamCal at the innermost radii, the sensors must withstand up to 1 MGy radiation dose per year. In this thesis two types of sensor materials were investigated: single crystal chemical vapour deposition diamonds (scCVDD) and gallium arsenide doped by chromium (GaAs:Cr). The very forward calorimeters ensure coverage for high energy electrons, positrons and photons down to very low polar angles. Within this thesis, simulation studies are presented for different beam parameters of the ILC. A new sensor segmentation was proposed to achieve better reconstruction efficiency of single high-energy electrons, positrons and photons on top of the beamstrahlung background. Only for a few years ago polycrystalline diamond sensors have been used for beam diagnostics in high-energy physics experiments. The Compact Muon Solenoid experiment, CMS, at the LHC is instrumented with several detectors for the Beam Conditions and Radiation Monitoring. The Fast Beam Conditions Monitor (BCM1F) is part of these systems. Here for the first time single crystal diamond sensors have been used. Eight detectors, comprising each a single crystal sensor and front-end electronics, are positioned around the beam pipe on both

  10. Intrinsic membrane properties underlying spontaneous tonic firing in neostriatal cholinergic interneurons.

    Science.gov (United States)

    Bennett, B D; Callaway, J C; Wilson, C J

    2000-11-15

    Neostriatal cholinergic interneurons produce spontaneous tonic firing in the absence of synaptic input. Perforated patch recording and whole-cell recording combined with calcium imaging were used in vitro to identify the intrinsic membrane properties underlying endogenous excitability. Spontaneous firing was driven by the combined action of a sodium current and the hyperpolarization-activated cation current (I(h)), which together ensured that there was no zero current point in the subthreshold voltage range. Blockade of sodium channels or I(h) established a stable subthreshold resting membrane potential. A tetrodotoxin-sensitive region of negative slope conductance was observed between approximately -60 mV and threshold (approximately -50 mV) and the h-current was activated at all subthreshold voltages. Calcium imaging experiments revealed that there was minimal calcium influx at subthreshold membrane potentials but that action potentials produced elevations of calcium in both the soma and dendrites. Spike-triggered calcium entry shaped the falling phase of the action potential waveform and activated calcium-dependent potassium channels. Blockade of big-conductance channels caused spike broadening. Application of apamin, which blocks small-conductance channels, abolished the slow spike afterhyperpolarization (AHP) and caused a transition to burst firing. In the absence of synaptic input, a range of tonic firing patterns are observed, suggesting that the characteristic spike sequences described for tonically active cholinergic neurons (TANs) recorded in vivo are intrinsic in origin. The pivotal role of the AHP in regulating spike patterning indicates that burst firing of TANs in vivo could arise from direct or indirect modulation of the AHP without requiring phasic synaptic input.

  11. Evolution, Interaction, and Intrinsic Properties of Dislocations in Intermetallics: Anisotropic 3D Dislocation Dynamics Approach

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Qian [Iowa State Univ., Ames, IA (United States)

    2008-01-01

    The generation, motion, and interaction of dislocations play key roles during the plastic deformation process of crystalline solids. 3D Dislocation Dynamics has been employed as a mesoscale simulation algorithm to investigate the collective and cooperative behavior of dislocations. Most current research on 3D Dislocation Dynamics is based on the solutions available in the framework of classical isotropic elasticity. However, due to some degree of elastic anisotropy in almost all crystalline solids, it is very necessary to extend 3D Dislocation Dynamics into anisotropic elasticity. In this study, first, the details of efficient and accurate incorporation of the fully anisotropic elasticity into 3D discrete Dislocation Dynamics by numerically evaluating the derivatives of Green's functions are described. Then the intrinsic properties of perfect dislocations, including their stability, their core properties and disassociation characteristics, in newly discovered rare earth-based intermetallics and in conventional intermetallics are investigated, within the framework of fully anisotropic elasticity supplemented with the atomistic information obtained from the ab initio calculations. Moreover, the evolution and interaction of dislocations in these intermetallics as well as the role of solute segregation are presented by utilizing fully anisotropic 3D dislocation dynamics. The results from this work clearly indicate the role and the importance of elastic anisotropy on the evolution of dislocation microstructures, the overall ductility and the hardening behavior in these systems.

  12. Noradrenergic Modulation of Intrinsic and Synaptic Properties of Lumbar Motoneurons in the Neonatal Rat Spinal Cord

    Science.gov (United States)

    Tartas, Maylis; Morin, France; Barrière, Grégory; Goillandeau, Michel; Lacaille, Jean-Claude; Cazalets, Jean-René; Bertrand, Sandrine S.

    2009-01-01

    Although it is known that noradrenaline (NA) powerfully controls spinal motor networks, few data are available regarding the noradrenergic (NAergic) modulation of intrinsic and synaptic properties of neurons in motor networks. Our work explores the cellular basis of NAergic modulation in the rat motor spinal cord. We first show that lumbar motoneurons express the three classes of adrenergic receptors at birth. Using patch-clamp recordings in the newborn rat spinal cord preparation, we characterized the effects of NA and of specific agonists of the three classes of adrenoreceptors on motoneuron membrane properties. NA increases the motoneuron excitability partly via the inhibition of a KIR like current. Methoxamine (α1), clonidine (α2) and isoproterenol (β) differentially modulate the motoneuron membrane potential but also increase motoneuron excitability, these effects being respectively inhibited by the antagonists prazosin (α1), yohimbine (α2) and propranolol (β). We show that the glutamatergic synaptic drive arising from the T13-L2 network is enhanced in motoneurons by NA, methoxamine and isoproterenol. On the other hand, NA, isoproterenol and clonidine inhibit both the frequency and amplitude of miniature glutamatergic EPSCs while methoxamine increases their frequency. The T13-L2 synaptic drive is thereby differentially modulated from the other glutamatergic synapses converging onto motoneurons and enhanced by presynaptic α1 and β receptor activation. Our data thus show that the NAergic system exerts a powerful and complex neuromodulation of lumbar motor networks in the neonatal rat spinal cord. PMID:20300468

  13. Noradrenergic modulation of intrinsic and synaptic properties of lumbar motoneurons in the neonatal rat spinal cord

    Directory of Open Access Journals (Sweden)

    Maylis Tartas

    2010-03-01

    Full Text Available Although it is known that noradrenaline powerfully controls spinal motor networks, few data are available regarding the noradrenergic modulation of intrinsic and synaptic properties of neurons in motor networks. Our work explores the cellular basis of noradrenergic modulation in the rat motor spinal cord. We first show that lumbar motoneurons express the three classes of adrenergic receptors at birth. Using patch-clamp recordings in the newborn rat spinal cord preparation, we characterized the effects of noradrenaline and of specific agonists of the three classes of adrenoreceptors on motoneuron membrane properties. Noradrenaline increases the motoneuron excitability partly via the inhibition of a KIR like current. Methoxamine (α1, clonidine (α2 and isoproterenol (β differentially modulate the motoneuron membrane potential but also increase motoneuron excitability, these effects being respectively inhibited by the antagonists prazosin (α1, yohimbine (α2 and propranolol (β. We show that the glutamatergic synaptic drive arising from the T13-L2 network is enhanced in motoneurons by noradrenaline, methoxamine and isoproterenol. On the other hand, noradrenaline, isoproterenol and clonidine inhibit both the frequency and amplitude of miniature glutamatergic EPSCs while methoxamine increases their frequency. The T13-L2 synaptic drive is thereby differentially modulated from the other glutamatergic synapses converging onto motoneurons and enhanced by presynaptic α1 and β receptor activation. Our data thus show that the noradrenergic system exerts a powerful and complex neuromodulation of lumbar motor networks in the neonatal rat spinal cord.

  14. Synchrony in Parkinson’s disease: Importance of intrinsic properties of the external globus pallidus

    Directory of Open Access Journals (Sweden)

    Bettina C. Schwab

    2013-10-01

    Full Text Available The mechanisms for the emergence and transmission of synchronized oscillations in Parkinson’s disease, which are potentially causal to motor deficits, remain debated. Aside from the motor cortex and the subthalamic nucleus, the external globus pallidus (GPe has been shown to be essential for the maintenance of these oscillations and plays a major role in sculpting neural network activity in the basal ganglia (BG. While neural activity of the healthy GPe shows almost no correlations between pairs of neurons, prominent synchronization in the β frequency band arises after dopamine depletion. Several studies have proposed that this shift is due to network interactions between the different BG nuclei, including the GPe. However, recent studies demonstrate an important role for the properties of neurons within the GPe.In this review, we will discuss these intrinsic GPe properties and review proposed mechanisms for activity decorrelation within the dopamine-intact GPe. Failure of the GPe to desynchronize correlated inputs can be a possible explanation for synchronization in the whole BG. Potential triggers of synchronization involve the enhancement of GPe-GPe inhibition and changes in ion channel function in GPe neurons.

  15. Superhydrophobic SAM Modified Electrodes for Enhanced Current Limiting Properties in Intrinsic Conducting Polymer Surge Protection Devices.

    Science.gov (United States)

    Jabarullah, Noor H; Verrelli, Emanuele; Mauldin, Clayton; Navarro, Luis A; Golden, Josh H; Madianos, Leonidas M; Kemp, Neil T

    2015-06-09

    Surface interface engineering using superhydrophobic gold electrodes made with 1-dodecanethiol self-assembled monolayer (SAM) has been used to enhance the current limiting properties of novel surge protection devices based on the intrinsic conducting polymer, polyaniline doped with methanesulfonic acid. The resulting devices show significantly enhanced current limiting characteristics, including current saturation, foldback, and negative differential effects. We show how SAM modification changes the morphology of the polymer film directly adjacent to the electrodes, leading to the formation of an interfacial compact thin film that lowers the contact resistance at the Au-polymer interface. We attribute the enhanced current limiting properties of the devices to a combination of lower contact resistance and increased Joule heating within this interface region which during a current surge produces a current blocking resistive barrier due to a thermally induced dedoping effect caused by the rapid diffusion of moisture away from this region. The effect is exacerbated at higher applied voltages as the higher temperature leads to stronger depletion of charge carriers in this region, resulting in a negative differential resistance effect.

  16. Building on the Legacy of Professor Keenan. Entropy An Intrinsic Property of Matter

    Science.gov (United States)

    Gyftopoulos, Elias P.

    2008-08-01

    In the scientific and engineering literature, entropy—the distinguishing feature of thermodynamics from other branches of physics—is viewed with skepticism, and thought to be not a physical property of matter—like mass or energy—but a measure either of disorder in a system, or of lack of information about the physics of a system in a thermodynamic equilibrium state, and a plethora of expressions are proposed for its analytical representation. In this article, I present briefly two revolutionary nonstatistical expositions of thermodynamics (revolutionary in the sense of Thomas Kuhn, The Structure of Scientific Revolutions, U. Chicago Press, 1970) that apply to all systems (both macroscopic and microscopic, including one spin or a single particle), to all states (thermodynamic equilibrium, and not thermodynamic equilibrium), and that disclose entropy as an intrinsic property of matter. The first theory is presented without reference to quantum mechanics even though quantum theoretic ideas are lurking behind the exposition. The second theory is a unified quantum theory of mechanics and thermodynamics without statistical probabilities, that is, I am not presenting another version of statistical quantum mechanics.

  17. Bilinear R parity violation at the ILC. Neutrino physics at colliders

    Energy Technology Data Exchange (ETDEWEB)

    List, J. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Vormwald, B. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Hamburg Univ. (Germany). Inst. fuer Experimentalphysik

    2013-07-15

    Supersymmetry (SUSY) with bilinearly broken R parity (bRPV) offers an attractive possibility to explain the origin of neutrino masses and mixings. Thereby neutralinos become a probe to the neutrino sector since studying neutralino decays gives access to neutrino parameters at colliders. We present the study of a bRPV SUSY model at the International Linear Collider (ILC), with the bRPV parameters determined from current neutrino data. The ILC offers a very clean environment to study the neutralino properties as well as their subsequent decays, which typically involve a W/Z and a lepton. This study is based on ILC beam parameters according to the Technical Design Report for a center of mass energy of 500 GeV. Full detector simulation of the International Large Detector (ILD) was performed for SUSY and Standard Model processes. We show for the fully simulated example point that the {chi}{sup 0}{sub 1} mass can be reconstructed with an uncertainty of less than 0.2% for an integrated luminosity of 100 fb{sup -1} from direct {chi}{sup 0}{sub 1} pair production, thus to a large extent independently of the rest of the SUSY spectrum. We also demonstrate that the achievable precision on the atmospheric neutrino mixing angle sin{sup 2} {theta}{sub 23} from measuring the neutralino branching fractions BR({chi}{sup 0}{sub 1}{yields}W{mu}) and BR({chi}{sup 0}{sub 1}{yields}W{tau}) at the ILC is comparable to current uncertainties from neutrino experiments. Thus the ILC could have the opportunity to unveil the mechanism of neutrino mass generation.

  18. Photoproduction of heavy quarkonium at the ILC

    Science.gov (United States)

    Chen, Gu; Wu, Xing-Gang; Fu, Hai-Bing; Han, Hua-Yong; Sun, Zhan

    2014-08-01

    We study the photoproduction of the heavy quarkonium at the future International Linear Collider (ILC) within the nonrelativistic QCD theory. We focus on the production channel via the subprocess γγ→|[Q1(n)⟩+Q'+Q¯, where Q and Q' stand for the heavy c or b quark, respectively. |[Q Q1(n)⟩ stands for the color-singlet S-wave quarkonium, i.e., ηc(|[c1(S10)⟩), J/ψ(|[cc¯]1(S31)⟩), Bc(|[c1(S10)⟩), Bc*(|[cb¯]1(S31)⟩), ηb(|[b1(1S0)⟩), and Υ(|[bb¯]1(S31)⟩), respectively. To improve the calculation efficiency, we adopt the improved helicity amplitude approach to deal with the difficulty of calculating the expressions for the yields when the quark masses cannot be neglected. Total and differential photoproduction cross sections, together with their uncertainties, have been presented. It is noted that a sizable number of |cc¯⟩-charmonium and |cb¯⟩-quarkonium events can be generated at the ILC. More specifically, we predict (2.4-0.6+0.8)×106 ηc, (4.7-1.1+1.6)×106 J/ψ, (8.6-1.9+2.3)×103 Bc, (4.6-0.9+1.3)×104 Bc*, (6.6±1.2)×103 ηb, and (1.2±0.2)×103 ϒ events to be generated in one operation year at the ILC under the condition of √S =500 GeV and L ≃1036 cm-2s-1.

  19. The International Linear Collider ILC a Status Report

    CERN Document Server

    Heuer, R D

    2006-01-01

    Many key questions in particle physics and cosmology are unanswered today. Accelerator experiments together with astro(particle)physics observations can shed light on these questions. Together with the LHC the ILC will play a crucial role. This contribution deals with the ILC project comprising physics case, detector studies and accelerator development.

  20. The International Linear Collider ILC - a Status Report

    Energy Technology Data Exchange (ETDEWEB)

    Heuer, R.-D. [Institut fuer Experimentalphysik, Hamburg University, Hamburg (Germany)

    2006-04-15

    Many key questions in particle physics and cosmology are unanswered today. Accelerator experiments together with astro(particle)physics observations can shed light on these questions. Together with the LHC the ILC will play a crucial role. This contribution deals with the ILC project comprising physics case, detector studies and accelerator development.

  1. Dark sector spectroscopy at the ILC

    Energy Technology Data Exchange (ETDEWEB)

    Andersen, Jeppe R.; Spannowsky, Michael [Durham University, Department of Physics, Institute for Particle Physics Phenomenology, Durham (United Kingdom); Rauch, Michael [Karlsruhe Institute of Technology (KIT), Institute for Theoretical Physics, Karlsruhe (Germany)

    2014-06-15

    Recent studies have shown that searches in the mono-photon and missing energy final state can be used to discover dark matter candidates at the ILC. While an excess in this final state over the Standard Model background would indicate the existence of a dark sector, no detailed information about the internal structure of this sector can be inferred. Here, we demonstrate how just a few observables can discriminate between various realisations of dark sectors, including e.g. the spin of mediators. (orig.)

  2. Neuronal intrinsic properties shape naturally-evoked sensory inputs in the dorsal horn of the spinal cord

    Directory of Open Access Journals (Sweden)

    Cecilia eReali

    2013-12-01

    Full Text Available Intrinsic electrophysiological properties arising from specific combinations of voltage-gated channels are fundamental for the performance of small neural networks in invertebrates, but their role in large-scale vertebrate circuits remains controversial. Although spinal neurons have complex intrinsic properties, some tasks produce high-conductance states that override intrinsic conductances, minimizing their contribution to network function. Because the detection and coding of somato-sensory information at early stages probably involves a relatively small number of neurons, we speculated that intrinsic electrophysiological properties are likely involved in the processing of sensory inputs by dorsal horn neurons (DHN. To test this idea, we took advantage of an integrated spinal cord–hindlimbs preparation from turtles allowing the combination of patch-clamp recordings of DHN embedded in an intact network, with accurate control of the extracellular milieu. We found that plateau potentials and low threshold spikes (LTS -mediated by L- and T-type Ca2+ channels, respectively- generated complex dynamics by interacting with naturally evoked synaptic potentials. Inhibitory receptive fields could be changed in sign by activation of the LTS. On the other hand, the plateau potential transformed sensory signals in the time domain by generating persistent activity triggered on and off by brief sensory inputs and windup of the response to repetitive sensory stimulation. Our findings suggest that intrinsic properties dynamically shape sensory inputs and thus represent a major building block for sensory processing by DHN. Intrinsic conductances in DHN appear to provide a mechanism for plastic phenomena such as dynamic receptive fields and sensitization to pain.

  3. Spatiotemporal memory is an intrinsic property of networks of dissociated cortical neurons.

    Science.gov (United States)

    Ju, Han; Dranias, Mark R; Banumurthy, Gokulakrishna; VanDongen, Antonius M J

    2015-03-04

    The ability to process complex spatiotemporal information is a fundamental process underlying the behavior of all higher organisms. However, how the brain processes information in the temporal domain remains incompletely understood. We have explored the spatiotemporal information-processing capability of networks formed from dissociated rat E18 cortical neurons growing in culture. By combining optogenetics with microelectrode array recording, we show that these randomly organized cortical microcircuits are able to process complex spatiotemporal information, allowing the identification of a large number of temporal sequences and classification of musical styles. These experiments uncovered spatiotemporal memory processes lasting several seconds. Neural network simulations indicated that both short-term synaptic plasticity and recurrent connections are required for the emergence of this capability. Interestingly, NMDA receptor function is not a requisite for these short-term spatiotemporal memory processes. Indeed, blocking the NMDA receptor with the antagonist APV significantly improved the temporal processing ability of the networks, by reducing spontaneously occurring network bursts. These highly synchronized events have disastrous effects on spatiotemporal information processing, by transiently erasing short-term memory. These results show that the ability to process and integrate complex spatiotemporal information is an intrinsic property of generic cortical networks that does not require specifically designed circuits. Copyright © 2015 the authors 0270-6474/15/354040-12$15.00/0.

  4. Intrinsic wave properties of Saturn Kilometric Radiation and evolution with propagation

    Science.gov (United States)

    Lamy, L.; Cecconi, B.; Zarka, P. M.; Cassini/Rpws, Mag; Caps Teams

    2010-12-01

    Investigating the crossing of the southern source region of Saturn Kilometric Radiation (SKR) by the Cassini spacecraft in late 2008, we review the intrinsic properties of SKR waves and their evolution with propagation through the kronian high-latitude plasma. In particular, we identify SKR magneto-ionic modes and estimate the electron/wave energy conversion efficiency thanks to in situ and remote observations. Then, we focus on the unusual locus of radio sources, illustrating an enhanced auroral activity. The beaming pattern is derived from different techniques for local and distant radio sources, and shows that kilometric waves are generally emitted at large angles with respect to the local magnetic field vector. Finally, we show that the SKR polarization is elliptical at the source, but becomes gradually circular along the ray path. The SKR polarization transfer is satisfactorily described in the frame of wave propagation in a cold plasma and conditions of weak mode coupling. SKR characteristics are analyzed comparatively to other equivalent auroral planetary radio emissions.

  5. Coherent Instabilities of ILC Damping Ring

    Energy Technology Data Exchange (ETDEWEB)

    Heifets, S.; Stupakov, G.; Bane, K.; /SLAC

    2006-09-27

    The paper presents the first attempt to estimates the ILC damping ring impedance and compare thresholds of the classical instabilities for several designs initially proposed for the DR. The work was carried out in the spring of 2006. Since then the choice of the DR is narrowed. Nevertheless, the analysis described may be useful for the next iterations of the beam stability. Overall, the conventional instabilities will have little impact on the ring performance provided the careful design of the ring minimizes the impedance below acceptable level indicated above. The only exception is the transverse CB instability. The longitudinal CB is less demanding. However, even the transverse CB instability would have threshold current above nominal provided the aperture in the wigglers is increased from 8 mm to 16 mm. The microwave instability needs more studies. Nevertheless, we should remember that the ILC DR is different from existing high-current machines at least in two respects: absence of the beam-beam tune spread stabilizing beams in colliders, and unusual strict requirements for low emittance. That may cause new problems such as bunch emittance dilution due to high-frequency wakes (BPMs, grooves), etc. Even if such a possibility exists, it probably universal for all machines and ought be addressed in the design of vacuum components rather than have effect on the choice of the machine design.

  6. Spin Tracking at the ILC Positron Source

    CERN Document Server

    Hartin, A; Staufenbiel, F

    2012-01-01

    In order to achieve the physics goals of future Linear Colliders, it is important that electron and positron beams are polarized. The baseline design at the International Linear Collider (ILC) foresees an e+ source based on helical undulator. Such a source provides high luminosity and polarizations. The positron source planned for ILC is based on a helical undulator system and can deliver a positron polarization of 60%. To ensure that no significant polarization is lost during the transport of the e- and e+ beams from the source to the interaction region, precise spin tracking has to be included in all transport elements which can contribute to a loss of polarization, i.e. the initial accelerating structures, the damping rings, the spin rotators, the main linac and the beam delivery system. In particular, the dynamics of the polarized positron beam is required to be investigated. In the talk recent results of positron spin tracking simulation at the source are presented. The positron yield and polarization ar...

  7. Are ILC2s Jekyll and Hyde in airway inflammation?

    Science.gov (United States)

    Ealey, Kafi N; Moro, Kazuyo; Koyasu, Shigeo

    2017-07-01

    Asthma is a complex heterogeneous disease of the airways characterized by lung inflammation, airway hyperreactivity (AHR), mucus overproduction, and remodeling of the airways. Group 2 innate lymphoid cells (ILC2s) play a crucial role in the initiation and propagation of type 2 inflammatory programs in allergic asthma models, independent of adaptive immunity. In response to allergen, helminths or viral infection, damaged airway epithelial cells secrete IL-33, IL-25, and thymic stromal lymphopoietin (TSLP), which activate ILC2s to produce type 2 cytokines such as IL-5, IL-13, and IL-9. Furthermore, ILC2s coordinate a network of cellular responses and interact with numerous cell types to propagate the inflammatory response and repair lung damage. ILC2s display functional plasticity in distinct asthma phenotypes, enabling them to respond to very different immune microenvironments. Thus, in the context of non-allergic asthma, triggered by exposure to environmental factors, ILC2s transdifferentiate to ILC1-like cells and activate type 1 inflammatory programs in the lung. In this review, we summarize accumulating evidence on the heterogeneity, plasticity, regulatory mechanisms, and pleiotropic roles of ILC2s in allergic inflammation as well as mechanisms for their suppression in the airways. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  8. Chronic homocysteine exposure causes changes in the intrinsic electrophysiological properties of cultured hippocampal neurons.

    Science.gov (United States)

    Schaub, Christina; Uebachs, Mischa; Beck, Heinz; Linnebank, Michael

    2013-04-01

    Homocystinuria is an inborn error of metabolism characterized by plasma homocysteine levels up to 500 μM, premature vascular events and mental retardation. Mild elevations of homocysteine plasma levels up to 25 μM, which are common in the general population, are associated with vascular disease, cognitive impairment and neurodegeneration. Several mechanisms of homocysteine neurotoxicity have been investigated. However, information on putative effects of hyperhomocysteinemia on the electrophysiology of neurons is limited. To screen for such effects, we examined primary cultures of mouse hippocampal neurons with the whole-cell patch-clamp technique. Homocysteine was applied intracellularly (100 μM), or cell cultures were incubated with 100 μM homocysteine for 24 h. Membrane voltage was measured in current-clamp mode, and action potential firing was induced with short and prolonged current injections. Single action potentials induced by short current injections (5 ms) were not altered by acute application or incubation of homocysteine. When we elicited trains of action potentials with prolonged current injections (200 ms), a broadening of action potentials during repetitive firing was observed in control neurons. This spike broadening was unaltered by acute application of homocysteine. However, it was significantly diminished when incubation with homocysteine was extended to 24 h prior to recording. Furthermore, the number of action potentials elicited by low current injections was reduced after long-term incubation with homocysteine, but not by the acute application. After 24 h of homocysteine incubation, the input resistance was reduced which might have contributed to the observed alterations in membrane excitability. We conclude that homocysteine exposure causes changes in the intrinsic electrophysiological properties of cultured hippocampal neurons as a mechanism of neurological symptoms of hyperhomocysteinemia.

  9. Intrinsic mutagenic properties of 5-chlorocytosine: A mechanistic connection between chronic inflammation and cancer.

    Science.gov (United States)

    Fedeles, Bogdan I; Freudenthal, Bret D; Yau, Emily; Singh, Vipender; Chang, Shiou-chi; Li, Deyu; Delaney, James C; Wilson, Samuel H; Essigmann, John M

    2015-08-18

    During chronic inflammation, neutrophil-secreted hypochlorous acid can damage nearby cells inducing the genomic accumulation of 5-chlorocytosine (5ClC), a known inflammation biomarker. Although 5ClC has been shown to promote epigenetic changes, it has been unknown heretofore if 5ClC directly perpetrates a mutagenic outcome within the cell. The present work shows that 5ClC is intrinsically mutagenic, both in vitro and, at a level of a single molecule per cell, in vivo. Using biochemical and genetic approaches, we have quantified the mutagenic and toxic properties of 5ClC, showing that this lesion caused C→T transitions at frequencies ranging from 3-9% depending on the polymerase traversing the lesion. X-ray crystallographic studies provided a molecular basis for the mutagenicity of 5ClC; a snapshot of human polymerase β replicating across a primed 5ClC-containing template uncovered 5ClC engaged in a nascent base pair with an incoming dATP analog. Accommodation of the chlorine substituent in the template major groove enabled a unique interaction between 5ClC and the incoming dATP, which would facilitate mutagenic lesion bypass. The type of mutation induced by 5ClC, the C→T transition, has been previously shown to occur in substantial amounts both in tissues under inflammatory stress and in the genomes of many inflammation-associated cancers. In fact, many sequence-specific mutational signatures uncovered in sequenced cancer genomes feature C→T mutations. Therefore, the mutagenic ability of 5ClC documented in the present study may constitute a direct functional link between chronic inflammation and the genetic changes that enable and promote malignant transformation.

  10. When Insult Is Added to Injury: Cross Talk between ILCs and Intestinal Epithelium in IBD

    Directory of Open Access Journals (Sweden)

    Esmé van der Gracht

    2016-01-01

    Full Text Available Inflammatory bowel disease (IBD is characterized by an impairment of the integrity of the mucosal epithelial barrier, which causes exacerbated inflammation of the intestine. The intestinal barrier is formed by different specialized epithelial cells, which separate the intestinal lumen from the lamina propria. In addition to its crucial role in protecting the body from invading pathogens, the intestinal epithelium contributes to intestinal homeostasis by its biochemical properties and communication to underlying immune cells. Innate lymphoid cells (ILCs are a recently described population of lymphocytes that have been implicated in both mucosal homeostasis and inflammation. Recent findings indicate a critical feedback loop in which damaged epithelium activates these innate immune cells to restore epithelial barrier function. This review will focus on the signalling pathways between damaged epithelium and ILCs involved in repair of the epithelial barrier and tissue homeostasis and the relationship of these processes with the control of IBD.

  11. When Insult Is Added to Injury: Cross Talk between ILCs and Intestinal Epithelium in IBD.

    Science.gov (United States)

    van der Gracht, Esmé; Zahner, Sonja; Kronenberg, Mitchell

    2016-01-01

    Inflammatory bowel disease (IBD) is characterized by an impairment of the integrity of the mucosal epithelial barrier, which causes exacerbated inflammation of the intestine. The intestinal barrier is formed by different specialized epithelial cells, which separate the intestinal lumen from the lamina propria. In addition to its crucial role in protecting the body from invading pathogens, the intestinal epithelium contributes to intestinal homeostasis by its biochemical properties and communication to underlying immune cells. Innate lymphoid cells (ILCs) are a recently described population of lymphocytes that have been implicated in both mucosal homeostasis and inflammation. Recent findings indicate a critical feedback loop in which damaged epithelium activates these innate immune cells to restore epithelial barrier function. This review will focus on the signalling pathways between damaged epithelium and ILCs involved in repair of the epithelial barrier and tissue homeostasis and the relationship of these processes with the control of IBD.

  12. ILC Beam delivery WG summary: Optics, collimation and background

    Energy Technology Data Exchange (ETDEWEB)

    Angal-Kalinin, D.; Jackson, F.; /Daresbury; Mokhov, N.V.; /Fermilab; Kuroda, S.; /KEK, Tsukuba; Seryi, A.A.; /SLAC

    2006-07-01

    The paper summarizes the work of the Beam Delivery working group (WG4) at Snowmass 2005 workshop, focusing on status of optics, layout, collimation and detector background. The strawman layout with two interaction regions was recommended at the first ILC workshop at KEK in November 2004. Two crossing-angle designs were included in this layout. The design of the ILC BDS has evolved since the first ILC workshop. The progress on the BDS design including the collimation system, and extraction line design have been reviewed and the design issues were discussed during the WG4 sessions at the Snowmass, and are described in this paper.

  13. ILC Reference Design Report Volume 1 - Executive Summary

    CERN Document Server

    Brau, James; Walker, Nicholas; Dabrowski, Wladyslaw; Gajewski, Jan; Idzik, Marek; Kisielewska, Danuta; Kulis, Szymon; Suszycki, Leszek; Swientek, Krzysztof; Martyn, Hans-Ulrich; Bernreuther, Werner; Feld, Lutz; Hebbeker, Thomas; Muennich, Astrid; Roth, Stefan; Stahl, Achim; Tonutti, Manfred; Rindani, Saurabh; Sarkar, Utpal; Singh, S.K.; Adloff, Catherine; Delebecque, Pierre; Hermel, Richard; Karyotakis, Yannis; Lafaye, Remi; Prast, Julie; Muhlleitner, Milada Margarete; Singh, R.K.; Wagner, Carlos E.M.; Antipov, Sergei; Arnold, Ned; Berger, Edmond; Carwardine, John; Drake, Gary; Emery, Louis; Friedsam, Horst; Fuerst, Joel; Gai, Wei; Gerbick, Scot; Gerig, Rod; Kelly, Michael; Kim, Kwang-Je; Lenkszus, Frank; Liu, Wanming; Magill, Stephen; Noonan, John; Repond, Jose; Saunders, Claude; Shepard, Ken; Underwood, David G.; Wang, Haitao; Weerts, Harry; Xia, Lei; Xiao, Aimin; Zhang, Jinlong; Yock, Philip; Singh, Bhartendu K.; Ananthanarayan, B.; Biswal, S.S.; Godbole, Rohini; Vempati, Sundir K.; Comerma, Albert; Dieguez, Angel; Garrido, Luis; Gascon, David; Graciani, Ricardo; Grauges, Eugeni; Herms, Atila; Balbuena, Juan Pablo; Cabruja, Enric; Lozano, Manuel; Pellegrini, Giulio; Miquel, Ramon; Lux, Thorsten; Martinez, Manel; Padilla, Cristobal; Riu, Imma; Ward, Bennie; Sun, Yipeng; Ablikim, Medina; Bai, Sha; Bi, Xiao-Jun; Cao, J.S.; Chen, He Sheng; Chen, Sen Yu; Chen, Yuan Bo; Cheng, Jian; Chi, Yun Long; Dai, Jian Ping; Dong, Dong; Dong, Hai Yi; Du, Shuxian; Fang, Shou Xian; Gao, Jian She; Gao, Jie; Ge, Ming Qi; Ge, Rui; Geng, Zhe Qiao; Gu, Jun; He, An; Hou, Mi; Hu, Tao; Huang, Tong Ming; Jiang, Xiao Ming; Jin, Shan; Kang, Wen; Kong, Xiang Cheng; Li, Chun Hua; Li, Da Zhang; Li, Gang; Li, Shao Peng; Li, Weiguo; Li, Xiao Ping; Li, Zhong Quan; Liu, Shao Zhen; Liu, Wei Bin; Liu, Ya Ping; Liu, Yu Dong; Lu, Cai-Dian; Ma, Li; Ma, Qiang; Ouyang, Qun; Pam, Wei Min; Pei, Guo Xi; Pei, Shi Lun; Peng, G.X.; Qin, Qing; Qu, Hua Min; Shi, Cai Tu; Sun, Hong; Sun, Yi; Wang, Chun Hong; Wang, Dou; Wang, Guang Wei; Wang, Jiang; Wang, Jiu Qing; Wang, Shu Hong; Wang, Yi Fang; Wang, Zheng; Xie, Jia Lin; Xing, Zhi-Zhong; Xu, Gang; Xu, Qing Jin; Yu, Cheng Hui; Yu, Xian Ming; Yuan, Chang-Zheng; Yue, Jun Hui; Zhai, Ji Yuan; Zhang, Chuang; Zhang, He; Zhang, Jiawen; Zhang, Jing Ru; Zhang, Jing; Zhang, X.; Zhang, Yuan; Zhao, Ji Jiu; Zhao, Jing Xia; Zhao, Sheng Chu; Zhou, De Min; Zhou, Shun; Zhu, Xiong Wei; Zong, Zhang Guo; Liu, Chun; Wu, Yue Liang; Yang, Jin Min; Liang, Jian Tao; Liu, Li Qiang; Lu, Wen Hui; Xiong, Lian You; Zhang, Liang; Zhao, Tong Xian; Afanaciev, Konstantin; Ignatenko, Alexandr; Shumeiko, Nikolai; Manghisoni, Massimo; Re, Valerio; Traversi, Gianluca; Eigen, Gerald; Osland, Per; Handu, Virender K.; Jawale, Suresh B.; Joshi, Gopal; Pande, Manjiri; Pande, Rajni; Rao, Sista V.L.S.; Singh, Pitamber; Sinha, Anil K.; Suthar, Rameshwar L.; Topkar, Anita; Adey, David; Hawkes, Chris; Hillier, Stephen James; Mikami, Yoshinari; Miller, Owen; Stockton, Mark; Watson, Nigel Keith; Wilson, John A.; Petersen, Troels Christian; Driouichi, Chafik; Hansen, Jorgen Beck; Hansen, Jorn Dines; Klinkby, Esben; Xella, Stefania; Von Toerne, Eckhard; Brock, Ian; Desch, Klaus; Dreiner, Herbert; Hohlfeld, Mark; Killenberg, Martin; Kittel, Olaf; Koch, Manuel; Kohrs, Robert; Krautscheid, Thorsten; Kruger, Hans; Langenfeld, Ulrich; Pleier, Marc-Andre; Reuen, Lars; Ummenhofer, Martin; Wermes, Norbert; Wienemann, Peter; Butler, John; Cussans, David; Goldstein, Joel; Grimes, Mark; Heath, Helen; Lynch, Clare; Velthuis, Jaap J.; Hearty, Christopher; Mattison, Thomas; Anerella, Michael; Dawson, Sally; Marone, Andrew; Morse, William Michael; Parker, Brett; Parsa, Zohreh; Pogorelsky, Igor; Radeka, Veljko; Yakimenko, Vitaly; Partridge, Richard; Narain, Meenakshi; Coca, Cornelia; Orlandea, Marius Ciprian; Popescu, Sorina; Teodorescu, Eliza; Hajdu, Csaba; Horvath, Dezso; Grojean, Christophe; Baddams, Nigel; Baldy, Jean-Luc; Camporesi, Tiziano; Capatina, Ofelia; De Roeck, Albert; Delahaye, Jean-Pierre; Eliasson, Peder; Ellis, John R.; Ferguson, John; Gastal, Martin; Hauschild, Michael; Hauviller, Claude; Hawkings, Richard; Kraml, Sabine; Latina, Andrea; Parma, Vittorio; Pedersen, John; Quesnel, Jean-Pierre; Rinolfi, Louis; Rolandi, Gigi; Ruehl, Ingo; Sauli, Fabio; Schulte, Daniel; Tavian, Laurent; Zimmermann, Frank; Chung, Jin-Hyuk; Hwang, Youngseok; Kim, Donghee; Kim, Eun San; Kim, Guinyun; Kim, Hongjoo; Kim, Hyoungsuk; Kim, Kyung Sook; Kim, Youngim; Park, Hwanbae; Shin, Seunghwan; Son, Dongchul; Suh, Jun Suhk; Bhattacherjee, Biplob; Datta, Anindya; Ghosh, Kirtiman; Kundu, Anirban; Bhandari, R.K.; Chattopadhyay, Subhasis; Mallik, C.; Nabhiraj, P.Y.

    2007-01-01

    The International Linear Collider (ILC) is a 200-500 GeV center-of-mass high-luminosity linear electron-positron collider, based on 1.3 GHz superconducting radio-frequency (SCRF) accelerating cavities. The ILC has a total footprint of about 31 km and is designed for a peak luminosity of 2x10^34 cm^-2s^-1. This report is the Executive Summary (Volume I) of the four volume Reference Design Report. It gives an overview of the physics at the ILC, the accelerator design and value estimate, the detector concepts, and the next steps towards project realization.

  14. The Olivo-cerebellar System: A Key to understanding the functional significance of intrinsic oscillatory brain properties

    Directory of Open Access Journals (Sweden)

    Rodolfo R Llinas

    2014-01-01

    Full Text Available The reflexological view of brain function (Sherrington 1906 has played a crucial role in defining both the nature of connectivity and the role of the synaptic interactions among neuronal circuits. One implicit assumption of this view, however, has been that CNS function is fundamentally driven by sensory input. This view was questioned as early as the beginning of the last century when a possible role for intrinsic activity in CNS function was proposed by Thomas Graham Brow (Brown 1911; Brown 1914. However, little progress was made in addressing intrinsic neuronal properties in vertebrates until the discovery of calcium conductances in vertebrate central neurons leading dendritic electroresponsiveness (Llinas and Hess 1976, Llinas and Sugimori 1980a and b and subthreshold neuronal oscillation in mammalian inferior olive (IO neurons (Llinas and Yarom 1981; Llinas and Yarom 1981.This happened in parallel with a similar set of findings concerning invertebrate neuronal system (Marder and Bucher 2001. The generalization into a more global view of intrinsic rhythmicity, at forebrain level, occurred initially with the demonstration that the thalamus has similar oscillatory properties (Llinas and Jahnsen 1982 and the ionic properties responsible for some oscillatory activity were, in fact, similar to those in the IO (Jahnsen and Llinas 1984; Llinas 1988. Thus lending support to the view that not only motricity, but cognitive properties, are organized as coherent oscillatory states (Pare, deCurtis et al. 1992; Singer 1993; Hardcastle 1997; Llinas, Ribary et al. 1998; Varela, Lachaux et al. 2001.

  15. ILC RF System R and D

    Energy Technology Data Exchange (ETDEWEB)

    Adolphsen, Chris; /SLAC

    2012-07-03

    The Linac Group at SLAC is actively pursuing a broad range of R&D to improve the reliability and reduce the cost of the L-band (1.3 GHz) rf system proposed for the ILC linacs. Current activities include the long-term evaluation of a 120 kV Marx Modulator driving a 10 MW Multi-Beam Klystron, design of a second-generation Marx Modulator, testing of a sheet-beam gun and beam transport system for a klystron, construction of an rf distribution system with remotely-adjustable power tapoffs, and development of a system to combine the power from many klystrons in low-loss circular waveguide where it would be tapped-off periodically to power groups of cavities. This paper surveys progress during the past few years.

  16. ILC Linac R&D at SLAC

    Energy Technology Data Exchange (ETDEWEB)

    Adolphsen, C.; /SLAC

    2006-08-09

    Since the ITRP recommendation in August 2004 to use superconducting rf technology for a next generation linear collider, the former NLC Group at SLAC has been actively pursuing a broad range of R&D for this collider (the ILC). In this paper, the programs concerning linac technology are reviewed. Current activities include the development of a Marx-style modulator and a 10 MW sheet-beam klystron, operation of an L-band (1.3 GHz) rf source using an SNS HVCM modulator and commercial klystrons, design of a more efficient and less costly rf distribution system, construction of a coupler component test stand, fabrication of a prototype positron capture cavity, beam tests of prototype S-band linac beam position monitors and preparations for magnetic center stability measurements of a prototype SC linac quad.

  17. The Photoelectric Properties of Intrinsic Oxide - p-In4Se3 Heterojunctions

    Directory of Open Access Journals (Sweden)

    V.N. Katerynchuk

    2016-10-01

    Full Text Available The intrinsic oxide - p-In4Se3 heterojunction was fabricated by the method of thermal oxidation of semiconductor substrate for the first time. The qualitative energy band diagram was built on the basis of analysis of electrical and photovoltaic characteristics of the heterojunction. The character of dominating current transport mechanisms through the barrier is determined by thermionic emission, rather than carrier diffusion. The AFM-images of oxide layer surface and the photosensitivity spectrum of intrinsic oxide  p-In4Se3 heterojunctions also were presented.

  18. Neutralino Relic Density in the CPVMSSM at the ILC

    CERN Document Server

    Bélanger, G; Kraml, S; Martyn, H U; Pukhov, A

    2009-01-01

    We discuss ILC measurements for a specific MSSM scenario with CP phases, where the lightest neutralino, a candidate for dark matter, annihilates through t-channel exchange of light staus. These prospective ILC measurements are used to fit the underlying model parameters. A collider prediction of the relic density of the neutralino from this fit gives 0.116

  19. Non-simplified SUSY. {tau}-coannihilation at LHC and ILC

    Energy Technology Data Exchange (ETDEWEB)

    Berggren, M.; Cakir, A.; Krueger, D.; List, J.; Lobanov, A.; Melzer-Pellmann, I.A.

    2013-07-15

    Simplified models have become a widely used and important tool to cover the more diverse phenomenology beyond constrained SUSY models. However, they come with a substantial number of caveats themselves, and great care needs to be taken when drawing conclusions from limits based on the simplified approach. To illustrate this issue with a concrete example, we examine the applicability of simplified model results to a series of full SUSY model points which all feature a small {tau} -LSP mass difference, and are compatible with electroweak and flavor precision observables as well as current LHC results. Various channels have been studied using the Snowmass Combined LHC detector implementation in the Delphes simulation package, as well as the Letter of Intent or Technical Design Report simulations of the ILD detector concept at the ILC. We investigated both the LHC and ILC capabilities for discovery, separation and identification of all parts of the spectrum. While parts of the spectrum would be discovered at the LHC, there is substantial room for further discoveries and property determination at the ILC.

  20. Dedifferentiation of intrinsic response properties of motoneurons in organotypic cultures of the spinal cord of the adult turtle

    DEFF Research Database (Denmark)

    Perrier, J F; Noraberg, J; Simon, M;

    2000-01-01

    Explant cultures from the spinal cord of adult turtles were established and used to study the sensitivity of the intrinsic response properties of motoneurons to the changes in connectivity and milieu imposed by isolation in culture. Transverse sections 700 microm thick were explanted on cover slips...... the ability to fire repetitively. By the second week in culture, a fraction of motoneurons displayed fast and slow transient outward rectification and low-threshold calcium spikes, features not seen in turtle motoneurons in acute slices. On the other hand, properties mediated by L-type Ca2+ channels...

  1. Layer-by-layer and intrinsic analysis of molecular and thermodynamic properties across soft interfaces

    Energy Technology Data Exchange (ETDEWEB)

    Sega, Marcello [Computational Physics Group, University of Vienna, Sensengasse 8/9, 1090 Vienna (Austria); Fábián, Balázs [Institut UTINAM (CNRS UMR 6213), Université de Franche-Comté, 16 route de Gray, F-25030 Besançon (France); Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Szt. Gellért tér 4, H-1111 Budapest (Hungary); Jedlovszky, Pál [Laboratory of Interfaces and Nanosize Systems, Institute of Chemistry, Eötvös Loránd University, Pázmány P. Stny 1/A, H-1117 Budapest (Hungary); MTA-BME Research Group of Technical Analytical Chemistry, Szt. Gellért tér 4, H-1111 Budapest (Hungary); Department of Chemistry, EKF, Leányka u. 6, H-3300 Eger (Hungary)

    2015-09-21

    Interfaces are ubiquitous objects, whose thermodynamic behavior we only recently started to understand at the microscopic detail. Here, we borrow concepts from the techniques of surface identification and intrinsic analysis, to provide a complementary point of view on the density, stress, energy, and free energy distribution across liquid (“soft”) interfaces by analyzing the respective contributions coming from successive layers.

  2. Group 3 innate lymphoid cells (ILC3s): Origin, differentiation, and plasticity in humans and mice.

    Science.gov (United States)

    Montaldo, Elisa; Juelke, Kerstin; Romagnani, Chiara

    2015-08-01

    Since their discovery, innate lymphoid cells (ILCs) have been the subject of intense research. As their name implies, ILCs are innate cells of lymphoid origin, and can be grouped into subsets based on their cytotoxic activity, cytokine profile, and the transcriptional requirements during ILC differentiation. The main ILC groups are "killer" ILCs, comprising NK cells, and "helper-like" ILCs (including ILC1s, ILC2s, and ILC3s). This review examines the origin, differentiation stages, and plasticity of murine and human ILC3s. ILC3s express the retinoic acid receptor (RAR) related orphan receptor RORγt and the signature cytokines IL-22 and IL-17. Fetal ILC3s or lymphoid tissue inducer cells are required for lymphoid organogenesis, while postnatally developing ILC3s are important for the generation of intestinal cryptopatches and isolated lymphoid follicles as well as for the defence against pathogens and epithelial homeostasis. Here, we discuss the transcription factors and exogenous signals (including cytokines, nutrients and cell-to-cell interaction) that drive ILC3 lineage commitment and acquisition of their distinctive effector program.

  3. Construction and commissioning of a hadronic test-beam calorimeter to validate the particle-flow concept at the ILC

    Energy Technology Data Exchange (ETDEWEB)

    Groll, M.

    2007-06-15

    electronics, which has to be suitable for the SiPM signal. Understanding the characteristics of the electronic chain and its interplay with the SiPM has been a central part of the commissioning e ort. First working experience with complete readout layers have been gained at DESY. The calibration procedure of the system has been studied by using well understood electromagnetic shower processes. Afterwards, the readout layers in combination with the steel absorber structure has been exposed to a hadronic test beam at the CERN facility. The ne segmentation of this calorimeter prototype gives for the rst time the possibility to access intrinsic properties of hadronic showers. These properties can be used later to compare and validate various existing hadronic shower simulations to achieve a better understanding of the underlying processes of hadronic interactions in matter. (orig.)

  4. Intrinsic carrier transport properties of solution-processed organic–inorganic perovskite films

    Science.gov (United States)

    Matsushima, Toshinori; Hwang, Sunbin; Terakawa, Shinobu; Fujihara, Takashi; Sandanayaka, Atula S. D.; Qin, Chuanjiang; Adachi, Chihaya

    2017-02-01

    The true performance of field-effect transistors with spin-coated organic–inorganic perovskite (C6H5C2H4NH3)2SnI4 semiconductor layers remains unknown because of the presence of contact resistance (R C). To evaluate the intrinsic carrier mobility (μ), we fabricated perovskite transistors with large channel lengths (L). The field-effect μ gradually increased with increasing L and then became constant in the large-L region, because of the reduced contribution of R C relative to the total resistance. The intrinsic μ values estimated from this region reached 26 and 4.8 cm2 V‑1 s‑1 for holes and electrons, respectively, which are the highest ever reported in any perovskite transistor.

  5. Short-range correlations in carbon-12, oxygen-16, and neon-20: Intrinsic properties

    Science.gov (United States)

    Braley, R. C.; Ford, W. F.; Becker, R. L.; Patterson, M. R.

    1972-01-01

    The Brueckner-Hartree-Fock (BHF) method has been applied to nuclei whose intrinsic structure is nonspherical. Reaction matrix elements were calculated as functions of starting energy for the Hamada-Johnston interaction using the Pauli operator appropriate to O-16 and a shifted oscillator spectrum for virtual excited states. Binding energies, single particle energies, radii, and shape deformations of the intrinsic state, in ordinary as well as renormalized BHF, are discussed and compared with previous HF studies and with experiment when possible. Results are presented for C-12, 0-16 and Ne-20. It is found that the binding energies and radii are too small, but that separation energies are well reproduced when the renormalized theory is used.

  6. Structure of Gamma-Ray Burst jets: intrinsic versus apparent properties

    CERN Document Server

    Salafia, O S; Pescalli, A; Ghirlanda, G; Nappo, F

    2015-01-01

    With this paper we introduce the concept of apparent structure of a GRB jet, as opposed to its intrinsic structure. The latter is customarily defined specifying the functions epsilon(theta) (the energy emitted per jet unit solid angle) and Gamma(theta) (the Lorentz factor of the emitting material); the apparent structure is instead defined by us as the isotropic equivalent energy E_iso(theta_v) as a function of the viewing angle theta_v. We show how to predict the apparent structure of a jet given its intrinsic structure. We find that a Gaussian intrinsic structure yields a power law apparent structure: this opens a new viewpoint on the Gaussian (which can be understood as a proxy for a realistic narrow, well collimated jet structure) as a possible candidate for a quasi-universal GRB jet structure. We show that such a model (a) is consistent with recent constraints on the observed luminosity function of GRBs; (b) implies fewer orphan afterglows with respect to the standard uniform model; (c) can break out the...

  7. Intrinsic Motivation Inventory: Psychometric Properties in the Context of First Language and Mathematics Learning

    Directory of Open Access Journals (Sweden)

    Vera Monteiro

    2015-09-01

    Full Text Available Intrinsic Motivation Inventory (IMI is a multidimensional measurement grounded on the Self-Determination Theory (SDT used in assessing the subjective experiences of participants when developing an activity. The aim of this study is to analyze the characteristics of IMI among Portuguese students, testing four organizational models (unidimensional, multidimensional, hierarchical and bi-factor. A total of 3685 students from the 5th to the 12th grades (50.4% boys participated in the study (M = 13.67, SD = 2.26. Two versions of IMI were used (First Language and Mathematics with twenty-one items distributed over five subscales: Enjoyment, Perceived Competence, Pressure/Tension, Perceived Choice and Value/Utility. The confirmatory factor analysis corroborated the multidimensionality of intrinsic motivation, and that the bi-factor model presented the best fit indexes. This model showed the existence of one general factor, resulting from the contribution of all individual dimensions and the particularities of most of them. Furthermore, results also highlighted satisfactory reliability scores both through Cronbach's alpha scores and Composite reliability scores. These results indicate that this scale is appropriate to evaluate the underlying constructs of the theoretical model of SDT and allows for the calculation of a global measure of intrinsic motivation, as well as specific measures for their predictors.

  8. Site-specific doping, tunable dielectric properties and intrinsic paramagnetism in Mn-doped SrTiO3

    Indian Academy of Sciences (India)

    D Choudhury

    2015-06-01

    Mn doping in SrTiO3 leads to the emergence of qualitatively distinct and novel physical properties. We show that Mn ions can be controllably doped at either of the perovskite (Sr) or (Ti) site as well as at both sites simultaneously and the resultant physical properties depend intimately on the particular dopant site. We critically review the recent literature on various Mn-doped SrTiO3 systems, which includes reports of dielectric glass, spin-glass and ferromagnetism and by combining experiments with first-principles calculations, we demonstrate that depending on the particular dopant site for Mn ions, the dielectric properties can be widely tuned from a quantum paraelectric to a dielectric glass. However, the intrinsic magnetism in all these cases remains essentially paramagnetic for phase-pure systems.

  9. Intraoperative optical biopsy for brain tumors using spectro-lifetime properties of intrinsic fluorophores

    Science.gov (United States)

    Vasefi, Fartash; Kittle, David S.; Nie, Zhaojun; Falcone, Christina; Patil, Chirag G.; Chu, Ray M.; Mamelak, Adam N.; Black, Keith L.; Butte, Pramod V.

    2016-04-01

    We have developed and tested a system for real-time intra-operative optical identification and classification of brain tissues using time-resolved fluorescence spectroscopy (TRFS). A supervised learning algorithm using linear discriminant analysis (LDA) employing selected intrinsic fluorescence decay temporal points in 6 spectral bands was employed to maximize statistical significance difference between training groups. The linear discriminant analysis on in vivo human tissues obtained by TRFS measurements (N = 35) were validated by histopathologic analysis and neuronavigation correlation to pre-operative MRI images. These results demonstrate that TRFS can differentiate between normal cortex, white matter and glioma.

  10. Synthesis and gas transport properties of hydroxyl-functionalized polyimides with intrinsic microporosity

    KAUST Repository

    Ma, Xiaohua

    2012-05-08

    A newly designed diamine monomer, 3,3,3′,3′-tetramethyl-1, 1′-spirobisindane-5,5′-diamino-6,6′-diol, was successfully used to synthesize two types of polyimides for membrane-based gas separation applications. The novel polymers integrate significant microporosity and polar hydroxyl groups, showing the combined features of polymers of intrinsic microporosity (PIMs) and functional polyimides (PIs). They possess high thermal stability, good solubility, and easy processability for membrane fabrication; the resulting membranes exhibit good permeability owing to the intrinsic microporosity introduced by the highly contorted PIM segments as well as high CO 2/CH 4 selectivity that arises from the hydroxyl groups. The membranes show CO 2/CH 4 selectivities of >20 when tested with a 1:1 CO 2/CH 4 mixture for feed pressures up to 50 bar. In addition, the incorporation of hydroxyl groups and microporosity in the polymers enhances their affinity to water, leading to remarkable water sorption capacities of up to 22 wt % at 35 °C and 95% relative humidity. © 2012 American Chemical Society.

  11. Insights into the sonochemical synthesis and properties of salt-free intrinsic plutonium colloids

    Science.gov (United States)

    Dalodière, Elodie; Virot, Matthieu; Morosini, Vincent; Chave, Tony; Dumas, Thomas; Hennig, Christoph; Wiss, Thierry; Dieste Blanco, Oliver; Shuh, David K.; Tyliszcak, Tolek; Venault, Laurent; Moisy, Philippe; Nikitenko, Sergey I.

    2017-03-01

    Fundamental knowledge on intrinsic plutonium colloids is important for the prediction of plutonium behaviour in the geosphere and in engineered systems. The first synthetic route to obtain salt-free intrinsic plutonium colloids by ultrasonic treatment of PuO2 suspensions in pure water is reported. Kinetics showed that both chemical and mechanical effects of ultrasound contribute to the mechanism of Pu colloid formation. In the first stage, fragmentation of initial PuO2 particles provides larger surface contact between cavitation bubbles and solids. Furthermore, hydrogen formed during sonochemical water splitting enables reduction of Pu(IV) to more soluble Pu(III), which then re-oxidizes yielding Pu(IV) colloid. A comparative study of nanostructured PuO2 and Pu colloids produced by sonochemical and hydrolytic methods, has been conducted using HRTEM, Pu LIII-edge XAS, and O K-edge NEXAFS/STXM. Characterization of Pu colloids revealed a correlation between the number of Pu-O and Pu-Pu contacts and the atomic surface-to-volume ratio of the PuO2 nanoparticles. NEXAFS indicated that oxygen state in hydrolytic Pu colloid is influenced by hydrolysed Pu(IV) species to a greater extent than in sonochemical PuO2 nanoparticles. In general, hydrolytic and sonochemical Pu colloids can be described as core-shell nanoparticles composed of quasi-stoichiometric PuO2 cores and hydrolyzed Pu(IV) moieties at the surface shell.

  12. Common ground in ILC and CLIC detector concepts

    CERN Multimedia

    Daisy Yuhas

    2013-01-01

    The Compact Linear Collider and the International Linear Collider will accelerate particles and create collisions in different ways. Nonetheless, the detector concepts under development share many commonalities.   Timepix chips under scrutiny in the DESY test beam with the help of the beam telescope. CERN physicist Dominik Dannheim explains that the CLIC detector plans are adaptations of the ILC detector designs with a few select modifications. “When we started several years ago, we did not want to reinvent the wheel,” says Dannheim. “The approved ILC detector concepts served as an excellent starting point for our designs.” Essential differences Both CLIC and ILC scientists foresee general-purpose detectors that make measurements with exquisite precision. These colliders, however, have very different operating parameters, which will have important consequences for the various detector components. The ILC’s collision energy is set at 500 GeV ...

  13. CLIC/ILC Researchers Explore New Avenues for Collaboration

    CERN Multimedia

    Katarina Anthony

    2010-01-01

    Researchers from CLIC and ILC met for their first common International Workshop on Linear Colliders, which was held in Geneva from 18 to 22 October. Although the talks were mostly scientific and technical, the political message behind them was a breakthrough, as the workshop showed the progress made in unifying the two communities.   The International Workshop on Linear Colliders (IWLC), which was organised by the European Committee for Future Accelerators, hosted by CERN, and held at CERN and the International Conference Centre in Geneva, attracted a large audience of about 500 experts. Although there have been other joint conferences between the CLIC and ILC communities before, they have all been focused on specific technical and/or managerial issues. The IWLC was part of an ongoing effort by CLIC and ILC to provide an environment in which researchers can exchange ideas, inform their peers about their most recent achievements and work together on common issues. Given the possible technical ov...

  14. Effects of CE substitution on the microstructures and intrinsic magnetic properties of Nd–Fe–B alloy

    Energy Technology Data Exchange (ETDEWEB)

    Li, Zhi [College of Materials Science and Engineering, Beijing University of Technology, Beijing 100124 (China); The Key Laboratory of Advanced Functional Materials, Ministry of Education, Beijing University of Technology, Beijing 100124 (China); Liu, Weiqiang, E-mail: liuweiqiang77@hotmail.com [College of Materials Science and Engineering, Beijing University of Technology, Beijing 100124 (China); The Key Laboratory of Advanced Functional Materials, Ministry of Education, Beijing University of Technology, Beijing 100124 (China); Zha, Shanshun; Li, Yuqing; Wang, Yunqiao; Zhang, Dongtao; Yue, Ming; Zhang, Jiuxing [College of Materials Science and Engineering, Beijing University of Technology, Beijing 100124 (China); The Key Laboratory of Advanced Functional Materials, Ministry of Education, Beijing University of Technology, Beijing 100124 (China); Huang, Xiulian [Anhui Province Key Laboratories of Rare Earth Permanent Magnet Materials, Anhui 231500 (China); Anhui Earth-panda Advance Magnetic Material co., Ltd., Anhui 231500 (China)

    2015-11-01

    (Nd{sub 1−x}Ce{sub x}){sub 30}Fe{sub 69}B (x=0, 0.1, 0.2, 0.3, 0.4, 0.5, and 0.6) alloys were prepared by inducting melting, and the effect of substitution of Ce for Nd on their microstructure and intrinsic magnetic properties were investigated. With the increase of Ce content, Curie temperature (T{sub c}) decreases from 582.4 to 504.8 K, saturation magnetization (M{sub s}) decreases from 15.88 to 12.71 kGs, and anisotropy field (H{sub A}) decreases from 67.4 to 52.7 kOe. However, the reductions of the intrinsic magnetic properties are relatively gentle, and they still have potential to be prepared as permanent magnets. Moreover, further microstructure observations show that Ce is tending to diffuse into the Nd-rich grain boundary phase instead of main phase during the substitute process. Such aggregation behavior is beneficial to fabricate Ce containing magnet with high M{sub s}. - Highlights: • With the increase of Ce, T{sub c}, M{sub s}, and H{sub A} decrease gradually, but relatively gentle. • The (Nd{sub 1-x}Ce{sub x}){sub 30}Fe{sub 69}B alloys have potential to be prepared as permanent magnets. • Ce is tending to diffuse into the Nd-rich phase instead of main phase.

