Stability constants of salicylate of zinc(II), cobalt(II), uranyl(II) and thorium(IV) by paper electrophoresis

International Nuclear Information System (INIS)

Singh, R.K.P.; Yadava, J.R.; Yadava, P.C.; Yadava, K.L.

1983-01-01

Stability constants of zinc(II), cobalt(II), uranyl(II) and thorium(IV) have been determined by paper electrophoresis. Salicylic acid (0.005 mol dm - 3 ) was added to the background electrolyte: 0.1 mol dm - 3 HClO 4 . The proportions of C 6 H 4 OHCOO - and C 6 H 4 OCOO/sup =/ were varied by changing the pH of the electrolyte. These anions yielded the complexes, ZnC 6 H 4 OHCOO + , CoC 6 H 4 OHCOO + , Th(C 6 H 4 OHCOO) 4 and UO 2 (C 6 H 4 OCOO) 2 /sup =/ whose stability constants are found to be 10/sup 3.1/, 10/sup 3.2/, 10/sup 11.6/ and 10/sup 22.2/, respectively (μ = 0.1, temp. 40 0 C). (author)

Non-LTE equivalent widths for Si II, III and IV

International Nuclear Information System (INIS)

Becker, S.R.; Butler, K.

1990-01-01

Equivalent widths for a set of Si II, III and IV lines reliable for the determination of temperatures in the B star parameter range are given. They are calculated on a fine grid of LTE line blanketed model atmospheres and lie in the wavelength region from 4070 A to 5070 A

Extraction behaviour and mechanism of Pt(iv) and Pd(ii) by liquid-liquid extraction with an ionic liquid [HBBIm]Br.

Science.gov (United States)

Liu, Wenhui; Wang, Qi; Zheng, Yan; Wang, Shubin; Yan, Yan; Yang, Yanzhao

2017-06-06

In this study, a method of one-step separation and recycling of high purity Pd(ii) and Pt(iv) using an ionic liquid, 1-butyl-3-benzimidazolium bromate ([HBBIm]Br), was investigated. The effects of [HBBIm]Br concentration, initial metal concentration, and loading capacity of [HBBIm]Br were examined in detail. It was observed that [HBBIm]Br was a very effective extractant for selectively extracting Pd(ii) and precipitating Pt(iv). Through selectively extracting Pd(ii) and precipitating Pt(iv), each metal with high purity was separately obtained from mixed Pd(ii) and Pt(iv) multi-metal solution. The method of one-step separation of Pd(ii) and Pt(iv) is simple and convenient. The anion exchange mechanism between [HBBIm]Br and Pt(iv) was proven through Job's method and FTIR and 1 H NMR spectroscopies. The coordination mechanism between [HBBIm]Br and Pd(ii) was demonstrated via single X-ray diffraction and was found to be robust and distinct, as supported by the ab initio quantum-chemical studies. The crystals of the [PdBr 2 ·2BBIm] complex were formed first. Moreover, the influence of the concentrations of hydrochloric acid, sodium chloride, and sodium nitrate on the precipitation of Pt(iv) and extraction of Pd(ii) was studied herein. It was found that only the concentration of H + could inhibit the separation of Pt(iv) because H + could attract the anion PtCl 6 2- ; thus, the exchange (anion exchange mechanism) between the anions PtCl 6 2- and Br - was prevented. However, both the concentration of H + and Cl - can obviously inhibit the extraction of Pd(ii) because H + and Cl - are the reaction products and increasing their concentration can inhibit the progress of the reaction (coordination mechanism).

Effect of HCl Concentration on the Oxidation of LIX 63 and the Subsequent Separation of Pd(II), Pt(IV), Ir(IV) and Rh(III) by Solvent Extraction

Energy Technology Data Exchange (ETDEWEB)

Nguyen, Thi Hong; Lee, Man Seung [Mokpo National University, Jeollanamdo (Korea, Republic of)

2016-10-15

During the selective extraction of Pd(II) by LIX 63 from 6 M HCl solutions containing platinum group metals, an oxidation-reduction reaction occurs between the LIX 63 and Ir(IV). Since the reduced Ir(III) cannot be extracted by solvating and amine extractants, the oxidation-reduction reaction has a significant effect on the separation of Pt(IV), Ir(IV) and Rh(III). Therefore, the effect of HCl concentration on the reduction of Ir(IV) during the extraction with LIX 63 was investigated at 3 and 6 M HCl solutions. The extraction behavior of Iridium by Aliquat 336 from the Pd(II) free raffinate showed that the percentage of iridium extraction rapidly decreased when HCl concentration was increased from 3 to 6 M, indicating that more Ir(IV) was reduced to Ir(III). Extraction schemes for the separation of Pt(IV), iridium and Rh(III) by Aliquat 336 from 3 and 6 M HCl solutions were investigated.

Methylation of class II transactivator gene promoter IV is not associated with susceptibility to Multiple Sclerosis

Directory of Open Access Journals (Sweden)

Lincoln Matthew R

2008-07-01

Full Text Available Abstract Background Multiple sclerosis (MS is a complex trait in which alleles at or near the class II loci HLA-DRB1 and HLA-DQB1 contribute significantly to genetic risk. The MHC class II transactivator (MHC2TA is the master controller of expression of class II genes, and methylation of the promoter of this gene has been previously been shown to alter its function. In this study we sought to assess whether or not methylation of the MHC2TA promoter pIV could contribute to MS disease aetiology. Methods In DNA from peripheral blood mononuclear cells from a sample of 50 monozygotic disease discordant MS twins the MHC2TA promoter IV was sequenced and analysed by methylation specific PCR. Results No methylation or sequence variation of the MHC2TA promoter pIV was found. Conclusion The results of this study cannot support the notion that methylation of the pIV promoter of MHC2TA contributes to MS disease risk, although tissue and timing specific epigenetic modifications cannot be ruled out.

The tarantula toxins ProTx-II and huwentoxin-IV differentially interact with human Nav1.7 voltage sensors to inhibit channel activation and inactivation.

Science.gov (United States)

Xiao, Yucheng; Blumenthal, Kenneth; Jackson, James O; Liang, Songping; Cummins, Theodore R

2010-12-01

The voltage-gated sodium channel Na(v)1.7 plays a crucial role in pain, and drugs that inhibit hNa(v)1.7 may have tremendous therapeutic potential. ProTx-II and huwentoxin-IV (HWTX-IV), cystine knot peptides from tarantula venoms, preferentially block hNa(v)1.7. Understanding the interactions of these toxins with sodium channels could aid the development of novel pain therapeutics. Whereas both ProTx-II and HWTX-IV have been proposed to preferentially block hNa(v)1.7 activation by trapping the domain II voltage-sensor in the resting configuration, we show that specific residues in the voltage-sensor paddle of domain II play substantially different roles in determining the affinities of these toxins to hNa(v)1.7. The mutation E818C increases ProTx-II's and HWTX-IV's IC(50) for block of hNa(v)1.7 currents by 4- and 400-fold, respectively. In contrast, the mutation F813G decreases ProTx-II affinity by 9-fold but has no effect on HWTX-IV affinity. It is noteworthy that we also show that ProTx-II, but not HWTX-IV, preferentially interacts with hNa(v)1.7 to impede fast inactivation by trapping the domain IV voltage-sensor in the resting configuration. Mutations E1589Q and T1590K in domain IV each decreased ProTx-II's IC(50) for impairment of fast inactivation by ~6-fold. In contrast mutations D1586A and F1592A in domain-IV increased ProTx-II's IC(50) for impairment of fast inactivation by ~4-fold. Our results show that whereas ProTx-II and HWTX-IV binding determinants on domain-II may overlap, domain II plays a much more crucial role for HWTX-IV, and contrary to what has been proposed to be a guiding principle of sodium channel pharmacology, molecules do not have to exclusively target the domain IV voltage-sensor to influence sodium channel inactivation.

Crystal chemistry of M{sup II}M′{sup IV}(PO{sub 4}){sub 2} double monophosphates

Energy Technology Data Exchange (ETDEWEB)

Bregiroux, Damien, E-mail: damien.bregiroux@upmc.fr [Sorbonne Universités, UPMC Univ Paris 06, CNRS, Collège de France, Laboratoire de Chimie de la Matière Condensée de Paris, 11 place Marcelin Berthelot, 75005 Paris (France); Popa, Karin [“Al.I. Cuza” University, Department of Chemistry, 11-Carol I Blvd., 700506 Iasi (Romania); Wallez, Gilles [Institut de Recherche de Chimie Paris (IRCP), CNRS – Chimie ParisTech – Paris Sciences et Lettres PSL UMR8247, 11 rue Pierre et Marie Curie, 75005 Paris (France); Sorbonne Universités, UPMC Univ Paris 06 (France)

2015-10-15

M{sup II}M′{sup IV}(PO{sub 4}){sub 2} compounds have been extensively studied for several decades for their potential applications in the field of several domains such as matrices for actinides conditioning, phosphors etc. In this paper, the relationships between composition and crystal structure of these compounds are established. A review of the various processes used for the synthesis of these compounds is also proposed, as well as their most reported properties. M{sup II}M′{sup IV}(PO{sub 4}){sub 2} structures stem from two different archetypes: the cheralite and the yavapaiite structures, with some exceptions that are also described in this article. The ratio of the cations radii appears to be the most relevant parameter. The high ratio between the ionic radii of the divalent and tetravalent cations in yavapaiite derivates results in the ordering of these cations into well-differentiated polyhedra whereas cheralite is the only non-ordered structure encountered for M{sup II}M′{sup IV}(PO{sub 4}){sub 2} compounds. - Graphical abstract: In this paper, the relationships between composition and crystal structure of M{sup II}M′{sup IV}(PO{sub 4}){sub 2} compounds are established. A review of the various processes used for the synthesis of these compounds is also proposed, as well as their most reported properties. - Highlights: • Crystal structure–composition relationships of MIIM′IV(PO4)2 compounds. • Review of the various processes used for the synthesis of these compounds. • Their most reported properties are described and discussed.

Directions for attractive tokamak reactors: The ARIES-II and ARIES-IV second-stability designs

International Nuclear Information System (INIS)

Najmabadi, F.; Conn, R.W.

1993-01-01

ARIES is a research program to develop several visions of tokamak reactors with enhanced economic, safety, and environmental features. The ARIES study has developed four visions for tokamaks. All four designs are steady-state, 1000-MWe (net) power reactors. The ARIES-II and ARIES-IV designs assume potential advances in plasma physics (such as second-stability operation) predicted by theory but not yet established experimentally. The two designs have the same fusion plasma but different fusion-power-core. There are only minor differences between the ARIES-II and ARIES-IV plasma parameters. ARIES-IV is a 1000-MWe reactor with an average neutron wall loading of 3 MW/m 2 , and a mass power density of about 120 kWe/tonne of fusion power core. The reactor major radius is 6.1 m, the plasma minor radius is 1.5 m and the plasma elongation is 2, and the plasma triangularity is 0.67. The plasma current is low (6.8 MA), B on-axis is 7.7 T (corresponding to a maximum field at the coil of 16T), and the toroidal beta is 3.4% (Troyon coefficient = 6). The operating regime is optimized such that most of the plasma current (∼ 90%) is provided by the bootstrap current. ARIES-II uses liquid lithium as the coolant and tritium breeder. V-5Cr-5Ti is used as the structural material so that the potential of low-activation metallic blankets can be studied. ARIES-IV uses helium as the coolant, a solid tritium-breeding material (Li 2 O), and silicon carbide composite as structural material. The waste produced by neutron activation in both designs is found to meet the criteria allowing shallow-land burial under U.S. regulations. The cost of electricity for the ARIES-II-IV class of reactors is estimated to be about 20% lower than comparable, steady-state first-stability reactors (e.g. ARIES-I). 25 refs, 2 figs, 1 tab

Amine extraction of lead(II) and zirconium(IV) with succinate media

International Nuclear Information System (INIS)

Mahamuni, S.V.; Mane, C.P.; Sargar, B.M.; Rajmane, M.M.; Anuse, M.A.

2004-01-01

Lead is an important constituent of various alloys, which are in increasing demand in manufacture of batteries and nuclear shielding while the use of zirconium in nuclear power plants as entirely cladding uranium fuel is most important. This study was carried out to optimize the extraction conditions for Pb(II) and zirconium(IV)

The Belle II Experiment

CERN Document Server

Kahn, J

2017-01-01

Set to begin data taking at the end of 2018, the Belle II experiment is the next-generation B-factory experiment hosted at KEK in Tsukuba, Japan. The experiment represents the cumulative effort from the collaboration of experimental and detector physics, computing, and software development. Taking everything learned from the previous Belle experiment, which ran from 1998 to 2010, Belle II aims to probe deeper than ever before into the field of heavy quark physics. By achieving an integrated luminosity of 50 ab−1 and accumulating 50 times more data than the previous experiment across its lifetime, along with a rewritten analysis framework, the Belle II experiment will push the high precision frontier of high energy physics. This paper will give an overview of the key components and development activities that make the Belle II experiment possible.

WISC-IV and WIAT-II Profiles in Children with High-Functioning Autism

Science.gov (United States)

Mayes, Susan Dickerson; Calhoun, Susan L.

2008-01-01

Children with high-functioning autism earned above normal scores on the Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV) Perceptual Reasoning and Verbal Comprehension Indexes and below normal scores on the Working Memory and Processing Speed Indexes and Wechsler Individual Achievement Test-Second Edition (WIAT-II) Written…

Hexacoordinated mixed-ligand complexes of vanadium(IV) and copper(II)

International Nuclear Information System (INIS)

Islam, M.S.; Motahera Begum; Roy, H.N.; Haroon, S.A.Q.M.

1996-01-01

The literature reports simple complexes of metal ions with Schiff bases derived from amino acids. But their mixed-ligand complexes are very rare. Keeping this fact in mind, some new mixed ligand complexes of V IV and Cu II with tridentate Schiff bases derived from glycine, salicylaldehyde and amino bases, e.g. quinoline (Q), isoquinoline (IQ), 2-picoline (2-pic), 4-picoline (4-pic) and pyridine (Py) were prepared and studied. 6 refs., 1 tab

Thai Undergraduate Chemistry Practical Learning Experiences Using the Jigsaw IV Method

Science.gov (United States)

Jansoon, Ninna; Somsook, Ekasith; Coll, Richard K.

2008-01-01

The research reported in this study consisted of an investigation of student learning experiences in Thai chemistry laboratories using the Jigsaw IV method. A hands-on experiment based on the Jigsaw IV method using a real life example based on green tea beverage was designed to improve student affective variables for studying topics related to…

Syntheses of polystyrene supported chelating resin containing the Schiff base derived from salicylaldehyde and triethylene tetramine and its copper(II), nickel(II), cobalt(II), iron(III), zinc(II), cadmium(II), molybdenum(VI), zirconium(IV) and uranium(VI) complexes

International Nuclear Information System (INIS)

Syamal, A.; Singh, M.M.

1998-01-01

A new polymer-anchored chelating ligand has been synthesized by the reaction of chloromethylated polystyrene (containing 0.94 mmol of Cl per gram of resin and 1% cross-linked with divinylbenzene) and the Schiff base derived from salicylaldehyde and triethylenetetramine. A new series of polystyrene supported, Cu(II), Ni(II), Co(II), Fe(III), Zn(II), Cd(II), Zr(IV), dioxomolybdenum (VI) and dioxouranium (VI) complexes of the formulae PS-LCu, PS-LNi, PS-LCo, PS-LFeCl.DMF, PS-LZn, PS-LCd, PS-LZr(OH) 2 . DMF, PS L MoO 2 and PS-LUO 2 (where PS-LH 2 = polymer-anchored Schiff base and DMF dimethyl-formamide) have been synthesized and characterised by elemental analysis, infrared, electronic spectra and magnetic susceptibility measurements. The complexes PS-LCu, PS-LNi and PS-LCo have square planar structure, PS-LFeCl.DMF, PS-LMoO 2 and PS-LUO 2 have octahedral structure, PS L Zn and PS-LCd are tetrahedral and PS-LZr(OH) 2 .DMF is pentagonal bipyramidal. The polymer-anchored Cu(II), Co(II) and Fe(III) complexes are paramagnetic while Ni(II), Zn(II), Cd(II), Zr(IV), dioxomolybdenum(VI) and dioxouranium(VI) complexes are diamagnetic. The negative shift of the v (C=N) (azomethine) and the positive shift of v (C--O)(phenolic) are indicative of ONNO donor behaviour of the polymer-anchored Schiff base. (author)

Behaviour of palladium(II), platinum(IV), and rhodium(III) in artificial and natural waters: Influence of reactor surface and geochemistry on metal recovery

Energy Technology Data Exchange (ETDEWEB)

Cobelo-Garcia, Antonio [School of Earth, Ocean and Environmental Sciences, University of Plymouth, Drake Circus, Plymouth PL4 8AA (United Kingdom)]. E-mail: antonio.cobelo-garcia@plymouth.ac.uk; Turner, Andrew [School of Earth, Ocean and Environmental Sciences, University of Plymouth, Drake Circus, Plymouth PL4 8AA (United Kingdom); Millward, Geoffrey E. [School of Earth, Ocean and Environmental Sciences, University of Plymouth, Drake Circus, Plymouth PL4 8AA (United Kingdom); Couceiro, Fay [School of Earth, Ocean and Environmental Sciences, University of Plymouth, Drake Circus, Plymouth PL4 8AA (United Kingdom)

2007-03-07

The recovery of dissolved platinum group elements (PGE: Pd(II), Pt(IV) and Rh(III)) added to Milli-Q[reg] water, artificial freshwater and seawater and filtered natural waters has been studied, as a function of pH and PGE concentration, in containers of varying synthetic composition. The least adsorptive and/or precipitative loss was obtained for borosilicate glass under most of the conditions employed, whereas the greatest loss was obtained for low-density polyethylene. Of the polymeric materials tested, the adsorptive and/or precipitative loss of PGE was lowest for fluorinated ethylene propylene (Teflon[reg]). The loss of Pd(II) in freshwater was significant due to its affinity for surface adsorption and its relatively low solubility. The presence of natural dissolved organic matter increases the recovery of Pd(II) but enhances the loss of Pt(IV). The loss of Rh(III) in seawater was significant and was mainly due to precipitation, whereas Pd(II) recovery was enhanced, compared to freshwater, because of its complexation with chloride. The results have important implications regarding protocols employed for sample preservation and controlled laboratory experiments used in the study of the speciation and biogeochemical behaviour of PGE.

Technical realisation of the VISA-II project, phase I, part IV, IZ-165-o268-1962; Tehnicka realizacija projekta VISA-II, I faza (I-V), IV deo, IZ-165-o268-1962

Energy Technology Data Exchange (ETDEWEB)

Pavicevic, M [Institute of Nuclear Sciences Boris Kidric, Vinca, Beograd (Serbia and Montenegro)

1962-12-15

Project VISA-II is described in IX chapters as follows: introduction, definition of experiments and possibilities of performance; VISA-II channel, new experimental space in the RA reactor; hydraulic tests in the VISA-II channel; measurement of fast neutron and gamma flux in VISA-II channels; measurement of water flow through different VISA-2 irradiation capsules; fabrication of VISA-II capsules; corrosion and heavy water purity problems; safety problems of experiment VISA-2; experimental operation of VISA-II. This chapter VI includes documentation for each type of capsule, review about each experiment within the VISA-II project, the objective and purpose of the experiment as well as experimental device. [Serbo-Croat] Projekat VISA-2 opisan je u sledecih IX poglavlja: uvod, definicija eksperimenta VISA-2 i mogucnost njegovog izvodjenja; kanal VISA-2 novi eksperimentalni prostor u reaktoru RA; hidraulicna ispitivanja na tehnoloskom kanalu VISA-2; Realizacija merenja fluksa brzih neutrona i gama zracenja u kanalima VISA-2; merenje protoka vode kroz razne tipove kapsula VISA-2; Kapsule VISA-2 i njihova realizacija; problemi korozije i cistoce teske vode u projektu VISA-2; problemi sigurnosti eksperimenta VISA-2; probni pogon eksperimenta VISA-2. Ova VI glava elaborata sadrzi dokumentaciju za svaku vrstu kapsula, preglednu sliku o svakom eksperimentu u okviru projekta VISA-2, o njegovom cilju i nameni kao i o eksperimentalnom uredjaju.

A DEEP NARROWBAND IMAGING SEARCH FOR C iv AND He ii EMISSION FROM Lyα BLOBS

International Nuclear Information System (INIS)

Battaia, Fabrizio Arrigoni; Yang, Yujin; Hennawi, Joseph F.; Prochaska, J. Xavier; Matsuda, Yuichi; Yamada, Toru; Hayashino, Tomoki

2015-01-01

We conduct a deep narrowband imaging survey of 13 Lyα blobs (LABs) located in the SSA22 proto-cluster at z ∼ 3.1 in the C iv and He ii emission lines in an effort to constrain the physical process powering the Lyα emission in LABs. Our observations probe down to unprecedented surface brightness (SB) limits of (2.1–3.4) × 10 −18 erg s −1 cm −2 arcsec −2 per 1 arcsec 2 aperture (5σ) for the He ii λ1640 and C iv λ1549 lines, respectively. We do not detect extended He ii and C iv emission in any of the LABs, placing strong upper limits on the He ii/Lyα and C iv/Lyα line ratios, of 0.11 and 0.16, for the brightest two LABs in the field. We conduct detailed photoionization modeling of the expected line ratios and find that, although our data constitute the deepest ever observations of these lines, they are still not deep enough to rule out a scenario where the Lyα emission is powered by the ionizing radiation from an obscured active galactic nucleus. Our models can accommodate He ii/Lyα and C iv/Lyα ratios as low as ≃0.05 and ≃0.07, respectively, implying that one needs to reach SB as low as (1–1.5) × 10 −18 erg s −1 cm −2 arcsec −2  (at 5σ) in order to rule out a photoionization scenario. These depths will be achievable with the new generation of image-slicing integral field units such as the Multi Unit Spectroscopic Explorer (MUSE) on VLT and the Keck Cosmic Web Imager (KCWI). We also model the expected He ii/Lyα and C iv/Lyα in a different scenario, where Lyα emission is powered by shocks generated in a large-scale superwind, but find that our observational constraints can only be met for shock velocities v s ≳ 250 km s −1 , which appear to be in conflict with recent observations of quiescent kinematics in LABs

Electromigration techniques for Ge(II) and Ge(IV) separation in germanium thio compounds

International Nuclear Information System (INIS)

Facetti, J.F.; Vallejos, A.

1971-01-01

Using H.V. electromigration techniques, a good separation of the Ge(II) and Ge(IV) was achieved. The procedure was carried out in alkaline medium. And the final position of the separated species was established by, either neutron activation of the papa strips or chromatic reactions

Electromigration techniques for Ge(II) and Ge(IV) separation in germanium thio compounds

Energy Technology Data Exchange (ETDEWEB)

Facetti, J F; Vallejos, A [Asuncion Naciona Univ. (Paraguay). Inst. de Ciencias

1971-01-01

Using H.V. electromigration techniques, a good separation of the Ge(II) and Ge(IV) was achieved. The procedure was carried out in alkaline medium. And the final position of the separated species was established by, either neutron activation of the papa strips or chromatic reactions.

Organic derivatives of tin (II/IV): Investigation of their structure

Energy Technology Data Exchange (ETDEWEB)

Szirtes, L., E-mail: szirtes@iki.kfki.h [Institute of Isotopes of the Hungarian Academy of Sciences, Budapest H-1525, P.O. Box 77 (Hungary); Megyeri, J., E-mail: megyeri@iki.kfki.h [Institute of Isotopes of the Hungarian Academy of Sciences, Budapest H-1525, P.O. Box 77 (Hungary); Kuzmann, E. [Laboratory of Nuclear Chemistry, CRC of the Hungarian Academy of Science at Eoetvoes University, H-1518 Budapest, P.O. Box 32 (Hungary); Beck, A. [Institute of Isotopes of the Hungarian Academy of Sciences, Budapest H-1525, P.O. Box 77 (Hungary)

2011-07-15

The structures of tin(II)-oxalate, tin(IV)Na-EDTA and tin(IV)Na{sub 8}-inositol hexaphosphate were investigated using XRD analysis. Samples were identified using the Moessbauer study, thermal analysis and FTIR spectrometry. The Moessbauer study determined two different oxidation states of tin atoms, and consequently two different tin surroundings in the end products. The tin oxalate was found to be orthorhombic with space group Pnma, a=9.2066(3) A, b=9.7590(1) A, c=13.1848(5) A, V=1184.62 A{sup 3} and Z=8. SnNa-EDTA was found to be monoclinic with space group P2{sub 1}/c{sub 1}, a=10.7544(3) A, b=10.1455(3) A, c=16.5130(6) A, {beta}=98.59(2){sup o}, V=1781.50(4) A{sup 3} and Z=4. Sn(C{sub 6}H{sub 6}Na{sub 8}O{sub 24}P{sub 6}) was found to be amorphous.

A Caenorhabditis elegans RNA polymerase II gene, ama-1 IV, and nearby essential genes.

Science.gov (United States)

Rogalski, T M; Riddle, D L

1988-01-01

The amanitin-binding subunit of RNA polymerase II in Caenorhabditis elegans is encoded by the ama-1 gene, located approximately 0.05 map unit to the right of dpy-13 IV. Using the amanitin-resistant ama-1(m118) strain as a parent, we have isolated amanitin-sensitive mutants that carry recessive-lethal ama-1 alleles. Of the six ethyl methanesulfonate-induced mutants examined, two are arrested late in embryogenesis. One of these is a large deficiency, mDf9, but the second may be a novel point mutation. The four other mutants are hypomorphs, and presumably produce altered RNA polymerase II enzymes with some residual function. Two of these mutants develop into sterile adults at 20 degrees but are arrested as larvae at 25 degrees, and two others are fertile at 20 degrees and sterile at 25 degrees. Temperature-shift experiments performed with the adult sterile mutant, ama-1(m118m238ts), have revealed a temperature-sensitive period that begins late in gonadogenesis and is centered around the initiation of egg-laying. Postembryonic development at 25 degrees is slowed by 30%. By contrast, the amanitin-resistant allele of ama-1 has very little effect on developmental rate or fertility. We have identified 15 essential genes in an interval of 4.5 map units surrounding ama-1, as well as four gamma-ray-induced deficiencies and two duplications that include the ama-1 gene. The larger duplication, mDp1, may include the entire left arm of chromosome IV, and it recombines with the normal homologue at a low frequency. The smallest deficiency, mDf10, complements all but three identified genes: let-278, dpy-13 and ama-1, which define an interval of only 0.1 map unit. The terminal phenotype of mDf10 homozygotes is developmental arrest during the first larval stage, suggesting that there is sufficient maternal RNA polymerase II to complete embryonic development.

A DEEP NARROWBAND IMAGING SEARCH FOR C iv AND He ii EMISSION FROM Lyα BLOBS

Energy Technology Data Exchange (ETDEWEB)

Battaia, Fabrizio Arrigoni; Yang, Yujin; Hennawi, Joseph F. [Max-Planck-Institut für Astronomie, Königstuhl 17, D-69117 Heidelberg (Germany); Prochaska, J. Xavier [Department of Astronomy and Astrophysics, University of California, 1156 High Street, Santa Cruz, California 95064 (United States); Matsuda, Yuichi [National Astronomical Observatory of Japan, 2-21-1 Osawa, Mitaka, Tokyo 181-8588 (Japan); Yamada, Toru [Astronomical Institute, Tohoku University, Aramaki, Aoba-ku, Sendai, Miyagi 980-8578 (Japan); Hayashino, Tomoki, E-mail: arrigoni@mpia.de [Research Center for Neutrino Science, Graduate School of Science, Tohoku University, Sendai 980-8578 (Japan)

2015-05-01

We conduct a deep narrowband imaging survey of 13 Lyα blobs (LABs) located in the SSA22 proto-cluster at z ∼ 3.1 in the C iv and He ii emission lines in an effort to constrain the physical process powering the Lyα emission in LABs. Our observations probe down to unprecedented surface brightness (SB) limits of (2.1–3.4) × 10{sup −18} erg s{sup −1} cm{sup −2} arcsec{sup −2} per 1 arcsec{sup 2} aperture (5σ) for the He ii λ1640 and C iv λ1549 lines, respectively. We do not detect extended He ii and C iv emission in any of the LABs, placing strong upper limits on the He ii/Lyα and C iv/Lyα line ratios, of 0.11 and 0.16, for the brightest two LABs in the field. We conduct detailed photoionization modeling of the expected line ratios and find that, although our data constitute the deepest ever observations of these lines, they are still not deep enough to rule out a scenario where the Lyα emission is powered by the ionizing radiation from an obscured active galactic nucleus. Our models can accommodate He ii/Lyα and C iv/Lyα ratios as low as ≃0.05 and ≃0.07, respectively, implying that one needs to reach SB as low as (1–1.5) × 10{sup −18} erg s{sup −1} cm{sup −2} arcsec{sup −2} (at 5σ) in order to rule out a photoionization scenario. These depths will be achievable with the new generation of image-slicing integral field units such as the Multi Unit Spectroscopic Explorer (MUSE) on VLT and the Keck Cosmic Web Imager (KCWI). We also model the expected He ii/Lyα and C iv/Lyα in a different scenario, where Lyα emission is powered by shocks generated in a large-scale superwind, but find that our observational constraints can only be met for shock velocities v{sub s} ≳ 250 km s{sup −1}, which appear to be in conflict with recent observations of quiescent kinematics in LABs.

Experience with advanced driver fuels in EBR-II

International Nuclear Information System (INIS)

Lahm, C.E.; Koenig, J.F.; Pahl, R.G.; Porter, D.L.; Crawford, D.C.

1992-01-01

The Experimental Breeder Reactor II (EBR-II) is a complete nuclear power plant, incorporating a pool-type liquid-metal reactor (LMR) with a fuel-power thermal output of 62.5 MW and an electrical output of 20 MW. Initial criticality was in 1961, utilizing a metallic driver fuel design called the Mark-I. The fuel design has evolved over the last 30 yr, and significant progress has been made on improving performance. The first major innovations were incorporated into the Mark-II design, and burnup then increased dramatically. This design performed successfully, and fuel element lifetime was limited by subassembly hardware performance rather than the fuel element itself. Transient performance of the fuel was also acceptable and demonstrated the ability of EBR-II to survive severe upsets such as a loss of flow without scram. In the mid 1980s, with renewed interest in metallic fuels and Argonne's integral fast reactor (IFR) concept, the Mark-II design was used as the basis for new designs, the Mark-III and Mark-IV. In 1987, the Mark-III design began qualification testing to become a driver fuel for EBR-II. This was followed in 1989 by the Mark-IIIA and Mark-IV designs. The next fuel design, the Mark-V, is being planned to demonstrate the utilization of recycled fuel. The fuel cycle facility attached to EBR-II is being refurbished to produce pyroprocessed recycled fuel as part of the demonstration of the IFR

Cobalt(II), nickel(II), copper(II), zinc(II) and hafnium(IV) complexes of N'-(furan-3-ylmethylene)-2-(4-methoxyphenylamino)acetohydrazide.

Science.gov (United States)

Emam, Sanaa M; El-Saied, Fathy A; Abou El-Enein, Saeyda A; El-Shater, Heba A

2009-03-01

Cobalt(II), nickel(II), copper(II), zinc(II) and hafnium(IV) complexes of furan-2-carbaldehyde 4-methoxy-N-anilinoacetohydrazone were synthesized and characterized by elemental and thermal (TG and DTA) analyses, IR, UV-vis and (1)H NMR spectra as well as magnetic moment and molar conductivity. Mononuclear complexes are obtained with 1:1 molar ratio except complexes 3 and 9 which are obtained with 1:2 molar ratios. The IR spectra of ligand and metal complexes reveal various modes of chelation. The ligand behaves as a neutral bidentate one and coordination occurs via the carbonyl oxygen atom and azomethine nitrogen atom. The ligand behaves also as a monobasic tridentate one and coordination occurs through the enolic oxygen atom, azomethine nitrogen atom and the oxygen atom of furan ring. Moreover, the ligand behaves as a neutral tridentate and coordination occurs via the carbonyl oxygen, azomethine nitrogen and furan oxygen atoms as well as a monobasic bidentate and coordination occurs via the enolic oxygen atom and azomethine nitrogen atom. The electronic spectra and magnetic moment measurements reveal that all complexes possess octahedral geometry except the copper complex 10 possesses a square planar geometry. The thermal studies showed the type of water molecules involved in metal complexes as well as the thermal decomposition of some metal complexes.

Comparison of the toxicity of the dyes Sudan II and Sudan IV to catalase.

Science.gov (United States)

Li, Tong; Hao, Minglu; Pan, Jie; Zong, Wansong; Liu, Rutao

2017-10-01

The mechanisms of the toxicity of Sudan dyes to the key antioxidant enzyme catalase (CAT) were investigated by spectroscopic methods, calorimetry techniques, enzyme activity assay, and molecular docking. Results showed that Sudan dyes bound to CAT through hydrophobic force, which changed the microenvironment of tryptophan and tyrosine residues, leading to a conformational alteration and shrinkage of the protein. Enzyme activity assay and molecular docking revealed that the activity of CAT was slightly inhibited in the presence of Sudan dyes. In comparison, the binding of Sudan II with CAT was slightly stronger than Sudan IV. Also, Sudan II and Sudan IV showed a different impact on the microenvironment of aromatic amino acid residues. But the dyes had very similar effects on conformation and activity of the protein. This work provides an essential reference for the evaluation of Sudan dyes' effects on body's antioxidant defense system and safe use of Sudan dyes. © 2017 Wiley Periodicals, Inc.

Hereditary sensory and autonomic neuropathies: types II, III, and IV

Directory of Open Access Journals (Sweden)

Axelrod Felicia B

2007-10-01

Full Text Available Abstract The hereditary sensory and autonomic neuropathies (HSAN encompass a number of inherited disorders that are associated with sensory dysfunction (depressed reflexes, altered pain and temperature perception and varying degrees of autonomic dysfunction (gastroesophageal reflux, postural hypotention, excessive sweating. Subsequent to the numerical classification of four distinct forms of HSAN that was proposed by Dyck and Ohta, additional entities continue to be described, so that identification and classification are ongoing. As a group, the HSAN are rare diseases that affect both sexes. HSAN III is almost exclusive to individuals of Eastern European Jewish extraction, with incidence of 1 per 3600 live births. Several hundred cases with HSAN IV have been reported. The worldwide prevalence of HSAN type II is very low. This review focuses on the description of three of the disorders, HSAN II through IV, that are characterized by autosomal recessive inheritance and onset at birth. These three forms of HSAN have been the most intensively studied, especially familial dysautonomia (Riley-Day syndrome or HSAN III, which is often used as a prototype for comparison to the other HSAN. Each HSAN disorder is likely caused by different genetic errors that affect specific aspects of small fiber neurodevelopment, which result in variable phenotypic expression. As genetic tests are routinely used for diagnostic confirmation of HSAN III only, other means of differentiating between the disorders is necessary. Diagnosis is based on the clinical features, the degree of both sensory and autonomic dysfunction, and biochemical evaluations, with pathologic examinations serving to further confirm differences. Treatments for all these disorders are supportive.

Biologically relevant mono- and di-nuclear manganese II/III/IV complexes of mononegative pentadentate ligands

DEFF Research Database (Denmark)

Baffert, Carole; Collomb, Marie-Nöelle; Deronzier, Alain

2003-01-01

were characterised by UV-visible spectroscopy, ESI mass spectrometry and cyclic voltammetry. In addition, III-IV and II-III species were electrochemically generated. Thus the new mononegative pentadentate ligand systems display significant flexibility in the range of Mn oxidation states and species...

Topological characterisation and identification of critical domains within glucosyltransferase IV (GtrIV of Shigella flexneri

Directory of Open Access Journals (Sweden)

Nair Anesh

2011-12-01

Full Text Available Abstract Background The three bacteriophage genes gtrA, gtrB and gtr(type are responsible for O-antigen glucosylation in Shigella flexneri. Both gtrA and gtrB have been demonstrated to be highly conserved and interchangeable among serotypes while gtr(type was found to be specific to each serotype, leading to the hypothesis that the Gtr(type proteins are responsible for attaching glucosyl groups to the O-antigen in a site- and serotype- specific manner. Based on the confirmed topologies of GtrI, GtrII and GtrV, such interaction and attachment of the glucosyl groups to the O-antigen has been postulated to occur in the periplasm. Results In this study, the topology of GtrIV was experimentally determined by creating different fusions between GtrIV and a dual-reporter protein, PhoA/LacZ. This study shows that GtrIV consists of 8 transmembrane helices, 2 large periplasmic loops, 2 small cytoplasmic N- and C- terminal ends and a re-entrant loop that occurs between transmembrane helices III and IV. Though this topology differs from that of GtrI, GtrII, GtrV and GtrX, it is very similar to that of GtrIc. Furthermore, both the N-terminal periplasmic and the C-terminal periplasmic loops are important for GtrIV function as shown via a series of loop deletion experiments and the creation of chimeric proteins between GtrIV and its closest structural homologue, GtrIc. Conclusion The current study provides the basis for elucidating the structure and mechanism of action of this important O-antigen modifying glucosyltransferase.

Crystal and morphological phase transformation of Pb(II) to Pb(IV) in chlorinated water

International Nuclear Information System (INIS)

Lytle, Darren A.; White, Colin; Nadagouda, Mallikarjuna N.; Worrall, Adam

2009-01-01

Herein, we show an important transformation of Pb(II) to Pb(IV) in chlorinated water under laboratory conditions. The study results will give an insight toward understanding how corrosion by-products on lead materials found in drinking water distribution systems develop and breakdown with time. The experiments were conducted to elucidate the morphology of lead (IV) oxide mineral transformation from hydrocerussite and its relationship to color change over a period of time. Scanning electron microscopy and transmission electron microscopy were used to describe the surface morphology, shape and size of lead solids. X-ray diffraction (XRD) analysis was performed to determine the mineral structure of lead solids. Solids analysis results were compared over a 14-day period of time to define changes in the crystal structure and morphology of lead solids. XRD analysis results of freshly synthesized lead solids showed that hydrocerussite, [Pb 3 (CO 3 ) 2 (OH) 2 ], was the only lead mineral present. After 14 days, a mixture of cerussite (PbCO 3 ) and α-PbO 2 and β-PbO 2 was present. Lead precipitates, i.e. hydrocerussite changed color from white to reddish brown confirming a transformation of the lead phase with time. This was correlated to a change in morphology from flower shaped crystals to hexagonal bars and submicron particles.

Diversity of the Germination Apparatus in Clostridium botulinum Groups I, II, III and IV

Directory of Open Access Journals (Sweden)

Jason Brunt

2016-10-01

Full Text Available Clostridium botulinum is a highly dangerous pathogen that forms very resistant endospores that are ubiquitous in the environment, and which, under favourable conditions germinate to produce vegetative cells that multiply and form the exceptionally potent botulinum neurotoxin. To improve the control of botulinum neurotoxin-forming clostridia, it is important to understand the mechanisms involved in spore germination. Here we present models for spore germination in C. botulinum based on comparative genomics analyses, with C. botulinum Groups I and III sharing similar pathways, which differ from those proposed for C. botulinum Groups II and IV. All spores germinate in response to amino acids interacting with a germinant receptor, with four types of germinant receptor identified (encoded by various combinations of gerA, gerB and gerC genes (gerX. There are three gene clusters with an ABC-like configuration; ABC gerX1, ABABCB gerX2 and ACxBBB gerX4, and a single CA-B gerX3 gene cluster. Subtypes have been identified for most germinant receptors types, and the individual GerX subunits of each cluster show similar grouping in phylogenetic trees. C. botulinum Group I contained the largest variety of gerX subtypes, with three gerX1, three gerX2 and one gerX3 subtypes, while C. botulinum Group III contained two gerX1 types and one gerX4. C. botulinum Groups II and IV contained a single germinant receptor, gerX3 and gerX1, respectively. It is likely that all four C. botulinum Groups include a SpoVA channel involved in DPA release. The cortex lytic enzymes present in C. botulinum Groups I and III appear to be CwlJ and SleB, while in C. botulinum Groups II and IV, SleC appears to be important.

Effect of process parameters on removal and recovery of Cd(II) and Cu(II) from electroplating wastewater by fixed-bed column of nano-dimensional titanium (IV) oxide agglomerates

CSIR Research Space (South Africa)

Debnath, S

2014-01-01

Full Text Available Removal performances of Cd(II) and Cu(II) from water was investigated using agglomerated nanoparticle of hydrous titanium(IV) oxide (NTO) packed fixed bed. The parameters varied were the bed depth, flow rate and feed solution concentrations...

Catalytic formal [2+2+1] synthesis of pyrroles from alkynes and diazenes via Ti(II)/Ti(IV) redox catalysis.

Science.gov (United States)

Gilbert, Zachary W; Hue, Ryan J; Tonks, Ian A

2016-01-01

Pyrroles are structurally important heterocycles. However, the synthesis of polysubstituted pyrroles is often challenging. Here, we report a multicomponent, Ti-catalysed formal [2+2+1] reaction of alkynes and diazenes for the oxidative synthesis of penta- and trisubstituted pyrroles: a nitrenoid analogue to classical Pauson-Khand-type syntheses of cyclopentenones. Given the scarcity of early transition-metal redox catalysis, preliminary mechanistic studies are presented. Initial stoichiometric and kinetic studies indicate that the mechanism of this reaction proceeds through a formally Ti(II)/Ti(IV) redox catalytic cycle, in which an azatitanacyclobutene intermediate, resulting from [2+2] alkyne + Ti imido coupling, undergoes a second alkyne insertion followed by reductive elimination to yield pyrrole and a Ti(II) species. The key component for catalytic turnover is the reoxidation of the Ti(II) species to a Ti(IV) imido via the disproportionation of an η(2)-diazene-Ti(II) complex.

Differentiation of grade II/III and grade IV glioma by combining ''T1 contrast-enhanced brain perfusion imaging'' and susceptibility-weighted quantitative imaging

International Nuclear Information System (INIS)

Saini, Jitender; Gupta, Pradeep Kumar; Gupta, Rakesh Kumar; Sahoo, Prativa; Singh, Anup; Patir, Rana; Ahlawat, Suneeta; Beniwal, Manish; Thennarasu, K.; Santosh, Vani

2018-01-01

MRI is a useful method for discriminating low- and high-grade glioma using perfusion MRI and susceptibility-weighted imaging (SWI). The purpose of this study is to evaluate the usefulness of T1-perfusion MRI and SWI in discriminating among grade II, III, and IV gliomas. T1-perfusion MRI was used to measure relative cerebral blood volume (rCBV) in 129 patients with glioma (70 grade IV, 33 grade III, and 26 grade II tumors). SWI was also used to measure the intratumoral susceptibility signal intensity (ITSS) scores for each tumor in these patients. rCBV and ITSS values were compared to seek differences between grade II vs. grade III, grade III vs. grade IV, and grade III+II vs. grade IV tumors. Significant differences in rCBV values of the three grades of the tumors were noted and pairwise comparisons showed significantly higher rCBV values in grade IV tumors as compared to grade III tumors, and similarly increased rCBV was seen in the grade III tumors as compared to grade II tumors (p < 0.001). Grade IV gliomas showed significantly higher ITSS scores on SWI as compared to grade III tumors (p < 0.001) whereas insignificant difference was seen on comparing ITSS scores of grade III with grade II tumors. Combining the rCBV and ITSS resulted in significant improvement in the discrimination of grade III from grade IV tumors. The combination of rCBV values derived from T1-perfusion MRI and SWI derived ITSS scores improves the diagnostic accuracy for discrimination of grade III from grade IV gliomas. (orig.)

Differentiation of grade II/III and grade IV glioma by combining ''T1 contrast-enhanced brain perfusion imaging'' and susceptibility-weighted quantitative imaging

Energy Technology Data Exchange (ETDEWEB)

Saini, Jitender [National Institute of Mental Health and Neurosciences, Neuroimaging and Interventional Radiology, Bangalore (India); Gupta, Pradeep Kumar; Gupta, Rakesh Kumar [Fortis Memorial Research Institute, Department of Radiology and Imaging, Gurugram (India); Sahoo, Prativa [Philips Health System, Philips India Limited, Bangalore (India); Beckman Research Institute, Mathematical Oncology, Duarte, CA (United States); Singh, Anup [Indian Institute of Technology Delhi, Center for Biomedical Engineering, Delhi (India); Patir, Rana [Fortis Memorial Research Institute, Department of Neurosurgery, Gurugram (India); Ahlawat, Suneeta [Fortis Memorial Research Institute, SRL Diagnostics, Gurugram (India); Beniwal, Manish [National Institute of Mental Health and Neurosciences, Department of Neurosurgery, Bangalore (India); Thennarasu, K. [National Institute of Mental Health and Neurosciences, Department of Biostatistics, Bangalore (India); Santosh, Vani [National Institute of Mental Health and Neurosciences, Department of Neuropathology, Bangalore (India)

2018-01-15

MRI is a useful method for discriminating low- and high-grade glioma using perfusion MRI and susceptibility-weighted imaging (SWI). The purpose of this study is to evaluate the usefulness of T1-perfusion MRI and SWI in discriminating among grade II, III, and IV gliomas. T1-perfusion MRI was used to measure relative cerebral blood volume (rCBV) in 129 patients with glioma (70 grade IV, 33 grade III, and 26 grade II tumors). SWI was also used to measure the intratumoral susceptibility signal intensity (ITSS) scores for each tumor in these patients. rCBV and ITSS values were compared to seek differences between grade II vs. grade III, grade III vs. grade IV, and grade III+II vs. grade IV tumors. Significant differences in rCBV values of the three grades of the tumors were noted and pairwise comparisons showed significantly higher rCBV values in grade IV tumors as compared to grade III tumors, and similarly increased rCBV was seen in the grade III tumors as compared to grade II tumors (p < 0.001). Grade IV gliomas showed significantly higher ITSS scores on SWI as compared to grade III tumors (p < 0.001) whereas insignificant difference was seen on comparing ITSS scores of grade III with grade II tumors. Combining the rCBV and ITSS resulted in significant improvement in the discrimination of grade III from grade IV tumors. The combination of rCBV values derived from T1-perfusion MRI and SWI derived ITSS scores improves the diagnostic accuracy for discrimination of grade III from grade IV gliomas. (orig.)

Synthesis and characterization of nickel(II), cobalt(II), copper(II), manganese(II), zinc(II), zirconium(IV), dioxouranium(VI) and dioxomolybdenum(VI) complexes of a new Schiff base derived from salicylaldehyde and 5-methylpyrazole-3-carbohydrazide

International Nuclear Information System (INIS)

Syamal, A.; Maurya, M.R.

1986-01-01

Synthesis of a new Schiff base derived from salicylaldehyde and 5-methylpyrazole-3-carbohydrazide, and its coordination compounds with nickel(II), cobalt(II), copper(II), manganese(II), zinc(II), zirconium(IV), dioxouranium(VI) and dioxomolybdenum(VI) are described. The ligand and the complexes have been characterized on the basis of analytical, conductance, molecular weight, i.r., electronic and n.m.r. spectra and magnetic susceptibility measurements. The stoichiometries of the complexes are represented as NiL . 3H 2 O, CoL . 2H 2 O, CuL, MnL . 2H 2 O, ZnL . H 2 O, Zr(OH) 2 (LH) 2 , Zr(OH) 2 L . 2MeOH, UO 2 L . MeOH and MoO 2 L . MeOH (where LH 2 =Schiff base). The copper(II) complex shows a subnormal magnetic moment due to antiferromagnetic exchange interaction while the nickel(II), cobalt(II) and manganese(II) complexes show normal magnetic moments at room temperature. The i.r. and n.m.r. spectral studies show that the Schiff base behaves as a dibasic and tridentate ligand coordinating through the deprotonated phenolic oxygen, enolic oxygen and azomethine nitrogen. (orig.)

Experiments with radioactive nuclear beams II

International Nuclear Information System (INIS)

Aguilera R, E.F.; Martinez Q, E.; Gomez C, A.; Lizcano C, D.; Garcia M, H.; Rosales M, P.

2001-12-01

The studies of nuclear reactions with heavy ions have been carried out for years for the group of heavy ions of the laboratory of the Accelerator of the ININ. Especially in the last years the group has intruded in the studies of nuclear reactions with radioactive beams, frontier theme at world level. Presently Technical Report is presented in detailed form the experimental methods and the analysis procedures of the research activities carried out by the group. The chpater II is dedicated to the procedures used in the analysis of the last two experiments with radioactive beams carried out by the group. In the chapter III is presented the procedure followed to carrying out an extended analysis with the CCDEF code, to consider the transfer channel of nucleons in the description of the fusion excitation functions of a good number of previously measured systems by the group. Finally, in the chapter IV the more important steps to continue in the study of the reaction 12 C + 12 C experiment drifted to be carried out using the available resources of the Tandem Accelerator Laboratory of the ININ are described. At the end of each chapter some of the more representative results obtained in the analysis are presented and emphasis on the scientific production generated by the group for each case is made. (Author)

Prolyl oligopeptidase and dipeptidyl peptidase II/dipeptidyl peptidase IV ratio in the cerebrospinal fluid in Parkinson's disease: historical overview and future prospects.

Science.gov (United States)

Nagatsu, Toshiharu

2017-06-01

Prolyl oligopeptidase (also named prolyl endopeptidase; PREP) hydrolyzes the Pro-Xaa bonds of biologically active oligopeptides on their carboxyl side. In 1987, we detected PREP activity in human cerebrospinal fluid (CSF) using highly sensitive liquid chromatography-fluorometry with succinyl-Gly-Pro-4-methyl-coumarin amide as a new synthetic substrate, and found a marked decrease in its activity in the cerebrospinal fluid (CSF) from patients with Parkinson's disease (PD) as compared with its level in control patients without neurological diseases. In 2013, Hannula et al. found co-localization of PREP with α-synuclein in the postmortem PD brain. Several recent studies also suggest that the level of PREP in the brain of PD patients may be related to dopamine (DA) cell death via promotion of α-synuclein oligomerization and that inhibitors of PREP may play a neuroprotective role in PD. Although the relationship between another family of prolyl oligopeptidase enzymes, dipeptidyl peptidase II (DPP II) and dipeptidyl peptidase IV (DPP IV), and α-synuclein in the PD brain is not yet clear, we found that the DPP II activity/DPP IV activity ratio in the CSF was significantly increased in PD patients. This review discusses the possibility of PREP as well as the DPP II/DPP IV ratio in the CSF as potential biomarkers of PD.

Differential Relationships between WISC-IV and WIAT-II Scales: An Evaluation of Potentially Moderating Child Demographics

Science.gov (United States)

Konold, Timothy R.; Canivez, Gary L.

2010-01-01

Considerable debate exists regarding the accuracy of intelligence tests with members of different groups. This study investigated differential predictive validity of the "Wechsler Intelligence Scale for Children-Fourth Edition". Participants from the WISC-IV--WIAT-II standardization linking sample (N = 550) ranged in age from 6 through…

Hydrolysis of bis(dimethylamido)tin to tin (II) oxyhydroxide and its selective transformation into tin (II) or tin (IV) oxide

KAUST Repository

Khanderi, Jayaprakash

2015-03-01

Sn6O4(OH)4, a hydrolysis product of Sn(NMe2)2, is transformed to tin (II) or tin (IV) oxide by solid and solution phase processing. Tin (II) oxide is formed by heating Sn6O4(OH)4 at ≤200 °C in air or under inert atmosphere. Tin (IV) oxide nanoparticles are formed in the presence of a carboxylic acid and base in air at room temperature. IR spectroscopy, Raman spectroscopy, thermogravimetry (coupled with infrared spectroscopy), powder X-ray diffraction, high temperature X-ray diffraction, scanning electron and transmission electron microscopy are used for the characterization of Sn6O4(OH)4 and the investigation of its selective decomposition into SnO or SnO2. Spectroscopic and X-ray diffraction results indicate that SnO is formed by the removal of water from crystalline Sn6O4(OH)4. SEM shows octahedral morphology of the Sn6O4(OH)4, SnO and SnO2 with particle size from 400 nm-2 μm during solid state conversion. Solution phase transformation of Sn6O4(OH)4 to SnO2 occurs in the presence of potassium glutarate and oxygen. SnO2 particles are 15-20 nm in size.

Synthesis and characterization of polyacrylamide zirconium (IV iodate ion-exchanger: Its application for selective removal of lead (II from wastewater

Directory of Open Access Journals (Sweden)

Nafisur Rahman

2017-05-01

Full Text Available Polyacrylamide zirconium (IV iodate was synthesized using the sol–gel technique. The synthesis conditions such as reactant concentrations and temperature were changed to optimize the ion exchange properties of the hybrid organic–inorganic ion exchange material. Zirconium oxychloride (0.1 M was added to 0.1 M potassium iodate in the presence of 0.4 M acrylamide and heated at 70 °C for 6 h to yield the polyacrylamide zirconium (IV iodate with maximum capacity. The ion exchange capacity was found to be 3.27 meq/g for Pb(II. The hybrid material has been characterized on the basis of chemical composition FTIR, XRD, TGA-DTA, SEM and EDX studies. Sorption studies showed that the hybrid cation exchanger has a high selectivity to Pb(II in comparison to other metal ions. Its selectivity was evaluated by performing some important binary separations like Hg(II–Pb(II, Cu(II–Pb(II, Ni(II–Pb(II, Fe(III–Pb(II and Cd(II–Pb(II. In addition, the selective separation of Pb(II was also achieved from a synthetic mixture containing a large number of metal ions with a recovery of ∼98.5%. The proposed method was successfully applied for the selective removal of Pb(II from wastewater samples.

Calculated Resonance Line Profiles of [Mg II], [C II], and [Si IV] in the Solar Atmosphere

Science.gov (United States)

Avrett, E.; Landi, E.; McKillop, S.

2013-12-01

NASA's Interface Region Imaging Spectrograph space mission, launched 2013 June 27, is intended to study the structure of the solar chromosphere and the transition region between the chromosphere and corona. The spectral lines to be observed include the Mg II k line at 2796.5 Å, the C II 1334.5 Å line, and the Si IV line at 1393.8 Å, which are formed in the middle chromosphere, the upper chromosphere, and the lower transition region, respectively. Here we calculate the profiles of these lines from four models of the solar atmosphere, intended to represent the faint and mean internetwork, a network lane, and bright network. We show how the profiles change from the center of the solar disk toward the limb of the Sun and in response to outflows and inflows. These results are intended to cover the range of expected quiet-Sun observations and assist in their interpretation. We expect that the observations will lead to improvements in the models, which can then be used to estimate the required non-radiative heating in the different regions.

Calculated resonance line profiles of [Mg II], [C II], and [Si IV] in the solar atmosphere

International Nuclear Information System (INIS)

Avrett, E.; McKillop, S.; Landi, E.

2013-01-01

NASA's Interface Region Imaging Spectrograph space mission, launched 2013 June 27, is intended to study the structure of the solar chromosphere and the transition region between the chromosphere and corona. The spectral lines to be observed include the Mg II k line at 2796.5 Å, the C II 1334.5 Å line, and the Si IV line at 1393.8 Å, which are formed in the middle chromosphere, the upper chromosphere, and the lower transition region, respectively. Here we calculate the profiles of these lines from four models of the solar atmosphere, intended to represent the faint and mean internetwork, a network lane, and bright network. We show how the profiles change from the center of the solar disk toward the limb of the Sun and in response to outflows and inflows. These results are intended to cover the range of expected quiet-Sun observations and assist in their interpretation. We expect that the observations will lead to improvements in the models, which can then be used to estimate the required non-radiative heating in the different regions.

Belle-II Experiment Network Requirements

Energy Technology Data Exchange (ETDEWEB)

Asner, David [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Bell, Greg [ESnet; Carlson, Tim [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Cowley, David [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Dart, Eli [ESnet; Erwin, Brock [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Godang, Romulus [Univ. of South Alabama, Mobile, AL (United States); Hara, Takanori [High Energy Accelerator Research Organization (KEK), Tsukuba (Japan); Johnson, Jerry [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Johnson, Ron [Univ. of Washington, Seattle, WA (United States); Johnston, Bill [ESnet; Dam, Kerstin Kleese-van [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Kaneko, Toshiaki [High Energy Accelerator Research Organization (KEK), Tsukuba (Japan); Kubota, Yoshihiro [NII; Kuhr, Thomas [Karlsruhe Inst. of Technology (KIT) (Germany); McCoy, John [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Miyake, Hideki [High Energy Accelerator Research Organization (KEK), Tsukuba (Japan); Monga, Inder [ESnet; Nakamura, Motonori [NII; Piilonen, Leo [Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States); Pordes, Ruth [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Ray, Douglas [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Russell, Richard [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Schram, Malachi [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Schroeder, Jim [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Sevior, Martin [Univ. of Melbourne (Australia); Singh, Surya [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Suzuki, Soh [High Energy Accelerator Research Organization (KEK), Tsukuba (Japan); Sasaki, Takashi [High Energy Accelerator Research Organization (KEK), Tsukuba (Japan); Williams, Jim [Indiana Univ., Bloomington, IN (United States)

2013-05-28

The Belle experiment, part of a broad-based search for new physics, is a collaboration of ~400 physicists from 55 institutions across four continents. The Belle detector is located at the KEKB accelerator in Tsukuba, Japan. The Belle detector was operated at the asymmetric electron-positron collider KEKB from 1999-2010. The detector accumulated more than 1 ab-1 of integrated luminosity, corresponding to more than 2 PB of data near 10 GeV center-of-mass energy. Recently, KEK has initiated a $400 million accelerator upgrade to be called SuperKEKB, designed to produce instantaneous and integrated luminosity two orders of magnitude greater than KEKB. The new international collaboration at SuperKEKB is called Belle II. The first data from Belle II/SuperKEKB is expected in 2015. In October 2012, senior members of the Belle-II collaboration gathered at PNNL to discuss the computing and neworking requirements of the Belle-II experiment with ESnet staff and other computing and networking experts. The day-and-a-half-long workshop characterized the instruments and facilities used in the experiment, the process of science for Belle-II, and the computing and networking equipment and configuration requirements to realize the full scientific potential of the collaboration's work.

Mandelazo I as a reagent for Zr(IV) determination

International Nuclear Information System (INIS)

Rakha, T.H.; Filip, P.; Stefan, N.

1984-01-01

A spectrometric study of the reaction of the Zr(IV) ions with Mandelazo I was carried out. Absorption spectra revealed that the maximum absorption of the zirconium compound appears at a wavelength (316 nm) different from the maxima of the reagent (253 and 390 nm). Beer-Lambert law is followed for zirconium concentrations of the order of 8.8 x 10 -5 M (i.e. 8 μg Zr(IV)/mL). Possible interferences of ions such as Be(II), Cu(II), Zn(II), Al(III), Th(IV), U(VI), Mn(II), Fe(III), Co(II) and Ni(II) were investigated in connection with some masking agents such as SO 4 2- and C 2 O 4 2- . Also, the solid state Zr(IV)- Mandelazo I compound was prepared and characterized by nitrogen and thermogravimetric analyses

Technical realisation of the VISA-II project, phase I, part IV, IZ-165-o268-1962

International Nuclear Information System (INIS)

Pavicevic, M.

1962-12-01

Project VISA-II is described in IX chapters as follows: introduction, definition of experiments and possibilities of performance; VISA-II channel, new experimental space in the RA reactor; hydraulic tests in the VISA-II channel; measurement of fast neutron and gamma flux in VISA-II channels; measurement of water flow through different VISA-2 irradiation capsules; fabrication of VISA-II capsules; corrosion and heavy water purity problems; safety problems of experiment VISA-2; experimental operation of VISA-II. This chapter VI includes documentation for each type of capsule, review about each experiment within the VISA-II project, the objective and purpose of the experiment as well as experimental device [sr

História de uma experiência singular de ensino – Parte II: o caso das disciplinas “Físicas Básicas”, da UFBA

Directory of Open Access Journals (Sweden)

José Fernando Moura Rocha

2016-09-01

Full Text Available http://dx.doi.org/10.5007/2175-7941.2016v33n2p527   Neste trabalho relata-se uma experiência singular de ensino, realizada no Curso de Física, Licenciatura, noturno, na Universidade Federal da Bahia (UFBA, envolvendo o conteúdo da física universitária básica. Nesta experiência, os conteúdos foram estruturados em bases históricas, pelo menos em sua maior parte, e ministrados através das disciplinas Físicas Básicas I, II, III e IV, segundo uma abordagem simultaneamente histórica, fenomenológica (experimental, matemática e conceitual. Estas disciplinas são oferecidas paralelamente às tradicionais Físicas Gerais e Experimentais I, II, III e IV, que são destinadas aos alunos da área de ciências exatas, inclusive aos alunos da Licenciatura em Física, noturno.

Survival Impact of Adjuvant Radiation Therapy in Masaoka Stage II to IV Thymomas: A Systematic Review and Meta-analysis

International Nuclear Information System (INIS)

Lim, Yu Jin; Kim, Eunji; Kim, Hak Jae; Wu, Hong-Gyun; Yan, Jinchun; Liu, Qin; Patel, Shilpen

2016-01-01

Purpose: To evaluate the survival impact of postoperative radiation therapy (PORT) in stage II to IV thymomas, using systematic review and meta-analysis. Methods and Materials: A database search was conducted with EMBASE, PubMed, Web of Science, Cochrane Library, and Ovid from inception to August 2015. Thymic carcinomas were excluded, and studies comparing overall survival (OS) with and without PORT in thymomas were included. The hazard ratios (HRs) of OS were extracted, and a random-effects model was used in the pooled analysis. Results: Seven retrospective series with a total of 1724 patients were included and analyzed. Almost all of the patients underwent macroscopically complete resection, and thymoma histology was confirmed by the World Health Organization criteria. In the overall analysis of stage II to IV thymomas, OS was not altered with the receipt of PORT (HR 0.79, 95% confidence interval [CI] 0.58-1.08). Although PORT was not associated with survival difference in Masaoka stage II disease (HR 1.45, 95% CI 0.83-2.55), improved OS was observed with the addition of PORT in the discrete pooled analysis of stage III to IV (HR 0.63, 95% CI 0.40-0.99). Significant heterogeneity and publication bias were not found in the analyses. Conclusions: From the present meta-analysis of sole primary thymomas, we suggest the potential OS benefit of PORT in locally advanced tumors with macroscopically complete resection, but not in stage II disease. Further investigations with sufficient survival data are needed to establish detailed treatment indications.

Survival Impact of Adjuvant Radiation Therapy in Masaoka Stage II to IV Thymomas: A Systematic Review and Meta-analysis

Energy Technology Data Exchange (ETDEWEB)

Lim, Yu Jin; Kim, Eunji [Department of Radiation Oncology, Seoul National University College of Medicine, Seoul (Korea, Republic of); Kim, Hak Jae, E-mail: khjae@snu.ac.kr [Department of Radiation Oncology, Seoul National University College of Medicine, Seoul (Korea, Republic of); Wu, Hong-Gyun [Department of Radiation Oncology, Seoul National University College of Medicine, Seoul (Korea, Republic of); Cancer Research Institute, Seoul National University College of Medicine, Seoul (Korea, Republic of); Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul (Korea, Republic of); Yan, Jinchun [Department of Radiation Oncology, Dalian Medical University, Liaoning (China); Department of Radiation Oncology, Fudan University Cancer Hospital, Shanghai (China); Liu, Qin [The Wistar Institute, Philadelphia, Pennsylvania (United States); Patel, Shilpen [Department of Radiation Oncology, University of Washington Medical Center, Seattle, Washington (United States)

2016-04-01

Purpose: To evaluate the survival impact of postoperative radiation therapy (PORT) in stage II to IV thymomas, using systematic review and meta-analysis. Methods and Materials: A database search was conducted with EMBASE, PubMed, Web of Science, Cochrane Library, and Ovid from inception to August 2015. Thymic carcinomas were excluded, and studies comparing overall survival (OS) with and without PORT in thymomas were included. The hazard ratios (HRs) of OS were extracted, and a random-effects model was used in the pooled analysis. Results: Seven retrospective series with a total of 1724 patients were included and analyzed. Almost all of the patients underwent macroscopically complete resection, and thymoma histology was confirmed by the World Health Organization criteria. In the overall analysis of stage II to IV thymomas, OS was not altered with the receipt of PORT (HR 0.79, 95% confidence interval [CI] 0.58-1.08). Although PORT was not associated with survival difference in Masaoka stage II disease (HR 1.45, 95% CI 0.83-2.55), improved OS was observed with the addition of PORT in the discrete pooled analysis of stage III to IV (HR 0.63, 95% CI 0.40-0.99). Significant heterogeneity and publication bias were not found in the analyses. Conclusions: From the present meta-analysis of sole primary thymomas, we suggest the potential OS benefit of PORT in locally advanced tumors with macroscopically complete resection, but not in stage II disease. Further investigations with sufficient survival data are needed to establish detailed treatment indications.

