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Sample records for igpro20 csl bern

  1. Peripatetic Highlights in Bern

    Science.gov (United States)

    Hentschel, Ann M.

    The capital city of the Swiss Canton of Bern and of the Swiss Confederation is nestled in a narrow loop of the Aare river, at the foot of the Alps. The old town, founded around 1191, is well preserved despite a devastating fire in 1405.** Major industries of the region developed under the constraints of modest domestic markets, high transportation costs, and protectionist legislation across national borders. Switzerland thus found its niche in higher-end markets, such as chocolate making, engine building, instruments, fine textiles, and chemicals or pharmaceuticals. My tour past historically significant scientific sites in Bern will use the local legacy of its most illustrious residents, Albert Einstein (1879-1955), who lived there from 1902-1909, and Fritz Houtermans (1903-1966), who lived there from 1952-1966, as its guiding thread through the old town and the university district. Place names in italics mark stops along the tour.

  2. Mobile Seamless Technology Enhanced CSL Oral Communication

    Science.gov (United States)

    Lan, Yu-Ju; Lin, Yen-Ting

    2016-01-01

    The current study aimed at investigating how mobile seamless technology can be used to enhance the pragmatic competence of learners of Chinese as a second language (CSL). 34 overseas CSL learners participated in this study. They were randomly assigned into two groups: the classroom group, executing language tasks in fake contexts in a traditional…

  3. Dissipative Continuous Spontaneous Localization (CSL) model.

    Science.gov (United States)

    Smirne, Andrea; Bassi, Angelo

    2015-08-05

    Collapse models explain the absence of quantum superpositions at the macroscopic scale, while giving practically the same predictions as quantum mechanics for microscopic systems. The Continuous Spontaneous Localization (CSL) model is the most refined and studied among collapse models. A well-known problem of this model, and of similar ones, is the steady and unlimited increase of the energy induced by the collapse noise. Here we present the dissipative version of the CSL model, which guarantees a finite energy during the entire system's evolution, thus making a crucial step toward a realistic energy-conserving collapse model. This is achieved by introducing a non-linear stochastic modification of the Schrödinger equation, which represents the action of a dissipative finite-temperature collapse noise. The possibility to introduce dissipation within collapse models in a consistent way will have relevant impact on the experimental investigations of the CSL model, and therefore also on the testability of the quantum superposition principle.

  4. Automata-Based CSL Model Checking

    DEFF Research Database (Denmark)

    Zhang, Lijun; Jansen, David N.; Nielson, Flemming

    2011-01-01

    For continuous-time Markov chains, the model-checking problem with respect to continuous-time stochastic logic (CSL) has been introduced and shown to be decidable by Aziz, Sanwal, Singhal and Brayton in 1996. The presented decision procedure, however, has exponential complexity. In this paper, we...... probability can then be approximated in polynomial time (using uniformization). This makes the present work the centerpiece of a broadly applicable full CSL model checker. Recently, the decision algorithm by Aziz et al. was shown to be incorrect in general. In fact, it works only for stratified CTMCs...

  5. Furniture firms shuns CSL for EMS program expansion

    Energy Technology Data Exchange (ETDEWEB)

    Deans, B

    1982-05-31

    The R.B. Furniture Company's disappointment in its 10 CSL Industries Inc. energy-management systems is responsible for a decision to install Trimax Controls in the remaining 67 stores. At issue are CSL's service policy of using independent installers and service contractors as well as technical problems with the equipment, although R.B. Furniture concedes it had a 2.5-year payback, a 20% drop in electricity consumption, and generally reliable performance of the CSL system. A CSL official claims its higher equipment costs are the real reason. Interviews with CSL and R.B. Furniture Co. representatives explore the attitudes and problems of both firms. The Trimex system includes a three-year warranty. (DCK)

  6. Emergence of inflationary perturbations in the CSL model

    Energy Technology Data Exchange (ETDEWEB)

    Leon, Gabriel [Universidad de Buenos Aires, Ciudad Universitaria-PabI, Departamento de Fisica, Facultad de Ciencias Exactas y Naturales, Buenos Aires (Argentina); Bengochea, Gabriel R. [Instituto de Astronomia y Fisica del Espacio (IAFE), UBA-CONICET, Buenos Aires (Argentina)

    2016-01-15

    The inflationary paradigm is the most successful model that explains the observed spectrum of primordial perturbations. However, the precise emergence of such inhomogeneities and the quantum-to-classical transition of the perturbations has not yet reached a consensus among the community. The continuous spontaneous localization model (CSL), in the cosmological context, might be used to provide a solution to the mentioned issues by considering a dynamical reduction of the wave function. The CSL model has been applied to the inflationary universe before and different conclusions have been obtained. In this letter, we use a different approach to implement the CSL model during inflation. In particular, in addition to accounting for the quantum-to-classical transition, we use the CSL model to generate the primordial perturbations, that is, the dynamical evolution provided by the CSL model is responsible for the transition from a homogeneous and isotropic initial state to a final one lacking such symmetries. Our approach leads to results that can be clearly distinguished from preceding works. Specifically, the scalar and tensor power spectra are not time-dependent, and one retains the amplification mechanism of the CSL model. Moreover, our framework depends only on one parameter (the CSL parameter) and its value is consistent with cosmological and laboratory observations. (orig.)

  7. Developing International Attack Strategy: the Case of Smartcard Expansion at PT CSL

    OpenAIRE

    Hidayah, Taufiqul; Toha, Mohamad

    2013-01-01

    PT CSL is the biggest smartcard manufacturer in Indonesia which has occupied more than 50% of domestic market share. CSL should expand its market abroad to avoid from KPPU regulation related with monopolistic. For competing with global competitors, CSL should position its products and solutions among global manufacturers. CSL should have appropriate attack strategy while entering certain market/segment to fight with existing competitors. Both strategies must be supported International corpora...

  8. The Effects of 3D Immersion on CSL Students' Listening Comprehension

    Science.gov (United States)

    Lan, Yu-Ju; Liao, Chia-Ying

    2018-01-01

    The study aimed at enhancing Chinese as a second language (CSL) students' listening comprehension by using authentic contexts in Second Life (SL). Twenty-seven CSL students from 4 countries participated in the 6-week study. A within-subject design was adopted to confirm the effects of 3D immersive experiences on CSL students' listening…

  9. The Berne Model and Advertising Messages: A Psychographic Study.

    Science.gov (United States)

    Martin, Charles H.

    This study relates Eric Berne's theory of Transactional Analysis to the effectiveness of advertising messages. A 30 item Personality Mode Test was constructed in order to assess subject agreement with statements reflecting Berne's three personality states: parent (social evaluative), adult (controlled rationality), and child (emotiveness). After…

  10. Technology evaluation: HPV vaccine (quadrivalent), Aventis Pasteur MSD/CSL.

    Science.gov (United States)

    Reinis, Milan

    2004-04-01

    CSL, licensee of UniQuest's HPV technology, and Aventis Pasteur MSD (a joint venture between Merck & Co and Aventis) are jointly developing a vaccine for the potential prophylaxis of genital warts and cervical cancer caused by human papilloma virus infection. Enrollment for a phase III trial has been completed.

  11. Dynamics of the Gay-Berne fluid

    International Nuclear Information System (INIS)

    de Miguel, E.; Rull, L.F.; Gubbins, K.E.

    1992-01-01

    Using molecular-dynamics computer simulation, we study the dynamical behavior of the isotropic and nematic phases of highly anisotropic molecular fluids. The interactions are modeled by means of the Gay-Berne potential with anisotropy parameters κ=3 and κ'=5. The linear-velocity autocorrelation function shows no evidence of a negative region in the isotropic phase, even at the higher densities considered. The self-diffusion coefficient parallel to the molecular axis shows an anomalous increase with density as the system enters the nematic region. This enhancement in parallel diffusion is also observed in the isotropic side of the transition as a precursor effect. The molecular reorientation is discussed in the light of different theoretical models. The Debye diffusion model appears to explain the reorientational mechanism in the nematic phase. None of the models gives a satisfactory account of the reorientation process in the isotropic phase

  12. Bern-Kosower rule for scalar QED

    International Nuclear Information System (INIS)

    Daikouji, K.; Shino, M.; Sumino, Y.

    1996-01-01

    We derive a full Bern-Kosower-type rule for scalar QED starting from quantum field theory: we derive a set of rules for calculating S-matrix elements for any processes at any order of the coupling constant. A gauge-invariant set of diagrams in general is first written in the world line path-integral expression. Then we integrate over x(τ), and the resulting expression is given in terms of a correlation function on the world line left-angle x(τ)x(τ ' )right-angle. Simple rules to decompose the correlation function into basic elements are obtained. A gauge transformation known as the integration by parts technique can be used to reduce the number of independent terms before integration over proper-time variables. The surface terms can be omitted provided the external scalars are on shell. Also, we clarify correspondence to the conventional Feynman rule, which enabled us to avoid any ambiguity coming from the infinite dimensionality of the path-integral approach. copyright 1996 The American Physical Society

  13. Role of CSL-dependent and independent Notch signaling pathways in cell apoptosis.

    Science.gov (United States)

    Zeng, Chong; Xing, Rui; Liu, Jing; Xing, Feiyue

    2016-01-01

    Apoptosis is a normally biological phenomenon in various organisms, involving complexly molecular mechanisms with a series of signaling processes. Notch signaling is found evolutionarily conserved in many species, playing a critical role in embryonic development, normal tissue homeostasis, angiogenesis and immunoregulation. The focus of this review is on currently novel advances about roles of CSL-dependent and independent Notch signaling pathways in cell apoptosis. The CSL can bind Notch intracellular domain (NIC) to act as a switch in mediating transcriptional activation or inactivation of the Notch signaling pathway downstream genes in the nucleus. It shows that CSL-dependent signaling regulates the cell apoptosis through Hes-1-PTEN-AKT-mTOR signaling, but rather the CSL-independent signaling mediates the cell apoptosis possibly via NIC-mTORC2-AKT-mTOR signaling, providing a new insight into apoptotic mechanisms.

  14. International Congress on Whiplash Associated Disorders - The Bern Symposium

    Directory of Open Access Journals (Sweden)

    Harold Merskey

    2003-01-01

    Full Text Available We take pleasure in this issue in presenting a series of plenary session lectures and some additional contributions from the Bern Symposium, a meeting held in Berne, Switzerland from March 8 to 10, 2001. The symposium was organized by Dr Bogdan Radanov and colleagues from that city where they had themselves undertaken an enormous amount of classical work in the investigation of cervical sprain syndrome. Radanov's work resolved a number of definitive issues in the investigation of whiplash, despite those who say otherwise for medicolegal reasons. He and his colleagues showed clearly that pain after cervical sprain injury was primarily correlated with the intensity of the initial pain, with the occurrence of premorbid injury and with age. Personality status before injury had no bearing on the outcome, and the intensity of pain at the beginning of injury was also correlated with depression or cognitive change later (1.

  15. 75 FR 21164 - Safety Zone; Neuse River, New Bern, NC

    Science.gov (United States)

    2010-04-23

    ... Ada Mae, the 72' Gaff Rigged Schooner Jeanie B, and the 58' Brigantine Meka II. The sailing vessels... following points; onshore at New Bern in approximate position 35[deg]06'12'' W; 077[deg]02'12'' N thence to... approximate position 35[deg]06'12'' W; 077[deg]02'12'' N thence to 35[deg]05'52'' W; 077[deg]02'15'' N thence...

  16. Crystalline roof glazing - Westside shopping centre, Berne; Kristalline Dachverglasungen

    Energy Technology Data Exchange (ETDEWEB)

    Enkerli, W.

    2009-07-01

    This illustrated article takes a look at the new shopping and leisure centre on the western outskirts of Berne, Switzerland. In particular, the roof of this unusual building over the motorway with its sloping walls and zig-zag design is looked at. The centre's shopping mall, adventure baths and spa, a multiplex cinema, an old peoples' home and a hotel are briefly discussed, as is the embedding of the centre in its suburban environment. The roof construction with its crystalline skylights is examined and discussed in detail. The centre's building technical services are also briefly commented on.

  17. Frontiers in Medicinal Chemistry 2017 in Bern, Switzerland.

    Science.gov (United States)

    Probst, Daniel; Heitz, Marc; Poirier, Marion; Gan, Bee Ha; Delalande, Clémence; Reymond, Jean-Louis

    2017-10-09

    Sharing capital ideas: The 2017 Frontiers in Medicinal Chemistry (FiMC) conference, organized jointly by the German Chemical Society, the German Pharmaceutical Society, and the Swiss Chemical Society, was held at the Department of Chemistry and Biochemistry of the University of Bern in February 2017. Herein we summarize the many conference highlights, and look forward to the next FiMC meeting, to be held in Jena (Germany) in March 2018. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  18. The cyclotron laboratory and the RFQ accelerator in Bern

    International Nuclear Information System (INIS)

    Braccini, S.; Ereditato, A.; Kreslo, I.; Nirkko, M.; Weber, M.; Scampoli, P.; Bremen, K. von

    2013-01-01

    Two proton accelerators have been recently put in operation in Bern: an 18 MeV cyclotron and a 2 MeV RFQ linac. The commercial IBA 18/18 cyclotron, equipped with a specifically conceived 6 m long external beam line ending in a separate bunker, will provide beams for routine 18-F and other PET radioisotope production as well as for novel detector, radiation biophysics, radioprotection, radiochemistry and radiopharmacy developments. The accelerator is embedded into a complex building hosting two physics laboratories and four Good Manufacturing Practice (GMP) laboratories. This project is the result of a successful collaboration between the Inselspital, the University of Bern and private investors, aiming at the constitution of a combined medical and research centre able to provide the most cutting-edge technologies in medical imaging and cancer radiation therapy. The cyclotron is complemented by the RFQ with the primary goals of elemental analysis via Particle Induced Gamma Emission (PIGE), and the detection of potentially dangerous materials with high nitrogen content using the Gamma-Resonant Nuclear Absorption (GRNA) technique. In this context, beam instrumentation devices have been developed, in particular an innovative beam profile monitor based on doped silica fibres and a setup for emittance measurements using the pepper-pot technique. On this basis, the establishment of a proton therapy centre on the campus of the Inselspital is in the phase of advanced study

  19. Shear viscosity of binary mixtures: The Gay–Berne potential

    International Nuclear Information System (INIS)

    Khordad, R.

    2012-01-01

    Highlights: ► Most useful potential model to study the real systems is the Gay–Berne (GB) potential. ► We use GB model to examine thermodynamical properties of some anisotropic binary mixtures in two different phases. ► The integral equation methods are applied to solve numerically the Percus–Yevick (PY) equation. ► We obtain expansion coefficients of correlation functions needed to calculate the properties of studied mixtures. ► The results are compared with the available experimental data [e.g., HFC-125 + propane, R-125/143a, methanol + toluene, etc.] - Abstract: The Gay–Berne (GB) potential model is an interesting and useful model to study the real systems. Using the potential model, we intend to examine the thermodynamical properties of some anisotropic binary mixtures in two different phases, liquid and gas. For this purpose, we apply the integral equation method and solve numerically the Percus–Yevick (PY) integral equation. Then, we obtain the expansion coefficients of correlation functions to calculate the thermodynamical properties. Finally, we compare our results with the available experimental data [e.g., HFC-125 + propane, R-125/143a, methanol + toluene, benzene + methanol, cyclohexane + ethanol, benzene + ethanol, carbon tetrachloride + ethyl acetate, and methanol + ethanol]. The results show that the GB potential model is capable for predicting the thermodynamical properties of binary mixtures with acceptable accuracy.

  20. The cyclotron laboratory and the RFQ accelerator in Bern

    Energy Technology Data Exchange (ETDEWEB)

    Braccini, S.; Ereditato, A.; Kreslo, I.; Nirkko, M.; Weber, M. [Albert Einstein Center for Fundamental Physics, Laboratory for High Energy Physics (LHEP), University of Bern, Sidlerstrasse 5, CH-3012 Bern (Switzerland); Scampoli, P. [Albert Einstein Center for Fundamental Physics, Laboratory for High Energy Physics (LHEP), University of Bern, Sidlerstrasse 5, CH-3012 Bern, Switzerland and Department of Physical Sciences, University Federico II, Via Cintia, I-60126 Napoli (Italy); Bremen, K. von [SWAN Isotopen AG, Inselspital, CH-3010 Bern (Switzerland)

    2013-07-18

    Two proton accelerators have been recently put in operation in Bern: an 18 MeV cyclotron and a 2 MeV RFQ linac. The commercial IBA 18/18 cyclotron, equipped with a specifically conceived 6 m long external beam line ending in a separate bunker, will provide beams for routine 18-F and other PET radioisotope production as well as for novel detector, radiation biophysics, radioprotection, radiochemistry and radiopharmacy developments. The accelerator is embedded into a complex building hosting two physics laboratories and four Good Manufacturing Practice (GMP) laboratories. This project is the result of a successful collaboration between the Inselspital, the University of Bern and private investors, aiming at the constitution of a combined medical and research centre able to provide the most cutting-edge technologies in medical imaging and cancer radiation therapy. The cyclotron is complemented by the RFQ with the primary goals of elemental analysis via Particle Induced Gamma Emission (PIGE), and the detection of potentially dangerous materials with high nitrogen content using the Gamma-Resonant Nuclear Absorption (GRNA) technique. In this context, beam instrumentation devices have been developed, in particular an innovative beam profile monitor based on doped silica fibres and a setup for emittance measurements using the pepper-pot technique. On this basis, the establishment of a proton therapy centre on the campus of the Inselspital is in the phase of advanced study.

  1. 75 FR 23592 - Safety Zone; Neuse River, New Bern, NC; Correction

    Science.gov (United States)

    2010-05-04

    ... the waters of the Neuse River, New Bern, North Carolina on May 8, 2010. The safety zone published with...-AA00 Safety Zone; Neuse River, New Bern, NC; Correction ACTION: Temporary final rule; correction. SUMMARY: In the Federal Register published on April 23, 2010, the Coast Guard established a temporary...

  2. The Bern Simple Climate Model (BernSCM) v1.0: an extensible and fully documented open-source re-implementation of the Bern reduced-form model for global carbon cycle-climate simulations

    Science.gov (United States)

    Strassmann, Kuno M.; Joos, Fortunat

    2018-05-01

    The Bern Simple Climate Model (BernSCM) is a free open-source re-implementation of a reduced-form carbon cycle-climate model which has been used widely in previous scientific work and IPCC assessments. BernSCM represents the carbon cycle and climate system with a small set of equations for the heat and carbon budget, the parametrization of major nonlinearities, and the substitution of complex component systems with impulse response functions (IRFs). The IRF approach allows cost-efficient yet accurate substitution of detailed parent models of climate system components with near-linear behavior. Illustrative simulations of scenarios from previous multimodel studies show that BernSCM is broadly representative of the range of the climate-carbon cycle response simulated by more complex and detailed models. Model code (in Fortran) was written from scratch with transparency and extensibility in mind, and is provided open source. BernSCM makes scientifically sound carbon cycle-climate modeling available for many applications. Supporting up to decadal time steps with high accuracy, it is suitable for studies with high computational load and for coupling with integrated assessment models (IAMs), for example. Further applications include climate risk assessment in a business, public, or educational context and the estimation of CO2 and climate benefits of emission mitigation options.

  3. The Bern Simple Climate Model (BernSCM v1.0: an extensible and fully documented open-source re-implementation of the Bern reduced-form model for global carbon cycle–climate simulations

    Directory of Open Access Journals (Sweden)

    K. M. Strassmann

    2018-05-01

    Full Text Available The Bern Simple Climate Model (BernSCM is a free open-source re-implementation of a reduced-form carbon cycle–climate model which has been used widely in previous scientific work and IPCC assessments. BernSCM represents the carbon cycle and climate system with a small set of equations for the heat and carbon budget, the parametrization of major nonlinearities, and the substitution of complex component systems with impulse response functions (IRFs. The IRF approach allows cost-efficient yet accurate substitution of detailed parent models of climate system components with near-linear behavior. Illustrative simulations of scenarios from previous multimodel studies show that BernSCM is broadly representative of the range of the climate–carbon cycle response simulated by more complex and detailed models. Model code (in Fortran was written from scratch with transparency and extensibility in mind, and is provided open source. BernSCM makes scientifically sound carbon cycle–climate modeling available for many applications. Supporting up to decadal time steps with high accuracy, it is suitable for studies with high computational load and for coupling with integrated assessment models (IAMs, for example. Further applications include climate risk assessment in a business, public, or educational context and the estimation of CO2 and climate benefits of emission mitigation options.

  4. Shear viscosity of binary mixtures: The Gay-Berne potential

    Science.gov (United States)

    Khordad, R.

    2012-05-01

    The Gay-Berne (GB) potential model is an interesting and useful model to study the real systems. Using the potential model, we intend to examine the thermodynamical properties of some anisotropic binary mixtures in two different phases, liquid and gas. For this purpose, we apply the integral equation method and solve numerically the Percus-Yevick (PY) integral equation. Then, we obtain the expansion coefficients of correlation functions to calculate the thermodynamical properties. Finally, we compare our results with the available experimental data [e.g., HFC-125 + propane, R-125/143a, methanol + toluene, benzene + methanol, cyclohexane + ethanol, benzene + ethanol, carbon tetrachloride + ethyl acetate, and methanol + ethanol]. The results show that the GB potential model is capable for predicting the thermodynamical properties of binary mixtures with acceptable accuracy.

  5. New bern biomass to energy project Phase I: Feasibility study

    Energy Technology Data Exchange (ETDEWEB)

    Parson, F.; Bain, R.

    1995-10-01

    Weyerhaeuser, together with Amoco and Carolina Power & Light, performed a detailed evaluation of biomass gasification and enzymatic processing of biomass to ethanol. This evaluation assesses the potential of these technologies for commercial application to determine which technology offers the best opportunity at this time to increase economic productivity of forest resources in an environmentally sustainable manner. The work performed included preparation of site-specific plant designs that integrate with the Weyerhaeuser New Bern, North Carolina pulp mill to meet overall plant energy requirements, cost estimates, resource and product market assessments, and technology evaluations. The Weyerhaeuser team was assisted by Stone & Webster Engineering Corporation and technology vendors in developing the necessary data, designs, and cost information used in this comparative study. Based on the information developed in this study and parallel evaluations performed by Weyerhaeuser and others, biomass gasification for use in power production appears to be technically and economically viable. Options exist at the New Bern mill which would allow commercial scale demonstration of the technology in a manner that would serve the practical energy requirements of the mill. A staged project development plan has been prepared for review. The plan would provide for a low-risk and cost demonstration of a biomass gasifier as an element of a boiler modification program and then allow for timely expansion of power production by the addition of a combined cycle cogeneration plant. Although ethanol technology is at an earlier stage of development, there appears to be a set of realizable site and market conditions which could provide for an economically attractive woody-biomass-based ethanol facility. The market price of ethanol and the cost of both feedstock and enzyme have a dramatic impact on the projected profitability of such a plant.

  6. CSL protein regulates transcription of genes required to prevent catastrophic mitosis in fission yeast.

    Science.gov (United States)

    Převorovský, Martin; Oravcová, Martina; Zach, Róbert; Jordáková, Anna; Bähler, Jürg; Půta, František; Folk, Petr

    2016-11-16

    For every eukaryotic cell to grow and divide, intricately coordinated action of numerous proteins is required to ensure proper cell-cycle progression. The fission yeast Schizosaccharomyces pombe has been instrumental in elucidating the fundamental principles of cell-cycle control. Mutations in S. pombe 'cut' (cell untimely torn) genes cause failed coordination between cell and nuclear division, resulting in catastrophic mitosis. Deletion of cbf11, a fission yeast CSL transcription factor gene, triggers a 'cut' phenotype, but the precise role of Cbf11 in promoting mitotic fidelity is not known. We report that Cbf11 directly activates the transcription of the acetyl-coenzyme A carboxylase gene cut6, and the biotin uptake/biosynthesis genes vht1 and bio2, with the former 2 implicated in mitotic fidelity. Cbf11 binds to a canonical, metazoan-like CSL response element (GTGGGAA) in the cut6 promoter. Expression of Cbf11 target genes shows apparent oscillations during the cell cycle using temperature-sensitive cdc25-22 and cdc10-M17 block-release experiments, but not with other synchronization methods. The penetrance of catastrophic mitosis in cbf11 and cut6 mutants is nutrient-dependent. We also show that drastic decrease in biotin availability arrests cell proliferation but does not cause mitotic defects. Taken together, our results raise the possibility that CSL proteins play conserved roles in regulating cell-cycle progression, and they could guide experiments into mitotic CSL functions in mammals.

  7. Evaluating CSL/CFL Website Usability: A User-Centered Design Approach

    Science.gov (United States)

    Huang, Chung-Kai; Hsin, Ching-O; Chiu, Chiung-Hui

    2010-01-01

    With the widespread availability of Internet and computer technology, on-line web-based learning has become prevalent in the field of teaching Chinese as a second/foreign language (CSL/CFL). This study examined the concepts of usability and types of design elements that help construct an effective web-based learning environment, as well as their…

  8. ??? - Bern 1935 - Tartu 1995 : [Protokolõ sionskihh mudretsov] / Kristiina Ross ; ter.: Majana Abramson

    Index Scriptorium Estoniae

    Ross, Kristiina, 1955-

    1996-01-01

    Sisu: Tartu 1995; 'Protokolõ' kak takovõje; Original 'Protokolov'; Predõstorija sozdanija mifa o pokorenii mira jevrejami - volnõmi kamenshtshikami; 'Protokolõ' v ideologitsheskom hodu; 'Protokolõ' i natsism; Bern 1935-1937

  9. In Bern high-energy physics shares proton beams with the hospital

    CERN Multimedia

    CERN Bulletin

    2011-01-01

    A joint venture bringing together public institutions and private companies is building a new facility on the campus of Inselspital, Bern’s university hospital. The facility will host a cyclotron for the production of radiopharmaceuticals for use in PET as well as in multidisciplinary research laboratories for the development of new products for medical imaging. The Laboratory for High Energy Physics (LHEP) of Bern University, which is deeply involved in the project, will have access to a dedicated beam line and specialized labs.     Construction of the new facility is ongoing at Bern's University Hospital, where the cyclotron will be installed.   The first Bern Cyclotron symposium will take place on 6 and 7 June this year. The event is being organised by LHEP in collaboration with Bern’s Inselspital and will bring together experts – including several from CERN – to promote research activities at the new Bern Cyclotron Laboratory. &ld...

  10. Genome-wide analysis of the cellulose synthase-like (Csl) gene family in bread wheat (Triticum aestivum L.).

    Science.gov (United States)

    Kaur, Simerjeet; Dhugga, Kanwarpal S; Beech, Robin; Singh, Jaswinder

    2017-11-03

    Hemicelluloses are a diverse group of complex, non-cellulosic polysaccharides, which constitute approximately one-third of the plant cell wall and find use as dietary fibres, food additives and raw materials for biofuels. Genes involved in hemicellulose synthesis have not been extensively studied in small grain cereals. In efforts to isolate the sequences for the cellulose synthase-like (Csl) gene family from wheat, we identified 108 genes (hereafter referred to as TaCsl). Each gene was represented by two to three homeoalleles, which are named as TaCslXY_ZA, TaCslXY_ZB, or TaCslXY_ZD, where X denotes the Csl subfamily, Y the gene number and Z the wheat chromosome where it is located. A quarter of these genes were predicted to have 2 to 3 splice variants, resulting in a total of 137 putative translated products. Approximately 45% of TaCsl genes were located on chromosomes 2 and 3. Sequences from the subfamilies C and D were interspersed between the dicots and grasses but those from subfamily A clustered within each group of plants. Proximity of the dicot-specific subfamilies B and G, to the grass-specific subfamilies H and J, respectively, points to their common origin. In silico expression analysis in different tissues revealed that most of the genes were expressed ubiquitously and some were tissue-specific. More than half of the genes had introns in phase 0, one-third in phase 2, and a few in phase 1. Detailed characterization of the wheat Csl genes has enhanced the understanding of their structural, functional, and evolutionary features. This information will be helpful in designing experiments for genetic manipulation of hemicellulose synthesis with the goal of developing improved cultivars for biofuel production and increased tolerance against various stresses.

  11. N-termini of fungal CSL transcription factors are disordered, enriched in regulatory motifs and inhibit DNA binding in fission yeast.

    Directory of Open Access Journals (Sweden)

    Martin Převorovský

    Full Text Available CSL (CBF1/RBP-Jκ/Suppressor of Hairless/LAG-1 transcription factors are the effector components of the Notch receptor signalling pathway, which is critical for metazoan development. The metazoan CSL proteins (class M can also function in a Notch-independent manner. Recently, two novel classes of CSL proteins, designated F1 and F2, have been identified in fungi. The role of the fungal CSL proteins is unclear, because the Notch pathway is not present in fungi. In fission yeast, the Cbf11 and Cbf12 CSL paralogs play antagonistic roles in cell adhesion and the coordination of cell and nuclear division. Unusually long N-terminal extensions are typical for fungal and invertebrate CSL family members. In this study, we investigate the functional significance of these extended N-termini of CSL proteins.We identify 15 novel CSL family members from 7 fungal species and conduct bioinformatic analyses of a combined dataset containing 34 fungal and 11 metazoan CSL protein sequences. We show that the long, non-conserved N-terminal tails of fungal CSL proteins are likely disordered and enriched in phosphorylation sites and PEST motifs. In a case study of Cbf12 (class F2, we provide experimental evidence that the protein is proteolytically processed and that the N-terminus inhibits the Cbf12-dependent DNA binding activity in an electrophoretic mobility shift assay.This study provides insight into the characteristics of the long N-terminal tails of fungal CSL proteins that may be crucial for controlling DNA-binding and CSL function. We propose that the regulation of DNA binding by Cbf12 via its N-terminal region represents an important means by which fission yeast strikes a balance between the class F1 and class F2 paralog activities. This mode of regulation might be shared with other CSL-positive fungi, some of which are relevant to human disease and biotechnology.

  12. The Graduate School of Climate Sciences, University of Bern

    Science.gov (United States)

    Martin, L.

    2012-04-01

    The Graduate School of Climate Sciences, University of Bern, offers a specialised M.Sc. and a Ph.D. study programme in climate sciences. The graduate school has a highly interdisciplinary profile involving not only natural sciences, but also humanities/history, economics and law. The ten participating institutes with a total of 45 academics provide expertise in long-term climate variability, climate modelling, climate reconstruction, predictability of the future climate and extreme events, the impact of climate change on ecosystems and climate risks for society and economy. The graduate school is fully compliant with the Bologna Accords and collaborates closely with the sister institution C2SM at ETH Zurich by, e.g., jointly organised lectures. There are currently 23 master and 37 doctoral students in the programme. These originate from the University of Bern (28 %), from other Swiss universities (30 %) and from foreign universities (42 %). Comprehensive information about the Graduate School of Climate Sciences is available at http://www.climatestudies.unibe.ch . The M.Sc. in Climate Sciences programme (120 ECTS credits) is designed to attract students from all disciplines in natural sciences and offers them a tailor-made curriculum to reach their career aspirations. The students make their own course selection according to their profile envisaged (specialised versus broad education) and ideally already guided by a job perspective. Selecting the courses and the topic of the master thesis they specialise in one of five fields: climate and earth system science; atmospheric science; economics; economic, social and environmental history; statistics. Several courses are organised jointly with public authorities and the private industry, e.g. from experts working in the insurance business, in weather forecasting or in environmental pollution control. This provides the students hands-on experience and contacts to future employers. The master thesis (60 ECTS) involves the

  13. Prediction of filamentous process performance attributes by CSL quality assessment using mid-infrared spectroscopy and chemometrics.

    Science.gov (United States)

    Hofer, Alexandra; Kamravamanesh, Donya; Bona-Lovasz, Judit; Limbeck, Andreas; Lendl, Bernhard; Herwig, Christoph; Fricke, Jens

    2018-01-10

    Every biopharmaceutical production process aims for control strategies to achieve process robustness in order to ensure consistent product quality. Process variability can origin from process parameters, the biological nature as well as from high lot-to-lot variability of raw materials. In filamentous processes raw materials with very complex matrices, such as corn steep liquor (CSL), are used, which are especially challenging to characterize. In this study, CSL was characterized in detail for its ingredients presenting an overall composition of its matrix of 50 analyzed components (19 amino acids, 5 organic acids, 8 reducing sugars, 7 water-soluble vitamins and 11 trace elements/minerals) in order to facilitate analytical reduction to fingerprinting methods FT-MIR was evaluated as fast and non-destructive spectroscopic fingerprinting method for adequate assessment of CSL quality. Feasibility of this method was shown by the correlation of certain bands in the spectra to substance groups present in CSL, such as the Amide I and II band and amino acids, respectively. Additionally, applicability of FT-MIR could be shown for classification of different CSL lots differing in provider and corn quality as well as for predictability of process performance attributes. The latter was demonstrated on a fed-batch filamentous fungi process for the production of antibiotics. By multivariate data analysis, it could be shown that CSL quality assessment via FT-MIR can be used for the prediction of maximal biomass generated in the process, with a correlation coefficient R 2 of 0.964, as well as for the prediction of an unwanted impurity. The combination of a fast and easy method for CSL quality assessment and correlations of this quality with process performance attributes may facilitate the establishment of a risk-based acceptance criteria for raw material quality release of CSL. As CSL is a frequent used raw material, we believe that this method will also be useful for other

  14. Investigation into the temperature dependence of isotropic- nematic phase transition of Gay- Berne liquid crystals

    Directory of Open Access Journals (Sweden)

    A Avazpour

    2014-12-01

    Full Text Available Density functional approach was used to study the isotropic- nematic (I-N transition and calculate the values of freezing parameters of the Gay- Berne liquid crystal model. New direct and pair correlation functions of a molecular fluid with Gay- Berne pair potential were used. These new functions were used in density functional theory as input to calculate the isotropic- nematic transition densities for elongation at various reduced temperatures. It was observed that the isotropic- nematic transition densities increase as the temperature increases. It was found that the new direct correlation function is suitable to study the isotropic- nematic transition of Gay- Berne liquids. Comparison to other works showed qualitative agreement

  15. Rate Reduction for State-labelled Markov Chains with Upper Time-bounded CSL Requirements

    Directory of Open Access Journals (Sweden)

    Bharath Siva Kumar Tati

    2016-07-01

    Full Text Available This paper presents algorithms for identifying and reducing a dedicated set of controllable transition rates of a state-labelled continuous-time Markov chain model. The purpose of the reduction is to make states to satisfy a given requirement, specified as a CSL upper time-bounded Until formula. We distinguish two different cases, depending on the type of probability bound. A natural partitioning of the state space allows us to develop possible solutions, leading to simple algorithms for both cases.

  16. Technology transfer in the energy domain in the Canton of Berne. Evaluation 1996. Final Report; Technologievermittlung im Energiebereich des Kantons Bern. Begleitende Evaluation 1996. Schlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Meier, R.; Schaerer, H.U.; Jakob, E.; Kriesi, R.; Spahr, I.; Schaefer, H.; Kuster, J.

