Environmental policy in the 9th German Bundestag and the Bundesrat (1980-1983)

International Nuclear Information System (INIS)

1983-01-01

This presentation of environmental policy constitutes the continuation of copies No. 49 and No. 72 of the 'Materialien' [Materials] (Environmental policy in the 7th German Bundestag or environmental policy in the 8. German Bundestag and in the Bundesrat, resp. - 1976 to 1980). References to factual terms espec. indications of speech references, apply to the register annexed to 'Verhandlungen des Deutschen Bundestages und des Bundesrates' (Deliberations of the German Bundestag and the Bundesrat) for the 9th period of office on which the 'Materialie' is based. Among other things, the 'Materialie' comprises: General fundamentals and primaples, aspects of structural policy, scientific and technical/technological fundamentals, organizational fundamentals, international and intergovernmental co-operation, air-borne emission abatement, waste management, chemical substances released to environment, nuclear energy. (orig./HP) [de

9th International Conference on Robotics, Vision, Signal Processing & Power Applications

CERN Document Server

Iqbal, Shahid; Teoh, Soo; Mustaffa, Mohd

2017-01-01

 The proceeding is a collection of research papers presented, at the 9th International Conference on Robotics, Vision, Signal Processing & Power Applications (ROVISP 2016), by researchers, scientists, engineers, academicians as well as industrial professionals from all around the globe to present their research results and development activities for oral or poster presentations. The topics of interest are as follows but are not limited to:   • Robotics, Control, Mechatronics and Automation • Vision, Image, and Signal Processing • Artificial Intelligence and Computer Applications • Electronic Design and Applications • Telecommunication Systems and Applications • Power System and Industrial Applications • Engineering Education.

Suicidal ideation among students of the 7th, 8th, and 9th grades in the State of Lara, Venezuela: the Global School Health Survey.

Science.gov (United States)

Granero, Ricardo; Poni, Esteban; Poni, Carolin

2008-12-01

Suicidal behavior among adolescents is not a well-explored public health problem. Health policy decision-making on suicidal behavior needs reliable information on the prevalence of suicidal ideation (SI) and its associated risk factors to produce health promotion and prevention programs. The Global School Health Survey is a self-administered survey done on a random probabilistic sample among students of the 7th, 8th, and 9th grades in the Lara State, Venezuela, school period 2003 to 2004. Point prevalence of SI and associated factors were included and the odds (OR) of having SI was calculated given selected factors. Two-thousand seventy (2070) respondents, of which 13.5 % reported having SI in the last 12 months, and in females more than males (14.6% vs. 11.7%). The OR for SI, according to an associated risk factor, were among (a) females: age > or = 14 years (2.2), worries (3.42), loneliness (8.8), ever had sexual intercourse (5.58), alcohol (8.43) and (b) males: having only one or non close friends (3.69), alcohol (12.36), ever had sexual intercourse (2.73). Behavioral risk factors are relatively new in the field of surveillance systems; therefore, results on SI should be cautiously taken into consideration and a wide discussion should be encouraged as we learn how to best use the results for health promotion and disease prevention.

Foxo1 and Foxp1 play opposing roles in regulating the differentiation and antitumor activity of TH9 cells programmed by IL-7

Science.gov (United States)

Bi, Enguang; Ma, Xingzhe; Lu, Yong; Yang, Maojie; Wang, Qiang; Xue, Gang; Qian, Jianfei; Wang, Siqing; Yi, Qing

2018-01-01

Tumor-specific CD4+ T helper 9 (TH9) cells, so-called because of their production of the cytokine interleukin-9 (IL-9), are a powerful effector T cell subset for cancer immunotherapy. We found that pretreatment of naïve CD4+ T cells with IL-7 further enhanced their differentiation into TH9 cells and augmented their antitumor activity. IL-7 markedly increased the abundance of the histone acetyltransferase p300 by activating the STAT5 and PI3K-AKT-mTOR signaling pathways and promoting the acetylation of histones at the Il9 promoter. As a result, the transcriptional regulator Foxo1 was dephosphorylated and translocated to the nucleus, bound to the Il9 promoter, and induced the production of IL-9 protein. In contrast, Foxp1, which bound to the Il9 promoter in naïve CD4+ T cells and inhibited Il9 expression, was outcompeted for binding to the Il9 promoter by Foxo1 and translocated to the cytoplasm. Furthermore, forced expression of Foxo1 or a deficiency in Foxp1 in CD4+ T cells markedly increased the production of IL-9, whereas a deficiency in Foxo1 inhibited the ability of IL-7 to enhance the differentiation and antitumor activity of TH9 cells. Thus, we identified the roles of Foxo1 as a positive regulator and Foxp1 as a negative regulator of TH9 cell differentiation and antitumor activity, which may provide potential targets for cancer immunotherapy. PMID:29018172

Sujet de droit et sujet d’intérêt : Montesquieu lu par Foucault

Directory of Open Access Journals (Sweden)

Céline Spector

2007-04-01

Full Text Available Dans les cours au Collège de France réunis dans Naissance de la biopolitique, Foucault soutient qu’une science économico-juridique est rigoureusement impossible. Or cette thèse radicale mérite discussion, à partir d’un auteur trop souvent ignoré des historiens de la genèse de l’économie politique. Montesquieu, à sa façon, contribue à la constitution de ce savoir économico-juridique, susceptible de penser ensemble sujet d’intérêt et sujet de droit. L’esprit de cette étude ne sera pas de critiquer Foucault en montrant que Montesquieu ne « rentre » pas dans l’opposition de ses paradigmes, mais plutôt de tenter de mesurer l’originalité d’une pensée qui conçoit des échanges entre propriété et liberté qui ont pour effet d’unifier rationalité économique et rationalité juridique.

Appel à manifestations d'intérêt

International Development Research Centre (IDRC) Digital Library (Canada)

gprudhomme

17 mars 2014 ... ... de santé, les soins de santé primaires, la santé des mères et des enfants et la ..... général des points ci-dessous à l'étape de la manifestation d'intérêt. ..... font désormais appel à des cliniciens autres que des médecins pour.

9th IFToMM International Conference on Rotor Dynamics

CERN Document Server

2015-01-01

This book presents the proceedings of the 9th IFToMM International Conference on Rotor Dynamics. This conference is a premier global event that brings together specialists from the university and industry sectors worldwide in order to promote the exchange of knowledge, ideas, and information on the latest developments and applied technologies in the dynamics of rotating machinery. The coverage is wide ranging, including, for example, new ideas and trends in various aspects of bearing technologies, issues in the analysis of blade dynamic behavior,  condition monitoring of different rotating machines, vibration control, electromechanical and fluid-structure interactions in rotating machinery, rotor dynamics of micro, nano, and cryogenic machines, and applications of rotor dynamics in transportation engineering. Since its inception 32 years ago, the IFToMM International Conference on Rotor Dynamics has become an irreplaceable point of reference for those working in the field, and this book reflects the high qua...

IntNetLncSim: an integrative network analysis method to infer human lncRNA functional similarity.

Science.gov (United States)

Cheng, Liang; Shi, Hongbo; Wang, Zhenzhen; Hu, Yang; Yang, Haixiu; Zhou, Chen; Sun, Jie; Zhou, Meng

2016-07-26

Increasing evidence indicated that long non-coding RNAs (lncRNAs) were involved in various biological processes and complex diseases by communicating with mRNAs/miRNAs each other. Exploiting interactions between lncRNAs and mRNA/miRNAs to lncRNA functional similarity (LFS) is an effective method to explore function of lncRNAs and predict novel lncRNA-disease associations. In this article, we proposed an integrative framework, IntNetLncSim, to infer LFS by modeling the information flow in an integrated network that comprises both lncRNA-related transcriptional and post-transcriptional information. The performance of IntNetLncSim was evaluated by investigating the relationship of LFS with the similarity of lncRNA-related mRNA sets (LmRSets) and miRNA sets (LmiRSets). As a result, LFS by IntNetLncSim was significant positively correlated with the LmRSet (Pearson correlation γ2=0.8424) and LmiRSet (Pearson correlation γ2=0.2601). Particularly, the performance of IntNetLncSim is superior to several previous methods. In the case of applying the LFS to identify novel lncRNA-disease relationships, we achieved an area under the ROC curve (0.7300) in experimentally verified lncRNA-disease associations based on leave-one-out cross-validation. Furthermore, highly-ranked lncRNA-disease associations confirmed by literature mining demonstrated the excellent performance of IntNetLncSim. Finally, a web-accessible system was provided for querying LFS and potential lncRNA-disease relationships: http://www.bio-bigdata.com/IntNetLncSim.

FOREWORD: 9th Curtin University of Technology Science and Engineering International Conference 2014 (CUTSE2014)

Science.gov (United States)

Chieng Chen, Vincent Lee

2015-04-01

A very warm welcome to all participants of the 9th Curtin University Technology, Science and Engineering (CUTSE) Conference 2014. This annual conference dates back to 2006 when the first Curtin University of Technology Science and Engineering (CUTSE) Conference was held in Curtin University, Miri Sarawak. CUTSE Conference was initially intended for Curtin's undergraduates such that they are able to experience the presentation of their work in a conference environment. As time passes and following the urge of knowledge dissemination, CUTSE Conference is hence open to public. This year the Department of Mechanical Engineering has been given the honour to organize the 9th CUTSE Conference. It has been a pleasure to watch CUTSE grow from strength to strength over the years. This year, our theme is "Discovering, Innovating and Engineering". We hope that it is in this spirit that CUTSE participants may align their respective work, such that we all aim for a greater and better implementation of "Discovering, Innovating and Engineering". The 9th CUTSE Conference 2014 is an excellent avenue for researchers, engineers, scientists, academicians, professionals from industry and students to share their research findings and initiate further collaborations in their respective fields. Parallel sessions in Mechanical, Electrical, Computer, Civil and Chemical engineering as well as the sciences will be hosted over a period of two days. Each year, the conference attracts participation from a number of countries in addition to Malaysia and Australia. In addition, student participants will get the opportunity to present their research projects and gain valuable feedback from industry professionals. This year the Conference will be organised by the Department of Mechanical Engineering of Curtin Sarawak's School of Engineering and Science in collaboration with The Institute of Engineers Malaysia, Miri Branch. On behalf of the organizing committee, I would like to thank this year

Multidisciplinary molecular diagnostics: the 9th European meeting on molecular diagnostics.

Science.gov (United States)

Loonen, Anne J M; Schuurman, Rob; van den Brule, Adriaan J C

2016-01-01

This report presents a summary of the 9th European Meeting on Molecular Diagnostics held in Noordwijk, The Netherlands, 14-16 October 2015. This 3-day conference covered many relevant topics in the field of molecular diagnostics in humans, including infectious disease, oncology, outbreak management, population-based cancer screening, standardization and quality control, chronic diseases and pharmacogenetics. Beyond these different areas, shared values are new technologies and novel technical and clinical applications. Approximately 450 participants, the majority coming from European countries, attended the meeting. Besides high quality scientific presentations, more than 35 diagnostic companies presented their latest innovations, altogether in an informal and inspiring scientific ambience.

The HUPO Brain Proteome project wish list--summary of the 9(th) HUPO BPP Workshop 9-10 January 2008, Barbados.

Science.gov (United States)

Hamacher, Michael; Eisenacher, Martin; Tribl, Florian; Stephan, Christian; Marcus, Katrin; Hardt, Tanja; Wiltfang, Jens; Martens, Lennart; Desiderio, Dominic; Gutstein, Howard; Park, Young Mok; Meyer, Helmut E

2008-06-01

The Human Brain Proteome Project (HUPO BPP) aims at advancing knowledge and the understanding of neurodiseases and aging with the purpose of identifying prognostic and diagnostic biomarkers, as well as to push new diagnostic approaches and medications. The participating groups meet in semi-annual workshops to discuss the progress, as well as the needs, within the field of proteomics. The 9(th) HUPO BPP workshop took place in Barbados from 9-10 January, 2008. Discussing the future HUPO BPP Roadmap, the attendees drafted the so called HUPO BPP wish list containing timelines, suggestions and missions. This wish list will be updated regularly and will serve as a guideline for the next phase.

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African Journals Online (AJOL)

SAM

plicates. Fish estigated. Tr had six rep ermined. Th hey were s the most e tein was e .... recommends the use of up to 20% sunflower in the diet of ... to improve the quality of feed. .... Trial 1 was run for a period of 120 days in a pond with a water.

Advance Organizers and Examining of their Usage in 9th Grade Chemistry Textbooks

OpenAIRE

Canan NAKİBOĞLU; Nihan KAŞMER; Cem GÜLTEKİN; Füsun DÖNMEZ

2010-01-01

An advance organizer is the tool that is presented prior to the material to be learned, and that helps learners to organize and interpret new incoming information. In this study, a concept map concerning the classification of advance organizer was developed. Then, 9th grade chemistry textbooks written according to both current (year 2007) and past (year 1996) high school chemistry curriculum were examined by taking into account the concept map prepared. Next, the findings of each textbook ana...

A VUV detection system for the direct photonic identification of the first excited isomeric state of "2"2"9Th

International Nuclear Information System (INIS)

Seiferle, B.; Von der Wense, L.; Thirolf, P.G.; Laatiaoui, M.

2016-01-01

With an expected energy of 7.6(5) eV, "2"2"9Th possesses the lowest excited nuclear state in the landscape of all presently known nuclei. The energy corresponds to a wavelength of about 160 nm and would conceptually allow for an optical laser excitation of a nuclear transition. We report on a VUV optical detection system that was designed for the direct detection of the isomeric ground-state transition of "2"2"9Th. "2"2"9"("m") Th ions originating from a "2"3"3U α-recoil source are collected on a micro electrode that is placed in the focus of an annular parabolic mirror. The latter is used to parallelize the UV fluorescence that may emerge from the isomeric ground-state transition of "2"2"9Th. The parallelized light is then focused by a second annular parabolic mirror onto a CsI-coated position-sensitive MCP detector behind the mirror exit. To achieve a high signal-to-background ratio, a small spot size on the MCP detector needs to be achieved. Besides extensive ray-tracing simulations of the optical setup, we present a procedure for its alignment, as well as test measurements using a D_2 lamp, where a focal-spot size of ∼100 μm has been achieved. Assuming a purely photonic decay, a signal-to-background ratio of ∼7000:1 could be achieved. (authors)

Meeting the Editors at the 9th Iberoamerican Academy of Management Conference

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Fernando Antonio Ribeiro Serra

2016-06-01

Full Text Available The following Editorial Comment presents a summary of the main ideas and suggestions presented at the “Meeting with the Editors” at the 9th Iberoamerican Academy of Management (IAM Conference, in Santiago (Chile. The meeting was conducted by three editors: Jonathan Doh from the Journal of World Business, Martin Larraza from Management Research and Herman Aguinis, President of the Iberoamerican Academy of Management and former editor of Organizational Research Methods. The conference took place from 3rd to 5th December 2015, and was hosted by Universidad Del Desarrollo. This editorial does not change the focus of the previous recent editorial comments of the Iberoamerican Journal of Strategic Management (IJSM. Its purpose of helping researchers and students in their quest to conduct quality research and publish it remains unchanged. These specific editorial comments are grouped in the menu section of the IJSM website under the title How to publish (or perish? (available at http://www.revistaiberoamericana.org/ojs/index.php/ibero/pages/view/publish%20or%20perish.

Activated rat hepatic stellate cells influence Th1/Th2 profile in vitro.

Science.gov (United States)

Xing, Zhi-Zhi; Huang, Liu-Ye; Wu, Cheng-Rong; You, Hong; Ma, Hong; Jia, Ji-Dong

2015-06-21

To investigate the effects of activated rat hepatic stellate cells (HSCs) on rat Th1/Th2 profile in vitro. Growth and survival of activated HSCs and CD4(+) T lymphocytes cultured alone or together was assessed after 24 or 48 h. CD4(+) T lymphocytes were then cultured with or without activated HSCs for 24 or 48 h and the proportion of Th1 [interferon (IFN)-γ(+)] and Th2 [interleukin (IL)-4(+)] cells was assessed by flow cytometry. Th1 and Th2 cell apoptosis was assessed after 24 h of co-culture using a caspase-3 staining procedure. Differentiation rates of Th1 and Th2 cells from CD4(+) T lymphocytes that were positive for CD25 but did not express IFN-γ or IL-4 were also assessed after 48 h of co-culture with activated HSCs. Galectin-9 expression in HSCs was determined by immunofluorescence and Western blotting. ELISA was performed to assess galectin-9 secretion from activated HSCs. Co-culture of CD4(+) T lymphocytes with activated rat HSCs for 48 h significantly reduced the proportion of Th1 cells compared to culture-alone conditions (-1.73% ± 0.71%; P Th1/Th2 ratio was significantly decreased (-0.44 ± 0.13; P Th1 cells was decreased (-65.71 ± 9.67; P Th1 (12.27% ± 0.99%; P Th1 cell apoptosis rate was significantly higher than in Th2 cells (P Th1 and Th2 cells; however, the increase in the proportion of Th2 cells was significantly higher than that of Th1 cells (1.85% ± 0.48%; P Th1/Th2 profile, inhibiting the Th1 response and enhancing the Th2 response, and this may be a novel pathway for liver fibrogenesis.

9th International Conference on Genetic and Evolutionary Computing

CERN Document Server

Lin, Jerry; Pan, Jeng-Shyang; Tin, Pyke; Yokota, Mitsuhiro; Genetic and Evolutionary Computing

2016-01-01

This volume of Advances in Intelligent Systems and Computing contains accepted papers presented at ICGEC 2015, the 9th International Conference on Genetic and Evolutionary Computing. The conference this year was technically co-sponsored by Ministry of Science and Technology, Myanmar, University of Computer Studies, Yangon, University of Miyazaki in Japan, Kaohsiung University of Applied Science in Taiwan, Fujian University of Technology in China and VSB-Technical University of Ostrava. ICGEC 2015 is held from 26-28, August, 2015 in Yangon, Myanmar. Yangon, the most multiethnic and cosmopolitan city in Myanmar, is the main gateway to the country. Despite being the commercial capital of Myanmar, Yangon is a city engulfed by its rich history and culture, an integration of ancient traditions and spiritual heritage. The stunning SHWEDAGON Pagoda is the center piece of Yangon city, which itself is famous for the best British colonial era architecture. Of particular interest in many shops of Bogyoke Aung San Market,...

9th International Conference Mechatronics 2011

CERN Document Server

Březina, Tomaš

2012-01-01

The book “Mechatronics: Recent Technological and Scientific Advances” provides comprehensive and accessible coverage of the evolving disciplines of mechatronics for nanotechnology, automatic control & robotics, biomedical engineering, design manufacturing and testing of MEMS, metrology, photonics, mechatronic products majors. It is already the third volume following the previous editions in 2007 and 2009 providing a recent state of advances in mechatronics presented on the 9th International Conference Mechatronics 2011, hosted this year at the Faculty of Mechatronics, Warsaw University of Technology, Poland.                                                                                                                                                                                               The carefully selecte...

Concentration of thorium isotopes and the activity ratios of 230Th/232Th and 228Th/232Th in seawater in the Pacific Ocean

International Nuclear Information System (INIS)

Miyake, Yasuo; Sugimura, Yukio; Yasujima, Tadahide.

1978-01-01

The concentration of thorium isotopes and the activity ratios of 230 Th/ 232 Th and 228 Th/ 232 Th in 500 l sea water samples collected in the Pacific Ocean were determined. Thorium isotopes were analyzed by alpha-ray spectrometry after separating them from other elements with an anion exchange resin. The average content of thorium ( 232 Th) of 0.9 ng l -1 was obtained in the open Pacific water. The average contents of 230 Th and 228 Th were 2.1 x 10 -2 pgl -1 and 1.2 agl -1 respectively. It was found that the ratios of 230 Th/ 232 Th and 228 Th/ 232 Th ranged respectively from 1.0 to 29, and from 0.4 to as high as 128. (author)

The Effect of Group Work on Misconceptions of 9th Grade Students about Newton's Laws

Science.gov (United States)

Ergin, Serap

2016-01-01

In this study, the effect of group work and traditional method on 9th grade students' misconceptions about Newton Laws was investigated. The study was conducted in three classes in an Anatolian Vocational High School in Ankara/Turkey in the second term of the 2014-2015 academic year. Two of these classes were chosen as the experimental group and…

L'acquisition et la construction de la notion de temps chez les enfants de 5 à 9 ans: perspective développementale

OpenAIRE

De Coster, Lotta

2004-01-01

Cette recherche porte sur l’acquisition et la construction de la notion de temps chez les enfants de 5 à 9 ans, c’est-à-dire ceux qui fréquentent des classes allant de la 3e maternelle à la 3e année primaire. Dans la partie théorique nous analysons les différentes notions constitutives qui caractérisent le temps :l’ordre de succession, la durée, le cycle, l’irréversibilité, l’horizon temporel. Nous nous intéressons également aux notions linguistiques ainsi qu’aux notions associées telles que ...

The IntFOLD server: an integrated web resource for protein fold recognition, 3D model quality assessment, intrinsic disorder prediction, domain prediction and ligand binding site prediction.

Science.gov (United States)

Roche, Daniel B; Buenavista, Maria T; Tetchner, Stuart J; McGuffin, Liam J

2011-07-01

The IntFOLD server is a novel independent server that integrates several cutting edge methods for the prediction of structure and function from sequence. Our guiding principles behind the server development were as follows: (i) to provide a simple unified resource that makes our prediction software accessible to all and (ii) to produce integrated output for predictions that can be easily interpreted. The output for predictions is presented as a simple table that summarizes all results graphically via plots and annotated 3D models. The raw machine readable data files for each set of predictions are also provided for developers, which comply with the Critical Assessment of Methods for Protein Structure Prediction (CASP) data standards. The server comprises an integrated suite of five novel methods: nFOLD4, for tertiary structure prediction; ModFOLD 3.0, for model quality assessment; DISOclust 2.0, for disorder prediction; DomFOLD 2.0 for domain prediction; and FunFOLD 1.0, for ligand binding site prediction. Predictions from the IntFOLD server were found to be competitive in several categories in the recent CASP9 experiment. The IntFOLD server is available at the following web site: http://www.reading.ac.uk/bioinf/IntFOLD/.

A formação do intérprete educacional e sua atuação em sala de aula

Directory of Open Access Journals (Sweden)

Luiz Cláudio Oliveira Antonio

2015-10-01

Full Text Available É fundamental contar com a participação do intérprete educacional de Língua de Sinais (LS na inclusão. Esse artigo aborda a formação e as diferentes funções dos intérpretes em contextos educacionais inclusivos. Basta ser conhecedor da LS? Isso garante ao intérprete o sucesso em sua função? É preciso também agir como mediador entre professor e os alunos surdos, buscando promover a compreensão. Nessa pesquisa foram realizadas entrevistas semiestruturadas com onze intérpretes que atuam na inclusão, buscando conhecer a formação inicial, o tempo de exercício profissional, quais as motivações e quais as funções que desempenha na sala de aula e na escola. Resultados apontam a ausência de planejamento conjunto professor-intérprete e de acesso prévio aos conteúdos apresentados em sala. Verificou-se que quando o intérprete age pedagogicamente, crianças surdas aprendem mais.

Intégration des Tice et apprentissage de l'enseignement : une approche systémique Integrating technology and learning to teach: a systemic perspective

Directory of Open Access Journals (Sweden)

Francis Bangou

2006-11-01

Full Text Available De nombreuses études soulignent à quel point il est complexe d'analyser les changements pédagogiques entraînés par l'intégration des Tice. Cette recherche-action tente d'analyser de façon systémique les interrelations qu'entretient l'intégration des Tice avec les changements pédagogiques dans le cadre d'un programme de formation d'enseignants en langues étrangères au sein d'une grande université américaine. Le cadre théorique nous permettra tout d'abord de délimiter une perspective systémique et de présenter notre conception de l'intégration des Tice et de l'apprentissage. Puis, nous présenterons notre étude et en résumerons les principaux résultats afin d'illustrer la complexité d'une telle relation.Many studies underline how difficult it is to analyse the pedagogical changes caused by the integration of technology. This action research aims to analyse, from a systemic point of view, the interrelations that exist between the integration of technology and pedagogical change. The study took place in a foreign and second language teacher education program at a large American university. First, we will define a systemic perspective as well as the concepts of technology integration and learning. Then, to illustrate the complexity of such relationship, we will describe our study and summarize the main results.

O tradutor/intérprete de língua de sinais: um mediador de fronteiras culturais

Directory of Open Access Journals (Sweden)

Izaulita César Moura

2017-01-01

Full Text Available Discute-se a importância do tradutor/intérprete de Língua de Sinais enquanto um mediador de fronteiras entre dois mundos culturais. Busca-se dar visibilidade à complexidade da tarefa do intérprete não apenas no campo da linguagem, mas também na área da subjetividade, levando em conta contribuições da Psicanálise. Partiu-se de uma pesquisa qualitativa realizada no Instituto Nacional de Educação de Surdos que abordou o tema da linguagem e subjetividade com alunos com surdez profunda. Concluiu-se que o papel social e subjetivo do intérprete de Libras precisa ser mais bem compreendido. O desafio não é apenas traduzir e informar, mas saber guardar os próprios pensamentos e sentimentos, para ser porta voz da fala, da expressão e da emoção de outra pessoa, de um sujeito que se manifesta em total alteridade. Assim, facetas menos conhecidas do papel intersubjetivo do tradutor/intérprete são apontadas.

9th International Conference on 3D Radiation Dosimetry

International Nuclear Information System (INIS)

2017-01-01

IC3DDose 2016 - 9th International Conference on 3D Radiation Dosimetry Preface It was a great pleasure to welcome participants to IC3DDose 2016, the 9th International Conference on 3D Radiation Dosimetry, held from 7–10 November 2016 in Galveston, Texas. The series of conferences has evolved considerably during its history. At the first conference, DOSGEL’99, the discussion centered around gel dosimetry. Held in Lexington, Kentucky in 1999, it was timed to coincide with the American Association of Physicists in Medicine (AAPM) Annual Meeting in Nashville, Tennessee. It was my honour to organize that first conference, and it was once again my honour to organize the 9th conference in the series now known as IC3DDose which was held in Galveston, Texas. As was the case with recent IC3DDose conferences, the topic has broadened considerably beyond gel dosimetry. Not only have newer 3D volumetric dosimeters appeared on the scene, but novel electronic dosimetry systems and software that generate quasi-3D dose information have also. These changes have tracked advances in radiation oncology as techniques such as IMRT, VMAT, and IGRT have become almost ubiquitous. At the same time, dynamic treatments including gating and tracking now enjoy widespread use. Novel treatment technologies have appeared with perhaps the most disruptive being combined MR imaging-treatment units such as the ViewRay MR-cobalt unit and the Elekta/Philips MR-Linac. The potential benefits offered by 3D dosimetry were explored, compared and evaluated during IC3DDose 2016. Novel and improved readout techniques, some of which take advantage of the contemporary treatment environment and new QA systems and procedures, as well as other aspects of clinical dosimetry were well represented in the program. Over the past several years, the importance of safety in radiation therapy has been highlighted. The benefits of 3D dosimetry in contributing to safe and accurate treatments cannot be overstated. The

La théorie sémiotique littéraire de Michael Riffaterre : matrice, intertexte et interprétant

Directory of Open Access Journals (Sweden)

John Hopkins

2005-04-01

Full Text Available Cette communication présentée lors d’un séminaire du CNA, présente une vision de la théorie littéraire de Michael Riffaterre et propose d’en compléter la portée par un apport théorique nouveau. La dernière partie examine les rapports de la théorie riffaterrienne avec le roman. Sémiotique, poésie, matrice, structure bimatricielle, Riffaterre, Baudelaire. Puisque je parle aux confins du Centre de Narratologie Appliquée, où l’on s’intéresse principalement aux questions de la structure et de...

75 FR 17742 - Filing Dates for the Georgia Special Election in the 9th Congressional District

Science.gov (United States)

2010-04-07

... 9th Congressional District AGENCY: Federal Election Commission. ACTION: Notice of filing dates for special election. SUMMARY: Georgia has scheduled a special general election on May 11, 2010, to fill the U... participate in the Georgia Special General and Special Runoff Elections shall file a 12-day Pre-General Report...

Intelligent Virtual Agents : 9th International Conference, IVA 2009 Amsterdam, The Netherlands, September 14-16, 2009 Proceedings

NARCIS (Netherlands)

Ruttkay, Z.M.; Kipp, M.; Nijholt, Antinus; Vilhjalmsson, H.H.

2009-01-01

Welcome to the Proceedings of the 9th International Conference on Intelligent Virtual Agents, held 14-16 September, 2009 in Amsterdam, The Netherlands. Intelligent Virtual Agents (IVAs) are interactive characters that exhibit humanlike qualities and communicate with humans or with each other using

INITIAL DATA RELEASE OF THE KEPLER-INT SURVEY

Energy Technology Data Exchange (ETDEWEB)

Greiss, S.; Steeghs, D.; Gaensicke, B. T. [Department of Physics, Astronomy and Astrophysics group, University of Warwick, CV4 7AL Coventry (United Kingdom); Martin, E. L. [INTA-CSIC Centro de Astrobiologia, Carretera de Ajalvir km 4, 28550 Torrejon de Ardoz (Spain); Groot, P. J.; Verbeek, K.; Jonker, P. G.; Scaringi, S. [Department of Astrophysics/IMAPP, Radboud University Nijmegen, P.O. Box 9010, 6500 GL Nijmegen (Netherlands); Irwin, M. J.; Gonzalez-Solares, E. [Cambridge Astronomy Survey Unit, Institute of Astronomy, University of Cambridge, Madingley Road, CB3 0HA Cambridge (United Kingdom); Greimel, R. [Institut fuer Physik, Karl-Franzen Universitaet Graz, Universitaetsplatz 5, 8010 Graz (Austria); Knigge, C. [School of Physics and Astronomy, University of Southampton, Southampton, Hampshire SO17 1BJ (United Kingdom); Ostensen, R. H. [Instituut voor Sterrenkunde, KU Leuven, Celestijnenlaan 200D, 3001 Leuven (Belgium); Drew, J. E.; Farnhill, H. [Centre for Astrophysics Research, University of Hertfordshire, College Lane, Hatfield AL10 9AB (United Kingdom); Drake, J.; Wright, N. J. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Ripepi, V. [INAF-Osservatorio Astronomico di Capodimonte, via Moiariello 16, Naples I-80131 (Italy); Southworth, J. [Astrophysics Group, Keele University, Newcastle-under-Lyme ST5 5BG (United Kingdom); Still, M., E-mail: s.greiss@warwick.ac.uk [NASA Ames Research Center, M/S 244-40, Moffett Field, CA 94035 (United States); and others

2012-07-15

This paper describes the first data release of the Kepler-INT Survey (KIS) that covers a 116 deg{sup 2} region of the Cygnus and Lyra constellations. The Kepler field is the target of the most intensive search for transiting planets to date. Despite the fact that the Kepler mission provides superior time-series photometry, with an enormous impact on all areas of stellar variability, its field lacks optical photometry complete to the confusion limit of the Kepler instrument necessary for selecting various classes of targets. For this reason, we follow the observing strategy and data reduction method used in the IPHAS and UVEX galactic plane surveys in order to produce a deep optical survey of the Kepler field. This initial release concerns data taken between 2011 May and August, using the Isaac Newton Telescope on the island of La Palma. Four broadband filters were used, U, g, r, i, as well as one narrowband one, H{alpha}, reaching down to a 10{sigma} limit of {approx}20th mag in the Vega system. Observations covering {approx}50 deg{sup 2}, thus about half of the field, passed our quality control thresholds and constitute this first data release. We derive a global photometric calibration by placing the KIS magnitudes as close as possible to the Kepler Input Catalog (KIC) photometry. The initial data release catalog containing around 6 million sources from all the good photometric fields is available for download from the KIS Web site (www.astro.warwick.ac.uk/research/kis/) as well as via MAST (KIS magnitudes can be retrieved using the MAST enhanced target search page http://archive.stsci.edu/kepler/kepler{sub f}ov/search.php and also via Casjobs at MAST Web site http://mastweb.stsci.edu/kplrcasjobs/).

INITIAL DATA RELEASE OF THE KEPLER-INT SURVEY

International Nuclear Information System (INIS)

Greiss, S.; Steeghs, D.; Gänsicke, B. T.; Martín, E. L.; Groot, P. J.; Verbeek, K.; Jonker, P. G.; Scaringi, S.; Irwin, M. J.; González-Solares, E.; Greimel, R.; Knigge, C.; Østensen, R. H.; Drew, J. E.; Farnhill, H.; Drake, J.; Wright, N. J.; Ripepi, V.; Southworth, J.; Still, M.

2012-01-01

This paper describes the first data release of the Kepler-INT Survey (KIS) that covers a 116 deg 2 region of the Cygnus and Lyra constellations. The Kepler field is the target of the most intensive search for transiting planets to date. Despite the fact that the Kepler mission provides superior time-series photometry, with an enormous impact on all areas of stellar variability, its field lacks optical photometry complete to the confusion limit of the Kepler instrument necessary for selecting various classes of targets. For this reason, we follow the observing strategy and data reduction method used in the IPHAS and UVEX galactic plane surveys in order to produce a deep optical survey of the Kepler field. This initial release concerns data taken between 2011 May and August, using the Isaac Newton Telescope on the island of La Palma. Four broadband filters were used, U, g, r, i, as well as one narrowband one, Hα, reaching down to a 10σ limit of ∼20th mag in the Vega system. Observations covering ∼50 deg 2 , thus about half of the field, passed our quality control thresholds and constitute this first data release. We derive a global photometric calibration by placing the KIS magnitudes as close as possible to the Kepler Input Catalog (KIC) photometry. The initial data release catalog containing around 6 million sources from all the good photometric fields is available for download from the KIS Web site (www.astro.warwick.ac.uk/research/kis/) as well as via MAST (KIS magnitudes can be retrieved using the MAST enhanced target search page http://archive.stsci.edu/kepler/kepler_fov/search.php and also via Casjobs at MAST Web site http://mastweb.stsci.edu/kplrcasjobs/).

Apport de la théorie du sentiment d’autoefficacité pour le développement de la compétence technopédagogique des futurs enseignants

Directory of Open Access Journals (Sweden)

Sonia Lefebvre

2015-01-01

Full Text Available Le texte s’intéresse à la formation technopédagogique des futurs enseignants, et plus précisément, aux pratiques à déployer en formation initiale pour accroître leur compétence professionnelle à intégrer les TIC. Les pratiques proposées prennent appui sur la théorie du sentiment d’autoefficacité d’Albert Bandura, ce sentiment pouvant influencer leur compétence à intégrer les TIC. Appuyé par des travaux empiriques, le texte aborde les sources susceptibles d’influencer l’autoefficacité à intégrer les TIC dans un cadre pédagogique et identifie des pistes d’action à envisager. Enfin, la réflexion amène à repenser les interventions des formateurs tant en formation initiale qu’en formation continue et à remettre en question, sur le plan empirique, les dispositifs de formation.

BioInt: an integrative biological object-oriented application framework and interpreter.

Science.gov (United States)

Desai, Sanket; Burra, Prasad

2015-01-01

BioInt, a biological programming application framework and interpreter, is an attempt to equip the researchers with seamless integration, efficient extraction and effortless analysis of the data from various biological databases and algorithms. Based on the type of biological data, algorithms and related functionalities, a biology-specific framework was developed which has nine modules. The modules are a compilation of numerous reusable BioADTs. This software ecosystem containing more than 450 biological objects underneath the interpreter makes it flexible, integrative and comprehensive. Similar to Python, BioInt eliminates the compilation and linking steps cutting the time significantly. The researcher can write the scripts using available BioADTs (following C++ syntax) and execute them interactively or use as a command line application. It has features that enable automation, extension of the framework with new/external BioADTs/libraries and deployment of complex work flows.

30. MPA-Seminar 'Safety and reliability in energy technology' in conjunction with the 9th German-Japanese seminar. Vol. 2 (Papers 27-53)

International Nuclear Information System (INIS)

Roos, E.

2004-01-01

he 30th MPA-seminar on ''Safety and Availability in Energy Engineering'' was held in conjuction with the 9th German-Japanese Seminar. The 52 contributions were published in two volumes. Volume 1 contains the contributions to the following sessions: fracture mechanics, fatigue, welding, environmental impact and European research projects. Volume 2 contains contributions of sessions 6-9: high-temperature application, modelling-simulation, ageing management and non-destructive testing. (uke)

30. MPA-Seminar 'Safety and reliability in energy technology' in conjunction with the 9th German-Japanese seminar. Vol. 1 (Papers 1-26)

International Nuclear Information System (INIS)

Roos, E.

2004-01-01

The 30th MPA-seminar on ''Safety and Availability in Energy Engineering'' was held in conjuction with the 9th German-Japanese Seminar. The 52 contributions were published in two volumes. Volume 1 contains the contributions to the following sessions: fracture mechanics, fatigue, welding, environmental impact and European research projects. Volume 2 contains contributions of sessions 6-9: high-temperature application, modelling-simulation, ageing management and non-destructive testing. (uke)

9th Asian Conference on Intelligent Information and Database Systems

CERN Document Server

Nguyen, Ngoc; Shirai, Kiyoaki

2017-01-01

This book presents recent research in intelligent information and database systems. The carefully selected contributions were initially accepted for presentation as posters at the 9th Asian Conference on Intelligent Information and Database Systems (ACIIDS 2017) held from to 5 April 2017 in Kanazawa, Japan. While the contributions are of an advanced scientific level, several are accessible for non-expert readers. The book brings together 47 chapters divided into six main parts: • Part I. From Machine Learning to Data Mining. • Part II. Big Data and Collaborative Decision Support Systems, • Part III. Computer Vision Analysis, Detection, Tracking and Recognition, • Part IV. Data-Intensive Text Processing, • Part V. Innovations in Web and Internet Technologies, and • Part VI. New Methods and Applications in Information and Software Engineering. The book is an excellent resource for researchers and those working in algorithmics, artificial and computational intelligence, collaborative systems, decisio...

Advances in Computer Entertainment : 9th International Conference, ACE 2012, Kathmandu, Nepal, November 3-5, 2012. Proceedings

NARCIS (Netherlands)

Nijholt, Anton; Romão, Teresa; Reidsma, Dennis

2012-01-01

This book constitutes the refereed conference proceedings of the 9th International Conference on Advances in Computer Entertainment, ACE 2012, held in Kathmandu, Nepal, in November 2012. The 10 full paper and 19 short papers presented together with 5 papers from the special track Arts and Culture

76 FR 45797 - Filing Dates for the New York Special Election in the 9th Congressional District

Science.gov (United States)

2011-08-01

... 9th Congressional District AGENCY: Federal Election Commission. ACTION: Notice of filing dates for special election. SUMMARY: New York has scheduled a Special General Election on September 13, 2011, to.... Committees required to file reports in connection with the Special General Election on September 13, 2011...

The Effectiveness of a Self Regulated Learning-Based Training Program on Improving Cognitive and Metacognitive EFL Reading Comprehension of 9th Graders with Reading Disabilities

Science.gov (United States)

Eissa, Mourad Ali

2015-01-01

The purpose of this study was to explore the effect of a self regulated learning intervention program on cognitive and metacognitive EFL reading comprehension of 9th graders with reading disabilities. The participants in this study were 40 9th Graders with reading disabilities, selected from two schools located in Baltim Educational Edara. A…

Démarche intégrée pour assurer la sécurité alimentaire et ...

International Development Research Centre (IDRC) Digital Library (Canada)

Démarche intégrée pour assurer la sécurité alimentaire et nutritionnelle aux Philippines. La malnutrition demeure un problème grave aux Philippines, notamment chez les enfants. La mise en place de programmes intégrés de nutrition et de culture potagère dans les écoles pourrait-elle contribuer à remédier à ce problème ...

9th International Conference on Software Engineering Research, Management and Applications(SERA 2011)

CERN Document Server

Software Engineering Research, Management and Applications 2011

2012-01-01

The purpose of the 9th International Conference on Software Engineering Research, Management and Applications(SERA 2011) held on August 10-12, 2011 in Baltimore, Maryland was to bring together scientists, engineers, computer users, and students to share their experiences and exchange new ideas and research results about all aspects (theory, applications and tools) of computer and information sciences, and to discuss the practical challenges encountered along the way and the solutions adopted to solve them.   The conference organizers selected 12 outstanding papers from SERA 2011, all of which you will find in this volume of Springer’s Studies in Computational Intelligence.

The Tick Salivary Protein Sialostatin L Inhibits the Th9-Derived Production of the Asthma-Promoting Cytokine IL-9 and Is Effective in the Prevention of Experimental Asthma

Czech Academy of Sciences Publication Activity Database

Horká, Helena; Staudt, V.; Klein, M.; Taube, Ch.; Reuter, S.; Dehzad, N.; Andersen, J. F.; Kopecký, Jan; Schild, H.; Kotsyfakis, Michalis; Hoffmann, M.; Gerlitzki, B.; Stassen, M.; Bopp, T.; Schmitt, E.

2012-01-01

Roč. 188, č. 6 (2012), s. 2669-2676 ISSN 0022-1767 R&D Projects: GA ČR GCP302/11/J029; GA MŠk(CZ) LC06009 Institutional support: RVO:60077344 Keywords : experimental asthma * airway hyperresponsiveness * eosinophilia * interleukin-9 * Th9 cells * Sialostatin L * therapeutic * Ixodes scapularis * cysteine protease inhibitor * tick saliva Subject RIV: EC - Immunology Impact factor: 5.520, year: 2012

XII — Taux de l’intérêt, taux de l’escompte, prix de l’or

OpenAIRE

Juglar, Clément

2014-01-01

[Taux de l’intérêt à long et à court terme. — Qu’est-ce qui règle le taux de l’intérêt ? — Variations du taux de l’intérêt en France et en Angleterre. — Taux de l’escompte. Écart de prix entre les ventes à terme et les ventes au comptant. — La banque ne commandite pas le travail, elle fait circuler le crédit. — Le taux de capitalisation des rentes ne suit pas le taux de l’escompte. — Influence de la hausse de l’escompte. — Hausse de l’escompte, prix de l’or, flux et reflux des métaux précieux...

9th International Frumkin symposium: Electrochemical technologies and materials for 21st century. Abstracts

Energy Technology Data Exchange (ETDEWEB)

NONE

2010-07-01

Abstracts of the 9th International Frumkin symposium: Electrochemical technologies and materials for 21st century are presented. The symposium was held 24-29 October 2010 in Moscow. The symposium included the following microsymposiums: Electrical double layer and electrochemical kinetics (from phenomenological to molecular level); New processes, materials and devices for successful electrochemical transformation of energy; Corrosion and protection of materials; General and local corrosion; Electroactive composition materials; Bioelectrochemistry. The Frumkin symposium includes plenary lectures, oral and poster presentations. Official language of the symposium is English

9th International Frumkin symposium: Electrochemical technologies and materials for 21st century. Abstracts

International Nuclear Information System (INIS)

2010-01-01

Abstracts of the 9th International Frumkin symposium: Electrochemical technologies and materials for 21st century are presented. The symposium was held 24-29 October 2010 in Moscow. The symposium included the following microsymposiums: Electrical double layer and electrochemical kinetics (from phenomenological to molecular level); New processes, materials and devices for successful electrochemical transformation of energy; Corrosion and protection of materials; General and local corrosion; Electroactive composition materials; Bioelectrochemistry. The Frumkin symposium includes plenary lectures, oral and poster presentations. Official language of the symposium is English [ru

Progrès de l'intégration régionale, rôle et stratégie du Groupe de la

International Development Research Centre (IDRC) Digital Library (Canada)

mgv3643

8 déc. 2009 ... 1. Progrès de l‟Intégration Régionale,. Rôle et Stratégie du Groupe de la Banque Africaine de Développement dans la promotion de l‟intégration régionale en Afrique. Gabriel Mougani. Département NEPAD, Intégration Régionale et Commerce ...

Construction d’un outil pour évaluer le degré d’intégration des TIC dans l’enseignement

Directory of Open Access Journals (Sweden)

Pierre-François Coen

2006-01-01

Full Text Available Après un bref survol des enjeux liés à l’intégration des TIC dans l’enseignement, cet article présente le processus de construction d’un instrument (les Vignettes de situation pour l’intégration des TIC ou Visi-TIC destiné à évaluer le degré d’intégration des TIC dans l’enseignement. Il présente les différentes étapes d’élaboration et de validation de cet outil. Proposé en deux variantes (française/allemande pour des élèves âgés de 6 à 7 ans jusqu’à 18 ans, ce nouvel outil s’appuie sur le modèle systémique de l’innovation de Depover et Strebelle (1997, et présente l’avantage d’envisager l’intégration des TIC dans une dynamique de changement.

Byzantine influence on the Serbian customary law in the 9th century

Directory of Open Access Journals (Sweden)

Đekić Đorđe N.

2016-01-01

Full Text Available By the 10th century Serbian law recognized the following ways of dispute resolution: revenge and appeasement, and it may be indirectly proved that there was a system of compensation. As punishments, there was banishment into exile, blinding and a death sentence. Since revenge, appeasement and compensation system appear in the pre-state period, while the death penalty has its roots in the blood feud, that indicates they are all of local origin. A question remains about the origin of banishment and blinding a fallen ruler, that is, a rival to the throne. In the first half of the 9th century the Byzantine Empire managed to reinstate its power over the Adriatic Sea, to impose itself over the Serbian states, to Christianise them and to legalise ruling families in the Serbian lands. Suffice to say that in 869 the Serbian states fight wars on the Byzantine side. Origin of influences on the ways of the punishment we seek in Byzantium, or better still, in its legal practice. It has been found that Byzantium used to send their conquered rivals to the throne into exile, punishing them by blinding them, so we draw a conclusion that in the matter of punishment, i.e. in the customary law, it exercised its influence on Serbia.

The Factor Structure of Coordination Abilities Development in 5th-7th Grade Boys

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В. В. Приходько

2017-12-01

Full Text Available The objective is to determine the structure of coordination abilities development in 5th-7th grade boys. Materials and methods. The participants in the study were boys of the 5th grade (n=21, 6th grade (n=20, and 7th grade (n=19. The paper used analysis and generalization of the scientific and methodological literature data, general scientific methods of theoretical level, namely: analogy, analysis, synthesis, abstracting, induction, as well as general scientific methods of empirical level: observation, testing, experiment. To evaluate of the motor preparedness, the results of motor tests, height and body weight were recorded. The materials of the study were processed in the statistical analysis program IBM SPSS 20. Factor analysis was carried out using a model of the principal components with the rotation method: Variamax with Kaiser normalization. Results. Analysis of the similarities shows that the most informative in the structure of the 5th grade boys’ motor preparedness are Test 9 “Static Equilibrium Evaluation by E. Ya. Bondarevsky’s Method” (,999, Test 2 “Standing Long Jump (cm” (,998, Test 10 “Dynamic Equilibrium Evaluation by Bess Method” (,916; for the 6th grade boys such are Test 9 “Static Equilibrium Evaluation by E. Ya. Bondarevsky’s Method” (1.0, Test 2 “Standing Long Jump (cm” (,999, Test 5 “Sit-Up for 30 sec.” (,968, Test 10 “Dynamic Equilibrium Evaluation by Bess Method” (,918; for the 7th grade boys such are Test 2 “Standing Long Jump (cm” (,994, Test 9 “Static Equilibrium Evaluation by E. Ya. Bondarevsky’s Method” (,987, Test 10 “Dynamic Equilibrium Evaluation by Bess Method” (,945. Conclusions. The most informative in the structure of 5th-7th grade boys’ coordination abilities is vestibular tolerance. For pedagogical control of 5th-7th grade boys’ motor preparedness the following can be recommended: Test 2 “Standing Long Jump (cm”, Test 9 “Static Equilibrium

Proteomic landscape in Central and Eastern Europe: the 9th Central and Eastern European Proteomic Conference, Poznań, Poland.

Science.gov (United States)

Gadher, Suresh Jivan; Marczak, Łukasz; Łuczak, Magdalena; Stobiecki, Maciej; Widlak, Piotr; Kovarova, Hana

2016-01-01

Every year since 2007, the Central and Eastern European Proteomic Conference (CEEPC) has excelled in representing state-of-the-art proteomics in and around Central and Eastern Europe, and linking it to international institutions worldwide. Its mission remains to contribute to all approaches of proteomics including traditional and often-revisited methodologies as well as the latest technological achievements in clinical, quantitative and structural proteomics with a view to systems biology of a variety of processes. The 9th CEEPC was held from June 15th to 18th, 2015, at the Institute of Bioorganic Chemistry, Polish Academy of Sciences in Poznań, Poland. The scientific program stimulated exchange of proteomic knowledge whilst the spectacular venue of the conference allowed participants to enjoy the cobblestoned historical city of Poznań.