On the line intensity ratios of prominent Si II, Si III, and Si IV multiplets

International Nuclear Information System (INIS)

Djenize, S.; Sreckovic, A.; Bukvic, S.

2010-01-01

Line intensities of singly, doubly and triply ionized silicon (Si II, Si III, and Si IV, respectively) belonging to the prominent higher multiplets, are of interest in laboratory and astrophysical plasma diagnostics. We measured these line intensities in the emission spectra of pulsed helium discharge. The Si II line intensity ratios in the 3s3p 22 D-3s 2 4p 2 P o , 3s 2 3d 2 D-3s 2 4f 2 F o , and 3s 2 4p 2 P o -3s 2 4d 2 D transitions, the Si III line intensity ratios in the 3s3d 3 D-3s4p 3 P o , 3s4p 3 P o -3s4d 3 D, 3s4p 3 P o -3s5s 3 S, 3s4s 3 S-3s4p 3 P o , and 3s4f 3 F o -3s5g 3 G transitions, and the Si IV line intensity ratios in the 4p 2 P o -4d 2 D and 4p 2 P o -5s 2 S transitions were obtained in a helium plasma at an electron temperature of about 17,000 ± 2000 K. Line shapes were recorded using a spectrograph and an ICCD camera as a highly-sensitive detection system. The silicon atoms were evaporated from a Pyrex discharge tube designed for the purpose. They represent impurities in the optically thin helium plasma at the silicon ionic wavelengths investigated. The line intensity ratios obtained were compared with those available in the literature, and with values calculated on the basis of available transition probabilities. The experimental data corresponded well with line intensity ratios calculated using the transition probabilities obtained from a Multi Configuration Hartree-Fock approximation for Si III and Si IV spectra. We recommend corrections of some Si II transition probabilities.

Magneto-structural correlations in a family of Fe(II)Re(IV)(CN)2 single-chain magnets: density functional theory and ab initio calculations.

Science.gov (United States)

Zhang, Yi-Quan; Luo, Cheng-Lin; Wu, Xin-Bao; Wang, Bing-Wu; Gao, Song

2014-04-07

Until now, the expressions of the anisotropic energy barriers Δξ and ΔA, using the uniaxial magnetic anisotropy D, the intrachain coupling strength J, and the high-spin ground state S for single-chain magnets (SCMs) in the intermediate region between the Ising and the Heisenberg limits, were unknown. To explore this relationship, we used density functional theory and ab initio methods to obtain expressions of Δξ and ΔA in terms of D, J, and S of six R4Fe(II)-Re(IV)Cl4(CN)2 (R = diethylformamide (1), dibutylformamide (2), dimethylformamide (3), dimethylbutyramide (4), dimethylpropionamide (5), and diethylacetamide (6)) SCMs in the intermediate region. The ΔA value for compounds 1-3 was very similar to the magnetic anisotropic energy of a single Fe(II), while the value of Δξ was predicted using the exchange interaction of Fe(II) with the neighboring Re(IV), which could be expressed as 2JSReSFe. Similar to compounds 1-3, the anisotropy energy barrier ΔA of compounds 4 and 5 was also equal to (Di - Ei)SFe(2), but the correlation energy Δξ was closely equal to 2JSReSFe(cos 98.4 - cos 180) due to the reversal of the spins on the opposite Fe(II). For compound 6, one unit cell of Re(IV)Fe(II) was regarded as a domain wall since it had two different Re(IV)-Fe(II) couplings. Thus, the Δξ of compound 6 was expressed as 4J″SRe1Fe1SRe2Fe2, where J″ was the coupling constant of the neighboring unit cells of Re1Fe1 and Re2Fe2, and ΔA was equal to the anisotropic energy barrier of one domain wall given by DRe1Fe1(S(2)Re1Fe1 - 1/4).

Experiments with radioactive nuclear beams II; Experimentos con haces nucleares radiactivos II

Energy Technology Data Exchange (ETDEWEB)

Aguilera R, E.F.; Martinez Q, E.; Gomez C, A.; Lizcano C, D.; Garcia M, H.; Rosales M, P. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)

2001-12-15

The studies of nuclear reactions with heavy ions have been carried out for years for the group of heavy ions of the laboratory of the Accelerator of the ININ. Especially in the last years the group has intruded in the studies of nuclear reactions with radioactive beams, frontier theme at world level. Presently Technical Report is presented in detailed form the experimental methods and the analysis procedures of the research activities carried out by the group. The chpater II is dedicated to the procedures used in the analysis of the last two experiments with radioactive beams carried out by the group. In the chapter III is presented the procedure followed to carrying out an extended analysis with the CCDEF code, to consider the transfer channel of nucleons in the description of the fusion excitation functions of a good number of previously measured systems by the group. Finally, in the chapter IV the more important steps to continue in the study of the reaction {sup 12}C + {sup 12}C experiment drifted to be carried out using the available resources of the Tandem Accelerator Laboratory of the ININ are described. At the end of each chapter some of the more representative results obtained in the analysis are presented and emphasis on the scientific production generated by the group for each case is made. (Author)

Effect of amino acid sequence and pH on nanofiber formation of self-assembling peptides EAK16-II and EAK16-IV.

Science.gov (United States)

Hong, Yooseong; Legge, Raymond L; Zhang, S; Chen, P

2003-01-01

Atomic force microscopy (AFM) and axisymmetric drop shape analysis-profile (ASDA-P) were used to investigate the mechanism of self-assembly of peptides. The peptides chosen consisted of 16 alternating hydrophobic and hydrophilic amino acids, where the hydrophilic residues possess alternating negative and positive charges. Two types of peptides, AEAEAKAKAEAEAKAK (EAK16-II) and AEAEAEAEAKAKAKAK (EAK16-IV), were investigated in terms of nanostructure formation through self-assembly. The experimental results, which focused on the effects of the amino acid sequence and pH, show that the nanostructures formed by the peptides are dependent on the amino acid sequence and the pH of the solution. For pH conditions around neutrality, one of the peptides used in this study, EAK16-IV, forms globular assemblies and has lower surface tension at air-water interfaces than another peptide, EAK16-II, which forms fibrillar assemblies at the same pH. When the pH is lowered below 6.5 or raised above 7.5, there is a transition from globular to fibrillar structures for EAK16-IV, but EAK16-II does not show any structural transition. Surface tension measurements using ADSA-P showed different surface activities of peptides at air-water interfaces. EAK16-II does not show a significant difference in surface tension for the pH range between 4 and 9. However, EAK16-IV shows a noticeable decrease in surface tension at pH around neutrality, indicating that the formation of globular assemblies is related to the molecular hydrophobicity.

Interaction between U(VI) and Fe(II) in aqueous solution under anaerobic conditions. Closed system experiments

International Nuclear Information System (INIS)

Myllykylae, E.; Ollila, K.

2011-01-01

The aim of these experiments is to investigate the potential reduction of U(VI) carbonate and hydroxide complexes by aqueous Fe(II). This reduction phenomenon could be important under the disposal conditions of spent fuel. If groundwater enters the copper/iron canister, alpha radiolysis of the water may locally induce oxidizing conditions on the surface of UO 2 fuel, leading to the dissolution of UO 2 as more soluble U(VI) species. A potential reducing agent in the intruding water is Fe(II)(aq) from anaerobic corrosion of the copper/iron canister. The reduction of U(VI) to U(IV) would substantially decrease the solubility of U as well as co-precipitate other actinides and radionuclides. The interaction experiments were conducted in 0.01 M NaCl and 0.002 M NaHCO 3 solutions using an initial uranium concentration of either 8.4 x 10 -8 or 4.2 x 10 -7 mol/L with an initial Fe(II) concentration of 1.8 x 10 -6 in the NaCl solutions and 1.3 x 10 -6 mol/L in the NaHCO 3 solutions. Only after an equilibration period for U(VI) complexation was Fe(II) added to the solutions. The reaction times varied from 1 week to 5 months. For extra protection against O 2 , even inside a glove-box (N 2 atmosphere), the plastic reaction vessels were closed in metallic containers. The concentrations of U, Fe TOT and Fe(II) were analysed as a function of time for unfiltered, micro- and ultrafiltered samples. In addition, the precipitate on the ultrafilters was analysed with ESEM-EDS. The evolution of pH and Eh values was measured. The oxidation state of U in solution was preliminarily analysed for chosen periods. The results of the tests in 0.01 M NaCl showed an initial rapid decrease in U concentration after the addition of Fe(II) to the solution. The U found on test vessel walls at the end of the reaction periods, as well as the ESEM-EDS analyses of the filtered precipitates from the test solutions, showed that precipitation of U had occurred. The oxidation state analyses showed the presence

BigBOSS: The Ground-Based Stage IV BAO Experiment

Energy Technology Data Exchange (ETDEWEB)

Schlegel, David; Bebek, Chris; Heetderks, Henry; Ho, Shirley; Lampton, Michael; Levi, Michael; Mostek, Nick; Padmanabhan, Nikhil; Perlmutter, Saul; Roe, Natalie; Sholl, Michael; Smoot, George; White, Martin; Dey, Arjun; Abraham, Tony; Jannuzi, Buell; Joyce, Dick; Liang, Ming; Merrill, Mike; Olsen, Knut; Salim, Samir

2009-04-01

The BigBOSS experiment is a proposed DOE-NSF Stage IV ground-based dark energy experiment to study baryon acoustic oscillations (BAO) and the growth of structure with an all-sky galaxy redshift survey. The project is designed to unlock the mystery of dark energy using existing ground-based facilities operated by NOAO. A new 4000-fiber R=5000 spectrograph covering a 3-degree diameter field will measure BAO and redshift space distortions in the distribution of galaxies and hydrogen gas spanning redshifts from 0.2< z< 3.5. The Dark Energy Task Force figure of merit (DETF FoM) for this experiment is expected to be equal to that of a JDEM mission for BAO with the lower risk and cost typical of a ground-based experiment.

The BIOPAN experiment MARSTOX II of the FOTON M-3 mission

Science.gov (United States)

Rettberg, P.; Moeller, R.; Rabbow, E.; Panitz, C.; Horneck, G.; Meyer, C.; Lammer, H.; Douki, T.; Cadet, J.

2008-09-01

The experiment MARSTOX II on FOTON M-3 mission (September 14 - 26, 2007) was a further step in the study of the Responses of Organisms to the Martian Environment (ROME) which already started with first ground-based experiments in Mars simulation chambers and with the space experiment MARSTOX I, flown in 2005 in the ESA facility BIOPAN (Fig. 1) on FOTON M-2. The survivability of bacterial spores of B. subtilis, a well-characterized model system for highly resistant microorganisms, was investigated under the extreme environmental conditions as they exist on the surface of Mars. By use of exterrestrial UV radiation and cut-off filters the photoprotection and potential UV-phototoxicity of different minerals of the Martian soil were investigated.In MARSTOX II two further aspects were addressed (i) the influence of different concentrations of dust in the Martian atmosphere, which change the solar irradiance on the surface significantly compared to vacuum exposure under the same conditions (experiment parts 'DUST MARS' and 'DUST SPACE'), and (ii) the survivability of spores under martian atmosphere and pressure exposed to a mars-like spectral irradiance compared to vacuum exposure under the same conditions (experiment parts 'MIXED MARS' and 'MIXED SPACE') (Fig. 2 and 3). After exposure to space during the FOTON M-3 mission the sample analysis was performed at CEA in Grenoble, F, and at DLR in Cologne, D, together with parallel samples from the corresponding ground control experiment performed in the space simulation facilities at DLR. As biological endpoints in these investigations survival and UV-induced DNAphotoproducts were analysed.From the results of MARSTOX II the following conclusions can be drawn: (i) Spores mixed with martian soil analogue are protected only to a low degree against UV radiation. The protective effect of several defined layers of spores mixed with Martian soil analogue were quantified. (ii) The two investigated martian soil analogues, MRS07 (47

Experiment CATETO II

International Nuclear Information System (INIS)

Hendriks, J.A.; Freudenreich, W.E.

1994-03-01

In the irradiation experiment CATETO II different reduced activation (RA) steels will be irradiated up to 2.5 dpa at a temperature of 300 C. The results of the calculation of the nuclear constants, the reactivity effect, and the activity of the steel samples are presented. (orig.)

Raman spectra of Cu{sub 2}B{sup II}C{sup IV}X{sub 4}{sup VI} magnetic quaternary semiconductor compounds with tetragonal stannite type structure

Energy Technology Data Exchange (ETDEWEB)

Rincón, C., E-mail: crincon@ula.ve; Quintero, M.; Power, Ch.; Moreno, E.; Quintero, E.; Morocoima, M. [Centro de Estudios de Semiconductores, Departamento de Física, Facultad de Ciencias, Universidad de Los Andes, Mérida (Venezuela, Bolivarian Republic of); Henao, J. A.; Macías, M. A. [Grupo de Investigación en Química Estructural, Facultad de Ciencias, Escuela de Química, Universidad Industrial de Santander, Apartado Aéreo 678, Bucaramanga (Colombia)

2015-05-28

A comparative study of the Raman spectra of Cu{sub 2}B{sup II}C{sup IV}S{sub 4}{sup VI} and Cu{sub 2}B{sup II}C{sup IV}Se{sub 4}{sup VI}(where B = Mn or Fe) magnetic quaternary semiconductor compounds with stannite-type structure (I4{sup ¯}2m) has been done. Most of the fourteen Raman lines expected for these materials were observed in the spectra. The two strongest lines observed have been assigned to the IR inactive A{sub 1}{sup 1} and A{sub 1}{sup 2} stannite modes that originated from the motion of the S or Se anion around the Cu and C{sup IV} cations remaining at rest. The shift in the frequency of these two lines of about 150 cm{sup −1} to lower energies observed in Cu{sub 2}B{sup II}C{sup IV}Se{sub 4}{sup VI} compounds as compared to those in Cu{sub 2}B{sup II}C{sup IV}S{sub 4}{sup VI} ones, can then be explained as due to the anion mass effect. Based on the fact that values of these frequencies depend mainly on anion mass and bond-stretching forces between nearest-neighbor atoms, the vibrational frequencies v{sup ¯}(A{sub 1}{sup 2}) and v{sup ¯}(A{sub 1}{sup 2}) of both modes for several Cu{sub 2}B{sup II}C{sup IV}X{sub 4}{sup VI} stannite compounds (where X = S, Se, or Te) very close to the experimental data reported for these materials were calculated from a simple model that relates these stretching forces to the anion-cation bond-distances.

Short-interval test-retest interrater reliability of the Dutch version of the structured clinical interview for DSM-IV personality disorders (SCID-II)

NARCIS (Netherlands)

Weertman, A; ArntZ, A; Dreessen, L; van Velzen, C; Vertommen, S

2003-01-01

This study examined the short-interval test-retest reliability of the Structured Clinical Interview (SCID-II: First, Spitzer, Gibbon, & Williams, 1995) for DSM-IV personality disorders (PDs). The SCID-II was administered to 69 in- and outpatients on two occasions separated by 1 to 6 weeks. The

Electronic structure and electric fields gradients of crystalline Sn(II) and Sn(IV) compounds

International Nuclear Information System (INIS)

Terra, J.; Guenzburger, D.

1991-01-01

The electronic structures of clusters representing crystalline compounds of Sn(II) and Sn(IV) were investigated, employing the first-principles Discrete Variational method and Local Density theory. Densities of states and related parameters were obtained and compared with experimental measurements and with results from band structure calculations. Effects of cluster size and of cluster truncated bonds are discussed. Electric field gradients at the Sn nucleus were calculated; results are analysed in terms of charge distribution and chemical bonding in the crystals. (author)

Prophage induction and mutagenicity of a series of anti-tumour platinum(II) and platinum(IV) co-ordination complexes

NARCIS (Netherlands)

Mattern, I.E.; Cocchiarella, L.; Kralingen, C.G. van; Lohman, P.H.M.

1982-01-01

Eleven platinum compounds with nitrogen donor ligands, previously tested for anti-tumour activity were studied for induction of prophage lambda and for mutagenicity in the Ames assay, with various strains of Salmonella. The compounds included cis and trans isomers of Pt(II) and Pt(IV) complexes and

Multisensor system for determination of iron(II), iron(III), uranium(VI) and uranium(IV) in complex solutions

International Nuclear Information System (INIS)

Legin, A.V.; Seleznev, B.L.; Rudnitskaya, A.M.; Vlasov, Yu.G.; Tverdokhlebov, S.V.; Mack, B.; Abraham, A.; Arnold, T.; Baraniak, L.; Nitsche, H.

1999-01-01

Development and analytical evaluation of a multisensor system based on the principles of 'electronic tongue' for the determination of low contents of uranium(VI), uranium(IV), iron(II) and iron(III) in complex aqueous media have been carried out. A set of 29 different chemical sensors on the basis of all- solid-state crystalline and vitreous materials with enhanced electronic conductivity and redox and ionic cross-sensitivity have been incorporated into the sensor array. Multidimensional data have been processed by pattern recognition methods such as artificial neural networks and partial least squares. It has been demonstrated that Fe(II) and Fe(III) contents in the range from 10 -7 to 10 -4 mol L -1 of total iron concentration can be determined with the average precision of about 25 %. U(VI) and U(IV) contents can been determined with the average precision of 10-40% depending on the concentration. The developed multisensor system can be applied in future for the analysis of mining and borehole waters as well other contaminated natural media, including on-site measurements. (author)

Family Caregiver Palliative Care Intervention in Supporting Caregivers of Patients With Stage II-IV Gastrointestinal, Gynecologic, Urologic and Lung Cancers

Science.gov (United States)

2018-02-12

Healthy Subject; Localized Transitional Cell Cancer of the Renal Pelvis and Ureter; Metastatic Transitional Cell Cancer of the Renal Pelvis and Ureter; Psychosocial Effects of Cancer and Its Treatment; Recurrent Bladder Cancer; Recurrent Cervical Cancer; Recurrent Colon Cancer; Recurrent Gastric Cancer; Recurrent Ovarian Epithelial Cancer; Recurrent Ovarian Germ Cell Tumor; Recurrent Pancreatic Cancer; Recurrent Rectal Cancer; Recurrent Renal Cell Cancer; Recurrent Transitional Cell Cancer of the Renal Pelvis and Ureter; Recurrent Urethral Cancer; Recurrent Uterine Sarcoma; Regional Transitional Cell Cancer of the Renal Pelvis and Ureter; Stage II Bladder Cancer; Stage II Renal Cell Cancer; Stage II Urethral Cancer; Stage IIA Cervical Cancer; Stage IIA Colon Cancer; Stage IIA Gastric Cancer; Stage IIA Ovarian Epithelial Cancer; Stage IIA Ovarian Germ Cell Tumor; Stage IIA Pancreatic Cancer; Stage IIA Rectal Cancer; Stage IIA Uterine Sarcoma; Stage IIB Cervical Cancer; Stage IIB Colon Cancer; Stage IIB Gastric Cancer; Stage IIB Ovarian Epithelial Cancer; Stage IIB Ovarian Germ Cell Tumor; Stage IIB Pancreatic Cancer; Stage IIB Rectal Cancer; Stage IIB Uterine Sarcoma; Stage IIC Colon Cancer; Stage IIC Ovarian Epithelial Cancer; Stage IIC Ovarian Germ Cell Tumor; Stage IIC Rectal Cancer; Stage III Bladder Cancer; Stage III Pancreatic Cancer; Stage III Renal Cell Cancer; Stage III Urethral Cancer; Stage IIIA Cervical Cancer; Stage IIIA Colon Cancer; Stage IIIA Gastric Cancer; Stage IIIA Ovarian Epithelial Cancer; Stage IIIA Ovarian Germ Cell Tumor; Stage IIIA Rectal Cancer; Stage IIIA Uterine Sarcoma; Stage IIIB Cervical Cancer; Stage IIIB Colon Cancer; Stage IIIB Gastric Cancer; Stage IIIB Ovarian Epithelial Cancer; Stage IIIB Ovarian Germ Cell Tumor; Stage IIIB Rectal Cancer; Stage IIIB Uterine Sarcoma; Stage IIIC Colon Cancer; Stage IIIC Gastric Cancer; Stage IIIC Ovarian Epithelial Cancer; Stage IIIC Ovarian Germ Cell Tumor; Stage IIIC Rectal Cancer; Stage IIIC

OGLE-IV: Fourth Phase of the Optical Gravitational Lensing Experiment

Science.gov (United States)

Udalski, A.; Szymański, M. K.; Szymański, G.

2015-03-01

We present both the technical overview and main science drivers of the fourth phase of the Optical Gravitational Lensing Experiment (hereafter OGLE-IV). OGLE-IV is currently one of the largest sky variability surveys worldwide, targeting the densest stellar regions of the sky. The survey covers over 3000 square degrees in the sky and monitors regularly over a billion sources. The main targets include the inner Galactic Bulge and the Magellanic System. Their photometry spans the range of 12System and the Galactic disk. OGLE-IV provides the astronomical community with a number of real time services. The Early Warning System (EWS) contains information on two thousand gravitational microlensing events being discovered in real time annually, the OGLE Transient Detection System (OTDS) delivers over 200 supernovae a year. We also provide the real time photometry of unpredictable variables such as optical counterparts to the X-ray sources and R Coronae Borealis stars. Hundreds of thousands new variable stars have already been discovered and classified by the OGLE survey. The number of new detections will be at least doubled during the current OGLE-IV phase. The survey was designed and optimized primarily to conduct the second generation microlensing survey for exoplanets. It has already contributed significantly to the increase of the discovery rate of microlensing exoplanets and free-floating planets.

Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain ii voltage sensor in the closed configuration.

Science.gov (United States)

Xiao, Yucheng; Bingham, Jon-Paul; Zhu, Weiguo; Moczydlowski, Edward; Liang, Songping; Cummins, Theodore R

2008-10-03

Peptide toxins with high affinity, divergent pharmacological functions, and isoform-specific selectivity are powerful tools for investigating the structure-function relationships of voltage-gated sodium channels (VGSCs). Although a number of interesting inhibitors have been reported from tarantula venoms, little is known about the mechanism for their interaction with VGSCs. We show that huwentoxin-IV (HWTX-IV), a 35-residue peptide from tarantula Ornithoctonus huwena venom, preferentially inhibits neuronal VGSC subtypes rNav1.2, rNav1.3, and hNav1.7 compared with muscle subtypes rNav1.4 and hNav1.5. Of the five VGSCs examined, hNav1.7 was most sensitive to HWTX-IV (IC(50) approximately 26 nM). Following application of 1 microm HWTX-IV, hNav1.7 currents could only be elicited with extreme depolarizations (>+100 mV). Recovery of hNav1.7 channels from HWTX-IV inhibition could be induced by extreme depolarizations or moderate depolarizations lasting several minutes. Site-directed mutagenesis analysis indicated that the toxin docked at neurotoxin receptor site 4 located at the extracellular S3-S4 linker of domain II. Mutations E818Q and D816N in hNav1.7 decreased toxin affinity for hNav1.7 by approximately 300-fold, whereas the reverse mutations in rNav1.4 (N655D/Q657E) and the corresponding mutations in hNav1.5 (R812D/S814E) greatly increased the sensitivity of the muscle VGSCs to HWTX-IV. Our data identify a novel mechanism for sodium channel inhibition by tarantula toxins involving binding to neurotoxin receptor site 4. In contrast to scorpion beta-toxins that trap the IIS4 voltage sensor in an outward configuration, we propose that HWTX-IV traps the voltage sensor of domain II in the inward, closed configuration.

Acceptors in II-IV Semiconductors - Incorporation and Complex Formation

CERN Multimedia

2002-01-01

A strong effort is currently devoted to the investigation of defects and the electrical activation of dopant atoms in II-VI semiconductors. In particular, the knowledge about the behaviour of acceptors, prerequisite for the fabrication of p-type semiconductors, is rather limited. The perturbed $\\,{\\gamma\\gamma}$ -angular correlation technique (PAC) and the photoluminescence spectroscopy (PL) using the radioactive isotopes $^{77}\\!$Br and $^{111}\\!$Ag will be applied for investigating the behaviour of acceptor dopant atoms and their interactions with defects in II-VI semiconductors. The main topic will be the identification of the technical conditions for the incorporation of electrically active acceptors in the II-VI semiconductors ~ZnS, ZnSe, ZnTe, CdS, CdSe, and CdTe with particular emphasis on the compounds~ CdTe, ZnSe, and ZnTe. The investigations will be supplemented by first exploratory PL experiments with the group V acceptors $^{71}\\!$As and $^{121}\\!$Sb. With help of the probe $^{111}\\!$Ag, the pos...

Isomer shifts and chemical bonding in crystalline Sn(II) and Sn(IV) compounds

International Nuclear Information System (INIS)

Terra, J.; Guenzburger, D.

1991-01-01

First-principles self-consistent Local Density calculations of the electronic structure of clusters representing Sn(II) (SnO, SnF 2 , SnS, SnSe) and Sn(IV) (SnO 2 , SnF 4 ) crystalline compounds were performed. Values of the electron density at the Sn nucleus were obtained and related to measured values of the Moessbauer Isomer Shifts reported in the literature. The nuclear parameter of 119 Sn derived was ΔR/R=(1.58±0.14)x10 -4 . The chemical bonding in the solids was analysed and related to the electron densities obtained. (author)

Sorption studies of radionuclides on a modified mesoporous cerium(IV) silicate

International Nuclear Information System (INIS)

Sepehrian, H.; Tarbiat Moallem University, Tehran; Ghannadi-Maragheh, M.; Yavari, R.; Khanchi, A.R.; Waqif-Husain, S.

2008-01-01

Five different samples of a new sorbent, modified mesoporous cerium(IV) silicate have been prepared with various mole ratios of Si/Ce and Cetyltrimethylammonium bromide (CTMABr) as template. XRD, nitrogen sorption, SEM, IR, thermogravimetry and sorption of radionuclides have been studied. Separation of Hg(II)-Th(IV), Hg(II)-Zr(IV) and Rb(I)-Zr(IV) have been developed on columns of this novel sorbent. (author)

EBR-II: twenty years of operating experience

International Nuclear Information System (INIS)

Lentz, G.L.; Buschman, H.W.; Smith, R.N.

1985-01-01

Experimental Breeder Reactor No. 2 (EBR-II) is an unmoderated, sodium-cooled reactor with a design power of 62.5 MWt. For the last 20 years EBR-II has operated safely, has demonstrated stable operating characteristics, has shown excellent performance of its sodium components, and has had an excellent plant factor. These years of operating experience provide a valuable resource to the nuclear community for the development and design of future liquid metal fast reactors. This report provides a brief description of the EBR-II plant and its early operating experience, describes some recent problems of interest to the nuclear community, and also mentions some of the significant operating achievements of EBR-II. Finally, a few words and speculations on EBR-II's future are offered. 4 figs., 1 tab

SIMMER-II analysis of transition-phase experiments

International Nuclear Information System (INIS)

Wehner, T.R.; Bell, C.R.

1985-01-01

Analyses of Los Alamos transition-phase experiments with the SIMMER-II computer code are reported. These transient boilup experiments simulated the recriticality-induced transient motion of a boiling pool of molten fuel, molten steel and steel vapor, within a subassembly duct in a liquid-metal fast breeder reactor during the transition phase of a core-disruptive accident. The two purposes of these experiments were to explore and reach a better understanding of fast reactor safety issues, and to provide data for SIMMER-II verification. Experimental data, consisting of four pressure traces and a high-speed movie, were recorded for four sets of initial conditions. For three of the four cases, SIMMER-II-calculated pressures compared reasonably well with the experimental pressures. After a modification to SIMMER-II's liquid-vapor drag correlation, the comparison for the fourth case was reasonable also. 12 refs., 4 figs

The synthesis and properties of some organometallic compounds containing group IV (Ge, Sn)-group II (Zn, Cd) metal---metal bonds

NARCIS (Netherlands)

Des Tombe, F.J.A.; Kerk, G.J.M. van der; Creemers, H.M.J.C.; Carey, N.A.D.; Noltes, J.G.

1972-01-01

The reactions of triphenylgermane and triphenyltin hydride with coordinatively saturated organozinc or organocadmium compounds give organometallic complexes containing Group IV (Ge, Sn)-Group II(Zn, Cd) metal---metal bonds. The 2,2′-bipyridine complexes show solvent-dependent charge-transfer

Recovery of hexagonal Si-IV nanowires from extreme GPa pressure

Energy Technology Data Exchange (ETDEWEB)

Smith, Bennett E. [Department of Chemistry, University of Washington, Seattle, Washington 98195 (United States); Zhou, Xuezhe; Roder, Paden B. [Department of Materials Science and Engineering, University of Washington, Seattle, Washington 98195 (United States); Abramson, Evan H. [Department of Earth and Space Sciences, University of Washington, Seattle, Washington 98195 (United States); Pauzauskie, Peter J., E-mail: peterpz@uw.edu [Department of Materials Science and Engineering, University of Washington, Seattle, Washington 98195 (United States); Fundamental and Computational Sciences Directorate, Pacific Northwest National Laboratory, Richland, Washington 99352 (United States)

2016-05-14

We use Raman spectroscopy in tandem with transmission electron microscopy and density functional theory simulations to show that extreme (GPa) pressure converts the phase of silicon nanowires from cubic (Si-I) to hexagonal (Si-IV) while preserving the nanowire's cylindrical morphology. In situ Raman scattering of the longitudinal transverse optical (LTO) mode demonstrates the high-pressure Si-I to Si-II phase transition near 9 GPa. Raman signal of the LTO phonon shows a decrease in intensity in the range of 9–14 GPa. Then, at 17 GPa, it is no longer detectable, indicating a second phase change (Si-II to Si-V) in the 14–17 GPa range. Recovery of exotic phases in individual silicon nanowires from diamond anvil cell experiments reaching 17 GPa is also shown. Raman measurements indicate Si-IV as the dominant phase in pressurized nanowires after decompression. Transmission electron microscopy and electron diffraction confirm crystalline Si-IV domains in individual nanowires. Computational electromagnetic simulations suggest that heating from the Raman laser probe is negligible and that near-hydrostatic pressure is the primary driving force for the formation of hexagonal silicon nanowires.

Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake.

Science.gov (United States)

Gotoh, Koro; Liu, Min; Benoit, Stephen C; Clegg, Deborah J; Davidson, W Sean; D'Alessio, David; Seeley, Randy J; Tso, Patrick; Woods, Stephen C

2006-01-01

Apolipoprotein (apo) A-IV is an anorexigenic gastrointestinal peptide that is also synthesized in the hypothalamus. The goal of these experiments was to determine whether apo A-IV interacts with the central melanocortin (MC) system in the control of feeding. The third ventricular (i3vt) administration of a subthreshold dose of apo A-IV (0.5 microg) potentiated i3vt MC-induced (metallothionein-II, 0.03 nmol) suppression of 30-min feeding in Long-Evans rats. A subthreshold dose of the MC antagonist (SHU9119, 0.1 nmol, i3vt) completely attenuated the anorectic effect of i3vt apo A-IV (1.5 microg). The i3vt apo A-IV significantly elevated the expression of c-Fos in neurons of the paraventricular nucleus of the hypothalamus, but not in the arcuate nucleus or median eminence. In addition, c-Fos expression was not colocalized with proopiomelanocortin-positive neurons. These data support a synergistic interaction between apo A-IV and melanocortins that reduces food intake by acting downstream of the arcuate.

Nuclear fuel technology - Determination of uranium in solutions, uranium hexafluoride and solids - Part 2: Iron(II) reduction/cerium(IV) oxidation titrimetric method

International Nuclear Information System (INIS)

2004-01-01

This first edition of ISO 7097-1 together with ISO 7097-2:2004 cancels and replaces ISO 7097:1983, which has been technically revised, and ISO 9989:1996. ISO 7097 consists of the following parts, under the general title Nuclear fuel technology - Determination of uranium in solutions, uranium hexafluoride and solids: Part 1: Iron(II) reduction/potassium dichromate oxidation titrimetric method; Part 2: Iron(II) reduction/cerium(IV) oxidation titrimetric method. This part 2. of ISO 7097 describes procedures for determination of uranium in solutions, uranium hexafluoride and solids. The procedures described in the two independent parts of this International Standard are similar: this part uses a titration with cerium(IV) and ISO 7097-1 uses a titration with potassium dichromate

Stability constants of mixed ligand complexes of dioxouranium(II) and thorium(IV) with complexones and isomeric alanines

International Nuclear Information System (INIS)

Singh, R.K.; Saxena, M.C.

1992-01-01

The present work reports on the stability sequence between UO 2 II and Th IV ions for their mixed ligands complexes with the two isomeric alanines, α-alanine (α-ala) and β-alanine (β-ala) containing a complexone as primary ligand. The complexones used are iminodiacetate (IMDA), nitrilotricetate (NTA), 2-hydroxyethylenediaminetriacetate (HEDTA), ethylenediaminetetraacetate (EDTA), 1,2-diaminocyclohexanetraacetate (CDTA) and diethylenetriminepentaacetate (DTPA). (author). 9 refs., 1 tab

Hydrothermal preparation of nickel(II)/uranium(IV) fluorides with one-, two-, and three-dimensional topologies.

Science.gov (United States)

Bean, Amanda C; Sullens, Tyler A; Runde, Wolfgang; Albrecht-Schmitt, Thomas E

2003-04-21

A modified compositional diagram for the reactions of Ni(C(2)H(3)O(2))(2).4H(2)O with UO(2)(C(2)H(3)O(2))(2).2H(2)O and HF in aqueous media under mild hydrothermal conditions (200 degrees C) has been completed to yield three Ni(II)/U(IV) fluorides, Ni(H(2)O)(4)UF(6).1.5H(2)O (1), Ni(2)(H(2)O)(6)U(3)F(16).3H(2)O (2), and Ni(H(2)O)(2)UF(6)(H(2)O) (3). The structure of 1 consists of one-dimensional columns constructed from two parallel chains of edge-sharing dodecahedral [UF(8)] units. The sides of the columns are terminated by octahedral Ni(II) units that occur as cis-[Ni(H(2)O)(4)F(2)] polyhedra. In contrast, the crystal structure of 2 reveals a two-dimensional Ni(II)/U(IV) architecture built from edge-sharing tricapped trigonal prismatic [UF(9)] units. The top and bottom of the sheets are capped by fac-[Ni(H(2)O)(3)F(3)] octahedra. The structure of 3 is formed from [UF(8)(H(2)O)] tricapped trigonal prisms that edge share with one another to form one-dimensional chains. These chains are then joined together into a three-dimensional network by corner sharing with trans-[Ni(H(2)O)(2)F(4)] octahedra. Crystallographic data: 1, orthorhombic, space group Cmcm, a = 14.3383(8) A, b = 15.6867(8) A, c = 8.0282(4) A, Z = 8; 2, hexagonal, space group P6(3)/mmc, a = 7.9863(5) A, c = 16.566(1) A, Z = 2; 3, monoclinic, space group C2/c, a = 12.059(1) A, b = 6.8895(6) A, c = 7.9351(7) A, beta = 92.833(2) degrees, Z = 4.

Consistencia interna del cuestionario autoadministrado de la Entrevista Clínica Estructurada para Trastornos del Eje II del DSM-IV*

OpenAIRE

Campo-Arias, Adalberto; Díaz-Martínez, Luis Alfonso; Barros-Bermúdez, Jaider Alfonso

2008-01-01

Introducción: Es infrecuente identificar posibles casos de trastornos de personalidad en la población general, debido a la carencia de instrumentos autoadministrados con buena validez y confiabilidad. Hasta la fecha no se ha explorado la confiabilidad del cuestionario autoadministrado de la Entrevista Clínica Estructurada para Diagnósticos del eje II (SDID-II) del DSM-IV en la población colombiana. Objetivo: Determinar la consistencia interna de las subescalas del cuestionario autoadministrad...

Granisetron, Aprepitant, and Dexamethasone in Preventing Nausea and Vomiting in Patients Receiving Chemotherapy for Stage II, III, or IV Ovarian Cancer

Science.gov (United States)

2018-04-24

Nausea and Vomiting; Ovarian Brenner Tumor; Ovarian Clear Cell Cystadenocarcinoma; Ovarian Endometrioid Adenocarcinoma; Ovarian Mucinous Cystadenocarcinoma; Ovarian Seromucinous Carcinoma; Ovarian Serous Cystadenocarcinoma; Stage II Ovarian Cancer; Stage IIA Fallopian Tube Cancer; Stage IIA Ovarian Cancer; Stage IIB Fallopian Tube Cancer; Stage IIB Ovarian Cancer; Stage IIC Fallopian Tube Cancer; Stage IIC Ovarian Cancer; Stage IIIA Fallopian Tube Cancer; Stage IIIA Ovarian Cancer; Stage IIIA Primary Peritoneal Cancer; Stage IIIB Fallopian Tube Cancer; Stage IIIB Ovarian Cancer; Stage IIIB Primary Peritoneal Cancer; Stage IIIC Fallopian Tube Cancer; Stage IIIC Ovarian Cancer; Stage IIIC Primary Peritoneal Cancer; Stage IV Fallopian Tube Cancer; Stage IV Ovarian Cancer; Stage IV Primary Peritoneal Cancer; Undifferentiated Ovarian Carcinoma

A transient overpower experiment in EBR-II

International Nuclear Information System (INIS)

Herzog, J.P.; Tsai, H.; Dean, E.M.; Aoyama, T.; Yamamoto, K.

1994-01-01

The TOPI-IE test was a transient overpower test on irradiate mixed-oxide fuel pins in the Experimental Breeder Reactor-II (EBR-II). The test, the fifth in a series, was part of a cooperative program between the US Department of Energy and the Power Reactor and Nuclear Fuel Development Corporation of Japan to conduct operational transient testing on mixed-oxide fuel pins in the metal-fueled EBR-II. The principle objective of the TOPI-1E test was to assess breaching margins for irradiated mixed-oxide fuel pins over the Plant Protection System (PPS) thresholds during a slow, extended overpower transient. This paper describes the effect of the TOPI-1E experiment on reactor components and the impact of the experiment on the long-term operability of the reactor. The paper discusses the role that SASSYS played in the pre-test safety analysis of the experiment. The ability of SASSYS to model transient overpower events is detailed by comparisons of data from the experiment with computed reactor variables from a SASSYS post-test simulation of the experiment

Synthesis, Structure and Investigation of Germanium(IV and Copper(II Complexes with Malic Acid and 1,10ʹ-phenanthroline

Directory of Open Access Journals (Sweden)

Inna Seifullina

2017-12-01

Full Text Available Two crystalline compounds of germanium(IV with malic acid (HMal and 1,10ʹ-phenanthroline (phen - [Ge(HMal2(phen]•pheh•2H2O (I and [CuCl(phen2][Ge(OH(HMal2] (II were synthesized for the first time and characterized by elemental analysis, IR-spectroscopy and thermogravimetric analysis. There was elucidated from single-crystal X-ray diffraction that two different forms of Germanium are implemented: Ge4+ (I and hydrolyzed GeOH3+ (II to form distorted octahedron and pyramid respectively.

IUE observations of interstellar Si IV and C IV lines observed in the spectra of Wolf-Rayet stars

International Nuclear Information System (INIS)

Smith, L.J.; Willis, A.J.; Wilson, R.

1980-01-01

Recent IUE observations of Wolf-Rayet stars show narrow absorption lines in the highly ionized species of Si IV and C IV. The strengths of these 'interstellar' Si IV and C IV lines observed in the spectra of 10 WR stars and two other early-type stars are compared. Of the WR sample, six stars exhibit very strong Si IV and C IV lines (Wsub(lambda) approximately 0.3 to 0.5 A) whilst the other four stars show much weaker lines (Wsub(lambda) approximately 0.1 A). There is no correlation between the strengths of these lines with either stellar distance or colour excess. The weaker absorptions may arise in the individual stellar H II regions, the observed strengths being consistent with those expected for stars with Tsub(eff) = 30 000 K. Five of the other stars which exhibit very strong absorptions lie in the line of sight to active interstellar regions (Cygnus and Carina nebulae) and it is considered probable that, in addition to their H II region components, the bulk of the strong Si IV and C IV absorptions originate in hot gas associated with these active regions. In the case of the WN5 star HD 50896 violet-displaced components are observed in the interstellar lines of low ionization species. These are thought to be produced in the ring nebula S308 surrounding HD 50896. (author)

ERB-II operating experience

International Nuclear Information System (INIS)

Smith, R.N.; Cissel, D.W.; Smith, R.R.

1977-01-01

As originally designed and operated, EBR-II successfully demonstrated the concept of a sodium-cooled fast breeder power plant with a closed fuel reprocessing cycle (mini-nuclear park). Subsequent operation has been as an irradiation facility, a role which will continue into the foreseeable future. Since the beginning of operation in 1961, operating experience of EBR-II has been very satisfactory. Most of the components and systems have performed well. In particular, the mechanical performance of heat-removal systems has been excellent. A review of the operating experience reveals that all the original design objectives have been successfully demonstrated. To date, no failures or incidents resulting in serious in-core or out-of-core consequences have occurred. No water-to-sodium leaks have been detected over the life of the plant. At the present time, the facility is operating very well and continuously except for short shutdowns required by maintenance, refueling, modification, and minor repair. A plant factor of 76.9% was achieved for the calendar year 1976

Analyses of out-of-pile freezing experiments by SIMMER-II

International Nuclear Information System (INIS)

Sawada, Tetsuo; Ninokata, Hisashi

1994-01-01

This paper describes the interpretation of the TRAN Simulation experiments performed by SIMBATH facility of KfK. Two typical TRAN Simulation experiments were analyzed by using the SIMMER-II code. The original TRAN experiments were performed at SNL in order to examine the freezing behavior of molten UO 2 injected into an annular channel. In the TRAN Simulation experiments of SIMBATH series, similar freezing phenomena were investigated for molten thermite, i.e., a mixture of Al 2 O 3 and iron, instead of UO 2 . The analyses of the simulation experiments by SIMMER-II code aimed at clarifying the applicability of the code and interpreting the freezing process during the experiments. Distribution of molten materials that had deposited in the test section was compared between experimental measurements and calculation by SIMMER-II. Through this study, it has been confirmed that SIMMER-II can well reproduce the TRAN Simulation experiments with allowable difference. The calculations by SIMMER-II also suggested that further model improvements, e.g., freezing on a convex surface, would be effective for a better interpretation of the freezing phenomena. (author)

Determination of the O/M ratios of polynary uranium oxides by Ce(IV)-Fe(II) back titration after dissolution in mixed sulphuric and phosphoric acids.

Science.gov (United States)

Fujino, T; Sato, N; Yamada, K

1996-01-01

Uranium (IV) in polynary uranium oxides is determined after the solid has been dissolved in a warm mixed solution of sulphuric and phosphoric acids containing excess Ce(IV). The latter is titrated with a Fe(II) standard solution using ferroin as indicator. This method is especially effective for (mixed) uranium oxides which are difficult to dissolve in hot Ce(IV) sulphuric acid. The standard deviation of the determined x value in polynary oxides is estimated to be below +/- 0.004 for samples of 10-30 mg.

Physicochemical, Spectral, and Biological Studies of Mn(II, Cu(II, Cd(II, Zr(OH2(IV, and UO2(VI Compounds with Ligand Containing Thiazolidin-4-one Moiety

Directory of Open Access Journals (Sweden)

Dinesh Kumar

2014-01-01

Full Text Available The Schiff base (I upon reacting with mercaptoacetic acid in dry benzene undergoes cyclization and forms N-(2-carbamoylthienyl-C-(3′-carboxy-2′-hydroxyphenylthiazolidin-4-one, LH3 (II. A MeOH solution of II reacts with Mn(II, Cu(II, Cd(II, Zr(OH2(IV, and UO2(VI ions and forms the coordination compounds, [Mn(LH(MeOH2], [Cu(LH]2, [Cd(LH], [Zr(OH2(OAc2(LH3], and [UO2(NO3(LH2(MeOH]. The compounds have been characterized on the basis of elemental analyses, molar conductance, molecular weight, spectral (IR, reflectance, and EPR studies and magnetic susceptibility measurements. LH3 behaves as a neutral tridentate ONS donor ligand in [Zr(OH2(OAc2(LH3], monobasic tridentate ONS donor ligand in [UO2(NO3(LH2(MeOH], dibasic tridentate OOS donor ligand in [Cu(LH]2 and dibasic tetradentate OONO donor ligand in [Mn(LH(MeOH2] and [Cd(LH]. [Cu(LH]2 is dimer, while all other compounds are monomers in diphenyl. A square-planar structure for [Cu(LH]2, a tetrahedral structure for [Cd(LH], an octahedral structure for [Mn(LH(MeOH2], a pentagonal-bipyramidal structure for [Zr(OH2(OAc2(LH3], and an eight-coordinate structure for [UO2(NO3(LH2(MeOH] are proposed. The ligand (II and its compounds show antibacterial activities towards E. coli. (Gram negative and S. aureus (Gram positive.

Characterization of a tricationic trigonal bipyramidal iron(IV) cyanide complex, with a very high reduction potential, and its iron(II) and iron(III) congeners.

Science.gov (United States)

England, Jason; Farquhar, Erik R; Guo, Yisong; Cranswick, Matthew A; Ray, Kallol; Münck, Eckard; Que, Lawrence

2011-04-04

Currently, there are only a handful of synthetic S = 2 oxoiron(IV) complexes. These serve as models for the high-spin (S = 2) oxoiron(IV) species that have been postulated, and confirmed in several cases, as key intermediates in the catalytic cycles of a variety of nonheme oxygen activating enzymes. The trigonal bipyramidal complex [Fe(IV)(O)(TMG(3)tren)](2+) (1) was both the first S = 2 oxoiron(IV) model complex to be generated in high yield and the first to be crystallographically characterized. In this study, we demonstrate that the TMG(3)tren ligand is also capable of supporting a tricationic cyanoiron(IV) unit, [Fe(IV)(CN)(TMG(3)tren)](3+) (4). This complex was generated by electrolytic oxidation of the high-spin (S = 2) iron(II) complex [Fe(II)(CN)(TMG(3)tren)](+) (2), via the S = 5/2 complex [Fe(III)(CN)(TMG(3)tren)](2+) (3), the progress of which was conveniently monitored by using UV-vis spectroscopy to follow the growth of bathochromically shifting ligand-to-metal charge transfer (LMCT) bands. A combination of X-ray absorption spectroscopy (XAS), Mössbauer and NMR spectroscopies was used to establish that 4 has a S = 0 iron(IV) center. Consistent with its diamagnetic iron(IV) ground state, extended X-ray absorption fine structure (EXAFS) analysis of 4 indicated a significant contraction of the iron-donor atom bond lengths, relative to those of the crystallographically characterized complexes 2 and 3. Notably, 4 has an Fe(IV/III) reduction potential of ∼1.4 V vs Fc(+/o), the highest value yet observed for a monoiron complex. The relatively high stability of 4 (t(1/2) in CD(3)CN solution containing 0.1 M KPF(6) at 25 °C ≈ 15 min), as reflected by its high-yield accumulation via slow bulk electrolysis and amenability to (13)C NMR at -40 °C, highlights the ability of the sterically protecting, highly basic peralkylguanidyl donors of the TMG(3)tren ligand to support highly charged high-valent complexes.

Bone radioisotope scanning: usefulness in the evaluation and observation of patients with breast cancer in clinical stage II, III, IV; Gammagrafia osea: utilidad en la evaluacion y seguimiento de pacientes con cancer de mama en estadio clinico II, III, IV

Energy Technology Data Exchange (ETDEWEB)

Cano P, R A

1996-12-31

The clinical records of 420 patients with diagnosis of breast cancer well documented by the pathological anatomy in clinical stage II, III and IV were reviewed. In each one of them has been done at least a bone scanning during the diagnosis. In 52 cases carried out sericeous dosages of CA 15-3 and in some cases it was necessary to administer Samarium-153 EDTMP as palliative therapy of bone pain. The presence of secondary gamma-graphic focuses was 0/84 cases (0%) in clinical stage II, 54/265 cases (20%) in III and 41/91 cases (45%) in IV. The one focus appeared in 6.7% of the cases. In 7 of the 52 cases that received sericeous dosages of CA 15-3 were detected secondary osseous lesions, and 5 of them presented a marker elevation. The bone scanning has shown in many cases the presence of getters focuses in singular places of skeleton, urinary excretory system or mammary tissue. The gamma rays from Sm-153 allowed us to get some appropriate basal views post-therapy of the secondary lesions. The results show that the great incidence of secondary lesions in the skeleton occurred in cases of stages III and IV unlike other countries. The serial repetition of the radioisotope scanning. The presence of one focus in the skeleton of a patient with a well-known neoplasia makes us to do a careful evaluation of the focus nature. The presence of tracer accumulation in the kidney, ureter and bladder allows us to infer the pathology of excretory system that is the first evidence of its presence in many cases. (author). 71 refs., 7 figs., 6 tabs.

LMFBR operational safety: the EBR-II experience

International Nuclear Information System (INIS)

Sackett, J.I.; Allen, N.L.; Dean, E.M.; Fryer, R.M.; Larson, H.A.; Lehto, W.K.

1978-01-01

The mission of the Experimental Breeder Reactor II (EBR-II) has evolved from that of a small LMFBR demonstration plant to a major irradiation-test facility. Because of that evolution, many operational-safety issues have been encountered. The paper describes the EBR-II operational-safety experience in four areas: protection-system design, safety-document preparation, tests of off-normal reactor conditions, and tests of elements with breached cladding

Determination of the O/M ratios of polynary uranium oxides by Ce(IV)-Fe(II) back titration after dissolution in mixed sulphuric and phosphoric acids

International Nuclear Information System (INIS)

Fujino, T.; Sato, N.; Yamada, K.

1996-01-01

Uranium (IV) in polynary uranium oxides is determined after the solid has been dissolved in a warm mixed solution of sulphuric and phosphoric acids containing excess Ce(IV). The latter is titrated with a Fe(II) standard solution using ferroin as indicator. This method is especially effective for (mixed) uranium oxides which are difficult to dissolve in hot Ce(IV) sulphuric acid. The standard deviation of the determined x value in polynary oxides is estimated to be below ± 0.004 for samples of 10-30 mg. (orig.)

Plasma opening switch experiments on the Particle Beam Accelerator II

International Nuclear Information System (INIS)

Sweeney, M.A.; McDaniel, D.H.; Mendel, C.W.; Rochau, G.E.; Moore, W.B.S.; Mowrer, G.R.; Simpson, W.W.; Zagar, D.M.; Grasser, T.; McDougal, C.D.

1989-01-01

Plasma opening switch (POS) experiments have been done since 1986 on the PBFA-II ion beam accelerator to develop a rugged POS that will open rapidly ( 80%) into a high impedance (> 10 ohm) load. In a recent series of experiments on PBFA II, the authors have developed and tested three different switch designs that use magnetic fields to control and confine the injected plasma. All three configurations couple current efficiently to a 5-ohm electron beam diode. In this experimental series, the PBFA-II Delta Series, more extensive diagnostics were used than in previous switch experiments on PBFA II or on the Blackjack 5 accelerator at Maxwell Laboratories. Data from the experiments with these three switch designs is presented

Non-equilibrium ionization by a periodic electron beam. II. Synthetic Si IV and O IV transition region spectra

Science.gov (United States)

Dzifčáková, Elena; Dudík, Jaroslav

2018-03-01

Context. Transition region (TR) spectra typically show the Si IV 1402.8 Å line to be enhanced by a factor of 5 or more compared to the neighboring O IV 1401.2 Å, contrary to predictions of ionization equilibrium models and the Maxwellian distribution of particle energies. Non-equilibrium effects in TR spectra are therefore expected. Aims: To investigate the combination of non-equilibrium ionization and high-energy particles, we apply the model of the periodic electron beam, represented by a κ-distribution that recurs at periods of several seconds, to plasma at chromospheric temperatures of 104 K. This simple model can approximate a burst of energy release involving accelerated particles. Methods: Instantaneous time-dependent charge states of silicon and oxygen were calculated and used to synthesize the instantaneous and period-averaged spectra of Si IV and O IV. Results: The electron beam drives the plasma out of equilibrium. At electron densities of Ne = 1010 cm-3, the plasma is out of ionization equilibrium at all times in all cases we considered, while for a higher density of Ne = 1011 cm-3, ionization equilibrium can be reached toward the end of each period, depending on the conditions. In turn, the character of the period-averaged synthetic spectra also depends on the properties of the beam. While the case of κ = 2 results in spectra with strong or even dominant O IV, higher values of κ can approximate a range of observed TR spectra. Spectra similar to typically observed spectra, with the Si IV 1402.8 Å line about a factor 5 higher than O IV 1401.2 Å, are obtained for κ = 3. An even higher value of κ = 5 results in spectra that are exclusively dominated by Si IV, with negligible O IV emission. This is a possible interpretation of the TR spectra of UV (Ellerman) bursts, although an interpretation that requires a density that is 1-3 orders of magnitude lower than for equilibrium estimates. Movies associated to Fig. A.1 are available at http://https://www.aanda.org

Multiepitope fusion antigen induces broadly protective antibodies that prevent adherence of Escherichia coli strains expressing colonization factor antigen I (CFA/I), CFA/II, and CFA/IV.

Science.gov (United States)

Ruan, Xiaosai; Knudsen, David E; Wollenberg, Katie M; Sack, David A; Zhang, Weiping

2014-02-01

Diarrhea is the second leading cause of death in children younger than 5 years and continues to be a major threat to global health. Enterotoxigenic Escherichia coli (ETEC) strains are the most common bacteria causing diarrhea in developing countries. ETEC strains are able to attach to host small intestinal epithelial cells by using bacterial colonization factor antigen (CFA) adhesins. This attachment helps to initiate the diarrheal disease. Vaccines that induce antiadhesin immunity to block adherence of ETEC strains that express immunologically heterogeneous CFA adhesins are expected to protect against ETEC diarrhea. In this study, we created a CFA multiepitope fusion antigen (MEFA) carrying representative epitopes of CFA/I, CFA/II (CS1, CS2, and CS3), and CFA/IV (CS4, CS5, and CS6), examined its immunogenicity in mice, and assessed the potential of this MEFA as an antiadhesin vaccine against ETEC. Mice intraperitoneally immunized with this CFA MEFA exhibited no adverse effects and developed immune responses to CFA/I, CFA/II, and CFA/IV adhesins. Moreover, after incubation with serum of the immunized mice, ETEC or E. coli strains expressing CFA/I, CFA/II, or CFA/IV adhesins were significantly inhibited in adherence to Caco-2 cells. Our results indicated this CFA MEFA elicited antibodies that not only cross-reacted to CFA/I, CFA/II and CFA/IV adhesins but also broadly inhibited adherence of E. coli strains expressing these seven adhesins and suggested that this CFA MEFA could be a candidate to induce broad-spectrum antiadhesin protection against ETEC diarrhea. Additionally, this antigen construction approach (creating an MEFA) may be generally used in vaccine development against heterogenic pathogens.

Respiratory Infections in the U.S. Military: Recent Experience and Control

Science.gov (United States)

Cooper, Michael J.; Myers, Christopher A.; Cummings, James F.; Vest, Kelly G.; Russell, Kevin L.; Sanchez, Joyce L.; Hiser, Michelle J.; Gaydos, Charlotte A.

2015-01-01

SUMMARY This comprehensive review outlines the impact of military-relevant respiratory infections, with special attention to recruit training environments, influenza pandemics in 1918 to 1919 and 2009 to 2010, and peacetime operations and conflicts in the past 25 years. Outbreaks and epidemiologic investigations of viral and bacterial infections among high-risk groups are presented, including (i) experience by recruits at training centers, (ii) impact on advanced trainees in special settings, (iii) morbidity sustained by shipboard personnel at sea, and (iv) experience of deployed personnel. Utilizing a pathogen-by-pathogen approach, we examine (i) epidemiology, (ii) impact in terms of morbidity and operational readiness, (iii) clinical presentation and outbreak potential, (iv) diagnostic modalities, (v) treatment approaches, and (vi) vaccine and other control measures. We also outline military-specific initiatives in (i) surveillance, (ii) vaccine development and policy, (iii) novel influenza and coronavirus diagnostic test development and surveillance methods, (iv) influenza virus transmission and severity prediction modeling efforts, and (v) evaluation and implementation of nonvaccine, nonpharmacologic interventions. PMID:26085551

II-I2-IV-VI4 (II = Sr,Ba; I = Cu,Ag; IV = Ge,Sn; VI = S,Se): Earth-Abundant Chalcogenides for Thin Film Photovoltaics

Science.gov (United States)

Zhu, Tong; Huhn, William P.; Shin, Donghyeop; Mitzi, David B.; Blum, Volker; Saparov, Bayrammurad

Chalcogenides such as CdTe, CIGSSe, and CZTSSe are successful for thin film photovoltaics (PV) but contain elements that are rare, toxic, or prone to the formation of detrimental antisite disorder. Recently, the BaCu2SnS4-xSex system has been shown to offer a prospective path to circumvent these problems. While early prototypes show efficiencies of a few percent, many avenues remain to optimize the materials, including the underlying chemical composition. In this work, we explore 16 compounds II-I2-IV-VI4 to help identify new candidate materials for PV, with predictions based on both known experimental and computationally derived structures that belong to five different space groups. We employ hybrid density functional theory (HSE06) to explore the band gap tunability by substituting different elements, and other characteristics such as the effective mass and the absorption coefficient. Compounds containing Cu (rather than Ag) are found to have direct or nearly direct band gaps. Depending on the compound, replacing S with Se leads to a decrease of the predicted band gaps by 0.2-0.8 eV and to somewhat decreasing hole effective masses.

Recent operating experiences and programs at EBR-II

International Nuclear Information System (INIS)

Lentz, G.L.

1984-01-01

Experimental Breeder Reactor No. II (EBR-II) is a pool-type, unmoderated, sodium-cooled reactor with a design power of 62.5 MWt and an electrical generation capability of 20 MW. It has been operated by Argonne National Laboratory for the US government for almost 20 years. During that time, it has operated safely and has demonstrated stable operating characteristics, high availability, and excellent performance of its sodium components. The 20 years of operating experience of EBR-II is a valuable resource to the nuclear community for the development and design of future LMFBR's. Since past operating experience has been extensively reported, this report will focus on recent programs and events

A new oxidimetric reagent: potassium dichromate in a strong phosphoric acid medium--VII. Photometric titration of vanadium(IV) and of cerium(III) alone and in mixtures with iroN(II).

Science.gov (United States)

Rao, G G; Rao, P K

1967-01-01

Vanadium(IV) can be accurately titrated with potassium dichromate in media containing phosphoric acid of 3-12M concentration: the change in absorption of vanadium(IV) is followed in the region 660 mmicro using a red filter. It is more convenient to carry out the titration in 3M phosphoric acid because at higher concentrations chloride, nitrate, cerium(III) and manganese(II) may interfere. Photoelcetric titration is more convenient than potentiometric because the former can be made in a 3M phosphoric acid medium, whereas the latter is possible only in 12M phosphoric acid. The simultaneous differential photometric titration of iron(II) and vanadium(IV) is also possible. Conditions have been found for the photometric titration of cerium(III) and of cerium(III) plus iron(II). The titration is carried out (at 450 mmicro or with a blue filter) in about 10.5M phosphoric acid. Application of the method to a cerium mineral is considered.

Chemotherapy Toxicity On Quality of Life in Older Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian Epithelial, Primary Peritoneal Cavity, or Fallopian Tube Cancer

Science.gov (United States)

2017-05-03

Stage I Ovarian Cancer; Stage IA Fallopian Tube Cancer; Stage IB Fallopian Tube Cancer; Stage IC Fallopian Tube Cancer; Stage II Ovarian Cancer; Stage IIA Fallopian Tube Cancer; Stage IIB Fallopian Tube Cancer; Stage IIC Fallopian Tube Cancer; Stage III Ovarian Cancer; Stage III Primary Peritoneal Cancer; Stage IIIA Fallopian Tube Cancer; Stage IIIB Fallopian Tube Cancer; Stage IIIC Fallopian Tube Cancer; Stage IV Fallopian Tube Cancer; Stage IV Ovarian Cancer; Stage IV Primary Peritoneal Cancer

Genetic fusions of a CFA/I/II/IV MEFA (multiepitope fusion antigen) and a toxoid fusion of heat-stable toxin (STa) and heat-labile toxin (LT) of enterotoxigenic Escherichia coli (ETEC) retain broad anti-CFA and antitoxin antigenicity.

Science.gov (United States)

Ruan, Xiaosai; Sack, David A; Zhang, Weiping

2015-01-01

Immunological heterogeneity has long been the major challenge in developing broadly effective vaccines to protect humans and animals against bacterial and viral infections. Enterotoxigenic Escherichia coli (ETEC) strains, the leading bacterial cause of diarrhea in humans, express at least 23 immunologically different colonization factor antigens (CFAs) and two distinct enterotoxins [heat-labile toxin (LT) and heat-stable toxin type Ib (STa or hSTa)]. ETEC strains expressing any one or two CFAs and either toxin cause diarrhea, therefore vaccines inducing broad immunity against a majority of CFAs, if not all, and both toxins are expected to be effective against ETEC. In this study, we applied the multiepitope fusion antigen (MEFA) strategy to construct ETEC antigens and examined antigens for broad anti-CFA and antitoxin immunogenicity. CFA MEFA CFA/I/II/IV [CVI 2014, 21(2):243-9], which carried epitopes of seven CFAs [CFA/I, CFA/II (CS1, CS2, CS3), CFA/IV (CS4, CS5, CS6)] expressed by the most prevalent and virulent ETEC strains, was genetically fused to LT-STa toxoid fusion monomer 3xSTaA14Q-dmLT or 3xSTaN12S-dmLT [IAI 2014, 82(5):1823-32] for CFA/I/II/IV-STaA14Q-dmLT and CFA/I/II/IV-STaN12S-dmLT MEFAs. Mice intraperitoneally immunized with either CFA/I/II/IV-STa-toxoid-dmLT MEFA developed antibodies specific to seven CFAs and both toxins, at levels equivalent or comparable to those induced from co-administration of the CFA/I/II/IV MEFA and toxoid fusion 3xSTaN12S-dmLT. Moreover, induced antibodies showed in vitro adherence inhibition activities against ETEC or E. coli strains expressing these seven CFAs and neutralization activities against both toxins. These results indicated CFA/I/II/IV-STa-toxoid-dmLT MEFA or CFA/I/II/IV MEFA combined with 3xSTaN12S-dmLT induced broadly protective anti-CFA and antitoxin immunity, and suggested their potential application in broadly effective ETEC vaccine development. This MEFA strategy may be generally used in multivalent

Genetic fusions of a CFA/I/II/IV MEFA (multiepitope fusion antigen and a toxoid fusion of heat-stable toxin (STa and heat-labile toxin (LT of enterotoxigenic Escherichia coli (ETEC retain broad anti-CFA and antitoxin antigenicity.