  15. Local pulsatile contractions are an intrinsic property of the myosin 2A motor in the cortical cytoskeleton of adherent cells

    Science.gov (United States)

    Baird, Michelle A.; Billington, Neil; Wang, Aibing; Adelstein, Robert S.; Sellers, James R.; Fischer, Robert S.; Waterman, Clare M.

    2017-01-01

    The role of nonmuscle myosin 2 (NM2) pulsatile dynamics in generating contractile forces required for developmental morphogenesis has been characterized, but whether these pulsatile contractions are an intrinsic property of all actomyosin networks is not known. Here we used live-cell fluorescence imaging to show that transient, local assembly of NM2A “pulses” occurs in the cortical cytoskeleton of single adherent cells of mesenchymal, epithelial, and sarcoma origin, independent of developmental signaling cues and cell–cell or cell–ECM interactions. We show that pulses in the cortical cytoskeleton require Rho-associated kinase– or myosin light chain kinase (MLCK) activity, increases in cytosolic calcium, and NM2 ATPase activity. Surprisingly, we find that cortical cytoskeleton pulses specifically require the head domain of NM2A, as they do not occur with either NM2B or a 2B-head-2A-tail chimera. Our results thus suggest that pulsatile contractions in the cortical cytoskeleton are an intrinsic property of the NM2A motor that may mediate its role in homeostatic maintenance of tension in the cortical cytoskeleton of adherent cells. PMID:27881665

  16. CXCR6 Expression Is Important for Retention and Circulation of ILC Precursors

    Directory of Open Access Journals (Sweden)

    Sylvestre Chea

    2015-01-01

    Full Text Available Innate lymphoid cells are present at mucosal sites and represent the first immune barrier against infections, but what contributes to their circulation and homing is still unclear. Using Rag2−/−Cxcr6Gfp/+ reporter mice, we assessed the expression and role of CXCR6 in the circulation of ILC precursors and their progeny. We identify CXCR6 expressing ILC precursors in the bone marrow and characterize their significant increase in CXCR6-deficient mice at steady state, indicating their partial retention in the bone marrow after CXCR6 ablation. Circulation was also impaired during embryonic life as fetal liver from CXCR6-deficient embryos displayed decreased numbers of ILC3 precursors. When injected, fetal CXCR6-deficient ILC3 precursors also fail to home and reconstitute ILC compartments in vivo. We show that adult intestinal ILC subsets have heterogeneous expression pattern of CXCR6, integrin α4β7, CD62L, CD69, and CD44, with ILC1 and ILC3 being more likely tissue resident lymphocytes. Intestinal ILC subsets were unchanged in percentages and numbers in both mice. We demonstrate that the ILC frequency is maintained due to a significant increase of ILC peripheral proliferation, as well as an increased proliferation of the in situ ILC precursors to compensate their retention in the bone marrow.

  17. An investigation of the effect of grain size on some properties of intrinsic Josephson junction

    Energy Technology Data Exchange (ETDEWEB)

    Aslan Çataltepe, Özden, E-mail: ozdenaslan@yahoo.com [Gedik University, Faculty of Engineering, Yakacık/Kartal, 34876, İstanbul (Turkey); Güven Özdemir, Zeynep [Yıldız Technical University, Physics Department, Faculty of Science and Arts, Davutpaşa Campus, Esenler 34210, İstanbul (Turkey); Onbaşli, Ülker [University of Marmara, Physics Department, Faculty of Science and Arts, Rıdvanpaşa cad.3.sok., 85/12, 34730, Göztepe, İstanbul (Turkey)

    2013-08-15

    Highlights: ► Grain size, t, determined by SEM, has a key role for intrinsic Josephson Junctions. ► Supercurrent density and Josephson penetration depth are changed with variation of t. ► HgBa{sub 2}Ca{sub 2}Cu{sub 3}O{sub 8+x} (Hg-1223) consists of intrinsic Josephson junction array. ► The effect of t on electrodynamics parameters of Hg-1223 was investigated by SEM. -- Abstract: Some superconducting parameters of the high temperature superconductors, such as the plasma frequency and the critical transition temperature, depend on the oxygen content of the material. Since the oxygen content is effective on the grain size of the system, the under, optimally and over oxygen doped Hg-based copper oxide layered superconductors, which have the hole type superconductivity, have been investigated in this study. As is known that the concentration of hole type carriers is increased via optimally oxygen annealing. In other words, relatively higher values for the various critical parameters are achieved by the optimally oxygen doping procedure. In this work, the grain sizes of the oxygen annealed samples have been investigated by Scanning Electron Microscopy (SEM). Moreover, the magnetization data obtained via Superconducting Interference Quantum Device (SQUID) has been utilized for calculation of critical current density, which is essential parameter for determining Josephson penetration depth. The Josephson penetration depths of the systems have been calculated by Lawrence–Doniach Model for high temperature superconductors. Since plasma frequency of the system is inversely proportional to Josephson penetration depth, the plasma frequencies of the various doping profiles have also been calculated for the high temperature superconductor investigated.

  18. Probing the Universal Randall-Sundrum Model at the ILC

    CERN Document Server

    Davoudiasl, H; Rizzo, T G

    2005-01-01

    The Randall-Sundrum model with all Standard Model (SM) fields in the bulk, including the Higgs, can be probed by precision measurements at the ILC. In particular, the couplings of the Higgs to the gauge bosons of the SM can be determined with high accuracy at the ILC. Here we examine the deviations in these couplings from their SM values within the framework of the Universal Randall-Sundrum Model (URSM) as well as the corresponding couplings of the first Higgs Kaluza-Klein excitation.

  19. Beam Polarization at the ILC: Physics Case and Realization

    Science.gov (United States)

    Vauth, Annika; List, Jenny

    2016-02-01

    The International Linear Collider (ILC) is a proposed e+e- collider, focused on precision measurement of the Standard Model and new physics beyond. Polarized beams are a key element of the ILC physics program. The physics studies are accompanied by an extensive R&D program for the creation of the polarized beams and the measurement of their polarization. This contribution will review the advantages of using beam polarization and its technical aspects and realization, such as the creation of polarized beams and the measurement of the polarization.

  20. Manifestation of intrinsic defects in optical properties of self-organized opal photonic crystals

    Science.gov (United States)

    Vlasov; Astratov; Baryshev; Kaplyanskii; Karimov; Limonov

    2000-05-01

    Self-organized synthetic opals possessing a face centered cubic (fcc) lattice are promising for fabrication of a three-dimensional photonic crystal with a full photonic band gap in the visible. The fundamental limiting factor of this method is the large concentration of lattice defects and, especially, planar stacking faults, which are intrinsic to self-assembling growth of colloidal crystal. We have studied the influence of various types of defects on photonic band structure of synthetic opals by means of optical transmission, reflection and diffraction along different crystallographic directions. We found that in carefully chosen samples the stacking probability alpha can be as high as 0.8-0.9 revealing the strong preference of fcc packing sequence over the hexagonal close-packed (hcp). It is shown that scattering on plane stacking faults located perpendicular to the direction of growth results in a strong anisotropy of diffraction pattern as well as in appearance of a pronounced doublet structure in transmission and reflection spectra taken from the directions other than the direction of growth. This doublet is a direct manifestation of the coexistence of two crystallographic phases--pure fcc and strongly faulted. As a result the inhomogeneously broadened stop-bands overlap over a considerable amount of phase space. The latter, however, does not mean the depletion of the photonic density of states since large disordering results in filling of the partial gaps with both localized and extended states.

  1. Intrinsic point defects in zinc oxide. Modeling of structural, electronic, thermodynamic and kinetic properties

    Energy Technology Data Exchange (ETDEWEB)

    Erhart, P.

    2006-07-01

    The present dissertation deals with the modeling of zinc oxide on the atomic scale employing both quantum mechanical as well as atomistic methods. The first part describes quantum mechanical calculations based on density functional theory of intrinsic point defects in ZnO. To begin with, the geometric and electronic structure of vacancies and oxygen interstitials is explored. In equilibrium oxygen interstitials are found to adopt dumbbell and split interstitial configurations in positive and negative charge states, respectively. Semi-empirical self-interaction corrections allow to improve the agreement between the experimental and the calculated band structure significantly; errors due to the limited size of the supercells can be corrected by employing finite-size scaling. The effect of both band structure corrections and finite-size scaling on defect formation enthalpies and transition levels is explored. Finally, transition paths and barriers for the migration of zinc as well as oxygen vacancies and interstitials are determined. The results allow to interpret diffusion experiments and provide a consistent basis for developing models for device simulation. In the second part an interatomic potential for zinc oxide is derived. To this end, the Pontifix computer code is developed which allows to fit analytic bond-order potentials. The code is subsequently employed to obtain interatomic potentials for Zn-O, Zn-Zn, and O-O interactions. To demonstrate the applicability of the potentials, simulations on defect production by ion irradiation are carried out. (orig.)

  2. Exploiting Intrinsic Triangular Geometry in Relativistic He3+Au Collisions to Disentangle Medium Properties

    CERN Document Server

    Nagle, J L; Beckman, S; Koblesky, T; Koop, J Orjuela; McGlinchey, D; Romatschke, P; Carlson, J; Lynn, J; McCumber, M

    2013-01-01

    Recent results in d+Au and p+Pb collisions at RHIC and the LHC provide evidence for collective expansion and flow of the created medium. We propose a control set of experiments to directly compare particle emission patterns from p+Au, d+Au, and He3+Au or t+Au collisions at the same sqrt(sNN). Using Monte Carlo Glauber we find that a He3 or triton projectile, with a realistic wavefunction description, induces a significant intrinsic triangular shape to the initial medium and that, even with viscous damping, this survives into a significant third order flow moment v3. By comparing systems with one, two, and three initial hot spots, one can disentangle the effects from the initial spatial distribution of the deposited energy and viscous damping. These are key tools to answering the question of how small a droplet of matter is necessary to form a quark-gluon plasma described by nearly inviscid hydrodynamics.

  3. Reddening, Emission-Line, and Intrinsic Absorption Properties in the Narrow-Line Seyfert 1 Galaxy Akn 564

    CERN Document Server

    Crenshaw, D M; Turner, T J; Collier, S J; Peterson, B M; Brandt, W N; Clavel, J; George, I M; Horne, K; Kriss, G A; Mathur, S; Netzer, H; Pogge, R W; Pounds, K A; Romano, P; Shemmer, O; Wamsteker, W

    2002-01-01

    We use Hubble Space Telescope UV and optical spectra of the narrow-line Seyfert 1 (NLS1) galaxy Akn 564 to investigate its internal reddening and properties of its emission-line and intrinsic UV absorption gas. We find that the extinction curve of Akn 564, derived from a comparison of its UV/optical continuum to that of an unreddened NLS1, lacks a 2200 A bump and turns up towards the UV at a longer wavelength (4000 A) than the standard Galactic, LMC, and SMC curves. However, it does not show the extremely steep rise to 1200 A that characterizes the extinction curve of the Seyfert 1 galaxy NGC 3227. The emission-lines and continuum experience the same amount of reddening, indicating the presence of a dust screen that is external to the narrow-line region (NLR). Echelle spectra from the Space Telescope Imaging Spectrograph show intrinsic UV absorption lines due to Ly-alpha, N V, C IV, Si IV, and Si III, centered at a radial velocity of -190 km/s (relative to the host galaxy). Photoionization models of the UV ab...

  4. Electronic Properties of a 1D Intrinsic/p-Doped Heterojunction in a 2D Transition Metal Dichalcogenide Semiconductor

    KAUST Repository

    Song, Zhibo

    2017-07-28

    Two-dimensional (2D) semiconductors offer a convenient platform to study 2D physics, for example, to understand doping in an atomically thin semiconductor. Here, we demonstrate the fabrication and unravel the electronic properties of a lateral doped/intrinsic heterojunction in a single-layer (SL) tungsten diselenide (WSe2), a prototype semiconducting transition metal dichalcogenide (TMD), partially covered with a molecular acceptor layer, on a graphite substrate. With combined experiments and theoretical modeling, we reveal the fundamental acceptor-induced p-doping mechanism for SL-WSe2. At the 1D border between the doped and undoped SL-WSe2 regions, we observe band bending and explain it by Thomas-Fermi screening. Using atomically resolved scanning tunneling microscopy and spectroscopy, the screening length is determined to be in the few nanometer range, and we assess the carrier density of intrinsic SL-WSe2. These findings are of fundamental and technological importance for understanding and employing surface doping, for example, in designing lateral organic TMD heterostructures for future devices.

  5. Effect of caffeine on intrinsic mechanical properties of normal and malignant hyperthermia-susceptible muscle.

    Science.gov (United States)

    Metterlein, Thomas; Hartung, Edmund; Roewer, Norbert; Anetseder, Martin

    2015-10-01

    Malignant hyperthermia (MH) is a potentially lethal anesthesic complication. Pathological symptoms develop after exposure to triggering substances. It remains uncertain whether cellular alterations pre-exist. Mechanical properties of isolated muscle bundles were examined before and after exposure to a triggering substance. With prior written consent, muscle bundles of 12 MH-susceptible (MHS) and 56 MH-nonsusceptible (MHN) individuals were examined before and after exposure to incremental doses of caffeine. Mechanical properties (baseline tension, peak tension, time to peak tension, and relaxation time) were measured. Contraction and relaxation derivatives and contraction-relaxation coupling were calculated and analyzed. Mechanical properties were not different between the groups before caffeine application. Caffeine increased peak tension in both groups and baseline tension only in MHS muscle bundles; relaxation time/derivative and contraction-relaxation coupling were prolonged. Cellular changes seen in MH are not pre-existing. Exposure to triggering substance impairs relaxation in MHS muscle. © 2015 Wiley Periodicals, Inc.

  6. Insights into the Immunological Properties of Intrinsically Disordered Malaria Proteins Using Proteome Scale Predictions.

    Directory of Open Access Journals (Sweden)

    Andrew J Guy

    Full Text Available Malaria remains a significant global health burden. The development of an effective malaria vaccine remains as a major challenge with the potential to significantly reduce morbidity and mortality. While Plasmodium spp. have been shown to contain a large number of intrinsically disordered proteins (IDPs or disordered protein regions, the relationship of protein structure to subcellular localisation and adaptive immune responses remains unclear. In this study, we employed several computational prediction algorithms to identify IDPs at the proteome level of six Plasmodium spp. and to investigate the potential impact of protein disorder on adaptive immunity against P. falciparum parasites. IDPs were shown to be particularly enriched within nuclear proteins, apical proteins, exported proteins and proteins localised to the parasitophorous vacuole. Furthermore, several leading vaccine candidates, and proteins with known roles in host-cell invasion, have extensive regions of disorder. Presentation of peptides by MHC molecules plays an important role in adaptive immune responses, and we show that IDP regions are predicted to contain relatively few MHC class I and II binding peptides owing to inherent differences in amino acid composition compared to structured domains. In contrast, linear B-cell epitopes were predicted to be enriched in IDPs. Tandem repeat regions and non-synonymous single nucleotide polymorphisms were found to be strongly associated with regions of disorder. In summary, immune responses against IDPs appear to have characteristics distinct from those against structured protein domains, with increased antibody recognition of linear epitopes but some constraints for MHC presentation and issues of polymorphisms. These findings have major implications for vaccine design, and understanding immunity to malaria.

  7. Intrinsic dosimetry. Properties and mechanisms of thermoluminescence in commercial borosilicate glass

    Energy Technology Data Exchange (ETDEWEB)

    Clark, Richard A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2012-10-01

    Intrinsic dosimetry is the method of measuring total absorbed dose received by the walls of a container holding radioactive material. By considering the total absorbed dose received by a container in tandem with the physical characteristics of the radioactive material housed within that container, this method has the potential to provide enhanced pathway information regarding the history of the container and its radioactive contents. The latest in a series of experiments designed to validate and demonstrate this newly developed tool are reported. Thermoluminescence (TL) dosimetry was used to measure dose effects on raw stock borosilicate container glass up to 70 days after gamma ray, x-ray, beta particle or ultraviolet irradiations at doses from 0.15 to 20 Gy. The TL glow curve when irradiated with 60Co was separated into five peaks: two relatively unstable peaks centered near 120 and 165°C, and three relatively stable peaks centered near 225, 285, and 360°C. Depending on the borosilicate glass source, the minimum measurable dose using this technique is 0.15-0.5 Gy, which is roughly equivalent to a 24 hr irradiation at 1 cm from a 50-165 ng source of 60Co. Differences in TL glow curve shape and intensity were observed for the glasses from different geographical origins. These differences can be explained by changes in the intensities of the five peaks. Electron paramagnetic resonance (EPR) and multivariate statistical methods were used to relate the TL intensity and peaks to electron/hole traps and compositional variations.

  8. Mode I Fracture Toughness of Rock - Intrinsic Property or Pressure-Dependent?

    Science.gov (United States)

    Stoeckhert, F.; Brenne, S.; Molenda, M.; Alber, M.

    2016-12-01

    The mode I fracture toughness of rock is usually regarded as an intrinsic material parameter independent of pressure. However, most fracture toughness laboratory tests are conducted only at ambient pressure. To investigate fracture toughness of rock under elevated pressures, sleeve fracturing laboratory experiments were conducted with various rock types and a new numerical method was developed for the evaluation of these experiments. The sleeve fracturing experiments involve rock cores with central axial boreholes that are placed in a Hoek triaxial pressure cell to apply an isostatic confining pressure. A polymere tube is pressurized inside these hollow rock cylinders until they fail by tensile fracturing. Numerical simulations incorporating fracture mechanical models are used to obtain a relation between tensile fracture propagation and injection pressure. These simulations indicate that the magnitude of the injection pressure at specimen failure is only depending on the fracture toughness of the tested material, the specimen dimensions and the magnitude of external loading. The latter two are known parameters in the experiments. Thus, the fracture toughness can be calculated from the injection pressure recorded at specimen breakdown. All specimens had a borehole diameter to outer diameter ratio of about 1:10 with outer diameters of 40 and 62 mm. The length of the specimens was about two times the diameter. Maximum external loading was 7.5 MPa corresponding to maximum injection pressures at specimen breakdown of about 100 MPa. The sample set tested in this work includes Permian and Carboniferous sandstones, Jurassic limestones, Triassic marble, Permian volcanic rocks and Devonian slate from Central Europe. The fracture toughness values determined from the sleeve fracturing experiments without confinement using the new numerical method were found to be in good agreement with those from Chevron bend testing according to the ISRM suggested methods. At elevated

  9. Electroweak Theory for the Tevatron, LHC, and ILC

    CERN Document Server

    Erler, Jens

    2008-01-01

    Future high precision electroweak measurements require understanding of Standard Model expectations to multi-loop accuracy, both, for the predictions of production cross-sections of signal and background, as well as for pseudo-observables. I review recent results from precision calculations and summarize projections and implications for the Tevatron, the LHC, CEBAF, and the ILC.

  10. Present Status of the ILC Project and Development

    Energy Technology Data Exchange (ETDEWEB)

    Ross, M.; /Fermilab; Walker, N.; /DESY; Yamamoto, A.; /KEK, Tsukuba

    2011-09-01

    The Technical Design of the International Linear Collider (ILC) Project will be finished in late 2012. The Technical Design Report (TDR) will include a description of the updated design, with a cost estimate and a project plan, and the results of research and development (R & D) done in support of the ILC. Results from directed ILC R & D are used to reduce the cost and risk associated with the ILC design. We present a summary of key challenges and show how the global R & D effort has addressed them. The most important activity has been in pursuit of very high gradient superconducting RF linac technology. There has been excellent progress toward the goal of practical industrial production of niobium sheet-metal cavities with gradient performance in excess of 35 MV/m. In addition, three purpose-built beam test facilities have been constructed and used to study and demonstrate high current linac performance, electron-cloud beam dynamics and precision beam control. The report also includes a summary of component design studies and conventional facilities cost optimization design studies.

  11. An Intestinal Inflammasome - The ILC3-Cytokine Tango.

    Science.gov (United States)

    Gonçalves, Pedro; Di Santo, James P

    2016-04-01

    The inflammasome is a key regulator of immune responses in the gut. Two recent studies in the journal Cell demonstrate that epithelial inflammasome activation and IL-18 secretion can control intestinal homeostasis or induce autoinflammation. ILC3 cells are triggered to secrete IL-22, regulating IL-18 expression in epithelial cells, in turn modulating homeostasis and inflammation.

  12. Post LHC7 SUSY benchmark points for ILC physics

    Energy Technology Data Exchange (ETDEWEB)

    Baer, Howard [Oklahoma Univ., Norman, OK (United States); List, Jenny [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2012-05-15

    We re-evaluate prospects for supersymmetry at the proposed International Linear e{sup +}e{sup -} Collider (ILC) in light of the first year of serious data taking at LHC with {radical}(s)=7 TeV and {proportional_to}5 fb{sup -1} of pp collisions (LHC7). Strong new limits from LHC SUSY searches, along with a hint of a Higgs boson signal around m{sub h}{proportional_to}125 GeV, suggest a paradigm shift from previously popular models to ones with new and compelling signatures. We present a variety of new ILC benchmark models, including: natural SUSY, hidden SUSY, NUHM2 with low m{sub A}, non-universal gaugino mass (NUGM) model, pMSSM, Kallosh-Linde model, Bruemmer-Buchmueller model, normal scalar mass hierarchy (NMH) plus one surviving case from mSUGRA/CMSSM in the far focus point region. While all these models at present elude the latest LHC limits, they do offer intriguing case study possibilities for ILC operating at {radical}(s){proportional_to}0.25-1 TeV, and present a view of some of the diverse SUSY phenomena which might be expected at both LHC and ILC in the post LHC7 era.

  13. DSiD: a Delphes Detector for ILC Physics Studies

    CERN Document Server

    Potter, C T

    2016-01-01

    We describe DSiD, a fast simulation Delphes detector for the International Linear Collider (ILC) based on the full simulation performance of the SiD detector. SiD is one of two detectors described in the ILC Technical Design Report (TDR). The tracking efficiency, tracking momentum resolution, electromagnetic and hadronic calorimeter energy resolution, particle identification and flavor tagging efficiencies are taken from the Detailed Baseline Design (DBD) study as described in ILC TDR Volume 4: Detectors. In a cross-check study with $4 \\times 10^6$ $e^+ e^- \\rightarrow b \\bar{b}$ events generated at $\\sqrt{s}=500$ GeV and simulated by Delphes with the DSiD detector card, these performance characteristics are measured and found to be commensurate with the DBD results. For a new physics use case example, we describe a study of Next-to-Minimal Supersymmetric $e^+ e^- \\rightarrow 2 \\chi_3 \\rightarrow 2\\chi_1 2 h_1$ with $h_1 \\rightarrow 2a_1$ or $h_1 \\rightarrow b\\bar{b}$ at the $\\sqrt{s}=500$ GeV ILC. The card i...

  14. Intrinsic structure and friction properties of graphene and graphene oxide nanosheets studied by scanning probe microscopy

    Indian Academy of Sciences (India)

    Yan-Huai Ding; Hu-Ming Ren; Fei-Hu Chang; Ping Zhang; Yong Jiang

    2013-11-01

    In this paper, atomic structure of single-layered graphene oxide (GO) and chemically reduced graphene oxide (CRGO) nanosheets was investigated using atomic force microscopy and scanning tunnelingmicroscopy (AFM and STM). Furthermore, friction properties of the graphene and GO nanosheets were studied by frictional force microscopy (FFM). STM imaging provided direct evidence and the morphology was influenced by oxygen-containing groups and defects. The atomic scale structural disorder in a hexagonal two-dimensional network of carbon atoms changes the surface condition, which also caused the frictional property variations of the samples.

  15. Contributions of intrinsic motor neuron properties to the production of rhythmic motor output in the mammalian spinal cord

    DEFF Research Database (Denmark)

    Kiehn, O; Kjaerulff, O; Tresch, M C

    2000-01-01

    Motor neurons are endowed with intrinsic and conditional membrane properties that may shape the final motor output. In the first half of this paper we present data on the contribution of I(h), a hyperpolarization-activated inward cation current, to phase-transition in motor neurons during rhythmic...... firing. Motor neurons were recorded intracellularly during locomotion induced with a mixture of N-methyl-D-aspartate (NMDA) and serotonin, after pharmacological blockade of I(h). I(h) was then replaced by using dynamic clamp, a computer program that allows artificial conductances to be inserted into real...... neurons. I(h) was simulated with biophysical parameters determined in voltage clamp experiments. The data showed that electronic replacement of the native I(h) caused a depolarization of the average membrane potential, a phase-advance of the locomotor drive potential, and increased motor neuron spiking...

  16. Intrinsic Properties and Structure of AB2 Laves Phase ZrW2

    Science.gov (United States)

    Wu, Junyan; Zhang, Bo; Zhan, Yongzhong

    2017-06-01

    Using the first-principle calculations along with the quasi-harmonic Debye model, we explore the structural, thermodynamic, mechanical, and electronic properties of ZrW2 intermetallic considering temperature or pressure effect. The computed equilibrium lattice parameter here is highly consistent with previous available results. The obtained formation enthalpy reveals that the ZrW2 is structurally stable in the pressure range of 0 to 100 GPa. The pressure and temperature dependences of V/ V 0 ratio, constant volume specific heat capacity, thermal expansion coefficient, and Debye temperature of ZrW2 have been obtained. The calculated minimum thermal conductivity k min of ZrW2 is fairly small and shows anisotropy, which implies that ZrW2 has promising thermal-insulating application in engineering and may be competent for the thermal barrier materials. Moreover, from the results of elastic properties, we found the ZrW2 is mechanically stable and exhibits elastic anisotropy and the extent of elastic anisotropy increases with pressure. Additionally, ZrW2 shows ductile nature and its mechanical moduli all enhance as pressure increases, which is further confirmed by the findings from the electronic properties.

  17. Translating innate response into long-lasting antibody response by the intrinsic antigen-adjuvant properties of papaya mosaic virus.

    Science.gov (United States)

    Acosta-Ramírez, Elizabeth; Pérez-Flores, Rebeca; Majeau, Nathalie; Pastelin-Palacios, Rodolfo; Gil-Cruz, Cristina; Ramírez-Saldaña, Maricela; Manjarrez-Orduño, Nataly; Cervantes-Barragán, Luisa; Santos-Argumedo, Leopoldo; Flores-Romo, Leopoldo; Becker, Ingeborg; Isibasi, Armando; Leclerc, Denis; López-Macías, Constantino

    2008-06-01

    Identifying the properties of a molecule involved in the efficient activation of the innate and adaptive immune responses that lead to long-lasting immunity is crucial for vaccine and adjuvant development. Here we show that the papaya mosaic virus (PapMV) is recognized by the immune system as a pathogen-associated molecular pattern (PAMP) and as an antigen in mice (Pamptigen). A single immunization of PapMV without added adjuvant efficiently induced both cellular and specific long-lasting antibody responses. PapMV also efficiently activated innate immune responses, as shown by the induction of lipid raft aggregation, secretion of pro-inflammatory cytokines, up-regulation of co-stimulatory molecules on dendritic cells and macrophages, and long-lasting adjuvant effects upon the specific antibody responses to model antigens. PapMV mixed with Salmonella enterica serovar Typhi (S. typhi) outer membrane protein C increased its protective capacity against challenge with S. typhi, revealing the intrinsic adjuvant properties of PapMV in the induction of immunity. Antigen-presenting cells loaded with PapMV efficiently induced antibody responses in vivo, which may link the innate and adaptive responses observed. PapMV recognition as a Pamptigen might be translated into long-lasting antibody responses and protection observed. These properties could be used in the development of new vaccine platforms.

  18. Intrinsic membrane properties determine hippocampal differential firing pattern in vivo in anesthetized rats.

    Science.gov (United States)

    Kowalski, Janina; Gan, Jian; Jonas, Peter; Pernía-Andrade, Alejandro J

    2016-05-01

    The hippocampus plays a key role in learning and memory. Previous studies suggested that the main types of principal neurons, dentate gyrus granule cells (GCs), CA3 pyramidal neurons, and CA1 pyramidal neurons, differ in their activity pattern, with sparse firing in GCs and more frequent firing in CA3 and CA1 pyramidal neurons. It has been assumed but never shown that such different activity may be caused by differential synaptic excitation. To test this hypothesis, we performed high-resolution whole-cell patch-clamp recordings in anesthetized rats in vivo. In contrast to previous in vitro data, both CA3 and CA1 pyramidal neurons fired action potentials spontaneously, with a frequency of ∼3-6 Hz, whereas GCs were silent. Furthermore, both CA3 and CA1 cells primarily fired in bursts. To determine the underlying mechanisms, we quantitatively assessed the frequency of spontaneous excitatory synaptic input, the passive membrane properties, and the active membrane characteristics. Surprisingly, GCs showed comparable synaptic excitation to CA3 and CA1 cells and the highest ratio of excitation versus hyperpolarizing inhibition. Thus, differential synaptic excitation is not responsible for differences in firing. Moreover, the three types of hippocampal neurons markedly differed in their passive properties. While GCs showed the most negative membrane potential, CA3 pyramidal neurons had the highest input resistance and the slowest membrane time constant. The three types of neurons also differed in the active membrane characteristics. GCs showed the highest action potential threshold, but displayed the largest gain of the input-output curves. In conclusion, our results reveal that differential firing of the three main types of hippocampal principal neurons in vivo is not primarily caused by differences in the characteristics of the synaptic input, but by the distinct properties of synaptic integration and input-output transformation.

  19. Mechanical properties of organic semiconductors for mechanically stable and intrinsically stretchable solar cells (Conference Presentation)

    Science.gov (United States)

    Lipomi, Darren J.

    2016-09-01

    This presentation describes my group's efforts to understand the molecular and microstructural basis for the mechanical properties of organic semiconductors for organic photovoltaic (OPV) devices. Our work is motivated by two goals. The first goal is to mitigate mechanical forms of degradation of printed modules during roll-to-roll fabrication, installation, and environmental forces—i.e., wind, rain, snow, and thermal expansion and contraction. Mechanical stability is a prerequisite for inexpensive processing on flexible substrates: to encapsulate devices in glass is to surrender this advantage. The second goal is to enable the next generation of ultra-flexible and stretchable solar cells for collapsible, portable, and wearable applications, and as low-cost sources of energy—"solar tarps"—for disaster relief and for the developing world. It may seem that organic semiconductors, due to their carbon framework, are already sufficiently compliant for these applications. We have found, however, that the mechanical properties (stiffness and brittleness) occupy a wide range of values, and can be difficult to predict from molecular structure alone. We are developing an experimental and theoretical framework for how one can combine favorable charge-transport properties and mechanical compliance in organic semiconductor films. In particular, we have explored the roles of the backbone, alkyl side chain, microstructural order, the glass transition, molecular packing with fullerenes, plasticizing effects of additives, extent of separation of [60]PCBM and [70]PCBM, structural randomness in low-bandgap polymers, and reinforcement by encapsulation, on the mechanical compliance. We are exploring the applicability of semi-empirical "back-of-the-envelope" models, along with multi-scale molecular dynamics simulations, with the ultimate goal of designing electroactive organic materials whose mechanical properties can be dialed-in. We have used the insights we have developed to

  20. Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method

    Science.gov (United States)

    Adamcik, Jozef; Lara, Cecile; Usov, Ivan; Jeong, Jae Sun; Ruggeri, Francesco S.; Dietler, Giovanni; Lashuel, Hilal A.; Hamley, Ian W.; Mezzenga, Raffaele

    2012-07-01

    We report the investigation of the mechanical properties of different types of amyloid fibrils by the peak force quantitative nanomechanical (PF-QNM) technique. We demonstrate that this technique correctly measures the Young's modulus independent of the polymorphic state and the cross-sectional structural details of the fibrils, and we show that values for amyloid fibrils assembled from heptapeptides, α-synuclein, Aβ(1-42), insulin, β-lactoglobulin, lysozyme, ovalbumin, Tau protein and bovine serum albumin all fall in the range of 2-4 GPa.

  1. Quantity of Matter or Intrinsic Property: Why Mass Cannot Be Both

    CERN Document Server

    Hubert, Mario

    2015-01-01

    I analyze the meaning of mass in Newtonian mechanics. First, I explain the notion of primitive ontology, which was originally introduced in the philosophy of quantum mechanics. Then I examine the two common interpretations of mass: mass as a measure of the quantity of matter and mass as a dynamical property. I claim that the former is ill-defined, and the latter is only plausible with respect to a metaphysical interpretation of laws of nature. I explore the following options for the status of laws: Humeanism, primitivism about laws, dispositionalism, and ontic structural realism.

  2. Intrinsic Magnetism and Collective Magnetic Properties of Size-Selected Nanoparticles

    Science.gov (United States)

    Antoniak, C.; Friedenberger, N.; Trunova, A.; Meckenstock, R.; Kronast, F.; Fauth, K.; Farle, M.; Wende, H.

    Using size-selected spherical FePt nanoparticles and cubic Fe/Fe-oxide nanoparticles as examples, we discuss the recent progress in the determination of static and dynamic properties of nanomagnets. Synchroton radiation-based characterisation techniques in combination with detailed structural, chemical and morphological investigations by transmission and scanning electron microscopy allow the quantitative correlation between element-specific magnetic response and spin structure on the one hand and shape, crystal and electronic structure of the particles on the other hand. Examples of measurements of element-specific hysteresis loops of single 18 nm sized nanocubes are discussed. Magnetic anisotropy of superparamagnetic ensembles and their dynamic magnetic response are investigated by ferromagnetic resonance as a function of temperature at different microwave frequencies. Such investigations allow the determination of the magnetic relaxation and the extraction of the average magnetic anisotropy energy density of the individual particles.

  3. Characterization of neuronal intrinsic properties and synaptic transmission in layer I of anterior cingulate cortex from adult mice

    Directory of Open Access Journals (Sweden)

    Li Xiang-Yao

    2012-07-01

    Full Text Available Abstract The neurons in neocortex layer I (LI provide inhibition to the cortical networks. Despite increasing use of mice for the study of brain functions, few studies were reported about mouse LI neurons. In the present study, we characterized intrinsic properties of LI neurons of the anterior cingulate cortex (ACC, a key cortical area for sensory and cognitive functions, by using whole-cell patch clamp recording approach. Seventy one neurons in LI and 12 pyramidal neurons in LII/III were recorded. Although all of the LI neurons expressed continuous adapting firing characteristics, the unsupervised clustering results revealed five groups in the ACC, including: Spontaneous firing neurons; Delay-sAHP neurons, Delay-fAHP neurons, and two groups of neurons with ADP, named ADP1 and ADP2, respectively. Using pharmacological approaches, we found that LI neurons received both excitatory (mediated by AMPA, kainate and NMDA receptors, and inhibitory inputs (which were mediated by GABAA receptors. Our studies provide the first report characterizing the electrophysiological properties of neurons in LI of the ACC from adult mice.

  4. Differences in synaptic and intrinsic properties result in topographic heterogeneity of temporal processing of neurons within the inferior colliculus.

    Science.gov (United States)

    Yassin, Lina; Pecka, Michael; Kajopoulos, Jasmin; Gleiss, Helge; Li, Lu; Leibold, Christian; Felmy, Felix

    2016-11-01

    The identification and characterization of organization principals is essential for the understanding of neural function of brain areas. The inferior colliculus (IC) represents a midbrain nexus involved in numerous aspects of auditory processing. Likewise, neurons throughout the IC are tuned to a diverse range of specific stimulus features. Yet beyond a topographic arrangement of the cochlea-inherited frequency tuning, the functional organization of the IC is not well understood. Particularly, a common principle that links the diverse tuning characteristics is unknown. Here we used in vitro patch clamp recordings combined with laser-uncaging, and in vivo single cell recordings to study the spatial and functional organization principles of the central IC. We identified a topographic bias of ascending synaptic input timing that is balanced between inhibition and excitation and co-varies with in vivo first-spike latency. This bias was paralleled post-synaptically by differences in biophysical membrane properties and firing patterns, with integrating neurons predominantly found in the dorso-medial part, and coincidence-detector neurons biased to the ventro-lateral IC. Importantly, these cellular and network features translated into distinct temporal processing capabilities irrespectively of the neurons' characteristic frequency. Our data therefore imply that heterogeneity of synaptic inputs, intrinsic properties and temporal processing are functional principles that underlie the spatial organization of the central IC.

  5. Self-organization is a dynamic and lineage-intrinsic property of mammary epithelial cells

    Energy Technology Data Exchange (ETDEWEB)

    Chanson, L. [Ecole Polytechnique Federale de Lausanne (Switzerland). Inst. of Bioengineering; Brownfield, D. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Life Sciences Div.; Univ. of California, Berkeley, CA (United States). Dept. of Bioengineering; Garbe, J. C. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Life Sciences Div.; Kuhn, I. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Life Sciences Div.; Stampfer, M. R. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Life Sciences Div.; Bissell, M. J. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Life Sciences Div.; LaBarge, M. A. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Life Sciences Div.

    2011-02-07

    Loss of organization is a principle feature of cancers; therefore it is important to understand how normal adult multilineage tissues, such as bilayered secretory epithelia, establish and maintain their architectures. The self-organization process that drives heterogeneous mixtures of cells to form organized tissues is well studied in embryology and with mammalian cell lines that were abnormal or engineered. Here we used a micropatterning approach that confined cells to a cylindrical geometry combined with an algorithm to quantify changes of cellular distribution over time to measure the ability of different cell types to self-organize relative to each other. Using normal human mammary epithelial cells enriched into pools of the two principal lineages, luminal and myoepithelial cells, we demonstrated that bilayered organization in mammary epithelium was driven mainly by lineage-specific differential E-cadherin expression, but that P-cadherin contributed specifically to organization of the myoepithelial layer. Disruption of the actomyosin network or of adherens junction proteins resulted in either prevention of bilayer formation or loss of preformed bilayers, consistent with continual sampling of the local microenvironment by cadherins. Together these data show that self-organization is an innate and reversible property of communities of normal adult human mammary epithelial cells.

  6. Non-random genomic integration - an intrinsic property of retrogenes in Drosophila?

    Directory of Open Access Journals (Sweden)

    Metta Muralidhar

    2010-04-01

    Full Text Available Abstract Background The Drosophila X-chromosome shows a significant underrepresentation of genes with male-biased gene expression (demasculinization. This trend is matched by retrogenes, which typically have a male biased gene expression pattern and show a significant movement bias from X-chromosomes to autosomes. It is currently assumed that these patterns are best explained by selection, either mediated by male meiotic sex chromosome inactivation (MSCI or sexually antagonistic forces. We scrutinized the evolutionary dynamics of retroposition by focusing on retrogenes for which the parental copy has degenerated. Results Consistent with a functional substitution of the degenerated gene by the retrogene, patterns of sequence evolution and gene expression were similar between retroposed and parental genes. Like previous studies, our set of retrogenes showed a significant movement off the X-chromosome. In contrast to data sets where retroposition caused gene duplication, the genes in our study showed primarily female-biased or unbiased gene expression. Conclusions Based on our results, the biased transposition pattern cannot be explained by MSCI and probably not by sexual antagonism. Rather, we propose that the movement away from the X-chromosome represents a general property of retroposition in Drosophila.

  7. Self-organization is a dynamic and lineage-intrinsic property of mammary epithelial cells

    Science.gov (United States)

    Chanson, Lea; Brownfield, Douglas; Garbe, James C.; Kuhn, Irene; Stampfer, Martha R.; Bissell, Mina J.; LaBarge, Mark A.

    2011-01-01

    Loss of organization is a principle feature of cancers; therefore it is important to understand how normal adult multilineage tissues, such as bilayered secretory epithelia, establish and maintain their architectures. The self-organization process that drives heterogeneous mixtures of cells to form organized tissues is well studied in embryology and with mammalian cell lines that were abnormal or engineered. Here we used a micropatterning approach that confined cells to a cylindrical geometry combined with an algorithm to quantify changes of cellular distribution over time to measure the ability of different cell types to self-organize relative to each other. Using normal human mammary epithelial cells enriched into pools of the two principal lineages, luminal and myoepithelial cells, we demonstrated that bilayered organization in mammary epithelium was driven mainly by lineage-specific differential E-cadherin expression, but that P-cadherin contributed specifically to organization of the myoepithelial layer. Disruption of the actomyosin network or of adherens junction proteins resulted in either prevention of bilayer formation or loss of preformed bilayers, consistent with continual sampling of the local microenvironment by cadherins. Together these data show that self-organization is an innate and reversible property of communities of normal adult human mammary epithelial cells. PMID:21300877

  8. Design studies and sensor tests for the beam calorimeter of the ILC detector

    Energy Technology Data Exchange (ETDEWEB)

    Kuznetsova, E.

    2007-03-15

    The International Linear Collider (ILC) is being designed to explore particle physics at the TeV scale. The design of the Very Forward Region of the ILC detector is considered in the presented work. The Beam Calorimeter - one of two electromagnetic calorimeters situated there - is the subject of this thesis. The Beam Calorimeter has to provide a good hermeticity for high energy electrons, positrons and photons down to very low polar angles, serve for fast beam diagnostics and shield the inner part of the detector from backscattered beamstrahlung remnants and synchrotron radiation. As a possible technology for the Beam Calorimeter a diamond-tungsten sandwich calorimeter is considered. Detailed simulation studies are done in order to explore the suitability of the considered design for the Beam Calorimeter objectives. Detection efficiency, energy and angular resolution for electromagnetic showers are studied. At the simulation level the diamondtungsten design is shown to match the requirements on the Beam Calorimeter performance. Studies of polycrystalline chemical vapour deposition (pCVD) diamond as a sensor material for the Beam Calorimeter are done to explore the properties of the material. Results of the measurements performed with pCVD diamond samples produced by different manufacturers are presented. (orig.)

  9. Scrutinizing h(125) in Two Higgs Doublet Models at the LHC, ILC, and Muon Collider

    CERN Document Server

    Barger, Vernon; Logan, Heather E; Shaughnessy, Gabe

    2013-01-01

    The discovery at the LHC of a scalar particle with properties that are so far consistent with the SM Higgs boson is one of the most important advances in the history of particle physics. The challenge of future collider experiments is to determine whether its couplings will show deviations from the SM Higgs, as this would indicate new physics at the TeV scale, and also to probe the flavor structure of the Yukawa couplings. As a benchmark alternative to the SM Higgs, we consider a generic two Higgs doublet model (2HDM) and analyze the precision to which the LHC14, an ILC250, 500, 1000 GeV and a 125 GeV Muon Collider (MC) can determine the gauge and Yukawa couplings. We allow for correlations among the couplings. We include the impact of a Higgs total width measurement, indirectly at the LHC and ILC and by a direct scan at the MC. We also discuss pattern relations among the couplings that can test for singlet or doublet Higgs extensions of 2HDMs.

  10. Cryogenic performance of a conduction-cooling splittable quadrupole magnet for ILC cryomodules

    Energy Technology Data Exchange (ETDEWEB)

    Kimura, N.; Yamamoto, A. [High Energy Accelerator Research Organization (KEK), 1-1 Oho, Tsukuba, Ibaraki 305-0801 (Japan); Andreev, N.; Kashikhin, V. S.; Tartaglia, M. A. [Fermi National Accelerator Laboratory, P.O. Box 500, Batavia, IL 60510 (United States); Kerby, J. [Argonne National Laboratory, Argonne, 9700 S. Cass Avenue, IL 60439 (United States); Takahashi, M.; Tosaka, T. [Toshiba Corporation Power Systems Company, 2-4 Suehiro-Cho, Tsurumi-Ku, Yokohama, Kanagawa 230-0045 (Japan)

    2014-01-29

    A conduction-cooled splittable superconducting quadrupole magnet was designed and fabricated at Fermilab for use in cryomodules of the International Linear Collider (ILC) type, in which the magnet was to be assembled around the beam tube to avoid contaminating the ultraclean superconducting radio frequency cavity volume. This quadrupole was first tested in a liquid helium bath environment at Fermilab, where its quench and magnetic properties were characterized. Because the device is to be cooled by conduction when installed in cryomodules, a separate test with a conduction-cooled configuration was planned at KEK and Fermilab. The magnet was converted to a conduction-cooled configuration by adding conduction-cooling passages made of high-purity aluminum. Efforts to convert and refabricate the magnet into a cryostat equipped with a double-stage pulse-tube-type cryocooler began in 2011, and a thermal performance test, including a magnet excitation test of up to 30 A, was conducted at KEK. In this test, the magnet with the conduction-cooled configuration was successfully cooled to 4 K within 190 h, with an acceptable heat load of less than 1 W at 4 K. It was also confirmed that the conduction-cooled splittable superconducting quadrupole magnet was practical for use in ILC-type cryomodules.

  11. Cryogenic performance of a conduction-cooling splittable quadrupole magnet for ILC cryomodules

    Science.gov (United States)

    Kimura, N.; Andreev, N.; Kashikhin, V. S.; Kerby, J.; Takahashi, M.; Tartaglia, M. A.; Tosaka, T.; Yamamoto, A.

    2014-01-01

    A conduction-cooled splittable superconducting quadrupole magnet was designed and fabricated at Fermilab for use in cryomodules of the International Linear Collider (ILC) type, in which the magnet was to be assembled around the beam tube to avoid contaminating the ultraclean superconducting radio frequency cavity volume. This quadrupole was first tested in a liquid helium bath environment at Fermilab, where its quench and magnetic properties were characterized. Because the device is to be cooled by conduction when installed in cryomodules, a separate test with a conduction-cooled configuration was planned at KEK and Fermilab. The magnet was converted to a conduction-cooled configuration by adding conduction-cooling passages made of high-purity aluminum. Efforts to convert and refabricate the magnet into a cryostat equipped with a double-stage pulse-tube-type cryocooler began in 2011, and a thermal performance test, including a magnet excitation test of up to 30 A, was conducted at KEK. In this test, the magnet with the conduction-cooled configuration was successfully cooled to 4 K within 190 h, with an acceptable heat load of less than 1 W at 4 K. It was also confirmed that the conduction-cooled splittable superconducting quadrupole magnet was practical for use in ILC-type cryomodules.

  12. Charges in the cytoplasmic pore control intrinsic inward rectification and single-channel properties in Kir1.1 and Kir2.1 channels.

    Science.gov (United States)

    Chang, Hsueh-Kai; Yeh, Shih-Hao; Shieh, Ru-Chi

    2007-02-01

    An E224G mutation of the Kir2.1 channel generates intrinsic inward rectification and single-channel fluctuations in the absence of intracellular blockers. In this study, we showed that positively charged residues H226, R228 and R260, near site 224, regulated the intrinsic inward rectification and single-channel properties of the E224G mutant. By carrying out systematic mutations, we found that the charge effect on the intrinsic inward rectification and single-channel conductance is consistent with a long-range electrostatic mechanism. A Kir1.1 channel where the site equivalent to E224 in the Kir2.1 channel is a glycine residue does not show inward rectification or single-channel fluctuations. The G223K and N259R mutations of the Kir1.1 channel induced intrinsic inward rectification and reduced the single-channel conductance but did not generate large open-channel fluctuations. Substituting the cytoplasmic pore of the E224G mutant into the Kir1.1 channel induced open-channel fluctuations and intrinsic inward rectification. The single-channel conductance of the E224G mutant showed inward rectification. Also, a voltage-dependent gating mechanism decreased open probability during depolarization and contributed to the intrinsic inward rectification in the E224G mutant. In addition to an electrostatic effect, a close interaction of K(+) with channel pore may be required for generating open-channel fluctuations in the E224G mutant.

  13. Intrinsic thermodynamic and kinetic properties of Sb electrodes for Li-ion and Na-ion batteries: Experiment and Theory

    Energy Technology Data Exchange (ETDEWEB)

    Baggetto, Loic [ORNL; Ganesh, Panchapakesan [ORNL; Sun, Che Nan [ORNL; Meisner, Roberta Ann [ORNL; Zawodzinski, Thomas A [ORNL; Veith, Gabriel M [ORNL

    2013-01-01

    energy barrier for near-neighbor vacancy motion, predominant in these close-packed phases is about twice for Na than for Li. Our analysis tries to relate the lower intrinsic diffusivity of Na compared to Li with the long-range strain propagation induced by the former, thereby leading to an intrinsic origin of differences in rates, mechanical properties and amorphization. Finally, the surface chemistry of Sb electrodes cycled in NaClO4 dissolved in pure PC with(out) the addition of 5wt% EC or FEC shows presence of ethers and NaF for the EC- and FEC-based electrolytes, respectively, and SEI films rich in Na-based carbonates.

  14. Curing behaviors and properties of an extrinsic toughened epoxy/anhydride system and an intrinsic toughened epoxy/anhydride system

    Energy Technology Data Exchange (ETDEWEB)

    Fan, Mengjin; Liu, Jialin; Li, Xiangyuan [Key Laboratory of Carbon Fiber and Functional Polymers, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029 (China); Cheng, Jue, E-mail: chengjue@mail.buct.edu.cn [Key Laboratory of Carbon Fiber and Functional Polymers, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029 (China); Zhang, Junying, E-mail: zjybuct@gmail.com [Key Laboratory of Carbon Fiber and Functional Polymers, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029 (China)

    2013-02-20

    Highlights: ► Two curing systems (ETRS and ITRS) with similar chemical composite were prepared. ► The curing kinetics of the ETRS and the novel ITRS were comparatively studied. ► Crosslinking density can affect the kinetic schemes of the two curing systems. ► Their mechanical properties and thermal stabilities were also comparatively studied. ► Crosslinking density may play an influential role in mechanical properties. - Abstract: The curing kinetics of an extrinsic toughened epoxy (mixture of diglycidyl ether of bisphenol-A and 1,4-butanediol epoxy resin, DGEBA/DGEBD) and an intrinsic toughened epoxy (ethoxylated bisphenol-A epoxy resin with two oxyethylene units, DGEBAEO-2) using hexahydrophthalic anhydride (HHPA) as curing agent and tris-(dimethylaminomethyl) phenol (DMP-30) as accelerator were comparatively studied by non-isothermal DSC with a model-fitting Málek approach and a model-free advanced isoconversional method of Vyazovkin. The dynamic mechanical properties and thermal stabilities of the cured materials were investigated by DMTA and TGA, respectively. The results showed that Šesták–Berggren model can generally simulate well the reaction rates of these two systems. The activation energy of DGEBA/DGEBD/HHPA/DMP-30 at high fractional conversion changed much higher than that of DGEBAEO-2/HHPA/DMP-30, indicating the increased steric hindrance mainly affected the reaction kinetic scheme of DGEBA/DGEBD/HHPA/DMP-30. The T{sub g} and storage moduli of cured DGEBAEO-2/HHPA/DMP-30 were lower than those of cured DGEBA/DGEBD/HHPA/DMP-30 according to DMTA while TGA showed that the thermal stabilities of these two cured systems were similar.

  15. Electroweak radiative corrections to triple photon production at the ILC

    CERN Document Server

    Zhang, Yu; Duan, Peng-Fei; Song, Mao; Li, Gang

    2016-01-01

    In this paper, we present the precision predictions for three photon production in the standard model (SM) at the ILC including the full next-to-leading (NLO) electroweak (EW) corrections, high order initial state radiation (h.o.ISR) contributions and beamstrahlung effects. We present the LO and the NLO EW+h.o.ISR+beamstrahlung corrected total cross sections for various colliding energy when $\\sqrt s \\ge 200 {\\rm GeV}$ and the kinematic distributions of final photons with $\\sqrt s = 500 {\\rm GeV}$ at ILC, and find that the NLO EW corrections, the h.o.ISR contributions and the beamstrahlung effects are important in exploring the process $e^+e^- \\to \\gamma\\gamma\\gamma$.

  16. Electroweak radiative corrections to triple photon production at the ILC

    Science.gov (United States)

    Zhang, Yu; Li, Wei-Hua; Duan, Peng-Fei; Song, Mao; Li, Gang

    2016-07-01

    In this paper, we present the precision predictions for three photon production in the standard model (SM) at the ILC including the full next-to-leading (NLO) electroweak (EW) corrections, high order initial state radiation (h.o.ISR) contributions and beamstrahlung effects. We present the LO and the NLO EW + h.o.ISR + beamstrahlung corrected total cross sections for various colliding energy when √{ s} ≥ 200 GeV and the kinematic distributions of final photons with √{ s} = 500 GeV at ILC, and find that the NLO EW corrections, the h.o.ISR contributions and the beamstrahlung effects are important in exploring the process e+e- → γγγ.

  17. Mechanical stability study of type IV cryomodule (ILC prototype)

    Energy Technology Data Exchange (ETDEWEB)

    McGee, M.W.; Doremus, R.; Wands, C.R.; /Fermilab

    2007-06-01

    An ANSYS modal and harmonic finite element analysis (FEA) was performed in order to investigate cryomodule design mechanical stability for the proposed International Linear Collider (ILC). The current cryomodule, designated Type IV or (T4CM), closely follows the Type III TESLA Test Facility (TTF) version used at DESY, with the exception of a proposed location of the superconducting (SC) quadrupole at the center. This analysis considered the stringent stability criteria established for the ILC, where vertical motion for the SC quadrupole is limited to the micron range at a few Hz. Model validation was achieved through Type III cryomodule vibration measurement studies performed at DESY. The effect of support location, support stiffness and other important parameters were considered in a parametric sensitivity study. FEA results, fast motion investigations and stabilization techniques are discussed.

  18. Solid State Modulators for the International Linear Collider (ILC)

    CERN Document Server

    Kempkes, Michael; Casey, Jeffrey; Gaudreau, Marcel; Roth, Ian

    2005-01-01

    Diversified Technologies, Inc. is developing two solid state modulator designs for the ILC under SBIR funding from the DOE. The first design consists of a 150 kV hard switch. The key development in this design is the energy storage system, which must provide 25 kJ per pulse, at very tight voltage regulation over the 1.5 millisecond pulse. DTI's design uses a quasi-resonant bouncer (with a small auxiliary power supply and switch) to maintain the voltage flattop, eliminating the need for massive capacitor banks. The second design uses a solid state Marx bank, with ~10 kV stages, to drive the ILC klystron. In this design, staggered turn-on of the Marx stages provides voltage regulation without the need for large capacitor banks. This paper will discuss design tradeoffs, power supply and control considerations, and energy storage requirements and alternatives for both designs.

  19. Neutralino relic density from ILC measurements in the CPV MSSM

    CERN Document Server

    Bélanger, G; Kraml, Sabine; Martyn, H -U; Pukhov, A

    2008-01-01

    We discuss ILC measurements for a specific MSSM scenario with CP phases, where the lightest neutralino is a good candidate for dark matter, annihilating efficiently through t-channel exchange of light staus. These prospective (CP-even) ILC measurements are then used to fit the underlying model parameters. A collider prediction of the relic density of the neutralino from this fit gives 0.116

  20. The ILC Beam Delivery System - Conceptual Design and RD Plans

    Energy Technology Data Exchange (ETDEWEB)

    Seryi, Andrei; /SLAC

    2005-05-27

    The Beam Delivery System of the ILC has many stringent and sometimes conflicting requirements. To produce luminosity, the beams must be focused to nanometer size. To provide acceptable detector backgrounds, particles far from the beam core must be collimated. Unique beam diagnostics and instrumentation are required to monitor parameters of the colliding beams such as the energy spectrum and polarization. The detector and beamline components must be protected against errant beams. After collision, the beams must also be transported to the beam dumps safely and with acceptable losses. An international team is actively working on the design of the ILC Beam Delivery System in close collaboration. Details of the design, recent progress and remaining challenges will be summarized in this paper.

  1. Post LHC8 SUSY benchmark points for ILC physics

    Energy Technology Data Exchange (ETDEWEB)

    Baer, Howard [Oklahoma Univ., Norman, OK (United States); List, Jenny [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2013-07-15

    We re-evaluate prospects for supersymmetry at the proposed International Linear e{sup +}e{sup -} Collider (ILC) in light of the first two years of serious data taking at LHC: LHC7 with {proportional_to}5 fb{sup -1} of pp collisions at {radical}(s)=7 TeV and LHC8 with {proportional_to}20 fb{sup -1} at {radical}(s)=8 TeV. Strong new limits from LHC8 SUSY searches, along with the discovery of a Higgs boson with m{sub h}{approx_equal}125 GeV, suggest a paradigm shift from previously popular models to ones with new and compelling signatures. After a review of the current status of supersymmetry, we present a variety of new ILC benchmark models, including: natural SUSY, radiatively-driven natural SUSY (RNS), NUHM2 with low m{sub A}, a focus point case from mSUGRA/CMSSM, non-universal gaugino mass (NUGM) model, {tau}-coannihilation, Kallosh-Linde/spread SUSY model, mixed gauge-gravity mediation, normal scalar mass hierarchy (NMH), and one example with the recently discovered Higgs boson being the heavy CP-even state H. While all these models at present elude the latest LHC8 limits, they do offer intriguing case study possibilities for ILC operating at {radical}(s){approx_equal} 0.25-1 TeV. The benchmark points also present a view of the widely diverse SUSY phenomena which might still be expected in the post LHC8 era at both LHC and ILC.

  2. Longitudinal Beam Diagnostics for the ILC Injectors and Bunch Compressors

    Energy Technology Data Exchange (ETDEWEB)

    Piot, Philippe [Northern Illinois U.; Bracke, Adam [Northern Illinois U.; Demir, Veysel [Northern Illinois U.; Maxwell, Timothy [Fermilab; Rihaoui, Marwan [Argonne; Jing, Chunguang [Euclid Techlabs, Solon; Power, John [Argonne

    2010-12-01

    We present a diagnostics suite and analyze techniques for setting up the longitudinal beam dynamics in ILC e⁻ injectors and e⁺ and e⁻ bunch compressors. Techniques to measure the first order moments and recover the first order longitudinal transfer map of the injector's intricate bunching scheme are presented. Coherent transition radiation diagnostics needed to measure and monitor the bunch length downstream of the ~5 GeV bunch compressor are investigated using a vector diffraction model.