International Symposium on Gas Kinetics (9th) Held in Bordeaux, France on 20-25 July 1986. Abstracts

Science.gov (United States)

1986-07-25

versidad a Distancia, Ciudad Universitaria, 28040 Madrid. 3.M. Fiquera, J. Medina and 3.C. Rodriguez, Int de Quimica Fi sica "Rocasolano", CSIC, Serrano...inhibition. N J3 By making sensible (we hopel) assumptions about the reactivity of C 2115 towards allylic It, we estimate for 798 K and 50 Torr n-hexane

S’exercer à l’empathie : une expérience pédagogique en design d’intérieur

Directory of Open Access Journals (Sweden)

Rabah Bousbaci

2010-11-01

de l’autre, de le comprendre et de ressentir ses sentiments et ses émotions, est bien adapté pour explorer cette attitude. Cet article est composé de deux parties. La première présente une expérience pédagogique en design d’intérieur où des étudiants apprennent à se représenter les usagers de leur projet d’aménagement en utilisant un outil méthodologique appelé « boussole éthique ». Cette boussole est constituée essentiellement de trois pôles qui renvoient aux trois rapports fondamentaux de l’être humain tels qu’étudiés dans la tradition stoïcienne : rapport à soi-même, à autrui et à la nature. Dans la seconde partie, l’article met en relief plusieurs éléments théoriques qui permettent de comprendre, de consolider et, éventuellement, de faire évoluer les bases conceptuelles qui sous-tendent cette démarche. Il s’agira notamment des théories éthiques et de certaines approches spécifiques au concept de l’empathie.

Preferential Th1 cytokine profile of phosphoantigen-stimulated human Vγ9Vδ2 T cells.

LENUS (Irish Health Repository)

Dunne, Margaret R

2010-01-01

Human Vγ9Vδ2 T cells recognise pyrophosphate-based antigens (phosphoantigens) and have multiple functions in innate and adaptive immunity, including a unique ability to activate other cells of the immune system. We used flow cytometry and ELISA to define the early cytokine profiles of Vγ9Vδ2 T cells stimulated in vitro with isopentenyl pyrophosphate (IPP) and (E)-4-hydroxy-3-methyl-but-2 enyl pyrophosphate (HMB-PP) in the absence and presence of IL-2 and IL-15. We show that fresh Vγ9Vδ2 T cells produce interferon-γ (IFN-γ) and tumour necrosis factor-α (TNF-α) within 4 hours of stimulation with phosphoantigen, but neither IL-10, IL-13, nor IL-17 was detectable up to 72 hours under these conditions. Cytokine production was not influenced by expression or lack, thereof, of CD4 or CD8. Addition of IL-2 or IL-15 caused expansion of IFN-γ-producing Vγ9Vδ2 T cells, but did not enhance IFN-γ secretion after 24-72 hours. Thus, phosphoantigen-stimulated Vγ9Vδ2 T cells have potential as Th1-biasing adjuvants for immunotherapy.

Preferential Th1 Cytokine Profile of Phosphoantigen-Stimulated Human Vγ9Vδ2 T Cells

Directory of Open Access Journals (Sweden)

Margaret R. Dunne

2010-01-01

Full Text Available Human Vγ9Vδ2 T cells recognise pyrophosphate-based antigens (phosphoantigens and have multiple functions in innate and adaptive immunity, including a unique ability to activate other cells of the immune system. We used flow cytometry and ELISA to define the early cytokine profiles of Vγ9Vδ2 T cells stimulated in vitro with isopentenyl pyrophosphate (IPP and (E-4-hydroxy-3-methyl-but-2 enyl pyrophosphate (HMB-PP in the absence and presence of IL-2 and IL-15. We show that fresh Vγ9Vδ2 T cells produce interferon-γ (IFN-γ and tumour necrosis factor-α (TNF-α within 4 hours of stimulation with phosphoantigen, but neither IL-10, IL-13, nor IL-17 was detectable up to 72 hours under these conditions. Cytokine production was not influenced by expression or lack, thereof, of CD4 or CD8. Addition of IL-2 or IL-15 caused expansion of IFN-γ-producing Vγ9Vδ2 T cells, but did not enhance IFN-γ secretion after 24–72 hours. Thus, phosphoantigen-stimulated Vγ9Vδ2 T cells have potential as Th1-biasing adjuvants for immunotherapy.

Méthode intégro-variationnelle appliquée aux probèmes intérieur et extérieur avec surface libre de l'hydrodynamique linéaire Integro-Variational Method Applied to Indoor and Outdoor Problems with a Free Surface of Linear Hydrodinamics

Directory of Open Access Journals (Sweden)

Berhault C.

2006-11-01

Full Text Available Le but de cet article est de montrer que l'on peut appliquer une rintégro-variationnelle pour résoudre les problèmes intérieur (comportementliquide en milieu confiné et extérieur (diffraction-radiation de l'hydrodynamique linéaire. Une comparaison des résultats obtenus pour le problème intérieur dans Q les méthodes classiques : équation intégrale (singularités et formulation rationnelle (éléments finis, montre les avantages de cette méthode. The aim of this article is to show that an integro-variational method can be applied for solving interior (behavior of a liquid in a confined environment and exterior (diffraction-radiation problems of linear hydrodynamics. A comparison of the results obtained for the interior problem in IR2 with conventional methods, i.e. intégral équation (singularities and variational formulation (finite elements, shows the advantages of this method.

The Use of Monograms on Byzantine Seals in the Early Middle-Ages (6th to 9th Centuries)

OpenAIRE

Werner Seibt

2016-01-01

The paper deals especially with monograms on Byzantine lead seals. The early form was the block monogram, a type used already in Classical times, which came into fashion in the Byzantine world in the 6th or already in the 5th century and remained important till the early 7th century. Such monograms hide normally a name, a title or an office, the Greek ones in genitive, the Latin ones in nominative or genitive. Many of them can be read in different ways. For the double using of parts of letter...

Production of 231Pa and 232U by irradiation of 230Th/232Th mixtures

International Nuclear Information System (INIS)

Kluge, E.; Lieser, K.H.

1981-01-01

The production of 231 Pa and of 232 U by irradiating a 230 Th/ 232 Th mixture (containing 12 mol per cent 230 Th) in form of ThO 2 at a thermal neutron flux of 6.9 x 10 13 cm -2 s -1 for 4 months was investigated. Pa, U and Th were separated and the chemical yields were determined. 2.6% of the 230 Th were transformed into 231 Pa and 0.13% into 232 U. These values are higher than those calculated for a thermal flux, but lower than those calculated for a flux ratio epithermal to thermal = 0.03. 231 Pa and 232 U were isolated in form of a protactinium solution and of U 3 O 8 with 94.9 and 89.1% chemical yields, respectively. Foreign activities were not detected. Thorium was recuperated and isolated as ThO 2 , with a chemical yield of 93.6%. (orig.)

Biglycan, a novel trigger of Th1 and Th17 cell recruitment into the kidney.

Science.gov (United States)

Nastase, Madalina-Viviana; Zeng-Brouwers, Jinyang; Beckmann, Janet; Tredup, Claudia; Christen, Urs; Radeke, Heinfried H; Wygrecka, Malgorzata; Schaefer, Liliana

2017-12-15

Th1 and Th17 cells, T helper (Th) subtypes, are key inducers of renal fibrosis. The molecular mechanisms of their recruitment into the kidney, however, are not well understood. Here, we show that biglycan, a proteoglycan of the extracellular matrix, acting in its soluble form as a danger signal, stimulates autonomously the production of Th1 and Th17 chemoattractants CXCL10 and CCL20 in macrophages. In the presence of IFNγ, biglycan synergistically stimulates CXCL9. In macrophages deficient for TLR2, TLR4, and their adaptor molecules MyD88 or TRIF, we identified highly selective mechanisms of biglycan-dependent Th1/17 chemoattraction. Thus, the expression of CXCL9 and CXCL10, common chemoattractants for CXCR3-positive Th1 and Th17 cells, is triggered in a biglycan-TLR4/TRIF-dependent manner. By contrast, biglycan induces CCL20 chemokine production, responsible for CCR6-positive Th17 cell recruitment, in a TLR2/4/MyD88-dependent manner. Importantly, at the onset of diabetes mellitus and lupus nephritis we provide evidence for biglycan-dependent recruitment of Th1 and Th17 cells, IFNγ and IL-17 production, and development of albuminuria in mice lacking or overexpressing soluble biglycan. Furthermore, by genetic ablation of Cxcl10 we showed in vivo involvement of this chemokine in biglycan-dependent recruitment of Th1 and Th17 cells into the kidney. Finally, a positive correlation of biglycan and CXCL10/CXCL9 levels was detected in plasma from patients with diabetic nephropathy and lupus nephritis. Taken together, we identified biglycan as a novel trigger of Th1 and Th17 cell recruitment into the kidney and we postulate that interfering with biglycan/TLR/TRIF/MyD88-signaling might provide novel therapeutic avenues for renal fibrosis. Copyright © 2017 International Society of Matrix Biology. Published by Elsevier B.V. All rights reserved.

Nineth Rib Syndrome after 10(th) Rib Resection.

Science.gov (United States)

Yu, Hyun Jeong; Jeong, Yu Sub; Lee, Dong Hoon; Yim, Kyoung Hoon

2016-07-01

The 12(th) rib syndrome is a disease that causes pain between the upper abdomen and the lower chest. It is assumed that the impinging on the nerves between the ribs causes pain in the lower chest, upper abdomen, and flank. A 74-year-old female patient visited a pain clinic complaining of pain in her back, and left chest wall at a 7 on the 0-10 Numeric Rating scale (NRS). She had a lateral fixation at T12-L2, 6 years earlier. After the operation, she had multiple osteoporotic compression fractures. When the spine was bent, the patient complained about a sharp pain in the left mid-axillary line and radiating pain toward the abdomen. On physical examination, the 10(th) rib was not felt, and an image of the rib-cage confirmed that the left 10(th) rib was severed. When applying pressure from the legs to the 9(th) rib of the patient, pain was reproduced. Therefore, the patient was diagnosed with 9(th) rib syndrome, and ultrasound-guided 9(th) and 10(th) intercostal nerve blocks were performed around the tips of the severed 10(th) rib. In addition, local anesthetics with triamcinolone were administered into the muscles beneath the 9(th) rib at the point of the greatest tenderness. The patient's pain was reduced to NRS 2 point. In this case, it is suspected that the patient had a partial resection of the left 10(th) rib in the past, and subsequent compression fractures at T8 and T9 led to the deformation of the rib cage, causing the tip of the remaining 10(th) rib to impinge on the 9(th) intercostal nerves, causing pain.

9th International Workshop on Parallel Tools for High Performance Computing

CERN Document Server

Hilbrich, Tobias; Niethammer, Christoph; Gracia, José; Nagel, Wolfgang; Resch, Michael

2016-01-01

High Performance Computing (HPC) remains a driver that offers huge potentials and benefits for science and society. However, a profound understanding of the computational matters and specialized software is needed to arrive at effective and efficient simulations. Dedicated software tools are important parts of the HPC software landscape, and support application developers. Even though a tool is by definition not a part of an application, but rather a supplemental piece of software, it can make a fundamental difference during the development of an application. Such tools aid application developers in the context of debugging, performance analysis, and code optimization, and therefore make a major contribution to the development of robust and efficient parallel software. This book introduces a selection of the tools presented and discussed at the 9th International Parallel Tools Workshop held in Dresden, Germany, September 2-3, 2015, which offered an established forum for discussing the latest advances in paral...

Preliminary results on σZ and τint fluctuations as a function of incident energy in dissipative heavy ion collisions

International Nuclear Information System (INIS)

Berceanu, I.; Andronic, A.; Duma, M.

1998-01-01

Non-statistical fluctuations in the excitation functions (EF) of dissipative heavy ion collisions (DHIC) was rather unexpected due to the fact that cross sections are always obtained on a 'coarse cell' of TKEL and θ cm . The contribution of a large number of microchannels, N, is expected to attenuate the amplitude of such fluctuations as σ(E) has a χ 2 distribution with 2N degrees of freedom. In the framework of the Partially Overlapping Molecular Levels the observation of the fluctuations of the cross section as a function of the incident energy is explained by the fact that the levels of the dinuclear system formed in the first stage of a dissipative process are excited in a region of low density situated in the vicinity of the yrast line. The time evolution of dinuclear (DNS) system with different mass asymmetries with the total mass of the nuclear system 19 F + 27 Al system configuration and its time evolution, the excitation function for this system has been measured between 111.4 MeV and 136.9 MeV with a 250 keV energy step. Fluctuations with amplitude larger than the statistical errors were observed. Large Z and angular cross correlation coefficients show their nonstatistical nature. An average energy correlation width of 170±65 keV, to which corresponds a DNS lifetime τ int (3.9 ± 1.1)·10 -21 s, was obtained by the energy autocorrelation function (EAF). The experimental EAF secondary structure period agrees with that predicted by Kun model when the deformation of the outgoing fragments is taken into account. To get more insight in the reaction mechanism, the dependence of the charge distribution variance for two total kinetic energy loss windows, W1 = 20 ± 2.5 and W2 = 30 ± 2.5 MeV, was obtained as a function of E lab . The second moments of the experimental charge distributions have been calculated and the obtained values were represented for W1 and W2. Fluctuations with quite large amplitude are present. In a transport approach of deep inelastic

1st Global Conference on Biomedical Engineering & 9th Asian-Pacific Conference on Medical and Biological Engineering

CERN Document Server

Wang, Shyh-Hau; Yeh, Ming-Long

2015-01-01

This volume presents the proceedings of the 9th Asian-Pacific Conference on Medical and Biological Engineering (APCMBE 2014). The proceedings address a broad spectrum of topics from Bioengineering and Biomedicine, like Biomaterials, Artificial Organs, Tissue Engineering, Nanobiotechnology and Nanomedicine, Biomedical Imaging, Bio MEMS, Biosignal Processing, Digital Medicine, BME Education. It helps medical and biological engineering professionals to interact and exchange their ideas and experiences.

Abstracts of the communications presented during the 6th World Rabbit Congress: REPRODUCTION & REPRODUCTION PHYSIOLOGY. Toulouse, July 9-12, 1996

OpenAIRE

REPRODUCTION & REPRODUCTION PHYSIOLOGY

1996-01-01

Abstract not available. REPRODUCTION & REPRODUCTION PHYSIOLOGY (1996). Abstracts of the communications presented during the 6th World Rabbit Congress: REPRODUCTION & REPRODUCTION PHYSIOLOGY. Toulouse, July 9-12, 1996. World Rabbit Science. 58-67. doi:10.4995/wrs.1996.302 58 67 04

IntCal04 terrestrial radiocarbon age calibration, 0-26 cal kyr BP

NARCIS (Netherlands)

Reimer, Paula J.; Baillie, Mike G.L.; Bard, Edouard; Bayliss, Alex; Beck, J. Warren; Bertrand, Chanda J.H.; Blackwell, Paul G.; Buck, Caitlin E.; Burr, George S.; Cutler, Kirsten B.; Damon, Paul E.; Edwards, R. Lawrence; Fairbanks, Richard G.; Friedrich, Michael; Guilderson, Thomas P.; Hogg, Alan G.; Hughen, Konrad A.; Kromer, Bernd; McCormac, Gerry; Manning, Sturt; Bronk Ramsey, Christopher; Reimer, Ron W.; Remmele, Sabine; Southon, John R.; Stuiver, Minze; Talamo, Sahra; Taylor, F.W.; Plicht, Johannes van der; Weyhenmeyer, Constanze E.

2004-01-01

A new calibration curve for the conversion of radiocarbon ages to calibrated (cal) ages has been constructed and internationally ratified to replace IntCal98, which extended from 0–24 cal kyr BP (Before Present, 0 cal BP = AD 1950). The new calibration data set for terrestrial samples extends from

CRISPR-Cas9 mediated genetic engineering for the purification of the endogenous integrator complex from mammalian cells.

Science.gov (United States)

Baillat, David; Russell, William K; Wagner, Eric J

2016-12-01

The Integrator Complex (INT) is a large multi-subunit protein complex, containing at least 14 subunits and a host of associated factors. These protein components have been established through pulldowns of overexpressed epitope tagged subunits or by using antibodies raised against specific subunits. Here, we utilize CRISPR/Cas9 gene editing technology to introduce N-terminal FLAG epitope tags into the endogenous genes that encode Integrator subunit 4 and 11 within HEK293T cells. We provide specific details regarding design, approaches for facile screening, and our observed frequency of successful recombination. Finally, using silver staining, Western blotting and LC-MS/MS we compare the components of INT of purifications from CRISPR derived lines to 293T cells overexpressing FLAG-INTS11 to define a highly resolved constituency of mammalian INT. Copyright © 2016 Elsevier Inc. All rights reserved.

Royal Decree No. 1116/1984 dated 9th May 1984, in respect of restoration of land affected by opencast mining operations. [Spain

Energy Technology Data Exchange (ETDEWEB)

1984-01-01

Of the set of norms relating to protection of the environment, which have come into force in Spain within the last few years, Royal Decree No. 1116/1984 of 9th May, 1984, and the Order from the Ministry of Industry and Energy dated 13th June 1984, which is complementary to it, are worth special mention in the field of mining. They both cover the restoration of open spaces affected by opencast mining operations.

Campylobacter jejuni induces diverse kinetics and profiles of cytokine genes in INT-407 cells

International Nuclear Information System (INIS)

Al-Amri, Ahlam I.; Bakhiet, Moiz O.; Botta, Giuseppe A.; Tabbara, Khaled S.; Ismaeel, Abdelrahman Y.; Al-Mahmeed, Ali E.; Bin Danya, Khalid M.

2008-01-01

Objective was to examine the kinetic ability of embryonic human epithelial INT-407 cells to express messenger ribonucleic acid (mRNA) for various cytokines and chemokines in response to Campylobacter jejuni (C. jejuni) stimulation. In an experimental single-blind study, cultured embryonic human epithelial INT-407 cells were treated with different concentrations of viable C. jejuni, its sonicated and filtered supernatant. A modified non-radioactive in situ hybridization using probe cocktails was used to measure mRNA levels for the pro-inflammatory cytokines interleukin (IL)-1beta, IL-6, interferon-gamma, tumor necrosis factor (TNF)-alpha, transforming growth factor (TGF)-beta1 and IL-8 and the anti-inflammatory cytokines, IL-4 and IL-10. The study was carried out from September 2005 to March 2007 at the Department of Microbiology, Immunology and Infectious Diseases, College of Medicine and Medical Sciences, Arabian Gulf University, Bahrain. Viable C. jejuni sonicated bacteria and filtered supernatant induced high mRNA expression for the pro-inflammatory cytokines IL-1 beta, IL-6, IFN-gama, TNF-alpha, TGF-beta and IL-8 which peaked at the 12 hours post stimulation. Anti-inflammatory cytokine IL-4 and IL-10 mNRA expression were induced maximally at 3 hours post stimulation mainly by sonicated bacteria and filtrated supernatant, however, not with living bacteria and filtrated supernatant, however, not with living bacteria. Untreated embryonic human epithelial INT-407 cells expressed low amount of mNRA for the various cytokines and chemokines at all time points. For each cytokine, 4 samples were used per time hour. This study demonstrated that embryonic human epithelial INT-407 cells in response to viable C. jejuni or its cytotxins can alter cytokine and chemokine mNRA expression patterns and kinetics suggesting a potential role for these mediators in the immunopathogenesis of the infection caused by this pathogen, which might be relevant for future immunotherapeutic

Comparative Analysis of Indicators of Coordination Abilities Development in 5th-7th Graders

Directory of Open Access Journals (Sweden)

В. В. Приходько

2017-09-01

Full Text Available The objective of the research is to determine the regularities of coordination abilities development in 5th-7th-grade boys.  Materials and methods. The participants in the research were boys of the 5th grade (n = 21, 6th grade (n = 20, 7th grade (n = 19. To achieve the tasks outlined, the research used the following methods: analysis of scientific and methodological literature; pedagogical testing, pedagogical observation, methods of mathematical statistics. Research results. The 5th-6th-grade boys show a statistically significant difference between their results in the following tests: “Standing long jump (cm” (p < 0.002; “Six standing accuracy ball handlings to a partner from a 7 m distance using one of the techniques learned” (p < 0.049; “Rhythmic hand tapping” (p < 0.044; “Rhythmic movements of upper and lower limbs” (p < 0.042 (p < 0.05; “Height (cm”; “Body weight (kg”. The 6th-7th-grade boys — “30 m running (s”; “Standing long jump (cm”; “Sit-ups in 30 seconds”; “Evaluation of static equilibrium by E. Ya. Bondarevsky’s method”; “Evaluation of dynamic equilibrium by the BESS method”; “Rhythmic hand tapping”; “Rhythmic movements of upper and lower limbs”; “Shuttle run (4 × 9 m”; “Tossing rings over a peg”. The 5th-7th-grade boys — “Standing long jump (cm”; “Pull-ups (number of times”; “Evaluation of the ability to differentiate movement speed (accuracy in reproduction of running speed, 90% of maximum”; “Evaluation of static equilibrium by E. Ya. Bondarevsky’s method”; “Evaluation of dynamic equilibrium by the BESS method”; “Rhythmic hand tapping”; “Shuttle run (4 × 9 m”; “Height (cm”; “Body weight (kg”. Conclusions. The research has observed a positive dynamics of the results in the following group of tests: “Standing long jump” by 8.4%, “Rhythmic hand tapping and rhythmic movements of upper and lower

Théorie du compromis versus Théorie du financement hiérarchique : une analyse sur un panel de PME non cotées

OpenAIRE

Adair, Philippe

2014-01-01

International audience; Résumé Nous testons les hypothèses relatives aux théories de la structure financière-compromis et financement hiérarchique-au regard de la fiscalité, des coûts d'agence et de l'asymétrie d'information. La variable expliquée est le taux d'endettement financier grâce à un modèle linéaire sur un panel cylindré de 2370 PME françaises observées durant la période 2002-2010. Selon nos résultats, à l'exception des garanties qui conditionnent l'accès au crédit et le crédit inte...

Blockade of αEβ7 integrin suppresses accumulation of CD8+ and Th9 lymphocytes from patients with IBD in the inflamed gut in vivo.

Science.gov (United States)

Zundler, Sebastian; Schillinger, Daniela; Fischer, Anika; Atreya, Raja; López-Posadas, Rocío; Watson, Alastair; Neufert, Clemens; Atreya, Imke; Neurath, Markus F

2017-11-01

Therapeutically targeting lymphocyte adhesion is of increasing relevance in IBD. Yet, central aspects of the action of antiadhesion compounds are incompletely understood. We investigated the role of αEβ7 and α4β7 integrins and their blockade by vedolizumab and etrolizumab for trafficking of IBD T lymphocytes in an in vivo model of homing to and retention in the inflamed gut. We explored integrin expression in patients with IBD by flow cytometry and immunohistochemistry, while regulation of integrins was studied in T cell cultures. The functional relevance of integrins was assessed by adhesion assays and a recently established humanised mouse model in dextran sodium sulfate-treated immunodeficient mice. High expression of αEβ7 was noted on CD8 + and CD4 + Th9 cells, while α4β7 was expressed on CD8 + , Th2 and Th17 cells. T cell receptor stimulation and transforming growth factor β were key inducers of αEβ7 on human T cells, while butyric acid suppressed αEβ7. In comparison to α4β7 blockade via vedolizumab, blockade of β7 via etrolizumab surrogate antibody superiorly reduced colonic numbers of CD8 + and Th9 cells in vivo after 3 hours, while no difference was noted after 0.5 hours. AEβ7 expression was higher on CD8 + T cells from patients with IBD under vedolizumab therapy. AEβ7 is of key relevance for gut trafficking of IBD CD8 + T cells and CD4 + Th9 cells in vivo and mainly retention might account for this effect. These findings indicate that blockade of αEβ7 in addition to α4β7 may be particularly effective in intestinal disorders with expansion of CD8 + and Th9 cells such as IBD. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

The 9th International Countercurrent Chromatography Conference held at Dominican University, Chicago, USA, August 1-3, 2016.

Science.gov (United States)

Friesen, J Brent; McAlpine, James B; Chen, Shao-Nong; Pauli, Guido F

2017-10-20

The 9th International Countercurrent Chromatography Conference (CCC 2016) was held at Dominican University near Chicago, IL (USA), from August 1st-3rd, 2016. The biennial CCC 20XX conferences provide an opportunity for countercurrent chromatography and centrifugal partition chromatography (CCC/CPC) manufactures, marketers, theorists, and research scientists to gather together socially, learn from each other, and advance countercurrent separation technology. A synopsis of the conference proceedings as well as a series of short reviews of the special edition articles is included in this document. Many productive discussions and collegial conversation at CCC 2016 attested to the liveliness, connectivity, and productivity of the global countercurrent research community and bodes well for the success of the 10th conference at the University of Braunschweig, Germany on August 1-3, 2018. Copyright © 2017 Elsevier B.V. All rights reserved.

Climate Change, Risks and Natural Resources didactic issues of educational content geography of Bulgaria and the world in 9th and 10th grade

Science.gov (United States)

Dermendzhieva, Stela; Nejdet, Semra

2017-03-01

The purpose of this paper is to follow "Climate change, risks and Natural Resources" in the curriculum of Geography of Bulgaria and the world in 9th and 10th grade and to interpret some didactic aspects. Analysis of key themes, concepts and categories related to the environment, events and approaches to environmental protection and the environmentally sound development of sectors of the economy is didikticheski targeted. Considering the emergence and development of geo-ecological issues, their scope and their importance to the environment, systematize some species and some approaches to solving them. Geography education in grade 9 and 10 involves acquiring knowledge, developing skills and composing behaviors of objective perception and assessment of the reality of globed, regional and local aspect. The emerging consumer and individualistic culture snowballing globalization, are increasingly occurring global warming, declining biodiversity form new realities which education must respond appropriately. The objective, consistency, accessibility and relevance in real terms are meaningful, logical accents. Whether and how reproduced in the study of Geography of Bulgaria and the world is the subject of research study in this report. Geoecological structuring of topics, concepts and categories can be done in different signs. In terms of their scope are local, national or regional, and global. Matter and interdisciplinary approach, which is to reveal the unity of the "man-society-nature" to clarify the complexity of their character with a view to forming a harmonious personality with high Geoecological consciousness and culture, and the activities carried out in their study.

The 9th Grade Shock and the High School Dropout Crisis

Science.gov (United States)

Pharris-Ciurej, Nikolas; Hirschman, Charles; Willhoft, Joseph

2011-01-01

Retrospective questions on educational attainment in national surveys and censuses tend to over-estimate high school graduation rates by 15 to 20 percentage points relative to administrative records. Administrative data on educational enrollment are, however, only available at the aggregate level (state, school district, and school levels) and the recording of inter-school transfers are generally incomplete. With access to linked individual-level administrative records from a very large “West Coast metropolitan school district” we track patterns of high school attrition and on-time high school graduation of individual students. Even with adjustments for the omission of out-of-district transfers (estimates of omission are presented), the results of this study show that failure in high school, as indexed by retention and attrition, are almost as common as on-time high school graduation. In addition to the usual risk factors of disadvantaged background, we find that the “9th grade shock”—an unpredicted decline in academic performance upon entering high school—is a key mechanism behind the continuing crisis of high school attrition. PMID:23017804

Public health and social supervision issues within public administration of ukrainian territories in the late 8th- early 9th centuries.

Science.gov (United States)

Hrynzovskyi, Anatolii M; Holovanova, Irina A; Omelchuk, Sergei T; Kuzminska, Olena V; Hrynzovska, Anastasia A; Karlova, Olena O; Kondratiuk, Vitalii Ye

Introduction: The public health system modernization history is based upon the progress in state country administration and administration of healthcare within the sectorwide approach. The WHO European Bureau pays much attention to the National Health Service systems development while implementing their basic policies. The Ukrainian state health service management was founded basing on the regulatory field of the Russian Empire, using the European healthcare promotion experience. Aim: of the article is the analysis of the regulatory field of police and amenity authorities of the Russian Empire and Ukraine within the medical and social service in the 18th-19th centuries. Materials and methods: The structure of the article corresponds to the problem city and chronology principles, using the following methods and techniques of scientific learning: the systemic, historic, regulatory comparative, logical and structural-functional analysis of the studied medical-legal phenomena. The study sources are the scientific publications, collections of laws and executive orders of the Russian Empire and Ukraine in the 18th-19th centuries. Review: As a result of the performed work it can be determined were the main directions of the police competence in late 18th- early 19th centuries. Conclusion: Preserving health, treatment of the ill and injured, management of medical and social service of those in need, holding various preventive activities and supporting safe environment and regulating the safety of food were the main directions of the police competence in late 18th- early 19th centuries.

ISMIR 2010 Proceedings of the 11th International Society for Music Information Retrieval Conference, August 9-13, 2010 Utrecht, Netherlands

NARCIS (Netherlands)

Downie, J. Stephen; Veltkamp, Remco C.

2010-01-01

Welcome to the 11th International Society for Music Information Retrieval Conference (ISMIR 2010). ISMIR 2010 will be convened in Utrecht, Netherlands, 9-13 August 2010 and is jointly organised by Utrecht University, the Utrecht School of the Arts, the Meertens Institute and Philips Research. The

L’innovation sociale et l’entrepreneur schumpétérien : deux lectures théoriques

Directory of Open Access Journals (Sweden)

Dennis Harrisson

2012-05-01

Full Text Available Le rôle de l’entrepreneur est fondamental dans la théorie de l’innovation conçue par Schumpeter. Toutefois, le concept d’entrepreneur est toujours un sujet de controverse. D’une part, il ne semble pas guidé par un intérêt égoïste tel que le proposent les tenants de la théorie du choix rationnel; d’autre part, il n’est pas non plus contraint entièrement par les barrières institutionnelles selon les préceptes de la théorie institutionnaliste. L’entrepreneur est capable de lever les obstacles afin d’innover. Dans cet article, nous traitons de la place de l’entrepreneur dans la conception de l’innovation sociale. Les connaissances développées sur le processus d’innovation sont complétées par des avancées dans la théorie du choix rationnel et dans la théorie institutionnaliste. Ainsi, le rôle de l’entrepreneur est mieux compris comme étant l’objet d’une tension entre l’intérêt individuel et le bien commun.The entrepreneur's role is fundamental in the theory of innovation devised by Schumpeter. However, the concept of entrepreneur is still controversial. On the one hand, it does not seem guided by an egoistic interest as proposed by the advocates of rational choice theory, and secondly, it is not entirely constrained across institutional boundaries according to the principles of institutionalist theory. The entrepreneur is able to remove barriers to innovation. In this paper, we discuss the role of the entrepreneur in the development of social innovation. The knowledge acquired in the innovation process are complemented by advances in the rational choice theory of and the institutionalist theory. Thus, the role of the entrepreneur is better understood as being subject to a tension between individual interest and common good.

Actualizing of calibration curves of "1"4C/C, "9"0Sr/Ca, "2"2"8Th/"2"3"2Th in ivory for the determination of the post mortal interval of elephants and consequences of the radiation protection of non-human species

International Nuclear Information System (INIS)

Schupfner, R.

2016-01-01

The determination of the activity concentration of the radionuclides "1"4C/C and "9"0Sr/Ca and "2"2"8Th/"2"3"2Th applying combined radionuclide analyses methods has been proved to be a suitable tool for the purpose of an unambiguous age determination of elephant ivory [1, 2, 3, 10, 11, 12, 13]. Analysing representative and independently dated samples (N = 28) of ivory the curves fitting the post mortal interval (PMI) versus the activity concentration of the radionuclides mentioned above produced the data base enabling a more unambiguous age determination. Data from these studies origin [1, 2, 3, 10, 11, 12, 13] in analyses of ivory samples which were available up to the 2012. During the last five years there was a gap in information of the future trend of "1"4C/C and "9"0Sr/Ca. Up to this study it was not possible to assess whether the future level of "1"4C/C as well as "9"0Sr/Ca can analytically be distinguished from the level before 1954. At about 1954 the activity concentration of radionuclides from the atmospheric nuclear explosion, as "1"4C and "9"0Sr, increased in ivory significantly. This study aims in closing this information gap. The results of analyses of "1"4C/C, "9"0Sr/Ca, "2"2"8Th/"2"3"2Th in ivory with PMI values ranging from 1 to 5 years are presented and interpreted. These data enable an actualization of the calibration curves of PMI versus specific activities. This is necessary for a better understanding of the effect of blindness of "1"4C/C dating and its prevention. On the base of all available results form independent dated ivory sample available up to 2015 a suitable analytical procedure is suggested which aims in a more precise and reliable age determination of elephant tusks. Results of determining of radionuclides "1"4C/C and "9"0Sr/Ca and "2"2"8Th/"2"3"2Th in ivory are shown from before 1950 to 2015. These results are discussed with respect the purposes of dating as well as their significance to the radiation protection of nonhuman species.

Le besoin de réassurance : de la psychologie au comportement du consommateur Une investigation théorique appliquée au cas de la consommation alimentaire moderne

Directory of Open Access Journals (Sweden)

Wejdene Yanhui

2015-03-01

Ce travail, dont l’intérêt est essentiellement théorique, s’inscrit parmi les travaux rares introduisant le besoin de réassurance dans l’étude du comportement du consommateur. Des travaux futurs peuvent se baser sur cette conceptualisation pour identifier les déterminants de ce besoin.

IL-9 antibody injection suppresses the inflammation in colitis mice

Energy Technology Data Exchange (ETDEWEB)

Yuan, Aping [Laboratory of Molecular Cell Biology, Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås (Norway); Research Group of Gastrointestinal Diseases, The Second Affiliated Hospital of Zhengzhou University, Henan (China); Yang, Hang; Qi, Haili; Cui, Jing; Hua, Wei; Li, Can; Pang, Zhigang; Zheng, Wei [Research Group of Gastrointestinal Diseases, The Second Affiliated Hospital of Zhengzhou University, Henan (China); Cui, Guanglin, E-mail: guanglin.cui@yahoo.com [Research Group of Gastrointestinal Diseases, The Second Affiliated Hospital of Zhengzhou University, Henan (China); Faculty of Health, Nord University at Levanger (Norway)

2015-12-25

Diverse T help (Th) cells play a crucial role in the processing and maintaining of chronic inflammation as seen in ulcerative colitis (UC). Th9, a novel subset of Th cells that primarily produces interleukin (IL)-9, has recently been associated with the development of inflammatory diseases. In this study, we evaluated the presentation of Th9 cells in inflamed tissues of human and experimental mouse UC, and examined the therapeutic efficiency of anti Th9 cytokine IL-9 in the experimental mouse UC. Using immunohistochemistry (IHC), we evaluated the presentation of Th9 cells labelled by transcriptional factor PU.1 in both human and dextran sulfate sodium (DSS) induced mouse colitis biopsies. The results showed that increased PU.1 positive Th9 cells were mainly located in the lamina propria in relative with the controls, intraepithelial Th9 cells can also be observed but at low density. Double IHCs revealed that most of PU.1 positive cells were CD3 positive lymphocytes in human UC specimens. Anti-IL-9 antibody injection for 2 weeks reduced the severity of inflammation in DSS induced colitis mice. Our results suggest that The Th9/IL-9 is involved in the pathogenesis of UC. - Highlights: • The density of novel PU.1 positive Th9 cells is significantly increased in both human and mouse colitis tissues. • PU.1 positive Th9 cells are predominately located in the inflamed lamina propria in both human and mouse colitis tissues. • Blocking of Th9 cytokine IL-9 by antibody injection suppresses the severity of inflammation in the bowel in colitis mice. • Novel Th9 cells contribute to the pathogenesis of UC.

IL-9 antibody injection suppresses the inflammation in colitis mice

International Nuclear Information System (INIS)

Yuan, Aping; Yang, Hang; Qi, Haili; Cui, Jing; Hua, Wei; Li, Can; Pang, Zhigang; Zheng, Wei; Cui, Guanglin

2015-01-01

Diverse T help (Th) cells play a crucial role in the processing and maintaining of chronic inflammation as seen in ulcerative colitis (UC). Th9, a novel subset of Th cells that primarily produces interleukin (IL)-9, has recently been associated with the development of inflammatory diseases. In this study, we evaluated the presentation of Th9 cells in inflamed tissues of human and experimental mouse UC, and examined the therapeutic efficiency of anti Th9 cytokine IL-9 in the experimental mouse UC. Using immunohistochemistry (IHC), we evaluated the presentation of Th9 cells labelled by transcriptional factor PU.1 in both human and dextran sulfate sodium (DSS) induced mouse colitis biopsies. The results showed that increased PU.1 positive Th9 cells were mainly located in the lamina propria in relative with the controls, intraepithelial Th9 cells can also be observed but at low density. Double IHCs revealed that most of PU.1 positive cells were CD3 positive lymphocytes in human UC specimens. Anti-IL-9 antibody injection for 2 weeks reduced the severity of inflammation in DSS induced colitis mice. Our results suggest that The Th9/IL-9 is involved in the pathogenesis of UC. - Highlights: • The density of novel PU.1 positive Th9 cells is significantly increased in both human and mouse colitis tissues. • PU.1 positive Th9 cells are predominately located in the inflamed lamina propria in both human and mouse colitis tissues. • Blocking of Th9 cytokine IL-9 by antibody injection suppresses the severity of inflammation in the bowel in colitis mice. • Novel Th9 cells contribute to the pathogenesis of UC.

9{sup th} international workshop on large-scale integration of wind power into power systems as well as on transmission networks for offshore wind power plants. Proceedings

Energy Technology Data Exchange (ETDEWEB)

Betancourt, Uta; Ackermann, Thomas (eds.)

2010-07-01

Within the 9th International Workshop on large-scale integration of wind power into power systems as well as on transmission networks for offshore wind power plants at 18th to 19th October, 2010 in Quebec (Canada), lectures and poster papers were presented to the following themes: (1) Keynote session and panel; (2) European grid integration studies; (3) Modeling; (4) Wind forecasting; (5) North American grid integration studies; (6) Voltage stability and control; (7) Grid codes and impact studies; (8) Canadian University research (WESNet); (9) Operation and dispatch; (9) Offshore wind power plants; (10) Frequency Control; (11) Methodologies to estimate wind power impacts on power systems, summaries from IEAWIND collaboration; (12) HVDC; (13) Grid codes and system impact studies; (14) Modeling and validation; (15) Regulations, markets and offshore wind energy; (16) Integration issues; (17) Wind turbine control system; (18) Energy management and IT solutions.

"Shakespeare Revisited" : Théâtre et métathéâtre dans les comédies de Thomas Kilroy

OpenAIRE

Logez-Carpentier, Godeleine

2017-01-01

L'œuvre de Kilroy, qui se démarque nettement de la traditon théâtrale réaliste irlandaise longtemps représentée par l'Abbey Theatre, frappe avant tout par sa modernité et son originalité scénique. Si les thèmes de ses pièces restent les mêmes que ceux abordés par les dramaturges de l'Abbaye, leur traitement est cependant radicalement différent, intégrant les bouleversements sociaux, économiques, culturels et spirituels qui caractérisent l'Irlande de la seconde moitié du XXème siècle. A une ap...

The combination of maltose-binding protein and BCG-induced Th1 activation is involved in TLR2/9-mediated upregulation of MyD88-TRAF6 and TLR4-mediated downregulation of TRIF-TRAF3.

Science.gov (United States)

Liu, Guomu; Zhai, Xiaoyu; Zhou, Hongyue; Yang, Xiaoyu; Zhang, Nannan; Tai, Guixiang; Ni, Weihua

2018-03-01

Our previous study demonstrated that maltose-binding protein (MBP) activated Th1 through the TLR2-mediated MyD88-dependent pathway and the TLR4-mediated TRIF-dependent pathway. The combination of MBP and BCG synergistically induced Th1 activation, and the TLR2/9-mediated MyD88-dependent pathway is involved in this process. To further explore this mechanism, we stimulated purified mouse CD4 + T cells with MBP and BCG in vitro. The results demonstrated that MBP combined with BCG synergistically increased IFN-γ production and TLR2/4/9 expression, suggesting the involvement of TLR2/4/9 in the combination-induced Th1 activation. Next, TLRs 2/4/9 were blocked to analyze the effects of TLRs on Th1 activation. The results demonstrated that MBP induced a low level of Th1 activation by upregulating TLR2-mediated MyD88-TRAF6 and TLR4-mediated TRIF-TRAF3 expression, whereas MBP combined with BCG induced synergistic Th1 activation, which was not only triggered by strong upregulation of TLR2/9-mediated MyD88-TRAF6 expression but also by shifting TLR4-mediated TRIF-TRAF3 into the TRIF-TRAF6 pathway. Moreover, we observed that a TLR4 antibody upregulated MyD88 expression and a TLR9 inhibitor downregulated TRIF expression, indicating that there was cross-talk between TLRs 2/4/9 in MBP combined with BCG-induced Th1 activation. Our findings may expand the knowledge regarding TLR cross-talk involved in regulating the Th1 response. Copyright © 2018 Elsevier Inc. All rights reserved.

Exon sequence requirements for excision in vivo of the bacterial group II intron RmInt1

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Toro Nicolás

2011-05-01

Full Text Available Abstract Background Group II intron splicing proceeds through two sequential transesterification reactions in which the 5' and 3'-exons are joined together and the lariat intron is released. The intron-encoded protein (IEP assists the splicing of the intron in vivo and remains bound to the excised intron lariat RNA in a ribonucleoprotein particle (RNP that promotes intron mobility. Exon recognition occurs through base-pairing interactions between two guide sequences on the ribozyme domain dI known as EBS1 and EBS2 and two stretches of sequence known as IBS1 and IBS2 on the 5' exon, whereas the 3' exon is recognized through interaction with the sequence immediately upstream from EBS1 [(δ-δ' interaction (subgroup IIA] or with a nucleotide [(EBS3-IBS3 interaction (subgroup IIB and IIC] located in the coordination-loop of dI. The δ nucleotide is involved in base pairing with another intron residue (δ' in subgroup IIB introns and this interaction facilitates base pairing between the 5' exon and the intron. Results In this study, we investigated nucleotide requirements in the distal 5'- and 3' exon regions, EBS-IBS interactions and δ-δ' pairing for excision of the group IIB intron RmInt1 in vivo. We found that the EBS1-IBS1 interaction was required and sufficient for RmInt1 excision. In addition, we provide evidence for the occurrence of canonical δ-δ' pairing and its importance for the intron excision in vivo. Conclusions The excision in vivo of the RmInt1 intron is a favored process, with very few constraints for sequence recognition in both the 5' and 3'-exons. Our results contribute to understand how group II introns spread in nature, and might facilitate the use of RmInt1 in gene targeting.

The Use of Monograms on Byzantine Seals in the Early Middle-Ages (6th to 9th Centuries

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Werner Seibt

2016-06-01

Full Text Available The paper deals especially with monograms on Byzantine lead seals. The early form was the block monogram, a type used already in Classical times, which came into fashion in the Byzantine world in the 6th or already in the 5th century and remained important till the early 7th century. Such monograms hide normally a name, a title or an office, the Greek ones in genitive, the Latin ones in nominative or genitive. Many of them can be read in different ways. For the double using of parts of letters for other ones the well-known Latin monogram of Theoderich is explained in detail.  But the “typical Byzantine monogram” became the cross monogram, with letters more or less affixed on the arms of a Greek cross. The earliest example stems from a coin of Justinus I, starting 522, quite earlier than Theodora’s monograms on capitals in the Hagia Sophia. These cruciform monograms presented in the beginning also a name, a title or an office, but in the 8th century already often a combination of them; these monograms with prosopographical information stopped in Byzantium at the end of the 8th century.  On the other hand invocative monograms (like Θεοτόκε βοήθει, often with the tetragram τῷ σῷ δούλῳ in the free quarters of the monogram, started around the middle of the 7th century and can be found till the earlier 11th century. The most common ones were collected by V. Laurent – we use this system till today, though there are much more types documented.  An important problem is that sometimes single letters are “hidden” in another letter, e. g. Lambda in Alpha or Delta, Epsilon in a Kappa on the left bar of a cross monogram, Sigma in Epsilon, Sigma in Kappa, Omikron in Rho, etc. In Vienna we developed a special program to solve many monograms. If we bring all the readable letters of a monogram (including the possibly additional ones in an alphabetical order, and do the same with the letters of names, titles and offices

Cytokines in systemic lupus erythematosus: far beyond Th1/Th2 dualism lupus: cytokine profiles.

Science.gov (United States)

Guimarães, Poliana Macedo; Scavuzzi, Bruna Miglioranza; Stadtlober, Nicole Perugini; Franchi Santos, Lorena Flor da Rosa; Lozovoy, Marcell Alysson Batisti; Iriyoda, Tatiana Mayumi Veiga; Costa, Neide Tomimura; Reiche, Edna Maria Vissoci; Maes, Michael; Dichi, Isaias; Simão, Andréa Name Colado

2017-10-01

The aims of this study were to delineate cytokine profiles of systemic lupus erythematosus (SLE), construct prediction models for diagnosis and disease activity using those profiles, and to examine the associations between TNFB Ncol polymorphism, body mass index (BMI) and vitamin D levels with cytokine levels. Two hundred SLE patients and 196 healthy controls participated in this case-control study. Plasma cytokines levels of tumor necrosis factor (TNF)-α, interferon (IFN)-γ, interleukin (IL)-1β, IL- 4, IL-6, IL-10, IL-12 and IL-17 were measured and cytokines profiles were computed. IL-6, IL-12, IL-17, IFN-γ and IL-10 levels were significantly higher in SLE, while IL-4 was lower in SLE. The Th1/Th2 and Th1+Th17/Th2 profiles were significantly higher in SLE than in healthy controls, whereas there were no significant differences in the proinflammatory cytokine profile (TNFα+IL-6+IL-1β). In total, 90.4% of all subjects were correctly classified using Th1+Th17 profile and IL-10 (positively associated) and IL-4 (negatively associated) as predictor variables (sensitivity=66.7% and specificity=96.9%). In all, 20.9% of the variance in the SLE Disease Activity Index was predicted by the Th1+Th17/Th2 ratio, IL-10 and BMI (all positively) and proinflammatory profile (inversely associated). B1/B1 genotype is accompanied by increased IL-17 and Th17/Th2 ratio, while B1/B2 genotype is accompanied by higher IL-4 and IFNγ values. 25-OH vitamin D was inversely associated with IFN-γ levels. SLE is accompanied by Th1, Th17 and Treg profile and lowered IL-4 production. Lowered vitamin D levels and B1/B1 genotype, but not BMI, contribute to changes in cytokines profiles. Future treatments should target Th1, Th2 and Th17 profiles rather than inflammatory cytokines.

TGF-β converts Th1 cells into Th17 cells through stimulation of Runx1 expression.