Directory of Open Access Journals (Sweden)

Xiaosai Ruan

Full Text Available Immunological heterogeneity has long been the major challenge in developing broadly effective vaccines to protect humans and animals against bacterial and viral infections. Enterotoxigenic Escherichia coli (ETEC strains, the leading bacterial cause of diarrhea in humans, express at least 23 immunologically different colonization factor antigens (CFAs and two distinct enterotoxins [heat-labile toxin (LT and heat-stable toxin type Ib (STa or hSTa]. ETEC strains expressing any one or two CFAs and either toxin cause diarrhea, therefore vaccines inducing broad immunity against a majority of CFAs, if not all, and both toxins are expected to be effective against ETEC. In this study, we applied the multiepitope fusion antigen (MEFA strategy to construct ETEC antigens and examined antigens for broad anti-CFA and antitoxin immunogenicity. CFA MEFA CFA/I/II/IV [CVI 2014, 21(2:243-9], which carried epitopes of seven CFAs [CFA/I, CFA/II (CS1, CS2, CS3, CFA/IV (CS4, CS5, CS6] expressed by the most prevalent and virulent ETEC strains, was genetically fused to LT-STa toxoid fusion monomer 3xSTaA14Q-dmLT or 3xSTaN12S-dmLT [IAI 2014, 82(5:1823-32] for CFA/I/II/IV-STaA14Q-dmLT and CFA/I/II/IV-STaN12S-dmLT MEFAs. Mice intraperitoneally immunized with either CFA/I/II/IV-STa-toxoid-dmLT MEFA developed antibodies specific to seven CFAs and both toxins, at levels equivalent or comparable to those induced from co-administration of the CFA/I/II/IV MEFA and toxoid fusion 3xSTaN12S-dmLT. Moreover, induced antibodies showed in vitro adherence inhibition activities against ETEC or E. coli strains expressing these seven CFAs and neutralization activities against both toxins. These results indicated CFA/I/II/IV-STa-toxoid-dmLT MEFA or CFA/I/II/IV MEFA combined with 3xSTaN12S-dmLT induced broadly protective anti-CFA and antitoxin immunity, and suggested their potential application in broadly effective ETEC vaccine development. This MEFA strategy may be generally used in

Civilians in World War II and DSM-IV mental disorders: Results from the World Mental Health Survey Initiative

Science.gov (United States)

Frounfelker, Rochelle; Gilman, Stephen E.; Betancourt, Theresa S.; Aguilar-Gaxiola, Sergio; Alonso, Jordi; Bromet, Evelyn J.; Bruffaerts, Ronny; de Girolamo, Giovanni; Gluzman, Semyon; Gureje, Oye; Karam, Elie G.; Lee, Sing; Lépine, Jean-Pierre; Ono, Yutaka; Pennell, Beth-Ellen; Popovici, Daniela G.; Have, Margreet ten; Kessler, Ronald C.

2018-01-01

Purpose Understanding the effects of war on mental disorders is important for developing effective post-conflict recovery policies and programs. The current study uses cross-sectional, retrospectively reported data collected as part of the World Mental Health (WMH) Survey Initiative to examine the associations of being a civilian in a war zone/region of terror in World War II with a range of DSM-IV mental disorders. Methods Adults (n= 3,370)who lived in countries directly involved in World War II in Europe and Japan were administered structured diagnostic interviews of lifetime DSM-IV mental disorders. The associations of war-related traumas with subsequent disorder onset-persistence were assessed with discrete-time survival analysis (lifetime prevalence) and conditional logistic regression (12-month prevalence). Results Respondents who were civilians in a war zone/region of terror had higher lifetime risks than other respondents of major depressive disorder (MDD; OR 1.5, 95% CI 1.1, 1.9) and anxiety disorder (OR 1.5, 95% CI 1.1, 2.0). The association of war exposure with MDD was strongest in the early years after the war, whereas the association with anxiety disorders increased over time. Among lifetime cases, war exposure was associated with lower past year risk of anxiety disorders. (OR 0.4, 95% CI 0.2, 0.7). Conclusions Exposure to war in World War II was associated with higher lifetime risk of some mental disorders. Whether comparable patterns will be found among civilians living through more recent wars remains to be seen, but should be recognized as a possibility by those projecting future needs for treatment of mental disorders. PMID:29119266

Civilians in World War II and DSM-IV mental disorders: results from the World Mental Health Survey Initiative.

Science.gov (United States)

Frounfelker, Rochelle; Gilman, Stephen E; Betancourt, Theresa S; Aguilar-Gaxiola, Sergio; Alonso, Jordi; Bromet, Evelyn J; Bruffaerts, Ronny; de Girolamo, Giovanni; Gluzman, Semyon; Gureje, Oye; Karam, Elie G; Lee, Sing; Lépine, Jean-Pierre; Ono, Yutaka; Pennell, Beth-Ellen; Popovici, Daniela G; Ten Have, Margreet; Kessler, Ronald C

2018-02-01

Understanding the effects of war on mental disorders is important for developing effective post-conflict recovery policies and programs. The current study uses cross-sectional, retrospectively reported data collected as part of the World Mental Health (WMH) Survey Initiative to examine the associations of being a civilian in a war zone/region of terror in World War II with a range of DSM-IV mental disorders. Adults (n = 3370) who lived in countries directly involved in World War II in Europe and Japan were administered structured diagnostic interviews of lifetime DSM-IV mental disorders. The associations of war-related traumas with subsequent disorder onset-persistence were assessed with discrete-time survival analysis (lifetime prevalence) and conditional logistic regression (12-month prevalence). Respondents who were civilians in a war zone/region of terror had higher lifetime risks than other respondents of major depressive disorder (MDD; OR 1.5, 95% CI 1.1, 1.9) and anxiety disorder (OR 1.5, 95% CI 1.1, 2.0). The association of war exposure with MDD was strongest in the early years after the war, whereas the association with anxiety disorders increased over time. Among lifetime cases, war exposure was associated with lower past year risk of anxiety disorders (OR 0.4, 95% CI 0.2, 0.7). Exposure to war in World War II was associated with higher lifetime risk of some mental disorders. Whether comparable patterns will be found among civilians living through more recent wars remains to be seen, but should be recognized as a possibility by those projecting future needs for treatment of mental disorders.

Maqarin natural analogue project: Phase IV. Reconnaissance mission report (April 28 to May 7, 1999)

International Nuclear Information System (INIS)

Smellie, J.A.T.

2000-08-01

Final planning of the Technical Proposal for Phase IV of the Maqarin Natural Analogue Project was preceded by a ten day Reconnaissance Mission to the Jordan sites. The main objective of this mission was to: i) allow new organisations within the project to become familiar with the geological context of the Maqarin and Central Jordan sites and also to appreciate the prevailing technical and logistical limitations, ii) carry out limited field investigations, and iii) based on the experience from these two points, provide the opportunity to finalise the Maqarin Phase IV Technical Proposal. This report details the results of the mission

Maqarin natural analogue project: Phase IV. Reconnaissance mission report (April 28 to May 7, 1999)

Energy Technology Data Exchange (ETDEWEB)

Smellie, J.A.T. [ed.] [Conterra AB, Uppsala (Sweden)

2000-08-01

Final planning of the Technical Proposal for Phase IV of the Maqarin Natural Analogue Project was preceded by a ten day Reconnaissance Mission to the Jordan sites. The main objective of this mission was to: i) allow new organisations within the project to become familiar with the geological context of the Maqarin and Central Jordan sites and also to appreciate the prevailing technical and logistical limitations, ii) carry out limited field investigations, and iii) based on the experience from these two points, provide the opportunity to finalise the Maqarin Phase IV Technical Proposal. This report details the results of the mission.

Level II Probabilistic Safety Analysis Methodology for the Application to GEN-IV Sodium-cooled Fast Reactor

International Nuclear Information System (INIS)

Park, S. Y.; Kim, T. W.; Han, S. H.; Jeong, H. Y.

2010-03-01

The Korea Atomic Energy Research Institute (KAERI) has been developing liquid metal reactor (LMR) design technologies under a National Nuclear R and D Program. Nevertheless, there is no experience of the probabilistic safety assessment (PSA) domestically for a fast reactor with the metal fuel. Therefore, the objective of this study is to establish the methodologies of risk assessment for the reference design of GEN-IV sodium fast reactor (SFR). An applicability of the PSA methodology of U. S. NRC and PRISM plant to the domestic GEN-IV SFR has been studied. The study contains a plant damage state analysis, a containment event tree analysis, and a source-term release category binning process

Transoral Robotic Surgery in Treating Patients With Benign or Stage I-IV Head and Neck Cancer

Science.gov (United States)

2014-11-07

Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Lymphoepithelioma of the Oropharynx; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Stage I Adenoid Cystic Carcinoma of the Oral Cavity; Stage I Lymphoepithelioma of the Nasopharynx; Stage I Lymphoepithelioma of the Oropharynx; Stage I Mucoepidermoid Carcinoma of the Oral Cavity; Stage I Squamous Cell Carcinoma of the Hypopharynx; Stage I Squamous Cell Carcinoma of the Larynx; Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage I Squamous Cell Carcinoma of the Nasopharynx; Stage I Squamous Cell Carcinoma of the Oropharynx; Stage I Verrucous Carcinoma of the Larynx; Stage I Verrucous Carcinoma of the Oral Cavity; Stage II Adenoid Cystic Carcinoma of the Oral Cavity; Stage II Lymphoepithelioma of the Nasopharynx; Stage II Lymphoepithelioma of the Oropharynx; Stage II Mucoepidermoid Carcinoma of the Oral Cavity; Stage II Squamous Cell Carcinoma of the Hypopharynx; Stage II Squamous Cell Carcinoma of the Larynx; Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage II Squamous Cell Carcinoma of the Nasopharynx; Stage II Squamous Cell Carcinoma of the Oropharynx; Stage II Verrucous Carcinoma of the Larynx; Stage II Verrucous Carcinoma of the Oral Cavity; Stage III Adenoid Cystic Carcinoma of the Oral Cavity; Stage III Lymphoepithelioma of the Nasopharynx; Stage III Lymphoepithelioma of the Oropharynx; Stage III Mucoepidermoid Carcinoma of the Oral Cavity; Stage III Squamous Cell Carcinoma of the Hypopharynx; Stage III Squamous Cell Carcinoma of the Larynx; Stage

Internet Economics IV

Science.gov (United States)

2004-08-01

edts.): Internet Economics IV Technical Report No. 2004-04, August 2004 Information Systems Laboratory IIS, Departement of Computer Science University of...level agreements (SLA), Information technology (IT), Internet address, Internet service provider 16. PRICE CODE 17. SECURITY CLASSIFICATION 18... technology and its economic impacts in the Internet world today. The second talk addresses the area of AAA protocol, summarizing authentication

Flibe-D2 Permeation Experiment and Analysis

International Nuclear Information System (INIS)

Fukada, S.; Anderl, R.A.; Pawelko, R.J.; Smolik, G.R.; Schuetz, S.T.; O'Brien, J.E.; Nishimura, H.; Hatano, Y.; Terai, T.; Petti, D.A.; Sze, D.-K.; Tanaka, S.

2003-01-01

Experiment of D 2 permeation through Ni facing with purified Flibe is being carried out under the Japan-US joint research project (JUPITER-II). The experiment is proceeding in the following phases; (i) fabrication and assembly of a dual-probe permeation apparatus, (ii) a single-probe Ni/D 2 permeation experiment without Flibe, (iii) a dual-probe Ni/D 2 permeation experiment without Flibe, (iv) Flibe chemical purification by HF/H 2 gas bubbling, (v) physical purification by Flibe transport through a porous Ni filter, (vi) Ni/Flibe/D 2 permeation experiment, and (vii) Ni/Flibe/HT permeation experiment. The present paper describes results of the single and dual Ni/D 2 permeation experiments in detail

Upgrade for Phase II of the Gerda experiment

Science.gov (United States)

Agostini, M.; Bakalyarov, A. M.; Balata, M.; Barabanov, I.; Baudis, L.; Bauer, C.; Bellotti, E.; Belogurov, S.; Belyaev, S. T.; Benato, G.; Bettini, A.; Bezrukov, L.; Bode, T.; Borowicz, D.; Brudanin, V.; Brugnera, R.; Caldwell, A.; Cattadori, C.; Chernogorov, A.; D'Andrea, V.; Demidova, E. V.; Di Marco, N.; Domula, A.; Doroshkevich, E.; Egorov, V.; Falkenstein, R.; Frodyma, N.; Gangapshev, A.; Garfagnini, A.; Grabmayr, P.; Gurentsov, V.; Gusev, K.; Hakenmüller, J.; Hegai, A.; Heisel, M.; Hemmer, S.; Hiller, R.; Hofmann, W.; Hult, M.; Inzhechik, L. V.; Ioannucci, L.; Janicskó Csáthy, J.; Jochum, J.; Junker, M.; Kazalov, V.; Kermaïdic, Y.; Kihm, T.; Kirpichnikov, I. V.; Kirsch, A.; Kish, A.; Klimenko, A.; Kneißl, R.; Knöpfle, K. T.; Kochetov, O.; Kornoukhov, V. N.; Kuzminov, V. V.; Laubenstein, M.; Lazzaro, A.; Lebedev, V. I.; Lehnert, B.; Lindner, M.; Lippi, I.; Lubashevskiy, A.; Lubsandorzhiev, B.; Lutter, G.; Macolino, C.; Majorovits, B.; Maneschg, W.; Medinaceli, E.; Miloradovic, M.; Mingazheva, R.; Misiaszek, M.; Moseev, P.; Nemchenok, I.; Nisi, S.; Panas, K.; Pandola, L.; Pelczar, K.; Pullia, A.; Ransom, C.; Riboldi, S.; Rumyantseva, N.; Sada, C.; Salamida, F.; Salathe, M.; Schmitt, C.; Schneider, B.; Schönert, S.; Schreiner, J.; Schütz, A.-K.; Schulz, O.; Schwingenheuer, B.; Selivanenko, O.; Shevchik, E.; Shirchenko, M.; Simgen, H.; Smolnikov, A.; Stanco, L.; Vanhoefer, L.; Vasenko, A. A.; Veresnikova, A.; von Sturm, K.; Wagner, V.; Wegmann, A.; Wester, T.; Wiesinger, C.; Wojcik, M.; Yanovich, E.; Zhitnikov, I.; Zhukov, S. V.; Zinatulina, D.; Zsigmond, A. J.; Zuber, K.; Zuzel, G.

2018-05-01

The Gerda collaboration is performing a sensitive search for neutrinoless double beta decay of ^{76}Ge at the INFN Laboratori Nazionali del Gran Sasso, Italy. The upgrade of the Gerda experiment from Phase I to Phase II has been concluded in December 2015. The first Phase II data release shows that the goal to suppress the background by one order of magnitude compared to Phase I has been achieved. Gerda is thus the first experiment that will remain "background-free" up to its design exposure (100 kg year). It will reach thereby a half-life sensitivity of more than 10^{26} year within 3 years of data collection. This paper describes in detail the modifications and improvements of the experimental setup for Phase II and discusses the performance of individual detector components.

Separation of uranium(V I) from binary solution mixtures with thorium(IV), zirconium(IV) and cerium(III) by foaming

International Nuclear Information System (INIS)

Shakir, K.; Aziz, M.; Benyamin, K.

1992-01-01

Foam separation has been investigated for the removal of uranium(V I), thorium(IV), zirconium(IV) and cerium(III) from dilute aqueous solutions at pH values ranging from about I to about II. Sodium laurel sulphate (Na L S) and acetyl trimethyl ammonium bromide (CTAB), being a strong anionic and a strong cationic surfactants, were used as collectors. The results indicate that Na L S can efficiently remove thorium(IV), zirconium(IV) and cerium(III) but not uranium(V I). CTAB, on the other hand, can successfully float only uranium(V I) and zirconium(IV). These differences in flotation properties of the different cations could be used to establish methods for the separation of uranium(V I) from binary mixtures with thorium(IV), zirconium(IV) or cerium(III). The results are discussed in terms of the hydrolytic behaviour of the tested cations and properties of used collectors.2 fig., 1 tab

Optimising the use of marine tephrochronology in the North Atlantic: a detailed investigation of the Faroe Marine Ash Zones II, III and IV

Science.gov (United States)

Griggs, Adam J.; Davies, Siwan M.; Abbott, Peter M.; Rasmussen, Tine L.; Palmer, Adrian P.

2014-12-01

Tephrochronology is central to the INTIMATE goals for testing the degree of climatic synchroneity during abrupt climatic events that punctuated the last glacial period. Since their identification in North Atlantic marine sequences, the Faroe Marine Ash Zone II (FMAZ II), FMAZ III and FMAZ IV have received considerable attention due to their potential for high-precision synchronisation with the Greenland ice-cores. In order to optimise the use of these horizons as isochronous markers, a detailed re-investigation of their geochemical composition, sedimentology and the processes that deposited each ash zone is presented. Shard concentration profiles, geochemical homogeneity and micro-sedimentological structures are investigated for each ash zone preserved within core JM11-19PC, retrieved from the southeastern Norwegian Sea on the central North Faroe Slope. This approach allows a thorough assessment of primary ash-fall preservation and secondary depositional features and demonstrates its value for assessing depositional integrity in the marine environment. Results indicate that the FMAZ II and IV are well-resolved primary deposits that can be used as isochrons for high-precision correlation studies. We outline key recommendations for future marine tephra studies and provide a protocol for optimising the application of tephrochronology to meet the INTIMATE synchronisation goals.

Bone radioisotope scanning: usefulness in the evaluation and observation of patients with breast cancer in clinical stage II, III, IV

International Nuclear Information System (INIS)

Cano P, R.A.

1995-01-01

The clinical records of 420 patients with diagnosis of breast cancer well documented by the pathological anatomy in clinical stage II, III and IV were reviewed. In each one of them has been done at least a bone scanning during the diagnosis. In 52 cases carried out sericeous dosages of CA 15-3 and in some cases it was necessary to administer Samarium-153 EDTMP as palliative therapy of bone pain. The presence of secondary gamma-graphic focuses was 0/84 cases (0%) in clinical stage II, 54/265 cases (20%) in III and 41/91 cases (45%) in IV. The one focus appeared in 6.7% of the cases. In 7 of the 52 cases that received sericeous dosages of CA 15-3 were detected secondary osseous lesions, and 5 of them presented a marker elevation. The bone scanning has shown in many cases the presence of getters focuses in singular places of skeleton, urinary excretory system or mammary tissue. The gamma rays from Sm-153 allowed us to get some appropriate basal views post-therapy of the secondary lesions. The results show that the great incidence of secondary lesions in the skeleton occurred in cases of stages III and IV unlike other countries. The serial repetition of the radioisotope scanning. The presence of one focus in the skeleton of a patient with a well-known neoplasia makes us to do a careful evaluation of the focus nature. The presence of tracer accumulation in the kidney, ureter and bladder allows us to infer the pathology of excretory system that is the first evidence of its presence in many cases. (author). 71 refs., 7 figs., 6 tabs

Immobilization of 99-Technetium (VII) by Fe(II)-Goethite and Limited Reoxidation

Energy Technology Data Exchange (ETDEWEB)

W Um; H Chang; J Icenhower; W Lukens; R Serne; N Qafoku; J Westsik Jr.; E Buck; S Smith

2011-12-31

During the nuclear waste vitrification process volatilized {sup 99}Tc will be trapped by melter off-gas scrubbers and then washed out into caustic solutions, and plans are currently being contemplated for the disposal of such secondary waste. Solutions containing pertechnetate [{sup 99}Tc(VII)O{sub 4}{sup -}] were mixed with precipitating goethite and dissolved Fe(II) to determine if an iron (oxy)hydroxide-based waste form can reduce Tc(VII) and isolate Tc(IV) from oxygen. The results of these experiments demonstrate that Fe(II) with goethite efficiently catalyzes the reduction of technetium in deionized water and complex solutions that mimic the chemical composition of caustic waste scrubber media. Identification of the phases, goethite + magnetite, was performed using XRD, SEM and TEM methods. Analyses of the Tc-bearing solid products by XAFS indicate that all of the Tc(VII) was reduced to Tc(IV) and that the latter is incorporated into goethite or magnetite as octahedral Tc(IV). Batch dissolution experiments, conducted under ambient oxidizing conditions for more than 180 days, demonstrated a very limited release of Tc to solution (2-7 {micro}g Tc/g solid). Incorporation of Tc(IV) into the goethite lattice thus provides significant advantages for limiting reoxidation and curtailing release of Tc disposed in nuclear waste repositories.

DSM-V from the perspective of the DSM-IV experience.

Science.gov (United States)

Walsh, B Timothy

2007-11-01

This article provides a brief overview of the development of the diagnostic criteria for eating disorders in DSM-IV. The process by which DSM-IV was developed is reviewed, including perspectives on what constitutes diagnostic validity and clinical utility, and their importance in assessing proposed changes in diagnostic criteria. The question of whether alterations in diagnostic criteria would clearly improve clinical utility was a major consideration in the DSM-IV process. Because of concerns that changes in diagnostic criteria would be disruptive and might entail loss of established knowledge, the DSM-IV Task Force assumed a generally conservative stance vis-à-vis change. The process of developing DSM-V is just beginning, and it is far from clear what alterations in diagnostic criteria for eating disorders will occur. However, the evolution of DSM-IV may provide a useful perspective on the development of DSM-V. (c) 2007 by Wiley Periodicals, Inc.

Mapping the interaction site for the tarantula toxin hainantoxin-IV (β-TRTX-Hn2a) in the voltage sensor module of domain II of voltage-gated sodium channels.

Science.gov (United States)

Cai, Tianfu; Luo, Ji; Meng, Er; Ding, Jiuping; Liang, Songping; Wang, Sheng; Liu, Zhonghua

2015-06-01

Peptide toxins often have pharmacological applications and are powerful tools for investigating the structure-function relationships of voltage-gated sodium channels (VGSCs). Although a group of potential VGSC inhibitors have been reported from tarantula venoms, little is known about the mechanism of their interaction with VGSCs. In this study, we showed that hainantoxin-IV (β-TRTX-Hn2a, HNTX-IV in brief), a 35-residue peptide from Ornithoctonus hainana venom, preferentially inhibited rNav1.2, rNav1.3 and hNav1.7 compared with rNav1.4 and hNav1.5. hNav1.7 was the most sensitive to HNTX-IV (IC50∼21nM). In contrast to many other tarantula toxins that affect VGSCs, HNTX-IV at subsaturating concentrations did not alter activation and inactivation kinetics in the physiological range of voltages, while very large depolarization above +70mV could partially activate toxin-bound hNav1.7 channel, indicating that HNTX-IV acts as a gating modifier rather than a pore blocker. Site-directed mutagenesis indicated that the toxin bound to site 4, which was located on the extracellular S3-S4 linker of hNav1.7 domain II. Mutants E753Q, D816N and E818Q of hNav1.7 decreased toxin affinity for hNav1.7 by 2.0-, 3.3- and 130-fold, respectively. In silico docking indicated that a three-toed claw substructure formed by residues with close contacts in the interface between HNTX-IV and hNav1.7 domain II stabilized the toxin-channel complex, impeding movement of the domain II voltage sensor and inhibiting hNav1.7 activation. Our data provide structural details for structure-based drug design and a useful template for the design of highly selective inhibitors of a specific subtype of VGSCs. Copyright © 2014 Elsevier Inc. All rights reserved.

Adaptation of U(IV) reductant to Savannah River Plant Purex processes

International Nuclear Information System (INIS)

Orebaugh, E.G.

1986-04-01

Partitioning of uranium and plutonium in the Purex process requires the reduction of the extracted Pu(IV) to the less extractable Pu(III). This valence adjustment at SRP has historically been performed by the addition of ferrous ion, which eventually constitutes a major component of high-level waste solids requiring costly permanent disposal. Uranous nitrate, U(IV), is a kinetically fast reductant which may be substituted for Fe(II) without contributing to waste solids. This report documents U(IV) flowsheet development in the miniature mixer-settler equipment at SRL and provides an insight into the mechanisms responsible for the successful direct substitution of U(IV) for Fe(II) in 1B bank extractant. U(IV) will be the reductant of choice when its fast reduction kinetics are required in centrifugal-contactor-based processing. The flowsheets investigated here should transfer to such equipment with minimal modifications

Experiments on ferrimagnetism

International Nuclear Information System (INIS)

Kraftmakher, Yaakov

2013-01-01

Ferrimagnetism undoubtedly deserves a proper place in the undergraduate laboratory on electricity and magnetism. Four student experiments on ferrimagnetism are considered: (i) the hysteresis loops and permeability of a ‘soft’ ferrite; (ii) the differential permeability versus a dc bias; (iii) the frequency dependence of the complex permeability and (iv) the electromagnetic interference suppression by ferrite chokes and beads. Two ferrite cores taken off a low-frequency choke and a power cord are used. The measurements are simple and straightforward and show the important properties of ferrites and their applications. The values of the permeability of the ferrite core determined in experiments (i)–(iii) are in reasonable agreement. The frequency dependence of the complex permeability of the ferrites is similar to that given by the manufacturers. The capability of absorbing electromagnetic waves in a definite frequency range shown in experiment (iv) demonstrates one of the principles of Stealth technology. The equipment necessary for the experiments can be found in many student laboratories. (paper)

Phase II trial of the regulatory T cell-depleting agent, denileukin diftitox, in patients with unresectable stage IV melanoma

International Nuclear Information System (INIS)

Telang, Sucheta; Gragg, Hana; Clem, Brian F; McMasters, Kelly M; Miller, Donald M; Chesney, Jason; Rasku, Mary Ann; Clem, Amy L; Carter, Karen; Klarer, Alden C; Badger, Wesley R; Milam, Rebecca A; Rai, Shesh N; Pan, Jianmin

2011-01-01

We previously found that administration of an interleukin 2/diphtheria toxin conjugate (DAB/IL2; Denileukin Diftitox; ONTAK) to stage IV melanoma patients depleted CD4 + CD25 HI Foxp3 + regulatory T cells and expanded melanoma-specific CD8 + T cells. The goal of this study was to assess the clinical efficacy of DAB/IL2 in an expanded cohort of stage IV melanoma patients. In a single-center, phase II trial, DAB/IL2 (12 μg/kg; 4 daily doses; 21 day cycles) was administered to 60 unresectable stage IV melanoma patients and response rates were assessed using a combination of 2-[ 18 F]-fluoro-2-deoxy-glucose (FDG)-positron emission tomography (PET) and computed tomography (CT) imaging. After DAB/IL2 administration, 16.7% of the 60 patients had partial responses, 5% stable disease and 15% mixed responses. Importantly, 45.5% of the chemo/immuno-naïve sub-population (11/60 patients) experienced partial responses. One year survival was markedly higher in partial responders (80 ± 11.9%) relative to patients with progressive disease (23.7 ± 6.5%; p value < 0.001) and 40 ± 6.2% of the total DAB/IL2-treated population were alive at 1 year. These data support the development of multi-center, randomized trials of DAB/IL2 as a monotherapy and in combination with other immunotherapeutic agents for the treatment of stage IV melanoma. http://www.clinicaltrials.gov/ct2/show/NCT00299689

Occurrences of flares with type II and IV radio events in interacting sunspot groups in the course of revolutions

International Nuclear Information System (INIS)

Klimes, J.; Krivsky, L.

1984-01-01

Using data from 11-year solar cycle No. 20, it was found that flares with type II radio bursts are more than twice as frequent and flares with type IV bursts nearly twice as frequent in sunspot groups which developed close to each other or which merged in the course of revolutions than in isolated sunspot groups. With both types the occurrence of these flares is concentrated in the revolution of the so-called sunspot group interaction (their approximation, merging). (author)

75 FR 23263 - Alta Wind I, LLC; Alta Wind II, LLC; Alta Wind III, LLC; Alta Wind IV, LLC; Alta Wind V, LLC...

Science.gov (United States)

2010-05-03

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. EL10-62-000] Alta Wind I, LLC; Alta Wind II, LLC; Alta Wind III, LLC; Alta Wind IV, LLC; Alta Wind V, LLC; Alta Wind VI, LLC; Alta Wind VII, LLC; Alta Wind VIII, LLC; Alta Windpower Development, LLC; TGP Development Company, LLC...

Effect of anthropogenic organic complexants on the solubility of Ni, Th, U(IV) and U(VI)

Energy Technology Data Exchange (ETDEWEB)

Felipe-Sotelo, M., E-mail: m.felipe-sotelo@lboro.ac.uk [Department of Chemistry, Loughborough University, LE11 3TU Loughborough, Leicestershire (United Kingdom); Edgar, M. [Department of Chemistry, Loughborough University, LE11 3TU Loughborough, Leicestershire (United Kingdom); Beattie, T. [MCM Consulting. Täfernstrasse 11, CH 5405 Baden-Dättwil (Switzerland); Warwick, P. [Enviras Ltd., LE11 3TU Loughborough, Leicestershire (United Kingdom); Evans, N.D.M.; Read, D. [Department of Chemistry, Loughborough University, LE11 3TU Loughborough, Leicestershire (United Kingdom)

2015-12-30

Highlights: • Citrate increases the solubility of Ni, Th and U between 3 and 4 orders of magnitude. • Theophrastite is the solubility controlling phase of Ni in 95%-saturated Ca(OH){sub 2}. • U(VI) and Ni may form Metal-citrate-OH complexes stabilised by the presence of Ca{sup 2+}. - Abstract: The influence of anthropogenic organic complexants (citrate, EDTA and DTPA from 0.005 to 0.1 M) on the solubility of nickel(II), thorium(IV) and uranium (U(IV) and U(VI)) has been studied. Experiments were carried out in 95%-saturated Ca(OH){sub 2} solutions, representing the high pH conditions anticipated in the near field of a cementitious intermediate level radioactive waste repository. Results showed that Ni(II) solubility increased by 2–4 orders of magnitude in the presence of EDTA and DTPA and from 3 to 4 orders of magnitude in the case of citrate. Citrate had the greatest effect on the solubility of Th(IV) and U(IV)/(VI). XRD and SEM analyses indicate that the precipitates are largely amorphous; only in the case of Ni(II), is there some evidence of incipient crystallinity, in the form of Ni(OH){sub 2} (theophrastite). A study of the effect of calcium suggests that U(VI) and Ni(II) may form metal-citrate-OH complexes stabilised by Ca{sup 2+}. Thermodynamic modelling underestimates the concentrations in solution in the presence of the ligands for all the elements considered here. Further investigation of the behaviour of organic ligands under hyperalkaline conditions is important because of the use of the thermodynamic constants in preparing the safety case for the geological disposal of radioactive wastes.

Are stage IV vestibular schwannomas preoperatively different from other stages?

Science.gov (United States)

Tringali, Stéphane; Dubreuil, Christian; Zaouche, Sandra; Ferber-Viart, Chantal

2008-01-01

The aim of this study was to focus on the clinical and paraclinical symptoms of patients suffering from Stage IV vestibular schwannomas (VSs). In this prospective study, we included 734 patients who have VS and candidates for operation. Patients were classified as having Stage I, II, III, or IV tumors according to Tos criteria as evaluated by magnetic resonance imaging. PREOPERATIVE CLINICAL EVALUATION: We recorded the occurrence of complaints (%) and duration (yr) of hearing loss, tinnitus, and balance disorder. Preoperative paraclinical evaluation included pure-tone (PTA) and speech audiometry, auditory brainstem response (ABR) patterns, and vestibular deficit at videonystamography (VNG). Continuous variables were compared between Stage IV and other stages using analysis of variance. Qualitative variables expressed as a percentage of presence were compared between Stage IV and other stages using percentage comparison. Quantitative Parameters. Patients with Stage IV VS were significantly younger as compared with patients with other stages. Stage IV hearing loss was greater compared with other stages at 250 and 500 Hz but smaller at 2,000 and 8,000 Hz. We found no difference in the loss of PTA between Stage IV and the other stages. Speech discriminancy score was smaller in Stage IV. The durations of hearing loss, tinnitus, and balance disorders were similar whatever the tumor stage. Auditory brainstem response patterns showed no difference in Wave III latency between Stage IV VS and other stages, whereas Wave V latency and V-I interval were higher in Stage IV. Both ABR threshold and VNG caloric deficit were higher in Stage IV VS compared with other stages. Qualitative Parameters. The percentage of patients with Stage IV was lower than that with Stages II and III. The percentage of men and women was similar in all stages. The occurrence of hearing loss was similar in all stages, whereas that of tinnitus was lower in Stage IV compared with Stages I and II. In

Concordance of DSM-IV Axis I and II diagnoses by personal and informant's interview.

Science.gov (United States)

Schneider, Barbara; Maurer, Konrad; Sargk, Dieter; Heiskel, Harald; Weber, Bernhard; Frölich, Lutz; Georgi, Klaus; Fritze, Jürgen; Seidler, Andreas

2004-06-30

The validity and reliability of using psychological autopsies to diagnose a psychiatric disorder is a critical issue. Therefore, interrater and test-retest reliability of the Structured Clinical Interview for DSM-IV Axis I and Personality Disorders and the usefulness of these instruments for the psychological autopsy method were investigated. Diagnoses by informant's interview were compared with diagnoses generated by a personal interview of 35 persons. Interrater reliability and test-retest reliability were assessed in 33 and 29 persons, respectively. Chi-square analysis, kappa and intraclass correlation coefficients, and Kendall's tau were used to determine agreement of diagnoses. Kappa coefficients were above 0.84 for substance-related disorders, mood disorders, and anxiety and adjustment disorders, and above 0.65 for Axis II disorders for interrater and test-retest reliability. Agreement by personal and relative's interview generated kappa coefficients above 0.79 for most Axis I and above 0.65 for most personality disorder diagnoses; Kendall's tau for dimensional individual personality disorder scores ranged from 0.22 to 0.72. Despite of a small number of psychiatric disorders in the selected population, the present results provide support for the validity of most diagnoses obtained through the best-estimate method using the Structured Clinical Interview for DSM-IV Axis I and Personality Disorders. This instrument can be recommended as a tool for the psychological autopsy procedure in post-mortem research. Copyright 2004 Elsevier Ireland Ltd.

Status of the Gerda phase II experiment

Energy Technology Data Exchange (ETDEWEB)

Lazzaro, Andrea [Physik-Department and Excellence Cluster Universe, Technische Universitaet Muenchen (Germany); Collaboration: GERDA-Collaboration

2016-07-01

The Gerda experiment searches for the neutrinoless double beta decay (0νββ) in {sup 76}Ge. The first phase of the experiment collected 21.6 kg. yr of exposure with a background index (BI) of 0.01 cts/(keV . kg . yr). No signal was observed and a lower limit for the 0νββ half-life was set to T{sup 0νββ}{sub 1/2} < 2.1 . 10{sup 25} yr (90% C.L). The apparatus has now been upgraded to the Phase II configuration. In Phase II 38 kg of HPGe detectors will be operated to reach an exposure of 100 kg . yr. The goal of Gerda Phase II is to lower the BI to 10{sup -3} cts/(keV . kg . y), in order to reach the sensitivity for T{sup 0νββ}{sub 1/2} = O(10{sup 26}) yr. The additional target mass is constituted of 30 custom made BEGe detectors with higher energy resolution and better pulse shape discrimination performance. The detectors are operated in new radio-pure low-mass holders. The liquid argon surrounding the detectors has been instrumented to veto the background events which produce scintillation light. In this talk the current status and the performance of the Gerda Phase II are presented.

Diagnostic Efficiency among Psychiatric Outpatients of a Self-Report Version of a Subset of Screen Items of the Structured Clinical Interview for DSM-IV-TR Personality Disorders (SCID-II)

Science.gov (United States)

Germans, Sara; Van Heck, Guus L.; Masthoff, Erik D.; Trompenaars, Fons J. W. M.; Hodiamont, Paul P. G.

2010-01-01

This article describes the identification of a 10-item set of the Structured Clinical Interview for DSM-IV Personality Disorders (SCID-II) items, which proved to be effective as a self-report assessment instrument in screening personality disorders. The item selection was based on the retrospective analyses of 495 SCID-II interviews. The…

Report for 2011 from the Bordeaux IVS Analysis Center

Science.gov (United States)

Charlot, Patrick; Bellanger, Antoine; Bourda, Geraldine; Collioud, Arnaud; Baudry, Alain

2012-01-01

This report summarizes the activities of the Bordeaux IVS Analysis Center during the year 2011. The work focused on (i) regular analysis of the IVS-R1 and IVS-R4 sessions with the GINS software package; (ii) systematic VLBI imaging of the RDV sessions and calculation of the corresponding source structure index and compactness values; (iii) imaging of the sources observed during the 2009 International Year of Astronomy IVS observing session; and (iv) continuation of our VLBI observational program to identify optically-bright radio sources suitable for the link with the future Gaia frame. Also of importance is the enhancement of the IVS LiveWeb site which now comprises all IVS sessions back to 2003, allowing one to search past observations for session-specific information (e.g. sources or stations).

II-VI semiconductor compounds

CERN Document Server

1993-01-01

For condensed matter physicists and electronic engineers, this volume deals with aspects of II-VI semiconductor compounds. Areas covered include devices and applications of II-VI compounds; Co-based II-IV semi-magnetic semiconductors; and electronic structure of strained II-VI superlattices.

Te(II)/Te(IV) Mediated C-N Bond Formation on 2,5-Diphenyltellurophene and a Reassignment of the Product from the Reaction of PhI(OAc)2 with 2 TMS-OTf.

Science.gov (United States)

Aprile, Antonino; Iversen, Kalon J; Wilson, David J D; Dutton, Jason L

2015-05-18

We report a novel C-H to C-N bond metathesis at the 3-position of 1,2-diphenyltellurophene via oxidation of the Te(II) center to Te(IV) using the I(III) oxidant [PhI(4-DMAP)2](2+). Spontaneous reduction of a transient Te(IV) coordination compound to Te(II) generates an electrophilic equivalent of 4-DMAP that substitutes at a C-H bond at the 3-position of the tellurophene. Theoretical and synthetic reaction pathway studies confirm that a Te(IV) coordination complex with 4-DMAP is an intermediate. In the course of these pathway studies, it was also found that the identity of the I(III) oxidant generated from PhI(OAc)2 and 2 TMS-OTf is PhI(OAc)(OTf) and not PhI(OTf)2, as had been previously thought.

Training experience at Experimental Breeder Reactor II

International Nuclear Information System (INIS)

Driscoll, J.W.; McCormick, R.P.; McCreery, H.I.

1978-01-01

The EBR-II Training Group develops, maintains,and oversees training programs and activities associated with the EBR-II Project. The group originally spent all its time on EBR-II plant-operations training, but has gradually spread its work into other areas. These other areas of training now include mechanical maintenance, fuel manufacturing facility, instrumentation and control, fissile fuel handling, and emergency activities. This report describes each of the programs and gives a statistical breakdown of the time spent by the Training Group for each program. The major training programs for the EBR-II Project are presented by multimedia methods at a pace controlled by the student. The Training Group has much experience in the use of audio-visual techniques and equipment, including video-tapes, 35 mm slides, Super 8 and 16 mm film, models, and filmstrips. The effectiveness of these techniques is evaluated in this report

Global track finder for Belle II experiment

Energy Technology Data Exchange (ETDEWEB)

Trusov, Viktor; Feindt, Michael; Heck, Martin; Kuhr, Thomas; Goldenzweig, Pablo [Karlsruhe Institute of Technology, IEKP (Germany); Collaboration: Belle II-Collaboration

2015-07-01

We present an implementation of a method based on the Legendre transformation for reconstruction charged particle tracks in the central drift chamber of the Belle II experiment. The method is designed for fast track finding and restoring circular patterns of track hits in transverse plane. It is done by searching for common tangents to drift circles of hits in the conformal space. With known transverse trajectories longitudinal momentum estimation performed by assigning stereo hits followed by determination of the track parameters. The method includes algorithms responsible for track quality estimation and reduction of rate of fakes. The work is targeting at increasing the efficiency and reducing the execution time because the computing power available to the experiment is limited. The algorithm is developed within the Belle II software environment with using Monte-Carlo simulation for probing its efficiency.

Development of reliable analytical method for extraction and separation of thorium(IV) by Cyanex 272 in kerosene

International Nuclear Information System (INIS)

Madane, N.S.; Mohite, B.S.

2011-01-01

A simple and selective spectrophotometric method has been developed for the extraction and separation of thorium(IV) from sodium salicylate media using Cyanex 272 in kerosene. Thorium(IV) was quantitatively extracted by 5 x 10 -4 M Cyanex 272 in kerosene from 1 x 10 -5 M sodium salicylate medium. The extracted thorium(IV) was stripped out quantitatively from the organic phase with 4.0 M hydrochloric acid and determined spectrophotometrically with arsenazo(III) at 620 nm. The effect of concentrations of sodium salicylate, extractant, diluents, metal ion and strippants has been studied. Separation of thorium(IV) from other elements was achieved from binary as well as multicomponent mixtures such as uranium(VI), strontium(II), rubidium(I), cesium(I), potassium(I), Sodium(I), lithium(I), lead(II), barium(II), beryllium(II) etc. Using this method separation and determination of thorium(IV) in geological and real samples has been carried out. The method is simple, rapid and selective with good reproducibility (approximately ±2%). (author)

Determination of plutonium in nitric acid solutions - Method by oxidation by cerium(IV), reduction by iron(II) ammonium sulfate and amperometric back-titration with potassium dichromate

International Nuclear Information System (INIS)

1987-01-01

This International Standard specifies a precise and accurate analytical method for determining plutonium in nitric acid solutions. Plutonium is oxidized to plutonium(VI) in a 1 mol/l nitric acid solution with cerium(IV). Addition of sulfamic acid prevents nitrite-induced side reactions. The excess of cerium(IV) is reduced by adding a sodium arsenite solution, catalysed by osmium tetroxide. A slight excess of arsenite is oxidized by adding a 0.2 mol/l potassium permanganate solution. The excess of permanganate is reduced by adding a 0.1 mol/l oxalic acid solution. Iron(III) is used to catalyse the reduction. A small excess of oxalic acid does not interfere in the subsequent plutonium determination. These reduction and oxidation stages can be followed amperometrically and the plutonium is left in the hexavalent state. The sulfuric acid followed by a measured amount of standardized iron(II) ammonium sulfate solution in excess of that required to reduce the plutonium(VI) to plutonium(IV) is added. The excess iron(II) and any plutonium(III) formed to produce iron(III) and plutonium(IV) is amperometrically back-titrated using a standard potassium dichromate solution. The method is almost specifically for plutonium. It is suitable for the direct determination of plutonium in materials ranging from pure product solutions, to fast reactor fuel solutions with a uranium/plutonium ratio of up to 10:1, either before or after irradiation

Accentuated hyperparathyroidism in type II Bartter syndrome.

Science.gov (United States)

Landau, Daniel; Gurevich, Evgenia; Sinai-Treiman, Levana; Shalev, Hannah

2016-07-01

Bartter syndrome (BS) may be associated with different degrees of hypercalciuria, but marked parathyroid hormone (PTH) abnormalities have not been described. We compared clinical and laboratory data of patients with either ROMK-deficient type II BS (n = 14) or Barttin-deficient type IV BS (n = 20). Only BS-IV patients remained mildly hypokalemic in spite of a higher need for potassium supplementation. Estimated glomerular filtration rate (eGFR) was mildly decreased in only four BS-IV patients. Average PTH values were significantly higher in BS-II (160.6 ± 85.8 vs. 92.5 ± 48 pg/ml in BS-IV, p = 0.006). In both groups, there was a positive correlation between age and log(PTH). Levels of 25(OH) vitamin D were not different. Total serum calcium was lower (within normal limits) and age-related serum phosphate (Pi)-SDS was increased in BS-II (1.19 ± 0.71 vs. 0.01 ± 1.04 in BS-IV, p < 0.001). The GFR threshold for Pi reabsorption was higher in BS-II (5.63 ± 1.25 vs. 4.36 ± 0.98, p = 0.002). Spot urine calcium/creatinine ratio and nephrocalcinosis rate (100 vs. 16 %) were higher in the BS-II group. PTH, serum Pi levels, and urinary threshold for Pi reabsorption are significantly elevated in type II vs. type IV BS, suggesting a PTH resistance state. This may be a response to more severe long-standing hypercalciuria, leading to a higher rate of nephrocalcinosis in BS-II.

Angiotensin IV possibly acts through PKMzeta in the hippocampus to regulate cognitive memory in rats.

Science.gov (United States)

Chow, Lok-Hi; Tao, Pao-Luh; Chen, Yuan-Hao; Lin, Yu-Hui; Huang, Eagle Yi-Kung

2015-10-01

Ang IV is an endogenous peptide generated from the degradation of angiotensin II. Ang IV was found to enhance learning and memory in CNS. PKMzeta was identified to be a fragment of PKCzeta (protein kinase Czeta). Its continuous activation was demonstrated to be correlated with the formation of memory in the hippocampus. Therefore, we investigated whether PKMzeta participates in the effects of Ang IV on memory. We first examined the effect of Ang IV on non-spatial memory/cognition in modified object recognition test in rats. Our data showed that Ang IV could increase the exploration time on novel object. The co-administration of ZIP (PKMzeta inhibitor) with Ang IV significantly blocked the effect by Ang IV. The effects of Ang IV on hippocampal LTP at the CA1 region were also evaluated. Ang IV significantly increased the amplitude and slope of the EPSPs, which was consistent with other reports. Surprisingly, instead of potentiating LTP, Ang IV caused a failed maintenance of LTP. Moreover, there was no quantitative change in PKMzeta induced by Ang IV and/or ZIP after behavioral experiments. Taken together, our data re-confirmed the finding of the positive effect of Ang IV to enhance memory/cognition. The increased strength of EPSPs with Ang IV could also have certain functional relevance. Since the behavioral results suggested the involvement of PKMzeta, we hypothesized that the enhancement of memory/cognition by Ang IV may rely on an increase in PKMzeta activity. Overall, the present study provided important advances in our understanding of the action of Ang IV in the hippocampus. Copyright © 2015 Elsevier Ltd. All rights reserved.

Perturbative Heat Transport Experiments on TJ-II

International Nuclear Information System (INIS)

Eguilor, S.; Castejon, F.; Luna, E. de la; Cappa, A.; Likin, K.; Fernandez, A.; Tj-II, T.

2002-01-01

Heat wave experiments are performed on TJ-II stellarator plasmas to estimate both heat diffusivity and power deposition profiles. High frequency ECRH modulation experiments are used to obtain the power deposition profiles, which is observed to be wider and duller than estimated by tracing techniques. The causes of this difference are discussed in the paper. Fourier analysis techniques are used to estimate the heat diffusivity in low frequency ECRH modulation experiments. This include the power deposition profile as a new ingredient. ECHR switch on/off experiments are exploited to obtain power deposition and heat diffusivities profile. Those quantities are compared with the obtained by modulation experiments and transport analysis, showing a good agreement. (Author) 18 refs

Perturbative Heat Transport Experiments on TJ-II

Energy Technology Data Exchange (ETDEWEB)

Eguilor, S.; Castejon, F.; Luna, E. de la; Cappa, A.; Likin, K.; Fernandez, A.; Tj-II, T.

2002-07-01

Heat wave experiments are performed on TJ-II stellarator plasmas to estimate both heat diffusivity and power deposition profiles. High frequency ECRH modulation experiments are used to obtain the power deposition profiles, which is observed to be wider and duller than estimated by tracing techniques. The causes of this difference are discussed in the paper. Fourier analysis techniques are used to estimate the heat diffusivity in low frequency ECRH modulation experiments. This include the power deposition profile as a new ingredient. ECHR switch on/off experiments are exploited to obtain power deposition and heat diffusivities profile. Those quantities are compared with the obtained by modulation experiments and transport analysis, showing a good agreement. (Author) 18 refs.

Description of nighttime cough epochs in patients with stable COPD GOLD II-IV.

Science.gov (United States)

Fischer, Patrick; Gross, Volker; Kroenig, Johannes; Weissflog, Andreas; Hildebrandt, Olaf; Sohrabi, Keywan; Koehler, Ulrich

Chronic cough is one of the main symptoms of COPD. Ambulatory objective monitoring provides novel insights into the determinants and characteristics of nighttime cough in COPD. Nighttime cough was monitored objectively by LEOSound lung sound monitor in patients with stable COPD II-IV. In 30 patients, with 10 patients in each stage group, nighttime cough was analyzed for epoch frequency, epoch severity (epoch length and coughs per epoch), and pattern (productive or nonproductive). Cough was found in all patients ranging from 1 to 294 events over the recording period. In 29 patients, cough epochs were monitored, ranging from 1 to 75 epochs. The highest amount of cough epochs was found in patients with COPD stage III. Active smokers had significantly more productive cough epochs (61%) than nonsmokers (24%). We found a high rate of nighttime cough epochs in patients with COPD, especially in those in stage III. Productive cough was predominantly found in patients with persistent smoking. LEOSound lung sound monitor offers a practical and valuable opportunity to evaluate cough objectively.

RADLAC II high current electron beam propagation experiment

International Nuclear Information System (INIS)

Frost, C.A.; Shope, S.L.; Mazarakis, M.G.; Poukey, J.W.; Wagner, J.S.; Turman, B.N.; Crist, C.E.; Welch, D.R.; Struve, K.W.

1993-01-01

The resistive hose instability of an electron beam was observed to be convective in recent RADLAC II experiments for higher current shots. The effects of air scattering for these shots were minimal. These experiments and theory suggest low-frequency hose motion which does not appear convective may be due to rapid expansion and subsequent drifting of the beam nose

SPQR II: A beam-plasma interaction experiment

International Nuclear Information System (INIS)

Bimbot, R.; Della-Negra, S.; Gardes, D.

1986-01-01

SPQR II is an interaction experiment designed to probe energy -and charge-exchange of C/sup n/ + ions at 2 MeV/a.m.u., flowing through a fully ionized plasma column of hydrogen with nl-script = 10 19 e-cm -2 at T = 5 eV

Atlas of fine structures of dynamic spectra of solar type IV-dm and some type II radio bursts

International Nuclear Information System (INIS)

Slottje, C.

1982-01-01

The author presents an atlas of spectral fine structures of solar radio bursts of types IV and II around 1 m wavelength, as obtained with a multichannel spectrograph at Dwingeloo. The structures form largely a collection of observations of these events during late 1968 through 1974, thus covering almost entirely the declining branch of solar cycle 20. The spectrograph has an extra enhanced contrast output with properties quite different from those of the commonly used swept frequency spectrographs. The corresponding instrumental characteristics and effects are discussed. A classification of fine structures and an analysis of their statistical properties and of those of the pertinent radio events are also given. (Auth.)

First results of the Auroral Turbulance II rocket experiment

DEFF Research Database (Denmark)

Danielides, M.A.; Ranta, A.; Ivchenco, N.

1999-01-01

The Auroral Turbulance II sounding rocket was launched on February 11, 1997 into moderately active nightside aurora from the Poker Flat Research Range, Alaska, US. The experiment consisted of three independent, completely instrumented payloads launched by a single vehicle. The aim of the experiment...

Coordination Nature of 4-Mercaptoaniline to Sn(II Ion: Formation of a One Dimensional Coordination Polymer and Its Decomposition to a Mono Nuclear Sn(IV Complex

Directory of Open Access Journals (Sweden)

Eon S. Burkett

2014-12-01

Full Text Available The coordination of the bifunctional ligand 4-mercaptoaniline with aqueo us tin(II metal ion was studied. A coordination polymer was synthesized when an aqueous solution of SnCl2 was treated with 4-MA. The crystalline material is stable under atmospheric conditions retaining its oxidation state. However, when submerged in a solution saturated with oxygen, the compound oxidizes to a mononuclear tin(IV complex. Both the compounds were characterized by single crystal X-ray diffraction studies. Although the structure of the tin(IV complex was previously reported, crystal structure of this compound was redetermined.

Experimental determination of the energy levels of the antimony atom (Sb II), ions of the antimony (Sb II, Sb III), mercury (Hg IV) and cesium (Cs X)

International Nuclear Information System (INIS)

Arcimowicz, B.

1993-01-01

The thesis concerns establishing the energy scheme of the electronic levels, obtained from the analysis of the investigated spectra of antimony atom and ions (Sb I, Sb II, Sb III) and higher ionized mercury (Hg IV) and cesium (Cs X) atoms. The experimental studies were performed with optical spectroscopy methods. The spectra of the elements under study obtained in the spectral range from visible (680 nm) to vacuum UV (40 nm) were analysed. The classification and spectroscopic designation of the experimentally established 169 energy levels were obtained on the basis of the performed calculations and the fine structure analysis. The following configurations were considered: 5s 2 5p 2 ns, 5s 2 5p 2 n'd, 5s5p 4 of the antimony atom, 5s 2 5pns, 5s 2 5pn'd, 5s5p 3 of the ion Sb II, 5s 2 ns, 5s 2 n'd, 5s5p 2 of the on Sb III, 5d 8 6p of the ion Hg IV 4d 9 5s and 4d 9 5p Cs X. A reclassification was performed and some changes were introduced to the existing energy level scheme of the antimony atom, with the use of the information obtained from the absorption spectrum taken in the VUV region by the ''flash pyrolysis'' technique. The measurements of the hyperfine splittings in 19 spectral lines belonging to the antimony atom and ions additionally confirmed the assumed classification of the levels involved in these lines. The energy level scheme, obtained for Sb III, was compared to the other ones in the isoelectronic sequence starting with In I. On the basis of the analysis of the Hg IV spectrum it was proved that ground configuration of the three times ionized mercury atom is 5d 9 not 5d 8 6s as assumed until now. The fine structure, established from the analysis of the spectra of the elements under study was examined in multiconfiguration approximation. As a result of the performed calculations the fine structure parameters and wavefunctions were determined for the levels whose energy values were experimentally established in the thesis. (author). 140 refs, 22 figs, 17

Determination of uranium (IV) by flow voltammetry

International Nuclear Information System (INIS)

Ding Anqing

1987-01-01

According to the quantitative reaction of U(IV) and Fe(III) in H 2 SO 4 as well as the relation between current and concentration of substance detected, U(IV) has been determined indirectly by measurement of the electrolysis current of residual Fe(III). The columniform electrode used is made of glass carbon particles. At the range of U(IV) from a few micrograms to 40 μg, the linear relation is excellent. The relative standard deviation is within ±4%. The interference of Fe(II), Ti(IV) and U(VI) is negligible but of Ti(III) is serious. This method has been successfully applied in the determination of actual samples (both out line and on line). Main advantages of this procedure are rapid, simple, small amount of sample (only at microgram level) and easy to realize automation, able to use for on line or process analysis

Operational Experience from LCLS-II Cryomodule Testing

Energy Technology Data Exchange (ETDEWEB)

Wang, Renzhuo [Fermilab; Hansen, Benjamin [Fermilab; White, Michael [Fermilab; Hurd, Joseph [Fermilab; Atassi, Omar Al [Fermilab; Bossert, Richard [Fermilab; Pei, Liujin [Fermilab; Klebaner, Arkadiy [Fermilab; Makara, Jerry [Fermilab; Theilacker, Jay [Fermilab; Kaluzny, Joshua [Fermilab; Wu, Genfa [Fermilab; Harms, Elvin [Fermilab

2017-07-01

This paper describes the initial operational experience gained from testing Linac Coherent Light Source II (LCLS-II) cryomodules at Fermilab’s Cryomodule Test Facility (CMTF). Strategies for a controlled slow cooldown to 100 K and a fast cooldown past the niobium superconducting transition temperature of 9.2 K will be described. The test stand for the cryomodules at CMTF is sloped to match gradient in the LCLS-II tunnel at Stanford Linear Accelerator (SLAC) laboratory, which adds an additional challenge to stable liquid level control. Control valve regulation, Superconducting Radio-Frequency (SRF) power compensation, and other methods of stabilizing liquid level and pressure in the cryomodule 2.0 K SRF cavity circuit will be discussed. Several different pumping configurations using cold compressors and warm vacuum pumps have been used on the cryomodule 2.0 K return line and the associated results will be described.

Operational experience from LCLS-II cryomodule testing

Science.gov (United States)

Wang, R.; Hansen, B.; White, M.; Hurd, J.; Atassi, O. Al; Bossert, R.; Pei, L.; Klebaner, A.; Makara, J.; Theilacker, J.; Kaluzny, J.; Wu, G.; Harms, E.

2017-12-01

This paper describes the initial operational experience gained from testing Linac Coherent Light Source II (LCLS-II) cryomodules at Fermilab’s Cryomodule Test Facility (CMTF). Strategies for a controlled slow cooldown to 100 K and a fast cooldown past the niobium superconducting transition temperature of 9.2 K will be described. The test stand for the cryomodules at CMTF is sloped to match gradient in the LCLS-II tunnel at Stanford Linear Accelerator (SLAC) laboratory, which adds an additional challenge to stable liquid level control. Control valve regulation, Superconducting Radio-Frequency (SRF) power compensation, and other methods of stabilizing liquid level and pressure in the cryomodule 2.0 K SRF cavity circuit will be discussed. Several different pumping configurations using cold compressors and warm vacuum pumps have been used on the cryomodule 2.0 K return line and the associated results will be described.

Crystal structure of ammonium octacyanomolybdate(IV) and rubidium octacyanomolybdate(IV)

Energy Technology Data Exchange (ETDEWEB)

Semenishin, D.I.; Glovyak, T.; Mys' kiv, M.G.

1985-11-01

The crystal structure of ammonium octacyanomolybdate(IV) and rubidium octacyanomolybdate(IV) has been determined by the single-crystal method on a Syntex P2/sub 1/ automatic diffractometer: ((NH/sub 4/)/sub 4/ Mo(CN)/sub 4/) 0.5H/sub 2/O (I) (space group Pma2, a = 15.550(3), b = 14.118(3), c = 7.438(1) A, Z = 4, R = 0.062) and Rb/sub 4/(Mo(CN)/sub 8/). 3H/sub 2/O (II) (space group P4/sub 1/2/sub 1/2, a = 9.300(10, c = 21.807(3) A, Z = 4, R = 0.065). The Mo atoms in structure I occupy two special positions (2(b) and 2(c)) and are each surrounded by eight CN ligands. The mean value of the Mo-C distances for Mo(1) is equal to 2.216 A, and the corresponding value for Mo(2) is 2.235 A. The mean Mo-N lengths are practically identical in both molybdenum anions and are equal to 3.353 A. The mean values of the C identical with N bond lengths in the Mo(1) and Mo(2) anions are 1.118 and 1.137 A, respectively. The MoCn angles vary from 175.0 to 178.4/sup 0/. The coordination sphere of the Mo(1) atom corresponds to a dodecahedron with a single twofold symmetry axis, and the coordination polyhedron of the Mo(2) atom in an antiprism of m symmetry. In structure II the Mo-C distances are within the 2.130-2.160-A range, and the Mo-N distances range from 3.290 to 3.307 A. The MoCN angles vary from 176.0 to 179.3/sup 0/, and the coordination polyhedron of (MoC/sub 8/) is a dodecahedron of 2 symmetry. The existence of two types of coordination of Mo in structure I is presently the only example among the structurally studied octahyanomolybdates(IV).

Sulphonated metal phthalocyanine complexes as redox indicators in micro titrations with cerium(IV) sulphate

Energy Technology Data Exchange (ETDEWEB)

Gowda, H S; Achar, B N [Mysore Univ. (India). Dept. of Chemistry

1980-01-01

Tetrasodium salts of copper(II) 4,4', 4'', 4'''-tetrasulphophthalocyanine 2-hydrate, nickel(II) 4,4', 4'', 4'''-tetrasulphophthalocyanine, nickel(II) 3,3', 3'', 3'''-tetrasulphophthalocyanine and cobalt(II) 4,4', 4'', 4'''-tetrasulphophthalocyanine 2-hydrate, and copper phthalocyanine trisulphonic acid are prepared in pure state. The molar absorptivity and formal redox potentials of the complexes are determined. The complexes are proposed as sensitive redox indicators in the micro determination of iron(II), arsenic(III), molybdenum(V), uranium(IV) and hydroquinone with 0.001-0.0005N cerium(IV) sulphate in sulphuric, hydrochloric and acetic acid media. They give sharp colour change from light turquoise blue to pale purple colour at the equivalence point. They have advantages over a few existing redox indicators.

Comparison of treatment outcome using two definitions of rapid cycling in subjects with bipolar II disorder.

Science.gov (United States)

Amsterdam, Jay D; Lorenzo-Luaces, Lorenzo; DeRubeis, Robert J

2017-02-01

We examined differences in treatment outcome between Diagnostic and Statistical Manual Fourth Edition (DSM-IV)-defined rapid cycling and average lifetime-defined rapid cycling in subjects with bipolar II disorder. We hypothesized that, compared with the DSM-IV definition, the average lifetime definition of rapid cycling may better identify subjects with a history of more mood lability and a greater likelihood of hypomanic symptom induction during long-term treatment. Subjects ≥18 years old with a bipolar II major depressive episode (n=129) were categorized into DSM-IV- and average lifetime-defined rapid cycling and prospectively treated with either venlafaxine or lithium monotherapy for 12 weeks. Responders (n=59) received continuation monotherapy for six additional months. These exploratory analyses found moderate agreement between the two rapid-cycling definitions (κ=0.56). The lifetime definition captured subjects with more chronic courses of bipolar II depression, whereas the DSM-IV definition captured subjects with more acute symptoms of hypomania. There was no difference between rapid-cycling definitions with respect to the response to acute venlafaxine or lithium monotherapy. However, the lifetime definition was slightly superior to the DSM-IV definition in identifying subjects who went on to experience hypomanic symptoms during continuation therapy. Although sample sizes were limited, the findings suggest that the lifetime definition of rapid cycling may identify individuals with a chronic rapid-cycling course and may also be slightly superior to the DSM-IV definition in identifying individuals with hypomania during relapse-prevention therapy. These findings are preliminary in nature and need replication in larger, prospective, bipolar II studies. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

SNEAK-4, a series of physics experiments for KNK II

International Nuclear Information System (INIS)

Engelmann, P.

1969-10-01

At the end of 1968 a three months program of neutron physics experiments was performed at SNEAK for the investigation of some nuclear properties of the KNK II reactor. The experiments were conducted by the Karlsruhe Nuclear Research Center in close cooperation with INTERATOM. The results of the measurements on SNEAK assemblies 4A and 4B are reported and compared with calculations. The experimental results of critical mass and reactivities, control rod worths, Doppler coefficient and power distribution were used to draw conclusions for the KNK II design

Crystal structure of dilead(II oxochromate(VI oxotellurate(IV

Directory of Open Access Journals (Sweden)

Matthias Weil

2017-06-01

Full Text Available Reaction of chromium(III precursors with TeO2 in PbF2/PbO melts in air led to oxidation of chromium(III to chromium(VI, whereas tellurium remained its oxidation state of IV. In the resulting title compound, Pb2(CrO4(TeO3, the two types of anions are isolated from each other, hence a double salt is formed. The two independent Pb2+ cations exhibit coordination number nine under formation of very distorted coordination polyhedra [bond-length range = 2.363 (6–3.276 (7 Å]. The oxochromate(VI and oxotellurate(IV anions have tetrahedral and trigonal–pyramidal configurations, respectively. In the crystal structure, (001 layers of metal cations alternate with layers of TeO32− and CrO42− anions along [001], forming a three-dimensional framework structure. Pb2(CrO4(TeO3 is isotypic with its sulfate analogue Pb2(SO4(TeO3 and is comparatively discussed.

Silica-gel Particles Loaded with an Ionic Liquid for Separation of Zr(IV Prior to Its Determination by ICP-OES

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Hadi M. Marwani

2016-06-01

Full Text Available A new ionic liquid loaded silica gel amine (SG-APTMS-N,N-EPANTf2 was developed, as an adsorptive material, for selective adsorption and determination of zirconium, Zr(IV, without the need for a chelating intermediate. Based on a selectivity study, the SG-APTMS-N,N-EPANTf2 phase showed a perfect selectivity towards Zr(IV at pH 4 as compared to other metallic ions, including gold [Au(III], copper [Cu(II], cobalt [Co(II], chromium [Cr(III], lead [Pb(II], selenium [Se(IV] and mercury [Hg(II] ions. The influence of pH, Zr(IV concentration, contact time and interfering ions on SG-APTMS-N,N-EPANTf2 uptake for Zr(IV was evaluated. The presence of incorporated donor atoms in newly synthesized SG-APTMS-N,N-EPANTf2 phase played a significant role in enhancing its uptake capacity of Zr(IV by 78.64% in contrast to silica gel (activated. The equilibrium and kinetic information of Zr(IV adsorption onto SG-APTMS-N,N-EPANTf2 were best expressed by Langmuir and pseudo second-order kinetic models, respectively. General co-existing cations did not interfere with the extraction and detection of Zr(IV. Finally, the analytical efficiency of the newly developed method was also confirmed by implementing it for the determination of Zr(IV in several water samples.