    1996-12-01

    The Canton of Bern has promoted the transfer of technology since 1993. Together with the Department of Energy Economy, it began a pilot project in this field in 1995. An energy expert from the private sector was given the task of building up contacts between the energy research and industry. In this report, an independent expert evaluates this pilot project as positive and recommends its continuation. (author) figs., tabs., 10 refs.

  17. Randomized trial to compare the safety and immunogenicity of CSL Limited's 2009 trivalent inactivated influenza vaccine to an established vaccine in United States children.

    Science.gov (United States)

    Brady, Rebecca C; Hu, Wilson; Houchin, Vonda G; Eder, Frank S; Jackson, Kenneth C; Hartel, Gunter F; Sawlwin, Daphne C; Albano, Frank R; Greenberg, Michael

    2014-12-12

    A trivalent inactivated influenza vaccine (CSL's TIV, CSL Limited) was licensed under USA accelerated approval regulations for use in persons≥18 years. We performed a randomized, observer-blind study to assess the safety and immunogenicity of CSL's TIV versus an established US-licensed vaccine in a population≥6 months to vaccination history determined the dosing regimen (one or two vaccinations). Subjects received CSL's TIV (n=739) or the established vaccine (n=735) in the autumn of 2009. Serum hemagglutination-inhibition titers were determined pre-vaccination and 30 days after the last vaccination. No febrile seizures or other vaccine-related SAEs were reported. After the first vaccination for Cohorts A and B, respectively, the relative risks of fever were 2.73 and 2.32 times higher for CSL's TIV compared to the established vaccine. Irritability and loss of appetite (for Cohort A) and malaise (for Cohort B) were also significantly higher for CSL's TIV compared to the established vaccine. Post-vaccination geometric mean titers (GMTs) for CSL's TIV versus the established vaccine were 385.49 vs. 382.45 for H1N1; 669.13 vs. 705.61 for H3N2; and 100.65 vs. 93.72 for B. CSL's TIV demonstrated immunological non-inferiority to the established vaccine in all cohorts. Copyright © 2014 Elsevier Ltd. All rights reserved.

  18. 75 FR 69878 - Drawbridge Operation Regulation; Neuse River, New Bern, NC

    Science.gov (United States)

    2010-11-16

    ... Operation Regulation; Neuse River, New Bern, NC AGENCY: Coast Guard, DHS. ACTION: Notice of temporary deviation from regulations. SUMMARY: The Commander, Fifth Coast Guard District, has issued a temporary... is given. NSR has requested a temporary deviation to the existing regulations for the Neuse River...

  19. Subglacial tunnel valleys in the Alpine foreland: an example from Bern, Switzerland

    International Nuclear Information System (INIS)

    Duerst Stucki, M.; Reber, R.; Schlunegger, F.

    2010-01-01

    The morphology of the Alpine and adjacent landscapes is directly related to glacial erosion and associated sediment transport. Here we report the effects of glacio-hydrologic erosion on bedrock topography in the Swiss Plateau. Specifically, we identify the presence of subsurface valleys beneath the city of Bern and discuss their genesis. Stratigraphic investigations of more than 4'000 borehole data within a 430 km 2 -large area reveal the presence of a network of >200 m-deep and 1'000 m-wide valleys. They are flat floored with steep sided walls and are filled by Quaternary glacial deposits. The central valley beneath Bern is straight and oriented towards the NNW, with valley flanks more than 20 o steep. The valley bottom has an irregular undulating profile along the thalweg, with differences between sills and hollows higher than 50-100 m over a reach of 4 km length. Approximately 500 m high bedrock highlands flank the valley network. The highlands are dissected by up to 80 m-deep and 500 m-broad hanging valleys that currently drain away from the axis of the main valley. We interpret the valleys beneath the city of Bern to be a tunnel valley network which originated from subglacial erosion by melt water. The highland valleys served as proglacial meltwater paths and are hanging with respect to the trunk system, indicating that these incipient highland systems as well as the main gorge beneath Bern formed by glacial melt water under pressure. (authors)

  20. Formation of tilted smectic-C liquid crystal phase in polar Gay-Berne molecules

    International Nuclear Information System (INIS)

    Saha, J.; Bose, T.R.; Ghosh, D.; Saha, M.

    2005-01-01

    We perform molecular dynamics simulation for a system of Gay-Berne molecules having two terminal dipole moments to generate tilted smectic-C liquid crystal phase. We investigate the effect of dipolar orientation with respect to the long molecular axis on phase behaviour. The study indicates that larger dipolar angle can give rise to greater tilt in molecular organization within a layer

  1. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to a combination of Lactobacillus delbrueckii subsp. bulgaricus AY/CSL (LMG P-17224) and Streptococcus thermophilus 9Y/CSL (LMG P-17225) and “beneficial modulation

    DEFF Research Database (Denmark)

    Tetens, Inge

    of a health claim related to a combination of Lactobacillus delbrueckii subsp. bulgaricus AY/CSL (LMG P-17224) and Streptococcus thermophilus 9Y/CSL (LMG P-17225) and “beneficial modulation of intestinal microflora”. The scope of the application was proposed to fall under a health claim referring to children......’s development and health. The food constituent that is the subject of the health claim, a combination of L. delbrueckii subsp. bulgaricus AY/CSL (LMG P-17224) and S. thermophilus 9Y/CSL (LMG P-17225), has not been sufficiently characterised. The claimed effect is “beneficial modulation of the intestinal...... that a cause and effect relationship has not been established between the consumption of the food constituent, the combination of L. delbrueckii subsp. bulgaricus AY/CSL (LMG P-17224) and S. thermophilus 9Y/CSL (LMG P-17225), and a beneficial physiological effect related to “beneficial modulation...

  2. On the spontaneous emission of electromagnetic radiation in the CSL model

    International Nuclear Information System (INIS)

    Donadi, Sandro; Deckert, Dirk-André; Bassi, Angelo

    2014-01-01

    Spontaneous photon emission in the Continuous Spontaneous Localization (CSL) model is studied one more time. In the CSL model each particle interacts with a noise field that induces the collapse of its wave function. As a consequence of this interaction, when the particle is electrically charged, it radiates. As discussed in Adler (2013) the formula for the emission rate, to first perturbative order, contains two terms: one is proportional to the Fourier component of the noise field at the same frequency as that of the emitted photon and one is proportional to the zero Fourier component of the noise field. As discussed in previous works, this second term seems unphysical. In Adler (2013) it was shown that the unphysical term disappears when the noise is confined to a bounded region and the final particle’s state is a wave packet. Here we investigate the origin of this unphysical term and why it vanishes according to the previous prescription. We will see that perturbation theory is formally not valid in the large time limit since the effect of the noise accumulates continuously in time. Therefore either one performs an exact calculation (or at least in some way includes higher order terms) as we do here, or one finds a way to make a perturbative calculation meaningful, e.g., by confining the system as in Adler (2013). -- Highlights: •We compute the electromagnetic radiation emission in collapse models. •Under only the dipole approximation, the equations of motion are solved exactly. •The electromagnetic interaction must be treated exactly. •In order to obtain the correct emission rate the particle must be bounded

  3. Bacterial infections in horses: a retrospective study at the University Equine Clinic of Bern.

    Science.gov (United States)

    Panchaud, Y; Gerber, V; Rossano, A; Perreten, V

    2010-04-01

    Bacterial infections present a major challenge in equine medicine. Therapy should be based on bacteriological diagnosis to successfully minimize the increasing number of infections caused by multidrug-resistant bacteria. The present study is a retrospective analysis of bacteriological results from purulent infections in horses admitted at the University Equine Clinic of Bern from 2004 to 2008. From 378 samples analyzed, 557 isolates were identified, of which Staphylococcus aureus, Streptococcus equi subsp. zooepidemicus and coliforms were the most common. Special attention was paid to infections with methicillin-resistant S. aureus (MRSA) ST398 and a non-MRSA, multidrug-resistant S. aureus clone ST1 (BERN100). Screening of newly-admitted horses showed that 2.2 % were carriers of MRSA. Consequent hygiene measures taken at the Clinic helped to overcome a MRSA outbreak and decrease the number of MRSA infections.

  4. Forum Engelberg 2004 to be launched in Bern on 13 November

    CERN Multimedia

    2003-01-01

    "Former French science minister Hubert Curien will be among major figures from European politics and science meeting in Bern on 13 November to launch the Forum Engelberg 2004.... Forum Engelberg provides a valuable platform for science and a forum for scientists and politicians to meet. The topic of its 2004 conference, to be held in Lucerne from 1 to 4 March 2004, is "Science on the Agenda of European Politics" (1 page).

  5. Computer simulation study of the nematic-vapour interface in the Gay-Berne model

    Science.gov (United States)

    Rull, Luis F.; Romero-Enrique, José Manuel

    2017-06-01

    We present computer simulations of the vapour-nematic interface of the Gay-Berne model. We considered situations which correspond to either prolate or oblate molecules. We determine the anchoring of the nematic phase and correlate it with the intermolecular potential parameters. On the other hand, we evaluate the surface tension associated to this interface. We find a corresponding states law for the surface tension dependence on the temperature, valid for both prolate and oblate molecules.

  6. Subglacial tunnel valleys in the Alpine foreland: an example from Bern, Switzerland

    Energy Technology Data Exchange (ETDEWEB)

    Duerst Stucki, M.; Reber, R.; Schlunegger, F.

    2010-12-15

    The morphology of the Alpine and adjacent landscapes is directly related to glacial erosion and associated sediment transport. Here we report the effects of glacio-hydrologic erosion on bedrock topography in the Swiss Plateau. Specifically, we identify the presence of subsurface valleys beneath the city of Bern and discuss their genesis. Stratigraphic investigations of more than 4'000 borehole data within a 430 km{sup 2}-large area reveal the presence of a network of >200 m-deep and 1'000 m-wide valleys. They are flat floored with steep sided walls and are filled by Quaternary glacial deposits. The central valley beneath Bern is straight and oriented towards the NNW, with valley flanks more than 20 {sup o} steep. The valley bottom has an irregular undulating profile along the thalweg, with differences between sills and hollows higher than 50-100 m over a reach of 4 km length. Approximately 500 m high bedrock highlands flank the valley network. The highlands are dissected by up to 80 m-deep and 500 m-broad hanging valleys that currently drain away from the axis of the main valley. We interpret the valleys beneath the city of Bern to be a tunnel valley network which originated from subglacial erosion by melt water. The highland valleys served as proglacial meltwater paths and are hanging with respect to the trunk system, indicating that these incipient highland systems as well as the main gorge beneath Bern formed by glacial melt water under pressure. (authors)

  7. Przystąpienie Stanów Zjednoczonych do Konwencji Berneńskiej

    OpenAIRE

    Kępiński, Marian

    1990-01-01

    The author presents main features of the Berne Convention Implementation Act of 1989. That law changed substantially the provisions of the Copyright Act of 1976, in particular those which dealt with formalities. Remaining formalities such as copyright notice, copyright registration and deposit of the work with the Copyright Office are, generally speaking, of permissive nature i.e. they are not conditions of copyright protection. However, there are aways advantages of complyi...

  8. Note: Modification of the Gay-Berne potential for improved accuracy and speed

    Science.gov (United States)

    Persson, Rasmus A. X.

    2012-06-01

    A modification of the Gay-Berne (GB) potential is proposed which is about 10% to 20% more speed efficient and statistically more accurate in reproducing the energy of interaction of two linear Lennard-Jones tetratomics when averaged over all orientations. For the special cases of end-to-end and side-by-side configurations, the new potential is equivalent to the GB one. A simple generalization to dissimilar particles of D∞h symmetry is presented but does not retain the superior agreement with respect to its GB counterpart, except at close range.

  9. The structural and thermodynamical properties of binary ellipsoidal fluid mixture Gay-Berne interaction

    Directory of Open Access Journals (Sweden)

    M. Moradi

    2007-06-01

    Full Text Available  In this paper, a uniform classical fluid mixture comprising ellipsoidal molecules is studied. This mixture is composed of two types of ellipsoidal molecules interacting through the Gay-Berne potential with different sizes at temperature T. For this system, the Ornstein-Zernike equation using the Percus-Yevick closure relation is solved. Then the direct correlation function, pair correlation function and the pressure of the fluid at temperature T are calculated. The obtained results are in agreement with the previous theories and the results of molecular dynamic computer simulation.

  10. A computer simulation of a potential derived from the gay-berne potential for lattice model

    Directory of Open Access Journals (Sweden)

    Habtamu Zewdie

    2000-06-01

    Full Text Available The lattice model of elongated molecules interacting via a potential derived from the Gay-Berne pair potential is proposed. We made a systematic study of the effect of varying the molecular elongation and intermolecular vector orientation dependence of the pair potential on the thermodynamic as well as the structural properties of liquid crystals. A Monte Carlo simulations of molecules placed at the site of a simple cubic lattice and interacting via the modified Gay-Berne potential with its nearest neighbours is performed. The internal energy, heat capacity, angular pair correlation function and scalar order parameter are obtained. The results are compared against predictions of molecular field theory, experimental results and that of other related simulations wherever possible. It is shown that for more elongated molecules the nematic-isotropic transition becomes stronger first order transition. For a given molecular elongation as the intermolecular vector orientation dependence becomes larger the nematic-isotropic transition becomes a stronger first order transition as measured by the rate of change of the order parameter and the divergence of the heat capacity. Scaling the potential well seems to have dramatic change on the effect of the potential well anisotropy on trends of nematic-isotropic transition temperature and divergence of the heat capacity. It is shown that the behaviour of many nematics can be described by proposed model with the elongation ratio of molecules and potential well anisotropy ranging from 3 to 5.

  11. Structures and Correlations in Ideally Aligned Polar Gay-Berne Systems

    International Nuclear Information System (INIS)

    Longa, L.; Cholewiak, G.; Stelzer, J.

    2000-01-01

    We study an ideally oriented system of Gay-Berne particles with embedded longitudinal dipole moments. While keeping the translational degrees of freedom of the molecules unrestricted we assume that their dipoles can be oriented either parallel or antiparallel to the positive z axis of the laboratory frame. At high temperatures, this frustrated Gay-Berne mesogen exhibits an ideally oriented nematic phase, which is the reference state of the system. In the limit of vanishing dipole moment nematic, smectic-A and smectic B phases are stable. Interestingly, by changing the magnitude and location of the molecular dipole in the nematic reference state we found dipole-induced smectic A, smectic B and tetragonal crystal phases, in addition to crystalline structures with smectic A d and A 2 -like dipolar organization. Various singlet, pair and triplet distribution functions were evaluated to elucidate short and long range organization in these phases. In particular, the importance of triplet correlations for a proper understanding of the structures and their local, dipolar organization is demonstrated. (author)

  12. Molecular dynamics simulations of Gay-Berne nematic liquid crystal: Elastic properties from direct correlation functions

    International Nuclear Information System (INIS)

    Stelzer, J.; Trebin, H.R.; Longa, L.

    1994-08-01

    We report NVT and NPT molecular dynamics simulations of a Gay-Berne nematic liquid crystal using generalization of recently proposed algorithm by Toxvaerd [Phys. Rev. E47, 343, 1993]. On the basis of these simulations the Oseen-Zoher-Frank elastic constants K 11 , K 22 and K 33 as well as the surface constants K 13 and K 24 have been calculated within the framework of the direct correlation function approach of Lipkin et al. [J. Chem. Phys. 82, 472 (1985)]. The angular coefficients of the direct pair correlation function, which enter the final formulas, have been determined from the computer simulation data for the pair correlation function of the nematic by combining the Ornstein-Zernike relation and the Wienier-Hopf factorization scheme. The unoriented nematic approximation has been assumed when constructing the reference, isotropic state of Lipkin et al. By an extensive study of the model over a wide range of temperatures, densities and pressures a very detailed information has been provided about elastic behaviour of the Gay-Berne nematic. Interestingly, it is found that the results for the surface elastic constants are qualitatively different than those obtained with the help of analytical approximations for the isotropic, direct pair correlation function. For example, the values of the surface elastic constants are negative and an order of magnitude smaller than the bulk elasticity. (author). 30 refs, 9 figs

  13. U(1) decoupling, Kleiss-Kuijf and Bern-Carrasco-Johansson relations in N=4 super Yang-Mills

    International Nuclear Information System (INIS)

    Jia Yin; Huang Rijun; Liu Changyong

    2010-01-01

    By using the Britto-Cachazo-Feng-Witten recursion relation of N=4 super Yang-Mills theory, we proved the color reflection, U(1) decoupling, Kleiss-Kuijf and Bern-Carrasco-Johansson relations for color-ordered amplitudes of N=4 super Yang-Mills theory. This proof verified the conjectured Bern-Carrasco-Johansson relations of matter fields. The proof depended only on general properties of superamplitudes. We showed also that the color reflection relation and U(1)-decoupling relation are special cases of Kleiss-Kuijf relations.

  14. Die Entwicklung des Innovationsmanagements an der Universitätsbibliothek Bern

    Directory of Open Access Journals (Sweden)

    Petra Redmond

    2015-11-01

    Full Text Available Das Innovationsmanagement dient der aktiven Gestaltung von Wandlungsprozessen, welche es der Bibliothek ermöglichen, rasch auf das sich schnell verändernde Bibliotheksumfeld zu reagieren. Innovativ sein heisst folglich auch, sich ständig zu verändern. Somit sollen sich auch im Innovationsmanagement Prozesse, Strukturen und Schwerpunkte stetig wandeln können und daher sollten sie laufend evaluiert werden. Aus diesem Grund wurde zu Beginn des Innovationsmanagements an der Universitätsbibliothek Bern beschlossen, nach zwei Jahren eine erste Evaluation durchzuführen, um die Prozesse und Kernaufgaben der aktuellen Situation anpassen zu können. Die Ergebnisse zeigten, dass eine stärkere Fokussierung auf strategische Handlungsschwerpunkte und die Förderung der internen Innovationskultur notwendig sind. Als neuen Schwerpunkt setzt die UB Bern nun auf die Implementierung einer systematischen Kundenforschung. Mögliche weitere Erfolgsfaktoren für ein gelingendes Innovationsmanagement sind die enge Verknüpfung zum Projektmanagement und die Einführung eines Produktmanagements. Innovation Management is actively shaping processes which will enable libraries to respond to rapidly changing environments. Being innovative means, therefore, being able to adapt to change and disruption. Processes, structures and focuses in innovation management are also subjected to change and, as a consequence, should be constantly evaluated. For this reason, at the beginning of the implementation of innovation management at University Library Bern the decision had been taken to perform an evaluation after 2 years in order to adjust the processes and core functions to the current situation. The results highlighted that both a stronger focus on strategic priorities and the promotion of internal culture of innovation are necessary. For this purpose, UB Bern focuses on the implementation of a systematic customer research. Other possible factors for successful innovation

  15. Perception of Medical Students about Communication Skills Laboratory (CSL) in a Rural Medical College of Central India.

    Science.gov (United States)

    Jagzape, Tushar Bharat; Jagzape, Arunita Tushar; Vagha, Jayant Dattatray; Chalak, Anita; Meshram, Revatdhamma Jagdish

    2015-12-01

    "The art of medicine is intricately tied to the art of communication." In traditional medical curriculum, communication is not taught formally and this leads to a gap in reliability and consistency of the teaching. Few studies have shown that much litigation against doctors is due to lack of communication and not because of lack of clinical expertise. Considering the importance of training in communication skills, it was included in the curriculum of students of DMIMS (DU), which has got probably the first communication skills lab in a medical college in India. To study the perception of medical students about usefulness of communication skills lab. This observational study was carried out at Communication Skills Lab (CSL) of Jawaharlal Nehru Medical College, Sawangi (M), Wardha, Maharasthra. Feedback was obtained with the help of a prevalidated questionnaire from 65 final MBBS students about their perception about utility of the module taught in the CSL including factors which helped and which hindered in learning. Descriptive statistics was used for the quantitative data and categorization for qualitative data. A total of 78.46% students were of the idea that CSL posting is must for all medical undergraduates. A 93.83% perceive that the module taught was very relevant and useful and were satisfied with the duration of posting (81.47%). A 78.46% students experienced improvement in their communication skills. They opined that more emphasis should be given on communication between doctor and patient (61.53%). The students found communication skills lab very useful. They desired more emphasis on communication between doctor and patient and sought more interactivity, video demonstrations to be part of the module.

  16. Source ventilation in the restaurant and in both large-scale catering establishments of the casino in Bern. Quellueftung im Restaurant und in den beiden Grosskuechen des Casino Bern

    Energy Technology Data Exchange (ETDEWEB)

    Anon,

    1991-08-01

    Source ventilation in the area of person concentrations has remarkable advantages: natural and economic, fresh air directly for the consumer, no draft phenomena, optimum dissipation of charge such as heat, smoke, etc., light efficiency. Structure and mode of function as well as the advantages of the system are shown by means of the casino in Bern. (BWI).

  17. EU Regulation 1143/2014 and the Bern Convention : Allied forces in the war on invasive alien species

    NARCIS (Netherlands)

    Trouwborst, Arie

    This article identifies and analyzes current and potential synergies between the new EU Regulation 1143/2014 on the prevention and management of the introduction and spread of invasive alien species on the one hand, and the Bern Convention on the Conservation of European Wildlife and Natural

  18. Monte Carlo study of one-dimensional confined fluids with Gay-Berne intermolecular potential

    Science.gov (United States)

    Moradi, M.; Hashemi, S.

    2011-11-01

    The thermodynamic quantities of a one dimensional system of particles with Gay-Berne model potential confined between walls have been obtained by means of Monte Carlo computer simulations. For a number of temperatures, the systems were considered and their density profiles, order parameter, pressure, configurational temperature and average potential energy per particle are reported. The results show that by decreasing the temperature, the soft particles become more ordered and they align to the walls and also they don't show any tendency to be near the walls at very low temperatures. We have also changed the structure of the walls by embedding soft ellipses in them, this change increases the total density near the wall whereas, increasing or decreasing the order parameter depend on the angle of embedded ellipses.

  19. Small hydro project in Wohlen, Bern - Preliminary study; Programm Kleinwasserkraftwerke. KWKW Hofenmuehle, Wohlen BE - Vorstudie

    Energy Technology Data Exchange (ETDEWEB)

    Fritschi, M.; Spescha, P.

    2008-11-15

    This report for the Swiss Federal Office of Energy (SFOE) presents the preliminary project study for the refurbishment of an existing small hydropower installation in Wohlen, Bern, Switzerland. The installation is in the Hofenmuehle, a listed mill complex dating from the first half of the nineteenth century. The headrace channel has already been refurbished by a community service group. The high level of financial effort and the idealism of the owner families are noted. The existing installations are described in detail. The refurbishment of the technical equipment and the associated work such as water-flow measurements are discussed. Cost estimates and environmental aspects are presented and discussed as are the financing of the refurbishment work and the cost-covering remuneration for the power produced. A possible increase in the power produced and the associated water-usage concession are discussed.

  20. Auger electron-emitting "1"1"1In-DTPA-NLS-CSL360 radioimmunoconjugates are cytotoxic to human acute myeloid leukemia (AML) cells displaying the CD123"+/CD131"− phenotype of leukemia stem cells

    International Nuclear Information System (INIS)

    Gao, Catherine; Leyton, Jeffrey V.; Schimmer, Aaron D.; Minden, Mark; Reilly, Raymond M.

    2016-01-01

    Chimeric IgG_1 monoclonal antibody CSL360 recognizes the CD123"+/CD131"− phenotype expressed by leukemic stem cells (LSC). Auger electron-emitting "1"1"1In-DTPA-NLS-CSL360 radioimmunoconjugates incorporating nuclear translocation sequence (NLS) peptides bound specifically to Raji cells transfected with CD123 and exhibited a K_D of 11 nmols/L in a competition receptor-binding assay using CD123-transfected CHO cells. "1"1"1In-DTPA-NLS-CSL360 was bound, internalized and transported to the nucleus of human AML-5 myeloid leukemia cells. The clonogenic survival of AML-5 cells was reduced by "1"1"1In-DTPA-NLS-CSL360 up to 3.7-fold. Isotype control "1"1"1In-DTPA-chIgG_1 was 2-fold less cytotoxic, and unlabeled CSL360, DTPA-NLS-CSL360 or free "1"1"1In acetate did not decrease cell survival. These results are promising for further evaluation of "1"1"1In-DTPA-NLS-CSL360 for Auger electron radioimmunotherapy of AML targeting the critical LSC subpopulation. - Highlights: • "1"1"1In-DTPA-NLS-CSL360 the CD123"+/CD131"− phenotype of leukemic stem cells (LSC). • "1"1"1In-DTPA-NLS-CSL360 was bound, internalized and imported into the nucleus of AML-5 leukemia cells. • "1"1"1In-DTPA-NLS-CSL360 reduced the clonogenic survival of AML-5 leukemia cells by 4-fold.

  1. The Effects of Wiki-Based Recursive Process Writing on Chinese Narrative Essays for Chinese as a Second Language (CSL) Students in Singapore

    Science.gov (United States)

    Chin, Chee Kuen; Gong, Cheng; Tay, Boon Pei

    2015-01-01

    This paper reports on the effects of using wiki-based process writing in Singapore's Chinese as a Second Language (CSL) scenarios. A group of 32 Secondary 1 (Seventh Grade) students ("Students") received various forms of online scaffolding at different steps of the writing process over two years. A whole set of teaching materials on 45…

  2. Effect of Corn Steep Liquor (CSL and Cassava Wastewater (CW on Chitin and Chitosan Production by Cunninghamella elegans and Their Physicochemical Characteristics and Cytotoxicity

    Directory of Open Access Journals (Sweden)

    Lúcia Raquel Ramos Berger

    2014-02-01

    Full Text Available Microbiological processes were used for chitin and chitosan production with Cunninghamella elegans UCP/WFCC 0542 grown in different concentrations of two agro-industrial wastes, corn steep liquor (CSL and cassava wastewater (CW established using a 22 full factorial design. The polysaccharides were extracted by alkali-acid treatment and characterized by infrared spectroscopy, viscosity, thermal analysis, elemental analysis, scanning electron microscopy and X-ray diffraction. The cytotoxicity of chitosan was evaluated for signs of vascular change on the chorioallantoic membrane of chicken eggs. The highest biomass (9.93 g/L was obtained in trial 3 (5% CW, 8% CSL, the greatest chitin and chitosan yields were 89.39 mg/g and 57.82 mg/g, respectively, and both were obtained in trial 2 (10% CW, 4% CSL. Chitin and chitosan showed a degree of deacetylation of 40.98% and 88.24%, and a crystalline index of 35.80% and 23.82%, respectively, and chitosan showed low molecular weight (LMW 5.2 × 103 Da. Chitin and chitosan can be considered non-irritating, due to the fact they do not promote vascular change. It was demonstrated that CSL and CW are effective renewable agroindustrial alternative substrates for the production of chitin and chitosan.

  3. Epstein-Barr virus nuclear protein 3C binds to the N-terminal (NTD) and beta trefoil domains (BTD) of RBP/CSL; Only the NTD interaction is essential for lymphoblastoid cell growth

    International Nuclear Information System (INIS)

    Calderwood, Michael A.; Lee, Sungwook; Holthaus, Amy M.; Blacklow, Stephen C.; Kieff, Elliott; Johannsen, Eric

    2011-01-01

    Association of EBV nuclear proteins EBNA2, EBNA3A and EBNA3C with RBP/CSL, is essential for lymphoblastoid cell line (LCL) proliferation. Conserved residues in the EBNA3 homology domain, required for RBP/CSL interaction, lack the WΦP motif that mediates EBNA2 and Notch binding to the RBP/CSL beta-trefoil domain (BTD). We map RBP/CSL interacting residues within EBNA3A(aa128-204) and EBNA3C(aa211-233). The EBNA3A results are consistent with an earlier report (aa125-222), but the EBNA3C domain is unexpectedly small and includes a 'WTP' sequence. This EBNA3C WTP motif confers RBP/CSL binding in vitro, in yeast, and in mammalian cells. Further, an EBNA3C WTP → STP(W227S) mutation impaired BTD binding whereas EBNA3 homology domain mutations disrupted RBP/CSL N-terminal domain (NTD) binding. WTP was not essential for EBNA3C repression of EBNA2 in reporter assays or for maintenance of LCL growth. Our results indicate that EBNA3 proteins interact with multiple RBP/CSL domains, but only NTD interactions are required for LCL growth.

  4. Benefit of Problem-Based Learning for Psychosocial Medicine: first experiences at the medical faculty of berne

    OpenAIRE

    Laederach-Hofmann, Kurt; Stadelmann, Barbara; Isenschmid, Bettina

    2005-01-01

    Aim: Presentation of skills and knowledge of medical students in psychiatry or psychosocial medicine in basic study (year 1 to 3) after the introduction of a problem oriented learning curriculum at the Medical Faculty of Berne.Method: Description of the curriculum with the different teaching units, and the evaluation by means of formative tools used by students and tutors.Results: With reference to qualitative comparison students of the problem based learning track showed a better preparation...

  5. Safety study of the Bio-10-SAD Bern strain of the rabies virus on the rhesus macaque monkey species

    Directory of Open Access Journals (Sweden)

    Vladimír Vrzal

    2013-01-01

    Full Text Available Based on a WHO recommendation, residual pathogenicity of the Bio-10-SAD Bern rabies virus strain (component of the Lysvulpen por. ad us. vet. vaccine was tested on rhesus macaque monkeys. Each of the ten monkeys, females, two years old, was administered orally 2 ml × 109 TCID50 of the Bio-10-SAD Bern rabies strain. The animals were monitored for 90 days. Subsequently, the animals were sacrificed and their brains were examined for presence of the vaccination rabies virus by the immunofluorescence and PCR methods. The occurrence of anti-rabies antibodies prior to and following administration of the vaccination rabies virus was also evaluated. No clinical signs of rabies were observed nor did any of the animals die of rabies following application of the virus. No rabies was detected in the study animals by post mortem examination. All of the 10 animals developed anti-rabies antibodies during the 90 days following administration of the rabies virus. It can be concluded, that Bio-10-SAD Bern virus administered at a dose equal to the tenfold maximum dose specified for field uses is safe to monkeys of the rhesus macaque species. This study is the first of its type performed in rhesus macaque monkey species.

  6. Effects of elongation on the phase behavior of the Gay-Berne fluid

    Science.gov (United States)

    Brown, Julian T.; Allen, Michael P.; Martín del Río, Elvira; Miguel, Enrique De

    1998-06-01

    In this paper we present a computer simulation study of the phase behavior of the Gay-Berne liquid crystal model, concentrating on the effects of varying the molecular elongation κ. We study a range of length-to-width parameters 3moves to lower temperature until it falls below the I-SB coexistence line, around κ=3.4, where liquid-vapor coexistence proves hard to establish. The liquid-vapor critical point seems to be completely absent at κ=4.0. Another dramatic effect is the growth of a stable SA ``island'' in the phase diagram at elongations slightly above κ=3.0. The SA range extends to both higher and lower temperatures as κ is increased. Also as κ is increased, the I-N transition is seen to move to lower density (and pressure) at given temperature. The lowest temperature at which the nematic phase is stable does not vary dramatically with κ. On cooling, no SB-crystal transition can be identified in the equation of state for any of these elongations; we suggest that, on the basis of simulation evidence, SB and crystal are really the same phase for these models.

  7. Molecular aspect ratio and anchoring strength effects in a confined Gay-Berne liquid crystal

    Science.gov (United States)

    Cañeda-Guzmán, E.; Moreno-Razo, J. A.; Díaz-Herrera, E.; Sambriski, E. J.

    2014-04-01

    Phase diagrams for Gay-Berne (GB) fluids were obtained from molecular dynamics simulations for GB(2, 5, 1, 2) (i.e. short mesogens) and GB(3, 5, 1, 2) (i.e. long mesogens), which yield isotropic, nematic, and smectic-B phases. The long-mesogen fluid also yields the smectic-A phase. Ordered phases of the long-mesogen fluid form at higher temperatures and lower densities when compared to those of the short-mesogen fluid. The effect of confinement under weak and strong substrate couplings in slab geometry was investigated. Compared to the bulk, the isotropic-nematic transition does not shift in temprature significantly for the weakly coupled substrate in either mesogen fluid. However, the strongly coupled substrate shifts the transition to lower temperature. Confinement induces marked stratification in the short-mesogen fluid. This effect diminishes with distance from the substrate, yielding bulk-like behaviour in the slab central region. Fluid stratification is very weak for the long-mesogen fluid, but the strongly coupled substrate induces 'smectisation', an ordering effect that decays with distance. Orientation of the fluid on the substrate depends on the mesogen. There is no preferred orientation in a plane parallel to the substrate for the weakly coupled case. In the strongly coupled case, the mesogen orientation mimics that of adjacent fluid layers. Planar anchoring is observed with a broad distribution of orientations in the weakly coupled case. In the strongly coupled case, the distribution leans toward planar orientations for the short-mesogen fluid, while a marginal preference for tilting persists in the long-mesogen fluid.

  8. [{sup 11}C]S.L.(25.1188), a new radioligand to study the monoamine oxidase type B with PET: preclinical characterisation

    Energy Technology Data Exchange (ETDEWEB)

    Saba, W.; Valette, H.; Peyronneau, M.A.; Bramoulle, Y.; Coulon, C.; Dolle, F.; Bottlaender, M. [Service Hospitalier Frederic Joliot, IIBM/DSV, 91 - Orsay (France); Curet, O.; George, P. [Sanofi-Aventis, 92 - Bagneux (France)

    2008-02-15

    Introduction. - Monoamine oxidase (M.A.O.) is a flavin containing enzyme, that catalyzes the oxidative deamination of various amines and neurotransmitters. Two isoforms exist, M.A.O.-A and M.A.O.-B. Variations in M.A.O. activity may be associated to human disease such as Parkinson and Alzheimer disease. Few radiotracers have been developed for M.A.O. PET studies such as [{sup 11}C]deprenyl, an irreversible M.A.O.-B inhibitor. Recently an oxazolidinone derivative, S.L.- 25.1188 ((S)-5-methoxy-methyl-3-[6-(4,4,4-tri-fluoro butoxy)- benzo[d]isoxazol-3-yl]-oxazolidin-2-one), belonging to a new generation of selective and reversible M.A.O.-B inhibitors was developed and showed in vitro a high selectivity for M.A.O.B. [1]. The aim of this study was to characterize [{sup 11}C]S.L.- 25.1188 as radioligand for in vivo PET examination of M.A.O.-B. Materials and methods. - PET studies of the brain distribution were carried out in male Papio anubis baboons. Selectivity and reversibility of [{sup 11}C]S.L.-25.1188 binding for M.A.O.-B was assessed by pre-treatment or displacement experiments (30 min before and after tracer injection, respectively) using reference ligands for M.A.O.-B (deprenyl: 2 mg/kg i.v. and lazabemide: 0.5 mg/kg i.v.) or by displacement experiments using unlabelled S.L.-25.1188 (1 mg/kg, i.v., 30 min after tracer injection). Distribution volume (D.V.) was calculated using 2-tissue-compartment model. The saturable binding following pre-treatment with deprenyl was considered as the specific binding. Results. - After injection, [1{sup 1C}]S.L.-25.1188 presents a rapid phase of distribution in blood (about 5 min), followed by a elimination with T1/2 of 75 min. The Blood to plasma concentration ratio was constant during the experimentation (0.9 {+-} .04) consistent with a similar kinetic of [{sup 11}C]S.L.- 25.1188 in both blood and plasma. Metabolism analysis showed that [{sup 11}C]S.L.-25.1188 is stable in vivo. In the brain, uptake in different areas was

  9. Cbf11 and Cbf12, the fission yeast CSL proteins, play opposing roles in cell adhesion and coordination of cell and nuclear division

    Czech Academy of Sciences Publication Activity Database

    Převorovský, M.; Groušl, Tomáš; Staňurová, J.; Ryneš, J.; Nellen, W.; Půta, F.; Folk, P.