Science.gov (United States)

Liu, Hou-Pu; Cao, Anthony T; Feng, Ting; Li, Qingjie; Zhang, Wenbo; Yao, Suxia; Dann, Sara M; Elson, Charles O; Cong, Yingzi

2015-04-01

Differentiated CD4(+) T cells preserve plasticity under various conditions. However, the stability of Th1 cells is unclear, as is whether Th1 cells can convert into Th17 cells and thereby contribute to the generation of IFN-γ(+) IL-17(+) CD4(+) T cells, the number of which correlates with severity of colitis. We investigated whether IFN-γ(+) Th1 cells can convert into Th17 cells under intestinal inflammation and the mechanisms involved. IFN-γ(Thy1.1+) Th1 cells were generated by culturing naïve CD4(+) T cells from IFN-γ(Thy1.1) CBir1 TCR-Tg reporter mice, whose TCR is specific for an immunodominant microbiota antigen, CBir1 flagellin, under Th1 polarizing conditions. IFN-γ(Thy1.1+) Th1 cells induced colitis in Rag(-/-) mice after adoptive transfer and converted into IL-17(+) Th17, but not Foxp3(+) Treg cells in the inflamed intestines. TGF-β and IL-6, but not IL-1β and IL-23, regulated Th1 conversion into Th17 cells. TGF-β induction of transcriptional factor Runx1 is crucial for the conversion, since silencing Runx1 by siRNA inhibited Th1 conversion into Th17 cells. Furthermore, TGF-β enhanced histone H3K9 acetylation but inhibited H3K9 trimethylation of Runx1- and ROR-γt-binding sites on il-17 or rorc gene in Th1 cells. We conclude that Th1 cells convert into Th17 cells under inflammatory conditions in intestines, which is possibly mediated by TGF-β induction of Runx1. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Movement Coordination: Factor Structure of Development in 5th-7th Grade Girls

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O. Ivashchenko

2018-03-01

Full Text Available The study objective is to determine the structure of coordination abilities development in 5th-7th grade girls. Materials and methods. The participants in the study were 5th grade girls (n = 20, 6th grade girls (n = 23, 7th grade girls (n = 19. The study used the following methods: analysis and collation of scientific and methodological literature, general scientific methods of theoretical level, such as analogy, analysis, synthesis, abstraction, induction, as well as general scientific methods of empirical level: observation, testing, experiment. To evaluate motor preparedness, the study recorded the results of motor tests, body height and weight. The IBM SPSS 20 statistical analysis software was used to process the study materials. A factor analysis was performed, for which the study used principal component analysis with the rotation method: Variamax with Kaiser Normalization. Results. The analysis of similarities shows that the most informative tests in the structure of motor preparedness of the 5th grade girls are the following: test 11 “Evaluation of the ability for vestibular (statokinetic stability. Running with turns” (.884, test 9 “Static equilibrium evaluation by E. Ya. Bondarevsky’s method” (.826, test 6 “Evaluation of the sense of movement speed in sprinting” (.824; of the 6th grade girls — test 11 “Evaluation of the ability for vestibular (statokinetic stability. Running with turns” (0.884, test 9 “Static equilibrium evaluation by E. Ya. Bondarevsky’s method” (.826, test 6 “Evaluation of the sense of movement speed in sprinting” (.824; of the 7th grade girls — test 8 “Evaluation of the ability to differentiate movement speed (reproduction accuracy of running speed at 90% intensity of maximum” (.902, test 11 “Evaluation of the ability for vestibular (statokinetic stability. Running with turns” (.900, test 1 “30 m running (s” (.869. Conclusions. In the structure of

La ansiedad escénica en intérpretes musicales chilenos

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Mimí Marinovic

2006-06-01

Full Text Available La ansiedad escénica (AE es uno de los mayores problemas del ejercicio profesional de los intérpretes musicales. Encuestas realizadas en países desarrollados revelan cifras de prevalencia entre 24% -70% y citan casos severos, causantes del abandono de la carrera. Objetivos: detectar la prevalencia de la AE en músicos chilenos que desempeñan su profesión en los principales conjuntos de música de concierto y determinar algunos de los factores que, a su juicio, influyen en su aparición. Método: 249 intérpretes (122 instrumentistas, 26 directores y 101 cantantes respondieron un cuestionario autoaplicado, incluido en una investigación más amplia sobre los intérpretes de arte. Este instrumento fue complementado con 36 entrevistas abiertas (13 instrumentistas, 6 directores y 11 cantantes. Resultados: el 78% de los músicos estudiados admitió haber sufrido AE, más mujeres que varones. El 64% consideró que ella se relaciona principalmente con la tarea a ejecutar (preparación insuficiente, dificultad de la obra, mientras que el 32% lo atribuyó a factores personales (ser nervioso, temor al fracaso y sólo el 4% a factores situacionales. Hubo diferencias significativas por género, especialidad y edad. Las entrevistas permitieron profundizar acerca del alcance de estos resultados. Conclusiones: se constató una alta prevalencia de AE, la cual debiera ser abordada interdisciplinariamente por especialistas de la salud mental y la música en beneficio de la educación general, la formación especializada y el desarrollo profesional de los intérpretes musicalesPerformance anxiety (PA is one of the major problems that musicians face in their careers. Surveys carried out in developed countries show prevalence figures ranging 24% -70% and quote severe cases leading to abandonment of the profession. Objectives: detect the prevalence of PA in Chilean musicians working in the main groups of concert music and determine some of the factors that

An investigation of the relationships between junior high school students' (8th and 9th grades) background variables and structure of knowledge recall of biological content

Science.gov (United States)

Demetrius, Olive Joyce

The purpose of this study was to examine the relationships between Junior High School students' (8th and 9th grades) background variables (e.g. cognitive factors, prior knowledge, preference for science versus non-science activities, formal and informal activities) and structure of information recall of biological content. In addition, this study will illustrate how flow maps, a graphic display, designed to represent the sequential flow and cross linkage of ideas in information recalled by the learner can be used as a tool for analyzing science learning data. The participants (46 junior high school students) were taught a lesson on the human digestive system during which they were shown a model of the human torso. Their pattern of information recall was determined by using an interview technique to elicit their understanding of the functional anatomy of the human digestive system. The taped responses were later transcribed for construction of the flow map. The interview was also used to assess knowledge recall of biological content. The flow map, science interest questionnaire and the cognitive operations (based on content analysis of student's narrative) were used to analyze data from each respondent. This is a case study using individual subjects and interview techniques. The findings of this study are: (1) Based on flow map data higher academic ability students have more networking of ideas than low ability students. (2) A large percentage of 9th grade low ability students intend to pursue science/applied science course work after leaving school but they lack well organized ways of representing science knowledge in memory. (3) Content analysis of the narratives shows that students with more complex ideational networks use higher order cognitive thought processes compared to those with less networking of ideas. If students are to make a successful transition from low academic performance to high academic performance it seems that more emphasis should be placed on

Thobie Jacques, Les Intérêts culturels français dans l’Empire ottoman finissant. L’enseignement laïque et en partenariat, Peeters, Leuven, 2009, 461 p.

Directory of Open Access Journals (Sweden)

Caroline Piquet

2010-09-01

Full Text Available À l’heure où la France cherche à relancer sa politique culturelle au Moyen-Orient avec l’implantation d’universités et de lycées prestigieux, l’ouvrage de Jacques Thobie vient nourrir la réflexion sur le rôle de l’éducation dans les processus d’expansion politique et le jeu des puissances. Jacques Thobie publie ici le complément à sa thèse désormais célèbre, Intérêts et impérialisme français dans l’Empire Ottoman 1895-1914. L’ouvrage n’est que la première partie d’un travail sur l’enseignemen...

Programme intégré de lutte contre le paludisme en Afrique ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le paludisme demeure le plus grand facteur de morbidité et de mortalité dans ... sur le système de santé (diagnostic, gestion et prévention des cas), de mesures ... la recherche visant à comprendre la dynamique sociétale et environnementale ... Rapport technique final Écosanté / le contrôle intégré du paludisme basé sur ...

U and Th background contents in the Crimea rocks, Th/U ratio interpretation

International Nuclear Information System (INIS)

Gerasimov, Yu.G.; Voronova, M.A.; AN Ukrainskoj SSR, Kiev. Inst. Geologicheskikh Nauk)

1981-01-01

Radiogeochemical sampling of rocks in the Crimea is carried out. Analyses for U are made by luminescence method, while for Th by X-ray one. About 1000 samples, characterizing the whole stratigraphical cross section except Pz of crystalline rocks, have been analyzed. Low background values for U and Th are established; U content of 1.3-2.3 g/kg and Th content of 7.0-9.0 g/kg are predominant, that is lower than the clark of the earth crust. The distribution of radioelements in stepper and submontane Crimea is gradual, while in mountain part - the mosaic one. Results of Th/U ratios interpretation are presented [ru

L'intégration des plantes médicinales en Inde | IDRC - International ...

International Development Research Centre (IDRC) Digital Library (Canada)

3 févr. 2011 ... Un nouveau programme lancé par le gouvernement de l'Inde pour intégrer les plantes médicinales aux pratiques médicales traditionnelles et aux moyens de subsistance habituels pourrait être une source de revenus pour les villageois qui en font la cueillette et rendre leur utilisation plus sécuritaire.

9th Pacific Basin Nuclear Conference. Nuclear energy, science and technology - Pacific partnership. Proceedings Volume 2

International Nuclear Information System (INIS)

1994-04-01

The theme of the 9th Pacific Basin Nuclear Conference held in Sydney from 1-6 May 1994, embraced the use of atom in energy production and in science and technology. The focus was on selected topics of current and on-going interest to countries around the Pacific Basin. The two-volume proceedings include both invited and contributed papers which have been indexed separately. This document, Volume 2 covers the following topics: education and training in Nuclear Science, public acceptance, nuclear safety and radiation protection, nuclear fuel resources and their utilisation, research reactors, cyclotrons and accelerators. refs., tabs., figs., ills

MetrIntSimil—An Accurate and Robust Metric for Comparison of Similarity in Intelligence of Any Number of Cooperative Multiagent Systems

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Laszlo Barna Iantovics

2018-02-01

Full Text Available Intelligent cooperative multiagent systems are applied for solving a large range of real-life problems, including in domains like biology and healthcare. There are very few metrics able to make an effective measure of the machine intelligence quotient. The most important drawbacks of the designed metrics presented in the scientific literature consist in the limitation in universality, accuracy, and robustness. In this paper, we propose a novel universal metric called MetrIntSimil capable of making an accurate and robust symmetric comparison of the similarity in intelligence of any number of cooperative multiagent systems specialized in difficult problem solving. The universality is an important necessary property based on the large variety of designed intelligent systems. MetrIntSimil makes a comparison by taking into consideration the variability in intelligence in the problem solving of the compared cooperative multiagent systems. It allows a classification of the cooperative multiagent systems based on their similarity in intelligence. A cooperative multiagent system has variability in the problem solving intelligence, and it can manifest lower or higher intelligence in different problem solving tasks. More cooperative multiagent systems with similar intelligence can be included in the same class. For the evaluation of the proposed metric, we conducted a case study for more intelligent cooperative multiagent systems composed of simple computing agents applied for solving the Symmetric Travelling Salesman Problem (STSP that is a class of NP-hard problems. STSP is the problem of finding the shortest Hamiltonian cycle/tour in a weighted undirected graph that does not have loops or multiple edges. The distance between two cities is the same in each opposite direction. Two classes of similar intelligence denoted IntClassA and IntClassB were identified. The experimental results show that the agent belonging to IntClassA intelligence class is less

Intéresser les jeunes à la chose publique | CRDI - Centre de ...

International Development Research Centre (IDRC) Digital Library (Canada)

22 oct. 2010 ... Les gouvernements ont tout intérêt à faire appel à la solidarité naturelle des jeunes en les consultant et en les amenant à participer aux processus de prise ... Dans un pays comme dans l'autre, cependant, les jeunes votent peu, et ce, en dépit du vote obligatoire au Brésil (au risque d'être mis à l'amende) et ...

TH-AB-201-05: Determining the Direction Distribution of the Primary Radiation for a Cyberknife-M6

International Nuclear Information System (INIS)

Henzen, D; Schmidhalter, D; Volken, W; Mackeprang, P-H; Malthaner, M; K Fix, M; Manser, P; C Zanella, C

2016-01-01

Purpose: Radiation protection regulatory differentiates between primary and scatter radiation. Whereas for conventional clinical linear accelerators the solid angle for primary radiation is planar, the Cyberknife (Accuray Inc., Sunnyvale, CA) may point its beam in all spatial directions. In order to be able to judge on radiation protection calculations for a Cyberknife-M6 vault, the direction distribution for delivered plans was evaluated based on clinical experiences. Methods: The log-files of 121 delivered patient treatment plans were exported, divided into cranial and extra-cranial treatments and the delivered monitor units (MU) together with the corresponding beam directions were analyzed. This MU-weighted spatial distribution was then projected to a 9.5 × 5.9 × 3.9 m 3 vault, generating an “intensity map” using a binning of 50 × 50 cm 2 . The factor of direction (FOD) is reported as a fraction of the total applied MUs to the walls, ceiling and floor in the perspective of a patient lying in head-first-supine position on the couch. In this study, the term intFOD refers to the integral FOD and maxFOD refers to the maximal FOD for a single bin. Results: For all kind of treatments and collimators, intFOD and maxFOD for the wall behind the patient’s head is 0.0. The intFOD for the floor varies between 0.65 and 0.74. For the ceiling, maxFOD is 0.002 and 0.0 for cranial and extra-cranial cases, respectively. The intFOD for the wall at the patient’s feet, is 0.094 for cranial and 0.005 for extra-cranial cases. There is nearly no difference between the maxFOD of the right and left wall for cranial cases, whereas for extra-cranial cases these numbers differ by a factor of 1.75. Conclusion: The varying FODs for the Cyberknife were quantified based on delivered treatment plans. These findings are helpful regarding the design of Cyberknife vaults.

Application de la gestion intégrale de l'innovation dans les petites et ...

International Development Research Centre (IDRC) Digital Library (Canada)

'application d'un cadre de gestion intégrale de l'innovation destiné exclusivement aux PME. Les capacités de recherche et de mise en oeuvre seront améliorées au moyen d'une formation aux cycles supérieurs ou d'une autre nature.

Investigation of 9th Grade High School Students’ Attitudes towards Science Course

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Orhan Karamustafaoglu

2017-12-01

Full Text Available In this study, ninth grade students’ attitudes towards science were investigated in terms of self-regulation strategies, motivational beliefs and gender variables. The sample of this study includes 322 male and 296 female in total 618 students from 3 different high schools (Science high school, Anatolian high school, and Vocational high school in center district of Amasya city. To collect the data, the researchers employed “Motivated Strategies for Learning Questionnaire” which has been developed by Pintrich and De Groot in 1990, adapted into Turkish by Uredi in 2005 and consists of 44 items and “Colorado Learning Attitudes about Science Survey (CLASS” has been developed by Adams and others in 2006, adapted into Turkish by Bayar and Karamustafaoğlu in 2015 and consists of 36 items. For data analysis, mean, standard deviation, independent t-test and correlation were addressed. The results of this study show that there are statistically significant relationships between 9th grade students’ attitudes towards science and self-regulation strategies, motivational beliefs, and gender.

Intégration des données de l'atlas des marais atlantiques alimentés en eau de mer dans un système d'information à référence spatiale

OpenAIRE

Loubersac, Lionel; Manaud, Francois; Loarer, Ronan; Kerdreux, Michel; Durand, Christophe

1998-01-01

Ce papier décrit une méthodologie d’intégration des données analogiques d’un Atlas des marais salés atlantiques dans un SIG. On développe les différentes étapes de la méthode après avoir décrit les données originales sources sous forme de cartographie analogique thématique et de textes associés. Ces étapes incluent la digitalisation, les corrections géométriques, la définition d’une typologie et d’attributs, la mise en place de liens entre les graphiques, textes et images, le croisement de co...

Study of a 9th century silver earrings set from Mikulčice: corrosion, conservation and maintenance

OpenAIRE

Cardoso, Mariana Oliveira

2010-01-01

Dissertação apresentada na Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa para obtenção do grau de Mestre em Conservação e Restauro The presented study deal with the degradation processes of the silver objects, buried for a long time in human graves and with their appropriate methods of conservation and restoration after excavation during archaeological research. It was used for this study a set of earrings from the 9th century A.D. found in Mikulčice, in the south...

PREFACE: 9th International Symposium on Cavitation (CAV2015)

Science.gov (United States)

Farhat, M.; Müller, A.

2015-12-01

It is our pleasure and privilege to welcome all the participants of the 9th International Symposium on Cavitation (CAV2015) to Lausanne. Since its initiation in 1986 in Sendai, Japan, the CAV symposium has grown to become the world's foremost event dedicated to cavitation. Hosted by EPFL (Ecole Polytechnique Fédérale de Lausanne) and staged at the SwissTech Convention Center, CAV2015 is a unique opportunity to exchange with leading scientists and industry experts about the latest advances in theoretical modelling, numerical simulation and experimentation related to cavitation phenomena with a special emphasis on practical applications. The topics covered by CAV2015 include cavitation in ¬fluid machinery and fuel systems, bubble dynamics, cavitation erosion, advanced numerical simulation, sonochemistery, biomedicine and experimental techniques. CAV2015 will also host an exhibition of leading providers of state of the art measurement equipment, including high-speed imaging systems, non-intrusive velocimetry, pressure sensors, as well as numerical solvers. We have accepted over 190 papers, which will be presented in four parallel sessions. The proceedings will appear in the open access Journal of Physics: Conference Series (JPCS), which is part of the IOP Conference Series. All published papers are fully citable and upon publication will be free to download in perpetuity. We would like to thank all the reviewers for their great help during the selection process. We will also propose six plenary speakers to highlight cavitation issues in different fields. Finally, we would like to warmly thank our sponsors for their valuable support and the local Organizing Committee for the efforts in setting up this important event. We look forward to seeing you in Lausanne!

Analysis of the rotation period of asteroids (1865) Cerberus, (2100) Ra-Shalom, and (3103) Eger – search for the YORP effect

Czech Academy of Sciences Publication Activity Database

Ďurech, J.; Vokrouhlický, D.; Baransky, A.R.; Breiter, S.; Burkhonov, O.A.; Cooney, W.R.; Fuller, V.; Gaftonyuk, N. M.; Gross, J.; Inasaridze, R.Ya.; Kaasalainen, M.; Krugly, Yu. N.; Kvaratshelia, O.I.; Litvinenko, E.A.; Macomber, B.; Marchis, F.; Molotov, I.E.; Oey, J.; Polishook, D.; Pollock, J.; Pravec, Petr; Sárneczky, K.; Shevchenko, V. G.; Slyusarev, I.; Stephens, R.; Szabó, G.; Terrell, D.; Vachier, F.; Vanderplate, Z.; Viikinkoski, M.; Warner, B. D.

2012-01-01

Roč. 547, November (2012), A10/1-A10/9 ISSN 0004-6361 R&D Projects: GA ČR GAP209/12/0229 Institutional support: RVO:67985815 Keywords : minor planets * asteroids * data analysis Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 5.084, year: 2012

The Galactic unclassified B[e] star HD50138 III. The short-term line profile variability of its photospheric lines

Czech Academy of Sciences Publication Activity Database

Borges Fernandes, M.; Kraus, Michaela; Nickeler, Dieter Horst; de Cat, P.; Lampens, P.; Pereira, C. A. B.; Oksala, Mary E.

2012-01-01

Roč. 548, November (2012), A13/1-A13/9 ISSN 0004-6361 R&D Projects: GA ČR(CZ) GAP209/11/1198 Institutional support: RVO:67985815 Keywords : stars * oscillations * mass-loss Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 5.084, year: 2012

Observational constraints for the circumstellar disk of the B[e] star CPD-52 9243

Czech Academy of Sciences Publication Activity Database

Cidale, L.S.; Borges Fernandes, M.; Andruchow, I.; Arias, M.L.; Kraus, Michaela; Chesneau, O.; Kanaan, S.; Curé, M.; de Wit, W.J.; Muratore, M.F.

2012-01-01

Roč. 548, November (2012), A72/1-A72/9 ISSN 0004-6361 R&D Projects: GA ČR(CZ) GAP209/11/1198 Institutional support: RVO:67985815 Keywords : supergiants * stars * winds Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 5.084, year: 2012

diversité des pratiques d'intégration agriculture – élevage

African Journals Online (AJOL)

BOL BI

Dans le sud la région de Maradi, l'agriculture et l'élevage sont les deux principales activités socio-économiques qui occupent environ 95% de la population. Ces activités sont pratiquées de façon intégrée dans un contexte de très forte pression démographique (plus de 70 habitants/km²). Pour comprendre les pratiques ...

Identification and synchronization of the common cosmic-ray signal in the IntCal13 14C calibration and the Greenland ice-core 10Be records

Science.gov (United States)

Muscheler, Raimund; Adolphi, Florian; Bronk Ramsey, Christopher; Rasmussen, Sune; Hughen, Konrad; Cooper, Alan; Turney, Chris

2017-04-01

The production rates of cosmogenic radionuclides (such as 10Be and 14C) are modulated by the solar and geomagnetic shielding of galactic cosmic rays. In addition, 14C and 10Be are influenced by the carbon cycle and the atmospheric transport and deposition, respectively. Isolating and identifying the common production signal allows us to synchronize ice core 10Be and tree ring 14C records during the Holocene (Adolphi and Muscheler, 2016), thereby connecting ice core climate records with 14C-dated records. Extending this comparison further back in time is challenging due to deteriorating quality of the 14C calibration record, IntCal13, (Reimer et al., 2013) and possible unidentified climate influences on the ice-core 10Be records. Nevertheless, by focusing on the most prominent production-rate features this comparison can be extended far back into the last glacial where, for example, the linkage of tree-ring based Kauri 14C data and the Greenland ice-core time scale (GICC05) suggested unresolved data and/or time scale differences around the period of the Laschamp geomagnetic field minimum at about 42000 yrs BP (Muscheler et al., 2014). Here we show that the data underlying the IntCal13 14C record and the ice-core 10Be records exhibit common variability that allows us to tentatively link the ice core GICC05 time scale to the radiocarbon time scale for almost the complete radiocarbon dating range. The observed time scale differences could be related to uncertainties in both the U/Th-based dating of the IntCal13 calibration data set and the GICC05 time scale, and we show that the two can be reconciled within the uncertainties of the ice-core layer counting. This direct comparison between IntCal13 and 10Be also suggests that the 14C differences shown in (Muscheler et al., 2014) around the Laschamp geomagnetic field minimum can be reduced by moderate adjustments to the GICC05 time scale. References: Adolphi, F., and Muscheler, R., 2016, Synchronizing the Greenland ice

9th Pacific Basin Nuclear Conference. Nuclear energy, science and technology - Pacific partnership. Proceedings Volume 1

International Nuclear Information System (INIS)

1994-04-01

The theme of the 9th Pacific Basin Nuclear conference held in Sydney from 1-6 May 1994, embraced the use of the atom in energy production and in science and technology. The focus was on selected topics of current and ongoing interest to countries around the Pacific Basin. The two-volume proceedings include both invited and contributed papers. They have been indexed separately. This document, Volume 1 covers the following topics: Pacific partnership; perspectives on nuclear energy, science and technology in Pacific Basin countries; nuclear energy and sustainable development; economics of the power reactors; new power reactor projects; power reactor technology; advanced reactors; radioisotope and radiation technology; biomedical applications

Breaking Through the n^3 Barrier: Faster Object Type Inference

DEFF Research Database (Denmark)

Henglein, Fritz

1999-01-01

Invited paper selected from 4th Int'l Workshop on Foundations of Object-Oriented Languages (FOOL), January 1997, Paris, France......Invited paper selected from 4th Int'l Workshop on Foundations of Object-Oriented Languages (FOOL), January 1997, Paris, France...

Determination of U and Th α-emitters in NORM samples through extraction chromatography by using new and recycled UTEVA resins

International Nuclear Information System (INIS)

Casacuberta, N.; Lehritani, M.; Mantero, J.; Masqué, P.; Garcia-Orellana, J.; Garcia-Tenorio, R.

2012-01-01

This manuscript describes a protocol for the determination of U and Th isotopes via alpha spectrometry in NORM samples containing high concentrations of these radionuclides, up to kBq kg −1 . This technique is based on extraction chromatography with UTEVA (Triskem Int.) resins and it has been tested using both NORM samples from a phosphate industry and reference materials. The results proved that this method is highly optimized in terms of accuracy and precision when dealing with NORM samples. Recycling of UTEVA columns was also checked using NORM samples and successful results were obtained for both U and Th isotopes, thus proving the feasibility of re-using these type of columns. - Highlights: ► U and Th isotopes in NORM samples are determined via alpha spectrometry. ► The results show a highly optimized data in terms of accuracy and precision. ► Recycling of UTEVA columns was also checked and successful results were obtained.

Vertical Jump and Leg Power Normative Data for Colombian Schoolchildren Aged 9-17.9 Years: The FUPRECOL Study.

Science.gov (United States)

Ramírez-Vélez, Robinson; Correa-Bautista, Jorge E; Lobelo, Felipe; Cadore, Eduardo L; Alonso-Martinez, Alicia M; Izquierdo, Mikel

2017-04-01

Ramírez-Vélez, R, Correa-Bautista, JE, Lobelo, F, Cadore, EL, Alonso-Martinez, AM, and Izquierdo, M. Vertical jump and leg power normative data for Colombian schoolchildren aged 9-17.9 years: the FUPRECOL study. J Strength Cond Res 31(4): 990-998, 2017-The aims of the present study were to generate normative vertical jump height and predicted peak power (Ppeak) data for 9- to 17.9-year-olds and to investigate between-sex and age group differences in these measures. This was a cross-sectional study of 7,614 healthy schoolchildren (boys n = 3,258 and girls n = 4,356, mean [SD] age 12.8 [2.3] years). Each participant performed 2 countermovement jumps; jump height was calculated using a Takei 5414 Jump-DF Digital Vertical (Takei Scientific Instruments Co., Ltd.). The highest jump was used for analysis and in the calculation of predicted Ppeak. Centile smoothed curves, percentiles, and tables for the 3rd, 10th, 25th, 50th, 75th, 90th, and 97th percentiles were calculated using Cole's LMS (L [curve Box-Cox], M [curve median], and S [curve coefficient of variation]) method. The 2-way analysis of variance tests showed that maximum jump height (in centimeters) and predicted Ppeak (in watts) were higher in boys than in girls (p jump height and Ppeak in all ages. In boys, the maximum jump height and predicted Ppeak 50th percentile ranged from 24.0 to 38.0 cm and from 845.5 to 3061.6 W, respectively. In girls, the 50th percentile for jump height ranged from 22.3 to 27.0 cm, and the predicted Ppeak was 710.1-2036.4 W. For girls, jump height increased yearly from 9 to 17.9 years old. Our results provide, for the first time, sex- and age-specific vertical jump height and predicted Ppeak reference standards for Colombian schoolchildren aged 9-17.9 years.

El intérprete de Lengua de Signos en el ámbito educativo: problemática y propuestas de mejora

Directory of Open Access Journals (Sweden)

Marina Uría Fernández

2017-01-01

Full Text Available La figura del intérprete de Lengua de Signos es un recurso en el aprendizaje de los alumnos con discapacidad auditiva que contribuye al desarrollo de la experiencia bilingüe en los centros educativos españoles. Este estudio se centra en la figura del intérprete de Lengua de Signos como pieza fundamental en el entorno de aprendizaje del alumnado sordo en la Comunidad Autónoma de Castilla y León. El objetivo general del estudio es analizar los factores que obstaculizan y facilitan la labor del intérprete en los centros educativos de Castilla y León. Se ha utilizado una metodología de corte cualitativo de exploración descriptiva y evaluativa orientada a la decisión, utilizando el análisis DAFO para la interpretación de los resultados obtenidos. La muestra de este estudio ha estado constituida por diez intérpretes de Lengua de Signos que ejercían su profesión en centros públicos de Castilla y León durante el curso académico 2013/2014, seleccionados a través de la técnica cualitativa de informantes clave. Los resultados obtenidos destacan el desconocimiento del profesional intérprete de Lengua de Signos por parte de la comunidad educativa, la falta de criterios normativos que regulen equitativamente la participación de este profesional en el centro, y finalmente, la necesidad de una mayor integración de esta figura en el ámbito educativo para mejorar la calidad de la experiencia bilingüe de los alumnos sordos. Algunas de las propuestas más relevantes para superar los puntos débiles y potenciar los puntos fuertes identificados en el estudio son potenciar el trabajo en equipo entre todos los agentes educativos y sociales, la sensibilización y asesoramiento de toda la comunidad educativa y el desarrollo de estrategias individualizadas y adaptadas a las necesidades de cada uno de estos alumnos.

The Issues of the Diocesan Organization of the Breton Сhurch in the 9th Century

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Arteev Mikhail

2016-07-01

Full Text Available Using a considerable variety of sources (chronicles, hagiography, charters, letters the author of the present article shows a process of formation of the system of the Breton bishoprics during the Carolingian era, when this land was a part of the Frankish empire. There were no regular episcopal sees in Brittany before the 9th century: Dol and Léon were monastery-bishoprics; Tréguier and Aleth, possibly, had the same nature. Bishops appeared there only from time to time. In the middle of the 9th century there were sees in Aleth, Quimper, Léon, and Dol. And they were substituted regularly. Obviously, an attempt to establish episcopal sees in Tréguier and Saint-Brieuc was vain. Along with a territorial expansion of the power of the Breton duke three others bishoprics founded in the Roman and post-Roman times — Nantes, Rennes, and Vannes — became parts of the Breton church. The sought of duke Nominoe for the independence from West-Frankish kingdom led to the «schism» of 849 which actually meant a separation of the most of the Breton bishoprics from the Gallic Church. King Salomon in 860s tried to promote the see of Dol to a metropolitan grade, but with no success due to determined resistance of the pope Nicolas I and the Frankish bishops. But in spite of the absence of archbishopric in Brittany the church of the region from the last third of the ninth century onwards run its quite different from the rest of the Western Сhurch way of life with its own synods and traditions. In this sense the Breton Church resembled other Celtic Churches of the Early Middle Ages.

FY 1998 Report on development of technologies for commercialization of photovoltaic power systems. International co-operative project (IEA implementing agreement for a co-operative programme on photovoltaic power systems, 9th and 10th executive committee meetings); 1998 nendo taiyoko hatsuden system jitsuyoka gijutsu kaihatsu kokusai kyoryoku jigyo. IEA taiyoko hatsuden system kenkyu kyoryoku program jisshi kyotei dai 10 kai dai 9 kai iinkai

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-03-01

Described herein are outline of the International Energy Agency/Co-operative programme on Photovoltaic Power Systems (IEA/PVPS), and minutes of the 9th and 10th executive committee meetings. Japan signed the IEA Implementing Agreement for a co-operative programme on Photovoltaic Power Systems in April 1993, and has been participating in the programme for research and development, demonstration, analysis, information exchange and introduction promotion, among others. The tasks are composed of exchange and dissemination of information on PVPS, operational performance and design of PVPS, use of PVPS in stand alone and island applications, grid interconnection of building integrated and other dispersed PVPS, design and grid interconnection of dispersed PVPS, e.g., roof type, design and operation of modular PV plants for large scale power generation, PV in the built environment, and feasibility study on large scale PV power generation utilizing desert areas. The 9th and 10th executive committee meetings include the co-operative programme progress reports and technical tours. (NEDO)

INT (2-(4-Iodophenyl)-3-(4-Nitrophenyl)-5-(Phenyl) Tetrazolium Chloride) Is Toxic to Prokaryote Cells Precluding Its Use with Whole Cells as a Proxy for In Vivo Respiration.

Science.gov (United States)

Villegas-Mendoza, Josué; Cajal-Medrano, Ramón; Maske, Helmut

2015-11-01

Prokaryote respiration is expected to be responsible for more than half of the community respiration in the ocean, but the lack of a practical method to measure the rate of prokaryote respiration in the open ocean resulted in very few published data leaving the role of organotrophic prokaryotes open to debate. Oxygen consumption rates of oceanic prokaryotes measured with current methods may be biased due to pre-incubation size filtration and long incubation times both of which can change the physiological and taxonomic profile of the sample during the incubation period. In vivo INT reduction has been used in terrestrial samples to estimate respiration rates, and recently, the method was introduced and applied in aquatic ecology. We measured oxygen consumption rates and in vivo INT reduction to formazan in cultures of marine bacterioplankton communities, Vibrio harveyi and the eukaryote Isochrysis galbana. For prokaryotes, we observed a decrease in oxygen consumption rates with increasing INT concentrations between 0.05 and 1 mM. Time series after 0.5 mM INT addition to prokaryote samples showed a burst of in vivo INT reduction to formazan and a rapid decline of oxygen consumption rates to zero within less than an hour. Our data for non-axenic eukaryote cultures suggest poisoning of the eukaryote. Prokaryotes are clearly poisoned by INT on time scales of less than 1 h, invalidating the interpretation of in vivo INT reduction to formazan as a proxy for oxygen consumption rates.

Proceedings of the 18th technical meeting on nuclear reactor and radiation for KURRI engineers and the 9th technical official group section 5 meeting in Kyoto University

International Nuclear Information System (INIS)

2010-03-01

This report is a summary of 18th Technical Meeting on Nuclear Reactor and Radiation for KURRI Engineers in Kyoto University. This was also the 9th meeting for technical official group section 5 (nuclear and radiation) in Kyoto University. In the workshop, three special lectures held were: (1) 'On Border Between Subcritical and Supercritical', (2) 'Memories of Nuclear Power Plant Management for 40 Years', and (3) 'Introduction of Technical Office in Faculty of Engineering, Kyoto University'. The technical presentations held were: (1) 'Radiation Background Study of Specialty Products in Senshu Region', (2) 'Introduction of Radioactivation Analysis at KUR', (3) 'Consideration of Critical Approach Method for KUR Low-Enrichment Fuel Reactor Core Using SRAC', (4) 'Evaluation of Temperature Coefficient of KUR Low-Enrichment Fuel Reactor Core Using SRAC'. As training for technical staffs in Technical Office, we visited the facility in Ashiu Research Forest. An introduction of this facility and the comments from the participants were included in this report. (S.K.)

Structural phase stability of ThSb and ThAs under pressure

International Nuclear Information System (INIS)

Venkatasubramaniam, K.; Rajagopalan, M.; Palanivel, B.; Kalpana, G.

1997-01-01

The high-pressure behaviour of thorium monopnictides is of considerable interest as these systems exhibit structural phase transitions under pressure. At ambient conditions these compounds crystallize in the NaCl-type(B1) structure. Experiments show that with the application of pressure these compounds transform to the CsCl-type (B2) structure. ThSb and ThAs are found to exhibit B1-B2 transition in the pressure range between 9-12 GPa and 1826 GPa respectively. In this work, we present the electronic and high-pressure behaviour of ThAs and ThSb performed using the tight-binding linear muffin-tin orbital method. The total energies within the atomic sphere approximation were calculated as a function of volume for both the B1 and B2 structures. The total energy calculations reveal that both ThSb and ThAs are stable in the B1 structure at ambient conditions and undergo structural transition to the B2 structure at pressures 78 and 240 kbar respectively, which are in good agreement with the experimental values. The calculated values of equilibrium lattice parameter and the transition pressure are found to be in good agreement with the experimental results. (author)

9th Annual Systems Engineering Conference: Volume 4 Thursday

Science.gov (United States)

2006-10-26

ISO /IEC 27000 series – Information Security Management System (ISMS) – ISO /IEC 17799:2005 – Code of Practice for Information Security Management...October 2006, Track 2 Standards Organizations Supporting Assurance ISO IEC JTC1TC176 SC1 SC22 Terminology Software Engineering Language, OS SC7...Information Assurance IEEE CS ISO IEC IEEE CS NIST FISMA Projects U.S. Gov’t DoD MIL-STDsPolicy Memos OMG Knowledge Discovery Models OMG 259th Annual

9th International Bielefeld Conference 2009: Upgrading the eLibrary: Enhanced Information Services Driven by Technology and Economics

Directory of Open Access Journals (Sweden)

Almuth Gastinger

2009-10-01

Full Text Available Thisarticle reports on the 9th International Bielefeld Conference ‘Upgrading the eLibrary: Enhanced Information Services Driven by Technology and Economics’, 3-5 February 2009, in Bielefeld, Germany. The conference focused on future challenges for libraries regarding the development of information services and infrastructures that meet the changing needs of scholarly communication, collaboration (e-science and publication (open access as well as new requirements regarding teaching and learning (virtual learning spaces. In addition attention was paid to economic conditions and strategic positioning of libraries as a general framework for information services.

Création d'outils pour la mesure de l'intégration des technologies de ...

International Development Research Centre (IDRC) Digital Library (Canada)

... dont les technologies de l'information et de la communication (TIC) sont intégrées en classe. ... Colombia, Mexico, Peru, Uruguay. Project Leader. Susana Martínez Restrepo. Institution. Fundación para la Educación Superior y el Desarrollo.

Facteurs associés à l’intégration stratégique des TIC par le personnel enseignant

OpenAIRE

Busana, Gilbert

2001-01-01

Ce mémoire porte sur les facteurs qui incitent le personnel enseignant à faire une intégration stratégique des TIC1. Nous avons remarqué qu’une partie des enseignants et des enseignantes, en faible proportion, réussissent à faire une telle intégration, et qu’une partie n’en font pas. L’objectif de cette recherche est d’identifier les facteurs qui tendent à avoir une influence sur ce phénomène, ainsi que de saisir leur rôle et de comprendre comment ils opèrent. Dans une premiè...

Pour que l'exploitation minière marche : intégrer des petits mineurs ...

International Development Research Centre (IDRC) Digital Library (Canada)

31 janv. 2011 ... Pour que l'exploitation minière marche : intégrer des petits mineurs pauvres dans ... ou reconnaissance de l'État est le mode de vie d'environ 13 millions de ... Selon l'Organisation internationale du travail (OIT), entre 11 et 13 millions ... mineurs subissent des discriminations et n'ont accès qu'aux parties les ...

Intégration régionale, commerce et essor du secteur privé (Namibie ...

International Development Research Centre (IDRC) Digital Library (Canada)

Intégration régionale, commerce et essor du secteur privé (Namibie). La Namibie aspire à atteindre un niveau de vie comparable à celui des pays développés d'ici 2030. Le Namibian Economic Policy Research Unit (NEPRU), le principal institut de recherche sur la politique économique du pays, a pour mandat d'aider le ...

Att sluta eller inte sluta : En litteraturstudie om tobaksavvänjningsmetoder

OpenAIRE

Bjellman, Karin

2007-01-01

Att sluta eller inte sluta? En litteraturstudie om tobaksavvänjningsmetoder Bjellman, K. Tobaksbruket har en lång historia, och de tobaksrelaterade sjukdomarna kostar samhället miljarder i sjukvårdskostnader och produktionsbortfall varje år. Andelen rökare minskar stadigt i Sverige, idag röker ca 15 procent av befolkningen. Resultaten från olika metoder för tobaksavvänjning är tämligen blygsamma, och ugefär nittio procent av de som slutar röka gör det på egen hand. Syftet med denna studie var...

PREFACE: 9th World Congress on Computational Mechanics and 4th Asian Pacific Congress on Computational Mechanics

Science.gov (United States)

Khalili, N.; Valliappan, S.; Li, Q.; Russell, A.

2010-07-01

The use for mathematical models of natural phenomena has underpinned science and engineering for centuries, but until the advent of modern computers and computational methods, the full utility of most of these models remained outside the reach of the engineering communities. Since World War II, advances in computational methods have transformed the way engineering and science is undertaken throughout the world. Today, theories of mechanics of solids and fluids, electromagnetism, heat transfer, plasma physics, and other scientific disciplines are implemented through computational methods in engineering analysis, design, manufacturing, and in studying broad classes of physical phenomena. The discipline concerned with the application of computational methods is now a key area of research, education, and application throughout the world. In the early 1980's, the International Association for Computational Mechanics (IACM) was founded to promote activities related to computational mechanics and has made impressive progress. The most important scientific event of IACM is the World Congress on Computational Mechanics. The first was held in Austin (USA) in 1986 and then in Stuttgart (Germany) in 1990, Chiba (Japan) in 1994, Buenos Aires (Argentina) in 1998, Vienna (Austria) in 2002, Beijing (China) in 2004, Los Angeles (USA) in 2006 and Venice, Italy; in 2008. The 9th World Congress on Computational Mechanics is held in conjunction with the 4th Asian Pacific Congress on Computational Mechanics under the auspices of Australian Association for Computational Mechanics (AACM), Asian Pacific Association for Computational Mechanics (APACM) and International Association for Computational Mechanics (IACM). The 1st Asian Pacific Congress was in Sydney (Australia) in 2001, then in Beijing (China) in 2004 and Kyoto (Japan) in 2007. The WCCM/APCOM 2010 publications consist of a printed book of abstracts given to delegates, along with 247 full length peer reviewed papers published with

Géohistoire de la Nouvelle-Zélande: unité territoriale et intégration à l’espace-monde

Directory of Open Access Journals (Sweden)

François Cognard

2012-03-01

Full Text Available Tout au long de son histoire, la société néo-zélandaise s'est efforcée de nouer des liens avec le monde extérieur tout en maintenant l'intégrité de son territoire multi-insulaire. Selon une perspective privilégiant le temps long, cet article décrit les spécificités physiques et humaines de l'archipel du Pacifique sud ainsi que son processus d'intégration à l'économie monde. Une approche qui, à l'aide de la modélisation graphique, souligne l'originalité des dynamiques spatiales du territoire national caractérisées par l'opposition entre ses deux principales îles.

Neutron Diffraction Study On Gamma To Alpha Phase Transition In Ce0.9th0.1 Alloy

Energy Technology Data Exchange (ETDEWEB)

Lashley, Jason C1 [Los Alamos National Laboratory; Heffner, Robert H [Los Alamos National Laboratory; Llobet, A [Los Alamos National Laboratory; Darling, T W [U OF NEVADA; Jeong, I K [PUSAN NATL UNIV

2008-01-01

Comprehensive neutron diffraction measurements were performed to study the isostructural {gamma} {leftrightarrow} {alpha} phase transition in Ce{sub 0.9}Th{sub 0.1} alloy. Using Rietveld refinements, we obtained lattice and thermal parameters as a function of temperature. From the temperature slope of the thermal parameters, we determined Debye temperatures {Theta}{sup {gamma}}{sub D} = 133(1) K and {Theta}{sup {alpha}}{sub D} = 140(1) K for the {gamma} phase and the {alpha} phase, respectively. This result implies that the vibrational entropy change is not significant at the {gamma} {leftrightarrow} {alpha} transition, contrary to that from elemental Cerium [Phys. Rev. Lett. 92, 105702, 2004].

30. MPA-Seminar 'Safety and reliability in energy technology' in conjunction with the 9th German-Japanese seminar. Vol. 1 (Papers 1-26); 30. MPA-Seminar 'Sicherheit und Verfuegbarkeit in der Energietechnik' in Verbindung mit dem 9. Deutsch-Japanischen Seminar. Bd. 1 (Vortraege 1-26)

Energy Technology Data Exchange (ETDEWEB)

Roos, E. (comp.)

2004-07-01

The 30th MPA-seminar on ''Safety and Availability in Energy Engineering'' was held in conjuction with the 9th German-Japanese Seminar. The 52 contributions were published in two volumes. Volume 1 contains the contributions to the following sessions: fracture mechanics, fatigue, welding, environmental impact and European research projects. Volume 2 contains contributions of sessions 6-9: high-temperature application, modelling-simulation, ageing management and non-destructive testing. (uke)

30. MPA-Seminar 'Safety and reliability in energy technology' in conjunction with the 9th German-Japanese seminar. Vol. 2 (Papers 27-53); 30. MPA-Seminar 'Sicherheit und Verfuegbarkeit in der Energietechnik' in Verbindung mit dem 9. Deutsch-Japanischen Seminar. Bd. 2 (Vortraege 27-53)

Energy Technology Data Exchange (ETDEWEB)

Roos, E. (comp.)

2004-07-01

he 30th MPA-seminar on ''Safety and Availability in Energy Engineering'' was held in conjuction with the 9th German-Japanese Seminar. The 52 contributions were published in two volumes. Volume 1 contains the contributions to the following sessions: fracture mechanics, fatigue, welding, environmental impact and European research projects. Volume 2 contains contributions of sessions 6-9: high-temperature application, modelling-simulation, ageing management and non-destructive testing. (uke)

9th Workshop on Stochastic Analysis and Related Topics

CERN Document Server

Decreusefond, Laurent; Stochastic Analysis and Related Topics

2012-01-01

Since the early eighties, Ali Suleyman Ustunel has been one of the main contributors to the field of Malliavin calculus. In a workshop held in Paris, June 2010 several prominent researchers gave exciting talks in honor of his 60th birthday. The present volume includes scientific contributions from this workshop. Probability theory is first and foremost aimed at solving real-life problems containing randomness. Markov processes are one of the key tools for modeling that plays a vital part concerning such problems. Contributions on inventory control, mutation-selection in genetics and public-pri

Insularité et démographie dans la mer Intérieure japonaise

Directory of Open Access Journals (Sweden)

Philippe PELLETIER

1992-12-01

Full Text Available Les îles éloignées (ritô tiennent une place importante dans l’espace japonais. Les îles de la mer Intérieure se dépeuplèrent fortement pendant la Haute Croissance. Un graphique corrélant leur évolution démographique et leur distance par rapport à Honshû et Shikoku nous aide à comprendre que l’éloignement insulaire joua un rôle relatif.

Extended networks, porous sheets, and chiral frameworks. Thorium materials containing mixed geometry anions: Structures and properties of Th(SeO3)(SeO4), Th(IO3)2(SeO4)(H2O)3.H2O, and Th(CrO4)(IO3)2

International Nuclear Information System (INIS)

Sullens, Tyler A.; Almond, Philip M.; Byrd, Jessica A.; Beitz, James V.; Bray, Travis H.; Albrecht-Schmitt, Thomas E.

2006-01-01

Three novel Th(IV) compounds containing heavy oxoanions, Th(SeO 3 )(SeO 4 ) (1), Th(IO 3 ) 2 (SeO 4 )(H 2 O) 3 .H 2 O (2), and Th(CrO 4 )(IO 3 ) 2 (3), have been synthesized under mild hydrothermal conditions. Each of these three distinct structures contain trigonal pyramidal and tetrahedral oxoanions. Compound 1 adopts a three-dimensional structure formed from ThO 9 tricapped trigonal prisms, trigonal pyramidal selenite, SeO 3 2- , anions containing Se(IV), and tetrahedral selenate, SeO 4 2- , anions containing Se(VI). The structure of 2 contains two-dimensional porous sheets and occluded water molecules. The Th centers are found as isolated ThO 9 tricapped trigonal prisms and are bound by four trigonal pyramidal iodate anions, two tetrahedral selenate anions, and three coordinating water molecules. In the structure of 3, the Th(IV) cations are found as ThO 9 tricapped trigonal prisms. Each Th center is bound by six IO 3 1- anions and three CrO 4 2- anions forming a chiral three-dimensional structure. Second-harmonic generation of 532nm light from 1064nm radiation by a polycrystalline sample of 3 was observed. Crystallographic data (193K, MoKα, λ=0.71073): 1; monoclinic, P2 1 /c; a=7.0351(5)A, b=9.5259(7)A, c=9.0266(7)A, β=103.128(1), Z=4, R(F)=2.47% for 91 parameters with 1462 reflections with I>2σ(I); 2, monoclinic, P2 1 /n, a=7.4889(9)A, b=8.002(1)A, c=20.165(3)A, β=100.142(2), Z=4, R(F)=4.71% for 158 parameters with 2934 reflections with I>2σ(I); 3, orthorhombic, P2 1 2 1 2 1 , a=7.3672(5)A, b=9.3617(6)A, c=11.9201(7)A, Z=4, R(F)=2.04% for 129 parameters with 2035 reflections with I>2σ(I)

Effect of interfacial layers on dielectric properties in very thin SrBi2Ta2O9 capacitors

International Nuclear Information System (INIS)

Moon, Bum-Ki; Isobe, Chiharu; Hironaka, Katsuyuki; Hishikawa, Shinichi

2001-01-01

The effect of interfacial layers on the dielectric properties in very thin SrBi 2 Ta 2 O 9 (SBT) capacitors has been investigated using static measurements. Total permittivity (ε t ) decreased as the film thickness was reduced in both Pt/SBT/Pt and Ir/SBT/Pt capacitors. The contribution of the interfacial capacitance (C int ) and bulk capacitance to the total capacitance indicates that C int of the Ir/SBT/Pt structure was lower than that of the Pt/SBT/Pt structure, while the bulk permittivity (ε b ) was essentially the same. The dispersion of all capacitors followed the power law, while the Ir/SBT/Pt capacitor showed a larger dispersion of C int . These results suggest that the Pt/SBT/Pt capacitor is preferred for obtaining the high performance with less effect of the interfacial layers on the dielectric properties. [copyright] 2001 American Institute of Physics

Hypnose, sommeil, placebo ? : Les réponses de la Théorie neuronale de la Cognition – Tome 2

OpenAIRE

Touzet , Claude

2014-01-01

International audience; Initialement uniquement dédié aux quelques « faits » comme :l'hypnose, le plaisir, le sommeil et les rêves, la responsabilité, l'effet placebo et la schizophréniequi n'avaient pas reçu d'explications de la part de la Théorie neuronale de la Cognition (tome 1 – Conscience, intelligence, libre-arbitre), ce second opus a rapidement dévié de sa mission originale pour intégrer des aspects encore plus controversés, comme :- le paranormal,- l'influence de l'intention sur la r...

IAEA consultants' meeting: 9th meeting of atomic and molecular data centres and ALADDIN network, Vienna, September 20 and 21, 1990

International Nuclear Information System (INIS)

Janev, R.K.

1990-11-01

This Summary Report contains the proceedings and the conclusions of the IAEA Consultants' Meeting: 9th Meeting of Atomic and Molecular Data Centres and ALADDIN Network, convened on September 20 and 21, 1990, at the IAEA Headquarters in Vienna. The Progress Reports of national atomic data centres and reports on the ALADDIN status and developments are also included as appendices to the present Report. (author). Refs, figs and tabs

Mise au point de la protection intégrée du colza : exemple du phoma (Leptosphaeria maculans

Directory of Open Access Journals (Sweden)

Aubertot Jean-Noël

2003-05-01

Full Text Available En France, le phoma est considéré comme la maladie la plus préoccupante du colza. Il n’existe aucune méthode de lutte à la fois efficace, rentable et respectueuse de l’environnement. Il apparaît donc nécessaire de développer la lutte intégrée de la culture contre cette maladie. Cette communication présente les résultats d’un programme de recherche visant à analyser et à modéliser les effets des systèmes de culture sur le développement de la maladie. Des pistes concrètes pour la mise en oeuvre de la lutte intégrée contre le phoma sont proposées.

Proceedings of the 9th symposium on JAERI's Reimei Research Program

International Nuclear Information System (INIS)

Yamashita, Toshiyuki

2005-09-01

The Reimei (Dawn) Research Program is a research project based on public application to be conducted within the framework of the Reimei Research Promotion project of the Japan Atomic Energy Research Institute. The objective of the program is to encourage original and/or unique ideas in the field of fundamental nuclear science and nuclear energy. The Symposium on JAERI's Reimei Research Program carried out in the 2004 fiscal year was held at Tokai Research Establishment on 28th and 29th of June 2005. 38 papers were reported through the short presentation followed by the poster presentation, and animated discussions were carried out by about 120 attendees. These presented papers were compiled in the proceedings. We hope that new researches will be grown and developed by the help of Reimei Research Promotion project. The 37 of the presented papers are indexed individually. (J.P.N.)