Extractive Spectrophotometric Determination of Nortriptyline Hydrochloride Using Sudan II, IV and Black B

Directory of Open Access Journals (Sweden)

A. S. Amin

2017-08-01

formulations based on the formation of ion-pair complexes with sudun II (SII, sudan (IV (SIV and sudan black B (SBB. The selectivity of the method was improved through extraction with chloroform. The optimum conditions for complete extracted colour development were assessed. The absorbance measurements were made at 534, 596 and 649 nm for SII, SIV and SBB complexes, respectively. The calibration graph was linear in the ranges 0.5- 280. 0.5- 37.5 and 0.5 – 31.0 μg ml−1 of the drug usiny the same reagents, respectively. The precision of the procedure was checked by calculating the relative standard deviation of ten replicate determinations on 15 μg ml−1 of nortriptyline HCI and was found to be 1.7, 1.3 and 1.55% using SII, SIV, and SBB complexes, respectively. The molar absorptivity and Sandell sensitivity for each ion-pair were calculated. The proposed methods were successfully applied to the deterniination of pure nortriptyline HCI and in pharmaceutical formulations, and the results demonstrated that the method is equally accurate, precise and reproducible as the official method.

Investigation of resonant Raman scattering in type II GaAs/AlAs superlattices

International Nuclear Information System (INIS)

Choi, H.

2001-01-01

As a consequence of the band alignment in GaAs/AIAs superlattices (SLs) and the indirect nature of bulk AIAs, quantum confinement can be used to engineer a Type II system. This produces an electron population in the AIAs longitudinal (X z ) or transverse (X xy ) zone-edge states, which is separated in both direct and reciprocal space from the hole population in the GaAs zone-centre (Γ) states. This thesis is an investigation of the electronic and vibrational structure of Type II GaAs/AIAs SLs using theoretical models and spectroscopic techniques, with special emphasis on Type II resonant Raman (RR) scattering. The majority of this thesis concerns short-period GaAs/AIAs SLs with X z as the lowest conduction band state. A model of the SL electronic band structure is presented, including the effects of interband Γ-X z mixing and the X-point camel's back structure. Interband mixing makes Γ-X z radiative transitions observable in photoluminescence (PL) and RR experiments. Phonon-assisted transitions from the X z state are also observed in PL experiments. Several of the participating phonon modes are unambiguously identified, in good agreement with recent reports. This thesis presents the first detailed experimental and theoretical study of Type II RR scattering from the incoming channel of the X z -related Type II bandgap. The X z - related Type II incoming RR spectra in the GaAs optic phonon region are compared with the Γ-related Type I outgoing RR spectra within several theoretical models. Thereby, the mechanisms of the Type II RR scattering, the origins of the RR lineshape and the polarisation dependence, are fully explained, clarifying the spectral features observed in the GaAs zone-centre optic phonon region. The Type II resonance also allows the observation of zone boundary (X-point) phonons from intervalley (IV) scattering. A model of the IV electron-phonon interaction involving X conduction band electrons and zone boundary phonons in Type II SLs is presented

LHC Experiments Phase II - TDRs Approval Process

CERN Document Server

Forti, F

2017-01-01

The overall review process and steps of Phase II were described in CERN-LHCC-2015-077. As experiments submit detailed technical design reports (TDRs), the LHCC and UCG work in close connection to ensure a timely review of the scientific and technical feasibility as well as of the budget and schedule of the upgrade programme.

Experience in maintenance of pumps in test facilities at R.E.D., B.A.R.C. [Paper No.: II-5

International Nuclear Information System (INIS)

Nangia, H.V.; Soni, K.L.; Kamath, K.V.; Mahajan, S.C.

1981-01-01

Centrifugal pumps are used for circulating water in various test facilities which are meant for testing reactor components. Operating pressures are about 85 bars at 250 degC. Reciprocating pumps are used for make up service at pressures upto 160 bars. A primary heat transport pump for 200 MWe Candu type reactor, is being tested for checking its performance and for collection of base data. The following are discussed: (i) failure of hydrostatic seal and hydrostatic bearing and its causes, (ii) subsequent repairs and reconditioning, (iii) steps taken to avoid repetition of such failures, and (iv) problems in assembly. For a pump used in the fuelling machine test facility, following maintenance problems are discussed: (1) failure of various components like bearings, mechanical, seals, wear rings, etc., (2) causes of failure and steps taken to remedy the deficiencies noted, (3) experience with the indigenous antifriction bearings, and (4) experience with indigenous spiral wound gaskets. For the reciprocating pumps, leakage through gland packing is a problem. Experience with various types of packing and other parameters, affecting leakage are discussed. (author)

FISA-2009 Conference on Euratom Research and Training Activities: Nuclear Fission - Past, Present and Future (Generation-II, -III and -IV + Partitioning and Transmutation)

International Nuclear Information System (INIS)

Bhatnagar, V.; Deffrennes, M.; Hugon, M.; Manolatos, P.; Ptackova, K.; Van Goethem, G.; Webster, S.

2011-01-01

This paper is an introduction to the research and training activities carried out under the Euratom 7th Framework Programme (FP7, 2007-2011) in the field of nuclear fission science and technology, covering in particular nuclear systems and safety, and including innovative reactor systems and partitioning and transmutation. It is based on the more than 40 invited lectures that were delivered by Euratom project coordinators and keynote speakers at the FISA-2009 Conference (), organised by the European Commission DG Research, 22-24 June 2009, Prague, Czech Republic. The Euratom programme must be considered in the context of current and future nuclear technology and the respective research effort: ·Generation-II (i.e. yesterday, NPP construction 1970-2000): safety and reliability of nuclear facilities and energy independence in order to ensure security of supply worldwide; ·Generation-III (i.e. today, construction 2000-2040+): continuous improvement of safety and reliability, and increased industrial competitiveness in a growing energy market; ·Generation-IV (i.e. tomorrow, construction from 2040) for increased sustainability though optimal utilisation of natural resources and waste minimisation, and increased proliferation resistance. Consequently, the focus of the lectures devoted to Generation-II and -III is on the major scientific challenges and technological developments needed to guarantee safety and reliability, in particular issues associated with plant lifetime extension and operation. The focus of the lectures devoted to Generation-IV is on the design objectives and associated research issues that have been agreed upon internationally, in particular the ambitious criteria and technology goals established at the international level by the Generation-IV International Forum (GIF). In the future, electricity must continue to be produced competitively, and in addition high temperature process heat may also be required, while exploiting a maximum of fissile and

Report for 2012 from the Bordeaux IVS Analysis Center

Science.gov (United States)

Charlot, Patrick; Bellanger, Antoine; Bouffet, Romuald; Bourda, Geraldine; Collioud, Arnaud; Baudry, Alain

2013-01-01

This report summarizes the activities of the Bordeaux IVS Analysis Center during the year 2012. The work focused on (i) regular analysis of the IVS-R1 and IVS-R4 sessions with the GINS software package; (ii) systematic VLBI imaging of the RDV sessions and calculation of the corresponding source structure index and compactness values; (iii) investigation of the correlation between astrometric position instabilities and source structure variations; and (iv) continuation of our VLBI observational program to identify optically-bright radio sources suitable for the link with the future Gaia frame. Also of importance is the 11th European VLBI Network Symposium, which we organized last October in Bordeaux and which drew much attention from the European and International VLBI communities.

Prompt Burst Energetics (PBE) experiment analyses using the SIMMER-II computer code

International Nuclear Information System (INIS)

Tomkins, J.L.; Hitchcock, J.T.; Young, M.F.

1979-01-01

Two of the Prompt Burst Energetics (PBE) in-pile experiments conducted at Sandia Laboratories PBE-5S and PBE-SG2, have been investigated with SIMMER-II. These two tests utilize fresh uranium oxide and fresh uranium carbide pins, respectively, in stagnant sodium. The purpose of the analysis is to investigate the applicability of SIMMER-II to this type of experiment. Qualitative agreement with measured data is seen for PBE-5S. PBE-SG2 results agree somewhat less well but demonstrate SIMMER-II's potential for describing fuel-coolant-interactions with further model development

Catalytic properties of RNA polymerases IV and V: accuracy, nucleotide incorporation and rNTP/dNTP discrimination.

Science.gov (United States)

Marasco, Michelle; Li, Weiyi; Lynch, Michael; Pikaard, Craig S

2017-11-02

All eukaryotes have three essential nuclear multisubunit RNA polymerases, abbreviated as Pol I, Pol II and Pol III. Plants are remarkable in having two additional multisubunit RNA polymerases, Pol IV and Pol V, which synthesize noncoding RNAs that coordinate RNA-directed DNA methylation for silencing of transposons and a subset of genes. Based on their subunit compositions, Pols IV and V clearly evolved as specialized forms of Pol II, but their catalytic properties remain undefined. Here, we show that Pols IV and V differ from one another, and Pol II, in nucleotide incorporation rate, transcriptional accuracy and the ability to discriminate between ribonucleotides and deoxyribonucleotides. Pol IV transcription is considerably more error-prone than Pols II or V, which may be tolerable in its synthesis of short RNAs that serve as precursors for siRNAs targeting non-identical members of transposon families. By contrast, Pol V exhibits high fidelity transcription, similar to Pol II, suggesting a need for Pol V transcripts to faithfully reflect the DNA sequence of target loci to which siRNA-Argonaute silencing complexes are recruited. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

SPQR II: A beam-plasma interaction experiment

Science.gov (United States)

Bimbot, R.; Della-Negra, S.; Gardès, D.; Rivet, M. F.; Fleurier, C.; Dumax, B.; Hoffman, D. H. H.; Weyrich, K.; Deutsch, C.; Maynard, G.

1986-01-01

SPQR II is an interaction experiment designed to probe energy -and charge-exchange of Cn+ ions at 2 MeV/a.m.u., flowing through a fully ionized plasma column of hydrogen with nℓ=1019 e-cm-2 at T=5 eV. One expects a factor of two enhanced stopping over the cold gas case.

Experiment to study K+ → π+ + ''nothing'' at LAMPF II

International Nuclear Information System (INIS)

Marlow, D.R.

1985-05-01

An experiment to measure K + → π + + ''nothing'' (where ''nothing'' denotes unobservable neutral particles) at LAMPF II is described. This experiment is capable of measuring one K + → π + nu anti nu event for branching ratio of 10 -12 . 12 refs

OWR/RTNS-II low exposure spectral effects experiment

International Nuclear Information System (INIS)

Heinisch, H.L.

1985-05-01

The first RTNS-II irradiation of the Low Exposure Spectral Experiment has been completed. The dosimetry has been analyzed, and expressions have been determined that fit the data very well. The effects of including the angular variation of the neutron spectrum were investigated

Can we improve C IV-based single epoch black hole mass estimations?

Science.gov (United States)

Mejía-Restrepo, J. E.; Trakhtenbrot, B.; Lira, P.; Netzer, H.

2018-05-01

In large optical surveys at high redshifts (z > 2), the C IV broad emission line is the most practical alternative to estimate the mass (MBH) of active super-massive black holes (SMBHs). However, mass determinations obtained with this line are known to be highly uncertain. In this work we use the Sloan Digital Sky Survey Data Release 7 and 12 quasar catalogues to statistically test three alternative methods put forward in the literature to improve C IV-based MBH estimations. These methods are constructed from correlations between the ratio of the C IV line-width to the low ionization line-widths (Hα, Hβ and Mg II) and several other properties of rest-frame UV emission lines. Our analysis suggests that these correction methods are of limited applicability, mostly because all of them depend on correlations that are driven by the linewidth of the C IV profile itself and not by an interconnection between the linewidth of the C IV line with the linewidth of the low ionization lines. Our results show that optical C IV-based mass estimates at high redshift cannot be a proper replacement for estimates based on IR spectroscopy of low ionization lines like Hα, Hβ and Mg II.

Improved recovery of trace amounts of gold (III), palladium (II) and platinum (IV) from large amounts of associated base metals using anion-exchange resins

Energy Technology Data Exchange (ETDEWEB)

Matsubara, I. [Lab. of Chemistry, Tokyo Women' s Medical Univ. (Japan); Takeda, Y.; Ishida, K. [Lab. of Chemistry, Nippon Medical School, Kawasaki-shi, Kanagawa-ken (Japan)

2000-02-01

The adsorption and desorption behaviors of gold (III), palladium (II) and platinum (IV) were surveyed in column chromatographic systems consisting of one of the conventional anion-exchange resins of large ion-exchange capacity and dilute thiourea solutions. The noble metals were strongly adsorbed on the anion-exchange resins from dilute hydrochloric acid, while most base metals did not show any marked adsorbability. These facts made it possible to separate the noble metals from a large quantity of base metals such as Ag (I), Al (III), Co (II), Cu (II), Fe (III), Mn (II), Ni (II), Pb (II), and Zn (II). Although it used to be very difficult to desorb the noble metals from the resins used, the difficulty was easily overcome by use of dilute thiourea solutions as an eluant. In the present study, as little as 1.00 {mu}g of the respective noble metals was quantitatively separated and recovered from as much as ca. 10 mg of a number of metals on a small column by elution with a small amount of dilute thiourea solution. The present systems should be applicable to the separation, concentration and recovery of traces of the noble metals from a number of base metals coexisting in a more extended range of amounts and ratios. (orig.)

Title IV Quality Control Project, Stage II. Management Option II: Delivery System Quality Improvements.

Science.gov (United States)

Advanced Technology, Inc., Reston, VA.

Stage Two of the Title IV Quality Control Project is an integrated study of quality in five related Federal financial aid programs for postsecondary students. Section 1 of the paper establishes a framework for defining quality improvements, in order to identify the types of changes that would tend to improve quality across all facets of the…

Motion of the sources for type II and type IV radio bursts and flare-associated interplanetary disturbances

Science.gov (United States)

Sakurai, K.; Chao, J. K.

1974-01-01

Shock waves are indirectly observed as the source of type II radio bursts, whereas magnetic bottles are identified as the source of moving metric type IV radio bursts. The difference between the expansion speeds of these waves and bottles is examined during their generation and propagation near the flare regions. It is shown that, although generated in the explosive phase of flares, the bottles behave quite differently from the waves and that the bottles are generally much slower than the waves. It has been suggested that the waves are related to flare-associated interplanetary disturbances which produce SSC geomagnetic storms. These disturbances may, therefore, be identified as interplanetary shock waves. The relationship among magnetic bottles, shock waves near the sun, and flare-associated disturbances in interplanetary space is briefly discussed.

Clinical significance of determination of serum collagen type IV (IV-C) and transforming growth factor beta1(TGF-β1) levels in patients with diabetic nephropathy

International Nuclear Information System (INIS)

Xie Hongfang; Peng Liang

2006-01-01

Objective: To investigate the clinical significance of determination of serum collagen type IV (IV-C) and transforming growth factor beta 1 (TGF-β 1 ) levels in patients with diabetic nephropathy. Methods: Serum IV-C levels ( with RIA) and TGF-β 1 levels (with ELISA) were determined in 30 controls and 105 patients with type II diabetis mellitus (45 with diabetic nephropathy and 60 without nephropathy). Results: The serum levels of IV-C and TGF-β 1 in diabetic patients with nephropathy were significantly higher than those in controls (P 0.05). Conclusion: Serum IV-C and TGF-β 1 , levels increased gradually as the diabetic nephropathy got more severe, they could be used as sensitive markers for early diagnosis of development of diabetic nephropathy. (authors)

Facile and reversible formation of iron(III)-oxo-cerium(IV) adducts from nonheme oxoiron(IV) complexes and cerium(III)

Energy Technology Data Exchange (ETDEWEB)

Draksharapu, Apparao; Rasheed, Waqas; Klein, Johannes E.M.N.; Que, Lawrence Jr. [Department of Chemistry and Center for Metals in Biocatalysis, University of Minnesota, Minneapolis, MN (United States)

2017-07-24

Ceric ammonium nitrate (CAN) or Ce{sup IV}(NH{sub 4}){sub 2}(NO{sub 3}){sub 6} is often used in artificial water oxidation and generally considered to be an outer-sphere oxidant. Herein we report the spectroscopic and crystallographic characterization of [(N4Py)Fe{sup III}-O-Ce{sup IV}(OH{sub 2})(NO{sub 3}){sub 4}]{sup +} (3), a complex obtained from the reaction of [(N4Py)Fe{sup II}(NCMe)]{sup 2+} with 2 equiv CAN or [(N4Py)Fe{sup IV}=O]{sup 2+} (2) with Ce{sup III}(NO{sub 3}){sub 3} in MeCN. Surprisingly, the formation of 3 is reversible, the position of the equilibrium being dependent on the MeCN/water ratio of the solvent. These results suggest that the Fe{sup IV} and Ce{sup IV} centers have comparable reduction potentials. Moreover, the equilibrium entails a change in iron spin state, from S=1 Fe{sup IV} in 2 to S=5/2 in 3, which is found to be facile despite the formal spin-forbidden nature of this process. This observation suggests that Fe{sup IV}=O complexes may avail of reaction pathways involving multiple spin states having little or no barrier. (copyright 2017 Wiley-VCH Verlag GmbH and Co. KGaA, Weinheim)

Peningkatan Partisipasi Siswa Kelas IV dalam Pembelajaran IPS melalui Media Kartu Di SDN 22 IV Koto Aur Malintang Kabupaten Padang Pariaman

Directory of Open Access Journals (Sweden)

Daswinar Daswinar

2016-04-01

Full Text Available Factor that causes student participation under communication in social science study (IPS still internel study process in teacher, monotonous study,  and impress a little stiff, so that make student inclined feel tense and satisfied in learn. potencial student to think, critical,  and ask, take outside opinion doesn't bloom well, so to increase student participation in study, teacher be  demanded to use strategy that can involve student mobilety. Teacher success in teach doesn't quit of teacher know-how use and choose media and method in study. Watchfulness internal issue formulation how does class student participation enhanced IV in study IPS by using card media at country elementary school. Aim from this watchfulness describes student participation enhanced in study ips pass card media in class IV. country elementary school. Hypothesis that proposed in this watchfulness with card media can be increased class student participation IV in study IPS at country. Watchfulness method that applied class action watchfulness method. Subjek watchfulness class student IV SD. Watchfulness result data student participation data and teacher activity during study in class. In hypothesis testing is used student participation percentage enhanced in study execution in use card media. Data analysis result data is got average participation percentage in my cycle I is 42,56% and cycle II 74,47% happen student participation enhanced from my cycle to cycle ii as much as 25%. Inferential with card media can be increased class student participation IV country elementary school. Conection with watchfulness result that got above so as suggestion in increase student participation, teacher can use card media in study IPS

Entdeckung elektroschwacher Produktion einzelner Top-Quarks mit dem CDF II Experiment; Discovery electroweak production of single top quarks with the CDF II Experiment

Energy Technology Data Exchange (ETDEWEB)

Luck, Jan [Karlsruhe Inst. of Technology (KIT) (Germany)

2009-01-01

This thesis presents a neural network search for combined as well as separate s- and t-channel single top-quark production with the CDF II experiment at the Tevatron using 3.2 fb^-1 of collision data. It is the twelfth thesis dealing with single top-quark production performed within the CDF Collaboration, whereas three have been done in Run I [53–55] and eight in Run II [23, 25, 28, 39, 56–59].

FALSIRE Phase II. CSNI project for Fracture Analyses of Large-Scale International Reference Experiments (Phase II). Comparison report

International Nuclear Information System (INIS)

Sievers, J.; Schulz, H.; Bass, R.; Pugh, C.; Keeney, J.

1996-11-01

A summary of Phase II of the Project for Fracture Analysis of Large-Scale International Reference Experiments (FALSIRE) is presented. A FALSIRE II Workshop focused on analyses of reference fracture experiments. More than 30 participants representing 22 organizations from 12 countries took part in the workshop. Final results for 45 analyses of the reference experiments were received from the participating analysts. For each experiment, analysis results provided estimates of variables that include temperature, crack-mouth-opening displacement, stress, strain, and applied K and J values. The data were sent electronically to the Organizing Committee, who assembled the results into a comparative data base using a special-purpose computer program. A comparative assessment and discussion of the analysis results are presented in the report. Generally, structural responses of the test specimens were predicted with tolerable scatter bands. (orig./DG)

The carbonate complexation of plutonium(IV)

International Nuclear Information System (INIS)

Hobart, D.E.; Palmer, P.D.; Newton, T.W.

1985-01-01

Plutonium(IV) carbonate complexes are expected to be of particular importance in typical groundwaters at the Yucca Mountain site of the candidate nuclear waste repository being studied by the Nevada Nuclear Waste Storage Investigations Project. The chemistry of these complexes is also important in the areas of nuclear fuel reprocessing and purification, actinide separations, and environmental studies. This report describes initial experiments performed to determine the identity and equilibrium quotients of plutonium(IV) carbonate complexes. These experiments were performed at pH values between 7.2 and 9.6 using a spectrophotometric method. In addition, a brief review of the published literature on Pu(IV) carbonate complexes is presented. Since Pu(IV) exhibits low solubility in the near-neutral pH range, a complex-competition reaction where citrate ligands compete with carbonate ions for the plutonium will be employed. This will permit us to study the pure carbonate system; study the mixed carbonate/citrate system, and confirm and extend the literature work on the pure citrate system. The current experiments have demonstrated the existence of at least three distinct species in the pH region studied. This work will continue in the extended study of the pure citrate system, followed by the investigation of the citrate/carbonate complex/competition reaction. 9 refs., 4 figs., 2 tabs

Mechanism of reductive elimination. Reaction of alkylpalladium(II) complexes with tetraorganotin, organolithium, and Grignard reagents. Evidence for palladium(IV) intermediacy

International Nuclear Information System (INIS)

Milstein, D.; Stille, J.K.

1979-01-01

Coupling products are obtained in good yields from the reaction of tetraorganotin compounds or Grignard reagents and organohalogenopalladium(II) complexes provided that a benzyl bromide is present. Low yields are obtained in the absence of the benzyl bromides, in which case other decomposition pathways (e.g., α elimination) take place, even in the presence of electron acceptors (e.g., oxygen, m-dinitrobenzene). The first step in the reaction of benzylhalogenobis(triphenylphosphine)-palladium(II) complexes with MeM (M = SnMe 3 , MgBr) is metathesis of the benzyl ligand rather than the halogen. This unique carbon-for-carbon transmetalation takes place at 25 0 C and is facilitated by electron-donating substituents on the benzyl ligand. The products of this reaction subsequently react at higher temperature in the presence of a benzyl bromide to afford ethylbenzene. Optically active chloro-(α-deuteriobenzyl)bis(triphenylphosphine)palladium yields, upon reaction with tetramethyltin in the presence of p-nitrobenzyl bromide, optically active α-deuterioethylbenzene in which overall retention of configuration at carbon has resulted. cis-dimethylbis(triphenylphosphine)palladium(II) reacts with benzyl bromide at 25 0 C to afford ethylbenzene and bromomethylbis(triphenylphosphine)palladium(II) rather than ethane. When optically active α-deuteriobenzyl bromide is used in this reaction, optically active α-deuterioethylbenzene is formed, and inversion of configuration at carbon takes place. The reductive elimination process is proposed to take place preferentially from a palladium(IV) intermediate with retention of configuration at carbon

Overview of TJ-II experiments

International Nuclear Information System (INIS)

Alejaldre, C.; Alonso, J.; Almoguera, L.

2005-01-01

This paper presents an overview of experimental results and progress made in investigating the role of magnetic configuration on stability and transport in the TJ-II stellarator. Global confinement studies have revealed a positive dependence of energy confinement on the rotational transform and plasma density, together with different parametric dependences for metallic and boronised wall conditions. Spontaneous and biasing-induced improved confinement transitions, with some characteristics that resemble those of previously reported H-mode regimes in other stellarator devices, have been observed. Also, magnetic configuration scan experiments have shown an interplay between magnetic structure (rationals, magnetic shear), transport and electric fields. Although the DC radial electric fields are comparable with those expected from neoclassical calculations, additional mechanisms based on neoclassical/turbulent bifurcations and kinetic effects are needed to explain the impact of magnetic topology on flows and radial electric fields. Local transport studies have demonstrated a dependence of plasma diffusivities and convective velocities on plasma density and heating power in consistency with global confinement properties. Hydrocarbon fuelling experiments in configurations with a low order rational value in the rotational transform located in the proximity of the last close flux surface (n = 4/m = 2) have shown the impurity screening properties related to the expected divertor effect. First experiments in NBI plasmas are reported. (author)

Zwitterion-functionalized polymer microspheres as a sorbent for solid phase extraction of trace levels of V(V), Cr(III), As(III), Sn(IV), Sb(III) and Hg(II) prior to their determination by ICP-MS.

Science.gov (United States)

Jia, Xiaoyu; Gong, Dirong; Zhao, Junyi; Ren, Hongyun; Wang, Jiani; Zhang, Xian

2018-03-19

This paper describes the preparation of zwitterion-functionalized polymer microspheres (ZPMs) and their application to simultaneous enrichment of V(V), Cr(III), As(III), Sn(IV), Sb(III) and Hg(II) from environmental water samples. The ZPMs were prepared by emulsion copolymerization of ethyl methacrylate, 2-diethylaminoethyl methacrylate and triethylene glycol dimethyl acrylate followed by modification with 1,3-propanesultone. The components were analyzed by elemental analyses as well as Fourier transform infrared spectroscopy, and the structures were characterized by scanning electron microscopy and transmission electron microscopy. The ZPMs were packed into a mini-column for on-line solid-phase extraction (SPE) of the above metal ions. Following extraction with 40 mM NH 4 NO 3 and 0.5 M HNO 3 solution, the ions were quantified by ICP-MS. Under the optimized conditions, the enrichment factors (from a 40 mL sample) are up to 60 for the ions V(V), As(III), Sb(III) and Hg(II), and 55 for Cr(III) and Sn(IV). The detection limits are 1.2, 3.4, 1.0, 3.7, 2.1 and 1.6 ng L -1 for V(V), Cr(III), As(III), Sn(IV), Sb(III) and Hg(II), respectively, and the relative standard deviations (RSDs) are below 5.2%. The feasibility and accuracy of the method were validated by successfully analyzing six certified reference materials as well as lake, well and river waters. Graphical abstract Zwitterion-functionalized polymer microspheres (ZPMs) were prepared and packed into a mini-column for on-line solid-phase extraction (SPE) via pump 1. Then V(V), Cr(III), As(III), Sn(IV), Sb(III) and Hg(II) ions in environmental waters were eluted and submitted to ICP-MS via pump 2.

Materials for generation-IV nuclear reactors

International Nuclear Information System (INIS)

Alvarez, M. G.

2009-01-01

Materials science and materials development are key issues for the implementation of innovative reactor systems such as those defined in the framework of the Generation IV. Six systems have been selected for Generation IV consideration: gas-cooled fast reactor, lead-cooled fast reactor, molten salt-cooled reactor, sodium-cooled fast reactor, supercritical water-cooled reactor, and very high temperature reactor. The structural materials need to resist much higher temperatures, higher neutron doses and extremely corrosive environment, which are beyond the experience of the current nuclear power plants. For this reason, the first consideration in the development of Generation-IV concepts is selection and deployment of materials that operate successfully in the aggressive operating environments expected in the Gen-IV concepts. This paper summarizes the Gen-IV operating environments and describes the various candidate materials under consideration for use in different structural applications. (author)

Audiological findings in children with mucopolysaccharidoses type i-iv.

Science.gov (United States)

Vargas-Gamarra, María F; de Paula-Vernetta, Carlos; Vitoria Miñana, Isidro; Ibañez-Alcañiz, Isabel; Cavallé-Garrido, Laura; Alamar-Velazquez, Agustín

The aim of our study is to reflect hearing impairment of 23children diagnosed with mucopolysaccharidosis (MPS) typeI, II, III and IV. Retrospective study of the clinical, audiological and treatment (medical vs surgical) findings of 23children diagnosed with MPS typeI, II, III or IV followed at a Tertiary Referral Hospital between 1997 and 2015. Six cases of MPSI, 8 of MPSII, 4 of MPSIII and 5 of MPSIV were reviewed. 71.2% of patients had secretory otitis media (SOM) and 54% of patients had some type of hearing loss (HL). The behaviour of hearing loss was variable in each of the subgroups of MPS, finding greater involvement and variability in typesI and II. Children with MPS have a high risk of hearing loss. A significant percentage of transmissive HL progressing to mixed or sensorineural HL was observed. This was more common in typesI and II. Periodic follow up of these patients is mandatory because of hearing impairment and consequences for their development and quality of life. Copyright © 2016 Elsevier España, S.L.U. and Sociedad Española de Otorrinolaringología y Cirugía de Cabeza y Cuello. All rights reserved.

Characterization of optical systems for the ALPS II experiment

International Nuclear Information System (INIS)

Spector, Aaron D.; Baehre, Robin; Willke, Benno; Hannover Univ.

2016-09-01

ALPS II is a light shining through a wall style experiment that will use the principle of resonant enhancement to boost the conversion and reconversion probabilities of photons to relativistic WISPs. This will require the use of long baseline low-loss optical cavities. Very high power build up factors in the cavities must be achieved in order to reach the design sensitivity of ALPS II. This necessitates a number of different sophisticated optical and control systems to maintain the resonance and ensure maximal coupling between the laser and the cavity. In this paper we report on the results of the characterization of these optical systems with a 20m cavity and discuss the results in the context of ALPS II.

Operating experience of the EBR-II steam generating system

International Nuclear Information System (INIS)

Buschman, H.W.; Penney, W.H.; Quilici, M.D.; Radtke, W.H.

1981-01-01

The Experimental Breeder Reactor II (EBR-II) is a Liquid Metal Fast Breeder Reactor (LMFBR) with integrated power producing capability. Superheated steam is produced by eight natural circulation evaporators, two superheaters, and a conventional steam drum. Steam throttle conditions are 438 C (820 F) and 8.62 MPa (1250 psi). The designs of the evaporators and superheaters are essentially identical; both are counterflow units with low pressure nonradioactive sodium on the shell side. Safety and reliability are maximized by using duplex tubes and tubesheets. The performance of the system has been excellent and essentially trouble free. The operating experience of EBR-II provides confidence that the technology can be applied to commercial LMFBR's for an abundant supply of energy for the future. 5 refs

Pt(IV) complexes as prodrugs for cisplatin.

Science.gov (United States)

Shi, Yi; Liu, Shu-An; Kerwood, Deborah J; Goodisman, Jerry; Dabrowiak, James C

2012-02-01

The antitumor effects of platinum(IV) complexes, considered prodrugs for cisplatin, are believed to be due to biological reduction of Pt(IV) to Pt(II), with the reduction products binding to DNA and other cellular targets. In this work we used pBR322 DNA to capture the products of reduction of oxoplatin, c,t,c-[PtCl(2)(OH)(2)(NH(3))(2)], 3, and a carboxylate-modified analog, c,t,c-[PtCl(2)(OH)(O(2)CCH(2)CH(2)CO(2)H)(NH(3))(2)], 4, by ascorbic acid (AsA) or glutathione (GSH). Since carbonate plays a significant role in the speciation of platinum complexes in solution, we also investigated the effects of carbonate on the reduction/DNA-binding process. In pH 7.4 buffer in the absence of carbonate, both 3 and 4 are reduced by AsA to cisplatin (confirmed using ((195))Pt NMR), which binds to and unwinds closed circular DNA in a manner consistent with the formation of the well-known 1, 2 intrastrand DNA crosslink. However, when GSH is used as the reducing agent for 3 and 4, ((195))Pt NMR shows that cisplatin is not produced in the reaction medium. Although the Pt(II) products bind to closed circular DNA, their effect on the mobility of Form I DNA is different from that produced by cisplatin. When physiological carbonate is present in the reduction medium, ((13))C NMR shows that Pt(II) carbonato complexes form which block or impede platinum binding to DNA. The results of the study vis-à-vis the ability of the Pt(IV) complexes to act as prodrugs for cisplatin are discussed. Copyright © 2011 Elsevier Inc. All rights reserved.

Overview of TJ-II experiments

International Nuclear Information System (INIS)

Sanchez, J.; Acedo, M.; Alonso, A.

2007-01-01

This paper presents an overview of experimental results and progress made in investigating the link between magnetic topology, electric fields and transport in the TJ-II stellarator. The smooth change from positive to negative electric field observed in the core region as the density is raised is correlated with global and local transport data. A statistical description of transport is emerging as a new way to describe the coupling between profiles, plasma flows and turbulence. TJ-II experiments show that the location of rational surfaces inside the plasma can, in some circumstances, provide a trigger for the development of core transitions, providing a critical test for the various models that have been proposed to explain the appearance of transport barriers in relation to magnetic topology. In the plasma core, perpendicular rotation is strongly coupled to plasma density, showing a reversal consistent with neoclassical expectations. In contrast, spontaneous sheared flows in the plasma edge appear to be coupled strongly to plasma turbulence, consistent with the expectation for turbulent driven flows. The local injection of hydrocarbons through a mobile limiter and the erosion produced by plasmas with well-known edge parameters opens the possibility of performing carbon transport studies, relevant for understanding co-deposit formation in fusion devices

Equilibrium between Different Coordination Geometries in Oxidovanadium(IV) Complexes

Science.gov (United States)

Ugone, Valeria; Garribba, Eugenio; Micera, Giovanni; Sanna, Daniele

2015-01-01

In this laboratory activity, the equilibrium between square pyramidal and octahedral V(IV)O[superscript 2+] complexes is described. We propose a set of experiments to synthesize and characterize two types of V(IV)O[superscript 2+] complexes. The experiment allows great flexibility and may be effectively used at a variety of levels and the activity…

EBR-II experience with sodium cleaning and radioactivity decontamination

International Nuclear Information System (INIS)

Ruther, W.E.; Smith, C.R.F.

1978-01-01

The EBR-II is now in Its 13th year of operation. During that period more than 2400 subassemblies have been cleaned of sodium without a serious incident of any kind by a two-step process developed at Argonne. Sodium cleaning and decontamination of other reactor components has been performed only on the relatively few occasions in which a repair or replacement has been required. A summary of the EBR-II experience will be presented. A new facility will be described for the improved cleaning and maintenance of sodium-wetted primary components

EBR-II experience with sodium cleaning and radioactivity decontamination

Energy Technology Data Exchange (ETDEWEB)

Ruther, W E; Smith, C R.F. [Argonne National Laboratory, Argonne (United States)

1978-08-01

The EBR-II is now in Its 13th year of operation. During that period more than 2400 subassemblies have been cleaned of sodium without a serious incident of any kind by a two-step process developed at Argonne. Sodium cleaning and decontamination of other reactor components has been performed only on the relatively few occasions in which a repair or replacement has been required. A summary of the EBR-II experience will be presented. A new facility will be described for the improved cleaning and maintenance of sodium-wetted primary components.

Stark broadening of several Bi IV spectral lines of astrophysical interest

Science.gov (United States)

Colón, C.; Moreno-Díaz, C.; de Andrés-García, I.; Alonso-Medina, A.

2017-09-01

The presence of spectral lines of bismuth in stellar atmospheres has been reported in different stars. The anomalous values of the spectral intensities of Bi II and Bi III, compared to the theoretical Local Termodinamic Equilibrium (LTE) standards of Bi I/Bi II/Bi III, have been reported in the spectra obtained with the High Resolution Spectrograph of the Hubble/Goddard Space Telescope in the chemically peculiar stars HgMn stars χ Lupi and HR 7775. Spectral lines of 1436.8, 1902.3, 2630.9 and 2936.7 Å of Bi II and 1423.4 Å of Bi III were reported and their relative intensities were measured in these studies Litzén & Wahlgren 2002. These lines are overlapped with spectral lines of 1437.65, 2630.1 and 2937.1 Å of Bi IV. A study of the Stark broadening parameters of Bi IV spectral lines can help to study these overlaps. In this paper, using the Griem semi-empirical approach, we report calculated values of the Stark parameters for 64 spectral lines of Bi IV. The matrix elements used in these calculations have been determined from 17 configurations of Bi IV. They were calculated using the cowan code including core polarization effects. Data are displayed for an electron density of 1017 cm-3 and temperatures T = 10 000-160 000 K. Also calculated radiative lifetimes for 12 levels with experimental lifetime are presented, in order to test the goodness of our calculations. Theoretical trends of the Stark width and shift parameters versus the temperature for spectral lines of astrophysical interest are displayed.

ICRF heating experiments on JIPP T-II

International Nuclear Information System (INIS)

Ichimura, M.; Fujita, J.; Hirokura, S.

1983-10-01

Data of JIPP T-II ICRF heating experiments are presented. The experiment covers three typical cases: the low concentration hydrogen minority case, the high concentration hydrogen minority case, and the 3 He minority case. The best heating efficiency is obtained for the 3 Heminority case. It is shown through power balance analysis that the two H-minority cases are different in the wave energy deposition profile. The difference is explained by the presence of local cavity mode for the high concentration minority case. The ion temperature stops rising at the power density level of 0.65 W/cm 3 . An analytic solution of the Fokker-Planck equation is derived to interpret the deterioration of heating efficiency. (author)

On the role of Mn(IV) vacancies in the photoreductive dissolution of hexagonal birnessite

Energy Technology Data Exchange (ETDEWEB)

Kwon, K.D.; Refson, K.; Sposito, G.

2009-06-01

Photoreductive dissolution of layer type Mn(IV) oxides (birnessite) under sunlight illumination to form soluble Mn(II) has been observed in both field and laboratory settings, leading to a consensus that this process is a key driver of the biogeochemical cycling of Mn in the euphotic zones of marine and freshwater ecosystems. However, the underlying mechanisms for the process remain unknown, although they have been linked to the semiconducting characteristics of hexagonal birnessite, the ubiquitous Mn(IV) oxide produced mainly by bacterial oxidation of soluble Mn(II). One of the universal properties of this biogenic mineral is the presence of Mn(IV) vacancies, long-identified as strong adsorption sites for metal cations. In this paper, the possible role of Mn vacancies in photoreductive dissolution is investigated theoretically using quantum mechanical calculations based on spin-polarized density functional theory (DFT). Our DFT study demonstrates unequivocally that Mn vacancies significantly reduce the band-gap energy for hexagonal birnessite relative to a hypothetical vacancy-free MnO{sub 2} and thus would increase the concentration of photo-induced electrons available for Mn(IV) reduction upon illumination of the mineral by sunlight. Calculations of the charge distribution in the presence of vacancies, although not fully conclusive, show a clear separation of photo-induced electrons and holes, implying a slow recombination of these charge-carriers that facilitates the two-electron reduction of Mn(IV) to Mn(II).

Generation IV nuclear energy systems: road map and concepts. 2. Generation II Measurement Systems for Generation IV Nuclear Power Plants

International Nuclear Information System (INIS)

Miller, Don W.

2001-01-01

need for substantial research. As we consider I and C systems in Generation IV reactors, we have the opportunity to take a much less 'timid' design philosophy than was taken in the design of I and C systems in the ALWRs. We need to make use of advanced technology to design an I and C system for the Generation IV multi-unit plant designs currently being considered. Such a design should accomplish the following: 1. provides for multi-unit control; 2. contributes to a plant design objective of a very low core damage frequency; 3. maximizes plant thermal efficiency (>50%); 4. maximizes plant capacity factor (>90%); 5. optimizes operability; 6. maximizes maintainability; 7. provides for on-line monitoring, calibration, and diagnostics; 8. provides optimum response to disturbances; 9. provides excellent load-following capability. When we consider the current situation in operating Generation I and II nuclear power plants and even Generation III ALWR design, we conclude that Generation IV reactors should employ at least Generation II measurement systems. Let us first consider data transmission, which is a form of communication, and ask the question: Do new communication-transferring methods by electrons flow in copper wires? The obvious answer is no. Virtually all new communication systems are using some electromagnetic method, such as light, microwaves, HF or VHF radio signals, and virtually no copper wires. When we envision Generation IV nuclear power plants, we should minimize the use of copper wires for data transmission. We should transmit data primarily by fiber optics and various wireless methods, some of which can penetrate thick barriers. Now let us consider sensors. If we use light for data transmission, then we should also use optical-based sensors. We should also take advantage of microprocessors, which provide opportunities to embed 'intelligence' in the sensor that can be used to increase accuracy, stability, and tolerance to external stressors (i.e., radiation

ALT-II toroidal belt limiter biasing experiments on TEXTOR

International Nuclear Information System (INIS)

Doerner, R.; Boedo, J.A.; Gray, D.S.

1991-01-01

Edge electric fields have been related to H-mode-like behaviour. The experiments reported here are an attempt to control the SOL profiles by electrostatic biasing of the full toroidal-belt limiter ALT-II. The specific goals are: influencing the edge particle flows, particle removal, power deposition and the global confinement. The ALT-II pump limiter is a full toroidal belt located at 45 o below the outer midplane and consisting of eight graphite covered blades which can be independently biased. Particle scoops located behind the limiter neutralize and direct the incoming plasma into the pumping ducts. (author) 5 refs., 3 figs

Preparation and characterization of electrically conducting polypyrrole Sn(IV phosphate cation-exchanger and its application as Mn(II ion selective membrane electrode

Directory of Open Access Journals (Sweden)

A.A. Khan

2011-10-01

Full Text Available Polypyrrole Sn(IV phosphate, an organic–inorganic composite cation-exchanger was synthesized via sol-gel mixing of an organic polymer, polypyrrole, into the matrices of the inorganic precipitate of Sn(IV phosphate. The physico-chemical properties of the material were determined using Atomic Absorption Spectrometry (AAS, CHN elemental analysis (inductively coupled plasma mass spectrometry, ICP-MS, UV–VIS spectrophotometry, FTIR (Fourier Transform Infra-Red, SEM (Scanning Electron Microscopy, TGA–DTA (Thermogravimetric Analysis–Differential Thermal Analysis, and XRD (X-ray diffraction. Ion-exchange behavior was observed to characterize the material. On the basis of distribution studies, the material was found to be highly selective for toxic heavy metal ion Mn2+. Due to its selective nature, the material was used as an electroactive component for the construction of an ion-selective membrane electrode. The proposed electrode shows fairly good discrimination of mercury ion over several other inorganic ions. The analytical utility of this electrode was established by employing it as an indicator electrode in electrometric titrations for Mn(II in water.

Baseball II-T, a new target plasma startup experiment

International Nuclear Information System (INIS)

Chargin, A.; Denhoy, B.; Frank, A.; Thomas, S.

1975-01-01

A brief description is given of modifications and additions to the existing Baseball II experiment. These changes will make it possible to study target plasma buildup in a steady-state magnetic field. This experiment, now called Baseball II-T + will use a pellet generator to deliver ammonia pellets into the center of the magnetic mirror field where they will be heated with a 300-J, 50-ns, CO 2 laser. The plasma created by this method will have a density of approximately 10 13 cm -3 and a temperature of about 1 keV. This target plasma will be used for neutral beam injection startup studies with a 50-A, 20-keV neutral beam. Later, the beam power will be increased to study buildup. With ion injection energies of up to 50 keV, it may be possible to achieve etatau as high as 10 12 cm -3 s. The new components necessary to achieve these goals are described

The First Year of the BABAR Experiment at PEP-II

Energy Technology Data Exchange (ETDEWEB)

Barrera, Barbara

2000-12-18

The BABAR detector, situated at the SLAC PEP-II asymmetric e{sup +}e{sup -} collider, has been recording data at energies on and around the {Upsilon}(4S) resonance since May 1999. In this paper, we briefly describe the PEP-II B Factory and the BABAR detector. The performance presently achieved by the experiment in the areas of tracking, vertexing, calorimetry and particle identification is reviewed. Analysis concepts that are used in the various papers submitted to this conference are also discussed.

Solubility studies of Np(IV)

International Nuclear Information System (INIS)

Zhang Yingjie; Yao Jun; Jiao Haiyang; Ren Lihong; Zhou Duo; Fan Xianhua

2001-01-01

The solubility of Np(IV) in simulated underground water and redistilled water has been measured with the variations of pH(6-12) and storage time (0-100 d) in the presence of reductant (Na 2 S 2 O 4 , metallic Fe). All experiments are performed in a low oxygen concentration glove box containing high purity Ar(99.99%), with an oxygen content of less than 5 x 10 -6 mol/mol. Experimental results show that the variation of pH in solution has little effect on the solubility of Np(IV) in the two kinds of water; the measured solubility of Np(IV) is affected by the composition of solution; with Na 2 S 2 O 4 as a reductant, the solubility of Np(IV) in simulated underground water is (9.23 +- 0.48) x 10 -10 mol/L, and that in redistilled water is (8.31 +- 0.35) x 10 -10 mol/L; with metallic Fe as a reductant, the solubility of Np(IV) in simulated underground water is (1.85 +- 0.56) x 10 -9 mol/L, and that in redistilled water is (1.48 +- 0.66) x 10 -9 mol/L

Enhanced Design Alternative IV

International Nuclear Information System (INIS)

Kramer, N.E.

1999-01-01

This report evaluates Enhanced Design Alternative (EDA) IV as part of the second phase of the License Application Design Selection (LADS) effort. The EDA IV concept was compared to the VA reference design using criteria from the Design Input Request for LADS Phase II EDA Evaluations (CRWMS M and O 1999b) and (CRWMS M and O 1999f). Briefly, the EDA IV concept arranges the waste packages close together in an emplacement configuration known as line load. Continuous pre-closure ventilation keeps the waste packages from exceeding their 350 C cladding and 200 C (4.3.6) drift wall temperature limits. This EDA concept keeps relatively high, uniform emplacement drift temperatures (post-closure) to drive water away from the repository and thus dry out the pillars between emplacement drifts. The waste package is shielded to permit human access to emplacement drifts and includes an integral filler inside the package to reduce the amount of water that can contact the waste form. Closure of the repository is desired 50 years after first waste is emplaced. Both backfill and drip shields will be emplaced at closure to improve post-closure performance. The EDA IV concept includes more defense-in-depth layers than the VA reference design because of its backfill, drip shield, waste package shielding, and integral filler features. These features contribute to the low dose-rate to the public achieved during the first 10,000 years of repository life as shown in Figure 3. Investigation of the EDA IV concept has led to the following general conclusions: (1) The total life cycle cost for EDA IV is about $21.7 billion which equates to a $11.3 billion net present value (both figures rounded up). (2) The incidence of design basis events for EDA IV is similar to the VA reference design. (3) The emplacement of the waste packages in drifts will be similar to the VA reference design. However, heavier equipment may be required because the shielded waste package will be heavier. (4) The heavier

A COMPARATIVE CLINICAL STUDY BETWEEN IV ESMOLOL AND IV FENTANYL ON ATTENUATION OF HAEMODYNAMIC RESPONSES TO LARYNGOSCOPY AND INTUBATION

Directory of Open Access Journals (Sweden)

Abu Lais Mustaque

2016-04-01

Full Text Available INTRODUCTION Laryngoscopy and intubation is an integral part for providing general anaesthesia to patients undergoing various types of surgery. It also plays an important role in critical care units viz. for providing mechanical ventilation. It is a very essential tool in the hands of anaesthesiologist in maintaining airway. The present study is undertaken to determine and compare the efficacy of single bolus dose of IV esmolol 1 mg/kg and IV fentanyl 2 mcg/kg in attenuating the haemodynamic responses to laryngoscopy and tracheal intubation and to ascertain the effectiveness of esmolol hydrochloride and fentanyl citrate in suppressing sympathetic responses. MATERIAL & METHODS The study was conducted under the Department of Anaesthesiology and Critical Care, Assam Medical College and Hospital, Dibrugarh, during the period July 2013 to June 2014. For this purpose, 150 patients of either sex between 20-50 years of ASA I & II physical status were selected after obtaining informed and written consent and were divided into two groups namely, Group E receiving IV esmolol (1 mg/kg and Group F receiving IV fentanyl (2 mcg/kg. RESULTS Inj. fentanyl 2 mcg/kg IV administered 5 minutes before laryngoscopy and intubation was able to prevent adverse haemodynamic changes better than Inj. esmolol 1 mg/kg IV administered 3 minutes prior to laryngoscopy and intubation during elective surgeries under general anaesthesia. CONCLUSION Hence, from the findings of this study we can conclude that IV bolus dose of fentanyl 2 mcg/kg administered 5 minutes before laryngoscopy and intubation can attenuate the sympathetic response to laryngoscopy and intubation without any side effects of the drug in healthy patients undergoing elective surgeries under general anaesthesia.

Ruthenium(ii)-polypyridyl zirconium(iv) metal-organic frameworks as a new class of sensitized solar cells.

Science.gov (United States)

Maza, W A; Haring, A J; Ahrenholtz, S R; Epley, C C; Lin, S Y; Morris, A J

2016-01-01

A series of Ru(ii)L 2 L' (L = 2,2'-bipyridyl, L' = 2,2'-bipyridine-5,5'-dicarboxylic acid), RuDCBPY, -containing zirconium(iv) coordination polymer thin films have been prepared as sensitizing materials for solar cell applications. These metal-organic framework (MOF) sensitized solar cells, MOFSCs, each are shown to generate photocurrent in response to simulated 1 sun illumination. Emission lifetime measurements indicate the excited state quenching of RuDCBPY at the MOF-TiO 2 interface is extremely efficient (>90%), presumably due to electron injection into TiO 2 . A mechanism is proposed in which RuDCBPY-centers photo-excited within the MOF-bulk undergo isotropic energy migration up to 25 nm from the point of origin. This work represents the first example in which a MOFSC is directly compared to the constituent dye adsorbed on TiO 2 (DSC). Importantly, the MOFSCs outperformed their RuDCBPY-TiO 2 DSC counterpart under the conditions used here and, thus, are solidified as promising solar cell platforms.

The BEAST II Experiment at Belle II. Characterization of the commissioning detector system for SuperKEKB

Energy Technology Data Exchange (ETDEWEB)

Ahlburg, Patrick; Eyring, Andreas; Filimonov, Viacheslav; Krueger, Hans; Mari, Laura; Marinas, Carlos; Pohl, David-Leon; Wermes, Norbert; Dingfelder, Jochen [University of Bonn (Germany)

2016-07-01

Before the upgraded vertex detector for the Belle II experiment at the SuperKEKB collider in Japan will be installed, a dedicated detector system for machine commissioning (BEAST II) will be employed. One of its main objectives is to measure and characterize the different background types in order to ensure a safe environment before the installation of the actual silicon detector systems close to the interaction point. FANGS, a detector system at BEAST II, based on ATLAS-IBL front-end electronics and planar silicon sensors is currently being developed for this purpose. The unique feature of this detector system is the high energy resolution achieved by using an external FPGA clock to sample the time-over-threshold signal, while keeping the excellent timing properties. The complete detector system is presented in this talk.

Study of the oxidation-reduction kinetics involved in the Np(V) + Fe(II) in equilibrium Np(IV) + Fe(III) system in nitric acid solutions

International Nuclear Information System (INIS)

Jao, Y.

1975-08-01

Ferrous nitrate-hydrazine is one of the more attractive alternate reactants to the currently used reagent, ferrous sulfamate, for partitioning plutonium from neptunium and uranium. An understanding of the kinetics of the reduction of Np(VI) to Np(IV) by ferrous nitrate-hydrazine is needed before a satisfactory evaluation of the feasibility of this reductant in actinide element separations can be made. The purpose of this work was to study the kinetics and mechanisms of the reduction of Np(V) by Fe(II) and the oxidation of Np(IV) by Fe(III) in 1-2 M nitric acid solutions. The acid concentration range was chosen to include that typically used in the separation of plutonium from neptunium and uranium by solvent extraction with tributylphosphate. The forward and reverse rate constants, hydrogen ion dependence, temperature dependence, ionic strength effects and nitrate ion influence were determined. The proposed reaction mechanisms involve protonation of the NpO 2 + ions and hydroxyoxygenation of Np 4 + ions. (LK)

Sorption and reduction of selenite on chlorite surfaces in the presence of Fe(II) ions.

Science.gov (United States)

Baik, Min Hoon; Lee, Seung Yeop; Jeong, Jongtae

2013-12-01

The sorption and reduction of selenite on chlorite surfaces in the presence of Fe(II) ions were investigated as a function of pH, Se(IV) concentration, and Fe(II) concentration under an anoxic condition. The sorption of Se(IV) onto chlorite surfaces followed the Langmuir isotherm regardless of the presence of Fe(II) ions in the solution. The Se(IV) sorption was observed to be very low at all pH values when the solution was Fe(II)-free or the concentration of Fe(II) ions was as low as 0.5 mg/L. However, the Se(IV) sorption was enhanced at a pH > 6.5 when the Fe(II) concentration was higher than 5 mg/L because of the increased sorption of Fe(II) onto the chlorite surfaces. XANES (X-ray absorption near edge structure) spectra of the Se K-edge showed that most of the sorbed Se(IV) was reduced to Se(0) by Fe(II) sorbed onto the chlorite surfaces, especially at pH > 9. The combined results of field-emission scanning electron microscopy (FE-SEM) and X-ray diffraction (XRD) also showed that elemental selenium and goethite were formed and precipitated on the chlorite surfaces during the sorption of selenite. Consequently it can be concluded that Se(IV) can be reduced to Se(0) in the presence of Fe(II) ions by the surface catalytic oxidation of Fe(II) into Fe(III) and the formation of goethite at neutral and particularly alkaline conditions. Thus the mobility of selenite in groundwater is expected to be reduced by the presence of a relatively higher concentration of Fe(II) in subsurface environments. Copyright © 2013 Elsevier Ltd. All rights reserved.

Safety and operating experience at EBR-II: lessons for the future

International Nuclear Information System (INIS)

Sackett, J.I.; Golden, G.H.

1981-01-01

EBR-II is a small LMFBR power plant that has performed safely and reliably for 16 years. Much has been learned from operating it to facilitate the design, licensing, and operation of large commercial LMFBR power plants in the US. EBR-II has been found relatively easy to keep in conformity with evolving safety requirements, largely because of inherent safety features of the plant. Such features reduce dependence on active safety systems to protect against accidents. EBR-II has experienced a number of plant-transient incidents, some planned, others inadvertent; none has resulted in any significant plant damage. The operating experience with EBR-II has led to the formulation of an Operational Reliability Test Program (ORTP), aimed at showing inherently safe performance of fuel and plant systems

Status of neutrino mass experiments

International Nuclear Information System (INIS)

Fackler, O.

1985-01-01

In 1980 two experiments ignited a fertile field of research - the determination of the neutrino masses. Subsequently, over 35 experiments using a variety of techniques have probed or are probing this question. Primarily the author discuss electron antineutrino (hereafter referred to as neutrino) mass experiments. Section I begins with a discussion of astronomical and terrestrial observations which motivated these experiments. In Section II, the author quote limits from muon and tau mass determinations. These limits are more thoroughly discussed in other paper. The author continues by describing the four approaches used to measure the electron neutrino mass. In Section III, tritium beta decay mass determinations are reviewed. This section includes a general summary of previous experimental results, and discussion of the major ongoing experiments. Section IV offers concluding remarks

Hepatic imaging in stage IV-S neuroblastoma

International Nuclear Information System (INIS)

Franken, E.A. Jr.; Smith, W.L.; Iowa Univ., Iowa City; Cohen, M.D.; Kisker, C.T.; Platz, C.E.

1986-01-01

Stage IV-S neuroblastoma describes a group of infants with tumor spread limited to liver, skin, or bone marrow. Such patients, who constitute about 25% of affected infants with neuroblastoma, may expect spontaneous tumor remission. We report 18 infants with Stage IV-S neuroblastoma, 83% of whom had liver involvement. Imaging investigations included Technetium 99m sulfur colloid scan, ultrasound, and CT. Two patterns of liver metastasis were noted: ill-defined nodules or diffuse tumor throughout the liver. Distinction of normal and abnormal liver with diffuse type metastasis could be quite difficult, particularly with liver scans. We conclude that patients with Stage IV-S neuroblastoma have ultrasound or CT examination as an initial workup, with nuclear medicine scans reserved for followup studies. (orig.)

Reduction and long-term immobilization of technetium by Fe(II) associated with clay mineral nontronite

International Nuclear Information System (INIS)

Jaisi, Deb P.; Dong, Hailiang; Plymale, Andrew E.; Fredrickson, Jim K.; Zachara, John M.; Heald, S.; Liu, Chongxuan

2009-01-01

99Tc is formed mostly during nuclear reactions and is released into the environment during weapons testing and inadvertent waste disposal. The long half-life, high environmental mobility (as Tc(VII)O4-) and its possible uptake into the food chain cause 99Tc to be a significant environmental contaminant. In this study, we evaluated the role of Fe(II) in biologically reduced clay mineral, nontronite (NAu-2), in reducing Tc(VII)O4- to poorly soluble Tc(IV) species as a function of pH and Fe(II) concentration. The rate of Tc(VII) reduction by Fe(II) in NAu-2 was higher at neutral pH (pH 7.0) than at acidic and basic pHs when Fe(II) concentration was low (< 1 mmol/g). The effect of pH, however, was insignificant at higher Fe(II) concentrations. The reduction of Tc(VII) by Fe(II) associated with NAu-2 was also studied in the presence of common subsurface oxidants including iron and manganese oxides, nitrate, and oxygen, to evaluate the effect of the oxidants on the enhancement and inhibition of Tc(VII) reduction, and reoxidation of Tc(IV). Addition of iron oxides (goethite and hematite) to the Tc(VII)-NAu-2 system, where Tc(VII) reduction was ongoing, enhanced reduction of Tc(VII), apparently as a result of re-distribution of reactive Fe(II) from NAu-2 to more reactive goethite/hematite surfaces. Addition of manganese oxides stopped further Tc(VII) reduction, and in case of K+-birnessite, it reoxidized previously reduced Tc(IV). Nitrate neither enhanced reduction of Tc(VII) nor promoted reoxidation of Tc(IV). Approximately 11% of Tc(IV) was oxidized by oxygen. The rate and extent of Tc(IV) reoxidation was found to strongly depend on the nature of the oxidants and concentration of Fe(II). When the same oxidants were added to aged Tc reduction products (mainly NAu-2 and TcO2nH2O), the extent of Tc(IV) reoxidation decreased significantly relative to fresh Tc(IV) products. Increasing NAu-2 concentration also resulted in the decreased extent of Tc(IV) reoxidation. The results

Thermodynamic data for predicting concentrations of Th(IV), U(IV), Np(IV), and Pu(IV) in geologic environments

Energy Technology Data Exchange (ETDEWEB)

Rai, Dhanpat; Roa, Linfeng; Weger, H.T.; Felmy, A.R. [Battelle, Pacific Northwest National Laboratory (PNNL) (United States); Choppin, G.R. [Florida State University (United States); Yui, Mikazu [Waste Isolation Research Division, Tokai Works, Japan Nuclear Cycle Development Inst., Tokai, Ibaraki (Japan)

1999-01-01

This report provides thermodynamic data for predicting concentrations of Th(IV), U(IV), Np(IV), and Pu(IV) in geologic environments, and contributes to an integration of the JNC chemical thermodynamic database, JNC-TDB (previously PNC-TDB), for the performance analysis of geological isolation system for high-level radioactive wastes. Thermodynamic data for the formation of complexes or compounds with hydroxide, chloride, fluoride, carbonate, nitrate, sulfate and phosphate are discussed in this report. Where data for specific actinide(IV) species was lacking, the data were selected based on chemical analogy to other tetravalent actinides. In this study, the Pitzer ion-interaction model is used to extrapolate thermodynamic constants to zero ionic strength at 25degC. (author)

Synthesis and characterization of poly-o-anisidine Sn(IV tungstate: A new and novel ‘organic–inorganic’ nano-composite material and its electro-analytical applications as Hg(II ion-selective membrane electrode

Directory of Open Access Journals (Sweden)

Asif A. Khan

2012-07-01

Full Text Available An organic–inorganic nano-composite poly-o-anisidine Sn(IV tungstate was chemically synthesized by sol–gel mixing of the incorporation of organic polymer o-anisidine into the matrices of inorganic ppt of Sn(IV tungstate in different mixing volume ratios. This composite material has been characterized using various analytical techniques like XRD (X-ray diffraction, FTIR (Fourier transform infrared, SEM (Scanning electron microscopy, TEM (Transmission electron microscopy and simultaneous TGA (Thermogravimetric analysis studies. On the basis of distribution studies, the material was found to be highly selective for Hg(II. Using this nano-composite cation exchanger as electro-active material, a new heterogeneous precipitate based on ion-sensitive membrane electrode was developed for the determination of Hg(II ions in solutions. The membrane electrode was mechanically stable, with a quick response time, and can be operated within a wide pH range. The electrode was also found to be satisfactory in electrometric titrations.

Development of alternate paragraphs for the Logical Memory subtest of the Wechsler Memory Scale-IV.

Science.gov (United States)

Morris, Jeri; Swier-Vosnos, Amy; Woodworth, Craig; Umfleet, Laura Glass; Czipri, Sheena; Kopald, Brandon

2014-01-01

The purpose of the two studies included in this article was to validate an alternate form, the Morris Revision-Fourth Edition (MR-IV), to the Logical Memory paragraphs of the Wechsler Memory Scale-Fourth Edition (LM-IV) for use when retesting of individuals is desired. Study I demonstrated high correlation with the LM-IV paragraphs. Study II was a replication that again demonstrated high correlation between the original LM-IV and the new MR-IV paragraphs. High interrater reliability also was demonstrated. Consequently, the MR-IV paragraphs can be considered an alternate form to the LM-IV paragraphs. Although other attempts have been made to develop alternate stories, these new paragraphs are the only ones that are equivalent in structure, affective tone, and number of scorable units. They have considerable clinical utility and research potential.

Lithium beam characterization of cylindrical PBFA II hohlraum experiments

International Nuclear Information System (INIS)

Moats, A.R.; Derzon, M.S.; Chandler, G.A.; Haill, T.A.; Johnson, D.J.; Leeper, R.J.; Ruiz, C.L.; Wenger, D.F.

1995-01-01

Sandia National Laboratories is actively engaged in exploring indirect-drive inertial confinement fusion on the Particle Beam Fusion Accelerator (PBFA II) with pulsed-power accelerated lithium ions as the driver. Experiments utilizing cylindrical hohlraum targets were conducted in 1994. Using the incoming ion beam-induced line radiation from titanium wires surrounding these hohlraums, beam profiles during these experiments have been measured and characterized. These data, their comparison/cross-correlation with particle-based beam diagnostics, and an analysis of the beam parameters that most significantly influence target temperature are presented

Seventeen years of LMFBR experience: Experimental Breeder Reactor II (EBR-II)

International Nuclear Information System (INIS)

Perry, W.H.; Lentz, G.L.; Richardson, W.J.; Wolz, G.C.