    2009-01-01

    Roč. 315, č. 8 (2009), s. 1533-1547 ISSN 0014-4827 R&D Projects: GA ČR(CZ) GD204/03/H066 Grant - others:UK(CZ) 157/2005/B-BIO/PrF Institutional research plan: CEZ:AV0Z50200510 Keywords : csl family * fission yeast * adhesion Subject RIV: EE - Microbiology, Virology Impact factor: 3.589, year: 2009

  10. Standortbasierte Online-Informationen vermitteln: cUBe, ein Projekt der Universitätsbibliothek Bern

    Directory of Open Access Journals (Sweden)

    Reto List

    2017-12-01

    Full Text Available Die Transformation der Bibliotheksangebote schreitet immer weiter voran. In vielen Bibliotheken wird der sichtbare Buchbestand mehr und mehr von Arbeitsplätzen und Gruppenräumen verdrängt, Bibliotheken unterliegen zunehmend Neudefinitionen unter dem Label von Lern- und Begegnungsorten. Daneben nimmt die Bedeutung von elektronischen Medienangeboten und webbasierten Dienstleistungen laufend zu. Gleichzeitig ist das umfangreiche elektronische Angebot, welches Bibliotheken teuer lizensieren oder kaufen, oft nicht in aller Breite und zielgruppenbezogen bekannt und erfährt keine adäquate Nutzung. Mit dem Projekt cUBe wurde in der im Frühsommer 2016 nach umfangreicher Sanierung neu eröffneten Bibliothek Münstergasse der Universitätsbibliothek Bern der Versuch unternommen, die reichhaltigen digitalen Nachweise und Bestände für das Bibliothekspublikum sichtbarer, besser zugänglich und damit bekannter zu machen. Dabei wurde auf Basis der neuen Technologien des physischen Webs die standortbasierte Verbindung von OnlineInformationen (Katalog, E-Medien, sonstige digitale Angebote mit den entsprechenden Räumen der Bibliothek und den vor Ort noch verfügbaren Beständen realisiert. The transformation of library services is constantly proceeding. In many libraries, print collections are replaced by space designated to learning. Increasingly, our libraries are defined by labels like learning or meeting space. In addition, the importance of electronic collections and web-based services is constantly growing. However, this extensive and expensive electronic material licenced or bought by libraries is often neither known in detail and to all target groups nor used appropriately. The project cUBe was launched in late spring 2016 after an extensive renovation of the newly opened Münstergasse Library. cUBe aims at improving visibility, access and publicity of the library’s comprehensive digital references and collections for its users. On the basis of

  11. Attitude towards and Readiness for Interprofessional Education in Medical and Nursing Students of Bern

    Directory of Open Access Journals (Sweden)

    Woermann, Ulrich

    2016-11-01

    Full Text Available Objectives: Interprofessional collaboration is becoming increasingly important in health care for various reasons. Interprofessional Education (IPE can provide a basis for this.The aim of our study was to find out how medical (MS and nursing students (NS think about their own and other professions, what they know about each other, how strong their willingness to embrace IPE is, and what forms of IPE they deem useful.Methodology: Seven IPE experts rated the two measuring instruments, Readiness for Interprofessional Learning Scale RIPLS, and Interdisciplinary Education Perception Scale IEPS in terms of relevance of the items, and the quality of translation into German. Nine RIPLS items and 13 IEPS items were considered content-valid. All MS of the University of Bern and NS of the two Bernese educational institutions for nursing were invited to the online survey in the fall of 2014 by email. Results: 498 (254 MS, 244 NS of the 2374 invited students completely filled in the questionnaire (21%.The results of the reduced RIPLS allowed no conclusive statements. When assessing their own occupational group in the IEPS, the MS attributed "competence and autonomy" to themselves significantly more frequently, while to the NS, the same was true for the item, "actual cooperation". MS know significantly less about the training of other health professionals. NS show a significantly higher willingness to embrace IPE. Teaching ethics, communication, team training, and clinical skills are deemed suitable for IPE by both groups. From the comments it appears that in both groups a majority welcomes IPE; however, the various arguments had different prevalence in both groups. Both groups fear that IPE leads to heightened stress during the study. A subgroup of MS fears a lowering of academic level. Conclusion: The results of this survey of Bernese MS and NS concerning IPE provide important information for the planning and implementation of IPE. Important steps in the

  12. Laparoscopic lateral pancreaticojejunostomy and laparoscopic Berne modification of Beger procedure for the treatment of chronic pancreatitis: the first UK experience.

    Science.gov (United States)

    Khaled, Yazan S; Ammori, Basil J

    2014-10-01

    Pancreatic resection and/or ductal drainage are common surgical options in the management of unremitting abdominal pain of chronic pancreatitis (CP). We describe the results of the largest UK series of laparoscopic approach to pancreatic duct drainage and head resection for CP. Patients with CP and intractable abdominal pain requiring duodenum-preserving pancreatic head resection (Berne modification of Beger procedure) or Puestow procedure were offered laparoscopic surgery by a single surgeon. The results shown represent median (range). Six patients (3 males) with CP (alcohol induced, n=4; idiopathic, n=2) underwent surgery between 2009 and 2012. The pancreatic duct diameter was 8.75 (6 to 11) mm. Five patients have had lateral pancreaticojejunostomy and 1 patient underwent Berne modification of Beger procedure, all of which were completed laparoscopically. The operating time was 277.5 (250 to 360) minutes. There were no deaths and 1 patient was readmitted 10 days postoperatively and had laparotomy for pancreatic bleeding after pancreaticojejunostomy (morbidity, 17%). The hospital stay was 5 (5 to 8) days. At a follow-up of 14.2 (10 to 35) months, 4 of the patients were pain free, whereas 2 patients required one third and half of the preoperative oral opioid dose for pain control. The laparoscopic approach to pancreatic duct drainage and duodenum-preserving head resection in carefully selected patients and in experienced hands is feasible and safe with good short-term results and potential advantages. Further expansion of experience and longer follow-up is required.

  13. The Effects of Wiki-based Recursive Process Writing on Chinese Narrative Essays for Chinese as a Second Language (CSL Students in Singapore

    Directory of Open Access Journals (Sweden)

    Chee Kuen Chin

    2015-01-01

    Full Text Available This paper reports on the effects of using wiki-based process writing in Singapore’s Chinese as a Second Language (CSL scenarios. A group of 32 Secondary 1 (Seventh Grade students (“Students” received various forms of online scaffolding at different steps of the writing process over two years. A whole set of teaching materials on 45 writing skills was developed and uploaded to the Wiki platform through five recursive cycles. In each cycle, the students were encouraged to apply skills they learned via Wiki platform in their writing and afterwards work as a team in the platform to peer-review each other’s first draft. With feedback received from peer revision, students proceeded to edit their first draft, focusing on the content of narratives and the appropriateness on their use of micro writing skills. The scaffolding decreased as the project progressed. Students’ pre-, mid- and post-writing tests were marked and compared. The authors analyzed the impact that the feedback in the process had towards the students’ overall writing performance. It was discovered that students' quality of written products was improved in general. It was also discovered that students benefited the most from giving remarks to their peers’ writing. The revision patterns of high, medium and low language ability students were also compared. It was found that the higher the language ability of the students, the more concerned they were with macro level for their revisions. ICT-mediated process writing has not garnered much attention in the field of CSL. The study hopes to contribute to the literature of ICTmediated writing instruction in the field of CSL.

  14. Yeast RNA viruses as indicators of exosome activity: human exosome hCsl4p participates in RNA degradation in Saccharomyces cerevisiae'.

    Science.gov (United States)

    Ramírez-Garrastacho, Manuel; Esteban, Rosa

    2011-12-01

    The exosome is an evolutionarily conserved 10-mer complex involved in RNA metabolism, located in both the nucleus and the cytoplasm. The cytoplasmic exosome plays an important role in mRNA turnover through its 3'→5' exonucleolytic activity. The superkiller (SKI) phenotype of yeast was originally identified as an increase of killer toxin production due to elevated levels of the L-A double-stranded RNA (dsRNA) Totivirus and its satellite toxin-encoding M dsRNA. Most SKI genes were later shown to be either components of the exosome or modulators of its activity. Variations in the amount of Totivirus are, thus, good indicators of yeast exosome activity, and can be used to analyse its components. Furthermore, if exosome proteins of higher eukaryotes were functional in S. cerevisiae, these viruses would provide a simple tool to analyse their function. In this work, we have found that hCSL4, the human orthologue of SKI4 in the yeast exosome, rescues the null phenotype of the deletion mutant. hCsl4p shares with Ski4p conserved S1 RNA-binding domains, but lacks the N-terminal third of Ski4p. Nevertheless, it interacts with the Dis3p exonuclease of yeast exosome, and partially complements the superkiller phenotype of ski4-1 mutation. The elimination of the N-terminal third of Ski4p does not affect its activity, indicating that it is dispensable for RNA degradation. We have also identified the point mutation G152E in hCSL4, equivalent to the ski4-1 mutation G253E, which impairs the activity of the protein, thus validating our approach of using yeast RNA virus to analyse the exosome of higher eukaryotes. Copyright © 2011 John Wiley & Sons, Ltd.

  15. Effect of dietary supplementation with Lactobacillus acidophilus D2/CSL (CECT 4529) on caecum microbioma and productive performance in broiler chickens

    OpenAIRE

    De Cesare, Alessandra; Sirri, Federico; Manfreda, Gerardo; Moniaci, Paola; Giardini, Alberto; Zampiga, Marco; Meluzzi, Adele

    2017-01-01

    This study examines the effects of the dietary supplementation with Lactobacillus acidophilus D2/CSL (CECT 4529) (LA) on productive performances, incidence of foot pad dermatitis and caecum microbioma in broiler chickens. A total of 1,100 one-day old male Ross 308 chicks were divided into 2 groups of 16 replicates with 25 birds each and reared from 1-41 d. One group was fed a basal diet (CON) and the other group the same diet supplemented with LA. Caecum contents were collected from 4 selecte...

  16. 2016 Consensus statement on return to sport from the First World Congress in Sports Physical Therapy, Bern

    DEFF Research Database (Denmark)

    Ardern, Clare L; Glasgow, Philip; Schneiders, Anthony

    2016-01-01

    evidence to make recommendations for return to sport decision-making, clinical practice and future research directions related to returning athletes to sport. A half day meeting was held in Bern, Switzerland, after the First World Congress in Sports Physical Therapy. 17 expert clinicians participated. 4...... sense of individual factors that may influence the athlete's return to sport, and the Strategic Assessment of Risk and Risk Tolerance framework may help decision-makers synthesise information to make an optimal return to sport decision. Research evidence to support return to sport decisions in clinical...... practice is scarce. Future research should focus on a standardised approach to defining, measuring and reporting return to sport outcomes, and identifying valuable prognostic factors for returning to sport....

  17. Temperature-dependent study of isotropic-nematic transition for a Gay-Berne fluid using density-functional theory

    International Nuclear Information System (INIS)

    Singh, Ram Chandra

    2007-01-01

    We have used the density-functional theory to study the effect of varying temperature on the isotropic-nematic transition of a fluid of molecules interacting via the Gay-Berne intermolecular potential. The nematic phase is found to be stable with respect to isotropic phase in the temperature range 0.80≤T*≤1.25. Pair correlation functions needed as input information in density-functional theory is calculated using the Percus-Yevick integral equation theory. We find that the density-functional theory is good for studying the isotropic-nematic transition in molecular fluids if the values of the pair-correlation functions in the isotropic phase are known accurately. We have also compared our results with computer simulation results wherever they are available

  18. The introduction of gas-powered busses in Berne; Die Einfuehrung von Gasbussen bei Bernmobil - Ein Erfahrungsbericht

    Energy Technology Data Exchange (ETDEWEB)

    Finger, D.; Kljun, N.; Keller, M.

    2008-07-01

    This report for the Swiss Federal Office of Energy (SFOE) discusses the experience gained from the operation of biogas-powered buses in Berne, Switzerland. The fleet conversion from diesel-engined buses to new vehicles powered by biogas from the city's wastewater treatment plant is discussed. Six operational aspects involved in the use of gas-powered buses in comparison with traditional diesel buses are examined and discussed. These include infrastructure adaptations, fuel and energy consumption, emissions and air-hygiene, operational changes, financial aspects and acceptance of the new vehicles both by operating personnel and the general public. Operational difficulties encountered after fire-damage to the gas filling equipment in the bus depot are noted. Fuel consumption is commented on and measurements made on emissions are discussed. The advantages and disadvantages of biogas busses in comparison with diesel busses are discussed.

  19. Glass Formation of n-Butanol: Coarse-grained Molecular Dynamics Simulations Using Gay-Berne Potential Model

    Science.gov (United States)

    Xie, Gui-long; Zhang, Yong-hong; Huang, Shi-ping

    2012-04-01

    Using coarse-grained molecular dynamics simulations based on Gay-Berne potential model, we have simulated the cooling process of liquid n-butanol. A new set of GB parameters are obtained by fitting the results of density functional theory calculations. The simulations are carried out in the range of 290-50 K with temperature decrements of 10 K. The cooling characteristics are determined on the basis of the variations of the density, the potential energy and orientational order parameter with temperature, whose slopes all show discontinuity. Both the radial distribution function curves and the second-rank orientational correlation function curves exhibit splitting in the second peak. Using the discontinuous change of these thermodynamic and structure properties, we obtain the glass transition at an estimate of temperature Tg=120±10 K, which is in good agreement with experimental results 110±1 K.

  20. BERN railway station: security assessment under a speed increase of trains from 30 to 40 km h-1

    International Nuclear Information System (INIS)

    Ribaux, C.; Capron, M.

    1994-01-01

    In the frame of the ''Rail 2000'' project, the CFF (Swiss Railways) would like to increase the speed of trains arriving in Bern station. On the eastern head, this speed would be raised from 30 to 40kmh -1 . The superstructure is formed by a three-storey building which rests on 450mm diameter steel columns.The aim of the present study was: - to determine the security loss of the station superstructure under a train impact on the columns at 40kmh -1 rather than at 30kmh -1 - to propose measures in order to get at 40kmh -1 the same security as at 30kmh -1 Four approaches are dealt with: (1)on the base of accidents statistics and of their cost; (2)review of possible dynamical approaches; (3)equivalent static load (from European railways codes); (4)energy in which, starting from its initial speed, the train loses energy on different obstacles (ballast, platform, protection devices, walls, train's own deformation) and the remaining energy is compared with the maximum energy that the column can dissipate by deformation.The conclusions are presented as a 'security plan' and the proposed protection costs are evaluated. ((orig.))

  1. A 3'-coterminal nested set of independently transcribed mRNAs is generated during Berne virus replication

    International Nuclear Information System (INIS)

    Snijder, E.J.; Horzinek, M.C.; Spaan, W.J.

    1990-01-01

    By using poly(A)-selected RNA from Berne virus (BEV)-infected embryonic mule skin cells as a template, cDNA was prepared and cloned in plasmid pUC9. Recombinants covering a contiguous sequence of about 10 kilobases were identified. Northern (RNA) blot hybridizations with various restriction fragments from these clones showed that the five BEV mRNAs formed a 3'-coterminal nested set. Sequence analysis revealed the presence of four complete open reading frames of 4743, 699, 426, and 480 nucleotides, with initiation codons coinciding with the 5' ends of BEV RNAs 2 through 5, respectively. By using primer extension analysis and oligonucleotide hybridizations, RNA 5 was found to be contiguous on the consensus sequence. The transcription of BEV mRNAs was studied by means of UV mapping. BEV RNAs 1, 2, and 3 were shown to be transcribed independently, which is also likely--although not rigorously proven--for RNAs 4 and 5. Upstream of the AUG codon of each open reading frame a conserved sequence pattern was observed which is postulated to function as a core promoter sequence in subgenomic RNA transcription. In the area surrounding the core promoter region of the two most abundant subgenomic BEV RNAs, a number of homologous sequence motifs were identified

  2. A study of isotropic-nematic transition of quadrupolar Gay-Berne fluid using density-functional theory approach

    Science.gov (United States)

    Singh, Ram Chandra; Ram, Jokhan

    2011-11-01

    The effects of quadrupole moments on the isotropic-nematic (IN) phase transitions are studied using the density-functional theory (DFT) for a Gay-Berne (GB) fluid for a range of length-to-breadth parameters ? in the reduced temperature range ? . The pair-correlation functions of the isotropic phase, which enter into the DFT as input parameters are found by solving the Percus-Yevick integral equation theory. The method used involves an expansion of angle-dependent functions appearing in the integral equations in terms of spherical harmonics and the harmonic coefficients are obtained by an iterative algorithm. All the terms of harmonic coefficients which involve l indices up to less than or equal to 6 are considered. The numerical accuracy of the results depends on the number of spherical harmonic coefficients considered for each orientation-dependent function. As the length-to-breadth ratio of quadrupolar GB molecules is increased, the IN transition is seen to move to lower density (and pressure) at a given temperature. It has been observed that the DFT is good to study the IN transitions in such fluids. The theoretical results have also been compared with the computer simulation results wherever they are available.

  3. Trends and Weekly Cycles in a Large Swiss Emergency Centre: A 10 Year Period at the University Hospital of Bern

    Directory of Open Access Journals (Sweden)

    Christian T. Braun

    2017-10-01

    Full Text Available Popular demand for high quality care has increased in recent years. This is also the case for medical services and support at all times of the day and night is nowadays required. During the last ten years, there has been a marked increase in the demands on hospital emergency hospitals, particularly in the Western industrialized countries. The present retrospective study investigates how the demands on a large Swiss university centre have changed over a period of 10 years. Patient numbers are differentiated by age, gender, nationality, weekday and mode of referral. A retrospective analysis was performed of the data of the patients admitted to the Emergency Centre of Bern University Medical Hospital (Inselspital during the ten-year period from 2004 up to and including 2013 and who were treated as emergencies. A total of 264,272 patients were included in the study. It was shown that there was an uninterrupted annual increase from 23,555 patients in 2004 to 34,918 patients in 2013 (+48%. Most patients came to the Emergency Centre on Mondays, followed by Fridays. Because of the marked increase in life expectancy and the resulting demographic changes, there has been a marked increase in the number of older patients coming to the Emergency Centre for acute medical care. It was found that there were disproportionately high numbers of patients aged 20 to 49 years who were not Swiss citizens. In contrast, most patients over 60 were Swiss. In the coming years, emergency centres will have to adapt to the continued increase in patient numbers. This trend will continue, so that it is essential to consider the sociodemographic structure of a region when planning the availability of emergency medical care.

  4. Benefit of Problem-Based Learning for Psychosocial Medicine: first experiences at the medical faculty of berne

    Directory of Open Access Journals (Sweden)

    Laederach-Hofmann, Kurt

    2005-04-01

    Full Text Available Aim: Presentation of skills and knowledge of medical students in psychiatry or psychosocial medicine in basic study (year 1 to 3 after the introduction of a problem oriented learning curriculum at the Medical Faculty of Berne.Method: Description of the curriculum with the different teaching units, and the evaluation by means of formative tools used by students and tutors.Results: With reference to qualitative comparison students of the problem based learning track showed a better preparation of the different teaching units than did traditional students. Moreover, compared to classical teaching, students in problem based learning rated the commitment of the teachers higher. The formative results showed a better adherence to the teaching modules, a higher effort in self learning and a higher interest in psychological or psychiatric learning items.Discussion: The higher commitment of teachers and the explicit structuring of the teaching contents in psychiatry and psychosocial medicine showed positive effects in the learning strategy of students. Beside the fact that exams have been adapted to the new curriculum one can assume that the learning style has changed. This might be a result of the better learning environment in the new curriculum. However, there is not clear how and to what extent these changes will remain active until the final exams of the medical curriculum when psychosocial contents will be reexamined.Conclusions: The intense commitment of the teachers and the better structuring of the subject matter may lead to a better integration of psychosocial and psychiatric issues into the medical curriculum.

  5. 2016 Consensus statement on return to sport from the First World Congress in Sports Physical Therapy, Bern.

    Science.gov (United States)

    Ardern, Clare L; Glasgow, Philip; Schneiders, Anthony; Witvrouw, Erik; Clarsen, Benjamin; Cools, Ann; Gojanovic, Boris; Griffin, Steffan; Khan, Karim M; Moksnes, Håvard; Mutch, Stephen A; Phillips, Nicola; Reurink, Gustaaf; Sadler, Robin; Silbernagel, Karin Grävare; Thorborg, Kristian; Wangensteen, Arnlaug; Wilk, Kevin E; Bizzini, Mario

    2016-07-01

    Deciding when to return to sport after injury is complex and multifactorial-an exercise in risk management. Return to sport decisions are made every day by clinicians, athletes and coaches, ideally in a collaborative way. The purpose of this consensus statement was to present and synthesise current evidence to make recommendations for return to sport decision-making, clinical practice and future research directions related to returning athletes to sport. A half day meeting was held in Bern, Switzerland, after the First World Congress in Sports Physical Therapy. 17 expert clinicians participated. 4 main sections were initially agreed upon, then participants elected to join 1 of the 4 groups-each group focused on 1 section of the consensus statement. Participants in each group discussed and summarised the key issues for their section before the 17-member group met again for discussion to reach consensus on the content of the 4 sections. Return to sport is not a decision taken in isolation at the end of the recovery and rehabilitation process. Instead, return to sport should be viewed as a continuum, paralleled with recovery and rehabilitation. Biopsychosocial models may help the clinician make sense of individual factors that may influence the athlete's return to sport, and the Strategic Assessment of Risk and Risk Tolerance framework may help decision-makers synthesise information to make an optimal return to sport decision. Research evidence to support return to sport decisions in clinical practice is scarce. Future research should focus on a standardised approach to defining, measuring and reporting return to sport outcomes, and identifying valuable prognostic factors for returning to sport. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  6. Paradoxical effects of Auger electron-emitting 111In-DTPA-NLS-CSL360 radioimmunoconjugates on hCD45+ cells in the bone marrow and spleen of leukemia-engrafted NOD/SCID or NRG mice

    International Nuclear Information System (INIS)

    Bergstrom, Dane; Leyton, Jeffrey V.; Zereshkian, Arman; Chan, Conrad; Cai, Zhongli; Reilly, Raymond M.

    2016-01-01

    Introduction: 111 In-DTPA-NLS-CSL360 radioimmunoconjugates (RIC) recognize the overexpression of the interleukin-3 receptor α-subchain (CD123) relative to the β-subchain (CD131) on leukemia stem cells (LSC). Our aim was to study Auger electron radioimmunotherapy (RIT) of acute myeloid leukemia (AML) with 111 In-DTPA-NLS-CSL360 in non-obese diabetic severe combined immunodeficiency (NOD/SCID) mice or NOD-Rag1 null IL2rγ null (NRG) mice engrafted with CD123 + human AML-5 cells. Methods: The toxicity of three doses of 111 In-DTPA-NLS-CSL360 (3.3–4.8 MBq; 11–15 μg each) injected i.v. every two weeks was studied in non-engrafted NOD/SCID or NRG mice pre-treated with 200 cGy of γ-radiation required for AML engraftment. Engraftment efficiency of (1–5) × 10 6 cells AML-5 cells inoculated i.v. into NOD/SCID or NRG mice was assessed by flow cytometric analysis for human CD45 + (hCD45 + ) cells in the bone marrow (BM) and spleen. AML-5 engrafted mice were treated with two or three doses (3.7 MBq; 10 μg each) every two weeks of 111 In-DTPA-NLS-CSL360, non-specific 111 In-DTPA-NLS-hIgG, unlabeled CSL360 (10 μg) or normal saline. The percentage of hCD45 + cells in the BM and spleen were measured at one week after completion of treatment. Results: 111 In-DTPA-NLS-CSL360 in combination with 200 cGy of γ-radiation caused an initial transient decrease in body weight in NOD/SCID but not in NRG mice. There were no hematological, liver or kidney toxicities. The spleen exhibited 13-fold lower engraftment efficiency than the BM in NOD/SCID mice inoculated with 1 × 10 6 cells but both organs were highly (>85%) engrafted in NRG mice. Unexpectedly, 111 In-DTPA-NLS-CSL360 or non-specific 111 In-DTPA-NLS-hIgG caused a paradoxical 1.5-fold increase (P < 0.0001) in the proportion of hCD45 + cells in the BM of NOD/SCID mice compared to normal saline treated mice. 111 In-DTPA-NLS-CSL360 reduced hCD45 + cells in the spleen by 3.0-fold compared to 111 In-DTPA-NLS-hIgG (P = 0

  7. Popis šablony ČSN ISO 690:2011 v jazyce CSL pro citační manažer Zotero

    OpenAIRE

    Ansorge Libor; Kratochvíl Jiří

    2013-01-01

    Necitování zdrojů použitých ve vlastní práci je považováno za porušení citační etiky a především je v rozporu s autorským zákonem. Ve světě existuje řada citačních stylů, jejichž množství se odvíjí od různých požadavků jednotlivých vydavatelů. V takovéto situaci autorům usnadňují citování různé citační manažery, z nichž některé využívají jazyk Citation Style Language (CSL). Jedním z nich je i aplikace Zotero, pro kterou je v současnosti optimalizována šablona citační normy ČSN ISO 690, jež je...

  8. Bern Power Station Co

    International Nuclear Information System (INIS)

    1981-01-01

    The Bernische Kraftwerke electricity generation/supply company supplies about one eighth of the Swiss electrical energy demand with about one sixth of the Swiss generating capacity. Directly or indirectly one million inhabitants are supplied, a substantial contribution to the Swiss economy. Data given on BKW includes: historical background, structure, organisation, operations, generating plant, transmission/distribution equipment, electricity generated, supplied, exported and imported, financial aspects, accounting practice and cooperation arrangements with other utilities. (P.G.R.)

  9. Effect of dietary supplementation with Lactobacillus acidophilus D2/CSL (CECT 4529 on caecum microbioma and productive performance in broiler chickens.

    Directory of Open Access Journals (Sweden)

    Alessandra De Cesare

    Full Text Available This study examines the effects of the dietary supplementation with Lactobacillus acidophilus D2/CSL (CECT 4529 (LA on productive performances, incidence of foot pad dermatitis and caecum microbioma in broiler chickens. A total of 1,100 one-day old male Ross 308 chicks were divided into 2 groups of 16 replicates with 25 birds each and reared from 1-41 d. One group was fed a basal diet (CON and the other group the same diet supplemented with LA. Caecum contents were collected from 4 selected birds at day one and 5 selected birds at the end of the rearing period. Then, they were submitted to DNA extraction and whole DNA shotgun metagenomic sequencing. Overall, the LA supplementation produced a significant beneficial effect on body weight gain between 15-28 d and improved feed conversion rate in the overall period. On the contrary, litter moisture, pH and incidence of the foot pad lesions were not affected by LA. Birds treated with LA showed a lower occurrence of pasty vent at both 14 and 28 d. At the end of the rearing period, Lachanospiraceae were significantly higher in LA birds in comparison to CON (17.07 vs 14.39%; P = 0.036. Moreover, Ruminococcus obeum, Clostridium clostridioforme, Roseburia intestinalis, Lachnospiraceae bacterium 14-2T and Coprococcus eutactus were significantly higher in LA birds in comparison to CON. The relative abundance of Lactobacillus acidophilus was comparable between LA and CON groups. However, a positive effect was observed in relation to the metabolic functions in the treated group, with particular reference to the higher abundance of β-glucosidase. In conclusion, the LA supplementation improved broiler productive performances and metabolic functions promoting animal health.

  10. Effect of dietary supplementation with Lactobacillus acidophilus D2/CSL (CECT 4529) on caecum microbioma and productive performance in broiler chickens.

    Science.gov (United States)

    De Cesare, Alessandra; Sirri, Federico; Manfreda, Gerardo; Moniaci, Paola; Giardini, Alberto; Zampiga, Marco; Meluzzi, Adele

    2017-01-01

    This study examines the effects of the dietary supplementation with Lactobacillus acidophilus D2/CSL (CECT 4529) (LA) on productive performances, incidence of foot pad dermatitis and caecum microbioma in broiler chickens. A total of 1,100 one-day old male Ross 308 chicks were divided into 2 groups of 16 replicates with 25 birds each and reared from 1-41 d. One group was fed a basal diet (CON) and the other group the same diet supplemented with LA. Caecum contents were collected from 4 selected birds at day one and 5 selected birds at the end of the rearing period. Then, they were submitted to DNA extraction and whole DNA shotgun metagenomic sequencing. Overall, the LA supplementation produced a significant beneficial effect on body weight gain between 15-28 d and improved feed conversion rate in the overall period. On the contrary, litter moisture, pH and incidence of the foot pad lesions were not affected by LA. Birds treated with LA showed a lower occurrence of pasty vent at both 14 and 28 d. At the end of the rearing period, Lachanospiraceae were significantly higher in LA birds in comparison to CON (17.07 vs 14.39%; P = 0.036). Moreover, Ruminococcus obeum, Clostridium clostridioforme, Roseburia intestinalis, Lachnospiraceae bacterium 14-2T and Coprococcus eutactus were significantly higher in LA birds in comparison to CON. The relative abundance of Lactobacillus acidophilus was comparable between LA and CON groups. However, a positive effect was observed in relation to the metabolic functions in the treated group, with particular reference to the higher abundance of β-glucosidase. In conclusion, the LA supplementation improved broiler productive performances and metabolic functions promoting animal health.

  11. Modelling and mapping of spatial differentiated impacts of nitrogen input to ecosystems within the framework of the UNECE-Convention of Air Pollution Prevention. Part II. The model BERN - assessment of vegetation change and biodiversity; Modellierung und Kartierung raeumlich differenzierter Wirkungen von Stickstoffeintraegen in Oekosysteme im Rahmen der UNECE-Luftreinhaltekonvention. Teilbericht II. Das BERN-Modell - ein Bewertungsmodell fuer die oberirdische Biodiversitaet

    Energy Technology Data Exchange (ETDEWEB)

    Nagel, Hans-Dieter; Schlutow, Angela; Kraft, Philipp; Scheuschner, Thomas; Weigelt-Kirchner, Regine [OEKO-DATA - Ecosystem Analysis and Environmental Data Management, Strausberg (Germany)

    2010-03-15

    Semi-natural ecosystems are exposed to high atmospheric deposition for decades. In contrary to sulphur deposition which could be significantly reduced due to international conventions on air pollution prevention during the last decades, deposition of both, reduced and oxidized nitrogen is still on a very high level in average 40 kg N ha{sup -1} yr{sup -1} in forest ecosystems in Germany. The FuE-Project ''Modelling and mapping of spatial differentiated impacts of nitrogen input to ecosystems within the framework of the UNECE - Convention of Air Pollution Prevention'' was jointly conducted by 4 partner institutions and studied impacts of atmospheric nitrogen deposition and climate change on physicochemical properties of forest soils, nutrient storage and nutrient export (Karlsruhe Research Centre, IMK-IFU) as well as biodiversity of vegetation (OEKO-DATA and Waldkundeinstitut Eberswalde) and soil organisms (Giessen University). Work carried out at OEKO-DATA initially concentrated on the development of the BERN-model. About 14 585 vegetation inventories from all over Germany and other 2 914 relevant inventories evaluated from neighboring countries were integrated in BERN database. With this model, the vegetation changes as a function of variations in the location conditions could be identified due to the implementation of the corresponding time series of geochemical and climate parameters from MoBiLE. A validation of the MoBiLE-BERN-coupling was carried out at Level II sites. From the dynamics of the vegetation development in the context of location changes could be derived critical loads and limits. Also the current regeneration potential as well as a harmonious natural balance of location factors could be determined. Likewise, the potential of danger to biodiversity and the livelihood opportunities of plant species or societies could be demonstrated. The most distinct dependence of biodiversity change could be detected on the alterations of

  12. [Incidence and prevalence of disabled rheumatic patients. A socio-epidemiological study on the services of the disability insurance system in the canton of Berne].

    Science.gov (United States)

    Blatter, L A; Cloetta, B

    1985-06-01

    The incidence and prevalence of patients with musculoskeletal disorders benefiting from the Swiss invalidity insurance system in the Canton of Berne, Switzerland, are studied. During a 5-year period 1252 such patients (393 women) first received either payments or were supported by rehabilitation measures (incidence). The correlation of this incidence with sociodemographic factors such as sex, age, disease pattern, place of residence and occupation, as well as the type of service delivered, are analyzed and discussed. At a given date (March 1982) 2754 patients with musculoskeletal disorders were receiving insurance pension (prevalence). By relating these figures to census data (total population), a 1.37% 5-year benefit incidence and a 3.02% pension prevalence can be calculated.

  13. Computer simulation studies of anisotropic systems. XXXII. Field-induction of a smectic A phase in a Gay-Berne mesogen

    Science.gov (United States)

    Luckhurst, G. R.; Saielli, G.

    2000-03-01

    Molecular field theory predicts the induction of a smectic A phase by the application of a field, either magnetic or electric, to a nematic phase. This intriguing behavior results from an enhancement of the orientational order which is coupled to the translational order and so shifts the smectic A-nematic transition. To test this prediction we have investigated a system of Gay-Berne mesogenic molecules subject to an applied field of second rank using isothermal-isobaric Monte Carlo simulations. The results of our calculations are compared with the Kventsel-Luckhurst-Zewdie molecular field theory of smectogens, modified to include the effect of an external field. We have also used the simulations to explore the possibility of inducing more ordered smectic phases with stronger fields.

  14. [A million football fans in a city of 120,000 inhabitants--a nightmare for emergency medicine and disaster management? Euro 2008 and the "Orange wonder of Berne"].