  3. A quartz Cherenkov detector for polarimetry at the ILC

    Energy Technology Data Exchange (ETDEWEB)

    Vauth, Annika

    2014-09-15

    At the proposed International Linear Collider (ILC), the use of polarised electron and positron beams is a key ingredient of the physics program. A measurement of the polarisation with a yet unprecedented precision of {sup δP}/{sub P}=0.25% is required. To achieve this, Compton polarimeter measurements in front of and behind the collision point are foreseen. In this thesis, a novel concept for a detector for ILC polarimetry is introduced to eliminate one of the dominating systematics limiting the previous best measurement of beam polarisation: a detector using quartz as Cherenkov medium could increase the tolerance against non-linear photodetector responses. The high refractive index of quartz results in a higher Cherenkov light yield compared to conventional Cherenkov gases. This could allow single-peak resolution in the Cherenkov photon spectra produced by the Compton electrons at the polarimeters. The detailed simulation studies presented in this work imply that such single-peak resolution is possible. Considerations for the choice of a suitable detector geometry are discussed. A four-channel prototype has been constructed and successfully operated in a first testbeam campaign at the DESY testbeam, confirming simulation predictions. Although further studies have to be considered to quantify all aspects of the detector response, the findings of the analysis of the data from the first testbeam are promising with regards to reaching the desired light yield. In the final part of this thesis, the application of a detector concept allowing single-peak resolution to the polarisation measurement at the ILC is examined. Two of the main sources of systematic uncertainties on the polarimeter measurements are detector non-linearities and misalignments. The performance of the suggested quartz detector concept in Monte Carlo studies promises a control of these systematics which meets the precision requirements for ILC polarimetry.

  4. A Study of Thermocurrent Induced Magnetic Fields in ILC Cavities

    Energy Technology Data Exchange (ETDEWEB)

    Crawford, Anthony C. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Cooley, Victoria [Univ. of Wisconsin, Madison, WI (United States)

    2014-03-31

    The case of axisymmetric ILC-type cavities with titanium helium vessels is investigated. A first-order estimate for magnetic field within the SRF current layer is presented. The induced magnetic field is found to be not more than 1.4x10-8 Tesla = 0.14 milligauss for the case of axial symmetry. Magnetic fields due to symmetry breaking effects are discussed.

  5. A Study of Thermocurrent Induced Magnetic Fields in ILC Cavities

    Energy Technology Data Exchange (ETDEWEB)

    Crawford, Anthony C. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Cooley, Victoria [Univ. of Wisconsin, Madison, WI (United States)

    2014-03-31

    The case of axisymmetric ILC type cavities with titanium helium vessels is investigated. A first order estimate for magnetic field within the SRF current layer is presented. The induced magnetic field is found to be not more than 1.4x10-8 Tesla = 0.14 milligauss for the case of axial symmetry. Magnetic fields due to symmetry breaking effects are discussed.

  6. Phase cross-correlation of the WMAP ILC map and foregrounds

    CERN Document Server

    Naselsky, P D; Verkhodanov, O V

    2003-01-01

    We present a circular cross-correlation tests for the phases of the Internal Linear Combination Map (ILC) and {\\it WMAP}'s foregrounds for all K--W frequency bands at the range of multipoles $\\ell\\le 50$. We have found significant deviations from the expected Poissonian statistics for the ILC and the foregrounds phases. Our analysis shows that the low multipole range of the ILC power spectrum contains some of the foregrounds residues.

  7. Theoretical investigation on the electronic structure,elastic properties, and intrinsic hardness of Si2N2O

    Institute of Scientific and Technical Information of China (English)

    Ding Ying-Chun; Chen Min; Gao Xiu-Ying; Jiang Meng-Heng

    2012-01-01

    According to the density functional theory we systematically study the electronic structure,the mechanical properties and the intrinsic hardness of Si2N2O polymorphs using the first-principles method.The elastic constants of four Si2N2O structures are obtained using the stress-strain method.The mechanical moduli (bulk modulus,Young's modulus,and shear modulus) are evaluated using the Voigt-Reuss-Hill approach.It is found that the tetragonal Si2N2O exhibits a larger mechanical modulus than the other phases.Some empirical methods are used to calculate the Vickers hardnesses of the Si2N2O structures.We further estimate the Vickers hardnesses of the four Si2N2O crystal structures,suggesting all Si2N2O phases are not the superhard compounds.The results imply that the tetragonal Si2N2O is the hardest phase.The hardness of tetragonal Si2N2O is 31.52 GPa which is close to values of β-Si3N4 and γ-Si3N4.

  8. Intrinsic material property differences in bone tissue from patients suffering low-trauma osteoporotic fractures, compared to matched non-fracturing women.

    Science.gov (United States)

    Vennin, S; Desyatova, A; Turner, J A; Watson, P A; Lappe, J M; Recker, R R; Akhter, M P

    2017-04-01

    Osteoporotic (low-trauma) fractures are a significant public health problem. Over 50% of women over 50yrs. of age will suffer an osteoporotic fracture in their remaining lifetimes. While current therapies reduce skeletal fracture risk by maintaining or increasing bone density, additional information is needed that includes the intrinsic material strength properties of bone tissue to help develop better treatments, since measurements of bone density account for no more than ~50% of fracture risk. The hypothesis tested here is that postmenopausal women who have sustained osteoporotic fractures have reduced bone quality, as indicated with measures of intrinsic material properties compared to those who have not fractured. Transiliac biopsies (N=120) were collected from fracturing (N=60, Cases) and non-fracturing postmenopausal women (N=60, age- and BMD-matched Controls) to measure intrinsic material properties using the nano-indentation technique. Each biopsy specimen was embedded in epoxy resin and then ground, polished and used for the nano-indentation testing. After calibration, multiple indentations were made using quasi-static (hardness, modulus) and dynamic (storage and loss moduli) testing protocols. Multiple indentations allowed the median and variance to be computed for each type of measurement for each specimen. Cases were found to have significantly lower median values for cortical hardness and indentation modulus. In addition, cases showed significantly less within-specimen variability in cortical modulus, cortical hardness, cortical storage modulus and trabecular hardness, and more within-specimen variability in trabecular loss modulus. Multivariate modeling indicated the presence of significant independent mechanical effects of cortical loss modulus, along with variability of cortical storage modulus, cortical loss modulus, and trabecular hardness. These results suggest mechanical heterogeneity of bone tissue may contribute to fracture resistance

  9. INTRINSIC FACTORS AND FIRM FINANCIAL ANALYSIS WITH TRIPPLE BOTTOM LINES AS INTERVENING VARIABLE AGAINST FIRM VALUE Empirical Studies on Property and Real Estate Companies Year 2010-2013

    Directory of Open Access Journals (Sweden)

    Mia Andika Sari

    2016-09-01

    Full Text Available This research conducted to examine the influence of intrinsic factors which being peroxided with Capital Structure, Firm Size, Firm Age and Financial factors that being peroxided with liquidity, profitability also with another activities using triple bottom lines as Intervening Variable against Firm Value of Property Industries. The data that being used in this study were obtained from published financial statements during the period 2010 to 2013, as well as annual reports that can be accessed through the IDX website. Data analysis technique used in this study is a regression with panel data and path analysis. The results of this research showed that intrinsic factors and financial variables have a significant influence on the firm value, as well as intrinsic factors and financial variables have a significant influence on the triple bottom lines. From the results of path analysis demonstrated that the indirect effect using the triple bottom lines as a intervening variable was greater than the direct effect.

  10. Tuning THz emission properties of Bi2Sr2CaCu2O8+δ intrinsic Josephson junction stacks by charge carrier injection

    Science.gov (United States)

    Kizilaslan, O.; Rudau, F.; Wieland, R.; Hampp, J. S.; Zhou, X. J.; Ji, M.; Kiselev, O.; Kinev, N.; Huang, Y.; Hao, L. Y.; Ishii, A.; Aksan, M. A.; Hatano, T.; Koshelets, V. P.; Wu, P. H.; Wang, H. B.; Koelle, D.; Kleiner, R.

    2017-03-01

    We report on doping and undoping experiments of terahertz (THz) emitting intrinsic Josephson junction stacks, where the change in charge carrier concentration is achieved by heavy current injection. The experiments were performed on stand-alone structures fabricated from a Bi2Sr2CaCu2O{}8+δ single crystal near optimal doping. The stacks contained about 930 intrinsic Josephson junctions. On purpose, the doping and undoping experiments were performed over only a modest range of charge carrier concentrations, changing the critical temperature of the stack by less than 1 K. We show that both undoping and doping is feasible also for the large intrinsic Josephson junction stacks used for THz generation. Even moderate changes in doping introduce large changes in the THz emission properties of the stacks. The highest emission power was achieved after doping a pristine sample.

  11. Refractoriness in sustained visuo-manual control: is the refractory duration intrinsic or does it depend on external system properties?

    Science.gov (United States)

    van de Kamp, Cornelis; Gawthrop, Peter J; Gollee, Henrik; Loram, Ian D

    2013-01-01

    Researchers have previously adopted the double stimulus paradigm to study refractoriness in human neuromotor control. Currently, refractoriness, such as the Psychological Refractory Period (PRP) has only been quantified in discrete movement conditions. Whether refractoriness and the associated serial ballistic hypothesis generalises to sustained control tasks has remained open for more than sixty years. Recently, a method of analysis has been presented that quantifies refractoriness in sustained control tasks and discriminates intermittent (serial ballistic) from continuous control. Following our recent demonstration that continuous control of an unstable second order system (i.e. balancing a 'virtual' inverted pendulum through a joystick interface) is unnecessary, we ask whether refractoriness of substantial duration (~200 ms) is evident in sustained visual-manual control of external systems. We ask whether the refractory duration (i) is physiologically intrinsic, (ii) depends upon system properties like the order (0, 1(st), and 2(nd)) or stability, (iii) depends upon target jump direction (reversal, same direction). Thirteen participants used discrete movements (zero order system) as well as more sustained control activity (1(st) and 2(nd) order systems) to track unpredictable step-sequence targets. Results show a substantial refractory duration that depends upon system order (250, 350 and 550 ms for 0, 1(st) and 2(nd) order respectively, n=13, p<0.05), but not stability. In sustained control refractoriness was only found when the target reverses direction. In the presence of time varying actuators, systems and constraints, we propose that central refractoriness is an appropriate control mechanism for accommodating online optimization delays within the neural circuitry including the more variable processing times of higher order (complex) input-output relations.

  12. Refractoriness in sustained visuo-manual control: is the refractory duration intrinsic or does it depend on external system properties?

    Directory of Open Access Journals (Sweden)

    Cornelis van de Kamp

    Full Text Available Researchers have previously adopted the double stimulus paradigm to study refractoriness in human neuromotor control. Currently, refractoriness, such as the Psychological Refractory Period (PRP has only been quantified in discrete movement conditions. Whether refractoriness and the associated serial ballistic hypothesis generalises to sustained control tasks has remained open for more than sixty years. Recently, a method of analysis has been presented that quantifies refractoriness in sustained control tasks and discriminates intermittent (serial ballistic from continuous control. Following our recent demonstration that continuous control of an unstable second order system (i.e. balancing a 'virtual' inverted pendulum through a joystick interface is unnecessary, we ask whether refractoriness of substantial duration (~200 ms is evident in sustained visual-manual control of external systems. We ask whether the refractory duration (i is physiologically intrinsic, (ii depends upon system properties like the order (0, 1(st, and 2(nd or stability, (iii depends upon target jump direction (reversal, same direction. Thirteen participants used discrete movements (zero order system as well as more sustained control activity (1(st and 2(nd order systems to track unpredictable step-sequence targets. Results show a substantial refractory duration that depends upon system order (250, 350 and 550 ms for 0, 1(st and 2(nd order respectively, n=13, p<0.05, but not stability. In sustained control refractoriness was only found when the target reverses direction. In the presence of time varying actuators, systems and constraints, we propose that central refractoriness is an appropriate control mechanism for accommodating online optimization delays within the neural circuitry including the more variable processing times of higher order (complex input-output relations.

  13. Low concentrations of the solvent dimethyl sulphoxide alter intrinsic excitability properties of cortical and hippocampal pyramidal cells.

    Directory of Open Access Journals (Sweden)

    Francesco Tamagnini

    Full Text Available Dimethylsulfoxide (DMSO is a widely used solvent in biology. It has many applications perhaps the most common of which is in aiding the preparation of drug solutions from hydrophobic chemical entities. Recent studies have suggested that this molecule may be able to induce apoptosis in neural tissues urging caution regarding its introduction into humans, for example as part of stem cell transplants. Here we have used in vitro electrophysiological methods applied to murine brain slices to examine whether a few hours treatment with 0.05% DMSO (a concentration regarded by many as innocuous alters intrinsic excitability properties of neurones. We investigated pyramidal neurones in two distinct brain regions, namely area CA1 of the hippocampus and layer 2 of perirhinal cortex. In the former there was no effect on resting potential but input resistance was decreased by DMSO pre-treatment. In line with this action potential count for any level of depolarizing current stimulus was reduced by ∼25% following DMSO treatment. Ih-mediated "sag" was also increased in CA1 pyramids and action potential waveform analysis demonstrated that DMSO treatment moved action potential threshold towards resting potential. In perirhinal cortex a decreased action potential output for various depolarizing current stimuli was also seen. In these cells action potential threshold was unaltered by DMSO but a significant increase in action potential width was apparent. These data indicate that pre-treatment with this widely employed solvent can elicit multifaceted neurophysiological changes in mammalian neurones at concentrations below those frequently encountered in the published literature.

  14. Compaction and binding properties of the intrinsically disordered C-terminal domain of Henipavirus nucleoprotein as unveiled by deletion studies.

    Science.gov (United States)

    Blocquel, David; Habchi, Johnny; Gruet, Antoine; Blangy, Stéphanie; Longhi, Sonia

    2012-01-01

    Henipaviruses are recently emerged severe human pathogens within the Paramyxoviridae family. Their genome is encapsidated by the nucleoprotein (N) within a helical nucleocapsid that recruits the polymerase complex via the phosphoprotein (P). We have previously shown that in Henipaviruses the N protein possesses an intrinsically disordered C-terminal domain, N(TAIL), which undergoes α-helical induced folding in the presence of the C-terminal domain (P(XD)) of the P protein. Using computational approaches, we previously identified within N(TAIL) four putative molecular recognition elements (MoREs) with different structural propensities, and proposed a structural model for the N(TAIL)-P(XD) complex where the MoRE encompassing residues 473-493 adopt an α-helical conformation at the P(XD) surface. In this work, for each N(TAIL) protein, we designed four deletion constructs bearing different combinations of the predicted MoREs. Following purification of the N(TAIL) truncated proteins from the soluble fraction of E. coli, we characterized them in terms of their conformational, spectroscopic and binding properties. These studies provided direct experimental evidence for the structural state of the four predicted MoREs, and showed that two of them have clear α-helical propensities, with the one spanning residues 473-493 being strictly required for binding to P(XD). We also showed that Henipavirus N(TAIL) and P(XD) form heterologous complexes, indicating that the P(XD) binding regions are functionally interchangeable between the two viruses. By combining spectroscopic and conformational analyses, we showed that the content in regular secondary structure is not a major determinant of protein compaction.

  15. Adaptive ILC algorithms of nonlinear continuous systems with non-parametric uncertainties for non-repetitive trajectory tracking

    Science.gov (United States)

    Li, Xiao-Dong; Lv, Mang-Mang; Ho, John K. L.

    2016-07-01

    In this article, two adaptive iterative learning control (ILC) algorithms are presented for nonlinear continuous systems with non-parametric uncertainties. Unlike general ILC techniques, the proposed adaptive ILC algorithms allow that both the initial error at each iteration and the reference trajectory are iteration-varying in the ILC process, and can achieve non-repetitive trajectory tracking beyond a small initial time interval. Compared to the neural network or fuzzy system-based adaptive ILC schemes and the classical ILC methods, in which the number of iterative variables is generally larger than or equal to the number of control inputs, the first adaptive ILC algorithm proposed in this paper uses just two iterative variables, while the second even uses a single iterative variable provided that some bound information on system dynamics is known. As a result, the memory space in real-time ILC implementations is greatly reduced.

  16. Report of the Fermilab ILC Citizens' Task Force

    Energy Technology Data Exchange (ETDEWEB)

    None

    2008-06-01

    Fermi National Accelerator Laboratory convened the ILC Citizens' Task Force to provide guidance and advice to the laboratory to ensure that community concerns and ideas are included in all public aspects of planning and design for a proposed future accelerator, the International Linear Collider. In this report, the members of the Task Force describe the process they used to gather and analyze information on all aspects of the proposed accelerator and its potential location at Fermilab in northern Illinois. They present the conclusions and recommendations they reached as a result of the learning process and their subsequent discussions and deliberations. While the Task Force was charged to provide guidance on the ILC, it became clear during the process that the high cost of the proposed accelerator made a near-term start for the project at Fermilab unlikely. Nevertheless, based on a year of extensive learning and dialogue, the Task Force developed a series of recommendations for Fermilab to consider as the laboratory develops all successor projects to the Tevatron. The Task Force recognizes that bringing a next-generation particle physics project to Fermilab will require both a large international effort and the support of the local community. While the Task Force developed its recommendations in response to the parameters of a future ILC, the principles they set forth apply directly to any large project that may be conceived at Fermilab, or at other laboratories, in the future. With this report, the Task Force fulfills its task of guiding Fermilab from the perspective of the local community on how to move forward with a large-scale project while building positive relationships with surrounding communities. The report summarizes the benefits, concerns and potential impacts of bringing a large-scale scientific project to northern Illinois.

  17. Beam-induced backgrounds in detectors at the ILC

    Energy Technology Data Exchange (ETDEWEB)

    Vogel, Adrian

    2008-11-15

    There is general consensus in the high-energy physics community that the next particle collider to be built should be a linear electron-positron accelerator. Such a machine, colliding point-like particles with a well-defined initial state, would be an ideal complement to the Large Hadron Collider (LHC) and would allow high-precision measurements of the new physics phenomena that are likely to be discovered at the TeV energy scale. The most advanced project in that context is the International Linear Collider (ILC), aiming for a centre-of-mass energy of 500 GeV and a luminosity of 2 x 10{sup 34} cm{sup -2}s{sup -1} in its first stage. One of the detector concepts that are currently being developed and studied is the so-called International Large Detector (ILD). A prime feature of the ILD concept is the usage of a Time Projection Chamber (TPC) as the main tracker, which allows to reach the required momentum resolution, but which also has excellent particle identification capabilities and a highly robust and efficient tracking. The beam-beam interaction of the strongly focused particle bunches at the ILC will produce beamstrahlung photons, which can in turn scatter to electron-positron pairs. These pairs are a major source of detector backgrounds. This thesis explains the methods to study the effects of beam-induced electron-positron pair backgrounds with Mokka, a full detector simulation for the ILC that is based on Geant4, and it presents the simulation results for different detector configurations and various small modifications. The main focus of the simulations and their analysis is on the vertex detector and the TPC, but results for the inner silicon trackers and the hadronic calorimeters are shown as well. (orig.)

  18. Bunching for Shorter Damping Rings for the ILC

    CERN Document Server

    Neuffer, David V

    2005-01-01

    A variant rearrangement of the bunch trains for the ILC that enables much shorter damping rings is presented. In a particular example the ~2280 bunches are regrouped into ~450 subtrains of five adjacent bunches. These subtrains are extracted from the damping rings at ~2.2 ms intervals, obtaining the 1ms macrobunch length of the baseline TESLA collider scenario. If the baseline damping rf frequency is 325 MHz and the kicker rise and fall times are ~20 ns, a ring circumference of ~4.5km is required. Variations of the scheme could easily reduce the circumference to ~3km, and faster kickers could reduce it even further.

  19. Polarized positrons for the ILC - update on simulations

    CERN Document Server

    Staufenbiel, F

    2012-01-01

    To achieve the extremely high luminosity for colliding electron-positron beams at the future International Linear Collider (ILC) an undulator-based source with about 230 meters helical undulator and a thin titanium-alloy target rim rotated with tangential velocity of about 100 meters per second are foreseen. The very high density of heat deposited in the target has to be analyzed carefully. The energy deposited by the photon beam in the target has been calculated in FLUKA. The resulting stress in the target material after one bunch train has been simulated in ANSYS.

  20. DESIGN OF ILC EXTRACTION LINE FOR 20 MRAD CROSSING ANGLE

    Energy Technology Data Exchange (ETDEWEB)

    Nosochkov, Y.; Moffeit, K.; Seryi, A.; Woods, M.; /SLAC; Arnold, R.; /Massachusetts U., Amherst; Oliver, W.; /Tufts U.; Parker, B.; /Brookhaven; Torrence, E.; /Oregon U.

    2005-05-16

    One of the two ILC Interaction Regions will have a large horizontal crossing angle which would allow to extract the spent beams in a separate beam line. In this paper, the extraction line design for 20 mrad crossing angle is presented. This beam line transports the primary e{sup +}/e{sup -} and beamstrahlung photon beams from the IP to a common dump, and includes diagnostic section for energy and polarization measurements. The optics is designed for a large energy acceptance to minimize losses in the low energy tail of the disrupted beam. The extraction optics, diagnostic instrumentation and particle tracking simulations are described.

  1. The Higgs sector of the NMFV MSSM at the ILC

    CERN Document Server

    Arana-Catania, M; Herrero, M J; Penaranda, S

    2012-01-01

    We calculate the one-loop corrections to the Higgs boson masses within the context of the MSSM with Non-Minimal Flavor Violation in the squark sector. We take into account all the relevant restrictions from BR(B -> X_s gamma), BR(B_s -> mu^+ mu^-) and \\Delta M_{B_s}. We find sizable corrections to the lightest Higgs boson mass that are considerably larger than the expected ILC precision for acceptable values of the mixing parameters deltas. We find delta^{LR}_{ct} and delta^{RL}_{ct} specially relevant, mainly at low tan beta.

  2. INTRINSIC FACTORS AND FIRM FINANCIAL ANALYSIS WITH TRIPPLE BOTTOM LINES AS INTERVENING VARIABLE AGAINST FIRM VALUE Empirical Studies on Property and Real Estate Companies Year 2010-2013

    OpenAIRE

    Sari, Mia Andika; Wiralaga, Harya Kuncara; Warokka, Ari

    2016-01-01

    This research conducted to examine the influence of intrinsic factors which being proxied with Capital Structure, Firm Size, Firm Age and Financial factors that being proxied with liquidity, profitability also with another activities using tripple bottom lines as Intervening Variable against Firm Value of Property Industries. The data that being used in this study were obtained from published financial statements during the period 2010 to 2013, as well as annual reports that can be accessed t...

  3. Variability in State-Dependent Plasticity of Intrinsic Properties during Cell-Autonomous Self-Regulation of Calcium Homeostasis in Hippocampal Model Neurons1,2,3

    Science.gov (United States)

    Srikanth, Sunandha

    2015-01-01

    Abstract How do neurons reconcile the maintenance of calcium homeostasis with perpetual switches in patterns of afferent activity? Here, we assessed state-dependent evolution of calcium homeostasis in a population of hippocampal pyramidal neuron models, through an adaptation of a recent study on stomatogastric ganglion neurons. Calcium homeostasis was set to emerge through cell-autonomous updates to 12 ionic conductances, responding to different types of synaptically driven afferent activity. We first assessed the impact of theta-frequency inputs on the evolution of ionic conductances toward maintenance of calcium homeostasis. Although calcium homeostasis emerged efficaciously across all models in the population, disparate changes in ionic conductances that mediated this emergence resulted in variable plasticity to several intrinsic properties, also manifesting as significant differences in firing responses across models. Assessing the sensitivity of this form of plasticity, we noted that intrinsic neuronal properties and the firing response were sensitive to the target calcium concentration and to the strength and frequency of afferent activity. Next, we studied the evolution of calcium homeostasis when afferent activity was switched, in different temporal sequences, between two behaviorally distinct types of activity: theta-frequency inputs and sharp-wave ripples riding on largely silent periods. We found that the conductance values, intrinsic properties, and firing response of neurons exhibited differential robustness to an intervening switch in the type of afferent activity. These results unveil critical dissociations between different forms of homeostasis, and call for a systematic evaluation of the impact of state-dependent switches in afferent activity on neuronal intrinsic properties during neural coding and homeostasis. PMID:26464994

  4. Top physics at CLIC and ILC

    CERN Document Server

    Zarnecki, Aleksander Filip

    2016-01-01

    Measurements of top quark production at $e^+e^-$ colliders can provide a leap in precision in our knowledge of top quark properties and open a new window on physics beyond the Standard Model. In this contribution the top quark physics prospects of linear colliders is reviewed. Progress in detailed full-simulation studies is reported for the highlights of the program. We present the prospects for a measurement of the top quark mass and width in a scan of the beam energy through the pair production threshold, and discuss new studies of alternative measurements in continuum production, which are also capable of a precise determination of the mass in a rigorously defined mass scheme. A precision of 50 MeV on the $\\overline{MS}$ mass is expected when taking into account the dominant systematic uncertainties. Another key measurement is the study of the top quark couplings to electroweak gauge bosons, where form factors can be determined to 1% precision, an order of magnitude better than those from the full LHC prog...

  5. Top physics at CLIC and ILC

    CERN Document Server

    Zarnecki, Aleksander

    2016-01-01

    Measurements of top quark production at $e^+e^-$ colliders can provide a leap in precision in our knowledge of top quark properties and open a new window on physics beyond the Standard Model. In this contribution the top quark physics prospects of linear colliders is reviewed. Progress in detailed full-simulation studies is reported for the highlights of the program. We present the prospects for a measurement of the top quark mass and width in a scan of the beam energy through the pair production threshold, and discuss new studies of alternative measurements in continuum production, which are also capable of a precise determination of the mass in a rigorously defined mass scheme. A precision of 50 MeV on the $\\overline{MS}$ mass is expected when taking into account the dominant systematic uncertainties. Another key measurement is the study of the top quark couplings to electroweak gauge bosons, where form factors can be determined to 1% precision, an order of magnitude better than those from the full LHC prog...

  6. Full simulation of the beam-related backgrounds at the ILC

    Energy Technology Data Exchange (ETDEWEB)

    Schuetz, Anne [DESY (Germany); KIT (Germany)

    2016-07-01

    The ILC has been proposed as the next machine at the energy frontier and a Technical Design Report was presented in 2012. As part of the site-specific studies to prepare the hosting of the ILC in Japan, the final focus region of the ILC had to be adapted. In this contribution, updated results for the beam-related background as well as new results for the backgrounds originating from the beam dump are presented. The beam-related backgrounds are simulated using GuineaPig and are then propagated through the full simulation of the SiD detector. The impact of various modifications in the final-focus region on the detector occupancies are then evaluated. For the neutron background from the beam dump, the FLUKA simulation suite is used, which is well established for dosimetry and shielding studies. With this program, the effect of the neutrons from the ILC beam dumps on the ILC detectors are studied.

  7. Physics Interplay of the LHC and the ILC

    Energy Technology Data Exchange (ETDEWEB)

    Weiglein, G.

    2004-12-17

    Physics at the Large Hadron Collider (LHC) and the International e{sup +}e{sup -} Linear Collider (ILC)will be complementary in many respects, as has been demonstrated at previous generations of hadron and lepton colliders. This report addresses the possible interplay between the LHC and ILC in testing the Standard Model and in discovering and determining the origin of new physics. Mutual benefits for the physics programme at both machines can occur both at the level of a combined interpretation of Hadron Collider and Linear Collider data and at the level of combined analyses of the data, where results obtained at one machine can directly influence the way analyses are carried out at the other machine. Topics under study comprise the physics of weak and strong electroweak symmetry breaking, supersymmetric models, new gauge theories, models with extra dimensions, and electroweak and QCD precision physics. The status of the work that has been carried out within the LHC/LC Study Group so far is summarized in this report. Possible topics for future studies are outlined.

  8. In search of new phenomena using polarization. HERA and ILC

    Energy Technology Data Exchange (ETDEWEB)

    Helebrant, Christian

    2009-12-15

    The longitudinal polarization of leptons can be used as an important tool in the search for new phenomena at particle colliders. In the first part of this thesis a search for first generation leptoquarks at the H1 experiment is presented. During the HERA-2 runperiod polarized lepton beams were used. The analysis presented herein utilizes this fact in order to enhance the sensitivity to these chirally coupling leptoquarks. Since no evidence for their existence is found, exclusion limits depending on the mass and Yukawa coupling are calculated. This analysis can exclude leptoquarks coupling at electromagnetic strength up to masses of 280-300 GeV, depending on the leptoquark quantum numbers. A new domain of physics is expected to be open to the planned electron positron linear collider ILC, where polarized lepton beams will play an important role. In order to fully exploit its physics potential, the polarization will have to be measured with an as yet unequaled precision of 0.25%, which is expected to be limited by systematic effects, like the nonlinearity of the photodetectors employed. In the second part of this thesis several methods are tested with respect to their capability to resolve photodetector nonlinearities at the permille level, and checked for their long term stability. With some of the methods presented herein it will be possible to measure and correct photodetector nonlinearities at a running ILC experiment with the accuracy required in order to achieve the aimed precision of the polarization measurement. (orig.)

  9. Considerations for a QD0 with Hybrid Technology in ILC

    CERN Document Server

    Modena, M; Garcia, H; Gatignon, L; Tomas, R

    2014-01-01

    The baseline design of the QD0 magnet for ILC, the International Linear Collider, is a very compact superconducting quadrupole (coil-dominated magnet). A prototype of this quadrupole is under construction at Brookhaven National Laboratory (USA). In CLIC, the Compact Linear Collider under study at CERN, we are studying a different conceptual solution for the QD0. This is due to two main reasons: all the magnets of the Beam Delivery System will need to be stabilized in the nano-meter range and extremely tight alignment tolerances are required. The proposed solution, now baseline for CLIC, is a room temperature hybrid quadrupole based on resistive coils and permanent magnet blocks (iron-dominated magnet). In this paper we present a conceptual design for a hybrid solution studied and adapted also to the ILC project. A super-ferric solution (superconducting coils with warm iron poles) is proposed to make the cross section compatible with the layout of the experiments. This design matches the compactness requiremen...

  10. Physics Interplay of the LHC and the ILC

    CERN Document Server

    Weiglein, Georg; Boos, E; de Roeck, A; Desch, Klaus; Gianotti, F; Godbole, Rohini M; Gunion, J F; Haber, Howard E; Heinemeyer, S; Hewett, J L; Kawagoe, K; Mönig, K; Nojiri, M M; Polesello, G; Richard, F; Riemann, S; Stirling, W J; Akeroyd, A G; Allanach, Benjamin C; Asner, David M; Asztalos, S; Baer, H; Battaglia, Marco; Baur, U; Bechtle, P; Bélanger, G; Belyaev, A; Berger, E L; Binoth, T; Blair, G A; Boogert, S; Boudjema, F; Bourilkov, D; Buchmüller, Wilfried; Bunichev, V; Cerminara, G; Chiorboli, M; Davoudiasl, H; Dawson, S; De Curtis, S; Deppisch, F; Díaz, M A; Dittmar, M; Djouadi, A; Dominici, Daniele; Ellwanger, U; Feng, J L; Ginzburg, I F; Giolo-Nicollerat, Anne Sylvie; Gjelsten, B K; Godfrey, S; Grellscheid, D; Gronberg, J; Gross, E; Guasch, J; Hamaguchi, K; Han, T; Hisano, J; Hollik, W; Hugonie, C; Hurth, Tobias; Jiang, J; Juste, A; Kalinowski, Jan; Kilian, W; Kinnunen, R; Kraml, Sabine; Krawczyk, M; Krokhotine, A; Krupovnickas, T; Lafaye, R; Lehti, S; Logan, H E; Lytken, E; Martin, V; Martyn, H U; Miller, D J; Moretti, S; Moortgat, F; Moortgat-Pick, G; Mühlleitner, M M; Niezurawski, P; Nikitenko, A N; Orr, L H; Osland, P; Osorio, A F; Päs, H; Plehn, T; Porod, Werner; Pukhov, A E; Quevedo, Fernando; Rainwater, D L; Ratz, M; Redelbach, A; Reina, L; Rizzo, T; Rückl, R; Schreiber, H J

    2006-01-01

    Physics at the Large Hadron Collider (LHC) and the International e+e- Linear Collider (ILC) will be complementary in many respects, as has been demonstrated at previous generations of hadron and lepton colliders. This report addresses the possible interplay between the LHC and ILC in testing the Standard Model and in discovering and determining the origin of new physics. Mutual benefits for the physics programme at both machines can occur both at the level of a combined interpretation of Hadron Collider and Linear Collider data and at the level of combined analyses of the data, where results obtained at one machine can directly influence the way analyses are carried out at the other machine. Topics under study comprise the physics of weak and strong electroweak symmetry breaking, supersymmetric models, new gauge theories, models with extra dimensions, and electroweak and QCD precision physics. The status of the work that has been carried out within the LHC / LC Study Group so far is summarised in this report....

  11. First results with prototype ISIS devices for ILC vertex detector

    Energy Technology Data Exchange (ETDEWEB)

    Damerell, C., E-mail: c.damerell@rl.ac.u [RAL, Oxon OX11 0QX (United Kingdom); Zhang, Z. [RAL, Oxon OX11 0QX (United Kingdom); Gao, R.; John John, Jaya; Li, Y.; Nomerotski, A. [Oxford U (United Kingdom); Holland, A.; Seabroke, G. [Centre for Electronic Imaging, Open U (United Kingdom); Havranek, M. [Czech Technical University in Prague (Czech Republic); Stefanov, K. [Sentec Ltd, Cambridge (United Kingdom); Kar-Roy, A. [Jazz Semiconductors, California (United States); Bell, R.; Burt, D.; Pool, P. [e2V Technologies, Chelmsford (United Kingdom)

    2010-12-11

    The vertex detectors at the International Linear Collider (ILC) (there will be two of them, one for each of two general purpose detectors) will certainly be built with silicon pixel detectors, either monolithic or perhaps vertically integrated. However, beyond this general statement, there is a wide range of options supported by active R and D programmes all over the world. Pixel-based vertex detectors build on the experience at the SLAC large detector (SLD) operating at the SLAC linear collider (SLC), where a 307 Mpixel detector permitted the highest physics performance at LEP or SLC. For ILC, machine conditions demand much faster readout than at SLC, something like 20 time slices during the 1 ms bunch train. The approach of the image sensor with in-situ storage (ISIS) is unique in offering this capability while avoiding the undesirable requirement of 'pulsed power'. First results from a prototype device that approaches the pixel size of 20 {mu}m square, needed for physics, are reported. The dimensional challenge is met by using a 0.18 {mu}m imaging CMOS process, instead of a conventional CCD process.

  12. Hadron production in photon-photon processes at the ILC

    Energy Technology Data Exchange (ETDEWEB)

    Sasikumar, Kollassery Swathi [Deutsches Elektronen-Synchrotron (DESY), Notkestrasse 85, 22607 Hamburg (Germany); Universitaet Hamburg, Institut fuer Experimentalphysik, Luruper Chaussee 149, 22761 Hamburg (Germany); Berggren, Carl Mikael; List, Jenny [Deutsches Elektronen-Synchrotron (DESY), Notkestrasse 85, 22607 Hamburg (Germany)

    2016-07-01

    The International linear Collider (ILC) is a proposed e{sup +}e{sup -} collider, designed to operate at energies from 91 GeV upto about 500 GeV (with the possibility to upgrade to 1 TeV). The highly clean conditions provided by the ILC enables us to make high precision measurements e.g. of the Higgs boson and to search for new particles. In addition to the desired e{sup +}e{sup -} collisions, parasitic collisions of real and virtual photons radiated off the e{sup ±} beams occur at rates of a few γγ collisions per bunch crossing. The γγ centre of mass energies reach from few 100 MeV up to the full e{sup +}e{sup -} centre of mass energy. For all these energies, in particular the production of hadrons,needs to be modelled correctly in order to estimate the impact of these backgrounds which pile-up on each e{sup +}e{sup -} event. This contribution discusses the current simulations of γγ → hadron processes, evaluates their impact on the detector and introduces new methods to remove them from the interesting physics events.

  13. A DEPFET pixel system for the ILC vertex detector

    CERN Document Server

    Trimpl, M; Kohrs, R; Krüger, H; Lodomez, P; Reuen, L; Sandow, C; Toerne, E; Velthuis, J J; Wermes, N; Andricek, L; Moser, H G; Richter, R H; Lutz, Gerhard; Giesen, F; Fischer, P; Peric, I

    2006-01-01

    We have developed a prototype system for the ILC vertex detector based on DEPFET pixels. The system operates a 128x64 pixel matrix and uses two dedicated microchips, the SWITCHER II chip for matrix steering and the CURO II chip for readout. The system development has been driven by the final ILC requirements which above all demand a detector thinned to 50 micron and a row wise read out with line rates of 20MHz and more. The targeted noise performance for the DEPFET technology is in the range of ENC=100e-. The functionality of the system has been demonstrated using different radioactive sources in an energy range from 6keV to 60keV. In recent test beam experiments using 6GeV electrons, a signal-to-noise ratio of S/N~120 has been achieved with present sensors being 450 micron thick. For improved DEPFET systems using 50 micron thin sensors in future, a signal-to-noise of 40 is expected.

  14. Conversion efficiency and luminosity for gamma-proton colliders based on the LHC-CLIC or LHC-ILC QCD explorer scheme

    Energy Technology Data Exchange (ETDEWEB)

    Aksakal, H. [Department of Physics, Faculty of Science, Ankara University, 06100 Tandogan, Ankara (Turkey) and Department of Physics, Faculty of Art and Science, Nigde University, 51200 Nigde (Turkey)]. E-mail: aksakal@science.ankara.edu.tr; Ciftci, A.K. [Department of Physics, Faculty of Science, Ankara University, 06100 Tandogan, Ankara (Turkey); Nergiz, Z. [Department of Physics, Faculty of Science, Ankara University, 06100 Tandogan, Ankara (Turkey); Department of Physics, Faculty of Art and Science, Nigde University, 51200 Nigde (Turkey); Schulte, D. [CERN, 1211, Geneva 23 (Switzerland); Zimmermann, F. [CERN, 1211, Geneva 23 (Switzerland)

    2007-06-21

    Gamma-proton collisions allow unprecedented investigations of the low x and high Q{sup 2} regions in quantum chromodynamics. In this paper, we investigate the luminosity for ''ILC''xLHC(s{sub ep}=1.3TeV) and ''CLIC''xLHC(s{sub ep}=1.45TeV) based {gamma}p colliders. Also we determine the laser properties required for high conversion efficiency.

  15. Off-stoichiometric silver antimony telluride: An experimental study of transport properties with intrinsic and extrinsic doping

    Directory of Open Access Journals (Sweden)

    Michele D. Nielsen

    2015-05-01

    Full Text Available AgSbTe2 is a thermoelectric semiconductor with an intrinsically low thermal conductivity and a valence band structure that is favorable to obtaining a high thermoelectric figure of merit zT. It also has a very small energy gap Eg ∼ 7.6 ± 3 meV. As this gap is less than the thermal excitation energy at room temperature, near-intrinsic AgSbTe2 is a two carrier system having both holes (concentration p and electrons (n. Good thermoelectric performance requires heavy p-type doping (p > > n. This can be achieved with native defects or with extrinsic doping, e.g. with transition metal element. The use of defect doping is complicated by the fact that many of the ternary Ag-Sb-Te and pseudo-binary Sb2Te3-Ag2Te phase diagrams are contradictory. This paper determines the compositional region most favorable to creating a single phase material. Through a combination of intrinsic and extrinsic doping, values of zT > 1 are achieved, though not on single-phased material. Additionally, we show that thermal conductivity is not affected by defects, further demonstrating that the low lattice thermal conductivity of I-V-VI2 materials is due to an intrinsic mechanism, insensitive to changes in defect structure.

  16. Unveiling the intrinsic X-ray properties of broad absorption line quasars with a relatively unbiased sample

    Energy Technology Data Exchange (ETDEWEB)

    Morabito, Leah K.; Dai, Xinyu; Leighly, Karen M. [Homer L. Dodge Department of Physics and Astronomy, University of Oklahoma, Norman, OK 73019 (United States); Sivakoff, Gregory R. [Department of Physics, University of Alberta, CCIS 4-183 Edmonton, AB T6G 2E1 (Canada); Shankar, Francesco [School of Physics and Astronomy, University of Southampton, Southampton SO17 IBJ (United Kingdom)

    2014-05-01

    There is growing evidence of a higher intrinsic fraction of broad absorption line quasars (BALQSOs) than that obtained in optical surveys, on which most previous X-ray studies of BALQSOs have focused. Here we present Chandra observations of 18 BALQSOs at z ∼ 2, selected from a near-infrared (Two Micron All Sky Survey) sample, where the BALQSO fraction is likely to be close to the intrinsic fraction. We measure photon indices using the stacked spectra of the optically faint (i – K{sub s} ≥ 2.3 mag) and optically bright (i – K{sub s} < 2.3 mag) samples to be Γ ≅ 1.5-2.1. We constrain their intrinsic column density by modeling the X-ray fractional hardness ratio, finding a mean column density of 3.5 × 10{sup 22} cm{sup –2} assuming neutral absorption. We incorporate Sloan Digital Sky Survey optical measurements (rest frame UV) to study the broadband spectral index between the X-ray and UV bands, and compare this to a large sample of normal quasars. We estimate that the optically faint BALQSOs are X-ray weaker than the optically bright ones, and the entire sample of BALQSOs are intrinsically X-ray weak when compared to normal active galactic nuclei (AGNs). Correcting for magnification of X-ray emission via gravitational lensing by the central black hole viewed at large inclination angles makes these BALQSOs even more intrinsically X-ray weak. Finally, we estimate AGN kinetic feedback efficiencies of a few percent for an X-ray wind of 0.3c in high-ionization BALQSOs. Combined with energy carried by low-ionization BALQSOs and UV winds, the total kinetic energy in BALQSOs can be sufficient to provide AGN kinetic feedback required to explain the co-evolution between black holes and host galaxies.

  17. From neutrino physics to beam polarisation. A high precision story at the ILC

    Energy Technology Data Exchange (ETDEWEB)

    Vormwald, Benedikt

    2014-03-15

    In this thesis, we investigate the experimental prospects of studying a supersymmetric model with bilinearly broken R parity at the International Linear Collider. In this model, neutrinos mix with the supersymmetric neutralinos such that neutrino properties can be probed by examining neutralino decays, which incorporate usually a lepton and a W/Z boson. As a study case, we focus on the determination of the atmospheric neutrino mixing angle θ{sub 23}, which is accessible via the ratio of the neutralino branching ratios BR(χ{sup 0}{sub 1}→Wμ)/BR(χ{sup 0}{sub 1}→Wτ). A detailed simulation of the International Large Detector has been performed for all Standard Model backgrounds and for χ{sup 0}{sub 1}-pair production within a simplified model. The study is based on ILC beam parameters according to the Technical Design Report for a center-of-mass energy of √(s)=500 GeV. From muonic χ{sup 0}{sub 1} decays, we find that the χ{sup 0}{sub 1} mass can be reconstructed with an uncertainty of δ(m{sub χ{sup 0}{sub 1}})=(40(stat.)+35(syst.)) MeV for an integrated luminosity of ∫Ldt=500 fb{sup -1}. The ratio of branching ratios can be determined to a precision of δ(BR(χ{sup 0}{sub 1}→Wμ)/BR(χ{sup 0}{sub 1}→Wτ))=2.9%. Due to this, the atmospheric neutrino mixing angle can be deduced with a precision comparable to modern neutrino experiments. Thus, the ILC is capable to test whether bRPV SUSY is the mechanism of neutrino mass generation. As also shown in the bRPV SUSY study of this thesis, beam polarisation is an important parameter in physics analyses at the ILC. The beam polarisation is measured with two Compton polarimeters per electron/positron beam. In order to achieve the design goal of an envisaged precision of 0.25%, the detector nonlinearity of the used Cherenkov detectors has to be determined very precisely. Herein, the main source of nonlinearity is expected to originate from the involved photomultipliers. For this reason, a differential

  18. Effect of sputtering power on crystallinity, intrinsic defects, and optical and electrical properties of Al-doped ZnO transparent conducting thin films for optoelectronic devices

    Science.gov (United States)

    Hu, Yu Min; Li, Jung Yu; Chen, Nai Yun; Chen, Chih Yu; Han, Tai Chun; Yu, Chin Chung

    2017-02-01

    The crystallinity and intrinsic defects of transparent conducting oxide (TCO) films have a high impact on their optical and electrical properties and therefore on the performance of devices incorporating such films, including flat panel displays, electro-optical devices, and solar cells. The optical and electrical properties of TCO films can be modified by tailoring their deposition parameters, which makes proper understanding of these parameters crucial. Magnetron sputtering is the most adaptable method for preparing TCO films used in industrial applications. In this study, we investigate the direct and inter-property correlation effects of sputtering power (PW) on the crystallinity, intrinsic defects, and optical and electrical properties of Al-doped ZnO (AZO) TCO films. All of the films were preferentially c-axis-oriented with a wurtzite structure and had an average transmittance of over 80% in the visible wavelength region. Scanning electron microscopy images revealed significantly increased AZO film grain sizes for PW ≥ 150 W, which may lead to increased conductivity, carrier concentration, and optical band gaps but decreased carrier mobility and in-plane compressive stress in AZO films. Photoluminescence results showed that, with increasing PW, the near band edge emission gradually dominates the defect-related emissions in which zinc interstitial (Zni), oxygen vacancy (VO), and oxygen interstitial (Oi) are possibly responsible for emissions at 3.08, 2.8, and 2.0 eV, respectively. The presence of Zni- and Oi-related emissions at PW ≥ 150 W indicates a slight increase in the presence of Al atoms substituted at Zn sites (AlZn). The presence of Oi at PW ≥ 150 W was also confirmed by X-ray photoelectron spectroscopy results. These results clearly show that the crystallinity and intrinsic-defect type of AZO films, which dominate their optical and electrical properties, may be controlled by PW. This understanding may facilitate the development of TCO

  19. Structural properties of intrinsic and doped nc-Si:H films prepared by RFMS: Study as function of deposition time and substrate temperature

    Energy Technology Data Exchange (ETDEWEB)

    Belfedal, A.; Bouizem, Y.; Benlakehal, D.; Sib, J.D.; Kebab, A.; Chahed, L. [Laboratoire de Physique des Couches Minces et Materiaux pour l' Electronique Universite d' Oran (Algeria); Baghdad, R. [Laboratoire de Genie Physique, Universite Ibn Khaldoun, Tiaret (Algeria); Zellama, K. [Laboratoire de Physique de la Matiere Condensee, Faculte des Sciences, Universite de Picardie Jules Verne, Amiens (France)

    2010-04-15

    This study investigates the structural properties of the intrinsic and the (n or p) doped nc-Si:H samples deposited by RFMS technique during different deposition times (3 and 30 minutes) at low growth temperatures (room temperature and 100 C) under the same experimental conditions of the plasma leading to optimized films. Our results clearly show that the crystallization occurs in the doped films during the first times of the growth, while it is not yet initiated for the intrinsic films in the same plasma conditions. The crystallization is more important in the p doped samples, and is not achieved during the first times of the growth. The thick films are more crystallized even the low growth temperatures and contain low quantity of hydrogen than the thin ones. (copyright 2010 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  20. H∞ approach to monotonically convergent ILC for uncertain time-varying delay systems

    Science.gov (United States)

    Meng, Deyuan; Jia, Yingmin; Du, Junping

    2015-01-01

    This paper deals with iterative learning control (ILC) design for uncertain time-delay systems. Monotonic convergence of the resulting ILC process is studied, and a sufficient condition within an H∞-based framework is developed. It is shown that under this framework, delay-dependent conditions can be obtained in terms of linear matrix inequalities (LMIs), together with formulas for gain matrices design. A numerical example is provided to illustrate the effectiveness of the robust H∞-based approach to ILC designed via LMIs.

  1. Dark matter relic density from observations of supersymmetry at the ILC

    Energy Technology Data Exchange (ETDEWEB)

    Lehtinen, Suvi-Leena; List, Jenny; Berggren, Mikael [DESY, Hamburg (Germany)

    2016-07-01

    If supersymmetric particles were discovered at the International Linear Collider (ILC), would we be able to prove that the dark matter candidate discovered is the only dark matter particle? This was investigated using a scenario with a mostly bino lightest supersymmetric particle and a coannihilating stau. In this scenario, the ILC could find the sleptons and lighter gauginos, while the LHC could discover and measure parts of the coloured spectrum. We will demonstrate which measurements and precisions are needed to determine whether the observed dark matter candidate is the sole constituent of the dark matter relic density. The required precisions will be compared to the predicted precisions at the ILC.

  2. Radiation damage of the ILC positron source target

    Energy Technology Data Exchange (ETDEWEB)

    Ushakov, A.; Riemann, S.

    2007-11-15

    The radiation damage of the positron source target for the International Linear Collider (ILC) has been studied. The displacement damage in target material due to multi-MeV photons has been calculated by combining FLUKA simulations for secondary particle production, SPECTER data for neutron displacement cross-sections and the Lindhard model for estimations of displacement damage by ions. The radiation damage of a stationary Ti6Al4V target in units of displacements per atom (dpa) has been estimated for photons from an undulator with strength 0.92 and period 1.15 cm. The calculated damage is 7 dpa. Approximately 12.5% of displacement damage result from neutrons. (orig.)

  3. Improving Higgs coupling measurements through ZZ Fusion at the ILC

    CERN Document Server

    Han, Tao; Qian, Zhuoni; Sayre, Joshua

    2015-01-01

    We evaluate the $e^- e^+ \\to e^- e^+ +h $ process through the $ZZ$ fusion channel at the International Linear Collider (ILC) operating at $500$ GeV and $1$ TeV center of mass energies. We perform realistic simulations on the signal process and background processes. With judicious kinematic cuts, we find that the inclusive cross section can be measured to $2.9\\%$ after combining the $500$ GeV at $500 ~\\text{fb}^{-1}$ and $1$ TeV at $1~ \\text{ab}^{-1}$ runs. A multivariate log-likelihood analysis further improves the precision of the cross section measurement to $2.3\\%$. We discuss the overall improvement to model-independent Higgs width and coupling determinations and demonstrate the use of different channels in distinguishing new physics effects in Higgs physics. Our study demonstrates the importance of the $ZZ$ fusion channel to Higgs precision physics, which has often been neglected in the literature.

  4. Reconstruction of IP Beam Parameters at the ILC From Beamstrahlung

    Energy Technology Data Exchange (ETDEWEB)

    White, G.; /SLAC /Queen Mary, U. of London

    2005-07-11

    The luminosity performance of the ILC will be very sensitive to the parameters of the colliding bunches. Only some of these parameters can be measured using planned instrumentation. This analysis aims to access some of the colliding beam parameters not available by other means and to improve on the resolution of those that are. GUINEA-PIG is used to simulate the beam-beam interactions and produce beamstrahlung radiation (e+/e- pairs and photons). These are tracked to a simulation of the low-angle Beam Calorimeter and a photon detector and event shapes are produced. A Taylor map is produced to transform from the event shapes to the simulated beam parameters. This paper reports on the progress of this analysis, examining the usefulness of the proposed fitting technique.

  5. Radiation damage of the ILC positron source target

    Energy Technology Data Exchange (ETDEWEB)

    Ushakov, A.; Riemann, S.

    2007-11-15

    The radiation damage of the positron source target for the International Linear Collider (ILC) has been studied. The displacement damage in target material due to multi-MeV photons has been calculated by combining FLUKA simulations for secondary particle production, SPECTER data for neutron displacement cross-sections and the Lindhard model for estimations of displacement damage by ions. The radiation damage of a stationary Ti6Al4V target in units of displacements per atom (dpa) has been estimated for photons from an undulator with strength 0.92 and period 1.15 cm. The calculated damage is 7 dpa. Approximately 12.5% of displacement damage result from neutrons. (orig.)

  6. Compact Superconducting Final Focus Magnet Options for the ILC

    CERN Document Server

    Parker, Brett; Escallier, John; Harrison, Michael; He, Ping; Jain, Animesh K; Markiewicz, Thomas W; Marone, Andrew; Maruyama, Takashi; Nosochkov, Yuri; Seryi, Andrei; Wu, Kuo-Chen

    2005-01-01

    We present a compact superconducting final focus (FF) magnet system for the ILC based on recent BNL direct wind technology developments. Direct wind gives an integrated coil prestress solution for small transverse size coils. With beam crossing angles more than 15 mr, disrupted beam from the IP passes outside the coil while incoming beam is strongly focused. A superconducting FF magnet is adjustable to accommodate collision energy changes, i.e. energy scans and low energy calibration runs. A separate extraction line permits optimization of post IP beam diagnostics. Direct wind construction allows adding separate coils of arbitrary multipolarity (such as sextupole coils for local chromaticity correction). In our simplest coil geometry extracted beam sees significant fringe field. Since the fringe field affects the extracted beam, we also study advanced configurations that give either dramatic fringe field reduction (especially critical for gamma-gamma colliders) or useful quadrupole focusing on the outgoing be...

  7. ILC Extraction Line for 14 mrad Crossing Angle

    Energy Technology Data Exchange (ETDEWEB)

    Nosochkov, Y.; Markiewicz, T.; Maruyama, T.; Seryi, A.; /SLAC; Parker, B.; /Brookhaven

    2005-12-08

    The earlier studies of the ILC extraction line for 20 mrad and 2 mrad crossing angle options [1]-[5] showed that the 20 mrad design has an advantage of a simpler beamline and lower extraction beam loss because of the independent incoming and extraction optics. However, the large 20 mrad crossing angle requires the use of a crab cavity correction, increases synchrotron radiation emittance growth in the solenoid, and increases photon backscattering from the forward calorimeter of the detector. To reduce these effects, an attempt has been made to minimize the crossing angle while keeping the extraction and incoming lines separate. A new quadrupole scheme near the interaction point has been proposed which allows a reduction of the crossing angle to 14 mrad [6]. The optics design and results of tracking and background simulations for the 14 mrad extraction line are presented.

  8. Depolarization in the ILC Linac-to-Ring Positron Beamline

    CERN Document Server

    Riemann, Sabine

    2012-01-01

    To achieve the physics goals of future Linear Colliders, it is important that electron and positron beams are polarized. The positron source planned for the International Linear Collider (ILC) is based on a helical undulator system and can deliver a polarised beam with positron polarization of 60%. To ensure that no significant polarization is lost during the transport of the electron and positron beams from the source to the interaction region, spin tracking has to be included in all transport elements which can contribute to a loss of polarization. These are the positron source, the damping ring, the spin rotators, the main linac and the beam delivery system. In particular, the dynamics of the polarized positron beam is required to be investigated. The results of positron spin tracking and depolarization study at the Positron-Linac-To-Ring (PLTR) beamline are presented.

  9. Configuration Studies and Recommendations for the ILC DampingRings

    Energy Technology Data Exchange (ETDEWEB)

    Wolski, Andrzej; Gao, Jie; Guiducci, Susanna

    2006-02-04

    We describe the results of studies comparing differentoptions for the baseline configuration of the ILC damping rings. Theprincipal configuration decisions apply to the circumference, beamenergy, lattice type, and technology options for key components,including the injection/extraction kickers and the damping wigglers. Toarrive at our recommended configuration, we performed detailed studies ofa range of lattices representing a variety of different configurationoptions; these lattices are described in Chapter 2. The results of thevarious studies are reported in chapters covering issues of beamdynamics, technical subsystems, costs, and commissioning, reliability andupgradeability. Our detailed recommendations for the baselineconfiguration are given in Chapter 7, where we also outline furtherresearch and development that is needed before a machine using ourrecommended configuration can be built and operated successfully. In thesame chapter, we suggest possible alternatives to the baselineconfiguration.

  10. Cavity BPM System Tests for the ILC Spectrometer

    Energy Technology Data Exchange (ETDEWEB)

    Slater, M.

    2007-12-21

    The main physics program of the International Linear Collider (ILC) requires a measurement of the beam energy at the interaction point with an accuracy of 10{sup -4} or better. To achieve this goal a magnetic spectrometer using high resolution beam position monitors (BPMs) has been proposed. This paper reports on the cavity BPM system that was deployed to test this proposal. We demonstrate sub-micron resolution and micron level stability over 20 hours for a 1 m long BPM triplet. We find micron-level stability over 1 hour for 3 BPM stations distributed over a 30 m long baseline. The understanding of the behavior and response of the BPMs gained from this work has allowed full spectrometer tests to be carried out.

  11. Development of a China test cryomodule for ILC

    Institute of Scientific and Technical Information of China (English)

    XU Qing-Jin; ZONG Zhan-Guo; LIU Li-Qiang; ZHANG Liang; ZHAI Ji-Yuan; LI Chun-Hua; SUN Yi; HOU Zhi-Long; GAO Jie; ZHAO Tong-Xian; XIONG Lian-You; LU Wen-Hai

    2009-01-01

    Research and development of a 1.3 GHz 9-cell cavity test cryomodule were carried out by a collaboration group between IHEP (Institute of High Energy Physics) and TIPC (Technical Institute of Physics and Chemistry) in China.The cryomodule is a "test model" for the ILC cryomodule,and a key component of a superconducting accelerator test unit which will be built in the near future,also can be used as a horizontal test facility for 1.3 GHz 9-cell cavities.This paper presents the development status of the cryomodule,including structure design,cryogenic flow diagram,thermal and mechanical simulations,heat load estimation and etc.

  12. Photon collimator system for the ILC Positron Source

    CERN Document Server

    Riemann, S; Moortgat-Pick, G; Ushakov, A

    2014-01-01

    High energy e+e- linear colliders are the next large scale project in particle physics. They need intense sources to achieve the required luminosity. In particular, the positron source must provide about 10E+14 positrons per second. The positron source for the International Linear Collider (ILC) is based on a helical undulator passed by the electron beam to create an intense circularly polarized photon beam. With these photons a longitudinally polarized positron beam is generated; the degree of polarization can be enhanced by collimating the photon beam. However, the high photon beam intensity causes huge thermal load in the collimator material. In this paper the thermal load in the photon collimator is discussed and a flexible design solution is presented.

  13. Reconstruction of IP Beam Parameters at the ILC from Beamstraahlung

    CERN Document Server

    White, Glen

    2005-01-01

    The luminosity performance of the ILC will be very sensitive to the parameters of the colliding bunches. Only some of these parameters can be measured using planned instrumentation. This analysis aims to access some of the colliding beam parameters not available by other means and to improve on the resolution of those that are. GUINEA-PIG is used to simulate the beam-beam interactions and produce beamstrahlung radiation (e+/e- pairs and photons). These are tracked to a simulation of the low-angle Beam Calorimeter and a photon detector and event shapes are produced. A Taylor map is produced to transform from the event shapes to the simulated beam parameters. This paper reports on the progress of this analysis, examining the usefulness of the proposed fitting technique.