Gluten-free diet does not influence the occurrence and the Th1/Th17-Th2 nature of immune-mediated diseases in patients with coeliac disease.

Science.gov (United States)

Imperatore, Nicola; Rispo, Antonio; Capone, Pietro; Donetto, Sara; De Palma, Giovanni Domenico; Gerbino, Nicolò; Rea, Matilde; Caporaso, Nicola; Tortora, Raffaella

2016-07-01

Coeliac disease (CD) is the most common Th1-mediated enteropathy, frequently associated with other immune-mediated disorders (IMD). To evaluate: (1) the prevalence of IMD at the time of and after CD diagnosis; (2) a possible change in immune response to gluten free diet (GFD); (3) the potential role of GFD in reducing and/or preventing IMD in CD. Prospective study including all consecutive adult CD patients who underwent investigations for Th1-Th17/Th2-IMD at the time of CD diagnosis and after a 5-year follow-up period. 1255 CD were enrolled. Of these, 257 patients (20.5%) showed IMD at the time of CD diagnosis, with 58.4% presenting a Th1/Th17-IMD. After a 5-year follow-up period, 682 patients (54.3%) showed new IMD despite GFD. Of these, 57.3% presented a Th1/Th17-IMD and 42.7% a Th2-IMD (p=0.8). When compared the prevalence of each type of IMD before and after CD diagnosis, we did not identify any significant "switch" from Th1/Th17- to Th2-IMD or vice versa. The number of patients with Th1/Th17- and/or Th2-IMD increased during the GFD period (20.5% vs 54.3%; p<0.01; OR 1.9). The prevalence of IMD at the time of CD diagnosis is high and it seems to increase in the follow-up period despite GFD. Copyright © 2016 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

Lutte contre le changement climatique et maîtrise de la demande d’énergie : introduction au dossier thématique

OpenAIRE

Aubrée, Loïc; Calvo-Mendieta, Iratxe

2017-01-01

Cet article constitue l’introduction du dossier thématique consacré à la lutte contre le changement climatique et la maîtrise de la demande d’énergie. Après un dossier de la Revue Développement Durable et Territoires, paru en décembre 2015 et en juillet 2016, abordant la question du climat sous l’angle de l’adaptation, les articles de ce dossier s’intéressent aux politiques, aux programmes et aux instruments qui contribuent à l’atténuation du changement climatique. L’objectif est la diminutio...

Circulating endothelial progenitor cells, Th1/Th2/Th17-related cytokines, and endothelial dysfunction in resistant hypertension.

Science.gov (United States)

Magen, Eli; Feldman, Arie; Cohen, Ziona; Alon, Dora Ben; Minz, Evegeny; Chernyavsky, Alexey; Linov, Lina; Mishal, Joseph; Schlezinger, Menacham; Sthoeger, Zev

2010-02-01

A possible link between chronic vascular inflammation and arterial hypertension is now an object of intensive studies. To compare Th1/Th2/Th17 cells-related cytokines, circulating endothelial progenitor cells (EPC), and endothelial function in subjects with resistant arterial hypertension (RAH) and controlled arterial hypertension (CAH). Blood pressure was measured by electronic sphygmomanometer. EPC were identified as CD34+/CD133+/kinase insert domain receptor (KDR)+ cells by flow cytometry. Th1/Th2/Th17 cells-related cytokines were identified using the Human Th1/Th2/Th17 Cytokines MultiAnalyte ELISArray Kit. Endothelium-dependent (FMD) vasodilatation of brachial artery was measured by Doppler ultrasound scanning. RAH group (n = 20) and CAH group (n = 20) and 17 healthy individuals (control group) were recruited. In the RAH group, lower blood levels of EPC number (42.4 +/- 16.7 cells/mL) and EPC% (0.19 +/- 0.08%) were observed than in the CAH group (93.1 +/- 88.7 cells/mL; P = 0.017; 0.27 +/- 0.17; P = 0.036) and control group (68.5 +/- 63.6 cells/mL; P < 0.001; 0.28 +/- 0.17%; P = 0.003), respectively. Plasma transforming growth factor-beta1 levels were significantly higher in the RAH group (1767 +/- 364 pg/mL) than in the CAH group (1292 +/- 349; P < 0.001) and in control group (1203 +/- 419 pg/mL; P < 0.001). In the RAH group, statistically significant negative correlation was observed between systolic blood pressure and EPC% (r = -0.72, P < 0.01). FMD in the RAH group was significantly lower (5.5 +/- 0.8%) than in the CAH group (9.2 +/- 1.4; P < 0.001) and in healthy controls (10.1 +/- 1.1%; P < 0.001). RAH is characterized by reduced circulating EPC, substantial endothelial dysfunction, and increased plasma transforming growth factor-beta1 levels.

Interações entre o aluno com surdez, o professor e o intérprete em aulas de física: uma perspectiva Vygotskiana

Directory of Open Access Journals (Sweden)

Jaqueline Santos Vargas

2014-09-01

Full Text Available O estudo apresenta uma análise das interações entre o aluno com surdez, o professor e o intérprete em sala de aula, além do papel desses sujeitos no processo de inclusão do aluno surdo. Trata-se de uma pesquisa qualitativa realizada em 10 escolas públicas de Ensino Médio de Campo Grande-MS que receberam 24 alunos com surdez. Nessa análise utilizamos a abordagem histórico cultural de Vygotsky. Os resultados evidenciaram que apenas o intérprete interage efetivamente com esses alunos e pouco colabora para que eles interajam com pessoas que não dominam a Língua Brasileira de Sinais. Em sala de aula, o professor transfere ao intérprete a responsabilidade pelo ensino e a aprendizagem desses alunos.

Fish from Head to Tail: The 9th European Zebrafish Meeting in Oslo.

Science.gov (United States)

Griffiths, Gareth; Müller, Ferenc; Ledin, Johan; Patton, E Elizabeth; Gjøen, Tor; Lobert, Viola Hélène; Winther-Larsen, Hanne Cecilie; Mullins, Mary; Joly, Jean-Stephane; Weltzien, Finn-Arne; Press, Charles McLean; Aleström, Peter

2016-04-01

The 9th European Zebrafish Meeting took place recently in Oslo (June 28-July 2, 2015). A total of 650 participants came to hear the latest research news focused on the zebrafish, Danio rerio, and to its distant evolutionary relative medaka, Oryzias latipes. The packed program included keynote and plenary talks, short oral presentations and poster sessions, workshops, and strategic discussions. The meeting was a great success and revealed dramatically how important the zebrafish in particular has become as a model system for topics, such as developmental biology, functional genomics, biomedicine, toxicology, and drug development. A new emphasis was given to its potential as a model for aquaculture, a topic of great economic interest to the host country Norway and for the future global food supply in general. Zebrafish husbandry as well as its use in teaching were also covered in separate workshops. As has become a tradition in these meetings, there was a well-attended Wellcome Trust Sanger Institute and ZFIN workshop focused on Zebrafish Genome Resources on the first day. The full EZM 2015 program with abstracts can be read and downloaded from the EZM 2015 Web site zebrafish2015.org .

Properties of Fr-like Th^3+ from microwave spectroscopy of high-L Rydberg states of Th^2+

Science.gov (United States)

Keele, Julie; Smith, Chris; Woods, Shannon; Lundeen, Stephen; Fehrenbach, Charles

2012-06-01

Spectroscopy of high-L n= 28 Rydberg levels of Th^2+ was recently reported using the optical RESIS method [1]. Because the ground state of Fr-like Th^3+ is a ^2F5/2 level, each (n,L) Rydberg level of Th^2+ is split into six eigenstates whose relative positions are determined by long-range e-Th^3+ interactions. Measurements of those positions can be used to determine the Th^3+ properties that control those interactions, such as polarizabilities and permanent moments. We report a much improved study of n=28 levels with 9 Hanni, Shannon L. Woods, S.R. Lundeen, and C.W. Fehrenbach, Phys. Rev. A 83, 062501 (2011)[0pt] [2] U.I. Safronova, W.R. Johnson, and M.S. Safronova, Phys. Rev. A 74, 042511 (2006)

Functional and Logic Programming - 14th International Symposium (FLOPS 2018)

DEFF Research Database (Denmark)

This volume contains the proceedings of the 14th International Symposium on Functional and Logic Programming - FLOPS 2018 - held in Nagoya, Japan, May 9 - 11, 2018......This volume contains the proceedings of the 14th International Symposium on Functional and Logic Programming - FLOPS 2018 - held in Nagoya, Japan, May 9 - 11, 2018...

PREFACE: 9th National Symposium on Polymeric Materials (NSPM 2009)

Science.gov (United States)

Ali, Aidy; Salit, Sapuan

2010-07-01

NSPM 2009 is the formal proceedings of the 9th National Symposium on Polymeric Materials held in Residence Hotel Uniten Bangi on 14-16 December 2009. It is also organised with The Plastics and Rubber Institute Malaysia PRIM. The symposium proceedings consists of 94 papers covering a large number of issues on experimental and analytical studies of polymeric materials. The objectives of the symposium are to review the state-of-the art, present and latest findings and exchange ideas among engineers, researchers and practitioners involved in this field. We strongly hope the outcomes of this symposium will stimulate and enhanced the progress of experimental and analytical studies on polymeric materials as well as contribute to the fundamental understanding in related fields. After careful refereeing of all manuscripts, 15 papers were selected for publications in this issue. Another 20 papers were selected for publication in Pertanika Journal of Science and Technology (PJST). The content of the material and its rapid dissemination was considered to be more important than its form. We are grateful to all the authors for their papers and presentations in this symposium. They are also the ones who help make this symposium possible through their hard work in the preparation of the manuscripts. We would also like to offer our sincere thanks to all the invited speakers who came to share their knowledge with us. We would also like to acknowledge the untiring efforts of the reviewers, research assistants and students in meeting deadlines and for their patience and perseverance. We are indeed honoured to associate this event with Department of Mechanical and Manufacturing, and Faculty of Engineering, Universiti Putra Malaysia. Finally, we appreciate the sponsor support provided by Faculty of Engineering, The Plastics and Rubber Institute Malaysia (PRIM) and PETRONAS Malaysia. Thank you all. Editors: Aidy Ali and S M Sapuan

File list: InP.Bld.50.AllAg.Th17 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available InP.Bld.50.AllAg.Th17 mm9 Input control Blood Th17 SRX288138,SRX495621,SRX288137,SR...X220933,SRX172342,SRX1328057,SRX1328056 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/InP.Bld.50.AllAg.Th17.bed ...

IntCal13 and Marine13 Radiocarbon Age Calibration Curves 0–50,000 Years cal BP

NARCIS (Netherlands)

Reimer, Paula J.; Bard, Edouard; Bayliss, Alex; Beck, J. Warren; Blackwell, Paul G.; Bronk Ramsey, Christopher; Buck, Caitlin E.; Cheng, Hai; Edwards, R. Lawrence; Friedrich, Michael; Grootes, Pieter M.; Guilderson, Thomas P.; Haflidason, Haflidi; Hajdas, Irka; Hatté, Christine; Heaton, Timothy J.; Hoffmann, Dirk L.; Hogg, Alan G.; Hughen, Konrad A.; Kaiser, K. Felix; Kromer, Bernd; Manning, Sturt W.; Niu, Mu; Reimer, Ron W.; Richards, David A.; Scott, E. Marian; Southon, John R.; Staff, Richard A.; Turney, Christian S.M.; Plicht, Johannes van der; Reimer, Paula J.

2013-01-01

The IntCal09 and Marine09 radiocarbon calibration curves have been revised utilizing newly available and updated data sets from C-14 measurements on tree rings, plant macrofossils, speleothems, corals, and foraminifera. The calibration curves were derived from the data using the random walk model

Creating Profiles from User Network Behavior

Science.gov (United States)

2013-09-01

We varied the m-estimate in Naïve Bayes, m for pruning in Learning Tree, and how many k nearest neighbors to select from in KNN, before settling on the...N. Taft, “The cubicle vs. the coffee shop: behavioral modes in enterprise end-users,” in Proc. of the 9th Int. Conf. on Passive and Active Network

Current status of the ParInt package for parallel multivariate integration

International Nuclear Information System (INIS)

Doncker, E. de; Kaugars, K.; Cucos, L.; Zanny, R.

2002-01-01

The ParInt project focuses on the development of parallel algorithms and software for the computation of multi-variate integrals. We will give an overview of the contents and capabilities of the package. Our objective has been to provide the end-user with state of the art problem solving power. This has required work in a number of areas, including the fundamental numerical techniques, strategies for parallelization, user interfaces for general use and specific applications, and visualization of computations to analyze the mutual influences of problem characteristics and algorithm behavior. Furthermore, the integration of all the above into a versatile set of tools is aimed toward an efficient use of the available parallel or distributed computer resources. (author)

11th AINSE Plasma Physics Conference 1977, 7th and 8th February, 1977, Lucas Heights, NSW (Australia), 9th February, 1977, University of Sydney. Abstracts of Papers 1-54

Energy Technology Data Exchange (ETDEWEB)

Walsh, C. J. [ed.

1977-02-15

Abstracts of papers 1-54 scheduled for oral presentation at the 11th AINSE Plasma Physics Conference are included. No introductory or summary information is provided. Each page consists of the title, authors, organization affiliation, and abstract.

L'initiative Samdrup Jongkhar, un modèle de développement intégré ...

International Development Research Centre (IDRC) Digital Library (Canada)

La Samdrup Jongkhar Initiative est un projet que la société civile a lancé dans le district du même nom, dans le but de favoriser un développement écologiquement responsable, en harmonie avec la philosophie holistique du Bhoutan qui vise à intégrer idéaux sociaux, économiques, culturels et environnementaux.

The Int7G24A variant of transforming growth factor-beta receptor type I is a risk factor for colorectal cancer in the male Spanish population: a case-control study

International Nuclear Information System (INIS)

Castillejo, Adela; Guillén-Ponce, Carmen; Carrato, Alfredo; Soto, José-Luís; Mata-Balaguer, Trinidad; Guarinos, Carla; Castillejo, María-Isabel; Martínez-Cantó, Ana; Barberá, Víctor-Manuel; Montenegro, Paola; Ochoa, Enrique; Lázaro, Rafael

2009-01-01

The Int7G24A variant of transforming growth factor-beta receptor type I (TGFBR1) has been shown to increase the risk for kidney, ovarian, bladder, lung and breast cancers. Its role in colorectal cancer (CRC) has not been established. The aims of this study were to assess the association of TGFBR1*Int7G24A variant with CRC occurrence, patient age, gender, tumour location and stage. We performed a case-control study with 504 cases of sporadic CRC; and 504 non-cancerous age, gender and ethnically matched controls. Genotyping analysis was performed using allelic discrimination assay by real time PCR. The Int7G24A variant was associated with increased CRC incidence in an additive model of inheritance (P for trend = 0.005). No significant differences were found between Int7G24A genotypes and tumour location or stage. Interestingly, the association of the Int7G24A variant with CRC risk was significant in men (odds ratio 4.10 with 95% confidence intervals 1.41-11.85 for homozygous individuals; P for trend = 0.00023), but not in women. We also observed an increase in susceptibility to CRC for individuals aged less than 70 years. Our data suggest that the Int7G24A variant represents a risk factor for CRC in the male Spanish population

78 FR 64916 - Circular Welded Carbon Steel Pipes and Tubes From Turkey: Final Results of Countervailing Duty...

Science.gov (United States)

2013-10-30

... and Value-Added Tax (VAT) Exemptions Under the Free Zones Law IV. Programs Determined To Not Be Used... Income Tax on Wages and Salaries D. Law 5084: Incentive for Employers' Share in Insurance Premiums E. Law... 5084: Energy Support G. Organized Industrial Zone (OIZ): Exemption From Property Tax H. Corporate...

77 FR 46713 - Circular Welded Carbon Steel Pipes and Tubes From Turkey: Final Results of Countervailing Duty...

Science.gov (United States)

2012-08-06

... Zones Law. X. Customs Duties Exemptions Under the Free Zones Law. Y. Value-Added Tax Exemptions Under.... Short-Term Pre-Shipment Rediscount Program. F. Law 5084: Withholding of Income Tax on Wages and Salaries... Land. I. Law 5084: Energy Support. J. OIZ: Exemption from Property Tax. II. Programs Determined To not...

Report on the 9th workshop on the innovative water reactor for flexible fuel cycle

International Nuclear Information System (INIS)

Ishikawa, Nobuyuki; Kobayashi, Noboru; Okubo, Tsutomu; Uchikawa, Sadao

2006-07-01

The research on Innovative Water Reactor for Flexible Fuel Cycle (FLWR) has been performed in JAEA for the development of future innovative reactor. The workshop on FLWRs has been held every year since 1998 aiming at information exchange with other organizations such as universities, laboratories, utilities and vendors. The 9th workshop was held on March 1, 2006 under the joint auspices of JAEA and North Kanto and Kanto-Koetsu branches of Atomic Energy Society of Japan with 64 participants. The workshop began with presentation entitled 'Activities on Nuclear Science and Engineering Research and Collaboration with Industry in JAEA', followed by presentations entitled 'Progress of Research and Development on FLWR' and 'On Final Report of Feasibility Study (phase 2) on Commercialized FBR Cycle Systems'. Then two lectures followed: 'Core and Fuel Design on Super Light Water Reactor' by Tokyo University and 'Recent trends on the Development of Next Generation Nuclear Reactor' by Institute of Applied Energy. This report summarizes the lectures of the workshop. (author)

Proceedings: 9th World Congress on Preventive Dentistry (WCPD): "Community Participation and Global Alliances for Lifelong Oral Health for All," Phuket, Thailand, September 7-10, 2009

DEFF Research Database (Denmark)

Clarkson, J; Watt, R G; Rugg-Gunn, A J

2010-01-01

Information is presented about the 9th World Congress on Preventive Dentistry which was hosted by the International Association for Dental Research in Phuket, Thailand on September 7-10, 2009. The conference's theme, "Community Participation and Global Alliances for Lifelong Oral Health for All...

Intégration des TIC dans la gouvernance locale au Sénégal | IDRC ...

International Development Research Centre (IDRC) Digital Library (Canada)

Intégration des TIC dans la gouvernance locale au Sénégal. Ce projet s'inscrit dans le contexte de la mise en oeuvre du plan d'action du Somment mondial sur la société de l'information (SMSI). Ce plan met l'accent entre autres sur la nécessité d'un partenariat public-privé pour permettre aux collectivités africaines un ...

Gestion intégrée de l'eau urbaine et rurale pour une adaptation ...

International Development Research Centre (IDRC) Digital Library (Canada)

Ce projet de recherche permettra à deux villes indiennes de taille moyenne et à leurs bassins de passer à une approche de gestion de l'eau intégrée et résistante aux changements climatiques, ce qui assurera une meilleure sécurité hydrique aux résidents. Manque de sécurité hydrique en Inde Les villes de l'Asie du Sud ...

Endocytosis‒Mediated Invasion and Pathogenicity of Streptococcus agalactiae in Rat Cardiomyocyte (H9C2)

OpenAIRE

Pooja, Sharma; Pushpanathan, Muthuirulan; Gunasekaran, Paramasamy; Rajendhran, Jeyaprakash

2015-01-01

Streptococcus agalactiae infection causes high mortality in cardiovascular disease (CVD) patients, especially in case of setting prosthetic valve during cardiac surgery. However, the pathogenesis mechanism of S. agalactiae associate with CVD has not been well studied. Here, we have demonstrated the pathogenicity of S. agalactiae in rat cardiomyocytes (H9C2). Interestingly, both live and dead cells of S. agalactiae were uptaken by H9C2 cells. To further dissect the process of S. agalactiae int...

Radioimmunoassay for Lys8, Asn9, neurotensin 8-13: tissue and subcellular distribution of immunoreactivity in chickens

International Nuclear Information System (INIS)

Carraway, R.E.; Ruane, S.E.; Ritsema, R.S.

1983-01-01

A sensitive and specific radioimmunoassay (RIA) for Lys8, Asn9, neurotensin 8-13 (LANT-6) has been developed which utilizes 125I-labeled LANT-6 and rabbit antisera raised towards conjugates of synthetic LANT-6 and bovine thyroglobulin. The antiserum described (TG-22) allows the detection of ca 100 fmol of LANT-6 and crossreacts less than 0.01% with chicken or bovine NT. Dose-response relationships for the native (chicken) and synthetic peptides were indistinguishable. Using this assay the distribution of immunoreactive LANT-6 (iLANT-6) through various tissues of the chicken was studied and compared with that of chicken NT (iNT) determined by RIA. Both iNT and ILANT-6 were found primarily in the brain and gastrointestinal tract, however, their regional distributions were found to differ. Subcellular distribution studies in homogenates of chicken brain indicated that both iNT and iLANT-6 were associated with synaptosome-like and vesicle-like particles. In homogenates of small intestine, pancreas and colon iNT and iLANT-6 appeared to be within osmotically sensitive, sedimentable particles. Analyses using high pressure liquid chromatography established that chicken iLANT-6 co-eluted with the synthetic peptide and that similar substances were present in extracts of rat brain and intestine. These results are consistent with ''messenger' roles for these peptides

MicroRNAs regulate T-cell production of interleukin-9 and identify hypoxia-inducible factor-2α as an important regulator of T helper 9 and regulatory T-cell differentiation.

Science.gov (United States)

Singh, Yogesh; Garden, Oliver A; Lang, Florian; Cobb, Bradley S

2016-09-01

MicroRNAs (miRNAs) regulate many aspects of helper T cell (Th) development and function. Here we found that they are required for the suppression of interleukin-9 (IL-9) expression in Th9 cells and other Th subsets. Two highly related miRNAs (miR-15b and miR-16) that we previously found to play an important role in regulatory T (Treg) cell differentiation were capable of suppressing IL-9 expression when they were over-expressed in Th9 cells. We used these miRNAs as tools to identify novel regulators of IL-9 expression and found that they could regulate the expression of Epas1, which encodes hypoxia-inducible factor (HIF)-2α. HIF proteins regulate metabolic pathway usage that is important in determining appropriate Th differentiation. The related protein, HIF-1α enhances Th17 differentiation and inhibits Treg cell differentiation. Here we found that HIF-2α was required for IL-9 expression in Th9 cells, but its expression was not sufficient in other Th subsets. Furthermore, HIF-2α suppressed Treg cell differentiation like HIF-1α, demonstrating both similar and distinct roles of the HIF proteins in Th differentiation and adding a further dimension to their function. Ironically, even though miR-15b and miR-16 suppressed HIF-2α expression in Treg cells, inhibiting their function in Treg cells did not lead to an increase in IL-9 expression. Therefore, the physiologically relevant miRNAs that regulate IL-9 expression in Treg cells and other subsets remain unknown. Nevertheless, the analysis of miR-15b and miR-16 function led to the discovery of the importance of HIF-2α so this work demonstrated the utility of studying miRNA function to identify novel regulatory pathways in helper T-cell development. © 2016 John Wiley & Sons Ltd.

Proceedings of the 9th workshop on the mass of the electron neutrino

International Nuclear Information System (INIS)

Yasumi, Shinjiro

1984-03-01

The 9th workshop on the mass of electron neutrinos was held at KEK, Japan. The experimental studies concerning the M-shell of Dy atoms for the measurement of the mass of electron neutrinos were presented at the workshop. The reports included in this proceedings concern windowless Si(Li) detectors, the irradiation technique to make Ho-163 radioactive sources, high purity Ho-163 sources, the M X-ray spectra of rare earth atoms, the study on the M-shell of Dy atoms by using monochromatic X-ray from the KEK PF (Photon Factory), the absolute measurement of photon beam flux, the angular distribution of M X-ray accompanying the photoelectric effect caused by linearly polarized photons, the X-ray spectrum around the 5p to 3s peak accompanying the decay of Ho-163, and the data of nuclear matrix elements of the electron capture decay of Ho-163. The reports presented at the previous workshop are also included in this proceedings. They concern the theoretical calculation of the M X-ray spectrum of Dy, the mass measurement of electron neutrinos, the X-ray spectrum of Ho-163 sources, the amount of Dy-164 contained in Ho-163 samples, and the isotope dilution mass spectrometry. (Kato, T.)

Intégration régionale et politique des outre-mers

Directory of Open Access Journals (Sweden)

Didier Benjamin

1999-06-01

Full Text Available Grâce à ses outre-mers, qui lui apportent 96% de sa zone économique exclusive, la France dispose du troisième domaine maritime du monde et assure une présence sur tous les océans. Cependant, les outre-mers ne jouent plus qu'un rôle mineur dans la politique des océans. Ce paradoxe s'explique en partie par les difficultés qu'ils rencontrent à s'insérer dans les échanges internationaux et à s'intégrer aux organisations régionales. Les différences de niveaux de développement socioéconomique avec les pays voisins contribuent à isoler les outre-mers dans leur environnement immédiat.

The Int7G24A variant of transforming growth factor-beta receptor type I is a risk factor for colorectal cancer in the male Spanish population: a case-control study

Directory of Open Access Journals (Sweden)

Lázaro Rafael

2009-11-01

Full Text Available Abstract Background The Int7G24A variant of transforming growth factor-beta receptor type I (TGFBR1 has been shown to increase the risk for kidney, ovarian, bladder, lung and breast cancers. Its role in colorectal cancer (CRC has not been established. The aims of this study were to assess the association of TGFBR1*Int7G24A variant with CRC occurrence, patient age, gender, tumour location and stage. Methods We performed a case-control study with 504 cases of sporadic CRC; and 504 non-cancerous age, gender and ethnically matched controls. Genotyping analysis was performed using allelic discrimination assay by real time PCR. Results The Int7G24A variant was associated with increased CRC incidence in an additive model of inheritance (P for trend = 0.005. No significant differences were found between Int7G24A genotypes and tumour location or stage. Interestingly, the association of the Int7G24A variant with CRC risk was significant in men (odds ratio 4.10 with 95% confidence intervals 1.41-11.85 for homozygous individuals; P for trend = 0.00023, but not in women. We also observed an increase in susceptibility to CRC for individuals aged less than 70 years. Conclusion Our data suggest that the Int7G24A variant represents a risk factor for CRC in the male Spanish population.

The Th1/Th2/Th17/Treg paradigm induced by stachydrine hydrochloride reduces uterine bleeding in RU486-induced abortion mice.

Science.gov (United States)

Li, Xia; Wang, Bin; Li, Yuzhu; Wang, Li; Zhao, Xiangzhong; Zhou, Xianbin; Guo, Yuqi; Jiang, Guosheng; Yao, Chengfang

2013-01-09

The Th1/Th2/Th17/Treg paradigm plays an important role in achieving maternal-fetal immunotolerance and participates in RU486-induced abortion. Excessive uterine bleeding is the most common side effect of RU486-induced abortion; however, its etiopathogenesis has not been fully understood. Therefore, elucidating the correlation between the Th1/Th2/Th17/Treg paradigm and the volume of uterine bleeding may offer novel therapeutic target for reducing uterine bleeding in RU486-induced abortion. Leonurus sibiricus has been used in clinics to reduce postpartum hemorrhage with low toxicity and high efficiency; however, the effective constituents and therapeutic mechanism have not been described. Stachydrine hydrochloride is the main constituent of L. sibiricus, therefore L. sibiricus is regarded as a candidate for reducing uterine bleeding in RU486-induced abortion mice by regulating the Th1/Th2/Th17/Treg paradigm. The purpose of this study was to determine the Th1/Th2/Th17/Treg paradigm in uterine bleeding of RU486-induced abortion mice and to elucidate the immunopharmacologic effects of stachydrine hydrochloride on inducing the Th1/Th2/Th17/Treg paradigm in reducing the uterine bleeding volume in RU486-induced abortion mice. To investigate the Th1/Th2/Th17/Treg paradigm in uterine bleeding during RU486-induced abortion mice, pregnant BALB/c mice were treated with high- and low-dose RU486 (1.5mg/kg and 0.9 mg/kg, respectively), and the serum progesterone (P(4)) protein level, uterine bleeding volume, and proportions of Th1/Th2/Th17/Treg cells in mice at the maternal-fetal interface were detected by ELISA assay, alkaline hematin photometric assay, and flow cytometry, respectively. To determine the regulatory effect of stachydrine hydrochloride on the Th1/Th2/Th17/Treg paradigm in vitro, splenocytes of non-pregnant mice were separated and treated with P(4,) RU486, and/or stachydrine hydrochloride (10(-5)M, 10(-4)M, and 10(-3)M, respectively). The proportions of Th1/Th2/Th17

Predicting the Attitudes and Self-Esteem of the Grade 9th Lower Secondary School Students towards Mathematics from Their Perceptions of the Classroom Learning Environment

Science.gov (United States)

Tran, Van Dat

2012-01-01

This study reports the validity of the hypothesis that students' perceptions of the learning environment of mathematics classroom may predict their attitudes and self-esteem towards mathematics. It examines data from 487 grade 9th students from 14 mathematics classes in 7 Vietnamese lower secondary schools to identify how students' perceptions of…

Muon reconstruction efficiency and momentum resolution of the ATLAS experiment in proton-proton collisions at √s = 7 TeV in 2010.

Czech Academy of Sciences Publication Activity Database

Aad, G.; Abajyan, T.; Abbott, B.; Böhm, Jan; Chudoba, Jiří; Hejbal, Jiří; Jakoubek, Tomáš; Kepka, Oldřich; Kupčo, Alexander; Kůs, Vlastimil; Lokajíček, Miloš; Lysák, Roman; Marčišovský, Michal; Mikeštíková, Marcela; Myška, Miroslav; Němeček, Stanislav; Růžička, P.; Schovancová, J.; Šícho, Petr; Staroba, Pavel; Svatoš, Michal; Taševský, Marek; Tic, Tomáš; Vrba, Václav

2014-01-01

Roč. 74, č. 9 (2014), s. 1-32 ISSN 1434-6044 R&D Projects: GA MŠk(CZ) LG13009 Institutional support: RVO:68378271 Keywords : p p * scattering * Z0 * leptonic decay * performance * muon * particle identification * momentum resolution * efficiency * ATLAS * CERN LHC Coll * Monte Carlo Subject RIV: BF - Elementary Particles and High Energy Physics Impact factor: 5.084, year: 2014

Coordination polyhedra ThOn in crystal structure

International Nuclear Information System (INIS)

Shevchenko, A.P.; Serezhkin, V.N.; Mikhajlov, Yu.N.

2000-01-01

The environment peculiarities of Th(4) 107 atoms in 93 oxygen-containing compounds were studied using the Voronoi-Dirichlet (VD) polyhedrons. It was determined that in case of high coordination number (CN ≥ 6) of thorium atoms the volume of their VD polyhedrons did not practically depend on CN Th and constituted 11.9 (4) A 3 . The volume of the classical coordination polyhedrons, namely, ThO n , ZrO n and U 4 O n ones, was determined to depend linearly on the coordination number. It was shown that in case CN [ru

Predicción de volatilidad de la rentabilidad diaria del mercado del azúcar y su aplicación en la razón de cobertura

Directory of Open Access Journals (Sweden)

Arody Ortiz Alvarado

2016-03-01

Full Text Available Este trabajo predice la volatilidad de la rentabilidad diaria del precio del azúcar, en el período compren­dido entre 1 de junio de 2011 y el 24 de octubre de 2013. Los datos diarios utilizados fueron los precios del azúcar, del etanol y la tasa de cambio de la moneda de Brasil (Real en dólares. Se usaron modelos multivariados de volatilidad autoregresiva condicional generalizada. A partir de la predicción de los precios del azúcar se calcula la razón de cobertura de mínima varianza. Los resultados muestran, que la razón de cobertura es 0.37, esto significa que, si un productor adverso al riesgo, que tiene la intención de eliminar un porcentaje de la volatilidad de la rentabilidad diaria del mercado mundial del azúcar, y espera vender 25 contratos de azúcar, cada uno de ellos de 50,84 toneladas (1.271 toneladas, el número de contratos optimo tomando cobertura a futuro será 9 y el número de contratos sin tomar cobertura (de contado será 16. This work predicts the volatility of the daily profitability of sugar prices for the period between 1 of June 2001 and 24th of October 2013. The daily data collected covered sugar, ethanol and the Brazilian Real and USD exchange rate information. The models used were multivariate generalized conditional autoregressive volatility. Parting from the sugar price prediction, the coverage ratio for the minimum variance is calculated. Results show that the coverage ratio is 0.37. This means that in the case of a risk adverse producer that wants to eliminate a percentage of volatility of the world´s sugar market daily profitability, and expects to sell 25 sugar contracts, 50,84 tons each, (1,271 tons, the optimal number of contracts with future cover­age will be 9 and the number of contracts without coverage (spot price will be 16

Survey of Oral Health Awareness in Neuchâtel 9th Graders.

Science.gov (United States)

Neuhaus, Klaus W; Müller, Magali E; Lussi, Adrian

The oral health habits of pupils had not yet been analyzed for the canton of Neuchâtel. A questionnaire was provided to 9th grade high school pupils (final year) of the three schools located in the Neuchâtel area to asses both oral health knowledge and habits in this connection. The average age was 15.5±0.8 years, and 78.1% of the questionnaires were returned. The prophylaxis program was conducted for a total of 4.5 h during pupils’ entire time at school. The results showed that both knowledge and oral health habits could be improved. As a positive outcome, 99% of the pupils brush their teeth before going to bed. Comparisons with similar 10-year-old studies from other cantons (Bern, Vaud) showed major differences in knowledge, for example on the importance of fluoridation. Only 54% of the pupils in Neuchâtel knew that fluoride offers some protection against caries, in spite of the fact that 89% thought that brushing with fluoridated toothpaste protects against caries. Most of the pupils used a fluoridated toothpaste. Furthermore, we found that self-reported sugar consumption was correlated with caries experience, but brushing frequency was not. We recommend introducing a review course for pupils in their last school year, in order to practice interdental cleaning, redefine appropriate, tooth-friendly snacks, and emphasize the importance of regular dental check-ups.

Crystal structures of Th(OH)PO4, U(OH)PO4 and Th2O(PO4)2. Condensation mechanism of M(IV)(OH)PO4 (M= Th, U) into M2O(PO4)2

International Nuclear Information System (INIS)

Dacheux, N.; Clavier, N.; Wallez, G.; Quarton, M.

2007-01-01

Three new crystal structures, isotypic with β-Zr 2 O(PO 4 ) 2 , have been resolved by the Rietveld method. All crystallize with an orthorhombic cell (S.G.: Cmca) with a = 7.1393(2) Angstroms, b = 9.2641(2) Angstroms, c 12.5262(4) Angstroms, V = 828.46(4) (Angstroms) 3 and Z = 8 for Th(OH)PO 4 ; a = 7.0100(2) Angstroms, b = 9.1200(2) Angstroms, c = 12.3665(3) Angstroms, V 790.60(4) (Angstroms) 3 and Z = 8 for U(OH)PO 4 ; a 7.1691(3) Angstroms, b 9.2388(4) Angstroms, c = 12.8204(7) Angstroms, V 849.15(7) (Angstroms) 3 and Z = 4 for Th 2 O(PO 4 ) 2 . By heating, the M(OH)PO 4 (M Th, U) compounds condense topotactically into M 2 O(PO 4 ) 2 , with a change of the environment of the tetravalent cation that lowers from 8 to 7 oxygen atoms. The lower stability of Th 2 O(PO 4 ) 2 compared to that of U 2 O(PO 4 ) 2 seems to result from this unusual environment for tetravalent thorium. (authors)

The Relationship of Grade Span in 9th Grade to Math Achievement in High School

Science.gov (United States)

West, John; Miller, Mary Lou; Myers, Jim; Norton, Timothy

2015-01-01

Purpose, Scope, and Method of Study: The purpose of this study was to determine if a correlation exists between grade span for ninth grade and gains in math achievement test scores in 10th grade and 12th grade. A quantitative, longitudinal, correlational research design was employed to investigate the research questions. The population was high…

A CMOS-MEMS clamped–clamped beam displacement amplifier for resonant switch applications

Science.gov (United States)

Liu, Jia-Ren; Lu, Shih-Chuan; Tsai, Chun-Pu; Li, Wei-Chang

2018-06-01

This paper presents a micromechanical clamped–clamped beam (CC-beam) displacement amplifier based on a CMOS-MEMS fabrication process platform. In particular, a 2.0 MHz resonant displacement amplifier composed of two identical CC-beams coupled by a mechanical beam at locations where the two beams have mismatched velocities exhibits a larger displacement, up to 9.96×, on one beam than that of the other. The displacement amplification prevents unwanted input impacting—the structure switches only to the output but not the input—required by resonant switch-based mechanical circuits (Kim et al 2009 22nd IEEE Int. Conf. on Micro Electro Mechanical Systems; Lin et al 2009 15th Int. Conf. on Solid-State Sensors, Actuators, & Microsystems (TRANSDUCERS’09) Li et al 2013 17th Int. Conf. on Solid-State Sensors, Actuators, & Microsystems (TRANSDUCERS’13)). Compared to a single CC-beam displacement amplifier, theory predicts that the displacement amplifying CC-beam array yields a larger overall output displacement for displacement gain beyond 1.13 thanks to the preserved input driving force. A complete analytical model predicts the resultant stiffness and displacement gain of the coupled CC-beam displacement amplifier that match well with finite element analysis (FEA) prediction and measured results.

Environmental Pollution in five floors (5th to 9th) Resulting from the use of Depleted Uranium Weaponry in the Al-Tahreer Tower Building

International Nuclear Information System (INIS)

Ameen, N.H; Al-ghirrawy, M.A; Kadhim, H.H

2014-01-01

The goals of this study include measuring the increase in radioactivity and removal the contamination regions to protect the population and the environment resulting from bombing the Al-Tahreer Tower Building (the Turkish restaurant previously) by the depleted uranium bullets through direct measurement and sampling of soil from five floors (Fifth,Sixth,Seventh,Eighth,and Ninth) of the building, which contains fourteen floors in addition to basement by using different types of portable monitoring equipment s.The results of radiological surveys by using the portable monitor (CAB) indicated the presence of contaminated soil reached to 55 c/sec, and small particles of depleted uranium shells has very high levels of contamination reached to 70 c /sec ,while the background level is (0.5 c/sec) ,and the higher exposure rates is 55 μR/hr when the portable monitor (Ludlum) put on the contaminated regions approximately on distance 0.5 cm), where the natural background level is 9 μR/hr in the floors of the building.The radiological analyses of the collected soil samples were done in the laboratory of the center of Radiological Researches in the Ministry of sciences and Technology by using gamma spectrometry (which contains High- purity Germanium Detector) with a efficiency of 40% and resolution 2 keV for Energy, 1.33Mev, collection, preparations and tests of soil samples were all done according to IAEA.The laboratory results indicated the presence of high concentrations of the isotopes Th-234 (1550.1) Bq/kg, and Pa-234 m (1394.8) in the soil samples taken from the floors while the concentrations of Th-234 and Pa-234 m in natural background levels are (nearly 40, nil) Bq/Kg respectively which is a clear indication of the presence of high concentrations an isotope of uranium - 238 as they are supposed to be in equilibrium radiation.

230,232Th in milk, meat, and grain in Korea

International Nuclear Information System (INIS)

Lin, Xiujing; Choi, Minseok; Kim, Wan; Kang, Heedong; Doh, Sihhong; Kim, Dosung; Kim, Changkyu

2004-01-01

The concentrations of natural radioisotopes 230 Th and 232 Th in Korean foods were measured by the method of calcium oxalate co-precipitation in addition to the conventional anion-exchange method and alpha spectroscopic measurement. The 230 Th concentrations (mBq/kg-fresh) in Korean foods were found to be as follows: milk 0.14-2.45, pork 2.98-8.97, beef 1.94-9.80, chicken 1.22-13.0, rice 0.43-2.35, wheat 0.53-14.4, and soybeans, 8.44-91.6. The 232 Th concentrations (mBq/kg-fresh) in Korean foods were found to be as follows: milk 0.01-2.46, pork 0.28-9.32, beef 1.02-5.34, chicken 0.56-4.98, rice 0.32-2.54, wheat 0.53-20.0, and soybeans, 2.30-42.2. The annual internal dose of Th was also estimated. The annual internal dose of 230 Th and 232 Th in milk was about 0.006 μSv/yr and much lower than that of other countries because of the low intake of milk in Korea compared to other countries. The annual internal dose of 230 Th and 232 Th in the rice was about 0.043 μSv/yr and highest because rice is the staple food of Koreans. (author)

7th to 9th grade obese adolescents' perceptions about obesity in Tamaulipas, Mexico.

Science.gov (United States)

de la Luz Martínez-Aguilar, Ma; Flores-Peña, Yolanda; de las Mercedes Rizo-Baeza, Ma; Aguilar-Hernández, Rosa Ma; Vázquez-Galindo, Laura; Gutiérres-Sánchez, Gustavo

2010-01-01

The objective was to explore obese adolescents perceptions about obesity among students in the seventh to ninth grade of a public school in Tamaulipas, Mexico. This is a qualitative study. Participants were 24 adolescents with a body mass index equal to or greater than the 95th percentile. Semistructured interviews were conducted until data saturation was reached and the meaning was understood. The adolescents defined obesity according to standards of measurement. They identified the hereditary factor as the main obesity cause, tended to underestimate obesity and had low self-esteem. They reported problems to do physical exercise and get clothes in order to improve their image, and feel rejected by their peers in school. It was identified that these adolescents have psychological defense mechanisms against obesity and that some of them are making efforts to lose weight. Obesity entails social and psychological health implications for persons suffering from this problem. Interventions should be put in practice.

Création d'outils pour la mesure de l'intégration des technologies de ...

International Development Research Centre (IDRC) Digital Library (Canada)

En collaborant avec les ministères de l'Éducation de la Colombie, du Mexique, du Pérou et de l'Uruguay, les chercheurs élaboreront des méthodologies communes et des indicateurs pertinents localement en vue de surveiller et de mesurer l'intégration des TIC en classe. Les résultats obtenus fourniront aux décideurs les ...

Intégration et coopération régionales en Afrique de l'Ouest | CRDI ...

International Development Research Centre (IDRC) Digital Library (Canada)

Épuisé. 406 pages. e-ISBN : 1552502988. Téléchargez le PDF · Téléchargez le cyberlivre. Cet ouvrage constate l'échec de l'intégration et de la coopération régionales en Afrique de l'Ouest et en analyse les raisons. Simultanément, il explore certaines des options permettant d'envisager la revitalisation de ce processus.

8th International Symposium on Unsteady Aerodynamics and Aeroelasticity of Turbomachines

CERN Document Server

1998-01-01

Twenty-one years have passed since the first symposium in this series was held in Paris (1976). Since then there have been meetings in Lausanne (1980), Cambridge (1984), Aachen (1987), Beijing (1989), Notre Dame (1991) and Fukuoka (1994). During this period a tremendous development in the field of unsteady aerodynamics and aeroelasticity in turbomachines has taken place. As steady-state flow conditions become better known, and as blades in the turbomachine are constantly pushed towards lower weight, and higher load and efficiency, the importance of unsteady phenomena appear more clearly. th The 8 Symposium was, as the previous ones, of high quality. Furthermore, it presented the audience with the latest developments in experimental, numerical and theoretical research. More papers than ever before were submitted to the conference. As the organising committee wanted to preserve the uniqueness of the symposium by having single sessions, and thus mingle speakers and audience with different backgrounds in this int...

Intrinsic atopic dermatitis shows similar TH2 and higher TH17 immune activation compared with extrinsic atopic dermatitis.

Science.gov (United States)

Suárez-Fariñas, Mayte; Dhingra, Nikhil; Gittler, Julia; Shemer, Avner; Cardinale, Irma; de Guzman Strong, Cristina; Krueger, James G; Guttman-Yassky, Emma

2013-08-01

Atopic dermatitis (AD) is classified as extrinsic and intrinsic, representing approximately 80% and 20% of patients with the disease, respectively. Although sharing a similar clinical phenotype, only extrinsic AD is characterized by high serum IgE levels. Because most patients with AD exhibit high IgE levels, an "allergic"/IgE-mediated disease pathogenesis was hypothesized. However, current models associate AD with T-cell activation, particularly TH2/TH22 polarization, and epidermal barrier defects. We sought to define whether both variants share a common pathogenesis. We stratified 51 patients with severe AD into extrinsic AD (n = 42) and intrinsic AD (n = 9) groups (with similar mean disease activity/SCORAD scores) and analyzed the molecular and cellular skin pathology of lesional and nonlesional intrinsic AD and extrinsic AD by using gene expression (real-time PCR) and immunohistochemistry. A significant correlation between IgE levels and SCORAD scores (r = 0.76, P extrinsic AD. Marked infiltrates of T cells and dendritic cells and corresponding epidermal alterations (keratin 16, Mki67, and S100A7/A8/A9) defined lesional skin of patients with both variants. However, higher activation of all inflammatory axes (including TH2) was detected in patients with intrinsic AD, particularly TH17 and TH22 cytokines. Positive correlations between TH17-related molecules and SCORAD scores were only found in patients with intrinsic AD, whereas only patients with extrinsic AD showed positive correlations between SCORAD scores and TH2 cytokine (IL-4 and IL-5) levels and negative correlations with differentiation products (loricrin and periplakin). Although differences in TH17 and TH22 activation exist between patients with intrinsic AD and those with extrinsic AD, we identified common disease-defining features of T-cell activation, production of polarized cytokines, and keratinocyte responses to immune products. Our data indicate that a TH2 bias is not the sole cause of high Ig

Proceedings of NUCLEAR 2016 the 9th annual international conference on sustainable development through nuclear research and education. Part 3/3

International Nuclear Information System (INIS)

Paraschiv, Irina Maria

2016-01-01

The proceedings of the NUCLEAR 2016 the 9th annual international conference on sustainable development through nuclear research and education held at INR-Pitesti on May, 18-20, contain 81 communications presented in two plenary sessions and three sections addressing the themes of Nuclear energy, Environmental protection and Sustainable development. This section (Part 3/3) is addressing the following items: Section 3.1 Education, training and knowledge management (22 papers); Section 3.2 International cooperation (5 papers); These papers are presented as abstracts in 'Nuclear 2016 - Book of Abstracts', separately processed

« Aménagement numérique en Languedoc-Roussillon. Compte-rendu de la thèse d’Alexandre Schon »

Directory of Open Access Journals (Sweden)

Gabriel Dupuy

2016-05-01

Full Text Available Les recherches concernant l’aménagement des infrastructures numériques sont peu nombreuses en France. Quant aux thèses sur le sujet, elles sont particulièrement rares. Celle d’Alexandre Schon illustre bien les difficultés de cette approche mais elle en montre surtout le grand intérêt. Une première difficulté tient à la définition même des réseaux. A vrai dire, elle n’est pas propre aux télécommunications. Les réseaux de transport comportent aussi ce que les spécialistes appellent une « couche...

Proceedings of the International Association for Development of the Information Society (IADIS) International Conference on Mobile Learning (12th, Vilamoura, Algarve, Portugal, April 9-11, 2016)

Science.gov (United States)

Sánchez, Inmaculada Arnedillo, Ed.; Isaías, Pedro, Ed.

2016-01-01

These proceedings contain the papers of the 12th International Conference on Mobile Learning 2016, which was organized by the International Association for Development of the Information Society, in Vilamoura, Algarve, Portugal, April 9-11, 2016. The Mobile Learning 2016 Conference seeks to provide a forum for the presentation and discussion of…

The 4th Seto congress : Värska, Estonia, 9th of October 1996

Index Scriptorium Estoniae

1996-01-01

IV Seto kongress, 9. okt. 1996, Värska kongressi deklaratsioon; resolutsioon Eesti-Vene piirist; resolutsioon piiri ületamisest (vabast liikumisest), resolutsioon Eesti Vabariigi kodanikest Petseri regioonis, resolutsioon ühinemine kohta Esindamata Rahvaste Organisatsiooniga (ERO)

Elastic, vibration and thermodynamic properties of Cu1‑x Ag x InTe2 (x = 0, 0.25, 0.5, 0.75 and 1) chalcopyrite compounds via first principles

Science.gov (United States)

Zhong, Yuhan; Wang, Peida; Mei, Huayue; Jia, Zhenyuan; Cheng, Nanpu

2018-06-01

CuInTe2 chalcopyrite compound is widely used in the fields of optoelectronics and pyroelectricity, and doping atoms can further improve the physical properties of the CuInTe2 compound. For all we know, this is the first time that the elastic behaviors and lattice dynamical properties of Ag-doped CuInTe2 compounds with the tetragonal system are determined theoretically. The elastic, lattice dynamical and thermal properties of Cu1‑x Ag x InTe2 (x = 0, 0.25, 0.5, 0.75 and 1) compounds have been investigated by using density functional theory. The obtained elastic constants of Cu1‑x Ag x InTe2 compounds indicate that these compounds are mechanically stable and elastic anisotropic. The anisotropy of the {001} plane is more obvious than those of the {100} and {010} planes. Additionally, with increasing Ag doping concentrations, the bulk and shear moduli of Cu1‑x Ag x InTe2 compounds decrease and their toughness improves. The phonon spectra and density of states reveal that Cu (or Ag) atoms in Cu1‑x Ag x InTe2 compounds form chemical bonds with Te atoms, and Cu-Te bonds are gradually replaced by Ag-Te bonds with increasing Ag doping concentration. Vibration modes of Cu1‑x Ag x InTe2 compounds at the {{Γ }} point in the Brillouin zone show that each Cu1‑x Ag x InTe2 (x = 0 and 1) crystal includes five irreducible representations (A1, A2, B1, B2 and E). As for Cu1‑x Ag x InTe2 (x = 0.25, 0.5 and 0.75) compounds, each crystal has three irreducible representations (A, B and E). The atomic displacements of several typical phonon modes in CuInTe2 crystals have been analyzed to deepen the understanding of lattice vibrations in Cu1‑x AgxInTe2 compounds. With increasing Ag doping concentration, the Debye temperatures of Cu1‑x Ag x InTe2 compounds decrease, while their heat capacities increase.