1982-01-01

Operating experience at EBR-II over the past 17 years has shown that a sodium-cooled pool-type reactor can be safely and efficiently operated and maintained. The reactor has performed predictably and benignly during normal operation and during both unplanned and planned plant upsets. The duplex-tube evaporators and superheaters have never experienced a sodium/water leak, and the rest of the steam-generating system has operated without incident. There has been no noticeable degradation of the heat transfer efficiency of the evaporators and superheaters, except for the one superheater replaced in 1981. There has been no need to perform any chemical cleaning of steam-system components

Influence of NO2 and metal ions on oxidation of aqueous-phase S(IV in atmospheric concentrations

Directory of Open Access Journals (Sweden)

Cláudia R. Martins

2008-06-01

Full Text Available An investigation was made of the influence of atmospheric concentrations (15 or 130 ppbv of NO2 on the aqueous-phase oxidation rate of S(IV in the presence and absence of Fe(III, Mn(II and Cr(VI metal ions under controlled experimental conditions (pH, T, concentration of reactants, etc.. The reaction rate in the presence of the NO2 flow was slower than the reaction rate using only clean air with an initial S(IV concentration of 10-4 mol/L. NO2 appears to react with S(IV, producing a kind of inhibitor that slows down the reaction. Conversely, tenfold lower concentrations of S(IV ([S(IV]º = 10-5 mol/L caused a faster reaction in the presence of NO2 than the reaction using purified air. Under these conditions, therefore, the equilibrium shifts to sulfate formation. With the addition of Fe(III, Mn(II or Cr(VI in the presence of a NO2 flow, the reaction occurred faster under all the conditions in which S(IV oxidation was investigated.A reação de oxidação de S(IV em fase aquosa foi estudada em laboratório em presença de NO2 dos íons metálicos Fe(III, Mn(II, e Cr(VI sob condições experimentais controladas (pH, T, concentração dos reagentes, etc.. Na presença de corrente de ar com NO2 (15 ou 130 ppbv a reação de oxidação de S(IV ocorreu mais lentamente do que na presença de ar purificado, para uma concentração inicial de S(IV de 10-4 mol/L. Ao contrário, para concentração inicial de S(IV dez vezes menor ([S(IV]° = 10-5 mol/L a reação ocorreu mais rapidamente na presença de NO2. A explicação está relacionada com o equilíbrio envolvendo a formação de espécies intermediárias de longa vida, que impedem o prosseguimento da reação, porém a depender das concentrações relativas de S(IV e NO2, essas espécies se decompõem deslocando o equilíbrio no sentido de formação de sulfato. A adição dos íons Fe(III, Mn(II ou Cr(VI em presença de corrente de ar com NO2 indicou atividade catalítica para esses íons, em todas

About the structure and stability of complex carbonates of thorium (IV), cerium (IV), zirconium (IV), hafnium (IV)

International Nuclear Information System (INIS)

Dervin, Jacqueline

1972-01-01

This research thesis addressed the study of complex carbonates of cations of metals belonging to the IV A column, i.e. thorium (IV), zirconium (IV), hafnium (IV), and also cerium (IV) and uranium (VI), and more particularly focused on ionic compounds formed in solution, and also on the influence of concentration and nature of cations on stability and nature of the formed solid. The author first presents methods used in this study, discusses their precision and scope of validity. She reports the study of the formation of different complex ions which have been highlighted in solution, and the determination of their formation constants. She reports the preparation and study of the stability domain of solid complexes. The next part reports the use of thermogravimetric analysis, IR spectrometry, and crystallography for the structural study of these compounds

Experience with lifetime limits for EBR-II core components

International Nuclear Information System (INIS)

Lambert, J.D.B.; Smith, R.N.; Golden, G.H.

1987-01-01

The Experimental Breeder Reactor No. 2 (EBR-II) is operated for the US Department of Energy by Argonne National Laboratory and is located on the Idaho National Engineering Laboratory where most types of American reactor were originally tested. EBR-II is a complete electricity-producing power plant now in its twenty-fourth year of successful operation. During this long history the reactor has had several concurrent missions, such as demonstration of a closed Liquid-Metal Reactor (LMR) fuel cycle (1964-69); as a steady-state irradiation facility for fuels and materials (1970 onwards); for investigating effects of operational transients on fuel elements (from 1981); for research into the inherent safety aspects of metal-fueled LMR's (from 1983); and, most recently, for demonstration of the Integral Fast Reactor (IFR) concept using U-Pu-Zr fuels. This paper describes experience gained at EBR-II in defining lifetime limits for LMR core components, particularly fuel elements

Burn-up TRIGA Mark II benchmark experiment

International Nuclear Information System (INIS)

Persic, A.; Ravnik, M.; Zagar, T.

1998-01-01

Different reactor codes are used for calculations of reactor parameters. The accuracy of the programs is tested through comparison of the calculated values with the experimental results. Well-defined and accurately measured benchmarks are required. The experimental results of reactivity measurements, fuel element reactivity worth distribution and fuel-up measurements are presented in this paper. The experiments were performed with partly burnt reactor core. The experimental conditions were well defined, so that the results can be used as a burn-up benchmark test case for a TRIGA Mark II reactor calculations.(author)

Fuel element failure detection experiments, evaluation of the experiments at KNK II/1 (Intermediate Report)

CERN Document Server

Bruetsch, D

1983-01-01

In the frame of the fuel element failure detection experiments at KNK II with its first core the measurement devices of INTERATOM were taken into operation in August 1981 and were in operation almost continuously. Since the start-up until the end of the first KNK II core operation plugs with different fuel test areas were inserted in order to test the efficiency of the different measuring devices. The experimental results determined during this test phase and the gained experiences are described in this report and valuated. All three measuring techniques (Xenon adsorption line XAS, gas-chromatograph GC and precipitator PIT) could fulfil the expectations concerning their susceptibility. For XAS and GC the nuclide specific sensitivities as determined during the preliminary tests could be confirmed. For PIT the influences of different parameters on the signal yield could be determined. The sensitivity of the device could not be measured due to a missing reference measuring point.

TOP counter for particle identification at the Belle II experiment

Energy Technology Data Exchange (ETDEWEB)

Inami, Kenji

2014-12-01

Ring imaging Cherenkov counter, named TOP counter, utilizing precise photon detection timing has been developed as a particle identification detector for the Belle II experiment. The real size prototype has been produced and tested with 2 GeV positrons at Spring-8 LEPS beam line. The quartz radiator production and assembling with microchannel plate photomultipliers was successfully carried out. The beam test data shows good agreement with full Monte-Carlo simulation results in the ring image and the distribution of number of detected photons and timing information. - Highlights: • TOP counter was developed as a particle identification detector for the Belle II experiment. • The real size prototype was produced and tested with 2 GeV positrons. • The quartz radiator production and assembling with MCP-PMT was successfully carried out. • The beam test data shows good agreement with full Monte-Carlo simulation results.

[Diagnostic values of serum type III procollagen N-terminal peptide in type IV gastric cancer].

Science.gov (United States)

Akazawa, S; Fujiki, T; Kanda, Y; Kumai, R; Yoshida, S

1985-04-01

Since increased synthesis of collagen has been demonstrated in tissue of type IV gastric cancer, we attempted to distinguish type IV gastric cancer from other cancers by measuring serum levels of type III procollagen N-terminal peptide (type III-N-peptide). Mean serum levels in type IV gastric cancer patients without metastasis were found to be elevated above normal values and developed a tendency to be higher than those in types I, II and III gastric cancer patients without metastasis. Highly positive ratios were found in patients with liver diseases including hepatoma and colon cancer, biliary tract cancer, and esophageal cancer patients with liver, lung or bone metastasis, but only 2 out of 14 of these cancer patients without such metastasis showed positive serum levels of type III-N-peptide. Positive cases in patients with type IV gastric cancer were obtained not only in the group with clinical stage IV but also in the groups with clinical stages II and III. In addition, high serum levels of type III-N-peptide in patients with type IV gastric cancer were seen not only in the cases with liver, lung or bone metastasis but also in cases with disseminated peritoneal metastasis alone. These results suggest that if the serum level of type III-N-peptide is elevated above normal values, type IV gastric cancer should be suspected after ruling out liver diseases, myelofibrosis and liver, lung or bone metastasis.

Experiments with the HORUS-II test facility

Energy Technology Data Exchange (ETDEWEB)

Alt, S.; Lischke, W. [Univ. for Applied Sciences Zittau/Goerlitz, Zittau (Germany). Dept. of Nuclear Engineering

1997-12-31

Within the scope of the German reactor safety research the thermohydraulic computer code ATHLET which was developed for accident analyses of western nuclear power plants is more and more used for the accident analysis of VVER-plants particularly for VVER-440,V-213. The experiments with the HORUS-facilities and the analyses with the ATHLET-code have been realized at the Technical University Zittau/Goerlitz since 1991. The aim of the investigations was to improve and verify the condensation model particularly the correlations for the calculation of the heat transfer coefficients in the ATHLET-code for pure steam and steam-noncondensing gas mixtures in horizontal tubes. About 130 condensation experiments have been performed at the HORUS-II facility. The experiments have been carried out with pure steam as well as with noncondensing gas injections into the steam mass flow. The experimental simulations are characterized as accident simulation tests for SBLOCA for VVER-conditions. The simulation conditions had been adjusted correspondingly to the parameters of a postulated SBLOCA`s fourth phase at the original plant. 4 refs.

Experiments with the HORUS-II test facility

Energy Technology Data Exchange (ETDEWEB)

Alt, S; Lischke, W [Univ. for Applied Sciences Zittau/Goerlitz, Zittau (Germany). Dept. of Nuclear Engineering

1998-12-31

Within the scope of the German reactor safety research the thermohydraulic computer code ATHLET which was developed for accident analyses of western nuclear power plants is more and more used for the accident analysis of VVER-plants particularly for VVER-440,V-213. The experiments with the HORUS-facilities and the analyses with the ATHLET-code have been realized at the Technical University Zittau/Goerlitz since 1991. The aim of the investigations was to improve and verify the condensation model particularly the correlations for the calculation of the heat transfer coefficients in the ATHLET-code for pure steam and steam-noncondensing gas mixtures in horizontal tubes. About 130 condensation experiments have been performed at the HORUS-II facility. The experiments have been carried out with pure steam as well as with noncondensing gas injections into the steam mass flow. The experimental simulations are characterized as accident simulation tests for SBLOCA for VVER-conditions. The simulation conditions had been adjusted correspondingly to the parameters of a postulated SBLOCA`s fourth phase at the original plant. 4 refs.

Experiments with the HORUS-II test facility

International Nuclear Information System (INIS)

Alt, S.; Lischke, W.

1997-01-01

Within the scope of the German reactor safety research the thermohydraulic computer code ATHLET which was developed for accident analyses of western nuclear power plants is more and more used for the accident analysis of VVER-plants particularly for VVER-440,V-213. The experiments with the HORUS-facilities and the analyses with the ATHLET-code have been realized at the Technical University Zittau/Goerlitz since 1991. The aim of the investigations was to improve and verify the condensation model particularly the correlations for the calculation of the heat transfer coefficients in the ATHLET-code for pure steam and steam-noncondensing gas mixtures in horizontal tubes. About 130 condensation experiments have been performed at the HORUS-II facility. The experiments have been carried out with pure steam as well as with noncondensing gas injections into the steam mass flow. The experimental simulations are characterized as accident simulation tests for SBLOCA for VVER-conditions. The simulation conditions had been adjusted correspondingly to the parameters of a postulated SBLOCA's fourth phase at the original plant

Two-stage precipitation of neptunium (IV) oxalate

International Nuclear Information System (INIS)

Luerkens, D.W.

1983-07-01

Neptunium (IV) oxalate was precipitated using a two-stage precipitation system. A series of precipitation experiments was used to identify the significant process variables affecting precipitate characteristics. Process variables tested were input concentrations, solubility conditions in the first stage precipitator, precipitation temperatures, and residence time in the first stage precipitator. A procedure has been demonstrated that produces neptunium (IV) oxalate particles that filter well and readily calcine to the oxide

X-Band Electron Paramagnetic Resonance Comparison of Mononuclear Mn(IV)-oxo and Mn(IV)-hydroxo Complexes and Quantum Chemical Investigation of Mn(IV) Zero-Field Splitting.

Science.gov (United States)

Leto, Domenick F; Massie, Allyssa A; Colmer, Hannah E; Jackson, Timothy A

2016-04-04

X-band electron paramagnetic resonance (EPR) spectroscopy was used to probe the ground-state electronic structures of mononuclear Mn(IV) complexes [Mn(IV)(OH)2(Me2EBC)](2+) and [Mn(IV)(O)(OH)(Me2EBC)](+). These compounds are known to effect C-H bond oxidation reactions by a hydrogen-atom transfer mechanism. They provide an ideal system for comparing Mn(IV)-hydroxo versus Mn(IV)-oxo motifs, as they differ by only a proton. Simulations of 5 K EPR data, along with analysis of variable-temperature EPR signal intensities, allowed for the estimation of ground-state zero-field splitting (ZFS) and (55)Mn hyperfine parameters for both complexes. From this analysis, it was concluded that the Mn(IV)-oxo complex [Mn(IV)(O)(OH)(Me2EBC)](+) has an axial ZFS parameter D (D = +1.2(0.4) cm(-1)) and rhombicity (E/D = 0.22(1)) perturbed relative to the Mn(IV)-hydroxo analogue [Mn(IV)(OH)2(Me2EBC)](2+) (|D| = 0.75(0.25) cm(-1); E/D = 0.15(2)), although the complexes have similar (55)Mn values (a = 7.7 and 7.5 mT, respectively). The ZFS parameters for [Mn(IV)(OH)2(Me2EBC)](2+) were compared with values obtained previously through variable-temperature, variable-field magnetic circular dichroism (VTVH MCD) experiments. While the VTVH MCD analysis can provide a reasonable estimate of the magnitude of D, the E/D values were poorly defined. Using the ZFS parameters reported for these complexes and five other mononuclear Mn(IV) complexes, we employed coupled-perturbed density functional theory (CP-DFT) and complete active space self-consistent field (CASSCF) calculations with second-order n-electron valence-state perturbation theory (NEVPT2) correction, to compare the ability of these two quantum chemical methods for reproducing experimental ZFS parameters for Mn(IV) centers. The CP-DFT approach was found to provide reasonably acceptable values for D, whereas the CASSCF/NEVPT2 method fared worse, considerably overestimating the magnitude of D in several cases. Both methods were poor in

Conditions Database for the Belle II Experiment

Science.gov (United States)

Wood, L.; Elsethagen, T.; Schram, M.; Stephan, E.

2017-10-01

The Belle II experiment at KEK is preparing for first collisions in 2017. Processing the large amounts of data that will be produced will require conditions data to be readily available to systems worldwide in a fast and efficient manner that is straightforward for both the user and maintainer. The Belle II conditions database was designed with a straightforward goal: make it as easily maintainable as possible. To this end, HEP-specific software tools were avoided as much as possible and industry standard tools used instead. HTTP REST services were selected as the application interface, which provide a high-level interface to users through the use of standard libraries such as curl. The application interface itself is written in Java and runs in an embedded Payara-Micro Java EE application server. Scalability at the application interface is provided by use of Hazelcast, an open source In-Memory Data Grid (IMDG) providing distributed in-memory computing and supporting the creation and clustering of new application interface instances as demand increases. The IMDG provides fast and efficient access to conditions data via in-memory caching.

Serum insulin-like growth factor II (IGF-II) in chronic heart failure

International Nuclear Information System (INIS)

Tong Lijun; Chen Donghai; Ji Naijun; Fan Bifu; Wang Chengyao; Mei Yibin; Li Fuyuan; Kao Yan

2004-01-01

Objective: To investigate the clinical significance of changes of serum insulin-like growth factor II (IGF-II) levels in patients with chronic heart failure. Methods: Serum IGF-II levels were measured with RIA in 132 cases of chronic heart failure and 45 controls. Results: Serum IGF-II levels were significantly higher in patients with chronic heart failure than those in the controls (t=0.033, P<0.001). IGF-II levels were highest in grade IV CHF patients (vs grade II t=3.963, P<0.01; vs grade III, t=3.578, P<0.01). In the twelve patients died in hospital, the serum IGF-II levels were significantly higher than those patients recovered (t=7.141, P<0.01). Conclusion: Serum IGF-II levels were increased in CHF patients and were highest in the most severe cases. (authors)

Status of neutrino mass experiments

International Nuclear Information System (INIS)

Fackler, O.

1985-12-01

In 1980 two experiments ignited a fertile field of research the determination of the neutrino masses. Subsequently, over 35 experiments using a variety of techniques have probed or are probing this question. Primarily I will discuss electron antineutrino (hereafter referred to as neutrino) mass experiments. However, let me begin in Section I to discuss astronomical and terrestrial observations which motivated these experiments. In Section II, I will quote limits from muon and tau mass determinations. These limits are more thoroughly discussed in other papers. I will continue by describing the four approaches used to measure the electron neutrino mass. In Section III, tritium beta decay mass determinations will be reviewed. This section includes a general summary of previous experimental results, and discussion of the major ongoing experiments. Section IV offers concluding remarks. 24 refs., 24 figs

Dipeptidyl-peptidase IV (DPP-IV) inhibitor delays tolerance to anxiolytic effect of ethanol and withdrawal-induced anxiety in rats.

Science.gov (United States)

Sharma, Ajaykumar N; Pise, Ashish; Sharma, Jay N; Shukla, Praveen

2015-06-01

Dipeptidyl-peptidase IV (DPP-IV) is an enzyme responsible for the metabolism of endogenous gut-derived hormone, glucagon-like peptide-1 (GLP-1). DPP-IV is known for its role in energy homeostasis and pharmacological blockade of this enzyme is a recently approved clinical strategy for the management of type II diabetes. Accumulating evidences suggest that enzyme DPP-IV can affect spectrum of central nervous system (CNS) functions. However, little is known about the role of this enzyme in ethanol-mediated neurobehavioral complications. The objective of the present study was to examine the impact of DPP-IV inhibitor, sitagliptin on the development of tolerance to anxiolytic effect of ethanol and anxiety associated with ethanol withdrawal in rats. A dose-response study revealed that sitaglitpin (20 mg/kg, p.o.) per se exhibit anxiolytic effect in the elevated plus maze (EPM) test in rats. Tolerance to anxiolytic effect of ethanol (2 g/kg, i.p.; 8 % w/v) was observed from 7(th) day of ethanol-diet (6 % v/v) consumption. In contrast, tolerance to anxiolytic effect of ethanol was delayed in rats that were treated daily with sitagliptin (20 mg/kg, p.o.) as tolerance was observed from 13(th)day since commencement of ethanol-diet consumption. Discontinuation of rats from ethanol-diet after 15-days of ethanol consumption resulted in withdrawal anxiety between 8 h and 12 h post-abstinence. However, rats on 15-day ethanol-diet with concomitant sitagliptin (20 mg/kg, p.o.) treatment exhibited delay in appearance (24 h post-withdrawal) of withdrawal anxiety. In summary, DPP-IV inhibitors may prove as an attractive research strategy against ethanol tolerance and dependence.

Directed synthesis of crystalline plutonium (III) and (IV) oxalates: accessing redox-controlled separations in acidic solutions

International Nuclear Information System (INIS)

Runde, Wolfgang; Brodnax, Lia F.; Goff, George S.; Bean, Amanda C.; Scott, Brian L.

2009-01-01

Both binary and ternary solid complexes of Pu(III) and Pu(IV) oxalates have been previously reported in the literature. However, uncertainties regarding the coordination chemistry and the extent of hydration of some compounds remain mainly because of the absence of any crystallographic characterization. Single crystals of hydrated oxalates of Pu(III), Pu 2 (C 2 O 4 ) 3 (H 2 O) 6 ·3H 2 O (I) and Pu(IV), KPu(C 2 O 4 ) 2 (OH)·2.5H 2 O (II), were synthesized under moderate hydrothermal conditions and characterized by single crystal X-ray diffraction studies. Compounds I and II are the first plutonium(III) or (IV) oxalate compounds to be structurally characterized via single crystal X-ray diffraction studies. Crystallographic data for I: monoclinic, space group P21/c, a = 11.246(3) A, b = 9.610(3) A, c = 10.315(3) A, Z = 4 and II: monoclinic, space group C2/c, a = 23.234(14) A, b = 7.502(4) A, c = 13.029(7) A, Z = 8.

Improvement of Steam Generator Reliability for GEN-IV SFR

Energy Technology Data Exchange (ETDEWEB)

Kim, Seong O; Kim Se Yun; Kim, Seok Hoon; Eoh, Jae Hyuk; Lee, Hyeong Yeon; Choi, Byung Seon

2005-11-15

The R and D items performed in this study were selected from the R and D task of ' Reliability improvement of Steam Generator' of GEN-IV SFR Component Design and BOP. Since this project deals with one of the most important issues for a GEN-IV SFR system, it needs to enhance the domestic technical backgrounds associated with the corresponding R and D items even for a very short period by 2005. This study provides the R and D results for i) Development of assessment methodology for dissimilar metal weld and ii) Development of multi-dimensional simulation methodology for a SWR event in a SFR steam generator.

Improvement of Steam Generator Reliability for GEN-IV SFR

International Nuclear Information System (INIS)

Kim, Seong O; Kim Se Yun; Kim, Seok Hoon; Eoh, Jae Hyuk; Lee, Hyeong Yeon; Choi, Byung Seon

2005-11-01

The R and D items performed in this study were selected from the R and D task of ' Reliability improvement of Steam Generator' of GEN-IV SFR Component Design and BOP. Since this project deals with one of the most important issues for a GEN-IV SFR system, it needs to enhance the domestic technical backgrounds associated with the corresponding R and D items even for a very short period by 2005. This study provides the R and D results for i) Development of assessment methodology for dissimilar metal weld and ii) Development of multi-dimensional simulation methodology for a SWR event in a SFR steam generator

ETA-II experiments for determining advanced radiographic capabilities of induction linacs

International Nuclear Information System (INIS)

Weir, J.T.; Caporaso, G.J.; Clark, J.C.; Kirbie, H.C.; Chen, Y.J.; Lund, S.M.; Westenskow, G.A.; Paul, A.C.

1997-05-01

LLNL has proposed a multi-pulsed, multi-line of sight radiographic machine based on induction linac technology to be the core of the advanced hydrotest facility (AHF) being considered by the Department of Energy. In order to test the new technologies being developed for AHF we have recommissioned the Experimental Test Accelerator (ETA II). We will conduct our initial experiments using kickers and large angle bending optics at the ETA II facility. Our current status and our proposed experimental schedule will be presented

Analysis of benchmark experiments for testing the IKE multigroup cross-section libraries based on ENDF/B-III and IV

International Nuclear Information System (INIS)

Keinert, J.; Mattes, M.

1975-01-01

Benchmark experiments offer the most direct method for validation of nuclear cross-section sets and calculational methods. For 16 fast and thermal critical assemblies containing uranium and/or plutonium of different compositions we compared our calculational results with measured integral quantities, such as ksub(eff), central reaction rate ratios or fast and thermal activation (dis)advantage factors. Cause of the simple calculational modelling of these assemblies the calculations proved as a good test for the IKE multigroup cross-section libraries essentially based on ENDF/B-IV. In general, our calculational results are in excellent agreement with the measured values. Only with some critical systems the basic ENDF/B-IV data proved to be insufficient in calculating ksub(eff), probably due to Pu neutron data and U 238 fast capture cross-sections. (orig.) [de

Analytical recovery of Cr (VI), Mo (VI), Ti (IV) and Co (II) by N-phenyl-meta-nitro-benzohydroxamic and N-P-tolyl-meta-nitro-benzohydroxamic acids

International Nuclear Information System (INIS)

Ahmed, Abdul Aziz Malik Mohamed

2000-05-01

Two hydroxamic acids were prepared; N-phenyl-m-nitro-benzohydroxamic and N-p-tolyl-m-nitro-benzo hydroxamic acids. N-phenyl-m-nitro-benzohydroxamic was prepared by coupling the β-phenyl hydroxylamine with m-nitro-benzoyl chloride in ratio 1:1 in alkaline medium at zero degree centigrade. It recrystallized from a mixture of benzene and petroleum ether (2:1) with the yield of 67%. The product was characterized by: A-nitrogen content which was found to be 10.7% (lit. 10.9%). B-infra-red spectroscopy. C-the molecular weight which was determined by titration, was found to be 257.7 gram (lit. 257 gram). D-the molecular weight which was determined by elevation of the boiling point, was found to be 253.7 gram (lit. 257 gram). E-characteristic violet color reaction with vanadium and blood-red reaction with ferric chloride solutions. F-melting point 117 degree centigrade. N-p-tolyl-m-nitro benzo hydroxamic acid was prepared by coupling the p-tolyl-hydroxylamine with m-nitro benzoyl chloride using the same procedure. It was recrystallized from a mixture of benzene and petroleum ether (2:1) with the yield of 63%. The product was characterized by: A-nitrogen content which was found to be 10.1% (lit. 10.3). B-infra-red spectroscopy. C-the molecular weight which was determined by titration, was found to be 271.6 gram (lit. 272). D-the molecular weight which was determined by elevation of the boiling point, was found to be 269.9 gram (lit. 272 gram). E.characteristic violet color reaction with vanadium and blood-red color with ferric chloride solutions. F-melting point which was found to be 105 degree centigrade (lit. 106 degree c). the two hydroxamic acids were used as analytical reagents for extraction of metal ions Ti (IV), Cr (VI), Mo (VI) and Co (II). With an equal volume of the organic and aqueous phase, and only one extraction, N-phenyl-m-nitro-benzohydroxamic acid was found to have a maximum extraction of 30.18% for Ti (IV) at pH 2.0, of 97.06% for Cr (VI) at 3MH 2 SO 4

Development of compact synchrotron radiation facilities TELL-TERAS, NIJI-I∼IV, at ETL

International Nuclear Information System (INIS)

Tomimasu, T.

1990-01-01

At the Electrotechnical Laboratory (ETL) four compact storage rings, TERAS, NIJI-I∼III, have been already constructed and a compact storage ring, NIJI-IV, with long straight sections for a free electron laser (FEL) experiment will be completed in 1990. The 0.8-GeV ETL storage ring is called TERAS; Tsukuba Electron Ring for Accelerating and Storage. TERAS has been operated since Oct. 1981 for researches on radiometric standards, dissociative photoionization, photodissociation of sulfur containing molecules, solid state physics, ULSI lithography, generation of polarized SR and gamma-rays and for FEL experiment using an transverse optical klystron (TOK). A 10-T three pole wiggler will be installed in 1991 at the straight section where the TOK is installed. NIJI-I is a 0.27-GeV compact ring. NIJI is a Japanese verb meaning 'rainbow' in English. It has been operated from Feb. 1986 to March 1989 for machine study of beam storage higher than 0.5 A at low energies below 0.15-GeV. NIJI-II is a 0.6-GeV conventional type compact ring. It has been operated in Aug. 1989 and will be used for chemical vapor deposition (CVD) and polarized SR experiments. NIJI-III is a 0.62-GeV superconducting type ring. It will be used for ULSI lithography experiments. Before the superconducting coils are installed, NIJI-III with conventional type magnets has been already constructed and operated in June 1989. NIJI-III with the superconducting ones is now operated in June 1990. NIJI-IV is a 0.5-GeV conventional type compact ring with straight sections longer than 7m where a 6.2-m long TOK is installed to achieve UV FEL experiment. (author)

Comparative study of poloidal field systems for the torus II experiment

International Nuclear Information System (INIS)

Farvaque, L.; Ghazal, S.; Leloup, C.; Pariente, M.; CEA Centre d'Etudes Nucleaires de Fontenay-aux-Roses, 92

1976-11-01

Three types of transformer for the TORUS II experiment are compared: a saturated iron core transformer with an entire magnetic circuit, an air core transformer and a saturated iron core transformer restricted to the central limb [fr

IV paracetamol effect on propofol-ketamine consumption in paediatric patients undergoing ESWL.

Science.gov (United States)

Eker, H Evren; Cok, Oya Yalçin; Ergenoğlu, Pınar; Ariboğan, Anış; Arslan, Gülnaz

2012-06-01

Electroshock wave lithotripsy (ESWL) is a painful procedure performed with sedoanalgesia in paediatric patients. The propofol-ketamine combination may be the preferable anaesthesia for this procedure, and propofol-ketamine consumption may be decreased with the administration of intravenous (IV) paracetamol. In this study we investigated the effect of IV paracetamol administration on propofol-ketamine consumption, recovery time and frequency of adverse events in paediatric patients undergoing ESWL. Sixty children, ranging in age from 1 to 10 years and with American Society of Anesthesiologists Physical Status 1-2, were included in this prospective, randomized, double-blinded study. Thirty minutes prior to the procedure children randomly assigned to Group I received IV 15 mg/kg paracetamol, and those randomly assigned to Group II received 1.5 mL/kg IV saline infusion 30 min. The propofol-ketamine combination was prepared by mixing 25 mg propofol and 25 mg ketamine in a total 10 mL solution in the same syringe. After the administration of 0.1 mg/kg midazolam and 10 μg/kg atropine to both groups and during the procedure, the propofol-ketamine combination was administered at 0.5 mg/kg doses to achieve a Wisconsin sedation score of 1 or 2. Oxygen saturation and heart rate were recorded at 5-min intervals. Propofol-ketamine consumption, recovery times and adverse events were also recorded. Demographic data were similar between groups. Propofol-ketamine consumption (Group I, 25.2 ± 17.7 mg; Group II, 35.4 ± 20.1 mg; p = 0.04) and recovery times (Group I, 19.4 ± 7.9 min; Group II, 29.6 ± 11.4 min; p ESWL procedures in paediatric patients and shortens recovery time.

Current status of NPP generation IV

International Nuclear Information System (INIS)

Yohanes Dwi Anggoro; Dharu Dewi; Nurlaila; Arief Tris Yuliyanto

2013-01-01

Today development of nuclear technology has reached the stage of research and development of Generation IV nuclear power plants (advanced reactor systems) which is an innovative development from the previous generation of nuclear power plants. There are six types of power generation IV reactors, namely: Very High Temperature Reactor (VHTR), Sodium-cooled Fast Reactor (SFR), Gas-cooled Fast Reactor (GFR), Lead-cooled Fast Reactor (LFR), Molten Salt Reactor (MSR), and Super Critical Water-cooled Reactor (SCWR). The purpose of this study is to know the development of Generation IV nuclear power plants that have been done by the thirteen countries that are members of the Gen IV International Forum (GIF). The method used is review study and refers to various studies related to the current status of research and development of generation IV nuclear power. The result of this study showed that the systems and technology on Generation IV nuclear power plants offer significant advances in sustainability, safety and reliability, economics, and proliferation resistance and physical protection. In addition, based on the research and development experience is estimated that: SFR can be used optimally in 2015, VHTR in 2020, while NPP types GFR, LFR, MSR, and SCWR in 2025. Utilization of NPP generation IV said to be optimal if fulfill the goal of NPP generation IV, such as: capable to generate energy sustainability and promote long-term availability of nuclear fuel, minimize nuclear waste and reduce the long term stewardship burden, has an advantage in the field of safety and reliability compared to the previous generation of NPP and VHTR technology have a good prospects in Indonesia. (author)

BALTICA IV. Plant maintenance for managing life and performance

Energy Technology Data Exchange (ETDEWEB)

Hietanen, S; Auerkari, P [eds.; VTT Manufacturing Technology, Espoo (Finland). Operational Reliability

1999-12-31

BALTICA IV International Conference on Plant Maintenance Managing Life and performance held on September 7-9, 1998 on board M/S Silja Symphony on its cruise between Helsinki-Stockholm and at Aavaranta in Kirkkonummi. The BALTICA IV conference provides a forum for the transfer of technology from applied research to practice. This is one of the two volumes of the proceedings of the BALTICA IV International Conference on Plant Maintenance Managing Life and Performance. The BALTICA IV conference focuses on new technology, recent experience and applications of condition and life management, and on improvements in maintenance strategies for safe and economical operation of power plants. (orig.)

BALTICA IV. Plant maintenance for managing life and performance

Energy Technology Data Exchange (ETDEWEB)

Hietanen, S.; Auerkari, P. [eds.] [VTT Manufacturing Technology, Espoo (Finland). Operational Reliability

1998-12-31

BALTICA IV International Conference on Plant Maintenance Managing Life and performance held on September 7-9, 1998 on board M/S Silja Symphony on its cruise between Helsinki-Stockholm and at Aavaranta in Kirkkonummi. The BALTICA IV conference provides a forum for the transfer of technology from applied research to practice. This is one of the two volumes of the proceedings of the BALTICA IV International Conference on Plant Maintenance Managing Life and Performance. The BALTICA IV conference focuses on new technology, recent experience and applications of condition and life management, and on improvements in maintenance strategies for safe and economical operation of power plants. (orig.)

Environmental assessment for operations, upgrades, and modifications in SNL/NM Technical Area IV

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-04-01

The proposed action for this EA for Sandia National Laboratories/New Mexico Technical Area IV, includes continuing existing operations, modification of an existing accelerator (Particle Beam Fusion Accelerator II) to support defnese-related Z-pinch experiments, and construction of two transformer oil storage tanks to support the expansion of the Advanced Pulsed Power Research Module, a single pulse accelerator. Based on the analyses in the EA, DOE believes that the proposed action is not a major federal action significantly affecting the quality of the human environment within the meaning of NEPA and CEQ NEPA implementing regulations in 40 CFR 1508.18 and 1508.27. Therefore, an environmental impact statement is not required, and a Finding of No Significant Impact is issued.

Environmental assessment for operations, upgrades, and modifications in SNL/NM Technical Area IV

International Nuclear Information System (INIS)

1996-04-01

The proposed action for this EA for Sandia National Laboratories/New Mexico Technical Area IV, includes continuing existing operations, modification of an existing accelerator (Particle Beam Fusion Accelerator II) to support defnese-related Z-pinch experiments, and construction of two transformer oil storage tanks to support the expansion of the Advanced Pulsed Power Research Module, a single pulse accelerator. Based on the analyses in the EA, DOE believes that the proposed action is not a major federal action significantly affecting the quality of the human environment within the meaning of NEPA and CEQ NEPA implementing regulations in 40 CFR 1508.18 and 1508.27. Therefore, an environmental impact statement is not required, and a Finding of No Significant Impact is issued

Results on QCD Physics from the CDF-II Experiment

Energy Technology Data Exchange (ETDEWEB)

Pagliarone, C.; /Cassino U. /INFN, Pisa

2006-12-01

In this paper the authors review a selection of recent results obtained, in the area of QCD physics, from the CDF-II experiment that studies p{bar p} collisions at {radical}s = 1.96 TeV provided by the Fermilab Tevatron Collider. All results shown correspond to analysis performed using the Tevatron Run II data samples. In particular they will illustrate the progress achieved and the status of the studies on the following QCD processes: jet inclusive production, using different jet clustering algorithm, W({yields} e{nu}{sub e}) + jets and Z({yields} e{sup +}e{sup -}) + jets production, {gamma} + b-jet production, dijet production in double pomeron exchange and finally exclusive e{sup +}e{sup -} and {gamma}{gamma} production. No deviations from the Standard Model have been observed so far.

Identification of novel human dipeptidyl peptidase-IV inhibitors of natural origin (Part II: in silico prediction in antidiabetic extracts.

Directory of Open Access Journals (Sweden)

Laura Guasch

Full Text Available BACKGROUND: Natural extracts play an important role in traditional medicines for the treatment of diabetes mellitus and are also an essential resource for new drug discovery. Dipeptidyl peptidase IV (DPP-IV inhibitors are potential candidates for the treatment of type 2 diabetes mellitus, and the effectiveness of certain antidiabetic extracts of natural origin could be, at least partially, explained by the inhibition of DPP-IV. METHODOLOGY/PRINCIPAL FINDINGS: Using an initial set of 29,779 natural products that are annotated with their natural source and an experimentally validated virtual screening procedure previously developed in our lab (Guasch et al.; 2012 [1], we have predicted 12 potential DPP-IV inhibitors from 12 different plant extracts that are known to have antidiabetic activity. Seven of these molecules are identical or similar to molecules with described antidiabetic activity (although their role as DPP-IV inhibitors has not been suggested as an explanation for their bioactivity. Therefore, it is plausible that these 12 molecules could be responsible, at least in part, for the antidiabetic activity of these extracts through their inhibitory effect on DPP-IV. In addition, we also identified as potential DPP-IV inhibitors 6 molecules from 6 different plants with no described antidiabetic activity but that share the same genus as plants with known antidiabetic properties. Moreover, none of the 18 molecules that we predicted as DPP-IV inhibitors exhibits chemical similarity with a group of 2,342 known DPP-IV inhibitors. CONCLUSIONS/SIGNIFICANCE: Our study identified 18 potential DPP-IV inhibitors in 18 different plant extracts (12 of these plants have known antidiabetic properties, whereas, for the remaining 6, antidiabetic activity has been reported for other plant species from the same genus. Moreover, none of the 18 molecules exhibits chemical similarity with a large group of known DPP-IV inhibitors.

Preparation and estimation of thermodynamic properties of Fe(II)-, Co(II)-, Ni(II)- and Zr(IV)-containing layered double hydroxides

Energy Technology Data Exchange (ETDEWEB)

Rozov, Konstantin; Curtius, Hilde; Bosbach, Dirk [Forschungszentrum Juelich GmbH (Germany). Inst. for Nuclear Waste Management and Reactor Safety (IEK-6)

2015-07-01

The investigation of layered double hydroxides (LDHs) was performed because they and similar 'green rust' phases were identified as specific secondary phases forming during the evolution of the disposed research reactor fuel elements under nuclear repository relevant conditions. LDHs or 'hydrotalcite-like' solids are of interest in environmental geochemistry because they can substitute various cations and especially due to the anion-exchange properties and, therefore, can be considered as buffer materials for retention of mobile and hazardous radionuclides (like, {sup 14}C, {sup 129}I, {sup 36}Cl, {sup 79}Se etc.). In our study Fe{sup 2+}-, Co{sup 2+}-, Ni{sup 2+}- and Zr{sup 4+}-containing LDHs have been synthesized by co-precipitation method and characterized (PXRD, FT-IR, SEM-EDX, TGA-DSC) in order to investigate the effect of substitution of 2- and 4-valent cations on the stability of LDHs. PXRD measurements demonstrated that: (1) pure Mg-Al-Fe(II) LDHs are existing in the range of the mole fraction of iron x{sub Fe} = Fe/(Mg+Fe) between 0 and 0.13. Unit-cell parameters (a{sub o}=b{sub o}) as a function of x{sub Fe} follow Vegard's law corroborating the existence of a solid solution when x{sub Fe} = 0 - 0.13. Products of syntheses with x{sub Fe} ≥ 0.13 contain detectable amounts (≥1-2 wt%) of additional phases (like, magnetite, maghemite, lepidocrocite); (2) pure Ni{sup 2+}- and Co{sup 2+}-containing LDHs (mole fractions of Ni and Co were equal to 0.1) have been synthesized successfully; (3) Mg-Al-Zr(IV) precipitates with mole fraction of zirconium x{sub Zr} = Zr/(Zr+Al) = 0.0 - 0.5 show PXRD patterns attributed to pure LDHs and the variation of lattice parameters a{sub o}=b{sub o} as a function of x{sub Zr} is in agreement with Vegard's law demonstrating the presence of solid solution. In contrast, PXRD analyses of precipitates with x{sub Zr} ≥ 0.5 have shown the presence of additional X-ray reflexes typical for brucite. The

U-233 fuelled low critical mass solution reactor experiment PURNIMA II

International Nuclear Information System (INIS)

Srinivasan, M.; Chandramoleshwar, K.; Pasupathy, C.S.; Rasheed, K.K.; Subba Rao, K.

1987-01-01

A homogeneous U-233 uranyl nitrate solution fuelled BeO reflected, low critical mass reactor has been built at the Bhabha Atomic Research Centre, India. Christened PURNIMA II, the reactor was used for the study of the variation of critical mass as a function of fuel solution concentration to determine the minimum critical mass achievable for this geometry. Other experiments performed include the determination of temperature coefficient of reactivity, study of time behaviour of photoneutrons produced due to interaction between decaying U-233 fission product gammas and the beryllium reflector and reactor noise measurements. Besides being the only operational U-233 fuelled reactor at present, PURNIMA II also has the distinction of having attained the lowest critical mass of 397 g of fissile fuel for any operating reactor at the current time. The paper briefly describes the facility and gives an account of the experiments performed and results achieved. (author)

Angiotensin IV and the human esophageal mucosa: An exploratory study in healthy subjects and gastroesophageal reflux disease patients.

Science.gov (United States)

Björkman, Eleonora; Edebo, Anders; Fändriks, Lars; Casselbrant, Anna

2015-09-01

The human esophageal mucosa expresses various components of the renin-angiotensin system (RAS), e.g. the main effector peptide angiotensin II (AngII). The aim of this study was to investigate the esophageal presence of angiotensin III (AngIII) and angiotensin IV (AngIV) forming enzymes and the AngIV receptor (AT4R). The aim was also to study the actions of AngIV and to look for aberrations in patients with gastroesophageal reflux disease (GERD). Esophageal biopsies were collected from healthy volunteers (n: 19) and individuals with erosive reflux disease (n: 14). Gene transcripts and protein expression of aminopeptidase A, -B and -M, and the AT4R were investigated by reverse transcriptase polymerase chain reaction (rt-PCR), western blot (WB) and immunohistochemistry (IHC). The functional impact of AngIV was examined in an Ussing chamber. Aminopeptidase A, -B and -M and the AT4R were expressed in the esophageal epithelium. The AT4R was less prominent in certain areas in the mucosa of reflux patients. AngIV influenced the esophageal epithelial ion transport. The impact was lower in patients with GERD. The AT4R and formation enzymes of AngIII and AngIV are present in the human esophageal epithelium. Moreover, the present results suggest that AngIV exert regulatory impact on the epithelium and that RAS is involved in mucosal aberrations associated with GERD. © The Author(s) 2014.

Latest experiences and future plans on NSLS-II insertion devices

Energy Technology Data Exchange (ETDEWEB)

Tanabe, T.; Hidaka, Y.; Kitegi, C.; Hidas, D.; Musardo, M.; Harder, D. A.; Rank, J.; Cappadoro, P.; Fernandes, H.; Corwin, T. [Energy Sciences Directorate, Brookhaven National Laboratory, Upton, NY 11973, U.S.A (United States)

2016-07-27

National Synchrotron Light Source-II (NSLS-II) is the latest storage ring of 3 GeV energy at the Brookhaven National Laboratory (BNL). The horizontal emittance of the electron beam with the currently installed six damping wigglers is 0.9 nm.rad, which could be further reduced to 0.5 nm.rad with more insertion devices (IDs). With only one RF cavity the beam current is restricted to 200 mA. Five hundred mA operation is envisaged for next year with an addition of the second cavity. Six (plus two branches) beamlines have been commissioned in the initial phase of the project. In July 2015, three NIH funded beamlines called “Advanced Beamlines for Biological Investigations with X-rays” (ABBIX) will be added for operation. This paper describes the experiences of ID development, installation, and commissioning for the NSLS-II project as well as our future plans to improve the performance of the facility in terms of source development.

BMFT-CEA-US-DOE Exchange on KNK II-Rapsodie-EBR II operating experience, German contributions for the second expert meeting at Idaho Falls, USA, October 27 and 28, 1982

International Nuclear Information System (INIS)

1982-10-01

The meeting at Idaho Falls was the follow-up meeting of the first expert meeting on EBR II- Rapsodie- KNK II operating experience, which took place at the Karlsruhe Research Center in March 1980. The present report compiles the ten German papers presented at the Idaho Falls meeting, discussing various aspects of experience gained by the operation of KNK II

Polyvalent type IV sensitizations to multiple fragrances and a skin protection cream in a metal worker.

Science.gov (United States)

Tanko, Zita; Shab, Arna; Diepgen, Thomas Ludwig; Weisshaar, Elke

2009-06-01

Fragrances are very common in everyday products. A metalworker with chronic hand eczema and previously diagnosed type IV sensitizations to epoxy resin, balsam of Peru, fragrance mix and fragrance mix II was diagnosed with additional type IV sensitizations to geraniol, hydroxycitronellal, lilial, tree moss, oak moss absolute, citral, citronellol, farnesol, Lyral, fragrance mix II and fragrance mix (with sorbitan sesquioleate). In addition, a type IV sensitization to the skin protection cream containing geraniol and citronellol used at the workplace was detected, and deemed occupationally relevant in this case. The patient could have had contact to fragrances through private use of cosmetics and detergents. On the other hand, the fragrance-containing skin protection cream supports occupational exposure. This case report demonstrates that fragrance contact allergy has to be searched for and clarified individually, which requires a thorough history and a detailed analysis of the work place.

Complexation of Plutonium (IV) With Sulfate At Variable Temperatures

International Nuclear Information System (INIS)

Y. Xia; J.I. Friese; D.A. Moore; P.P. Bachelor; L. Rao

2006-01-01

The complexation of plutonium(IV) with sulfate at variable temperatures has been investigated by solvent extraction method. A NaBrO 3 solution was used as holding oxidant to maintain the plutonium(IV) oxidation state throughout the experiments. The distribution ratio of Pu(IV) between the organic and aqueous phases was found to decrease as the concentrations of sulfate were increased. Stability constants of the 1:1 and 1:2 Pu(IV)-HSO 4 - complexes, dominant in the aqueous phase, were calculated from the effect of [HSO 4 - ] on the distribution ratio. The enthalpy and entropy of complexation were calculated from the stability constants at different temperatures using the Van't Hoff equation

Database usage and performance for the Fermilab Run II experiments

International Nuclear Information System (INIS)

Bonham, D.; Box, D.; Gallas, E.; Guo, Y.; Jetton, R.; Kovich, S.; Kowalkowski, J.; Kumar, A.; Litvintsev, D.; Lueking, L.; Stanfield, N.; Trumbo, J.; Vittone-Wiersma, M.; White, S.P.; Wicklund, E.; Yasuda, T.; Maksimovic, P.

2004-01-01

The Run II experiments at Fermilab, CDF and D0, have extensive database needs covering many areas of their online and offline operations. Delivering data to users and processing farms worldwide has represented major challenges to both experiments. The range of applications employing databases includes, calibration (conditions), trigger information, run configuration, run quality, luminosity, data management, and others. Oracle is the primary database product being used for these applications at Fermilab and some of its advanced features have been employed, such as table partitioning and replication. There is also experience with open source database products such as MySQL for secondary databases used, for example, in monitoring. Tools employed for monitoring the operation and diagnosing problems are also described

Peroxiredoxin IV Protects Cells From Radiation-Induced Apoptosis in Head-and-Neck Squamous Cell Carcinoma

International Nuclear Information System (INIS)

Park, Jung Je; Chang, Hyo Won; Jeong, Eun-Jeong; Roh, Jong-Lyel; Choi, Seung-Ho; Jeon, Sea-Yuong; Ko, Gyung Hyuck; Kim, Sang Yoon

2009-01-01

Purpose: Human peroxiredoxins (Prxs) are known as a family of thiol-specific antioxidant enzymes, among which Prx-I and -II play an important role in protecting cells from irradiation-induced cell death. It is not known whether Prx-IV also protects cells from ionizing radiation (IR). Methods and Materials: To evaluate the protective role of Prx-IV in IR, we transfected full-length Prx-IV cDNA into AMC-HN3 cells, which weakly express endogenous Prx-IV, and knocked down the expression of Prx-IV with siRNA methods using AMC-HN7 cells, which express high levels of endogenous Prx-IV. Radiosensitivity profiles in these cells were evaluated using clonogenic assay, FACS analysis, cell viability, and TUNEL assay. Results: Three Prx-IV expressing clones were isolated. Prx-IV regulated intracellular reactive oxygen species (ROS) levels and made cells more resistant to IR-induced apoptosis. Furthermore, the knockdown of Prx-IV with siRNA made cells more sensitive to IR-induced apoptosis. Conclusion: The results of these studies suggest that Prx-IV may play an important role in protecting cells from IR-induced apoptosis in head-and-neck squamous cell carcinoma

SiPM-based azimuthal position sensor in ANITA-IV Hi-Cal Antarctic balloon experiment

Science.gov (United States)

Novikov, A.; Besson, D.; Chernysheva, I.; Dmitrenko, V.; Grachev, V.; Petrenko, D.; Prohira, S.; Shustov, A.; Ulin, S.; Uteshev, Z.; Vlasik, K.

2017-01-01

Hi-Cal (High-Altitude Calibration) is a balloon-borne experiment that will be launched in December, 2016 in Antarctica following ANITA-IV (Antarctic Impulsive Transient Antenna) and will generate a broad-band pulse over the frequency range expected from radiation induced by a cosmic ray shower. Here, we describe a device based on an array of silicon photomultipliers (SiPMs) for determination of the azimuthal position of Hi-Cal. The angular resolution of the device is about 3 degrees. Since at the float altitude of ˜38 km the pressure will be ˜0.5 mbar and temperature ˜ - 20 °C, the equipment has been tested in a chamber over a range of corresponding pressures (0.5 ÷ 1000) mbar and temperatures (-40 ÷ +50) °C.

SiPM-based azimuthal position sensor in ANITA-IV Hi-Cal Antarctic balloon experiment

International Nuclear Information System (INIS)

Novikov, A; Besson, D; Chernysheva, I; Dmitrenko, V; Grachev, V; Petrenko, D; Shustov, A; Ulin, S; Uteshev, Z; Vlasik, K; Prohira, S

2017-01-01

Hi-Cal (High-Altitude Calibration) is a balloon-borne experiment that will be launched in December, 2016 in Antarctica following ANITA-IV (Antarctic Impulsive Transient Antenna) and will generate a broad-band pulse over the frequency range expected from radiation induced by a cosmic ray shower. Here, we describe a device based on an array of silicon photomultipliers (SiPMs) for determination of the azimuthal position of Hi-Cal. The angular resolution of the device is about 3 degrees. Since at the float altitude of ∼38 km the pressure will be ∼0.5 mbar and temperature ∼ − 20 °C, the equipment has been tested in a chamber over a range of corresponding pressures (0.5 ÷ 1000) mbar and temperatures (−40 ÷ +50) °C. (paper)

A Virtual Reality Framework to Optimize Design, Operation and Refueling of GEN-IV Reactors

International Nuclear Information System (INIS)

Rizwan-uddin; Nick Karancevic; Stefano Markidis; Joel Dixon; Cheng Luo; Jared Reynolds

2008-01-01

Many GEN-IV candidate designs are currently under investigation. Technical issues related to material, safety and economics are being addressed at research laboratories, industry and in academia. After safety, economic feasibility is likely to be the most important criterion in the success of GEN-IV design(s). Lessons learned from the designers and operators of GEN-II (and GEN-III) reactors must play a vital role in achieving both safety and economic feasibility goals

A Virtual Reality Framework to Optimize Design, Operation and Refueling of GEN-IV Reactors.

Energy Technology Data Exchange (ETDEWEB)

Rizwan-uddin; Nick Karancevic; Stefano Markidis; Joel Dixon; Cheng Luo; Jared Reynolds

2008-04-23

many GEN-IV candidate designs are currently under investigation. Technical issues related to material, safety and economics are being addressed at research laboratories, industry and in academia. After safety, economic feasibility is likely to be the most important crterion in the success of GEN-IV design(s). Lessons learned from the designers and operators of GEN-II (and GEN-III) reactors must play a vital role in achieving both safety and economic feasibility goals.

Measurement of Ce(IV) Concentration in Foam Decontaminant containing Fluorosurfactant

Energy Technology Data Exchange (ETDEWEB)

Jung, Chong Hun; Yang, H. B.; Yoon, I. H.; Choi, W. K.; Moon, J. K. [KAERI, Daejeon (Korea, Republic of); Lee, J. S. [Gachon University, Seongnam (Korea, Republic of)

2016-05-15

To improve the stability of the foam, surfactants and inorganic materials such as nanoparticles can be added. A nanoparticle-based foam decontaminant is composed of a surfactant and nanoparticles for the generation and maintenance of foam, and a chemical decontamination agent made of Ce(IV) dissolved in nitric acid. Ce(IV) will be reduced to Ce(III) through the decontamination process. Oxidizing the cerium (III) can be reused as a decontamination agent, Ce(IV). Oxidation treatment technology by ozone uses its strong oxidizing power. It can be regarded as an environmentally friendly process, because ozone cannot be stored and transported like other industrial gases (because it quickly decays into diatomic oxygen) and must therefore be produced on site, and used ozone can be decomposed immediately. A concentration analysis of Ce(IV) in foam decontaminant containing a surfactant is necessary prior to the derivation of optimal conditions for the regeneration of Ce(III) through ozonation treatment. A UV spectrometric method using the absorbance or potentiometric method with a potential difference in Ce(III)/Ce(IV), or a potentiometric titration method using Fe (II), can be used for a Ce(IV) concentration analysis. A UV spectrometric method has a problem receiving the influence of the surfactant, and a potentiometric method is difficult to use because of the problem of an insignificant change in the potential difference value of the Ce(III)/Ce(IV). Thus, the present study was undertaken to determine whether the potentiometric titration method can be used for an analysis of the Ce(IV) concentration in the nanoparticle-based foam decontaminant containing surfactant. It will be effectively used for the Ce(IV) concentration measurement, in relation to the subsequent research on the derivation of optimal conditions for the regeneration of Ce(III) through ozonation treatment.

Conversion of Phase II Unsteady Aerodynamics Experiment Data to Common Format; TOPICAL

International Nuclear Information System (INIS)

Hand, M. M.

1999-01-01

A vast amount of aerodynamic, structural, and turbine performance data were collected during three phases of the National Renewable Energy Laboratory's Unsteady Aerodynamics Experiment (UAE). To compare data from the three phases, a similar format of engineering unit data is required. The process of converting Phase II data from a previous engineering unit format to raw integer counts is discussed. The integer count files can then be input to the new post-processing software, MUNCH. The resulting Phase II engineering unit files are in a common format with current and future UAE engineering unit files. An additional objective for changing the file format was to convert the Phase II data from English units to SI units of measurement

Platinum(iv) prodrug conjugated Pd@Au nanoplates for chemotherapy and photothermal therapy

Science.gov (United States)

Shi, Saige; Chen, Xiaolan; Wei, Jingping; Huang, Yizhuan; Weng, Jian; Zheng, Nanfeng

2016-03-01

Owing to the excellent near infrared (NIR) light absorption and efficient passive targeting toward tumor tissue, two-dimensional (2D) core-shell PEGylated Pd@Au nanoplates have great potential in both photothermal therapy and drug delivery systems. In this work, we successfully conjugate Pd@Au nanoplates with a platinum(iv) prodrug c,c,t-[Pt(NH3)2Cl2(O2CCH2CH2CO2H)2] to obtain a nanocomposite (Pd@Au-PEG-Pt) for combined photothermal-chemotherapy. The prepared Pd@Au-PEG-Pt nanocomposite showed excellent stability in physiological solutions and efficient Pt(iv) prodrug loading. Once injected into biological tissue, the Pt(iv) prodrug was easily reduced by physiological reductants (e.g. ascorbic acid or glutathione) into its cytotoxic and hydrophilic Pt(ii) form and released from the original nanocomposite, and the NIR laser irradiation could accelerate the release of Pt(ii) species. More importantly, Pd@Au-PEG-Pt has high tumor accumulation (29%ID per g), which makes excellent therapeutic efficiency at relatively low power density possible. The in vivo results suggested that, compared with single therapy the combined thermo-chemotherapy treatment with Pd@Au-PEG-Pt resulted in complete destruction of the tumor tissue without recurrence, while chemotherapy using Pd@Au-PEG-Pt without irradiation or photothermal treatment using Pd@Au-PEG alone did not. Our work highlights the prospects of a feasible drug delivery strategy of the Pt prodrug by using 2D Pd@Au nanoplates as drug delivery carriers for multimode cancer treatment.Owing to the excellent near infrared (NIR) light absorption and efficient passive targeting toward tumor tissue, two-dimensional (2D) core-shell PEGylated Pd@Au nanoplates have great potential in both photothermal therapy and drug delivery systems. In this work, we successfully conjugate Pd@Au nanoplates with a platinum(iv) prodrug c,c,t-[Pt(NH3)2Cl2(O2CCH2CH2CO2H)2] to obtain a nanocomposite (Pd@Au-PEG-Pt) for combined photothermal-chemotherapy. The

Chemical Remediation of Nickel(II) Waste: A Laboratory Experiment for General Chemistry Students

Science.gov (United States)

Corcoran, K. Blake; Rood, Brian E.; Trogden, Bridget G.

2011-01-01

This project involved developing a method to remediate large quantities of aqueous waste from a general chemistry laboratory experiment. Aqueous Ni(II) waste from a general chemistry laboratory experiment was converted into solid nickel hydroxide hydrate with a substantial decrease in waste volume. The remediation method was developed for a…

Integral decay-heat measurements and comparisons to ENDF/B--IV and V

International Nuclear Information System (INIS)

England, T.R.; Schenter, R.E.; Schmittroth, F.

Results from recent integral decay-power experiments are presented and compared with summation calculations. The experiments include the decay power following thermal fission of 233 U, 235 U, and 239 Pu. The summation calculations use ENDF/B-IV decay data and yields from Versions IV and V. Limited comparisons of experimental β and γ spectra with summation calculations using ENDF/B-IV are included. Generalized least-squares methods are applied to the recent 235 U and 239 Pu decay-power experiments and summation calculations to arrive at evaluated values and uncertainties. Results for 235 U imply uncertainties less than 2% (1 sigma) for the ''infinite'' exposure case for all cooling times greater than 10 seconds. The uncertainties for 239 Pu are larger. Accurate analytical representations of the decay power are presented for 235 , 238 U, and 239 Pu for use in light-water reactors and as the nominal values in the new ANS 5.1 Draft Standard (1978). Comparisons of the nominal values with ENDF/B-IV and the 1973 ANS Draft Standard in current use are included. Gas content, important to decay-heat experiments, and absorption effects on decay power are reviewed. 37 figures, 8 tables

On the Importance of the Nonequilibrium Ionization of Si IV and O IV and the Line of Sight in Solar Surges

Science.gov (United States)

Nóbrega-Siverio, D.; Moreno-Insertis, F.; Martínez-Sykora, J.

2018-05-01

Surges are ubiquitous cool ejections in the solar atmosphere that often appear associated with transient phenomena like UV bursts or coronal jets. Recent observations from the Interface Region Imaging Spectrograph show that surges, although traditionally related to chromospheric lines, can exhibit enhanced emission in Si IV with brighter spectral profiles than for the average transition region (TR). In this paper, we explain why surges are natural sites to show enhanced emissivity in TR lines. We performed 2.5D radiative-MHD numerical experiments using the Bifrost code including the nonequilibrium (NEQ) ionization of silicon and oxygen. A surge is obtained as a by-product of magnetic flux emergence; the TR enveloping the emerged domain is strongly affected by NEQ effects: assuming statistical equilibrium would produce an absence of Si IV and O IV ions in most of the region. Studying the properties of the surge plasma emitting in the Si IV λ1402.77 and O IV λ1401.16 lines, we find that (a) the timescales for the optically thin losses and heat conduction are very short, leading to departures from statistical equilibrium, and (b) the surge emits in Si IV more and has an emissivity ratio of Si IV to O IV larger than a standard TR. Using synthetic spectra, we conclude the importance of line-of-sight effects: given the involved geometry of the surge, the line of sight can cut the emitting layer at small angles and/or cross it multiple times, causing prominent, spatially intermittent brightenings in both Si IV and O IV.

X447 EBR-II Experiment Benchmark for Verification of Audit Code of SFR Metal Fuel

Energy Technology Data Exchange (ETDEWEB)

Choi, Yong Won; Bae, Moo-Hoon; Shin, Andong; Suh, Namduk [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

2016-10-15

In KINS (Korea Institute of Nuclear Safety), to prepare audit calculation of PGSFR licensing review, the project has been started to develop the regulatory technology for SFR system including a fuel area. To evaluate the fuel integrity and safety during an irradiation, the fuel performance code must be used for audit calculation. In this study, to verify the new code system, the benchmark analysis is performed. In the benchmark, X447 EBR-II experiment data are used. Additionally, the sensitivity analysis according to mass flux change of coolant is performed. In case of LWR fuel performance modeling, various and advanced models have been proposed and validated based on sufficient in-reactor test results. However, due to the lack of experience of SFR operation, the current understanding of SFR fuel behavior is limited. In this study, X447 EBR-II Experiment data are used for benchmark. The fuel composition of X447 assembly is U-10Zr and PGSFR also uses this composition in initial phase. So we select X447 EBR-II experiment for benchmark analysis. Due to the lack of experience of SFR operation and data, the current understanding of SFR fuel behavior is limited. However, in order to prepare the licensing of PGSFR, regulatory audit technologies of SFR must be secured. So, in this study, to verify the new audit fuel performance analysis code, the benchmark analysis is performed using X447 EBR-II experiment data. Also, the sensitivity analysis with mass flux change of coolant is performed. In terms of verification, it is considered that the results of benchmark and sensitivity analysis are reasonable.

X447 EBR-II Experiment Benchmark for Verification of Audit Code of SFR Metal Fuel

International Nuclear Information System (INIS)

Choi, Yong Won; Bae, Moo-Hoon; Shin, Andong; Suh, Namduk

2016-01-01

In KINS (Korea Institute of Nuclear Safety), to prepare audit calculation of PGSFR licensing review, the project has been started to develop the regulatory technology for SFR system including a fuel area. To evaluate the fuel integrity and safety during an irradiation, the fuel performance code must be used for audit calculation. In this study, to verify the new code system, the benchmark analysis is performed. In the benchmark, X447 EBR-II experiment data are used. Additionally, the sensitivity analysis according to mass flux change of coolant is performed. In case of LWR fuel performance modeling, various and advanced models have been proposed and validated based on sufficient in-reactor test results. However, due to the lack of experience of SFR operation, the current understanding of SFR fuel behavior is limited. In this study, X447 EBR-II Experiment data are used for benchmark. The fuel composition of X447 assembly is U-10Zr and PGSFR also uses this composition in initial phase. So we select X447 EBR-II experiment for benchmark analysis. Due to the lack of experience of SFR operation and data, the current understanding of SFR fuel behavior is limited. However, in order to prepare the licensing of PGSFR, regulatory audit technologies of SFR must be secured. So, in this study, to verify the new audit fuel performance analysis code, the benchmark analysis is performed using X447 EBR-II experiment data. Also, the sensitivity analysis with mass flux change of coolant is performed. In terms of verification, it is considered that the results of benchmark and sensitivity analysis are reasonable

Technetium electrochemistry. 7. Electrochemical and spectroelectrochemical studies on technetium(III) and -(II) complexes containing polypyridyl ligands

International Nuclear Information System (INIS)

Wilcox, B.E.; Deutsch, E.

1991-01-01

The redox properties of a series of technetium(III/II) complexes of the general formula cis(X), trans(P)-[Tc III/II X 2 (PR w R') 2 L] 10+ , where X = Cl or Br, PR 2 R' = dimethylphenylphosphine or ethyldiphenylphosphine, and L = 2,2'-bipyridine (bpy), 4,4'-dimethyl-2,2'-bipyridine (Me 2 bpy), or 1,10-phenanthroline (phen), were investigated in 0.1 M TEAP/acetonitrile by cyclic voltammetry at a platinum-disk electrode. These complexes exhibit diffusion-controlled, 1-equiv Tc(IV)/Tc(III) redox couples and also Tc(III)/Tc(II) redox couples. Spectropotentiostatic experiments on three complexes of this class in 0.5 M TEAP/DMF confirm the 1-equiv character of the Tc(III)/Tc(II) couple. The electrochemical behavior of Tc(II) complexes of the general formula trans(P)-[TcX(PR 2 R') 2 terpy] + , terpy = 2,2':6',2 double-prime-terpyridine, was also investigated under the same conditions as above. These complexes exhibit diffusion-controlled, 1-equiv Tc(III)/Tc(II) redox couples and Tc(II)/Tc(I) redox couples. Spectropotentiostatic experiments on trans(P)-[TcCl(PMe 2 Ph) 2 terpy] + confirm the 1-equiv character of the Tc(III)/Tc(II) couple but show that the Tc(II)/Tc(I) couple is not reversible on the spectropotentiostatic time scale

CSNI Project for Fracture Analyses of Large-Scale International Reference Experiments (FALSIRE II)

Energy Technology Data Exchange (ETDEWEB)

Bass, B.R.; Pugh, C.E.; Keeney, J. [Oak Ridge National Lab., TN (United States); Schulz, H.; Sievers, J. [Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS) mbH, Koeln (Gemany)

1996-11-01

A summary of Phase II of the Project for FALSIRE is presented. FALSIRE was created by the Fracture Assessment Group (FAG) of the OECD/NEA`s Committee on the Safety of Nuclear Installations (CNSI) Principal Working Group No. 3. FALSIRE I in 1988 assessed fracture methods through interpretive analyses of 6 large-scale fracture experiments in reactor pressure vessel (RPV) steels under pressurized- thermal-shock (PTS) loading. In FALSIRE II, experiments examined cleavage fracture in RPV steels for a wide range of materials, crack geometries, and constraint and loading conditions. The cracks were relatively shallow, in the transition temperature region. Included were cracks showing either unstable extension or two stages of extensions under transient thermal and mechanical loads. Crack initiation was also investigated in connection with clad surfaces and with biaxial load. Within FALSIRE II, comparative assessments were performed for 7 reference fracture experiments based on 45 analyses received from 22 organizations representing 12 countries. Temperature distributions in thermal shock loaded samples were approximated with high accuracy and small scatter bands. Structural response was predicted reasonably well; discrepancies could usually be traced to the assumed material models and approximated material properties. Almost all participants elected to use the finite element method.