  14. Configuration Studies and Recommendations for the ILC DampingRings

    Energy Technology Data Exchange (ETDEWEB)

    Wolski, Andrzej; Gao, Jie; Guiducci, Susanna

    2006-02-04

    We describe the results of studies comparing differentoptions for the baseline configuration of the ILC damping rings. Theprincipal configuration decisions apply to the circumference, beamenergy, lattice type, and technology options for key components,including the injection/extraction kickers and the damping wigglers. Toarrive at our recommended configuration, we performed detailed studies ofa range of lattices representing a variety of different configurationoptions; these lattices are described in Chapter 2. The results of thevarious studies are reported in chapters covering issues of beamdynamics, technical subsystems, costs, and commissioning, reliability andupgradeability. Our detailed recommendations for the baselineconfiguration are given in Chapter 7, where we also outline furtherresearch and development that is needed before a machine using ourrecommended configuration can be built and operated successfully. In thesame chapter, we suggest possible alternatives to the baselineconfiguration.

  15. Configuration Studies and Recommendations for the ILC DampingRings

    Energy Technology Data Exchange (ETDEWEB)

    Wolski, Andrzej; Gao, Jie; Guiducci, Susanna

    2006-02-04

    We describe the results of studies comparing different options for the baseline configuration of the ILC damping rings. The principal configuration decisions apply to the circumference, beam energy, lattice type, and technology options for key components, including the injection/extraction kickers and the damping wigglers. To arrive at our recommended configuration, we performed detailed studies of a range of lattices representing a variety of different configuration options; these lattices are described in Chapter 2. The results of the various studies are reported in chapters covering issues of beam dynamics, technical subsystems, costs, and commissioning, reliability and upgrade ability. Our detailed recommendations for the baseline configuration are given in Chapter 7, where we also outline further research and development that is needed before a machine using our recommended configuration can be built and operated successfully. In the same chapter, we suggest possible alternatives to the baseline configuration.

  16. Low Emittance Guns for the ILC Polarized Electron Beam

    Science.gov (United States)

    Clendenin, J. E.; Brachmann, A.; Ioakeimidi, K.; Kirby, R. E.; Maruyama, T.; Miller, R. H.; Wang, J. W.; Zhou, F.

    2007-06-01

    Polarized electron beams generated by DC guns are routinely available at several accelerators including JLAB, Mainz and SLAC. These guns operate with a cathode bias on the order of -100 kV. To minimize space charge effects, relatively long bunches are generated at the gun and then compressed longitudinally external to the gun just before and during initial acceleration. For linear colliders, this compression is accomplished using a combination of rf bunchers. For the basic design of the International Linear Collider (ILC), a 120 kV DC photocathode gun is used to produce a series of nanosecond bunches that are each compressed by two sub-harmonic bunchers (SHBs) followed by an L-band buncher and capture section. The longitudinal bunching process results in a significantly higher emittance than produced by the gun alone. While high-energy experiments using polarized beams are not generally sensitive to the source emittance, there are several benefits to a lower source emittance including a simpler more efficient injector system and a lower radiation load during transport especially at bends as at the damping ring. For the ILC, the SHBs could be eliminated if the voltage of the gun is raised sufficiently. Simulations using the General Particle Tracer (GPT) package indicate that a cathode bias voltage of ⩾200 kV should allow both SHBs to be operated at 433 or even 650 MHz, while ⩾500 kV would be required to eliminate the SHBs altogether. Simulations can be used to determine the minimum emittance possible if the injector is designed for a given increased voltage. A possible alternative to the DC gun is an rf gun. Emittance compensation, routinely used with rf guns, is discussed for higher-voltage DC guns.

  17. Influence of dysprosium substitution on magnetic and mechanical properties of high intrinsic coercivity Nd-Fe-B magnets prepared by double-alloy powder mixed method

    Institute of Scientific and Technical Information of China (English)

    胡志华; 瞿海锦; 马冬威; 罗成; 王会杰

    2016-01-01

    The double-alloy powder mixed method is very proper for developing new small-mass products by changing the composi-tion of sintered Nd-Fe-B magnets, and there is little research on this aspect. The variation on magnetic and mechanical properties of high intrinsic coercivity Nd-Fe-B magnets prepared by double-alloy powder mixed method was discussed, which is a method blend-ing two-type main phase alloy powders with different components. The results showed that the intrinsic coercivity and density of sin-tered Nd-Fe-B magnets increased gradually with the increase in Dy content, and the double-alloy powder mixed method could obtain high intrinsic coercivity Nd-Fe-B magnets with good crystallographic alignment and microstructure. The bending strength of sintered Nd-Fe-B magnets declined, and the Rockwell hardness of sintered Nd-Fe-B magnets first declined, and then increased with the in-crease in Dy content. The microstructure showed that there existed the phenomenon that the Dy element diffused into main phase dur-ing sintering process, and the distribution of Dy content in main phase had some variation in homogeneity as a result of incomplete reaction between the double-alloy powder types.

  18. Impacts of thermal stress and doping on intrinsic point defect properties and clustering during single crystal silicon and germanium growth from a melt

    Science.gov (United States)

    Vanhellemont, Jan; Kamiyama, Eiji; Nakamura, Kozo; Śpiewak, Piotr; Sueoka, Koji

    2017-09-01

    This paper reviews recent considerable progress made in the last few years in understanding the behavior and properties of intrinsic point defects close to moving melt/solid Si interfaces during single crystal Si growth from a melt. The so called Voronkov criterion allows to determine whether the grown Si crystal is interstitial I- or vacancy V-rich. This criterion is written as the ratio Γ of the pulling rate v over the thermal gradient G at the interface. Crystals pulled with Γ above a critical value Γcrit are vacancy-rich while below Γcrit, they are interstitial-rich. Various expressions based on the intrinsic point defect thermal equilibrium concentration and diffusivity have been proposed to calculate Γcrit and are briefly discussed in this paper. Recently it was shown that the thermal stress at the interface and heavy doping with neutral and/or electrically active impurities, have a considerable impact on the intrinsic point defect balance and thus also on Γcrit. Furthermore, high energy barriers of formation energies of I and V around three or four atom layers from (001) free surface support a model in which the boundary conditions of the point defect concentrations at the surface in simulations can be set at fixed values. The situation is quite different for Ge single crystal pulling where the vacancy is always the dominant intrinsic point defect so that the Voronkov criterion cannot be applied. Prediction of vacancy cluster concentration/size distributions as a function of the pulling conditions is however still possible. The possibility of reaching Voronkov criterion conditions for Ge by doping with specific impurities is also discussed. Finally, impacts of stress and doping on self-diffusion in Si and Ge are evaluated with comparing the previous experimental results.

  19. Interim report on the Global Design Effort Global International Linear Collider (ILC) R&D

    Energy Technology Data Exchange (ETDEWEB)

    Harrison, M.

    2011-04-30

    The International Linear Collider: A Technical Progress Report marks the halfway point towards the Global Design Effort fulfilling its mandate to follow up the ILC Reference Design Report with a more optimised Technical Design Report (TDR) by the end of 2012. The TDR will be based on much of the work reported here and will contain all the elements needed to propose the ILC to collaborating governments, including a technical design and implementation plan that are realistic and have been better optimised for performance, cost and risk. We are on track to develop detailed plans for the ILC, such that once results from the Large Hadron Collider (LHC) at CERN establish the main science goals and parameters of the next machine, we will be in good position to make a strong proposal for this new major global project in particle physics. The two overriding issues for the ILC R&D programme are to demonstrate that the technical requirements for the accelerator are achievable with practical technologies, and that the ambitious physics goals can be addressed by realistic ILC detectors. This GDE interim report documents the impressive progress on the accelerator technologies that can make the ILC a reality. It highlights results of the technological demonstrations that are giving the community increased confidence that we will be ready to proceed with an ILC project following the TDR. The companion detector and physics report document likewise demonstrates how detector designs can meet the ambitious and detailed physics goals set out by the ILC Steering Committee. LHC results will likely affect the requirements for the machine design and the detectors, and we are monitoring that very closely, intending to adapt our design as those results become available.

  20. A Study of Laser System Requirements for Application in Beam Diagnostics And Polarimetry at the ILC

    Energy Technology Data Exchange (ETDEWEB)

    Dixit, S.; Delerue, N.; Foster, B.; Howell, D.F.; Peach, K.; Quelch, G.; Qureshi, M.; Reichold, A.; /Oxford U.; Hirst, G.; Ross, I.; /Rutherford; Urakawa, J.; /KEK,; Soskov, V.; Variola, A.; Zomer, F.; /Orsay, LAL; Blair, G.A.; Boogert, S.T.; Boorman, G.; Bosco, A.; Driouichi, C.; Karataev, P.; /Royal Holloway, U. of London; Brachmann,; /SLAC

    2007-02-12

    Advanced laser systems will be essential for a range of diagnostics devices and polarimetry at the ILC. High average power, high beam quality, excellent stability and reliability will be crucial in order to deliver the information required to attain the necessary ILC luminosity as well as for efficient polarimetry. The key parameters are listed together with the R & D required to achieve the necessary laser system performance.

  1. A teststand for photo detectors and beamtests for ILC polarimetry; Aufbau eines Teststandes fuer Photodetektoren und Teststrahlmessungen fuer die Strahlpolarisationsmessung am ILC

    Energy Technology Data Exchange (ETDEWEB)

    Velte, Ulrich

    2009-02-15

    In the future International Linear Collider (ILC) up to 80% polarized electrons shall be brought to collision with up to 60% polarized positrons. Because the cross sections of the resulting reactions depend sensitively on the beam polarization this must be measured with a hitherto never reached accuracy of {delta}P/P{approx}0.25%. This shall be reached via Compton scattering of laser photons from the beam particles and subsequent detection of the scattered electrons in a Cherenkov hodoscope. Content of this thesis was to build a teststand, in which different photodetectors for the detection of the Cherenkov light can be characterized and checked on their suitability for the special application in the ILC polarimeter. The until now best polarization measurement was reached in the framework of the SLD experiment at SLAC in California ({delta}P/P{approx}0.5%). At present the Cherenkov counter of the SLD polarimeter is at DESY and is their used in order to measure different photodetectors coming into question for the ILC polarimetry in the test beam. In order to be able to continue the experiences from the SLD experiment in the framework of this thesis test-beam measurements at the Cherenkov detector are evaluated and the first developments towards a polarimeter for the ILC described. [German] Im zukuenftigen International Linear Collider (ILC) sollen bis zu 80% polarisierte Elektronen mit bis zu 60% polarisierten Positronen zur Kollision gebracht werden. Da die Wirkungsquerschnitte der resultierenden Reaktionen empfindlich von der Strahlpolarisation abhaengen, muss diese mit einer bisher nie erreichten Genauigkeit von {delta}P/P{approx}0.25% gemessen werden. Dies soll ueber Compton-Streuung von Laserphotonen an den Strahlteilchen und anschliessendem Nachweis der gestreuten Elektronen in einem Cerenkov-Hodoskop erreicht werden. Inhalt dieser Arbeit war es, einen Teststand aufzubauen, in dem verschiedenartige Photodetektoren zum Nachweis des Cerenkov

  2. Carbon Dots with Intrinsic Theranostic Properties for Bioimaging, Red-Light-Triggered Photodynamic/Photothermal Simultaneous Therapy In Vitro and In Vivo.

    Science.gov (United States)

    Ge, Jiechao; Jia, Qingyan; Liu, Weimin; Lan, Minhuan; Zhou, Bingjiang; Guo, Liang; Zhou, Hangyue; Zhang, Hongyan; Wang, Ying; Gu, Ying; Meng, Xiangmin; Wang, Pengfei

    2016-03-01

    Cancer nanotheranostics combining therapeutic and imaging functions within a single nanoplatform are extremely important for nanomedicine. In this study, carbon dots (C-dots) with intrinsic theranostic properties are prepared by using polythiophene benzoic acid as carbon source. The obtained C-dots absorb light in the range of 400-700 nm and emit bright fluorescence in the red region (peaking from 640 to 680 nm at different excitations). More importantly, the obtained C-dots exhibit dual photodynamic and photothermal effects under 635 nm laser irradiation with a singlet oxygen ((1)O2) generating efficiency of 27% and high photothermal conversion efficiency of 36.2%. These unique properties enable C-dots to act as a red-light-triggered theranostic agent for imaging-guided photodynamic-photothermal simultaneous therapy in vitro and in vivo within the therapeutic window (600-1000 nm).

  3. Critical role of fatty acid metabolism in ILC2-mediated barrier protection during malnutrition and helminth infection.

    Science.gov (United States)

    Wilhelm, Christoph; Harrison, Oliver J; Schmitt, Vanessa; Pelletier, Martin; Spencer, Sean P; Urban, Joseph F; Ploch, Michelle; Ramalingam, Thirumalai R; Siegel, Richard M; Belkaid, Yasmine

    2016-07-25

    Innate lymphoid cells (ILC) play an important role in many immune processes, including control of infections, inflammation, and tissue repair. To date, little is known about the metabolism of ILC and whether these cells can metabolically adapt in response to environmental signals. Here we show that type 2 innate lymphoid cells (ILC2), important mediators of barrier immunity, predominantly depend on fatty acid (FA) metabolism during helminth infection. Further, in situations where an essential nutrient, such as vitamin A, is limited, ILC2 sustain their function and selectively maintain interleukin 13 (IL-13) production via increased acquisition and utilization of FA. Together, these results reveal that ILC2 preferentially use FAs to maintain their function in the context of helminth infection or malnutrition and propose that enhanced FA usage and FA-dependent IL-13 production by ILC2 could represent a host adaptation to maintain barrier immunity under dietary restriction.

  4. From the intrinsic properties to the functional role of a neuron phenotype: an example from electric fish during signal trade-off.

    Science.gov (United States)

    Nogueira, Javier; Caputi, Angel A

    2013-07-01

    This review deals with the question: what is the relationship between the properties of a neuron and the role that the neuron plays within a given neural circuit? Answering this kind of question requires collecting evidence from multiple neuron phenotypes and comparing the role of each type in circuits that perform well-defined computational tasks. The focus here is on the spherical neurons in the electrosensory lobe of the electric fish Gymnotus omarorum. They belong to the one-spike-onset phenotype expressed at the early stages of signal processing in various sensory modalities and diverse taxa. First, we refer to the one-spike neuron intrinsic properties, their foundation on a low-threshold K(+) conductance, and the potential roles of this phenotype in different circuits within a comparative framework. Second, we present a brief description of the active electric sense of weakly electric fish and the particularities of spherical one-spike-onset neurons in the electrosensory lobe of G. omarorum. Third, we introduce one of the specific tasks in which these neurons are involved: the trade-off between self- and allo-generated signals. Fourth, we discuss recent evidence indicating a still-undescribed role for the one-spike phenotype. This role deals with the blockage of the pathway after being activated by the self-generated electric organ discharge and how this blockage favors self-generated electrosensory information in the context of allo-generated interference. Based on comparative analysis we conclude that one-spike-onset neurons may play several functional roles in animal sensory behavior. There are specific adaptations of the neuron's 'response function' to the circuit and task. Conversely, the way in which a task is accomplished depends on the intrinsic properties of the neurons involved. In short, the role of a neuron within a circuit depends on the neuron and its functional context.

  5. Optimization of Helium Vessel Design for ILC Cavities

    Energy Technology Data Exchange (ETDEWEB)

    Fratangelo, Enrico [Univ. of Pisa (Italy)

    2009-01-01

    The ILC (International Linear Collider) is a proposed new major particle accelerator. It consists of two 20 km long linear accelerators colliding electrons and positrons at an energy exceeding 500 GeV, Achieving this collision energy while keeping reasonable accelerator dimensions requires the use of high electric field superconducting cavities as the main acceleration element. These cavities are operated at l.3 GHz inside an appropriate container (He vessel) at temperatures as low as 1.4 K using superfluid Helium as the refrigerating medium. The purpose of this thesis, in the context of the ILC R&D activities currently in progress at Fermilab (Fermi National Accelerator Laboratory), is the mechanical study of an ILC superconducting cavity and Helium vessel prototype. The main goals of these studies are the determination of the limiting working conditions of the whole He vessel assembly, the simulation of the manufacturing process of the cavity end-caps and the assessment of the Helium vessel's efficiency. In addition this thesis studies the requirements to certify the compliance with the ASME Code of the whole cavity/vessel assembly. Several Finite Elements Analyses were performed by the candidate himself in order to perform the studies listed above and described in detail in Chapters 4 through 8. ln particular the candidate has developed an improved procedure to obtain more accurate results with lower computational times. These procedures will be accurately described in the following chapters. After an introduction that briefly describes the Fennilab and in particular the Technical Division (where all the activities concerning with this thesis were developed), the first part of this thesis (Chapters 2 and 3) explains some of the main aspects of modem particle accelerators. Moreover it describes the most important particle accelerators working at the moment and the basic features of the ILC project. Chapter 4 describes all the activities that were done to

  6. Optimization of the Low Loss SRF Cavity for the ILC

    Energy Technology Data Exchange (ETDEWEB)

    Sekutowicz, J.S.; /DESY; Kneisel, P.; /Jefferson Lab; Higo, T.; Morozumi, Y.; Saito, K.; /KEK, Tsukuba; Ge, L.; Ko, Yong-kyu; Lee, L.; Li, Z.; Ng, C.K.; Schussman, G.L.; Xiao, L.; /SLAC

    2008-01-18

    The Low-Loss shape cavity design has been proposed as a possible alternative to the baseline TESLA cavity design for the ILC main linacs. The advantages of this design over the TESLA cavity are its lower cryogenic loss, and higher achievable gradient due to lower surface fields. High gradient prototypes for such designs have been tested at KEK (ICHIRO) and TJNAF (LL). However, issues related to HOM damping and multipacting still need to be addressed. Preliminary numerical studies of the prototype cavities have shown unacceptable damping factors for some higher-order dipole modes if the typical TESLA HOM couplers are directly adapted to the design. The resulting wakefield will dilute the beam emittance thus reducing the machine luminosity. Furthermore, high gradient tests on a 9-cell prototype at KEK have experienced multipacting barriers although a single LL cell had achieved a high gradient. From simulations, multipacting activities are found to occur in the end-groups of the cavity. In this paper, we will present the optimization results of the end-groups for the Low-Loss designs for effective HOM damping and alleviation of multipacting.

  7. Precision Natural SUSY at CEPC, FCC-ee, and ILC

    CERN Document Server

    Fan, JiJi; Wang, Lian-Tao

    2014-01-01

    Testing the idea of naturalness is and will continue to be one of the most important goals of high energy physics experiments. It will play a central role in the physics program of future colliders. In this paper, we present projections of the reach of natural SUSY at future lepton colliders: CEPC, FCC-ee and ILC. We focus on the observables which give the strongest reach, the electroweak precision observables (for left-handed stops), and Higgs to gluon and photon decay rates (for both left- and right-handed stops). There is a "blind spot" when the stop mixing parameter Xt is approximately equal to the average stop mass. We argue that in natural scenarios, bounds on the heavy Higgs bosons from tree-level mixing effects that modify the bottom Yukawa coupling together with bounds from b to s gamma play a complementary role in probing the blind spot region. For specific natural SUSY scenarios such as folded SUSY in which the top partners do not carry Standard Model color charges, electroweak precision observable...

  8. Development of a TPC for an ILC Detector

    CERN Document Server

    Diener, R

    2012-01-01

    The ILD concept, one of two proposed detector concepts for the planned International Linear Collider (ILC), foresees a Time Projection Chamber (TPC) as the main tracking detector. The LCTPC (Linear Collider TPC) collaboration pursues R&D to develop such a TPC based on the best state-of-the-art technology. After tests with smaller prototypes, the current efforts focus on studies using a large prototype with a diameter of 770 mm and a length of 610 mm. This prototype can accommodate seven read-out modules of a size comparable to the ones that would be used in the final TPC. Several prototypes of modules using Micromegas or GEM structures as gas amplification were constructed and tested. Besides the traditional pad read-out, a pixel read-out based on the TimePix chip is studied in these tests with up to 8 TimePix chips on a board. The current status and future plans of the R&D are presented.

  9. Intrinsic Properties of immunoglobulin IgG1 Isotype-Switched B Cell Receptors Promote Microclustering and the Initiation of Signaling

    Science.gov (United States)

    Liu, Wanli; Meckel, Tobias; Tolar, Pavel; Sohn, Hae Won; Pierce, Susan K.

    2010-01-01

    Summary Memory B cells express high affinity, immunoglobulin B cell receptors (IgG-BCRs) that enhance B cell responses giving rise to the rapid production of high affinity, IgG antibodies. Despite the central role of IgG-BCRs in memory responses, the mechanisms by which the IgG-BCRs function to enhance B cell responses are not fully understood. Using high-resolution live-cell imaging we showed that independent of affinity, IgG1-BCRs dramatically enhanced the earliest BCR-intrinsic events that followed within seconds of B cells’ encounter with membrane bound antigen including BCR oligomerization and BCR microcluster growth, leading to Syk kinase recruitment and calcium responses. The enhancement of these early events was dependent on a membrane proximal region of the IgG1 cytoplasmic tail not previously appreciated to play a role in IgG1-BCR signaling. Thus, intrinsic properties of the IgG1-BCR enhance early antigen-driven events that ultimately translate into heightened signaling. PMID:20620943

  10. International Linear Collider Reference Design Report Volume 2: Physics at the ILC

    Energy Technology Data Exchange (ETDEWEB)

    Aarons, Gerald; Abe, Toshinori; Abernathy, Jason; Ablikim, Medina; Abramowicz, Halina; Adey, David; Adloff, Catherine; Adolphsen, Chris; Afanaciev, Konstantin; Agapov, Ilya; Ahn, Jung-Keun; Aihara, Hiroaki; Akemoto, Mitsuo; del Carmen Alabau, Maria; Albert, Justin; Albrecht, Hartwig; Albrecht, Michael; Alesini, David; Alexander, Gideon; Alexander, Jim; Allison, Wade; /SLAC /Tokyo U. /Victoria U. /Beijing, Inst. High Energy Phys. /Tel Aviv U. /Birmingham U. /Annecy, LAPP /Minsk, High Energy Phys. Ctr. /DESY /Royal Holloway, U. of London /CERN /Pusan Natl. U. /KEK, Tsukuba /Orsay, LAL /Notre Dame U. /Frascati /Cornell U., Phys. Dept. /Oxford U. /Hefei, CUST /Bangalore, Indian Inst. Sci. /Fermilab

    2011-11-14

    and weak forces, which are observed by experiments in very different forms. So far, there is no direct experimental evidence for a Higgs field or the Higgs particle that should accompany it. Furthermore, quantum effects of the type already observed in experiments should destabilize the Higgs boson of the Standard Model, preventing its operation at Terascale energies. The proposed antidotes for this quantum instability mostly involve dramatic phenomena at the Terascale: new forces, a new principle of nature called supersymmetry, or even extra dimensions of space. Thus for particle physicists the Higgs boson is at the center of a much broader program of discovery, taking off from a long list of questions. Is there really a Higgs boson? If not, what are the mechanisms that give mass to particles and break the electroweak force? If there is a Higgs boson, does it differ from the hypothetical Higgs of the Standard Model? Is there more than one Higgs particle? What are the new phenomena that stabilize the Higgs boson at the Terascale? What properties of Higgs boson inform us about these new phenomena? Another major opportunity for the ILC is to shed light on the dark side of the universe. Astrophysical data shows that dark matter dominates over visible matter, and that almost all of this dark matter cannot be composed of known particles. This data, combined with the concordance model of Big Bang cosmology, suggests that dark matter is comprised of new particles that interact weakly with ordinary matter and have Terascale masses. It is truely remarkable that astrophysics and cosmology, completely independently of the particle physics considerations reviewed above, point to new phenomena at the Terascale. If Terascale dark matter exists, experiments at the ILC should be able to produce such particles in the laboratory and study their properties. Another list of questions will then beckon. Do these new particles really have the correct properties to be the dark matter? Do they

  11. International Linear Collider Reference Design Report Volume 2: Physics at the ILC

    Energy Technology Data Exchange (ETDEWEB)

    Aarons, Gerald; Abe, Toshinori; Abernathy, Jason; Ablikim, Medina; Abramowicz, Halina; Adey, David; Adloff, Catherine; Adolphsen, Chris; Afanaciev, Konstantin; Agapov, Ilya; Ahn, Jung-Keun; Aihara, Hiroaki; Akemoto, Mitsuo; del Carmen Alabau, Maria; Albert, Justin; Albrecht, Hartwig; Albrecht, Michael; Alesini, David; Alexander, Gideon; Alexander, Jim; Allison, Wade; /SLAC /Tokyo U. /Victoria U. /Beijing, Inst. High Energy Phys. /Tel Aviv U. /Birmingham U. /Annecy, LAPP /Minsk, High Energy Phys. Ctr. /DESY /Royal Holloway, U. of London /CERN /Pusan Natl. U. /KEK, Tsukuba /Orsay, LAL /Notre Dame U. /Frascati /Cornell U., Phys. Dept. /Oxford U. /Hefei, CUST /Bangalore, Indian Inst. Sci. /Fermilab

    2011-11-14

    and weak forces, which are observed by experiments in very different forms. So far, there is no direct experimental evidence for a Higgs field or the Higgs particle that should accompany it. Furthermore, quantum effects of the type already observed in experiments should destabilize the Higgs boson of the Standard Model, preventing its operation at Terascale energies. The proposed antidotes for this quantum instability mostly involve dramatic phenomena at the Terascale: new forces, a new principle of nature called supersymmetry, or even extra dimensions of space. Thus for particle physicists the Higgs boson is at the center of a much broader program of discovery, taking off from a long list of questions. Is there really a Higgs boson? If not, what are the mechanisms that give mass to particles and break the electroweak force? If there is a Higgs boson, does it differ from the hypothetical Higgs of the Standard Model? Is there more than one Higgs particle? What are the new phenomena that stabilize the Higgs boson at the Terascale? What properties of Higgs boson inform us about these new phenomena? Another major opportunity for the ILC is to shed light on the dark side of the universe. Astrophysical data shows that dark matter dominates over visible matter, and that almost all of this dark matter cannot be composed of known particles. This data, combined with the concordance model of Big Bang cosmology, suggests that dark matter is comprised of new particles that interact weakly with ordinary matter and have Terascale masses. It is truely remarkable that astrophysics and cosmology, completely independently of the particle physics considerations reviewed above, point to new phenomena at the Terascale. If Terascale dark matter exists, experiments at the ILC should be able to produce such particles in the laboratory and study their properties. Another list of questions will then beckon. Do these new particles really have the correct properties to be the dark matter? Do they

  12. Differential geometry of the ruled surfaces optically generated by mirror-scanning devices. I. Intrinsic and extrinsic properties of the scan field.

    Science.gov (United States)

    Li, Yajun

    2011-04-01

    Rectilinear propagation of light rays in homogeneous isotropic media makes it possible for optical generation of ruled surfaces as the ray is deflected by a rotatable mirror. Scan patterns on a plane or curved surface are merely curves on the ruled surface. Based on this understanding, structures of the scan fields produced by mirror-scanning devices of different configurations are investigated in terms of differential geometry. Expressions of the first and second fundamental coefficients and the first and second Gauss differential forms are given for an investigation of the intrinsic properties of the optically generated ruled surfaces. The Plücker ruled conoid is then generalized for mathematical modeling of the scan fields produced by single-mirror scanning devices of different configurations. Part II will be devoted to a study of multi-mirror scanning systems for optical generation of well-known ruled surfaces such as helicoids and hyperbolic paraboloids.

  13. The ILC engineering design phase: Towards the production of an engineering design report

    Energy Technology Data Exchange (ETDEWEB)

    Ross, Marc; /Fermilab

    2007-01-01

    In August 2007, the International Linear Collider-Global Design Effort (ILC-GDE) published the ILC Reference Design Report (RDR) which contains a description of the design of the linear collider and a ''value'' cost estimate. The RDR was developed over a 2 year period starting in August 2005 with the creation of the GDE at the Second ILC workshop, held at Snowmass, Colorado. The design described in the RDR and its associated estimate allow the GDE to plan and prioritize the next phase of the ILC, the creation of an Engineering Design and the production, by mid 2010, of an Engineering Design Report (EDR). The EDR will contain, in addition to a more mature design and an updated value estimate, a plan for executing the ILC Project. The purpose of the EDR is to facilitate formal international negotiations at government level on siting, funding, organization and execution of the ILC project with a timescale consistent with the start of construction in 2012. The creation of the ILC Engineering Design will include: (1) Basic R&D to demonstrate that all components can be engineered; (2) R&D into alternative solutions to mitigate remaining risk; (3) An overall design to allow machine construction to start within 3 years following its completion; (4) selection between high tech options to allow industrialization efforts; (5) A comprehensive value-engineering exercise; (6) A complete value cost estimate for the machine, including a funding profile consistent with the project schedule; (7) A project execution plan including a realistic schedule; (8) Designs for facilities shared between different ''area systems'', and for site-specific infrastructure. The designs must include the level of detail needed for regions to estimate the cost to host; and (9) All necessary information must be provided to regions to evaluate project technical and financial risks in support of a bid to host. With the completion of the EDR, the ILC-GDE leadership

  14. Study of a DEPFET vertex detector and of supersymmetric smuons at the ILC

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Xun

    2009-01-21

    This thesis is devoted to the study of the performance of a pixel vertex detector based on DEPFET technology at the International Linear Collider (ILC). The ILC is the proposed next generation e{sup +}e{sup -} collider to explore the physics at the Terascale. At the ILC with its well-defined initial state of collisions, possible discoveries at the Large Hadron Collider can be verified and studied more accurately. It is expected that the precision measurements of the ILC will answer many fundamental questions about the universe, such as the generation of particle masses and the origin of electroweak spontaneous symmetry breaking. The ambitious physics goals present challenges to the ILC detectors. Several detector concepts have been proposed in recent years. A crucial device for all these concepts is the pixel vertex detector. It provides precise impact parameter information of charged particles, jet flavor tagging and improves overall tracking efficiency. To meet the requirements of the ILC environment, the vertex detector will be arranged in a concentric multi-layer array around the interaction point to cover as large a solid angle as possible. Endcap disks are considered in some designs. Silicon pixel sensor technologies must be employed to provide excellent point resolution. The DEPFET technology, which integrates the first level of amplification into a depleted silicon bulk, is one of the promising candidates. The DEPFET sensor is very sensitive with a high signal-to-noise ratio. Power consumption is minimized due to the internal storage of signal charges. The good radiation tolerance makes it capable of working close to the interaction point. In this thesis, we discuss the detailed simulation of the DEPFET vertex detector, following the general vertex detector layout proposed by the TESLA collaboration. The simulation is used to evaluate the impact parameter resolution. We also discuss the DEPFET test beam analysis on two-track resolution. The whole analysis

  15. A new approach for improving diagnostic accuracy in Alzheimer's disease and frontal lobe dementia utilising the intrinsic properties of the SPET dataset

    Energy Technology Data Exchange (ETDEWEB)

    Pagani, Marco [Institute of Cognitive Sciences and Technology, CNR, Viale Marx 15, 00137, Rome (Italy); Section of Nuclear Medicine, Karolinska Hospital/Institute, Stockholm (Sweden); Kovalev, Vassili A. [Institute of Engineering Cybernetics, Belarus National Academy of Sciences, Minsk (Belarus); Max-Planck Institute of Cognitive Neuroscience, Leipzig (Germany); Lundqvist, Roger; Thurfjell, Lennart [Applied Medical Imaging, Uppsala (Sweden); Jacobsson, Hans [Section of Nuclear Medicine, Karolinska Hospital/Institute, Stockholm (Sweden); Department of Radiology, Karolinska Hospital, Stockholm (Sweden); Larsson, Stig A. [Section of Nuclear Medicine, Karolinska Hospital/Institute, Stockholm (Sweden)

    2003-11-01

    Alzheimer's disease (AD) and frontal lobe dementia (FLD) show characteristic patterns of regional cerebral blood flow (rCBF). However, these patterns may overlap with those observed in the aging brain in elderly normal individuals. The aim of this study was to develop a new method for better classification and recognition of AD and FLD cases as compared with normal controls. Forty-six patients with AD, 7 patients with FLD and 34 normal controls (CTR) were included in the study. rCBF was assessed by technetium-99m hexamethylpropylene amine oxime and a three-headed single-photon emission tomography (SPET) camera. A brain atlas was used to define volumes of interest (VOIs) corresponding to the brain lobes. In addition to conventional image processing methods, based on count density/voxel, the new approach also analysed other intrinsic properties of the data by means of gradient computation steps. Hereby, five factors were assessed and tested separately: the mean count density/voxel and its histogram, the mean gradient and its histogram, and the gradient angle co-occurrence matrix. A feature vector concatenating single features was also created and tested. Preliminary feature discrimination was performed using a two-sided t-test and a K-means clustering was then used to classify the image sets into categories. Finally, five-dimensional co-occurrence matrices combining the different intrinsic properties were computed for each VOI, and their ability to recognise the group to which each individual scan belonged was investigated. For correct classification of the AD-CTR groups, the gradient histogram in the parieto-temporal lobes was the most useful single feature (accuracy 91%). FLD and CTR were better classified by the count density/voxel histogram (frontal and occipital lobes) and by the mean gradient (frontal, temporal and parietal lobes, accuracy 98%). For AD and FLD the count density/voxel histogram in the frontal, parietal and occipital lobes classified the

  16. AHR prevents human IL-1R1hi ILC3 differentiation to natural killer cells

    Science.gov (United States)

    Hughes, Tiffany; Briercheck, Edward L.; Freud, Aharon G.; Trotta, Rossana; McClory, Susan; Scoville, Steven D.; Keller, Karen; Deng, Youcai; Cole, Jordan; Harrison, Nicholas; Mao, Charlene; Zhang, Jianying; Benson, Don M.; Yu, Jianhua; Caligiuri, Michael A.

    2014-01-01

    SUMMARY Accumulating evidence indicates that human natural killer (NK) cells develop in secondary lymphoid tissue (SLT) through a so-called “stage 3” developmental intermediate minimally characterized by a CD34-CD117+CD94- immunophenotype that lacks mature NK cell function. This stage 3 population is heterogeneous, potentially composed of functionally distinct innate lymphoid cell (ILC) types that includes interleukin-1 receptor (IL-1R1) positive, IL-22-producing ILC3s. Whether human ILC3s are developmentally related to NK cells is a subject of ongoing investigation. Here we show that antagonism of the aryl hydrocarbon receptor (AHR) or silencing of AHR gene expression promotes differentiation of tonsillar IL-22-producing IL-1R1hi human ILC3s to CD56brightCD94+ IFN-gamma-producing cytolytic mature NK cells expressing eomesodermin (EOMES) and T-Box Protein 21 (TBX21 or TBET). Hence, AHR is a transcription factor that prevents human IL-1R1hi ILC3s from differentiating into NK cells. PMID:24953655

  17. Discriminators of 2 Higgs Doublets at the LHC14, ILC and MuonCollider(125): A Snowmasss White Paper

    CERN Document Server

    Barger, Vernon; Logan, Heather E; Shaughnessy, Gabe

    2013-01-01

    The historic LHC discovery of the 125 GeV particle with properties that closely resemble the Standard Model (SM) Higgs boson verifies our understanding of electroweak symmetry breaking, but solidifies the need for a resolution to the hierarchy problem. Many extensions of the SM that address the hierarchy problem contain a non-minimal Higgs sector. Therefore, as a benchmark alternative to the SM Higgs mechanism, we study a general 2 Higgs doublet model (2HDM-G) framework for evaluating future sensitivity to Higgs couplings. We study how well it can be distinguished from the SM Higgs boson by future measurements at LHC14, ILC (250, 500,1000 GeV) and a Muon Collider (125 GeV). Additionally, our study bears on singlet Higgs extensions of two Higgs doublet models through predicted coupling relationships.

  18. α4β2 nicotinic acetylcholine receptor partial agonists with low intrinsic efficacy have antidepressant-like properties

    Science.gov (United States)

    Mineur, Yann S.; Einstein, Emily B.; Seymour, Patricia A.; Coe, Jotham W.; O’Neill, Brian T.; Rollema, Hans

    2011-01-01

    Previous studies have suggested that treatment with antagonists or partial agonists of nicotinic acetylcholine receptors containing the β2 subunit (β2* nAChRs) results in antidepressant-like effects. In the current study we tested 3 novel compounds with different affinity and functional efficacy at α4β2* nAChRs, which were synthesized as part of nAChR discovery projects at Pfizer in the tail suspension, forced swim and novelty-suppressed feeding tests of antidepressant efficacy. All compounds tested reduced immobility in the forced swim test and one of the compounds also reduced immobility in the tail suspension test. All the compounds appeared to affect food intake on their own, with 2 compounds reducing feeding significantly in the home cage, precluding a clear interpretation of the results in the novelty-suppressed feeding test. None of the compounds altered locomotor activity at the doses and time points used here. Therefore, a subset of these compounds has pharmacological and behavioral properties that demonstrate the potential of nicotinic compounds as a treatment of mood disorders. Further development of nicotinic-based antidepressants should focus on increasing nAChR subtype selectivity to obtain consistent antidepressant properties with an acceptable side effect profile. PMID:21566524

  19. The acute effect of bipolar radiofrequency energy thermal chondroplasty on intrinsic biomechanical properties and thickness of chondromalacic human articular cartilage.

    Science.gov (United States)

    Dutcheshen, Nicholas; Maerz, Tristan; Rabban, Patrick; Haut, Roger C; Button, Keith D; Baker, Kevin C; Guettler, Joseph

    2012-08-01

    Radio frequency energy (RFE) thermal chondroplasty has been a widely-utilized method of cartilage debridement in the past. Little is known regarding its effect on tissue mechanics. This study investigated the acute biomechanical effects of bipolar RFE treatment on human chondromalacic cartilage. Articular cartilage specimens were extracted (n = 50) from femoral condyle samples of patients undergoing total knee arthroplasty. Chondromalacia was graded with the Outerbridge classification system. Tissue thicknesses were measured using a needle punch test. Specimens underwent pretreatment load-relaxation testing using a spherical indenter. Bipolar RFE treatment was applied for 45 s and the indentation protocol was repeated. Structural properties were derived from the force-time data. Mechanical properties were derived using a fibril-reinforced biphasic cartilage model. Statistics were performed using repeated measures ANOVA. Cartilage thickness decreased after RFE treatment from a mean of 2.61 mm to 2.20 mm in Grade II, II-III, and III specimens (P resistance to shear and tension could be compromised due to removal of the superficial layer and decreased fibril modulus, RFE treatment increases matrix modulus and decreases tissue permeability which may restore the load- bearing capacity of the cartilage.

  20. Critical role of fatty acid metabolism in ILC2 mediated barrier protection during malnutrition and helminth infection

    Science.gov (United States)

    Innate lymphoid cells (ILCs) play an important role in many immune processes, including control of infections, inflammation and tissue repair. To date little is known about the metabolism of ILCs under steady-state conditions and infection, and whether these cells can metabolically adapt in response...

  1. Intrinsic Depletion or Not

    DEFF Research Database (Denmark)

    Klösgen, Beate; Bruun, Sara; Hansen, Søren;

    with an AFM (2).    The intuitive explanation for the depletion based on "hydrophobic mismatch" between the obviously hydrophilic bulk phase of water next to the hydrophobic polymer. It would thus be an intrinsic property of all interfaces between non-matching materials. The detailed physical interaction path......  The presence of a depletion layer of water along extended hydrophobic interfaces, and a possibly related formation of nanobubbles, is an ongoing discussion. The phenomenon was initially reported when we, years ago, chose thick films (~300-400Å) of polystyrene as cushions between a crystalline...

  2. Strain dependence of critical superconducting properties of Nb3Sn with different intrinsic strains based on a semi-phenomenological approach

    Science.gov (United States)

    Zhang, Rui; Gao, Peifeng; Wang, Xingzhe

    2017-09-01

    A semi-phenomenological approach, which combined the microscopic properties calculated by first-principles and macroscopic critical characteristics determined from empirical relations, is suggested to investigate the superconducting critical properties of the low temperature superconductor Nb3Sn with different intrinsic strain modes like uniaxial tension, shear and torsion deformations. Firstly, the microscopic properties of the electronic structure and density of state for Nb3Sn are numerically obtained by first-principles calculations using density-functional theory in the generalized gradient approximation. These are further incorporate with the macroscopic empirical relation of the unified scaling law for predicting critical parameters of the strained Nb3Sn superconductor. The superconducting critical profiles of critical temperature, magnetic field and current, in such a way, are achieved for Nb3Sn under different strains. The predictions on the critical parameters of the superconductor bulk in uniaxial tension/compression state exhibit obvious degradations and bell-shaped curves with maximum critical values at zero strain and a slight asymmetry between the tensile and compressive strains, which show quite good agreements with the experimental data. As for Nb3Sn under shear and torsion deformations, the similar degradations on critical parameters also are presented which are monotonously decreased with the applied strains. The first-principles calculations and results in this work are based on an assumption which the superconducting critical properties from the strain-induced variations in the electronic density of states. Furthermore, the modified critical surfaces of Nb3Sn, determined by the critical temperature, current and magnetic field dependence upon the applied different strains are depicted. The present study will be helpful to identify the scaling relation for the critical parameters and understanding the origin of strain sensitivity in Nb3Sn

  3. Late postnatal development of intrinsic and synaptic properties promotes fast and precise signaling in the dorsal nucleus of the lateral lemniscus.

    Science.gov (United States)

    Ammer, J J; Grothe, B; Felmy, F

    2012-02-01

    The dorsal nucleus of the lateral lemniscus (DNLL) is an auditory brain stem structure that generates a long-lasting GABAergic output, which is important for binaural processing. Despite its importance in binaural processing, little is known about the cellular physiology and the synaptic input kinetics of DNLL neurons. To assess the relevant physiological parameters of DNLL neurons, their late postnatal developmental profile was analyzed in acute brain slices of 9- to 26-day-old Mongolian gerbils. The observed developmental changes in passive membrane and action potential (AP) properties all point toward an improvement of fast and precise signal integration in these neurons. Accordingly, synaptic glutamatergic and GABAergic current kinetics accelerate with age. The changes in intrinsic and synaptic properties contribute nearly equally to reduce the latency and jitter in AP generation and thus enhance the temporal precision of DNLL neurons. Furthermore, the size of the synaptic NMDA current is developmentally downregulated. Despite this developmental reduction, DNLL neurons display an NMDA-dependent postsynaptic amplification of AP generation, known to support high firing rates, throughout this developmental period. Taken together, our findings indicate that during late postnatal development DNLL neurons are optimized for high firing rates with high temporal precision.

  4. Effects of Magnet Errors in the ILC 14 mrad Extraction Line

    Energy Technology Data Exchange (ETDEWEB)

    Toprek, Dragan; /VINCA Inst. Nucl. Sci., Belgrade; Nosochkov, Yuri; /SLAC

    2009-05-08

    The ILC baseline extraction line is designed for 14 mrad horizontal crossing angle between e{sup +} and e{sup -} colliding beams at Interaction Point (IP). The extraction optics in the Interaction Region (IR) includes a detector integrated dipole field (anti-DID) to reduce orbit perturbation caused by the detector solenoid and minimize detector background. This paper presents a study of random field and alignment errors in the extraction magnets, compensation of the induced orbit perturbation, and effects of errors on extraction beam power loss. The results are obtained for the baseline ILC energy of 500 GeV center-of-mass and three options of beam parameters.

  5. Dark matter relic density from observations of supersymmetry at the ILC

    CERN Document Server

    Lehtinen, Suvi-Leena; List, Jenny

    2016-01-01

    Supersymmetry can explain the observed dark matter relic density with a neutralino dark matter particle and a coannihilating, almost mass-degenerate sparticle. If this were the case in nature, a linear electron positron collider like the ILC could discover the two sparticles if their masses are in the kinematic reach of the collider. This contribution discusses which observations are necessary at the ILC for predicting the dark matter relic density correctly and for confirming that the observed lightest neutralino is the only kind of dark matter. We take the case of stau coannihilation as an example.

  6. New gauge boson and spin correction of top quark pair production at ILC

    Institute of Scientific and Technical Information of China (English)

    任晓燕

    2008-01-01

    Based on the SU(3)simple group model,we study the spin correction of the top quark psir produetion at the high energy linear e+e-collider (ILC) with a center-of-mass energy √s =800GeV.Our numerical results show that the gauge boson Z(H) exchange generates very small corrections to the spin correction observable in all the parameter space,which can not be detected in the future ILC experiments. [key words]SU(3)simple group model;spin correction;new gauge boson

  7. Machine-Related Backgrounds in the SiD Detector at ILC

    Energy Technology Data Exchange (ETDEWEB)

    Denisov, D.S.; Mokhov, N.V.; Striganov, S.I.; /Fermilab; Kostin, M.A.; /Michigan State U., NSCL; Tropin, I.S.; /Tomsk Polytechnic U.

    2006-08-01

    With a multi-stage collimation system and magnetic iron spoilers in the tunnel, the background particle fluxes on the ILC detector can be substantially reduced. At the same time, beam-halo interactions with collimators and protective masks in the beam delivery system create fluxes of muons and other secondary particles which can still exceed the tolerable levels for some of the ILC sub-detectors. Results of modeling of such backgrounds in comparison to those from the e{sup +}e{sup -} interactions are presented in this paper for the SiD detector.

  8. Analyzing the influence of high electrode potentials on intrinsic properties of catalyst coated membranes using impedance spectroscopy

    Science.gov (United States)

    Alink, Robert; Schüßler, Martina; Pospischil, Maximilian; Erath, Denis; Gerteisen, Dietmar

    2016-09-01

    Catalyst layers (CLs) with varying ionomer contents are produced using a stencil coating and screen printing technique. The optimum ionomer content of 31-34 wt% confirms the findings of other groups and performance is found to be independent of production technique. A new CL impedance transition line model is developed and fitted to in-situ data. The results indicate that the protonic contact resistance between CL and membrane is an important factor for the used transfer-decal process, especially for CLs with low ionomer loading. When subjected to potentials higher than 1.2 V, an increased performance is observed for low ionomer loading CLs. It is found that by applying the high potential to the electrode a significantly increased proton conductivity is counteracting and superimposing the loss of electrochemical surface area (ECSA) due to carbon corrosion. After aging, the performance of the 15 wt% CL is at the same level as the 31-34 wt% ionomer content CLs at the beginning of life, even though the ECSA is reduced due to carbon corrosion or platinum dissolution. The findings indicate that for the optimization of the ionomer loading, either the changing wetting properties or the redistribution of ionomer during lifetime have to be taken into account.

  9. Front-End Electronics in calorimetry: from LHC to ILC

    Energy Technology Data Exchange (ETDEWEB)

    De La Taille, Ch.

    2009-09-15

    This report summarizes the electronics developments for liquid argon calorimeter read-out at LHC and the development carried out in the framework of the CALICE collaboration for those of the future linear collider (ILC). It also includes chips designed for multi-anode photomultipliers (MaPMT) used in the OPERA experiment or on ATLAS luminometer, which also find applications in medical imaging. Started in the early 90's, the development for ATLAS calorimetry was extremely challenging in terms of readout speed, radiation tolerance and measurement accuracy. The high speed has required a new approach using current-sensitive preamplifiers instead of charge sensitive ones and the redefinition of noise performance in terms of ENI. The preamplifiers developed at Orsay and the monolithic shapers are described in Chapter 1, including considerations of digital filtering, which was a new technique in our field. Chapter 2 is dedicated to the calibration system, designed and built by Orsay, for which the high performance and accuracy necessitated in-depth studies. The 3. chapter closes the studies for ATLAS with a summary of the detector measurements which had to be carried out on the 200 000 channels in order to understand and model the detector and achieve everywhere the accuracy and uniformity at per-cent level. These developments for ATLAS ended in 2004, although parallel work was also carried out for the NA48 and DO calorimeters which are not detailed here. The next generation of collider will require a new generation of calorimeters, much more granular, referred to as 'imaging calorimetry' with embedded read-out electronics. The ASICs developed for this purpose in the framework of the CALICE collaboration are described in Chapter 4. They integrate all the functionalities of amplification, digitization and read-out making them complex 'System-On-Chip' circuits extremely efficient that find many other applications. A family of 3 chips reads out the

  10. Heterogeneity of Intrinsic and Synaptic Properties of Neurons in the Ventral and Dorsal Parts of the Ventral Nucleus of the Lateral Lemniscus

    Science.gov (United States)

    Caspari, Franziska; Baumann, Veronika J.; Garcia-Pino, Elisabet; Koch, Ursula

    2015-01-01

    The ventral nucleus of the lateral lemniscus (VNLL) provides a major inhibitory projection to the inferior colliculus (IC). Neurons in the VNLL respond with various firing patterns and different temporal precision to acoustic stimulation. The present study investigates the underlying intrinsic and synaptic properties of various cell types in different regions of the VNLL, using in vitro electrophysiological recordings from acute brain slices of mice and immunohistochemistry. We show that the biophysical membrane properties and excitatory input characteristics differed between dorsal and ventral VNLL neurons. Neurons in the ventral VNLL displayed an onset-type firing pattern and little hyperpolarization-activated current (Ih). Stimulation of lemniscal inputs evoked a large all-or-none excitatory response similar to Calyx of Held synapses in neurons in the lateral part of the ventral VNLL. Neurons that were located within the fiber tract of the lateral lemniscus, received several and weak excitatory input fibers. In the dorsal VNLL onset-type and sustained firing neurons were intermingled. These neurons showed large Ih and were strongly immunopositive for the hyperpolarization-activated cyclic nucleotide-gated channel 1 (HCN1) subunit. Both neuron types received several excitatory inputs that were weaker and slower compared to ventrolateral VNLL neurons. Using a mouse model that expresses channelrhodopsin under the promotor of the vesicular GABA transporter (VGAT) suggests that dorsal and ventral neurons were inhibitory since they were all depolarized by light stimulation. The diverse membrane and input properties in dorsal and ventral VNLL neurons suggest differential roles of these neurons for sound processing. PMID:26635535

  11. Intrinsic Alignments in the Illustris Simulation

    CERN Document Server

    Hilbert, Stefan; Schneider, Peter; Springel, Volker; Vogelsberger, Mark; Hernquist, Lars

    2016-01-01

    We study intrinsic alignments (IA) of galaxy image shapes within the Illustris cosmic structure formation simulations. We investigate how IA correlations depend on observable galaxy properties such as stellar mass, apparent magnitude, redshift, and photometric type, and on the employed shape measurement method. The correlations considered include the matter density-intrinsic ellipticity (mI), galaxy density-intrinsic ellipticity (dI), gravitational shear-intrinsic ellipticity (GI), and intrinsic ellipticity-intrinsic ellipticity (II) correlations. We find stronger correlations for more massive and more luminous galaxies, as well as for earlier photometric types, in agreement with observations. Moreover, shape measurement methods that down-weight the outer parts of galaxy images produce much weaker IA signals on intermediate and large scales than methods employing flat radial weights. Thus, the expected contribution of intrinsic alignments to the observed ellipticity correlation in tomographic cosmic shear sur...

  12. Single-bunch emittance dilution in the perfect ILC main linac

    Institute of Scientific and Technical Information of China (English)

    王逗; 高杰

    2011-01-01

    In the ILC (International Linear Collider) main linac, low emittance preservation is the most important issue for beam dynamics study. As the main sources of emittance dilution, the dispersive and wakefield effects were studied in this paper. The theoreti

  13. Single-bunch emittance dilution in the perfect ILC main linac

    Institute of Scientific and Technical Information of China (English)

    WANG Dou; GAO Jie

    2011-01-01

    In the ILC(International Linear Collider)main linac, low emittance preservation is the most important issue for beam dynamics study. As the main sources of emittance dilution, the dispersive and wakefield effects were studied in this paper. The theoretical calculations and numerical simulations of these two effects on single-bunch emittance dilution, without any misalignment errors, are presented in detail.

  14. A novel IL-10-producing innate lymphoid cells (ILC10) in a contact hypersensitivity mouse model

    Science.gov (United States)

    Kim, Hyuk Soon; Jang, Jong-Hwa; Lee, Min Bum; Jung, In Duk; Park, Yeong-Min; Kim, Young Mi; Choi, Wahn Soo

    2016-01-01

    The immunoregulatory cytokine Interleukin 10 (IL-10) protein is produced by various cells during the course of inflammatory disorders. Mainly, it downregulates pro-inflammatory cytokines, antigen presentation, and helper T cell activation. In this study, we show that the ratio of IL-10-producing cells was significantly increased in lineage negative (i.e., not T, B, or leukocyte cell lineages) cells than in lineage positive cells in lymphoid and peripheral tissues. We further observed that IL-10-producing innate lymphoid cells (ILCs), here called firstly ILC10, were increased in number in oxazolone-induced contact hypersensitivity (CHS) mice. In detail, IL-10-producing lineage negative cells were elevated in the axillary, inguinal lymph node, and ear tissues of CHS mice. Notably, the cells expressed classical ILC marker proteins such as CD45, CD127, and Sca-1. Altogether, our findings suggest for the first time that ILC10s are present in various physiological settings and could be involved in numerous immune responses as regulatory cells. [BMB Reports 2016; 49(5): 293-296] PMID:26949018

  15. The POWHEG method applied to top pair production and decays at the ILC

    CERN Document Server

    Latunde-Dada, Oluseyi

    2008-01-01

    We study the effects of gluon radiation in top pair production and their decays for e+e- annihilation at the ILC. To achieve this we apply the POWHEG method and interface our results to the Monte Carlo event generator Herwig++. We consider a center-of-mass energy of 500GeV and compare decay correlations and bottom quark distributions before hadronization.

  16. Physics Case for the ILC Project: Perspective from Beyond the Standard Model

    CERN Document Server

    Baer, Howard; List, Jenny; Nojiri, Mihoko M; Perelstein, Maxim; Pierce, Aaron; Porod, Werner; Tanabe, Tomohiko

    2013-01-01

    The International Linear Collider (ILC) has recently proven its technical maturity with the publication of a Technical Design Report, and there is a strong interest in Japan to host such a machine. We summarize key aspects of the Beyond the Standard Model physics case for the ILC in this contribution to the US High Energy Physics strategy process. On top of the strong guaranteed physics case in the detailed exploration of the recently discovered Higgs boson, the top quark and electroweak precision measurements, the ILC will offer unique opportunities which are complementary to the LHC program of the next decade. Many of these opportunities have connections to the Cosmic and Intensity Frontiers, which we comment on in detail. We illustrate the general picture with examples of how our world could turn out to be and what the ILC would contribute in these cases, with an emphasis on value-added beyond the LHC. These comprise examples from Supersymmetry including light Higgsinos, a comprehensive bottom-up coverage ...

  17. International Linear Collider Reference Design Report Volume 2: PHYSICS AT THE ILC

    CERN Document Server

    Aarons, Gerald; Abernathy, Jason; Ablikim, Medina; Abramowicz, Halina; Adey, David; Adloff, Catherine; Adolphsen, Chris; Afanaciev, Konstantin; Agapov, Ilya; Ahn, Jung-Keun; Aihara, Hiroaki; Akemoto, Mitsuo; del Carmen Alabau, Maria; Albert, Justin; Albrecht, Hartwig; Albrecht, Michael; Alesini, David; Alexander, Gideon; Alexander, Jim; Allison, Wade; Amann, John; Amirikas, Ramila; An, Qi; Anami, Shozo; Ananthanarayan, B.; Anderson, Terry; Andricek, Ladislav; Anduze, Marc; Anerella, Michael; Anfimov, Nikolai; Angal-Kalinin, Deepa; Antipov, Sergei; Antoine, Claire; Aoki, Mayumi; Aoza, Atsushi; Aplin, Steve; Appleby, Rob; Arai, Yasuo; Araki, Sakae; Arkan, Tug; Arnold, Ned; Arnold, Ray; Arnowitt, Richard; Artru, Xavier; Arya, Kunal; Aryshev, Alexander; Asakawa, Eri; Asiri, Fred; Asner, David; Atac, Muzaffer; Atoian, Grigor; Attie, David; Augustin, Jean-Eudes; Augustine, David B.; Ayres, Bradley; Aziz, Tariq; Baars, Derek; Badaud, Frederique; Baddams, Nigel; Bagger, Jonathan; Bai, Sha; Bailey, David; Bailey, Ian R.; Baker, David; Balalykin, Nikolai I.; Balbuena, Juan Pablo; Baldy, Jean-Luc; Ball, Markus; Ball, Maurice; Ballestrero, Alessandro; Ballin, Jamie; Baltay, Charles; Bambade, Philip; Ban, Syuichi; Band, Henry; Bane, Karl; Banerjee, Bakul; Barbanotti, Serena; Barbareschi, Daniele; Barbaro-Galtieri, Angela; Barber, Desmond P.; Barbi, Mauricio; Bardin, Dmitri Y.; Barish, Barry; Barklow, Timothy L.; Barlow, Roger; Barnes, Virgil E.; Barone, Maura; Bartels, Christoph; Bartsch, Valeria; Basu, Rahul; Battaglia, Marco; Batygin, Yuri; Baudot, Jerome; Baur, Ulrich; Baynham, D.Elwyn; Beard, Carl; Bebek, Chris; Bechtle, Philip; Becker, Ulrich J.; Bedeschi, Franco; Bedjidian, Marc; Behera, Prafulla; Behnke, Ties; Bellantoni, Leo; Bellerive, Alain; Bellomo, Paul; Bentson, Lynn D.; Benyamna, Mustapha; Bergauer, Thomas; Berger, Edmond; Bergholz, Matthias; Beri, Suman; Berndt, Martin; Bernreuther, Werner; Bertolini, Alessandro; Besancon, Marc; Besson, Auguste; Beteille, Andre; Bettoni, Simona; Beyer, Michael; Bhandari, R.K.; Bharadwaj, Vinod; Bhatnagar, Vipin; Bhattacharya, Satyaki; Bhattacharyya, Gautam; Bhattacherjee, Biplob; Bhuyan, Ruchika; Bi, Xiao-Jun; Biagini, Marica; Bialowons, Wilhelm; Biebel, Otmar; Bieler, Thomas; Bierwagen, John; Birch, Alison; Bisset, Mike; Biswal, S.S.; Blackmore, Victoria; Blair, Grahame; Blanchard, Guillaume; Blazey, Gerald; Blue, Andrew; Blumlein, Johannes; Boffo, Christian; Boiko, V.I.; Boisvert, Veronique; Bondarchuk, Eduard N.; Boni, Roberto; Bonvicini, Giovanni; Boogert, Stewart; Boonekamp, Maarten; Boorman, Gary; Borras, Kerstin; Bortoletto, Daniela; Bosco, Alessio; Bosio, Carlo; Bosland, Pierre; Bosotti, Angelo; Boudry, Vincent; Boumediene, Djamel-Eddine; Bouquet, Bernard; Bourov, Serguei; Bowden, Gordon; Bower, Gary; Boyarski, Adam; Bozovic-Jelisavcic, Ivanka; Bozzi, Concezio; Brachmann, Axel; Bradshaw, Tom W.; Brandt, Andrew; Brasser, Hans Peter; Brau, Benjamin; Brau, James E.; Breidenbach, Martin; Bricker, Steve; Brient, Jean-Claude; Brock, Ian; Brodsky, Stanley; Brooksby, Craig; Broome, Timothy A.; Brown, David; Brown, David; Brownell, James H.; Bruchon, Melanie; Brueck, Heiner; Brummitt, Amanda J.; Brun, Nicole; Buchholz, Peter; Budagov, Yulian A.; Bulgheroni, Antonio; Bulyak, Eugene; Bungau, Adriana; Burger, Jochen; Burke, Dan; Burkhart, Craig; Burrows, Philip; Burt, Graeme; Burton, David; Busser, Karsten; Butler, John; Butterworth, Jonathan; Buzulutskov, Alexei; Cabruja, Enric; Caccia, Massimo; Cai, Yunhai; Calcaterra, Alessandro; Caliier, Stephane; Camporesi, Tiziano; Cao, Jun-Jie; Cao, J.S.; Capatina, Ofelia; Cappellini, Chiara; Carcagno, Ruben; Carena, Marcela; Carloganu, Cristina; Carosi, Roberto; Carr, F.Stephen; Carrion, Francisco; Carter, Harry F.; Carter, John; Carwardine, John; Cassel, Richard; Cassell, Ronald; Cavallari, Giorgio; Cavallo, Emanuela; Cembranos, Jose A.R.; Chakraborty, Dhiman; Chandez, Frederic; Charles, Matthew; Chase, Brian; Chattopadhyay, Subhasis; Chauveau, Jacques; Chefdeville, Maximilien; Chehab, Robert; Chel, Stephane; Chelkov, Georgy; Chen, Chiping; Chen, He Sheng; Chen, Huai Bi; Chen, Jia Er; Chen, Sen Yu; Chen, Shaomin; Chen, Shenjian; Chen, Xun; Chen, Yuan Bo; Cheng, Jian; Chevallier, M.; Chi, Yun Long; Chickering, William; Cho, Gi-Chol; Cho, Moo-Hyun; Choi, Jin-Hyuk; Choi, Jong Bum; Choi, Seong Youl; Choi, Young-Il; Choudhary, Brajesh; Choudhury, Debajyoti; Choudhury, S.Rai; Christian, David; Christian, Glenn; Christophe, Grojean; Chung, Jin-Hyuk; Church, Mike; Ciborowski, Jacek; Cihangir, Selcuk; Ciovati, Gianluigi; Clarke, Christine; Clarke, Don G.; Clarke, James A.