    Science.gov (United States)

    Martinolli, L; Tanyeli, E; Hasler, R M; Burkhardt, P; Bähler, H; Neff, F; Rupp, P; Zimmermann, H; Exadaktylos, A K

    2011-01-01

    The 2008 European Football Championship 2008 (Euro 08) is the largest sporting event ever organized in Switzerland. One million visitors came to the city of Berne during the event and the local airport in Bern/Belp registered 261 extra flights. For each football game there were 33,000 fans in the stadium and 100,000 fans in the public viewing zones.The ambulance corps and the Department of Emergency Medicine (ED) at Inselspital, University Hospital Berne, were responsible for basic medical care and emergency medical management. Injuries and illnesses were analyzed by a standardized score (NACA score). The preparation strategy as well as costs and patient numbers are presented in detail.A total of 30 additional ambulance vehicles were used, 4,723 additional working days (one-third medical professionals) were accumulated, 662 ambulance calls were registered and 240 persons needed medical care (62% Swiss, 28% Dutch and 10% other nationalities). Among those needing treatment 51 were treated in 1 of the 4 city hospitals. No injuries with NACA grades VI and VII occurred (NACA I: 4, NACA II: 17, NACA III: 16, NACA IV: 10 and NACA V: 4 patients). The city of Berne compensated the Inselspital Bern with a total of 112,603 Euros for extra medical care costs. The largest amount was spent on security measures (50,300 Euros) and medical staff (medical doctors 22,600 Euros, nurses 29,000 Euros). Because of the poor weather and the exemplary behavior of the fans, the course of events was rather peaceful.

  15. Molecular dynamics simulation study on the phase behavior of the Gay-Berne model with a terminal dipole and a flexible tail

    International Nuclear Information System (INIS)

    Fukunaga, Hiroo; Takimoto, Jun-ichi; Doi, Masao

    2004-01-01

    To study the effect of the alkyl tail and the terminal dipole on the stability of the liquid crystalline phase of mesogens, we have carried out molecular dynamics simulations for 1CB(4-methyl-4 ' -cyanobiphenyl) and 5CB(4-n-pentyl-4 ' -cyanobiphenyl) by using a coarse-grained model. In the coarse-grained model, a 5CB molecule is divided into the rigid part of 1CB moiety, which is represented by an ellipsoid, and the remaining flexible part which is represented by a chain of united atoms. The nonbonded potential between coarse-grained segments is represented by the generalized Gay-Berne (GB) potential and the potential parameters are determined by directly comparing the GB potential with the atomistic potentials averaged over the rotation of the mesogen around its axis. In addition, a dipole moment is placed at one end of the ellipsoid opposite to the flexible tail. The ordered state obtained in the polar 5CB model was assigned as the nematic phase, and the experimental static and dynamical properties were reproduced well by using this coarse-grained model. Both the dipole-dipole interactions and the thermal fluctuation of the flexible tail increase the positional disorder in the director direction, and stabilize the nematic phase. Thus, the nematic phase in the polar 5CB is induced by a cooperative effect of the flexible tail and the terminal dipole. It is noted that a local bilayer structure with head-to-head association is formed in the nematic phase, as experimentally observed by x-ray diffraction measurements

  16. ¿Qué hacer con el ángel? J. L. Borges y F. L. Bernárdez, dos formas de escribir la experiencia mística

    Directory of Open Access Journals (Sweden)

    Lucas Adur

    2015-06-01

    Full Text Available Este trabajo propone una lectura de dos textos de escritores argentinos, publicados casi contemporáneamente, El buque (1935 de Francisco Luis Bernárdez y “El acercamiento a Almotásim” (1936 de Jorge Luis Borges, que pueden considerarse como dos modos, diametralmente opuestos, de dar cuenta de una experiencia mística. Una “positiva”, que apuesta por un discurso conceptual y una “negativa” que opta por la alusión, la paradoja y el silencio. El poema de Bernárdez tiene en su centro una revelación mística, experimentada por el yo lírico, que es transmisible en términos discursivos y que implica una propuesta moral. En este sentido, puede pensarse que El buque es representativo de la estética sostenida por un grupo de poetas católicos que, apoyados en la teología escolástica, proponían que la literatura debía estar al servicio de la difusión del mensaje cristiano y del renacimiento espiritual del pueblo. Borges escribe una reseña de este poema y, meses después, “El acercamiento a Almotásim”, relato que puede leerse como una respuesta polémica a la forma de presentar la experiencia mística que propone el texto de Bernárdez. Frente al “decir excesivo” que atribuye al poeta católico, Borges subraya en su escritura la dimensión inefable, intransmisible que caracteriza para él a toda experiencia directa de lo trascendente.

  17. BKW-FMB: Focus on solar power; In Topform: die BKW FMB Energie AG - Mitten in Bern: Sonnenstrom im Fokus - In Partnerschaft mit der Juvent SA: viel Wind im Jura - Wasserkraft Aarberg: Wasserkraft - oekologisch zertifiziert

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    This collection of three short articles present four examples of installations using renewable forms of energy that are operated by the Bernese power utility BKW-FMB in Switzerland. Brief details are given on the company, one of the largest electricity utilities in Switzerland. The first article deals with the photovoltaics (PV) installations on the roof of the new national soccer stadium in Berne and one of the oldest Swiss PV-installations on Mont-Soleil in the Jura mountains. Also covered are the efforts made by the utility and its partners in the area of marketing the power under the trade name '1 to 1 energy'. Information for the general public is provided in visitor centres and also by the solar-powered boat on the Lake of Bienne. A further article deals with wind power from the Mont-Crosin Site in the Jura mountains. The third article describes a hydro-electric power station on the river Aare, which, thanks to measures taken in the ecological area, carries the 'Naturemade Star' label for the power it produces.

  18. Origin and outcome of multiple pregnancies in Bern, Switzerland, 1995-2006 and the current proposal of the Swiss parliament to revise the Swiss law of reproductive medicine: Switzerland quo vadis?

    Science.gov (United States)

    Wunder, Dorothea; Neurohr, Eva-Maria; Faouzi, Mohamed; Birkhäuser, Martin H

    2013-09-19

    Infertility treatments are a major source of the increase in multiple pregnancies (MPs). The aims of the present study were (1.) to investigate the origin and maternal/neonatal outcomes of MP and (2.) to review the different measures that can be adopted to reduce these serious complications. The study included all women with multiple births between 1 January 1995 and 31 December 2006 at the University Hospital of Bern, Switzerland. The outcomes associated with the various origins of MP (natural conception, ovarian stimulation [OS]--in-vitro fertilisation [IVF-ICSI]) were analysed using a multinomial logistic regression model. An analysis of the Swiss law on reproductive medicine and its current proposed revision, as well as a literature review using Pubmed, was carried out. A total of 592 MP were registered, 91% (n = 537) resulted in live births. There was significantly more neonatal/maternal morbidity in MP after OS compared with natural conception and even with the IVF-ICSI group. With a policy of elective single embryo transfer (eSET), twin rates after IVF-ICSI can be reduced to <5% and triplets to <1%. After OS, more triplets are found and the outcome of MP is worse. MP is known to be associated with morbidity, mortality, and economic and social risks. To counteract these complications (1.) better training for physicians performing OS should be encouraged and (2.) the Swiss law on reproductive medicine needs to be changed, with the introduction of eSET policies. This would lead to a dramatic decrease in neonatal and maternal morbidity/mortality as well as significant cost reductions for the Swiss healthcare system.

  19. The Bern Infinitesimal Bubble Chamber (BIBC)

    CERN Multimedia

    CERN PhotoLab

    1977-01-01

    The chamber body was machined from a block of aluminium. The visible volume was cylindrical with 65 mm diameter and 35 mm depth. It was filled with propane or freon. It was meant as vertex detector in the search of short-lived particles. It was also used with in-line holography resulting in 8 µm bubble size and 9 cm depth of the field. See E. Ramseyer, B. Hahn and E. Hugentobler, Nucl. Instrum. Methods 201 (1982) 335.

  20. The Marquis de Condorcet goes to Bern

    DEFF Research Database (Denmark)

    Bochsler, Daniel

    2010-01-01

    JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about...

  1. CSL model checking of deterministic and stochastic Petri nets

    NARCIS (Netherlands)

    Martinez Verdugo, J.M.; Haverkort, Boudewijn R.H.M.; German, R.; Heindl, A.

    2006-01-01

    Deterministic and Stochastic Petri Nets (DSPNs) are a widely used high-level formalism for modeling discrete-event systems where events may occur either without consuming time, after a deterministic time, or after an exponentially distributed time. The underlying process dened by DSPNs, under

  2. Model checking conditional CSL for continuous-time Markov chains

    DEFF Research Database (Denmark)

    Gao, Yang; Xu, Ming; Zhan, Naijun

    2013-01-01

    In this paper, we consider the model-checking problem of continuous-time Markov chains (CTMCs) with respect to conditional logic. To the end, we extend Continuous Stochastic Logic introduced in Aziz et al. (2000) [1] to Conditional Continuous Stochastic Logic (CCSL) by introducing a conditional...

  3. Urban hybrid : Bern-Ausserhollingen, Sveits / Inga Raukas, Toomas Tammis

    Index Scriptorium Estoniae

    Raukas, Inga, 1967-

    1999-01-01

    Arhitektuuriagentuuri (Inga Raukas, Toomas Tammis, Tarmo Teedumäe, Eero Endjärv) tööst noorte arhitektide konkursil Europan 5 "Uued elamismaastikud, liikumine ja lähedus". 26.-29. IX 1999 Genfis toimunud rahvusvahelisest foorumist, millel Eestist osalesid Tõnu Laigu ja Inga Raukas. 5 ill

  4. LRN, ERN:, & BERN @ Wireless Integrating the Sciences (WITS) Theatre

    Science.gov (United States)

    Hilliard, L.; Campbell, B.; Foody, M.; Klitsner, D.

    2010-01-01

    In order to develop a call to action for a learning tool that would work to best teach Science Technology Engineering and Math (STEM), the NASA Goddard team will partner with the inventor of Bop It!, an interactive game of verbs and following instructions; and Global Imagination, the developers of Magic Planet. In this paper Decision-making Orbital Health! (DOH!) will be described as a game derived from the basic functions necessary for Bop lt!, a familiar game. that will ask the educational audience to respond to changing commands to Bop It!, Twist It!, and Squeeze It! The success of the new version of the game, will be that the Earth will be making these commands from Dynamic Planet, and the crowd assembled can play wirelessly. Wireless Integrating The Sciences (WITS) Theatre : A balanced approach will describe how the communities local to Goddard and perhaps San Francisco will develop curriculum that helps kids teach kids with an engaging game and a STEM message. The performing arts will be employed to make it entertaining and appropriate to the size of the gathering, and the students educational level.

  5. CSL Model Checking Algorithms for Infinite-state Structured Markov chains

    NARCIS (Netherlands)

    Remke, Anne Katharina Ingrid; Haverkort, Boudewijn R.H.M.; Raskin, J.-F.; Thiagarajan, P.S.

    2007-01-01

    Jackson queueing networks (JQNs) are a very general class of queueing networks that find their application in a variety of settings. The state space of the continuous-time Markov chain (CTMC) that underlies such a JQN, is highly structured, however, of infinite size in as many dimensions as there

  6. 76 FR 53341 - Drawbridge Operation Regulation; Trent River, New Bern, NC

    Science.gov (United States)

    2011-08-26

    ... Friday, except Federal holidays. FOR FURTHER INFORMATION CONTACT: If you have questions on this rule...; telephone 757-398-6587, e-mail [email protected] . If you have questions on viewing the docket...

  7. 76 FR 63858 - Drawbridge Operation Regulation; Trent River, New Bern, NC

    Science.gov (United States)

    2011-10-14

    ...., Monday through Friday, except Federal holidays. FOR FURTHER INFORMATION CONTACT: If you have questions on this rule, call or e-mail Lindsey Middleton, Coast Guard; telephone 757-398-6629, e-mail [email protected] . If you have questions on viewing the docket, call Renee V. Wright, Program Manager...

  8. CSL Issue Paper. March 2008, Volume 3-08. New Media and the Warfighter. Workshop Initial Impressions

    National Research Council Canada - National Science Library

    Murphy, Dennis

    2008-01-01

    .... Anyone armed with mobile technologies such as a camera cell phone and access to the internet is capable of affecting strategic outcomes at very low cost, using a minimal information infrastructure. The U.S...

  9. CSL Issue Paper. March 2008, Volume 3-08. New Media and the Warfighter. Workshop Initial Impressions

    National Research Council Canada - National Science Library

    Murphy, Dennis

    2008-01-01

    .... The global information revolution and rapid spread of the internet and other digital media have leveled the playing field between nation-states, non-state actors, multinational corporations and individuals...

  10. "De Genes y Gentes". Libro del Académico Jaime Eduardo Bernál Villegas

    Directory of Open Access Journals (Sweden)

    Francisco Núñez

    2002-08-01

    Full Text Available

    La amistad con Jaime Eduardo Bernal es, además de un permanente disfrute de sus ocurrencias y de su fino humor, un activo ejercicio intelectual. Todavía me asombra su inagotable capacidad de sorprender.

    Es hombre emprendedor, que con tesón ha culminado exitosamente cada uno de los numerosos proyectos que se ha impuesto.

    Así como lo vemos gozar con cada nueva idea, he sido testigo del entusiasmo con que las desarrolla y de su satisfacción cuando las hace realidad.

    Es un médico profundamente compasivo que busca transmitir la armonía que debe existir entre la aplicación del conocimiento, los hallazgos de la ciencia y un ejercicio médico con hondo sentido humanitario.

    Desde que lo conozco (y ello data de los claustros universitarios, ha trabajado infatigablemente por la humanización de la medicina: no es el investigador frío, que se yergue sobre la neutralidad moral de la ciencia o la invoca para apartarse de su compromiso hipocrático. Tiene muy claros los límites que le impone la moral natural y por consiguiente la ética médica Iniciando el año de 1980, recién llegado de Newcastle, Inglaterra, donde acababa de recibir su PhD en Genética Humana después de largos años de especialización, ingresó a la sala de profesores del departamento de Pediatría de la Universidad Javeriana, donde solíamos reunirnos a debatir los casos clínicos de nuestros pacientes. Jaime Eduardo entró calmadamente, en su mano un maletín y en él una libreta que llamaba “el libro de las Ideas” y así estaba rotulada; se hallaban consignados allí muchos de los que habrían de convertirse en proyectos de investigación y más tarde en exitosas investigaciones y publicaciones.

    Ocupó un escritorio y me dijo “vamos a ver qué se puede hacer, vengo a pensar…“. No había transcurrido mucho tiempo cuando sus ideas y alrededor de ellas un pequeño grupo de investigadores ya nos habían desalojado de nuestra sala de profesores; meses después ocupó un área aledaña al laboratorio clínico del hospital de San Ignacio que, al poco tiempo, fue también insuficiente para albergarlo, con todas sus ideas y proyectos en vigoroso desarrollo; se percibía allí una actividad permanente, llena del entusiasmo que caracteriza cada sueño que Bernal quiere hacer real...

  11. Mont Terri Project - Heater experiment, engineered barriers emplacement and ventilations tests. No 1 - Swiss Geological Survey, Bern, 2007

    International Nuclear Information System (INIS)

    Bossart, P.; Nussbaum, C.

    2007-01-01

    The international Mont Terri project started in January 1996. Research is carried out in the Mont Terri rock laboratory, an underground facility near the security gallery of the Mont Terri motorway tunnel (vicinity of St-Ursanne, Canton of Jura, Switzerland). The aim of the project is the geological, hydrogeological, geochemical and geotechnical characterisation of a clay formation, specifically of the Opalinus Clay. Twelve Partners from European countries and Japan participate in the project. These are ANDRA, BGR, CRIEPI, ENRESA, GRS, HSK, IRSN, JAEA, NAGRA, OBAYASHI, SCK.CEN and swisstopo. Since 2006, swisstopo acts as operator of the rock laboratory and is responsible for the implementation of the research programme decided by the partners. The three following reports are milestones in the research history of the Mont Terri project. It was the first time that an in-situ heating test with about 20 observation boreholes over a time span of several years was carried out in a clay formation. The engineered barrier emplacement experiment has been extended due to very encouraging measurement results and is still going on. The ventilation test was and is a challenge, especially in the very narrow microtunnel. All three projects were financially supported by the European Commission and the Swiss State Secretariat for Education and Research. The three important scientific and technical reports, which are presented in the following, have been provided by a number of scientists, engineers and technicians from the Partners, but also from national research organisations and private contractors. Many fruitful meetings where held, at the rock laboratory and at other facilities, not to forget the weeks and months of installation and testing work carried out by the technicians and engineers. The corresponding names and organisations are listed in detail in the reports. Special thanks are going to the co-ordinators of the three projects for their motivation of the team during planning, instrumentation, testing and interpretation. These are Juan Carlos Mayor and Fernando Huertas from ENRESA, and lngeborg Goebel from BGR. We would also like to warmly thank Christopher Davies from the European Commission for his endurable support of the three projects. Finally, we would like to express our thanks to all Mont Terri Partners for their excellent collaboration and the federal and cantonal authorities for their support in the project. The authors accept sole responsibility for the content of the reports. Further information on the Mont Terri project can be found on the web site www.mont-terri.ch. (author)

  12. 2016 Consensus statement on return to sport from the First World Congress in Sports Physical Therapy, Bern

    OpenAIRE

    Ardern, Clare L.; Glasgow, Philip; Schneiders, Anthony; Witvrouw, Erik; Clarsen, Benjamin; Cools, Ann; Gojanovic, Boris; Griffin, Steffan; Khan, Karim M.; Moksnes, Havard; Mutch, Stephen A.; Phillips, Nicola; Reurink, Gustaaf; Sadler, Robin; Silbernagel, Karin Gravare

    2016-01-01

    Copyright © 2017 BMJ Publishing Group Deciding when to return to sport after injury is complex and multifactorial—an exercise in risk management. Return to sport decisions are made every day by clinicians, athletes and coaches, ideally in a collaborative way. The purpose of this consensus statement was to present and synthesise current evidence to make recommendations for return to sport decision-making, clinical practice and future research directions related to returning athletes to spor...

  13. Nonlocal quantum field theory within the framework of the Bogolyubov axiomatic approach. 6. CSL topologization of the space (psi(Rsup(4n), F)tau)

    Energy Technology Data Exchange (ETDEWEB)

    Sabad, E P; Lomsadze, Yu M [AN Ukrainskoj SSR, Kiev. Inst. Teoreticheskoj Fiziki

    1980-01-01

    It is proved that each of the classes PHI*(Rsup(4n),F) investigated by means of suitable local topologization can be transformed into a concrete realization of the abstract class SR(..cap omega..sub(f)sup(a) ..-->.. C/sup 1/) of complexly spread reducible generalized functions. The class PHI*(Rsup(4n),F) preset by a certain representation on the basis of signal ideology is proved to be a class of generalized functions over the Poincare-invariant complete topological locally convex linear involutive space (PHI(Rsup(4n),F),Q) of test functions with the topology Q preset by a countable number of norms. These results allow a correct formulation of the axiom of complexly broken microcausality.

  14. Self-diffusion in the non-Newtonian regime of shearing liquid crystal model systems based on the Gay-Berne potential

    Energy Technology Data Exchange (ETDEWEB)

    Sarman, Sten, E-mail: sarman@ownit.nu; Wang, Yong-Lei; Laaksonen, Aatto [Arrhenius Laboratory, Department of Materials and Environmental Chemistry, Stockholm University, 106 91 Stockholm (Sweden)

    2016-02-07

    The self-diffusion coefficients of nematic phases of various model systems consisting of regular convex calamitic and discotic ellipsoids and non-convex bodies such as bent-core molecules and soft ellipsoid strings have been obtained as functions of the shear rate in a shear flow. Then the self-diffusion coefficient is a second rank tensor with three different diagonal components and two off-diagonal components. These coefficients were found to be determined by a combination of two mechanisms, which previously have been found to govern the self-diffusion of shearing isotropic liquids, namely, (i) shear alignment enhancing the diffusion in the direction parallel to the streamlines and hindering the diffusion in the perpendicular directions and (ii) the distortion of the shell structure in the liquid whereby a molecule more readily can escape from a surrounding shell of nearest neighbors, so that the mobility increases in every direction. Thus, the diffusion parallel to the streamlines always increases with the shear rate since these mechanisms cooperate in this direction. In the perpendicular directions, these mechanisms counteract each other so that the behaviour becomes less regular. In the case of the nematic phases of the calamitic and discotic ellipsoids and of the bent core molecules, mechanism (ii) prevails so that the diffusion coefficients increase. However, the diffusion coefficients of the soft ellipsoid strings decrease in the direction of the velocity gradient because the broadsides of these molecules are oriented perpendicularly to this direction due the shear alignment (i). The cross coupling coefficient relating a gradient of tracer particles in the direction of the velocity gradient and their flow in the direction of the streamlines is negative and rather large, whereas the other coupling coefficient relating a gradient in the direction of the streamlines and a flow in the direction of the velocity gradient is very small.

  15. Self-diffusion in the non-Newtonian regime of shearing liquid crystal model systems based on the Gay-Berne potential

    Science.gov (United States)

    Sarman, Sten; Wang, Yong-Lei; Laaksonen, Aatto

    2016-02-01

    The self-diffusion coefficients of nematic phases of various model systems consisting of regular convex calamitic and discotic ellipsoids and non-convex bodies such as bent-core molecules and soft ellipsoid strings have been obtained as functions of the shear rate in a shear flow. Then the self-diffusion coefficient is a second rank tensor with three different diagonal components and two off-diagonal components. These coefficients were found to be determined by a combination of two mechanisms, which previously have been found to govern the self-diffusion of shearing isotropic liquids, namely, (i) shear alignment enhancing the diffusion in the direction parallel to the streamlines and hindering the diffusion in the perpendicular directions and (ii) the distortion of the shell structure in the liquid whereby a molecule more readily can escape from a surrounding shell of nearest neighbors, so that the mobility increases in every direction. Thus, the diffusion parallel to the streamlines always increases with the shear rate since these mechanisms cooperate in this direction. In the perpendicular directions, these mechanisms counteract each other so that the behaviour becomes less regular. In the case of the nematic phases of the calamitic and discotic ellipsoids and of the bent core molecules, mechanism (ii) prevails so that the diffusion coefficients increase. However, the diffusion coefficients of the soft ellipsoid strings decrease in the direction of the velocity gradient because the broadsides of these molecules are oriented perpendicularly to this direction due the shear alignment (i). The cross coupling coefficient relating a gradient of tracer particles in the direction of the velocity gradient and their flow in the direction of the streamlines is negative and rather large, whereas the other coupling coefficient relating a gradient in the direction of the streamlines and a flow in the direction of the velocity gradient is very small.

  16. The barley (Hordeum vulgare) cellulose synthase-like D2 gene (HvCslD2) mediates penetration resistance to host-adapted and nonhost isolates of the powdery mildew fungus

    NARCIS (Netherlands)

    Douchkov, Dimitar; Lueck, Stefanie; Hensel, Goetz; Kumlehn, Jochen; Rajaraman, Jeyaraman; Johrde, Annika; Doblin, Monika S.; Beahan, Cherie T.; Kopischke, Michaela; Fuchs, René; Lipka, Volker; Niks, Rients E.; Bulone, Vincent; Chowdhury, Jamil; Little, Alan; Burton, Rachel A.; Bacic, Antony; Fincher, Geoffrey B.; Schweizer, Patrick

    2016-01-01

    Cell walls and cellular turgor pressure shape and suspend the bodies of all vascular plants. In response to attack by fungal and oomycete pathogens, which usually breach their host's cell walls by mechanical force or by secreting lytic enzymes, plants often form local cell wall appositions

  17. Assessing the effect of leachate of copper slag from the ISASMELT process on cell growth and proximate components in microalgae, Chlorella vulgaris (Beijerinck)

    Digital Repository Service at National Institute of Oceanography (India)

    Harish, V.; Sreepada, R.A.; Suryavanshi, U.; Shanmuganathan, P.; Sumathy, A.

    -exposed cultures were significantly higher than the controls. Although the cells of C. vulgaris exposed to CSL accumulated numerically elevated levels of total lipid (TL) compared to control, exposure of C. vulgaris to 100% CSL did not induce stress proteins...

  18. Predictors and consequences of rural clients' satisfaction level in the district public-private mixed health system of Bangladesh

    NARCIS (Netherlands)

    Roy, Ashim; van der Weijden, Trudy; de Vries, Nanne

    2017-01-01

    Background: We investigated predictors of the rural clients' satisfaction level (CSL), and interlinks between perceived specific service quality (PSSQ), perceived utility value (PUV), CSL, and clients' reactions (CR) towards current and future utilization of providers and facilities in the

  19. Dicty_cDB: SHD815 [Dicty_cDB

    Lifescience Database Archive (English)

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    Lifescience Database Archive (English)

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  1. Dicty_cDB: CHE850 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available DILFNGI EYQCKGWISGFTKCDWKGDSIER--- ---ESLEGNMIENQYITLKTQTHST**r*csl*nlgrlccq*sr*ti*nqylcsrysft* ere*k*tfhslgkr*e*itlmaw**vn*frid...---ESLEGNMIENQYITLKTQTHST**r*csl*nlgrlccq*sr*ti*nqylcsrysft* ere*k*tfhslgkr*e*itlmaw**vn*fridclagikncsticskn

  2. Model Checking Algorithms for CTMDPs

    DEFF Research Database (Denmark)

    Buchholz, Peter; Hahn, Ernst Moritz; Hermanns, Holger

    2011-01-01

    Continuous Stochastic Logic (CSL) can be interpreted over continuoustime Markov decision processes (CTMDPs) to specify quantitative properties of stochastic systems that allow some external control. Model checking CSL formulae over CTMDPs requires then the computation of optimal control strategie...

  3. Measures to increase traffic law acceptance : some strategic considerations. Paper presented at the 5th European workshop `New developments in traffic safety research', Bern, May 2-3, 1996.

    NARCIS (Netherlands)

    Goldenbeld, C.

    1997-01-01

    The set of traffic laws and rules intends to maximise the possibilities for free movement in the traffic system, while at the same time safeguarding road safety. Acceptance of traffic laws depends in part on properties of the laws and rules themselves that determine how they will be perceived or

  4. Chickpea (Cicer arietinum steep liquor as a leavening agent: Effect on dough rheology and sensory properties of bread

    Directory of Open Access Journals (Sweden)

    Saad Ahmed M.

    2015-01-01

    Full Text Available Dough fermentation is one of the oldest process in food technologies. It has been recently intensively studied for its impact on the sensory, structural, nutritional and shelf life properties of leavened baked products. The goals of this work were to investigate chickpea steep liquor (CSL as a dough-leavening agent and to study the effect of CSL on the dough rheology and sensory properties of leavened bread. CSL was prepared by submerging chickpea seeds in boiled distilled water (1:2, w/v for 24 h at 37оC, and then obtained liquor was filtered and freeze-dried to obtain CSL. The addition of CSL to wheat flour (WF brought changes in the dough mixing behavior as measured by the farinograph. An increase in the farinograph water absorption of WF dough was observed when 4.5% CSL and 1.5% yeast was added, while arrival time was not affected. Addition of CSL to the dough at a content of 4.5, 9.0 and 13.5 g CSL/300 g WF caused an increase in dough stability. The CSL addition also increased mechanical tolerance index, dough weakening and mixing time. Dough development time for all blends was higher than the control (1.2-1.5 min, while between the CSL samples no significant difference was observed. The loaf weight slightly increased from 146.2 g for control to 152.2 g for CSL fermented bread, whereas the loaf volume and specific volume of CSL-fermented bread were lower than the control. The combination of yeast and CSL increased the acceptability of bread with the increasing level of both leavening agents’. The results show that CSL could be used as an alternative to yeast for syngas fermentation. On the other hand, CLS is rich in nutrients and lower in cost compared to yeast.

  5. Chlamydia control in Europe - a survey of Member States

    DEFF Research Database (Denmark)

    Andersen, Berit; van Bergen, J; Ward, H

    ), contributed to the design and interpretation of the survey, commented on the draft report and approved the final report. Shelagh Redmond (Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland) provided technical support. Nicola Low (University of Bern) led the Chlamydia Control...

  6. Corn steep liquor as a nutritional source for biocementation and its impact on concrete structural properties.

    Science.gov (United States)

    Joshi, Sumit; Goyal, Shweta; Reddy, M Sudhakara

    2018-05-28

    Microbial-induced carbonate precipitation (MICP) has a potential to improve the durability properties and remediate cracks in concrete. In the present study, the main emphasis is placed upon replacing the expensive laboratory nutrient broth (NB) with corn steep liquor (CSL), an industrial by-product, as an alternate nutrient medium during biocementation. The influence of organic nutrients (carbon and nitrogen content) of CSL and NB on the chemical and structural properties of concrete structures is studied. It has been observed that cement-setting properties were unaffected by CSL organic content, while NB medium influenced it. Carbon and nitrogen content in concrete structures was significantly lower in CSL-treated specimens than in NB-treated specimens. Decreased permeability and increased compressive strength were reported when NB is replaced with CSL in bacteria-treated specimens. The present study results suggest that CSL can be used as a replacement growth medium for MICP technology at commercial scale.

  7. Classification and analysis of corn steep liquor by UPLC/Q-TOF MS and HPLC.

    Science.gov (United States)

    Xiao, Xue; Hou, Yuanyuan; Liu, Yang; Liu, Yanjie; Zhao, Hongzhi; Dong, Linyi; Du, Jun; Wang, Yiming; Bai, Gang; Luo, Guoan

    2013-03-30

    Corn steep liquor (CSL), an important raw material with high nutritional value, serves as a nitrogen source in the fermentation industry. The CSL quality directly affects the yield and quality of fermentation products. In this work, a fingerprinting technique was used to identify the potential markers of CSL. Forty-two CSL samples from different manufacturers were profiled by ultra-performance liquid chromatography with tandem quadrupole time-of-flight mass spectrometry. Sixteen compounds, almost all of which were amino acids and their derivatives, were considered as the potential markers. Then, o-phthalaldehyde-9-fluorenylmethyl chloroformate precolumn derivatization by high-performance liquid chromatography was performed to identify the free amino acids in CSL. Principal component analysis (PCA) was used to distinguish among the samples from different manufacturers. The results demonstrated that the fingerprinting technique combined with PCA analysis was a powerful tool for determining the CSL quality. Copyright © 2013 Elsevier B.V. All rights reserved.

  8. Cross-situational word learning in aphasia.

    Science.gov (United States)

    Peñaloza, Claudia; Mirman, Daniel; Cardona, Pedro; Juncadella, Montserrat; Martin, Nadine; Laine, Matti; Rodríguez-Fornells, Antoni

    2017-08-01

    Human learners can resolve referential ambiguity and discover the relationships between words and meanings through a cross-situational learning (CSL) strategy. Some people with aphasia (PWA) can learn word-referent pairings under referential uncertainty supported by online feedback. However, it remains unknown whether PWA can learn new words cross-situationally and if such learning ability is supported by statistical learning (SL) mechanisms. The present study examined whether PWA can learn novel word-referent mappings in a CSL task without feedback. We also studied whether CSL is related to SL in PWA and neurologically healthy individuals. We further examined whether aphasia severity, phonological processing and verbal short-term memory (STM) predict CSL in aphasia, and also whether individual differences in verbal STM modulate CSL in healthy older adults. Sixteen people with chronic aphasia underwent a CSL task that involved exposure to a series of individually ambiguous learning trials and a SL task that taps speech segmentation. Their learning ability was compared to 18 older controls and 39 young adults recruited for task validation. CSL in the aphasia group was below the older controls and young adults and took place at a slower rate. Importantly, we found a strong association between SL and CSL performance in all three groups. CSL was modulated by aphasia severity in the aphasia group, and by verbal STM capacity in the older controls. Our findings indicate that some PWA can preserve the ability to learn new word-referent associations cross-situationally. We suggest that both PWA and neurologically intact individuals may rely on SL mechanisms to achieve CSL and that verbal STM also influences CSL. These findings contribute to the ongoing debate on the cognitive mechanisms underlying this learning ability. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. Isolation of a sex-linked DNA sequence in cranes.

    Science.gov (United States)

    Duan, W; Fuerst, P A

    2001-01-01

    A female-specific DNA fragment (CSL-W; crane sex-linked DNA on W chromosome) was cloned from female whooping cranes (Grus americana). From the nucleotide sequence of CSL-W, a set of polymerase chain reaction (PCR) primers was identified which amplify a 227-230 bp female-specific fragment from all existing crane species and some other noncrane species. A duplicated versions of the DNA segment, which is found to have a larger size (231-235 bp) than CSL-W in both sexes, was also identified, and was designated CSL-NW (crane sex-linked DNA on non-W chromosome). The nucleotide similarity between the sequences of CSL-W and CSL-NW from whooping cranes was 86.3%. The CSL primers do not amplify any sequence from mammalian DNA, limiting the potential for contamination from human sources. Using the CSL primers in combination with a quick DNA extraction method allows the noninvasive identification of crane gender in less than 10 h. A test of the methodology was carried out on fully developed body feathers from 18 captive cranes and resulted in 100% successful identification.

  10. Dicty_cDB: AHA817 [Dicty_cDB

    Lifescience Database Archive (English)

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  11. Dicty_cDB: SHF645 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available -KKQTESLEGNMIENQYITLKTKLTXT**r*csl*nlgrlccq*sr*ti*nqylcsry sft*ere*k*tfhslgkr*e*itlmaw**vn*fridclagikncstics... EYQCKGWISGFTKCDWKGDSIERWAVQFPDDLS--- ---KKQTESLEGNMIENQYITLKTKLTXT**r*csl*nlgrlccq*sr*ti*nqylcsry sft*ere*k...*tfhslgkr*e*itlmaw**vn*fridclagikncsticsknwlqiw*ryl fc*ly**iiqllfhik*lsnctyvim*sftw*he*iet*yxygrgttsip*yksfr

  12. Dicty_cDB: SHB222 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available PT**r*csl*nlgrl ccq*sr*ti*nqylcsrysft*ere*k*tfhslgkr*e*itlma***vn*fridclagik ncsticsknwlqiw*rylfc*ly**iiqllf...DIAANLKKQTESLEGNMIENQYITLKTKLTPT**r*csl*nlgrl ccq*sr*ti*nqylcsrysft*ere*k*tfhslgkr*e*itlma***vn*fridclagik n

  13. Model Checking Infinite-State Markov Chains

    NARCIS (Netherlands)

    Remke, Anne Katharina Ingrid; Haverkort, Boudewijn R.H.M.; Cloth, L.

    2004-01-01

    In this paper algorithms for model checking CSL (continuous stochastic logic) against infinite-state continuous-time Markov chains of so-called quasi birth-death type are developed. In doing so we extend the applicability of CSL model checking beyond the recently proposed case for finite-state

  14. EFFECT OF SUPPLEMENTING DIFFERENT LEVELS OF CORN STEEP LIQUOR ON THE POST-WEANING GROWTH PERFORMANCE OF PAK-KARAKUL LAMBS

    Directory of Open Access Journals (Sweden)

    M. A. MIRZA AND T. MUSHTAQ

    2006-07-01

    Full Text Available Corn steep liquor (CSL is a liquid by-product of wet milling process of maize-starch industry. A trial was conducted to examine the effect of supplementing various levels of CSL in the diet of 30 Pak-Karakul lambs. These lambs were randomly divided into five experimental groups. The control group (A was fed on basal diet having no CSL. The experimental groups B, C, D and E were fed on diets supplemented with CSL at the rate of 5, 10, 15 and 20% of the diet, respectively. The experimental diets were fed ad libitum to the experimental animals for 90 days. Results showed that supplementation of CSL at 5% of the diet improved both body weight gain and feed:gain. Corn steep liquor at higher supplemental rates i.e., 10 or 15% of the basal diet had non-significant effect on the growth or feed:gain of lambs. However, supplementation of CSL at 20% of the diet significantly depressed growth (P <0.01 and feed:gain (P<0.01. Growth rate in male lambs was significantly (P <0.01 higher than those of female lambs. Female lambs consumed more ration for each unit body weight gain than males. The results of the trial demonstrate that supplementation of CSL at 5% of the diet is useful for growth and feed:gain but higher levels of CSL considerably depress growth and increase feed:gain, leading to increased cost of production.