CSNI Project for Fracture Analyses of Large-Scale International Reference Experiments (FALSIRE II)

International Nuclear Information System (INIS)

Bass, B.R.; Pugh, C.E.; Keeney, J.; Schulz, H.; Sievers, J.

1996-11-01

A summary of Phase II of the Project for FALSIRE is presented. FALSIRE was created by the Fracture Assessment Group (FAG) of the OECD/NEA's Committee on the Safety of Nuclear Installations (CNSI) Principal Working Group No. 3. FALSIRE I in 1988 assessed fracture methods through interpretive analyses of 6 large-scale fracture experiments in reactor pressure vessel (RPV) steels under pressurized- thermal-shock (PTS) loading. In FALSIRE II, experiments examined cleavage fracture in RPV steels for a wide range of materials, crack geometries, and constraint and loading conditions. The cracks were relatively shallow, in the transition temperature region. Included were cracks showing either unstable extension or two stages of extensions under transient thermal and mechanical loads. Crack initiation was also investigated in connection with clad surfaces and with biaxial load. Within FALSIRE II, comparative assessments were performed for 7 reference fracture experiments based on 45 analyses received from 22 organizations representing 12 countries. Temperature distributions in thermal shock loaded samples were approximated with high accuracy and small scatter bands. Structural response was predicted reasonably well; discrepancies could usually be traced to the assumed material models and approximated material properties. Almost all participants elected to use the finite element method

Phonons: Theory and experiments II. Volume 2

International Nuclear Information System (INIS)

Bruesch, P.

1986-01-01

The present second volume titled as ''Phonons: Theory and Experiments II'', contains, a thorough study of experimental techniques and the interpretation of experimental results. This three-volume set tries to bridge the gap between theory and experiment, and is addressed to those working in both camps in the vast field of dynamical properties of solids. Topics presented in the second volume include; infrared-, Raman and Brillouin spectroscopy, interaction of X-rays with phonons, and inelastic neutron scattering. In addition an account is given of some other techniques, including ultrasonic methods, inelastic electron tunneling spectroscopy, point contact spectroscopy, and spectroscopy of surface phonons, thin films and adsorbates. Both experimental aspects and theoretical concepts necessary for the interpretation of experimental data are discussed. An attempt is made to present the descriptive as well as the analytical aspects of the topics. Simple models are often used to illustrate the basic concepts and more than 100 figures are included to illustrate both theoretical and experimental results. Many chapters contain a number of problems with hints and results giving additional information

Clinical experience with radiation enhancement by hyperbaric oxygen in children with recurrent neuroblastoma stage IV

International Nuclear Information System (INIS)

Voute, P.A.; Kleij, A.J. van der; De Kraker, J.; Hoefnagel, C.A.; Tiel-van Buul, M.M.C.; Gennip, H. van

1995-01-01

The high risk group of patients with neuroblastoma are children over 1 year with stage IV disease. Most series report a maximum of 20% survival at 5 years. For recurrent neuroblastoma stage IV, cure rates are not reported in the literature, but they are nil. Any treatment for recurrent neuroblastoma stage IV remains a therapeutic dilemma. The outcome of radiation therapy is variable. A very important factor in tumour treatment remains tumour hypoxia, and others, such as metabolic factors, also play a role. Combined application of radiation modifiers may influence the final survival rate. In an attempt to improve the survival of recurrent neuroblastoma stage IV, hyperbaric oxygen and radioionated meta-Iodobenzylguanidine (MIBG) was used in a clinical setting. Although survival may not be used as a determinant of the usefulness of a treatment for stage IV neuroblastoma disease, a better one is not available. In this study, at 28 months, a cumulative probability of survival of 32% was recorded for patients treated with [ 131 I]MIBG and hyperbaric oxygen compared to 12% for [ 131 I]MIBG treatment alone. These preliminary results are promising but further studies are needed to reveal substantial therapeutic gain. (Author)

Hyperoxia decreases glycolytic capacity, glycolytic reserve and oxidative phosphorylation in MLE-12 cells and inhibits complex I and II function, but not complex IV in isolated mouse lung mitochondria.

Directory of Open Access Journals (Sweden)

Kumuda C Das

Full Text Available High levels of oxygen (hyperoxia are frequently used in critical care units and in conditions of respiratory insufficiencies in adults, as well as in infants. However, hyperoxia has been implicated in a number of pulmonary disorders including bronchopulmonary dysplasia (BPD and adult respiratory distress syndrome (ARDS. Hyperoxia increases the generation of reactive oxygen species (ROS in the mitochondria that could impair the function of the mitochondrial electron transport chain. We analyzed lung mitochondrial function in hyperoxia using the XF24 analyzer (extracellular flux and optimized the assay for lung epithelial cells and mitochondria isolated from lungs of mice. Our data show that hyperoxia decreases basal oxygen consumption rate (OCR, spare respiratory capacity, maximal respiration and ATP turnover in MLE-12 cells. There was significant decrease in glycolytic capacity and glycolytic reserve in MLE-12 cells exposed to hyperoxia. Using mitochondria isolated from lungs of mice exposed to hyperoxia or normoxia we have shown that hyperoxia decreased the basal, state 3 and state3 μ (respiration in an uncoupled state respirations. Further, using substrate or inhibitor of a specific complex we show that the OCR via complex I and II, but not complex IV was decreased, demonstrating that complexes I and II are specific targets of hyperoxia. Further, the activities of complex I (NADH dehydrogenase, NADH-DH and complex II (succinate dehydrogenase, SDH were decreased in hyperoxia, but the activity of complex IV (cytochrome oxidase, COX remains unchanged. Taken together, our study show that hyperoxia impairs glycolytic and mitochondrial energy metabolism in in tact cells, as well as in lungs of mice by selectively inactivating components of electron transport system.

EBR-II: summary of operating experience

International Nuclear Information System (INIS)

Perry, W.H.; Leman, J.D.; Lentz, G.L.; Longua, K.J.; Olson, W.H.; Shields, J.A.; Wolz, G.C.

1978-01-01

Experimental Breeder Reactor II (EBR-II) is an unmoderated, sodium-cooled reactor with a design power of 62.5 MWt. The primary cooling system is a submerged-pool type. The early operation of the reactor successfully demonstrated the feasibility of a sodium-cooled fast breeder reactor operating as an integrated reactor, power plant, and fuel-processing facility. In 1967, the role of EBR-II was reoriented from a demonstration plant to an irradiation facility. Many changes have been made and are continuing to be made to increase the usefulness of EBR-II for irradiation and safety tests. A review of EBR-II's operating history reveals a plant that has demonstrated high availability, stable and safe operating characteristics, and excellent performance of sodium components. Levels of radiation exposure to the operating and maintenance workers have been low; and fission-gas releases to the atmosphere have been minimal. Driver-fuel performance has been excellent. The repairability of radioactive sodium components has been successfully demonstrated a number of times. Recent highlights include installation and successful operation of (1) the hydrogen-meter leak detectors for the steam generators, (2) the cover-gas-cleanup system and (3) the cesium trap in the primary sodium. Irradiations now being conducted in EBR-II include the run-beyond-cladding breach fuel tests for mixed-oxide and carbide elements. Studies are in progress to determine EBR-II's capability for conducting important ''operational safety'' tests. These tests would extend the need and usefulness of EBR-II into the 1980's

Robust Requirements Tracing via Internet Search Technology: Improving an IV and V Technique. Phase 2

Science.gov (United States)

Hayes, Jane; Dekhtyar, Alex

2004-01-01

There are three major objectives to this phase of the work. (1) Improvement of Information Retrieval (IR) methods for Independent Verification and Validation (IV&V) requirements tracing. Information Retrieval methods are typically developed for very large (order of millions - tens of millions and more documents) document collections and therefore, most successfully used methods somewhat sacrifice precision and recall in order to achieve efficiency. At the same time typical IR systems treat all user queries as independent of each other and assume that relevance of documents to queries is subjective for each user. The IV&V requirements tracing problem has a much smaller data set to operate on, even for large software development projects; the set of queries is predetermined by the high-level specification document and individual requirements considered as query input to IR methods are not necessarily independent from each other. Namely, knowledge about the links for one requirement may be helpful in determining the links of another requirement. Finally, while the final decision on the exact form of the traceability matrix still belongs to the IV&V analyst, his/her decisions are much less arbitrary than those of an Internet search engine user. All this suggests that the information available to us in the framework of the IV&V tracing problem can be successfully leveraged to enhance standard IR techniques, which in turn would lead to increased recall and precision. We developed several new methods during Phase II; (2) IV&V requirements tracing IR toolkit. Based on the methods developed in Phase I and their improvements developed in Phase II, we built a toolkit of IR methods for IV&V requirements tracing. The toolkit has been integrated, at the data level, with SAIC's SuperTracePlus (STP) tool; (3) Toolkit testing. We tested the methods included in the IV&V requirements tracing IR toolkit on a number of projects.

Flow structure formation in an ion-unmagnetized plasma: The HYPER-II experiments

Science.gov (United States)

Terasaka, K.; Tanaka, M. Y.; Yoshimura, S.; Aramaki, M.; Sakamoto, Y.; Kawazu, F.; Furuta, K.; Takatsuka, N.; Masuda, M.; Nakano, R.

2015-01-01

The HYPER-II device has been constructed in Kyushu University to investigate the flow structure formation in an ion-unmagnetized plasma, which is an intermediate state of plasma and consists of unmagnetized ions and magnetized electrons. High density plasmas are produced by electron cyclotron resonance heating, and the flow field structure in an inhomogeneous magnetic field is investigated with a directional Langmuir probe method and a laser-induced fluorescence method. The experimental setup has been completed and the diagnostic systems have been installed to start the experiments. A set of coaxial electrodes will be introduced to control the azimuthal plasma rotation, and the effect of plasma rotation to generation of rectilinear flow structure will be studied. The HYPER-II experiments will clarify the overall flow structure in the inhomogeneous magnetic field and contribute to understanding characteristic feature of the intermediate state of plasma.

Studies of the effects of organic materials on the sorption of uranium(IV) and thorium(IV) on London clay and Caithness flagstones

International Nuclear Information System (INIS)

Baston, G.M.N.; Berry, J.A.; Bond, K.A.; Brownsword, M.; Linklater, C.M.

1991-08-01

The effects of the presence of cellulosic degradation products on the sorption of uranium (IV) and thorium(IV) on London clay and Caithness flagstones have been studied using the batch sorption method. Experimental conditions were chosen to simulate both those expected close to a cementitious repository (pH ∼11) and at the edge of the zone of migration of the alkaline plume (pH ∼ 8). Work was carried out (i) under baseline conditions, in the absence of organic materials; (ii) with 2 x 10 -3 M gluconate, acting as a well-characterised degradation product simulant; (iii) with authentic degradation products. The results show that the presence of authentic degradation products has a small effect on sorption and the presence of gluconate at a high concentration has a marked impact. (author)

Studies of the effects of organic materials on the sorption of uranium(IV) and thorium(IV) on London clay and Caithness flagstones

Energy Technology Data Exchange (ETDEWEB)

Baston, G.M.N.; Berry, J.A.; Bond, K.A.; Brownsword, M.; Linklater, C.M.

1991-08-01

The effects of the presence of cellulosic degradation products on the sorption of uranium (IV) and thorium(IV) on London clay and Caithness flagstones have been studied using the batch sorption method. Experimental conditions were chosen to simulate both those expected close to a cementitious repository (pH {approx}11) and at the edge of the zone of migration of the alkaline plume (pH {approx} 8). Work was carried out (i) under baseline conditions, in the absence of organic materials; (ii) with 2 x 10{sup -3}M gluconate, acting as a well-characterised degradation product simulant; (iii) with authentic degradation products. The results show that the presence of authentic degradation products has a small effect on sorption and the presence of gluconate at a high concentration has a marked impact. (author).

Fundamental insights into conformational stability and orbital interactions of antioxidant (+)-catechin species and complexation of (+)-catechin with zinc(II) and oxovanadium(IV)

Science.gov (United States)

Yasarawan, Nuttawisit; Thipyapong, Khajadpai; Sirichai, Somsak; Ruangpornvisuti, Vithaya

2013-09-01

Conformational stability of (+)-catechin species in water has been examined with density functional theory, associated with the polarizable continuum model (PCM) of solvation. Factors such as electron delocalization, lone-pair electron donation and intramolecular hydrogen bonding substantially contribute to the conformational stabilization. Upon deprotonation, the HOMO and LUMO energies for (+)-catechin are both elevated; the energy gaps for the deprotonated species are narrower than the energy gap for the neutral species. The preferential deprotonation occurs at the C3'-, C5-, C7- and C4'-OH groups successively. The pKa value at 9.3 predicted for the most acidic OH group agrees well with previous experimental data; however the values are overestimated for the less acidic OH groups due to limitations of the PCM for charged solutes and/or complex nature of true deprotonation pathways. Formation of hydrogen radicals should be promoted at high pH values following the bond dissociation enthalpies. Complexation of (+)-catechin with either zinc(II) or oxovanadium(IV) is favored at the 1:1 metal-to-ligand (M:L) mole ratio, with the oxovanadium(IV) complex showing higher reaction preference. At M:L = 1:2, formation of two isomeric complexes are plausible for each type of metal ion. Effects of stoichiometry and isomerism on the computational spectral features of the possibly formed metal complexes have been described.

La Historia de la Contabilidad, vía privilegiada de aproximación a la investigación histórica: Cuentas de los fondos recibidos por la Factoría General de los Reinos de España para financiar la guerra de Felipe II contra el Papa Pablo IV y Enrique II de Francia (1556-1559 PARTE 1

Directory of Open Access Journals (Sweden)

Esteban Hernández Esteve

2010-12-01

Full Text Available La Historia de la Contabilidad, vía privilegiada de aproximación a la investigación histórica: Cuentas de los fondos recibidos por la Factoría General de los Reinos de España para financiar la guerra de Felipe II contra el Papa Pablo IV y Enrique II de Francia (1556-1559 PARTE 1

Oxidation of sulfur (IV by oxygen in aqueous solution: role of some metal ions

Directory of Open Access Journals (Sweden)

Martins Claudia R.

1999-01-01

Full Text Available Catalytic effect of metal ions: Cr(VI, Cr(III, Cd(II, V(V and chloride anion, on the oxidation of S(IV in aqueous solution, at concentrations of metal ions and S(IV usually found in urban atmospheres, were studied under controlled experimental conditions (pH (2.1 - 4,5, T (25.0 - 35.0 °C, air flow rate, concentration of reactants, etc.... The kinetic constant determined at 25.0 °C and pH range (2.1 - 4.5, using ultra pure water was 8.0 ± 0.5 x 10-4 s-1. This value was considered as a reference for the oxidation reaction rate. The kinetic constants determined in the presence of Cr(VI revealed that the oxidation reaction of S(IV is quite influenced by the acidity. At pH = 2.1 (K = 2.3 x 10-2 mg-1 L s-1 the reaction is carried out with a rate five times greater when compared to pH = 2.6 (K = 4.3 x 10-3 mg-1 L s-1 and thirty times greater when compared to pH = 3.4 (K= 8.0 x 10 -4 mg-1 L s-1. The following rate expression was obtained at pH = 2.6: -r(S(IV =K [Cr(VI] [S(IV] and the activation energy found was: Ea =70.3KJ/mol. No catalytic effects were observed for Cd(II or chloride ion, while inhibitory effects were observed for Cr(III and V(V ions.

Ion exchange kinetics of alkaline earths on Zr(IV) arsenosilicate cation exchanger

International Nuclear Information System (INIS)

Varshney, K.G.; Agrawal, S.; Varshney, K.

1984-01-01

A new approach based on the Nernst-Planck equations was applied to study the ion exchange kinetics for the exchange reactions of Mg(II), Ca(II), Sr(II) and Ba(II) with H + -ions at various temperatures on the zirconium(IV) arsenosilicate phase. Under the conditions of particle diffusion, the rate of exchange was found to be independent of the metal ion concentration at and above 0.1 M in aqueous medium. Energy and entropy of activation were determined and found to vary linearly with the ionic radii and mobilities of alkaline earths, a unique feature observed for an inorganic ion exchanger. The results are useful for predicting the ion exchange processes occurring on the surface of an inorganic material of the type studied. (author)

A murine monoclonal anti-idiotypic antibody detects a common idiotope on human, mouse and rabbit antibodies to allergen Lol p IV.

Science.gov (United States)

Zhou, E M; Dzuba-Fischer, J M; Rector, E S; Sehon, A H; Kisil, F T

1991-09-01

A syngeneic mouse monoclonal anti-idiotypic antibody (anti-Id), designated as B1/1, was generated against a monoclonal antibody (MoAb 91) specific for Ryegrass pollen allergen Lol p IV. This anti-Id recognized an idiotope (Id) that was also present on other monoclonal antibodies with the same specificity as MoAb 91. Observations that (i) the anti-Id inhibited the binding of MoAb 91 to Lol p IV and (ii) the Id-anti-Id interaction could be inhibited by Lol p IV indicated that the Id was located within or near the antigen combining site. These properties served to characterize B1/1 as an internal image anti-Id. Evidence that an immune response in different species to Lol p IV elicits the formation of antibodies which express a common Id was provided by the observations that (i) the Id-anti-Id interactions could be inhibited by mouse, human and rabbit antisera to Lol p IV and (ii) the binding of these antisera to Lol p IV could be inhibited by the anti-Id. Interestingly, the internal image anti-Id B1/1 also recognized an Id on a monoclonal antibody which was directed to an epitope of Lol p IV, different from that recognized by MoAb 91.

ROLE OF DPP-IV INHIBITORS IN TREATMENT OF TYPE II DIABETES

OpenAIRE

Patel Kishan D; Patel Grishma M.

2010-01-01

Emerging as an epidemic of the 21st century type II diabetes has become a major health problem throughout the globe. Known treatments of type II diabetes mellitus have limitations such as weight gain and hypoglycaemias. A new perspective is the use of incretin hormones and incretin enhancers. Incretin mimetics are a new class of pharmacological agents with multiple antihyperglycemic actions that mimic the actions of incretin hormones such as glucagon-like peptide (GLP)-1. DPP-4, a protease th...

Interação entre Hb C [beta6(A3Glu>Lys] e IVS II-654 (C>T beta-talassemia no Brasil Hb C [beta6(A3Glu>Lys] and IVS II - 654 (C>T beta thalassemia interaction in Brazil

Directory of Open Access Journals (Sweden)

Claudia R. Bonini-Domingos

2003-06-01

Full Text Available Thalassemias are a heterogeneous group of inherited disorders characterized by a microcytic hypochromic anemia and an imbalance in the synthesis of the globin-chains. Hb C is the second most frequently variant of hemoglobin found in Brazil. The laboratory diagnosis of hemoglobinopathies, including thalassemias, is growing in importance, particularly because of an increasing requirement for neonatal diagnosis of abnormal hemoglobins. Screening tests were carried out using alkaline and acid electrophoresis, globin-chain analysis by cellulose acetate in alkaline pH, isoelectric focusing and HPLC. The molecular characterization was made by PCR-ASO for Hb C and beta thalassemia mutants. Large-scale screening and discriminative methodologies must provide information about the hemoglobin polymorphisms in Brazilian population. HPLC is a powerful tool in these cases. Molecular characterization is important to genetic counseling and clinical management, in particular for the Brazilian population that have an intense racial admixture, with great variability of hemoglobins. In this paper an association between Hb C and beta thalassemia (IVS-II-654 in a black family from Brazil was described.

On the Directivity of Low-Frequency Type IV Radio Bursts

Science.gov (United States)

Gopalswamy, N.; Akiyama, S.; Makela, P.; Yashiro, S.; Cairns, I. H.

2016-01-01

An intense type IV radio burst was observed by the STEREO Behind (STB) spacecraft located about 144 deg. behind Earth. The burst was associated with a large solar eruption that occurred on the backside of the Sun (N05E151) close to the disk center in the STB view. The eruption was also observed by the STEREO Ahead (STA) spacecraft (located at 149 deg. ahead of Earth) as an eruption close to the west limb (N05W60) in that view. The type IV burst was complete in STB observations in that the envelope reached the lowest frequency and then receded to higher frequencies. The burst was partial viewed from STA, revealing only the edge coming down to the lowest frequency. The type IV burst was not observed at all near Earth because the source was 61 deg. behind the east limb. The eruption was associated with a low-frequency type II burst observed in all three views, although it was not very intense. Solar energetic particles were also observed at both STEREOs and at SOHO, suggesting that the shock was much extended, consistent with the very high speed of the CME (2048 km/s). These observations suggest that the type IV emission is directed along a narrow cone above the flare site. We confirm this result statistically using the type IV bursts of solar cycle 23.

Contribution to the study of mechanisms of oxidation of uranium (IV) in solution

International Nuclear Information System (INIS)

Michaille, Patrick

1977-01-01

In the first part, the author reports a bibliographical study which aims at briefly describing the main parameters which govern redox kinetics between metallic ions in solution: acidity, complexing reaction by anions, solvent effects. The author also highlights existing contradictions and shortcomings in the interpretation of experimental results as well as in current theories, and highlights characteristics proper to uranium (IV). The author then describes results obtained for kinetics of Ce(IV)-U(IV) systems: effects of acidity, of sulphate, search for other anionic and cationic catalysts, influence of fluoride, inhibition by DMSO). Some of these results (influence of fluoride and DMSO) are compared with those obtained with the Ce(IV)-Fe(II) system. A more detailed study of the solvent role has been performed for the U(IV)-Fe(III) system in a mixed water-ethylene glycol medium and in pure glycol. The next part addresses the modifications of flow stopped spectrophotometry to solve problems of corrosion and bad temperature regulation. The author presents analog (kinetics) and digital (complexing equilibrium) calculation methods, and the development of colour indicators of temperature [fr

A Survey of Optometry Graduates to Determine Practice Patterns: Part II: Licensure and Practice Establishment Experiences.

Science.gov (United States)

Bleimann, Robert L.; Smith, Lee W.

1985-01-01

A summary of Part II of a two-volume study of optometry graduates conducted by the Association of Schools and Colleges of Optometry is presented. Part II includes the analysis of the graduates' licensure and practice establishment experiences. (MLW)

Synthesis of diorganoplatinum(IV) complexes by the Ssbnd S bond cleavage with platinum(II) complexes

Science.gov (United States)

Niroomand Hosseini, Fatemeh; Rashidi, Mehdi; Nabavizadeh, S. Masoud

2016-12-01

Reaction of [PtR2(NN)] (R = Me, p-MeC6H4 or p-MeOC6H4; NN = 2,2‧-bipyridine, 4,4‧-dimethyl-2,2‧-bipyridine, 1,10-phenanthroline or 2,9-dimethyl-1,10-phenanthroline) with MeSSMe gives the platinum(IV) complexes cis,trans-[PtR2(SMe)2(NN)]. They are characterized by NMR spectroscopy and elemental analysis. The geometries and the nature of the frontier molecular orbitals of Pt(IV) complexes containing Ptsbnd S bonds are studied by means of the density functional theory.

PLANS FOR WARM DENSE MATTER EXPERIMENTS AND IFE TARGET EXPERIMENTS ON NDCX-II

International Nuclear Information System (INIS)

Waldron, W.L.; Barnard, J.J.; Bieniosek, F.M.; Friedman, A.; Henestroza, E.; Leitner, M.; Logan, B.G.; Ni, P.A.; Roy, P.K.; Seidl, P.A.; Sharp, W.M.

2008-01-01

The Heavy Ion Fusion Science Virtual National Laboratory (HIFS-VNL) is currently developing design concepts for NDCX-II, the second phase of the Neutralized Drift Compression Experiment, which will use ion beams to explore Warm Dense Matter (WDM) and Inertial Fusion Energy (IFE) target hydrodynamics. The ion induction accelerator will consist of a new short pulse injector and induction cells from the decommissioned Advanced Test Accelerator (ATA) at Lawrence Livermore National Laboratory (LLNL). To fit within an existing building and to meet the energy and temporal requirements of various target experiments, an aggressive beam compression and acceleration schedule is planned. WDM physics and ion-driven direct drive hydrodynamics will initially be explored with 30 nC of lithium ions in experiments involving ion deposition, ablation, acceleration and stability of planar targets. Other ion sources which may deliver higher charge per bunch will be explored. A test stand has been built at Lawrence Berkeley National Laboratory (LBNL) to test refurbished ATA induction cells and pulsed power hardware for voltage holding and ability to produce various compression and acceleration waveforms. Another test stand is being used to develop and characterize lithium-doped aluminosilicate ion sources. The first experiments will include heating metallic targets to 10,000 K and hydrodynamics studies with cryogenic hydrogen targets

Analysis of responses to angiotensin II in the mouse

Directory of Open Access Journals (Sweden)

Trinity J Bivalacqua

2001-03-01

Full Text Available Responses to angiotensin II (Ang II were investigated in anaesthetised CD1 mice. Injections of Ang II caused dose-related increases in systemic arterial pressure that were antagonised by candesartan. Responses to Ang II were not altered by PD 123319. At the lowest dose studied (20 µg/kg i.v., the inhibitory effects of candesartan were competitive, whereas at the highest dose (100 µg/kg i.v., the dose-response curve for Ang II was shifted to the right in a non-parallel manner. The inhibitory effects of candesartan were selective and were similar in animals pretreated with enalaprilat to reduce endogenous Ang II production. Pressor responses to Ang II were not altered by propranolol, phentolamine or atropine, but were enhanced by hexamethonium. Increases in total peripheral resistance were inhibited by the AT1-receptor antagonist (ARB but were not altered by AT2-receptor, alpha- or beta-receptor antagonists. These results suggest that pressor responses to Ang II are mediated by AT 1-receptors, are buffered by the baroreceptors, are not modulated by effects on AT2receptors, and that activation of the sympathetic nervous system plays little role in mediating rapid haemodynamic responses to the peptide in anaesthetised mice.

Mn(II,III) oxidation and MnO2 mineralization by an expressed bacterial multicopper oxidase

Science.gov (United States)

Butterfield, Cristina N.; Soldatova, Alexandra V.; Lee, Sung-Woo; Spiro, Thomas G.; Tebo, Bradley M.

2013-01-01

Reactive Mn(IV) oxide minerals are ubiquitous in the environment and control the bioavailability and distribution of many toxic and essential elements and organic compounds. Their formation is thought to be dependent on microbial enzymes, because spontaneous Mn(II) to Mn(IV) oxidation is slow. Several species of marine Bacillus spores oxidize Mn(II) on their exosporium, the outermost layer of the spore, encrusting them with Mn(IV) oxides. Molecular studies have identified the mnx (Mn oxidation) genes, including mnxG, encoding a putative multicopper oxidase (MCO), as responsible for this two-electron oxidation, a surprising finding because MCOs only catalyze single-electron transfer reactions. Characterization of the enzymatic mechanism has been hindered by the lack of purified protein. By purifying active protein from the mnxDEFG expression construct, we found that the resulting enzyme is a blue (absorption maximum 590 nm) complex containing MnxE, MnxF, and MnxG proteins. Further, by analyzing the Mn(II)- and (III)-oxidizing activity in the presence of a Mn(III) chelator, pyrophosphate, we found that the complex facilitates both electron transfers from Mn(II) to Mn(III) and from Mn(III) to Mn(IV). X-ray absorption spectroscopy of the Mn mineral product confirmed its similarity to Mn(IV) oxides generated by whole spores. Our results demonstrate that Mn oxidation from soluble Mn(II) to Mn(IV) oxides is a two-step reaction catalyzed by an MCO-containing complex. With the purification of active Mn oxidase, we will be able to uncover its mechanism, broadening our understanding of Mn mineral formation and the bioinorganic capabilities of MCOs. PMID:23818588

Electrically Driven Thermal Management: Flight Validation, Experiment Development, Future Technologies

Science.gov (United States)

Didion, Jeffrey R.

2018-01-01

Electrically Driven Thermal Management is an active research and technology development initiative incorporating ISS technology flight demonstrations (STP-H5), development of Microgravity Science Glovebox (MSG) flight experiment, and laboratory-based investigations of electrically based thermal management techniques. The program targets integrated thermal management for future generations of RF electronics and power electronic devices. This presentation reviews four program elements: i.) results from the Electrohydrodynamic (EHD) Long Term Flight Demonstration launched in February 2017 ii.) development of the Electrically Driven Liquid Film Boiling Experiment iii.) two University based research efforts iv.) development of Oscillating Heat Pipe evaluation at Goddard Space Flight Center.

The MUSCLES Treasury Survey. IV. Scaling Relations for Ultraviolet, Ca II K, and Energetic Particle Fluxes from M Dwarfs

Science.gov (United States)

Youngblood, Allison; France, Kevin; Loyd, R. O. Parke; Brown, Alexander; Mason, James P.; Schneider, P. Christian; Tilley, Matt A.; Berta-Thompson, Zachory K.; Buccino, Andrea; Froning, Cynthia S.; Hawley, Suzanne L.; Linsky, Jeffrey; Mauas, Pablo J. D.; Redfield, Seth; Kowalski, Adam; Miguel, Yamila; Newton, Elisabeth R.; Rugheimer, Sarah; Segura, Antígona; Roberge, Aki; Vieytes, Mariela

2017-07-01

Characterizing the UV spectral energy distribution (SED) of an exoplanet host star is critically important for assessing its planet’s potential habitability, particularly for M dwarfs, as they are prime targets for current and near-term exoplanet characterization efforts and atmospheric models predict that their UV radiation can produce photochemistry on habitable zone planets different from that on Earth. To derive ground-based proxies for UV emission for use when Hubble Space Telescope (HST) observations are unavailable, we have assembled a sample of 15 early to mid-M dwarfs observed by HST and compared their nonsimultaneous UV and optical spectra. We find that the equivalent width of the chromospheric Ca II K line at 3933 Å, when corrected for spectral type, can be used to estimate the stellar surface flux in ultraviolet emission lines, including H I Lyα. In addition, we address another potential driver of habitability: energetic particle fluxes associated with flares. We present a new technique for estimating soft X-ray and >10 MeV proton flux during far-UV emission line flares (Si IV and He II) by assuming solar-like energy partitions. We analyze several flares from the M4 dwarf GJ 876 observed with HST and Chandra as part of the MUSCLES Treasury Survey and find that habitable zone planets orbiting GJ 876 are impacted by large Carrington-like flares with peak soft X-ray fluxes ≥10-3 W m-2 and possible proton fluxes ˜102-103 pfu, approximately four orders of magnitude more frequently than modern-day Earth.

The MUSCLES Treasury Survey. IV. Scaling Relations for Ultraviolet, Ca ii K, and Energetic Particle Fluxes from M Dwarfs

International Nuclear Information System (INIS)

Youngblood, Allison; France, Kevin; Loyd, R. O. Parke; Mason, James P.; Brown, Alexander; Schneider, P. Christian; Tilley, Matt A.; Berta-Thompson, Zachory K.; Kowalski, Adam; Buccino, Andrea; Mauas, Pablo J. D.; Froning, Cynthia S.; Hawley, Suzanne L.; Linsky, Jeffrey; Redfield, Seth; Miguel, Yamila; Newton, Elisabeth R.; Rugheimer, Sarah

2017-01-01

Characterizing the UV spectral energy distribution (SED) of an exoplanet host star is critically important for assessing its planet’s potential habitability, particularly for M dwarfs, as they are prime targets for current and near-term exoplanet characterization efforts and atmospheric models predict that their UV radiation can produce photochemistry on habitable zone planets different from that on Earth. To derive ground-based proxies for UV emission for use when Hubble Space Telescope ( HST ) observations are unavailable, we have assembled a sample of 15 early to mid-M dwarfs observed by HST and compared their nonsimultaneous UV and optical spectra. We find that the equivalent width of the chromospheric Ca ii K line at 3933 Å, when corrected for spectral type, can be used to estimate the stellar surface flux in ultraviolet emission lines, including H i Ly α . In addition, we address another potential driver of habitability: energetic particle fluxes associated with flares. We present a new technique for estimating soft X-ray and >10 MeV proton flux during far-UV emission line flares (Si iv and He ii) by assuming solar-like energy partitions. We analyze several flares from the M4 dwarf GJ 876 observed with HST and Chandra as part of the MUSCLES Treasury Survey and find that habitable zone planets orbiting GJ 876 are impacted by large Carrington-like flares with peak soft X-ray fluxes ≥10 −3 W m −2 and possible proton fluxes ∼10 2 –10 3 pfu, approximately four orders of magnitude more frequently than modern-day Earth.

Test Review: Advanced Clinical Solutions for WAIS-IV and WMS-IV

Science.gov (United States)

Chu, Yiting; Lai, Mark H. C.; Xu, Yining; Zhou, Yuanyuan

2012-01-01

The authors review the "Advanced Clinical Solutions for WAIS-IV and WMS-IV". The "Advanced Clinical Solutions (ACS) for the Wechsler Adult Intelligence Scale-Fourth Edition" (WAIS-IV; Wechsler, 2008) and the "Wechsler Memory Scale-Fourth Edition" (WMS-IV; Wechsler, 2009) was published by Pearson in 2009. It is a…

Latest experience on insertion devices at the National Synchrotron Light Source-II

International Nuclear Information System (INIS)

Tanabe, Toshiya; Cappadoro, Peter; Corwin, Todd

2016-01-01

National Synchrotron Light Source-II (NSLS-II) is the latest storage ring of 3 GeV energy with the horizontal emittance of the electron beam being 0.9 nm.rad. Nine In-Vacuum Undulators (IVUs) are utilized at the NSLS-II as of February 2016. All IVUs have a unique side window derived from the experience from the CHESS facility in Cornell University. An R and D activity called 'Vacuum Seal Test' was conducted to ensure the viability of aluminum wire seal. Another R and D activity to develop a measurement system for Cryogenic Permanent Magnet Undulator (CPMU) was also performed. Other in-air devices, namely damping wigglers (DWs) and elliptically polarizing undulators (EPUs) utilize extruded aluminum chambers with Non-Evaporable Getter (NEG) coating. The beam-based integral estimates were obtained from the virtual kicks at the upstream and downstream of the undulator that best fit the measured orbit distortion in a model lattice with Tracy. In some cases, there are fairly large discrepancies between magnetic measurement data and observed integrals by the beam. Beam studies were carried out to explain the discrepancies mentioned earlier. The latest experiences on ID development and commissioning are discussed in conjunction with related activities in the world. (author)

Exogenous L-Arginine Attenuates the Effects of Angiotensin II on Renal Hemodynamics and the Pressure Natriuresis-Diuresis Relationship

Science.gov (United States)

Das, Satarupa; Mattson, David L.

2014-01-01

SUMMARY Administration of exogenous L-Arginine (L-Arg) attenuates Angiotensin II (AngII)-mediated hypertension and kidney disease in rats. The present study assessed renal hemodynamics and pressure-diuresis-natriuresis in anesthetized rats infused with vehicle, AngII (20 ng/kg/min, iv) or AngII + L-Arg (300 µg/kg/min, iv). Increasing renal perfusion pressure (RPP) from approximately 100 to 140 mmHg resulted in a 9–10 fold increase in urine flow and sodium excretion rate in control animals. In comparison, AngII infusion significantly reduced renal blood flow (RBF) and glomerular filtration rate (GFR) by 40–42% and blunted the pressure-dependent increase in urine flow and sodium excretion rate by 54–58% at elevated RPP. Supplementation of L-Arg reversed the vasoconstrictor effects of AngII and restored pressure-dependent diuresis to levels not significantly different from control rats. Experiments in isolated aortic rings were performed to assess L-Arg effects on the vasculature. Dose-dependent contraction to AngII (10−10M to 10−7M) was observed with a maximal force equal to 27±3% of the response to 10−5M phenylephrine. Contraction to 10−7M AngII was blunted by 75±3% with 10−4M L-Arg. The influence of L-Arg to blunt AngII mediated contraction was eliminated by endothelial denudation or incubation with nitric oxide synthase inhibitors. Moreover, the addition of 10−3M cationic or neutral amino acids, which compete with L-Arg for cellular uptake, blocked the effect of L-Arg. Anionic amino acids did not influence the effects of L-Arg on AngII-mediated contraction. These studies indicate that L-Arg blunts AngII-mediated vascular contraction by an endothelial- and NOS-dependent mechanism involving cellular uptake of L-Arg. PMID:24472006

Commissioning and performance studies of a proton recoil detector at the COMPASS-II experiment

Energy Technology Data Exchange (ETDEWEB)

Joerg, Philipp; Buechele, Maximilian; Fischer, Horst; Gorzellik, Matthias; Grussenmeyer, Tobias; Herrmann, Florian; Koenigsmann, Kay; Kremser, Paul; Schopferer, Sebastian [Physikalisches Institut, Albert-Ludwigs-Universitaet Freiburg (Germany); Collaboration: COMPASS Collaboration

2014-07-01

The COMPASS-II experiment is a fixed target experiment situated at CERN. A tertiary myon beam from the SPS scattered of protons from a liquid hydrogen target is used to measure Deeply Virtual Compton Scattering (DVCS) and Hard Exclusive Meson Production (HEMP). These processes offer a unique way to determine Generalized Parton Distributions, which are related to the total angular momentum of quarks, antiquarks and gluons in the nucleon by Ji's Sum Rule. One of the major parts of the COMPASS-II upgrade is the CAMERA detector. CAMERA is a proton recoil detector surrounding the COMPASS-II liquid hydrogen target. Its purpose is to measure the recoiled target proton in DVCS and HEMP reactions and viz to act as a veto to ensure the exclusivity of the measurement. The talk gives an outline of the detector and its readout electronics. It is focused on the commissioning and performance of the CAMERA detector and gives a brief insight into the ongoing DVCS analysis.

Photoactivation of Diiodido-Pt(IV) Complexes Coupled to Upconverting Nanoparticles.

Science.gov (United States)

Perfahl, Stefanie; Natile, Marta M; Mohamad, Heba S; Helm, Christiane A; Schulzke, Carola; Natile, Giovanni; Bednarski, Patrick J

2016-07-05

The preparation, characterization, and surface modification of upconverting lanthanide-doped hexagonal NaGdF4 nanocrystals attached to light sensitive diiodido-Pt(IV) complexes is presented. The evaluation for photoactivation and cytotoxicity of the novel carboxylated diiodido-Pt(IV) cytotoxic prodrugs by near-infrared (NIR) light (λ = 980 nm) is also reported. We attempted two different strategies for attachment of light-sensitive diiodido-Pt(IV) complexes to Yb,Er- and Yb,Tm-doped β-NaGdF4 upconverting nanoparticles (UCNPs) in order to provide nanohybrids, which offer unique opportunities for selective drug activation within the tumor cells and subsequent spatiotemporal controlled drug release by NIR-to-visible light-upconversion: (A) covalent attachment of the Pt(IV) complex via amide bond formation and (B) carboxylate exchange of oleate on the surface of the UCNPs with diiodido-Pt(IV) carboxylato complexes. Initial feasibility studies showed that NIR applied by a 980 nm laser had only a slight effect on the stability of the various diiodido-Pt(IV) complexes, but when UCNPs were present more rapid loss of the ligand-metal-charge transfer (LMCT) bands of the diiodido-Pt(IV) complexes was observed. Furthermore, Pt released from the Pt(IV) complexes platinated calf-thymus DNA (ct-DNA) more rapidly when NIR was applied compared to dark controls. Of the two attachment strategies, method A with the covalently attached diiodido-Pt(IV) carboxylates via amide bond formation proved to be the most effective method for generating UCNPs that release Pt when irradiated with NIR; the released Pt was also able to bind irreversibly to calf thymus DNA. Nonetheless, only ca. 20% of the Pt on the surface of the UCNPs was in the Pt(IV) oxidation state, the rest was Pt(II), indicating chemical reduction of the diiodido-Pt(IV) prodrug by the UCNPs. Cytotoxicity studies with the various UCNP-Pt conjugates and constructs, tested on human leukemia HL60 cells in culture, indicated a

Readability and Content Assessment of Informed Consent Forms for Phase II-IV Clinical Trials in China.

Science.gov (United States)

Wen, Gaiyan; Liu, Xinchun; Huang, Lihua; Shu, Jingxian; Xu, Nana; Chen, Ruifang; Huang, Zhijun; Yang, Guoping; Wang, Xiaomin; Xiang, Yuxia; Lu, Yao; Yuan, Hong

2016-01-01

To explore the readability and content integrity of informed consent forms (ICFs) used in China and to compare the quality of Chinese local ICFs with that of international ICFs. The length, readability and content of 155 consent documents from phase II-IV drug clinical trials from the Third Xiangya Hospital Ethics Committee from November 2009 to January 2015 were evaluated. Reading difficulty was tested using a readability formula adapted for the Chinese language. An ICF checklist containing 27 required elements was successfully constructed to evaluate content integrity. The description of alternatives to participation was assessed. The quality of ICFs from different sponsorships were also compared. Among the 155 evaluable trials, the ICFs had a median length of 5286 words, corresponding to 7 pages. The median readability score was 4.31 (4.02-4.41), with 63.9% at the 2nd level and 36.1% at the 3rd level. Five of the 27 elements were frequently neglected. The average score for the description of alternatives to participation was 1.06, and 27.7% of the ICFs did not mention any alternatives. Compared with Chinese local ICFs, international ICFs were longer, more readable and contained more of the required elements (P readability and content integrity than Chinese local ICFs. More efforts should thus be made to improve the quality of consent documents in China.

Direct complexonometric determination of thorium (IV), uranium (IV), neptunium (IV), plutonium (IV) by titration of diethylenetriaminepentaacetic acid with xylenol orange as indicator

International Nuclear Information System (INIS)

Rykov, A.G.; Piskunov, E.M.; Timofeev, G.A.

1975-01-01

The purpose of the present work was to develop a method of determining Th(IV), U(IV), Np(N) and Pu(IV) in acid solutions by titration with diethylenetriamine pentacetic acid, the indicator being xylenol orange. It has been established that Th, U, Np and Pu can be determined to within 0.5-1.5%. Th and U in quantities of tens of milligrams can be determined with greater accuracy, attaining hundredths of one per cent. During titration the determination is not hindered by singly- and doubly-charged metal ions, trivalent lanthanides and actinides, except plutonium. The proposed method can be used to determine U(IV) in the presence of considerable quantities of U(VI) and Np(IV) in the presence of Np(V). Total concentrations of uranium or neptunium are determined by reducing uranium (VI) or neptunium (V) by a standard method (for example, using metallic lead, cadmium or zinc amalgam) to the tetravalent state and applying the method described in the paper. (E.P.)

Processing data collected from radiometric experiments by multivariate technique

International Nuclear Information System (INIS)

Urbanski, P.; Kowalska, E.; Machaj, B.; Jakowiuk, A.

2005-01-01

Multivariate techniques applied for processing data collected from radiometric experiments can provide more efficient extraction of the information contained in the spectra. Several techniques are considered: (i) multivariate calibration using Partial Least Square Regression and Artificial Neural Network, (ii) standardization of the spectra, (iii) smoothing of collected spectra were autocorrelation function and bootstrap were used for the assessment of the processed data, (iv) image processing using Principal Component Analysis. Application of these techniques is illustrated on examples of some industrial applications. (author)

Formation of hydrothermal tin deposits: Raman spectroscopic evidence for an important role of aqueous Sn(IV) species

Science.gov (United States)

Schmidt, Christian

2018-01-01

The speciation of tin and the solubility of cassiterite in H2O + HCl were determined at temperatures to 600 °C using in situ Raman spectroscopy. In addition, information on the fluid-melt partition of Sn was obtained at 700 °C and indicated a preference of the fluid only at HCl concentrations that are much higher than in fluids exsolved from natural felsic melts. Dissolution of cassiterite generally resulted in formation of Sn(IV) species unless reduced conditions were generated by hydrogen permeation or carbohydrates in the starting material. The prevalent aqueous Sn(IV) species was [SnCl4(H2O)2]0, with additional [SnCl3(H2O)3]+ and [SnCl5(H2O)]-. The only detectable Sn(II) species was very likely [Sn(II)Cl3]-. Cassiterite solubility increased with HCl concentration and was generally high in H2O+HCl fluids, with no strong dependencies on temperature, pressure, or the oxidation state of tin in the fluid. The Sn(IV) concentrations at 500 and 600 °C determined from the integrated ν1[Sn(IV)sbnd Cl] band intensity are in good agreement with literature data on the cassiterite solubility in H2O + HCl at oxygen fugacities along the hematite-magnetite buffer. The combined results from previous experimental studies and this study demonstrate that HCl molality is a crucial parameter for hydrothermal mobilization and transport of tin and for cassiterite precipitation, and that pH, pressure and temperature are less important. Current models on hydrothermal tin deposit formation need to be augmented to include Sn(IV)sbnd Cl complexes as significant tin-transporting species. Irrespective of the oxidation state of tin in the fluid, cassiterite precipitates due to reaction of the hydrothermal fluid with the wall rock (greisen or skarn formation), dilution (mixing with meteoric water) or a decrease in the HCl activity in the aqueous liquid by boiling. A redox reaction is only required for tin transported as Sn(II) to be converted to Sn(IV).

Immobilization of 99-Technetium (VII) by Fe(II)-Goethite and Limited Reoxidation

International Nuclear Information System (INIS)

Um, Wooyong; Chang, Hyun-Shik; Icenhower, Jonathan P.; Lukens, Wayne W.; Serne, R. Jeffrey; Qafoku, Nikolla; Westsik, Joseph H.; Buck, Edgar C.; Smith, Steven C.

2011-01-01

Synthesized goethite was successfully used with addition of Fe(II) to sequester Tc present in both deionized water and simulated off-gas scrubber waste solutions. Pertechnetate concentration in solution decreased immediately when the pH was raised above 7 by addition of sodium hydroxide. Removal of Tc(VII) from solution occurred most likely as a result of heterogeneous surface-catalyzed reduction to Tc(IV) and subsequent co-precipitation onto the goethite. The final Tc-bearing solid was identified as goethite-dominated Fe(III)-(oxy)hydroxide based on XRD analysis, confirming the widespread observation of its characteristic acicular habit by TEM/SEM images. Analysis of the solid precipitate by XAFS showed that the dominant oxidation state of Tc was Tc(IV) and was in octahedral coordination with Tc-O, Fe-O, and Tc-Fe bond distances that are consistent with direct substitution of Tc for Fe in the goethite structure. In some experiments the final Tc-goethite product was subsequently armored with additional layers of freshly precipitated goethite. Successful incorporation of Tc(IV) within the goethite mineral lattice and subsequent goethite armoring can limit re-oxidation of Tc(IV) and its subsequent release from Tc-goethite waste forms, even when the final product is placed in oxidizing environments that typify shallow waste burial facilities.

The cryogenic photon detection system for the ALPS II experiment. Characterization, optimization and background rejection

Energy Technology Data Exchange (ETDEWEB)

Bastidon, Noemi Alice Chloe

2017-01-12

The search for new fundamental bosons at very low mass is the central objective of the ALPS II experiment which is currently set up at the Deutsches Elektronen-Synchrotron (DESY, Hamburg). This experiment follows the light-shining-through-the-wall concept where photons could oscillate into weakly interacting light bosons in front of a wall and back into photons behind the wall, giving the impression that light can shine through a light tight barrier. In this concept, the background-free detection of near-infrared photons is required to fully exploit the sensitivity of the apparatus. The high efficiency single-photon detection in the near-infrared is challenging and requires a cryogenic detector. In this project, a Transition-Edge Sensor (TES) operated below 100mK will be used to detect single photons. This thesis focuses on the characterization and optimization of the ALPS II detector system including an Adiabatic Demagnetisation Refrigerator (ADR) with its two-stage pulse-tube cooler, two TES detectors and their Superconducting Quantum Interference Devices (SQUIDs) read-out system. Stability of the detection system over time is a priority in the ALPS II experiment. It is in this context that the cooling system has been subjected to many upgrades. In the framework of this thesis, the cooling setup has been studied in detail in order to optimize its cooling performances. Furthermore, the stability of the detector has been studied according to various criteria. Other essential parameters of the ALPS II experiment are its detection efficiency and its background rate. Indeed, the sensitivity of the experiment directly depends on these two characteristics. Both elements have been studied in depth in order to define if the chosen TES detector will meet ALPS IIc specifications.

The cryogenic photon detection system for the ALPS II experiment. Characterization, optimization and background rejection

International Nuclear Information System (INIS)

Bastidon, Noemi Alice Chloe

2017-01-01

The search for new fundamental bosons at very low mass is the central objective of the ALPS II experiment which is currently set up at the Deutsches Elektronen-Synchrotron (DESY, Hamburg). This experiment follows the light-shining-through-the-wall concept where photons could oscillate into weakly interacting light bosons in front of a wall and back into photons behind the wall, giving the impression that light can shine through a light tight barrier. In this concept, the background-free detection of near-infrared photons is required to fully exploit the sensitivity of the apparatus. The high efficiency single-photon detection in the near-infrared is challenging and requires a cryogenic detector. In this project, a Transition-Edge Sensor (TES) operated below 100mK will be used to detect single photons. This thesis focuses on the characterization and optimization of the ALPS II detector system including an Adiabatic Demagnetisation Refrigerator (ADR) with its two-stage pulse-tube cooler, two TES detectors and their Superconducting Quantum Interference Devices (SQUIDs) read-out system. Stability of the detection system over time is a priority in the ALPS II experiment. It is in this context that the cooling system has been subjected to many upgrades. In the framework of this thesis, the cooling setup has been studied in detail in order to optimize its cooling performances. Furthermore, the stability of the detector has been studied according to various criteria. Other essential parameters of the ALPS II experiment are its detection efficiency and its background rate. Indeed, the sensitivity of the experiment directly depends on these two characteristics. Both elements have been studied in depth in order to define if the chosen TES detector will meet ALPS IIc specifications.

The Prognostic and Predictive Value of Soluble Type IV Collagen in Colorectal Cancer

DEFF Research Database (Denmark)

Rolff, Hans Christian; Christensen, Ib Jarle; Vainer, Ben

2016-01-01

PURPOSE: To investigate the prognostic and predictive biomarker value of type IV collagen in colorectal cancer. EXPERIMENTAL DESIGN: Retrospective evaluation of two independent cohorts of patients with colorectal cancer included prospectively in 2004-2005 (training set) and 2006-2008 (validation....... RESULTS: High levels of type IV collagen showed independent prognostic significance in both cohorts with hazard ratios (HRs; for a one-unit change on the log base 2 scale) of 2.25 [95% confidence intervals (CIs), 1.78-2.84; P ... and validation set, respectively. The prognostic impact was present both in patients with metastatic and nonmetastatic disease. The predictive value of the marker was investigated in stage II and III patients. In the training set, type IV collagen was prognostic both in the subsets of patients receiving...

The Ability of the Acute Physiology and Chronic Health Evaluation (APACHE IV Score to Predict Mortality in a Single Tertiary Hospital

Directory of Open Access Journals (Sweden)

Jae Woo Choi

2017-08-01

Full Text Available Background The Acute Physiology and Chronic Health Evaluation (APACHE II model has been widely used in Korea. However, there have been few studies on the APACHE IV model in Korean intensive care units (ICUs. The aim of this study was to compare the ability of APACHE IV and APACHE II in predicting hospital mortality, and to investigate the ability of APACHE IV as a critical care triage criterion. Methods The study was designed as a prospective cohort study. Measurements of discrimination and calibration were performed using the area under the receiver operating characteristic curve (AUROC and the Hosmer-Lemeshow goodness-of-fit test respectively. We also calculated the standardized mortality ratio (SMR. Results The APACHE IV score, the Charlson Comorbidity index (CCI score, acute respiratory distress syndrome, and unplanned ICU admissions were independently associated with hospital mortality. The calibration, discrimination, and SMR of APACHE IV were good (H = 7.67, P = 0.465; C = 3.42, P = 0.905; AUROC = 0.759; SMR = 1.00. However, the explanatory power of an APACHE IV score >93 alone on hospital mortality was low at 44.1%. The explanatory power was increased to 53.8% when the hospital mortality was predicted using a model that considers APACHE IV >93 scores, medical admission, and risk factors for CCI >3 coincidentally. However, the discriminative ability of the prediction model was unsatisfactory (C index <0.70. Conclusions The APACHE IV presented good discrimination, calibration, and SMR for hospital mortality.

[Clinic significance of nm23, collage IV and PCNA expression in non-small cell lung cancer].

Science.gov (United States)

Yu, Q; Ma, L; Jing, S; Xu, Y; Geng, D

2001-12-20

To study the significance of nm23, collagen IV and PCNA expressions in non-small cell lung cancer. Expressions of the nm23, collagen IV and PCNA in 84 cases of non-small cell lung cancer were examined with SP immunohistochemical technique. Of the 84 cases, there were squamous cell carcinoma 42, adenocarcinoma 42, stage I 27, stage II 24, stage III 24, and stage IV 9. Statistical analysis was performed with Chi-Square test. Expressions of the nm23, collagen IV and PCNA in 84 cases of non-small cell lung cancer were 60. 7% ( 51/ 84) , 75. 0% ( 63/ 84) and 53. 6% ( 45/ 84) respectively. There was negative correlation between the lymph node metastasis and the expressions of nm23 and collagen IV in squamous cell carcinoma, and the expressions of collagen IV and PCNA were associated with tumor differentiation. No correlation was found between TNM stage and expressions of nm23, collagen IV and PCNA. The results indicate that nm23, collagen IV and PCNA participate the modulation of metastasis of non-small cell lung cancer and that they may be used to evaluate the potential of metastasis.

Solution and surface chemistry of the Se(IV)-Fe(0) reactions: Effect of initial solution pH.

Science.gov (United States)

Xia, Xuefen; Ling, Lan; Zhang, Wei-Xian

2017-02-01

Aspects of solution and solid-phase reactions between selenite (Se(IV)) and nanoscale zero-valent iron (nZVI) were investigated. Experimental results on the effects of initial solution pH, formation and evolution of nZVI corrosion products, and speciation of selenium in nZVI were presented. In general, the rate of Se(IV) removal decreases with increasing initial pH. The observed rate constants of Se(IV) removal decreased from 0.3530 to 0.0364 min -1 as pH increased from 4.0 to 10.0. Composition and morphology of nZVI corrosion products and selenium species were characterized using scanning electron microscopy (SEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). Results confirmed that Se(IV) was reduced to Se(0) and Se(-II) by nZVI. Lower solution pH favored further reduction of Se(0) to Se(-II). Amorphous FeOOH, magnetite/maghemite (Fe 3 O 4 /γ-Fe 2 O 3 ) and ferrous hydroxide (Fe(OH) 2 ) were identified as the main corrosion products. Under alkaline conditions, the corrosion products were mainly of Fe(OH) 2 along with small amounts of Fe 3 O 4 , while nZVI in acidic solutions was oxidized to mostly Fe 3 O 4 and amorphous FeOOH. Furthermore, these corrosion products acted as intermediates for electron transfer and reactive/sorptive sites for Se(IV) adsorption and reduction, thus played a crucial role in the removal of aqueous Se(IV). Copyright © 2016. Published by Elsevier Ltd.

Efficient generation of volatile cadmium species using Ti(III) and Ti(IV) and application to determination of cadmium by cold vapor generation inductively coupled plasma mass spectrometry (CVG-ICP-MS)†

Science.gov (United States)

Arslan, Zikri; Yilmaz, Vedat; Rose, LaKeysha

2015-01-01

In this study, a highly efficient chemical vapor generation (CVG) approach is reported for determination of cadmium (Cd). Titanium (III) and titanium (IV) were investigated for the first time as catalytic additives along with thiourea, L-cysteine and potassium cyanide (KCN) for generation of volatile Cd species. Both Ti(III) and Ti(IV) provided the highest enhancement with KCN. The improvement with thiourea was marginal (ca. 2-fold), while L-cysteine enhanced signal slightly only with Ti(III) in H2SO4. Optimum CVG conditions were 4% (v/v) HCl + 0.03 M Ti(III) + 0.16 M KCN and 2% (v/v) HNO3 + 0.03 M Ti(IV) + 0.16 M KCN with a 3% (m/v) NaBH4 solution. The sensitivity was improved about 40-fold with Ti(III) and 35-fold with Ti(IV). A limit of detection (LOD) of 3.2 ng L−1 was achieved with Ti(III) by CVG-ICP-MS. The LOD with Ti(IV) was 6.4 ng L−1 which was limited by the blank signals in Ti(IV) solution. Experimental evidence indicated that Ti(III) and Ti(IV) enhanced Cd vapor generation catalytically; for best efficiency mixing prior to reaction with NaBH4 was critical. The method was highly robust against the effects of transition metal ions. No significant suppression was observed in the presence of Co(II), Cr(III), Cu(II), Fe(III), Mn(II), Ni(II) and Zn(II) up to 1.0 μg mL−1. Among the hydride forming elements, no interference was observed from As(III) and Se(IV) at 0.5 μg mL−1 level. The depressive effects from Pb(II) and Sb(III) were not significant at 0.1 μg mL−1 while those from Bi(III) and Sn(II) were marginal. The procedures were validated with determination of Cd by CVG-ICP-MS in a number certified reference materials, including Nearshore seawater (CASS-4), Bone ash (SRM 1400), Dogfish liver (DOLT-4), Mussel tissue (SRM 2976) and Domestic Sludge (SRM 2781). PMID:26251554

Emergence of group B Streptococcus serotype IV in women of child-bearing age in Ireland.

LENUS (Irish Health Repository)

Kiely, R A

2011-02-01

This study determined the carriage rate and serotype distribution of group B Streptococcus (GBS) in women of child-bearing age in the southern region of Ireland. A total of 2000 vaginal swabs collected in two periods in 2004 and 2006 were examined and revealed a GBS carriage rate of 16·1%. Serotyping of isolates showed that serotypes Ia, II, III, IV, and V were the most prevalent. A high prevalence of serotype IV was found, increasing from 7·6% to 15·2% between 2004 and 2006. Random amplified polymorphic DNA analysis demonstrated considerable genetic heterogeneity in the serotype IV isolates. This serotype should be considered for inclusion in potential vaccines for use in Ireland.

IPROP simulations of the GAMBLE II proton transport experiment

International Nuclear Information System (INIS)

Welch, D.R.

1993-01-01

The author has simulated the proton transport of the 6-kA, 1-MV GAMBLE II experiment using a modified version of the IPROP particle-in-cell code. IPROP now uses a hybrid model in which plasma electrons are divided into high-energy macro particle and thermal-fluid components. This model includes open-quotes knock-onclose quotes bound-electron collision and runaway sources for high-energy electrons. Using IPROP, the authors has calculated net currents in reasonable agreement with the experiment ranging from 5-11% of the total current in pressures from 0.25-4 torr helium. In the simulations, the pinch current sample by the 1.5-cm beam was 2-3 times larger than the net current at 4 cm radius. The attenuation of net current at larger radii was the result of a highly-conductive energetic component of plasma electrons surrounding the beam. Having benchmarked IPROP against experiment, the author has examined higher-current ion beams with respect to possible transport for inertial confinement fusion

Analysis of selected critical experiments using ENDF/B-IV and ENDF/B-V data

International Nuclear Information System (INIS)

Crump, M.W.; Durston, C.; Jonsson, A.; Singh, U.N.

1983-01-01

Selected critical experiments were analyzed using ENDF/B-V data and results compared with measured parameters and with values obtained using ENDF/B-IV. The TRX-1 and -2 U-metal criticals were reanalyzed using ENDF/B-V with consistent multilevel processing of U-238 resonance data and increased spatial detail in the resonance slowing down calculations. The improved resonance treatment was applied in TRX cell calculations performed with the DIT code, and resulted in reduced predictions of U-238 capture by more than two percent relative to previous calculations. The results of the TRX analyses using ENDF/B-V indicate calculated rho 28 values 2 to 3% higher than measurements, and are found in overall agreement with results reported by other laboratories. Full core calculations for the TRX criticals were performed with the ANISN code using cross sections obtained from DIT core-reflector lattice calculations. An evaluation of core versus cell calculations for these criticals indicates differences corresponding to about one half percent in predicted reactivity

Congenital bilateral neuroblastoma (stage IV-S): case report

International Nuclear Information System (INIS)

Lee, Jeong Hee; Lee, Hee Jung; Woo, Seong Ku; Lee, Sang Rak; Kim, Heung Sik

2002-01-01

Congenital neonatal neuroblastoma is not uncommon but bilateral adrenal neuroblastoma is rare, accounting for about ten percent of neuroblastomas in children. We report the US the MR findings of a stage IV-S congenital bilateral neuroblastoma occurring in a one-day-old neonate

Effect of angiotensin II on proliferation and differentiation of mouse induced pluripotent stem cells into mesodermal progenitor cells

Energy Technology Data Exchange (ETDEWEB)

Ishizuka, Toshiaki, E-mail: tishizu@ndmc.ac.jp [Department of Pharmacology, National Defense Medical College, Tokorozawa, Saitama 359-8513 (Japan); Goshima, Hazuki; Ozawa, Ayako; Watanabe, Yasuhiro [Department of Pharmacology, National Defense Medical College, Tokorozawa, Saitama 359-8513 (Japan)

2012-03-30

Highlights: Black-Right-Pointing-Pointer Treatment with angiotensin II enhanced LIF-induced DNA synthesis of mouse iPS cells. Black-Right-Pointing-Pointer Angiotensin II may enhance the DNA synthesis via induction of superoxide. Black-Right-Pointing-Pointer Treatment with angiotensin II significantly increased JAK/STAT3 phosphorylation. Black-Right-Pointing-Pointer Angiotensin II enhanced differentiation into mesodermal progenitor cells. Black-Right-Pointing-Pointer Angiotensin II may enhance the differentiation via activation of p38 MAPK. -- Abstract: Previous studies suggest that angiotensin receptor stimulation may enhance not only proliferation but also differentiation of undifferentiated stem/progenitor cells. Therefore, in the present study, we determined the involvement of the angiotensin receptor in the proliferation and differentiation of mouse induced pluripotent stem (iPS) cells. Stimulation with angiotensin II (Ang II) significantly increased DNA synthesis in mouse iPS cells cultured in a medium with leukemia inhibitory factor (LIF). Pretreatment of the cells with either candesartan (a selective Ang II type 1 receptor [AT{sub 1}R] antagonist) or Tempol (a cell-permeable superoxide scavenger) significantly inhibited Ang II-induced DNA synthesis. Treatment with Ang II significantly increased JAK/STAT3 phosphorylation. Pretreatment with candesartan significantly inhibited Ang II- induced JAK/STAT3 phosphorylation. In contrast, induction of mouse iPS cell differentiation into Flk-1-positive mesodermal progenitor cells was performed in type IV collagen (Col IV)- coated dishes in a differentiation medium without LIF. When Col IV-exposed iPS cells were treated with Ang II for 5 days, the expression of Flk-1 was significantly increased compared with that in the cells treated with the vehicle alone. Pretreatment of the cells with both candesartan and SB203580 (a p38 MAPK inhibitor) significantly inhibited the Ang II- induced increase in Flk-1 expression

Effect of angiotensin II on proliferation and differentiation of mouse induced pluripotent stem cells into mesodermal progenitor cells

International Nuclear Information System (INIS)

Ishizuka, Toshiaki; Goshima, Hazuki; Ozawa, Ayako; Watanabe, Yasuhiro

2012-01-01

Highlights: ► Treatment with angiotensin II enhanced LIF-induced DNA synthesis of mouse iPS cells. ► Angiotensin II may enhance the DNA synthesis via induction of superoxide. ► Treatment with angiotensin II significantly increased JAK/STAT3 phosphorylation. ► Angiotensin II enhanced differentiation into mesodermal progenitor cells. ► Angiotensin II may enhance the differentiation via activation of p38 MAPK. -- Abstract: Previous studies suggest that angiotensin receptor stimulation may enhance not only proliferation but also differentiation of undifferentiated stem/progenitor cells. Therefore, in the present study, we determined the involvement of the angiotensin receptor in the proliferation and differentiation of mouse induced pluripotent stem (iPS) cells. Stimulation with angiotensin II (Ang II) significantly increased DNA synthesis in mouse iPS cells cultured in a medium with leukemia inhibitory factor (LIF). Pretreatment of the cells with either candesartan (a selective Ang II type 1 receptor [AT 1 R] antagonist) or Tempol (a cell-permeable superoxide scavenger) significantly inhibited Ang II-induced DNA synthesis. Treatment with Ang II significantly increased JAK/STAT3 phosphorylation. Pretreatment with candesartan significantly inhibited Ang II- induced JAK/STAT3 phosphorylation. In contrast, induction of mouse iPS cell differentiation into Flk-1-positive mesodermal progenitor cells was performed in type IV collagen (Col IV)- coated dishes in a differentiation medium without LIF. When Col IV-exposed iPS cells were treated with Ang II for 5 days, the expression of Flk-1 was significantly increased compared with that in the cells treated with the vehicle alone. Pretreatment of the cells with both candesartan and SB203580 (a p38 MAPK inhibitor) significantly inhibited the Ang II- induced increase in Flk-1 expression. Treatment with Ang II enhanced the phosphorylation of p38 MAPK in Col IV- exposed iPS cells. These results suggest that the stimulation

A portable data acquisition system on J.I.P.P. T-II ICRF experiment

International Nuclear Information System (INIS)

Hidekuma, S.