    2007-01-01

    This article reviews the physics case for the ILC. Baseline running at 500 GeV as well as possible upgrades and options are discussed. The opportunities on Standard Model physics, Higgs physics, Supersymmetry and alternative theories beyond the Standard Model are described.

  18. High Resolution Cavity BPM for ILC Final Focal System (IP-BPM)

    CERN Document Server

    Nakamura, Tomoya; Inoue, Yoichi; Tauchi, Toshiaki; Urakawa, Junji; Sanuki, Tomoyuki; Komamiya, Sachio

    2007-01-01

    IP-BPM (Interaction Point Beam Position Monitor) is an ultra high resolution cavity BPM to be used at ATF2, a test facility for ILC final focus system. Control of beam position in 2 nm precision is required for ATF2. Beam tests at ATF extraction line proved a 8.7 nm position resolution.

  19. Lepton flavor violating Higgs boson decay {\\boldsymbol{h}} \\rightarrow \\mu \\tau at the ILC

    Science.gov (United States)

    Chakraborty, Indrani; Datta, Amitava; Kundu, Anirban

    2016-12-01

    We study the possible reach of the proposed International Linear Collider (ILC) in exploring the lepton flavour violating (LFV) Higgs boson decay h\\to μ τ . Two generic types of models are investigated, both involving an extended scalar sector. For the first type, the rest of the scalars are heavy and beyond the reach of ILC, but the LFV decay occurs through a tiny admixture of the Standard Model (SM) doublet with heavy degrees of freedom. In the second class, which is more constrained from the existing data, the SM Higgs boson does not have any LFV decay but there are other scalars degenerate with it that give rise to the LFV signal. We show that the ILC can pin down the branching fraction of h\\to μ τ , and hence the effective LFV Yukawa coupling, to a very small value, due to the fact that there are signal channels with unlike flavour leptons but no missing energy. It turns out that the low-energy options of the ILC, namely, \\sqrt{s}=250 or 500 GeV, are better for investigating such channels, and the option of beam polarization helps too. At least an order of magnitude improvement is envisaged over the existing limits, and the effective LFV Yukawa coupling can be probed at the level of 10-4.

  20. Cryogenic system configuration for the International Linear Collider (ILC) at mountainous site

    Science.gov (United States)

    Nakai, H.; Okamura, T.; Delikaris, D.; Peterson, T.; Yamamoto, A.

    2017-02-01

    The International Linear Collider (ILC) plans to make use of ten cryoplants for its main linacs, each providing 19 kW at 4.5 K equivalent and among of it 3.6 kW at 2 K. Each cryoplant will consist of various cryogenic components such as a 4.5 K refrigerator cold box, a 2 K refrigerator cold box, and helium compressors and so on. In the technical design report (TDR) of the ILC, due to the mountainous topology, almost all cryogenic components would be installed in underground cryogenic caverns next to the main linac tunnels and only cooling towers on surface area. However, we would like to find a more effective and sophisticated configuration of the cryoplant components (cryogenic configuration). Under several constraints of technical, geographical, and environmental points of view, the cryogenic configuration should be considered carefully to satisfy such various conditions. After discussions on this topic conducted at various workshops and conferences, an updated cryogenic configuration is suggested. The proposed updated configuration may affect the total construction cost of the ILC and the entire structure of the ILC conventional facilities. The updated cryogenic configuration is presented and the on-going discussions with the conventional facilities and siting (CFS) colleagues for further improvement of the cryogenic configuration is introduced.

  1. Testing the supersymmetric QCD Yukawa coupling in a combined LHC/ILC analysis

    Indian Academy of Sciences (India)

    A Freitas; P Z Skands

    2007-11-01

    In order to establish supersymmetry (SUSY) at future colliders, the identity of gauge couplings and the corresponding Yukawa couplings between gauginos, sfermions and fermions needs to be verified. A first phenomenological study for determining the Yukawa coupling of the SUSY-QCD sector is presented here, using a method which combines information from LHC and ILC.

  2. The unique axon trajectory of the accessory nerve is determined by intrinsic properties of the neural tube in the avian embryo.

    Science.gov (United States)

    Bai, Zhongtian; Pu, Qin; Haque, Ziaul; Wang, Jianlin; Huang, Ruijin

    2016-05-01

    The accessory nerve is a cranial nerve, composed of only motor axons, which control neck muscles. Its axons ascend many segments along the lateral surface of the cervical spinal cord and hindbrain. At the level of the first somite, they pass ventrally through the somitic mesoderm into the periphery. The factors governing the unique root trajectory are unknown. Ablation experiments at the accessory nerve outlet points have shown that somites do not regulate the trajectory of the accessory nerve fibres. Factors from the neural tube that may control the longitudinal pathfinding of the accessory nerve fibres were tested by heterotopic transplantations of an occipital neural tube to the cervical and thoracic level. These transplantations resulted in a typical accessory nerve trajectory in the cervical and thoracic spinal cord. In contrast, cervical neural tube grafts were unable to give rise to the typical accessory nerve root pattern when transplanted to occipital level. Our results show that the formation of the unique axon root pattern of the accessory nerve is an intrinsic property of the neural tube.

  3. Ferromagnetic resonance and intrinsic properties of La{sub 0.67}Ba{sub 0.33}MnO{sub {ital z}}

    Energy Technology Data Exchange (ETDEWEB)

    Lofland, S.E.; Bhagat, S.M.; Ju, H.L.; Xiong, G.C.; Venkatesan, T.; Greene, R.L. [Department of Physics, University of Maryland, College Park, Maryland 20742-4111 (United States); Tyagi, S. [Department of Physics, Drexel University, Philadelphia, Pennsylvania 19104 (United States)

    1996-04-01

    Systematic magnetization and ferromagnetic resonance (FMR) measurements have been performed on thin-film samples of La{sub 0.67}Ba{sub 0.33}MnO{sub {ital z}} ({ital T}{sub {ital C}}{approximately}340 K). It is found from the FMR data that as- grown films show broad lines whose width {Gamma} increases to nearly 1 kOe as {ital T} reduced to 77 K. The increase roughly follows the increase in the magnetization suggesting magnetic inhomogeneity as the main cause for the rise in {Gamma}. However, when films were properly annealed in O{sub 2}, we obtained narrow lines ({Gamma}{approximately}200 Oe at 10 GHz). {Gamma} was effectively independent of temperature and linearly dependent upon microwave frequency, both of which are strong signs that, we have succeeded in obtaining a {ital uniform}, {ital homogeneous} {ital manganite} sample. Having gotten a uniform material, we have measured the intrinsic properties of this system. {copyright} {ital 1996 American Institute of Physics.}

  4. Three-Dimensional Simulations of the Electrothermal and Terahertz Emission Properties of Bi2 Sr2 CaCu2 O8 Intrinsic Josephson Junction Stacks

    Science.gov (United States)

    Rudau, F.; Wieland, R.; Langer, J.; Zhou, X. J.; Ji, M.; Kinev, N.; Hao, L. Y.; Huang, Y.; Li, J.; Wu, P. H.; Hatano, T.; Koshelets, V. P.; Wang, H. B.; Koelle, D.; Kleiner, R.

    2016-04-01

    We use 2D coupled sine-Gordon equations combined with 3D heat diffusion equations to numerically investigate the thermal and electromagnetic properties of a 250 ×70 μ m2 intrinsic Josephson junction stack. The 700 junctions are grouped to 20 segments; we assume that in a segment all junctions behave identically. At large input power, a hot spot forms in the stack. Resonant electromagnetic modes oscillating either along the length [(0, n ) modes] or the width [(m , 0) modes] of the stack or having a more complex structure can be excited both with and without a hot spot. At fixed bath temperature and bias current, several cavity modes can coexist in the absence of a magnetic field. The (1, 0) mode considered to be the most favorable mode for terahertz emission can be stabilized by applying a small magnetic field along the length of the stack. A strong field-induced enhancement of the emission power is also found in experiment for an applied field around 5.9 mT.

  5. The Persistence of Asthma requires Multiple Feedback Circuits Involving ILC2 and IL33

    Science.gov (United States)

    Christianson, Christina A.; Goplen, Nicholas P.; Zafar, Iram; Irvin, Chaoyu; Good, James T.; Rollins, Donald R.; Gorentla, Balachandra; Liu, Weimin; Gorska, Magdalena M.; Chu, HongWei; Martin, Richard J.; Alam, Rafeul

    2015-01-01

    Background Asthma in the mouse model spontaneously resolves after cessation of allergen exposure. We developed a mouse model where asthma features persisted for 6 months after cessation of allergen exposure. Objective To elucidate factors contributing to the persistence of asthma. Methods We utilized a combination of immunologic, genetic, microarray and pharmacologic approaches to dissect the mechanism of persistence of asthma. Results Elimination of T cells though antibody-mediated depletion or lethal irradiation and transplantation of Rag1−/− bone marrow in mice with chronic asthma resulted in resolution of airway inflammation but not airway hyperreactivity or remodeling. Elimination of T cells and ILC2 through lethal irradiation and transplantation of Rag2−/−γc−/− bone marrow or blockade of IL33 resulted in resolution of airway inflammation and hyperreactivity. Persistence of asthma required multiple interconnected feedback and feed forward circuits between ILC2 and epithelial cells. Epithelial IL33 induced ILC2, a rich source of IL13. The latter directly induced epithelial IL33 establishing a positive feedback circuit. IL33 auto-induced, generating another feedback circuit. IL13 upregulated IL33 receptors and facilitated IL33 auto-induction, thus establishing a feed forward circuit. Elimination of any component of these circuits resulted in resolution of chronic asthma. In agreement with the foregoing, IL33 and ILC2 were increased in the airways from asthmatic patients. IL33 correlated with disease severity. Conclusions We present a critical network of feedback and feed forward interactions between epithelial cells and ILC2 involved in maintaining chronic asthma. Although T cells contributed to the severity of chronic asthma they were redundant in maintaining airway hyperreactivity and remodeling. PMID:25617223

  6. Intrinsically Disordered Energy Landscapes

    Science.gov (United States)

    Chebaro, Yassmine; Ballard, Andrew J.; Chakraborty, Debayan; Wales, David J.

    2015-05-01

    Analysis of an intrinsically disordered protein (IDP) reveals an underlying multifunnel structure for the energy landscape. We suggest that such ‘intrinsically disordered’ landscapes, with a number of very different competing low-energy structures, are likely to characterise IDPs, and provide a useful way to address their properties. In particular, IDPs are present in many cellular protein interaction networks, and several questions arise regarding how they bind to partners. Are conformations resembling the bound structure selected for binding, or does further folding occur on binding the partner in a induced-fit fashion? We focus on the p53 upregulated modulator of apoptosis (PUMA) protein, which adopts an -helical conformation when bound to its partner, and is involved in the activation of apoptosis. Recent experimental evidence shows that folding is not necessary for binding, and supports an induced-fit mechanism. Using a variety of computational approaches we deduce the molecular mechanism behind the instability of the PUMA peptide as a helix in isolation. We find significant barriers between partially folded states and the helix. Our results show that the favoured conformations are molten-globule like, stabilised by charged and hydrophobic contacts, with structures resembling the bound state relatively unpopulated in equilibrium.

  7. Beam Polarization at the ILC: the Physics Impact and the Accelerator Solutions

    Energy Technology Data Exchange (ETDEWEB)

    Aurand, B.; /Bonn U.; Bailey, I.; /Liverpool U.; Bartels, C.; /DESY /DESY, Zeuthen; Brachmann, A.; /SLAC; Clarke, J.; /Daresbury; Hartin, A.; /DESY /DESY, Zeuthen /Oxford U., JAI; Hauptman, J.; /Iowa State U.; Helebrant, C.; /DESY /DESY, Zeuthen; Hesselbach, S.; /Durham U., IPPP; Kafer, D.; List, J.; /DESY /DESY, Zeuthen; Lorenzon, W.; /Michigan U.; Marchesini, I.; Monig, Klaus; /DESY /DESY, Zeuthen; Moffeit, K.C.; /SLAC; Moortgat-Pick, G.; /Durham U., IPPP; Riemann, S.; Schalicke, A.; Schuler, P.; /DESY /DESY, Zeuthen; Starovoitov, P.; /Minsk, NCPHEP; Ushakov, A.; /DESY /DESY, Zeuthen /Bonn U. /SLAC

    2011-11-23

    In this contribution accelerator solutions for polarized beams and their impact on physics measurements are discussed. Focus are physics requirements for precision polarimetry near the interaction point and their realization with polarized sources. Based on the ILC baseline programme as described in the Reference Design Report (RDR), recent developments are discussed and evaluated taking into account physics runs at beam energies between 100 GeV and 250 GeV, as well as calibration runs on the Z-pole and options as the 1TeV upgrade and GigaZ. The studies, talks and discussions presented at this conference demonstrated that beam polarization and its measurement are crucial for the physics success of any future linear collider. To achieve the required precision it is absolutely decisive to employ multiple devices for testing and controlling the systematic uncertainties of each polarimeter. The polarimetry methods for the ILC are complementary: with the upstream polarimeter the measurements are performed in a clean environment, they are fast and allow to monitor time-dependent variations of polarization. The polarimeter downstream the IP will measure the disrupted beam resulting in high background and much lower statistics, but it allows access to the depolarization at the IP. Cross checks between the polarimeter results give redundancy and inter-calibration which is essential for high precision measurements. Current plans and issues for polarimeters and also energy spectrometers in the Beam Delivery System of the ILC are summarized in reference [28]. The ILC baseline design allows already from the beginning the operation with polarized electrons and polarized positrons provided the spin rotation and the fast helicity reversal for positrons will be implemented. A reversal of the positron helicity significantly slower than that of electrons is not recommended to not compromise the precision and hence the success of the ILC. Recently to use calibration data at the Z

  8. 国际未来直线对撞机(ILC)阻尼环Lattice设计%An Alternative Lattice Design for ILC Damping Ring

    Institute of Scientific and Technical Information of China (English)

    孙一鹏; 高杰; 郭之虞

    2006-01-01

    The ILC damping rings should provide beams with very low natural emittances for the linear collider to reach the required luminosity, and at the same time, the damping rings also need to have a large acceptance to ensure good injection efficiency for high emittance, high energy spread beam from the positron source. Meeting the above requirements is a real challenge for the ILC damping ring lattice design. In order to reduce the cost for ILC damping rings, an alternative lattice different from the baseline configuration design has been done with modified FODO cells, and the total quadrupole number has been reduced by half. The new lattice has been optimised to have good dynamic apertures.%为了使国际未来直线对撞机达到高的亮度,对撞机的阻尼环必须要有很小的自然发射度.同时,阻尼环要有很大的接收度来接受来自正电子注入系统的大能散、大发射度的正电子束团.对于磁聚焦结构的设计来说,同时达到以上要求是一件很有挑战性的工作.为了降低ILC阻尼环的造价采用修正的FODO结构设计了可以满足ILC要求的阻尼环备用Lattice,并使四极磁铁的数量比起ILC阻尼环BCD设计减少了一半.

  9. Evaluation and Compensation of Detector Solenoid Effects on Disrupted Beam in the ILC 14 mrad Extraction Line

    Energy Technology Data Exchange (ETDEWEB)

    Toprek, Dragan; /VINCA Inst. Nucl. Sci., Belgrade; Nosochkov, Yuri; /SLAC

    2008-12-18

    This paper presents calculations of detector solenoid effects on disrupted primary beam in the ILC 14 mrad extraction line. Particle tracking simulations are performed for evaluation of primary beam loss along the line as well as of beam distribution and polarization at Compton Interaction Point. The calculations are done both without and with solenoid compensation. The results are obtained for the baseline ILC energy of 500 GeV center-of-mass and three options of beam parameters.

  10. Design of Pre-Dumping Ring Spin Rotator with a Possibility of Helicity Switching for Polarized Positrons at the ILC

    CERN Document Server

    Malysheva, L I; Hartin, A; Kovalenko, V; List, B; Moortgat-Pick, G A; Riemann, S; Staufenbiel, F; Ushakov, A; Walker, N J

    2016-01-01

    The use of polarized beams enhance the possibility of the precision measurements at the International Linear Collider (ILC). In order to preserve the degree of polarization during beam transport spin rotators are included in the current TDR ILC Lattice. In this report some advantages of using a combined spin rotator/spin flipper are discussed. A few possible lattice designs of spin flipper developed at DESY in 2012 are presented.

  11. Intrinsic acid-base properties of a hexa-2'-deoxynucleoside pentaphosphate, d(ApGpGpCpCpT): neighboring effects and isomeric equilibria.

    Science.gov (United States)

    Domínguez-Martín, Alicia; Johannsen, Silke; Sigel, Astrid; Operschall, Bert P; Song, Bin; Sigel, Helmut; Okruszek, Andrzej; González-Pérez, Josefa María; Niclós-Gutiérrez, Juan; Sigel, Roland K O

    2013-06-17

    The intrinsic acid-base properties of the hexa-2'-deoxynucleoside pentaphosphate, d(ApGpGpCpCpT) [=(A1∙G2∙G3∙C4∙C5∙T6)=(HNPP)⁵⁻] have been determined by ¹H NMR shift experiments. The pKa values of the individual sites of the adenosine (A), guanosine (G), cytidine (C), and thymidine (T) residues were measured in water under single-strand conditions (i.e., 10% D₂O, 47 °C, I=0.1 M, NaClO₄). These results quantify the release of H⁺ from the two (N7)H⁺ (G∙G), the two (N3)H⁺ (C∙C), and the (N1)H⁺ (A) units, as well as from the two (N1)H (G∙G) and the (N3)H (T) sites. Based on measurements with 2'-deoxynucleosides at 25 °C and 47 °C, they were transferred to pKa values valid in water at 25 °C and I=0.1 M. Intramolecular stacks between the nucleobases A1 and G2 as well as most likely also between G2 and G3 are formed. For HNPP three pKa clusters occur, that is those encompassing the pKa values of 2.44, 2.97, and 3.71 of G2(N7)H⁺, G3(N7)H⁺, and A1(N1)H⁺, respectively, with overlapping buffer regions. The tautomer populations were estimated, giving for the release of a single proton from five-fold protonated H₅(HNPP)(±) , the tautomers (G2)N7, (G3)N7, and (A1)N1 with formation degrees of about 74, 22, and 4%, respectively. Tautomer distributions reveal pathways for proton-donating as well as for proton-accepting reactions both being expected to be fast and to occur practically at no "cost". The eight pKa values for H₅(HNPP)(±) are compared with data for nucleosides and nucleotides, revealing that the nucleoside residues are in part affected very differently by their neighbors. In addition, the intrinsic acidity constants for the RNA derivative r(A1∙G2∙G3∙C4∙C5∙U6), where U=uridine, were calculated. Finally, the effect of metal ions on the pKa values of nucleobase sites is briefly discussed because in this way deprotonation reactions can easily be shifted to the physiological pH range.

  12. Observations and predictions at CesrTA, and outlook for ILC

    CERN Document Server

    Dugan, G; Butler, K; Chu, J; Crittenden, J; Forster, M; Kreinick, D; Meller, R; Palmer, M; Ramirez, G; Rendina, M; Rider, N; Sonnad, K; Williams, H; Campbell, R; Holtzapple, R; Randazzo, M; Flanagan, J; Ohmi, K; Furman, M; Venturini, M; Pivi, M

    2013-01-01

    In this paper, we will describe some of the recent experimental measurements [1, 2, 3] performed at CESRTA [4], and the supporting simulations, which probe the interaction of the electron cloud with the stored beam. These experiments have been done over a wide range of beam energies, emittances, bunch currents, and fill patterns, to gather sufficient information to be able to fully characterize the beam-electron-cloud interaction and validate the simulation programs. The range of beam conditions is chosen to be as close as possible to those of the ILC damping ring, so that the validated simulation programs can be used to predict the performance of these rings with regard to electroncloud- related phenomena. Using the new simulation code Synrad3D to simulate the synchrotron radiation environment, a vacuum chamber design has been developed for the ILC damping ring which achieves the required level of photoelectron suppression. To determine the expected electron cloud density in the ring, EC buildup simulations ...

  13. The ILC P2 Marx and Application of the Marx Topology to Future Accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Kemp, M.A.; Benwell, A.; Burkhart, C.; Hugyik, J.; Larsen, R.; Macken, K.; MacNair, D.; Nguyen, M.; Olsen, J.; /SLAC

    2011-08-19

    The SLAC P2 Marx is under development as the linac klystron modulator for the ILC. This modulator builds upon the success of the P1 Marx, which is currently undergoing lifetime evaluation. While the SLAC P2 Marx's (henceforth, 'P2 Marx') target application is the ILC, characteristics of the Marx topology make it equally well-suited for operation at different parameter ranges; for example, increased pulse repetition frequency, increased output current, longer pulse width, etc. Marx parameters such as the number of cells, cell capacitance, and component selection can be optimized for the application. This paper provides an overview of the P2 Marx development. In addition, the scalability of the Marx topology to other long-pulse parameter ranges is discussed.

  14. Monte-Carlo-based studies of a polarized positron source for International Linear Collider (ILC)

    Science.gov (United States)

    Dollan, Ralph; Laihem, Karim; Schälicke, Andreas

    2006-04-01

    The full exploitation of the physics potential of an International Linear Collider (ILC) requires the development of a polarized positron beam. New concepts of polarized positron sources are based on the development of circularly polarized photon sources. The polarized photons create electron-positron pairs in a thin target and transfer their polarization state to the outgoing leptons. To achieve a high level of positron polarization the understanding of the production mechanisms in the target is crucial. Therefore, a general framework for the simulation of polarized processes with GEANT4 is under development. In this contribution the current status of the project and its application to a study of the positron production process for the ILC is presented.

  15. Neutralino relic density from ILC measurements in the CP-violating MSSM

    Science.gov (United States)

    Bélanger, G.; Kittel, O.; Kraml, S.; Martyn, H.-U.; Pukhov, A.

    2008-07-01

    We discuss ILC measurements for a specific MSSM scenario with CP phases, where the lightest neutralino is a good candidate for dark matter, annihilating efficiently through t-channel exchange of light staus. These prospective (CP-even) ILC measurements are then used to fit the underlying model parameters. A collider prediction of the relic density of the neutralino from this fit gives 0.116<Ωh2<0.19 at 95% C.L. CP-odd observables, while being a direct signal of CP violation, do not help in further constraining Ωh2. The interplay with (in)direct detection of dark matter and with measurements of electric dipole moments is also discussed. Finally we comment on collider measurements at higher energies for refining the prediction of Ωh2.

  16. Higgs Pair Production at the LHC and ILC from general potential

    CERN Document Server

    Haba, Naoyuki; Mimura, Yukihiro; Tsedenbaljir, Enkhbat

    2013-01-01

    Higgs cubic coupling plays a crucial role to probe an origin of electroweak symmetry breaking. It is expected that the cubic coupling is measured by Higgs pair production at the LHC and ILC, and the deviations from the standard model can be extracted from the Higgs pair production process, and those can give us a hint of new physics beyond the standard model. We consider a general potential that achieves the suitable electroweak symmetry breaking. As one of the interesting models, we suggest a non-perturbative Higgs model in which a run-away type of potential is used. In the model, the cross sections of pair production at the LHC is enlarged compared to the standard model. We also study the Higgs pair production induced by a non-canonical kinetic term of Higgs fields which will be important to search the pair-production at the ILC.

  17. One loop effects of natural SUSY in third generation fermion production at the ILC

    CERN Document Server

    Kouda, Yusaku; Kurihara, Yoshimasa; Ishikawa, Tadashi; Jimbo, Masato; Kato, Kiyoshi; Kuroda, Masaaki

    2016-01-01

    We investigate the 1-loop effects of supersymmetric particles on the third-generation fermion-pair production at the ILC within the framework of the Minimal Supersymmetric Standard Model. Three sets of the SUSY parameters are proposed which are consistent with the observed Higgs mass, the muon $g$-$2$, the Dark Matter abundance, etc. We discuss on the possibility of discovering the signals consistent with SUSY as well as of experimentally distinguishing the proposed sets of SUSY parameters.

  18. Trajectory Tracking Control for a GMM Actuator Based on a Heuristic ILC Method

    Institute of Scientific and Technical Information of China (English)

    SONG Zhao-qing; ZHOU Shao-lei; SHI Xian-jun

    2006-01-01

    A heuristic iterative learning control (ILC) method is presented and applied to the trajectory tracking control of a giant magnetostrictive material (GMM) actuator. A GMM actuator is used as experimental equipment for micro-displacement trajectory tracking control. The advantage of the presented approach lies in quitting the model of the GMM actuator. The experimental results attest to the high efficiency of the presented method for the micro-displacement trajectory tracking control.

  19. Study of top quark pair production near threshold at the ILC

    CERN Document Server

    Horiguchi, Tomohiro; Suehara, Taikan; Fujii, Keisuke; Sumino, Yukinari; Kiyo, Yuichiro; Yamamoto, Hitoshi

    2013-01-01

    We report on a study of top pair production at the International Linear Collider (ILC) around center of mass energy (E$_{\\rm CM}$) = 350 GeV using an ILD detector simulator based on the Detailed Baseline Design (DBD) configuration. Here we will report on a result of 6-Jet final state, $t\\ bar{t} \\rightarrow bWbW \\rightarrow bqqbqq$. A result for the 4-Jet final state, $t\\ bar{t} \\rightarrow bWbW \\rightarrow bqqbl\

  20. Towards a precise measurement of the top quark Yukawa coupling at the ILC

    Energy Technology Data Exchange (ETDEWEB)

    Juste, A.

    2005-12-01

    A precise measurement of the top quark Yukawa coupling is of great importance, since it may shed light on the mechanism of EWSB. We study the prospects of such measurement during the first phase of the ILC at {radical}s = 500 GeV, focusing in particular on recent theoretical developments as well as the potential benefits of beam polarization. It is shown that both yield improvements that could possibly lead to a measurement competitive with the LHC.

  1. Applying the POWHEG method to top pair production and decays at the ILC

    CERN Document Server

    Latunde-Dada, Oluseyi

    2008-01-01

    We study the effects of gluon radiation in top pair production and their decays for e+e- annihilation at the ILC. To achieve this we apply the POWHEG method and interface our results to the Monte Carlo event generator Herwig++. We consider a center-of-mass energy of \\sqrt{s}=500 GeV and compare decay correlations and bottom quark and anti-quark distributions before hadronization.

  2. Monte Carlo based studies of a polarized positron source for international linear collider (ILC).

    OpenAIRE

    Schälicke, A.; Dollan, R.; Laihem, K.

    2006-01-01

    The full exploitation of the physics potential of an International Linear Collider (ILC) requires the development of a polarized positron beam. New concepts of polarized positron sources are based on the development of circularly polarized photon sources. The polarized photons create electron-positron pairs in a thin target and transfer their polarization state to the outgoing leptons. To achieve a high level of positron polarization the understanding of the production mechanisms in the targe...

  3. Determination of new electroweak parameters at the ILC. Sensitivity to new physics

    Energy Technology Data Exchange (ETDEWEB)

    Beyer, M.; Schmidt, E.; Schroeder, H. [Rostock Univ. (Germany). Inst. fuer Physik; Kilian, W. [Siegen Univ. (Gesamthochschule) (Germany). Fach Physik]|[Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Krstonosic, P.; Reuter, J. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Moenig, K. [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany)

    2006-04-15

    We present a study of the sensitivity of an International Linear Collider (ILC) to electroweak parameters in the absence of a light Higgs boson. In particular, we consider those parameters that have been inaccessible at previous colliders, quartic gauge couplings. Within a generic effective-field theory context we analyze all processes that contain quasi-elastic weak-boson scattering, using complete six-fermion matrix elements in unweighted event samples, fast simulation of the ILC detector, and a multidimensional parameter fit of the set of anomalous couplings. The analysis does not rely on simplifying assumptions such as custodial symmetry or approximations such as the equivalence theorem. We supplement this by a similar new study of triple weak-boson production, which is sensitive to the same set of anomalous couplings. Including the known results on triple gauge couplings and oblique corrections, we thus quantitatively determine the indirect sensitivity of the ILC to new physics in the electroweak symmetry-breaking sector, conveniently parameterized by real or fictitious resonances in each accessible spin/isospin channel. (Orig.)

  4. Measurement of Higgs couplings and self-coupling at the ILC

    CERN Document Server

    Tian, Junping

    2013-01-01

    In the Standard Model (SM) the couplings of the Higgs boson to SM particles and itself (self-couplings) are uniquely specified once the masses of the particles in question as well as the Higgs boson mass are given. Precision measurements of these couplings in the future collider experiments are the key to either verifying the mechanism of the electroweak symmetry breaking in the SM or uncovering physics beyond the SM. This article gives an overview of how various Higgs couplings will be measured at the ILC. Emphasis is put on the ILC's capability of performing fully model independent determination of absolute $HZZ$ and $HWW$ couplings, the Higgs total width, and hence various other Higgs couplings, which cover essentially all the crucial ones including the top-Yukawa coupling $Htt$ and the trilinear Higgs self-coupling $\\lambda_{HHH}$. The strategy to get the best precision measurements at the ILC is through staged running, which provides many independent $\\sigma\\times\\mathrm{Br}$ measurements for different p...

  5. Dopamine modulates two potassium currents and inhibits the intrinsic firing properties of an identified motor neuron in a central pattern generator network.

    Science.gov (United States)

    Kloppenburg, P; Levini, R M; Harris-Warrick, R M

    1999-01-01

    The two pyloric dilator (PD) neurons are components [along with the anterior burster (AB) neuron] of the pacemaker group of the pyloric network in the stomatogastric ganglion of the spiny lobster Panulirus interruptus. Dopamine (DA) modifies the motor pattern generated by the pyloric network, in part by exciting or inhibiting different neurons. DA inhibits the PD neuron by hyperpolarizing it and reducing its rate of firing action potentials, which leads to a phase delay of PD relative to the electrically coupled AB and a reduction in the pyloric cycle frequency. In synaptically isolated PD neurons, DA slows the rate of recovery to spike after hyperpolarization. The latency from a hyperpolarizing prestep to the first action potential is increased, and the action potential frequency as well as the total number of action potentials are decreased. When a brief (1 s) puff of DA is applied to a synaptically isolated, voltage-clamped PD neuron, a small voltage-dependent outward current is evoked, accompanied by an increase in membrane conductance. These responses are occluded by the combined presence of the potassium channel blockers 4-aminopyridine and tetraethylammonium. In voltage-clamped PD neurons, DA enhances the maximal conductance of a voltage-sensitive transient potassium current (IA) and shifts its Vact to more negative potentials without affecting its Vinact. This enlarges the "window current" between the voltage activation and inactivation curves, increasing the tonically active IA near the resting potential and causing the cell to hyperpolarize. Thus DA's effect is to enhance both the transient and resting K+ currents by modulating the same channels. In addition, DA enhances the amplitude of a calcium-dependent potassium current (IO(Ca)), but has no effect on a sustained potassium current (IK(V)). These results suggest that DA hyperpolarizes and phase delays the activity of the PD neurons at least in part by modulating their intrinsic postinhibitory recovery

  6. Characterization and modeling of the intrinsic properties of 1.5-micrometer gallium indium nitrogen arsenic antimonide/gallium arsenide laser

    Science.gov (United States)

    Goddard, Lynford

    2005-12-01

    Low cost access to optical communication networks is needed to satisfy the rapidly increasing demands of home-based high-speed Internet. Existing light sources in the low-loss 1.2--1.6mum telecommunication wavelength bandwidth are prohibitively expensive for large-scale deployment, e.g. incorporation in individual personal computers. Recently, we have extended the lasing wavelength of room-temperature CW GaInNAs(Sb) lasers grown monolithically on GaAs by MBE up to 1.52mum in an effort to replace the traditional, more expensive, InP-based devices. Besides lower cost wafers, GaInNAs(Sb) opto-electronic devices have fundamental material advantages over InP-based devices: a larger conduction band offset which reduces temperature sensitivity and enhances differential gain, a lattice match to a material with a large refractive index contrast, i.e. AlAs, which decreases the necessary number of mirror pairs in DBRs for VCSELs, and native oxide apertures for current confinement. High performance GaInNAs(Sb) edge-emitting lasers, VCSELs, and DFB lasers have been demonstrated throughout the entire telecommunication band. In this work, we analyze the intrinsic properties of the GaInNAsSb material system, e.g. recombination, gain, band structure and renormalization, and efficiency. Theoretical modeling is performed to calculate a map of the bandgap and effective masses for various material compositions. We also present device performance results, such as: room temperature CW threshold densities below 450A/cm2, quantum efficiencies above 50%, and over 425mW of total power from a SQW laser when mounted epi-up and minimally packaged. These results are generally 2--4x better than previous world records for GaAs based devices at 1.5mum. The high CW power and low threshold exhibited by these SQW lasers near 1.5mum make feasible many novel applications, such as broadband Raman fiber amplifiers and uncooled WDM at the chip scale. Device reliability of almost 500 hours at 200mW CW

  7. Polarization of ILC2s in Peripheral Blood Might Contribute to Immunosuppressive Microenvironment in Patients with Gastric Cancer

    Directory of Open Access Journals (Sweden)

    Qingli Bie

    2014-01-01

    Full Text Available Newly identified nuocytes or group 2 innate lymphoid cells (ILC2s play an important role in Th2 cell mediated immunity such as protective immune responses to helminth parasites, allergic asthma, and chronic rhinosinusitis. However, the contributions of ILC2s in the occurrence and development of cancer remain unknown. Our previous study found that there was a predominant Th2 phenotype in patients with gastric cancer. In this study, the ILC2s related genes or molecules in PBMC from patients with gastric cancer were measured, and the potential correlation between them was analyzed. The expression levels of RORα, GATA3, T1/ST2, IL-17RB, CRTH2, IL-33, IL-5, and IL-4 mRNA were significantly increased in patients, but no significant changes were found in ICOS, CD45, and IL-13 expression, and there was a positive correlation between RORα or IL-13 and other related factors, such as ICOS and CD45. The increased frequency of ILC2s was also found in PBMC of patients by flow cytometry. In addition, the mRNA of Arg1 and iNOS were also significantly increased in patients. These results suggested that there are polarized ILC2s in gastric cancer patients which might contribute to immunosuppressive microenvironment and closely related to the upregulation of MDSCs and M2 macrophages.

  8. Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving ILC3

    Science.gov (United States)

    Withers, David R.; Hepworth, Matthew R.; Wang, Xinxin; Mackley, Emma C.; Halford, Emily E.; Dutton, Emma E.; Marriott, Clare L.; Brucklacher-Waldert, Verena; Veldhoen, Marc; Kelsen, Judith; Baldassano, Robert N.; Sonnenberg, Gregory F.

    2016-01-01

    RAR-related orphan receptor γt (ROR-γt) directs differentiation of pro-inflammatory T helper 17 (TH17) cells and is a potential therapeutic target in chronic autoimmune and inflammatory diseases1–3. However, ROR-γt-dependent group 3 innate lymphoid cells (ILC3s) provide essential immunity and tissue protection in the intestine4–11, suggesting that targeting ROR-γt could also result in impaired host defense to infection or enhanced tissue damage. Here, we demonstrate that transient chemical inhibition of ROR-γt in mice selectively reduces cytokine production from TH17 cells but not ILC3s in the context of intestinal infection with Citrobacter rodentium, resulting in preserved innate immunity. Transient genetic deletion of ROR-γt in mature ILC3s also did not impair cytokine responses in the steady state or during infection. Finally, pharmacologic inhibition of ROR-γt provided therapeutic benefit in mouse models of intestinal inflammation, and reduced the frequencies of TH17 cells but not ILC3s isolated from primary intestinal samples of individuals with inflammatory bowel disease (IBD). Collectively, these results reveal differential requirements for ROR-γt in the maintenance of TH17 cell versus ILC3 responses, and suggest that transient inhibition of ROR-γt is a safe and effective therapeutic approach during intestinal inflammation. PMID:26878233

  9. Quantitative Property-Property Relationship for Screening-Level Prediction of Intrinsic Clearance of Volatile Organic Chemicals in Rats and Its Integration within PBPK Models to Predict Inhalation Pharmacokinetics in Humans

    Directory of Open Access Journals (Sweden)

    Thomas Peyret

    2012-01-01

    Full Text Available The objectives of this study were (i to develop a screening-level Quantitative property-property relationship (QPPR for intrinsic clearance (CLint obtained from in vivo animal studies and (ii to incorporate it with human physiology in a PBPK model for predicting the inhalation pharmacokinetics of VOCs. CLint, calculated as the ratio of the in vivo Vmax (μmol/h/kg bw rat to the Km (μM, was obtained for 26 VOCs from the literature. The QPPR model resulting from stepwise linear regression analysis passed the validation step (R2=0.8; leave-one-out cross-validation Q2=0.75 for CLint normalized to the phospholipid (PL affinity of the VOCs. The QPPR facilitated the calculation of CLint (L PL/h/kg bw rat from the input data on log Pow, log blood: water PC and ionization potential. The predictions of the QPPR as lower and upper bounds of the 95% mean confidence intervals (LMCI and UMCI, resp. were then integrated within a human PBPK model. The ratio of the maximum (using LMCI for CLint to minimum (using UMCI for CLint AUC predicted by the QPPR-PBPK model was 1.36±0.4 and ranged from 1.06 (1,1-dichloroethylene to 2.8 (isoprene. Overall, the integrated QPPR-PBPK modeling method developed in this study is a pragmatic way of characterizing the impact of the lack of knowledge of CLint in predicting human pharmacokinetics of VOCs, as well as the impact of prediction uncertainty of CLint on human pharmacokinetics of VOCs.

  10. Reservatsioonide lubatavus ning reservatsioonide vastuväidete õiguslik mõju ILC uurimistöö valguses : [bakalaureusetöö] / Marja-Liisa Laatsit ; Tartu Ülikool, õigusteaduskond ; juhendaja: Lauri Mälksoo

    Index Scriptorium Estoniae

    Laatsit, Marja-Liisa

    2009-01-01

    ILC = International Law Commission. - Reservatsioonidest tänases teoorias ja praktikas, vastuväidetest reservatsioonide tegemisele, reservatsioonide lubatavusest ja nende õiguslikust mõjust (ILC eriraportöör Pellet̀ettepanekutest, NATO SOFA lepingust)

  11. Top Quark Polarization and Spin Correlation in the Littlest Higgs Model with T-Parity at the ILC

    Institute of Scientific and Technical Information of China (English)

    YANG Bing-Fang; LI Xiang-Dong

    2013-01-01

    In the framework of the littlest Higgs model with T-parity (LHT),we study the top quark spin correlation and polarization at the International Linear Collider (ILC).We find that the top quark polarization asymmetry δPt and the left-right asymmetry δALR car respectively reach-35% and-37.5% for √s =500 GeV and √s =1000 GeV via e+e-collision,which can reach the observable level at the ILC.By contrast,the spin correlation δC is smaller.The correlation behaviors of these observables at the e+ e-collision and the γγ collision will be helpful to distinguish different models and test the LHT model at the ILC.

  12. A study of the measurement precision of the Higgs boson decaying into tau pairs at the ILC

    Energy Technology Data Exchange (ETDEWEB)

    Kawada, Shin-ichi, E-mail: s-kawada@huhep.org [Advanced Sciences of Matter (AdSM), Hiroshima University, 1-3-1, Kagamiyama, 739-8530, Higashi-Hiroshima, Hiroshima (Japan); Fujii, Keisuke [High Energy Accelerator Research Organization (KEK), 1-1, Oho, 305-0801, Tsukuba, Ibaraki (Japan); Suehara, Taikan [Graduate School of Science, Kyushu University, 6-10-1, Hakozaki, Higashi-ku, 812-8581, Fukuoka (Japan); Takahashi, Tohru [Advanced Sciences of Matter (AdSM), Hiroshima University, 1-3-1, Kagamiyama, 739-8530, Higashi-Hiroshima, Hiroshima (Japan); Tanabe, Tomohiko [International Center for Elementary Particle Physics (ICEPP), The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, 113-0033, Tokyo (Japan)

    2015-12-28

    We evaluate the measurement precision of the production cross section times the branching ratio of the Higgs boson decaying into tau lepton pairs at the International Linear Collider (ILC). We analyze various final states associated with the main production mechanisms of the Higgs boson, the Higgs-strahlung and WW-fusion processes. The statistical precision of the production cross section times the branching ratio is estimated to be 2.6 and 6.9 % for the Higgs-strahlung and WW-fusion processes, respectively, with the nominal integrated luminosities assumed in the ILC Technical Design Report; the precision improves to 1.0 and 3.4 % with the running scenario including possible luminosity upgrades. The study provides a reference performance of the ILC for future phenomenological analyses.

  13. Beam polarization at the ILC. The physics impact and the accelerator solutions

    Energy Technology Data Exchange (ETDEWEB)

    Aurand, B. [Bonn Univ. (Germany). Phys. Inst.; Bailey, I. [Liverpool Univ. (United Kingdom). Cockcroft Inst.; Bartels, C. [DESY, Hamburg (Germany); DESY, Zeuthen (DE)] (and others)

    2009-03-15

    In this contribution accelerator solutions for polarized beams and their impact on physics measurements are discussed. Focus are physics requirements for precision polarimetry near the interaction point and their realization with polarized sources. Based on the ILC baseline programme as described in the Reference Design Report (RDR), recent developments are discussed and evaluated taking into account physics runs at beam energies between 100 GeV and 250 GeV, as well as calibration runs on the Z-pole and options as the 1 TeV upgrade and GigaZ. (orig.)

  14. Controls, LLRF, and instrumentation systems for ILC test facilities at Fermilab

    Energy Technology Data Exchange (ETDEWEB)

    Chase, B.; Votava, M.; Wendt, M.; /Fermilab

    2007-06-01

    The major controls and instrumentation systems for the ILC test areas and the NML test accelerator at Fermilab are discussed. The test areas include 3 separate areas for Vertical Superconducting RF Cavity Testing, Horizontal Cavity Testing, and NML RF and beam test area. A common control infrastructure for the test areas including a controls framework, electronic logbook and cavity database will be provided, while supporting components supplied by collaborators with diverse areas of expertise (EPICS, DOOCS, LabVIEW, and Matlab). The discussions on the instrumentation systems are focused on overview and requirements.

  15. Improved final doublet designs for the ILC baseline small crossing angle scheme

    CERN Document Server

    Appleby, R

    2006-01-01

    The ILC baseline consists of two interaction regions, one with a 20mrad crossing angle and the other with a 2mrad crossing angle. It is known that the outgoing beam losses in the final doublet and subsequent extraction line are larger in the 2mrad than in the 20mrad layout. In this work, we exploit NbTi and Nb$_3$Sn superconducting magnet technologies to redesign and optimise the final doublet, with the aim of providing satisfactory outgoing disrupted beam power losses in this region. We present three new final doublet layouts, specifically optimised for the 500 GeV and the 1 TeV machines.

  16. Development of ultra-light pixelated ladders for an ILC vertex detector

    CERN Document Server

    Chon-Sen, N; Claus, G; De Masi, R; Deveaux, M; Dulinski, W; Goffe, M; Goldstein, J; Gregor, I -M; Imhoff, Ch Hu-Guo M; Müntz, C; Nomerotski, A; Santos, C; Schrader, C; Specht, M; Stroth, J; Winter, M

    2010-01-01

    The development of ultra-light pixelated ladders is motivated by the requirements of the ILD vertex detector at ILC. This paper summarizes three projects related to system integration. The PLUME project tackles the issue of assembling double-sided ladders. The SERWIETE project deals with a more innovative concept and consists in making single-sided unsupported ladders embedded in an extra thin plastic enveloppe. AIDA, the last project, aims at building a framework reproducing the experimental running conditions where sets of ladders could be tested.

  17. CP-sensitive spin-spin correlations in neutralino production at the ILC

    CERN Document Server

    Bartl, A; Kernreiter, T; Kittel, O; Terwort, M

    2009-01-01

    We study the CP-violating terms of the spin-spin correlations in neutralino production and their subsequent two-body decays into sleptons plus leptons at the ILC. We analyze CP-sensitive observables with the help of T-odd products of the spin-spin terms. These terms depend on the polarizations of both neutralinos, with one polarization perpendicular to the production plane. We present a detailed numerical study of the CP-sensitive observables, cross sections, and neutralino branching ratios in the Minimal Supersymmetric Standard Model with complex parameters.

  18. CP-sensitive spin-spin correlations in neutralino production at the ILC

    Science.gov (United States)

    Bartl, A.; Hohenwarter-Sodek, K.; Kernreiter, T.; Kittel, O.; Terwort, M.

    2009-07-01

    We study the CP-violating terms of the spin-spin correlations in neutralino production and their subsequent two-body decays into sleptons plus leptons at the ILC. We analyze CP-sensitive observables with the help of T-odd products of the spin-spin terms. These terms depend on the polarizations of both neutralinos, with one polarization perpendicular to the production plane. We present a detailed numerical study of the CP-sensitive observables, cross sections, and neutralino branching ratios in the Minimal Supersymmetric Standard Model with complex parameters.

  19. RF and data acquisition systems for Fermilab's ILC SRF cavity vertical test stand

    Energy Technology Data Exchange (ETDEWEB)

    Ozelis, Joseph P.; Nehring, Roger; /Fermilab; Grenoble, Christiana; Powers, Thomas J.; /Jefferson Lab

    2007-06-01

    Fermilab is developing a facility for vertical testing of SRF cavities as part of its ILC program. The RF system for this facility is based on the proven production cavity test systems used at Jefferson Lab for CEBAF and SNS cavity testing. The design approach is modular in nature, using commercial-off-the-shelf (COTS) components. This yields a system that can be easily debugged and modified, and with ready availability of spares. Comprehensive data acquisition and control is provided by a PXI-based hardware platform in conjunction with software developed in the LabView programming environment.

  20. Studies on the Electron Reconstruction Efficiency for the Beam Calorimeter of an ILC Detector

    CERN Document Server

    Novgorodova, Olga

    2010-01-01

    In this talk recent simulation results on the single high energy electron reconstruction with the Beam Calorimeter for the ILD detector are presented. Guinea Pig is used to generate the e+e- pair background and GEANT4 for the simulation of electron showers in the calorimeter. An algorithm was developed for the sHEe reconstruction on top of the large e+e- background. The efficiency of the sHEe reconstruction is estimated for the nominal and SB-2009 ILC beam parameters.

  1. Beam Emittance Measurement with Laser Wire Scanners in the ILC Beam Delivery System

    Energy Technology Data Exchange (ETDEWEB)

    Agapov, I.; /CERN; Blair, G.A.; /Royal Holloway, U. of London; Woodley, M.; /SLAC

    2008-02-01

    Accurate measurement of the beam phase-space is essential for the next generation of electron accelerators. A scheme for beam optics optimization and beam matrix reconstruction algorithms for the diagnostics section of the beam delivery system of the International Linear Collider based on laser-wire beam profile monitors are discussed. Possible modes of operation of the laser-wire system together with their corresponding performance are presented. Based on these results, prospects for reconstructing the ILC beam emittance from representative laser-wire beam size measurements are evaluated.

  2. Intrinsic-Density Functionals

    CERN Document Server

    Engel, J

    2006-01-01

    The Hohenberg-Kohn theorem and Kohn-Sham procedure are extended to functionals of the localized intrinsic density of a self-bound system such as a nucleus. After defining the intrinsic-density functional, we modify the usual Kohn-Sham procedure slightly to evaluate the mean-field approximation to the functional, and carefully describe the construction of the leading corrections for a system of fermions in one dimension with a spin-degeneracy equal to the number of particles N. Despite the fact that the corrections are complicated and nonlocal, we are able to construct a local Skyrme-like intrinsic-density functional that, while different from the exact functional, shares with it a minimum value equal to the exact ground-state energy at the exact ground-state intrinsic density, to next-to-leading order in 1/N. We briefly discuss implications for real Skyrme functionals.

  3. Hippocampal cholinergic interneurons visualized with the choline acetyltransferase promoter: anatomical distribution, intrinsic membrane properties, neurochemical characteristics, and capacity for cholinergic modulation

    OpenAIRE

    Feng eYi; Elizabeth eCatudio-Garrett; Robert eGabriel; Marta eWilhelm; Ferenc eErdelyi; Gabor eSzabo; Karl eDeisseroth; Josh eLawrence

    2015-01-01

    Release of acetylcholine (ACh) in the hippocampus (HC) occurs during exploration, arousal, and learning. Although the medial septum-diagonal band of Broca (MS-DBB) is the major extrinsic source of cholinergic input to the HC, cholinergic neurons intrinsic to the HC also exist but remain poorly understood. Here, ChAT-tauGFP and ChAT-CRE/Rosa26YFP (ChAT-Rosa) mice were examined in HC. The HC of ChAT-tauGFP mice was densely innervated with GFP-positive axons, often accompanied by large GFP-posit...

  4. Hippocampal “cholinergic interneurons” visualized with the choline acetyltransferase promoter: anatomical distribution, intrinsic membrane properties, neurochemical characteristics, and capacity for cholinergic modulation

    OpenAIRE

    Yi, Feng; Catudio-Garrett, Elizabeth; Gábriel, Robert; Wilhelm, Marta; Erdelyi, Ferenc; Szabo, Gabor; Deisseroth, Karl; Lawrence, Josh

    2015-01-01

    Release of acetylcholine (ACh) in the hippocampus (HC) occurs during exploration, arousal, and learning. Although the medial septum-diagonal band of Broca (MS-DBB) is the major extrinsic source of cholinergic input to the HC, cholinergic neurons intrinsic to the HC also exist but remain poorly understood. Here, ChAT-tauGFP and ChAT-CRE/Rosa26YFP (ChAT-Rosa) mice were examined in HC. The HC of ChAT-tauGFP mice was densely innervated with GFP-positive axons, often accompanied by large GFP-posit...

  5. Measurement of CP asymmetries in neutralino production at the ILC

    Science.gov (United States)

    Kittel, O.; Moortgat-Pick, G.; Rolbiecki, K.; Schade, P.; Terwort, M.

    2012-01-01

    We study the prospects to measure the CP-sensitive triple-product asymmetries in neutralino production e+ e- totilde{χ}0itilde{χ}01 and subsequent leptonic two-body decays tilde{χ}0i to tilde{ell}R ell, tilde{ell}R to tilde{χ}01 ell, for ℓ= e, μ, within the Minimal Supersymmetric Standard Model. We include a full detector simulation of the International Large Detector for the International Linear Collider. The simulation was performed at a center-of-mass energy of sqrt{s}=500 GeV, including the relevant Standard Model background processes, a realistic beam energy spectrum, beam backgrounds and a beam polarization of 80% and -60% for the electron and positron beams, respectively. In order to effectively disentangle different signal samples and reduce SM and SUSY backgrounds we apply a method of kinematic reconstruction. Assuming an integrated luminosity of 500 fb-1 collected by the experiment and the performance of the current ILD detector, we arrive at a relative measurement accuracy of 10% for the CP-sensitive asymmetry in our scenario. We demonstrate that our method of signal selection using kinematic reconstruction can be applied to a broad class of scenarios and it allows disentangling processes with similar kinematic properties.

  6. Measurement of CP asymmetries in neutralino production at the ILC

    Energy Technology Data Exchange (ETDEWEB)

    Kittel, O. [Universidad de Granada, Departamento de Fisica Teorica y del Cosmos and CAFPE, Granada (Spain); Moortgat-Pick, G. [University of Hamburg, Hamburg (Germany); DESY, Hamburg (Germany); Rolbiecki, K.; Terwort, M. [DESY, Hamburg (Germany); Schade, P. [DESY, Hamburg (Germany); CERN, Geneve 23 (Switzerland)

    2012-01-15

    We study the prospects to measure the CP-sensitive triple-product asymmetries in neutralino production e{sup +}e{sup -} {yields} {chi}{sup 0}{sub i}{chi}{sup 0}{sub 1} and subsequent leptonic two-body decays {chi}{sup 0}{sub i} {yields} l{sub R}l, l{sub R} {yields} {chi}{sup 0}{sub 1}l, for l = e,{mu}, within the Minimal Supersymmetric Standard Model. We include a full detector simulation of the International Large Detector for the International Linear Collider. The simulation was performed at a center-of-mass energy of {radical}(s)=500 GeV, including the relevant Standard Model background processes, a realistic beam energy spectrum, beam backgrounds and a beam polarization of 80% and -60% for the electron and positron beams, respectively. In order to effectively disentangle different signal samples and reduce SM and SUSY backgrounds we apply a method of kinematic reconstruction. Assuming an integrated luminosity of 500 fb{sup -1} collected by the experiment and the performance of the current ILD detector, we arrive at a relative measurement accuracy of 10% for the CP-sensitive asymmetry in our scenario. We demonstrate that our method of signal selection using kinematic reconstruction can be applied to a broad class of scenarios and it allows disentangling processes with similar kinematic properties. (orig.)

  7. Investigation of the physics potential and detector development for the ILC

    Energy Technology Data Exchange (ETDEWEB)

    Ohlerich, Martin

    2010-02-15

    In this thesis, we investigate two rather separate topics - the precision measurement of the Higgs boson mass and of its coupling to the neutral gauge boson Z and the research and development of sensors for BEAMCAL, which is a sub-detector system of the ILC detector. We employ the Higgs-strahlung process for this purpose. A virtual Z boson is created in the e{sup +}e{sup -} collisions, which emits a Higgs-boson while becoming on-shell. Using the so-called recoil technique, we determine the Higgs boson mass by reconstructing the Z boson momentum and using the center-of-mass energy of the colliding leptons. Monte-Carlo studies including a full detector simulation and a full event reconstruction were performed to simulate the impact of a realistic detector model on the precision of the Higgs boson mass and production cross-section measurement. Also, an analytical estimate of the influence of a given detector performance on the Higgs boson mass measurement uncertainty is given. We included a complete sample of background events predicted by the Standard Model, which may have a detector response similar to the signal events. A probabilistic method is used for the signal-background separation. Several other probabilistic methods were used to investigate and improve the measurement of the Higgs-strahlung cross-section and the Higgs boson mass from the recoil mass spectrum obtained after the signal-background separation. For a Higgs boson mass of 120 GeV, a center-of-mass energy of {radical}(s)=250 GeV and an integrated luminosity of L=50 fb{sup -1}, a relative uncertainty of 10 % is obtained for the cross-section measurement, and a precision of 118 MeV for the Higgs boson mass. For a Higgs boson mass of 180 GeV and {radical}(s)=350 GeV, a statistics corresponding to L=50 fb{sup -1} is not sufficient to achieve the necessary significance of the recoil mass peak above the background. The BEAMCAL is a calorimeter in the very forward region, about 3 m away from the nominal

  8. Precision study of ZZγ production including Z-boson leptonic decays at the ILC

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yu; Duan, Peng-Fei [Kunming University of Science and Technology, City College, Kunming, Yunnan (China); Ma, Wen-Gan; Zhang, Ren-You; Chen, Chong [University of Science and Technology of China (USTC), Department of Modern Physics, Hefei, Anhui (China)

    2016-02-15

    We report on the precision predictions for the e{sup +}e{sup -} → ZZγ process including Z-boson leptonic decays at the ILC in the standard model (SM). The calculation includes the full next-to-leading (NLO) electroweak (EW) corrections and high order initial state radiation (h.o. ISR) contributions. We find that the NLO EW corrections heavily suppress the LO cross section, and the h.o. ISR effects are notable near the threshold while become small in high energy region. We present the LO and the NLO EW+h.o. ISR corrected distributions of the transverse momenta of final Z-boson and photon as well as the Z-pair invariant mass, and we investigate the corresponding NLO EW and h.o. ISR relative corrections. We also study the leptonic decays of the final Z-boson pair by adopting the MadSpin method where the spin correlation effect is involved. We conclude that both the h.o. ISR effects and the NLO EW corrections are important in exploring the ZZγ production at the ILC. (orig.)

  9. Precision study on $ZZ\\gamma$ production including $Z$-boson leptonic decays at the ILC

    CERN Document Server

    Yu, Zhang; Wen-Gan, Ma; Ren-You, Zhang; Chong, Chen

    2015-01-01

    We report on the precision predictions for the \\eezzr process including $Z$-boson leptonic decays at the ILC in the standard model (SM). The calculation includes the full next-to-leading (NLO) electroweak (EW) corrections and high order initial state radiation (h.o.ISR) contributions. We find that the NLO EW corrections heavily suppress the LO cross section, and the h.o.ISR effects are notable near the threshold while become small in high energy region. We present the LO and the NLO EW+h.o.ISR corrected distributions of the transverse momenta of final $Z$-boson and photon as well as the $Z$-pair invariant mass, and investigate the corresponding NLO EW and h.o.ISR relative corrections. We also study the leptonic decays of the final $Z$-boson pair by adopting the {\\sc MadSpin} method where the spin correlation effect is involved. We conclude that both the h.o.ISR effects and the NLO EW corrections are important in exploring the $ZZ\\gamma$ production at the ILC.