  15. Optimization of liquid-liquid extraction of biosurfactants from corn steep liquor.

    Science.gov (United States)

    Vecino, X; Barbosa-Pereira, L; Devesa-Rey, R; Cruz, J M; Moldes, A B

    2015-09-01

    In this work, the optimization of the operational conditions for the chloroform-based extraction of surface-active compounds from corn steep liquor (CSL) was carried out and the nutritional properties of the remnant aqueous phase (CSL-less biosurfactant) was evaluated as microbial fermentation medium. The optimal conditions to obtain biosurfactants from CSL were as follows: chloroform/CSL ratio 2 (v/v), 56 °C at extraction times >30 min. At the optima conditions, 100 % of biosurfactant extract can be obtained from CSL, obtaining 12.0 ± 0.5 g of biosurfactant extract/Kg of CSL. The critical micelle concentration (CMC) of the biosurfactant extract was 399.4 mg L(-1). This value is similar to the CMC of cetrimonium bromide (CTAB), a cationic surfactant used in the formulation of nanoparticles. The extraction of biosurfactant can be also carried out at room temperature although in this case, the extraction yield decreased about 15 %. The extraction of surface-active compounds from agroindustrial streams can suppose important advances for the bio-based surfactants industry. Biosurfactants obtained in this work are not only more eco-friendly than chemical detergents but also can be cost competitive with its chemical counterparts. Furthermore, after the extraction of surface-active compounds, CSL-less biosurfactant was found to be suitable as nutritional supplement for lactic acid bacteria, maintaining its nutritional properties in comparison with regular CSL.

  16. Functional genomic analysis supports conservation of function among cellulose synthase-like a gene family members and suggests diverse roles of mannans in plants

    DEFF Research Database (Denmark)

    Liepman, Aaron H; Nairn, C Joseph; Willats, William G T

    2007-01-01

    from Arabidopsis (Arabidopsis thaliana), guar (Cyamopsis tetragonolobus), and Populus trichocarpa catalyze beta-1,4-mannan and glucomannan synthase reactions in vitro. Mannan polysaccharides and homologs of CslA genes appear to be present in all lineages of land plants analyzed to date. In many plants......, the CslA genes are members of extended multigene families; however, it is not known whether all CslA proteins are glucomannan synthases. CslA proteins from diverse land plant species, including representatives of the mono- and dicotyledonous angiosperms, gymnosperms, and bryophytes, were produced...... they are prevalent at cell junctions and in buds. Taken together, these results demonstrate that members of the CslA gene family from diverse plant species encode glucomannan synthases and support the hypothesis that mannans function in metabolic networks devoted to other cellular processes in addition to cell wall...

  17. Effects of feeding different levels of corn steep liquor on the performance of fattening lambs.

    Science.gov (United States)

    Azizi-Shotorkhoft, A; Sharifi, A; Mirmohammadi, D; Baluch-Gharaei, H; Rezaei, J

    2016-02-01

    This study was conducted to assess the effect of feeding corn steep liquor (CSL) on in vivo digestibility, ruminal pH, ammonia and hydrolytic enzyme activities, blood metabolites, feed intake (FI) and growth performance in fattening lambs. The CSL is a by-product of wet milling process of maize starch industry. The crude protein (CP), rumen-degradable protein (RDP), lactic acid and metabolisable energy contents of this by-product were 420, 324, 200 g/kg dry matter (DM) and 12.6 MJ/kg DM respectively. Twenty-seven male Moghani lambs were assigned randomly into three groups of nine lambs each in a completely randomised design. Three iso-energetic and iso-nitrogenous diets containing different levels (0, 50 or 100 g/kg dry matter) of CSL were offered ad libitum three times a day. Forage to concentrate ratio of the diets was 30:70. With inclusion of CSL in diet, the contents of canola meal, fish meal, wheat bran, corn grain and sugar beet pulp were decreased. The contents of DM, ash-free neutral detergent fibre (NDFom), ether extract, starch, Ca and S were numerically lower, but soluble protein, RDP and non-fibre carbohydrates were greater in the diets containing CSL in comparison with the control diet. The lambs fed with the diets containing CSL had lower [linear (L), p < 0.06] digestibility coefficients of DM and NDFom as compared to those fed with the diet free of CSL. Ruminal ammonia-N concentration increased (L, p < 0.05), but pH decreased (L, p < 0.05) with raising CSL level in diet. Carboxymethyl cellulase and filter paper-degrading activities decreased (L, p < 0.05), while proteases activity increased (L, p < 0.05) as dietary rates of CSL increased. Microcrystalline cellulase and ɑ-amylase activities were similar among the treatments. Within blood metabolites, only urea-N concentration increased (L, p < 0.05) in the lambs receiving CSL as compared to those fed with diet without CSL. Dietary inclusion of CSL resulted in linear decreases (L, p < 0.05) in the

  18. Berní zatížení českého venkova v první polovině 19. století a úskalí jeho studia // The tax burden on the Czech countryside in the first half of the 19th century and some pitfalls in its studies

    Directory of Open Access Journals (Sweden)

    Jan Lhoták

    2017-08-01

    Full Text Available The paper summarises the possibilities of studying the tax burden on the Czech countryside in 1780–1850. For its analysis it proposes to use the archival collection ‘Contribution Funds’, consisting of individual schedules for the planned contributions (so-called sub-repartitions, and contributory accounts recording all receipts and outlays. Due to the limited ‘sub-repartition’ for land tax only, it recommends to use the sums in the contributory accounts and to work with values for the whole estate. The most suitable comparative figures are grain prices, preserved from commodity prices that are important for the rural environment in the most comprehensive price ranges. Both series of numbers need to be subjected to source criticism (the most important for the period under review is the variability of the currencies used and then compared with each other.

  19. Journalism that Matters: Views from Central and Eastern Europe. By Michał Głowacki, Epp Lauk and Auksė Balčytienė. Bern: Peter Lang, 2014, 214 pp.; ISBN: 978-3-631-65421-7 hb.

    Directory of Open Access Journals (Sweden)

    Elena Rodina

    2015-12-01

    Full Text Available This book is a much-needed contribution to journalistic studies that allows us to have a closer and more nuanced look at media systems and press cultures in the countries of Central and Eastern Europe (CEE from a non-Western perspective. The volume is of high value to anyone who is interested in the diversity that underlies the unifying term of “post-communist media.” Most of its authors rely on rich data collected throughout lengthy periods of time on the territory of Central and Eastern Europe, which allows us to see not only the current state of “Eastern” media, but its development throughout time.

  20. Szeminárium és bibliakritika: Elzász Bernát és a Rabbiképző Teológiai Egylete az Egyenlőség hasábjain

    NARCIS (Netherlands)

    Biró, T.; Babits, A.

    2013-01-01

    Title translated to English: "Seminary and Bible Criticism: Bernhard Elsass and the Theological Society of the Rabbinical Seminary [in Budapest] in the [newspaper] Egyenloseg". Published in a volume commemorating the 100th anniversary of the birth of Alexander Scheiber.

  1. Profiling Perceptual Learning Styles of Chinese as a Second Language Learners in University Settings.

    Science.gov (United States)

    Sun, Peijian Paul; Teng, Lin Sophie

    2017-12-01

    This study revisited Reid's (1987) perceptual learning style preference questionnaire (PLSPQ) in an attempt to answer whether the PLSPQ fits in the Chinese-as-a-second-language (CSL) context. If not, what are CSL learners' learning styles drawing on the PLSPQ? The PLSPQ was first re-examined through reliability analysis and confirmatory factor analysis (CFA) with 224 CSL learners. The results showed that Reid's six-factor PLSPQ could not satisfactorily explain the CSL learners' learning styles. Exploratory factor analyses were, therefore, performed to explore the dimensionality of the PLSPQ in the CSL context. A four-factor PLSPQ was successfully constructed including auditory/visual, kinaesthetic/tactile, group, and individual styles. Such a measurement model was cross-validated through CFAs with 118 CSL learners. The study not only lends evidence to the literature that Reid's PLSPQ lacks construct validity, but also provides CSL teachers and learners with insightful and practical guidance concerning learning styles. Implications and limitations of the present study are discussed.

  2. Effect of corn steep liquor on lettuce root rot (Fusarium oxysporum f.sp. lactucae) in hydroponic cultures.

    Science.gov (United States)

    Chinta, Yufita D; Kano, Kazuki; Widiastuti, Ani; Fukahori, Masaru; Kawasaki, Shizuka; Eguchi, Yumi; Misu, Hideyuki; Odani, Hiromitsu; Zhou, Songying; Narisawa, Kazuhiko; Fujiwara, Kazuki; Shinohara, Makoto; Sato, Tatsuo

    2014-08-01

    Recent reports indicate that organic fertilisers have a suppressive effect on the pathogens of plants grown under hydroponic systems. Furthermore, microorganisms exhibiting antagonistic activity to diseases have been observed in organic hydroponic systems. This study evaluated the effect of corn steep liquor (CSL) on controlling lettuce root rot disease [Fusarium oxysporum f.sp. lactucae (FOL)] in a hydroponic system. The effect of CSL and Otsuka A (a chemical fertiliser) on the inhibition of FOL in terms of mycelial growth inhibition was tested in vivo. Addition of CSL suppressed FOL infection rates. CSL inhibited FOL infection by 26.3-42.5% from 2 days after starting incubation. In comparison, Otsuka A inhibited FOL growth by 5.5-19.4%. In addition, four of 10 bacteria isolated from the nutrient media containing CSL exhibited inhibition zones preventing FOL mycelial growth. We found that CSL suppressed FOL in lettuce via its antifungal and biostimulatory effects. We suggest that activation of beneficial microorganisms present in CSL may be used to decrease lettuce root rot disease and contribute to lettuce root growth. © 2014 Society of Chemical Industry.

  3. Natural and anthropogenic influences on depositional architecture of the Ural Delta, Kazakhstan, northern Caspian Sea, during the past 70 years

    Science.gov (United States)

    Scarelli, Frederico M.; Cantelli, Luigi; Barboza, Eduardo G.; Gabbianelli, Giovanni

    2017-05-01

    This paper focuses on the Ural Delta in the northern zone of the Caspian Sea, an area with particular characteristics, where intense influence from anthropogenic and natural factors exists, which acts on the fragile delta system. We built a database to integrate the data from the published sources, bathymetric survey, and recent images in the geographical information system (GIS) environment. The results were linked to the Caspian Sea level (CSL) curve, which had many variations, changing the Ural Delta system's dynamics and in its architecture. In addition, the anthropogenic changes contribute to shaping the actual Ural Delta architecture. Through the link between the results and CSL, we reconstructed an evolution model for the Ural Delta system for the last century and identified three different architectures for the Ural Delta, determined by the energy that acted on the system in the last century and by the anthropogenic changes. This work identifies six different delta phases, which are shaped by CSL changes during the last 70 years and by anthropogenic changes. The delta phases recognized are: i) a Lobate Delta phase, shaped during high CSL before 1935; ii) Natural Elongate Delta 1935-1950 formed during rapid CSL fall; iii) Anthropogenic Elongate Delta 1950-1966, formed during rapid CSL fall and after the Ural-Caspian Sea canal construction, which modified the sedimentary deposition on the delta; iv) Anthropogenic Elongate Delta 1966-1982 shaped during low CSL phase; v) Anthropogenic Elongate Delta 1982-1996 formed during a rapid CSL rise phase; and vi) Anthropogenic Elongate Delta 1996-2009 shaped during high CSL that represent the last phase and actual Ural Delta architecture.

  4. Design and Effectiveness of a Required Pre-Clinical Simulation-based Curriculum for Fundamental Clinical Skills and Procedures

    Directory of Open Access Journals (Sweden)

    Daryl P. Lofaso

    2011-12-01

    Full Text Available For more than 20 years, medical literature has increasingly documented the need for students to learn, practice and demonstrate competence in basic clinical knowledge and skills. In 2001, the Louisiana State University Health Science Centers (LSUHSC School of Medicine – New Orleans replaced its traditional Introduction in to Clinical Medicine (ICM course with the Science and Practice of Medicine (SPM course. The main component within the SPM course is the Clinical Skills Lab (CSL. The CSL teaches 30 plus skills to all pre-clinical medical students (Years 1 and 2. Since 2002, an annual longitudinal evaluation questionnaire was distributed to all medical students targeting the skills taught in the CSL. Students were asked to rate their self- confidence (Dreyfus and Likert-type and estimate the number of times each clinical skill was performed (clinically/non-clinically. Of the 30 plus skills taught, 8 were selected for further evaluation. An analysis was performed on the eight skills selected to determine the effectiveness of the CSL. All students that participated in the CSL reported a significant improvement in self-confidence and in number performed in the clinically/non-clinically setting when compared to students that did not experience the CSL. For example, without CSL training, the percentage of students reported at the end of their second year self-perceived expertise as “novice” ranged from 21.4% (CPR to 84.7% (GU catheterization. Students who completed the two-years CSL, only 7.8% rated their self-perceived expertise at the end of the second year as “novice” and 18.8% for GU catheterization. The CSL design is not to replace real clinical patient experiences. It's to provide early exposure, medial knowledge, professionalism and opportunity to practice skills in a patient free environment.

  5. Chiral soliton lattice and charged pion condensation in strong magnetic fields

    Energy Technology Data Exchange (ETDEWEB)

    Brauner, Tomáš [Faculty of Science and Technology, University of Stavanger,N-4036 Stavanger (Norway); Yamamoto, Naoki [Department of Physics, Keio University,Yokohama 223-8522 (Japan)

    2017-04-21

    The Chiral Soliton Lattice (CSL) is a state with a periodic array of topological solitons that spontaneously breaks parity and translational symmetries. Such a state is known to appear in chiral magnets. We show that CSL also appears as a ground state of quantum chromodynamics at nonzero chemical potential in a magnetic field. By analyzing the fluctuations of the CSL, we furthermore demonstrate that in strong but achievable magnetic fields, charged pions undergo Bose-Einstein condensation. Our results, based on a systematic low-energy effective theory, are model-independent and fully analytic.

  6. Feeding and growth in a captive-born bottlenose dolphin Tursiops ...

    African Journals Online (AJOL)

    1991-06-12

    Jun 12, 1991 ... The feeding and growth of a captive-born bottlenose dolphin Tursiops truncatus calf were studied for 30 months post ..... was made between suckling from the left or right in further analyses. .... possibly more important function is that this tail position .... Institute of Brain Anatomy, University of Berne, Berne,.

  7. Séminaire de physique corpusculaire | 27 February

    CERN Multimedia

    2013-01-01

      The new Bern cyclotron laboratory for PET radioisotope production and its beam line for multi-disciplinary research, by Dr Saverio Braccini, Albert Einstein Center for Fundamental Physics, University of Bern. Wednesday 27 February 2013 at 11:15 Science III, Auditoire 1S081 30, quai Ernest-Ansermet, 1211 Genève 4 Abstract: The new Bern cyclotron laboratory is based on a 18 MeV proton cyclotron equipped with a specifically conceived 6 m long research beam line, terminated in a separate bunker. This particular configuration is designed for industrial Positron Emission Tomography (PET) radioisotope production as well as for novel detector, radiation biophysics, radiation protection, materials science, radiochemistry and radiopharmacy scientific activities. This project is the result of the successful collaboration among the University Hospital in Bern (Inselspital), the University of Bern, private investors and industrial partners. This new facility is now operational and open to nation...

  8. eia

    African Journals Online (AJOL)

    Dr Tanya du Plessis

    promote, among other things, ecologically sustainable development, the government of ..... energy. What about solar energy for lighting and gas for cooking? These ..... CSL Forum 2007 An Energy Summary of South Africa [Found on internet].

  9. 76 FR 62850 - Curtis-Straus LLC; Application for Renewal of Recognition

    Science.gov (United States)

    2011-10-11

    ... lines of these companies. The organizational chart provided by CSL on January 31, 2008 (Ex. 5; Ex. 1... and Dental Equipment; UL 60601-1 Medical Electrical Equipment, Part 1: General Requirements for Safety...

  10. Nutrition knowledge and nutritional status of primary school children ...

    African Journals Online (AJOL)

    2010-01-04

    Jan 4, 2010 ... b Research Fellow, CSL, Vaal University of Technology, South Africa ... Keywords: primary school children; nutrition knowledge; nutritional status. Nutrition ... research on basic nutrition education focusing on adolescents has.

  11. Laboratory Tests

    Science.gov (United States)

    ... Video Series in French, German & Spanish USIDNET Visiting Immunology Scholars USIDNET Travel Grants for Faculty and Fellows ... Find Resources for You I am a Recent Articles Raising PI Awareness at a Newly Opened CSL ...

  12. Quality assurance plan for the Close Support Laboratory for the remedial investigation at Oak Ridge National Laboratory, Oak Ridge, Tennessee

    International Nuclear Information System (INIS)

    1993-08-01

    The primary purpose of the Close Support Laboratory (CSL) is to provide rapid radiological screening of investigation-derived samples before they are shipped to off-site laboratories for more detailed analyses. Analyses for volatile organic compounds and miscellaneous water quality parameters are also performed at the CSL. CSL data are also used to select samples for off-site laboratory analysis, for rapid qualitative and quantitative determinations, and for other processes when off-site analysis is not needed and/or is impractical. This plan specifies methods of implementing analytical and radiological protocols and procedures for the documentation, handling, control, and analysis of samples and describes the levels of authority and responsibility for laboratory operation. Specific quality control methods used by the CSL for individual analyses are described in project procedures

  13. Electroluminescence enhancement for near-ultraviolet light emitting diodes with graphene/AZO-based current spreading layers

    DEFF Research Database (Denmark)

    Lin, Li; Ou, Yiyu; Zhu, Xiaolong

    LEDs) have attracted significant research interest due to their intensive applications in various areas where indium tin oxide (ITO) is one of the most widely employed transparent conductive materials for NUV LEDs. Compared to ITO, indium-free aluminum-doped zinc oxide (AZO) has similar electrical......Near-ultraviolet light emitting diodes with different aluminum-doped zinc oxide-based current spreading layers were fabricated and electroluminescence (EL) was compared. A 170% EL enhancement was achieved by using a graphene-based interlayer. GaN-based near-ultraviolet light emitting diodes (NUV...... with a new type of current spreading layer (CSL) which combines AZO and a single-layer graphene (SLG) as an effective transparent CSL [1]. In the present work, LEDs with solo AZO CSL in Fig.1(a) and SLG/Ni/AZO-based CSL in Fig.1(b) were both fabricated for EL comparison. Standard mesa fabrication including...

  14. Dicty_cDB: CHO775 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available WMLKGRPGRCPTCK--- ---EGNMIENQYITLKTKLTPT**r*csl*nlgrlccq*sr*ti*nqylcsrysft*ere *k*tfhslgkr*e*itlmaw**vn*frid...sft*ere *k*tfhslgkr*e*itlmaw**vn*fridclagikncsticsknwlqiw*rylfc*ly** iiqllfhik*lsnctyvim*sftw*he*iet*ylygrgt

  15. Dicty_cDB: AHB310 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available *k*tfhslgkr*e*itlmaw**vn*fridclagikncsticsknwlqiw*rylfc*ly* *iiqllfhik*lsnctyvim*sftw*he*iet*ylygrgttsip*yks...csl*nlgrlccq*sr*ti*nqylcsrysft*er e*k*tfhslgkr*e*itlmaw**vn*fridclagikncsticsknwl

  16. Dicty_cDB: CHN167 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available q*sr*ti*nqylcsrysft*ere* k*tfhslgkr*e*itlmaw**vn*fridclagikncsticsknwlqiw*rylfc*ly**i iqllfhik*lsnctyvim*sft...*csl*nlgrlccq*sr*ti*nqylcsrysft*ere* k*tfhslgkr*e*itlmaw**vn*fridclagikncsticsknw

  17. Dicty_cDB: CHO739 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available t*ere* k*tfhslgkr*e*itlmaw**vn*fridclagikncsticsknwlqiw*rylfc*ly**i iqllfhik*lsnctyvim*sftw*he*iet*ylygrgtts...YITLKTKLTPT**r*csl*nlgrlccq*sr*ti*nqylcsrysft*ere* k*tfhslgkr*e*itlmaw**vn*fridclagikncsticsknwlqiw*rylfc*ly

  18. Production of thermophilic and acidophilic endoglucanases by ...

    African Journals Online (AJOL)

    Production of thermophilic and acidophilic endoglucanases by mutant Trichoderma atroviride 102C1 using agro-industrial by-products. ... The effect of the carbon (sugarcane bagasse: SCB) and nitrogen (corn steep liquor: CSL) sources on ...

  19. Arabidopsis CDS blastp result: AK242585 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK242585 J090010M20 At3g03050.1 68416.m00301 cellulose synthase family protein (CslD3) similar to cellulose... synthase catalytic subunit gi:2827143 from [Arabidopsis thaliana], cellulose syntha

  20. Arabidopsis CDS blastp result: AK242601 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK242601 J090014G03 At3g03050.1 68416.m00301 cellulose synthase family protein (CslD3) similar to cellulose... synthase catalytic subunit gi:2827143 from [Arabidopsis thaliana], cellulose syntha

  1. Arabidopsis CDS blastp result: AK110467 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK110467 002-166-G08 At3g03050.1 cellulose synthase family protein (CslD3) similar to cellulose... synthase catalytic subunit gi:2827143 from [Arabidopsis thaliana], cellulose synthase-7 (gi:962

  2. Arabidopsis CDS blastp result: AK242890 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK242890 J090079L19 At3g03050.1 68416.m00301 cellulose synthase family protein (CslD3) similar to cellulose... synthase catalytic subunit gi:2827143 from [Arabidopsis thaliana], cellulose syntha

  3. Responding to Environmental Challenges in Central Asia and the Caspian Basin

    National Research Council Canada - National Science Library

    Hughes, Edward

    2001-01-01

    ...), the Center for Strategic Leadership (CSL) of the U.S. Army War College, and the George C. Marshall European Center for Security Studies, and hosted by the Marshall Center in Garmisch-Partenkirchen, Germany...

  4. The Collins Center Update. Volume 1, Issue 3, December 1999

    National Research Council Canada - National Science Library

    Harvey, Kevin; Wasiak, Joe; Kievit, James; Griffard, B. F; Blotzer, Larry

    1999-01-01

    ...: Kentucky Governor Patton Kicks Off the Center for Strategic Leadership's (CSL) Senior Executive Program, Global Guardian Exercise '99, Global Wargame '99, Democratization Initiatives Support Simulation, Deterrence in the 21st Century Symposium...

  5. Casa Santos Lima : from “Business as Usual” to “Expand”

    OpenAIRE

    Sabido, João Oliveira da Silva

    2016-01-01

    The case study aims to evaluate the strategy formulation of Casa Santos Lima (CSL), a Portuguese wine company, whose profile and competitive business were very useful to discuss and recommend overall strategic priorities that should guide CLS’s development and overcome with success rather challenging times ahead. From a traditional wine farm located in Alenquer, in the denominated wine producer area of Lisbon, CSL implemented a philosophy of management based on high quality ...

  6. Quantifying benefits and risks of vaccinating Australian children aged six months to four years with trivalent inactivated seasonal influenza vaccine in 2010.

    Science.gov (United States)

    Kelly, H; Carcione, D; Dowse, G; Effler, P

    2010-09-16

    Australian and New Zealand health authorities identified seasonal trivalent inactivated influenza vaccines manufactured by CSL Biotherapies as the probable cause of increased febrile convulsions in children under five within 24 hours of vaccination and recommended against their use in this age group. We quantified the benefit-risk profile of the CSL vaccines using the number needed to vaccinate and suggest they might have caused two to three hospital admissions due to febrile convulsions for every hospital admission due to influenza prevented.

  7. Optimization of a corn steep medium for production of ethanol from synthesis gas fermentation by Clostridium ragsdalei.

    Science.gov (United States)

    Saxena, Jyotisna; Tanner, Ralph S

    2012-04-01

    Fermentation of biomass derived synthesis gas to ethanol is a sustainable approach that can provide more usable energy and environmental benefits than food-based biofuels. The effects of various medium components on ethanol production by Clostridium ragsdalei utilizing syngas components (CO:CO(2)) were investigated, and corn steep liquor (CSL) was used as an inexpensive nutrient source for ethanol production by C. ragsdalei. Elimination of Mg(2+), NH(4) (+) and PO(4) (3-) decreased ethanol production from 38 to 3.7, 23 and 5.93 mM, respectively. Eliminating Na(+), Ca(2+), and K(+) or increasing Ca(2+), Mg(2+), K(+), NH(4) (+) and PO(4) (3-) concentrations had no effect on ethanol production. However, increased Na(+) concentration (171 mM) inhibited growth and ethanol production. Yeast extract (0.5 g l(-1)) and trace metals were necessary for growth of C. ragsdalei. CSL alone did not support growth and ethanol production. Nutrients limiting in CSL were trace metals, NH(4) (+) and reducing agent (Cys: cysteine sulfide). Supplementation of trace metals, NH(4) (+) and CyS to CSL (20 g l(-1), wet weight basis) yielded better growth and similar ethanol production as compared to control medium. Using 10 g l(-1), the nutritional limitation led to reduced ethanol production. Higher concentrations of CSL (50 and 100 g l(-1)) were inhibitory for cell growth and ethanol production. The CSL could replace yeast extract, vitamins and minerals (excluding NH(4) (+)). The optimized CSL medium produced 120 and 50 mM of ethanol and acetate, respectively. The CSL could provide as an inexpensive source of most of the nutrients required for the syngas fermentation, and thus could improve the economics of ethanol production from biomass derived synthesis gas by C. ragsdalei.

  8. Ultrasound Assisted Synthesis of Hydroxylated Soybean Lecithin from Crude Soybean Lecithin as an Emulsifier.

    Science.gov (United States)

    Chiplunkar, Pranali P; Pratap, Amit P

    2017-10-01

    Soybean lecithin is a by-product obtained during degumming step of crude soybean oil refining. Crude soybean lecithin (CSL) contains major amount of phospholipids (PLs) along with minor amount of acylglycerols, bioactive components, etc. Due to presence of PLs, CSL can be used as an emulsifier. Crude soybean lecithin (CSL) was utilized to synthesize hydroxylated soybean lecithin (HSL) by hydroxylation using hydrogen peroxide and catalytic amount of lactic acid to enhance the hydrophilicity and emulsifying properties of CSL. To reduce the reaction time and to increase rate of reaction, HSL was synthesized under ultrasound irradiation. The effect of different operating parameters such as lactic acid, hydrogen peroxide, temperature, ultrasonic power and duty cycle in synthesis of HSL were studied and optimized. The surface tension (SFT), interfacial tension (IFT) and the critical micelle concentration (CMC) of the HSL (26.11 mN/m, 2.67 mN/m, 112 mg/L) were compared to CSL (37.53 mN/m, 6.22 mN/m, 291 mg/L) respectively. The HSL has better emulsion stability and low foaming characteristics as compared to CSL. Therefore, the product as an effective emulsifier can be used in food, pharmacy, lubricant, cosmetics, etc.

  9. Hardness prediction of HAZ in temper bead welding by non-consistent layer technique

    International Nuclear Information System (INIS)

    Yu, Lina; Saida, Kazuyoshi; Mochizuki, Masahito; Kameyama, Masashi; Chigusa, Naoki; Nishimoto, Kazutoshi

    2014-01-01

    Based on the experimentally obtained hardness database, the neural network-based hardness prediction system of heat affect zone (HAZ) in temper bead welding by Consistent Layer (CSL) technique has been constructed by the authors. However in practical operation, CSL technique is sometimes difficult to perform because of difficulty of the precise heat input controlling, and in such case non-CSL techniques are mainly used in the actual repair process. Therefore in the present study, the neural network-based hardness prediction system of HAZ in temper bead welding by non-CSL techniques has been constructed through thermal cycle simplification, from the view of engineering. The hardness distribution in HAZ with non-CSL techniques was calculated based on the thermal cycles numerically obtained by finite element method. The experimental result has shown that the predicted hardness is in good accordance with the measured ones. It follows that the currently proposed method is effective for estimating the tempering effect during temper bead welding by non-CSL techniques. (author)

  10. What are driving the long-term Caspian Sea level change?

    Science.gov (United States)

    Chen, J.

    2017-12-01

    Caspian Sea level (CSL) has undergone substantial fluctuations during the past several hundred years. The causes over the entire historical period are uncertain, but we investigate here large changes seen in the past several decades. We use climate model predicted precipitation (P), evaporation (E), and observed river runoff (R) to reconstruct long-term CSL changes for 1979-2015, and show that PER (P-E+R) flux predictions agree very well with observed CSL changes. The observed rapid CSL increase (about 12.74 cm/yr) and significant drop ( -6.72 cm/yr) during the periods 1979-1995 and 1996-2015 are well accounted for by integrated PER flux predictions of +12.38 and -6.79 cm/yr, respectively. We show that increased evaporation rates over the Caspian Sea play a dominant role in reversing the increasing trend in CSL during the past 37 years. The current long-term decline in CSL is expected to continue into the foreseeable future, under global warming scenarios.

  11. Nurturing social responsibility through community service-learning: Lessons learned from a pilot project.

    Science.gov (United States)

    Dharamsi, Shafik; Espinoza, Nancy; Cramer, Carl; Amin, Maryam; Bainbridge, Lesley; Poole, Gary

    2010-01-01

    Community service-learning (CSL) has been proposed as one way to enrich medical and dental students' sense of social responsibility toward people who are marginalized in society. We developed and implemented a new CSL option in the integrated medical/dental curriculum and assessed its educational impact. Focus groups, individual open-ended interviews, and a survey were used to assess dental students', faculty tutors' and community partners' experiences with CSL. CSL enabled a deeper appreciation for the vulnerabilities that people who are marginalized experience; students gained a greater insight into the social determinants of health and the related importance of community engagement; and they developed useful skills in health promotion project planning, implementation and evaluation. Community partners and faculty tutors indicated that equal partnership, greater collaboration, and a participatory approach to course development are essential to sustainability in CSL. CSL can play an important role in nurturing a purposeful sense of social responsibility among future practitioners. Our study enabled the implementation of an innovative longitudinal course (professionalism and community service) in all 4 years of the dental curriculum.

  12. Cricket Club

    CERN Multimedia

    Cricket Club

    2012-01-01

    Bern CC V CERN CC in Bern on Sunday 6th May 2012 The storm clouds gathered over Switzerland this weekend as a CERN XI travelled more in hope than expectation to Bern for our first league game of the season. Despite the gloomy weather forecast the sun shone and Captain Elvin won the toss and put Bern into bat on a damp, soft and tricky wicket. Early success came as D'Mello had the Bern captain caught by D. Ahmed in his second over. This was to prove the only success in the first 20 overs as BERN made light of the pitch and the CERN attack to go into the drinks break on 108-1. CERN came storming out after the break with Elvin making the breakthrough to dismiss the Bern number 2 for 74. D'Mello then came back into the attack and ended up with 4-34 as CERN held their catches and fielded well. Chauduri was in fine form and stormed in to take 3-27. Elvin was tight and economical until he went for 23 in his final over but D. Ahmed mopped up the tail with 2-16 in a fine 4 over spell. CERN...

  13. Plaadid / Valner Valme

    Index Scriptorium Estoniae

    Valme, Valner, 1970-

    2003-01-01

    Heliplaatide "Higha Collection 3", "My Big Fat Greek Wedding", Apocalyptica "Reflections", The Raveonettes "Whip It On", Kaunimate Vennaskond "Kaunimad astad su elus", Led Zeppelin "Early Days& Latter Days", "The Heart And SAoul Of Bert Berns", Groove Armanda "Love Box" tutvustus

  14. Genetics Home Reference: 15q13.3 microdeletion

    Science.gov (United States)

    ... GW, Spence JE, Amato S, Rousseau JA, Moghaddam B, Skinner C, Skinner SA, Bernes S, Armstrong N, Shinawi M, Stankiewicz P, ... Sharp AJ, Mefford HC, Li K, Baker C, Skinner C, Stevenson RE, Schroer RJ, Novara F, De ...

  15. [Karin Hallas. Das Tallinner Mietshaus. Vom Historismus bis zum Jugendstil] / Paul Kaegbein

    Index Scriptorium Estoniae

    Kaegbein, Paul

    2006-01-01

    Arvustus: Karin Hallas. Das Tallinner Mietshaus. Vom Historismus bis zum Jugendstil. In: Architektur und bildende Kunst im Baltikum um 1900. Frankfurt am Main, Berlin, Bern, Bruxelles, New York, Wien: Lang 1999. S. 173-192.

  16. Nova libro pri interlingvistiko

    Index Scriptorium Estoniae

    2006-01-01

    Rets rmt.: Blanke, Detlev. Interlinguistische Beiträge : zum Wesen und zur Plansprachen / herausgegeben von Sabine Fiedler. Frankfurt/Main, Berlin ; Bern ; Bruxelles ; New York ; Oxford ; Wien : Europäischer Verlag der Wissenschaften Peter Lang

  17. In Situ Pre-Selection of Return Samples with Bio-Signatures by Combined Laser Mass Spectrometry and Optical Microscopy

    Science.gov (United States)

    Wiesendanger, R.; Wurz, P.; Tulej, M.; Wacey, D.; Neubeck, A.; Grimaudo, V.; Riedo, A.; Moreno, P.; Cedeño-López, A.; Ivarsson, M.

    2018-04-01

    The University of Bern developed instrument prototypes that allow analysis of samples on Mars prior to bringing them back to Earth, allowing to maximize the scientific outcome of the returned samples. We will present the systems and first results.

  18. Kunstikriitik Ants Juske sai doktoriks / Neeme Korv

    Index Scriptorium Estoniae

    Korv, Neeme, 1974-

    2003-01-01

    Tartu Kõrgema Kunstikooli rektor Ants Juske kaitses 7. veebruaril Tallinnas Kunstiakadeemias edukalt doktoriväitekirja, juhendajaks oli professor Boris Bernštein ning oponeerisid doktor Altti Kuusamo Soomest ja professor Peeter Tulviste

  19. A majority in favour of the construction of further nuclear power stations

    International Nuclear Information System (INIS)

    Anon.