1982-03-01

This system has been developed for the data acquisition in the J.I.P.P. T-II ICRF experiment. It is composed of the LSI-11/2(56KB), a dual floppy disk drive, CAMAC modules, a graphic display and an interface module to the HITAC 10-II system. The operating system is RT-11. This system has functions of the data acquisition through A-D converters (max.32ch), the transfer of the data to the HITAC 10-II system and the preservation of them in its floppy disk. Furthermore, a user can easily develop his application programs with this system. The operating procedures of this system are described. (author)

Water/sand flooded and immersed critical experiment and analysis performed in support of the TOPAZ-II Safety Program

International Nuclear Information System (INIS)

Glushkov, E.S.; Ponomarev-Stepnoi, N.N.; Bubelev, V.G.; Garin, V.P.; Gomin, E.A.; Kompanietz, G.V.; Krutoy, A.M.; Lobynstev, V.A.; Maiorov, L.V.; Polyakov, D.N.

1994-01-01

Presented is a brief description of the Narciss-M2 critical assemblies, which simulate accidental water/wet-sand immersion of the TOPAZ-II reactor as well as water-flooding of core cavities. Experimental results obtained from these critical assemblies, including experiments with several fuel elements removed from the core, are shown. These configurations with several extracted fuel elements simulate a proposed fuel-out anticriticality-device modification to the TOPAZ-II reactor. Preliminary computational analysis of these experiments using the Monte Carlo neutron-transport method is outlined. Nuclear criticality safety of the TOPAZ-II reactor with an incorporated anticriticality unit is demonstrated

Surrogacy: the experiences of surrogate mothers.

Science.gov (United States)

Jadva, Vasanti; Murray, Clare; Lycett, Emma; MacCallum, Fiona; Golombok, Susan

2003-10-01

This study examined the motivations, experiences and psychological consequences of surrogacy for surrogate mothers. Thirty-four women who had given birth to a surrogate child approximately 1 year previously were interviewed by trained researchers, and the data rated using standardized coding criteria. Information was obtained on: (i) reasons for the woman's decision to become a surrogate mother; (ii) her retrospective view of the relationship with the commissioning couple before the pregnancy, during the pregnancy, and after the birth; (iii) her experiences during and after relinquishing the child; and (iv) how others reacted to her decision to become a surrogate mother. It was found that surrogate mothers do not generally experience major problems in their relationship with the commissioning couple, in handing over the baby, or from the reactions of those around them. The emotional problems experienced by some surrogate mothers in the weeks following the birth appeared to lessen over time. Surrogate mothers do not appear to experience psychological problems as a result of the surrogacy arrangement.

The MUSCLES Treasury Survey. IV. Scaling Relations for Ultraviolet, Ca ii K, and Energetic Particle Fluxes from M Dwarfs

Energy Technology Data Exchange (ETDEWEB)

Youngblood, Allison; France, Kevin; Loyd, R. O. Parke; Mason, James P. [Laboratory for Atmospheric and Space Physics, University of Colorado, 600 UCB, Boulder, CO 80309 (United States); Brown, Alexander [Center for Astrophysics and Space Astronomy, University of Colorado, 389 UCB, Boulder, CO 80309 (United States); Schneider, P. Christian [European Space Research and Technology Centre (ESA/ESTEC), Keplerlaan 1, 2201 AZ Noordwijk (Netherlands); Tilley, Matt A. [Department of Earth and Space Sciences, University of Washington, Box 351310, Seattle, WA 98195 (United States); Berta-Thompson, Zachory K.; Kowalski, Adam [Department of Astrophysical and Planetary Sciences, University of Colorado, 2000 Colorado Ave., Boulder, CO 80305 (United States); Buccino, Andrea; Mauas, Pablo J. D. [Dpto. de Física, Facultad de Ciencias Exactas y Naturales (FCEN), Universidad de Buenos Aires (UBA), Buenos Aires (Argentina); Froning, Cynthia S. [Department of Astronomy/McDonald Observatory, C1400, University of Texas at Austin, Austin, TX 78712 (United States); Hawley, Suzanne L. [Astronomy Department, Box 351580, University of Washington, Seattle, WA 98195 (United States); Linsky, Jeffrey [JILA, University of Colorado and NIST, 440 UCB, Boulder, CO 80309 (United States); Redfield, Seth [Astronomy Department and Van Vleck Observatory, Wesleyan University, Middletown, CT 06459 (United States); Miguel, Yamila [Observatoire de la Cote d’Azur, Boulevard de l’Observatoire, CS 34229 F-06304 NICE Cedex 4 (France); Newton, Elisabeth R. [Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02138 (United States); Rugheimer, Sarah, E-mail: allison.youngblood@colorado.edu [School of Earth and Environmental Sciences, University of St. Andrews, Irvine Building, North Street, St. Andrews, KY16 9AL (United Kingdom); and others

2017-07-01

Characterizing the UV spectral energy distribution (SED) of an exoplanet host star is critically important for assessing its planet’s potential habitability, particularly for M dwarfs, as they are prime targets for current and near-term exoplanet characterization efforts and atmospheric models predict that their UV radiation can produce photochemistry on habitable zone planets different from that on Earth. To derive ground-based proxies for UV emission for use when Hubble Space Telescope ( HST ) observations are unavailable, we have assembled a sample of 15 early to mid-M dwarfs observed by HST and compared their nonsimultaneous UV and optical spectra. We find that the equivalent width of the chromospheric Ca ii K line at 3933 Å, when corrected for spectral type, can be used to estimate the stellar surface flux in ultraviolet emission lines, including H i Ly α . In addition, we address another potential driver of habitability: energetic particle fluxes associated with flares. We present a new technique for estimating soft X-ray and >10 MeV proton flux during far-UV emission line flares (Si iv and He ii) by assuming solar-like energy partitions. We analyze several flares from the M4 dwarf GJ 876 observed with HST and Chandra as part of the MUSCLES Treasury Survey and find that habitable zone planets orbiting GJ 876 are impacted by large Carrington-like flares with peak soft X-ray fluxes ≥10{sup −3} W m{sup −2} and possible proton fluxes ∼10{sup 2}–10{sup 3} pfu, approximately four orders of magnitude more frequently than modern-day Earth.

Gene expression profiles in stages II and III colon cancers

DEFF Research Database (Denmark)

Thorsteinsson, Morten; Kirkeby, Lene T; Hansen, Raino

2012-01-01

PURPOSE: A 128-gene signature has been proposed to predict outcome in patients with stages II and III colorectal cancers. In the present study, we aimed to reproduce and validate the 128-gene signature in external and independent material. METHODS: Gene expression data from the original material...... were retrieved from the Gene Expression Omnibus (GEO) (n¿=¿111) in addition to a Danish data set (n¿=¿37). All patients had stages II and III colon cancers. A Prediction Analysis of Microarray classifier, based on the 128-gene signature and the original training set of stage I (n¿=¿65) and stage IV (n...... correctly predicted as stage IV-like, and the remaining patients were predicted as stage I-like and unclassifiable, respectively. Stage II patients could not be stratified. CONCLUSIONS: The 128-gene signature showed reproducibility in stage III colon cancer, but could not predict recurrence in stage II...

Fluxes at experiment facilities in HEU and LEU designs for the FRM-II

International Nuclear Information System (INIS)

Hanan, N. A.

1998-01-01

An Alternative LEU Design for the FRM-II proposed by the RERTR Program at Argonne National Laboratory (ANL) has a compact core consisting of a single fuel element that uses LEU silicide fuel with a uranium density of 4.5 g/cm 3 and has a power level of 32 MW. Both the HEU design by the Technical University of Munich (TUM) and the alternative LEU design by ANL have the same fuel lifetime(50 days) and the same neutron flux performance (8 x 10 14 n/cm 2 -s in the reflector). LEU silicide fuel with 4.5 g/cm 3 has been thoroughly tested and is fully-qualified, licensable, and available now for use in a high flux reactor such as the FRM-II. Several issues that were raised by TUM have been addressed in Refs. 1-3. The conclusions of these analyses are summarized below. This paper addresses four additional issues that have been raised in several forums, including Ref 4: heat generation in the cold neutron source (CNS), the gamma and fast neutron fluxes which are components of the reactor noise in neutron scattering experiments in the experiment hall of the reactor, a fuel cycle length difference, and the reactivity worth of the beam tubes and other experiment facilities. The results show that: (a) for the same thermal neutron flux, the neutron and gamma heating in the CNS is smaller in the LEU design than in the HEU design, and cold neutron fluxes as good or better than those of the HEU design can be obtained with the LEU design; (b) the gamma and fast neutron components of the reactor noise in the experiment hall are about the same in both designs; (c) the fuel cycle length is 50 days for both designs; and (d) the absolute value of the reactivity worth of the beam tubes and other experiment facilities is smaller in the LEU design, allowing its fuel cycle length to be increased to 53 or 54 days. Based on the excellent results for the Alternative LEU Design that were obtained in all analyses, the RERTR Program reiterates its conclusion that there are no major technical

Comparative analysis of Carnaval II Library

International Nuclear Information System (INIS)

Santos Bastos, W. dos

1981-01-01

The Carnaval II cross sections library from the french fast reactor calculation system is evaluated in two ways: 1 0 ) a comparative analysis of the calculations system for fast reactors at IEN (Instituto de Engenharia Nuclear) using a 'benchmark' model is done; 2 0 ) a comparative analysis in relation to the french system itself is also done, using calculations realized with two versions of the french library: the SETR-II and the CARNAVAL IV, the first one being anterior and the second one posterior to the Carnaval II version, the one used by IEN. (Author) [pt

Ion flotation of rhodium(III) and palladium(II) with anionic surfactants.

Science.gov (United States)

He, X C

1991-03-01

The ion flotation of rhodium(III) and palladium(II) with some anionic surfactants has been investigated. Two flotation procedures are proposed for the separation of some platinum metals, based on differences in the kinetic properties of the chloro-complexes of rhodium(III), palladium(II) and platinum(IV). The first involves the selective flotation of Rh(H(2)O)(3+)(6) from PdCl(2-)(4) and PtCl(2-)(6) in dilute hydrochloric acid with sodium dodecylbenzenesulfonate (SDBS). After precipitation of the hydroxide and redissolution in dilute acid, the Rh(III) is converted into Rh(H(2)O)(3+)(6), Pd(II) and Pt(IV) remaining as PdCl(2-)(4) and PtCl(2-)(6) respectively, and separation is achieved by floating the Rh(H(2)O)(3+)(6) with SDBS. The second is for separation of Pd(II). Prior to flotation, the solution of PdCl(2-)(4) and PtCl(2-)(6) is heated with ammonium acetate to convert PdCl(2-)(4) into Pd(NH(3))(2+)(4). The chloro-complex of Pt(IV) is unaffected. The complex cation, Pd(NH(3))(2+)(4), is then selectively floated with SDBS. The procedures are fast, simple and do not require expensive reagents and apparatus.

Type II solar radio bursts, interplanetary shocks, and energetic particle events

International Nuclear Information System (INIS)

Cane, H.V.; Stone, R.G.

1984-01-01

Using the ISEE 3 radio astronomy experiment data we have identified 37 interplanetary type II bursts in the period 1978 September to 1981 December. We lists these events and the associated phenomena. The events are preceded by intense, soft X-ray events with long decay times and type II or type IV bursts, or both, at meter wavelengths. The meter wavelength type II bursts are usually intense and exhibit herringbone structure. The extension of the herringbone structure into the kilometer wavelength range appears as a fast drift radio feature which we refer to as a shock associated radio event. The shock associated event is an important diagnostic for the presence of a strong shock and particle acceleration. The majority of the interplanetary type II bursts are associated with energetic particle events. Our results support other studies which indicate that energetic soalr particles detected at 1 A.U. are generatd by shock acceleration. From a preliminary analysis of the available data there appears to be a high correlation with white light coronal transients. The transients are fast: i.e., velocities greater than 500 km s -1

IRF-4-mediated CIITA transcription is blocked by KSHV encoded LANA to inhibit MHC II presentation.

Directory of Open Access Journals (Sweden)

Qiliang Cai

2013-10-01

Full Text Available Peptides presentation to T cells by MHC class II molecules is of importance in initiation of immune response to a pathogen. The level of MHC II expression directly influences T lymphocyte activation and is often targeted by various viruses. Kaposi's sarcoma-associated herpesvirus (KSHV encoded LANA is known to evade MHC class I peptide processing, however, the effect of LANA on MHC class II remains unclear. Here, we report that LANA down-regulates MHC II expression and presentation by inhibiting the transcription of MHC II transactivator (CIITA promoter pIII and pIV in a dose-dependent manner. Strikingly, although LANA knockdown efficiently disrupts the inhibition of CIITA transcripts from its pIII and pIV promoter region, the expression of HLA-DQβ but no other MHC II molecules was significantly restored. Moreover, we revealed that the presentation of HLA-DQβ enhanced by LANA knockdown did not help LANA-specific CD4+ T cell recognition of PEL cells, and the inhibition of CIITA by LANA is independent of IL-4 or IFN-γ signaling but dependent on the direct interaction of LANA with IRF-4 (an activator of both the pIII and pIV CIITA promoters. This interaction dramatically blocked the DNA-binding ability of IRF-4 on both pIII and pIV promoters. Thus, our data implies that LANA can evade MHC II presentation and suppress CIITA transcription to provide a unique strategy of KSHV escape from immune surveillance by cytotoxic T cells.

NeptuniumV Retention by Siderite under Anoxic Conditions: Precipitation of NpO2-Like Nanoparticles and of NpIV Pentacarbonate.

Science.gov (United States)

Scheinost, Andreas C; Steudtner, Robin; Hübner, René; Weiss, Stephan; Bok, Frank

2016-10-04

The Np V retention by siderite, an Fe II carbonate mineral with relevance for the near-field of high-level radioactive waste repositories, was investigated under anoxic conditions. Batch sorption experiments show that siderite has a high affinity for aqueous Np V O 2 + across pH 7 to 13 as expressed by solid-water distribution coefficients, log R d, > 5, similar to the log R d determined for the (solely) tetravalent actinide Th on calcite, suggesting reduction of Np V to Np IV by siderite. Np L 3 -edge X-ray absorption near edge (XANES) spectroscopy conducted in a pH range typical for siderite-containing host rocks (7-8), confirmed the tetravalent Np oxidation state. Extended X-ray absorption fine-structure (EXAFS) spectroscopy revealed a local structure in line with NpO 2 -like nanoparticles with diameter nanoparticles (∼10 -9 M), along with their negligible surface charge at neutral pH conditions which favors particle aggregation, suggest an efficient retention of Np in the near-field of radioactive waste repositories. When Np V was added to ferrous carbonate solution, the subsequent precipitation of siderite did not lead to a structural incorporation of Np IV by siderite, but caused precipitation of a Np IV pentacarbonate phase.

Streaming-plasma measurements in the Baseball II-T mirror experiment

International Nuclear Information System (INIS)

Damm, C.C.; Foote, J.H.; Futch, A.H.; Goodman, R.K.; Hornady, R.S.; Osher, J.E.; Porter, G.D.

1977-01-01

The warm plasma from a deuterium-loaded titanium washer gun, streaming along magnetic-field lines through the steady-state magnetic well of Baseball II, has been examined for its suitability in this experimental situation as a target plasma for hot-ion buildup experiments and for microinstability control. The gun was positioned near the magnetic axis outside the mirror region. Measurements were made with gridded, end-loss detectors placed outside the opposite mirror, a microwave interferometer, a beam-attenuation detector, and other diagnostics

Treatment of melasma with low fluence, large spot size, 1064-nm Q-switched neodymium-doped yttrium aluminum garnet (Nd:YAG) laser for the treatment of melasma in Fitzpatrick skin types II-IV.

Science.gov (United States)

Brown, Alia S; Hussain, Mussarat; Goldberg, David J

2011-12-01

Melasma is a common condition affecting over six million American women. Treatment of dermal or combined melasma is difficult and does not respond well to conventional topical therapies. Various light sources have been used recently in the treatment of melasma including fractionated ablative and non-ablative lasers as well as intense pulse light. We report the use of low fluence, large spot size Q-switched, Nd:Yag laser for the treatment of melasma in skin types II-IV.

Incidence and specificity of antibodies to types I, II, III, IV, and V collagen in rheumatoid arthritis and other rheumatic diseases as measured by 125I-radioimmunoassay

International Nuclear Information System (INIS)

Stuart, J.M.; Huffstutter, E.H.; Townes, A.S.; Kang, A.H.

1983-01-01

Antibodies to human native and denatured types I, II, III, IV, and V collagens were measured using 125I-radioimmunoassay. Mean levels of binding by sera from 30 rheumatoid arthritis patients were significantly higher than those from 20 normal subjects against all of the collagens tested. The relative antibody concentration was higher in synovial fluid than in simultaneously obtained serum. Many patients with gout or various other rheumatic diseases also had detectable anticollagen antibodies. With a few notable exceptions, the majority of the reactivity detected in all patient groups was directed against covalent structural determinants present on all of the denatured collagens, suggesting a secondary reaction to tissue injury

Experiences in commissioning and in the first operating cycle of GKN-II

International Nuclear Information System (INIS)

Grauf, E.; Zaiss, W.; Tschannerl, J.

1990-01-01

In 1989, after only four and a half years of construction, the second unit of the Neckar Joint Nuclear Power Station (GKN-II) was commissioned as the third convoy type nuclear power plant. Its gross power of 1314 MWe makes the pressurized water reactor of GKN-II a unit in the highest power category so far of Siemens/KWU. Delivery to the operators ahead of schedule and observance of the budget are conclusive proof of the advantages of the convoy principle. In addition, GKN-II was able to benefit from the experience accumulated in the construction and commissioning of the two earlier convoy plants. This was reflected in the speedy completion, without major disturbances, of the warranty tests and the trial period of operation. It also has an impact on power operation, the first cycle of which showed the plant to have an availability of 100% throughout and is considered to be a full success by the operators. A special feature of GKN-II is the hybrid cooling tower ensuring that no heated cooling water is returned from the plant into the Neckar river. (orig.) [de

PENERAPAN TEAMS GAMES TOURNAMENT UNTUK MENINGKATKAN HASIL BELAJAR IPS KELAS IV SDN BLABAK 1 KANDAT KEDIRI

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Moh. Adnan Khohar

2016-09-01

Full Text Available The purpose of this research is to improve the social studies grade IV SDN Blabak 1 Kandat Kediri through the implementation Teams Games Tournament (TGT. This type of research is the Classroom Action Research (PTK. This research is located at Jalan Kediri, Blitar, Kediri Kandat. The subjects in this study were students of class IV SDN Blabak 1 Kandat Kediri totaling 29 children, with the number of students 12 and older schoolgirls 17 children. This study was conducted in 2 cycles and each cycle consisting of 3 meetings. The instrument used was observation completely learning activities by students and teachers. Observation assessment of affective and psychomotor, and cognitive abilities test. Assessment of cognitive cycle students achieve mastery gained 72.23% and cycle II reached 82.75% in psychomotor in the first cycle and reach 69.4% in the second cycle reaches 87.92% for affective students in the first cycle and the second to reach complete 67.23% and 74.13%. The conclusion of this study reveal that through the implementation of TGT in the learning process at school are able to improve learning outcomes IPS fourth grade students at SDN 1 Blabak Kandat Kediri year 2015/2016 on the development of material production technology, communications, and transportation. Tujuan penelitian ini adalah untuk meningkatkan hasil belajar IPS siswa kelas IV SDN Blabak 1 Kandat Kediri melalui penerapan Teams Games Tournament (TGT. Jenis penelitian yang digunakan adalah Penelitian Tindakan Kelas (PTK. Lokasi penelitian adalah di Jalan Kediri-Blitar Kandat Kediri. Kemudian subjek dalam penelitian ini adalah siswa-siswa kelas IV SDN Blabak 1 Kandat Kediri yang berjumlah 29 anak, dengan jumlah siswa 12 anak dan siswi 17 anak. Penelitian ini dilaksanakan dalam 2 siklus dan setiap siklus terdiri atas 3 pertemuan. Instrumen yang digunakan adalah lembar observasi keterlaksanaan aktivitas pembelajaran oleh siswa dan guru. Lembar observasi penilaian afektif dan

What is hypomania? Tetrachoric factor analysis and kernel estimation of DSM-IV hypomanic symptoms.

Science.gov (United States)

Benazzi, Franco

2009-11-01

The DSM-IV definition of hypomania, which relies on clinical consensus and historical tradition, includes several "nonspecific" symptoms. The aim of this study was to identify the core symptoms of DSM-IV hypomania. In an outpatient private practice, 266 bipolar II disorder (BP-II) and 138 major depressive disorder (MDD) remitted patients were interviewed by a bipolar-trained psychiatrist, for different study goals. Patients were questioned, using the Structured Clinical Interview for DSM-IV, about the most common symptoms and duration of recent threshold and subthreshold hypomanic episodes. Data were recorded between 2002 and 2006. Four different samples, assessed with the same methodology, were pooled for the present analyses. Tetrachoric factor analysis was used to identify core hypomanic symptoms. Distribution of symptoms by kernel estimation was inspected for bimodality. Validity of core hypomania was tested by receiver operating characteristic (ROC) analysis. The distribution of subthreshold and threshold hypomanic episodes did not show bimodality. Tetrachoric factor analysis found 2 uncorrelated factors: factor 1 included the "classic" symptoms elevated mood, inflated self-esteem, decreased need for sleep, talkativeness, and increase in goal-directed activity (overactivity); factor 2 included the "nonspecific" symptoms irritable mood, racing/crowded thoughts, and distractibility. Factor 1 discriminatory accuracy for distinguishing BP-II versus MDD was high (ROC area = 0.94). The distribution of the 5-symptom episodes of factor 1 showed clear-cut bimodality. Similar results were found for episodes limited to 3 behavioral symptoms of factor 1 (decreased need for sleep, talkativeness, and overactivity) and 4 behavioral symptoms of factor 1 (adding elevated mood), with high discriminatory accuracy. A core, categorical DSM-IV hypomania was found that included 3 to 5 symptoms, ie, behavioral symptoms and elevated mood. Behavioral symptoms (overactivity domain

10.-14. II on Puhta Rõõmu alaliiduna tuntud...

Index Scriptorium Estoniae

2004-01-01

Lõkerdus- ja tegevuskunstikollektiiv Naeruorgesster ehk Laffing ahkestra - dirigent Erki Kannus, lõkerdajad Ivika Kivi, Piret Räni, Merle Kannus, Maris Mändel, Marge Monko, Aino Sepp, Annika Kaljurand, Anya Ronacher - esines 11. II Stockholmis Moderna Museeti taasavamispidustuste raames, 12. II osaleti tegevuskunstiprogrammis "Source Live 2004". Aprillis oodatakse kollektiivi Varssavisse Zacheta galerii näitusele "Poisid ja tüdrukud" (16. II-4. IV), kus esitatakse Piret Räni ja Anu Vahtra videot "Punk.Fem.Collection"

Preliminary optimization experiments of coupled liquid hydrogen moderator for KENS-II

International Nuclear Information System (INIS)

Watanabe, N.; Kiyanagi, Y.; Inoue, K.; Furusaka, M.; Ikeda, S.; Arai, M.; Iwasa, H.

1989-01-01

As a preliminary optimization experiment on the cold-neutron source for KENS-II, energy and time distributions of cold neutrons emanating from coupled liquid-hydrogen moderators with and without a premoderator in a graphite reflector were measured and compared with those from a decoupled liquid-hydrogen moderator. The results showed that the energy spectra from the coupled liquid-hydrogen moderators are almost the same as those from a decoupled one. Relative gain of the former to the latter is fairly high, more than 5, and further increases with increasing wavelength. The broadening of the neutron pulse width in coupled moderators at the cold-neutron region is not so significant and only 1.5 times compared to the solid methane moderator presently operated at KENS-II. 2 refs., 12 figs., 1 tab

Healthcare providers' experiences screening for intimate partner violence among migrant and seasonal farmworking women: A phenomenological study.

Science.gov (United States)

Wilson, Jonathan B; Rappleyea, Damon L; Hodgson, Jennifer L; Brimhall, Andrew S; Hall, Tana L; Thompson, Alyssa P

2016-12-01

Migrant and seasonal farmworking (MSFW) women patients experience substantially more intimate partner violence (IPV) than the general population, but few health-care providers screen patients for IPV. While researchers have examined screening practices in health-care settings, none have exclusively focused on MSFW women. The aim of this phenomenological study was to explore the experiences of health-care providers who have screened for and/or addressed IPV with MSFW women patients. Researchers utilized descriptive phenomenology to capture the lived experiences of these health-care providers. Data were analysed using Colaizzi's seven-stage framework. Interviews were conducted with nine female participants - all of whom: (i) were clinically active health-care providers within the MSFW community, (ii) were bilingual in English and Spanish or had access to a translator, (iii) had treated MSFW patients who had experienced IPV and (iv) were at least 18 years of age. Participants' experiences were reflected in four emergent themes: (i) provider-centered factors, (ii) patient-centered factors, (iii) clinic-centered factors and (iv) community-centered factors. Participants described barriers to establish routine IPV assessment, decrease patient ambivalence and increase on-site support and community resources. This study aimed to generate a greater understanding of the experiences of health-care providers with screening for and addressing IPV with MSFW patients. Implications and recommendations for research, clinical practice and policy are provided. © 2015 The Authors. Health Expectations Published by John Wiley & Sons Ltd.

Advanced Computational Materials Science: Application to Fusion and Generation IV Fission Reactors (Workshop Report)

Energy Technology Data Exchange (ETDEWEB)

Stoller, RE

2004-07-15

presented during the workshop apply equally to both types of nuclear energy systems. The primary factor that differentiates the materials development path for the two systems is that nearly prototypical irradiation environments for Gen-IV materials can be found or built in existing fission reactors. This is not the case for fusion. The only fusion-relevant, 14 MeV neutron sources ever built (such as the rotating target neutron sources, RTNS-I and -II at LLNL) were relatively low-power accelerator based systems. The RTNS-II ''high'' flux irradiation volume was quite small, less than 1 cm{sup 3}, and only low doses could be achieved. The maximum dose data obtained was much less than 0.1 dpa. Thus, RTNS-II, which last operated in 1986, provided only a limited opportunity for fundamental investigations of the effects of 14 MeV neutrons characteristic of DT fusion.

Complexation of the actinides (III, IV and V) with organic acids

International Nuclear Information System (INIS)

Leguay, S.

2012-01-01

A thorough knowledge of the chemical properties of actinides is now required in a wide variety of fields: extraction processes involved in spent fuel reprocessing, groundwater in the vicinity of radioactive waste packages, environmental and biological media in the case of accidental release of radionuclides. In this context, the present work has been focused on the complexation of Am(III), Cm(III), Cf(III), Pu(IV) and Pa(V) with organic ligands: DTPA, NTA and citric acid. The complexation of pentavalent protactinium with citric and nitrilotriacetic acids was studied using liquid-liquid extraction with the element at tracer scale (C Pa ≤ 10 -10 M). The order and the mean charge of each complex were determined from the analysis of the systematic variations of the distribution coefficient of Pa(V) as function of ligand and proton concentration. Then, the apparent formation constants related of the so-identified complexes were calculated. The complexation of trivalent actinides with DTPA was studied by fluorescence spectroscopy (TRLFS) and capillary electrophoresis (CE-ICP-MS). The coexistence of the mono-protonated and non-protonated complexes (AnHDTPA - and AnDTPA 2- ) in acidic media (1.5 ≤ pH ≤ 3.5) was shown unambiguously. Literature data have been reinterpreted by taking into account both complexes and a consistent set of formation constants of An(III)-DTPA has been obtained. The experimental study was completed by theoretical calculations (DFT) on Cm-DTPA system. The coordination geometry of Cm in CmDTPA 2- and CmHDTPA - including water molecules in the first coordination sphere has been determined as well as interatomic distances. Finally, a study on the complexation of Pu(IV) with DTPA was initiated in order to more closely mimic physiological conditions. A three-step approach was proposed to avoid plutonium hydrolysis: i/ complexation of Pu(IV) with (NTA) in order to protect Pu(IV) from hydrolysis (at low pH) ii/ increase of pH toward neutral conditions

Water/sand flooded and immersed critical experiment and analysis performed in support of the TOPAZ-II safety program

International Nuclear Information System (INIS)

Glushkov, E.S.; Ponomarev-Stepnoi, N.N.; Bubelev, V.G.; Garin, V.P.; Gomin, E.A.; Kompanietz, G.V.; Krutov, A.M.; Lobynstev, V.A.; Maiorov, L.V.; Polyakov, D.N.; Chunyaev, E.I.; Marshall, A.C.; Sapir, J.L.; Pelowitz, D.B.

1995-01-01

Presented is a brief description of the Narciss-M2 critical assemblies, which simulate accidental water/wet-sand immersion of the TOPAZ-II reactor as well as water-flooding of core cavities. Experimental results obtained from these critical assemblies, including experiments with several fuel elements removed from the core, are shown. These configurations with several extracted fuel elements simulate a proposed fuel-out anticriticality-device modification to the TOPAZ-II reactor. Preliminary computational analysis of these experiments using the Monte Carlo neutron-transport method is outlined. Nuclear criticality safety of the TOPAZ-II reactor with an incorporated anticriticality unit is demonstrated. copyright 1995 American Institute of Physics

Advantages and Disadvantages of the Amplatzer Vascular Plug IV in Visceral Embolization: Report of 50 Placements

International Nuclear Information System (INIS)

Pech, Maciej; Mohnike, Konrad; Wieners, Gero; Seidensticker, Ricarda; Seidensticker, Max; Zapasnik, Adam; Ricke, Jens; Dudeck, Oliver

2011-01-01

Purpose: We describe our initial clinical experience in artificial embolization with the Amplatzer Vascular Plug IV (VP IV), a further development of the Vascular Plug family already in routine use. Methods: Results from 50 embolization procedures conducted with the VP IV in 44 patients are summarized. Results: All 50 embolizations were successful, although two required the technique to be modified because of problems with jamming of the screw thread and thus with disconnection of the plug. This was associated with large branching angles. Conclusions: With experience, the VP IV can be used safely and effectively, and it expands the spectrum of possible embolizations in interventional radiology. Its greatest disadvantage is its relatively poor positional controllability.

Chemiluminescent determination of vanadium(IV) using a cinchomeronic hydrazide-H2O2 system and flow injection analysis

International Nuclear Information System (INIS)

Pradana Perez, J.A.; Alegria, J.S. Durand; Hernando, P. Fernandez; Sierra, A. Narros

2005-01-01

This paper proposes a new chemiluminescent flow injection analysis (FIA) method for the determination of vanadium(IV) ions in aqueous media. The method is based on the chemiluminescent reaction that occurs between cinchomeronic hydrazide (CH) and hydrogen peroxide in a strongly alkaline medium, in which vanadium(IV) acts as a catalyst. The chemical and physical variables involved in the flow injection system are optimised using a modified simplex method. Vanadium ions can be detected in the 0.08 and 1.00 μg mL -1 range; the detection limit for a signal-to-noise ratio of 3 is 0.08 μg mL -1 . Great variations in the quantum yield were observed when cobalt(II), chromium(III), copper(II) and/or nickel(II) were present in the reaction medium. The proposed method is selective and simple, and can be successfully used to analyse water samples without the need for separation or preconcentration processes

Measurement of population inversion for FUV transitions in Kr-like Y IV in a high-current reflex discharge

International Nuclear Information System (INIS)

Fournier, K.B.; Shlyaptsev, V.N.; Goldstein, W.H.; Stutman, D.; Soukhanovskii, V.; Finkenthal, M.; May, M.J.; Vero, R.

2000-01-01

Kr-like ions are good candidates for FUV lasing since they can be produced in plasmas quite easily. We present results from a spectroscopic investigation of Y IV emission from a high current density, cold cathode reflex discharge. The Y II to Y V emission is recorded in the 200-3000 A range using photometrically calibrated spectrometers, while the emission of trace aluminum ions serves for plasma diagnostics. The intensities of the Y IV 4d-5p and 5s7-5p transitions strongly increase relative to lines from Y II and Y III with increasing plasma current. The spectra studied here are obtained at a current density of 1.75 A/cm 2 . Experimental Y IV intensity ratios spanning several excited configurations are compared with collisional radiative predictions of the HULLAC atomic physics package. Good agreement is found for the measured and predicted ratios of 4p 5 5p to 4p 5 5s level populations per statistical weight. Finally, the response of the Kr-like system to a fast, transient excitation pulse is examined using the RADEX code. Large transient gains are predicted for several 5s-5p transitions in Kr-like Y IV. (orig.)

Oxochloroalkoxide of the Cerium (IV and Titanium (IV as oxides precursor

Directory of Open Access Journals (Sweden)

Machado Luiz Carlos

2002-01-01

Full Text Available The Cerium (IV and Titanium (IV oxides mixture (CeO2-3TiO2 was prepared by thermal treatment of the oxochloroisopropoxide of Cerium (IV and Titanium (IV. The chemical route utilizing the Cerium (III chloride alcoholic complex and Titanium (IV isopropoxide is presented. The compound Ce5Ti15Cl16O30 (iOPr4(OH-Et15 was characterized by elemental analysis, FTIR and TG/DTG. The X-ray diffraction patterns of the oxides resulting from the thermal decomposition of the precursor at 1000 degreesC for 36 h indicated the formation of cubic cerianite (a = 5.417Å and tetragonal rutile (a = 4.592Å and (c = 2.962 Å, with apparent crystallite sizes around 38 and 55nm, respectively.

Phase II Upgrade of the GERDA Experiment for the Search of Neutrinoless Double Beta Decay

Science.gov (United States)

Majorovits, B.

Observation of neutrinoless double beta decay could answer the question regarding the Majorana or Dirac nature of neutrinos. The GERDA experiment utilizes HPGe detectors enriched with the isotope 76Ge to search for this process. Recently the GERDA collaboration has unblinded data of Phase I of the experiment. In order to further improve the sensitivity of the experiment, additionally to the coaxial detectors used, 30 BEGe detectors made from germanium enriched in 76Ge will be deployed in GERDA Phase II. BEGe detectors have superior PSD capability, thus the background can be further reduced. The liquid argon surrounding the detector array will be instrumented in order to reject background by detecting scintillation light induced in the liquid argon by radiation. After a short introduction the hardware preparations for GERDA Phase II as well as the processing and characterization of the 30 BEGe detectors are discussed.

Experiment on performance of upper head injection system with ROSA-II

International Nuclear Information System (INIS)

1978-05-01

Of the total 10 ROSA-II/UHI performance tests, 6 were reported previously. The rest are presented and discussion is made on the effects of heat generation in the core and UHI injection and repeatability of experiments. In addition, the following are described: (1) Pressure spikes observed in the upper head after sudden stoppage of UHI injection, and (2) discharge flow oscillation possibly due to UHI water injection into the upper plenum. (auth.)

Clinical utility of the Wechsler Memory Scale - Fourth Edition (WMS-IV) in patients with intractable temporal lobe epilepsy.

Science.gov (United States)

Bouman, Zita; Elhorst, Didi; Hendriks, Marc P H; Kessels, Roy P C; Aldenkamp, Albert P

2016-02-01

The Wechsler Memory Scale (WMS) is one of the most widely used test batteries to assess memory functions in patients with brain dysfunctions of different etiologies. This study examined the clinical validation of the Dutch Wechsler Memory Scale - Fourth Edition (WMS-IV-NL) in patients with temporal lobe epilepsy (TLE). The sample consisted of 75 patients with intractable TLE, who were eligible for epilepsy surgery, and 77 demographically matched healthy controls. All participants were examined with the WMS-IV-NL. Patients with TLE performed significantly worse than healthy controls on all WMS-IV-NL indices and subtests (p<.01), with the exception of the Visual Working Memory Index including its contributing subtests, as well as the subtests Logical Memory I, Verbal Paired Associates I, and Designs II. In addition, patients with mesiotemporal abnormalities performed significantly worse than patients with lateral temporal abnormalities on the subtests Logical Memory I and Designs II and all the indices (p<.05), with the exception of the Auditory Memory Index and Visual Working Memory Index. Patients with either a left or a right temporal focus performed equally on all WMS-IV-NL indices and subtests (F(15, 50)=.70, p=.78), as well as the Auditory-Visual discrepancy score (t(64)=-1.40, p=.17). The WMS-IV-NL is capable of detecting memory problems in patients with TLE, indicating that it is a sufficiently valid memory battery. Furthermore, the findings support previous research showing that the WMS-IV has limited value in identifying material-specific memory deficits in presurgical patients with TLE. Copyright © 2015 Elsevier Inc. All rights reserved.

APOGEE-2: The Second Phase of the Apache Point Observatory Galactic Evolution Experiment in SDSS-IV

Science.gov (United States)

Sobeck, Jennifer; Majewski, S.; Hearty, F.; Schiavon, R. P.; Holtzman, J. A.; Johnson, J.; Frinchaboy, P. M.; Skrutskie, M. F.; Munoz, R.; Pinsonneault, M. H.; Nidever, D. L.; Zasowski, G.; Garcia Perez, A.; Fabbian, D.; Meza Cofre, A.; Cunha, K. M.; Smith, V. V.; Chiappini, C.; Beers, T. C.; Steinmetz, M.; Anders, F.; Bizyaev, D.; Roman, A.; Fleming, S. W.; Crane, J. D.; SDSS-IV/APOGEE-2 Collaboration

2014-01-01

The second phase of the Apache Point Observatory Galactic Evolution Experiment (APOGEE-2), a part of the Sloan Digital Sky Survey IV (SDSS-IV), will commence operations in 2014. APOGEE-2 represents a significant expansion over APOGEE-1, not only in the size of the stellar sample, but also in the coverage of the sky through observations in both the Northern and Southern Hemispheres. Observations on the 2.5m Sloan Foundation Telescope of the Apache Point Observatory (APOGEE-2N) will continue immediately after the conclusion of APOGEE-1, to be followed by observations with the 2.5m du Pont Telescope of the Las Campanas Observatory (APOGEE-2S) within three years. Over the six-year lifetime of the project, high resolution (R˜22,500), high signal-to-noise (≥100) spectroscopic data in the H-band wavelength regime (1.51-1.69 μm) will be obtained for several hundred thousand stars, more than tripling the total APOGEE-1 sample. Accurate radial velocities and detailed chemical compositions will be generated for target stars in the main Galactic components (bulge, disk, and halo), open/globular clusters, and satellite dwarf galaxies. The spectroscopic follow-up program of Kepler targets with the APOGEE-2N instrument will be continued and expanded. APOGEE-2 will significantly extend and enhance the APOGEE-1 legacy of scientific contributions to understanding the origin and evolution of the elements, the assembly and formation history of galaxies like the Milky Way, and fundamental stellar astrophysics.

Comparison between steady-state and dynamic I-V measurements from a single-cell thermionic fuel element

International Nuclear Information System (INIS)

Wernsman, Bernard

1997-01-01

A comparison between steady-state and dynamic I-V measurements from a single-cell thermionic fuel element (TFE) is made. The single-cell TFE used in this study is the prototype for the 40 kW e space nuclear power system that is similar to the 6 kW e TOPAZ-II. The steady-state I-V measurements influence the emitter temperature due to electron cooling. Therefore, to eliminate the steady-state I-V measurement influence on the TFE and provide a better understanding of the behavior of the thermionic energy converter and TFE characteristics, dynamic I-V measurements are made. The dynamic I-V measurements are made at various input power levels, cesium pressures, collector temperatures, and steady-state current levels. From these measurements, it is shown that the dynamic I-V's do not change the TFE characteristics at a given operating point. Also, the evaluation of the collector work function from the dynamic I-V measurements shows that the collector optimization is not due to a minimum in the collector work function but due to an emission optimization. Since the dynamic I-V measurements do not influence the TFE characteristics, it is believed that these measurements can be done at a system level to understand the influence of TFE placement in the reactor as a function of the core thermal distribution

Profiling the Metabolism of Astragaloside IV by Ultra Performance Liquid Chromatography Coupled with Quadrupole/Time-of-Flight Mass Spectrometry

Directory of Open Access Journals (Sweden)

Xu-Dong Cheng

2014-11-01

Full Text Available Astragaloside IV is a compound isolated from the Traditional Chinese Medicine Astragalus membranaceus, that has been reported to have bioactivities against cardiovascular disease and kidney disease. There is limited information on the metabolism of astragaloside IV, which impedes comprehension of its biological actions and pharmacology. In the present study, an ultra-performance liquid chromatography coupled with quadrupole/time-of-flight mass spectrometry (UPLC-Q-TOF-MS/MS-based approach was developed to profile the metabolites of astragaloside IV in rat plasma, bile, urine and feces samples. Twenty-two major metabolites were detected. The major components found in plasma, bile, urine and feces included the parent chemical and phases I and II metabolites. The major metabolic reactions of astragaloside IV were hydrolysis, glucuronidation, sulfation and dehydrogenation. These results will help to improve understanding the metabolism and reveal the biotransformation profiling of astragaloside IV in vivo. The metabolic information obtained from our study will guide studies into the pharmacological activity and clinical safety of astragaloside IV.

Field Sampling Plan for the Operable Units 6-05 and 10-04 Remedial Action, Phase IV

Energy Technology Data Exchange (ETDEWEB)

R. Wells

2006-11-14

This Field Sampling Plan outlines the collection and analysis of samples in support of Phase IV of the Waste Area Group 10, Operable Units 6-05 and 10-04 remedial action. Phase IV addresses the remedial actions to areas with the potential for unexploded ordnance at the Idaho National Laboratory Site. These areas include portions of the Naval Proving Ground, the Arco High-Altitude Bombing Range, and the Twin Buttes Bombing Range. The remedial action consists of removal and disposal of ordnance by high-order detonation, followed by sampling to determine the extent, if any, of soil that might have been contaminated by the detonation activities associated with the disposal of ordnance during the Phase IV activities and explosives during the Phase II activities.

Plasma flow switch and foil implosion experiments on Pegasus II

International Nuclear Information System (INIS)

Cochrane, J.C.; Bartsch, R.R.; Benage, J.R.; Forman, P.R.; Gribble, R.F.; Ladish, J.S.; Oona, H.; Parker, J.V.; Scudder, D.W.; Shlachter, J.S.; Wysocki, F.J.

1993-01-01

Pegasus II is the upgraded version of Pegasus, a pulsed power machine used in the Los Alamos AGEX (Above Ground EXperiments) program. A goal of the program is to produce an intense (> 100 TW) source of soft x-rays from the thermalization of the kinetic energy of a 1 to 10 MJ plasma implosion. The radiation pulse should have a maximum duration of several 10's of nanoseconds and will be used in the study of fusion conditions and material properties. The radiating plasma source will be generated by the thermalization of the kinetic energy of an imploding cylindrical, thin, metallic foil. This paper addresses experiments done on a capacitor bank to develop a switch (plasma flow switch) to switch the bank current into the load at peak current. This allows efficient coupling of bank energy into foil kinetic energy

Procedures and instrumentation for sodium boiling experiments in EBR-II

International Nuclear Information System (INIS)

Crowe, R.D.

1976-01-01

The development of instrumentation capable of detecting localized coolant boiling in a liquid metal cooled breeder reactor (LMFBR) has a high priority in fast reactor safety. The detection must be rapid enough to allow corrective action to be taken before significant damage occurs to the core. To develop and test a method of boiling detection, it is desirable to produce boiling in a reactor and thereby introduce a condition in the reactor the original design concepts were chosen to preclude. The proposed boiling experiments are designed to safely produce boiling in the subassembly of a fast reactor and provide the information to develop boiling detection instrumentation without core damage or safety compromise. The experiment consists of the operation of two separate subassemblies, first, a gamma heated boiling subassembly which produces non-typical but highly conservative boiling and then a fission heated subassembly which simulates a prototypical boiling event. The two boiling subassemblies are designed to operate in the instrumentation subassembly test facility (INSAT) of Experiment Breeder Reactor II

Medicinal flowers. XXVII. New flavanone and chalcone glycosides, arenariumosides I, II, III, and IV, and tumor necrosis factor-alpha inhibitors from everlasting, flowers of Helichrysum arenarium.

Science.gov (United States)

Morikawa, Toshio; Wang, Li-Bo; Nakamura, Seikou; Ninomiya, Kiyofumi; Yokoyama, Eri; Matsuda, Hisashi; Muraoka, Osamu; Wu, Li-Jun; Yoshikawa, Masayuki

2009-04-01

The methanolic extract from the flowers of Helichrysum arenarium L. MOENCH was found to show inhibitory effect on tumor necrosis factor-alpha (TNF-alpha, 1 ng/ml)-induced cytotoxicity in L929 cells. From the methanolic extract, 50 constituents including four new flavanone and chalcone glycosides named arenariumosides I (1), II (2), III (3), and IV (4) were isolated. The stereostructures of 1-4 were elucidated on the basis of chemical and physicochemical evidence. Among the constituents, naringenin 7-O-beta-D-glucopyranoside (7), apigenin 7-O-beta-D-glucopyranoside (14), apigenin 7-O-gentiobioside (16), and apigenin 7,4'-di-O-beta-D-glucopyranoside (17) significantly inhibited TNF-alpha-induced cytotoxicity in L929 cells at 30 microM.

Enterotoxigenic Escherichia coli Adhesin-Toxoid Multiepitope Fusion Antigen CFA/I/II/IV-3xSTaN12S-mnLTG192G/L211A-Derived Antibodies Inhibit Adherence of Seven Adhesins, Neutralize Enterotoxicity of LT and STa Toxins, and Protect Piglets against Diarrhea.

Science.gov (United States)

Nandre, Rahul; Ruan, Xiaosai; Lu, Ti; Duan, Qiangde; Sack, David; Zhang, Weiping

2018-03-01

Enterotoxigenic Escherichia coli (ETEC) strains are a leading cause of children's diarrhea and travelers' diarrhea. Vaccines inducing antibodies to broadly inhibit bacterial adherence and to neutralize toxin enterotoxicity are expected to be effective against ETEC-associated diarrhea. 6×His-tagged adhesin-toxoid fusion proteins were shown to induce neutralizing antibodies to several adhesins and LT and STa toxins (X. Ruan, D. A. Sack, W. Zhang, PLoS One 10:e0121623, 2015, https://doi.org/10.1371/journal.pone.0121623). However, antibodies derived from His-tagged CFA/I/II/IV-2xSTa A14Q -dmLT or CFA/I/II/IV-2xSTa N12S -dmLT protein were less effective in neutralizing STa enterotoxicity and were not evaluated in vivo for efficacy against ETEC diarrhea. Additionally, His-tagged proteins are considered less desirable for human vaccines. In this study, we produced a tagless adhesin-toxoid MEFA (multiepitope fusion antigen) protein, enhanced anti-STa immunogenicity by including a third copy of STa toxoid STa N12S , and examined antigen immunogenicity in a murine model. Moreover, we immunized pregnant pigs with the tagless adhesin-toxoid MEFA protein and evaluated passive antibody protection against STa + or LT + ETEC infection in a pig challenge model. Results showed that tagless adhesin-toxoid MEFA CFA/I/II/IV-3xSTa N12S -mnLT R192G/L211A induced broad antiadhesin and antitoxin antibody responses in the intraperitoneally immunized mice and the intramuscularly immunized pigs. Mouse and pig serum antibodies significantly inhibited adherence of seven colonization factor antigen (CFA) adhesins (CFA/I and CS1 to CS6) and effectively neutralized both toxins. More importantly, suckling piglets born to the immunized mothers acquired antibodies and were protected against STa + ETEC and LT + ETEC diarrhea. These results indicated that tagless CFA/I/II/IV-3xSTa N12S -mnLT R192G/L211A induced broadly protective antiadhesin and antitoxin antibodies and demonstrate that this adhesin

Sandia Pulse Reactor-IV Project

International Nuclear Information System (INIS)

Reuscher, J.A.

1983-01-01

Sandia National Laboratories has developed, designed and operated fast burst reactors for over 20 years. These reactors have been used for a variety of radiation effects programs. During this period, programs have required larger irradiation volumes primarily to expose complex electronic systems to postulated threat environments. As experiment volumes increased, a new reactor was built so that these components could be tested. The Sandia Pulse Reactor-IV is a logical evolution of the two decades of fast burst reactor development at Sandia

Antisocial Personality Disorder Subscale (Chinese Version) of the Structured Clinical Interview for the DSM-IV Axis II disorders: validation study in Cantonese-speaking Hong Kong Chinese.

Science.gov (United States)

Tang, D Y Y; Liu, A C Y; Leung, M H T; Siu, B W M

2013-06-01

OBJECTIVE. Antisocial personality disorder (ASPD) is a risk factor for violence and is associated with poor treatment response when it is a co-morbid condition with substance abuse. It is an under-recognised clinical entity in the local Hong Kong setting, for which there are only a few available Chinese-language diagnostic instruments. None has been tested for its psychometric properties in the Cantonese-speaking population in Hong Kong. This study therefore aimed to assess the reliability and validity of the Chinese version of the ASPD subscale of the Structured Clinical Interview for the DSM-IV Axis II Disorders (SCID-II) in Hong Kong Chinese. METHODS. This assessment tool was modified according to dialectal differences between Mainland China and Hong Kong. Inpatients in Castle Peak Hospital, Hong Kong, who were designated for priority follow-up based on their assessed propensity for violence and who fulfilled the inclusion criteria for the study, were recruited. To assess the level of agreement, best-estimate diagnosis made by a multidisciplinary team was compared with diagnostic status determined by the SCID-II ASPD subscale. The internal consistency, sensitivity, and specificity of the subscale were also calculated. RESULTS. The internal consistency of the subscale was acceptable at 0.79, whereas the test-retest reliability and inter-rater reliability showed an excellent and good agreement of 0.90 and 0.86, respectively. Best-estimate clinical diagnosis-SCID diagnosis agreement was acceptable at 0.76. The sensitivity, specificity, positive and negative predictive values were 0.91, 0.86, 0.83, and 0.93, respectively. CONCLUSION. The Chinese version of the SCID-II ASPD subscale is reliable and valid for diagnosing ASPD in a Cantonese-speaking clinical population.

Transuranium perrhenates: Np(IV), Pu(IV) and (III), Am (III)

International Nuclear Information System (INIS)

Silvestre, Jean-Paul; Freundlich, William; Pages, Monique

1977-01-01

Synthesis in aqueous solution and by solid state reactions, crystallographical characterization and study of the stability of some transuranium perrhenates: Asup(n+)(ReO 4 - )sub(n) (A=Np(IV), Pu(IV), Pu(III), Am(III) [fr

Technical Survey and Feasibility Review for Development of IV-CEAPI

International Nuclear Information System (INIS)

Jang, Yongtae; Park, Jinseok; Lee, Myounggoo; Cho, Yeonho; Kim, Hyunmin

2016-01-01

The purpose of this paper is to establish the development direction of the IV-CEAPI(Control element assembly position indicator). The paper presents the technologies of the existing CEAPI and other linear displacement sensors. The paper also presents feasibility review of those technologies for the IV-CEAPI considering its environmental conditions as shown in Table 1. an instrument to monitor vertical position of the control element assembly (CEA) in nuclear reactors. The CEAPI is installed in each control element drive mechanism (CEDM). The conventional CEDMs are installed outside the reactor vessel (RV) with nozzles penetrating the RV head. To select the type of the IV-CEAPI, technical surveys on linear displacement sensors were performed. Feasibility of those sensors was reviewed considering the environment conditions, experience, reliability and simplicity. The result is summarized in Table 2 which implies that the solenoid type is considered to be the best suitable types for the IV-CEAPI

Phase II study of ipilimumab in adolescents with unresectable stage III or IV malignant melanoma

DEFF Research Database (Denmark)

Geoerger, Birgit; Bergeron, Christophe; Gore, Lia

2017-01-01

BACKGROUND: Ipilimumab is approved for the treatment of advanced melanoma in adults; however, little information on the efficacy and safety of ipilimumab in younger patients is available. METHODS: Patients aged 12 to <18 years with previously treated or untreated, unresectable stage III or IV mal...

Operating and test experience of EBR-II

International Nuclear Information System (INIS)

Sackett, J.I.

1991-01-01

EBR-II has operated for 27 years, the longest for any Liquid Metal Reactor (LMR) power plant. During that time, much has been learned about successful LMR operation and design. The basic lesson is that conservatism in design can pay significant dividends in operating reliability. Furthermore, such conservatism need not mean high cost. The EBR-II system emphasizes simplicity, minimizing the number of valves in the heat transport system, for example, and simplifying the primary heat-transport-system layout. Another lesson is that emphasizing reliability of the steam generating system at the sodium-water interface (by using duplex tubes in the case of EBR-II) has been well worth the higher initial costs; no problems with leakage have been encountered in EBR-II's operating history. Locating spent fuel storage in the primary tank and providing for decay heat removal by natural connective flow have also been contributors to EBR-II's success. The ability to accommodate loss of forced cooling or loss of heat sink passively has resulted in benefits for simplification, primarily through less reliance on emergency power and in not requiring the secondary sodium or steam systems to be safety grade. Also, the 'piped-pool' arrangement minimizes thermal stress to the primary tank and enhances natural convective flow. These benefits have been realized through a history of operation that has seen EBR-II evolve through four major phases in its test programs, culminating in its present mission as the Integral Fast Reactor (IFR) prototype. (author)

Design and Implementation of an Embedded NIOS II System for JPEG2000 Tier II Encoding

Directory of Open Access Journals (Sweden)

John M. McNichols

2013-01-01

Full Text Available This paper presents a novel implementation of the JPEG2000 standard as a system on a chip (SoC. While most of the research in this field centers on acceleration of the EBCOT Tier I encoder, this work focuses on an embedded solution for EBCOT Tier II. Specifically, this paper proposes using an embedded softcore processor to perform Tier II processing as the back end of an encoding pipeline. The Altera NIOS II processor is chosen for the implementation and is coupled with existing embedded processing modules to realize a fully embedded JPEG2000 encoder. The design is synthesized on a Stratix IV FPGA and is shown to out perform other comparable SoC implementations by 39% in computation time.

Preliminary Results from the PrimEx-II experiment at Jefferson Lab

Energy Technology Data Exchange (ETDEWEB)

Gasparian, Ashot [NCA& T, Greensboro, NC; Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States)

2016-06-01

Properties of the neutral pion, as the lightest hadron in Nature, are most sensitive to the basic symmetries and their partial breaking effects in the theory of the strong interaction (QCD). In particular, the po →gg decay width is primarily defined by the spontaneous chiral symmetry breaking effect (chiral anomaly) in QCD. The next order corrections to the anomaly have been shown to be small and are known to a 1% precision level. The PrimEx Collaboration at JLab has developed and performed two Primakoff type experiments to measure the po →gg decay width with a similar precision. The published result from the PrimEx-I experiment, G(p0 →gg ) = 7.82±0.14 (stat.)±0.17 (syst.) eV, was a factor of two more precise than the average value quoted in PDG-2010 [1]. The second experiment was performed in 2010 with a goal of 1.4% total uncertainty to address the next-to-leading-order theory calculations. The preliminary results from the PrimEx-II experiment are presented and discussed in this note.

Validez de constructo de los trastornos de la personalidad del DSM-IV

Directory of Open Access Journals (Sweden)

José Luis Besteiro

2004-01-01

Full Text Available El objetivo de este estudio cuasi-experimental fue valorar la validez de constructo de los conglomerados de trastornos de la personalidad del DSM-IV y la posible existencia de alguna de las dimensiones propuestas por los modelos factorialesbiológicos de la personalidad. Para ello se analizó la estructura factorial que emerge de un conjunto de medidas clínicas (MCMI-II, de personalidad (BFQ, psicofisiológicas (tasa cardiaca y respuesta dermoeléctrica ante tareas de estrés experimental y neuropsicológicas (tareas informatizadas que evalúan funciones ejecutivas frontales de atención sostenida, flexibilidad mental y formación de conceptos: Stroop, CPT y WCST. Se analizó una muestra de 146 sujetos (68 varones y 78 mujeres de edades comprendidas entre 17 y 65 años, diagnosticados con algún trastorno de la personalidad según criterios del DSM-IV. No se ha encontrado ningún factor que responda a alguna de las dimensiones propuestas por los modelos factoriales-biológicos para explicar los trastornos de la personalidad ni a la estructura de conglomerados del DSM-IV. Los resultados no apoyan la validez de constructo de los trastornos de la personalidad del DSM-IV.

Sigmoid Diverticulitis: Our Experiences with 13 Patients

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Ahmet Fikret Yücel,

2012-03-01

Full Text Available Objective: We aimed to present our treatment approach and results of the treatment in patients with the diagnosis of sigmoid diverticulitis. Material and Methods: In this study, we evaluated patients who presented to the emergency unit between March 2009 and February 2010 and have been diagnosed with sigmoid diverticulitis. The data were prospectively collected and retrospectively analyzed. Our patients were classified and staged according to Hinchey’s classification system. The results of the treatment, complication rates, and duration of hospitalization were presented in the light of the literature. Results: Thirteen patients (9 males, 4 females with a mean age of 52 years and median age of 58 (35-58 years were diagnosed with sigmoid diverticulitis. Five patients underwent laparotomy (Hinchey III-IV, while Hartmann’s procedure was carried out in 4 patients and resection and primer anastomosis was performed in 1 patient. Eight patients who were classified as Hinchey I-II (diverticulitis-abscess were followed up with medical treatment. The mean duration of hospitalization was 8.6 (4-21 days and 17.4 (10-27 days days in Hinchey I-II and III-IV groups, respectively. All patients in the laparotomy group developed at least one complication. Conclusion: Hinchey stage III-IV sigmoid diverticulitis requires laparotomy. Complication rates are higher and duration of hospitalization is longer in patients with Hinchey stage III-IV when compared to those with Hinchey I-II. We conclude that Hinchey stage I-II diverticulitis can be successfully managed with medical treatment. (The Me di cal Bul le tin of Ha se ki 2012; 50: 21-4

Coordination and solvent extraction behaviour of oxozirconium(IV), thorium(IV) and dioxouranium(VI)

International Nuclear Information System (INIS)

Dash, K.C.

1989-01-01

The systematic liquid-liquid extraction behaviour of oxozirconium (IV), thorium(IV) and dioxouranium(VI) have been investigated using a number of synthesised and commercial chelating extractants. The synergism or antagonism for these processes in presence of neutral donor ligands have also been identified and the conditions for separation and isolation of pure individual metal ions have been established. The coordination behaviour of oxozirconium(IV), thorium(IV) and dioxouranium(VI) with a large number of mono- and polydentate ligands have been studied. With oxozirconium(IV), invariably always a cyclic, tetranuclear species is obtained, derived from the tetrameric structure of the parent ZrOCl 2 .8H 2 O which is actually (Zr 4 (OH) 8 (H 2 O) 16 )Cl 8 .12H 2 O. No simple, monomeric oxozirconium(IV) complex was obtained. Uranium(VI) and thorium(IV) form a wide variety of complexes of higher coordination numbers and several bi- and trinuclear complexes were also characterised where the two adjacent metal centres are joined to each other by a double hydroxo-bridge. (author). 69 refs., 3 figs., 4 tabs

Design of fractional order differentiator using type-III and type-IV discrete cosine transform

Directory of Open Access Journals (Sweden)

Manjeet Kumar

2017-02-01

Full Text Available In this paper, an interpolation method based on discrete cosine transform (DCT is employed for digital finite impulse response-fractional order differentiator (FIR-FOD design. Here, a fractional order digital differentiator is modeled as finite impulse response (FIR system to get an optimized frequency response that approximates the ideal response of a fractional order differentiator. Next, DCT-III and DCT-IV are utilized to determine the filter coefficients of FIR filter that compute the Fractional derivative of a given signal. To improve the frequency response of the proposed FIR-FOD, the filter coefficients are further modified using windows. Several design examples are presented to demonstrate the superiority of the proposed method. The simulation results have also been compared with the existing FIR-FOD design methods such as DFT interpolation, radial basis function (RBF interpolation, DCT-II interpolation and DST interpolation methods. The result reveals that the proposed FIR-FOD design technique using DCT-III and DCT-IV outperforms DFT interpolation, RBF interpolation, DCT-II interpolation and DST interpolation methods in terms of magnitude error.

Genetic analysis of a Chinese family with members affected with Usher syndrome type II and Waardenburg syndrome type IV.

Science.gov (United States)

Wang, Xueling; Lin, Xiao-Jiang; Tang, Xiangrong; Chai, Yong-Chuan; Yu, De-Hong; Chen, Dong-Ye; Wu, Hao

2017-11-01

The purpose of this study was to identify the genetic causes of a family presenting with multiple symptoms overlapping Usher syndrome type II (USH2) and Waardenburg syndrome type IV (WS4). Targeted next-generation sequencing including the exon and flanking intron sequences of 79 deafness genes was performed on the proband. Co-segregation of the disease phenotype and the detected variants were confirmed in all family members by PCR amplification and Sanger sequencing. The affected members of this family had two different recessive disorders, USH2 and WS4. By targeted next-generation sequencing, we identified that USH2 was caused by a novel missense mutation, p.V4907D in GPR98; whereas WS4 due to p.V185M in EDNRB. This is the first report of homozygous p.V185M mutation in EDNRB in patient with WS4. This study reported a Chinese family with multiple independent and overlapping phenotypes. In condition, molecular level analysis was efficient to identify the causative variant p.V4907D in GPR98 and p.V185M in EDNRB, also was helpful to confirm the clinical diagnosis of USH2 and WS4. Copyright © 2017 Elsevier B.V. All rights reserved.