  10. Compact Low-Voltage, High-Power, Multi-beam Klystron for ILC: Initial Test Results

    CERN Document Server

    Teryaev, V E; Kazakov, S Yu; Hirshfield, J L; Ives, R L; Marsden, D; Collins, G; Karimov, R; Jensen, R

    2015-01-01

    Initial test results of an L-band multi-beam klystron with parameters relevant for ILC are presented. The chief distinction of this tube from MBKs already developed for ILC is its low operating voltage of 60 kV, a virtue that implies considerable technological simplifications in the accelerator complex. To demonstrate the concept underlying the tubes design, a six-beamlet quadrant (a 54 inch high one-quarter portion of the full 1.3 GHz tube) was built and recently underwent initial tests, with main goals of demonstrating rated gun perveance, rated gain, and at least one-quarter of the full 10-MW rated power. Our initial three-day conditioning campaign without RF drive (140 microsec pulses @ 60 Hz) was stopped at 53% of full rated duty because of time-limits at the test-site; no signs appeared that would seem to prevent achieving full duty operation (i.e., 1.6 msec pulses @ 10 Hz). The subsequent tests with 10-15 microsec RF pulses confirmed the rated gain, produced output powers of up to 2.86 MW at 60 kV with...

  11. Initial results of a silicon sensor irradiation study for ILC extreme forward calorimetry

    Energy Technology Data Exchange (ETDEWEB)

    Band, Reyer; Fadeyev, Vitaliy [Santa Cruz Institute for Particle Physics and the University of California, 1156 High Street, Santa Cruz, CA 95064 (United States); Field, R. Clive [SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025 (United States); Key, Spencer; Kim, Tae Sung [Santa Cruz Institute for Particle Physics and the University of California, 1156 High Street, Santa Cruz, CA 95064 (United States); Markiewicz, Thomas [SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025 (United States); Martinez-McKinney, Forest [Santa Cruz Institute for Particle Physics and the University of California, 1156 High Street, Santa Cruz, CA 95064 (United States); Maruyama, Takashi [SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025 (United States); Mistry, Khilesh; Nidumolu, Ravi [Santa Cruz Institute for Particle Physics and the University of California, 1156 High Street, Santa Cruz, CA 95064 (United States); Schumm, Bruce A., E-mail: baschumm@ucsc.edu [Santa Cruz Institute for Particle Physics and the University of California, 1156 High Street, Santa Cruz, CA 95064 (United States); Spencer, Edwin; Timlin, Conor; Wilder, Max [Santa Cruz Institute for Particle Physics and the University of California, 1156 High Street, Santa Cruz, CA 95064 (United States)

    2014-11-21

    Detectors proposed for the International Linear Collider (ILC) incorporate a tungsten sampling calorimeter (‘BeamCal’) intended to reconstruct showers of electrons, positrons and photons that emerge from the interaction point of the collider with angles between 5 and 50 milliradians. For the innermost radius of this calorimeter, radiation doses at shower-max are expected to reach 100 MRad per year, primarily due to minimum-ionizing electrons and positrons that arise in the induced electromagnetic showers of e+e− ‘beamstrahlung’ pairs produced in the ILC beam–beam interaction. However, radiation damage to calorimeter sensors may be dominated by hadrons induced by nuclear interactions of shower photons, which are much more likely to contribute to the non-ionizing energy loss that has been observed to damage sensors exposed to hadronic radiation. We report here on the results of SLAC Experiment T-506, for which several different types of silicon diode sensors were exposed to doses of radiation induced by showering electrons of energy 3.5–10.6 GeV. By embedding the sensor under irradiation within a tungsten radiator, the exposure incorporated hadronic species that would potentially contribute to the degradation of a sensor mounted in a precision sampling calorimeter. Depending on sensor technology, efficient charge collection was observed for doses as large as 220 MRad.

  12. Contact Interactions in Higgs-Vector Boson Associated Production at the ILC

    CERN Document Server

    Cohen, Jonathan; Eilam, Gad

    2016-01-01

    We explore new physics (NP) effects in Higgs-Vector boson associated production at a future International Linear Collider (ILC) via e+e- -> Zh,Zhh, using effective field theory (EFT) techniques. In particular, we focus on a certain class of dimension 6 operators, which are generated by tree-level exchanges of a new heavy vector field in the underlying theory. These operators induce new contact terms of the form \\psi\\psi\\phi D\\phi, involving the Standard Model (SM) fermions (\\psi), gauge-bosons (D is the covariant derivative) and the SM Higgs field (\\phi). We investigate the high-energy behaviour of these new effective interactions in e+e- -> Zh,Zhh, imposing bounds from electroweak precision measurements, and show that the ILC is an excellent testing ground for probing this type of NP via e+e- -> Zh,Zhh. We also address the validity of the EFT expansion and we study the correlation between the hZ and hhZ signals, which can be utilized in future searches for NP in these channels.

  13. Updated Results of a Solid-State Sensor Irradiation Study for ILC Extreme Forward Calorimetry

    CERN Document Server

    Courcoubetis, George; Fadeyev, Vitaliy; Kelley, Thomas; Martinez-McKinney, Forest; Schumm, Bruce A; Spencer, Edwin; Tang, Vivian; Wilder, Max

    2015-01-01

    Detectors proposed for the International Linear Collider (ILC) incorporate a tungsten sampling calorimeter (`BeamCal') intended to reconstruct showers of electrons, positrons and photons that emerge from the interaction point of the collider with angles between 5 and 50 milliradians. For the innermost radius of this calorimeter, radiation doses at shower-max are expected to reach 100 MRad per year, primarily due to minimum-ionizing electrons and positrons that arise in the induced electromagnetic showers of e+e- `beamstrahlung' pairs produced in the ILC beam-beam interaction. However, radiation damage to calorimeter sensors may be dominated by hadrons induced by nuclear interactions of shower photons, which are much more likely to contribute to the non-ionizing energy loss that has been observed to damage sensors exposed to hadronic radiation. We report here on the results of SLAC Experiment T-506, for which several different types of silicon diode and gallium-arsenide sensors were exposed to doses of radiati...

  14. Initial results of a silicon sensor irradiation study for ILC extreme forward calorimetry

    Science.gov (United States)

    Band, Reyer; Fadeyev, Vitaliy; Field, R. Clive; Key, Spencer; Kim, Tae Sung; Markiewicz, Thomas; Martinez-McKinney, Forest; Maruyama, Takashi; Mistry, Khilesh; Nidumolu, Ravi; Schumm, Bruce A.; Spencer, Edwin; Timlin, Conor; Wilder, Max

    2014-11-01

    Detectors proposed for the International Linear Collider (ILC) incorporate a tungsten sampling calorimeter ('BeamCal') intended to reconstruct showers of electrons, positrons and photons that emerge from the interaction point of the collider with angles between 5 and 50 milliradians. For the innermost radius of this calorimeter, radiation doses at shower-max are expected to reach 100 MRad per year, primarily due to minimum-ionizing electrons and positrons that arise in the induced electromagnetic showers of e+e- 'beamstrahlung' pairs produced in the ILC beam-beam interaction. However, radiation damage to calorimeter sensors may be dominated by hadrons induced by nuclear interactions of shower photons, which are much more likely to contribute to the non-ionizing energy loss that has been observed to damage sensors exposed to hadronic radiation. We report here on the results of SLAC Experiment T-506, for which several different types of silicon diode sensors were exposed to doses of radiation induced by showering electrons of energy 3.5-10.6 GeV. By embedding the sensor under irradiation within a tungsten radiator, the exposure incorporated hadronic species that would potentially contribute to the degradation of a sensor mounted in a precision sampling calorimeter. Depending on sensor technology, efficient charge collection was observed for doses as large as 220 MRad.

  15. Initial Results of a Silicon Sensor Irradiation Study for ILC Extreme Forward Calorimetry

    CERN Document Server

    Band, R; Field, R C; Key, S; Kim, T; Markiewicz, T; Martinez-McKinney, F; Maruyama, T; Mistry, K; Nidumolu, R; Schumm, B A; Spencer, E; Timlin, C; Wilder, M

    2014-01-01

    Detectors proposed for the International Linear Collider (ILC) incorporate a tungsten sampling calorimeter (`BeamCal') intended to reconstruct showers of electrons, positrons and photons that emerge from the interaction point of the collider with angles between 5 and 50 milliradians. For the innermost radius of this calorimeter, radiation doses at shower-max are expected to reach 100 MRad per year, primarily due to minimum-ionizing electrons and positrons that arise in the induced electromagnetic showers of e+e- `beamstrahlung' pairs produced in the ILC beam-beam interaction. However, radiation damage to calorimeter sensors may be dominated by hadrons induced by nuclear interactions of shower photons, which are much more likely to contribute to the non-ionizing energy loss that has been observed to damage sensors exposed to hadronic radiation. We report here on the results of SLAC Experiment T-506, for which several different types of silicon diode sensors were exposed to doses of radiation induced by showeri...

  16. Influence of anomalous VVH and VVHH on determination of Higgs self couplings at ILC

    CERN Document Server

    Kumar, Satendra

    2014-01-01

    The recent discovery of a Higgs boson at LHC, while establishing the Higgs mechanism as the way of electroweak symmetry breaking, started an era of precision measurements involving the Higgs boson. In an effective Lagrangian framework, we consider the e+e- --> ZHH process, at an ILC running at a centre of mass energy of 800 GeV to investigate the effect of the ZZH and ZZHH couplings on the sensitivity of HHH coupling on this process. Our results show that the sensitivity of the trilinear Higgs self couplings on this process has somewhat strong dependence on the Higgs-gauge boson couplings. Single and two parameter reach of ILC with integrated luminosity of 1000 /fb are obtained on the effective couplings, c6 and cH, which are related to the HHH couplings, indicating how these limits are affected by the presence of anomalous ZZH and ZZHH couplings. The kinematic distributions studied to understand the effect of the anomalous couplings, again, show strong influence of Z-H couplings on the dependence of these di...

  17. Updated Results of a Solid-State Sensor Irradiation Study for ILC Extreme Forward Calorimetry

    CERN Document Server

    Courcoubetis, George; Fadeyev, Vitaliy; Fink, Caleb; Guillemaud, Nikolas; Renteria, Cesar Gonzalez; Gruey, Benjamin; LaBarre, Patrick; Martinez-McKinney, Forest; Rischbieter, Greg; Schumm, Bruce A; Spencer, Edwin; Wilder, Max

    2016-01-01

    Detectors proposed for the International Linear Collider (ILC) incorporate a tungsten sampling calorimeter (`BeamCal') intended to reconstruct showers of electrons, positrons and photons that emerge from the interaction point of the collider with angles between 5 and 50 milliradians. For the innermost radius of this calorimeter, radiation doses at shower max are expected to reach 100 Mrad per year, primarily due to minimum-ionizing electrons and positrons that arise in the induced electromagnetic showers of e+e- `beamstrahlung' pairs produced in the ILC beam-beam interaction. However, radiation damage to calorimeter sensors may be dominated by hadrons induced by nuclear interactions of shower photons, which are much more likely to contribute to the non-ionizing energy loss that has been observed to damage sensors exposed to hadronic radiation. We report here on the results of SLAC Experiment T-506, for which several different types of silicon diode and gallium-arsenide sensors were exposed to doses of radiati...

  18. Precision gaugino mass measurements as a probe of large trilinear soft terms at ILC

    CERN Document Server

    Bae, Kyu Jung; Nagata, Natsumi; Serce, Hasan

    2016-01-01

    In supersymmetric models with radiatively-driven naturalness, higgsino-like electroweak-inos (EW-inos) are expected to lie in a mass range 100--300 GeV, the lighter the more natural. Such states can be pair-produced at high rates at ILC where their masses are nearly equal to the value of the superpotential mu parameter while their mass splittings depend on the gaugino masses M_1 and M_2. The gaugino masses in turn depend on trilinear soft terms---the A parameters, which are expected to lie in the multi-TeV range owing to the 125 GeV Higgs mass---via two-loop contributions to renormalization group running. We examine the extent to which ILC is sensitive to large A-terms via precision EW-ino mass measurement. Extraction of gaugino masses at the percent level should allow for interesting probes of large trilinear soft SUSY breaking terms under the assumption of unified gaugino masses.

  19. Parameter likelihood of intrinsic ellipticity correlations

    CERN Document Server

    Capranico, Federica; Schaefer, Bjoern Malte

    2012-01-01

    Subject of this paper are the statistical properties of ellipticity alignments between galaxies evoked by their coupled angular momenta. Starting from physical angular momentum models, we bridge the gap towards ellipticity correlations, ellipticity spectra and derived quantities such as aperture moments, comparing the intrinsic signals with those generated by gravitational lensing, with the projected galaxy sample of EUCLID in mind. We investigate the dependence of intrinsic ellipticity correlations on cosmological parameters and show that intrinsic ellipticity correlations give rise to non-Gaussian likelihoods as a result of nonlinear functional dependencies. Comparing intrinsic ellipticity spectra to weak lensing spectra we quantify the magnitude of their contaminating effect on the estimation of cosmological parameters and find that biases on dark energy parameters are very small in an angular-momentum based model in contrast to the linear alignment model commonly used. Finally, we quantify whether intrins...

  20. Lorentz invariant intrinsic decoherence

    CERN Document Server

    Milburn, G J

    2003-01-01

    Quantum decoherence can arise due to classical fluctuations in the parameters which define the dynamics of the system. In this case decoherence, and complementary noise, is manifest when data from repeated measurement trials are combined. Recently a number of authors have suggested that fluctuations in the space-time metric arising from quantum gravity effects would correspond to a source of intrinsic noise, which would necessarily be accompanied by intrinsic decoherence. This work extends a previous heuristic modification of Schr\\"{o}dinger dynamics based on discrete time intervals with an intrinsic uncertainty. The extension uses unital semigroup representations of space and time translations rather than the more usual unitary representation, and does the least violence to physically important invariance principles. Physical consequences include a modification of the uncertainty principle and a modification of field dispersion relations, in a way consistent with other modifications suggested by quantum grav...

  1. Intrinsic Time Quantum Geometrodynamics

    CERN Document Server

    Ita, Eyo Eyo; Yu, Hoi-Lai

    2015-01-01

    Quantum Geometrodynamics with intrinsic time development and momentric variables is presented. An underlying SU(3) group structure at each spatial point regulates the theory. The intrinsic time behavior of the theory is analyzed, together with its ground state and primordial quantum fluctuations. Cotton-York potential dominates at early times when the universe was small; the ground state naturally resolves Penrose's Weyl Curvature Hypothesis, and thermodynamic and gravitational `arrows of time' point in the same direction. Ricci scalar potential corresponding to Einstein's General Relativity emerges as a zero-point energy contribution. A new set of fundamental canonical commutation relations without Planck's constant emerges from the unification of Gravitation and Quantum Mechanics.

  2. Characterization and Comparison of Control Units for Piezo Actuators to be used for Lorentz Force Compensation inth ILC

    Energy Technology Data Exchange (ETDEWEB)

    Bhattacharyya, Sampriti; Pilipenko, Roman; /Fermilab

    2010-01-01

    Superconducting accelerators, such as the International Linear Collider (ILC), rely on very high Q accelerating cavities to achieve high electric fields at low RF power. Such cavities have very narrow resonances: a few kHz with a 1.3GHz resonance frequency for the ILC. Several mechanical factors cause tune shifts much larger than this: pressure variations in the liquid helium bath; microphonics from pumps and other mechanical devices; and for a pulsed machine such as the ILC, Lorentz force detuning (pressure from the contained RF field). Simple passive stiffening is limited by many manufacturing and material considerations. Therefore, active tuning using piezo actuators is needed. Here we study a supply for their operation. Since commercial power amplifiers are expensive, we analyzed the characteristics of four power amplifiers: (iPZD) built by Istituto Nazionale di Fisica Nucleare (Sezione di Pisa); and a DC-DC converter power supply built in Fermilab (Piezo Master); and two commercial amplifiers, Piezosystem jena and Piezomechanik. This paper presents an analysis and characterization of these amplifiers to understand the cost benefit and reliability when using in a large scale, pulsed beam accelerator like the ILC.

  3. Intrinsic contractures of the hand.

    Science.gov (United States)

    Paksima, Nader; Besh, Basil R

    2012-02-01

    Contractures of the intrinsic muscles of the fingers disrupt the delicate and complex balance of intrinsic and extrinsic muscles, which allows the hand to be so versatile and functional. The loss of muscle function primarily affects the interphalangeal joints but also may affect etacarpophalangeal joints. The resulting clinical picture is often termed, intrinsic contracture or intrinsic-plus hand. Disruption of the balance between intrinsic and extrinsic muscles has many causes and may be secondary to changes within the intrinsic musculature or the tendon unit. This article reviews diagnosis, etiology, and treatment algorithms in the management of intrinsic contractures of the fingers. Copyright © 2012 Elsevier Inc. All rights reserved.

  4. Predicting Intrinsic Motivation

    Science.gov (United States)

    Martens, Rob; Kirschner, Paul A.

    2004-01-01

    Intrinsic motivation can be predicted from participants' perceptions of the social environment and the task environment (Ryan & Deci, 2000)in terms of control, relatedness and competence. To determine the degree of independence of these factors 251 students in higher vocational education (physiotherapy and hotel management) indicated the extent to…

  5. Power Losses in the ILC 20-Mrad Extraction Line at 1-TeV

    Energy Technology Data Exchange (ETDEWEB)

    Ferrari, Arnaud; /Uppsala U.; Nosochkov, Yuri; /SLAC

    2007-07-02

    The authors have performed a detailed study of the power losses in the post-collision extraction line of a TeV e{sup +}e{sup -} collider with a crossing angle of 20 mrad at the interaction point. Five cases were considered: four luminosity configurations for ILC and one for CLIC. For all of them, the strong beam-beam effects at the interaction point lead to an emittance growth for the outgoing beam, as well as to the production of beamstrahlung photons and e{sup +}e{sup -} coherent pairs. The power losses along the extraction line, which are due to energy deposition by a fraction of the disrupted beam, of the beamstrahlung photons and of the coherent pairs, were estimated in the case of ideal collisions, as well as with a vertical position or angular offset at the interaction point.

  6. A closer look at the beam-beam processes at ILC and CLIC

    CERN Document Server

    Hartin, Anthony

    2012-01-01

    The strength of the electromagnetic fields in the bunch collision at a linear collider will have a significant effect, yielding large numbers of beamstrahlung photons and associated coherent pair production. These effects are limited in the proposed ILC beam parameters which limit the strength of the bunch field to $\\Upsilon_{\\text{ave}}=0.27$. The CLIC 3 Tev design by comparison has a $\\Upsilon_{\\text{ave}}=3.34$ yielding huge number of coherent pairs. In terms of the precision physics programs of these proposed colliders there is an imperative to investigate the effect of the strong bunch fields on higher order processes. From the exact wavefunctions used in the calculation of transition rates within the Furry interaction picture, and using appropriate simplifications, a multiplicative factor to the coupling constants was obtained. This indicates a significant variation to the transition rate near threshold energies. Further studies are in progress to calculate the exact effect on expected observables.

  7. Testing the CP-violating MSSM in stau decays at the LHC and ILC

    CERN Document Server

    Dreiner, Herbi; Kulkarni, Suchita; Marold, Anja

    2010-01-01

    We study CP violation in the two-body decay of a scalar tau into a neutralino and a tau, which should be probed at the LHC and ILC. From the normal tau polarization, a CP asymmetry is defined which is sensitive to the CP phases of the trilinear scalar coupling parameter $A_\\tau$, the gaugino mass parameter $M_1$, and the higgsino mass parameter $\\mu$, in the stau-neutralino sector of the Minimal Supersymmetric Standard Model. Asymmetries of more than 70% are obtained in scenarios with strong stau mixing. As a result, detectable CP asymmetries in stau decays at the LHC are found, motivating further detailed experimental studies for probing the SUSY CP phases.

  8. Testing the CP-violating MSSM in stau decays at the LHC and ILC

    Science.gov (United States)

    Dreiner, Herbi; Kittel, Olaf; Kulkarni, Suchita; Marold, Anja

    2011-05-01

    We study CP violation in the two-body decay of a scalar tau into a neutralino and a tau, which should be probed at the LHC and ILC. From the normal tau polarization, a CP asymmetry is defined which is sensitive to the CP phases of the trilinear scalar coupling parameter Aτ, the gaugino mass parameter M1, and the Higgsino mass parameter μ, in the stau-neutralino sector of the minimal supersymmetric standard model. Asymmetries of more than 70% are obtained in scenarios with strong stau mixing. As a result, detectable CP asymmetries in stau decays at the LHC are found, motivating further detailed experimental studies for probing the supersymmetry CP phases.

  9. Development and characterization of a DEPFET pixel prototype system for the ILC vertex detector

    Energy Technology Data Exchange (ETDEWEB)

    Kohrs, Robert

    2008-09-15

    For the future TeV-scale linear collider ILC (International Linear Collider) a vertex detector of unprecedented performance is needed to fully exploit its physics potential. By incorporating a field effect transistor into a fully depleted sensor substrate the DEPFET (Depleted Field Effect Transistor) sensor combines radiation detection and in-pixel amplification. For the operation at a linear collider the excellent noise performance of DEPFET pixels allows building very thin detectors with a high spatial resolution and a low power consumption. With this thesis a prototype system consisting of a 64 x 128 pixels sensor, dedicated steering and readout ASICs and a data acquisition board has been developed and successfully operated in the laboratory and under realistic conditions in beam test environments at DESY and CERN. A DEPFET matrix has been successfully read out using the on-chip zero-suppression of the readout chip CURO 2. The results of the system characterization and beam test results are presented. (orig.)

  10. Measuring BR($h \\to \\tau ^+ \\tau ^-$) at the ILC: a full simulation study

    CERN Document Server

    Kawada, Shin-ichi; Suehara, Taikan; Takahashi, Tohru; Tanabe, Tomohiko; Yokoyama, Harumichi

    2015-01-01

    We evaluate the expected measurement accuracy of the branching ratio of the Standard Model Higgs boson decaying into tau pairs at the ILC with a full simulation of the ILD detector concept. We assume a Higgs mass of 125 GeV, a branching ratio of BR($h \\to \\tau ^+ \\tau ^-$) = 6.32%, a beam polarization of electron (positron) of -0.8(+0.3), and an integrated luminosity of 250 fb$^{-1}$. The Higgs-strahlung process $e^+ e^- \\to Zh$ with $Z \\to q\\overline{q}$ is analyzed. We estimate the measurement accuracy of the branching ratio $\\Delta (\\sigma \\times \\mathrm{BR}) / (\\sigma \\times \\mathrm{BR})$ to be 3.4% with using a multivariate analysis technique.

  11. Multi-Bunch Simulations of the ILC for Luminosity Performance Studies

    CERN Document Server

    White, Glen; Walker, Nicholas J

    2005-01-01

    To study the luminosity performance of the International Linear Collider (ILC) with different design parameters, a simulation was constructed that tracks a multi-bunch representation of the beam from the Damping Ring extraction through to the Interaction Point. The simulation code PLACET is used to simulate the LINAC, MatMerlin is used to track through the Beam Delivery System and GUINEA-PIG for the beam-beam interaction. Included in the simulation are ground motion and wakefield effects, intra-train fast feedback and luminosity-based feedback systems. To efficiently study multiple parameters/multiple seeds, the simulation is deployed on the Queen Mary High-Throughput computing cluster at Queen Mary, University of London, where 100 simultaneous simulation seeds can be run.

  12. Beam Ion Instability in ILC Damping Ring with Multi-Gas Species

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Lanfa; Pivi, Mauro; /SLAC

    2012-05-30

    Ion induced beam instability is one critical issue for the electron damping ring of the International Linear Collider (ILC) due to its ultra small emittance of 2 pm. The beam ion instability with various beam filling patterns for the latest lattice DTC02 is studied using PIC code. The code has been benchmarked with SPEAR3 experimental data and there is a good agreement between the simulation and observations. It uses the optics from MAD and can handle arbitrary beam filling pattern and vacuum. Different from previous studies, multi-gas species and exact beam filling patterns have been modeled simultaneously in the study. This feature makes the study more realistic. Analyses have been done to compare with the simulations.

  13. Multi-Bunch Simulations of the ILC for Luminosity Performance Studies

    Energy Technology Data Exchange (ETDEWEB)

    White, G.; /SLAC /Queen Mary, U. of London; Walker, N.; /DESY; Schulte, D.; /CERN

    2005-07-11

    To study the luminosity performance of the International Linear Collider (ILC) with different design parameters, a simulation was constructed that tracks a multi-bunch representation of the beam from the Damping Ring extraction through to the Interaction Point. The simulation code PLACET is used to simulate the LINAC, MatMerlin is used to track through the Beam Delivery System and GUINEA-PIG for the beam-beam interaction. Included in the simulation are ground motion and wakefield effects, intra-train fast feedback and luminosity-based feedback systems. To efficiently study multiple parameters/multiple seeds, the simulation is deployed on the Queen Mary High-Throughput computing cluster at Queen Mary, University of London, where 100 simultaneous simulation seeds can be run.

  14. Simple intrinsic defects in InAs :

    Energy Technology Data Exchange (ETDEWEB)

    Schultz, Peter Andrew

    2013-03-01

    This Report presents numerical tables summarizing properties of intrinsic defects in indium arsenide, InAs, as computed by density functional theory using semi-local density functionals, intended for use as reference tables for a defect physics package in device models.

  15. Intrinsic microwave dielectric loss of lanthanum aluminate.

    Science.gov (United States)

    Shimada, Takeshi; Ichikawa, Koji; Minemura, Tetsuro; Yamauchi, Hiroki; Utsumi, Wataru; Ishii, Yoshinobu; Breeze, Jonathan; Alford, Neil McN

    2010-10-01

    The intrinsic dielectric properties of LaAlO₃ were investigated to understand the microwave properties of several materials containing LaAlO₃. In this study, LaAlO₃ single crystals were prepared by the Czochralski method. The temperature dependence of the dielectric properties and neutron inelastic scattering of the single crystals were measured. From these data, the intrinsic dielectric properties were evaluated and it was found that the dielectric loss of the LaAlO₃ includes two types of dielectric loss. One is a phonon absorption-related loss and the other is a component of the loss arising from Debye- type orientation polarization. The latter affects the room temperature dielectric loss in materials containing LaAlO₃. The present study suggests that avoiding this polarization loss is an important goal in decreasing the total dielectric loss.

  16. Intrinsically photosensitive retinal ganglion cell function in relation to age: A pupillometric study in humans with special reference to the age-related optic properties of the lens

    Directory of Open Access Journals (Sweden)

    Herbst Kristina

    2012-04-01

    Full Text Available Abstract Background The activity of melanopsin containing intrinsically photosensitive ganglion retinal cells (ipRGC can be assessed by a means of pupil responses to bright blue (appr.480 nm light. Due to age related factors in the eye, particularly, structural changes of the lens, less light reaches retina. The aim of this study was to examine how age and in vivo measured lens transmission of blue light might affect pupil light responses, in particular, mediated by the ipRGC. Methods Consensual pupil responses were explored in 44 healthy subjects aged between 26 and 68 years. A pupil response was recorded to a continuous 20 s light stimulus of 660 nm (red or 470 nm (blue both at 300 cd/m2 intensity (14.9 and 14.8 log photons/cm2/s, respectively. Additional recordings were performed using four 470 nm stimulus intensities of 3, 30, 100 and 300 cd/m2. The baseline pupil size was measured in darkness and results were adjusted for the baseline pupil and gender. The main outcome parameters were maximal and sustained pupil contraction amplitudes and the postillumination response assessed as area under the curve (AUC over two time-windows: early (0–10 s after light termination and late (10–30 s after light termination. Lens transmission was measured with an ocular fluorometer. Results The sustained pupil contraction and the early poststimulus AUC correlated positively with age (p = 0.02, p = 0.0014, respectively for the blue light stimulus condition only. The maximal pupil contraction amplitude did not correlate to age either for bright blue or red light stimulus conditions. Lens transmission decreased linearly with age (p 2 light (p = 0.02. Conclusions Age did not reduce, but rather enhance pupil responses mediated by ipRGC. The age related decrease of blue light transmission led to similar results, however, the effect of age was greater on these pupil responses than that of the lens transmission. Thus there must

  17. Synthesis and gas permeation properties of a novel thermally-rearranged polybenzoxazole made from an intrinsically microporous hydroxyl-functionalized triptycene-based polyimide precursor

    KAUST Repository

    Alghunaimi, Fahd

    2017-06-06

    A hydroxyl-functionalized triptycene-based polyimide of intrinsic microporosity (TDA1-APAF) was converted to a polybenzoxazole (PBO) by heat treatment at 460 °C under nitrogen atmosphere. TDA1-APAF treated for 15 min (TR 460) resulted in a PBO conversion of 95% based on a theoretical weight loss of 11.7 wt% of the polyimide precursor. The BET surface area of the TR 460 (680 m2 g−1) was significantly higher than that of the TDA1-APAF polyimide (260 m2 g−1) as determined by nitrogen adsorption at −196 °C. Heating TDA1-APAF for 30 min (TRC 460) resulted in a weight loss of 13.5 wt%, indicating full conversion to PBO and partial main-chain degradation. The TR 460 membrane displayed excellent O2 permeability of 311 Barrer coupled with an O2/N2 selectivity of 5.4 and CO2 permeability of 1328 Barrer with a CO2/CH4 selectivity of 27. Interestingly, physical aging over 150 days resulted in enhanced O2/N2 selectivity of 6.3 with an O2 permeability of 185 Barrer. The novel triptycene-based TR 460 PBO outperformed all previously reported APAF-polyimide-based PBOs with gas permeation performance close to recently reported polymers located on the 2015 O2/N2 upper bound. Based on this study, thermally-rearranged membranes from hydroxyl-functionalized triptycene-based polyimides are promising candidate membrane materials for air separation, specifically in applications where space and weight of membrane systems are of utmost importance such as nitrogen production for inert atmospheres in fuel lines and tanks on aircrafts and off-shore oil- or natural gas platforms. Mixed-gas permeation experiments also demonstrated good performance of the TR 460 membrane for natural gas sweetening with a CO2 permeability of ∼1000 Barrer and CO2/CH4 selectivity of 22 at a typical CO2 wellhead partial pressure of 10 bar.

  18. Hippocampal cholinergic interneurons visualized with the choline acetyltransferase promoter: anatomical distribution, intrinsic membrane properties, neurochemical characteristics, and capacity for cholinergic modulation

    Directory of Open Access Journals (Sweden)

    Feng eYi

    2015-03-01

    Full Text Available Release of acetylcholine (ACh in the hippocampus (HC occurs during exploration, arousal, and learning. Although the medial septum-diagonal band of Broca (MS-DBB is the major extrinsic source of cholinergic input to the HC, cholinergic neurons intrinsic to the HC also exist but remain poorly understood. Here, ChAT-tauGFP and ChAT-CRE/Rosa26YFP (ChAT-Rosa mice were examined in HC. The HC of ChAT-tauGFP mice was densely innervated with GFP-positive axons, often accompanied by large GFP-positive structures, some of which were Neurotrace/DAPI-negative and likely represent large axon terminals. In the HC of ChAT-Rosa mice, ChAT-YFP cells were Neurotrace-positive and more abundant in CA3 and dentate gyrus than CA1 with partial overlapping with calretinin/VIP. Moreover, an anti-ChAT antibody consistently showed ChAT immunoreactivity in ChAT-YFP cells from MS-DBB but rarely from HC. Furthermore, ChAT-YFP cells from CA1 stratum radiatum/stratum lacunosum moleculare (SR/SLM exhibited a stuttering firing phenotype but a delayed firing phenotype in stratum pyramidale (SP of CA3. Input resistance and capacitance were also different between CA1 SR/LM and CA3 SP ChAT-YFP cells. Bath application of ACh increased firing frequency in all ChAT-YFP cells; however, cholinergic modulation was larger in CA1 SR/SLM than CA3 SP ChAT-YFP cells. Finally, CA3 SP ChAT-YFP cells exhibited a wider AP half-width and weaker cholinergic modulation than YFP-negative CA3 pyramidal cells. Consistent with CRE expression in a subpopulation of principal cells, optogenetic stimulation evoked glutamatergic postsynaptic currents in CA1 SR/SLM interneurons. In conclusion, the presence of fluorescently labeled hippocampal cells common to both ChAT-Rosa and ChAT-tauGFP mice are in good agreement with previous reports on the existence of cholinergic interneurons, but both transgenic mouse lines exhibited unexpected anatomical features that departed considerably from earlier observations.

  19. Hippocampal "cholinergic interneurons" visualized with the choline acetyltransferase promoter: anatomical distribution, intrinsic membrane properties, neurochemical characteristics, and capacity for cholinergic modulation.

    Science.gov (United States)

    Yi, Feng; Catudio-Garrett, Elizabeth; Gábriel, Robert; Wilhelm, Marta; Erdelyi, Ferenc; Szabo, Gabor; Deisseroth, Karl; Lawrence, Josh

    2015-01-01

    Release of acetylcholine (ACh) in the hippocampus (HC) occurs during exploration, arousal, and learning. Although the medial septum-diagonal band of Broca (MS-DBB) is the major extrinsic source of cholinergic input to the HC, cholinergic neurons intrinsic to the HC also exist but remain poorly understood. Here, ChAT-tauGFP and ChAT-CRE/Rosa26YFP (ChAT-Rosa) mice were examined in HC. The HC of ChAT-tauGFP mice was densely innervated with GFP-positive axons, often accompanied by large GFP-positive structures, some of which were Neurotrace/DAPI-negative and likely represent large axon terminals. In the HC of ChAT-Rosa mice, ChAT-YFP cells were Neurotrace-positive and more abundant in CA3 and dentate gyrus than CA1 with partial overlap with calretinin/VIP. Moreover, an anti-ChAT antibody consistently showed ChAT immunoreactivity in ChAT-YFP cells from MS-DBB but rarely from HC. Furthermore, ChAT-YFP cells from CA1 stratum radiatum/stratum lacunosum moleculare (SR/SLM) exhibited a stuttering firing phenotype but a delayed firing phenotype in stratum pyramidale (SP) of CA3. Input resistance and capacitance were also different between CA1 SR/LM and CA3 SP ChAT-YFP cells. Bath application of ACh increased firing frequency in all ChAT-YFP cells; however, cholinergic modulation was larger in CA1 SR/SLM than CA3 SP ChAT-YFP cells. Finally, CA3 SP ChAT-YFP cells exhibited a wider AP half-width and weaker cholinergic modulation than YFP-negative CA3 pyramidal cells. Consistent with CRE expression in a subpopulation of principal cells, optogenetic stimulation evoked glutamatergic postsynaptic currents in CA1 SR/SLM interneurons. In conclusion, the presence of fluorescently labeled hippocampal cells common to both ChAT-tauGFP and ChAT-Rosa mice are in good agreement with previous reports on the existence of cholinergic interneurons, but both transgenic mouse lines exhibited unexpected anatomical features that departed considerably from earlier observations.

  20. Developing an Ear Prosthesis Fabricated in Polyvinylidene Fluoride by a 3D Printer with Sensory Intrinsic Properties of Pressure and Temperature

    OpenAIRE

    Ernesto Suaste-Gómez; Grissel Rodríguez-Roldán; Héctor Reyes-Cruz; Omar Terán-Jiménez

    2016-01-01

    An ear prosthesis was designed in 3D computer graphics software and fabricated using a 3D printing process of polyvinylidene fluoride (PVDF) for use as a hearing aid. In addition, the prosthesis response to pressure and temperature was observed. Pyroelectric and piezoelectric properties of this ear prosthesis were investigated using an astable multivibrator circuit, as changes in PVDF permittivity were observed according to variations of pressure and temperature. The results show that this pr...

  1. Intrinsic stability of ferroelectric and piezoelectric properties of epitaxial PbZr0.45Ti0.55O3 thin films on silicon in relation to grain tilt.

    Science.gov (United States)

    Houwman, Evert P; Nguyen, Minh D; Dekkers, Matthijn; Rijnders, Guus

    2013-08-01

    Piezoelectric thin films of PbZr0.45Ti0.55O3 were grown on Si substrates in four different ways, resulting in different crystalline structures, as determined by x-ray analysis. The crystalline structures were different in the spread in tilt angle and the in-plane alignment of the crystal planes between different grains. It is found that the deviations of the ferroelectric polarization loop from that of the ideal rectangular loop (reduction of the remanent polarization with respect to the saturation polarization, dielectric constant of the film, slanting of the loop, coercive field value) all scale with the average tilt angle. A model is derived based on the assumption that the tilted grain boundaries between grains affect the film properties locally. This model describes the observed trends. The effective piezoelectric coefficient d33,eff shows also a weak dependence on the average tilt angle for films grown in a single layer, whereas it is strongly reduced for the films deposited in multiple layers. The least affected properties are obtained for the most epitaxial films, i.e. grown on a SrTiO3 epitaxial seed layer, by pulsed laser deposition. These films are intrinsically stable and do not require poling to acquire these stable properties.

  2. Intrinsic stability of ferroelectric and piezoelectric properties of epitaxial PbZr0.45Ti0.55O3 thin films on silicon in relation to grain tilt

    Directory of Open Access Journals (Sweden)

    Evert P Houwman, Minh D Nguyen, Matthijn Dekkers and Guus Rijnders

    2013-01-01

    Full Text Available Piezoelectric thin films of PbZr0.45Ti0.55O3 were grown on Si substrates in four different ways, resulting in different crystalline structures, as determined by x-ray analysis. The crystalline structures were different in the spread in tilt angle and the in-plane alignment of the crystal planes between different grains. It is found that the deviations of the ferroelectric polarization loop from that of the ideal rectangular loop (reduction of the remanent polarization with respect to the saturation polarization, dielectric constant of the film, slanting of the loop, coercive field value all scale with the average tilt angle. A model is derived based on the assumption that the tilted grain boundaries between grains affect the film properties locally. This model describes the observed trends. The effective piezoelectric coefficient d33,eff shows also a weak dependence on the average tilt angle for films grown in a single layer, whereas it is strongly reduced for the films deposited in multiple layers. The least affected properties are obtained for the most epitaxial films, i.e. grown on a SrTiO3 epitaxial seed layer, by pulsed laser deposition. These films are intrinsically stable and do not require poling to acquire these stable properties.

  3. Scalar Curvature and Intrinsic Flat Convergence

    CERN Document Server

    Sormani, Christina

    2016-01-01

    Herein we present open problems and survey examples and theorems concerning sequences of Riemannian manifolds with uniform lower bounds on scalar curvature and their limit spaces. Examples of Gromov and of Ilmanen which naturally ought to have certain limit spaces do not converge with respect to smooth or Gromov-Hausdorff convergence. Thus we focus here on the notion of Intrinsic Flat convergence, developed jointly with Wenger. This notion has been applied successfully to study sequences that arise in General Relativity. Gromov has suggested it should be applied in other settings as well. We first review intrinsic flat convergence, its properties, and its compactness theorems, before presenting the applications and the open problems.

  4. Structure and intrinsic disorder in protein autoinhibition.

    Science.gov (United States)

    Trudeau, Travis; Nassar, Roy; Cumberworth, Alexander; Wong, Eric T C; Woollard, Geoffrey; Gsponer, Jörg

    2013-03-05

    Autoinhibition plays a significant role in the regulation of many proteins. By analyzing autoinhibited proteins, we demonstrate that these proteins are enriched in intrinsic disorder because of the properties of their inhibitory modules (IMs). A comparison of autoinhibited proteins with structured and intrinsically disordered IMs revealed that in the latter group (1) multiple phosphorylation sites are highly abundant; (2) splice variants occur in greater number than in their structured cousins; and (3) activation is often associated with changes in secondary structure in the IM. Analyses of families of autoinhibited proteins revealed that the levels of disorder in IMs can vary significantly throughout homologous proteins, whereas residues located at the interfaces between the IMs and inhibited domains are conserved. Our findings suggest that intrinsically disordered IMs provide advantages over structured ones that are likely to be exploited in the fine-tuning of the equilibrium between active and inactive states of autoinhibited proteins.

  5. Intrinsic dependence of the magnetic properties of CoFe{sub 2}O{sub 4} nanoparticles prepared via chemical methods with addition of chelating agents

    Energy Technology Data Exchange (ETDEWEB)

    Mendonça, E.C. [Núcleo de Pós-Graduação em Física, Campus Prof. José Aluísio de Campos, UFS, 49100-000 São Cristóvão, SE (Brazil); Tenório, Mayara A. [Departamento de Física, Campus Prof. Alberto Carvalho, UFS, 49500-000 Itabaiana, SE (Brazil); Mecena, S.G.; Zucolotto, B.; Silva, L.S. [Núcleo de Pós-Graduação em Física, Campus Prof. José Aluísio de Campos, UFS, 49100-000 São Cristóvão, SE (Brazil); Jesus, C.B.R. [Instituto de Física Gleb Wataghin, UNICAMP, C. P. 6165, 13083-970 Campinas, SP (Brazil); Meneses, C.T. [Núcleo de Pós-Graduação em Física, Campus Prof. José Aluísio de Campos, UFS, 49100-000 São Cristóvão, SE (Brazil); and others

    2015-12-01

    In this work, the effect of addition of different chelating agents on the magnetic properties of cobalt ferrite nanoparticles produced by the combining of both co-precipitation and hydrothermal methods is reported. The Rietveld analyses of X-ray diffraction patterns reveal that our samples are single phase (space group: Fd-3m) with small average sizes. The weight losses observed in the thermogravimetric measurements together with the M×H curves show that the organic contamination coming from chelating agent decomposition can give rise to misinterpretation of the magnetization measurements. Besides, analyses of the zero-field-cooled (ZFC) and field-cooled (FC) magnetization measurements and the M×H curves measured at room temperature allows us to state that both the average blocking temperature and particles size distribution are sensitive to the kind of chelating agent. - Highlights: Superparamagnetism. Chelating agents. Organic contamination.

  6. Probing the origin of 750 GeV diphoton excess with the precision measurements at the ILC

    Science.gov (United States)

    Bae, Kyu Jung; Hamaguchi, Koichi; Moroi, Takeo; Yanagi, Keisuke

    2016-08-01

    The recently reported diphoton excess at the LHC may imply the existence of a new resonance with a mass of about 750 GeV which couples to photons via loops of new charged particles. In this letter, we study the possibility to test such models at the ILC, paying attention to the new charged particles responsible for the diphoton decay of the resonance. We show that they affect the scattering processes e+e- → f f bar (with f denoting Standard Model fermions) at the ILC, which makes it possible to indirectly probe the new charged particles even if they are out of the kinematical reach. We also show that the discriminations of the diphoton models may be possible based on a study of the angular distributions of f f bar .

  7. Design and evaluation of a low-level RF control system analog/digital receiver for the ILC main Linacs

    Energy Technology Data Exchange (ETDEWEB)

    Mavric, Uros; Vidmar, Matjaz; Chase, Brian; /Fermilab

    2008-06-01

    The proposed RF distribution scheme for the two 15 km long ILC LINACs, uses one klystron to feed 26 superconducting RF cavities operating at 1.3 GHz. For a precise control of the vector sum of the signals coming from the SC cavities, the control system needs a high performance, low cost, reliable and modular multichannel receiver. At Fermilab we developed a 96 channel, 1.3 GHz analog/digital receiver for the ILC LINAC LLRF control system. In the paper we present a balanced design approach to the specifications of each receiver section, the design choices made to fulfill the goals and a description of the prototyped system. The design is tested by measuring standard performance parameters, such as noise figure, linearity and temperature sensitivity. Measurements show that the design meets the specifications and it is comparable to other similar systems developed at other laboratories, in terms of performance.

  8. Detection of Charged Higgs Bosons in e+e-(γγ) → t(b-)φ-Production at the ILC

    Institute of Scientific and Technical Information of China (English)

    HAN Jin-Zhong; LI Bing-Zhong

    2013-01-01

    In the context of the left-right twin Higgs (LRTH) model,we have studied the charged Higgs bosons production processes e+e-(γγ) → t(b-)φ-at the International Linear Collider (ILC).It is found that the cross sections of these two processes could reach a few fb with reasonable parameter values.With the yearly integrated luminosity of L =500 fb-1 expected at the ILC,one could collect hundreds up to thousands of charged Higgs events via these two processes.Therefore,our researches in this paper can help us search for charged Higgs bosons,and furthermore,to test the LRTH model.

  9. Design and evaluation of a low-level RF control system analog/digital receiver for the ILC main LINACs

    Energy Technology Data Exchange (ETDEWEB)

    Mavric, Uros [Fermilab, P.O. Box 500, 60510 Batavia, IL (United States)], E-mail: mavric@fnal.gov; Chase, Brian [Fermilab, P.O. Box 500, 60510 Batavia, IL (United States); Vidmar, Matjaz [Faculty of Electrical Engineering in Ljubljana, Trzaska 25, 1000 Ljubljana (Slovenia)

    2008-08-21

    The proposed RF distribution scheme for the two 15 km long ILC LINACs uses one klystron to feed 26 superconducting RF cavities operating at 1.3 GHz. For a precise control of the vector sum of the signals coming from the SC cavities, the control system needs a high-performance, low-cost, reliable and modular multichannel receiver. At Fermilab we developed a 96-channel, 1.3 GHz analog/digital receiver for the ILC LINAC LLRF control system. In this paper we present a balanced design approach to the specifications of each receiver section, the design choices made to fulfill the goals and a description of the prototyped system. The design is tested by measuring standard performance parameters, such as noise figure, linearity and temperature sensitivity. Measurements show that the design meets the specifications and it is comparable to other similar systems developed at other laboratories, in terms of performance.

  10. CrossRef Energy Reconstruction in a High Granularity Semi-Digital Hadronic Calorimeter for ILC Experiments

    CERN Document Server

    Mannai, S; Cortina, E; Laktineh, I

    2016-01-01

    Abstract: The Semi-Digital Hadronic CALorimeter (SDHCAL) is one of the two hadronic calorimeter options proposed by the International Large Detector (ILD) project for the future International Linear Collider (ILC) experiments. It is a sampling calorimeter with 48 active layers made of Glass Resistive Plate Chambers (GRPCs) and their embedded electronics. A fine lateral segmentation is obtained thanks to pickup pads of 1 cm2. This ensures the high granularity required for the application of the Particle Flow Algorithm (PFA) in order to improve the jet energy resolution in the ILC experiments. The performance of the SDHCAL technological prototype was tested successfully in several beam tests at CERN. The main point to be discussed here concerns the energy reconstruction in SDHCAL. Based on Monte Carlo simulation of the SDHCAL prototype using the GEANT4 package, we present different energy reconstruction methods to study the energy linearity and resolution of the detector response to single hadrons. In particula...

  11. Probing the origin of 750 GeV diphoton excess with the precision measurements at the ILC

    CERN Document Server

    Bae, Kyu Jung; Moroi, Takeo; Yanagi, Keisuke

    2016-01-01

    The recently reported diphoton excess at the LHC may imply the existence of a new resonance with a mass of about 750 GeV which couples to photons via loops of new charged particles. In this letter, we study the possibility to test such models at the ILC, paying attention to the new charged particles responsible for the diphoton decay of the resonance. We show that they affect the scattering processes $e^+e^- \\to f\\bar{f}$ (with $f$ denoting Standard Model fermions) at the ILC, which makes it possible to indirectly probe the new charged particles even if they are out of the kinematical reach. We also show that the discriminations of the diphoton models may be possible based on a study of the angular distributions of $f\\bar{f}$.

  12. Separating weak lensing and intrinsic alignments using radio observations

    CERN Document Server

    Whittaker, Lee; Battye, Richard A

    2015-01-01

    We discuss methods for performing weak lensing using radio observations to recover information about the intrinsic structural properties of the source galaxies. Radio surveys provide unique information that can benefit weak lensing studies, such as HI emission, which may be used to construct galaxy velocity maps, and polarized synchrotron radiation; both of which provide information about the unlensed galaxy and can be used to reduce galaxy shape noise and the contribution of intrinsic alignments. Using a proxy for the intrinsic position angle of an observed galaxy, we develop techniques for cleanly separating weak gravitational lensing signals from intrinsic alignment contamination in forthcoming radio surveys. Random errors on the intrinsic orientation estimates introduce biases into the shear and intrinsic alignment estimates. However, we show that these biases can be corrected for if the error distribution is accurately known. We demonstrate our methods using simulations, where we reconstruct the shear an...

  13. Developing an Ear Prosthesis Fabricated in Polyvinylidene Fluoride by a 3D Printer with Sensory Intrinsic Properties of Pressure and Temperature.

    Science.gov (United States)

    Suaste-Gómez, Ernesto; Rodríguez-Roldán, Grissel; Reyes-Cruz, Héctor; Terán-Jiménez, Omar

    2016-03-04

    An ear prosthesis was designed in 3D computer graphics software and fabricated using a 3D printing process of polyvinylidene fluoride (PVDF) for use as a hearing aid. In addition, the prosthesis response to pressure and temperature was observed. Pyroelectric and piezoelectric properties of this ear prosthesis were investigated using an astable multivibrator circuit, as changes in PVDF permittivity were observed according to variations of pressure and temperature. The results show that this prosthesis is reliable for use under different conditions of pressure (0 Pa to 16,350 Pa) and temperature (2 °C to 90 °C). The experimental results show an almost linear and inversely proportional behavior between the stimuli of pressure and temperature with the frequency response. This 3D-printed ear prosthesis is a promising tool and has a great potentiality in the biomedical engineering field because of its ability to generate an electrical potential proportional to pressure and temperature, and it is the first time that such a device has been processed by the additive manufacturing process (3D printing). More work needs to be carried out to improve the performance, such as electrical stimulation of the nervous system, thereby extending the purpose of a prosthesis to the area of sensory perception.

  14. Characterization of the antioxidant properties of pentaerithrityl tetranitrate (PETN)-induction of the intrinsic antioxidative system heme oxygenase-1 (HO-1).

    Science.gov (United States)

    Daiber, Andreas; Münzel, Thomas

    2010-01-01

    Organic nitrates are among the oldest and yet most commonly employed drugs in the chronic therapy of coronary artery disease and congestive heart failure. While they have long been used in clinical practise, our understanding of their mechanism of action and of their side effects remains incomplete. To date, the most commonly employed nitrates are isosorbide mononitrate (ISMN), isosorbide dinitrate (ISDN), and nitroglycerin (GTN). Another nitrate, pentaerithrityl tetranitrate (PETN), has long been employed in eastern European countries and is currently being reintroduced also in western countries. So far, PETN is the only organic nitrate in clinical use, which is devoid of induction of oxidative stress and related side-effects such as endothelial dysfunction and nitrate tolerance. Some of these effects are related to special pharmacokinetics of PETN, but upon chronic administration, PETN also induces antioxidative pathways at the genomic level, resulting in increased expression of heme oxygenase-1 (HO-1) and ferritin, both possessing highly protective properties. There is good experimental evidence that at least part of the beneficial profile of long-term PETN treatment is based on activation of the heme oxygenase-1/ferritin system.

  15. Developing an Ear Prosthesis Fabricated in Polyvinylidene Fluoride by a 3D Printer with Sensory Intrinsic Properties of Pressure and Temperature

    Directory of Open Access Journals (Sweden)

    Ernesto Suaste-Gómez

    2016-03-01

    Full Text Available An ear prosthesis was designed in 3D computer graphics software and fabricated using a 3D printing process of polyvinylidene fluoride (PVDF for use as a hearing aid. In addition, the prosthesis response to pressure and temperature was observed. Pyroelectric and piezoelectric properties of this ear prosthesis were investigated using an astable multivibrator circuit, as changes in PVDF permittivity were observed according to variations of pressure and temperature. The results show that this prosthesis is reliable for use under different conditions of pressure (0 Pa to 16,350 Pa and temperature (2 °C to 90 °C. The experimental results show an almost linear and inversely proportional behavior between the stimuli of pressure and temperature with the frequency response. This 3D-printed ear prosthesis is a promising tool and has a great potentiality in the biomedical engineering field because of its ability to generate an electrical potential proportional to pressure and temperature, and it is the first time that such a device has been processed by the additive manufacturing process (3D printing. More work needs to be carried out to improve the performance, such as electrical stimulation of the nervous system, thereby extending the purpose of a prosthesis to the area of sensory perception.

  16. Porous MnOx for low-temperature NH3-SCR of NOx: the intrinsic relationship between surface physicochemical property and catalytic activity

    Science.gov (United States)

    Shi, Jian-Wen; Gao, Chen; Liu, Chang; Fan, Zhaoyang; Gao, Ge; Niu, Chunming

    2017-06-01

    Three kinds of porous MnOx catalysts consisted of nanoparticles (about 6.5, 8.5, and 21 nm, respectively) were successfully prepared by three different methods, co-precipitation method (CP), citric acid method (CA), and hydrothermal method (HT), respectively. Their physicochemical properties were characterized by TEM, XRD, BET, XPS, H2-TPR, and NH3-TPD in detail, and their catalytic activities were evaluated by the selective catalytic reduction (SCR) of NOx with NH3 in the temperature range of 60 300 °C. The results showed that their catalytic activities decreased in the order of MnOx/HT > MnOx/CA > MnOx/CP in the region of 60-120 °C due to the dominant factor resulted from the reducibility of MnOx. In contrast, their catalytic activities declined in the order of MnOx/CA > MnOx/HT > MnOx/CP in the region of 180-300 °C, which can be attributed to the amount of acid sites on the surface of these catalysts. In the region of 120-180 °C, the as-prepared three catalysts exhibited high catalytic activity with 100% NOx conversion under a high gas hourly space velocity (GHSV) of 36,000 h-1. [Figure not available: see fulltext.

  17. A Study of the Impact of High Cross Section ILC Processes on the SiD Detector Design

    CERN Document Server

    Barklow, Timothy; Milke, Christopher; Schumm, Bruce; Schütz, Anne; Stanitzki, Marcel; Strube, Jan

    2016-01-01

    The SiD concept is one of two proposed detectors to be mounted at the interaction region of the International Linear Collider (ILC). A substantial ILC background arises from low transverse momentum $\\mathrm{e}^{+}\\mathrm{e}^{-}$ pairs created by the interaction of the colliding beams' electromagnetic fields. In order to provide hermeticity and sensitivity to beam targeting parameters, a forward Beamline Calorimeter (BeamCal) is being designed that will provide coverage down to 5 mrad from the outgoing beam trajectory, and intercept the majority of this pair background. Using the SiD simulation framework, the effect of this pair background on the SiD detector components, especially the vertex detector (VXD) and forward electromagnetic calorimeter (FCAL), is explored. In the case of the FCAL, backgrounds from Bhabha and two-photon processes are also considered. The consequence of several variants of the BeamCal geometry and ILC interaction region configuration are considered for both the vertex detector and Bea...

  18. Design of a current based readout chip and development of a DEPFET pixel prototype system for the ILC vertex detector

    Energy Technology Data Exchange (ETDEWEB)

    Trimpl, M.

    2005-12-15

    The future TeV-scale linear collider ILC (International Linear Collider) offers a large variety of precision measurements complementary to the discovery potential of the LHC (Large Hadron Collider). To fully exploit its physics potential, a vertex detector with unprecedented performance is needed. One proposed technology for the ILC vertex detector is the DEPFET active pixel sensor. The DEPFET sensor offers particle detection with in-pixel amplification by incorporating a field effect transistor into a fully depleted high-ohmic silicon substrate. The device provides an excellent signal-to-noise ratio and a good spatial resolution at the same time. To establish a very fast readout of a DEPFET pixel matrix with row rates of 20 MHz and more, the 128 channel CURO II ASIC has been designed and fabricated. The architecture of the chip is completely based on current mode techniques (SI) perfectly adapted to the current signal of the sensor. For the ILC vertex detector a prototype system with a 64 x 128 DEPFET pixel matrix read out by the CURO II chip has been developed. The design issues and the standalone performance of the readout chip as well as first results with the prototype system will be presented. (orig.)

  19. Probing Higgs-radion mixing in warped models through complementary searches at the LHC and the ILC

    CERN Document Server

    Frank, Mariana; Maitra, Ushoshi; Patra, Monalisa

    2016-01-01

    We consider the Higgs-radion mixing in the context of warped space extra dimensional models with custodial symmetry and investigate the prospects of detecting the mixed radion. Custodial symmetries allow the Kaluza-Klein excitations to be lighter, and protect Zbb to be in agreement with experimental constraints. We perform a complementary study of discovery reaches of the Higgs-radion mixed state at the 13 and 14 TeV LHC and at the 500 and 1000 GeV ILC. We carry out a comprehensive analysis of the most significant production and decay modes of the mixed radion in the 80 GeV - 1 TeV mass range, and indicate the parameter space that can be probed at the LHC and the ILC. There exists a region of the parameter space which can be probed, at the LHC, through the diphoton channel even for a relatively low luminosity of 50 fb^{-1}. The reach of the 4-lepton final state, in probing the parameter space is also studied in the context of 14 TeV LHC, for a luminosity of 1000 fb^{-1}. At the ILC, with an integrated luminos...

  20. Dedicated very front-end electronics for an ILC prototype hadronic calorimeter with SiPM read-out

    CERN Document Server

    de La Taille, C

    2008-01-01

    The SPIROC chip is a dedicated very front-end electronics for an ILC prototype hadronic calorimeter with Silicon photomultiplier (or MPPC) readout. This ASIC is due to equip a 10,000-channel demonstrator in 2009. SPIROC is an evolution of FLC_SiPM used for the ILC AHCAL physics prototype [1]. SPIROC was submitted in June 2007 and will be tested in September 2007. It embeds cutting edge features that fulfil ILC final detector requirements. It has been realized in 0.35m SiGe technology. It has been developed to match the requirements of large dynamic range, low noise, low consumption, high precision and large number of readout channels needed. SPIROC is an auto-triggered, bi-gain, 36-channel ASIC which allows to measure on each channel the charge from one photoelectron to 2000 and the time with a 100ps accurate TDC. An analogue memory array with a depth of 16 for each channel is used to store the time information and the charge measurement. A 12-bit Wilkinson ADC has been embedded to digitize the analogue memor...

  1. Triple gauge couplings and polarization at the ILC and leakage in a highly granular calorimeter

    Energy Technology Data Exchange (ETDEWEB)

    Marchesini, Ivan

    2011-12-15

    The work presented in this thesis was developed in the framework of detector R and D and physics studies for the International Linear Collider (ILC), a planned e{sup +}e{sup -} accelerator that will reach center of mass energies up to 500 GeV in its first stage. In the first part of the thesis a simultaneous measurement of longitudinal beam polarization and Triple Gauge Couplings (TGCs) at the ILC is implemented, using fully simulated Monte Carlo events. In order to perform such a measurement, semileptonic decays of the W-pairs at {radical}(s)=500 GeV are selected. Additionally, two techniques to measure the polarization alone are also compared. Assuming 80% longitudinal polarization for the electron beam and 60% for the positron beam, a statistical relative precision of better than 0.2% on the average beam polarization of both beams is achieved at an integrated luminosity of 250 fb{sup -1}. In the option of a low positron polarization of 30%, with an integrated luminosity of 500 fb{sup -1} the statistical relative precision on the average polarization is {proportional_to} 0.1% for the electron beam and {proportional_to} 0.35% for the positron beam. Three independent TGCs are fitted simultaneously with the polarization, without loosing sensitivity on the polarization. An absolute statistical uncertainty on the couplings is reached of the order of 10{sup -3}. The second part of the thesis presents the analysis of experimental data collected using the CALICE prototypes, during the 2007 test beam campaign at CERN. The complete setup of the experiment consisted of a silicon-tungsten electromagnetic calorimeter, an analog scintillator-steel hadron calorimeter and a scintillator-steel tail catcher. Events collected using pion beams in the energy range 8-100 GeV are selected and compared to the Monte Carlo simulations. While the leakage from the full setup is negligible, when removing the tail catcher information either partly or completely the energy loss becomes

  2. Trends in substrate hydroxylation reactions by heme and nonheme iron(IV)-oxo oxidants give correlations between intrinsic properties of the oxidant with barrier height.