    1978-01-01

    The results of an opinion poll of 5000 German-speaking persons in Bern Canton, Switzerland are summarised and commented on. 54% of those questioned expressed approval of further nuclear power station construction in Switzerland. (F.Q.)

  20. If Hunters End Up in the Emergency Room: A Retrospective Analysis of Hunting Injuries in a Swiss Emergency Department

    OpenAIRE

    Bestetti, Valentina; Fisher, Emma E.; Srivastava, David S.; Ricklin, Meret E.; Exadaktylos, Aristomenis K.

    2015-01-01

    Aim. to characterize the mechanisms, patterns, and outcomes of nonfatal hunting-related injuries in patients presenting to Bern University Hospital, Switzerland, and compare these to reports of hunting injuries worldwide. Methods. patients presenting with hunting-related injuries to the Emergency Department at Bern University hospital from 2000 to 2014 were identified by retrospectively searching the department database using the keyword “hunt.” Each case was analyzed in terms of the patient...

  1. The presentation of energy topics at exhibitions

    International Nuclear Information System (INIS)

    Moergeli, H.P.

    1984-01-01

    The author examines the problems confronting an electricity supply company when trying to communicate its energy policy to the general public at exhibitions and fairs. The company has to convey a message of reliable power supplies, increasing demand, the advantages of nuclear energy, the safe storage of radioactive waste and the need for new generating plants. The author describes some of the displays being used to attract the public to the Bern Power Stations stand at the Bern Exhibition 1984. (R.S.)

  2. Rate Processes in Dissipative Systems: 50 Years After Kramers, Discussion Meeting Held in Tutzing (Germany, F.R.) on 10-13 September 1990

    Science.gov (United States)

    1990-09-13

    Chem. Soc., Faraday Trans. [5] S. T. Abdel-Halim, M. H. Abdel-Kader, and U. E. Steiner , J. 2, 83, 1941 (1987), Phys. Chem 92, 4324 (1988). [29] W...December 5th, 1990) Zusammensetzung, Eigenschaften und Anwendungen Mesomorpher Tensidphasen RUDOLF HEUSCH Leverkusen, Paul-Klee-StraBe 85 (Received on...Institut f~r Anorganisehe Chemnie der Universitiit Rudower Chaussee 5, 0-1199 Physikalisehe Chemie) Rudolf - Bern, Freie Stra~e 3, CH-3000 Bern, be- Berlin

  3. Impact of gestational weight gain and prepregnancy body mass index on the prevalence of large-for-gestational age infants in two cohorts of women with type 1 insulin-dependent diabetes: a cross-sectional population study

    Science.gov (United States)

    Bowers, Katherine; Dolan, Lawrence M; Deka, Ranjan; Jackson, Chandra L; Khoury, Jane C

    2018-01-01

    Objectives Despite improvements in treatment modalities, large-for-gestational age (LGA) prevalence has remained between 30% and 40% among infants of mothers with type 1 insulin-dependent diabetes mellitus (TIDM). Our objective was to estimate LGA prevalence and examine the association between gestational weight gain (GWG) and prepregnancy body mass index (BMI) with LGA among mothers with TIDM. Design Cross-sectional study. Setting Regional data in Cincinnati, Ohio, from the Diabetes in Pregnancy Program Project (PPG), a prospective cohort for the period 1978–1993; national data from Consortium on Safe Labor (CSL), a multicentre cross-sectional study for the period 2002–2008. Participants The study included 333 pregnancies in the PPG and 358 pregnancies in the CSL. Pregnancies delivered prior to 23 weeks’ gestation were excluded. Women with TIDM in the PPG were identified according to physician confirmation of ketoacidosis, and/or c-peptide levels, and by International Classification of Diseases, ninth version codes within the CSL. LGA was identified as birth weight >90th percentile according to gestational age, race and sex. Main outcome measures LGA at birth. Results Mean±SD maternal age at delivery was 26.4±5.1 years for PPG women and 27.5±6.0 years for CSL women, p=0.008. LGA prevalence did not significantly differ between cohorts (PPG: 40.2% vs CSL: 36.6%, p=0.32). More women began pregnancy as overweight in the later cohort (PPG (16.8%) vs CSL (27.1%), pIOM) guidelines was higher in the later CSL (56.2%) vs PPG (42.3%) cohort, pIOM guidelines had a lower LGA prevalence in CSL (PPG: 30.6% vs CSL: 13.7%), p=0.001. Conclusions Normal-weight women with GWG within IOM guidelines experienced a lower LGA prevalence, supporting the importance of adherence to IOM guidelines for GWG to reduce LGA. High BMI and GWG may be hindering a reduction in LGA prevalence. PMID:29602844

  4. Stereolithographic processing of ceramics: Photon diffusion in colloidal dispersion

    Science.gov (United States)

    Garg, Rajeev

    The technique of ceramic stereolithography (CSL) has been developed for fabricating near net shape ceramic objects. In stereolithography, the three-dimensional computer design file of the object is sliced into thin layers. Each layer is physically fabricated by photocuring the surface of a liquid photo-polymerizable resin bath by raster scanning an ultra-violet laser across the surface of the resin. In CSL, the liquid resin is a high concentration colloidal dispersion in a solution of ultraviolet curable polymers. The ceramic green body fabricated by ceramic stereolithography technique is subjected to the post processing steps of drying, binder burnout and sintering to form a dense ceramic object. An aqueous alumina dispersion in photocuring polymers with particle volume fraction greater than 0.5 was formulated for CSL process. Low molecular weight solution polymers were found to be best suited for formulating ceramic resins due to their inherently low viscosity and favorable interactions with the ceramic dispersant. A hydroxyapatite ceramic resin was also developed for the use in the CSL technique. A model is developed to describe the photocuring process in concentrated ceramic dispersion. The curing profile in ceramic dispersion is governed by multiple scattering from the ceramic particles and absorption by the photocuring polymers. Diffusion theory of light transport is used to model the multiple scattering and absorption phenomena. It is found that diffusive transport adequately describes the phenomena of laser pulse propagation in highly concentrated colloidal dispersions. A model was developed to describe the absorption in highly concentrated ceramic dispersion. Various complex-shaped monolithic alumina and hydroxyapatite objects were fabricated by CSL and shown to possess uniform microstructure. The mechanical properties and sintering behavior of the parts fabricated by CSL are shown to be comparable to those fabricated by other ceramic processing technique

  5. Effect of Chum Salmon Egg Lectin on Tight Junctions in Caco-2 Cell Monolayers

    Directory of Open Access Journals (Sweden)

    Ryo Nemoto

    2015-05-01

    Full Text Available The effect of a chum salmon egg lectin (CSL3 on tight junction (TJ of Caco-2 cell monolayers was investigated. The lectin opened TJ as indicated by the decrease of the transepithelial electrical resistance (TER value and the increase of the permeation of lucifer yellow, which is transported via the TJ-mediated paracellular pathway. The effects of CSL3 were inhibited by the addition of 10 mM L-rhamnose or D-galactose which were specific sugars for CSL3. The lectin increased the intracellular Ca2+ of Caco-2 cell monolayers, that could be inhibited by the addition of L-rhamnose. The fluorescence immunostaining of β-actin in Caco-2 cell monolayers revealed that the cytoskeleton was changed by the CSL3 treatment, suggesting that CSL3 depolymerized β-actin to cause reversible TJ structural and functional disruption. Although Japanese jack bean lectin and wheat germ lectin showed similar effects in the decrease of the TER values and the increase of the intracellular Ca2+, they could not be inhibited by the same concentrations of simple sugars, such as D-glucose and N-acetyl-D-glucosamine.

  6. Walking the bridge: Nursing students' learning in clinical skill laboratories.

    Science.gov (United States)

    Ewertsson, Mona; Allvin, Renée; Holmström, Inger K; Blomberg, Karin

    2015-07-01

    Despite an increasing focus on simulation as a learning strategy in nursing education, there is limited evidence on the transfer of simulated skills into clinical practice. Therefore it's important to increase knowledge of how clinical skills laboratories (CSL) can optimize students' learning for development of professional knowledge and skills, necessary for quality nursing practice and for patient safety. Thus, the aim was to describe nursing students' experiences of learning in the CSL as a preparation for their clinical practice. Interviews with 16 students were analysed with content analysis. An overall theme was identified - walking the bridge - in which the CSL formed a bridge between the university and clinical settings, allowing students to integrate theory and practice and develop a reflective stance. The theme was based on categories: conditions for learning, strategies for learning, tension between learning in the skills laboratory and clinical settings, and development of professional and personal competence. The CSL prepared the students for clinical practice, but a negative tension between learning in CSL and clinical settings was experienced. However, this tension may create reflection. This provides a new perspective that can be used as a pedagogical approach to create opportunities for students to develop their critical thinking. Copyright © 2015 Elsevier Ltd. All rights reserved.

  7. Caspian Sea level changes during the last millennium: historical and geological evidences from the south Caspian Sea

    Science.gov (United States)

    Naderi Beni, A.; Lahijani, H.; Mousavi Harami, R.; Arpe, K.; Leroy, S. A. G.; Marriner, N.; Berberian, M.; Andrieu-Ponel, V.; Djamali, M.; Mahboubi, A.

    2013-03-01

    Historical literature may constitute a valuable source of information to reconstruct sea level changes. Here, historical documents and geological records have been combined to reconstruct Caspian sea-level (CSL) changes during the last millennium. In addition to a literature survey, new data from two short sediment cores were obtained from the south-eastern Caspian coast to identify coastal change driven by water-level changes. Two articulated bivalve shells from the marine facies were radiocarbon dated and calibrated to establish a chronology and to compare them with historical findings. The overall results indicate a high-stand during the Little Ice Age, up to -19 m, with a -28 m low-stand during the Medieval Climate Anomaly, while presently the CSL stands at -26.5 m. A comparison of the CSL curve with other lake systems and proxy records suggests that the main sea-level oscillations are essentially paced by solar irradiance. Although the major controller of the long-term CSL changes is driven by climatological factors, the seismicity of the basin could create locally changes in base level. These local base-level changes should be considered in any CSL reconstruction.

  8. Caspian sea-level changes during the last millennium: historical and geological evidence from the south Caspian Sea

    Science.gov (United States)

    Naderi Beni, A.; Lahijani, H.; Mousavi Harami, R.; Arpe, K.; Leroy, S. A. G.; Marriner, N.; Berberian, M.; Andrieu-Ponel, V.; Djamali, M.; Mahboubi, A.; Reimer, P. J.

    2013-07-01

    Historical literature may constitute a valuable source of information to reconstruct sea-level changes. Here, historical documents and geological records have been combined to reconstruct Caspian sea-level (CSL) changes during the last millennium. In addition to a comprehensive literature review, new data from two short sediment cores were obtained from the south-eastern Caspian coast to identify coastal change driven by water-level changes and to compare the results with other geological and historical findings. The overall results indicate a high-stand during the Little Ice Age, up to -21 m (and extra rises due to manmade river avulsion), with a -28 m low-stand during the Medieval Climate Anomaly, while presently the CSL stands at -26.5 m. A comparison of the CSL curve with other lake systems and proxy records suggests that the main sea-level oscillations are essentially paced by solar irradiance. Although the major controller of the long-term CSL changes is driven by climatological factors, the seismicity of the basin creates local changes in base level. These local base-level changes should be considered in any CSL reconstruction.

  9. Concentrate supplementation strategies in ryegrass pasture for productive performance in lambs

    International Nuclear Information System (INIS)

    Santos, S.K.; Falbo, M.K.; Sandini, I.E.; Pacentchuk, F.; Neumann, M.; Garbossa, G.

    2018-01-01

    This study evaluated the effect of two concentrate supplementation strategies on performance, metabolic profile and economic evaluation of suckling lambs and ewes in ryegrass (Lolium multiflorum) pasture. Twenty-seven ewes and 45 lambs were divided into three groups: (1) ryegrass pasture without supplementation - control (CON); (2) CON plus supplemented ewes and lambs at 1% of live weight (SEL), and (3) CON plus creep feeding supplemented lambs at 1% of live weight (CSL). Concentrate use increased (p<0.05) average daily gain (ADG) by 19.95% over CON (21.6 and 18.3% for SEL and CSL, respectively). Concentrate use contributed to minimizing forage quality fluctuation and provided greater ADG stability, mainly when ryegrass nutritional content and digestibility decreased. Blood metabolites profiles did not differ between groups, with exception of phosphorus which was higher for CON than SEL, and calcium which was higher for CSL than CON (p<0.05). Compared to CON, stoking rate values were greater to SEL (p<0.05). Compared to CSL, ewe and total stocking rate were greater (p<0.05) to SEL. Considering the control group as break even feed investment, SEL strategy had a positive economic return, while CSL showed economic losses. Concentrate use increased ADG of lambs and decrease the impact of nutrient quality changes of forage on daily gains, but must be considered that supplemental strategy used could affect negatively economic return.

  10. On-site laboratory support of Oak Ridge National Laboratory environmental restoration field activities

    International Nuclear Information System (INIS)

    Burn, J.L.E.

    1995-07-01

    A remedial investigation/feasibility study has been undertaken at Oak Ridge National Laboratory (ORNL). Bechtel National, Inc. and partners CH2M Hill, Ogden Environmental and Energy Services, and PEER Consultants are contracted to Lockheed Martin Energy Systems, performing this work for ORNL's Environmental Restoration (ER) Program. An on-site Close Support Laboratory (CSL) established at the ER Field Operations Facility has evolved into a laboratory where quality analytical screening results can be provided rapidly (e.g., within 24 hours of sampling). CSL capabilities include three basic areas: radiochemistry, chromatography, and wet chemistry. Radiochemical analyses include gamma spectroscopy, tritium and carbon-14 screens using liquid scintillation analysis, and gross alpha and beta counting. Cerenkov counting and crown-ether-based separation are the two rapid methods used for radiostrontium determination in water samples. By extending count times where appropriate, method detection limits can match those achieved by off-site contract laboratories. Volatile organic compounds are detected by means of gas chromatography using either headspace or purge and trap sample introduction (based on EPA 601/602). Ionic content of water samples is determined using ion chromatography and alkalinity measurement. Ion chromatography is used to quantify both anions (based on EPA 300) and cations. Wet chemistry procedures performed at the CSL include alkalinity, pH (water and soil), soil resistivity, and dissolved/suspended solids. Besides environmental samples, the CSL routinely screens health and safety and waste management samples. The cost savings of the CSL are both direct and indirect

  11. Evolution of grain boundary character distributions in alloy 825 tubes during high temperature annealing: Is grain boundary engineering achieved through recrystallization or grain growth?

    International Nuclear Information System (INIS)

    Bai, Qin; Zhao, Qing; Xia, Shuang; Wang, Baoshun; Zhou, Bangxin; Su, Cheng

    2017-01-01

    Grain boundary engineering (GBE) of nickel-based alloy 825 tubes was carried out with different cold drawing deformations by using a draw-bench on a factory production line and subsequent annealing at various temperatures. The microstructure evolution of alloy 825 during thermal-mechanical processing (TMP) was characterized by means of the electron backscatter diffraction (EBSD) technique to study the TMP effects on the grain boundary network and the evolution of grain boundary character distributions during high temperature annealing. The results showed that the proportion of ∑ 3 n coincidence site lattice (CSL) boundaries of alloy 825 tubes could be increased to > 75% by the TMP of 5% cold drawing and subsequent annealing at 1050 °C for 10 min. The microstructures of the partially recrystallized samples and the fully recrystallized samples suggested that the proportion of low ∑ CSL grain boundaries depended on the annealing time. The frequency of low ∑ CSL grain boundaries increases rapidly with increasing annealing time associating with the formation of large-size highly-twinned grains-cluster microstructure during recrystallization. However, upon further increasing annealing time, the frequency of low ∑ CSL grain boundaries decreased markedly during grain growth. So it is concluded that grain boundary engineering is achieved through recrystallization rather than grain growth. - Highlights: •The grain boundary engineering (GBE) is applicable to 825 tubes. •GBE is achieved through recrystallization rather than grain growth. •The low ∑ CSL grain boundaries in 825 tubes can be increased to > 75%.

  12. Chitosan produced from Mucorales fungi using agroindustrial by-products and its efficacy to inhibit Colletotrichum species.

    Science.gov (United States)

    Ramos Berger, Lúcia Raquel; Montenegro Stamford, Thayza Christina; de Oliveira, Kataryne Árabe Rimá; de Miranda Pereira Pessoa, Adjane; de Lima, Marcos Antonio Barbosa; Estevez Pintado, Maria Manuela; Saraiva Câmara, Marcos Paz; de Oliveira Franco, Luciana; Magnani, Marciane; de Souza, Evandro Leite

    2018-03-01

    This study evaluated corn steep liquor (CSL) and papaya peel juice (PPJ) in mixture as substrates for the cultivation (96h, 28°C, pH 5.6, 150rpm) of Mucorales fungi for chitosan production, and determined the growth-inhibitory effect of the fungal chitosan (FuCS) obtained under optimized conditions against phytopathogenic Colletotrichum species. All Mucorales fungi tested were capable of growing in CSL-PPJ medium, showing FuCS production in the range of 5.02 (Fennelomyces heterothalicus SIS 28) - 15.63mg/g (Cunninghamella elegans SIS 41). Highest FuCS production (37.25mg/g) was achieved when C. elegans was cultivated in medium containing 9.43% CSL and 42.5% PPJ. FuCS obtained under these conditions showed a deacetylation degree of 86%, viscosity of 120cP and molecular weight of 4.08×10 4 g/mol. FuCS at 5000, 7500 and 10,000ppm inhibited the growth of all Colletotrichum species tested. FuCS also induced alterations in the morphology of C. fructicola hyphae. CSL-PPJ mixtures are suitable substrates for the cultivation of Mucorales fungi for FuCS production. Chitosan from C. elegans cultivated in CSL-PPJ medium is effective in inhibiting phytopathogenic Colletotrichum species. Copyright © 2017 Elsevier B.V. All rights reserved.

  13. Dual Mechanism of Interleukin-3 Receptor Blockade by an Anti-Cancer Antibody

    Directory of Open Access Journals (Sweden)

    Sophie E. Broughton

    2014-07-01

    Full Text Available Interleukin-3 (IL-3 is an activated T cell product that bridges innate and adaptive immunity and contributes to several immunopathologies. Here, we report the crystal structure of the IL-3 receptor α chain (IL3Rα in complex with the anti-leukemia antibody CSL362 that reveals the N-terminal domain (NTD, a domain also present in the granulocyte-macrophage colony-stimulating factor (GM-CSF, IL-5, and IL-13 receptors, adopting unique “open” and classical “closed” conformations. Although extensive mutational analyses of the NTD epitope of CSL362 show minor overlap with the IL-3 binding site, CSL362 only inhibits IL-3 binding to the closed conformation, indicating alternative mechanisms for blocking IL-3 signaling. Significantly, whereas “open-like” IL3Rα mutants can simultaneously bind IL-3 and CSL362, CSL362 still prevents the assembly of a higher-order IL-3 receptor-signaling complex. The discovery of open forms of cytokine receptors provides the framework for development of potent antibodies that can achieve a “double hit” cytokine receptor blockade.

  14. Graphene interlayer for current spreading enhancement by engineering of barrier height in GaN-based light-emitting diodes.

    Science.gov (United States)

    Min, Jung-Hong; Son, Myungwoo; Bae, Si-Young; Lee, Jun-Yeob; Yun, Joosun; Maeng, Min-Jae; Kwon, Dae-Gyeon; Park, Yongsup; Shim, Jong-In; Ham, Moon-Ho; Lee, Dong-Seon

    2014-06-30

    Pristine graphene and a graphene interlayer inserted between indium tin oxide (ITO) and p-GaN have been analyzed and compared with ITO, which is a typical current spreading layer in lateral GaN LEDs. Beyond a certain current injection, the pristine graphene current spreading layer (CSL) malfunctioned due to Joule heat that originated from the high sheet resistance and low work function of the CSL. However, by combining the graphene and the ITO to improve the sheet resistance, it was found to be possible to solve the malfunctioning phenomenon. Moreover, the light output power of an LED with a graphene interlayer was stronger than that of an LED using ITO or graphene CSL. We were able to identify that the improvement originated from the enhanced current spreading by inspecting the contact and conducting the simulation.

  15. Effects of a highly Si-doped GaN current spreading layer at the n+-GaN/multi-quantum-well interface on InGaN/GaN blue-light-emitting diodes

    International Nuclear Information System (INIS)

    Kim, C. S.; Cho, H. K.; Choi, R. J.; Hahn, Y. B.; Lee, H. J.; Hong, C. H.

    2004-01-01

    Highly Si-doped GaN thin current spreading layer (CSL) with various carrier concentrations were inserted before the n + -GaN/multi-quantum-well (MQW) interface controlled by the growth rate and the modulated Si-doping in InGaN/GaN blue light-emitting diodes (LEDs), and their effects were investigated by using capacitance-voltage (C-V), current-voltage (I-V), and output power measurements. The LEDs with a highly Si-doped CSL show enhanced I-V characteristics and increased output power with increasing carrier concentration up to some critical point in the CSL. This means that proper high Si-doping in some limited area before the interface may enhance the device performance through the current spreading effect.

  16. A trace-based model for multiparty contracts

    DEFF Research Database (Denmark)

    Hvitved, Tom; Klaedtke, Felix; Zălinescu, Eugen

    2012-01-01

    In this article we present a model for multiparty contracts in which contract conformance is defned abstractly as a property on traces. A key feature of our model is blame assignment, which means that for a given contract, every breach is attributed to a set of parties. We show that blame...... assignment is compositional by de¿ning contract conjunction and contract disjunction. Moreover, to specify real-world contracts, we introduce the contract speci¿cation language CSL with an operational semantics. We show that each CSL contract has a counterpart in our trace-based model and from...... the operational semantics we derive a run-time monitor. CSL overcomes limitations of previously proposed formalisms for specifying contracts by supporting: (history sensitive and conditional) commitments, parametrised contract templates, relative and absolute temporal constraints, potentially in¿nite contracts...

  17. Static and dynamical anomalies caused by chiral soliton lattice in molecular-based chiral magnets

    International Nuclear Information System (INIS)

    Kishine, Jun-ichiro; Inoue, Katsuya; Kikuchi, Koichi

    2007-01-01

    Interplay of crystallographic chirality and magnetic chirality has been of great interest in both chemist's and physicist's viewpoints. Crystals belonging to chiral space groups are eligible to stabilize macroscopic chiral magnetic order. This class of magnetic order is described by the chiral XY model, where the transverse magnetic field perpendicular to the chiral axis causes the chiral soliton lattice (CSL) formation. As a clear evidence of the chiral magnetic order, the temperature dependence of the transverse magnetization exhibits sharp cusp just below the mean field ferrimagnetic transition temperature, indicating the formation of the CSL. In addition to the static anomaly, we expect the CSL formation also causes dynamical anomalies such as induction of the spin supercurrent

  18. CsI electromagnetic calorimeter development for a low or medium energy e+e- collider

    International Nuclear Information System (INIS)

    King, M.E.

    1993-10-01

    Design considerations for an electromagnetic Csl calorimeter suitable for use at low and medium energy, high-luminosity e + e - storage rings are presented, together with results of a test of an array of Csl(Tl) crystals in an e - /π - beam (120 to 400 MeV) at TRIUMF. The crystal array used in the test was designed to explore longitudinal and transverse crystal segmentation, and a redundant wavelength-shifter and photodiode readout system. Energy resolution of (1.69 ± 0.08)%/√E and (1.83 ± 0.05)%/√E was obtained for two different crystal tower configurations. Position resolution of 6.5 (9.0) mm was obtained at 300 (120)MeV for four 4x4 cm 2 , 4 rl. Csl crystals

  19. A radiolabeled antibody targeting CD123+ leukemia stem cells – initial radioimmunotherapy studies in NOD/SCID mice engrafted with primary human AML

    Directory of Open Access Journals (Sweden)

    Jeffrey V. Leyton

    2015-01-01

    Full Text Available Radioimmunotherapy (RIT with anti-CD123 monoclonal antibody CSL360 modified with nuclear translocation sequence (NLS peptides and labeled with the Auger electron-emitter, 111In (111In-NLS-CSL360 was studied in the prevalent NOD/SCID mouse AML engraftment assay. Significant decreases in CD123+ leukemic cells and impairment of leukemic stem cell self-renewal were achieved with high doses of RIT. However, NOD/SCID mice were very radiosensitive to these doses. At low non-toxic treatment doses, 111In-NLS-CSL360 demonstrated a trend towards improved survival associated with decreased spleen/body weight ratio, an indicator of leukemia burden, and almost complete eradication of leukemia from the bone marrow in some mice.

  20. Single-flavour and two-flavour pairing in three-flavour quark matter

    International Nuclear Information System (INIS)

    Alford, Mark G; Cowan, Greig A

    2006-01-01

    We study single-flavour quark pairing ('self-pairing') in colour-superconducting phases of quark matter, paying particular attention to the difference between scenarios where all three flavours undergo single-flavour pairing, and scenarios where two flavours pair with each other ('2SC' pairing) and the remaining flavour self-pairs. We perform our calculations in the mean-field approximation using a pointlike four-fermion interaction based on single gluon exchange. We confirm the result from previous weakly-coupled-QCD calculations that when all three flavours self-pair the favoured channel for each is colour-spin-locked (CSL) pseudoisotropic pairing. However, we find that when the up and down quarks undergo 2SC pairing, they induce a colour chemical potential that disfavours the CSL phase. The strange quarks then self-pair in a 'polar' channel that breaks rotational invariance, although the CSL phase may survive in a narrow range of densities

  1. Molecular epidemiology of Cryptosporidium spp. and Giardia spp. in mussels (Mytilus californianus) and California sea lions (Zalophus californianus) from Central California.

    Science.gov (United States)

    Adell, A D; Smith, W A; Shapiro, K; Melli, A; Conrad, P A

    2014-12-01

    Cryptosporidium and Giardia are of public health importance, with recognized transmission through recreational waters. Therefore, both can contaminate marine waters and shellfish, with potential to infect marine mammals in nearshore ecosystems. A 2-year study was conducted to evaluate the presence of Cryptosporidium and Giardia in mussels located at two distinct coastal areas in California, namely, (i) land runoff plume sites and (ii) locations near sea lion haul-out sites, as well as in feces of California sea lions (CSL) (Zalophus californianus) by the use of direct fluorescent antibody (DFA) detection methods and PCR with sequence analysis. In this study, 961 individual mussel hemolymph samples, 54 aliquots of pooled mussel tissue, and 303 CSL fecal samples were screened. Giardia duodenalis assemblages B and D were detected in hemolymph from mussels collected near two land runoff plume sites (Santa Rosa Creek and Carmel River), and assemblages C and D were detected in hemolymph from mussels collected near a sea lion haul-out site (White Rock). These results suggest that mussels are being contaminated by protozoa carried in terrestrial runoff and/or shed in the feces of CSL. Furthermore, low numbers of oocysts and cysts morphologically similar to Cryptosporidium and Giardia, respectively, were detected in CSL fecal samples, suggesting that CSL could be a source and a host of protozoan parasites in coastal environments. The results of this study showed that Cryptosporidium and Giardia spp. from the feces of terrestrial animals and CSL can contaminate mussels and coastal environments. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

  2. Does the cranial suspensory ligament have a role in cryptorchidism?

    Science.gov (United States)

    Kassim, Normadiah M; Russell, D A; Payne, A P

    2010-01-01

    The cranial suspensory ligament (CSL) is a fibromuscular structure anchoring the embryonic gonad to the posterior abdominal wall in male and female mammals. Its persistence in females is believed to be responsible for retaining the ovaries within the abdomen, while its regression in males permits testis descent. Embryonic loss of the CSL in males is believed to be an androgen-dependent event, and failure of this process has been proposed as a cause of cryptorchidism. The present study demonstrates that the nuclei of mesenchymal cells in the caudal part of the CSL are immunoreactively positive for androgen receptor. We examined the effects of exposure of the non-steroidal antiandrogen flutamide during the period from gestational day 10 to birth on the development of the CSL and on testis descent. Exposure of male Albino Swiss rats to the antiandrogen flutamide during this period resulted in feminization of the external genitalia and the suppression of growth of the testes and male reproductive tracts. In adulthood, testes were found to be located in diverse positions including normal scrotal (50%), intra-abdominal (10%) and ectopic suprainguinal (40%). The CSL of the testis persisted into adulthood in all flutamide-treated males, regardless of testis location. In all cases, the ligament consisted of bundles of smooth muscle fibres in the retroperitoneal fat of the posterior abdominal wall. These findings suggest that androgen blockade during embryonic development interferes with testicular descent, but that maldescent cannot be correlated with either the persistence of the CSL of the testis or its structure.

  3. Latitudinal range influences the seasonal variation in the foraging behavior of marine top predators.

    Directory of Open Access Journals (Sweden)

    Stella Villegas-Amtmann

    Full Text Available Non-migratory resident species should be capable of modifying their foraging behavior to accommodate changes in prey abundance and availability associated with a changing environment. Populations that are better adapted to change will have higher foraging success and greater potential for survival in the face of climate change. We studied two species of resident central place foragers from temperate and equatorial regions with differing population trends and prey availability associated to season, the California sea lion (Zalophus californianus (CSL whose population is increasing and the endangered Galapagos sea lion (Zalophus wollebaeki (GSL whose population is declining. To determine their response to environmental change, we studied and compared their diving behavior using time-depth recorders and satellite location tags and their diet by measuring C and N isotope ratios during a warm and a cold season. Based on latitudinal differences in oceanographic productivity, we hypothesized that the seasonal variation in foraging behavior would differ for these two species. CSL exhibited greater seasonal variability in their foraging behavior as seen in changes to their diving behavior, foraging areas and diet between seasons. Conversely, GSL did not change their diving behavior between seasons, presenting three foraging strategies (shallow, deep and bottom divers during both. GSL exhibited greater dive and foraging effort than CSL. We suggest that during the warm and less productive season a greater range of foraging behaviors in CSL was associated with greater competition for prey, which relaxed during the cold season when resource availability was greater. GSL foraging specialization suggests that resources are limited throughout the year due to lower primary production and lower seasonal variation in productivity compared to CSL. These latitudinal differences influence their foraging success, pup survival and population growth reflected in

  4. Impact of the European Russia drought in 2010 on the Caspian Sea level

    Directory of Open Access Journals (Sweden)

    K. Arpe

    2012-01-01

    Full Text Available The hydrological budgets of the Volga basin (VB and the Caspian Sea (CS have been analysed. The components of the water balance for the CS were calculated for the period 1993 to 2010 with emphasis on summer 2010 when a severe drought developed over European Russia.

    A drop in precipitation over the VB in July 2010 occurs simultaneously with a decrease in evaporation for the same area, an increase of evaporation over the CS itself and a drop of the Caspian Sea level (CSL. The drop in the precipitation over the VB cannot lead to an instantaneous drop of the CSL because the precipitated water needs some months to reach the CS. The delay is estimated here to be 1 to 3 months for excessive precipitation in summer, longer for deficient precipitation and for winter cases. However, the evaporation over the CS itself is considered to be responsible for a simultaneous drop of the CSL from July to September 2010. The impact on the CSL from the precipitation deficit over the VB occurs in the months following the drought. The water deficit from July to September 2010 calculated from the anomalous precipitation minus evaporation over the VB would decrease the CSL by 22 cm, of which only 2 cm had been observed until the end of September (observed Volga River discharge anomaly. So the remaining drop of 20 cm can be expected in the months to follow if no other anomalies happen. In previous studies the precipitation over the VB has been identified as the main cause for CSL changes, but here from a 10 cm drop from beginning of July to end of September, 6 cm can be directly assigned to the enhanced evaporation over the CS itself and 2 cm due to reduced precipitation over the CS.

    Further periods with strong changes of the CSL are also investigated, which provide some estimates concerning the accuracy of the analysis data. The investigation was possible due to the new ECMWF interim reanalysis data which are used to provide data also for sensitive

  5. Behaviour of radionuclides in biological and non-biological processes at very low concentrations

    International Nuclear Information System (INIS)

    Sinnaeve, J.; Frissel, M.J.; Klugt, N. van der; Geijn, S.C. van de.

    1980-01-01

    Four experiments using a 'biological exchange column', i.e. a cut papyrus stem were carried out. Prior to the passage of the labelled solution containing 250 μCi 137 Cs.l -1 , and 1 μCi 134 Cs.l -1 , the exchange sites of the stem were protonated. Two treatments were carried out, the first with 10 -4 M stable caesium in the labelled solution and the second with 10 -4 M potassium. After detection of the front of activity half way up the stem, 5 cm segments of the stem were cut and counted. (Auth.)

  6. Constant scattering length fits to low energy K-p interactions

    International Nuclear Information System (INIS)

    Conboy, J.E.

    1985-10-01

    The paper concerns the data on low energy K - p interactions analysed using the constant scattering length (C.S.L.) approximation. The scattering lengths are found to differ significantly from those required to fit data from previous K -1 p experiments, and these differences are discussed. The data indicate an Tspin=1 P- wave interaction, from the production angle distributions of the K-bar 0 n, Σ +- π -+ and Λπ 0 channels. However the authors have been unable to fit both the P-wave and K 0 sub(L)p data with the simple C.S.L. model. (U.K.)

  7. The 2008 IDA Cost Research Workshop: Contractor Data Reporting Systems

    Science.gov (United States)

    2008-07-01

    Consulting Services, Ltd. Mr. Michael Carey, NCCA, (703) 692-4901 Mr. Craig Clark, HVR CSL, 011 44 1420 87977 Ms Mary M. Mertz, NSWC-CD, (301) 227-4012...Services, Ltd Mr. Michael Carey, NCCA, (703) 692-4901 Mr. Craig Clark, HVR CSL, 011 44 1420 87977 Ms Mary M. Mertz, NSWC-CD, (301) 227-4012... Deegan , (202) 781-0959 Size: Professional: 57 Support: 2 Consultants: 0 Subcontractors: 9 collocated or 30 total Focus: O&S Cost Estimating

  8. Program scheme using common source lines in channel stacked NAND flash memory with layer selection by multilevel operation

    Science.gov (United States)

    Kim, Do-Bin; Kwon, Dae Woong; Kim, Seunghyun; Lee, Sang-Ho; Park, Byung-Gook

    2018-02-01

    To obtain high channel boosting potential and reduce a program disturbance in channel stacked NAND flash memory with layer selection by multilevel (LSM) operation, a new program scheme using boosted common source line (CSL) is proposed. The proposed scheme can be achieved by applying proper bias to each layer through its own CSL. Technology computer-aided design (TCAD) simulations are performed to verify the validity of the new method in LSM. Through TCAD simulation, it is revealed that the program disturbance characteristics is effectively improved by the proposed scheme.