Layer silicates modified with 1,4-bis(3-aminopropyl)piperazine for the removal of Th(IV), U(VI) and Eu(III) from aqueous media

International Nuclear Information System (INIS)

Guerra, Denis L.; Pinto, Alane A.; Viana, Rubia R.; Airoldi, Claudio

2009-01-01

Natural montmorillonite (M) and synthetic kanemite (K) have been functionalized with 1,4-bis(3-aminopropyl)piperazine reacted with methylacrylate to yield new inorganic-organic chelating materials. The original and modified materials were characterized by X-ray diffractometry, textural analysis, SEM and nuclear magnetic nuclei of carbon-13 and silicon-29. The chemically modified clay samples (M-APPMA and K-APPMA) showed modification of its physical-chemical properties including: specific area 45.0 m 2 g -1 (M) to 978.8 m 2 g -1 (M-APPMA) and 23.5 m 2 g -1 (K) to 898.9 m 2 g -1 (K-APPMA). The ability of these materials to remove thorium(IV), uranyl(VI) and europium(III) from aqueous solution was followed by a series of adsorption isotherms, which were fitted to non-linear Sips adsorption isotherm model. To achieve the best adsorption conditions the influence of pH and variation of metal concentration were investigated. The energetic effects (Δ int H o , Δ int G o and Δ int S o ) caused by metal ions adsorption were determined through calorimetric titrations.

Hybrid lentivirus-phiC31-int-NLS vector allows site-specific recombination in murine and human cells but induces DNA damage.

Directory of Open Access Journals (Sweden)

Nicolas Grandchamp

Full Text Available Gene transfer allows transient or permanent genetic modifications of cells for experimental or therapeutic purposes. Gene delivery by HIV-derived lentiviral vector (LV is highly effective but the risk of insertional mutagenesis is important and the random/uncontrollable integration of the DNA vector can deregulate the cell transcriptional activity. Non Integrative Lentiviral Vectors (NILVs solve this issue in non-dividing cells, but they do not allow long term expression in dividing cells. In this context, obtaining stable expression while avoiding the problems inherent to unpredictable DNA vector integration requires the ability to control the integration site. One possibility is to use the integrase of phage phiC31 (phiC31-int which catalyzes efficient site-specific recombination between the attP site in the phage genome and the chromosomal attB site of its Streptomyces host. Previous studies showed that phiC31-int is active in many eukaryotic cells, such as murine or human cells, and directs the integration of a DNA substrate into pseudo attP sites (pattP which are homologous to the native attP site. In this study, we combined the efficiency of NILV for gene delivery and the specificity of phiC31-int for DNA substrate integration to engineer a hybrid tool for gene transfer with the aim of allowing long term expression in dividing and non-dividing cells preventing genotoxicity. We demonstrated the feasibility to target NILV integration in human and murine pattP sites with a dual NILV vectors system: one which delivers phiC31-int, the other which constitute the substrate containing an attB site in its DNA sequence. These promising results are however alleviated by the occurrence of significant DNA damages. Further improvements are thus required to prevent chromosomal rearrangements for a therapeutic use of the system. However, its use as a tool for experimental applications such as transgenesis is already applicable.

Immune influence of pregnancy on human H7N9 infection: a case report

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G. Cui

2015-05-01

Full Text Available Introduction: H7N9 infection has raised serious concerns worldwide. Pregnant women were considered to be at a high risk of influenza infection. Normal pregnancy was dependent on T helper (Th 2 deviation. However, whether pregnancy influences the immune status of influenza H7N9 patients has not been reported. Case report: Here, we reported a case of pregnant woman in the first trimester with H7N9 infection compared with the two non-pregnant female H7N9 patients for clinical features and relevant immunological changes. We found that there were no differences in plasma levels of Th1 and Th2 cytokines between the pregnant and non-pregnant patients, and there was no Th2 deviation in the acute phase. However, the Th2 deviation was recurrent along with the clearance of infection in the H7N9 pregnant patient. Conclusion: These cases highlighted that the pregnant patient infected with H7N9 could induce an effective Th1 immune response equal to that of non-pregnant patients with H7N9 virus infection, although the pregnancy itself could lead to a Th2 deviation. These data suggested that pregnant patients could acquire a similar antiviral response for H7N9 infection versus non-pregnant patients. Keywords: Influenza, H7N9, Pregnancy, Immunologic characteristics, Cytokines

RPA70 depletion induces hSSB1/2-INTS3 complex to initiate ATR signaling

OpenAIRE

Kar, Ananya; Kaur, Manpreet; Ghosh, Tanushree; Khan, Md. Muntaz; Sharma, Aparna; Shekhar, Ritu; Varshney, Akhil; Saxena, Sandeep

2015-01-01

The primary eukaryotic single-stranded DNA-binding protein, Replication protein A (RPA), binds to single-stranded DNA at the sites of DNA damage and recruits the apical checkpoint kinase, ATR via its partner protein, ATRIP. It has been demonstrated that absence of RPA incapacitates the ATR-mediated checkpoint response. We report that in the absence of RPA, human single-stranded DNA-binding protein 1 (hSSB1) and its partner protein INTS3 form sub-nuclear foci, associate with the ATR-ATRIP comp...

AMS 14C measurements for tree-ring samples from Japanese woods from 4c AD to 8c AD

International Nuclear Information System (INIS)

Ozaki, Hiromasa; Sakamoto, Minoru; Imamura, Mineo; Mitsutani, Takumi

2010-01-01

Regional offsets of atmospheric 14 C concentration, as represented by differences from IntCal calibration datasets, are discussed at times in relation to universal use of international radiocarbon calibration curve. In the construction of IntCal, 14 C contents of contemporaneous tree-ring samples from different regions in the northern hemisphere have been used, because the regional differences were indistinguishable from errors of measurements. Nowadays, high-precision 14 C results can be obtained much more easily than before, so more attention should be paid to the possible regional offsets. Most parts of IntCal has been constructed by using 14 C contents of tree-ring samples from woods in high latitude of Europe and North America, which are farthest from Japan in the northern hemisphere. So far, we have measured 14 C contents of tree-ring samples from Japanese wood samples dendrochronologically dated from 11th century BC to 4th century AD in order to investigate regional offset in Japan. Although the obtained results agreed well with IntCal in general, there were some periods when the 14 C contents differ significantly from IntCal. In this paper, we report the new results of AMS 14 C measurement for Japanese tree-ring samples ranging from 4th century AD to 8th century AD. The results show a significant disagreement with IntCal at around 630 AD. Similar difference was indicated by 14 C contents of tree-ring samples from other Japanese woods (Imamura et al., 2007). So it is certain that the regional offset in Japan exists at around 630 AD. (author)

Le label « bateaux d’intérêt patrimonial »

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Herveline Delhumeau

2009-05-01

Full Text Available Le label « bateaux d’intérêt patrimonial » s’inscrit pleinement dans les missions de la Fondation du patrimoine maritime et fluvial qui a pour vocation d’inventorier, de sauvegarder, de préserver et de promouvoir le patrimoine maritime et fluvial national non protégé par l’État. (fig. n°1Figure 1Belote et Re, thonier-chalutier traditionnel, construit en 1957 à Saint-Gilles Croix-de-Vie. Ce bateau est la dernière coque en bois réalisée par le chantier Bénéteau-père. © Fondation du Patrimoine ...

La cohérence dans la mobilisation du capital humain:une illustration de la théorie de l’architecture organisationnelle dans les banques de réseau

OpenAIRE

Christine Marsal

2006-01-01

(VF)S’il est courant d’opposer capital financier et capital humain les organisations mettent en place des mécanismes de coordination afin de faire converger les intérêts des deux catégories de partenaires que sont les salariés et les actionnaires. La théorie de l’architecture organisationnelle permet de fournir un cadre d’analyse pertinent pour rendre compte de ces mécanismes. Dans ce cadre nous pouvons constater la pluralité des mécanismes d’incitation. Parmi eux, les incitations financières...

The Impact of a Teaching-Learning Program Based on a Brain-Based Learning on the Achievement of the Female Students of 9th Grade in Chemistry

Science.gov (United States)

Shabatat, Kawthar; Al-Tarawneh, Mohammed

2016-01-01

This study aimed at recognizing the impact of teaching-learning program based on a brain-based learning on the achievement of female students of 9th grade in chemistry, to accomplish the goal of this study the researchers designed instruments of: instructional plans, pre achievement and past achievement exams to use them for the study-validity and…

Lin- CD34hi CD117int/hi FcεRI+ cells in human blood constitute a rare population of mast cell progenitors.

Science.gov (United States)

Dahlin, Joakim S; Malinovschi, Andrei; Öhrvik, Helena; Sandelin, Martin; Janson, Christer; Alving, Kjell; Hallgren, Jenny

2016-01-28

Mast cells are rare tissue-resident immune cells that are involved in allergic reactions, and their numbers are increased in the lungs of asthmatics. Murine lung mast cells arise from committed bone marrow-derived progenitors that enter the blood circulation, migrate through the pulmonary endothelium, and mature in the tissue. In humans, mast cells can be cultured from multipotent CD34(+) progenitor cells. However, a population of distinct precursor cells that give rise to mast cells has remained undiscovered. To our knowledge, this is the first report of human lineage-negative (Lin(-)) CD34(hi) CD117(int/hi) FcεRI(+) progenitor cells, which represented only 0.0053% of the isolated blood cells in healthy individuals. These cells expressed integrin β7 and developed a mast cell-like phenotype, although with a slow cell division capacity in vitro. Isolated Lin(-) CD34(hi) CD117(int/hi) FcεRI(+) blood cells had an immature mast cell-like appearance and expressed high levels of many mast cell-related genes as compared with human blood basophils in whole-transcriptome microarray analyses. Furthermore, serglycin, tryptase, and carboxypeptidase A messenger RNA transcripts were detected by quantitative reverse transcription-polymerase chain reaction. Altogether, we propose that the Lin(-) CD34(hi) CD117(int/hi) FcεRI(+) blood cells are closely related to human tissue mast cells and likely constitute an immediate precursor population, which can give rise to predominantly mast cells. Furthermore, asthmatics with reduced lung function had a higher frequency of Lin(-) CD34(hi) CD117(int/hi) FcεRI(+) blood mast cell progenitors than asthmatics with normal lung function. © 2016 by The American Society of Hematology.

Beagle: an appropriate experimental animal for extrapolating the organ distribution pattern of Th in humans

International Nuclear Information System (INIS)

Singh, N.P.; Zimmerman, C.J.; Taylor, G.N.; Wrenn, M.E.

1988-01-01

The concentrations and the organ distribution patterns of 228Th, 230Th and 232Th in two 9-y-old dogs of our beagle colony were determined. The dogs were exposed only to background environmental levels of Th isotopes through ingestion (food and water) and inhalation as are humans. The organ distribution patterns of the isotopes in the beagles were compared to the organ distribution patterns in humans to determine if it is appropriate to extrapolate the beagle organ burden data to humans. Among soft tissues, only the lungs, lymph nodes, kidney and liver, and skeleton contained measurable amounts of Th isotopes. The organ distribution pattern of Th isotopes in humans and dog are similar, the majority of Th being in the skeleton of both species. The average skeletal concentrations of 228Th in dogs were 30 to 40 times higher than the average skeletal concentrations of the parent 232Th, whereas the concentration of 228Th in human skeleton was only four to five times higher than 232Th. This suggests that dogs have a higher intake of 228Ra through food than humans. There is a similar trend in the accumulations of 232Th, 230Th and 228Th in the lungs of dog and humans. The percentages of 232Th, 230Th and 228Th in human lungs are 26, 9.7 and 4.8, respectively, compared to 4.2, 2.6 and 0.48, respectively, in dog lungs. The larger percentages of Th isotopes in human lungs may be due simply to the longer life span of humans. If the burdens of Th isotopes in human lungs are normalized to an exposure time of 9.2 y (mean age of dogs at the time of sacrifice), the percent burden of 232Th, 230Th and 228Th in human lungs are estimated to be 3.6, 1.3 and 0.66, respectively. These results suggest that the beagle may be an appropriate experimental animal for extrapolating the organ distribution pattern of Th in humans

CLIMA 2016 - proceedings of the 12th REHVA World Congress

DEFF Research Database (Denmark)

CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 8 + 9 + 10 + 11 + 12 + 13 from track "Sustainable Energy".......CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 8 + 9 + 10 + 11 + 12 + 13 from track "Sustainable Energy"....

Sur la reconnaissance de la compétence exclusive des groupements religieux afin d‘instaurer leur structure intrinsèque et les normes intérieures des relations en tant qu’une des garanties ...

Directory of Open Access Journals (Sweden)

Philip Ryabykh

2012-11-01

SOMMAIRE: 1. Brève histoire de l’affaire – 2. Préambule – 3. Protection de la compétence exclusive des groupements religieux en vue d’instaurer leur structure intrinsèque et les normes intérieures des relations au point de vue de la législation de la Roumanie – 4. Application du principe de l’autonomie des groupements religieux et du principe de l’inadmissibilité d’intervenir pour l’État aux affaires intérieures des groupements religieux – 5. Non-contradiction de la Convention des exigences intérieures des groupements religieux sur la loyauté et la conformité des personnes se trouvant dans les relations de service avec le groupement religieux – 6. Absence des raisons fournies par les faits juridiques suffisantes et justifiant réellement l’assimilation (la mise au même niveau des groupements religieux avec n’importe quelles autres organisations-employeurs dans la sphère de la réglementation des relations de travail – 7. Légalité de l’instauration des restrictions à la création et les activités des syndicats dans les certaines sphères des relations publiques – 8. Compétence de la Roumanie de fixer dans la législation les restrictions à la liberté des syndicats conformément à la sphère des relations religieuses – 9. Signification des résultats du jugement de l’affaire «Syndicat “Le Bon Pasteur” c. Roumanie» (requête 2330/09 pour L’Église Orthodoxe Russe- 10. Conclusion.

Paternité des articles et intérêts concurrents : une analyse des recommandations aux auteurs des journaux traitant de pratique pharmaceutique

Science.gov (United States)

Courbon, Ève; Tanguay, Cynthia; Lebel, Denis; Bussières, Jean-François

2014-01-01

RÉSUMÉ Contexte : La présence d’auteurs honorifiques et fantômes ainsi que les intérêts concurrents représentent des difficultés bien documentées, liées à la publication d’articles scientifiques. Il existe des lignes directrices encadrant la rédaction et la publication de manuscrits scientifiques, notamment celles de l’International Committee of Medical Journal Editors (ICMJE). Objectifs : L’objectif principal de cette étude descriptive et transversale visait à recenser les instructions portant sur la paternité des articles et les intérêts concurrents provenant des recommandations aux auteurs des journaux traitant de pratique pharmaceutique. L’objectif secondaire visait à déterminer des mesures correctrices pour une paternité des articles plus transparente. Méthode : La recherche a débuté par l’identification des journaux traitant de pratique pharmaceutique. La consultation des instructions aux auteurs des journaux a permis ensuite de recenser les recommandations destinées à éviter les problèmes de paternité des articles et d’intérêts concurrents. Finalement, les membres de l’équipe de recherche se sont consultés afin de définir des mesures correctrices possibles à l’intention des chercheurs. Résultats : Des 232 journaux traitant de pharmacie, 33 ont été définis comme traitant de pratique pharmaceutique. Un total de 24 (73 %) journaux mentionnaient suivre la politique de l’ICMJE, 14 (42 %) demandaient aux auteurs de remplir un formulaire de déclaration d’intérêts concurrents au moment de la soumission de l’article, 17 (52 %) présentaient une définition de la qualité d’auteur et 5 (15 %) demandaient de détailler les contributions de chaque auteur. Une grille de 40 critères a été élaborée pour définir l’attribution du statut d’auteur. Conclusion : Moins de la moitié des journaux demandait aux auteurs de transmettre un formulaire de déclaration des intérêts concurrents au moment de la

Delayed Activation Kinetics of Th2- and Th17 Cells Compared to Th1 Cells.

Science.gov (United States)

Duechting, Andrea; Przybyla, Anna; Kuerten, Stefanie; Lehmann, Paul V

2017-09-12

During immune responses, different classes of T cells arise: Th1, Th2, and Th17. Mobilizing the right class plays a critical role in successful host defense and therefore defining the ratios of Th1/Th2/Th17 cells within the antigen-specific T cell repertoire is critical for immune monitoring purposes. Antigen-specific Th1, Th2, and Th17 cells can be detected by challenging peripheral blood mononuclear cells (PBMC) with antigen, and establishing the numbers of T cells producing the respective lead cytokine, IFN-γ and IL-2 for Th1 cells, IL-4 and IL-5 for Th2, and IL-17 for Th-17 cells, respectively. Traditionally, these cytokines are measured within 6 h in flow cytometry. We show here that 6 h of stimulation is sufficient to detect peptide-induced production of IFN-γ, but 24 h are required to reveal the full frequency of protein antigen-specific Th1 cells. Also the detection of IL-2 producing Th1 cells requires 24 h stimulation cultures. Measurements of IL-4 producing Th2 cells requires 48-h cultures and 96 h are required for frequency measurements of IL-5 and IL-17 secreting T cells. Therefore, accounting for the differential secretion kinetics of these cytokines is critical for the accurate determination of the frequencies and ratios of antigen-specific Th1, Th2, and Th17 cells.

Th1-, Th2-, and Th17-associated cytokine expression in hypopharyngeal carcinoma and clinical significance.

Science.gov (United States)

Chen, Xuemei; Wang, Junfu; Wang, Rui; Su, Qinghong; Luan, Junwen; Huang, Haiyan; Zhou, Peng; Liu, Jinsheng; Xu, Xiaoqun

2016-02-01

Th0 cells differentiate into Th1 or Th2 depending on multiple transcription factors acting on specific time points to regulate gene expression. Th17 cells, a subset of IL-17-producing T cells distinct from Th1 or Th2 cells, have been described as key players in inflammation and autoimmune diseases as well as cancer development. In the present study, 53 patients with hypopharyngeal cancer were included. The expression levels of Th1-, Th2- and Th17-associated cytokines in hypopharyngeal cancer tissues and pericarcinoma tissues were detected. The relationship between Th1, Th2, or Th17 infiltration and metastasis was studied. Our results showed that the mRNA and protein expressions of Th1 cytokines were lower, while the expressions of Th2 and Th17 cytokines were higher in tumor tissues, and the intensity of expression was strengthened with clinical stage increasing. Cancer tissues had higher level expressions of Th2 and Th17 cytokines than that of pericarcinoma tissues. From the above data, we speculated that high expressions of Th2- and Th17-associated cytokines in hypopharyngeal carcinoma may contribute to cancer development and metastasis.

Using Static Percentiles of AE9/AP9 to Approximate Dynamic Monte Carlo Runs for Radiation Analysis of Spiral Transfer Orbits

Science.gov (United States)

Kwan, Betty P.; O'Brien, T. Paul

2015-06-01

The Aerospace Corporation performed a study to determine whether static percentiles of AE9/AP9 can be used to approximate dynamic Monte Carlo runs for radiation analysis of spiral transfer orbits. Solar panel degradation is a major concern for solar-electric propulsion because solar-electric propulsion depends on the power output of the solar panel. Different spiral trajectories have different radiation environments that could lead to solar panel degradation. Because the spiral transfer orbits only last weeks to months, an average environment does not adequately address the possible transient enhancements of the radiation environment that must be accounted for in optimizing the transfer orbit trajectory. Therefore, to optimize the trajectory, an ensemble of Monte Carlo simulations of AE9/AP9 would normally be run for every spiral trajectory to determine the 95th percentile radiation environment. To avoid performing lengthy Monte Carlo dynamic simulations for every candidate spiral trajectory in the optimization, we found a static percentile that would be an accurate representation of the full Monte Carlo simulation for a representative set of spiral trajectories. For 3 LEO to GEO and 1 LEO to MEO trajectories, a static 90th percentile AP9 is a good approximation of the 95th percentile fluence with dynamics for 4-10 MeV protons, and a static 80th percentile AE9 is a good approximation of the 95th percentile fluence with dynamics for 0.5-2 MeV electrons. While the specific percentiles chosen cannot necessarily be used in general for other orbit trade studies, the concept of determining a static percentile as a quick approximation to a full Monte Carlo ensemble of simulations can likely be applied to other orbit trade studies. We expect the static percentile to depend on the region of space traversed, the mission duration, and the radiation effect considered.

GeoInt: the first macroseismic intensity database for the Republic of Georgia

Science.gov (United States)

Varazanashvili, O.; Tsereteli, N.; Bonali, F. L.; Arabidze, V.; Russo, E.; Pasquaré Mariotto, F.; Gogoladze, Z.; Tibaldi, A.; Kvavadze, N.; Oppizzi, P.

2018-05-01

Our work is intended to present the new macroseismic intensity database for the Republic of Georgia—hereby named GeoInt—which includes earthquakes from the historical (from 1250 B.C. onwards) to the instrumental era. Such database is composed of 111 selected earthquakes and related 3944 intensity data points (IDPs) for 1509 different localities, reported in the Medvedev-Sponheuer-Karnik scale (MSK). Regarding the earthquakes, the M S is in the 3.3-7 range and the depth is in the 2-36 km range. The entire set of IDPs is characterized by intensities ranging from 2-3 to 9-10 and covers an area spanning from 39.508° N to 45.043° N in a N-S direction and from 37.324° E to 48.500° E in an E-W direction, with some of the IDPs located outside the Georgian border, in the (i) Republic of Armenia, (ii) Russian Federation, (iii) Republic of Turkey, and (iv) Republic of Azerbaijan. We have revised each single IDP and have reevaluated and homogenized intensity values to the MSK scale. In particular, regarding the whole set of 3944 IDPs, 348 belong to the Historical era (pre-1900) and 3596 belong to the instrumental era (post-1900). With particular regard to the 3596 IDPs, 105 are brand new (3%), whereas the intensity values for 804 IDPs have been reevaluated (22%); for 2687 IDPs (75%), intensities have been confirmed from previous interpretations. We introduce this database as a key input for further improvements in seismic hazard modeling and seismic risk calculation for this region, based on macroseismic intensity; we report all the 111 earthquakes with available macroseismic information. The GeoInt database is also accessible online at http://www.enguriproject.unimib.it and will be kept updated in the future.

The point of view of 9th year students of elementary school Simon Jenko Kranj about the use of illegal and legal drugs

OpenAIRE

Debeljak, Dida

2014-01-01

In this degree I deal with the comparison of view-points regarding illegal and legal drugs among pupils in 9th grade. In this research I will focus on tobacco, marihuana, heroin and pills which effect mentality. The empirical part of the thesis in based on these differences. In theoretical part I'm defining the definition of view-points, their characteristics and functions, and I also focus on the source of unfounded view-points. Then I focus on protective and risk factors for using drug...

Emerging contaminants and nutrients synergistically affect the spread of class 1 integron-integrase (intI1) and sul1 genes within stable streambed bacterial communities.

Science.gov (United States)

Subirats, Jèssica; Timoner, Xisca; Sànchez-Melsió, Alexandre; Balcázar, José Luis; Acuña, Vicenç; Sabater, Sergi; Borrego, Carles M

2018-07-01

Wastewater effluents increase the nutrient load of receiving streams while introducing a myriad of anthropogenic chemical pollutants that challenge the resident aquatic (micro)biota. Disentangling the effects of both kind of stressors and their potential interaction on the dissemination of antibiotic resistance genes in bacterial communities requires highly controlled manipulative experiments. In this work, we investigated the effects of a combined regime of nutrients (at low, medium and high concentrations) and a mixture of emerging contaminants (ciprofloxacin, erythromycin, sulfamethoxazole, diclofenac, and methylparaben) on the bacterial composition, abundance and antibiotic resistance profile of biofilms grown in artificial streams. In particular, we investigated the effect of this combined stress on genes encoding resistance to ciprofloxacin (qnrS), erythromycin (ermB), sulfamethoxazole (sul1 and sul2) as well as the class 1 integron-integrase gene (intI1). Only genes conferring resistance to sulfonamides (sul1 and sul2) and intI1 gene were detected in all treatments during the study period. Besides, bacterial communities exposed to emerging contaminants showed higher copy numbers of sul1 and intI1 genes than those not exposed, whereas nutrient amendments did not affect their abundance. However, bacterial communities exposed to both emerging contaminants and a high nutrient concentration (1, 25 and 1 mg L -1 of phosphate, nitrate and ammonium, respectively) showed the highest increase on the abundance of sul1 and intI1 genes thus suggesting a factors synergistic effect of both stressors. Since none of the treatments caused a significant change on the composition of bacterial communities, the enrichment of sul1 and intI1 genes within the community was caused by their dissemination under the combined pressure exerted by nutrients and emerging contaminants. To the best of our knowledge, this is the first study demonstrating the contribution of nutrients on

Layer silicates modified with 1,4-bis(3-aminopropyl)piperazine for the removal of Th(IV), U(VI) and Eu(III) from aqueous media

Energy Technology Data Exchange (ETDEWEB)

Guerra, Denis L., E-mail: dlguerra@iqm.unicamp.br [Chemistry Institute, State University of Campinas, P.O. Box 6154, 13084-971 Campinas, Sao Paulo (Brazil); Pinto, Alane A. [Chemistry Institute, State University of Campinas, P.O. Box 6154, 13084-971 Campinas, Sao Paulo (Brazil); Viana, Rubia R. [Universidade Federal de Mato Grosso, UFMT, Centro de Recursos Minerais, Cuiaba, Mato Grosso 78060 900 (Brazil); Airoldi, Claudio [Chemistry Institute, State University of Campinas, P.O. Box 6154, 13084-971 Campinas, Sao Paulo (Brazil)

2009-11-15

Natural montmorillonite (M) and synthetic kanemite (K) have been functionalized with 1,4-bis(3-aminopropyl)piperazine reacted with methylacrylate to yield new inorganic-organic chelating materials. The original and modified materials were characterized by X-ray diffractometry, textural analysis, SEM and nuclear magnetic nuclei of carbon-13 and silicon-29. The chemically modified clay samples (M-APPMA and K-APPMA) showed modification of its physical-chemical properties including: specific area 45.0 m{sup 2} g{sup -1} (M) to 978.8 m{sup 2} g{sup -1} (M-APPMA) and 23.5 m{sup 2} g{sup -1} (K) to 898.9 m{sup 2} g{sup -1} (K-APPMA). The ability of these materials to remove thorium(IV), uranyl(VI) and europium(III) from aqueous solution was followed by a series of adsorption isotherms, which were fitted to non-linear Sips adsorption isotherm model. To achieve the best adsorption conditions the influence of pH and variation of metal concentration were investigated. The energetic effects ({Delta}{sub int}H{sup o}, {Delta}{sub int}G{sup o} and {Delta}{sub int}S{sup o}) caused by metal ions adsorption were determined through calorimetric titrations.

10th German nuclear law symposium

International Nuclear Information System (INIS)

Koch, H.J.; Rossnagel, A.

2000-01-01

This 10th symposium on nuclear law in Germany was held eight years after the 9th symposium. Due to the change of government after the last general elections, there had been a turnaround in Germany's energy policy. 'Phasing out nuclear energy' was the major strategy of the new Federal Government. The topics of the papers presented at the symposium therefore focus on: a new time frame for NPP shutdown and termination of operating licences; ensuring the safe operation of nuclear power plants for the remaining operating periods; new concepts for radwaste management and ultimate disposal. (orig./CB) [de

Polymorphisms in Th1/Th2 Cytokine Genes, Hormone Replacement Therapy, and Risk of Non-Hodgkin Lymphoma

International Nuclear Information System (INIS)

Zhu, Gongjian; Pan, Dongsheng; Zheng, Tongzhang; Lan, Qing; Chen, Xuezhong; Chen, Yingtai; Kim, Christopher; Bi, Xiaofeng; Holford, Theodore; Boyle, Peter; Leaderer, Brian; Chanock, Stephen J.; Rothman, Nathaniel; Zhang, Yawei

2011-01-01

We conducted a population-based case–control study in Connecticut women to test the hypothesis that genetic variations in Th1 and Th2 cytokine genes modify the relationship between hormone replacement therapy (HRT) and risk of non-Hodgkin lymphoma (NHL). Compared to women without a history of HRT use, women with a history of HRT use had a significantly decreased risk of NHL if they carried IFNGR2 (rs1059293) CT/TT genotypes (OR = 0.5, 95%CI: 0.3–0.9), IL13 (rs20541) GG genotype (OR = 0.6, 95%CI: 0.4–0.9), and IL13 (rs1295686) CC genotype (OR = 0.6, 95%CI: 0.4–0.8), but not among women who carried IFNGR2 CC, IL13 AG/AA, and IL13CT/TT genotypes. A similar pattern was also observed for B-cell lymphoma but not for T-cell lymphoma. A statistically significant interaction was observed for IFNGR2 (rs1059293 P for interaction = 0.024), IL13(rs20541 P for interaction = 0.005), IL13 (rs1295686 P for interaction = 0.008), and IL15RA (rs2296135 P for interaction = 0.049) for NHL overall; IL13 (rs20541 P for interaction = 0.0009), IL13(rs1295686 P for interaction = 0.0002), and IL15RA (rs2296135 P for interaction = 0.041) for B-cell lymphoma. The results suggest that common genetic variation in Th1/Th pathway genes may modify the association between HRT and NHL risk.

U-Th-Ra disequilibria at the Masaya (Nicaragua); Desequilibres U-Th-Ra au Masaya (Nicaragua)

Energy Technology Data Exchange (ETDEWEB)

Sigmarsson, O; Condomines, M [Centre de Recherches Volcanologiques, CNRS URA-10, 63 - Clermont Ferrand (France)

1997-12-31

{sup 238}U-{sup 230}Th-{sup 226}Ra radioactive disequilibria were measured in several basalt samples of the post-caldera flows of the Masaya volcano (Nicaragua). {sup 230}Th/{sup 232}Th ratios are from the highest known in the world (about 2.53) with {sup 230}Th/{sup 238}U ratios close to 1. These exceptionally high isotopic thorium ratios from the Masaya and other neighboring volcanoes (Conception, Cerro Negro, Momotombo) are followed by very high {sup 10}Be/{sup 9}Be ratios (60 10{sup -11} for the 1722 flow). These geochemical characteristics with {delta}{sup 18}O of typical mantle origin (5.55) suggest an influence of the subducted sediments fluids in the magma source. The age of the metasomatism ranges from 10 to 0.3 Ma. Initial {sup 226}Ra/{sup 230}Th ratios measured in four historical flows vary from 1.3 to 1.4 and are anti-correlated with the Th content. These variations are probably linked to the fractionated crystallisation of plagioclase minerals. The initial {sup 226}Ra/Ba ratio remains constant and suggests the existence of a huge stationary magmatic reservoir. This hypothesis is also confirmed by the disproportion between the SO{sub 2} quantity emitted by the volcano and by the degassing of lavas on the ground. The {sup 226}Ra excess observed in the Masaya lavas can be the result of a second stage of metasomatism which occurred less than 8000 years B.P. during partial fusion. Abstract only. (J.S.).

U-Th-Ra disequilibria at the Masaya (Nicaragua); Desequilibres U-Th-Ra au Masaya (Nicaragua)

Energy Technology Data Exchange (ETDEWEB)

Sigmarsson, O.; Condomines, M. [Centre de Recherches Volcanologiques, CNRS URA-10, 63 - Clermont Ferrand (France)

1996-12-31

{sup 238}U-{sup 230}Th-{sup 226}Ra radioactive disequilibria were measured in several basalt samples of the post-caldera flows of the Masaya volcano (Nicaragua). {sup 230}Th/{sup 232}Th ratios are from the highest known in the world (about 2.53) with {sup 230}Th/{sup 238}U ratios close to 1. These exceptionally high isotopic thorium ratios from the Masaya and other neighboring volcanoes (Conception, Cerro Negro, Momotombo) are followed by very high {sup 10}Be/{sup 9}Be ratios (60 10{sup -11} for the 1722 flow). These geochemical characteristics with {delta}{sup 18}O of typical mantle origin (5.55) suggest an influence of the subducted sediments fluids in the magma source. The age of the metasomatism ranges from 10 to 0.3 Ma. Initial {sup 226}Ra/{sup 230}Th ratios measured in four historical flows vary from 1.3 to 1.4 and are anti-correlated with the Th content. These variations are probably linked to the fractionated crystallisation of plagioclase minerals. The initial {sup 226}Ra/Ba ratio remains constant and suggests the existence of a huge stationary magmatic reservoir. This hypothesis is also confirmed by the disproportion between the SO{sub 2} quantity emitted by the volcano and by the degassing of lavas on the ground. The {sup 226}Ra excess observed in the Masaya lavas can be the result of a second stage of metasomatism which occurred less than 8000 years B.P. during partial fusion. Abstract only. (J.S.).

Direct Measurement of Initial 230TH/ 232TH Ratios in Central Texas Speleothems for More Accurate Age Determination

Science.gov (United States)

Wortham, B. E.; Banner, J. L.; James, E.; Loewy, S. L.

2013-12-01

, 14.6 × 0.83 ppm, 5.8 × 0.56 ppm, and 5.9 × 0.60 ppm, which are higher and more precise than the value commonly assumed for initial 230Th/232Th, 4.4 × 4.4 ppm. Soil sampled above Westcave, a potential source of detrital Th incorporated into speleothems, also has a high calculated 230Th/232Th. We calculate soil 230Th/232Th from measured U and Th concentrations of soil leachates (using DI water and ammonium acetate). Calculated 230Th/232Th for Westcave soils range from 0.39 to 28.4 ppm, which encompasses the range of initial 230Th/232Th values found in the modern calcite. Soil leachates from Natural Bridge Caverns and Inner Space Cavern were analyzed by the same method, yielding calculated 230Th/232Th ranging from 1.5 to 12.6 ppm (Natural Bridge), and from 1.43 to 272 ppm (Inner Space). Soil and calcite data indicate that the commonly assumed initial 230Th/232Th is not always applicable and that initial 230Th/232Th can be estimated more accurately by measuring Th isotope ratios in modern calcite and soils to determine speleothem U-series ages.

Spectral analysis of the IntCal98 calibration curve: a Bayesian view

International Nuclear Information System (INIS)

Palonen, V.; Tikkanen, P.

2004-01-01

Preliminary results from a Bayesian approach to find periodicities in the IntCal98 calibration curve are given. It has been shown in the literature that the discrete Fourier transform (Schuster periodogram) corresponds to the use of an approximate Bayesian model of one harmonic frequency and Gaussian noise. Advantages of the Bayesian approach include the possibility to use models for variable, attenuated and multiple frequencies, the capability to analyze unevenly spaced data and the possibility to assess the significance and uncertainties of spectral estimates. In this work, a new Bayesian model using random walk noise to take care of the trend in the data is developed. Both Bayesian models are described and the first results of the new model are reported and compared with results from straightforward discrete-Fourier-transform and maximum-entropy-method spectral analyses

Marché du carbone et solutions de gestion intégrée des déchets ...

International Development Research Centre (IDRC) Digital Library (Canada)

Marché du carbone et solutions de gestion intégrée des déchets : étude de cas menée en Indonésie. Le Mécanisme de développement propre (MDP) prévu au Protocole de Kyoto signé en 1997 a le double objectif d'aider les pays en développement à connaître un développement durable (tel que défini par chaque pays) ...

Th{sup 232} (n,2n) Th{sup 231} cross section from threshold to 20.4 Mev

Energy Technology Data Exchange (ETDEWEB)

Butler, J P; Santry, D C

1961-07-01

The excitation curve for the reaction Th{sup 232} (n,2n) Th{sup 231} has been measured by the activation method from the threshold energy, 6.34 Mev, to 20.4 Mev, relative to the known cross section for the S{sup 32} (n, p) P{sup 32} reaction. Monoenergetic neutrons were obtained from the D (d,n) He{sup 3} and T (d,n) He{sup 4} reactions employing a Tandem Van de Graaff accelerator. From threshold to 9.0 Mev, the (n,2n) cross section rises rapidly, reaching its maximum value of 1.88 {+-} 0.09 barns in the region of 9.5 to 11.0 Mev. Above 11.5 Mev the (n,2n) cross section decreases due to competition of the (n,3n) and (n,2nf) reactions and at 20.4 Mev it has a value of 0.22{sub 5} {+-} 0.01{sub 5} barns. (author)

Mass distributions in monoenergetic-neutron-induced fission of 232Th

International Nuclear Information System (INIS)

Glendenin, L.E.; Gindler, J.E.; Ahmad, I.; Henderson, D.J.; Meadows, J.W.

1980-01-01

Fission product yields for 38 masses were determined for the fission of 232 Th with essentially monoenergetic neutrons of 2.0, 3.0, 4.0, 5.9, 6.4, 6.9, 7.6, and 8.0 MeV. Fission product activities were measured by Ge(Li) γ-ray spectrometry of irradiated 232 Th foils and by chemical separation of the fission product elements followed by β counting. The mass yield data for 232 Th(n,f ) show a sensitive increase of fission yields in the near-symmetric mass region (valley) with increasing incident neutron energy E/sub n/ and a pronounced dip in yield at the onset of second-chance fission just above the neutron binding energy (at approx. 6 MeV) where the excitation energy is lowered by competition with neutron evaporation prior to fission. The effect of second-chance fission is also seen in the yields of asymmetric peak products. A distinct third peak is observed at symmetry in the valley of the mass distribution, and enhanced yields are observed in the asymmetric peaks at masses associated with even Z (proton pairing effect). The fission yeilds of 232 Th(n,f ) are compared with those of 238 U(n,f ) and 232 Th

Polletten har inte trillat ner, ännu? Bankernas hållbarhetsredovisning håller inte måttet!

OpenAIRE

Lindblom, Helena; Lundgren, Maria

2008-01-01

The voluntary none-financial sustainability report has become a trend within accounting. The environmental issues used to be driven by activists only, but lately it has moved in to the general agenda in many companies. Investors are starting to put more attention to the sustainability reporting as it is considered to add value to the company. There are several standard guidelines to be used when producing a sustainability report, one example is the GRI´s Guidelines that takes the following th...

PREFACE: 12th Russia/CIS/Baltic/Japan Symposium on Ferroelectricity and 9th International Conference on Functional Materials and Nanotechnologies (RCBJSF-2014-FM&NT)

Science.gov (United States)

Sternberg, Andris; Grinberga, Liga; Sarakovskis, Anatolijs; Rutkis, Martins

2015-03-01

The joint International Symposium RCBJSF-2014-FM&NT successfully has united two international events - 12th Russia/CIS/Baltic/Japan Symposium on Ferroelectricity (RCBJSF-12) and 9th International Conference Functional Materials and Nanotechnologies (FM&NT-2014). The RCBJSF symposium is a continuation of series of meetings on ferroelectricity, the first of which took place in Novosibirsk (USSR) in 1976. FM&NT conferences started in 2006 and have been organized by Institute of Solid State Physics, University of Latvia in Riga. In 2012 the International program committee decided to transform this conference into a traveling Baltic State conference and the FM&NT-2013 was organized by the Institute of Physics, University of Tartu, Estonia. In 2014 the joint international symposium RCBJSF-2014-FM&NT was organized by the Institute of Solid State Physics, University of Latvia and was part of Riga - 2014, the European Capital of Culture event. The purpose of the joint Symposium was to bring together scientists, students and high-level experts in solid state physics, materials science, engineering and related disciplines. The number of the registered participants from 26 countries was over 350. During the Symposium 128 high quality scientific talks (5 plenary, 42 invited, 81 oral) and over 215 posters were presented. All presentations were divided into 4 parallel sessions according to 4 main topics of the Symposium: Ferroelectricity, including ferroelectrics and multiferroics, pyroelectrics, piezoelectrics and actuators, integrated ferroelectrics, relaxors, phase transitions and critical phenomena. Multifunctional Materials, including theory, multiscale and multiphenomenal material modeling and simulation, advanced inorganic, organic and hybrid materials. Nanotechnologies, including progressive methods, technologies and design for production, investigation of nano- particles, composites, structures, thin films and coatings. Energy, including perspective materials and

Essentials of Systems Analysis and Design

DEFF Research Database (Denmark)

Kotzab, Herbert

2010-01-01

Book review of: Essentials of Systems Analysis and Design: An international version / Joseph V. Valacich, Joey F. George and Jeffrey A. Hoffer. ( Pearson Education Int., 4th edition, 2009. 464 pages. ISBN: 978-0-13-506984-4; 0-13-506984-X)......Book review of: Essentials of Systems Analysis and Design: An international version / Joseph V. Valacich, Joey F. George and Jeffrey A. Hoffer. ( Pearson Education Int., 4th edition, 2009. 464 pages. ISBN: 978-0-13-506984-4; 0-13-506984-X)...

The effects of social structure and social capital on changes in smoking status from 8th to 9th grade: results of the Child and Adolescent Behaviors in Long-term Evolution (CABLE) study.

Science.gov (United States)

Chen, Chun-Yuan; Wu, Chi-Chen; Chang, Hsing-Yi; Yen, Lee-Lan

2014-05-01

Social structure and social capital are important variables for public health strategies seeking to prevent smoking among adolescents. The purpose of this study was to examine the relationships between social structure, social capital and changes in smoking status from the 8th to 9th grade in Taiwan. Data were obtained from the Child and Adolescent Behaviors in Long-term Evolution (CABLE) project. The study analyzed a final sample of 1937 students (50.7% female). Each layer of social structure was associated with a particular form of social capital. Students whose parents were married and living together had higher family social capital. After controlling for background variables, the social structure variable of friends who smoke was significantly associated with changes in smoking status. Students reporting more school attachment were less likely to start smoking. Students with higher parental supervision was associated with less chance of being a consistent smoker, whereas participation of social organization outside of school was associated with continued smoking. Attending school club was associated with higher probability of smoking cessation. Smoking prevention and intervention strategies aimed at junior high school students should be tailored to the particular form of social capital important for each type of smoking status. Copyright © 2013 Elsevier Inc. All rights reserved.

Intérprete, tu serás Interpreter, you will be

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Márcia Atálla Pietroluongo

2011-12-01

Full Text Available País bilíngue, fundamental no campo dos Estudos da Tradução por suas pesquisas em Terminologia e em Tradução jurídica, o Canadá promoveu e promove inúmeras iniciativas públicas, através de seu Bureau de Traduction, dentre outros organismos, para responder às diversas necessidades nacionais internas. O presente trabalho apresentará um acórdão da Corte Suprema da Nova-Escócia, província do Canadá, conhecido na jurisprudência canadense como o Acórdão Tran (1994, importante documento que estabeleceu pela primeira vez critérios para a fundamentação da "boa interpretação" no meio judicial. Tal decisão da Corte canadense foi incorporada ao Guia para Intérpretes Judiciários, do Ministério da Justiça do Quebec - Direção Geral dos Serviços de Justiça e dos Registros (janeiro de 2001, com edição revista em 2008, traduzido e adaptado por Pierrette Richard, Intérprete Judiciária no Palácio de Justiça de Montreal, do Freelance Court Interpreter's (1995, produzido pelo Serviço de Interpretação Judiciária do Ministério do Procurador Geral de Ontario.A bilingual country, essential in the Translation Studies field for its research on Terminology and Legal Translation, Canada has promoted in the past, and still does, multiple public initiatives, through its Bureau de Traduction, among other bodies, in order to respond to its various national internal needs. This work will present an appellate decision to the Supreme Court of Nova Scotia, a Canadian province, referred in case law as the Tran Decision (1994, an important document which for the first time has set forth the criteria for the grounds of "good interpretation" in the judicial milieu. Such decision from the Canada Court was included in the Guide for Court Interpreters, issued by the Quebec Ministry of Justice - General Direction of Justice and Registration Services (January 2001, revised in 2008, translated and adapted by Pierrette Richard, Court Interpreter in

Th1/Th2 cytokine expression in diabetic retinopathy.

Science.gov (United States)

Cao, Y L; Zhang, F Q; Hao, F Q

2016-07-15

Diabetic retinopathy (DR), an important complication of diabetes mellitus (DM), is not well understood. T helper cell balance (Th1/Th2) is involved in various autoimmune diseases; however, its role in DR is not understood. This study explores changes in Th1 and Th2 cytokine expression during DR. Blood samples were collected from 25 healthy volunteers (normal control group), 35 patients with type 2 DM (T2DM group) without DR, and 30 cases of T2DM patients with DR (DR group). Real-time PCR was used to measure mRNA expression of IL-2 and TNF-α, secreted from Th1 cells, and of IL-4 and IL-10, secreted from Th2 cells. We used ELISA to detect cytokine expression in serum to analyze the correlation between Th1 and Th2 cytokines. IL-2 and TNF-αmRNA and protein expression levels in the T2DM and DR groups were significantly higher than in the normal control group (P 0.05). IL-2 and TNF-αwere negatively correlated with IL-4 and IL-10 in the DR group, respectively. We found that Th1 cytokine secretion was higher and Th2 cytokines secretion was lower during DR, leading to a Th1/ Th2 imbalance, suggesting that Th1/Th2 imbalance is a side effect for DR occurrence and development.

La discrimination : une frontière par rapport à l’intégration

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Rosita Fibbi

2010-12-01

Full Text Available La Suisse s’est dotée d’une politique officielle d’intégration qui s’adresse prioritairement aux nouveaux immigrants. Toutefois les difficultés d’intégration concernent également la jeunesse d’origine immigrée qui réside dans le pays depuis des années. Deux études menées au Forum suisse pour l’étude des migrations et de la population montrent que ces jeunes sont confrontés à la discrimination à l’entrée sur le marché du travail, même lorsqu’ils disposent de qualifications identiques à celles de leurs congénères.Discrimination: a boundary to integrationSwitzerland has developed an official policy of integration with a priority accorded to new immigrants. However, integration difficulties concern also young people of immigrant origins who have lived in the country for a long time. Two studies carried out by the Swiss Forum for the Study of Migrations and the Population show that these young individuals are confronted with discrimination when they seek to enter the work force, even when they dispose of identical qualifications to those of their generation.La discriminación como barrera fronteriza contra la immigraciónSuiza se ha dotado de una política oficial dirigida prioritariamente a los imigrantes recientes. Sin embargo las dificultades de la integración atañen tambien a los jovenes de origen extranjero que residen en el pais desde hace años. Dos estudios realizados por el Foro suizo para el estudio de las migraciones y de la población ponen en evidencia que esos jovenes estan confrontados a la discriminación cuando llegan a la edad de trabajar aunque posean el mismo nivel de cualificación que los autoctonos.

Faut-il intégrer l’argumentation dans l’analyse du discours ? Problématiques et enjeux Should Argumentation be Integrated into Discourse Analysis?

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Ruth Amossy

2012-10-01

Full Text Available Cet article justifie la nécessité pour l’analyse du discours d’intégrer pleinement en son sein l’argumentation comme élément constitutif du discours. Une présentation synthétique de la théorie de l’argumentation dans le discours, à la croisée de la Nouvelle Rhétorique et de l’analyse du discours développée en France, montre cependant en quoi elle diffère de la nouvelle version de la Critical Discourse Analysis qui se nourrit de l’approche normative de la pragma-dialectique. En même temps, elle tente de résoudre les tensions théoriques entre les conceptions de l’argumentation inspirées d’Aristote et de Perelman, et les courants de l’analyse du discours qui reposent sur une vision contemporaine du sujet et des contraintes sociales et institutionnelles qui modèlent le discours. La synthèse théorique est suivie d’une exemplification concrète : une micro-analyse d’un post électronique sur le port de la burqa en France. L’article débouche sur une discussion concernant les modalités selon lesquelles l’analyse qui traite des discours sociaux et des problèmes de société autorise ou exclut l’engagement politique ou éthique des chercheurs.This paper accounts for the necessity of integrating argumentation as a constitutive element of discourse into Discourse Analysis. A synthetic presentation of the theory of argumentation in discourse drawing on New Rhetoric and (French Discourse Analysis shows how it differs from the new version of CDA that is derived from a normative approach to argumentation based on pragma-dialectics. It also endeavors to resolve the theoretical tensions between theories of argumentation borrowed from Aristotle, and trends of Discourse Analysis that rely on contemporary conceptions of the subject and on the social constraints imposed upon discourse. The theoretical synthesis is followed by a concrete exemplification – the micro-analysis of a polemical poston the burqa in

Intérprete de libras em atuação na Educação Infantil e no Ensino Fundamental

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Simone Ferreira Conforto

2017-02-01

Full Text Available Neste texto bastante instigante, a autora nos traz uma grande reflexão do que seria a interpretação/ tradução fazendo uma comparação entre este dois campos. Assim, em relação à interpretação traduzir não é apenas trocar de uma língua para outra, é fundamental definir os sentidos do que se quer e deseja traduzir. Outros autores porém se referem à interpretação e tradução como sendo duas tarefas distintas e na verdade, traduzir é versar de uma língua para outra e interpretar envolveria relações pessoais. Para a autora, na verdade, o que acontece é que o intérprete se envolve em relações sociais e diálogos face a face. Então, o tradutor/intérprete precisa sempre agir com rapidez em suas escolhas e não tem como refletir, sobre o que está interpretando.