    Science.gov (United States)

    de Visser, Sam P

    2010-01-27

    Iron(IV)-oxo species have been characterized in several nonheme enzymes and biomimetic systems and are efficient oxidants of aliphatic hydroxylation reactions. However, there appears to be a large variation in substrate hydroxylation ability by different iron(IV)-oxo oxidants due to the effect of the ligands bound to the metal. In this work, we have studied these indirect effects of ligands perpendicular (cis or equatorial) and opposite (trans or axial) to the iron(IV)-oxo group in heme and nonheme oxidants on the oxygenation capability of the oxidant. To this end, we have done a series of density functional theory calculations on the hydrogen atom abstraction of propene by a range of different iron(IV)-oxo oxidants that include heme and nonheme iron(IV)-oxo oxidants. We show that the hydrogen atom abstraction barrier of substrate hydroxylation correlates linearly with the strength of the Fe(III)O-H bond that is formed, i.e., BDE(OH), and that this value ranges by at least 20 kcal mol(-1) dependent on the cis- and trans-ligands attached to the metal. Thus, our studies show that ligands bound to the metal are noninnocent and influence the catalytic properties of the metal-oxo group dramatically due to involvement into the high-lying occupied and virtual orbitals. A general valence bond curve crossing model is set up that explains how the rate constant of hydrogen atom abstraction is proportional to the difference in energy of the C-H bond of the substrate that is broken and the O-H bond of the Fe(III)O-H complex that is formed, i.e., proportional to BDE(CH) - BDE(OH) or the reaction enthalpy. In addition, we show a correlation between the polarizability change and barrier height for the hydrogen atom abstraction reaction.

  3. Gaussian Intrinsic Entanglement

    Science.gov (United States)

    Mišta, Ladislav; Tatham, Richard

    2016-12-01

    We introduce a cryptographically motivated quantifier of entanglement in bipartite Gaussian systems called Gaussian intrinsic entanglement (GIE). The GIE is defined as the optimized mutual information of a Gaussian distribution of outcomes of measurements on parts of a system, conditioned on the outcomes of a measurement on a purifying subsystem. We show that GIE vanishes only on separable states and exhibits monotonicity under Gaussian local trace-preserving operations and classical communication. In the two-mode case, we compute GIE for all pure states as well as for several important classes of symmetric and asymmetric mixed states. Surprisingly, in all of these cases, GIE is equal to Gaussian Rényi-2 entanglement. As GIE is operationally associated with the secret-key agreement protocol and can be computed for several important classes of states, it offers a compromise between computable and physically meaningful entanglement quantifiers.

  4. Intrinsic Time Quantum Gravity

    CERN Document Server

    Yu, Hoi Lai

    2016-01-01

    Correct identification of the true gauge symmetry of General Relativity being 3d spatial diffeomorphism invariant(3dDI) (not the conventional infinite tensor product group with principle fibre bundle structure), together with intrinsic time extracted from clean decomposition of the canonical structure yields a self-consistent theory of quantum gravity. A new set of fundamental commutation relations is also presented. The basic variables are the eight components of the unimodular part of the spatial dreibein and eight SU(3) generators which correspond to Klauder's momentric variables that characterize a free theory of quantum gravity. The commutation relations are not canonical, but have well defined group theoretical meanings. All fundamental entities are dimensionless; and the quantum wave functionals are preferentially in the dreibein representation. The successful quantum theory of gravity involves only broad spectrum of knowledge and deep insights but no exotic idea.

  5. "Hall viscosity" and intrinsic metric of incompressible fractional Hall fluids

    OpenAIRE

    Haldane, F. D. M.

    2009-01-01

    The (guiding-center) "Hall viscosity" is a fundamental tensor property of incompressible ``Hall fluids'' exhibiting the fractional quantum Hall effect; it determines the stress induced by a non-uniform electric field, and the intrinsic dipole moment on (unreconstructed) edges. It is characterized by a rational number and an intrinsic metric tensor that defines distances on an ``incompressibility lengthscale''. These properties do not require rotational invariance in the 2D plane. The sign of ...

  6. Design of an Interaction Region with Head-On Collisions for the ILC

    Energy Technology Data Exchange (ETDEWEB)

    Appleby, R.; /Cockcroft Inst. Accel. Sci. Tech. /Manchester U.; Angal-Kalinin, D.; Jackson, F.; /Daresbury; Alabau-Pons, M .; Bambade, P.; Brossard, J.; Dadoun, O.; Rimbault, C.; /Orsay, LAL; Keller, L.; Nosochkov, Y.; Seryi, A.; /SLAC; Payet, J.; Napoly, O.; Rippon, C.; Uriot, D.; /DAPNIA, Saclay

    2006-07-12

    An interaction region (IR) with head-on collisions is considered as an alternative to the baseline configuration of the International Linear Collider (ILC) which includes two IRs with finite crossing-angles (2 and 20 mrad). Although more challenging for the beam extraction, the head-on scheme is favored by the experiments because it allows a more convenient detector configuration, particularly in the forward region. The optics of the head-on extraction is revisited by separating the e+ and e- beams horizontally, first by electrostatic separators operated at their LEP nominal field and then using a defocusing quadrupole of the final focus beam line. In this way the septum magnet is protected from the beamstrahlung power. Newly optimized final focus and extraction optics are presented, including a first look at post-collision diagnostics. The influence of parasitic collisions is shown to lead to a region of stable collision parameters. Disrupted beam and beamstrahlung photon losses are calculated along the extraction elements.

  7. Electroweak radiative corrections to $W^+W^-\\gamma$ production at the ILC

    CERN Document Server

    Chong, Chen; Ren-You, Zhang; Yu, Zhang; Liang-Wen, Chen; Lei, Guo

    2014-01-01

    We provide and discuss the precision predictions for the $W^+W^-\\gamma$ production at the ILC including the full electroweak (EW) one-loop corrections and high order initial state radiation (ISR) contributions in the Standard Model. The dependence of the leading order (LO) and EW corrected cross sections on the colliding energy is investigated. We find that the EW correction suppresses the LO cross section significantly, and the ISR effect beyond ${\\cal O}(\\alpha)$ is important near the threshold, but is negligible in the high energy region. We provide the LO and EW corrected distributions of the transverse momenta and rapidities of final $W^-$-boson and photon as well as the $W$-pair invariant mass. From the various kinematic distributions, we find that EW correction strongly depends on the final state phase space. We investigate the leptonic decays of the final W-boson pair by adopting the narrow width approximation (NWA), and find that the final produced photon and leptons can be well separated from each o...

  8. Dark current and radiation shielding studies for the ILC main linac

    Energy Technology Data Exchange (ETDEWEB)

    Mokhov, Nikolai V. [Fermilab; Rakhno, I. L. [Fermilab; Solyak, N. A. [Fermilab; Sukhanov, A. [Fermilab; Tropin, I. S. [Fermilab

    2016-12-05

    Electrons of dark current (DC), generated in high-gradient superconducting RF cavities (SRF) due to field emission, can be accelerated up to very high energies—19 GeV in the case of the International Linear Collider (ILC) main linac—before they are removed by focusing and steering magnets. Electromagnetic and hadron showers generated by such electrons can represent a significant radiation threat to the linac equipment and personnel. In our study, an operational scenario is analysed which is believed can be considered as the worst case scenario for the main linac regarding the DC contribution to the radiation environment in the main linac tunnel. A detailed modelling is performed for the DC electrons which are emitted from the surface of the SRF cavities and can be repeatedly accelerated in the high-gradient fields in many SRF cavities. Results of MARS15 Monte Carlo calculations, performed for the current main linac tunnel design, reveal that the prompt dose design level of 25 μSv/hr in the service tunnel can be provided by a 2.3-m thick concrete wall between the main and service ls.

  9. Optimization of the Low-Loss SRF Cavity for the ILC

    Energy Technology Data Exchange (ETDEWEB)

    Z. Li; L. Ge; K. Ko; L. Lee; C.-K. Ng; G. L. Schussman; L. Xiao; T. Higo; Y. Morozumi; K. Saito; P. Kneisel; J. S. Sekutowicz

    2007-08-01

    The Low-Loss shape cavity design has been proposed as a possible alternative to the baseline TESLA cavity design for the ILC. The advantages of this design over the TESLA cavity are its lower cryogenic loss, and higher achievable gradient due to lower surface fields. High gradient prototypes for such designs have been tested at KEK (ICHIRO) and JLab (LL). However, issues related to HOM damping and multipacting (MP) still need to be addressed. Preliminary numerical studies of the prototype cavities have shown unacceptable damping for some higher-order dipole modes if the typical TESLA HOM couplers are directly adapted to the design. The resulting wakefield will dilute the beam emittance thus reduces the machine luminosity. Furthermore, high gradient tests on a 9-cell prototype at KEK have experienced MP barriers although a single LL cell had achieved a high gradient. From simulations, MP activities are found to occur in the end-groups of the cavity. In this paper, we will present the optimization results of the end-groups for the Low-Loss shape for effective HOM damping and alleviation of multipacting. Comparisons of simulation results with measurements will also be presented.

  10. The Role of Beam polarization for Radiative Neutralino Production at the ILC

    CERN Document Server

    Dreiner, H K; Langenfeld, U; Dreiner, Herbert K.; Kittel, Olaf; Langenfeld, Ulrich

    2007-01-01

    We analyze the impact of electron and positron beam polarization on radiative neutralino production at the International Linear Collider (ILC). We focus on three different mSUGRA scenarios in turn at the Higgs strahlung threshold, the top pair production threshold, and at $\\sqrt{s} =500\\GeV$. In these scenarios at the corresponding $\\sqrt{s}$, radiative neutralino production is the only supersymmetric production mechanism which is kinematically allowed. The heavier neutralinos, and charginos as well as the sleptons, squarks and gluinos are too heavy to be pair produced. We calculate the signal cross section and also the Standard Model background from radiative neutrino production. For our scenarios, we obtain significances larger than 10 and signal to background ratios between 2% and 5%, if we have electron beam polarization $P_{e^-} = 0.0- 0.8$ and positron beam polarization $P_{e^+} = 0.0 - 0.3$. If we have electron beam polarization of $P_{e^-} = 0.9$, then the signal is observable with $P_{e^+} = 0.0$ but...

  11. The role of beam polarization for radiative neutralino production at the ILC

    Energy Technology Data Exchange (ETDEWEB)

    Dreiner, H.K.; Kittel, O.; Langenfeld, U. [Physikalisches Institut der Universitaet Bonn, Bonn (Germany)

    2008-03-15

    We analyze the impact of electron and positron beam polarization on radiative neutralino production at the international linear collider (ILC). We focus on three different mSUGRA scenarios in turn at the Higgsstrahlung threshold, the top pair production threshold, and at {radical}(s)=500 GeV. In these scenarios at the corresponding {radical}(s), radiative neutralino production is the only supersymmetric production mechanism that is kinematically allowed. The heavier neutralinos and charginos as well as the sleptons, squarks and gluinos are too heavy to be pair produced. We calculate the signal cross section and also the standard model background from radiative neutrino production. For our scenarios, we obtain significances larger than 10 and signal to background ratios between 2% and 5%, if we have electron beam polarization P{sub e}{sup -}=0.0-0.8 and positron beam polarization P{sub e}{sup +}=0.0-0.3. If we have electron beam polarization of P{sub e}{sup -}=0.9, then the signal is observable with P{sub e}{sup +}=0.0 but both the significance and the signal to background ratio are significantly improved for P{sub e}{sup +}=0.3. (orig.)

  12. The role of beam polarization for radiative neutralino production at the ILC

    Science.gov (United States)

    Dreiner, H. K.; Kittel, O.; Langenfeld, U.

    2008-03-01

    We analyze the impact of electron and positron beam polarization on radiative neutralino production at the international linear collider (ILC). We focus on three different mSUGRA scenarios in turn at the Higgs strahlung threshold, the top pair production threshold, and at sqrt{s} =500 GeV. In these scenarios at the corresponding sqrt{s}, radiative neutralino production is the only supersymmetric production mechanism that is kinematically allowed. The heavier neutralinos and charginos as well as the sleptons, squarks and gluinos are too heavy to be pair produced. We calculate the signal cross section and also the standard model background from radiative neutrino production. For our scenarios, we obtain significances larger than 10 and signal to background ratios between 2% and 5%, if we have electron beam polarization P_{e^-} = 0.0 0.8 and positron beam polarization P_{e^+} = 0.0 0.3. If we have electron beam polarization of P_{e^-} = 0.9, then the signal is observable with P_{e^+} = 0.0 but both the significance and the signal to background ratio are significantly improved for P_{e^+} = 0.3.

  13. Compact, Intelligent, Digitally Controlled IGBT Gate Drivers for a PEBB-Based ILC Marx Modulator

    Energy Technology Data Exchange (ETDEWEB)

    Nguyen, M.N.; Burkhart, C.; Olsen, J.J.; Macken, K.; /SLAC

    2010-06-07

    SLAC National Accelerator Laboratory has built and is currently operating a first generation prototype Marx klystron modulator to meet ILC specifications. Under development is a second generation prototype, aimed at improving overall performance, serviceability, and manufacturability as compared to its predecessor. It is designed around 32 cells, each operating at 3.75 kV and correcting for its own capacitor droop. Due to the uniqueness of this application, high voltage gate drivers needed to be developed for the main 6.5 kV and droop correction 1.7 kV IGBTs. The gate driver provides vital functions such as protection of the IGBT from over-voltage and over-current, detection of gate-emitter open and short circuit conditions, and monitoring of IGBT degradation (based on collector-emitter saturation voltage). Gate drive control, diagnostic processing capabilities, and communication are digitally implemented using an FPGA. This paper details the design of the gate driver circuitry, component selection, and construction layout. In addition, experimental results are included to illustrate the effectiveness of the protection circuit.

  14. RF and Data Acquisition Systems for Fermilab's ILC SRF Cavity Vertical Test Stand

    Energy Technology Data Exchange (ETDEWEB)

    Joseph P. Ozelis; Roger Nehring; Christiana Grenoble; Thomas J. Powers

    2007-06-01

    Fermilab is developing a facility for vertical testing of SRF cavities as part of a program to improve cavity performance reproducibility for the ILC. The RF system for this facility, using the classic combination of oscillator, phase detector/mixer, and loop amplifier to detect the resonant cavity frequency and lock onto the cavity, is based on the proven production cavity test systems used at Jefferson Lab for CEBAF and SNS cavity testing. The design approach is modular in nature, using commercial-off-the-shelf (COTS) components. This yields a system that can be easily debugged and modified, and with ready availability of spares. Data acquisition and control is provided by a PXI-based hardware platform in conjunction with software developed in the LabView programming environment. This software provides for amplitude and phase adjustment of incident RF power, and measures all relevant cavity power levels, cavity thermal environment parameters, as well as field emission-produced radiation. It also calculates the various cavity performance parameters and their associated errors. Performance during system commissioning and initial cavity tests will be presented.

  15. Estimation of radiation effects in the front-end electronics of an ILC electromagnetic calorimeter

    Science.gov (United States)

    Bartsch, V.; Postranecky, M.; Targett-Adams, C.; Warren, M.; Wing, M.

    2008-08-01

    The front-end electronics of the electromagnetic calorimeter of an International Linear Collider detector are situated in a radiation environment. This requires the effect of the radiation on the performance of the electronics, specifically FPGAs, to be examined. In this paper we study the flux, particle spectra and deposited doses at the front-end electronics of the electromagnetic calorimeter of a detector at the ILC. We also study the occupancy of the electromagnetic calorimeter. These estimates are compared with measurements, e.g. of the radiation damage of FPGAs, done elsewhere. The outcome of the study shows that the radiation doses and the annual flux is low enough to allow today's FPGAs to operate. The Single Event Upset rate, however, lies between 14 min and 12 h depending on the FPGA used and therefore needs to be considered in the design of the data acquisition system of the electromagnetic calorimeter. The occupancy is about 0.002 per bunch train not taking into account the effect of noise which depends on the choice of the detector.

  16. Strategy to measure the Higgs mass, width and invisible decays at ILC

    CERN Document Server

    Richard, F; Bambade, Philip; Richard, Francois

    2007-01-01

    This document is meant to provide semi-quantitative arguments to evaluate the luminosity needed at ILC to achieve a precise measurement of the Higgs mass, width and invisible decays. It is shown that for mH=120 GeV, one can save an order of magnitude on the luminosity needed to achieve a given precision on the Higgs mass, as compared to what can be obtained at \\sqrt s=350 GeV, by running near threshold. Since the recoil mass resolution near threshold is independent of the Higgs mass, one can also access the Higgs width for masses above 170 GeV. This strategy of running just above threshold is also optimal to measure or set upper limits on the Higgs invisible branching ratio. Two MSSM scenarios are presented to illustrate the potential interest of an optimized recoil mass resolution. A simplified description of the various experimental mechanisms affecting this type of measurement is presented: detector resolution for leptons and jets, luminosity and beamstrahlung energy dependence, initial and final radiation...

  17. Intrinsic Angular Momentum of Light.

    Science.gov (United States)

    Santarelli, Vincent

    1979-01-01

    Derives a familiar torque-angular momentum theorem for the electromagnetic field, and includes the intrinsic torques exerted by the fields on the polarized medium. This inclusion leads to the expressions for the intrinsic angular momentum carried by the radiation traveling through a charge-free medium. (Author/MA)

  18. Time generated by intrinsic observers

    CERN Document Server

    Svozil, Karl

    2009-01-01

    We shortly review the construction of knowledge by intrinsic observers. Intrinsic observers are embedded in a system and are inseparable parts thereof. The intrinsic viewpoint has to be contrasted with an extrinsic, "God's eye" viewpoint, from which the system can be observed externally without in any way changing it. This epistemological distinction has concrete, formalizable consequences. One consequence is the emergence of "complementarity" for intrinsic observers, even if the underlying system is totally deterministic (computable). Another consequence is the appearence of time and inertial frames for intrinsic observers. The necessary operational techniques are developed in the context of Cellular Automata. We finish with a somewhat speculative question. Given space-time frames generated by clocks which use sound waves for synchronization; why could supersonic travel not cause time paradoxes?

  19. Full simulation study of the top Yukawa coupling at the ILC at $\\sqrt{s}$ = 1 TeV

    CERN Document Server

    Price, Tony; Strube, Jan; Tanabe, Tomohiko

    2015-01-01

    We present a study of the expected precision for measurement of the top Yukawa coupling, yt, in e+e- collisions at a center-of-mass energy of 1 TeV and assuming a beam polarization of P (e-, e+) = (-0.8,+0.2). Independent analyses of ttH final states containing at least six hadronic jets are performed, based on detailed simulations of SiD and ILD, the two candidate detector concepts for the ILC. We estimate that a statistical precision of yt of 4% can be obtained with an integrated luminosity of 1 $\\mathrm{ab}^{-1}$.

  20. PHOENIX IB IL_AI_8/SF模板在ILC200UNI上的应用

    Institute of Scientific and Technical Information of China (English)

    马新; 田振云; 张振锋; 王怀杰

    2008-01-01

    本文介绍了菲尼克斯电气(PHOENIX)模拟量输入IB IL_AI_8/SF-PAC模块的功能,通过实例分析,阐述了在PC WORX编程环境里,通过功能块IL_AI_8_v2如何实现IL_AI_8/SF模板在ILC 200UNI PLC控制系统上的应用。

  1. Sensitivity on the Dipole Moments of the τ-Neutrino at e+e- Colliders: ILC and CLIC

    Directory of Open Access Journals (Sweden)

    A. Gutiérrez-Rodríguez

    2014-01-01

    Full Text Available We study the sensitivity on the anomalous magnetic and electric dipole moments of the τ-neutrino at a high-energy and high-luminosity linear electron positron collider, such as the ILC or CLIC, through the reaction e+e-→νν̅γ. We obtain limits on the dipole moments at the future linear colliders energies. For integrated luminosities of 500 fb−1 and center of mass energies between 0.5 and 3 TeV, the future e+e- colliders may improve the existing limits by two or three orders of magnitude.

  2. Recent progress on intrinsic charm

    Science.gov (United States)

    Hobbs, T. J.

    2017-03-01

    Over the past ˜10 years, the topic of the nucleon's nonperturbative or intrinsic charm (IC) content has enjoyed something of a renaissance, largely motivated by theoretical developments involving quark modelers and PDF-fitters. In this talk I will briefly describe the importance of intrinsic charm to various issues in high-energy phenomenology, and survey recent progress in constraining its overall normalization and contribution to the momentum sum rule of the nucleon. I end with the conclusion that progress on the side of calculation has now placed the onus on experiment to unambiguously resolve the proton's intrinsic charm component.

  3. Intrinsic time geometrodynamics: explicit examples

    CERN Document Server

    Lin, Huei-Chen

    2016-01-01

    Intrinsic time quantum geometrodynamics resolved `the problem of time' and bridged the deep divide between quantum mechanics and canonical quantum gravity with a Schrodinger equation which describes evolution in intrinsic time variable. In this formalism, Einstein's general relativity is a particular realization of a wider class of theories. Explicit classical black hole and cosmological solutions and the motion of test particles are derived and analyzed in this work in the context of constant three-curvature solutions in intrinsic time geometrodynamics; and we exemplify how this formalism yields results which agree with the predictions of Einstein's theory.

  4. Updated Study of a Precision Measurement of the W Mass from a Threshold Scan Using Polarized $\\rm{e}^-$ and $\\rm{e}^+$ at ILC

    CERN Document Server

    Wilson, Graham W

    2016-01-01

    An updated study of measuring the W mass from a polarized threshold scan at ILC is presented with an emphasis on evaluating scan strategies that control experimental systematics. Highly longitudinally polarized beams of electrons and positrons such as are feasible at ILC offer significant advantages in terms of statistical power and in-situ control of background. Eventual experimental precision of around 2 MeV can be envisaged from this technique. Further work on both the accelerator design and theoretical uncertainties will likely be needed to take full advantage of this opportunity.

  5. Improving the pair separation of WW/ZZ at the ILC by consideration of photon radiation in kinematic fits; Verbesserung der WW/ZZ-Unterscheidung am ILC durch Beruecksichtigung von Photonabstrahlung in kinematischen Fits

    Energy Technology Data Exchange (ETDEWEB)

    Beckmann, Moritz

    2010-04-15

    The International Linear Collider (ILC) is intended for high precision measurements. This places enormous demands on detector precision in the ongoing detector development program. Precision can be further improved by application of a kinematic fit to the data, forcing energy and momentum conservation. However, this requires all energies and momenta to be considered. Initial state radiation and beamstrahlung are two processes which emit photons predominantly in the beam direction and which escape detection. Due to higher center-of-mass energy and stronger focussing of the beam, these processes will have more impact at the ILC than at earlier colliders. This thesis investigates the effects of these processes on kinematic fits at the example of the separation of events with WW/ZZ pair production events. Different approaches in consideration of these processes are pointed out. A kinematic fit was performed on a sample of simulated e{sup +}e{sup -} {yields} u anti dd anti u events, forcing energy and momentum conservation and equal boson masses. It is shown that 25% more events can be covered in this fit, if photon radiation is taken into consideration using a basic approximation of the momentum spectrum of the photons. This method obtains even a further increase in resolution. Thus, a mass resolution of 1.9 GeV (without decay width) can be obtained. (orig.)

  6. Applications of scanning probe microscopy in intrinsically conducting polymer research

    Institute of Scientific and Technical Information of China (English)

    YANG Tao; NIU Li; LI Zhuang; DONG Shaojun

    2007-01-01

    The applications of scanning probe microscopy(SPM)in intrinsically conducting polymer research is briefly reviewed,including morphology observation,nanofabrication,microcosmic electrical property measurements,electrochemistry researches,in-situ measurements of film thickness change,and so on.At the same time,some important variations of SPM and the related techniques are briefly introduced.Finally,the future development of SPM in the study of intrinsically conducting polymers is prospected.

  7. Intrinsic motivation and learning dynamics

    CERN Document Server

    Zgonnikov, Arkady

    2013-01-01

    We investigate the effects of intrinsic motivation on the dynamics of learning processes. We construct a simple model of a single agent adapting to unknown environment. Performing a repeated choice between a number of initially unexplored alternatives, the agent gains rewards for each selected alternative and in doing so gradually comprehends the environment. In our model the agent choice is governed by two stimuli. The traditional extrinsic motive inclines the agent to maximize the cumulative payoff throughout the process, while the second, intrinsic one, biases the agent towards the novel options that she inherently likes. We show that the intrinsic motivation can induce an instability and periodic dynamics of the learning process which is always stationary in the case of selfish, rational agent. Interestingly, the opposite effect can arise as well: when the impact of intrinsic motivation on the agent choice is strong, the equiprobable choice equilibrium strategy becomes stable. Based on the presented resul...

  8. Nanostructured intrinsically conducting polymers formed by electrochemical synthesis

    OpenAIRE

    Gvozdenović, Milica; Jugović, Branimir; id_orcid 0000-0002-5331-6354; Grgur, Branimir; id_orcid 0000-0003-4684-9053

    2016-01-01

    Due to unique properties of intrinsically conducting polymers (ICP) such as: electrical conductivity, reversible electrochemistry, optical activity, biocompatibility, environmental and corrosion stability, they still represent a base for both theoretical and practical studies. The mentioned properties open up possibilities for practical application in the field of electrochemical systems for energy storage and conversion, sensors, biosensors, antistatic coatings, magnetic shielding, active co...

  9. Harmonic structures and intrinsic torsion

    DEFF Research Database (Denmark)

    Conti, Diego; Madsen, Thomas Bruun

    2015-01-01

    We discuss the construction of Sp(2)Sp(1)-structures whose fundamental form is closed. In particular, we find 10 new examples of 8-dimensional nilmanifolds that admit an invariant closed 4-form with stabiliser Sp(2) Sp(1). Our constructions entail the notion of SO(4)-structures on 7-manifolds. We...... present a thorough investigation of the intrinsic torsion of such structures, leading to the construction of explicit Lie group examples with invariant intrinsic torsion....

  10. Harmonic structures and intrinsic torsion

    DEFF Research Database (Denmark)

    Conti, Diego; Madsen, Thomas Bruun

    We discuss the construction of 8-manifolds with harmonic Sp(2)Sp(1)-structures. In particular, we find 10 new examples of nilmanifolds that admit a closed 4-form Omega whose stabiliser is Sp(2)Sp(1). Our constructions entail the notion of SO(4)-structures on 7-manifolds. We present a thorough inv...... investigation of the intrinsic torsion of such structures; in addition to the construction of harmonic structures, this analysis leads to explicit Lie group examples with invariant intrinsic torsion....

  11. Validation of a new highly standardised, lab-independent whole-blood leukocyte function assay for clinical trials (ILCS).

    Science.gov (United States)

    Schmolz, M; Hurst, T L; Bailey, D M; Powell, J R; Forsey, R J; Thompson, J M; Williams, C; Pawelec, G

    2004-04-01

    Physical stress induced in healthy volunteers by the Loughborough intermittent shuttle test (LIST) was used to validate a newly developed whole-blood cell culture system (Instant leukocyte culture system (ILCS). Exercise induced immune modulation was investigated through measurement of cytokine levels after activating leukocytes in peripheral blood ex vivo using the physiologic stimulant lipopolysaccharide (LPS). LPS induced production of three different cytokines, interferon gamma (IFNgamma), interleukin-6 (IL-6), and interleukin-10 (IL-10). IFNgamma levels were significantly decreased (P = 0.02 and P = 0.001 ) and IL-10 levels significantly increased (P= 0.04 and 0.03) after exercise. LPS induced IL-6 production was only marginally further increased by exercise. In conclusion, the ILCS system provided a reliable ex vivo method, showing common as well as subject specific features in the time course of the immune modulation caused by the LIST protocol. This system will be useful for studies of the elderly, where cytokine standardisation is notoriously difficult.

  12. Neutral Higgs Boson Pair-Production and Trilinear Self-Couplings in the MSSM at ILC and CLIC Energies

    CERN Document Server

    Gutiérrez-Rodríguez, A; Sampayo, O A

    2009-01-01

    We study pair-production as well as the triple self-couplings of the neutral Higgs bosons of the Minimal Supersymmetric Standard Model (MSSM) at the Future International Linear $e^{+}e^{-}$ Collider (ILC) and Compact Linear Collider (CLIC). The analysis is based on the reactions $e^{+}e^{-}\\to b \\bar b h_ih_i, t \\bar t h_ih_i$ with $h_i=h, H, A$. We evaluate the total cross-section for both $b\\bar bh_ih_i$, $t\\bar th_ih_i$ and calculate the total number of events considering the complete set of Feynman diagrams at tree-level. We vary the triple couplings $\\kappa\\lambda_{hhh}$, $\\kappa\\lambda_{Hhh}$, $\\kappa\\lambda_{hAA}$, $\\kappa\\lambda_{HAA}$, $\\kappa\\lambda_{hHH}$ and $\\kappa\\lambda_{HHH}$ within the range $\\kappa=-1$ and +2. The numerical computation is done for the energies expected at the ILC with a center-of-mass energy 500, 1000, 1600 $GeV$ and a luminosity 1000 $fb^{-1}$. The channels $e^{+}e^{-}\\to b \\bar b h_ih_i$ and $e^{+}e^{-}\\to t \\bar t h_ih_i$ are also discussed to a center-of-mass energy of 3...

  13. SIMULATION OF NEUTRON BACKGROUNDS FROM THE ILC EXTRACTION LINE BEAM DUMP

    Energy Technology Data Exchange (ETDEWEB)

    Darbha, S; Keller, L.; Maruyama, T.

    2008-01-01

    The operation of the International Linear Collider (ILC) as a precision measurement machine is dependent upon the quality of the charge-coupled device (CCD) silicon vertex detector. An integrated fl ux of 1010 neutrons/cm2 incident upon the vertex detector will degrade its performance by causing displacement damage in the silicon. One source of the neutron background arises from the dumping of the spent electron and positron beams into the extraction line beam dumps. The Monte Carlo program FLUKA was used to simulate the collision of the electron beam with the dump and to determine the resulting neutron fl ux at the interaction point (IP). A collimator and tunnel were added and their effect on the fl ux was analyzed. A neutron source was then generated and directed along the extraction line towards a model of the vertex detector to determine the neutron fl ux in its silicon layers. Models of the beampipe and BeamCal, a silicon-tungsten electromagnetic calorimeter in the very forward region of the detector, were placed in the extraction line and their effects on scattering were studied. The IP fl uence was determined to be 3.7x1010 +/- 2.3x1010 neutrons/cm2/year when the tunnel and collimator were in place, with no appreciable increase in statistics when the tunnel was removed. The BeamCal was discovered to act as a collimator by signifi cantly impeding the fl ow of neutrons towards the detector. The majority of damage done to the fi rst layer of the detector was found to come from neutrons with a direct line of sight from the fi rst extraction line quadrupole QDEX1, with only a small fraction scattering off of the beampipe and into the detector. The 1 MeV equivalent neutron fl uence was determined to be 9.3x108 neutrons/cm2/year from the electron beam alone. The two beams collectively contribute double to this fl uence, which is 19% of the threshold value in one year. Future work will improve the detector model and other sources of neutron backgrounds will be

  14. 急诊专科护士核心能力评价体系内在品质的验证研究%Evaluation system of core competence for emergency nurse specialist: testing of intrinsic properties

    Institute of Scientific and Technical Information of China (English)

    樊落; 席淑华

    2011-01-01

    Objective To establish a system evaluating core competence for emergency nurse specialist (ENS). Methods The Delphi technique and Analytic Hierarchy Process were used to develop the evaluation system of core competence for ENS. Then the evaluation system was formulated into self-reported questionnaire and was filled out by 138 ENSs to test its intrinsic properties. Results The overall Cronbach's α coefficient for the evaluation system was 0.966, with those of 5 domains ranging from 0. 508 to 0. 972;the correlation coefficient of the 5 level-1 indicators with the total evaluation system ranged from 0. 701 to 0.886(P<0.05 for all);contrast-group validity of 15 out of 16 level-2 indicators showed statistical differences (P<0.05 for all). Conclusion The evaluation system can be used to test core competence of ENS for its good reliability, validity and contrast-group validity. And it provides reference for training and evaluating ENSs for nursing managers.%目的 建立能客观评价急诊专科护士核心能力的评价体系.方法 以通过Delphi法和层次分析法建立的急诊专科护士核心能力评价体系(下称评价体系)为依据编制自评式问卷,采用此问卷对138名急诊专科护士进行调查,根据调查结果对评价体系的内在品质进行检验.结果评价体系的Cronbach′s α系数为0.966,5个一级指标的Cronbach′s α系数为0.508~0.972;一级指标与评价体系的相关系数r值为0.701~0.886(均P<0.05);16个二级指标区分度检验,15个差异有统计学意义(均P<0.05).结论 评价体系有较好的信度、效度和区分度,可用于急诊专科护士核心能力的评价;护理管理者可将其作为培养和评价急诊专科护士核心能力的参考依据.

  15. Probing Quasar Winds Using Intrinsic Narrow Absorption Lines

    Science.gov (United States)

    Culliton, Christopher S.; Charlton, Jane C.; Eracleous, Michael; Roberts, Amber; Ganguly, Rajib; Misawa, Toru; Muzahid, Sowgat

    2017-01-01

    Quasar outflows are important for understanding the accretion and growth processes of the central black hole. Furthermore, outflows potentially have a role in providing feedback to the galaxy, and halting star formation and infall of gas. The geometry and density of these outflows remain unknown, especially as a function of ionization and velocity. Having searched ultraviolet spectra at both high redshift (VLT/UVES; 1.4physically associated with) the quasar. We identify intrinsic NALs with a wide range of properties, including ejection velocity, coverage fraction, and ionization level. We also consider the incidence of intrinsic absorbers as a function of quasar properties (optical, radio and X-ray fluxes), and find that radio properties and quasar orientation are influential in determining if a quasar is likely to host an intrinsic system. We find that there is a continuum of properties within the intrinsic NAL sample, rather than discrete families, ranging from partially covered CIV systems with black Lya and with a separate low ionization gas phase to partially covered NV systems with partially covered Lya and without detected low ionization gas. Additionally, we construct a model describing the spatial distributions, geometries, and varied ionization structures of intrinsic NALs.

  16. Intrinsic subtypes and tumor grades in breast cancer are associated with distinct 3-D power Doppler sonographic vascular features

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Yeun-Chung [Department of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 10041, Taiwan, ROC (China); Huang, Yao-Sian [Department of Computer Science and Information Engineering, National Taiwan University, Taipei 10617, Taiwan, ROC (China); Huang, Chiun-Sheng [Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 10041, Taiwan, ROC (China); Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei 10617, Taiwan, ROC (China); Chen, Jeon-Hor [Center for Functional Onco-Imaging and Department of Radiological Science, University of California Irvine, California, CA 92868 (United States); Department of Radiology, E-Da Hospital and I-Shou University, Kaohsiung 82445, Taiwan, ROC (China); Chang, Ruey-Feng, E-mail: rfchang@csie.ntu.edu.tw [Department of Computer Science and Information Engineering, National Taiwan University, Taipei 10617, Taiwan, ROC (China); Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei 10617, Taiwan, ROC (China)

    2014-08-15

    Purpose: This study aimed to investigate the three-dimensional (3-D) power Doppler ultrasonographic (PDUS) vascular features of breast carcinoma according to intrinsic subtypes, nodal stage, and tumor grade. Materials and methods: Total 115 receiving mastectomy breast carcinomas (mean size, 2.5 cm; range, 0.7–6.5 cm), including 102 invasive ductal carcinomas (IDC), 10 ductal carcinomas in situ (DCIS), and 3 invasive lobular carcinomas (ILC) diagnosed after mastectomy, were used in this retrospective study. Sixty IDC had nodal status and histopathologic tumor grades available for analysis. Vascular features, including number of vascular trees (NV), longest path length (LPL), total vessel length (TVL), number of bifurcations (NB), distance metric (DM), inflection count metric (ICM), vessel diameter (VD), and vessel-to-volume ratio (VVR) were extracted using 3-D thinning method. The Mann–Whitney U test, Student's t-test, one-way ANOVA, and Kruskal–Wallis test were performed as appropriate. Results: There was no significant difference of vascular features among IDC, DCIS and ILC. Except VD, vascular features in luminal type were significantly lower compared to HER2-enriched or triple negative types (p < 0.05). Compared to ER+ (estrogen receptor positive) tumors, all features in ER− (estrogen receptor negative) tumors were significantly higher (p < 0.01). Despite some significantly higher vascular features in high grade IDC compared to low and intermediate grade, there was no significant correlation between vascular features and nodal stages. Conclusion: Differences in 3-D PDUS vascular features among intrinsic types of IDC are attributed to their ER status. Vascular features extracted by 3-D PDUS correlate with tumor grades but not nodal stage in IDC.

  17. Infinity in Logic and Computation: International Conference, ILC 2007, Cape Town, South Africa, November 3-5, 2007: Revised selected papers

    NARCIS (Netherlands)

    M. Archibald; V. Brattka; V. Goranko; B. Löwe

    2009-01-01

    Edited in collaboration with FoLLI, the Association of Logic, Language and Information, this volume constitutes a selection of papers presented at the Internatonal Conference on Infinity in Logic and Computation, ILC 2007, held in Cape Town, South Africa, in November 2007. The 7 revised papers prese

  18. Probing the Lightest New Gauge Boson BH in the Littlest Higgs Model via Processes γγ→f(-f)BH at ILC

    Institute of Scientific and Technical Information of China (English)

    HAN Yin-Lu; WANG Xue-Lei; GUO Hai-Rui; LIU Su-Zhen; ZHANG Yue; ZENG Qing-Guo; ZHANG Jing-Shang; JIN Zhen-Lan

    2008-01-01

    The neutral gauge boson BH with the mass of hundreds GeV is the lightest particle predicted by the littlest Higgs (LH) model, and such particle should be the first signal of the LH model at the planed ILC if it exists indeed. In this paper, we study some processes of the BH production associated with the fermion pair at the ILC, i.e., γγ→ffSH.The studies show that the most promising processes to detect BH among γγ→ffBH are γγ→l'+ l'- BH (l' = e, μ),and they can produce the sufficient signals in most parameter space preferred by the electroweak precision data at the ILC. On the other hand, the signal produced via the certain BH decay modes is typical and such signal can be easily identified from the SM background. Therefore, BH, the lightest gauge boson in the LH model, would be detectable at the photon eollider realized at the ILC.

  19. Performance studies of a time projection chamber at the ILC and search for lepton flavour violation at HERA II

    Energy Technology Data Exchange (ETDEWEB)

    Janssen, M.E.

    2008-05-15

    It is expected, that new physics beyond the Standard Model can be discovered in the energy range of 1TeV. One of the next projects in high energy physics will be a linear collider. A proposal for such a machine is the International Linear Collider (ILC), where electrons and positrons are brought to collision with a centre of mass energy up to 500 GeV with the possibility to upgrade it to 1 TeV. The precision measurement of this new physics sets high requirements on the performance of the detector at the ILC. As the main tracking device for a detector at the ILC, a Time Projection Chamber (TPC) has been proposed. To reach these requirements a new amplification techniques based on Micro Pattern Gas Detectors (MPGD) is under investigation. In this thesis, data are analysed, that were taken using the prototype MediTPC, whose amplification system is based on Gas Electron Multipliers (GEM). Different magnetic fields of up to 4 T, two gas mixtures and differed arrangement of the pads have also been investigated. The main part of this thesis deals with the study of the performance of two different approaches to determine track parameters. A new method based on a likelihood fit of the expected charge to the measured one is compared to a traditional approach using reconstructed space points and a {chi}{sup 2} minimisation technique. Different aspects such as the performance in the presence of non working channels and the angular dependency are investigated. Finally the determined spatial resolution (in the r{phi}-plane) is presented. At zero drift length a resolution of the order of 100 {mu}m can be achieved. In the second part of this thesis the results of a search for lepton flavour violation mediated by leptoquarks is presented. Data of electron-proton collisions with a centre-of-mass energy of 320 GeV taken with the H1 experiment are investigated. The analysis concentrates of the e{sup -}p data of the HERAII phase, which were taken in the years 2004-2006. They correspond

  20. High intrinsic energy resolution photon number resolving detectors

    CERN Document Server

    Lolli, L; Portesi, C; Monticone, E; Rajteri, M

    2013-01-01

    Transition Edge Sensors (TESs) are characterized by the intrinsic figure of merit to resolve both the energy and the statistical distribution of the incident photons. These properties lead TES devices to become the best single photon detector for quantum technology experiments. For a TES based on titanium and gold has been reached, at telecommunication wavelength, an unprecedented intrinsic energy resolution (0.113 eV). The uncertainties analysis of both energy resolution and photon state assignment has been discussed. The thermal properties of the superconductive device have been studied by fitting the bias curve to evaluate theoretical limit of the energy resolution.

  1. Intrinsic energy partition in fission

    Directory of Open Access Journals (Sweden)

    Mirea M.

    2013-03-01

    Full Text Available The intrinsic energy partition between two complementary fission fragments is investigated microscopically. The intrinsic excitation energy of fission fragments is dynamically evaluated in terms of the time-dependent pairing equations. These equations are corroborated with two conditions. One of them fixes the number of particles and the other separates the pairing active spaces associated to the two fragments in the vicinity of the scission configuration. The excitation energy in a wide distribution of fission fragments is calculated for the 234U parent nucleus.

  2. Rotating pigment cells exhibit an intrinsic chirality.

    Science.gov (United States)

    Yamanaka, Hiroaki; Kondo, Shigeru

    2015-01-01

    In multicellular organisms, cell properties, such as shape, size and function are important in morphogenesis and physiological functions. Recently, 'cellular chirality' has attracted attention as a cellular property because it can cause asymmetry in the bodies of animals. In recent in vitro studies, the left-right bias of cellular migration and of autonomous arrangement of cells under some specific culture conditions were discovered. However, it is difficult to identify the molecular mechanism underlying their intrinsic chirality because the left-right bias observed to date is subtle or is manifested in the stable orientation of cells. Here, we report that zebrafish (Danio rerio) melanophores exhibit clear cellular chirality by unidirectional counterclockwise rotational movement under isolated conditions without any special settings. The chirality is intrinsic to melanophores because the direction of the cellular rotation was not affected by the type of extracellular matrix. We further found that the cellular rotation was generated as a counter action of the clockwise movement of actin cytoskeleton. It suggested that the mechanism that directs actin cytoskeleton in the clockwise direction is pivotal for determining cellular chirality.

  3. Intrinsic thermoelectric power of group VB metals

    Directory of Open Access Journals (Sweden)

    Gunadhor Singh Okram

    2012-03-01

    Full Text Available We have reinvestigated the thermopower of group VB metals in polycrystalline forms in the temperature range of 6-300K, taking into account the critical nature of the sample surface and heat treatment especially for niobium. Strikingly small magnitude, negative sign, phonon drag dip and superconductivity not reported previously were observed in surface-cleaned single crystalline Nb. However, while thermopower magnitudes are small, mixed signs were found in the polycrystalline V, Nb and Ta samples. These properties were therefore interpreted as their intrinsic properties and were briefly discussed taking into account of the existing theory by fitting also the data that give the Fermi energies of 10.94 eV, 5.08 eV and 1.86eV, respectively.

  4. First samples of Ti and Nb tubes explosion welding joint with stainless steel for ILC 1.8 K cryomodule

    Science.gov (United States)

    Sabirov, B. M.; Budagov, J. A.; Shirkov, G. D.

    2013-07-01

    The world first samples of Ti and Nb tubes joint with stainless steel ones by an explosion welding by the JINR-VNIIEF-FNAL-INFN cooperation were manufactured in the frame of ILC R&D programe. An applying methods of relaxation of residual tensions (after explosion and electron beam welding), macro- and microanalyses of welding seam and cryogenic tests of the samples produced manifest the achievement of high mechanic strength (≈250 MPa/share) of welding seam, solidity and leak absence on 10-10 l atm/s level at 1.8 K. The explosion welding technology and methods introducing to industrial manufacturing of the 4-th generation of cryomodule of TESLA TYPE DESIGN can exclude the Ti—communications, connect the Nb—cavity with stainless steel vessel and reduce significantly the accelerator cost.

  5. Full simulation study of the top Yukawa coupling at the ILC at √(s) = 1 TeV

    Energy Technology Data Exchange (ETDEWEB)

    Price, T. [University of Birmingham, Birmingham (United Kingdom); Roloff, P. [CERN, Geneva (Switzerland); Strube, J. [Tohoku University, Sendai (Japan); Pacific Northwest National Laboratory, Richland, WA (United States); Tanabe, T. [ICEPP, The University of Tokyo, Tokyo (Japan)

    2015-07-15

    We present a study of the expected precision for the measurement of the top Yukawa coupling, y{sub t} in e{sup +}e{sup -} collisions at a center-of-mass energy of 1 TeV. Independent analyses of t anti tH final states containing at least six hadronic jets are performed, based on detailed simulations of SiD and ILD, the two candidate detector concepts for the ILC. We estimate that a statistical precision on y{sub t} of 4.5 % can be obtained with an integrated luminosity of 1 ab{sup -1} that is split equally between two configurations for the beam polarization P(e{sup -},e{sup +}), (-80 %, +20 %) and (+80 %, -20 %). This estimate improves to 4 % if the 1 ab{sup -1} sample is assumed to be fully in the P(e{sup -},e{sup +}) = (-80 %, +20 %) configuration. (orig.)

  6. Next Generation Fast RF Interlock Module and ATCA Adapter for ILC High Availability RF Test Station Demonstration

    Energy Technology Data Exchange (ETDEWEB)

    Larsen, R

    2009-10-17

    High availability interlocks and controls are required for the ILC (International Linear Collider) L-Band high power RF stations. A new F3 (Fast Fault Finder) VME module has been developed to process both fast and slow interlocks using FPGA logic to detect the interlock trip excursions. This combination eliminates the need for separate PLC (Programmable Logic Controller) control of slow interlocks. Modules are chained together to accommodate as many inputs as needed. In the next phase of development the F3's will be ported to the new industry standard ATCA (Advanced Telecom Computing Architecture) crate (shelf) via a specially designed VME adapter module with IPMI (Intelligent Platform Management Interface). The goal is to demonstrate auto-failover and hot-swap for future partially redundant systems.

  7. Development of a pixel sensor with fine space-time resolution based on SOI technology for the ILC vertex detector

    Science.gov (United States)

    Ono, Shun; Togawa, Manabu; Tsuji, Ryoji; Mori, Teppei; Yamada, Miho; Arai, Yasuo; Tsuboyama, Toru; Hanagaki, Kazunori

    2017-02-01

    We have been developing a new monolithic pixel sensor with silicon-on-insulator (SOI) technology for the International Linear Collider (ILC) vertex detector system. The SOI monolithic pixel detector is realized using standard CMOS circuits fabricated on a fully depleted sensor layer. The new SOI sensor SOFIST can store both the position and timing information of charged particles in each 20×20 μm2 pixel. The position resolution is further improved by the position weighted with the charges spread to multiple pixels. The pixel also records the hit timing with an embedded time-stamp circuit. The sensor chip has column-parallel analog-to-digital conversion (ADC) circuits and zero-suppression logic for high-speed data readout. We are designing and evaluating some prototype sensor chips for optimizing and minimizing the pixel circuit.

  8. Flavor-Changing Bottom-Strange Associated in the Littlest Higgs Model with T-parity at the ILC

    Institute of Scientific and Technical Information of China (English)

    李炳中; 韩金钟; 杨炳方

    2011-01-01

    In the littlest Higgs model with T-parity (LHT) the mirror quarks induce the special flavor structures and some new flavor-changing couplings, which could greatly enhance the production rates of the flavor-changing processes. We in this paper study some bottom and anti-strange production processes in the LHT model at the International Linear Collider (ILC), i.e., e+ e- -, bs and γγ-+ bs. The results show that the production rates of these processes are sizeable for the favorable values of the parameters. Therefore, it is quite possible to test the LHT model or make some constraints on the relevant parameters of the LHT through the detection of these processes at the ILC.

  9. Intrinsic Motivation in Physical Education

    Science.gov (United States)

    Davies, Benjamin; Nambiar, Nathan; Hemphill, Caroline; Devietti, Elizabeth; Massengale, Alexandra; McCredie, Patrick

    2015-01-01

    This article describes ways in which educators can use Harter's perceived competence motivation theory, the achievement goal theory, and self-determination theory to develop students' intrinsic motivation to maintain physical fitness, as demonstrated by the Sound Body Sound Mind curriculum and proven effective by the 2013 University of…

  10. Prediction of the light CP-even Higgs-boson mass of the MSSM. Towards the ILC precision

    Energy Technology Data Exchange (ETDEWEB)

    Hahn, T.; Hollik, W. [Max-Planck-Institut fuer Physik, Muenchen (Germany). Werner-Heisenberg-Institut; Heinemeyer, S. [Instituto de Fisica de Cantabria (CSIC-UC), Santander (Spain); Rzehak, H. [Freiburg Univ. (Germany). Physikalisches Inst.; Weiglein, G. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2014-04-15

    The signal discovered in the Higgs searches at the LHC can be interpreted as the Higgs boson of the Standard Model as well as the light CP-even Higgs boson of the Minimal Supersymmetric Standard Model (MSSM). In this context the measured mass value, having already reached the level of a precision observable with an experimental accuracy of about 500 MeV, plays an important role. This precision can be improved substantially below the level of ∝50 MeV at the future International Linear Collider (ILC). Within the MSSM the mass of the light CP-even Higgs boson, M{sub h}, can directly be predicted from the other parameters of the model. The accuracy of this prediction should match the one of the experimental measurements. The relatively high experimentally observed value of the mass of about 125.6 GeV has led to many investigations where the supersymmetric (SUSY) partners of the top quark have masses in the multi-TeV range. We review the recent improvements for the prediction for M{sub h} in the MSSM for large scalar top masses. They were obtained by combining the existing fixed-order result, comprising the full one-loop and leading and subleading two-loop corrections, with a resummation of the leading and subleading logarithmic contributions from the scalar top sector to all orders. In this way for the first time a high-precision prediction for the mass of the light CP-even Higgs boson in the MSSM is possible all the way up to the multi-TeV region of the relevant supersymmetric particles. However, substantial further improvements will be needed to reach the ILC precision. The newly obtained corrections to M{sub h} are included into the code FeynHiggs.

  11. Intrinsic Losses Based on Information Geometry and Their Applications

    Directory of Open Access Journals (Sweden)

    Yao Rong

    2017-08-01

    Full Text Available One main interest of information geometry is to study the properties of statistical models that do not depend on the coordinate systems or model parametrization; thus, it may serve as an analytic tool for intrinsic inference in statistics. In this paper, under the framework of Riemannian geometry and dual geometry, we revisit two commonly-used intrinsic losses which are respectively given by the squared Rao distance and the symmetrized Kullback–Leibler divergence (or Jeffreys divergence. For an exponential family endowed with the Fisher metric and α -connections, the two loss functions are uniformly described as the energy difference along an α -geodesic path, for some α ∈ { − 1 , 0 , 1 } . Subsequently, the two intrinsic losses are utilized to develop Bayesian analyses of covariance matrix estimation and range-spread target detection. We provide an intrinsically unbiased covariance estimator, which is verified to be asymptotically efficient in terms of the intrinsic mean square error. The decision rules deduced by the intrinsic Bayesian criterion provide a geometrical justification for the constant false alarm rate detector based on generalized likelihood ratio principle.

  12. Intrinsic square functions on the weighted Morrey spaces

    OpenAIRE

    Wang, Hua

    2011-01-01

    In this paper, we will study the boundedness properties of intrinsic square functions including the Lusin area integral, Littlewood-Paley $g$-function and $g^*_\\lambda$-function on the weighted Morrey spaces $L^{p,\\kappa}(w)$ for $1

  13. Harmonic structures and intrinsic torsion

    DEFF Research Database (Denmark)

    Conti, Diego; Madsen, Thomas Bruun

    We discuss the construction of 8-manifolds with harmonic Sp(2)Sp(1)-structures. In particular, we find 10 new examples of nilmanifolds that admit a closed 4-form Omega whose stabiliser is Sp(2)Sp(1). Our constructions entail the notion of SO(4)-structures on 7-manifolds. We present a thorough inv...... investigation of the intrinsic torsion of such structures; in addition to the construction of harmonic structures, this analysis leads to explicit Lie group examples with invariant intrinsic torsion.......We discuss the construction of 8-manifolds with harmonic Sp(2)Sp(1)-structures. In particular, we find 10 new examples of nilmanifolds that admit a closed 4-form Omega whose stabiliser is Sp(2)Sp(1). Our constructions entail the notion of SO(4)-structures on 7-manifolds. We present a thorough...

  14. Harmonic structures and intrinsic torsion

    DEFF Research Database (Denmark)

    Conti, Diego; Madsen, Thomas Bruun

    2015-01-01

    We discuss the construction of Sp(2)Sp(1)-structures whose fundamental form is closed. In particular, we find 10 new examples of 8-dimensional nilmanifolds that admit an invariant closed 4-form with stabiliser Sp(2) Sp(1). Our constructions entail the notion of SO(4)-structures on 7-manifolds. We...... present a thorough investigation of the intrinsic torsion of such structures, leading to the construction of explicit Lie group examples with invariant intrinsic torsion.......We discuss the construction of Sp(2)Sp(1)-structures whose fundamental form is closed. In particular, we find 10 new examples of 8-dimensional nilmanifolds that admit an invariant closed 4-form with stabiliser Sp(2) Sp(1). Our constructions entail the notion of SO(4)-structures on 7-manifolds. We...

  15. Intrinsic Patterns of Human Activity

    Science.gov (United States)

    Hu, Kun; Ivanov, Plamen Ch.; Chen, Zhi; Hilton, Michael; Stanley, H. Eugene; Shea, Steven

    2003-03-01

    Activity is one of the defining features of life. Control of human activity is complex, being influenced by many factors both extrinsic and intrinsic to the body. The most obvious extrinsic factors that affect activity are the daily schedule of planned events, such as work and recreation, as well as reactions to unforeseen or random events. These extrinsic factors may account for the apparently random fluctuations in human motion observed over short time scales. The most obvious intrinsic factors are the body clocks including the circadian pacemaker that influences our sleep/wake cycle and ultradian oscillators with shorter time scales [2, 3]. These intrinsic rhythms may account for the underlying regularity in average activity level over longer periods of up to 24 h. Here we ask if the known extrinsic and intrinsic factors fully account for all complex features observed in recordings of human activity. To this end, we measure activity over two weeks from forearm motion in subjects undergoing their regular daily routine. Utilizing concepts from statistical physics, we demonstrate that during wakefulness human activity possesses previously unrecognized complex dynamic patterns. These patterns of activity are characterized by robust fractal and nonlinear dynamics including a universal probability distribution and long-range power-law correlations that are stable over a wide range of time scales (from minutes to hours). Surprisingly, we find that these dynamic patterns are unaffected by changes in the average activity level that occur within individual subjects throughout the day and on different days of the week, and between subjects. Moreover, we find that these patterns persist when the same subjects undergo time-isolation laboratory experiments designed to account for the phase of the circadian pacemaker, and control the known extrinsic factors by restricting behaviors and manipulating scheduled events including the sleep/wake cycle. We attribute these newly

  16. Associated Production of a Photon with Dark Matter Pair at the ILC within the Littlest Higgs Model with T-parity

    Institute of Scientific and Technical Information of China (English)

    QIAO Qing-Peng; XU Bin

    2012-01-01

    Within the context of the Littlest Higgs model with T-parity, the heavy photon (AH) is supposed to be an ideM dark matter (DM) candidate. One direct proof of validity of the model is to produce the heavy photon at collider. In this paper, we investigate the associated production of a photon with heavy photon pair at the planned international e+ e- linear collider (ILC), i.e., e+e- → AHAHγ and show the distributions of the transverse momenta of the photon. The numerical results indicate that the heavy photon production rate could reach severaL fb at the low mass parameter space and the characteristic signal is a single high energetic photon and missing energy, carried by the heavy photons. All in a/l, it can be a good chance to observe the heavy photon via this process with the high yearly luminosity of the ILC.

  17. Full O(α electroweak radiative corrections to e+e−→e+e−γ at the ILC with GRACE-Loop

    Directory of Open Access Journals (Sweden)

    P.H. Khiem

    2015-01-01

    Full Text Available By using the GRACE-Loop system, we calculate the full O(α electroweak radiative corrections to the process e+e−→e+e−γ, which is important for future investigations at the International Linear Collider (ILC. With the GRACE-Loop system, the calculations are checked numerically by three consistency tests: ultraviolet finiteness, infrared finiteness, and gauge-parameter independence. The results show good numerical stability when quadruple precision is used. In the phenomenological results, we find that the electroweak corrections to the total cross section range from ∼−4% to ∼−21% when s varies from 250 GeV to 1 TeV. The corrections also significantly affect the differential cross sections, which are a function of energies and angles of the final state particles. Such corrections will play an important role in the high-precision program at the ILC.

  18. Intrinsic Defects and H Doping in WO3

    Science.gov (United States)

    Zhu, Jiajie; Vasilopoulou, Maria; Davazoglou, Dimitris; Kennou, Stella; Chroneos, Alexander; Schwingenschlögl, Udo

    2017-01-01

    WO3 is widely used as industrial catalyst. Intrinsic and/or extrinsic defects can tune the electronic properties and extend applications to gas sensors and optoelectonics. However, H doping is a challenge to WO3, the relevant mechanisms being hardly understood. In this context, we investigate intrinsic defects and H doping by density functional theory and experiments. Formation energies are calculated to determine the lowest energy defect states. O vacancies turn out to be stable in O-poor environment, in agreement with X-ray photoelectron spectroscopy, and O-H bond formation of H interstitial defects is predicted and confirmed by Fourier transform infrared spectroscopy. PMID:28098210

  19. Intrinsic Defects and H Doping in WO3

    KAUST Repository

    Zhu, Jiajie

    2017-01-18

    WO3 is widely used as industrial catalyst. Intrinsic and/or extrinsic defects can tune the electronic properties and extend applications to gas sensors and optoelectonics. However, H doping is a challenge to WO3, the relevant mechanisms being hardly understood. In this context, we investigate intrinsic defects and H doping by density functional theory and experiments. Formation energies are calculated to determine the lowest energy defect states. O vacancies turn out to be stable in O-poor environment, in agreement with X-ray photoelectron spectroscopy, and O-H bond formation of H interstitial defects is predicted and confirmed by Fourier transform infrared spectroscopy.