  9. The Bernese Emigration to the United States, 1870–1930: A Quantitative Analysis of Economic Factors

    Directory of Open Access Journals (Sweden)

    Simon Geissbühler

    1999-10-01

    Full Text Available The United States was the most important destination for emigrants from the Swiss canton of Bern during the period of mass emigration in the late 19th and the early 20th century. The present article looks at the economic factors leading to this mass emigration. Using bivariate correlations, this study demonstrates that quantitative analysis is a powerful tool in historical emigration research. The data underlines the two following theses. First, the better the economy in Bern, the lower the rate of emigration to the United States. Secondly, the better the economy in the United States, the higher the rate of emigration from Bern. Hence, both pull and push factors played an important role determining emigration from Bern to the United States. The most closely related to the rate of emigration were the independent variables emigration to the USA in year t-1, the investments in structural engineering in Bern, railroad construction in the USA and the number of Bernese on welfare. The results clearly show that Bernese emigration was primarily a socio-economic mass movement.

  10. Three-Dimensional Evolution of Erupted Flux Ropes from the Sun (2-20 Solar Radii) to 1 AU

    Science.gov (United States)

    2012-12-01

    public release; distribution unlimited 13. SUPPLEMENTARY NOTES Preprint, Solar Phys., 2013 14. ABSTRACT 15. SUBJECT TERMS 16. SECURITY ...NASA GSFC (USA), RAL and University of Birmingham (UK), MPS(Germany), CSL (Belgium), IOTA and IAS (France). References Brueckner, G.E., Howard, R.A

  11. The Temperature-Dependent Nature of Coronal Dimmings

    Science.gov (United States)

    2010-07-01

    opening-up, of flux and can be observed both off-limb and on-disk. 15. SUBJECT TERMS 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT...international consortium of the NRL, LMSAL and NASA GSFC (USA), RAL and U. Bham (UK), MPS (Germany), CSL (Belgium), IOTA and IAS (France). This work was

  12. The Longitudinal Properties of a Solar Energetic Particle Event Investigated Using Modern Solar Imaging

    Science.gov (United States)

    2012-06-10

    and white light) and the longitudinal extent of the SEP event in the heliosphere. 15. SUBJECT TERMS 16. SECURITY CLASSIFICATION OF: 17. LIMITATION...The STEREO SECCHI data are pro- duced by a consortium of RAL (UK), NRL (USA), LMSAL (USA), GSFC (USA), MPS (Germany), CSL (Belgium), IOTA (France

  13. Tracking Streamer Blobs Into the Heliosphere

    Science.gov (United States)

    2010-05-20

    SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT Same as Report (SAR) 18. NUMBER OF PAGES 10 19a. NAME OF RESPONSIBLE PERSON a. REPORT...NASA/GSFC (US), RAL (UK), UB- HAM (UK), MPS (Germany), CSL (Belgium), IOTA (France), and IAS (France). In the US, funding was provided by NASA, in the

  14. Characterizing the reduction of stimulation artifact noise in a tripolar nerve cuff electrode by application of a conductive shield layer.

    Science.gov (United States)

    Sabetian, Parisa; Sadeghlo, Bita; Zhang, Chengran Harvey; Yoo, Paul B

    2017-02-01

    Tripolar nerve cuff electrodes have been widely used for measuring peripheral nerve activity. However, despite the high signal-to-noise ratio levels that can be achieved with this recording configuration, the clinical use of cuff electrodes in closed-loop controlled neuroprostheses remains limited. This is largely attributed to artifact noise signals that contaminate the recorded neural activity. In this study, we investigated the use of a conductive shield layer (CSL) as a means of reducing the artifact noise recorded by nerve cuff electrodes. Using both computational simulations and in vivo experiments, we found that the CSL can result in up to an 85% decrease in the recorded artifact signal. Both the electrical conductivity and the surface area of the CSL were identified as important design criteria. Although this study shows that the CSL can significantly reduce artifact noise in tripolar nerve cuff electrodes, long-term implant studies are needed to validate our findings. Copyright © 2016 IPEM. Published by Elsevier Ltd. All rights reserved.

  15. The Role of Radical Awareness in Chinese-As-A-Second-Language Learners' Chinese Character Reading Development

    Science.gov (United States)

    Wong, Yu Ka

    2017-01-01

    In this paper, the role of radical awareness in Chinese character reading development among young Chinese-as-a-second-language (CSL) learners is evaluated in terms of a structural property of the writing system: the distribution of elementary, one-radical (i.e. one-element) simple characters as against majority, multi-radical compound characters.…

  16. Tableau Calculus for the Logic of Comparative Similarity over Arbitrary Distance Spaces

    Science.gov (United States)

    Alenda, Régis; Olivetti, Nicola

    The logic CSL (first introduced by Sheremet, Tishkovsky, Wolter and Zakharyaschev in 2005) allows one to reason about distance comparison and similarity comparison within a modal language. The logic can express assertions of the kind "A is closer/more similar to B than to C" and has a natural application to spatial reasoning, as well as to reasoning about concept similarity in ontologies. The semantics of CSL is defined in terms of models based on different classes of distance spaces and it generalizes the logic S4 u of topological spaces. In this paper we consider CSL defined over arbitrary distance spaces. The logic comprises a binary modality to represent comparative similarity and a unary modality to express the existence of the minimum of a set of distances. We first show that the semantics of CSL can be equivalently defined in terms of preferential models. As a consequence we obtain the finite model property of the logic with respect to its preferential semantic, a property that does not hold with respect to the original distance-space semantics. Next we present an analytic tableau calculus based on its preferential semantics. The calculus provides a decision procedure for the logic, its termination is obtained by imposing suitable blocking restrictions.

  17. Spintronic logic design methodology based on spin Hall effect–driven magnetic tunnel junctions

    International Nuclear Information System (INIS)

    Kang, Wang; Zhang, Youguang; Zhao, Weisheng; Wang, Zhaohao; Klein, Jacques-Olivier; Lv, Weifeng

    2016-01-01

    Conventional complementary metal-oxide-semiconductor (CMOS) technology is now approaching its physical scaling limits to enable Moore’s law to continue. Spintronic devices, as one of the potential alternatives, show great promise to replace CMOS technology for next-generation low-power integrated circuits in nanoscale technology nodes. Until now, spintronic memory has been successfully commercialized. However spintronic logic still faces many critical challenges (e.g. direct cascading capability and small operation gain) before it can be practically applied. In this paper, we propose a standard complimentary spintronic logic (CSL) design methodology to form a CMOS-like logic design paradigm. Using the spin Hall effect (SHE)-driven magnetic tunnel junction (MTJ) device as an example, we demonstrate CSL implementation, functionality and performance. This logic family provides a unified design methodology for spintronic logic circuits and partly solves the challenges of direct cascading capability and small operation gain in the previously proposed spintronic logic designs. By solving a modified Landau–Lifshitz–Gilbert equation, the magnetization dynamics in the free layer of the MTJ is theoretically described and a compact electrical model is developed. With this electrical model, numerical simulations have been performed to evaluate the functionality and performance of the proposed CSL design. Simulation results demonstrate that the proposed CSL design paradigm is rather promising for low-power logic computing. (paper)

  18. Removal of nitrogen by a layered soil infiltration system during intermittent storm events.

    Science.gov (United States)

    Cho, Kang Woo; Song, Kyung Guen; Cho, Jin Woo; Kim, Tae Gyun; Ahn, Kyu Hong

    2009-07-01

    The fates of various nitrogen species were investigated in a layered biological infiltration system under an intermittently wetting regime. The layered system consisted of a mulch layer, coarse soil layer (CSL), and fine soil layer (FSL). The effects of soil texture were assessed focusing on the infiltration rate and the removal of inorganic nitrogen species. The infiltration rate drastically decreased when the uniformity coefficient was larger than four. The ammonium in the synthetic runoff was shown to be removed via adsorption during the stormwater dosing and nitrification during subsequent dry days. Stable ammonium adsorption was observed when the silt and clay content of CSL was greater than 3%. This study revealed that the nitrate leaching was caused by nitrification during dry days. Various patterns of nitrate flushing were observed depending on the soil configuration. The washout of nitrate was more severe as the silt/clay content of the CSL was greater. However, proper layering of soil proved to enhance the nitrate removal. Consequently, a strictly sandy CSL over FSL with a silt and clay content of 10% was the best configuration for the removal of ammonium and nitrate.

  19. Anomalous electrodynamics of neutral pion matter in strong magnetic fields

    Energy Technology Data Exchange (ETDEWEB)

    Brauner, Tomáš [Department of Mathematics and Natural Sciences, University of Stavanger,N-4036 Stavanger (Norway); Kadam, Saurabh V. [Indian Institute of Science Education and Research (IISER),Pune 411008 (India)

    2017-03-03

    The ground state of quantum chromodynamics in sufficiently strong external magnetic fields and at moderate baryon chemical potential is a chiral soliton lattice (CSL) of neutral pions https://arxiv.org/abs/1609.05213. We investigate the interplay between the CSL structure and dynamical electromagnetic fields. Our main result is that in presence of the CSL background, the two physical photon polarizations and the neutral pion mix, giving rise to two gapped excitations and one gapless mode with a nonrelativistic dispersion relation. The nature of this mode depends on the direction of its propagation, interpolating between a circularly polarized electromagnetic wave https://www.doi.org/10.1103/PhysRevD.93.085036 and a neutral pion surface wave, which in turn arises from the spontaneously broken translation invariance. Quite remarkably, there is a neutral-pion-like mode that remains gapped even in the chiral limit, in seeming contradiction to the Goldstone theorem. Finally, we have a first look at the effect of thermal fluctuations of the CSL, showing that even the soft nonrelativistic excitation does not lead to the Landau-Peierls instability. However, it leads to an anomalous contribution to pressure that scales with temperature and magnetic field as T{sup 5/2}(B/f{sub π}){sup 3/2}.

  20. Jordan (α,β-Derivations on Operator Algebras

    Directory of Open Access Journals (Sweden)

    Quanyuan Chen

    2017-01-01

    Full Text Available Let A be a CSL subalgebra of a von Neumann algebra acting on a Hilbert space H. It is shown that any Jordan (α,β-derivation on A is an (α,β-derivation, where α,β are any automorphisms on A. Moreover, the nth power (α,β-maps on A are investigated.

  1. An Analysis of Gender and Major Differences upon Undergraduate Student Attitudes about Community Service Learning

    Science.gov (United States)

    Shukla, P. K.; Shukla, Monica P.

    2014-01-01

    Community Service Learning (CSL) believes that university and colleges should incorporate community based service projects into courses. There are faculty and administrator supporters who argue for such proposals to require community service learning components into classes, but there are also faculty and administrator critics of such proposals.…

  2. Dicty_cDB: VHM584 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ti*nqylcsrysft*er e*k*tfhslgkr*e*itlmaw**vn*fridclagikncsticsknwlqiw*rylfc*ly* *iiqllfhik*lsnctyvim*sftw*he*...GRCPTCKNFDILFNGI EYQCKGWISGFTKCDWKGDSIER--- ---LEGNMIENQYITLKTQTHST**r*csl*nlgrlccq*sr*ti*nqylcsrysft*er e*k...*tfhslgkr*e*itlmaw**vn*fridclagikncsticsknwlqiw*rylfc*ly* *iiqllfhik*lsnctyvim*sftw*he*iet*ylygrgttsip*yksfr

  3. Dicty_cDB: CHI483 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available lccq*sr*ti*nqylcsry sft*ere*k*tfhslgkr*e*itlmaw**vn*fridclagikncsticsknwlqiw*ryl fc*ly**iiqllfhik*lsnctyvim*...ENQYITLKTKLTPT**r*csl*nlgrlccq*sr*ti*nqylcsry sft*ere*k*tfhslgkr*e*itlmaw**vn*fridclagikncsticsknwlqiw*ryl f

  4. Dicty_cDB: SHF852 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available re*k*tfhslgkr*e*itlmaw**vn*fridclagikncsticsknwlqiw*ry lfc*ly**iiqllfhik*lsnctyvim*sftw*he*iet*ylygrgttsip*y...sfkk*ipfnf*if--- ---LRSKLNPLEGNMIENQYITLKNQTHST**r*csl*nxgrlccq*sr*ti*nqylcsr ysft*ere*k*tfhslgkr*e*itlmaw**vn*frid

  5. A Markov reward model checker

    NARCIS (Netherlands)

    Katoen, Joost P.; Maneesh Khattri, M.; Zapreev, I.S.; Zapreev, I.S.

    2005-01-01

    This short tool paper introduces MRMC, a model checker for discrete-time and continuous-time Markov reward models. It supports reward extensions of PCTL and CSL, and allows for the automated verification of properties concerning long-run and instantaneous rewards as well as cumulative rewards. In

  6. Model Checking Markov Reward Models with Impulse Rewards

    NARCIS (Netherlands)

    Cloth, Lucia; Katoen, Joost-Pieter; Khattri, Maneesh; Pulungan, Reza; Bondavalli, Andrea; Haverkort, Boudewijn; Tang, Dong

    This paper considers model checking of Markov reward models (MRMs), continuous-time Markov chains with state rewards as well as impulse rewards. The reward extension of the logic CSL (Continuous Stochastic Logic) is interpreted over such MRMs, and two numerical algorithms are provided to check the

  7. Reduction in Rotavirus-associated Acute Gastroenteritis Following Introduction of Rotavirus Vaccine Into Australia's National Childhood Vaccine Schedule

    NARCIS (Netherlands)

    Buttery, Jim P.; Lambert, Stephen B.; Grimwood, Keith; Nissen, Michael D.; Field, Emma J.; Macartney, Kristine K.; Akikusa, Jonathan D.; Kelly, Julian J.; Kirkwood, Carl D.

    Introduction: Rotavirus vaccines were introduced into the funded Australian National Immunization Program (NIP) in July 2007. Due to purchasing arrangements, individual states and territories chose either a 2-dose RV1 (Rotarix, GSK) regimen or 3-dose RV5 (Rotateq, Merck/CSL) regimen. This allowed

  8. Students‟ reflections on the attainment of competencies in a ...

    African Journals Online (AJOL)

    Community service-learning (CSL) is advocated as a pedagogical tool to impart knowledge, attitudes and skills to students. This study aimed at determining whether community service-learning was a suitable method of instruction for recreation students to acquire the competencies needed in the field. Competencies ...

  9. Download this PDF file

    African Journals Online (AJOL)

    Formative assessment, through the provision of feedback and debriefing in the simulated ... depends upon effective teaching, assessment and feedback[9] in the CSL setting. These skills are .... The research design involved mixing both ..... assessment. Moreover, establishing an instructional system and revising the clinical.

  10. Predicting Trophic Interactions and Habitat Utilization in the California Current Ecosystem

    Science.gov (United States)

    2015-09-30

    Foraging patterns: model-data comparison . Simulated (colored circles) and observed (black circles) foraging locations for male sea lion individuals off...focusing on trophic interactions affecting habitat utilization and foraging patterns of California sea lions (CSL) in the California Current Large Marine...by considering patterns of covariability between environmental variables (e.g., temperature, primary production) and foraging patterns and success of

  11. A Computer Oriented Scheme for Coding Chemicals in the Field of Biomedicine.

    Science.gov (United States)

    Bobka, Marilyn E.; Subramaniam, J.B.

    The chemical coding scheme of the Medical Coding Scheme (MCS), developed for use in the Comparative Systems Laboratory (CSL), is outlined and evaluated in this report. The chemical coding scheme provides a classification scheme and encoding method for drugs and chemical terms. Using the scheme complicated chemical structures may be expressed…

  12. Model Checking Structured Infinite Markov Chains

    NARCIS (Netherlands)

    Remke, Anne Katharina Ingrid

    2008-01-01

    In the past probabilistic model checking hast mostly been restricted to finite state models. This thesis explores the possibilities of model checking with continuous stochastic logic (CSL) on infinite-state Markov chains. We present an in-depth treatment of model checking algorithms for two special

  13. Studies on the antimicrobial effect of corn steep liquor on some ...

    African Journals Online (AJOL)

    ROFIAT

    2014-01-08

    Jan 8, 2014 ... The antimicrobial effect of Corn Steep Liquor (CSL) was investigated over a five day period. The pH and titrable acidity of the liquor were determined, while the antimicrobial effect on some diarrhoea causing organisms such as Escherichia coli, Salmonella enteriditis, Staphylococcus aureus and Vibrio.

  14. Third-year medical students' and clinical teachers' perceptions of ...

    African Journals Online (AJOL)

    Background. Clinical skills training in the clinical skills laboratory (CSL) environment forms an important part of the undergraduate medical curriculum. These skills are better demonstrated than described. A lack of direct observation and feedback given to medical students performing these skills has been reported. Without ...

  15. Investigating Mobile-Assisted Oral Feedback in Teaching Chinese as a Second Language

    Science.gov (United States)

    Xu, Qi; Peng, Hongying

    2017-01-01

    This article reports on an exploratory study investigating mobile-assisted oral feedback in teaching Chinese as a second language (CSL). It is aimed at exploring the characteristics of mobile-assisted feedback on oral production with the smartphone social communication app WeChat as a case in point and examining learners' perceptions of…

  16. A systematic analysis of backbone amide assignments achieved via combinatorial selective labelling of amino acids

    Energy Technology Data Exchange (ETDEWEB)

    Jeremy Craven, C. [University of Sheffield, Department of Biotechnology and Molecular Biology (United Kingdom); Al-Owais, Moza; Parker, Martin J. [University of Leeds, Astbury Centre for Structural Molecular Biology, Institute of Molecular and Cellular Biology (United Kingdom)], E-mail: m.j.parker@leeds.ac.uk

    2007-06-15

    With the advent of high-yield cell-free expressions systems, many researchers are exploiting selective isotope labelling of amino acids to increase the efficiency and accuracy of the NMR assignment process. We developed recently a combinatorial selective labelling (CSL) method capable of yielding large numbers of residue-type and sequence-specific backbone amide assignments, which involves comparing cross-peak intensities in {sup 1}H-{sup 15}N HSQC and 2D {sup 1}H-{sup 15}N HNCO spectra collected for five samples containing different combinations of {sup 13}C- and {sup 15}N-labelled amino acids [Parker MJ, Aulton-Jones M, Hounslow A, Craven C J (2004) J Am Chem Soc 126:5020-5021]. In this paper we develop a robust method for establishing the reliability of these assignments. We have performed a detailed statistical analysis of the CSL data collected for a model system (the B1 domain of protein G from Streptococcus), developing a scoring method which allows the confidence in assignments to be assessed, and which enables the effects of overlap on assignment fidelity to be predicted. To further test the scoring method and also to assess the performance of CSL in relation to sample quality, we have applied the method to the CSL data collected for GFP in our previous study.

  17. The Influence of Anode Inner Contour on Atmospheric DC Plasma Spraying Process

    Directory of Open Access Journals (Sweden)

    Kui Wen

    2017-01-01

    Full Text Available In thermal plasma spraying process, anode nozzle is one of the most important components of plasma torch. Its inner contour controls the characteristics of plasma arc/jet, determining the motion and heating behaviors of the in-flight particles and hence influencing the coating quality. In this study, the effects of anode inner contour, standard cylindrical nozzle, and cone-shaped Laval nozzle with conical shape diverging exit (CSL nozzle on the arc voltage, net power, thermal efficiency, plasma jet characteristics, in-flight particle behaviors, and coating properties have been systematically investigated under atmospheric plasma spraying conditions. The results show that the cylindrical nozzle has a higher arc voltage, net power, and thermal efficiency, as well as the higher plasma temperature and velocity at the torch exit, while the CSL nozzle has a higher measured temperature of plasma jet. The variation trends of the plasma jet characteristics for the two nozzles are comparable under various spraying parameters. The in-flight particle with smaller velocity of CSL nozzle has a higher measured temperature and melting fraction. As a result, the coating density and adhesive strength of CSL nozzle are lower than those of cylindrical nozzle, but the deposition efficiency is greatly improved.

  18. Decree nr 2017-1271 of 9 August 2017 bearing publication of the agreement under the form of an exchange of letters between the Government of the French Republic and the Swiss Federal Council concerning the scope and modalities of alert and/or transmission of information in case of minor event or accidental situation in the French Bugey nuclear plant or in the Swiss Beznau, Goegen, Leibstadt and Muehleberg nuclear plants (together an appendix) signed in Bern on 22 February 2017 and in Bourg-en-Bresse on 28 March 2017

    International Nuclear Information System (INIS)

    Macron, Emmanuel; Philippe, Edouard; Le Drian, Jean-Yves; Cochet, Arnaud; Buehlmann, Benno

    2017-01-01

    After the decree text which formalises the implementation of the agreement between France and Switzerland about alert and information modalities in case of minor events or accidental situations occurring in French and Swiss nuclear power plants located near the border, this document contains the agreement text which specifies these modalities, notably by specifying involved public bodies and authorities in charge of implementation of these modalities in the different concerned cases (minor event, accidental situation), and actions these bodies and authorities are supposed to undertake in terms of reciprocal information

  19. The effects of antecedent dry days on the nitrogen removal in layered soil infiltration systems for storm run-off control.

    Science.gov (United States)

    Cho, Kang-Woo; Yoon, Min-Hyuk; Song, Kyung-Guen; Ahn, Kyu-Hong

    2011-01-01

    The effects of antecedent dry days (ADD) on nitrogen removal efficiency were investigated in soil infiltration systems, with three distinguishable layers: mulch layer (ML), coarse soil layer (CSL) and fine soil layer (FSL). Two sets of lab-scale columns with loamy CSL (C1) and sandy CSL (C2) were dosed with synthetic run-off, carrying chemical oxygen demand of 100 mg L(-1) and total nitrogen of 13 mg L(-1). The intermittent dosing cycle was stepwise adjusted for 5, 10 and 20 days. The influent ammonium and organic nitrogen were adsorbed to the entire depth in C1, while dominantly to the FSL in C2. In both columns, the effluent ammonium concentration increased while the organic nitrogen concentration decreased, as ADD increased from 5 to 20 days. The effluent of C1 always showed nitrate concentration exceeding influent, caused by nitrification, by increasing amounts as ADD increased. However, the wash-out of nitrate in C1 was not distinct in terms of mass since the effluent flow rate was only 25% of the influent. In contrast, efficient reduction (>95%) of nitrate loading was observed in C2 under ADD of 5 and 10 days, because of insignificant nitrification in the CSL and denitrification in the FSL. However, for the ADD of 20 days, a significant nitrate wash-out appeared in C2 as well, possibly because of the re-aeration by the decreasing water content in the FSL. Consequently, the total nitrogen load escaping with the effluent was always smaller in C2, supporting the effectiveness of sandy CSL over loamy FSL for nitrogen removal under various ADDs.

  20. Structure-function analysis of RBP-J-interacting and tubulin-associated (RITA) reveals regions critical for repression of Notch target genes.

    Science.gov (United States)

    Tabaja, Nassif; Yuan, Zhenyu; Oswald, Franz; Kovall, Rhett A

    2017-06-23

    The Notch pathway is a cell-to-cell signaling mechanism that is essential for tissue development and maintenance, and aberrant Notch signaling has been implicated in various cancers, congenital defects, and cardiovascular diseases. Notch signaling activates the expression of target genes, which are regulated by the transcription factor CSL (CBF1/RBP-J, Su(H), Lag-1). CSL interacts with both transcriptional corepressor and coactivator proteins, functioning as both a repressor and activator, respectively. Although Notch activation complexes are relatively well understood at the structural level, less is known about how CSL interacts with corepressors. Recently, a new RBP-J (mammalian CSL ortholog)-interacting protein termed RITA has been identified and shown to export RBP-J out of the nucleus, thereby leading to the down-regulation of Notch target gene expression. However, the molecular details of RBP-J/RITA interactions are unclear. Here, using a combination of biochemical/cellular, structural, and biophysical techniques, we demonstrate that endogenous RBP-J and RITA proteins interact in cells, map the binding regions necessary for RBP-J·RITA complex formation, and determine the X-ray structure of the RBP-J·RITA complex bound to DNA. To validate the structure and glean more insights into function, we tested structure-based RBP-J and RITA mutants with biochemical/cellular assays and isothermal titration calorimetry. Whereas our structural and biophysical studies demonstrate that RITA binds RBP-J similarly to the RAM (RBP-J-associated molecule) domain of Notch, our biochemical and cellular assays suggest that RITA interacts with additional regions in RBP-J. Taken together, these results provide molecular insights into the mechanism of RITA-mediated regulation of Notch signaling, contributing to our understanding of how CSL functions as a transcriptional repressor of Notch target genes. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  1. The Swiss national network for isotopes in the hydrological cycle

    International Nuclear Information System (INIS)

    Schotterer, U.

    1998-01-01

    The network is based on the long-term stations of the Climate and Environmental Physics Group and includes 11 precipitation, 6 river and 3 ground water stations. For the isotope measurements the Universities of Bern (Climate and Environmental Physics Group, tritium and oxygen-18) and Lausanne (Institute for Mineralogy and Petrography, deuterium) are contracted on a year to year basis. Sampling instructions, collection and shipment of samples are within the responsibility of the Bern group. The sampling apart from monthly composites of precipitation includes also samples from surface and ground water. The isotope data are available by contacting the Swiss Hydrological and Geological Survey directly

  2. Long-term oxygen therapy in COPD patients: population-based cohort study on mortality

    Directory of Open Access Journals (Sweden)

    Pavlov N

    2018-03-01

    Full Text Available Nikolay Pavlov,1 Alan Gary Haynes,2,3 Armin Stucki,4 Peter Jüni,5 Sebastian Robert Ott1 1Department of Pulmonary Medicine, University Hospital (Inselspital, University of Bern, Bern, Switzerland; 2CTU Bern, University of Bern, Bern, Switzerland; 3Institute of Social and Preventive Medicine (ISPM, University of Bern, Bern, Switzerland; 4Department of Internal Medicine, Spital Thun, Thun, Switzerland; 5Applied Health Research Centre, Li Ka Shing Knowledge Institute of St Michael’s Hospital, Department of Medicine, University of Toronto, Toronto, ON, Canada Purpose: Chronic obstructive pulmonary disease (COPD is the fourth leading cause of death worldwide and is associated with a growing and substantial socioeconomic burden. Long-term oxygen therapy (LTOT, recommended by current treatment guidelines for COPD patients with severe chronic hypoxemia, has shown to reduce mortality in this population. The aim of our study was to assess the standardized mortality ratios of incident and prevalent LTOT users and to identify predictors of mortality. Patients and methods: We conducted a 2-year follow-up population-based cohort study comprising all COPD patients receiving LTOT in the canton of Bern, Switzerland. Comparing age- and sex-adjusted standardized mortality ratios, we examined associations between all-cause mortality and patient characteristics at baseline. To avoid immortal time bias, data for incident (receiving LTOT <6 months and prevalent users were analyzed separately. Results: At baseline, 475 patients (20% incident users, n=93 were receiving LTOT because of COPD (48/100,000 inhabitants. Mortality of incident and prevalent LTOT users was 41% versus 27%, respectively, p<0.007, and standardized mortality ratios were 8.02 (95% CI: 5.64–11.41 versus 5.90 (95% CI: 4.79–7.25, respectively. Type 2 respiratory failure was associated with higher standardized mortality ratios among incident LTOT users (60.57, 95% CI: 11.82–310.45, p=0

  3. Completely quantized collapse and consequences

    International Nuclear Information System (INIS)

    Pearle, Philip

    2005-01-01

    Promotion of quantum theory from a theory of measurement to a theory of reality requires an unambiguous specification of the ensemble of realizable states (and each state's probability of realization). Although not yet achieved within the framework of standard quantum theory, it has been achieved within the framework of the continuous spontaneous localization (CSL) wave-function collapse model. In CSL, a classical random field w(x,t) interacts with quantum particles. The state vector corresponding to each w(x,t) is a realizable state. In this paper, I consider a previously presented model, which is predictively equivalent to CSL. In this completely quantized collapse (CQC) model, the classical random field is quantized. It is represented by the operator W(x,t) which satisfies [W(x,t),W(x ' ,t ' )]=0. The ensemble of realizable states is described by a single state vector, the 'ensemble vector'. Each superposed state which comprises the ensemble vector at time t is the direct product of an eigenstate of W(x,t ' ), for all x and for 0≤t ' ≤t, and the CSL state corresponding to that eigenvalue. These states never interfere (they satisfy a superselection rule at any time), they only branch, so the ensemble vector may be considered to be, as Schroedinger put it, a 'catalog' of the realizable states. In this context, many different interpretations (e.g., many worlds, environmental decoherence, consistent histories, modal interpretation) may be satisfactorily applied. Using this description, a long-standing problem is resolved, where the energy comes from the particles gain due to the narrowing of their wave packets by the collapse mechanism. It is shown how to define the energy of the random field and its energy of interaction with particles so that total energy is conserved for the ensemble of realizable states. As a by-product, since the random-field energy spectrum is unbounded, its canonical conjugate, a self-adjoint time operator, can be discussed. Finally, CSL

  4. Magnesium/calcium related neurological disorders in the ALS focus of the Kii Peninsula

    International Nuclear Information System (INIS)

    Yasui, Masayuki; Yoshida, Munehito; Tamaki, Tetsuya; Taniguchi, Yasunori; Minamide, Akihito; Ota, Kiichiro; Sasajima, Kazuhisa.

    1997-01-01

    Current epidemiological surveys in the Western Pacific area and Kii Peninsula have suggested that low calcium(Ca), magnesium(Mg) and high aluminum(Al) and manganese(Mn) in river, soil and drinking water may be implicated in the pathogenetic process of amyotrophic lateral sclerosis(ALS) and Parkinsonism-dementia(PD). The condition of unbalanced minerals was experimentally mimicked in this study using rats. Male Wistar rats, weighing 200 g, were maintained for 90 days on the following diets: (A) standard diet, (B) low Ca diet, (C) low Ca-Mg diet, (D) low Ca-Mg diet with high Al. In the groups maintained on unbalanced mineral diets, Ca and Mg contents of the bones were lower than standard diet. On the other hand, Ca content of CNS showed higher values in the unbalanced diet groups than those in the standard diet group. This was determined by neutron activation analysis(NAA) at KUR. Also, Ca content in soft tissues of rats given unbalanced mineral diets was higher than those on standard diet. Mg content of soft tissues and spinal cord of rats was markedly lower in the low Ca-Mg plus high Al diet group than the other three groups as determined by inductively coupled plasma emission spectrometry(ICP). Six Kii cases with amyotrophic lateral sclerosis(ALS) also showed higher Ca and lower Mg contents in the CNS tissues than those of neurologically normal controls. The calcification of the spinal ligaments(CSL) has been reported in only 120 cases in the world and 28 cases of CSL in the Kii Peninsula have been found in the same foci as ALS. We analyzed Mg content of 7 spinal bones and 10 ligaments of the CSL and Ca content of 5 spinal bones compared with controls. The CSL showed lower values of Mg contents in bones and ligaments compared to controls. The Ca content in bones of CSL was significantly lower than that of controls. This suggests that the environmental factor may contribute to the pathogenesis of CSL due to low Ca and Mg intake as well as for ALS. (J.P.N.)

  5. Errata Resonance, Vol.20, No.12, 2015. Rajaram Nityananda, Sun ...

    Indian Academy of Sciences (India)

    IAS Admin

    Resonance, Vol.20, No.12, 2015. Rajaram Nityananda, Sun, Sky and Clouds: Where Light and Matter Meet. Page 1121: The correct Figure 5 is reproduced below: Resonance, Vol.20, No.11, 2015. Anil Kumar, Felix Bloch (1905–1983). Page 956: Para 1, Line 5, 'also from Zürich' should be read as 'from nearby Bern'.

  6. What's Slithering around on Your School Grounds? Transforming Student Awareness of Reptile & Amphibian Diversity

    Science.gov (United States)

    Tomasek, Terry M.; Matthews, Catherine E.; Hall, Jeff

    2005-01-01

    The protocols used in a research project on amphibian and reptile diversity at Cool Springs Environmental Education Center near New Bern, North Carolina is described. An increasing or stable number of amphibians and reptiles would indicate that the forest has a balance of invertebrates, leaf litter, moisture, pH, debris, burrows and habitat…

  7. 75 FR 18074 - Changes in Flood Elevation Determinations

    Science.gov (United States)

    2010-04-09

    ...). Marietta Daily County Board of Journal. Commissioners, 100 Cherokee Street, Marietta, GA 30090. Illinois...). Sun Journal. 406 Craven Street, New Bern, NC 28560. Durham City of Durham (08-04- August 27, 2009; The..., 1001 Preston Street, Suite 911, Houston, TX 77002. Travis City of Austin (09-06- October 12, 2009; The...

  8. Bam Earthquake in Iran

    CERN Multimedia

    2004-01-01

    Following their request for help from members of international organisations, the permanent Mission of the Islamic Republic of Iran has given the following bank account number, where you can donate money to help the victims of the Bam earthquake. Re: Bam earthquake 235 - UBS 311264.35L Bubenberg Platz 3001 BERN

  9. Competition between Public Supervision and Professional Management: An Ethnographic Study of School Governance Reforms in Switzerland

    Science.gov (United States)

    Hangartner, Judith; Svaton, Carla Jana

    2014-01-01

    This article discusses insights from an ethnographic study of local governance practices in the Canton of Bern, Switzerland, under changing policy conditions. Recent reforms introduced and strengthened the position of head teachers, enhanced the responsibility of the municipalities and introduced new quality management procedures in local…

  10. Compacting coastal plain soils changes midrotation loblolly pine allometry by reducing root biomass

    Science.gov (United States)

    Kim H. Ludovici

    2008-01-01

    Factorial combinations of soil compaction and organic matter removal were replicated at the Long Term Site Productivity study in the Croatan National Forest, near New Bern, North Carolina, USA. Ten years after planting, 18 preselected loblolly pine (Pinus taeda L.) trees were destructively harvested to quantify treatment effects on total above- and...

  11. Perché è necessario capire il web

    CERN Multimedia

    Rosenthal, Edward C

    2007-01-01

    The birth of the cobweb of contents, the web 2.0, Wikipedia, the global collaboration, i blog, the net neutrality, the digital liberty and the future of the net: interview with Robert Cailliau, inventor of the WWW with Tim Bernes-Lee. (2 pages)

  12. From Autonomy to Quality Management: NPM Impacts on School Governance in Switzerland

    Science.gov (United States)

    Hangartner, Judith; Svaton, Carla Jana

    2013-01-01

    This article reviews the impact of discourses on "New Public Management" (NPM) on compulsory schooling in Switzerland during the last two decades and traces its implementation in the Canton of Bern. The analysis suggests that while NPM reformers initially promoted increased school autonomy, the introduction of market elements and school…

  13. Diccionario de lingüística

    Directory of Open Access Journals (Sweden)

    Eduardo Miranda Nelson

    Full Text Available THEODOR LEWANDOWSKI, DICCIONARIO DE LINGUISTICA, Madrid, Ediciones Cátedra, S.A., 1982, XIV, 447 págs. Traducción del alemán por María Luz García-Denche y Enrique Bernárdez.

  14. Strategic Reading Groups: Guiding Readers in the Middle Grades

    Science.gov (United States)

    Berne, Jennifer; Degener, Sophie C.