Polymorphisms in Th1/Th2 Cytokine Genes, Hormone Replacement Therapy, and Risk of Non-Hodgkin Lymphoma

Energy Technology Data Exchange (ETDEWEB)

Zhu, Gongjian; Pan, Dongsheng [Gansu Provincial Academy of Medical Sciences, Gansu Provincial Tumor Hospital, Lanzhou (China); Yale University School of Public Health, New Haven, CT (United States); Zheng, Tongzhang [Yale University School of Public Health, New Haven, CT (United States); Lan, Qing [Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Rockville, MD (United States); Chen, Xuezhong [Gansu Provincial Academy of Medical Sciences, Gansu Provincial Tumor Hospital, Lanzhou (China); Chen, Yingtai [Yale University School of Public Health, New Haven, CT (United States); Cancer Institute/Hospital, Chinese Academy of Medical Sciences, Beijing, P.R. (China); Kim, Christopher [Yale University School of Public Health, New Haven, CT (United States); Bi, Xiaofeng [Yale University School of Public Health, New Haven, CT (United States); Cancer Institute/Hospital, Chinese Academy of Medical Sciences, Beijing, P.R. (China); Holford, Theodore [Yale University School of Public Health, New Haven, CT (United States); Boyle, Peter [International Prevention Research Institute, Lyon (France); Leaderer, Brian [Yale University School of Public Health, New Haven, CT (United States); Chanock, Stephen J. [Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Rockville, MD (United States); Core Genotyping Facility, Department of Health and Human Services, Advanced Technology Center, National Cancer Institute, National Institutes of Health, Gaithersburg, MD (United States); Rothman, Nathaniel [Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Rockville, MD (United States); Zhang, Yawei, E-mail: yawei.zhang@yale.edu [Yale University School of Public Health, New Haven, CT (United States)

2011-07-28

We conducted a population-based case–control study in Connecticut women to test the hypothesis that genetic variations in Th1 and Th2 cytokine genes modify the relationship between hormone replacement therapy (HRT) and risk of non-Hodgkin lymphoma (NHL). Compared to women without a history of HRT use, women with a history of HRT use had a significantly decreased risk of NHL if they carried IFNGR2 (rs1059293) CT/TT genotypes (OR = 0.5, 95%CI: 0.3–0.9), IL13 (rs20541) GG genotype (OR = 0.6, 95%CI: 0.4–0.9), and IL13 (rs1295686) CC genotype (OR = 0.6, 95%CI: 0.4–0.8), but not among women who carried IFNGR2 CC, IL13 AG/AA, and IL13CT/TT genotypes. A similar pattern was also observed for B-cell lymphoma but not for T-cell lymphoma. A statistically significant interaction was observed for IFNGR2 (rs1059293 P{sub for} {sub interaction} = 0.024), IL13(rs20541 P{sub for} {sub interaction} = 0.005), IL13 (rs1295686 P{sub for} {sub interaction} = 0.008), and IL15RA (rs2296135 P{sub for} {sub interaction} = 0.049) for NHL overall; IL13 (rs20541 P{sub for} {sub interaction} = 0.0009), IL13(rs1295686 P{sub for} {sub interaction} = 0.0002), and IL15RA (rs2296135 P{sub for} {sub interaction} = 0.041) for B-cell lymphoma. The results suggest that common genetic variation in Th1/Th pathway genes may modify the association between HRT and NHL risk.

Synthesis and characterization of Cu3TaIn3Se7 and CuTa2InTe4

International Nuclear Information System (INIS)

Calderon, E.; Munoz-Pinto, M.; Duran-Pina, S.; Quintero, M.; Quintero, E.; Morocoima, M.; Delgado, G.E.; Romero, H.; Briceno, J.M.; Fernandez, J.; Grima-Gallardo, P.

2008-01-01

Polycrystalline samples of Cu 3 TaIn 3 Se 7 and CuTa 2 InTe 4 were synthesized by the usual melt and anneal technique. X-ray powder diffraction showed a single phase behavior for both samples with tetragonal symmetry and unit cell parameter values a=5.794±0.002 A, c=11.66±0.01 A, c/a=2.01, V=391±1 A 3 and a=6.193±0.001 A, c=12.400 ±0.002A, c/a=2.00, V=475±1 A 3 , respectively. Differential thermal analysis (DTA) measurements suggested a complicated behavior near the melting point with several thermal transitions observed in the heating and cooling runs. From the shape of the DTA peaks it was deduced that the melting is incongruent for both materials. Magnetic susceptibility measurements (zero-field cooling and field cooling) indicated an antiferromagnetic character with transition temperatures of T=70 K (Cu 3 TaIn 3 Se 7 ) and 42 K (CuTa 2 InTe 4 ). A spin-glass transition was observed in Cu 3 TaIn 3 Se 7 with T f ∼50 K. (copyright 2008 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

Host Factors Influencing the Retrohoming Pathway of Group II Intron RmInt1, Which Has an Intron-Encoded Protein Naturally Devoid of Endonuclease Activity.

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Rafael Nisa-Martínez

Full Text Available Bacterial group II introns are self-splicing catalytic RNAs and mobile retroelements that have an open reading frame encoding an intron-encoded protein (IEP with reverse transcriptase (RT and RNA splicing or maturase activity. Some IEPs carry a DNA endonuclease (En domain, which is required to cleave the bottom strand downstream from the intron-insertion site for target DNA-primed reverse transcription (TPRT of the inserted intron RNA. Host factors complete the insertion of the intron. By contrast, the major retrohoming pathway of introns with IEPs naturally lacking endonuclease activity, like the Sinorhizobium meliloti intron RmInt1, is thought to involve insertion of the intron RNA into the template for lagging strand DNA synthesis ahead of the replication fork, with possible use of the nascent strand to prime reverse transcription of the intron RNA. The host factors influencing the retrohoming pathway of such introns have not yet been described. Here, we identify key candidates likely to be involved in early and late steps of RmInt1 retrohoming. Some of these host factors are common to En+ group II intron retrohoming, but some have different functions. Our results also suggest that the retrohoming process of RmInt1 may be less dependent on the intracellular free Mg2+ concentration than those of other group II introns.

Los intérpretes generales de Yucatán: hombres entre dos mundos

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Mark Lentz

2009-01-01

Full Text Available Este artículo se centra en un tipo importante de intermediarios en el Yucatán colonial, los intérpretes generales del Juzgado Privado de Indios de Yucatán. Desde la época de Gaspar Antonio Chi en 1580 hasta la desaparición de esta corte en la década de 1820, estos hombres mediaron directamente en disputas de propiedades, quejas contra las autoridades, y tradujeron decretos inicialmente publicados en español para la mayoría maya hablante de la provincia. Sus actividades demuestran que Yucatán poseyó un alto número de individuos que dominaron tanto el maya como el español hasta finales del periodo colonial. Además, la cantidad de individuos calificados sirviendo extra oficial mente como intérpretes durante finales del siglo dieciocho, y el sorprendente número de no-mayas que necesitaron sus servicios, muestran también que el periodo colonial fue una época en la que el maya se extendió como lenguaje predominante en Yucatán, en lugar de una época de declive para ese idioma.This paper focuses one type of important intermediaries of colonial Yucatan, the general interpreters of Yucatan's Juzgado Privado de Indios. From the time of Gaspar Antonio Chi in 1580 until the demise of this court in the 1820s, these men mediated directly in land disputes, complaints against priests and other officials, and translated decrees initially published in Spanish for the province's Maya-speaking majority. The activities of the interpreters demonstrate that Yucatan had a high number of individuals literate and fluent in both Maya and Spanish until the close of the colonial period. Furthermore, the quantity of qualified individuals serving unofficially as interpreters during the late eighteenth century and the surprising number of non-Mayas in need of their services also shows that the colonial period was a time in which Maya spread as the predominant language of Yucatan rather than a time of decline for the region's native language.

Ex-Th17 (Nonclassical Th1) Cells Are Functionally Distinct from Classical Th1 and Th17 Cells and Are Not Constrained by Regulatory T Cells.

Science.gov (United States)

Basdeo, Sharee A; Cluxton, Deborah; Sulaimani, Jamal; Moran, Barry; Canavan, Mary; Orr, Carl; Veale, Douglas J; Fearon, Ursula; Fletcher, Jean M

2017-03-15

Th17 cells are an important therapeutic target in autoimmunity. However, it is known that Th17 cells exhibit considerable plasticity, particularly at sites of autoimmune inflammation. Th17 cells can switch to become ex-Th17 cells that no longer produce IL-17 but produce IFN-γ. These ex-Th17 cells are also called nonclassical Th1 cells because of their ability to produce IFN-γ, similar to Th1 cells; however, it is unclear whether they resemble Th1 or Th17 cells in terms of their function and regulation, and whether they have a pathogenic role in autoimmunity. We compared the phenotypic and functional features of human Th17, Th1, and ex-Th17 cell populations. Our data showed that despite their loss of IL-17 expression, ex-Th17 cells were more polyfunctional in terms of cytokine production than either Th1 or bona fide Th17 cells, and produced increased amounts of proinflammatory cytokines. The proliferative brake on Th17 cells appeared to be lifted because ex-Th17 cells proliferated more than Th17 cells after stimulation. In contrast with Th1 and Th17 cells, ex-Th17 cells were highly resistant to suppression of proliferation and cytokines by regulatory T cells. Finally, we showed that ex-Th17 cells accumulated in the joints of rheumatoid arthritis patients. Taken together, these data indicate that human ex-Th17 cells are functionally distinct from Th1 and Th17 cells, and suggest that they may play a pathogenic role at sites of autoimmunity, such as the rheumatoid arthritis joint where they accumulate. These findings have implications for therapeutic strategies that target IL-17, because these may not inhibit pathogenic ex-Th17 cells. Copyright © 2017 by The American Association of Immunologists, Inc.

The Mincle-activating adjuvant TDB induces MyD88-dependent Th1 and Th17 responses through IL-1R signaling.

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Christiane Desel

Full Text Available Successful vaccination against intracellular pathogens requires the generation of cellular immune responses. Trehalose-6,6-dibehenate (TDB, the synthetic analog of the mycobacterial cord factor trehalose-6,6-dimycolate (TDM, is a potent adjuvant inducing strong Th1 and Th17 immune responses. We previously identified the C-type lectin Mincle as receptor for these glycolipids that triggers the FcRγ-Syk-Card9 pathway for APC activation and adjuvanticity. Interestingly, in vivo data revealed that the adjuvant effect was not solely Mincle-dependent but also required MyD88. Therefore, we dissected which MyD88-dependent pathways are essential for successful immunization with a tuberculosis subunit vaccine. We show here that antigen-specific Th1/Th17 immune responses required IL-1 receptor-mediated signals independent of IL-18 and IL-33-signaling. ASC-deficient mice had impaired IL-17 but intact IFNγ responses, indicating partial independence of TDB adjuvanticity from inflammasome activation. Our data suggest that the glycolipid adjuvant TDB triggers Mincle-dependent IL-1 production to induce MyD88-dependent Th1/Th17 responses in vivo.

Intelligent "Peptide-Gathering Mechanical Arm" Tames Wild "Trojan-Horse" Peptides for the Controlled Delivery of Cancer Nanotherapeutics.

Science.gov (United States)

Shi, Nian-Qiu; Li, Yan; Zhang, Yong; Shen, Nan; Qi, Ling; Wang, Shu-Ran; Qi, Xian-Rong

2017-12-06

Cell-penetrating peptides (CPPs), also called "Trojan-Horse" peptides, have been used for facilitating intracellular delivery of numerous diverse cargoes and even nanocarriers. However, the lack of targeting specificity ("wildness" or nonselectivity) of CPP-nanocarriers remains an intractable challenge for many in vivo applications. In this work, we used an intelligent "peptide-gathering mechanical arm" (Int PMA) to curb CPPs' wildness and enhance the selectivity of R 9 -liposome-based cargo delivery for tumor targeting. The peptide NGR, serving as a cell-targeting peptide for anchoring, and peptide PLGLAG, serving as a substrate peptide for deanchoring, were embedded in the Int PMA motif. The Int PMA construct was designed to be sensitive to tumor microenvironmental stimuli, including aminopeptidase N (CD13) and matrix metalloproteinases (MMP-2/9). Moreover, Int PMA could be specifically recognized by tumor tissues via CD13-mediated anchoring and released for cell entry by MMP-2/9-mediated deanchoring. To test the Int PMA design, a series of experiments were conducted in vitro and in vivo. Functional conjugates Int PMA-R 9 -poly(ethylene glycol) (PEG) 2000 -distearoylphosphatidyl-ethanolamine (DSPE) and R 9 -PEG 2000 -DSPE were synthesized by Michael addition reaction and were characterized by thin-layer chromatography and matrix-assisted laser desorption ionization-time-of-flight mass spectrometry. The Int PMA-R 9 -modified doxorubicin-loaded liposomes (Int PMA-R 9 -Lip-DOX) exhibited a proper particle diameter (approximately 155 nm) with in vitro sustained release characteristics. Cleavage assay showed that Int PMA-R 9 peptide molecules could be cleaved by MMP-2/9 for completion of deanchoring. Flow cytometry and confocal microscopy studies indicated that Int PMA-R 9 -Lip-DOX can respond to both endogenous and exogenous stimuli in the presence/absence of excess MMP-2/9 and MMP-2/9 inhibitor (GM6001) and effectively function under competitive receptor

Aquaculture intérieure et adaptation aux changements climatiques ...

International Development Research Centre (IDRC) Digital Library (Canada)

Institution Country. Thailand. Institution Website. http://www.chiangmai.ac.th ... New funding opportunity for gender equality and climate change ... fostering effective, long-term climate action to reduce social inequality, promote greater gender ...

High-temperature vaporization of thorium-uranium mixed monocarbide (Th1-y, Uy)C

International Nuclear Information System (INIS)

Koyama, Tadafumi; Yamawaki, Michio

1989-01-01

Vaporization thermodynamics of thorium-uranium mixed monocarbide phase (Th 1-y , U y )C was studied by mass spectrometric Knudsen effusion method for the compositions of (Th 0.9 , U 0.1 )C 0.855 , (Th 0.8 , U 0.2 )C 0.973 and (Th 0.6 , U 0.4 )C 0.973 . The partial vapor pressures of Th(g) and U(g) and activities of Th and U of these mixed monocarbides were determined at temperatures ranging from about 2000 to 2200 K. Further, the partial pressures of Th(g) and U(g) and activities of Th and U of the stoichiometric mixed monocarbides (Th 1-y , U y )C 1.00 were evaluated by compensating for the effect of carbon content. The Gibbs energies of formation of stoichiometric (Th 1-y , U y )C 1.00 were also evaluated. (orig.)

Sexual distinction between 5th instar nymphs of six species of Triatominae (Hemiptera, Reduviidae

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João Aristeu da Rosa

1992-06-01

Full Text Available The aim of this paper is to present the analysis of sexual morphological differences observed in 5th instar nymphs of the following species: Panstrongylus megistus; Rhodnius neglectus; Triatoma brasiliensis; T. infestans; T. matogrosensis and T. tibiamaculata. Male and female nymphs were examined and photographed with a Scanning Electron Microscope. The 9th segment dimensions of dorsal and ventral faces were determined through a Profile Projector. Results and statistical analysis showed significant differences: the 9th sternite is significantly broader in male than female nymphs, while in five species; tergites in female nymphs are broad and in male are narrow.

[Changing prevalence of Helicobacter pylori infection in the 9th district of Budapest. A retrospective endoscopic study, 1997-2012].

Science.gov (United States)

Buzás, György Miklós; Lotz, Gábor; Schneider, Ferenc; Józan, Jolán

2013-06-09

The prevalence of Helicobacter pylori infection in developed countries is decreasing. The time-frame of this process is largely unknown. The aim of the authors was to evaluate the changes in the prevalence of Helicobacter pylori infection in their endoscopic centre. This retrospective study included 4647 patients examined between 1997 and 2012. Helicobacter pylori was determined from antral and corpus biopsies by the modified Giemsa stain and rapid urease test. The prevalence of the infection was calculated yearly for the period studied, for age decades from 18 to 85 years, birth cohorts of 10 years from 1920 to 1994 and according to diagnosis. The overall prevalence of Helicobacter pylori infection was 54.7%, which decreased from 71.3% in 1997 to 32.76% in 2011. Functional dyspepsia was found in 37.9%, duodenal ulcer in 25.3%, gastric ulcer in 3.8% and reflux disease in 24.2% of the patients. The mean prevalence of infection was 62.5% in birth cohorts of 10 years between 1920 and 1959, 57.4% in those between 1960 and 1969, and decreased to 39.0% and 26.7% in birth cohorts between 1970 and 1979) and between 1980 and 1989, respectively. According to age cohorts, the prevalence was 21.8% 34.9%, 46.5%, 63.7%, 63.2% and 59.2% in patients aged 18-19 years, 20-29 years, 30-39 years, 40-49 years, 50-59 years and 60-69 years, respectively. The proportion of H. pylori positive duodenal ulcers decreased from 95.9% in 1998 to 59.1% in 2011 (p = 0.001). The prevalence of Helicobacter pylori infection in the 9th district of Budapest is decreasing, especially in cohorts born in the late 1960s and 1970s, nearly 1.5 decades before the discovery of the bacterium.

Properties of 15/2- states in 215Ra and 217Th; evaluation of the 15/2- to 9/2+ E3 strength in N=127 isotones

International Nuclear Information System (INIS)

Dracoulis, G.D.; Riess, R.; Stuchbery, A.E.; Bark, R.A.; Gupta, S.L.; Baxter, A.M.; Kruse, M.

1988-01-01

The lifetime of the yrast 15/2 - state in 215 Ra was measured using pulsed beams and γ-ray and electron techniques. Transition multipolarities were established from measured conversion coefficients. The B(E3) of the 15/2 - → 9/2 + transition is found to be considerably larger than previously reported. A candidate for the corresponding transition in 217 Th was also observed. The E3 strength of the 15/2 - → 9/2 + transition in the N=127 isotones is evaluated in the light of these and other recent results. Interpretation in the framework of particle-octupole vibration coupling requires a systematic lowering of the core 3 - vibration as proton pairs are added to 208 Pb

Is the current CCU Draft 2016b of the 9th SI Brochure scientifically and formally satisfactory? And an example of simpler SI definition

OpenAIRE

Pavese, Franco

2015-01-01

This v.4 includes a critical review adjourned to the CCU Draft 2016b of November 2016 of the 9th SI Brochure in the light of four basic principles that a modern system of units should follow, and a proposal for the text of the CGPM Resolution on the revised SI, intended to resolve the problems found. The contents of the previous versions were: (v.1) discussion of the role of constants (called fundamental until 2015) in the proposed New SI formulation of the definition of the International Sys...

Concentration of 232Th, 230Th and 228Th in various tissues of Japanese subjects

International Nuclear Information System (INIS)

Takizawa, Y.; Qingmei, H.; Hisamatsu, S.; Abe, T.

1997-01-01

The concentration of 232 Th, 230 Th and 228 Th in various human tissues of Japanese subjects obtained at autopsies are reported. The tissue samples were weighed, spiked with 234 Th tracer and ashed by acid. The solution was dried on a hot-plate. Separation of thorium radionuclides was accomplished through cation-exchange resin chromatography and electrodeposition. The concentrations of thorium isotopes were measured by α-spectrometry. Thorium-232 and 230 Th concentrations were found to be highest in lung, followed by bone. The maximum concentration of 228 Th was in bone. The lowest concentrations of thorium isotopes were in muscle. (author)

Towards the year 2000: Critical issues in the global environment. A summary of the 9th World Clean Air Congress of the International Union of Air Pollution Prevention Associations

International Nuclear Information System (INIS)

Rector, A.B.

1992-01-01

The global impact of environmental issues, such as sustainable development, technology transfer North to South and the link between economics and environmental protection, was a central theme at the 9th World Clean Air Congress. The Congress supported increased cooperation among individuals, organizations, governments and companies by providing a forum to share environmental concerns and problem-solving approaches

75 FR 35649 - Safety Zone; Northern California Annual Fireworks Events, July 4th Fireworks Display

Science.gov (United States)

2010-06-23

... Zone; Northern California Annual Fireworks Events, July 4th Fireworks Display AGENCY: Coast Guard, DHS... July Fireworks Display safety zone, from 9 a.m. through 10 p.m. on July 4, 2010 in position 39[deg]10... safety zone for the annual Tahoe City 4th of July Fireworks in 33 CFR 165.1191 on July 4, 2010, from 9 a...

Radioimmunoassays of tetrahydroaldosterone (TH-Aldo) in human urine

International Nuclear Information System (INIS)

Kohl, K.-H.; Vecsei, P.; Abdelhamid, S.

1978-01-01

Specific antisera against tetrahydroaldosterone (TH-Aldo) were raised in two white New Zealand rabbits. 3α,5β-TH-aldo-20-oxime-bovine-serum albumin commplex was used as antigen. The resulting titers were 1:18 000 and 1:16 000. Except tetrahydrocortisol (THF) (0.23%) and tetrahydro-18-hydroxy-11-dehydrocorticosterone (18-OH-THA) (3.2%), all steroids and steroid metabolites gave negligible cross-reactions. Immunograms of the paper chromatograms made from the n-butanol-extract of the urines, as well as after β-glucuronidase treatment and dichlormethane extraction, were studied to further define the specificity of the antiserum. Antibody H 1 (used in this study) reacted with aldosterone-18-gluc., a TH-aldosterone-glucuronide (probably the 21-glucuronide) and an unidentified less polar material. Two methods were developed: a) TH-Aldo-glucuronide(s) estimation after ethylacetate pre-extraction as a rapid screening test of endogenous aldosterone production. b) estimation of TH-aldosterone using one chromatographic system. The results of method a) showed a significant correlation with the values obtained by technique b). Normal values (method b) were 25.88 plus minus 16.50 μg/24 h (range 9.5 - 64.8 μg/24 h). A significant correlation was also shown between the TH-aldo (technique b) and 18-gluc. values. (author)

Th1 and Th2 immune responses related to pelvic endometriosis Resposta imunológica Th1 e Th2 relacionada à endometriose pélvica

Directory of Open Access Journals (Sweden)

Sergio Podgaec

2010-01-01

Full Text Available OBJECTIVE: This study analyzed the relationship between clinical characteristics of endometriosis and Th1/Th2 immune response patterns. METHODS: A prospective study was performed with 65 patients with endometriosis (Group A and 33 without the disease (Group B. Measurement of IL 2, 4 and 10, TNF-alpha and IFN-gamma was carried out in peripheral blood and peritoneal fluid. RESULTS: Serum TNF-alpha was higher in patients with endometriosis who had deep dyspareunia compared to controls (mean 4.5 pg/ml and 2.3 pg/ml, pOBJETIVO: Este estudo analisa a relação entre as características clínicas da endometriose e os padrões da resposta imune Th1/Th2. MÉTODOS: Estudo prospectivo realizado com 65 pacientes com endometriose (Grupo A e 33 pacientes sem a doença (Grupo B. Foram realizadas avaliação no fluido peritoneal e sangue periférico de IL 2, 4 e 10, TNF-alfa e IFN-gama. A significância foi estabelecida em p < 0,05. RESULTADOS: TNF-alfa encontrava-se elevado em pacientes com endometriose que apresentavam dispareunia de profundidade comparado com controle (média 4,5 pg/ml e 2,3 pg/ml, p< 0,05. Dentre essas pacientes (n=32, 65,5% apresentavam endometriose profunda. Pacientes com endometriose e infertilidade apresentavam concentrações maiores de IL-2 no fluido peritoneal quando comparadas com controle (média 5,9 pg/ml e 0,2 pg/ml, p< 0,05, sendo que neste grupo, 63,5% (n=14 apresentavam endometriose profunda. Foi observada também maior concentração de IL-10 nas pacientes que apresentavam endometriose ovariana quando comparadas às sem esse tipo de endometriose, assim como quando comparadas às pacientes do grupo controle (média 50pg/ml, 18,7pg/ml e 25,7pg/ml, p<0,05. CONCLUSÃO: Estes resultados sugerem que quando dados clínicos específicos associam-se a uma produção elevada de certas citocinas, ocorre um padrão de resposta Th1 que pode estar associado à endometriose profunda.

10th International Geostatistics Congress

CERN Document Server

Rodrigo-Ilarri, Javier; Rodrigo-Clavero, María; Cassiraga, Eduardo; Vargas-Guzmán, José

2017-01-01

This book contains selected contributions presented at the 10th International Geostatistics Congress held in Valencia from 5 to 9 September, 2016. This is a quadrennial congress that serves as the meeting point for any engineer, professional, practitioner or scientist working in geostatistics. The book contains carefully reviewed papers on geostatistical theory and applications in fields such as mining engineering, petroleum engineering, environmental science, hydrology, ecology, and other fields.

Relationships between Work Values, Socio-Educational and Work Experiences, and Vocational Aspirations of 6th, 9th, 10th, and 12th Graders

Science.gov (United States)

Wijting, Jan P.; And Others

1977-01-01

Using a cross-sectional design and canonical regression analysis, the differential relationships between work values and social, educational, and occupational experiences and aspirations were examined for boys and girls in grades 6, 9, 10, and 12. Support was found for predicted differences in work-values correlates across grades and between…

Dysregulated CD46 shedding interferes with Th1-contraction in systemic lupus erythematosus.

Science.gov (United States)

Ellinghaus, Ursula; Cortini, Andrea; Pinder, Christopher L; Le Friec, Gaelle; Kemper, Claudia; Vyse, Timothy J

2017-07-01

IFN-γ-producing T helper 1 (Th1) cell responses mediate protection against infections but uncontrolled Th1 activity also contributes to a broad range of autoimmune diseases. Autocrine complement activation has recently emerged as key in the induction and contraction of human Th1 immunity: activation of the complement regulator CD46 and the C3aR expressed by CD4 + T cells via autocrine generated ligands C3b and C3a, respectively, are critical to IFN-γ production. Further, CD46-mediated signals also induce co-expression of immunosuppressive IL-10 in Th1 cells and transition into a (self)-regulating and contracting phase. In consequence, C3 or CD46-deficient patients suffer from recurrent infections while dysregulation of CD46 signaling contributes to Th1 hyperactivity in rheumatoid arthritis and multiple sclerosis. Here, we report a defect in CD46-regulated Th1 contraction in patients with systemic lupus erythematosus (SLE). We observed that MMP-9-mediated increased shedding of soluble CD46 by Th1 cells was associated with this defect and that inhibition of MMP-9 activity normalized release of soluble CD46 and restored Th1 contraction in patients' T cells. These data may deliver the first mechanistic explanation for the increased serum CD46 levels observed in SLE patients and indicate that targeting CD46-cleaving proteases could be a novel avenue to modulate Th1 responses. © 2017 The Authors. European Journal of Immunology published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Statement on the 20th anniversary of the Vienna International Centre, Vienna, 9 October 1999

International Nuclear Information System (INIS)

ElBaradei, M.

1999-01-01

In his Statement on the 20th Anniversary of the Vienna International Centre, the Director General of the IAEA presented the work of the Agency and described how it contributes to two main objectives, namely human development and security

Computational mediation as factor of motivation and meaningful learning in education of sciences of 9th grade: astronomy topics

Science.gov (United States)

Da Silva, F. M.; Furtado, W. W.

2012-10-01

The main purpose of this study was to analyze the contribution of using hypertext and pedagogic mediation in search of a Meaningful Learning Process in Sciences. We investigate the usage of hypertext in the teaching and learning methods of Astronomy modules. A survey was conducted with students from the 9th grade of Primary School of a public school in the city of Goiânia, Goiás in Brazil. We have analyzed the possibilities that hypermedia can offer in the teaching and learning process, using as reference David Ausubel's Theory of Meaningful Learning. The study was divided into four phases: application of an initial questionnaire on students, development of didactic material (hypertext), six classes held in a computer lab with the use of hypermedia and a final questionnaire applied in the lab after classes. This research indicated that the use of hypertext linked to pedagogical mediation processes is seen as a motivational tool and has potential to foster to Meaningful Learning.

IL-4 enhances IL-10 production in Th1 cells: implications for Th1 and Th2 regulation.

Science.gov (United States)

Mitchell, Ruth E; Hassan, Masriana; Burton, Bronwen R; Britton, Graham; Hill, Elaine V; Verhagen, Johan; Wraith, David C

2017-09-12

IL-10 is an immunomodulatory cytokine with a critical role in limiting inflammation in immune-mediated pathologies. The mechanisms leading to IL-10 expression by CD4 + T cells are being elucidated, with several cytokines implicated. We explored the effect of IL-4 on the natural phenomenon of IL-10 production by a chronically stimulated antigen-specific population of differentiated Th1 cells. In vitro, IL-4 blockade inhibited while addition of exogenous IL-4 to Th1 cultures enhanced IL-10 production. In the in vivo setting of peptide immunotherapy leading to a chronically stimulated Th1 phenotype, lack of IL-4Rα inhibited the induction of IL-10. Exploring the interplay of Th1 and Th2 cells through co-culture, Th2-derived IL-4 promoted IL-10 expression by Th1 cultures, reducing their pathogenicity in vivo. Co-culture led to upregulated c-Maf expression with no decrease in the proportion of T-bet + cells in these cultures. Addition of IL-4 also reduced the encephalitogenic capacity of Th1 cultures. These data demonstrate that IL-4 contributes to IL-10 production and that Th2 cells modulate Th1 cultures towards a self-regulatory phenotype, contributing to the cross-regulation of Th1 and Th2 cells. These findings are important in the context of Th1 driven diseases since they reveal how the Th1 phenotype and function can be modulated by IL-4.

[Study on the correlation of the effect of entecavir on Th1/Th2 cytokines level in the treatment of chronic hepatitis].

Science.gov (United States)

Li, L; Jing, Y B; Liu, J; Wang, C L; Liu, B

2017-08-20

Objective: To explore the expression level of peripheral blood Th1/Th2 type cytokines of chronic hepatitis b (CHB) patients in the entecavir (ETV) antiviral treatment, analyze the relationship between various cytokines, and the correlation among of cytokines and HBV DNA loads. Methods: Luminex Liquid Chip Technology was applied to detect the peripheral blood Th1/Th2 type cytokines expression level of CHB patients; At the same time, liver function was detected by Fully Automatic Biochemical Analyzer; HBV DNA loads were detected by PCR Method; Hepatitis b virology markers were detected by Chemiluminescence Method. F-test and Pearson correlation analysis were used for statistical analysis. Results: Before ETV antiviral treatment, peripheral blood Th1 cytokines IFN gamma expression level in patients with CHB increased significantly ( P = 0.010) compared with the healthy control group while TNF alpha expression level having no statistically significant difference ( P = 0.095); Th2 type cytokines IL-4, IL-6, IL-10 levels decreased obviously ( P = 0.039, P = 0.014, P = 0.026) compared with those in the control group. After 48 weeks of treatment, Th1 cytokines IFN gamma and TNF alpha expression levels were reduced significantly (19.2±5.03 pg/ml vs 24.69±6.51 pg/ml, and 6.09±4.99 pg/ml vs 9.50±7.34 pg/ml, P Th1/Th2 type cytokines. And there was no correlation between the various cytokines and HBV DNA loads in patients with CHB. Conclusion: ETV can not only inhibit HBV DNA replication, reducing HBV DNA loads, but also contribute to regulate Th1/Th2 type cytokines expression level in patients with CHB, but there was no correlation between the levels of various cytokines, various cytokines and HBV DNA loads.

Comparison of Values in 5th, 6th, 7th and 8th Grade Primary Education Music Class Students'? Workbooks According to Rokeach?s and Akbas's Value Classifications

Science.gov (United States)

Çakirer, H. Serdar

2014-01-01

The aim of the present study is to compare the values in the songs of 5th, 6th, 7th and 8th grade primary education music classes students? workbooks according to the value categorizations proposed by Rockeach and Akbas and which values among the categories mentioned are taught to the students in the 5th, 6th, 7th and 8th grade primary education…

Les migrantes, la sécurité économique et le défi de la réintégration ...

International Development Research Centre (IDRC) Digital Library (Canada)

Ce projet portera sur la réintégration de Philippines revenant au pays après leur passage dans les importants centres d'activités de Hong Kong, Taïwan et Singapour. La recherche sera dirigée par aidha, un organisme à but non lucratif qui offre aux travailleuses migrantes, en particulier aux aides familiales, des formations ...

[Comparison of screw' inserting angle through the 11th and 12th rib anterior approaches for L1 burst fracture].

Science.gov (United States)

Ma, Li-Tai; Liu, Hao; Li, Tao; Song, Yue-Ming; Pei, Fu-Xing; Liu, Li-Min; Gong, Quan; Zeng, Jian-Cheng; Feng, Gan-Jun; Zhou, Zhong-Jie

2012-12-01

To compare screw's inserting angle through the 11th and 12th rib in treating L1 burst fracture, explore effects on inserting screw and postoperative angle. From October 2007 to October 2010, 108 patients with L1 brust fracture treated through anterior approach were analyzed,including 68 males and 40 females, aged from 21 to 64 years (mean 38.22 years). All patients were divided into the 11th (A, 51 cases) and 12th (B, 57 cases) approach. The data of operation time,blood loss, duration of incision pain, JOA score, Oswestry score, VAS score, quality of life (SF-36), recovery of nervous function, coronal Cobb angle, included angle between screw and plate were observed. All patients were followed up for 9 to 37 months, mean 23 months. The operation time, blood loss, duration of incision pain, in group A were lower than group B (P0.05). There were no differences in Cobb angle before operation, but had significance after operation (P=0.000). There were statistically significance between two group in angle between screw and plate (P=0.000, P=0.003). The 11th rib approach for the treatment of L1 burst fracture has less effects on screw, less trauma and less angle between screw and plate.

Down-regulation of the Th1, Th17, and Th22 pathways due to anti-TNF-α treatment in psoriasis.

Science.gov (United States)

Luan, Li; Han, Shixin; Wang, Hua; Liu, Xiaoming

2015-12-01

Psoriasis is a T-cell-mediated chronic inflammatory dermatosis. Th1, Th17 and Th22 cells are suggested to contribute to the pathogenesis of psoriasis. To determine whether treatment with the anti-tumor-necrosis-factor antagonist, adalimumab, induces significant modulation of the Th1, Th17 and Th22 pathways, and correlates cellular activity with clinical response. This study included 21 patients with moderate-to-severe psoriasis who were treated with adalimumab, and 10 healthy control subjects. Blood samples were collected at baseline and at week 12. Flow cytometry was used to analyze the frequency of circulating Th1, Th17 and Th22 cells. Real-time polymerase chain reaction was used to analyze the expression of T-bet (Th1-related), retinoid-acid receptor-related orphan receptor gamma t (RORγt, Th17-related) and aryl hydrocarbon receptor (AHR, Th22-related). An enzyme-linked immunosorbent assay was used to analyze the serum levels of IFN-γ, IL-17, IL-22, IL-6 and tumor necrosis factor-α (TNF-α). At baseline, the frequencies of Th1, Th17 and Th22 cells were higher in psoriasis patients compared to the healthy controls. The expression of transcription factors T-bet, RORγt and AHR, and the serum levels of IFN-γ, IL-17, IL-22, IL-6 and TNF-α were higher in psoriasis patients compared to the healthy controls. After adalimumab therapy, there was a significant decline in the frequencies of Th1, Th17 and Th22 cells, and a concomitant decrease in the levels of their associated transcription factors and cytokines. The results suggest that the anti-tumor-necrosis-factor antagonist, adalimumab, disrupts the Th1, Th17 and Th22 pathways, resulting in clinical improvement of psoriasis. Copyright © 2015 Elsevier B.V. All rights reserved.

Élaboration d'une stratégie de lutte intégrée contre la pollution de l ...

International Development Research Centre (IDRC) Digital Library (Canada)

Élaboration d'une stratégie de lutte intégrée contre la pollution de l'eau à Yorito, au Honduras. Le Honduras connaît des problèmes chroniques de gestion des eaux usées et des déchets solides. Dans le cadre de réformes de décentralisation effectuées récemment, un projet de gestion des déchets axé sur la collectivité ...

Thorium Th

International Nuclear Information System (INIS)

Busev, A.I.; Tiptsova, V.G.; Ivanov, V.M.

1978-01-01

The basic methods for extracting thorium from monazites and determining it photometrically and complexometrically are described. Monazite is decomposed by fusion with sodium peroxide, then thorium and the totality of lanthanides are precipitated in the form of oxalates. After the oxalates have been broken down, thorium is determined photometrically with the aid of arsenazo 1, quercetin of 1-2(-pyridylazo)-resorcin. It takes 25 to 30 minutes to photometrically determine Th in monazites with the aid of arsenazo 2 (error: 3 to 5%). Arsenazo 2 is recommended for analysis of monazites containing 20 to 30% of lanthanides. Arsenazo 3 permits determining Th in zircon and in Nb-containing materials. In this case, the determination is possible in strongly acidic solutions, the ratio of arsenazo 3 to Th being 7.5:1. Arsenazo 3 can also be used in determining trace amounts of Th (1x10 -5 to 1x10 -4 %) in rocks, as well as in extraction-photometric determination of Th traces. The dyed compound of Th with arsenazo 3 is extracted with isoamyl alcohol in the presence of diphenylguanidinium chloride and monochloroacetic acid. The method permits determining Th at 1:5x10 8 (0.002 g/ml) dilution. Also described is the iodate-complexometric method for determining Th

U-Th Burial Dates on Ostrich Eggshell

Science.gov (United States)

Sharp, W. D.; Fylstra, N. D.; Tryon, C. A.; Faith, J. T.; Peppe, D. J.

2015-12-01

Obtaining precise and accurate dates at archaeological sites beyond the range of radiocarbon dating is challenging but essential for understanding human origins. Eggshells of ratites (large flightless birds including ostrich, emu and others) are common in many archaeological sequences in Africa, Australia and elsewhere. Ancient eggshells are geochemically suitable for the U-Th technique (1), which has about ten times the range of radiocarbon dating (>500 rather than 50 ka), making eggshells attractive dating targets. Moreover, C and N isotopic studies of eggshell provide insights into paleovegetation and paleoprecipitation central to assessing past human-environment interactions (2,3). But until now, U-Th dates on ratite eggshell have not accounted for the secondary origin of essentially all of their U. We report a novel approach to U-Th dating of eggshell that explicitly accounts for secondary U uptake that begins with burial. Using ostrich eggshell (OES) from Pleistocene-Holocene east African sites, we have measured U and 232Th concentration profiles across OES by laser ablation ICP-MS. U commonly peaks at 10s to 100s of ppb and varies 10-fold or more across the ~2 mm thickness of OES, with gradients modulated by the layered structure of the eggshell. Common Th is high near the shell surfaces, but low in the middle "pallisade" layer of OES, making it optimal for U-Th dating. We determine U-Th ages along the U concentration gradient by solution ICP-MS analyses of two or more fractions of the pallisade layer. We then estimate OES burial dates using a simple model for diffusive uptake of uranium. Comparing such "U-Th burial dates" with radiocarbon dates for OES calcite from the same shells, we find good agreement in 7 out of 9 cases, consistent with rapid burial and confirming the accuracy of the approach. The remaining 2 eggshells have anomalous patterns of apparent ages that reveal they are unsuitable for U-Th dating, thereby providing reliability criteria innate

Thermal expansion of ThO2-2 wt% UO2 by HT-XRD

International Nuclear Information System (INIS)

Tyagi, A.K.; Mathews, M.D.

2000-01-01

The linear thermal expansion of polycrystalline ThO 2 -2 wt% UO 2 has been investigated from room temperature to 1473 K in flowing helium atmosphere using high temperature X-ray diffractometry. ThO 2 -2 wt% UO 2 shows a marginally higher linear thermal expansion as compared to pure ThO 2 . The average linear and volume thermal expansion coefficients of ThO 2 -2 wt% UO 2 are found to be α-bar a =9.74x10 -6 K -1 and α-bar v =29.52x10 -6 K -1 (298-1473 K). This study will be useful in designing the nuclear reactor fuel assembly based on ThO 2

12th Russia/CIS/Baltic/Japan Symposium on Ferroelectricity and 9th International Conference on Functional Materials and Nanotechnologies (RCBJSF–2014–FM and NT)

International Nuclear Information System (INIS)

Sternberg, Andris; Grinberga, Liga; Sarakovskis, Anatolijs; Rutkis, Martins

2015-01-01

The joint International Symposium RCBJSF–2014–FM and NT successfully has united two international events – 12th Russia/CIS/Baltic/Japan Symposium on Ferroelectricity (RCBJSF-12) and 9th International Conference Functional Materials and Nanotechnologies (FM and NT-2014). The RCBJSF symposium is a continuation of series of meetings on ferroelectricity, the first of which took place in Novosibirsk (USSR) in 1976. FM and NT conferences started in 2006 and have been organized by Institute of Solid State Physics, University of Latvia in Riga. In 2012 the International program committee decided to transform this conference into a traveling Baltic State conference and the FM and NT-2013 was organized by the Institute of Physics, University of Tartu, Estonia. In 2014 the joint international symposium RCBJSF–2014–FM and NT was organized by the Institute of Solid State Physics, University of Latvia and was part of Riga – 2014, the European Capital of Culture event. The purpose of the joint Symposium was to bring together scientists, students and high-level experts in solid state physics, materials science, engineering and related disciplines. The number of the registered participants from 26 countries was over 350. During the Symposium 128 high quality scientific talks (5 plenary, 42 invited, 81 oral) and over 215 posters were presented. All presentations were divided into 4 parallel sessions according to 4 main topics of the Symposium: Ferroelectricity, including ferroelectrics and multiferroics, pyroelectrics, piezoelectrics and actuators, integrated ferroelectrics, relaxors, phase transitions and critical phenomena. Multifunctional Materials, including theory, multiscale and multiphenomenal material modeling and simulation, advanced inorganic, organic and hybrid materials. Nanotechnologies, including progressive methods, technologies and design for production, investigation of nano- particles, composites, structures, thin films and coatings. Energy, including

O intérprete universitário da Língua Brasileira de Sinais na cidade de Curitiba A sign language university level interpreter working in the city of Curitiba

Directory of Open Access Journals (Sweden)

Ana Cristina Guarinello

2008-04-01

Full Text Available No Brasil, o trabalho com intérpretes em Língua Brasileira de Sinais iniciou-se nos anos 80 e pode, dessa forma, ser considerado recente, assim como também é recente a legitimidade da sua importância que ainda está em processo de consolidação. A presente pesquisa tem como principal objetivo discutir e explicitar questões relativas ao trabalho de intérpretes de língua de sinais em uma universidade e dois centros universitários particulares da cidade de Curitiba. Para isto foram aplicados dois questionários para dois grupos distintos, um voltado para os intérpretes que atuam em universidades da cidade de Curitiba, e outro voltado para os surdos universitários que possuem intérpretes em sala de aula. Ambos os questionários continham questões abertas e fechadas. De acordo com as análises dos dados, constatou-se a importância dos intérpretes em sala de aula para o processo de aprendizagem dos estudantes surdos. Contudo, verificou-se também uma série de questões que subjaze a discussão sobre a efetividade no contexto da interpretação, tais como: qualidade na formação dos intérpretes, conhecimento antecipado da disciplina para a tradução, dificuldade na relação Língua Portuguesa/LIBRAS, relação intérprete/professor, dentre outras. A partir dessas considerações, vemos que, no cenário da educação dos surdos brasileiros, essas questões apenas refletem o descaso das autoridades com relação à educação dessa população, assim como evidenciam as dificuldades lingüísticas e sociais relativas à surdez. Esse trabalho apresenta-se, nessa direção, como o início de uma reflexão sobre o contexto do intérprete universitário, porém, muito ainda precisa ser entendido para que mudanças mais efetivas possam ser realizadas.In Brazil, work with Brazilian sign language (Libras interpreters began in the eighties, so this can be said to be a recent proposal, as is recent the consideration of sign language as a

Measurement of the neutron capture cross-section of 232Th using the neutron activation technique

International Nuclear Information System (INIS)

Naik, H.; Singh, Sarbjit; Goswami, A.; Manchanda, V.K.; Prajapati, P.M.; Surayanarayana, S.V.; Nayak, B.K.; Sharma, S.C.; Jagadeesan, K.C.; Thakare, S.V.; Raj, D.; Ganesan, S.; Mulik, V.K.; Sivashankar, B.S.; Mukherjee, S.

2011-01-01

The 232 Th(n, γ) reaction cross-section at average neutron energies of 3.7±0.3 MeV and 9.85±0.38 MeV from the 7 Li(p, n) reaction has been determined for the first time using activation and off-line γ -ray spectrometric technique. The 232 Th(n, 2n) reaction cross-section at the average neutron energy of 9.85±0.38 MeV has been also determined using the same technique. The experimentally determined 232 Th(n, γ) and 232 Th(n, 2n) reaction cross-sections were compared with the evaluated data of ENDF/B-VII, JENDL-4.0 and JEFF-3.1 and were found to be in good agreement. The present data along with literature data in a wide range of neutron energies were interpreted in terms of competition between different reaction channels including fission. The 232 Th(n, γ) and 232 Th(n, 2n) reaction cross-sections were also calculated theoretically using the TALYS 1.2 computer code and were found to be slightly higher than the experimental data. (orig.)

Cross-border recruitment and artificial arrangements : INT-AR Paper 9

NARCIS (Netherlands)

Cremers, Jan

2017-01-01

This paper aims to give an overview of the state of the art with regard to the scientific and empirical knowledge on ‘letterbox companies’. The broad spectrum of practices that can be associated with the notion of letterbox companies has led to fact-finding, evidence based research and other

Th1 and Th2 help for B cells

DEFF Research Database (Denmark)

Poudrier, J; Owens, T

1995-01-01

that IL-5 (125 U/ml) synergizes with Th1 cells to induce B cell responses to IL-2, that are maintained following T-cell removal, e.g. autonomous. Th1 help in the absence of IL-5 resulted in weak or undetectable responses following T cell removal. The mechanism of IL-5 synergy involved persistence of IL-2R...... anti-Ig did not circumvent the need for IL-5 for autonomous IL-2 responses. Consistent with the above, interaction with an IL-5-producing Th2 clone induced strong autonomous B cell responses to IL-2. Qualitative differences of Th2 help over that of Th1 may thus be attributable to their differential...

The 8th-10 th January 2009 snowfalls: a case of Mediterranean warm advection event

Science.gov (United States)

Aguado, F.; Ayensa, E.; Barriga, M.; Del Hoyo, J.; Fernández, A.; Garrido, N.; Martín, A.; Martín, F.; Roa, I. Martínez, A.; Pascual, R.

2009-09-01

From 8 th to 10 th of January 2009, significant snowfalls were reported in many areas of the Iberian Peninsula and the Balearic Islands. This relevant event was very important from the meteorological and social impact point of views. The snow affected many zones, especially the regions of Madrid, Castilla & León and Castilla-La Mancha (Spanish central plateau) with the persistence and thickness of solid precipitation. Up to twenty-five centimetres of snow were reported in some places. On 9th of January the snowfalls caused great social and media impact due to the fact that they took place in the early hours in the Madrid metropolitan areas, affecting both air traffic and land transport. The "Madrid-Barajas" airport was closed and the city was collapsed during several hours. A study of this situation appears in the poster. The snowstorm was characterized by the previous irruption of an European continental polar air mass, that subsequently interacted with a wet and warm air mass of Mediterranean origin, all preceded by low level easterly flows. This type of snowfall is called "warm advection". These winter situations are very efficient from precipitation point of view, generating significant snowfalls and affecting a lot of areas.

In vitro Comparative Evaluation of Tensile Bond Strength of 6(th), 7(th) and 8(th) Generation Dentin Bonding Agents.