  20. Critical Points in Nuclei and Interacting Boson Model Intrinsic States

    CERN Document Server

    Ginocchio, J N; Ginocchio, Joseph N.

    2003-01-01

    We consider properties of critical points in the interacting boson model, corresponding to flat-bottomed potentials as encountered in a second-order phase transition between spherical and deformed $\\gamma$-unstable nuclei. We show that intrinsic states with an effective $\\beta$-deformation reproduce the dynamics of the underlying non-rigid shapes. The effective deformation can be determined from the the global minimum of the energy surface after projection onto the appropriate symmetry. States of fixed $N$ and good O(5) symmetry projected from these intrinsic states provide good analytic estimates to the exact eigenstates, energies and quadrupole transition rates at the critical point.

  1. Intrinsic Defects and H Doping in WO3

    Science.gov (United States)

    Zhu, Jiajie; Vasilopoulou, Maria; Davazoglou, Dimitris; Kennou, Stella; Chroneos, Alexander; Schwingenschlögl, Udo

    2017-01-01

    WO3 is widely used as industrial catalyst. Intrinsic and/or extrinsic defects can tune the electronic properties and extend applications to gas sensors and optoelectonics. However, H doping is a challenge to WO3, the relevant mechanisms being hardly understood. In this context, we investigate intrinsic defects and H doping by density functional theory and experiments. Formation energies are calculated to determine the lowest energy defect states. O vacancies turn out to be stable in O-poor environment, in agreement with X-ray photoelectron spectroscopy, and O-H bond formation of H interstitial defects is predicted and confirmed by Fourier transform infrared spectroscopy.

  2. Lattice Boltzmann modelling of intrinsic permeability

    CERN Document Server

    Li, Jun; Wu, Lei; Zhang, Yonghao

    2016-01-01

    Lattice Boltzmann method (LBM) has been applied to predict flow properties of porous media including intrinsic permeability, where it is implicitly assumed that the LBM is equivalent to the incompressible (or near incompressible) Navier-Stokes equation. However, in LBM simulations, high-order moments, which are completely neglected in the Navier-Stokes equation, are still available through particle distribution functions. To ensure that the LBM simulation is correctly working at the Navier-Stokes hydrodynamic level, the high-order moments have to be negligible. This requires that the Knudsen number (Kn) is small so that rarefaction effect can be ignored. In this technical note, we elaborate this issue in LBM modelling of porous media flows, which is particularly important for gas flows in ultra-tight media.

  3. Major Intrinsic Proteins in Biomimetic Membranes

    DEFF Research Database (Denmark)

    Helix Nielsen, Claus

    2010-01-01

    Biological membranes define the structural and functional boundaries in living cells and their organelles. The integrity of the cell depends on its ability to separate inside from outside and yet at the same time allow massive transport of matter in and out the cell. Nature has elegantly met...... this challenge by developing membranes in the form of lipid bilayers in which specialized transport proteins are incorporated. This raises the question: is it possible to mimic biological membranes and create a membrane based sensor and/or separation device? In the development of a biomimetic sensor....../separation technology, a unique class of membrane transport proteins is especially interesting the major intrinsic proteins (MIPs). Generally, MIPs conduct water molecules and selected solutes in and out of the cell while preventing the passage of other solutes, a property critical for the conservation of the cells...

  4. Full $\\mathcal{O}(\\alpha)$ electroweak radiative corrections to $t \\bar{t} \\gamma$ and $e^-e^+\\gamma$ productions at ILC with GRACE-Loop

    CERN Document Server

    Khiem, P H; Fujimoto, J; Igarashi, M; Ishikawa, T; Kaneko, T; Kato, K; Nakazawa, N; Shimizu, Y; Tobimatsu, K; Ueda, T; Vermaseren, J A M; Yasui, Y

    2013-01-01

    The full $\\mathcal{O}(\\alpha)$ electroweak radiative corrections to $t \\bar{t} \\gamma$ and $e^-e^+\\gamma$ productions at the International Linear Collider (ILC) are presented in this paper. The computation is performed with the help of GRACE-Loop system. In the physical results, we discuss on the cross section, electroweak corrections, and the top quark forward-backward asymmetry ($A_{FB}$) which are the function of the center-of-mass energy.

  5. Développement d'un capteur de pixels CMOS pour les couches externes du détecteur de vertex ILC

    OpenAIRE

    Zhang, Liang

    2013-01-01

    This work deals with the design of a CMOS pixel sensor prototype (called MIMOSA 31) for the outer layers of the International Linear Collider (ILC) vertex detector. CMOS pixel sensors (CPS) also called monolithic active pixel sensors (MAPS) have demonstrated attractive performance towards the requirements of the vertex detector of the future linear collider. MIMOSA 31developed at IPHC-Strasbourg is the first pixel sensor integrated with 4-bit column-level ADC for the outer layers. It is compo...

  6. Job assignments, intrinsic motivation and explicit incentives

    OpenAIRE

    Nafziger, Julia

    2008-01-01

    This paper considers the interplay of job assignments with the intrinsic and extrinsic motivation of an agent. Job assignments influence the self confidence of the agent, and thereby his intrinsic motivation. Monetary reward allow the principal to complement intrinsic motivation with extrinsic incentives. The main result is that the principal chooses an inefficient job assignment rule to enhance the agent's intrinsic motivation even though she can motivate him with monetary rewards. This show...

  7. Stochastic Intrinsic Kriging for Simulation Metamodelling

    NARCIS (Netherlands)

    Mehdad, E.; Kleijnen, Jack P.C.

    2014-01-01

    We derive intrinsic Kriging, using Matherons intrinsic random functions which eliminate the trend in classic Kriging. We formulate this intrinsic Kriging as a metamodel in deterministic and random simulation models. For random simulation we derive an experimental design that also specifies the numbe

  8. Discriminating Z' from anomalous trilinear gauge coupling signatures in e+e- \\to W+W- at ILC with polarized beams

    CERN Document Server

    Andreev, V V; Osland, P; Pankov, A A; Paver, N

    2012-01-01

    New heavy neutral gauge bosons Z' are predicted by many models of physics beyond the Standard Model. It is quite possible that Z's are heavy enough to lie beyond the discovery reach of the CERN Large Hadron Collider LHC, in which case only indirect signatures of Z' exchanges may emerge at future colliders, through deviations of the measured cross sections from the Standard Model predictions. We discuss in this context the foreseeable sensitivity to Z's of W^\\pm-pair production cross sections at the e^+e^- International Linear Collider (ILC), especially as regards the potential of distinguishing observable effects of the Z' from analogous ones due to competitor models with anomalous trilinear gauge couplings (AGC) that can lead to the same or similar new physics experimental signatures at the ILC. The sensitivity of the ILC for probing the Z-Z' mixing and its capability to distinguish these two new physics scenarios is substantially enhanced when the polarization of the initial beams and the produced W^\\pm bos...

  9. Scalar production in association with a Z boson at the LHC and ILC: The mixed Higgs-radion case of warped models

    Science.gov (United States)

    Angelescu, Andrei; Moreau, Grégory; Richard, François

    2017-07-01

    The radion scalar field might be the lightest new particle predicted by extradimensional extensions of the standard model. It could thus lead to the first signatures of new physics at the LHC collider. We perform a complete study of the radion production in association with the Z gauge boson in the custodially protected warped model with a brane-localized Higgs boson addressing the gauge hierarchy problem. Radion-Higgs mixing effects are present. Such a radion production receives possibly resonant contributions from the Kaluza-Klein excitations of the Z boson as well as the extra neutral gauge boson (Z'). All the exchange and mixing effects induced by those heavy bosons are taken into account in the radion coupling and rate calculations. The investigation of the considered radion production at the LHC allows us to be sensitive to some parts of the parameter space but only the ILC program at high luminosity would cover most of the theoretically allowed parameter space via the studied reaction. Complementary tests of the same theoretical parameters can be realized through the high accuracy measurements of the Higgs couplings at the ILC. The generic sensitivity limits on the rates discussed for the LHC and ILC potential reach can be applied to the searches for other (light) exotic scalar bosons.

  10. The Effects of Simplest Little Higgs Model on the Spin Correlations in the Top Quark Pair Production at the LHC and ILC

    Institute of Scientific and Technical Information of China (English)

    HAN Xiao-Fang; SHI Wen-Pu; WANG Lei

    2013-01-01

    In the simplest little Higgs model (SLH),we study the spin correlations in the top quark pair production at the LHC and ILC.We find that the SLH always suppresses the t(t-) spin correlations compared to the SM values.At the LHC,the suppression can be over 10% for mz,< 750 GeV.The SLH prediction value is outside the 1σ range of the experimental data from ATLAS,and within 1σ range of the experimental data from CMS.At the ILC,the SLH can sizably suppress the t(t-) spin correlation for mz' approaching the center-of-mass energy √s.For example,the maximal suppression can reach-22.5%,-14.5%,and-9.5% for √s =500 GeV,800 GeV,and 1000 GeV,respectively.Therefore,the t(t-) spin correlation at the ILC can be a sensitive probe for the SLH.

  11. SPIROC (SiPM Integrated Read-Out Chip) Dedicated very front-end electronics for an ILC prototype hadronic calorimeter with SiPM read-out

    CERN Document Server

    Bouchel, Michel; Fleury, Julien; de La Taille, Christophe; Martin-Chassard, Gisèle; Raux, Ludovic

    2007-01-01

    The SPIROC chip is a dedicated very front-end electronics for an ILC prototype hadronic calorimeter with Silicon photomultiplier (or MPPC) readout. This ASIC is due to equip a 10,000-channel demonstrator in 2009. SPIROC is an evolution of FLC_SiPM used for the ILC AHCAL physics prototype [1]. SPIROC was submitted in June 2007 and will be tested in September 2007. It embeds cutting edge features that fulfil ILC final detector requirements. It has been realized in 0.35m SiGe technology. It has been developed to match the requirements of large dynamic range, low noise, low consumption, high precision and large number of readout channels needed. SPIROC is an auto-triggered, bi-gain, 36-channel ASIC which allows to measure on each channel the charge from one photoelectron to 2000 and the time with a 100ps accurate TDC. An analogue memory array with a depth of 16 for each channel is used to store the time information and the charge measurement. A 12-bit Wilkinson ADC has been embedded to digitize the analogue memor...

  12. Qualification of the Second Batch Production 9-Cell Cavities Manufactured by AES and Validation of the First US Industrial Cavity Vendor for ILC

    Energy Technology Data Exchange (ETDEWEB)

    Geng, R. L. [Jefferson Lab., Newport News, VA (United States); Golden, B. A. [Jefferson Lab., Newport News, VA (United States); Kushnick, P. [Jefferson Lab., Newport News, VA (United States); Overton, R. B. [Jefferson Lab., Newport News, VA (United States); Calderaro, M. [AES, Medford, NY (United States); Peterson, E. [AES, Medford, NY (United States); Rathke, J. [AES, Medford, NY (United States); Champion, M. S. [FNAL, Batavia, IL (United States); Follkie, J. [FNAL, Batavia, IL (United States); Crawford, A. C. [FNAL, Batavia, IL (United States); Forehand, D. [Jefferson Lab., Newport News, VA (United States)

    2011-07-01

    One of the major goals of ILC SRF cavity R&D is to develop industrial capabilities of cavity manufacture and processing in all three regions. In the past several years, Jefferson Lab, in collaboration with Fermi National Accelerator Laboratory, has processed and tested all the 9-cell cavities of the first batch (4 cavities) and second batch (6 cavities) production cavities manufactured by Advanced Energy Systems Inc. (AES). Over the course, close information feedback was maintained, resulting in changes in fabrication and processing procedures. A light buffered chemical polishing was introduced, removing the weld splatters that could not be effectively removed by heavy EP alone. An 800 Celsius 2 hour vacuum furnace heat treatment procedure replaced the original 600 Celsius 10 hour procedure. Four out of the six 9-cell cavities of the second production bath achieved a gradient of 36-41 MV/m at a Q0 of more than 8E9 at 35 MV/m. This result validated AES as the first ''ILC certified'' industrial vendor in the US for ILC cavity manufacture.

  13. SPIROC (SiPM Integrated Read-Out Chip) Dedicated very front-end electronics for an ILC prototype hadronic calorimeter with SiPM read-out

    CERN Document Server

    Bouchel, Michel; Dulucq, Frédéric; Fleury, Julien; de La Taille, Christophe; Martin-Chassard, Gisèle; Raux, Ludovic

    2009-01-01

    The SPIROC chip is a dedicated very front-end electronics for an ILC prototype hadronic calorimeter with Silicon photomultiplier (or MPPC) readout. This ASIC is due to equip a 10,000-channel demonstrator in 2009. SPIROC is an evolution of FLC_SiPM used for the ILC AHCAL physics prototype [1]. SPIROC was submitted in June 2007 and will be tested in September 2007. It embeds cutting edge features that fulfil ILC final detector requirements. It has been realized in 0.35m SiGe technology. It has been developed to match the requirements of large dynamic range, low noise, low consumption, high precision and large number of readout channels needed. SPIROC is an auto-triggered, bi-gain, 36-channel ASIC which allows to measure on each channel the charge from one photoelectron to 2000 and the time with a 100ps accurate TDC. An analogue memory array with a depth of 16 for each channel is used to store the time information and the charge measurement. A 12-bit Wilkinson ADC has been embedded to digitize the analogue memor...

  14. Presymplectic structures and intrinsic Lagrangians

    CERN Document Server

    Grigoriev, Maxim

    2016-01-01

    It is well-known that a Lagrangian induces a compatible presymplectic form on the equation manifold (stationary surface, understood as a submanifold of the respective jet-space). Given an equation manifold and a compatible presymplectic form therein, we define the first-order Lagrangian system which is formulated in terms of the intrinsic geometry of the equation manifold. It has a structure of a presymplectic AKSZ sigma model for which the equation manifold, equipped with the presymplectic form and the horizontal differential, serves as the target space. For a wide class of systems (but not all) we show that if the presymplectic structure originates from a given Lagrangian, the proposed first-order Lagrangian is equivalent to the initial one and hence the Lagrangian per se can be entirely encoded in terms of the intrinsic geometry of its stationary surface. If the compatible presymplectic structure is generic, the proposed Lagrangian is only a partial one in the sense that its stationary surface contains the...

  15. Skiroc A Front-end Chip to Read Out the Imaging Silicon-Tungsten Calorimeter for ILC

    CERN Document Server

    Bouchel, Michel; Fleury, Julien; de La Taille, Christophe; Martin-Chassard,Gisèle; Raux, Ludovic; Wicek, Francois; Bohner, Gérard; Gay, Pascal; Lecoq, Jacques; Manen, Samuel; Royer, Laurent

    2007-01-01

    Integration and low-power consumption of the read-out ASIC for the International Linear Collider (ILC) 82-millionchannel W-Si calorimeter must reach an unprecedented level as it will be embedded inside the detector. Uniformity and dynamic range performance has to reach the accuracy to achieve calorimetric measurement. A first step towards this goal has been a 10,000-channel physics prototype of 18*18 cm which is currently in test beam in CERN. A new version of a full integrated read out chip (SKIROC) has been designed to equip the technologic prototype to be built for 2009. Based on the running physics prototype ASIC (FLC_PHY3), it embeds most of the required features expected for the final detector. The dynamic range has been improved from 500 to 2000 MIP. An auto-trigger capability has been added allowing built-in zero suppress. The number of channel has been doubled reaching 36 to fit smaller silicon pads and the lownoise charge preamplifier now accepts both AC and DC coupled detectors. After an exhaustive...

  16. Constraining parameter space of the little Higgs model using data from tera-Z factory and ILC

    Science.gov (United States)

    Guo, Xing-Dao; Feng, Tai-Fu; Zhao, Shu-Min; Ke, Hong-Wei; Li, Xue-Qian

    2015-02-01

    The Standard Model (SM) prediction on the forward-backward asymmetry for bb¯ production (AbFB)is well consistent with the data of LEP I at the Z-pole, but deviates from the data at √s = 89.55 and 92.95 GeV which are slightly away from the pole. This deviation implies that there is still room for new physics. We calculate the AbFB at the vicinity of the Z-pole in the little Higgs model as well as other measurable parameters such as Rb and Rc, by which we may constrain the parameter space of the little Higgs model. This can be further tested in the newly proposed tera-Z factory. With the fitted parameters we further make predictions on AbFB and AtFB for tt¯ production at the International Linear Collider (ILC). Supported by National Natural Science Foundation of China (11275036, 11047002, 11375128), Fund of Natural Science Foundation of Hebei Province(A2011201118) and Natural Science Fund of Hebei University (2011JQ05, 2007113)

  17. Intrinsic Motivation Predicting Performance Satisfaction in Athletes: Further Psychometric Evaluations of the Sport Motivation Scale-6

    National Research Council Canada - National Science Library

    Jan Blecharz; Karolina Horodyska; Karolina Zarychta; Aleksandra Adamiec; Aleksandra Luszczynska

    2015-01-01

    The study investigated psychometric properties of the Sport Motivation Scale-6 (SMS-6), assessing intrinsic regulation, four extrinsic regulation constructs, and amotivation among athletes competing at a regional and national level...

  18. The boundedness of intrinsic square functions on the weighted Herz-type Hardy spaces

    CERN Document Server

    Wang, Hua

    2010-01-01

    In this paper, the boundedness properties are obtained for intrinsic square functions including the Lusin area function, Littlewood-Paley $g$-function and $g^*_\\lambda$-function on the weighted Herz-type Hardy spaces.

  19. First principles studies of extrinsic and intrinsic defects in boron nitride nanotubes

    CSIR Research Space (South Africa)

    Mashapa, MG

    2012-10-01

    Full Text Available Spin polarized density functional theory has been used to investigate the structural stability and electronic properties of extrinsic and intrinsic defects in boron nitride nanotubes. Carbon substitutional defects under nitrogen rich and boron...

  20. Production of Doubly Charmed Baryons at the SELEX: double intrinsic charm approach

    CERN Document Server

    Koshkarev, Sergey

    2016-01-01

    In this paper we study the role of the double intrinsic charm mechanism in the production of the doubly charmed baryons at the SELEX experiment. The predictions of the cross section and related production properties are presented.

  1. Intrinsic ferroelectric switching from first principles

    Science.gov (United States)

    Liu, Shi; Grinberg, Ilya; Rappe, Andrew M.

    2016-06-01

    The existence of domain walls, which separate regions of different polarization, can influence the dielectric, piezoelectric, pyroelectric and electronic properties of ferroelectric materials. In particular, domain-wall motion is crucial for polarization switching, which is characterized by the hysteresis loop that is a signature feature of ferroelectric materials. Experimentally, the observed dynamics of polarization switching and domain-wall motion are usually explained as the behaviour of an elastic interface pinned by a random potential that is generated by defects, which appear to be strongly sample-dependent and affected by various elastic, microstructural and other extrinsic effects. Theoretically, connecting the zero-kelvin, first-principles-based, microscopic quantities of a sample with finite-temperature, macroscopic properties such as the coercive field is critical for material design and device performance; and the lack of such a connection has prevented the use of techniques based on ab initio calculations for high-throughput computational materials discovery. Here we use molecular dynamics simulations of 90° domain walls (separating domains with orthogonal polarization directions) in the ferroelectric material PbTiO3 to provide microscopic insights that enable the construction of a simple, universal, nucleation-and-growth-based analytical model that quantifies the dynamics of many types of domain walls in various ferroelectrics. We then predict the temperature and frequency dependence of hysteresis loops and coercive fields at finite temperatures from first principles. We find that, even in the absence of defects, the intrinsic temperature and field dependence of the domain-wall velocity can be described with a nonlinear creep-like region and a depinning-like region. Our model enables quantitative estimation of coercive fields, which agree well with experimental results for ceramics and thin films. This agreement between model and experiment suggests

  2. Intrinsic optimization using stochastic nanomagnets

    Science.gov (United States)

    Sutton, Brian; Camsari, Kerem Yunus; Behin-Aein, Behtash; Datta, Supriyo

    2017-01-01

    This paper draws attention to a hardware system which can be engineered so that its intrinsic physics is described by the generalized Ising model and can encode the solution to many important NP-hard problems as its ground state. The basic constituents are stochastic nanomagnets which switch randomly between the ±1 Ising states and can be monitored continuously with standard electronics. Their mutual interactions can be short or long range, and their strengths can be reconfigured as needed to solve specific problems and to anneal the system at room temperature. The natural laws of statistical mechanics guide the network of stochastic nanomagnets at GHz speeds through the collective states with an emphasis on the low energy states that represent optimal solutions. As proof-of-concept, we present simulation results for standard NP-complete examples including a 16-city traveling salesman problem using experimentally benchmarked models for spin-transfer torque driven stochastic nanomagnets. PMID:28295053

  3. Intrinsic plasmarons in warm graphene

    Science.gov (United States)

    Liu, Daqing; Chen, Shuyue; Zhang, Shengli; Ma, Ning

    2017-10-01

    Based on a self-consistent method, we predict theoretically that there exist intrinsic plasmarons in graphene at nonzero temperature, with a well defined mode, as shown by the result of Landau damping. We find that there are sharp differences between the discussed system and the QCD/QED system. Firstly, the thermal mass is proportional to α_g3/4T but not αg T . Secondly, at 0c , the fermion channel and plasmaron channel are nearly degenerate, and furthermore the energy difference between fermion and plasmaron becomes larger and larger with increasing q in the region q>qc . Thirdly, the fermion behaves as a ‘relativistic particle’ with nonzero mass, and the plasmaron exhibits an abnormal dispersion at moderate momentum.

  4. Intrinsic Instability of Coronal Streamers

    CERN Document Server

    Chen, Y; Song, H Q; Shi, Q Q; Feng, S W; Xia, L D; 10.1088/0004-637X/691/2/1936

    2009-01-01

    Plasma blobs are observed to be weak density enhancements as radially stretched structures emerging from the cusps of quiescent coronal streamers. In this paper, it is suggested that the formation of blobs is a consequence of an intrinsic instability of coronal streamers occurring at a very localized region around the cusp. The evolutionary process of the instability, as revealed in our calculations, can be described as follows: (1) through the localized cusp region where the field is too weak to sustain the confinement, plasmas expand and stretch the closed field lines radially outward as a result of the freezing-in effect of plasma-magnetic field coupling; the expansion brings a strong velocity gradient into the slow wind regime providing the free energy necessary for the onset of a subsequent magnetohydrodynamic instability; (2) the instability manifests itself mainly as mixed streaming sausage-kink modes, the former results in pinches of elongated magnetic loops to provoke reconnections at one or many loc...

  5. Intrinsic gain modulation and adaptive neural coding.

    Directory of Open Access Journals (Sweden)

    Sungho Hong

    Full Text Available In many cases, the computation of a neural system can be reduced to a receptive field, or a set of linear filters, and a thresholding function, or gain curve, which determines the firing probability; this is known as a linear/nonlinear model. In some forms of sensory adaptation, these linear filters and gain curve adjust very rapidly to changes in the variance of a randomly varying driving input. An apparently similar but previously unrelated issue is the observation of gain control by background noise in cortical neurons: the slope of the firing rate versus current (f-I curve changes with the variance of background random input. Here, we show a direct correspondence between these two observations by relating variance-dependent changes in the gain of f-I curves to characteristics of the changing empirical linear/nonlinear model obtained by sampling. In the case that the underlying system is fixed, we derive relationships relating the change of the gain with respect to both mean and variance with the receptive fields derived from reverse correlation on a white noise stimulus. Using two conductance-based model neurons that display distinct gain modulation properties through a simple change in parameters, we show that coding properties of both these models quantitatively satisfy the predicted relationships. Our results describe how both variance-dependent gain modulation and adaptive neural computation result from intrinsic nonlinearity.

  6. Partial Coverage and Time Variability of Narrow-Line Intrinsic QSO Absorption Systems

    CERN Document Server

    Barlow, T A; Sargent, W L W; Barlow, Thomas A.

    1997-01-01

    It is possible to distinguish ``intrinsic'' absorption systems (gas clouds within the quasar environment) from ``intervening'' systems (gas clouds unrelated to the quasar phenomenon) by considering certain observational properties. We find that the most direct determinations of the intrinsic nature of a system are time variability and partial coverage of the background light source by the absorption region. Both of these conditions are unlikely to occur in intervening systems. We present Keck and HIRES data which demonstrate both these phenomena. We also summarize a list of several other observational properties which appear to be indicative of ``intrinsic'' systems.

  7. Design of intrinsically safe power supply

    Institute of Scientific and Technical Information of China (English)

    LI Rui-jin; JIN Lin

    2012-01-01

    Aiming to make a high power direct current supply safely used in coal mine production,this paper made a deep research on characteristics of intrinsically safe power supply,using the mathematical model established according to coal mine intrinsic safety standards.It provides theory support for the application of high power intrinsically safe power supply.The released energy of output short circuit of switch power supply,and the close related factors that influence the biggest output short-circuit spark discharge energy are the theoretical basis of the power supply.It is shown how to make a high power intrinsically safe power supply using the calculated values in the mathematical model,and take values from intrinsically safe requirements parameters scope,then this theoretical calculation value can be developed as the ultimate basis for research of the power supply.It gets the identification method of intrinsically safe from mathematics model of intrinsically safe power supply characteristics study,which solves the problem of theory and application of designing different power intrinsically safe power supply,and designs a kind of high power intrinsically safe power supply through this method.

  8. Algebraic description of intrinsic modes in nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Leviatan, A. (Los Alamos National Lab., NM (USA))

    1990-01-01

    We present a procedure for extracting normal modes in algebraic number-conserving systems of interacting bosons relevant for collective states in even-even nuclei. The Hamiltonian is resolved into intrinsic (bandhead related) and collective (in-band related) parts. Shape parameters are introduced through non-spherical boson bases. Intrinsic modes decoupled from the spurious modes are obtained from the intrinsic part of the Hamiltonian in the limit of large number of bosons. Intrinsic states are constructed and serve to evaluate electromagnetic transition rates. The method is illustrated for systems with one type of boson as well as with proton-neutron bosons. (author).

  9. Incentives and intrinsic motivation in healthcare

    Directory of Open Access Journals (Sweden)

    Mikel Berdud

    2016-11-01

    Conclusions: The conclusions could act as a guide to support the optimal design of incentive policies and schemes within health organisations when healthcare professionals are intrinsically motivated.

  10. Intrinsically photosensitive retinal ganglion cells

    Institute of Scientific and Technical Information of China (English)

    Gary; E.PICKARD; Patricia; J.SOLLARS

    2010-01-01

    A new mammalian photoreceptor was recently discovered to reside in the ganglion cell layer of the inner retina.These intrinsically photosensitive retinal ganglion cells(ipRGCs) express a photopigment,melanopsin,that confers upon them the ability to respond to light in the absence of all rod and cone photoreceptor input.Although relatively few in number,ipRGCs extend their dendrites across large expanses of the retina making them ideally suited to function as irradiance detectors to assess changes in ambient light levels.Phototransduction in ipRGCs appears to be mediated by transient receptor potential channels more closely resembling the phototransduction cascade of invertebrate rather than vertebrate photoreceptors.ipRGCs convey irradiance information centrally via the optic nerve to influence several functions.ipRGCs are the primary retinal input to the hypothalamic suprachiasmatic nucleus(SCN),a circadian oscillator and biological clock,and this input entrains the SCN to the day/night cycle.ipRGCs contribute irradiance signals that regulate pupil size and they also provide signals that interface with the autonomic nervous system to regulate rhythmic gene activity in major organs of the body.ipRGCs also provide excitatory drive to dopaminergic amacrine cells in the retina,providing a novel basis for the restructuring of retinal circuits by light.Here we review the ground-breaking discoveries,current progress and directions for future investigation.

  11. SPIROC (SiPM Integrated Read-Out Chip): dedicated very front-end electronics for an ILC prototype hadronic calorimeter with SiPM read-out

    Science.gov (United States)

    Bouchel, M.; Callier, S.; Dulucq, F.; Fleury, J.; Jaeger, J.-J.; de La Taille, C.; Martin-Chassard, G.; Raux, L.

    2011-01-01

    The SPIROC chip is a dedicated very front-end electronics for an ILC (International Linear Collider) prototype of hadronic calorimeter using Silicon photomultiplier (SiPM) or Multi-Pixel Photon Counters (MPPC) readout. This ASIC is due to equip a 10,000-channel demonstrator in 2010. SPIROC is an evolution of FLC-SiPM used for the ILC Analogue HCAL physics prototype. The first prototype of SPIROC was submitted in June 2007. It embeds cutting edge features that fulfil ILC final detector requirements. It has been realized in 0.35 μm SiGe technology. It has been developed to match the requirements of large dynamic range, low noise, low consumption, high precision and large number of readout channels needed. SPIROC is an auto-triggered, dual gain, 36-channel ASIC which allows to measure on each channel the charge from one photoelectron to 2,000 photoelectron and the time with a 100 ps accurate Time-to-digital Converter (TDC). An analogue memory array with a depth of 16 for each channel is used to store the time information and the charge measurement. A 12-bit Wilkinson Analogue-to-digital Converter (ADC) has been embedded to digitize the analogue memory content (time and charge on 2 gains). The data are then stored in a 4 Kbytes RAM. A very complex digital part has been integrated to manage all these features and to transfer the data to the DAQ which is described in Dulucq et al. After an exhaustive description, the extensive measurement results of this new front-end chip are presented.

  12. Ideas on DC-DC Converters for Delivery of Low Voltage and High Currents for the SLHC / ILC Detector Electronics in Magnetic field and Radiation environments

    CERN Document Server

    Dhawan, Satish; Neal, H; Sumner, R; Weber, M; Weber, R

    2007-01-01

    For more efficient power transport to the electronics embedded inside large colliding beam detectors, we explore the feasibility of supplying 48 Volts DC and using local DCDC conversion to 2 V (or lower, depending upon on the lithography of the embedded electronics) using switch mode regulators located very close to the front end electronics. These devices will be exposed to high radiation and high magnetic fields, 10 – 100 Mrads and 2 - 4 Tesla at the SLHC, and 20 Krads and 6 Tesla at the ILC.

  13. Rotational Crofton formulae for flagged intrinsic volumes

    DEFF Research Database (Denmark)

    Auneau, Jeremy Michel

    , and the integration is over all sections containing the fixed point origo. Our main result is a local stereological analogue to the well-known Crofton formula. More precisely, we derive geometric formulae that relate new flagged intrinsic volumes of a set with the flagged intrinsic volumes of its sections...

  14. Intrinsic bioremediation of landfills interim report

    Energy Technology Data Exchange (ETDEWEB)

    Brigmon, R.L. [Westinghouse Savannah River Company, Aiken, SC (United States); Fliermans, C.B.

    1997-07-14

    Intrinsic bioremediation is a risk management option that relies on natural biological and physical processes to contain the spread of contamination from a source. Evidence is presented in this report that intrinsic bioremediation is occurring at the Sanitary Landfill is fundamental to support incorportion into a Corrective Action Plan (CAP).

  15. On Intrinsic Magnetic Moments In Black Hole Candidates

    CERN Document Server

    Robertson, S L; Robertson, Stanley L.; Leiter, Darryl J.

    2003-01-01

    In previous work we found that many of the spectral properties of low mass x-ray binaries, including galactic black hole candidates could be explained by a magnetic propeller model that requires an intrinsically magnetized central object. Here we describe how the Einstein field equations of General Relativity and equipartition magnetic fields permit the existence of highly red shifted, extremely long lived, collapsing, radiating objects. We examine the properties of these collapsed objects and discuss characteristics that might lead to their confirmation as the source of black hole candidate phenomena.

  16. Intrinsic valley Hall effect in graphene

    Science.gov (United States)

    Yang, Mou; Zhang, Wen-Lian; Liu, Hai; Bai, Yan-Kui

    2017-04-01

    If electrons are incident from an armchair graphene ribbon into the bulk graphene region, the electronic diffraction occurs. Because of the different triangular wrapping of the energy dispersion between valleys K and K ‧ , the electrons of valley K tend to be diffracted to one side and those of valley K ‧ to the other side. When the current is injected from the armchair ribbon of a four-terminal graphene device, the major portion of the incident current of valley K flows through one side arm and the minor portion through the other side arm. The ratio between them is derived to be 1 + 4 E / 3 in the low energy limit, where E is the energy in units of hopping parameter. The major arm for valley K is the minor arm for valley K ‧ . This results in the rise of the valley Hall effect, which is an intrinsic property of graphene stemming from the different electronic structure of the two valleys. The valley Hall conductance is calculated to be (2 E / 3)G0 with G0 being the conductance supported by the injection ribbon.

  17. Intrinsically disordered proteins: structural and functional dynamics

    Directory of Open Access Journals (Sweden)

    Wallin S

    2017-02-01

    Full Text Available Stefan Wallin Department of Physics and Physical Oceanography, Memorial University of Newfoundland, St. John’s, NL, Canada Abstract: The classical view holds that proteins fold into essentially unique three-dimensional structures before becoming biologically active. However, studies over the last several years have provided broad and convincing evidence that some proteins do not adopt a single structure and yet are fully functional. These intrinsically disordered proteins (IDPs have been found to be highly prevalent in many genomes, including human, and play key roles in central cellular processes, such as regulation of transcription and translation, cell cycle, and cell signaling. Moreover, IDPs are overrepresented among proteins implicated in disease, including various cancers and neurodegenerative disorders. Intense efforts, by using both experimental and computational approaches, are consequently under way to uncover the molecular mechanisms that underpin the roles of IDPs in biology and disease. This review provides an introduction to the general biophysical properties of IDPs and discusses some of the recent emerging areas in IDP research, including the roles of IDPs in allosteric regulation, regulatory unfolding, and formation of intracellular membrane-less organelles. In addition, recent attempts at therapeutic targeting of IDPs by small molecules, noting in particular that IDPs represent a potentially important source of new drug targets in light of their central role in protein–protein interaction networks, are also reviewed. Keywords: natively unfolded proteins, unstructured proteins, protein folding, protein–protein interaction, cell regulation, signaling, drug development, inhibitors

  18. Stretching instability of intrinsically curved semiflexible biopolymers:A lattice model approach

    Institute of Scientific and Technical Information of China (English)

    周子聪; 林方庭; 陈柏翰

    2015-01-01

    We apply Monte Carlo simulation method to lattice systems to study the effect of an intrinsic curvature on the me-chanical property of a semifl exible biopolymer. We find that when the intrinsic curvature is sufficient large, the extension of a semifl exible biopolymer can undergo a first-order transition at finite temperature. The critical force increases with in-creasing intrinsic curvature. But the relationship between the critical force and the bending rigidity is structure-dependent. In triangle lattice system, when the intrinsic curvature is smaller than a critical value, the critical force increases with the increasing bending rigidity first, and then decreases with the increasing bending rigidity. But in square lattice system, the critical force always decreases with the increasing bending rigidity. In contrast, when the intrinsic curvature is greater than the critical value, the larger bending rigidity always results in a larger critical force in both lattice systems.

  19. Intrinsic Evaporative Cooling by Hygroscopic Earth Materials

    Directory of Open Access Journals (Sweden)

    Alexandra R. Rempel

    2016-08-01

    Full Text Available The phase change of water from liquid to vapor is one of the most energy-intensive physical processes in nature, giving it immense potential for cooling. Diverse evaporative cooling strategies have resulted worldwide, including roof ponds and sprinklers, courtyard fountains, wind catchers with qanats, irrigated green roofs, and fan-assisted evaporative coolers. These methods all require water in bulk liquid form. The evaporation of moisture that has been sorbed from the atmosphere by hygroscopic materials is equally energy-intensive, however, yet has not been examined for its cooling potential. In arid and semi-arid climates, hygroscopic earth buildings occur widely and are known to maintain comfortable indoor temperatures, but evaporation of moisture from their walls and roofs has been regarded as unimportant since water scarcity limits irrigation and rainfall; instead, their cool interiors are attributed to well-established mass effects in delaying the transmission of sensible gains. Here, we investigate the cooling accomplished by daily cycles of moisture sorption and evaporation which, requiring only ambient humidity, we designate as “intrinsic” evaporative cooling. Connecting recent soil science to heat and moisture transport studies in building materials, we use soils, adobe, cob, unfired earth bricks, rammed earth, and limestone to reveal the effects of numerous parameters (temperature and relative humidity, material orientation, thickness, moisture retention properties, vapor diffusion resistance, and liquid transport properties on the magnitude of intrinsic evaporative cooling and the stabilization of indoor relative humidity. We further synthesize these effects into concrete design guidance. Together, these results show that earth buildings in diverse climates have significant potential to cool themselves evaporatively through sorption of moisture from humid night air and evaporation during the following day’s heat. This finding

  20. Long-term potentiation of intrinsic excitability in trigeminal motoneurons.

    Science.gov (United States)

    Okamoto, Reiko; Enomoto, Akifumi; Koizumi, Hidehiko; Tanaka, Susumu; Ishihama, Kohji; Kogo, Mikihiko

    2010-02-02

    Trigeminal motoneurons (TMNs) relay the final output signals generated within the oral-motor pattern-generating circuits to the jaw muscles for execution of various patterns of motor activity. Activity-dependent plasticity, referred to as long-term potentiation (LTP), in the central nervous system has been the subject of many studies. The mechanisms of plasticity in the trigeminal system, an important component of the oral-motor system underlying mastication, swallowing, and other behaviors, remain to be fully elucidated. In the present study, we investigated long-term potentiation of intrinsic excitability (LTP-IE) in TMNs. Experiments were performed using extracellular recording and whole-cell patch-clamp recording to assess the intrinsic excitability of TMNs. Intrinsic response properties were examined using an induction pulse with ionotropic transmission blocked. The output of the trigeminal motor branch exhibited long-lasting potentiation of intrinsic neuronal excitability following induction. Applying brainstem transection techniques to the neonatal rat brainstem in vitro, we found that the activity of the motoneuron population recorded from the motor branch of the trigeminal nerve exhibited LTP-IE. We thus demonstrated the usefulness of this type of preparation for the study of rudimentary oral-motor activity and observed changes in TMN excitability. In addition, on testing with the whole-cell patch-clamp method, TMNs exhibited a significant increase in excitability with a leftward shift in F-I curves generated with depolarizing current injections, whereas resting membrane potential and input resistance exhibited no remarkable changes. These findings indicate that TMNs exhibit LTP of intrinsic excitability.

  1. Mutant p53 accumulation in human breast cancer is not an intrinsic property or dependent on structural or functional disruption but is regulated by exogenous stress and receptor status.

    Science.gov (United States)

    Bouchalova, Pavla; Nenutil, Rudolf; Muller, Petr; Hrstka, Roman; Appleyard, M Virginia; Murray, Karen; Jordan, Lee B; Purdie, Colin A; Quinlan, Philip; Thompson, Alastair M; Vojtesek, Borivoj; Coates, Philip J

    2014-07-01

    Many human cancers contain missense TP53 mutations that result in p53 protein accumulation. Although generally considered as a single class of mutations that abrogate wild-type function, individual TP53 mutations may have specific properties and prognostic effects. Tumours that contain missense TP53 mutations show variable p53 stabilization patterns, which may reflect the specific mutation and/or aspects of tumour biology. We used immunohistochemistry on cell lines and human breast cancers with known TP53 missense mutations and assessed the effects of each mutation with four structure-function prediction methods. Cell lines with missense TP53 mutations show variable percentages of cells with p53 stabilization under normal growth conditions, ranging from approximately 50% to almost 100%. Stabilization is not related to structural or functional disruption, but agents that stabilize wild-type p53 increase the percentages of cells showing missense mutant p53 accumulation in cell lines with heterogeneous stabilization. The same heterogeneity of p53 stabilization occurs in primary breast cancers, independent of the effect of the mutation on structural properties or functional disruption. Heterogeneous accumulation is more common in steroid receptor-positive or HER2-positive breast cancers and cell lines than in triple-negative samples. Immunohistochemcal staining patterns associate with Mdm2 levels, proliferation, grade and overall survival, whilst the type of mutation reflects downstream target activity. Inhibiting Mdm2 activity increases the extent of p53 stabilization in some, but not all, breast cancer cell lines. The data indicate that missense mutant p53 stabilization is a complex and variable process in human breast cancers that associates with disease characteristics but is unrelated to structural or functional properties. That agents which stabilize wild-type p53 also stabilize mutant p53 has implications for patients with heterogeneous mutant p53 accumulation

  2. Correlation between intrinsic dipole moment and pyroelectric coefficient of Fe-Mg tourmaline

    Institute of Scientific and Technical Information of China (English)

    Chang-chun Zhao; Li-bing Liao; Jie Xing

    2014-01-01

    Single-crystal X-ray diffraction structural data of four Fe-Mg tourmalines with different Fe contents from Xinjiang, Sichuan, and Yunnan Provinces, China, were collected at room temperature and-100ºC. The intrinsic dipole moments of polyhedra and the total intrinsic dipole moment of the unit cell were calculated. By comparing the intrinsic electric dipole moments of the X, Y, Z, T, and B site polyhedra, it is found that the T site polyhedron makes the greatest contribution to the total intrinsic dipole moment. The pyroelectric coefficients of four Fe-Mg tourmalines were experimentally determined, and the influence of intrinsic dipole moments on their pyroelectric properties was inves-tigated. The experimental results show that, compared with the case at room temperature, the intrinsic dipole moments change with the total Fe content at-100ºC in a completely different way. With the decrease of temperature, the total intrinsic dipole moments of tourmaline de-crease. Over the same temperature interval, the pyroelectric coefficients increase with the increase in intrinsic dipole moment.

  3. Intrinsic structure in Saturn's rings

    Science.gov (United States)

    Albers, N.

    2015-10-01

    Saturn's rings are the most prominent in our Solar system and one example of granular matter in space. Dominated by tides and inelastic collisions the system is highly flattened being almost 300000km wide while only tens of meters thick. Individual particles are composed of primarily water ice and range from microns to few tens of meters in size. Apparent patterns comprise ringlets, gaps, kinematic wakes, propellers, bending waves, and the winding spiral arms of density waves. These large-scale structures are perturbations foremost created by external as well as embedded moons. Observations made by the Cassini spacecraft currently in orbit around Saturn show these structures in unprecedented detail. But high-resolution measurements reveal the presence of small-scale structures throughout the system. These include self-gravity wakes (50-100m), overstable waves (100-300m), subkm structure at the A and B ring edges, "straw" and "ropy" structures (1-3km), and the C ring "ghosts". Most of these had not been anticipated and are found in perturbed regions, driven by resonances with external moons, where the system undergoes periodic phases of compression and relaxation that correlate with the presence of structure. High velocity dispersion and the presence of large clumps imply structure formation on time scales as short as one orbit (about 10 hours). The presence of these intrinsic structures is seemingly the response to varying local conditions such as internal density, optical depth, underlying particle size distribution, granular temperature, and distance from the central planet. Their abundance provides evidence for an active and dynamic ring system where aggregation and fragmentation are ongoing on orbital timescales. Thus a kinetic description of the rings may be more appropriate than the fluid one. I will present Cassini Ultraviolet Spectrometer (UVIS) High Speed Photometer (HSP) occultations, Voyager 1 and 2 Imaging Science Subsystem (ISS), and high

  4. Intrinsic oscillations of neocortex generated by layer 5 pyramidal neurons.

    Science.gov (United States)

    Silva, L R; Amitai, Y; Connors, B W

    1991-01-25

    Rhythmic activity in the neocortex varies with different behavioral and pathological states and in some cases may encode sensory information. However, the neural mechanisms of these oscillations are largely unknown. Many pyramidal neurons in layer 5 of the neocortex showed prolonged, 5- to 12-hertz rhythmic firing patterns at threshold. Rhythmic firing was due to intrinsic membrane properties, sodium conductances were essential for rhythmicity, and calcium-dependent conductances strongly modified rhythmicity. Isolated slices of neocortex generated epochs of 4- to 10-hertz synchronized activity when N-methyl-D-aspartate receptor-mediated channels were facilitated. Layer 5 was both necessary and sufficient to produce these synchronized oscillations. Thus, synaptic networks of intrinsically rhythmic neurons in layer 5 may generate or promote certain synchronized oscillations of the neocortex.

  5. Intrinsic Oscillations of Neocortex Generated by Layer 5 Pyramidal Neurons

    Science.gov (United States)

    Silva, Laurie R.; Amitai, Yael; Connors, Barry W.

    1991-01-01

    Rhythmic activity in the neocortex varies with different behavioral and pathological states and in some cases may encode sensory information. However, the neural mechanisms of these oscillations are largely unknown. Many pyramidal neurons in layer 5 of the neocortex showed prolonged, 5- to 12-hertz rhythmic firing patterns at threshold. Rhythmic firing was due to intrinsic membrane properties, sodium conductances were essential for rhythmicity, and calcium-dependent conductances strongly modified rhythmicity. Isolated slices of neocortex generated epochs of 4- to 10-hertz synchronized activity when N-methyl-D-aspartate receptor-mediated channels were facilitated. Layer 5 was both necessary and sufficient to produce these synchronized oscillations. Thus, synaptic networks of intrinsically rhythmic neurons in layer 5 may generate or promote certain synchronized oscillations of the neocortex.

  6. T helper 2 (Th2) cell differentiation, type 2 innate lymphoid cell (ILC2) development and regulation of interleukin-4 (IL-4) and IL-13 production.

    Science.gov (United States)

    Zhu, Jinfang

    2015-09-01

    Interleukin-4 (IL-4), IL-5 and IL-13, the signature cytokines that are produced during type 2 immune responses, are critical for protective immunity against infections of extracellular parasites and are responsible for asthma and many other allergic inflammatory diseases. Although many immune cell types within the myeloid lineage compartment including basophils, eosinophils and mast cells are capable of producing at least one of these cytokines, the production of these "type 2 immune response-related" cytokines by lymphoid lineages, CD4 T helper 2 (Th2) cells and type 2 innate lymphoid cells (ILC2s) in particular, are the central events during type 2 immune responses. In this review, I will focus on the signaling pathways and key molecules that determine the differentiation of naïve CD4 T cells into Th2 cells, and how the expression of Th2 cytokines, especially IL-4 and IL-13, is regulated in Th2 cells. The similarities and differences in the differentiation of Th2 cells, IL-4-producing T follicular helper (Tfh) cells and ILC2s as well as their relationships will also be discussed.

  7. IL-17 producing innate lymphoid cells 3 (ILC3) but not Th17 cells might be the potential danger factor for preeclampsia and other pregnancy associated diseases.

    Science.gov (United States)

    Barnie, Prince A; Lin, Xin; Liu, Yueqin; Xu, Huaxi; Su, Zhaoliang

    2015-01-01

    In pregnancy, the immunologic system plays an important role that ensures normal pregnancy development and can as well promote the development of complications. Pregnancy success appears to rely on a discrete balance between the Th cytokines, which are involved in fetal growth and development. Preeclampsia and gestational diabetes are known complications associated with pregnancy. However, the source of the increased IL-17 cytokine in preeclampsia and other pregnancy associated diseases still remains unclear amidst numerous inconsistencies. The recent identification of innate lymphoid cells (ILC) has raised more doubts about the sources of most of the Th associated cytokines. We investigated the source of peripheral IL-17 levels in preeclamptic, gestational diabetics and chronic diabetics compared to healthy pregnancy subjects. To evaluate the source of the increased IL-17 cytokine among preeclampsia, chronic diabetic and gestational diabetic patients we investigated the proportion of Th17 cell populations in peripheral blood mononuclear cells using flow cytometry as well as analyzing levels of IFN-γ, IL-17, IL-1β and HMGB1. This study found that the Th17 cell populations in peripheral blood of preeclamptic, gestational nor chronic diabetes during pregnancy did not correlate with the increased IL-17. We report that the increased IL-17 levels observed in patients with preeclampsia, gestational diabetes and chronic diabetes are associated with innate lymphoid cells 3 (ILC3) and may pose threats to the fetus if disregulated.

  8. New Physics in $e^+e^- \\rightarrow Z \\gamma$ at the ILC with polarized beams: Explorations beyond conventional anomalous triple gauge boson coupling

    CERN Document Server

    Ananthanarayan, B; Patra, Monalisa; Rindani, Saurabh D

    2014-01-01

    One of the most-studied signals for physics beyond the standard model in the production of gauge bosons in electron-positron collisions is that due to the anomalous triple gauge boson couplings in the $Z \\gamma$ final state. In this work, we study the implications of this at the ILC with polarized beams for signals that go beyond traditional anomalous triple neutral gauge boson couplings. Here we report a dimension-8 CP-conserving $Z \\gamma Z$ vertex that has not found mention in the literature. We carry out a systematic study of the anomalous couplings in general terms and arrive at a classification. We then obtain linear-order distributions with and without CP violation. Furthermore, we place the study in the context of general BSM interactions represented by $e^+e^- Z \\gamma$ contact interactions. We set up a correspondence between the triple gauge boson couplings and the four-point contact interactions. We also present sensitivities on these anomalous couplings, which will be achievable at the ILC with re...

  9. Q0 Improvement of Large-Grain Multi-Cell Cavities by Using JLab's Standard ILC EP Processing

    Energy Technology Data Exchange (ETDEWEB)

    Geng, R. L. [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Eremeev, G. V. [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Kneisel, P. [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Liu, K. X. [IHIP, Peking University, Beijing (China); Lu, X. Y. [IHIP, Peking University, Beijing (China); Zhao, K. [IHIP, Peking University, Beijing (China)

    2011-07-01

    As reported previously at the Berlin workshop, applying the JLab standard ILC electropolishing (EP) recipe on previously buffered chemical polishing (BCP) etched fine-grain multi-cell cavities results in improvement both in gradient and Q{sub 0}. We recently had the opportunity to experiment with two 1300 MHz 9-cell large-gain niobium cavities manufactured by JLab and Peking University. Both cavities were initially BCP etched and further processed by using JLab's standard ILC EP recipe. Due to fabrication defects, these two cavities only reached a gradient in the range of 20-30 MV/m. Interestingly both cavities demonstrated significant Q{sub 0} improvement in the gradient range of 15-20 MV/m. At 2K, a Q{sub 0} value of 2E10 is achieved at 20 MV/m. At a reduced temperature of 1.8K, a Q{sub 0} value of 3E10 is achieved at 20 MV/m. These results suggest that a possible path for obtaining higher Q{sub 0} in the medium gradient range is to use the large-grain material for cavity fabrication and EP and low temperature bake for cavity processing.

  10. Associated production of the doubly-charged scalar pair with the Higgs boson in the Georgi–Machacek model at the ILC

    Directory of Open Access Journals (Sweden)

    Yi Yu

    2016-08-01

    Full Text Available Besides the SM-like Higgs boson h, the Georgi–Machacek (GM model predicts the existence of doubly-charged Higgs bosons H5±± in the 5-plet representation, which can be seen the typical particles in this model. We first used the latest Higgs boson diphoton signal strength data to find the allowed region at 2σ confidence level on the plane of the scalar mass values mH and the triple scalar coupling parameter ghHH, and then focus on the study of the triple Higgs production process e+e−→hH5++H5−− at the future International Linear collider (ILC. Our numerical results show that, the values of the production cross section are very sensitive to the triple Higgs coupling strength ghHH and can reach the level several fb in the reasonable parameter space. Considering the same-sign diboson decay H5±±→W±W±, the expected discovery reach at the future ILC experiments are also studied.

  11. Native CB1 receptor affinity, intrinsic activity and accumbens shell dopamine stimulant properties of third generation SPICE/K2 cannabinoids: BB-22, 5F-PB-22, 5F-AKB-48 and STS-135.

    Science.gov (United States)

    De Luca, Maria Antonietta; Castelli, M Paola; Loi, Barbara; Porcu, Alessandra; Martorelli, Mariella; Miliano, Cristina; Kellett, Kathryn; Davidson, Colin; Stair, Jacqueline L; Schifano, Fabrizio; Di Chiara, Gaetano

    2016-06-01

    In order to investigate the in vivo dopamine (DA) stimulant properties of selected 3rd generation Spice/K2 cannabinoids, BB-22, 5F-PB-22, 5F-AKB-48 and STS-135, their in vitro affinity and agonist potency at native rat and mice CB1 receptors was studied. The compounds bind with high affinity to CB1 receptors in rat cerebral cortex homogenates and stimulate CB1-induced [(35)S]GTPγS binding with high potency and efficacy. BB-22 and 5F-PB-22 showed the lowest Ki of binding to CB1 receptors (0.11 and 0.13 nM), i.e., 30 and 26 times lower respectively than that of JWH-018 (3.38 nM), and a potency (EC50, 2.9 and 3.7 nM, respectively) and efficacy (Emax, 217% and 203%, respectively) as CB1 agonists higher than JWH-018 (EC50, 20.2 nM; Emax, 163%). 5F-AKB-48 and STS-135 had higher Ki for CB1 binding, higher EC50 and lower Emax as CB1 agonists than BB-22 and 5F-PB-22 but still comparatively more favourable than JWH-018. The agonist properties of all the compounds were abolished or drastically reduced by the CB1 antagonist/inverse agonist AM251 (0.1 μM). No activation of G-protein was observed in CB1-KO mice. BB-22 (0.003-0.01 mg/kg i.v.) increased dialysate DA in the accumbens shell but not in the core or in the medial prefrontal cortex, with a bell shaped dose-response curve and an effect at 0.01 mg/kg and a biphasic time-course. Systemic AM251 (1.0 mg/kg i.p.) completely prevented the stimulant effect of BB-22 on dialysate DA in the NAc shell. All the other compounds increased dialysate DA in the NAc shell at doses consistent with their in vitro affinity for CB1 receptors (5F-PB-22, 0.01 mg/kg; 5F-AKB-48, 0.1 mg/kg; STS-135, 0.15 mg/kg i.v.). 3rd generation cannabinoids can be even more potent and super-high CB1 receptor agonists compared to JWH-018. Future research will try to establish if these properties can explain the high toxicity and lethality associated with these compounds.

  12. Exploration of horizontal intrinsic spin resonances with two partial Siberian snakes

    Science.gov (United States)

    Lin, F.; Ahrens, L. A.; Bai, M.; Brown, K.; Courant, E. D.; Gardner, C.; Glenn, J. W.; Huang, H.; Lee, S. Y.; Luccio, A. U.; Mackay, W. W.; Ptitsyn, V.; Roser, T.; Takano, J.; Tepikian, S.; Tsoupas, N.; Zelenski, A.; Zeno, K.

    2007-04-01

    Two partial Siberian snakes were used to avoid all the spin imperfection and vertical intrinsic resonances in the alternating gradient synchrotron (AGS) at Brookhaven National Laboratory. However, the horizontal betatron motion can cause polarization loss resulting from the nonvertical stable spin direction in the presence of two partial snakes. This type of resonance, called a horizontal intrinsic spin resonance, was observed and systematically studied in the AGS. A simplified analytic model and numerical simulation have been developed to compare with experimental data. Properties of the horizontal intrinsic resonance are discussed.

  13. Exploration of horizontal intrinsic spin resonances with two partial Siberian snakes

    Directory of Open Access Journals (Sweden)

    F. Lin

    2007-04-01

    Full Text Available Two partial Siberian snakes were used to avoid all the spin imperfection and vertical intrinsic resonances in the alternating gradient synchrotron (AGS at Brookhaven National Laboratory. However, the horizontal betatron motion can cause polarization loss resulting from the nonvertical stable spin direction in the presence of two partial snakes. This type of resonance, called a horizontal intrinsic spin resonance, was observed and systematically studied in the AGS. A simplified analytic model and numerical simulation have been developed to compare with experimental data. Properties of the horizontal intrinsic resonance are discussed.

  14. Algebraic description of intrinsic modes in nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Leviatan, A.

    1989-01-01

    We present a procedure for extracting normal modes in algebraic number-conserving systems of interacting bosons relevant for collective states in even-even nuclei. The Hamiltonian is resolved into intrinsic (bandhead related) and collective (in-band related) parts. Shape parameters are introduced through non-spherical boson bases. Intrinsic modes decoupled from the spurious modes are obtained from the intinsic part of the Hamiltonian in the limit of large number of bosons. Intrinsic states are constructed and serve to evaluate electromagnetic transition rates. The method is illustrated for systems with one type of boson as well as with proton-neutron bosons. 28 refs., 1 fig.

  15. First principles predictions of intrinsic defects in aluminum arsenide, AlAs : numerical supplement.

    Energy Technology Data Exchange (ETDEWEB)

    Schultz, Peter Andrew

    2012-04-01

    This Report presents numerical tables summarizing properties of intrinsic defects in aluminum arsenide, AlAs, as computed by density functional theory. This Report serves as a numerical supplement to the results published in: P.A. Schultz, 'First principles predictions of intrinsic defects in Aluminum Arsenide, AlAs', Materials Research Society Symposia Proceedings 1370 (2011; SAND2011-2436C), and intended for use as reference tables for a defect physics package in device models.

  16. Property.

    Science.gov (United States)

    Piele, Philip K.

    Chapter 7 of a book on school law, this chapter deals with 1979 cases involving disputes over property. Cases involving taxpayer attempts to prevent the construction of school buildings dominate this year's property chapter, as they did last year's. Yet, paradoxically, there is also a significant increase in cases in which taxpayers tried to…

  17. Intrinsic stress analysis of sputtered carbon film

    Institute of Scientific and Technical Information of China (English)

    Liqin Liu; Zhanshan Wang; Jingtao Zhu; Zhong Zhang; Moyan Tan; Qiushi Huang; Rui Chen; Jing Xu; Lingyan Chen

    2008-01-01

    Intrinsic stresses of carbon films deposited by direct current (DC) magnetron sputtering were investigated.The bombardments of energetic particles during the growth of films were considered to be the main reason for compressive intrinsic stresses.The values of intrinsic stresses were determined by measuring the radius of curvature of substrates before and after film deposition.By varying argon pressure and target-substrate distance,energies of neutral carbon atoms impinging on the growing films were optimized to control the intrinsic stresses level.The stress evolution in carbon films as a function of film thickness was investigated and a void-related stress relief mechanism was proposed to interpret this evolution.

  18. Original Paper Detecting Nosocomial Intrinsic Infections through ...

    African Journals Online (AJOL)

    2011-04-20

    Apr 20, 2011 ... Micro-organisms from intrinsic and extrinsic sources have .... All isolates with similar antibiotic profile were analysed for ... microcentrifuge at 12,000rpm for 10 minutes. The ..... emphasising the need to remove urinary catheters.

  19. RUSSIAN STUDENTS’ INTRINSIC MOTIVATION: RESEARCH AND DEVELOPMENT

    OpenAIRE

    SHAROVATOVA S.A.

    2015-01-01

    The article is aimed at analysing Russian teachers’ experience in developing students’ intrinsic motivation. The author’s own reflections and findings based on motivation theory and practice are also given.

  20. The Nonlinear Evolution of Galaxy Intrinsic Alignments

    OpenAIRE

    Lee, Jounghun; Pen, Ue-Li

    2007-01-01

    The non-Gaussian contribution to the intrinsic halo spin alignments is analytically modeled and numerically detected. Assuming that the growth of non-Gaussianity in the density fluctuations caused the tidal field to have nonlinear-order effect on the orientations of the halo angular momentum, we model the intrinsic halo spin alignments as a linear scaling of the density correlations on large scales, which is different from the previous quadratic-scaling model based on the linear tidal torque ...