Removal of uranium(VI) from the aqueous phase by iron(II) minerals in presence of bicarbonate

Energy Technology Data Exchange (ETDEWEB)

Regenspurg, Simona, E-mail: regens@gfz-potsdam.de [Industrial Ecology, Royal Institute of Technology (KTH), SE 10044 Stockholm (Sweden); Schild, Dieter; Schaefer, Thorsten; Huber, Florian [Institut fuer Nukleare Entsorgung (INE), Forschungszentrum Karlsruhe, 76344 Eggenstein-Leopoldshafen (Germany); Malmstroem, Maria E. [Industrial Ecology, Royal Institute of Technology (KTH), SE 10044 Stockholm (Sweden)

2009-09-15

Uranium(VI) mobility in groundwater is strongly affected by sorption of mobile U(VI) species (e.g. uranyl, UO{sub 2}{sup 2+}) to mineral surfaces, precipitation of U(VI) compounds, such as schoepite (UO{sub 2}){sub 4}O(OH){sub 6}.6H{sub 2}O), and by reduction to U(IV), forming sparingly soluble phases (uraninite; UO{sub 2}). The latter pathway, in particular, would be very efficient for long-term immobilization of U. In nature, Fe(II) is an important reducing agent for U(VI) because it frequently occurs either dissolved in natural waters, sorbed to matrix minerals, or structurally bound in many minerals. Redox reactions between U(VI) and Fe(II) depend not only on the availability of Fe(II) in the environment, but also on the chemical conditions in the aqueous solution. Under natural groundwater condition U(VI) forms complexes with many anionic ligands, which strongly affect its speciation. Carbonate, in particular, is known to form stable complexes with U, raising the question, if U(VI), when complexed by carbonate, can be reduced to UO{sub 2}. The goal of this study was to find out if Fe(II) when structurally bound in a mineral (as magnetite, Fe{sub 3}O{sub 4}) or sorbed to a mineral surface (as corundum, Al{sub 2}O{sub 3}) can reduce U(VI) to U(IV) in the presence of HCO{sub 3}{sup -}. Batch experiments were conducted under anaerobic conditions to observe U removal from the aqueous phase by the two minerals depending on HCO{sub 3}{sup -} addition (1 mM), U concentration (0.01-30 {mu}M) and pH value (6-10). Immediately after the experiments, the mineral surfaces were analyzed by X-ray photoelectron spectroscopy (XPS) to obtain information on the redox state of U bound to the solid surfaces. XPS results gave evidence that U(VI) can be reduced both by magnetite and by corundum amended with Fe(II). In the presence of HCO{sub 3}{sup -} the amount of reduced U on the mineral surfaces increased compared to carbonate-free solutions. This can be explained by the formation

Adsorption of Pb(II), Cu(II), Cd(II), Zn(II), Ni(II), Fe(II), and As(V) on bacterially produced metal sulfides.

Science.gov (United States)

Jong, Tony; Parry, David L

2004-07-01

The adsorption of Pb(II), Cu(II), Cd(II), Zn(II), Ni(II), Fe(II) and As(V) onto bacterially produced metal sulfide (BPMS) material was investigated using a batch equilibrium method. It was found that the sulfide material had adsorptive properties comparable with those of other adsorbents with respect to the specific uptake of a range of metals and, the levels to which dissolved metal concentrations in solution can be reduced. The percentage of adsorption increased with increasing pH and adsorbent dose, but decreased with increasing initial dissolved metal concentration. The pH of the solution was the most important parameter controlling adsorption of Cd(II), Cu(II), Fe(II), Ni(II), Pb(II), Zn(II), and As(V) by BPMS. The adsorption data were successfully modeled using the Langmuir adsorption isotherm. Desorption experiments showed that the reversibility of adsorption was low, suggesting high-affinity adsorption governed by chemisorption. The mechanism of adsorption for the divalent metals was thought to be the formation of strong, inner-sphere complexes involving surface hydroxyl groups. However, the mechanism for the adsorption of As(V) by BPMS appears to be distinct from that of surface hydroxyl exchange. These results have important implications to the management of metal sulfide sludge produced by bacterial sulfate reduction.

Theory of electron cyclotron heating in the Constance II experiment

International Nuclear Information System (INIS)

Mauel, M.E.

1981-03-01

The bounce-averaged quasi-linear equation for a non-relativistic mirror-confined plasma interacting with electromagnetic waves is derived for use in the study of ECRH of the Constance II mirror experiment. The derivations follows the more formal examples given by Berk for electrostatic waves and Bernstein and Baxter for relativistic plasmas. The validity of the theory is discussed by examining individual particle orbits in an EM field. The local dispersion relation is found while deriving a self-consistent WKB theory which can be used to estimate the power transferred from the launching horn to the plasma

Forces necessary for the disruption of the cisternal segments of cranial nerves II through XII.

Science.gov (United States)

Tubbs, R Shane; Wellons, John C; Blount, Jeffrey P; Salter, E George; Oakes, W Jerry

2007-04-01

Manipulation of the cisternal segment of cranial nerves is often performed by the neurosurgeon. To date, attempts at quantifying the forces necessary to disrupt these nerves in situ, to our knowledge, has not been performed. The present study seeks to further elucidate the forces necessary to disrupt the cranial nerves while within the subarachnoid space. The cisternal segments of cranial nerves II through XII were exposed in six unfixed cadavers, all less than 6 hr postmortem. Forces to failure were then measured. Mean forces necessary to disrupt nerves for left sides in increasing order were found for cranial nerves IX, VII, IV, X, XII, III, VIII, XI, VI, V, and II, respectively. Mean forces for right-sided cranial nerves in increasing order were found for cranial nerves IX, VII, IV, X, XII, VIII, V, VI, XI, III, and II, respectively. Overall, cranial nerves requiring the least amount of force prior to failure included cranial nerves IV, VII, and IX. Those requiring the highest amount of force included cranial nerves II, V, VI, and XI. There was an approximately ten-fold difference between the least and greatest forces required to failure. Cranial nerve III was found to require significantly (P cranial nerves II through XII. We found that cranial nerve IX consistently took the least amount of force until its failure and cranial nerve II took the greatest. Other cranial nerves that took relatively small amount of force prior to failure included cranial nerves IV and VII. Although in vivo damage can occur prior to failure of a cranial nerve, our data may serve to provide a rough estimation for the maximal amount of tension that can be applied to a cranial nerve that is manipulated while within its cistern.

Discharge initiation experiments in the Tokapole II tokamak

International Nuclear Information System (INIS)

Shepard, D.A.

1984-06-01

Experiments in the Tokapole II tokamak demonstrate the benefits of high density (n/sub e//n 0 greater than or equal to 0.01) preionization by reducing four quantities at startup: necessary toroidal loop voltage (V 1 ) (50%), volt-second consumption (40 to 50%), impurity radiation (25 to 50%), and runaway electron production (approx. 80 to 100%). A zero-dimensional code models the loop voltage reduction dependence on preionization density and predicts a similar result for reactor scale devices. The code shows low initial resistivity and a high resistivity time derivative contribute to loop voltage reduction. The power balance of the ECR plasma in a toroidal-field-only case was studied. Langmuir probes and impurity doping were used. The vertical electric field (E/sub v/) and current (I/sub v/), which result from curvature drift, were measured (E/sub v/ approx. 10 V/cm and I/sub v/ approx. 50 Amps) and exceeded expected values for the bulk electron temperature (approx. 10 eV). A series of experiments with external windings to simulate field errors perpendicular to the toroidal field was done. The results imply that an error field of 0.1% of the toroidal field is deleterious to ECR plasma density

Generation of dipeptidyl peptidase IV (DPP-IV) inhibitory peptides during the enzymatic hydrolysis of tropical banded cricket (Gryllodes sigillatus) proteins.

Science.gov (United States)

Nongonierma, Alice B; Lamoureux, Candice; FitzGerald, Richard J

2018-01-24

Tropical banded crickets (Gryllodes sigillatus) were studied for their ability to yield hydrolysates with dipeptidyl peptidase IV (DPP-IV) inhibitory properties. A cricket protein isolate (CPI) was prepared following extraction of the water soluble proteins from G. sigillatus powder (CP). The extraction yield and purity were 20.90 ± 0.35% and 57.0 ± 2.23%, respectively. Endogenous proteinase activities were detected in the CP, which were linked to the significant protein breakdown seen in this sample. Fifteen CPI hydrolysates (H1-H15) were generated with Protamex™ using a design of experiments (DOE) approach combining three parameters, temperature (40, 50 and 60 °C), enzyme to substrate ratio (E : S, 0.50, 1.25 and 2.00% (w/w)) and hydrolysis time (60, 150 and 240 min). The DPP-IV half maximal inhibitory concentrations (IC 50 ) of the CPI hydrolysates ranged from 0.40 ± 0.03/0.40 ± 0.02 (H2/H3) to 1.01 ± 0.07 mg mL -1 (H7). Following simulated gastrointestinal digestion (SGID), the DPP-IV IC 50 of CPI decreased (>3.57 vs. 0.78 ± 0.04 mg mL -1 ) while that of H5 increased (0.47 ± 0.03 vs. 0.71 ± 0.06 mg mL -1 ). This study has demonstrated for the first time that G. sigillatus protein hydrolysates are able to inhibit DPP-IV. The study of these hydrolysates in vivo is needed to evaluate their potential role in glycaemic management.

Incidental Learning: A Brief, Valid Measure of Memory Based on the WAIS-IV Vocabulary and Similarities Subtests.

Science.gov (United States)

Spencer, Robert J; Reckow, Jaclyn; Drag, Lauren L; Bieliauskas, Linas A

2016-12-01

We assessed the validity of a brief incidental learning measure based on the Similarities and Vocabulary subtests of the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV). Most neuropsychological assessments for memory require intentional learning, but incidental learning occurs without explicit instruction. Incidental memory tests such as the WAIS-III Symbol Digit Coding subtest have existed for many years, but few memory studies have used a semantically processed incidental learning model. We conducted a retrospective analysis of 37 veterans with traumatic brain injury, referred for outpatient neuropsychological testing at a Veterans Affairs hospital. As part of their evaluation, the participants completed the incidental learning tasks. We compared their incidental learning performance to their performance on traditional memory measures. Incidental learning scores correlated strongly with scores on the California Verbal Learning Test-Second Edition (CVLT-II) and Brief Visuospatial Memory Test-Revised (BVMT-R). After we conducted a partial correlation that controlled for the effects of age, incidental learning correlated significantly with the CVLT-II Immediate Free Recall, CVLT-II Short-Delay Recall, CVLT-II Long-Delay Recall, and CVLT-II Yes/No Recognition Hits, and with the BVMT-R Delayed Recall and BVMT-R Recognition Discrimination Index. Our incidental learning procedures derived from subtests of the WAIS-IV Edition are an efficient and valid way of measuring memory. These tasks add minimally to testing time and capitalize on the semantic encoding that is inherent in completing the Similarities and Vocabulary subtests.

Synthesis of Reusable Silica Nanosphere-Supported Pt(IV Complex for Formation of Disulfide Bonds in Peptides

Directory of Open Access Journals (Sweden)

Xiaonan Hou

2017-02-01

Full Text Available Some peptide-based drugs, including oxytocin, vasopressin, ziconotide, pramlintide, nesiritide, and octreotide, contain one intramolecular disulfide bond. A novel and reusable monodispersed silica nanosphere-supported Pt(IV complex (SiO2@TPEA@Pt(IV; TPEA: N-[3-(trimethoxysilylpropyl]ethylenediamine was synthesized via a four-step procedure and was used for the formation of intramolecular disulfide bonds in peptides. Transmission electron microscopy (TEM and chemical mapping results for the Pt(II intermediates and for SiO2@TPEA@Pt(IV show that the silica nanospheres possess a monodisperse spherical structure and contain uniformly-distributed Si, O, C, N, Cl, and Pt. The valence state of Pt on the silica nanospheres was characterized by X-ray photoelectron spectroscopy (XPS. The Pt(IV loaded on SiO2@TPEA@Pt(IV was 0.15 mmol/g, as determined by UV-VIS spectrometry. The formation of intramolecular disulfides in six dithiol-containing peptides of variable lengths by the use of SiO2@TPEA@Pt(IV was investigated, and the relative oxidation yields were determined by high-performance liquid chromatography (HPLC. In addition, peptide 1 (Ac-CPFC-NH2 was utilized to study the reusability of SiO2@TPEA@Pt(IV. No significant decrease in the relative oxidation yield was observed after ten reaction cycles. Moreover, the structure of SiO2@TPEA@Pt(IV after being used for ten cycles was determined to be similar to its initial one, demonstrating the cycling stability of the complex.

Transport properties of gaseous ions over a wide energy range, IV

International Nuclear Information System (INIS)

Viehland, L.A.; Mason, E.A.

1995-01-01

This paper updates three previous papers entitled open-quotes Transport Properties of Gaseous Ions over a Wide Energy Range.close quotes. These papers referred to as Parts I, II, and III, were by H.W.Ellis, P.Y. Pai, E.W. McDaniel, E.A. Mason, and L.A. Viehland, S.L. Lin, M.G. Thackston. Part IV contains compilations of experimental data on ionic mobilities and diffusion coefficients (both longitudinal and transverse) for ions in neutral gases in an externally applied electrostatic field, at various gas temperatures; the data are tabulated as a function of the ionic energy parameter E/N, where E is the electric field strength and N is the number density of the neutral gas. Part IV also contains a locator key to ionic mobilities and diffusion coefficients compiled in Parts I-IV. The coverage of the literature extends into 1994. The criteria for selection of the data are; (1) the measurements must cover a reasonably wide range of E/N; (2) the identity of the ions must be well established; and (3) the accuracy of the data must be good. 26 refs., 6 tabs

The bi-directional associations between psychotic experiences and DSM-IV mental disorders

Science.gov (United States)

McGrath, John J.; Saha, Sukanta; Al-Hamzawi, Ali; Andrade, Laura; Benjet, Corina; Bromet, Evelyn J.; Browne, Mark Oakley; Caldas de Almeida, Jose M.; Chiu, Wai Tat; Demyttenaere, Koen; Fayyad, John; Florescu, Silvia; de Girolamo, Giovanni; Gureje, Oye; Haro, Josep Maria; Have, Margreet ten; Hu, Chiyi; Kovess-Masfety, Viviane; Lim, Carmen C. W.; Navarro-Mateu, Fernando; Sampson, Nancy; Posada-Villa, José; Kendler, Kenneth; Kessler, Ronald C.

2016-01-01

Objective While it is now recognized that psychotic experiences (PEs) are associated with an increased risk of later mental disorders, we lack a detailed understanding of the reciprocal time-lagged relationships between first onsets of PEs and mental disorders. Methods The WHO World Mental Health (WMH) surveys assessed lifetime prevalence and age-of-onset of PEs and 21 common DSM-IV mental disorders among 31,261 adult respondents from 18 countries. Results Temporally primary PEs were significantly associated with subsequent first onset of 8 of the 21 mental disorders (major depressive disorder, bipolar disorder, generalized anxiety disorder, social phobia, post-traumatic stress disorder, adult separation anxiety disorder, bulimia nervosa, alcohol abuse), with ORs (95%CI) ranging from 1.3 (1.2–1.5; major depressive disorder) to 2.0 (1.5–2.6; bipolar disorder). In contrast, 18 of 21 primary mental disorders were significantly associated with subsequent first onset of PEs, with ORs (95% CI) ranging from 1.5 (1.0–2.1; childhood separation anxiety disorder) to 2.8 (1.0–7.8; anorexia nervosa). Conclusions While temporally primary PEs are associated with an elevated risk of several subsequent mental disorders, we found that most mental disorder are associated with an elevated risk of subsequent PEs. Further investigation of the underlying factors accounting for these time-order relationships might shed light on the etiology of PEs. PMID:26988628

Kinetics of the reduction of plutonium(IV) by hydroxyurea, a novel salt-free agent

International Nuclear Information System (INIS)

Zhu Zhaowu; He Jianyu; Zhang Zefu; Zhang Yu; Zheng Weifang

2004-01-01

The kinetics of the reduction of plutonium(IV) by hydroxyurea (HU), a novel salt free reductant, in nitric acid solutions has been studied. The observed reaction rate can be expressed as: -d[Pu(IV)]/dt=k 0 [Pu(IV)] 2 [HU]/[H + ] 0.9 , where k 0 = 5853 ± 363 (l 1.1 x mol -1.1 x s -1 ) at t = 13 deg C. The activation energy is about 81.2 kJ/mol. It was also shows that uranium(VI) has no appreciable influence on the reaction rate. Compared with other organic reductants our experiments indicate that HU is a very fast reductant for plutonium(IV). (author)

The generation, validation and testing of a coupled 219-group neutron 36-group gamma ray AMPX-II library

International Nuclear Information System (INIS)

Panini, G.C.; Siciliano, F.; Lioi, A.

1987-01-01

The main characteristics of a P 3 coupled 219-group neutron 36-group gamma-ray library in the AMPX-II Master Interface Format obtained processing ENDF/B-IV data by means of various AMPX-II System modules are presented in this note both for the more reprocessing aspects and features of the generated component files-neutrons, photon and secondary gamma-ray production cross sections. As far as the neutron data are concerned there is the avaibility of 186 data sets regarding most significant fission products. Results of the additional validation of the neutron data pertaining to eighteen benchmark experiments are also given. Some calculational tests on both neutron and coupled data emphasize the important role of the secondary gamma-ray data in nuclear criticality safety calculations

Incorporation of sulfate or selenate groups into oxotellurates(IV). I. Calcium, cadmium, and strontium compounds

International Nuclear Information System (INIS)

Weil, Matthias; Shirkhanlou, Mahdi

2017-01-01

Seven new mixed oxochalcogenate compounds in the systems M II /X VI /Te IV /O/(H), (M II = Ca, Cd, Sr; X VI = S, Se) were obtained under hydrothermal conditions (210 C, one week). Crystal structure determinations based on single-crystal X-ray diffraction data revealed the compositions Ca 3 (SeO 4 )(TeO 3 ) 2 , Ca 3 (SeO 4 )(Te 3 O 8 ), Cd 3 (SeO 4 )(Te 3 O 8 ), Cd 3 (H 2 O)(SO 4 )(Te 3 O 8 ), Cd 4 (SO 4 )(TeO 3 ) 3 , Cd 5 (SO 4 ) 2 (TeO 3 ) 2 (OH) 2 , and Sr 3 (H 2 O) 2 (SeO 4 )(TeO 3 ) 2 for these phases. Peculiar features of the crystal structures of Ca 3 (SeO 4 )(TeO 3 ) 2 , Ca 3 (SeO 4 )(Te 3 O 8 ), Cd 3 (SeO 4 )(Te 3 O 8 ), Cd 3 (H 2 O)(SO 4 )(Te 3 O 8 ), and Sr 3 (H 2 O) 2 (SeO 4 )(TeO 3 ) 2 are metal-oxotellurate(IV) layers connected by bridging XO 4 tetrahedra and/or by hydrogen-bonding interactions involving hydroxyl or water groups, whereas Cd 4 (SO 4 )(TeO 3 ) 3 and Cd 5 (SO 4 ) 2 (TeO 3 ) 2 (OH) 2 crystallize as framework structures. Common to all crystal structures is the stereoactivity of the Te IV electron lone pair for each oxotellurate(IV) unit, pointing either into the inter-layer space, or into channels and cavities in the crystal structures. (copyright 2017 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

Synthesis and characterization of chiral thorium(IV) and uranium(IV) benzamidinate complexes

Energy Technology Data Exchange (ETDEWEB)

Schoene, Sebastian; Maerz, Juliane; Kaden, Peter; Patzschke, Michael; Ikeda-Ohno, Atsushi [Helmholtz-Zentrum Dresden-Rossendorf e.V., Dresden (Germany). Chemistry of the F-Elements

2017-06-01

Two chiral benzamidinate complexes of tetravalent actinides (Th(IV) and U(IV)) were synthesized using a salt metathesis reaction of the corresponding actinide(IV) tetrachlorides and the potassium salt of the chiral benzamidine (S,S)-N,N-Bis-(1-phenylethyl)-benzamidine ((S)-HPEBA). The structure of the complexes was determined with single crystal X-ray diffraction. These are the first examples of chiral amidinate complexes of actinides.

Päiväkoti Riemula

OpenAIRE

Alanko, Reetta; Ihanamäki, Katja

2012-01-01

Opinnäytetyössä kuvataan yleisesti päivähoidon kehitystä Suomessa sekä päivähoitoa yrittäjän näkökulmasta, tuoden esille sen tämän päivän haasteet ja mahdollisuudet. Työssä on pohdittu yhteistyön merkitystä kunnan kanssa ja sitä, miten kunta voi osaltaan joko rajoittaa tai edesauttaa yksityisen päivähoitoyrityksen toimintaa. Opinnäytetyössä kerrotaan teoriassa Päiväkoti Riemula nimisen, erityispäivähoitopalveluita tarjoavan yrityksen perustamiseen liittyvistä suunnitelmista. Suunnitelluss...

Critical bias fields for tilting stability in the BETA-II experiment

International Nuclear Information System (INIS)

Dalhed, H.E.

1981-01-01

The PEST equilibrium code and the GATO ideal MHD stability code have been modified to study stability properties of Spheromak configurations. Of particular interest is the effect on tilting modes of perfectly conducting walls which do not link the plasma. This paper makes use of equilibria and conducting walls specifically designed to model the BETA-II experiment at LLNL. Onset of the tilting mode is determined as a function of the bias magnetic field. Comparison with available experimental data shows promising agreement with the numerical results

Radioheliograph observations of a pulsating structure associated with a moving type IV burst

International Nuclear Information System (INIS)

Pick, M.; Trottet, G.

1978-01-01

Observations of a pulsating structure with the Mark II Nancay Radioheliograph are reported. These fluctuations are found to occur early in the development of a moving type IV burst. It is confirmed that the source of these fluctuations is of small extent and that it is embedded in the moving type IV continuum, plausibly at the top of an expanding arch. The observations suggest that the pulsating structure consists of recurrent enhanced pulses (mean recurrency time 1.7 s) followed by trains of periodic pulses (mean periodicity 0.37 s). The intensity of the mean enhanced pulses has a damping time of about 5 s. It is shown that previous interpretation of the pulsating structure by Rosenberg (1970) cannot account for the present observations. (Auth.)

Investigation on the electrode process of the Mn(II)/Mn(III) couple in redox flow battery

International Nuclear Information System (INIS)

Xue Fangqin; Wang Yongliang; Wang Wenhong; Wang Xindong

2008-01-01

The Mn(II)/Mn(III) couple has been recognized as a potential anode for redox flow batteries to take the place of the V(IV)/V(V) in all-vanadium redox battery (VRB) and the Br 2 /Br - in sodium polysulfide/bromine (PSB) because it has higher standard electrode potential. In this study, the electrochemical behavior of the Mn(II)/Mn(III) couple on carbon felt and spectral pure graphite were investigated by cyclic voltammetry, steady polarization curve, electrochemical impedance spectroscopy, transient potential-step experiment, X-ray diffraction and charge-discharge experiments. Results show that the Mn(III) disproportionation reaction phenomena is obvious on the carbon felt electrode while it is weak on the graphite electrode owing to its fewer active sites. The reaction mechanism on carbon felt was discussed in detail. The reversibility of Mn(II)/Mn(III) is best when the sulfuric acid concentration is 5 M on the graphite electrode. Performance of a RFB employing Mn(II)/Mn(III) couple as anolyte active species and V(III)/V(II) as catholyte ones was evaluated with constant-current charge-discharge tests. The average columbic efficiency is 69.4% and the voltage efficiency is 90.4% at a current density of 20 mA cm -2 . The whole energy efficiency is 62.7% close to that of the all-vanadium battery and the average discharge voltage is about 14% higher than that of an all-vanadium battery. The preliminary exploration shows that the Mn(II)/Mn(III) couple is electrochemically promising for redox flow battery

Data report for ROSA-IV LSTF gravity-driven safety injection experiment run SB-CL-27

International Nuclear Information System (INIS)

Yonomoto, Taisuke; Saitou, Seishi; Kuroda, Takeshi

1994-03-01

Experimental data are presented for the passive injection test, Run SB-CL-27, conducted at the ROSA-IV Large Scale Test Facility (LSTF) on September 17, 1992. This experiment simulated thermal-hydraulic behavior of a gravity-driven, passive safety injection system during a small-break loss-of-coolant accident (LOCA) in a pressurized water reactor (PWR). The injection system consisted of a gravity-driven injection tank, located above the reactor vessel, with connecting lines. The tank was initially filled with water of room temperature at the same pressure as the pressurizer. The connecting lines to the cold leg and to the vessel downcomer were opened at the test initiation. Then, a natural circulation flow developed in the loop which was formed by these lines and the injection tank. The hot water in the cold leg circulated into the upper part of tank and accumulated there causing a significant thermal stratification. This thermal stratification prevented direct-contact condensation of steam from occurring during the subsequent tank drain-down phase. Therefore, no condensation-induced depressurization of the tank, affecting adversely the injection performance, occurred. (author)

Operational-safety advantages of LMFBR's: the EBR-II experience and testing program

International Nuclear Information System (INIS)

Sackett, J.I.; Lindsay, R.W.; Golden, G.H.

1982-01-01

LMFBR's contain many inherent characteristics that simplify control and improve operating safety and reliability. The EBR-II design is such that good advantage was taken of these characteristics, resulting in a vary favorable operating history and allowing for a program of off-normal testing to further demonstrate the safe response of LMFBR's to upsets. The experience already gained, and that expected from the future testing program, will contribute to further development of design and safety criteria for LMFBR's. Inherently safe characteristics are emphasized and include natural convective flow for decay heat removal, minimal need for emergency power and a large negative reactivity feedback coefficient. These characteristics at EBR-II allow for ready application of computer diagnosis and control to demonstrate their effectiveness in response to simulated plant accidents. This latter testing objective is an important part in improvements in the man-machine interface

Thermodynamic description of Tc(iv) solubility and carbonate complexation in alkaline NaHCO3-Na2CO3-NaCl systems.

Science.gov (United States)

Baumann, A; Yalçıntaş, E; Gaona, X; Polly, R; Dardenne, K; Prüßmann, T; Rothe, J; Altmaier, M; Geckeis, H

2018-03-28

The solubility of 99 Tc(iv) was investigated in dilute to concentrated carbonate solutions (0.01 M ≤ C tot ≤ 1.0 M, with C tot = [HCO 3 - ] + [CO 3 2- ]) under systematic variation of ionic strength (I = 0.3-5.0 M NaHCO 3 -Na 2 CO 3 -NaCl-NaOH) and pH m (-log[H + ] = 8.5-14.5). Strongly reducing conditions (pe + pH m ≈ 2) were set with Sn(ii). Carbonate enhances the solubility of Tc(iv) in alkaline conditions by up to 3.5 log 10 -units compared to carbonate-free systems. Solvent extraction and XANES confirmed that Tc was kept as +IV during the timeframe of the experiments (≤ 650 days). Solid phase characterization performed by XAFS, XRD, SEM-EDS, chemical analysis and TG-DTA confirmed that TcO 2 ·0.6H 2 O(am) controls the solubility of Tc(iv) under the conditions investigated. Slope analysis of the solubility data in combination with solid/aqueous phase characterization and DFT calculations indicate the predominance of the species Tc(OH) 3 CO 3 - at pH m ≤ 11 and C tot ≥ 0.01 M, for which thermodynamic and activity models are derived. Solubility data obtained above pH m ≈ 11 indicates the formation of previously unreported Tc(iv)-carbonate species, possibly Tc(OH) 4 CO 3 2- , although the likely formation of additional complexes prevents deriving a thermodynamic model valid for this pH m -region. This work provides the most comprehensive thermodynamic dataset available for the system Tc 4+ -Na + -Cl - -OH - -HCO 3 - -CO 3 2- -H 2 O(l) valid under a range of conditions relevant for nuclear waste disposal.

Impeding 99Tc(IV) mobility in novel waste forms

Science.gov (United States)

Lee, Mal-Soon; Um, Wooyong; Wang, Guohui; Kruger, Albert A.; Lukens, Wayne W.; Rousseau, Roger; Glezakou, Vassiliki-Alexandra

2016-01-01

Technetium (99Tc) is an abundant, long-lived radioactive fission product whose mobility in the subsurface is largely governed by its oxidation state. Tc immobilization is crucial for radioactive waste management and environmental remediation. Tc(IV) incorporation in spinels has been proposed as a novel method to increase Tc retention in glass waste forms during vitrification. However, experiments under high-temperature and oxic conditions show reoxidation of Tc(IV) to volatile pertechnetate, Tc(VII). Here we examine this problem with ab initio molecular dynamics simulations and propose that, at elevated temperatures, doping with first row transition metal can significantly enhance Tc retention in magnetite in the order Co>Zn>Ni. Experiments with doped spinels at 700 °C provide quantitative confirmation of the theoretical predictions in the same order. This work highlights the power of modern, state-of-the-art simulations to provide essential insights and generate theory-inspired design criteria of complex materials at elevated temperatures. PMID:27357121

IV access in dental practice.

LENUS (Irish Health Repository)

Fitzpatrick, J J

2009-04-01

Intravenous (IV) access is a valuable skill for dental practitioners in emergency situations and in IV sedation. However, many people feel some apprehension about performing this procedure. This article explains the basic principles behind IV access, and the relevant anatomy and physiology, as well as giving a step-by-step guide to placing an IV cannula.

KENO-IV code benchmark calculation, (6)

International Nuclear Information System (INIS)

Nomura, Yasushi; Naito, Yoshitaka; Yamakawa, Yasuhiro.

1980-11-01

A series of benchmark tests has been undertaken in JAERI in order to examine the capability of JAERI's criticality safety evaluation system consisting of the Monte Carlo calculation code KENO-IV and the newly developed multigroup constants library MGCL. The present report describes the results of a benchmark test using criticality experiments about Plutonium fuel in various shape. In all, 33 cases of experiments have been calculated for Pu(NO 3 ) 4 aqueous solution, Pu metal or PuO 2 -polystyrene compact in various shape (sphere, cylinder, rectangular parallelepiped). The effective multiplication factors calculated for the 33 cases distribute widely between 0.955 and 1.045 due to wide range of system variables. (author)

THE HETDEX PILOT SURVEY. IV. THE EVOLUTION OF [O II] EMITTING GALAXIES FROM z ∼ 0.5 TO z ∼ 0

International Nuclear Information System (INIS)

Ciardullo, Robin; Gronwall, Caryl; Schneider, Donald P.; Zeimann, Gregory R.

2013-01-01

We present an analysis of the luminosities and equivalent widths of the 284 z 2 pilot survey for the Hobby-Eberly Telescope Dark Energy Experiment (HETDEX). By combining emission-line fluxes obtained from the Mitchell spectrograph on the McDonald 2.7 m telescope with deep broadband photometry from archival data, we derive each galaxy's dereddened [O II] λ3727 luminosity and calculate its total star formation rate. We show that over the last ∼5 Gyr of cosmic time, there has been substantial evolution in the [O II] emission-line luminosity function, with L* decreasing by ∼0.6 ± 0.2 dex in the observed function, and by ∼0.9 ± 0.2 dex in the dereddened relation. Accompanying this decline is a significant shift in the distribution of [O II] equivalent widths, with the fraction of high equivalent-width emitters declining dramatically with time. Overall, the data imply that the relative intensity of star formation within galaxies has decreased over the past ∼5 Gyr, and that the star formation rate density of the universe has declined by a factor of ∼2.5 between z ∼ 0.5 and z ∼ 0. These observations represent the first [O II]-based star formation rate density measurements in this redshift range, and foreshadow the advancements which will be generated by the main HETDEX survey.

Competing retention pathways of uranium upon reaction with Fe(II)

Science.gov (United States)

Massey, Michael S.; Lezama-Pacheco, Juan S.; Jones, Morris E.; Ilton, Eugene S.; Cerrato, José M.; Bargar, John R.; Fendorf, Scott

2014-10-01

Biogeochemical retention processes, including adsorption, reductive precipitation, and incorporation into host minerals, are important in contaminant transport, remediation, and geologic deposition of uranium. Recent work has shown that U can become incorporated into iron (hydr)oxide minerals, with a key pathway arising from Fe(II)-induced transformation of ferrihydrite, (Fe(OH)3·nH2O) to goethite (α-FeO(OH)); this is a possible U retention mechanism in soils and sediments. Several key questions, however, remain unanswered regarding U incorporation into iron (hydr)oxides and this pathway's contribution to U retention, including: (i) the competitiveness of U incorporation versus reduction to U(IV) and subsequent precipitation of UO2; (ii) the oxidation state of incorporated U; (iii) the effects of uranyl aqueous speciation on U incorporation; and, (iv) the mechanism of U incorporation. Here we use a series of batch reactions conducted at pH ∼7, [U(VI)] from 1 to 170 μM, [Fe(II)] from 0 to 3 mM, and [Ca] at 0 or 4 mM coupled with spectroscopic examination of reaction products of Fe(II)-induced ferrihydrite transformation to address these outstanding questions. Uranium retention pathways were identified and quantified using extended X-ray absorption fine structure (EXAFS) spectroscopy, X-ray powder diffraction, X-ray photoelectron spectroscopy, and transmission electron microscopy. Analysis of EXAFS spectra showed that 14-89% of total U was incorporated into goethite, upon reaction with Fe(II) and ferrihydrite. Uranium incorporation was a particularly dominant retention pathway at U concentrations ⩽50 μM when either uranyl-carbonato or calcium-uranyl-carbonato complexes were dominant, accounting for 64-89% of total U. With increasing U(VI) and Fe(II) concentrations, U(VI) reduction to U(IV) became more prevalent, but U incorporation remained a functioning retention pathway. These findings highlight the potential importance of U(V) incorporation within iron

Fluid dynamics applications of the Illiac IV computer

Science.gov (United States)

Maccormack, R. W.; Stevens, K. G., Jr.

1976-01-01

The Illiac IV is a parallel-structure computer with computing power an order of magnitude greater than that of conventional computers. It can be used for experimental tasks in fluid dynamics which can be simulated more economically, for simulating flows that cannot be studied by experiment, and for combining computer and experimental simulations. The architecture of Illiac IV is described, and the use of its parallel operation is demonstrated on the example of its solution of the one-dimensional wave equation. For fluid dynamics problems, a special FORTRAN-like vector programming language was devised, called CFD language. Two applications are described in detail: (1) the determination of the flowfield around the space shuttle, and (2) the computation of transonic turbulent separated flow past a thick biconvex airfoil.

THE LEO IV DWARF SPHEROIDAL GALAXY: COLOR-MAGNITUDE DIAGRAM AND PULSATING STARS

International Nuclear Information System (INIS)

Moretti, Maria Ida; Dall'Ora, Massimo; Ripepi, Vincenzo

2009-01-01

We present the first V, B - V color-magnitude diagram of the Leo IV dwarf spheroidal galaxy, a faint Milky Way satellite recently discovered by the Sloan Digital Sky Survey. We have obtained B, V time-series photometry reaching about half a magnitude below the Leo IV turnoff, which we detect at V = 24.7 mag, and have performed the first study of the variable star population. We have identified three RR Lyrae stars (all fundamental-mode pulsators, RRab) and one SX Phoenicis variable in the galaxy. In the period-amplitude diagram the Leo IV RR Lyrae stars are located close to the loci of Oosterhoff type I systems and the evolved fundamental-mode RR Lyrae stars in the Galactic globular cluster M3. However, their mean pulsation period, (Pab) = 0.655 days, would suggest an Oosterhoff type II classification for this galaxy. The RR Lyrae stars trace very well the galaxy's horizontal branch, setting its average magnitude at (V RR ) = 21.48 ± 0.03 mag (standard deviation of the mean). This leads to a distance modulus of μ 0 = 20.94 ± 0.07 mag, corresponding to a distance of 154 ± 5 kpc, by adopting for the Leo IV dSph a reddening E(B - V) = 0.04 ± 0.01 mag and a metallicity of [Fe/H] = -2.31 ± 0.10.

Operating experience and maintenance at the TRIGA Mark II LENA reactor

International Nuclear Information System (INIS)

Cingoli, F.; Altieri, S.; Lana, F.; Rosti, G.; Alloni, L.; Meloni, S.

1988-01-01

The last two years at the Trigs Mark II LENA plant were characterized by the running of the n-n-bar oscillation NADIR experiment. Consequently reactor operation was positively affected and the running hours rose again above 1000 hours per year. The LENA team was also deeply involved in the procedures for the renewal of the reactor operation license. The new requirements set by the Nuclear Energy Licensing Authority (ENEA for Italy) most of which concerning radiation protection and environmental impact, have been already fulfilled. In some cases the installation of new apparatus is underway

Nonoperative management for patients with grade IV blunt hepatic trauma

Directory of Open Access Journals (Sweden)

Zago Thiago

2012-08-01

Full Text Available Abstract Introduction The treatment of complex liver injuries remains a challenge. Nonoperative treatment for such injuries is increasingly being adopted as the initial management strategy. We reviewed our experience, at a University teaching hospital, in the nonoperative management of grade IV liver injuries with the intent to evaluate failure rates; need for angioembolization and blood transfusions; and in-hospital mortality and complications. Methods This is a retrospective analysis conducted at a single large trauma centre in Brazil. All consecutive, hemodynamically stable, blunt trauma patients with grade IV hepatic injury, between 1996 and 2011, were analyzed. Demographics and baseline characteristics were recorded. Failure of nonoperative management was defined by the need for surgical intervention. Need for angioembolization and transfusions, in-hospital death, and complications were also assessed Results Eighteen patients with grade IV hepatic injury treated nonoperatively during the study period were included. The nonoperative treatment failed in only one patient (5.5% who had refractory abdominal pain. However, no missed injuries and/or worsening of bleeding were observed during the operation. None of the patients died nor need angioembolization. No complications directly related to the liver were observed. Unrelated complications to the liver occurred in three patients (16.7%; one patient developed a tracheal stenosis (secondary to tracheal intubation; one had pleural effusion; and one developed an abscess in the pleural cavity. The hospital length of stay was on average 11.56 days. Conclusions In our experience, nonoperative management of grade IV liver injury for stable blunt trauma patients is associated with high success rates without significant complications.

Nonoperative management for patients with grade IV blunt hepatic trauma.

Science.gov (United States)

Zago, Thiago Messias; Tavares Pereira, Bruno Monteiro; Araujo Calderan, Thiago Rodrigues; Godinho, Mauricio; Nascimento, Bartolomeu; Fraga, Gustavo Pereira

2012-08-22

The treatment of complex liver injuries remains a challenge. Nonoperative treatment for such injuries is increasingly being adopted as the initial management strategy. We reviewed our experience, at a University teaching hospital, in the nonoperative management of grade IV liver injuries with the intent to evaluate failure rates; need for angioembolization and blood transfusions; and in-hospital mortality and complications. This is a retrospective analysis conducted at a single large trauma centre in Brazil. All consecutive, hemodynamically stable, blunt trauma patients with grade IV hepatic injury, between 1996 and 2011, were analyzed. Demographics and baseline characteristics were recorded. Failure of nonoperative management was defined by the need for surgical intervention. Need for angioembolization and transfusions, in-hospital death, and complications were also assessed Eighteen patients with grade IV hepatic injury treated nonoperatively during the study period were included. The nonoperative treatment failed in only one patient (5.5%) who had refractory abdominal pain. However, no missed injuries and/or worsening of bleeding were observed during the operation. None of the patients died nor need angioembolization. No complications directly related to the liver were observed. Unrelated complications to the liver occurred in three patients (16.7%); one patient developed a tracheal stenosis (secondary to tracheal intubation); one had pleural effusion; and one developed an abscess in the pleural cavity. The hospital length of stay was on average 11.56 days. In our experience, nonoperative management of grade IV liver injury for stable blunt trauma patients is associated with high success rates without significant complications.

Octacyanoniobate(IV)-based molecular magnets revealing 3D long-range order

International Nuclear Information System (INIS)

Pelka, R; Balanda, M; Pinkowicz, D; Drath, O; Nitek, W; Sieklucka, B; Rams, M; Majcher, A

2011-01-01

Isostructural series of chemical formula {[M II (pirazol) 4 ] 2 [Nb IV (CN) 8 ]· 4H 2 O} n (M II = Mn (1), Fe (2), Co (3), Ni (4)) has been obtained by the self-assembly technique. Its unique crystallographic structure consists in the formation of a 3D extended network of magnetic centers braced by geometrically identical cyanido bridges. Magnetic measurements reveal the transitions to the 3D order at temperatures 23.7, 8.3, 5.9, 13.4 K for 1, 2, 3, and 4, respectively. The character of order is demonstrated to be ferrimagnetic for 1 and 2 and ferromagnetic for 3 and 4. The mean-field approach is used to determine the corresponding exchange coupling constants. The observed interactions are discussed within the magnetic orbital model.

Neutrino Oscillation Experiments with J-PARC: T2K, T2K-II and Hyper-Kamiokande

CERN Multimedia

CERN. Geneva

2016-01-01

The T2K experiment started the operation in 2010, and advances neutrino physics with the discovery of electron neutrino appearance in the muon neutrino beam and precision measurements of neutrino oscillation parameters. In 2016, the measurements of anti-neutrino oscillation directly constrain CP violation in neutrino oscillation. In this colloquium, we introduce many physics results from T2K including the most recent one of the CP violation. By utilizing the J-PARC neutrino beam, the upgrade of the T2K experiment (naming T2K-II) is planned and Hyper-Kamiokande is proposed to explore neutrino physics further. In T2K-II, the beam power of J-PARC will be upgraded to 1.3 MW around 2020. Hyper-Kamiokande is the larger Water Cherenkov detector of 520 k...

A structurally characterized organometallic plutonium(IV) complex

Energy Technology Data Exchange (ETDEWEB)

Apostolidis, Christos; Walter, Olaf [European Commission, Joint Research Centre, Directorate G - Nuclear Safety and Security, Karlsruhe (Germany); Vogt, Jochen; Liebing, Phil; Edelmann, Frank T. [Chemisches Institut, Otto-von-Guericke-Universitaet Magdeburg (Germany); Maron, Laurent [Laboratoire de Physique et Chimie des Nanoobjets (LPCNO), Universite de Toulouse/INSA/CNRS (UMR5215), Toulouse (France)

2017-04-24

The blood-red plutonocene complex Pu(1,3-COT'')(1,4-COT'') (4; COT''=η{sup 8}-bis(trimethylsilyl)cyclooctatetraenyl) has been synthesized by oxidation of the anionic sandwich complex Li[Pu(1,4-COT''){sub 2}] (3) with anhydrous cobalt(II) chloride. The first crystal structure determination of an organoplutonium(IV) complex revealed an asymmetric sandwich structure for 4 where one COT'' ring is 1,3-substituted while the other retains the original 1,4-substitution pattern. The electronic structure of 4 has been elucidated by a computational study, revealing a probable cause for the unexpected silyl group migration. (copyright 2017 Wiley-VCH Verlag GmbH and Co. KGaA, Weinheim)

Beam dynamics of the Neutralized Drift Compression Experiment-II (NDCX-II),a novel pulse-compressing ion accelerator

International Nuclear Information System (INIS)

Friedman, A.; Barnard, J.J.; Cohen, R.H.; Grote, D.P.; Lund, S.M.; Sharp, W.M.; Faltens, A.; Henestroza, E.; Jung, J.-Y.; Kwan, J.W.; Lee, E.P.; Leitner, M.A.; Logan, B.G.; Vay, J.-L.; Waldron, W.L.; Davidson, R.C.; Dorf, M.; Gilson, E.P.; Kaganovich, I.D.

2009-01-01

Intense beams of heavy ions are well suited for heating matter to regimes of emerging interest. A new facility, NDCX-II, will enable studies of warm dense matter at ∼1 eV and near-solid density, and of heavy-ion inertial fusion target physics relevant to electric power production. For these applications the beam must deposit its energy rapidly, before the target can expand significantly. To form such pulses, ion beams are temporally compressed in neutralizing plasma; current amplification factors of ∼50-100 are routinely obtained on the Neutralized Drift Compression Experiment (NDCX) at LBNL. In the NDCX-II physics design, an initial non-neutralized compression renders the pulse short enough that existing high-voltage pulsed power can be employed. This compression is first halted and then reversed by the beam's longitudinal space-charge field. Downstream induction cells provide acceleration and impose the head-to-tail velocity gradient that leads to the final neutralized compression onto the target. This paper describes the discrete-particle simulation models (1-D, 2-D, and 3-D) employed and the space-charge-dominated beam dynamics being realized.

Complexation of the An(IV) by NTA; Complexation des An(IV) par le NTA

Energy Technology Data Exchange (ETDEWEB)

Bonin, L. [Paris-11 Univ., 91 - Orsay (France)]|[CEA Valrho, Lab. de Chimie des Actinides (LCA), 30 - Marcoule (France)

2006-07-01

In the framework of the Nuclear and Environmental Toxicology program, developed in France, it has been decided to take again the studies concerning the actinides decorporation. A similar study of the neptunium complexation by the citrate ions has been carried out on the complexation of Np(IV) with the nitrilotriacetic acid (NTA). The NTA can be considered as a model molecule of the de-corporating molecules (amino-carboxy- ligand). The results of the spectrophotometric measurements being encouraging, the behaviour of several actinides at the same oxidation state (+IV) (Th(IV), U(IV), Np(IV), and Pu(IV)) has been determined. The experimental results are presented. In order to determine the structure of the complexes of stoichiometry 1:2 An(IV)-(NTA){sub 2} in solution, quantic chemistry calculations and EXAFS measurements have been carried out in parallel. These studies confirm the presence of An(IV)-nitrogen bonds whose length decreases from thorium to plutonium and indicate the presence of a water molecule bound to the thorium and the uranium (coordination number 8 for Np/Pu, 9 for Th/U). The evolution of the complexation constants determined in this study in terms of 1/r (r ionic radius of the cation taking into account its coordination number 8 or 9) confirms the change of the coordination number between Th/U and Np/Pu. (O.M.)

Technical data summary: Uranium(IV) production using a large scale electrochemical cell

International Nuclear Information System (INIS)

Hsu, T.C.

1984-05-01

This Technical Data Summary outlines an electrochemical process to produce U(IV), in the form of uranous nitrate, from U(VI), as uranyl nitrate. U(IV) with hydrazine could then be used as an alternative plutonium reductant to substantially reduce the waste volume from the Purex solvent extraction process. This TDS is divided into three parts. The first part (Chapters I to IV) generally describes the electrochemical production of U(IV). The second part (Chapters V to VII) describes a pilot scale U(IV) production facility that was constructed and operated at an engineering semiworks area of SRP, referred to as TNX. The lst part (Chapter VIII) describes a preliminary design for a full-scale facility that would meet the projected need for U(IV) as a reductant in SRP's separations processes. The preliminary design was described in a Basic Data Summary for the U(IV) production facility, and a Venture Guidance Appraisal (VGA) was prepared from the Basic Data Summary. The VGA for the U(IV) process showed that because of the large capital investment required, this approach to waste reduction was not economically competitive with another alternative that required only modifying the ongoing Purex process at no additional capital cost. However, implementing he U(IV) process as part of an overall canyon renovation, presently scheduled for the 1990's, may be economically attractive. The purpose of this TDS is therefore to bring together the information and experience obtained thus far in the U(IV) program so that a useful body of information will be available to support any future development of this process

Ca II H and K emission from late-type stars

International Nuclear Information System (INIS)

Middlekoop, F.

1982-01-01

This thesis is based on a study of the Ca II H and K emission features of late main-sequence stars. In Chapter II it is shown that rotation periods can be determined from a modulation in the Ca II H and K signal for many stars in a broad range of spectral types. In Chapter III it is shown that a clear correlation exists between Ca II H and K emission and rotational velocity in active main-sequence stars. There is an indication for a (probably colour-dependent) critical velocity at which the Ca II H and K emission suddenly drops. Chapter IV discusses the dependence of Ca II H and K emission on the rotation rate for evolved stars. (Auth./C.F.)

Closure of the patent ductus arteriosus with the Amplatzer Duct Occluder II: a clinical experience.

Science.gov (United States)

Karagöz, Tevfik; Akin, Alper; Ertuğrul, Ilker; Aykan, Hayrettin Hakan; Alehan, Dursun; Ozer, Sema; Ozkutlu, Süheyla

2012-12-01

The aim of our study was to share our clinical experience on cases with patent ductus arteriosus treated with the Amplatzer Duct Occluder II. Between 2008 and 2012, 26 of 31 patients with patent ductus arteriosus underwent successful transcatheter closure of patent ductus arteriosus using the Amplatzer Duct Occluder II. Mean age was 3.3 years and mean weight was 15.7 kilograms. The presence of a residual shunt, left pulmonary artery or aortic obstruction was explored by administering contrast material during the procedure. The patients were discharged 24 hours after the procedure. The procedure was successful in 26 of 31 patients and failed in five patients. According to the Krichenko classification, 26 patients had type A, one patient had type B and 4 patients had type C ductus. The mean narrowest ductus diameter was 3.2 mm and the mean ductus length was 6.7 mm. Complete angiographic occlusion occurred immediately after the procedure in 22 out of 26 patients in whom the ductus was closed successfully with the Amplatzer Duct Occluder II. Complete occlusion was achieved in the remaining patients with residual shunt one month after the procedure. The procedure was preceded by closure with an Amplatzer Duct Occluder I in two patients and an Amplatzer Vascular Plug I in one patient. Amplatzer Duct Occluder II is highly effective in transcatheter closure of patent ductus arteriosus. We think that an alternative closure device and alternative techniques can be attempted in patients with type C ductus. The success rate could increase with accumulating experience.

Comparison of gray-scale contrast-enhanced ultrasonography with contrast-enhanced computed tomography in different grading of blunt hepatic and splenic trauma: an animal experiment.

Science.gov (United States)

Tang, Jie; Li, Wenxiu; Lv, Faqin; Zhang, Huiqin; Zhang, Lihai; Wang, Yuexiang; Li, Junlai; Yang, Li

2009-04-01

To compare the diagnostic value of contrast-enhanced ultrasonography (CEUS) with contrast-enhanced computed tomography (CECT) for the detection of different grading of solid organ injuries in blunt abdominal trauma in animals. A self-made miniature tools were used as models to simulate a blunt hepatic or splenic trauma in 16 and 14 anesthetized dogs, respectively. Baseline ultrasound, CEUS and CECT were used to detect traumatic injuries of livers and spleens. The degree of injuries was determined by CEUS according to the American Association for the Surgery of Trauma (AAST) scale and the results compared with injury scale based on CECT evaluation. CEUS showed 22 hepatic injury sites in 16 animals and 17 splenic injury sites in other 14 animals. According to AAST scale, 2 grade I, 4 grade II, 3 grade III, 5 grade IV and 2 grade V hepatic lesions were present in 16 animals; 2 grade I, 4 grade II, 6 grade III and 2 grade IV splenic lesions in 14 animals. On CECT scan, 21 hepatic and 17 splenic injuries were demonstrated. According to Becker CT scaling for hepatic injury, 1 grade I, 2 grade II, 4 grade III, 5 grade IV and 2 grade V hepatic injuries were present. On the basis of Buntain spleen scaling, 2 grade I, 5 grade II, 5 grade III, 2 grade IV splenic injuries were showed. After Spearman rank correlation analysis, the agreement of CEUS with CECT on the degree of hepatic and splenic injury is 93.3% and 92.9%, respectively. CT is currently considered as the reference method for grading blunt abdominal trauma, according to experiment results, CEUS grading showed high levels of concordance with CECT. CEUS can accurately determine the degree of injury and will play an important role in clinical application.

Post-test simulation and analysis of the second full scale CHAN 28-element experiment (validations of CHAN-II (MOD 6) against experiments)

Energy Technology Data Exchange (ETDEWEB)

Bayoumi, M H; Muir, W C [Ontario Hydro, Toronto, ON (Canada)

1996-12-31

An experimental program, the CHAN Thermal Chemical Experimental Program, has been setup at WNRE under COG/CANDEV to assess and verify the physical and mathematical models of the CHAN codes. The program has been progressing from studying separate effects in single-element experiments to a full integrated mode in a CANDU 28-element bundle geometry. The CHAN-II series codes are used in the licensing analysis of CANDU reactors. The basic code provides an efficient tool to predict the thermal response of a fuel channel during postulated loss-of-coolant accidents (LOCA) with and without a loss of emergency coolant injection (LOECI) in which the transport of heat by convection is greatly reduced. The code models the progression of the event including fuel channel geometry deformation due to severe overheating. It is the main objective of this paper to discuss further verification of the CHAN-II (MOD 6) computer code against the second full scale 28-element experiment performed at WNRE under COG/CANDEV, designed to represent a Pickering type bundle geometry. The main models and assumptions used in the code will be briefly described. The objective of the experiments is to provide data for the assessment of the physical and mathematical models of the CHAN codes and produce data for code verification under integrated conditions with significant hydrogen production and flow rates similar to the LOCA/LOECI scenario. The issue of whether the Zr/steam reaction is sustainable in a full bundle geometry at elevated temperatures is also examined. A comparison between the predictions of CHAN-II (MOD 6) and the experimental results is discussed. (author).12 refs., 17 figs.

Post-test simulation and analysis of the second full scale CHAN 28-element experiment (validations of CHAN-II (MOD 6) against experiments)

International Nuclear Information System (INIS)

Bayoumi, M.H.; Muir, W.C.

1995-01-01

An experimental program, the CHAN Thermal Chemical Experimental Program, has been setup at WNRE under COG/CANDEV to assess and verify the physical and mathematical models of the CHAN codes. The program has been progressing from studying separate effects in single-element experiments to a full integrated mode in a CANDU 28-element bundle geometry. The CHAN-II series codes are used in the licensing analysis of CANDU reactors. The basic code provides an efficient tool to predict the thermal response of a fuel channel during postulated loss-of-coolant accidents (LOCA) with and without a loss of emergency coolant injection (LOECI) in which the transport of heat by convection is greatly reduced. The code models the progression of the event including fuel channel geometry deformation due to severe overheating. It is the main objective of this paper to discuss further verification of the CHAN-II (MOD 6) computer code against the second full scale 28-element experiment performed at WNRE under COG/CANDEV, designed to represent a Pickering type bundle geometry. The main models and assumptions used in the code will be briefly described. The objective of the experiments is to provide data for the assessment of the physical and mathematical models of the CHAN codes and produce data for code verification under integrated conditions with significant hydrogen production and flow rates similar to the LOCA/LOECI scenario. The issue of whether the Zr/steam reaction is sustainable in a full bundle geometry at elevated temperatures is also examined. A comparison between the predictions of CHAN-II (MOD 6) and the experimental results is discussed. (author).12 refs., 17 figs

Plasma opening switch development for the Particle Beam Fusion Accelerator II (PBFA II)

International Nuclear Information System (INIS)

Stinnett, R.W.; McDaniel, D.H.; Rochau, G.E.

1987-01-01

The authors conducted plasma opening switch (POS) experiments on Sandia National Laboratories' new Particle Beam Fusin Accelerator II (PBFA II) (12 MV, 100 TW, 50 ns), on the Supermite accelerator (2 MV, 2 TW, 50 ns) and on the Naval Research Laboratory's Gamble II accelerator (1.8 MV, 1.6 TW, 70 ns). The POS systems on the PBFA II and Supermite accelerators use a newly developed flashboard plasma source to provide the plasma necessary to conduct the large (> 1 MA) currents produced byu these accelerators. In the Supermite experiments, the plasma opening switch conducted currents up to 1 MA before opening in less than 10 ns into an electron beam load. These experiments achieved significant voltage gain relative to the voltage across a matched load. In experiments on Gamble II, power gains of up to 1.7 were achieved using a POS in a strongly coaxial geometry (r/sub outer//r/sub inner/ = 2) with a large magnetic field at the cathode. The POS system on PBFA II is unique because of its size and voltage. This POS system is designed to conduct over 6 MA before opening. In present experiments it has conducted currents of 4-5 MA for over 50 ns

Human antibody recognition of antigenic site IV on Pneumovirus fusion proteins.

Science.gov (United States)

Mousa, Jarrod J; Binshtein, Elad; Human, Stacey; Fong, Rachel H; Alvarado, Gabriela; Doranz, Benjamin J; Moore, Martin L; Ohi, Melanie D; Crowe, James E

2018-02-01

Respiratory syncytial virus (RSV) is a major human pathogen that infects the majority of children by two years of age. The RSV fusion (F) protein is a primary target of human antibodies, and it has several antigenic regions capable of inducing neutralizing antibodies. Antigenic site IV is preserved in both the pre-fusion and post-fusion conformations of RSV F. Antibodies to antigenic site IV have been described that bind and neutralize both RSV and human metapneumovirus (hMPV). To explore the diversity of binding modes at antigenic site IV, we generated a panel of four new human monoclonal antibodies (mAbs) and competition-binding suggested the mAbs bind at antigenic site IV. Mutagenesis experiments revealed that binding and neutralization of two mAbs (3M3 and 6F18) depended on arginine (R) residue R429. We discovered two R429-independent mAbs (17E10 and 2N6) at this site that neutralized an RSV R429A mutant strain, and one of these mAbs (17E10) neutralized both RSV and hMPV. To determine the mechanism of cross-reactivity, we performed competition-binding, recombinant protein mutagenesis, peptide binding, and electron microscopy experiments. It was determined that the human cross-reactive mAb 17E10 binds to RSV F with a binding pose similar to 101F, which may be indicative of cross-reactivity with hMPV F. The data presented provide new concepts in RSV immune recognition and vaccine design, as we describe the novel idea that binding pose may influence mAb cross-reactivity between RSV and hMPV. Characterization of the site IV epitope bound by human antibodies may inform the design of a pan-Pneumovirus vaccine.

Surface Mn(II) oxidation actuated by a multicopper oxidase in a soil bacterium leads to the formation of manganese oxide minerals.

Science.gov (United States)

Zhang, Zhen; Zhang, Zhongming; Chen, Hong; Liu, Jin; Liu, Chang; Ni, Hong; Zhao, Changsong; Ali, Muhammad; Liu, Fan; Li, Lin

2015-06-03

In this manuscript, we report that a bacterial multicopper oxidase (MCO266) catalyzes Mn(II) oxidation on the cell surface, resulting in the surface deposition of Mn(III) and Mn(IV) oxides and the gradual formation of bulky oxide aggregates. These aggregates serve as nucleation centers for the formation of Mn oxide micronodules and Mn-rich sediments. A soil-borne Escherichia coli with high Mn(II)-oxidizing activity formed Mn(III)/Mn(IV) oxide deposit layers and aggregates under laboratory culture conditions. We engineered MCO266 onto the cell surfaces of both an activity-negative recipient and wild-type strains. The results confirmed that MCO266 governs Mn(II) oxidation and initiates the formation of deposits and aggregates. By contrast, a cell-free substrate, heat-killed strains, and intracellularly expressed or purified MCO266 failed to catalyze Mn(II) oxidation. However, purified MCO266 exhibited Mn(II)-oxidizing activity when combined with cell outer membrane component (COMC) fractions in vitro. We demonstrated that Mn(II) oxidation and aggregate formation occurred through an oxygen-dependent biotic transformation process that requires a certain minimum Mn(II) concentration. We propose an approximate electron transfer pathway in which MCO266 transfers only one electron to convert Mn(II) to Mn(III) and then cooperates with other COMC electron transporters to transfer the other electron required to oxidize Mn(III) to Mn(IV).

Experience in the chemistry field from the operating cycle of Grohnde and Philippsburg II nuclear power stations

International Nuclear Information System (INIS)

Jacobi, G.; Ruehle, W.

1987-01-01

Experience from the primary section of the plants in relation to the activity pattern of corrosion products, indicates primarily that cobalt-free materials have been used throughout in Philippsburg II nuclear power station, which was no longer economically possible at Grohnde because of the advanced stages of manufacture and installation. Consequently, the activity concentration for Co-60 in Philippsburg was lower from the outset than at a comparable time at Grohnde. The second part of the paper discusses experience from the secondary section of the plants, based on the AVT (all volatile treatment) method of operation and its effect on the deposits in the steam generators. The chemical control is described and a comparison is made between the sampling points at Grohnde and Philippsburg II. (orig.) [de

Der II. Hauptsatz der Wärmelehre

Science.gov (United States)

Heintze, Joachim

Wir haben in (4.44) den II. Hauptsatz als empirische Tatsache folgendermaßen formuliert: (i) Wärmeenergie geht von selbst nur von einem wärmeren Körper auf einen kälteren über, niemals in der umgekehrten Richtung. Nun werden wir beweisen, dass sich aus diesem Prinzip folgende äquivalente Formulierungen für den II. Hauptsatz ableiten lassen: (ii) Es ist unmöglich, ein Perpetuum mobile zweiter Art zu bauen, d. h. eine Maschine, die fortlaufend Wärmeenergie vollständig in mechanische Arbeit umsetzen kann. Eine Wärmekraftmaschine, die einen Kreisprozess mit der höchsten Temperatur Tw und der niedrigsten Temperatur Tk durchläuft, hat höchstens den Carnotschen Wirkungsgrad c = (Tw - Tk)/Tw. Wenn in der Maschine nur reversible Prozesse ablaufen, die gesamte Wärmezufuhr bei der Temperatur Tw erfolgt und ausschließlich bei der Temperatur Tw gekühlt wird, ist ihr Wirkungsgrad = C. Es gibt keine Wärmekraftmaschine, die eine bessere Ausnutzung der Wärmeenergie ermöglicht. (iv) In jedem thermodynamischen System existiert die Zustandsgröße Entropie, definiert durch ihr Differential dS = (dQrev)/T . Entropie kann erzeugt, aber nicht vernichtet werden. Bei Zustandsänderungen, die in einem abgeschlossenen System ablaufen, nimmt die Entropie entweder zu (irreversible Prozesse), oder sie bleibt konstant (reversible Prozesse). Im Anschluss an (iii) werden wir zur Definition der thermodynamischen Temperatur und bei der Diskussion von (iv) zu einem tieferen Verständnis der Entropie gelangen. Es zeigt sich, dass die Entropie das eigentliche Bindeglied zwischen Mechanik und Wärmelehre darstellt. Am Ende des Kapitels werden wir einige Anwendungen des II. Hauptsatzes betrachten.

An FPGA-based trigger for the phase II of the MEG experiment

Energy Technology Data Exchange (ETDEWEB)

Baldini, A. [Istituto Nazionale di Fisica Nucleare, Pisa (Italy); Bemporad, C.; Cei, F. [Istituto Nazionale di Fisica Nucleare, Pisa (Italy); Dipartimento di Fisica, Università di Pisa (Italy); Galli, L.; Grassi, M.; Morsani, F. [Istituto Nazionale di Fisica Nucleare, Pisa (Italy); Nicolò, D., E-mail: donato.nicolo@pi.infn.it [Istituto Nazionale di Fisica Nucleare, Pisa (Italy); Dipartimento di Fisica, Università di Pisa (Italy); Ritt, S. [Paul Scherrer Institut, Villigen AG (Switzerland); Venturini, M. [Istituto Nazionale di Fisica Nucleare, Pisa (Italy); Scuola Normale Superiore, Pisa (Italy)

2016-07-11

For the phase II of MEG, we are going to develop a combined trigger and DAQ system. Here we focus on the former side, which operates an on-line reconstruction of detector signals and event selection within 450 μs from event occurrence. Trigger concentrator boards (TCB) are under development to gather data from different crates, each connected to a set of detector channels, to accomplish higher-level algorithms to issue a trigger in the case of a candidate signal event. We describe the major features of the new system, in comparison with phase I, as well as its performances in terms of selection efficiency and background rejection. - Highlights: • A new, two-level trigger scheme for the phase-II of the MEG experiment is presented. • Improvements with respect to phase-I are underlined. • The role of detector upgrades and the use of a new generation of FPGA as well are emphasized.

Methicillin-resistant Staphylococcus aureus in Rio de Janeiro hospitals: dissemination of the USA400/ST1 and USA800/ST5 SCCmec type IV and USA100/ST5 SCCmec type II lineages in a public institution and polyclonal presence in a private one.

Science.gov (United States)

Caboclo, Roberta Mello Ferreira; Cavalcante, Fernanda Sampaio; Iorio, Natalia Lopes Pontes; Schuenck, Ricardo Pinto; Olendzki, André Nogueira; Felix, Maria José; Chamon, Raiane Cardoso; dos Santos, Kátia Regina Netto

2013-03-01