Science.gov (United States)

Kamble, Suresh S; Kandasamy, Baburajan; Thillaigovindan, Ranjani; Goyal, Nitin Kumar; Talukdar, Pratim; Seal, Mukut

2015-05-01

Newer dentin bonding agents were developed to improve the quality of composite restoration and to reduce time consumption in its application. The aim of the present study was to evaluate tensile bond strength of 6(th), 7(th) and 8(th) generation bonding agents by in vitro method. Selected 60 permanent teeth were assigned into 20 in each group (Group I: 6(th) generation bonding agent-Adper SE plus 3M ESPE, Group II: 7(th) generation bonding agent-G-Bond GC Corp Japan and Group III: 8(th) generation dentin adhesives-FuturaBond, DC, Voco, Germany). With high-speed diamond disc, coronal dentin was exposed, and selected dentin bonding agents were applied, followed by composite restoration. All samples were saved in saline for 24 h and tensile bond strength testing was done using a universal testing machine. The obtained data were tabulated and statistically analyzed using ANOVA test. The tensile bond strength readings for 6(th) generation bonding agent was 32.2465, for 7(th) generation was 31.6734, and for 8(th)-generation dentine bonding agent was 34.74431. The highest tensile bond strength was seen in 8(th) generation bonding agent compared to 6(th) and 7(th) generation bonding agents. From the present study it can be conclude that 8(th) generation dentine adhesive (Futura DC, Voco, Germany) resulted in highest tensile bond strength compared to 6(th) (Adper SE plus, 3M ESPE) and 7(th) generation (G-Bond) dentin bonding agents.

Classification of nasolabial folds in Asians and the corresponding surgical approaches: By Shanghai 9th People's Hospital.

Science.gov (United States)

Zhang, Lu; Tang, Meng-Yao; Jin, Rong; Zhang, Ying; Shi, Yao-Ming; Sun, Bao-Shan; Zhang, Yu-Guang

2015-07-01

One of the earliest signs of aging appears in the nasolabial fold, which is a special anatomical region that requires many factors for comprehensive assessment. Hence, it is inadequate to rely on a single index to facilitate the classification of nasolabial folds. Through clinical observation, we have observed that traditional filling treatments provide little improvement for some patients, which prompted us to seek a more specific and scientific classification standard and assessment system. A total of 900 patients who sought facial rejuvenation treatment in Shanghai 9th People's Hospital were invited in this study. We observed the different nasolabial fold traits for different age groups and in different states, and the results were compared with the Wrinkle Severity Rating Scale (WSRS). We summarized the data, presented a classification scheme, and proposed a selection of treatment options. Consideration of the anatomical and histological features of nasolabial folds allowed us to divide nasolabial folds into five types, namely the skin type, fat pad type, muscular type, bone retrusion type, and hybrid type. Because different types of nasolabial folds require different treatments, it is crucial to accurately assess and correctly classify the conditions. Copyright © 2015 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

The Relationships between Human Fatigue and Public Health: A Brief Commentary on Selected Papers from the 9th International Conference on Managing Fatigue in Transportation, Resources and Health

OpenAIRE

Charli Sargent; Paul Roberts; Drew Dawson; Sally Ferguson; Lynn Meuleners; Libby Brook; Gregory D. Roach

2016-01-01

The 9th International Conference on Managing Fatigue in Transportation, Resources and Health was held in Fremantle, Western Australia in March 2015. The purpose of the conferences in this series is to provide a forum for industry representatives, regulators, and scientists to discuss recent advances in the field of fatigue research. We have produced a Special Issue of the International Journal of Environmental Research and Public Health based on papers from the conference that were focused on...

Transport of Th(IV) and U(VI) through barium silico-phosphate composite membrane using electric field

International Nuclear Information System (INIS)

Zaki, E.E.

2002-01-01

The present paper describes the preparation of a novel barium silico-phosphate filter paper supported membrane. It is based on precipitation reaction of barium silico-phosphate on the outer surface and in the interstices of a filter paper by means of electrodialysis. The main physical and electrical properties of the membrane are given and its electrodialysis behaviour is assessed for Th(IV) and U(VI). The transport of Th(IV) in presence of U(VI) was studied. The cationic fluxes of Th(IV) and U(VI) were found to be 1.2 x 10 -8 and 6.5 x 10 -9 g eq cm -2 s -1 , respectively. Transport of Th(IV) and U(VI) in presence of EDTA was investigated. The cationic flux of U(VI) is found to be 9.8 x 10 -9 g eq cm -2 s -1 at a current density of 25 mA/cm 2 . A comparative study on the electro osmotic effect was carried out using the developed membrane and commercially available Nafion membranes. In this context, different parameters like current density, electrolyte concentration, etc. were investigated. The electro-osmotic permeability coefficient, D e , of Th(IV) through barium silico-phosphate and Nafion membranes were 6.9 x 10 -2 and 1.0 x 10 -2 cm 3 /As, respectively. It can be concluded that inorganic membranes have very marked electro-osmotic properties unlike their organic counterparts. (orig.)

Baltic minds debate the May-9th-in-Moscow dilemma

Index Scriptorium Estoniae

2005-01-01

Katkendeid osalejate sõnavõttudest videokonverentsil, kus arutati Balti riikide presidentide osavõttu Teise maailmasõja aastapäeva pidustustest Moskvas 9. mail. Osalejate seas oli ka Riigikogu liige Enn Eesmaa

The role of Th1 and Th17 cells in glomerulonephritis.

Science.gov (United States)

Azadegan-Dehkordi, Fatemeh; Bagheri, Nader; Shirzad, Hedayatollah; Rafieian-Kopaei, Mahmoud

2015-04-01

T helper (Th) cells as an important part of the immune is responsible for elimination of invading pathogens. But, if Th cell responses are not regulated effectively, the autoimmune diseases might develop. The Th17 subset usually produces interleukin-17A which in experimental models of organ-specific autoimmune inflammation is very important. Directory of open access journals (DOAJ), Google Scholar, Embase, Scopus, PubMed and Web of Science have been searched. Fifty-six articles were found and searched. In the present review article, we tried to summarize the recently published data about characteristics and role of Th1 and Th17 cells and discuss in detail, the potential role of these T helpers immune responses in renal inflammation and renal injury, focusing on glomerulonephritis. Published papers in animal and human studies indicated that autoimmune diseases such as rheumatoid arthritis and multiple sclerosis, classically believed to be Th1-mediated, are mainly derived from a Th17 immune response. Identification of the Th17 subgroup has explained seemingly paradoxical observations and improved our understanding of immune-mediated inflammatory responses. Secretion of IL-17A, as well as IL-17F, IL-21, IL-22, suggests that Th17 subset may play a crucial role as a pleiotropic pro-inflammatory Th subset. There is experimental evidence to support the notion that Th1 and Th17 cells contribute to kidney injury in renal inflammatory diseases like glomerulonephritis.

Proceedings from the 9th Annual Meeting of International Society for Medical Publication Professionals Roundtable Session: key insights.

Science.gov (United States)

Simcoe, Donna; Juneja, Renu; Scott, Gayle Nicholas; Sridharan, Kanaka; Williams-Hughes, Celeste

2014-03-01

During the 9th Annual Meeting of the International Society for Medical Publication Professionals (ISMPP, April 29-May 1, 2013 in Baltimore, MD), ∼650 participants attended two of 13 available roundtable sessions. Participants included medical publication professionals from industry, communication agencies, and journals. DISCUSSION TOPICS: Roundtable participants discussed how to best interpret and implement various guidances, such as Good Publication Practices 2 (GPP2), the International Committee of Medical Journal Editors (ICMJE) guidelines, and the Physician Payment Sunshine Act. The impact of and compliance with Corporate Integrity agreements (CIAs) on medical publication planning practices was debated. Roundtable participants also discussed ways of advancing both advocacy for the medical publication professional field and internal and external collaborations. The development of review manuscripts, publications from regions newly emerging in publication planning, medical devices publications, and real-world experience publications were discussed. Participants also considered the benefits and uncertainties of new technologies in medical publications such as multimedia and social media. This is the first ever article to be published following the well-attended ISMPP roundtable sessions. The objective of this manuscript is to summarize key learnings that will aid continued discussions about challenges and opportunities facing medical publication professionals.

The relationship among critical thinking skill measured by science virtual test, gender, andmotivation in 9th grade students

Science.gov (United States)

Fernandi, R. A. U. I.; Firman, H.; Rusyati, L.

2018-05-01

The purpose of this study was to identify the relationship among critical thinking skill, gender and motivation in 9th grade students of Junior High School in Kuningan. This descriptive study used purposive sampling that comprised 110 ninth grade students taken from three junior high school that has good computer literacy and use 2013 curriculum. The data were obtained through Science Virtual Test on living things and environmental sustainability theme, respondent identity, and science motivation questionnaire (SMQ). Female students scored highest on generating purpose skill (M = 73.81), while male students performed better on generating implication and consequences skill (M = 78.01) where both groups differed significantly (p = 0.011). Students scored highest on generating purpose skill for high and moderate motivation group, while for the lowest score, moderate and low motivation group performed it on making assumption skill. Additionally, some critical thinking elements differed significantly by motivation to learn science. Despite, there was no correlation between students’ critical thinking and motivation (r = 0.155, p > 0.05). The finding indicated that students’ critical thinking is not differed by gender and not affected by motivation to learn science.

What about Th1/Th2 in cutaneous leishmaniasis vaccine discovery?

Directory of Open Access Journals (Sweden)

Campos-Neto A.

2005-01-01

Full Text Available The T helper cell type 1 (Th1 response is essential to resist leishmaniasis, whereas the Th2 response favors the disease. However, many leishmanial antigens, which stimulate a Th1 immune response during the disease or even after the disease is cured, have been shown to have no protective action. Paradoxically, antigens associated with an early Th2 response have been found to be highly protective if the Th1 response to them is generated before infection. Therefore, finding disease-associated Th2 antigens and inducing a Th1 immune response to them using defined vaccination protocols is an interesting unorthodox alternative approach to the discovery of a leishmania vaccine.

Selected contributions from the 9th International Conference on Tidal Sedimentology, November 2015, Puerto Madryn, Patagonia, Argentina: an introduction

Science.gov (United States)

Scasso, Roberto A.; Cuitiño, José I.

2017-08-01

This special issue of Geo-Marine Letters presents selected contributions from the 9th International Conference on Tidal Sedimentology held on 17-19 November 2015 in Puerto Madryn, Chubut Province, Patagonia, Argentina. The guest editors are the conference organizers Roberto A. Scasso and José I. Cuitiño. Gerardo M. Perillo was the head of the Scientific Committee. The conferences on tidal sedimentology have been traditionally held every 4 years. However, only 3 years separated the last conference held in Caen (France, 2012) from this conference. Increasing numbers of contributions and the growing interest in tidal sedimentation have been the reasons for shortening the inter-conference period. The 2015 conference served as a discussion forum focusing on advances in modern and ancient tidal sedimentation at different locations worldwide. The papers presented in this Special Issue provide a selective view of the latest research results, the main topics dealing with tidal hydrodynamics and sediment transport, tidal coastal morphodynamics, modern and ancient tidal sedimentation, geotechnical processes in tidal environments, and tidal basins, facies and reservoirs.

'HTA for Crisis': sharing experiences during the 7th EBHC Symposium.

Science.gov (United States)

Wladysiuk, Magdalena; Tabor, Anna; Godman, Brian

2013-02-01

The Central and Eastern European Society of Technology Assessment in Health Care was founded in Krakow, Poland in 2003. On October 8th and 9th, the 7th symposium took place titled 'HTA for Crisis'. This meeting was attended by over 250 decision makers, evidence-based specialists, healthcare managers, commercial company personnel and experts. The symposium was principally divided into four main themes: insurance in times of crisis; importance of pricing of health services in times of crisis; managing welfare benefits in times of crisis and Health Technology Assessment in crisis-laden countries. The symposium finished by debating potential ways forward for healthcare systems in times of crisis.

Proceedings of the 4th Symposium on Laser Spectroscopy

International Nuclear Information System (INIS)

1996-11-01

This proceedings contains articles of the 4th Symposium on Laser Spectroscopy. It was held on Nov 8-9, 1996 in Taejeon, Korea. The main topics are as follows: Laser Isotope, Laser Spectroscopy, Laser Fusion, Laser Applications and so on. (Yi, J. H.)

Determination of 228Th, 230Th, and 232Th in environmental samples from uranium mining and milling operations

International Nuclear Information System (INIS)

Durham, R.W.; Joshi, S.R.

1979-01-01

A method is described for the determination of 228 Th, 230 Th, and 232 Th in environmental samples from uranium mining and milling operations. The analytical procedure is based on the direct determination of 228 Th in the sample by high resolution γ-spectrometry followed by extraction and purification of the thorium fraction using high molecular weight amines and an anion-exchange technique, respectively, prior to α-spectrometry to determine isotopic ratios. The lowest level of detection for each thorium isotope is 0.01 pCi/g for solid samples and 20 pCi/l for aqueous samples. Replicate analyses of a typical mine waste stream gave a standard deviation of +-3% for 228 Th. Standard deviations of the 230 Th and 232 Th increased to +-11% apparently due to traces of 210 Po interfering in the α-spectrometry. (author)

Distribution of U and Th in Growth Zones of Manganese Nodules

DEFF Research Database (Denmark)

Kunzendorf, Helmar; Friedrich, G. H. W.

1976-01-01

Growth zones and individual sublayers from one manganese nodule and three manganese crusts from an area south of Hawaii were analysed for U and Th by the delayed-neutron counting technique. The concentrations of uranium and thorium in the manganese nodule are highest in the outermost zone on top...... to the sediment which has low concentrations of Fe, relative to the zone last exposed to sea water, has also low U contents (2.7 ppm). Th concentrations are higher in the outermost zone on top of the nodule (40 to a maximum of 130 ppm) than in the zone last exposed to the sediment (about 20 ppm Th). Manganese...... crusts contain up to 9 ppm U in the outermost zones last exposed to the sea water. They also have higher concentrations of Th (up to 64 ppm) relative to the inner zones of the crust growing on altered andesitic rock, which contains about 8 ppm U and about 26 ppm Th as an average....

Elevated Ratio of Th17 Cell-Derived Th1 Cells (CD161(+)Th1 Cells) to CD161(+)Th17 Cells in Peripheral Blood of Early-Onset Rheumatoid Arthritis Patients.

Science.gov (United States)

Kotake, Shigeru; Nanke, Yuki; Yago, Toru; Kawamoto, Manabu; Kobashigawa, Tsuyoshi; Yamanaka, Hisashi

2016-01-01

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by the destruction of articular cartilage and bone with elevated levels of proinflammatory cytokines. It has been reported that IL-17 and Th17 cells play important roles in the pathogenesis of RA. Recently, plasticity in helper T cells has been demonstrated; Th17 cells can convert to Th1 cells. It remains to be elucidated whether this conversion occurs in the early phase of RA. Here, we tried to identify Th17 cells, Th1 cells, and Th17 cell-derived Th1 cells (CD161(+)Th1 cells) in the peripheral blood of early-onset RA patients. We also evaluated the effect of methotrexate on the ratio of Th17 cells in early-onset RA patients. The ratio of Th17 cell-derived Th1 cells to CD161(+)Th17 cells was elevated in the peripheral blood of early-onset RA patients. In addition, MTX reduced the ratio of Th17 cells but not Th1 cells. These findings suggest that IL-17 and Th17 play important roles in the early phase of RA; thus, anti-IL-17 antibodies should be administered to patients with RA in the early phase.

Thyroid hormone reduces PCSK9 and stimulates bile acid synthesis in humans[S

Science.gov (United States)

Bonde, Ylva; Breuer, Olof; Lütjohann, Dieter; Sjöberg, Stefan; Angelin, Bo; Rudling, Mats

2014-01-01

Reduced plasma LDL-cholesterol is a hallmark of hyperthyroidism and is caused by transcriptional stimulation of LDL receptors in the liver. Here, we investigated whether thyroid hormone (TH) actions involve other mechanisms that may also account for the reduction in LDL-cholesterol, including effects on proprotein convertase subtilisin/kexin type 9 (PCSK9) and bile acid synthesis. Twenty hyperthyroid patients were studied before and after clinical normalization, and the responses to hyperthyroidism were compared with those in 14 healthy individuals after 14 days of treatment with the liver-selective TH analog eprotirome. Both hyperthyroidism and eprotirome treatment reduced circulating PCSK9, lipoprotein cholesterol, apoB and AI, and lipoprotein(a), while cholesterol synthesis was stable. Hyperthyroidism, but not eprotirome treatment, markedly increased bile acid synthesis and reduced fibroblast growth factor (FGF) 19 and dietary cholesterol absorption. Eprotirome treatment, but not hyperthyroidism, reduced plasma triglycerides. Neither hyperthyroidism nor eprotirome treatment altered insulin, glucose, or FGF21 levels. TH reduces circulating PSCK9, thereby likely contributing to lower plasma LDL-cholesterol in hyperthyroidism. TH also stimulates bile acid synthesis, although this response is not critical for its LDL-lowering effect. PMID:25172631

Case report

African Journals Online (AJOL)

ebutamanya

28 oct. 2015 ... thérapeutique. Conflits d'intérêts les auteurs ne déclarent aucun conflit d''intérêt. Contributions des auteurs. Tous les auteurs ont lu et approuvé la version finale du manuscrit. Références. 1. Barker JM1, Liu E. Celiac disease: pathophysiology, clinical manifestations, and associated autoimmune conditions.

9. Biennial session of nuclear physics

International Nuclear Information System (INIS)

1987-03-01

As every two years the 9th biennial session of nuclear physics shall try to make a survey of the recent experimental developments as well as the evolution of the theoretical ideas in Nuclear Physics. Communications are indexed and analysed separately

Computer Games : 5th Workshop on Computer Games, CGW 2016, and 5th Workshop on General Intelligence in Game-Playing Agents, GIGA 2016, held in conjunction with the 25th International Conference on Artificial Intelligence, IJCAI 2016, New York, USA, July 9-10, 2016, Revised selected papers

NARCIS (Netherlands)

Cazenave, Tristan; Winands, Mark H. M; Edelkamp, Stefan; Schiffel, Stephan; Thielscher, Michael; Togelius, Julian

2017-01-01

This book constitutes the refereed proceedings of the 5th Computer Games Workshop, CGW 2016, and the 5th Workshop on General Intelligence in Game-Playing Agents, GIGA 2016, held in conjunction with the 25th International Conference on Artificial Intelligence, IJCAI 2016, in New York, USA, in July

Th1-Th17 Ratio as a New Insight in Rheumatoid Arthritis Disease.

Science.gov (United States)

Bazzazi, Hadi; Aghaei, Mehrdad; Memarian, Ali; Asgarian-Omran, Hossein; Behnampour, Nasser; Yazdani, Yaghoub

2018-02-01

The Th17, Th1 and dual Th17/Th1 cells are important players in rheumatoid arthritis (RA) disease. To assess their roles, the frequency and impact of these cells were investigated in patients with different disease activity. In 14 new cases and 41 established RA patients in comparison with 22 healthy controls, the percentages of Th17, Th1 and dual Th17/Th1 cells were determined by flow-cytometry and their correlations were investigated with disease activity score (DAS28). Moreover, serum levels of IL-6 and IL-17 as inducer and functional cytokines for Th17 were investigated. Finally, serum levels of anti citrullinated protein antibody (ACPA) and rheumatoid factor (RF) were assessed. Percentage of Th17 cells in RA patients were increased in comparison with healthy controls (pTh1 cells in RA patients were less than healthy group (pTh17/Th1 cell only in new cases of RA were more than healthy control groups (pTh1/Th17 ratio in RA patients is statistically different with healthy control group (pTh1/Th17 ratio in RA patient suggested a new paradigm in the field of autoimmune disease and indicated that imbalance or plasticity between these subsets can be important in progress, diagnosis and therapy of RA disease.

Quantitative Proteomics of Gut-Derived Th1 and Th1/Th17 Clones Reveal the Presence of CD28+ NKG2D- Th1 Cytotoxic CD4+ T cells.

Science.gov (United States)

Riaz, Tahira; Sollid, Ludvig Magne; Olsen, Ingrid; de Souza, Gustavo Antonio

2016-03-01

T-helper cells are differentiated from CD4+ T cells and are traditionally characterized by inflammatory or immunosuppressive responses in contrast to cytotoxic CD8+ T cells. Mass-spectrometry studies on T-helper cells are rare. In this study, we aimed to identify the proteomes of human Th1 and Th1/Th17 clones derived from intestinal biopsies of Crohn's disease patients and to identify differentially expressed proteins between the two phenotypes. Crohn's disease is an inflammatory bowel disease, with predominantly Th1- and Th17-mediated response where cells of the "mixed" phenotype Th1/Th17 have also been commonly found. High-resolution mass spectrometry was used for protein identification and quantitation. In total, we identified 7401 proteins from Th1 and Th1/Th17 clones, where 334 proteins were differentially expressed. Major differences were observed in cytotoxic proteins that were overrepresented in the Th1 clones. The findings were validated by flow cytometry analyses using staining with anti-granzyme B and anti-perforin and by a degranulation assay, confirming higher cytotoxic features of Th1 compared with Th1/Th17 clones. By testing a larger panel of T-helper cell clones from seven different Crohn's disease patients, we concluded that only a subgroup of the Th1 cell clones had cytotoxic features, and these expressed the surface markers T-cell-specific surface glycoprotein CD28 and were negative for expression of natural killer group 2 member D. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

Modelo natural de dicotomía TH1-TH2: La enfermedad de Hansen Th1-TH2 balance. Natural model: Hansen'disease

Directory of Open Access Journals (Sweden)

N. L Vaquero

2010-09-01

Full Text Available La enfermedad de Hansen producida por el Mycobacterium leprae, es una enfermedad infecciosa cuyo amplio espectro clínico e inmunopatológico se correlaciona con los diferentes patrones de respuesta Th1/Th2. La activación preferencial de esas subpoblaciones de linfocitos T CD4 juega un rol importante en su patogenia y constituye un modelo natural de esa dicotomía de la respuesta inmune. Ambas formas polares de la lepra presentan un perfil definido de secreción de citoquinas: Th1 (IL2 e IFN? en el polo tuberculoide y Th2 (IL4, IL5, IL10 en el polo lepromatoso. En el primer caso, la respuesta celular adecuada estimula la activación macrofágica y lleva a la destrucción del bacilo. Las lesiones son escasas y limitadas a la piel y nervios periféricos. En el segundo en cambio, la respuesta celular es casi nula y los bacilos se multiplican descontroladamente dentro de los macrófagos, llevando a la diseminación de las lesiones y afectación de otros órganos. La inmunidad humoral está exacerbada y hay un alto nivel de anticuerpos que no pueden eliminar el germen intracelular. Los factores que determinan la diferenciación hacia una respuesta Th1 ó Th2 no se han esclarecido totalmente. Se han postulado varias hipótesis que hacen referencia a factores genéticos, prevalencia de citoquinas en el microambiente celular, disfunción macrofágica; alteración en los receptores Toll de la inmunidad innata, en la expresión de moléculas coestimulatorias, etc En los últimos años se han descubierto nuevas subpoblaciones de linfocitos, (CD4+ CD25+, Tr1, Th3 y Th17 que estarían implicadas en la desregulación de estas respuestas inmunes.Hansen' disease, caused by Mycobacterium leprae, is an infectious illness whose wide clinical and immunopathologic spectrum correl with different Th1/Th2 responses patterns. The prefferencial activation of the CD4 T cells subset play an important rol in it's pathogenia and provides a natural model of that balance

THE 4th SCHIZOPHRENIA INTERNATIONAL RESEARCH SOCIETY CONFERENCE, 5–9 APRIL 2014, FLORENCE, ITALY: A summary of topics and trends

Science.gov (United States)

Abayomi, Olukayode; Amato, Davide; Bailey, Candace; Bitanihirwe, Byron; Bowen, Lynneice; Burshtein, Shimon; Cullen, Alexis; Fusté, Montserrat; Herrmann, Ana P; Khodaie, Babak; Kilian, Sanja; Lang, Qortni A; Manning, Elizabeth E; Massuda, Raffael; Nurjono, Milawaty; Sadiq, Sarosh; Sanchez-Gutierrez, Teresa; Sheinbaum, Tamara; Shivakumar, Venkataram; Simon, Nicholas; Spiteri-Staines, Anneliese; Sirijit, Suttajit; Toftdahl, Nanna Gilliam; Wadehra, Sunali; Wang, Yi; Wigton, Rebekah; Wright, Susan; Yagoda, Sergey; Zaytseva, Yuliya; O’Shea, Anne; DeLisi, Lynn E.

2015-01-01

The 4th Schizophrenia International Research Society Conference was held in Florence, Italy, April 5–9, 2014.and this year had as its emphasis, “Fostering Collaboration in Schizophrenia Research”. Student travel awardees served as rapporteurs for each oral session, summarized the important contributions of each session and then each report was integrated into a final summary of data discussed at the entire conference by topic. It is hoped that by combining data from different presentations, patterns of interest will emerge and thus lead to new progress for the future. In addition, the following report provides an overview of the conference for those who were present, but could not participate in all sessions, and those who did not have the opportunity to attend, but who would be interested in an update on current investigations ongoing in the field of schizophrenia research. PMID:25306204

Sensitivity of Botrytis cinerea Isolates Against Some Fungicides ...

African Journals Online (AJOL)

Desen

2012-01-26

Jan 26, 2012 ... In:15 th. Int. Botrytis Sym. 31 th May–4 th June Cadiz, Spain. Vallejo I, Carbu M, Rebordinos L, Cantoral JM (2003). Virulence of. Botrytis cinerea strains on two grapevine varieties in South-Western. Spain. Biologia Bratislava. 58: 1067-1074. Walter M, Harris-Virgin P, Morgan C, Stanley J, Body-Wilson KSH.

Comparaison de populations de carpe commune (Cyprinus carpio à taille commerciale : intérêt d'une approche globale

Directory of Open Access Journals (Sweden)

PEREIRA V.

1999-07-01

Une discrimination géographique des populations est possible mais elle repose sur une approche globale intégrant l'ensemble des paramètres. Les différences semblent essentiellement liées aux conditions environnementales et permettent de distinguer les lots issus des régions où l'élevage est plus intensif et traditionnellement centré sur la carpe (Dombes, Forez, Lorraine et les lots correspondant à un élevage plus extensif et davantage orienté vers le marché du repeuplement (Allier, Brenne, Poitou-Charentes.

Intérprete surdo de língua de sinais brasileira: o novo campo de tradução / interpretação cultural e seu desafio

Directory of Open Access Journals (Sweden)

Ana Regina e Souza Campello

2014-07-01

  Esse artigo é o resultado da pesquisa que trata da nova modalidade de tradução/interpretação de línguas de sinais dos intérpretes Surdos, observando a norma surda (STONE, 2009 apud SOUZA, 2010. Recentemente surgiu esse novo campo de tradução no contexto educacional do ensino a distância: o da tradução e interpretação do ator/tradutor e finalmente e intérprete de uma língua de sinais para outra língua de sinais (SEGALA, 2010; SOUZA, 2010. Estas atividades de tradução e interpretação têm sido desempenhadas por Surdos bilíngues intermodais. Exatamente por representar um novo campo de estudo, este artigo apresenta a sua constituição.

Chronology of 3rd–5th Century Female Graves from Tarasovo Burial Ground

Directory of Open Access Journals (Sweden)

Goldina Rimma D.

2017-07-01

Full Text Available The article represents the concluding part a series of works by the authors on the dating of burials from the unique 1st–5th century Tarasovo burial ground in the Middle Kama region. The first article was dedicated to the chronology of graves dating back to the early Nyrgynda stage (1st–2nd centuries of this monument. The second and third publications feature an analysis of the chronology of 3rd–5th century male burials. The present work describes 160 female burials of 3rd–5th centuries analyzed from the perspective of chronology. Similarly to previous research, the three main methods employed by the authors of this research include those of formal typology, cultural stratigraphy and the nearest neighbour method. A total of 12 chronological groups were singled out as a result: 1st half of 3rd century A.D. (group 1; 2nd half of 3rd century (2; 3rd century (3; 4th century (group 4; 2nd half of 3rd–4th centuries (5а; 3rd–4th centuries (5б; 1st half of 5th century (6; 2nd half of 5th century (7; 5th century (group 8; 2nd half of 4th–5th centuries (9; 4th–5th centuries (10; 2nd half of 3rd–5th centuries

L'effet pro-concurrentiel de l'intégration européenne:

DEFF Research Database (Denmark)

Bellone, Flora; Musso, Patrick; Nesta, Lionel

En situation de concurrence pure et parfaite, les décisions par les entreprises de quantité produites et d'utilisation des facteurs s'effectuent en égalisant le prix du marché de bien final avec le coût marginal. En situation de concurrence imparfaite, cette égalisation n'est plus respectée, les...... firmes ayant intérêt d'utiliser leur pouvoir de marché pour fixer un prix au-delà de leur coût marginal. Dans cet article, nous mesurons les taux de marge, définis comme l'écart en pourcentage entre le prix de vente et le coût marginal, à partir de données d'entreprises pour 14 industries manufacturières...... françaises de 1986 à 2004. Nous observons que le taux de marge moyen, sur l'ensemble de la période et sur l'ensemble des industries, est de 13,8%, ce qui est légèrement supérieur au Royaume-Uni.  Nous trouvons que la mise en place du marché commun a conduit à une diminution de 4 à 5% des marges, alors que l...

Autobiographie de A Lai: auto-thérapie de la souffrance par l’écriture autobiographique

Directory of Open Access Journals (Sweden)

Yue Yue

2010-02-01

Full Text Available Connu par son obtention en 2005 du prix littéraire le plus prestigieux de la Chine pour son roman Chen'ai luoding (la poussière tombe qui pourtant mit du temps à s’imposer, le romancier d’expression chinoise A Lai, né en 1959, est l’un de ces auteurs tibétains sinophones par obligation. Il puise toujours son inspiration dans une souffrance qui l’accompagne depuis son enfance. En effet deux courts romans, respectivement publiés en 1987 et en 1988, et un long poème édité en 1989 témoignent d’un parcours douloureux jusqu’à la trentaine. L’expérience de A Lai est exceptionnelle dans la littérature d’expression chinoise, peu habituée à ce type d’auto-thérapie littéraire manifeste dans son œuvre romanesque et son œuvre poétique complémentaires et dont la dimension personnelle n’exclut pas l’intérêt d’un témoignage social.

Intégration d'un bouchon du trajectographe au silicium de l'expérience CMS au LHC et étude du potentiel de découverte de résonances se désintégrant en paires de quarks top

CERN Document Server

Chabert, Eric

2008-01-01

La première partie de cette thèse porte sur l'intégration d'un bouchon du trajectographe au silicium de l'expérience CMS. Les procédures mises en œuvre et les tests qui ont permis d'aboutir à la qualification du système de détection sont présentés dans ce document. La deuxième partie est dédiée à la recherche de nouvelle physique dans le secteur du quark top. Une des voies les plus prometteuses consiste à rechercher une résonance dans la distribution en masse invariante des paires de quarks top. Une analyse réalisée en simulation complète dans le canal lepton+jets montre qu'à l'échelle du TeV, des processus de quelques centaines de fb à 1 pb pourraient être observés lors des premières années de prises de données.

High resolution 10Be and 230Th profiles in DSDP site 580

International Nuclear Information System (INIS)

Eisenhauer, A.; Mangini, A.; Segl, M.; Beer, J.; Bonani, G.; Suter, M.; Woelfli, W.

1987-01-01

10 Be and 230 Th profiles were measured at Site 580 at a depth of 20 m ( 230 Th and 10 Be) and 80 m ( 10 Be), corresponding to 360 ka and 1.5 Ma, respectively, with a resolution of approx. 5000 a. The radiometric sediment accumulation rates of 6.2 cm/ka (±25%) agree well with the average for the last 730 ka (via paleomagnetic stratigraphy). Age corrected concentrations of 10 Be range from 2 to 7x10 9 atoms/g (average 3.5±1). The variations of the 10 Be concentrations can be explained by changes in the sediment supply during different climatic conditions. The maxima and the minima of 10 Be follow the fluctuations of excess 230 Th in the core section during the last 360 ka. Fluxes of both 10 Be and 230 Th exceed production and vary remarkably throughout time suggesting enhanced scavenging by bioproductivity. At the Brunhess-Matuyama boundary we observe a maximum of 10 Be (6.0±0.3x10 9 atoms/g, corresponding to 2.5 σ deviation from the average value). However, the observed large fluctuations of Be-10 throughout the core profile make it difficult to interprete this particular maximum. (orig.)

Os intérpretes e a formação do Brasil: os quatro primeiros séculos de uma história esquecida

Directory of Open Access Journals (Sweden)

Dennys Silva-Reis

2016-09-01

Full Text Available http://dx.doi.org/10.5007/2175-7968.2016v36n3p81 A formação histórica do Brasil muito deveu ao trabalho indispensável dos intérpretes desde o chamado “descobrimento” até bem avançado o século XIX. Neste artigo, destacamos a necessidade de conceder maior visibilidade aos intérpretes e à sua contribuição para a história cultural e linguística do Brasil, de modo que se comece a traçar um retrato mais fidedigno das complexas relações entre línguas, povos e culturas que caracterizaram os quatro primeiros séculos dessa história. Para tanto, destacamos o papel desses agentes culturais para uma reescrita da história da tradução no Brasil. Estes que permanecem marginalizados ou mesmo invisíveis na historiografia geral se tornam aqui agentes primordiais para a formação histórica do Brasil em todas as suas etapas.

Estimation of radionuclide concentration of 238U, 226Ra, 232Th in air in Wuhan city

International Nuclear Information System (INIS)

Shi Jinhua; Chen Changhua

1989-01-01

The concentrations of 238 U, 226 Ra and 232 Th in air in Wuhan area were estimated by assuming that they originate from resuspended particles of soil and investigating the dust content in air and the concentrations of these radionuclides in soil. 60 soil samples were collected from April to October, 1984, and 7346 air dust samples during 1981-1985. The estimated mean air concentrations of 238 U, 226 Ra and 232 Th were 24.0 x 10 -9 , 18.9 x 10 -9 and 28.7 x 10 -9 , Bq/L, respectively. Their highest values were observed of 30.4 x 10 -9 , 23.9 x 10 -9 and 36.2 x 10 -9 Bq/L in 1983. Seasonal change of the concentrations was clear as shown in the data of 1984 and 1985, which was related to the meterological conditions. Among the 6 districts of Wuhan city, the highest concentration was in Qingshan and the lowest in Wuchang

A Tool for Conceptualising in PSS development

DEFF Research Database (Denmark)

Matzen, Detlef; McAloone, Timothy Charles

2006-01-01

This paper introduces a tool for conceptualising in the development of product/servicesystems (PSS), based upon the modelling of service activities. Our argumentation is built on two previous articles by the same author, previously presented at the 16. Symposium “Design for X” [1] and the 9th Int...... the integrated consideration of the customers’ activities, possible PSS offerings and beneficial partnering options (i.e. between different supplier companies) within the delivery value chain.......This paper introduces a tool for conceptualising in the development of product/servicesystems (PSS), based upon the modelling of service activities. Our argumentation is built on two previous articles by the same author, previously presented at the 16. Symposium “Design for X” [1] and the 9th...... International Design Conference [2]. In this contribution, we take the step from a fundamental understanding of the phenomenon to creating a normative exploitation of this understanding for PSS concept development. The developed modelling technique is based on the Customer Activity Cycle (CAC) model...

Usage of Metaphors in Turkish Language Textbooks Used at 6th, 7th and 8th Grades

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Esra Karakas

2013-05-01

Full Text Available The word “Metaphor”, which is equivalent to the terms “istiare” in Arabic or “eğretileme, transfer of idioms” in Turkish, consists of two parts. “Meta” means “later” or “with” whereas “phora” means transfer or conveyance of word. In the recent years metaphor has been the subject and focuses of several studies, and is used to express a concept or situation with another concept or situation. Starting from 1980s, researchers have studied metaphor and concurrently they examined usage of language. It is now been believed that using metaphors is appropriate in order to be able to understand any phenomenon. Metaphor can be used in encouraging learning and improving creative thinking; it can also provide hints for in-the-class methods, techniques and situations. In this context, metaphors are also essential components for Turkish language textbooks. The purpose of this study is to detect the uses of metaphor in Turkish language textbooks of 6th, 7th and 8th grade students. For this purpose the Turkish language textbooks of 6th, 7th and 8th grade students prepared by the Ministry of National Education (MEB were examined with “content analysis method. Considering that metaphors are effective in learning and improving creative thinking, the importance of using metaphors in textbooks is beyond discussion. The data collected throughout this study show that the metaphors detected in 7th and 8th grade Turkish language textbooks are less in number compared to those found in 6th grade Turkish language textbooks. Another important conclusion is that distribution of metaphors among units is not even. The conclusion of the study is that Turkish language textbooks are not prepared in a sensitive and choosy manner with this respect.

The Effects of Problem Based Scenarios on 9th Grade Students’ Attitudes towards Chemistry, Laboratory Anxiety, and Perceptions of Problem Solving

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Faik Özgür Karataş

2016-11-01

Full Text Available Students were expected to construct knowledge, to criticize and to generate new ideas. PISA results in science field are disappointing. Turkish students’ performance on the questions that requires higher order thinking and problem solving skills is very poor. This indicates that learning environment should be redesigned to fulfill these lacking skills. Scenario based learning is one of the approaches that promotes problem solving skills by enabling active involvement of students into solving everyday problems. The purpose of this study is to examine effects of the problem based scenarios with worksheets on 9th grade students’ attitudes towards chemistry, laboratory anxiety, and problem solving perceptions. Pre- and post-test comparison with t-test showed that there is no significant difference before and after the treatment for none of the variables even though scores were higher after the treatment. On the other hand, data from observations and students interviews implied positive effect of the treatment.

Randomized Phase II Trial of Gemcitabine Plus TH-302 Versus Gemcitabine in Patients With Advanced Pancreatic Cancer.

Science.gov (United States)

Borad, Mitesh J; Reddy, Shantan G; Bahary, Nathan; Uronis, Hope E; Sigal, Darren; Cohn, Allen L; Schelman, William R; Stephenson, Joe; Chiorean, E Gabriela; Rosen, Peter J; Ulrich, Brian; Dragovich, Tomislav; Del Prete, Salvatore A; Rarick, Mark; Eng, Clarence; Kroll, Stew; Ryan, David P

2015-05-01

TH-302 is an investigational hypoxia-activated prodrug that releases the DNA alkylator bromo-isophosphoramide mustard in hypoxic settings. This phase II study (NCT01144455) evaluated gemcitabine plus TH-302 in patients with previously untreated, locally advanced or metastatic pancreatic cancer. Patients were randomly assigned 1:1:1 to gemcitabine (1,000 mg/m(2)), gemcitabine plus TH-302 240 mg/m(2) (G+T240), or gemcitabine plus TH-302 340 mg/m(2) (G+T340). Randomized crossover after progression on gemcitabine was allowed. The primary end point was progression-free survival (PFS). Secondary end points included overall survival (OS), tumor response, CA 19-9 response, and safety. Two hundred fourteen patients (77% with metastatic disease) were enrolled between June 2010 and July 2011. PFS was significantly longer with gemcitabine plus TH-302 (pooled combination arms) compared with gemcitabine alone (median PFS, 5.6 v 3.6 months, respectively; hazard ratio, 0.61; 95% CI, 0.43 to 0.87; P = .005; median PFS for metastatic disease, 5.1 v 3.4 months, respectively). Median PFS times for G+T240 and G+T340 were 5.6 and 6.0 months, respectively. Tumor response was 12%, 17%, and 26% in the gemcitabine, G+T240, and G+T340 arms, respectively (G+T340 v gemcitabine, P = .04). CA 19-9 decrease was greater with G+T340 versus gemcitabine (-5,398 v -549 U/mL, respectively; P = .008). Median OS times for gemcitabine, G+T240, and G+T340 were 6.9, 8.7, and 9.2 months, respectively (P = not significant). The most common adverse events (AEs) were fatigue, nausea, and peripheral edema (frequencies similar across arms). Skin and mucosal toxicities (2% grade 3) and myelosuppression (55% grade 3 or 4) were the most common TH-302-related AEs but were not associated with treatment discontinuation. PFS, tumor response, and CA 19-9 response were significantly improved with G+TH-302. G+T340 is being investigated further in the phase III MAESTRO study (NCT01746979). © 2014 by American Society of

Relics of continental lithosphere in the atlantic by data of (Th/U)th, (Th/U)pb, and K/Ti systematics

International Nuclear Information System (INIS)

Titayeva, N.A.; Mironov, Y.

1996-01-01

The problem of mantle heterogeneity of the Atlantic Ocean has been investigated. Th/U ratio is a sensitive geochemical tracer. This ratio can be calculated from 232Th/230Th or from 208Pb/206Pb since 230Th and 206Pb are decay product of 238U and 208Pb is a product of 232Th decay. The former way to get Th/U ratio is valid for quaternary volcanic rocks because of the relatively short 230Th half life (80000 years), the latter way gives an integral quantity characterizing the pre-oceanic history beginning from the onset of earth formation and ending about 150 million years ago. Clear distinctions between ''depleted oceanic'' and ''enriched continental'' reservoirs have been drawn from comparative analysis of rocks. (A.C.)

X-ray spectral study of the Th6p,5f electron states in ThO2 and ThF4

International Nuclear Information System (INIS)

Teterin, Y.A.; Nikitin, A.S.; Teterin, A.Y.; Ivanov, K.E.; Utkin, I.O.; Nerehov, V.A.; Ryzhkov, M.V.; Vukchevich, I.J.

2002-01-01

The study of the Th6p,5f electron states in Th, ThO 2 and ThF was carried out on the basis of the X-ray photoelectron fine spectral structure parameters in the binding energy range of 0-∼ 1000 eV, X-ray O 4,5 (Th) emission spectra of the shallow (0-∼50 eV) electrons and results of theoretical calculations. As a result, despite the absence of the Th5f electrons in thorium atoms, the Th5f atomic orbitals were established to participate in the formation of molecular orbitals in thorium dioxide and tetrafluoride. In the MO LCAO approximation this allowed to suggest the possible existence of filled Th5f electronic states in thorium compounds. On the basis of the X-ray O 4,5 (Th) emission spectral structure parameters the effective formation of the inner valence molecular orbitals in the studied compounds was confirmed. (authors)

Modeling of Teaching 5th-7th-Grade Boys Physical Exercises

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Т. Г. Абдулхалікова

2017-09-01

Full Text Available The research objective is to determine the effectiveness of orthogonal variants of teaching 5th-7th graders physical exercises. Materials and methods. The participants in the research were boys of the 5th grade (n = 32, 6th grade (n = 40, 7th grade (n = 52. To achieve the tasks set, the research used the following methods: analysis of scientific and methodological literature; pedagogical testing, pedagogical observation, timing of educational tasks; pedagogical experiment, medical and biological research methods; methods of mathematical statistics, methods of mathematical experiment planning. In order to achieve the objective set, the research has studied the effect of different variants of the educational process structure, namely: the number of repetitions (х1 and rest intervals (х2 when learning the technique of performing physical exercises. The research has conducted a complete factor experiment of type 22. According to the experiment plan, the 5th-7th graders were divided into training groups. In total, there were 12 experimental groups organized. Research results. The analysis of the regression equations shows that the teaching of physical exercises to the 5th-7th-grade boys is mostly influenced by rest intervals between repetitions (х2. The number of repetitions (х1 has somewhat less influence. The interaction of these factors is insignificant when teaching physical exercises and becomes much more influential only when teaching a switch leg pull-over exercise (х1х2. Conclusions. To increase the effectiveness of teaching 5th-7th graders physical exercises, it is necessary to shorten rest intervals between repetition to 60 s and to reduce the number of repetitions to six. When teaching boys the switch leg pull-over exercise, rest intervals should be increased to 120 s and the number of repetitions — to twelve.

108TH ACCU Meeting

CERN Multimedia

2015-01-01

Agenda for the meeting to be held on Tuesday, 9 June 2015 at 9.15 a.m. in room Georges Charpak (Room F, 60-6-015): Chairperson's remarks Adoption of the agenda      Minutes of the previous meeting Report on services from GS Department a. General Services b. Collaboration between CERN and HUG Report on services from IT Department 50th anniversary of the CERN Bulletin News from the CERN Management Progress on Health Insurance for Users Users’ Office News Reports from ACCU representatives on other Committees a. Restaurants' Supervisory committee Matters arising Any Other Business Agenda for the next meeting   Anyone wishing to raise any points under “Any Other Business” is invited to send them to the Chairperson in writing or by e-mail to ACCU.Secretary@cern.ch. Michael Hauschild (Secretary) ACCU is a forum for discussion between the CERN Management and representatives of the CERN Us...

Potential pathogenetic role of Th17, Th0, and Th2 cells in erosive and reticular oral lichen planus.

Science.gov (United States)

Piccinni, M-P; Lombardelli, L; Logiodice, F; Tesi, D; Kullolli, O; Biagiotti, R; Giudizi, Mg; Romagnani, S; Maggi, E; Ficarra, G

2014-03-01

The role of Th17 cells and associated cytokines was investigated in oral lichen planus. 14 consecutive patients with oral lichen planus were investigated. For biological studies, tissues were taken from reticular or erosive lesions and from normal oral mucosa (controls) of the same patient. mRNA expression for IL-17F, IL-17A, MCP-1, IL-13, IL-2, IL-10, IL-1β, RANTES, IL-4, IL-12B, IL-8, IFN-γ, TNF-α, IL-1α, IL-18, TGF-β1, IL-23R, IL-7, IL-15, IL-6, MIG, IP-10, LTB, VEGF, IL-5, IL-27, IL-23A, GAPDH, PPIB, Foxp3, GATA3, and RORC was measured using the QuantiGene 2.0. Results showed that Th17-type and Th0-type molecules' mRNAs, when compared with results obtained from tissue controls, were increased in biopsies of erosive lesions, whereas Th2-type molecules' mRNAs were increased in reticular lesions. When the CD4+ T-cell clones, derived from oral lichen planus tissues and tissue controls, were analyzed, a higher prevalence of Th17 (confirmed by an increased CD161 expression) and Th0 CD4+ T clones was found in erosive lesions, whereas a prevalence of Th2 clones was observed in reticular lesions. Our data suggest that Th17, Th0, and Th2 cells, respectively, may have a role in the pathogenesis of erosive and reticular oral lichen planus. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

TNF-α inhibitors reduce the pathological Th1 -Th17 /Th2 imbalance in cutaneous mesenchymal stem cells of psoriasis patients.

Science.gov (United States)

Campanati, Anna; Orciani, Monia; Lazzarini, Raffaella; Ganzetti, Giulia; Consales, Veronica; Sorgentoni, Giulia; Di Primio, Roberto; Offidani, Annamaria

2017-04-01

Psoriasis is a disease characterized by an imbalance between Th 1 and Th 17 and Th 2 inflammatory axes, in which cutaneous mesenchymal stem cells (MSCs) are early involved, as they show a greater relative expression of several genes encoding for Th 1 and Th 17 cytokines. Therapeutic implications of TNF-α inhibitors on differentiated skin cells have been largely described in psoriasis; however, their effects on MSCs derived from patients with psoriasis have been only partially described. The aim of this work was to evaluate the effect of TNF-α inhibitors on cytokine milieu expressed by MSCs isolated from the skin of patients with psoriasis. Resident MSCs from skin of patients with psoriasis and healthy subjects have been isolated, characterized and profiled by PCR and ELISA for the expression of 22 cytokines involved in Th 1 , Th 2 and Th 17 pathways, both before and after 12 weeks therapy with TNF-α inhibitors. The administration of TNF-α inhibitors for 12-weeks acts on MSCs as follows: it reduces the expression of several Th 1 -Th 17 cytokines whose levels are elevated at baseline (IL-6, IL-8, IL-12, IL-23A, IFN-γ, TNF-α, CCL2, CCL20, CXCL2, CXCL5, IL-17A, IL-17C, IL-17F, IL-21, G-CSF). Similarly, it enhances the expression of several Th 2 cytokines which are underexpressed at baseline (IL-2, IL-4, IL-5), reducing the expression of those overexpressed at baseline (TGF-β and IL-13). TNF-α inhibitors could contribute to reduce the pathological imbalance between the Th 1 -Th 17 vs Th 2 axis in MSCs of patients with psoriasis. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

‘‘Lend a Hand’’ Project Helps Students: Improved Spatial Visualization Skills Through Engaging in Hands-On 3-D Printed Prosthetics Project During a 9th Grade Engineering Course

OpenAIRE

Smith, Shaunna; Talley, Kimberly

2018-01-01

Research shows that high spatial ability is linked to success and persistence in STEM. Empirical investigations often report a gender gap in favor of male students. The purpose of this research study was to assess changes to 9th grade engineering students’ spatial visualization skills through engagement in a nine-week collaborative 3-D printed prosthetics project embedded within their existing ‘‘Beginning Concepts of Engineering’’ course curriculum. Using concurrent mixed methods, this study ...

Impairment of the Intrinsic Capability of Th1 Polarization in Irradiated Mice: A Close Look at the Imbalanced Th1/Th2 Response after Irradiation.

Science.gov (United States)

Chen, Renxiang; Wang, Yi-Wen; Fornace, Albert J; Li, Heng-Hong

2016-12-01

Two major CD4 + T-helper (Th) lineages are Th1 and Th2, and well balanced Th1/Th2 responses are essential for immune function. In previously published studies, it was reported that radiation induces a Th1/Th2 immune imbalance toward a Th2-dominant direction, and this imbalance may contribute to postirradiation immune dysfunction. The polarization of Th cells is driven by the cytokine milieu and controlled by intracellular regulatory pathways that respond to cytokine signaling. It is widely accepted that radiation induces cytokine aberration, however, the precise alterations of cytokines in various tissue environments have been difficult to evaluate. In addition, the effects of radiation on the intrinsic functions of Th cells remain uncharacterized. Therefore, how radiation affects Th1/Th2 balance remains somewhat unclear. To address this, we investigated the changes in the polarization capability of Th cells by isolating them from mice previously exposed to radiation and assessing the cells in an established in vitro Th polarization system. Our novel results demonstrate that prior exposure to radiation led to the persistent aberration of the inherent capability of Th cells to differentiate into Th1 and Th2 lineages. The parallel changes in expression of Th1-specific master transcription factors and the key genes in metabolic reprograming indicated that radiation affects the core components in Th1 polarization. While Th1 differentiation was impaired after irradiation, little adverse effect was observed in Th2 differentiation; both of these findings contribute to the known phenotypes of Th1/Th2 imbalance caused by radiation.

Role of Th1 and Th2 cells in autoimmune demyelinating disease

NARCIS (Netherlands)

Nagelkerken, L.

1998-01-01

Evidence is accumulating that Th1 cells play an important role in the development of multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE), whereas Th2 cells contribute to recovery from disease. A maj or determinant in the development of Th1 and Th2 cells is the type of

Quality improvement of International Classification of Diseases, 9th revision, diagnosis coding in radiation oncology: single-institution prospective study at University of California, San Francisco.

Science.gov (United States)

Chen, Chien P; Braunstein, Steve; Mourad, Michelle; Hsu, I-Chow J; Haas-Kogan, Daphne; Roach, Mack; Fogh, Shannon E

2015-01-01

Accurate International Classification of Diseases (ICD) diagnosis coding is critical for patient care, billing purposes, and research endeavors. In this single-institution study, we evaluated our baseline ICD-9 (9th revision) diagnosis coding accuracy, identified the most common errors contributing to inaccurate coding, and implemented a multimodality strategy to improve radiation oncology coding. We prospectively studied ICD-9 coding accuracy in our radiation therapy--specific electronic medical record system. Baseline ICD-9 coding accuracy was obtained from chart review targeting ICD-9 coding accuracy of all patients treated at our institution between March and June of 2010. To improve performance an educational session highlighted common coding errors, and a user-friendly software tool, RadOnc ICD Search, version 1.0, for coding radiation oncology specific diagnoses was implemented. We then prospectively analyzed ICD-9 coding accuracy for all patients treated from July 2010 to June 2011, with the goal of maintaining 80% or higher coding accuracy. Data on coding accuracy were analyzed and fed back monthly to individual providers. Baseline coding accuracy for physicians was 463 of 661 (70%) cases. Only 46% of physicians had coding accuracy above 80%. The most common errors involved metastatic cases, whereby primary or secondary site ICD-9 codes were either incorrect or missing, and special procedures such as stereotactic radiosurgery cases. After implementing our project, overall coding accuracy rose to 92% (range, 86%-96%). The median accuracy for all physicians was 93% (range, 77%-100%) with only 1 attending having accuracy below 80%. Incorrect primary and secondary ICD-9 codes in metastatic cases showed the most significant improvement (10% vs 2% after intervention). Identifying common coding errors and implementing both education and systems changes led to significantly improved coding accuracy. This quality assurance project highlights the potential problem

Validity of Students Worksheet Based Problem-Based Learning for 9th Grade Junior High School in living organism Inheritance and Food Biotechnology.

Science.gov (United States)

Jefriadi, J.; Ahda, Y.; Sumarmin, R.

2018-04-01

Based on preliminary research of students worksheet used by teachers has several disadvantages such as students worksheet arranged directly drove learners conduct an investigation without preceded by directing learners to a problem or provide stimulation, student's worksheet not provide a concrete imageand presentation activities on the students worksheet not refer to any one learning models curicullum recommended. To address problems Reviews these students then developed a worksheet based on problem-based learning. This is a research development that using Ploom models. The phases are preliminary research, development and assessment. The instruments used in data collection that includes pieces of observation/interviews, instrument self-evaluation, instruments validity. The results of the validation expert on student worksheets get a valid result the average value 80,1%. Validity of students worksheet based problem-based learning for 9th grade junior high school in living organism inheritance and food biotechnology get valid category.

Obesity promotes prolonged ovalbumin-induced airway inflammation modulating T helper type 1 (Th1), Th2 and Th17 immune responses in BALB/c mice.

Science.gov (United States)

Silva, F M C; Oliveira, E E; Gouveia, A C C; Brugiolo, A S S; Alves, C C; Correa, J O A; Gameiro, J; Mattes, J; Teixeira, H C; Ferreira, A P

2017-07-01

Clinical and epidemiological studies indicate that obesity affects the development and phenotype of asthma by inducing inflammatory mechanisms in addition to eosinophilic inflammation. The aim of this study was to assess the effect of obesity on allergic airway inflammation and T helper type 2 (Th2) immune responses using an experimental model of asthma in BALB/c mice. Mice fed a high-fat diet (HFD) for 10 weeks were sensitized and challenged with ovalbumin (OVA), and analyses were performed at 24 and 48 h after the last OVA challenge. Obesity induced an increase of inducible nitric oxide synthase (iNOS)-expressing macrophages and neutrophils which peaked at 48 h after the last OVA challenge, and was associated with higher levels of interleukin (IL)-4, IL-9, IL-17A, leptin and interferon (IFN)-γ in the lungs. Higher goblet cell hyperplasia was associated with elevated mast cell influx into the lungs and trachea in the obese allergic mice. In contrast, early eosinophil influx and lower levels of IL-25, thymic stromal lymphopoietin (TSLP), CCL11 and OVA-specific immunoglobulin (IgE) were observed in the obese allergic mice in comparison to non-obese allergic mice. Moreover, obese mice showed higher numbers of mast cells regardless of OVA challenge. These results indicate that obesity affects allergic airway inflammation through mechanisms involving mast cell influx and the release of TSLP and IL-25, which favoured a delayed immune response with an exacerbated Th1, Th2 and Th17 profile. In this scenario, an intense mixed inflammatory granulocyte influx, classically activated macrophage accumulation and intense mucus production may contribute to a refractory therapeutic response and exacerbate asthma severity. © 2017 British Society for Immunology.

The Balance of Th1/Th2 and LAP+Tregs/Th17 Cells Is Crucial for Graft Survival in Allogeneic Corneal Transplantation

Directory of Open Access Journals (Sweden)

Shang Li

2018-01-01

Full Text Available Purpose. CD4+LAP+ T cells are newly discovered regulatory T cells (Tregs. The aim of this study is to investigate the balance of Th1/Th2 and LAP+Tregs/Th17 in mice after allogeneic corneal transplantation. Methods. A total of 65 mice received orthotopic penetrating transplantation. According to the survival scores of the grafts, the mice were divided into the rejection group and the survival group 3 weeks after transplantation. Th1, Th2, Th17, and regulatory T cells in the ipsilateral drainage lymph nodes and spleens were measured with flow cytometry. The related cytokines in aqueous humor were also analyzed. Results. The frequencies of Foxp3+Tregs, GARP+Tregs, and LAP+Tregs in the survival group were significantly higher than those in the rejection group. And the expression trend of CD4+LAP+ T cells and CD4+GARP+ T cells was consistent. The level of IFN-γ, TNF, IL-6, and IL-17A markedly increased in aqueous humor during corneal allograft rejection. The ratio of Th1/Th2 and Th17/LAP+Tregs significantly increased in the rejection group at the 3rd week after corneal transplantation. Conclusion. LAP+Tregs might be regarded as substitute for Foxp3+Tregs. The balance of Th1/Th2 and LAP+Tregs/Th17 is crucial for corneal allograft survival.

L’intérêt historiographique des manuscrits de travail de linguistes : l’exemple de la linguistique générale de Joseph Vendryes

Directory of Open Access Journals (Sweden)

Testenoire Pierre-Yves

2016-01-01

Full Text Available Dans quelle mesure les manuscrits de travail des linguistes présentent-ils un intérêt pour les historiens de la linguistique ? Ce type de documents suscite, depuis quelques années, un regain indéniable de curiosité. L’exploration d’un nombre croissant de fonds d’archives de savants permet, au-delà d’un élargissement de l’horizon documentaire, d’envisager des approches comparatives entre différentes pratiques savantes. Elle ouvre aussi de nouvelles interrogations. Cet article réfléchit à l’intérêt historiographique de ce type de documents à partir d’un cas inédit : les papiers de travail consacrés à la linguistique générale du linguiste français, Joseph Vendryes (1875-1960. On met en évidence le double intérêt des archives privées de savants : documentaire et processuel. On aborde, dans un premier temps, les manuscrits d’un point de vue documentaire de façon à dégager ce que leur prise en compte modifie de notre connaissance de la linguistique générale de Joseph Vendryes. Le deuxième temps, consacré à la perspective processuelle, fait des manuscrits le lieu de l’observation de la méthode. Il s’agit d’analyser, à partir des manuscrits préparatoires à l’écriture d’un article, comment s’élabore un discours scientifique à caractère général sur le langage et les langues. Ces archives privées sont au carrefour de questionnements de recherche qui relèvent aussi bien d’une histoire conceptuelle que d’une histoire sociale des sciences du langage.

spv locus aggravates Salmonella infection of zebrafish adult by inducing Th1/Th2 shift to Th2 polarization.

Science.gov (United States)

Wu, Shu-Yan; Wang, Li-Dan; Xu, Guang-Mei; Yang, Si-di; Deng, Qi-Feng; Li, Yuan-Yuan; Huang, Rui

2017-08-01

Salmonella enterica serovar typhimurium (S. typhimurium) are facultative intracellular enteric pathogens causing disease with a broad range of hosts. It was known that Th1-type cytokines such as IFN-γ, IL-12, and TNF-α etc. could induce protective immunity against intracellular pathogens, while Th2-type cytokines such as IL-4, IL-10, and IL-13 etc. are proved to help pathogens survive inside hosts and cause severe infection. One of the critical virulence factor attributes to the pathogenesis of S. typhimurium is Salmonella plasmid virulence genes (spv). Until now, the interaction between spv locus and the predictable generation of Th1 or Th2 immune responses to Salmonella has not been identified. In this study, zebrafish adults were employed to explore the effect of spv locus on Salmonella pathogenesis as well as host adaptive immune responses especially shift of Th1/Th2 balance. The pathological changes of intestines and livers in zebrafish were observed by hematoxylin-eosin (HE) staining and electron microscopy. Levels of the transcription factors of Th1 (Tbx21) and Th2 (GATA3) were measured by real-time quantitative PCR (RT-qPCR). Expression of cytokines were determined by using RT-qPCR and ELISA, respectively. Results showed that spv operon aggravates damage of zebrafish. Furthermore, it demonstrated that spv locus could inhibit the transcription of tbx21 gene and suppress the expression of cytokines IFN-γ, IL-12 and TNF-α. On the contrary, the transcription of gata3 gene could be promoted and the expression of cytokines IL-4, IL-10 and IL-13 were enhanced by spv locus. Taken together, our data revealed that spv locus could aggravate Salmonella infection of zebrafish adult by inducing an imbalance of Th1/Th2 immune response and resulting in a detrimental Th2 bias of host. Copyright © 2017. Published by Elsevier Ltd.

Simulation of the Thermal Response of Externally Cooled Ordnance Engulfed in Large Aviation Fuel Fires

Science.gov (United States)

1990-09-01

400j.GE T (Io 1Q0 .(MELT ViH N- T ?A( 11 3 7( 2,( 1 TBEFORE AVG TEMP(OF) L] SIDE INTERFACE TE.M1P CALCULATE THERMAL CONDUCTIVITY CALCULATION | L... ISTE a AVG TEMP EXPLOSIVE SIDE OF INTERFACE AE-0 SLIU INT 00726 ENERGY GENERATED IS. (INT).LT. T •ELT(EXPL) T 0 EI"E’rNG I CALCULATE NEWl TEMP WIlTH

PREFACE: EUCAS '09: The 9th European Conference on Applied Superconductivity (Dresden, Germany, 13-17 September 2009) EUCAS '09: The 9th European Conference on Applied Superconductivity (Dresden, Germany, 13-17 September 2009)

Science.gov (United States)

Holzapfel, Bernhard; Schultz, Ludwig; Schlörb, Heike

2010-03-01

During the 9th European Conference on Applied Superconductivity, 6 plenary, 22 invited, 206 oral and 429 poster contributions were presented on recent developments in the field of applied superconductivity. This issue of Superconductor Science and Technology contains plenary, invited and a selection of contributed oral papers of the four main EUCAS areas: materials, wires and tapes, large scale applications and electronics. The remaining contributed papers that were selected for the conference proceedings will be published in the Journal of Physics: Conference Series. The Dresden EUCAS conference, with 712 participants from 43 countries, continued the tradition of preceding EUCAS conferences of combining basic superconductivity research contributions with the discussion of recent material advances and new developments in large scale and electronic applications. In Dresden, contributions on the recently discovered Fe-based superconductors were presented for the first time during a EUCAS conference and their potential for applications was intensively discussed. Among all the high level papers of this issue we particularly want to highlight the plenary contribution of Praveen Chaudhari on grain boundaries in cuprate superconductors. In his paper Praveen discusses the Jc limitation in HTSC tapes and tunnelling spectroscopy in LSCO thin film bicrystals. Just a few weeks ago we received the sad news that Praveen had passed away on 13 January 2010. Already fighting with his serious illness, Praveen spent all his efforts last fall finishing his plenary talk and paper. This paper will remind us always of his contributions to basic and applied aspects of superconductivity in general and especially his important work on HTSC grain boundaries. Finally we want to acknowledge the help of the International Advisory and National Committees in setting up the scientific program and we would especially like to express our gratitude to all the members of the Local Organization

Transcription of Toll-Like Receptors 2, 3, 4 and 9, FoxP3 and Th17 Cytokines in a Susceptible Experimental Model of Canine Leishmania infantum Infection

Science.gov (United States)

Hosein, Shazia; Rodríguez-Cortés, Alhelí; Blake, Damer P.; Allenspach, Karin; Alberola, Jordi; Solano-Gallego, Laia

2015-01-01

Canine leishmaniosis (CanL) due to Leishmania infantum is a chronic zoonotic systemic disease resulting from complex interactions between protozoa and the canine immune system. Toll-like receptors (TLRs) are essential components of the innate immune system and facilitate the early detection of many infections. However, the role of TLRs in CanL remains unknown and information describing TLR transcription during infection is extremely scarce. The aim of this research project was to investigate the impact of L. infantum infection on canine TLR transcription using a susceptible model. The objectives of this study were to evaluate transcription of TLRs 2, 3, 4 and 9 by means of quantitative reverse transcription polymerase chain reaction (qRT-PCR) in skin, spleen, lymph node and liver in the presence or absence of experimental L. infantum infection in Beagle dogs. These findings were compared with clinical and serological data, parasite densities in infected tissues and transcription of IL-17, IL-22 and FoxP3 in different tissues in non-infected dogs (n = 10), and at six months (n = 24) and 15 months (n = 7) post infection. Results revealed significant down regulation of transcription with disease progression in lymph node samples for TLR3, TLR4, TLR9, IL-17, IL-22 and FoxP3. In spleen samples, significant down regulation of transcription was seen in TLR4 and IL-22 when both infected groups were compared with controls. In liver samples, down regulation of transcription was evident with disease progression for IL-22. In the skin, upregulation was seen only for TLR9 and FoxP3 in the early stages of infection. Subtle changes or down regulation in TLR transcription, Th17 cytokines and FoxP3 are indicative of the silent establishment of infection that Leishmania is renowned for. These observations provide new insights about TLR transcription, Th17 cytokines and Foxp3 in the liver, spleen, lymph node and skin in CanL and highlight possible markers of disease susceptibility in

Thermal expansion studies on Th(MoO4)2, Na2Th(MoO4)3 and Na4Th(MoO4)4

International Nuclear Information System (INIS)

Keskar, Meera; Krishnan, K.; Dahale, N.D.

2008-01-01

Thermal expansion behavior of Th(MoO 4 ) 2 , Na 2 Th(MoO 4 ) 3 and Na 4 Th(MoO 4 ) 4 was studied under vacuum in the temperature range of 298-1123 K by high temperature X-ray diffractometer. Th(MoO 4 ) 2 was synthesized by reacting ThO 2 with 2 mol of MoO 3 , at 1073 K in air and Na 2 Th(MoO 4 ) 3 and Na 4 Th(MoO 4 ) 4 were prepared by reacting Th(MoO 4 ) 2 with 1 and 2 mol of Na 2 MoO 4 , respectively at 873 K in air. The XRD data of Th(MoO 4 ) 2 was indexed on orthorhombic system where as XRD data of Na 2 Th(MoO 4 ) 3 and Na 4 Th(MoO 4 ) 4 were indexed on tetragonal system. The lattice parameters and cell volume of all the three compounds, fit into polynomial expression with respect to temperature, showed positive thermal expansion (PTE) up to 1123 K. The average value of thermal expansion coefficients for Th(MoO 4 ) 2 , Na 2 Th(MoO 4 ) 3 and Na 4 Th(MoO 4 ) 4 were determined from the high temperature data

Monazite processing of tin mining waste : rare earth separation from U and Th

International Nuclear Information System (INIS)

Hafni, L.N.; Faizal, R.; Sugeng, W.; Budi, S.; Arif, S.; Susilaningtyas

2000-01-01

Separation of Rare Earths from U and Th of Bangka monazite digestion solution, by using NaOH reagent and precipitation system has been carried out. The aim of the experiment is to find a condition of RE(OH) sub.3 precipitation to produce maximal RE recovery and high purity of RE that are free from radioelements U and Th. Parameters studied were pH, NaOH normality and precipitation time. The optimal conditions obtained were pH 9.8, 1N NaOH and 3 hours precipitation time. At this condition recovery of the RE(OH) sub.3 is 99.79 % and Th 4.52 %. However uranium and phosphate were not detected. Purity of the products are RE(OH) sub.3 98.868 %, Th(OH) sub.4 0.009 % and the others 1.123 %. (author)

Adjuvant therapy for gastric cancer: what have we learned since INT0116?

Science.gov (United States)

Jácome, Alexandre A; Sankarankutty, Ajith K; dos Santos, José Sebastião

2015-04-07

Gastric cancer is one of the main cancer-related causes of death worldwide. The curative treatment of gastric cancer consists of tumor resection and lymphadenectomy. However, surgical treatment alone is associated with high recurrence rates. Adjuvant treatment strategies have been studied over the last decades, but there have been controversial results from the initial studies. The pivotal INT0116 study demonstrated that the use of adjuvant chemoradiotherapy with 5-fluorouracil increases relapse-free and overall survival, and it has been adopted across the Western world. The high toxicity of radiochemotherapy and suboptimal surgical treatment employed, with fewer than 10% of the patients submitted to D2 lymphadenectomy, were the main study limitations. Since its publication, other adjuvant treatment modalities have been studied, and radiochemotherapy is being refined to improve its efficacy and safety. A multimodal approach has been demonstrated to significantly increase relapse-free and overall survival, and it can be offered in the form of perioperative chemotherapy, adjuvant chemoradiotherapy or adjuvant chemotherapy, regardless of the extent of lymphadenectomy. The objective of the present review is to report the major advances obtained in the last decades in the adjuvant treatment of gastric cancer as well as the perspectives of treatment based on recent knowledge of the molecular biology of the disease.

Justifier l’injustifiable : fonder l’inégalité sexuelle dans la République.

Directory of Open Access Journals (Sweden)

Sandrine Lévêque

2009-03-01

Full Text Available La question de l’accès des femmes à l’espace public au sens général du terme fait aujourd’hui l’objet d’un intérêt renouvelé dans le champ académique. Après plusieurs thèses de grande qualité sur ce sujet, 1 des livres, parfois issus de ces thèses (cf. Lépinard, 2007, commencent à intéresser les éditeurs. Il semble ainsi qu’un sujet jusqu’alors réservé à un lectorat savant et généralement féminin puisse désormais toucher un public élargi. Le livre de ...

Academic stress-induced changes in Th1- and Th2-cytokine response

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Areej M. Assaf

2017-12-01

Full Text Available Psychological stress stimulates physiological responses releasing catecholamines and corticoids, which act via corresponding receptors on immune cells, producing a shift in the cytokine balance. These responses are variable depending on the nature of stressors. The effect of the academic stress on the production of the Th1-cytokines (TNF-α, IFN-γ, IL-1β, IL-2, IL-6 and IL-8 and Th2-cytokines (IL-1ra, IL-4, IL-5 and IL-10 on 35 medical/health sciences students after completing their questionnaires was investigated. Blood samples were taken at three stages; baseline stage at the beginning, midterm and final academic examination stages. Plasma cortisol and cytokines were measured during the three stages. The last two stages were compared with the baseline non-stress period. Results of the stress induced during the final examination stage were the highest with a significant increase in cortisol release, IL-4, IL-5 and IL-1ra release with a shift in Th1:Th2 cytokines balance towards Th2. Whereby, the midterm stage did not show significant reduction in Th1-cytokines except for TNF-α, with an increase in IFN-γ level that was reduced in the third stage. Th2 cytokine, IL-1ra, had positive correlations with Th1 cytokines; IL-2 and IFN-γ in the second stage and IL-6 cytokine in the third stage. Cortisol was positively correlated with IL-8 in the last stage and heart rates had negative correlation with IL-10 in the first and last stages. Findings of this study indicate that exam stress down-regulates Th1 with a selective up-regulation of Th2-cytokines. In conclusion, Cortisol might have a role in suppressing the release of Th1- mediated cellular immune response which could increase the vulnerability among the students to infectious diseases.

Academic stress-induced changes in Th1- and Th2-cytokine response.

Science.gov (United States)

Assaf, Areej M; Al-Abbassi, Reem; Al-Binni, Maysaa

2017-12-01

Psychological stress stimulates physiological responses releasing catecholamines and corticoids, which act via corresponding receptors on immune cells, producing a shift in the cytokine balance. These responses are variable depending on the nature of stressors. The effect of the academic stress on the production of the Th1-cytokines (TNF-α, IFN-γ, IL-1β, IL-2, IL-6 and IL-8) and Th2-cytokines (IL-1ra, IL-4, IL-5 and IL-10) on 35 medical/health sciences students after completing their questionnaires was investigated. Blood samples were taken at three stages; baseline stage at the beginning, midterm and final academic examination stages. Plasma cortisol and cytokines were measured during the three stages. The last two stages were compared with the baseline non-stress period. Results of the stress induced during the final examination stage were the highest with a significant increase in cortisol release, IL-4, IL-5 and IL-1ra release with a shift in Th1:Th2 cytokines balance towards Th2. Whereby, the midterm stage did not show significant reduction in Th1-cytokines except for TNF-α, with an increase in IFN-γ level that was reduced in the third stage. Th2 cytokine, IL-1ra, had positive correlations with Th1 cytokines; IL-2 and IFN-γ in the second stage and IL-6 cytokine in the third stage. Cortisol was positively correlated with IL-8 in the last stage and heart rates had negative correlation with IL-10 in the first and last stages. Findings of this study indicate that exam stress down-regulates Th1 with a selective up-regulation of Th2-cytokines. In conclusion, Cortisol might have a role in suppressing the release of Th1- mediated cellular immune response which could increase the vulnerability among the students to infectious diseases.

Pentagon 9/11

Science.gov (United States)

2007-09-01

rooms. On the 4th Floor above the aircraft entry hole, when smoke and heat dis- oriented one of the troopers, Officers Donald Behe and Abraham Diaz ...11 September 2001. 4. Interv Jester, 19 Oct 01, 20; ibid, 31 Jan 06, 2; Alicia Borlik, "DoD Drill Tests Response to Terrorist Attack:’ 9Jun 98, AFPS...Behe, Diaz , and Mapp citations, OSD Hist. For rescue accounts by two Virginia state troopers see memos Trooper Myrlin Wimbish for 1st Sgt Richard S

Collection and evaluation of nuclear data of Th-232

International Nuclear Information System (INIS)

Osawa, Takaaki

1979-01-01

Present status of the requirement to and measurement and evaluation of the nuclear data of Th-232 is presented. The accuracy and energy range of the observed data at present are not enough to the demand from reactor engineering. The data of total cross-section are given in the energy range from 1.5 to 15 MeV from the data by Foster and Fasoli. The data by Uttley for the energy less than 1.5 MeV were accepted. Recently, Whalen and Kobayashi presented new data. Optical potential parameters were deduced. Re-normalization of the capture cross-sections of Th-232 was made on the basis of the evaluated values by Matsunobu and by Kanda. The values are a little smaller than the values in ENDF/B-4. Fission cross-sections were given by Henkel up to 9 MeV, and by Rago and Pankratov for the energy range above 9 MeV. Recently, Behrens presented new data for wide energy range. The accuracy of the measured cross-sections of inelastic scattering is not enough for reactor design. The accurate values of the cross-sections of (n, 2n) reaction of Th-232 have been demanded. Resonance parameters have been measured for wide energy range. In the energy range of thermal neutrons, the capture cross-section is about 7.4 barn. The characteristics of velocity dependence of the capture cross-section in this range should be investigated. (Kato, T.)

The role of data in scientific progress

International Nuclear Information System (INIS)

Glaeser, P.S.

1985-01-01

This book contains 109 papers presented at the 9th Int. CODATA Conference and illustrates two main themes (1) new computer-based methods for storing, manipulating and disseminating scientific and technical data, and (2) the use of such computerized data files to give new scientific insights. The broad range of scientific disciplines covered includes geology and geochemistry, oceanography and ecology, molecular biology and biotechnology, chemical engineering, materials properties, energy systems, data base design and management - theory and practice, and finally, a last section on data retrieval and library systems. 12 items are included in Atomindex separately. (Auth.)

Analysis Components Investigation Report

Science.gov (United States)

2014-10-01

integration n (1.4.1) t r to integra Solr separa nstrate the resco. Ther e file system f 22 ATION context, ocument software ased on visualize d offers...query. NLTK8 libr uments. Th locations, b neral Ling rdNet9 is a ts of spee tionships. aning of a w approach rdnet sema ween two w ilar words...Te The this doc The nam inte Mo sea exa this gro .2.4 Do A m que lea An Fea que If w wh libr out Vow Mic nam com 2 http://zinko s Investigation MENT

Métaphores, paraboles et analogie: La référence à la théologie dans la pensée de Paul Ricœur

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Gilbert Vincent

2012-12-01

Full Text Available Il est admis que l’étude de la métaphore représente une inflexion décisive dans l’herméneutique de Ricœur. On sait peut-être moins que cette étude est concomitante de celle de la parabole, qui représente une inflexion également notable dans la contribution ricœurienne à l’herméneutique biblique. Il arrive pourtant qu’on tire argument de cette concomitance pour prétendre que le transfert de certains présupposés théologiques (quant à la nature du langage et de la Vérité s’en trouve facilité, et l’on ne craint pas d’avancer que les pages consacrées à l’analogia entis, dans La métaphore vive, prouvent la prégnance d’intérêts théologiques douteux dans l’élaboration de la théorie de la métaphore. Pour contrer cette critique dévastatrice, nous nous appuierons sur certaines analyses d’Umberto Eco, qui impliquent que la question des rapports entre analogia entis et métaphore n’a rien d’épistémologiquement scandaleux, et sur celles d’Alain qui, voici un siècle, a esquissé une interprétation des paraboles très proche de celle de Ricœur.

Asymmetrically deformed third minimum in the 231Th and 233Th fission barriers

International Nuclear Information System (INIS)

Blons, J.; Mazur, C.; Paya, D.; Ribrag, M.; Weigmann, H.

1981-01-01

Neutron induced fission cross-sections of 230 Th and 232 Th have been measured up to 5 MeV. The electron linear accelerator (GELINA) has been used as a neutron time of flight spectrometer with a nominal resolution of 84 psec/m for 230 Th(n,f) and 42 psec/m for 232 Th(n,f) reaction. The fission fragment detector was a 6 cell gas scintillator filled with xenon. The existence of fine structure peaks, a few keV wide, in both the 230 Th(n,f) and 232 Th(n,f) cross sections, is definitively confirmed. The analysis of the two vibrational resonances located respectively at 720 keV for 230 Th(the figure) and 1.6 MeV for 232 Th, shows clearly that these peaks can be interpreted, in terms of two rotational bands with opposite parities. This parity degeneracy is a consequence of the asymmetric, pear-like deformation of the excited nucleus [ru

IL-33 induces IL-9 production in human CD4⁺ T cells and basophils

DEFF Research Database (Denmark)

Blom, Lars; Poulsen, Britta Cathrina; Jensen, Bettina M.

2011-01-01

blood. TGF-β has been described as a critical factor for IL-9 induction in Th2 cells; however, we found that TGF-β also induces co-production of IL-9 in purified, naïve (>99%) CD4(+)CD45RA(+)CD45RO(-)CD25(-) T cells differentiated towards a Th1 profile. Subsequently, it was demonstrated that TGF...

Heterogeneous transgene expression in the retinas of the TH-RFP, TH-Cre, TH-BAC-Cre and DAT-Cre mouse lines.

Science.gov (United States)

Vuong, H E; Pérez de Sevilla Müller, L; Hardi, C N; McMahon, D G; Brecha, N C

2015-10-29

Transgenic mouse lines are essential tools for understanding the connectivity, physiology and function of neuronal circuits, including those in the retina. This report compares transgene expression in the retina of a tyrosine hydroxylase (TH)-red fluorescent protein (RFP) mouse line with three catecholamine-related Cre recombinase mouse lines [TH-bacterial artificial chromosome (BAC)-, TH-, and dopamine transporter (DAT)-Cre] that were crossed with a ROSA26-tdTomato reporter line. Retinas were evaluated and immunostained with commonly used antibodies including those directed to TH, GABA and glycine to characterize the RFP or tdTomato fluorescent-labeled amacrine cells, and an antibody directed to RNA-binding protein with multiple splicing to identify ganglion cells. In TH-RFP retinas, types 1 and 2 dopamine (DA) amacrine cells were identified by their characteristic cellular morphology and type 1 DA cells by their expression of TH immunoreactivity. In the TH-BAC-, TH-, and DAT-tdTomato retinas, less than 1%, ∼ 6%, and 0%, respectively, of the fluorescent cells were the expected type 1 DA amacrine cells. Instead, in the TH-BAC-tdTomato retinas, fluorescently labeled AII amacrine cells were predominant, with some medium diameter ganglion cells. In TH-tdTomato retinas, fluorescence was in multiple neurochemical amacrine cell types, including four types of polyaxonal amacrine cells. In DAT-tdTomato retinas, fluorescence was in GABA immunoreactive amacrine cells, including two types of bistratified and two types of monostratified amacrine cells. Although each of the Cre lines was generated with the intent to specifically label DA cells, our findings show a cellular diversity in Cre expression in the adult retina and indicate the importance of careful characterization of transgene labeling patterns. These mouse lines with their distinctive cellular labeling patterns will be useful tools for future studies of retinal function and visual processing. Published by Elsevier

Oxidative stress modulates the cytokine response of differentiated Th17 and Th1 cells.

Science.gov (United States)

Abimannan, Thiruvaimozhi; Peroumal, Doureradjou; Parida, Jyoti R; Barik, Prakash K; Padhan, Prasanta; Devadas, Satish

2016-10-01

Reactive oxygen species (ROS) signaling is critical in T helper (Th) cell differentiation; however its role in differentiated Th cell functions is unclear. In this study, we investigated the role of oxidative stress on the effector functions of in vitro differentiated mouse Th17 and Th1 cells or CD4 + T cells from patients with Rheumatoid Arthritis using pro-oxidants plumbagin (PB) and hydrogen peroxide. We found that in mouse Th cells, non-toxic concentration of pro-oxidants inhibited reactivation induced expression of IL-17A in Th17 and IFN-γ in Th1 cells by reducing the expression of their respective TFs, RORγt and T-bet. Interestingly, in both the subsets, PB increased the expression of IL-4 by enhancing reactivation induced ERK1/2 phosphorylation. We further investigated the cytokine modulatory effect of PB on CD4 + T cells isolated from PBMCs of patients with Rheumatoid Arthritis, a well-known Th17 and or Th1 mediated disease. In human CD4 + T cells from Rheumatoid Arthritis patients, PB reduced the frequencies of IL-17A + (Th17), IFN - γ + (Th1) and IL-17A + /IFN - γ + (Th17/1) cells and also inhibited the production of pro-inflammatory cytokines TNF-α and IL-6. N-Acetyl Cysteine (NAC) an antioxidant completely reversed PB mediated cytokine modulatory effects in both mouse and human cells indicating a direct role for ROS. Together our data suggest that oxidative microenvironment can alter cytokine response of terminally differentiated cells and thus altering intracellular ROS could be a potential way to target Th17 and Th1 cells in autoimmune disorders. Copyright © 2016. Published by Elsevier Inc.

STECH,4(1), S/NO 9, FEBRUARY, 2015

African Journals Online (AJOL)

ZTE

2015-02-09

Feb 9, 2015 ... It is recommended that the current interaction between mathematics ... As evidenced by the discoveries of the last half of the 20th .... medicine, banking, finance, actual science, architecture, fine and industrial arts etc could get ...

Intrinsic atopic dermatitis (AD) shows similar Th2 and higher Th17 immune activation compared to extrinsic AD

Science.gov (United States)

Suárez-Fariñas, M; Dhingra, N; Gittler, J; Shemer, A; Cardinale, I; de Guzman Strong, C; Krueger, JG; Guttman-Yassky, E

2013-01-01

Background Atopic dermatitis (AD) is classified as extrinsic (ADe) and intrinsic (ADi), representing approximately 80% and 20% of patients, respectively. While sharing a similar clinical phenotype, only ADe is characterized by high serum IgE. Since most AD patients exhibit high IgE, an “allergic”/IgE-mediated disease pathogenesis was hypothesized. However, current models associate AD with T-cell activation, particularly Th2/Th22 polarization, and epidermal barrier defects. Objective To define if both variants share a common pathogenesis. Methods We stratified 51 severe AD patients as ADe (42) and ADi (9) (with similar mean disease activity/SCORAD), and analyzed the molecular and cellular skin pathology of lesional and non-lesional ADi and ADe using gene-expression (RT-PCR) and immunohistochemistry. Results A significant correlation between IgE levels and SCORAD (r=0.76, pextrinsic and intrinsic AD variants might be treated with T-cell targeted therapeutics or agents that modify keratinocyte responses. PMID:23777851

9th Annual CMMI Technology Conference and User Group-Tuesday

Science.gov (United States)

2009-11-19

ISO /IEC 27001 ISO /IEC 20000 DAILY RELEASE INTERATION Concept Deployment Close Out Close Out Planning Planning Design Develop Testing Analysis User...River Track 7 Wind Star 8:00 am - 9:45 am Session A 1A1 - Tutorial 9377 - CMMI®, ISO , Six Sigma and ANSI 748: Soulmates that Should to be...Session B 1B1 - Tutorial 9377 - CMMI®, ISO , Six Sigma and ANSI 748: Soulmates that Should to be Together – Quite Easily! Ms. Nishi

Predição da composição corporal e da carcaça a partir da seção entre a 9ª e 11ª costelas em bovinos Nelore Predicting body and carcass composition using the section between 9th and 11th ribs in Nellore cattle

Directory of Open Access Journals (Sweden)

Marcos Inácio Marcondes

2009-08-01

trial all the animals were slaughtered to determine the empty body weight and physical and chemical body composition using the right carcass half. From left carcass half one sample from 9th to 11th ribs (HH section was obtained. The HH section did not estimate well the physical carcass composition. The Paulino equation was efficient in estimating the Ca concentration in the empty body weight. New equations were proposed for all the macrominerals to estimate their contents in empty body weight using the HH section. It was concluded that the Hankins and Howe equations did not correctly estimate the carcass physical composition in Nellore cattle, and that the macromineral composition can be estimated using the HH section in Nellore cattle.

Contamination of the Th II line and the age of the Galaxy

International Nuclear Information System (INIS)

Lawler, J.E.; Whaling, W.; Grevesse, N.

1990-01-01

The age of the Galaxy may be estimated from observations of the ratio of stellar abundances of thorium, which has only one long-lived isotope with a half-life comparable to the suspected age of the Galaxy, and neodymium, a stable element. The Th/Nd abundance ratio in a sample of G-dwarf stars of different ages was derived from the intensities of one Th II and one Nd II absorption line, and indicated a rather young galactic age of 9.6 Gyr. But the Th II line is blended with a Co I line. Here we determine the transition probability of the Co I line by combining radiative lifetime and branching-ratio measurements. We show that the Co I contribution cannot be neglected in deriving Th/Nd ratios. By comparing our results with predictions based on models of galactic chemical evolution, we suggest a revised age of the Galaxy of 15-20 Gyr. (author)

L'intégration des TIC dans un environnement éducatif conditionné par le système du 'spoon-feeding.'

OpenAIRE

Saurty , Krishnah Moortee

2013-01-01

Cet article prend son essence dans un projet pédagogique dont la préoccupation est de renforcer les savoirs notamment à travers le concept d'apprentissage intégrant les Technologies de l'Information et de la Communication (Tic) afin de développer des actions éducatives pouvant apporter des réponses réelles aux principes du 'spoon-feeding', véritable pilier du système éducatif mauricien s'appuyant sur le contenu du savoir disciplinaire et conditionnant l'apprenant dans sa capacité à développer...

My Son The Fanatic, de Hanif Kureishi, ou l’intégration à rebours

Directory of Open Access Journals (Sweden)

Jean-Paul Revauger

2007-11-01

Full Text Available Utiliser un film, ou toute création culturelle, pour comprendre le social pose un certain nombre de problèmes méthodologiques. Un film n’est pas un « reflet ». Une création, même si elle se place sous le sceau du réalisme, a un rapport très fort mais indirect avec le contexte historique de sa genèse. Elle est le produit de la rencontre d’un contexte, d’un créateur doté d’une idéologie, d’un « habitus », d’un corpus de valeurs, des modes et techniques en vigueur dans le champ de la création au moment de celle-ci et, comme le rappelle Bourdieu, de la stratégie du créateur par rapport à ses collègues/concurrents. Enfin, sans ajouter une note discordante supplémentaire aux théories de la réception, l’œuvre sera perçue de façon différente selon les publics. My Son the Fanatic sera donc perçu comme une œuvre satanique par les fondamentalistes musulmans, mais sans doute aussi chrétiens, comme une bluette charmante par les midinettes au grand cœur qui semblent être le public visé par la présentation publicitaire du film, comme une démonstration de la justesse de leurs thèses par les partisans de l’intégration, mais aussi par les émules de Huntington pour qui le choc des civilisations est inéluctable, enfin comme une manifestation irresponsable d’ « islamophobie » par les nostalgiques des politiques multiculturalistes d’antan. Les aficionados de Hanif Kureishi, auteur de la nouvelle sur laquelle le film est fondé, et scénariste du film lui-même, y retrouveront le plaidoyer pour la liberté individuelle et, en particulier, la liberté sexuelle qu’ils attendent, mais seront un peu surpris par les côtés didactiques, pour employer cet adjectif dans une acception qui déplait aux didacticiens, c'est-à-dire une volonté de démonstration un peu insistante.Using films, or, for that matter, any cultural artefact in order to reach an understanding of social issues raises a number of

The fission cross sections of 230Th, 232Th, 233U, 234U, 236U, 238U, 237Np, 239Pu and 242Pu relative 235U at 14.74 MeV neutron energy

International Nuclear Information System (INIS)

Meadows, J.W.

1986-12-01

The measurement of the fission cross section ratios of nine isotopes relative to 235 U at an average neutron energy of 14.74 MeV is described with particular attention to the determination of corrections and to sources of error. The results are compared to ENDF/B-V and to other measurements of the past decade. The ratio of the neutron induced fission cross section for these isotopes to the fission cross section for 235 U are: 230 Th - 0.290 +- 1.9%; 232 Th - 0.191 +- 1.9%; 233 U - 1.132 +- 0.7%; 234 U - 0.998 +- 1.0%; 236 U - 0.791 +- 1.1%; 238 U - 0.587 +- 1.1%; 237 Np - 1.060 +- 1.4%; 239 Pu - 1.152 +- 1.1%; 242 Pu - 0.967 +- 1.0%. 40 refs., 11 tabs., 9 figs

Modulation of chicken macrophage effector function by Th1/Th2 cytokines

Science.gov (United States)

Regulation of macrophage activity by TH1/2 cytokines is important to maintain the balance of immunity to provide adequate protective immunity while avoiding excessive inflammation. IFN-gamma and IL-4 are the hallmark TH1 and TH2 cytokines, respectively. In avian species, information concerning reg...

Interleukin 9 and its receptor: an overview of structure and function.

Science.gov (United States)

Demoulin, J B; Renauld, J C

1998-01-01

Interleukin-9 (IL-9) is a multifunctional cytokine produced by activated TH2 clones in vitro and during TH2-like T cell responses in vivo. Although IL-9 was initially described as a T cell growth factor, its role in T cell responses is still unclear. While freshly isolated normal T cells do not respond to IL-9, this cytokine induces the proliferation of murine T cell lymphomas in vitro, and in vivo overexpression of IL-9 results in the development of thymic lymphomas. In the human, the existence of an IL-9 mediated autocrine loop has been suggested for some malignancies such as Hodgkin's disease. Various observations indicate that IL-9 is actively involved in mast cells responses by inducing the proliferation and differentiation of these cells. Other potential biological targets for IL-9 include B lymphocytes, and hematopoietic progenitors, for which higher responses were observed with foetal or transformed cells as compared to normal adult progenitors. The IL-9 receptor is a member of the hemopoietin receptor superfamily and interacts with the gamma chain of the IL-2 receptor for signaling. Signal transduction studies have stressed the role of the Jak-STAT pathway in various IL-9 bioactivities, whereas the 4PS/IRS2 adaptor protein might also play a significant role in IL-9 signaling.

9-Cis retinoic acid protects against methamphetamine-induced neurotoxicity in nigrostriatal dopamine neurons.

Science.gov (United States)

Reiner, David J; Yu, Seong-Jin; Shen, Hui; He, Yi; Bae, Eunkyung; Wang, Yun

2014-04-01

Methamphetamine (MA) is a drug of abuse as well as a dopaminergic neurotoxin. 9-Cis retinoic acid (9cRA), a biologically active derivative of vitamin A, has protective effects against damage caused by H(2)O(2) and oxygen-glucose deprivation in vitro as well as infarction and terminal deoxynucleotidyl transferase-mediated dNTP nick-end labeling (TUNEL) labeling in ischemic brain. The purpose of this study was to examine if there was a protective role for 9cRA against MA toxicity in nigrostriatal dopaminergic neurons. Primary dopaminergic neurons, prepared from rat embryonic ventral mesencephalic tissue, were treated with MA. High doses of MA decreased tyrosine hydroxylase (TH) immunoreactivity while increasing TUNEL labeling. These toxicities were significantly reduced by 9cRA. 9cRA also inhibited the export of Nur77 from nucleus to cytosol, a response that activates apoptosis. The interaction of 9cRA and MA in vivo was next examined in adult rats. 9cRA was delivered intracerebroventricularly; MA was given (5 mg/kg, 4×) one day later. Locomotor behavior was measured 2 days after surgery for a period of 48 h. High doses of MA significantly reduced locomotor activity and TH immunoreactivity in striatum. Administration of 9cRA antagonized these changes. Previous studies have shown that 9cRA can induce bone morphogenetic protein-7 (BMP7) expression and that administration of BMP7 attenuates MA toxicity. We demonstrated that MA treatment significantly reduced BMP7 mRNA expression in nigra. Noggin (a BMP antagonist) antagonized 9cRA-induced behavioral recovery and 9cRA-induced normalization of striatal TH levels. Our data suggest that 9cRA has a protective effect against MA-mediated neurodegeneration in dopaminergic neurons via upregulation of BMP.

Effectiveness of oxfendazole against early and later 4th-stage Strongylus vulgaris in ponies.

Science.gov (United States)

Slocombe, J O; McCraw, B M; Pennock, P; Ducharme, N G; Baird, J D

1986-03-01

Twenty pony foals (reared worm free), 6.5 to 10 weeks of age, were inoculated with Strongylus vulgaris and allocated to 5 groups, each with 4 foals. One week after inoculation, 1 group of 4 foals was given oxfendazole (OFZ) at a dosage rate of 10 mg/kg of body weight, another group was given 2 such treatments 48 hours apart, and a 3rd group was given a placebo. All treatments were administered by stomach tube. Three weeks later, foals were euthanatized and necropsied in a test for efficacy against early 4th-stage larvae. Oxfendazole was 80% and 94.9% effective against early 4th-stage S vulgaris with 1 and 2 doses, respectively. A 4th group of 4 foals was given 2 treatments of OFZ, 48 hours apart, about 8 weeks after inoculation, and a 5th group was given a placebo. These foals were euthanatized and necropsied 5 weeks after treatment in a test for efficacy against later 4th-stage larvae. Two doses of OFZ were 96.6% effective against later 4th-stage larvae.

Essential fats for future health. Proceedings of the 9th Unilever Nutrition Symposium, 26-27 May 2010.

Science.gov (United States)

Calder, P C; Dangour, A D; Diekman, C; Eilander, A; Koletzko, B; Meijer, G W; Mozaffarian, D; Niinikoski, H; Osendarp, S J M; Pietinen, P; Schuit, J; Uauy, R

2010-12-01

The 9th Unilever Nutrition Symposium entitled 'Essential fats for future health', held on 26-27 May 2010, aimed to review the dietary recommendations for essential fatty acids (EFA); discuss the scientific evidence for the roles of EFA in cognition, immune function and cardiovascular health; and to identify opportunities for joint efforts by industry, academia, governmental and non-governmental organizations to effectively improve health behaviour. This paper summarizes the main conclusions of the presentations given at the symposium. Linoleic acid (LA) and α-linolenic acid (ALA) are EFA that cannot by synthesized by the human body. Docosahexaenoic acid (DHA) is considered as conditionally essential because of its limited formation from ALA in the human body and its critical role in early normal retinal and brain development and, jointly with eicosapentaenoic acid (EPA), in prevention of cardiovascular disease (CVD). Some evidence for possible beneficial roles of n-3 fatty acids for immune function and adult cognitive function is emerging. A higher consumption of polyunsaturated fatty acids (PUFA; >10%E), including LA, ALA and at least 250-500 mg per day of EPA+DHA, is recommended for prevention of coronary heart disease (CHD). Two dietary interventions suggest that EFA may affect CVD risk factors in children similarly as in adults. To ensure an adequate EFA intake of the population, including children, public health authorities should develop clear messages based on current science; ensure availability of healthy, palatable foods; and collaborate with scientists, the food industry, schools, hospitals, health-care providers and communities to encourage consumers to make healthy choices.

Down-regulation of Notch signaling pathway reverses the Th1/Th2 imbalance in tuberculosis patients.

Science.gov (United States)

Li, Qifeng; Zhang, Hui; Yu, Liang; Wu, Chao; Luo, Xinhui; Sun, He; Ding, Jianbing

2018-01-01

Th1/Th2 imbalance to Th2 is of significance in the peripheral immune responses in Tuberculosis (TB) development. However, the mechanisms for Th1/Th2 imbalance are still not well determined. Notch signaling pathway is involved in the peripheral T cell activation and effector cell differentiation. However, whether it affects Th1/Th2 imbalance in TB patients is still not known. Here, we used γ-secretase inhibitor (DAPT) to treat the peripheral blood mononuclear cells (PBMCs) from healthy people or individuals with latent or active TB infection in vitro, respectively. Then, the Th1/Th2 ratios were determined by flow cytometry, and cytokines of IFN-γ, IL-4, IL-10 in the culture supernatant were measured by CBA method. The Notch signal pathway associated proteins Hes1, GATA3 and T-bet were quantitated by real-time PCR or immunoblotting. Our results showed that DAPT effectively inhibited the protein level of Hes1. In TB patients, the Th2 ratio increased in the PBMCs, alone with the high expression of GATA3 and IL-4, resulting in the high ratios of Th2/Th1 and GATA3/T-bet in TB patients. However, Th2 cells ratio decreased after blocking the Notch signaling pathway by DAPT and the Th2/Th1 ratio in TB patients were DAPT dose-dependent, accompanied by the decrease of IL-4 and GATA3. But, its influence on Th1 ratio and Th1 related T-bet and IFN-γ levels were not significant. In conclusion, our results suggest that blocking Notch signaling by DAPT could inhibit Th2 responses and restore Th1/Th2 imbalance in TB patients. Copyright © 2017. Published by Elsevier B.V.

Radio properties of type 1.8 and 1.9 Seyfert galaxies

International Nuclear Information System (INIS)

Ulvestad, J.S.

1986-01-01