    2012-01-01

    Strategic grouping can transform reading instruction in the middle grades from a hit-or-miss learning experience to a targeted, responsive one. This book features a practical and field-tested model for small-group differentiated reading instruction in Grades 4-8. Jennifer Berne and Sophie C. Degener offer a clear, detailed discussion of how to…

  15. [Olaf Asendorf. Das Veto des Deutschen Ordens gegen die Erhöhung des Nikolaikirchturmes in Reval] / Paul Kaegbein

    Index Scriptorium Estoniae

    Kaegbein, Paul

    2006-01-01

    Arvustus: Olaf Asendorf. Das Veto des Deutschen Ordens gegen die Erhöhung des Nikolaikirchturmes in Reval. In: Asendorf: Mittelalterliche Türme im deutschordensland Preussen. Frankfurt am Main, Berlin, Bern, New York, Paris, Wien: Lang 1998. S. 105-109. Niguliste kiriku torni ehitusloost

  16. Library science talks : eleventh season 2005

    CERN Multimedia

    2005-01-01

    The Swiss National Library in Berne, the Association of International Librarians and Information Specialists AILIS and the CERN Scientific Information Service are pleased to announce their 2005 series of Library Science Talks. The series offers library and archive staff the possibility of learning from and communicating with personalities in library services and organizations. The talks cover important and topical issues for librarians.

  17. Tõlkeloo arvukad dimensioonid / Hannu K. Riikonen

    Index Scriptorium Estoniae

    Riikonen, Hannu K.

    2012-01-01

    Arvustus: Antonie Chalvin, Anne Lange, Daniele Monticelli (Eds.) Between cultures and texts : itineraries in translation history = Entre les cultures et les textes : itinéraires en histoire de la traduction. Frankfurt am Main-Berlin-Bern-Bruxelles-New York-Oxford-Wien 2011

  18. Nieuwe vondsten van zeldzame planten in 1999 en 2000

    NARCIS (Netherlands)

    Meijden, van der Ruud; Holverda, Wout J.; Slikke, van der Wout J.

    2001-01-01

    The best news is the discovery of a new inland locality of Apium repens, an endangered species included in both the Habitat Directive and the Berne Convention. The List has a striking number of new records of rare ferns: Asplenium adiantum-nigrum, A. septentrionalis, Botrychium lunaria, Ceterach

  19. Academic Training: Climate change and challenges for the environment / POSTPONED!!!

    CERN Multimedia

    Françoise Benz

    2005-01-01

    2004-2005 ACADEMIC TRAINING PROGRAMME LECTURE SERIES 20, 21, 22 June 20, 21, 22 June, from 11:00 to 12:00 – Main Auditorium, bldg. 500 Climate change and challenges for the environment C. SCHLUECHTER / Univ. Bern, CH The Academic Training is postponed.

  20. Lexicography, Terminography and Copyright

    African Journals Online (AJOL)

    stern from the very nature of a dictionary as a specific kind of intellectual pro- perty type, because of ... --The most important convention that binds us today, is still the Berne Con- ention, as ..... These units or data element categories are described ... terminologist to use these terms as well as their definitions to a large extent.

  1. Drama in Life: The Uses of Communication in Society.

    Science.gov (United States)

    Combs, James E.; Mansfield, Michael W.

    Bringing together 35 of the most notable contributions of authors such as Kenneth Burke, Erving Goffman, and Eric Berne, this book provides an introduction to the dramaturgical perspective of social actions. Selections stem from the conception that many "real-life" actions and events can most adequately be understood in terms of drama. Included…

  2. 100eme anniversaire de la théorie de la relativité Une BD romande : Mélanges Einstein (Albert) et l'histoire de la physique

    CERN Multimedia

    Tesnier, Grégory

    2005-01-01

    2005 has been delcared "Year of Physics" by UNESCO and ONU to celebrate the 100th anniversary of the theory of relativity, elaborated by Einstein (who lived in Bern). To hon. Einstein, an historical comic strip has been published (1 page)

  3. Badger hair in shaving brushes comes from protected Eurasian badgers

    NARCIS (Netherlands)

    Domingo-Roura, X.; Marmi, J.; Ferrando, A.; López-Giráldez, F.; Macdonald, D.W.; Jansman, H.A.H.

    2006-01-01

    The Eurasian badger (Meles meles) is included in Appendix III of the Bern Convention and protected by national laws in many European countries. Badger hair is used to manufacture luxury shaving brushes, although it is frequently argued that the hog badger (Arctonyx collaris), which in Europe is an

  4. Research Paper ISSN: 2006-0165©2009

    African Journals Online (AJOL)

    AJTCAM

    Personal hygiene and basic sanitation can cut this toll dramatically. A significant number of illnesses and deaths are reported annually as a result of unsanitary conditions. Diarrhoea-related illnesses alone are estimated to cause two to three million deaths per year; a majority of the mortality occurs in children (Bern et al., ...

  5. Latitudinal variation in the occurrence of GPS L-band scintillations ...

    Indian Academy of Sciences (India)

    TEC (ROT) and the rate of change of TEC index. (ROTI) have been studied by several researchers to ... is also of interest to study the spatial and tempo- ral variabilities of the GPS L-band scintillations in ...... tional GPS Service for Geodynamics, Berne, Switzerland,. March 25–26, 351p. Weber E J, Basu S, Bullett T W, ...

  6. Untitled

    African Journals Online (AJOL)

    Evaluation of nutrition education in third world communities: A. Nestlé Foundation workshop. Lutry/Lausanne Hans Huber pub. Bern. Sturtgart Vienne. pp 17-27. Jones, D.Y., Meshiem, M.C. and Habitch, J.P.. (1985). Influences of child growth associated with poverty: Cross-section. United States National surveys. Am. J. Clin.

  7. Anti-hepatocarcinoma effects of berberine nanosuspension against human HepG2 and Huh7 cells as well as H22 tumor bearing mice

    Science.gov (United States)

    Wang, Zhi-ping; Wu, Jun-biao; Zhou, Qun; Wang, Yi-fei; Chen, Tongsheng

    2014-09-01

    Hepatocarcinoma, a malignant cancer, threaten human life badly. It is a current issue to seek the effective natural remedy from plant to treat cancer due to the resistance of the advanced hepatocarcinoma to chemotherapy. Berberine (Ber), an isoquinoline derivative alkaloid, has a wide range of pharmacological properties and is considered to have anti-hepatocarcinoma effects. However its low oral bioavailability restricts its wide application. In this report, Ber nanosuspension (Ber-NS) composed of Ber and D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) was prepared by high pressure homogenization technique. Both in vitro and in vivo anti-hepatocarcinoma effects of Ber-NS relative to effcacy of bulk Ber were evaluated. The particle size and zeta potential of Ber-NS were 73.1 +/- 3.7 nm and 6.99 +/- 0.17 mV, respectively. Ber-NS exhibited significant inhibitory effects against human HepG2 and Huh7 cells, and the corresponding IC50 values were 8.1 and 4.7 μg/ml (18.3 and 6.5 μg/ml of Ber solution). In vivo studies also showed higher antitumor efficacy, and inhibition rates was 63.7% (41.4 % of Ber solution) at 100 mg/kg intragastric administration in the H22 solid tumor bearing mice. These results suggest that the delivery of Ber as a nanosuspension is a promising approach for treating hepatocarcinoma.

  8. How Einstein Discovered "E[subscript 0] = mc[squared]"

    Science.gov (United States)

    Hecht, Eugene

    2012-01-01

    This paper traces Einstein's discovery of "the equivalence of mass [m] and energy ["E[subscript 0]"]." He came to that splendid insight in 1905 while employed by the Bern Patent Office, at which time he was not an especially ardent reader of physics journals. How then did the young savant, working outside of academia in semi-isolation, realize…

  9. Client and event driven data hub system at CDF

    International Nuclear Information System (INIS)

    Kilminster, Ben; McFarland, Kevin; Vaiciulis, Tony; Matsunaga, Hiroyuki; Shimojima, Makoto

    2001-01-01

    The Consumer-Server Logger (CSL) system at the Collider Detector at Fermilab is a client and event driven data hub capable of receiving physics events from multiple connections, and logging them to multiple streams while distributing them to multiple online analysis programs (consumers). Its multiple-partitioned design allows data flowing through different paths of the detector sub-systems to be processed separately. The CSL system, using a set of internal memory buffers and message queues mapped to the location of events within its programs, and running on an SGI 2200 Server, is able to process at least the required 20 MB/s of constant event logging (75 Hz of 250 KB events) while also filtering up to 10 MB/s to consumers requesting specific types of events

  10. Chiral spin liquids at finite temperature in a three-dimensional Kitaev model

    Science.gov (United States)

    Kato, Yasuyuki; Kamiya, Yoshitomo; Nasu, Joji; Motome, Yukitoshi

    2017-11-01

    Chiral spin liquids (CSLs) in three dimensions and thermal phase transitions to paramagnet are studied by unbiased Monte Carlo simulations. For an extension of the Kitaev model to a three-dimensional tricoordinate network dubbed the hypernonagon lattice, we derive low-energy effective models in two different anisotropic limits. We show that the effective interactions between the emergent Z2 degrees of freedom called fluxes are unfrustrated in one limit, while highly frustrated in the other. In both cases, we find a first-order phase transition to the CSL, where both time-reversal and parity symmetries are spontaneously broken. In the frustrated case, however, the CSL state is highly exotic—the flux configuration is subextensively degenerate while showing a directional order with broken C3 rotational symmetry. Our results provide two contrasting archetypes of CSLs in three dimensions, both of which allow approximation-free simulation for investigating the thermodynamics.

  11. Genetics and physiology of cell wall polysaccharides in the model C4 grass, Setaria viridis spp.

    Science.gov (United States)

    Ermawar, Riksfardini A; Collins, Helen M; Byrt, Caitlin S; Henderson, Marilyn; O'Donovan, Lisa A; Shirley, Neil J; Schwerdt, Julian G; Lahnstein, Jelle; Fincher, Geoffrey B; Burton, Rachel A

    2015-10-02

    Setaria viridis has emerged as a model species for the larger C4 grasses. Here the cellulose synthase (CesA) superfamily has been defined, with an emphasis on the amounts and distribution of (1,3;1,4)-β-glucan, a cell wall polysaccharide that is characteristic of the grasses and is of considerable value for human health. Orthologous relationship of the CesA and Poales-specific cellulose synthase-like (Csl) genes among Setaria italica (Si), Sorghum bicolor (Sb), Oryza sativa (Os), Brachypodium distachyon (Bradi) and Hordeum vulgare (Hv) were compared using bioinformatics analysis. Transcription profiling of Csl gene families, which are involved in (1,3;1,4)-β-glucan synthesis, was performed using real-time quantitative PCR (Q-PCR). The amount of (1,3;1,4)-β-glucan was measured using a modified Megazyme assay. The fine structures of the (1,3;1,4)-β-glucan, as denoted by the ratio of cellotriosyl to cellotetraosyl residues (DP3:DP4 ratio) was assessed by chromatography (HPLC and HPAEC-PAD). The distribution and deposition of the MLG was examined using the specific antibody BG-1 and captured using fluorescence and transmission electron microscopy (TEM). The cellulose synthase gene superfamily contains 13 CesA and 35 Csl genes in Setaria. Transcript profiling of CslF, CslH and CslJ gene families across a vegetative tissue series indicated that SvCslF6 transcripts were the most abundant relative to all other Csl transcripts. The amounts of (1,3;1,4)-β-glucan in Setaria vegetative tissues ranged from 0.2% to 2.9% w/w with much smaller amounts in developing grain (0.003% to 0.013% w/w). In general, the amount of (1,3;1,4)-β-glucan was greater in younger than in older tissues. The DP3:DP4 ratios varied between tissue types and across developmental stages, and ranged from 2.4 to 3.0:1. The DP3:DP4 ratios in developing grain ranged from 2.5 to 2.8:1. Micrographs revealing the distribution of (1,3;1,4)-β-glucan in walls of different cell types and the data were

  12. Grain-boundary engineering applied to grain growth in a high temperature material

    International Nuclear Information System (INIS)

    Huda, Z.

    1993-01-01

    Crystallography of grain boundaries are determined for a high temperature material, before and after grain growth processes, so as to study the induction of special properties useful for application in components of a gas-turbine engine. The philosophy of grain-boundary engineering is applied to grain growth in APK-6, a powder formed nickel-base superalloy so as to establish the possible structure/property relationships. The alloy in the as received condition is shown to possess a strong texture and contained coincident site lattices (CSL) boundaries with most boundaries having sigma values in the range of 3 > sigma > 25. A normal grain-growth heat treatment result in a good population of low angle grain boundaries, and drastically reduces the proportion of CSL boundaries. A strong [011] annealing texture is observed after an intermediate grain growth; most grain boundaries, here, tend to be high angle indicating a possibility of possessing special properties. (author)

  13. Detoxification of furfural residues hydrolysate for butanol fermentation by Clostridium saccharobutylicum DSM 13864.

    Science.gov (United States)

    Dong, Jin-Jun; Han, Rui-Zhi; Xu, Guo-Chao; Gong, Lei; Xing, Wan-Ru; Ni, Ye

    2018-07-01

    The toxicity of furfural residues (FRs) hydrolysate is a major obstacle in its application. This work focused on the detoxification of FRs hydrolysate and its application in butanol fermentation. Combination of activated carbon and resin 717 was appropriate for the detoxification of hydrolysate. Mixed sterilization of FRs hydrolysate and corn steep liquor (CSL) was better than the separate ones, since proteins in CSL could adsorb and remove toxic components during sterilization. The results further confirmed that simultaneous sterilization of activated carbon + resin and fermentation medium was more efficient for detoxification and butanol production, in which 76.4% of phenolic compounds and 99.3% of Maillard reaction products were removed, 8.48 g/L butanol and 12.61 g/L total solvent were obtained. This study provides feasible and economic approaches for the detoxification of FRs hydrolysate and its application in butanol production. Copyright © 2018 Elsevier Ltd. All rights reserved.

  14. Crystal structure of caesium hydrogen (L)-aspartate and an overview of crystalline compounds of aspartic acid with inorganic constituents

    Energy Technology Data Exchange (ETDEWEB)

    Fleck, M. [Universitaet Wien (Austria). Institut fuer Mineralogie und Kristallographie; Emmerich, R.; Bohaty, L. [Universitaet zu Koeln (Austria). Institut fuer Kristallographie

    2010-08-15

    The crystal structure of the new polar compound caesium hydrogen (L)-aspartate, Cs(C{sub 4}H{sub 6}NO{sub 4}), (abbreviated: Cs(L -AspH)) was determined from single crystal X-ray diffraction data; it comprises two crystallographically different L -AspH anions that are connected via caesium cations to form a three dimensional framework. The Cs ions are irregularly sevenfold[Cs1O{sub 7}] respectively eightfold[Cs2O{sub 8}] coordinated to all {alpha}- and {beta}- carboxylate oxygen atoms. Cs(L -AspH) represents a novel structure type of its own, as do most compounds of (L)-aspartic acid with inorganic constituents. A brief summary of such structurally known aspartates is given. (copyright 2010 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  15. Improved Noninterferometric Test of Collapse Models Using Ultracold Cantilevers

    Science.gov (United States)

    Vinante, A.; Mezzena, R.; Falferi, P.; Carlesso, M.; Bassi, A.

    2017-09-01

    Spontaneous collapse models predict that a weak force noise acts on any mechanical system, as a consequence of the collapse of the wave function. Significant upper limits on the collapse rate have been recently inferred from precision mechanical experiments, such as ultracold cantilevers and the space mission LISA Pathfinder. Here, we report new results from an experiment based on a high-Q cantilever cooled to millikelvin temperatures, which is potentially able to improve the current bounds on the continuous spontaneous localization (CSL) model by 1 order of magnitude. High accuracy measurements of the cantilever thermal fluctuations reveal a nonthermal force noise of unknown origin. This excess noise is compatible with the CSL heating predicted by Adler. Several physical mechanisms able to explain the observed noise have been ruled out.

  16. Improved memory characteristics by NH3-nitrided GdO as charge storage layer for nonvolatile memory applications

    International Nuclear Information System (INIS)

    Liu, L.; Xu, J. P.; Ji, F.; Chen, J. X.; Lai, P. T.

    2012-01-01

    Charge-trapping memory capacitor with nitrided gadolinium oxide (GdO) as charge storage layer (CSL) is fabricated, and the influence of post-deposition annealing in NH 3 on its memory characteristics is investigated. Transmission electron microscopy, x-ray photoelectron spectroscopy, and x-ray diffraction are used to analyze the cross-section and interface quality, composition, and crystallinity of the stack gate dielectric, respectively. It is found that nitrogen incorporation can improve the memory window and achieve a good trade-off among the memory properties due to NH 3 -annealing-induced reasonable distribution profile of a large quantity of deep-level bulk traps created in the nitrided GdO film and reduction of shallow traps near the CSL/SiO 2 interface.

  17. Studies on the antimicrobial effect of corn steep liquor on some ...

    African Journals Online (AJOL)

    Using well diffusion method, 0.1 ml (100 μl) of the liquor effectively inhibited the growth of the test organisms with zones of inhibition ranging from 4.00 ± 0.28 to 20.20 ± 0.14 mm. The zones of inhibition increased with increasing number of days of fermentation of the filtrate on which is the CSL. However, there was no ...

  18. Method for hull-less barley transformation and manipulation of grain mixed-linkage beta-glucan.

    Science.gov (United States)

    Lim, Wai Li; Collins, Helen M; Singh, Rohan R; Kibble, Natalie A J; Yap, Kuok; Taylor, Jillian; Fincher, Geoffrey B; Burton, Rachel A

    2018-05-01

    Hull-less barley is increasingly offering scope for breeding grains with improved characteristics for human nutrition; however, recalcitrance of hull-less cultivars to transformation has limited the use of these varieties. To overcome this limitation, we sought to develop an effective transformation system for hull-less barley using the cultivar Torrens. Torrens yielded a transformation efficiency of 1.8%, using a modified Agrobacterium transformation method. This method was used to over-express genes encoding synthases for the important dietary fiber component, (1,3;1,4)-β-glucan (mixed-linkage glucan), primarily present in starchy endosperm cell walls. Over-expression of the HvCslF6 gene, driven by an endosperm-specific promoter, produced lines where mixed-linkage glucan content increased on average by 45%, peaking at 70% in some lines, with smaller increases in transgenic HvCslH1 grain. Transgenic HvCslF6 lines displayed alterations where grain had a darker color, were more easily crushed than wild type and were smaller. This was associated with an enlarged cavity in the central endosperm and changes in cell morphology, including aleurone and sub-aleurone cells. This work provides proof-of-concept evidence that mixed-linkage glucan content in hull-less barley grain can be increased by over-expression of the HvCslF6 gene, but also indicates that hull-less cultivars may be more sensitive to attempts to modify cell wall composition. © 2017 Institute of Botany, Chinese Academy of Sciences.

  19. Nursing students' perceptions of factors influencing their learning environment in a clinical skills laboratory: A qualitative study.

    Science.gov (United States)

    Haraldseid, Cecilie; Friberg, Febe; Aase, Karina

    2015-09-01

    The mastery of clinical skills learning is required to become a trained nurse. Due to limited opportunities for clinical skills training in clinical practice, undergraduate training at clinical skills laboratories (CSLs) is an essential part of nursing education. In a sociocultural learning perspective learning is situated in an environment. Growing student cohorts, rapid introduction of technology-based teaching methods and a shift from a teaching- to a learning-centered education all influence the environment of the students. These changes also affect CSLs and therefore compel nursing faculties to adapt to the changing learning environment. This study aimed to explore students' perceptions of their learning environment in a clinical skills laboratory, and to increase the knowledge base for improving CSL learning conditions identifying the most important environmental factors according to the students. An exploratory qualitative methodology was used. Nineteen second-year students enrolled in an undergraduate nursing program in Norway participated in the study. They took the same clinical skills course. Eight were part-time students (group A) and 11 were full-time students (group B). Focus group interviews and content analysis were conducted to capture the students' perception of the CSL learning environment. The study documents students' experience of the physical (facilities, material equipment, learning tools, standard procedures), psychosocial (expectations, feedback, relations) and organizational (faculty resources, course structure) factors that affect the CSL learning environment. Creating an authentic environment, facilitating motivation, and providing resources for multiple methods and repetitions within clinical skills training are all important for improving CSL learning environments from the student perspective. Copyright © 2015 Elsevier Ltd. All rights reserved.

  20. Possible origin of superior corrosion resistance for electrodeposited nanocrystalline Ni

    International Nuclear Information System (INIS)

    Roy, I.; Yang, H.W.; Dinh, L.; Lund, I.; Earthman, J.C.; Mohamed, F.A.

    2008-01-01

    We present here for the first time observations that grain boundaries in electrodeposited (ED) nanocrystalline (nc) Ni are predominantly of Σ3 character. The results presented are based on orientation imaging microscopy (OIM) performed to produce electron backscatter diffraction (EBSD) maps. This large volume fraction of coherent low sigma coincidence site lattice (CSL) boundaries appears to be consistent with the superior corrosion resistance of ED nc-Ni in comparison with its coarse-grained counterpart

  1. The Hybrid Threat: Crime, Terrorism and Insurgency in Mexico. Proceedings of the Joint Policy and Research Forum

    Science.gov (United States)

    2011-12-01

    to name a few. Drug trafficking in Mexico is big, if illicit, business. The most notorious players include the Sinaloa Cartel, the Gulf Cartel...091311.pdf. A Joint CSL-HSPI Study12 problem didn’t originate in Mexico, but migrated there in force after Colombia cracked down on its own drug lords...four’ – Jua´rez, Gulf, Sinaloa , and Tijuana – which operate generally in the north. But, perhaps foreshadowing a fourth generation in the gangs

  2. Lysine and Glutamic Acids as the End Products of Multi-response of Optimized Fermented Medium by Mucor mucedo KP736529.

    Science.gov (United States)

    El-Hersh, Mohammed S; Saber, WesamEldin I A; El-Fadaly, Husain A; Mahmoud, Mohammed K

    Amino acids are important for living organisms, they acting as crucial for metabolic activities and energy generation, wherein the deficiency in these amino acids cause various physiological defects. The aim of this study is to investigate the effect of some nutritional factors on the amino acids production by Mucor mucedo KP736529 during fermentation intervals. Mucor mucedo KP736529 was selected according to proteolytic activity. Corn steep liquor and olive cake were used in the fermented medium during Placket-Burman and central composite design to maximize the production of lysine and glutamic acids. During the screening by Plackett-Burman design, olive cake and Corn Steep Liquor (CSL) had potential importance for the higher production of amino acids. The individual fractionation of total amino acids showed both lysine and glutamic as the major amino acids associated with the fermentation process. Moreover, the Central Composite Design (CCD) has been adopted to explain the interaction between olive cake and CSL on the production of lysine and glutamic acids. The model recorded significant F-value, with high values of R 2, adjusted R 2 and predicted R 2 for both lysine and glutamic, indicating the validity of the data. Solving equation for maximum production of lysine recorded theoretical levels of olive cake and CSL, being 2.58 and 1.83 g L -1, respectively, with predicting value of lysine at 1.470 μg mL -1, whereas the predicting value of glutamic acid reached 0.805 mg mL -1 at levels of 2.49 and 1.93 g L -1 from olive cake and CSL, respectively. The desirability function (D) showed the actual responses being 1.473±0.009 and 0.801±0.004 μg mL -1 for lysine and glutamic acids, respectively. The model showed adequate validity to be applied in a large-scale production of both lysine and glutamic acids.

  3. Adhesion of periodontal pathogens to self-ligating orthodontic brackets: An in-vivo prospective study.

    Science.gov (United States)

    Jung, Woo-Sun; Kim, Kyungsun; Cho, Soha; Ahn, Sug-Joon

    2016-09-01

    Our aims were to analyze adhesion of periodontopathogens to self-ligating brackets (Clarity-SL [CSL], Clippy-C [CC] and Damon Q [DQ]) and to identify the relationships between bacterial adhesion and oral hygiene indexes. Central incisor brackets from the maxilla and mandible were collected from 60 patients at debonding after the plaque and gingival indexes were measured. Adhesions of Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), Prevotella intermedia (Pi), Fusobacterium nucleatum (Fn), and Tannerella forsythia (Tf) were quantitatively determined using real-time polymerase chain reactions. Factorial analysis of variance was used to analyze bacterial adhesion in relation to bracket type and jaw position. Correlation coefficients were calculated to determine the relationships between bacterial adhesion and the oral hygiene indexes. Total bacteria showed greater adhesion to CSL than to DQ brackets, whereas Aa, Pg, and Pi adhered more to DQ than to CSL brackets. CC brackets showed an intermediate adhesion pattern between CSL and DQ brackets, but it did not differ significantly from either bracket type. Adhesion of Fn and Tf did not differ significantly among the 3 brackets. Most bacteria were detected in greater quantities in the mandibular than in the maxillary brackets. The plaque and gingival indexes were not strongly correlated with bacterial adhesion to the brackets. Because Aa, Pg, and Pi adhered more to the DQ brackets in the mandibular area, orthodontic patients with periodontal problems should be carefully monitored in the mandibular incisors where the distance between the bracket and the gingiva is small, especially when DQ brackets are used. Copyright © 2016 American Association of Orthodontists. Published by Elsevier Inc. All rights reserved.

  4. Optimization of polyhydroxybutyrate production by Bacillus sp. CFR 256 with corn steep liquor as a nitrogen source

    OpenAIRE

    Vijayendra, S. V. N.; Rastogi, N. K.; Shamala, T. R.; Anil Kumar, P. K.; Kshama, L.; Joshi, G. J.

    2007-01-01

    Polyhydroxyalkanotes (PHAs), the eco-friendly biopolymers produced by many bacteria, are gaining importance in curtailing the environmental pollution by replacing the non-biodegradable plastics derived from petroleum. The present study was carried out to economize the polyhydroxybutyrate (PHB) production by optimizing the fermentation medium using corn steep liquor (CSL), a by-product of starch processing industry, as a cheap nitrogen source, by Bacillus sp. CFR 256. Response surface methodol...

  5. Thirdyear medical students’ and clinical teachers’ perceptions of formative assessment feedback in the simulated clinical setting

    Directory of Open Access Journals (Sweden)

    Reina Abraham

    2016-05-01

    Full Text Available Background. Clinical skills training in the clinical skills laboratory (CSL environment forms an important part of the undergraduate medical curriculum. These skills are better demonstrated than described. A lack of direct observation and feedback given to medical students performing these skills has been reported. Without feedback, errors are uncorrected, good performance is not reinforced and clinical competence is minimally achieved. Objectives. To explore the perceptions of 3rd-year medical students and their clinical teachers about formative clinical assessment feedback in the CSL setting. Methods. Questionnaires with open- and closed-ended questions were administered to 3rd-year medical students and their clinical skills teachers. Quantitative data were statistically analysed while qualitative data were thematically analysed. Results. Five clinical teachers and 183 medical students participated. Average scores for the items varied between 1.87 and 5.00 (1: negative to 5:positive. The majority of students reported that feedback informed them of their competence level and learning needs, and motivated them to improve their skills and participation in patient-centred learning activities. Teachers believed that they provided sufficient and balanced feedback. Some students were concerned about the lack of standardised and structured assessment criteria and variation in teacher feedback. No statistical difference (p<0.05 was found between the mean item ratings based on demographic and academic background. Conclusion. Most teachers and students were satisfied with the feedback given and received, respectively. Structured and balanced criterion-referenced feedback processes, together with feedback training workshops for staff and students, are recommended to enhance feedback practice quality in the CSL. Limited clinical staff in the CSL was noted as a concern.

  6. Implementing peer tutoring in a graduate medical education programme.

    Science.gov (United States)

    Salerno-Kennedy, Rossana; Henn, Pat; O'Flynn, Siun

    2010-06-01

    In modern times, peer tutoring methods have been explored in health care education for over 30 years. In this paper, we report our experience of implementing a peer-tutoring approach to Clinical Skills Laboratory (CSL) training in the Graduate Entry in Medicine Programme (GEM) at University College Cork. Eighteen fourth-year medical students were recruited as peer tutors for CSL sessions on physical examination. In order to standardise the process, we developed a training course for peer tutors that comprised two stages. They then ran the practical sessions with junior students, under the watchful eye of medical educators. At the end of the last CSL session, the students were given 10 minutes to reflect individually on the experience, and were asked to complete a feedback form. Twenty-four of the 42 GEM students and six of the seven Senior Tutors (STs) completed and returned their feedback forms. With the caveats of small sample sizes and low response rates, both groups reported that they had both positive and negative experiences of peer tutoring, but that the positive experiences predominated. The overall experience was positive. In terms of the primary thesis of this study, the STs thought that they were well prepared by the teaching staff to take part in these teaching sessions. © Blackwell Publishing Ltd 2010.

  7. Evidence for an association between nonsyndromic cleft lip with or without cleft palate and a gene located on the long arm of chromosome 4

    Energy Technology Data Exchange (ETDEWEB)

    Mitchell, L.E.; Healey, S.C.; Chenevix-Trench, G. [St. Louis Univ. Health Sciences Center, MO (United States)]|[Queensland Institute of Medical Research, Brisbane (Australia)

    1995-11-01

    Recent studies suggest that the familial aggregation of nonsyndromic cleft lip with or without cleft palate (CL{+-}P) is likely to be attributable to the effects of several susceptibility loci, acting in a multiplicative fashion. Two potential CL{+-}P susceptibility loci (CSL), transforming growth factor alpha (TGFA) and retinoic acid receptor (RARA), have been identified through association studies. In addition, recent evidence of linkage between CL{+-}P and two markers (D4S175 and D4S192) in the region 4q25-4q31.3 raised the possibility that a CSL, with a larger effect than either TGFA or RARA, may reside within this region of the human genome. The present analyses were undertaken to determine whether D4S175 or D4S192 is significantly associated with CL{+-}P in a sample of unrelated patients that have previously provided evidence of associations between CL{+-}P and both TGFA and RARA. The results of these analyses provide further, tentative, evidence for the presence of a CSL locus on the long arm of chromosome 4 and help to refine the location of this locus in the region of D4S175 and D4S192. 28 refs., 4 tabs.

  8. Scalewise invariant analysis of the anisotropic Reynolds stress tensor for atmospheric surface layer and canopy sublayer turbulent flows

    Science.gov (United States)

    Brugger, Peter; Katul, Gabriel G.; De Roo, Frederik; Kröniger, Konstantin; Rotenberg, Eyal; Rohatyn, Shani; Mauder, Matthias

    2018-05-01

    Anisotropy in the turbulent stress tensor, which forms the basis of invariant analysis, is conducted using velocity time series measurements collected in the canopy sublayer (CSL) and the atmospheric surface layer (ASL). The goal is to assess how thermal stratification and surface roughness conditions simultaneously distort the scalewise relaxation towards isotropic state from large to small scales when referenced to homogeneous turbulence. To achieve this goal, conventional invariant analysis is extended to allow scalewise information about relaxation to isotropy in physical (instead of Fourier) space to be incorporated. The proposed analysis shows that the CSL is more isotropic than its ASL counterpart at large, intermediate, and small (or inertial) scales irrespective of the thermal stratification. Moreover, the small (or inertial) scale anisotropy is more prevalent in the ASL when compared to the CSL, a finding that cannot be fully explained by the intensity of the mean velocity gradient acting on all scales. Implications to the validity of scalewise Rotta and Lumley models for return to isotropy as well as advantages to using barycentric instead of anisotropy invariant maps for such scalewise analysis are discussed.

  9. Bounds on quantum collapse models from matter-wave interferometry: calculational details

    Science.gov (United States)

    Toroš, Marko; Bassi, Angelo

    2018-03-01

    We present a simple derivation of the interference pattern in matter-wave interferometry predicted by a class of quantum master equations. We apply the obtained formulae to the following collapse models: the Ghirardi-Rimini-Weber (GRW) model, the continuous spontaneous localization (CSL) model together with its dissipative (dCSL) and non-Markovian generalizations (cCSL), the quantum mechanics with universal position localization (QMUPL), and the Diósi-Penrose (DP) model. We discuss the separability of the dynamics of the collapse models along the three spatial directions, the validity of the paraxial approximation, and the amplification mechanism. We obtain analytical expressions both in the far field and near field limits. These results agree with those already derived in the Wigner function formalism. We compare the theoretical predictions with the experimental data from two recent matter-wave experiments: the 2012 far-field experiment of Juffmann T et al (2012 Nat. Nanotechnol. 7 297-300) and the 2013 Kapitza-Dirac-Talbot-Lau (KDTL) near-field experiment of Eibenberger et al (2013 Phys. Chem. Chem. Phys. 15 14696-700). We show the region of the parameter space for each collapse model that is excluded by these experiments. We show that matter-wave experiments provide model-insensitive bounds that are valid for a wide family of dissipative and non-Markovian generalizations.

  10. Immunostimulatory and anti-metastatic activity of polysaccharides isolated from byproducts of the corn starch industry.

    Science.gov (United States)

    Lee, Sue Jung; Lee, Ho Sung; Kim, Sun Young; Shin, Kwang-Soon

    2018-02-01

    Corn steep liquor (CSL) is a major by-product of the corn steeping process that is utilized in the wet milling industry. To develop new physiologically active polysaccharides from CSL, polysaccharides were isolated and their innate immunostimulatory and anti-metastatic activities were investigated. Corn byproduct polysaccharides (CBP) were preferentially isolated from CSL and further separated into supernatant (CBP1S) and precipitate (CBP1P) fractions. The anti-complementary activity of CBP1S was more potent than CBP1P and CBP. In addition, CBP1S enhanced production of macrophage-stimulating cytokines (e.g., IL-6 and IL-12) and natural killer (NK) cell-activating substances (e.g., granzyme and interferon-γ). Further, CBP1S significantly inhibited lung metastasis at a dose of 1000μg per mouse in an experimental lung metastasis model. These results suggest that CBP1S seems to promote the inhibition of lung metastasis through a mechanism leading to stimulation of the innate immune system, and CBP1S could be used as immunostimulating agents and for industrial applications. Copyright © 2017 Elsevier Ltd. All rights reserved.

  11. Real-time, resource-constrained object classification on a micro-air vehicle

    Science.gov (United States)

    Buck, Louis; Ray, Laura

    2013-12-01

    A real-time embedded object classification algorithm is developed through the novel combination of binary feature descriptors, a bag-of-visual-words object model and the cortico-striatal loop (CSL) learning algorithm. The BRIEF, ORB and FREAK binary descriptors are tested and compared to SIFT descriptors with regard to their respective classification accuracies, execution times, and memory requirements when used with CSL on a 12.6 g ARM Cortex embedded processor running at 800 MHz. Additionally, the effect of x2 feature mapping and opponent-color representations used with these descriptors is examined. These tests are performed on four data sets of varying sizes and difficulty, and the BRIEF descriptor is found to yield the best combination of speed and classification accuracy. Its use with CSL achieves accuracies between 67% and 95% of those achieved with SIFT descriptors and allows for the embedded classification of a 128x192 pixel image in 0.15 seconds, 60 times faster than classification with SIFT. X2 mapping is found to provide substantial improvements in classification accuracy for all of the descriptors at little cost, while opponent-color descriptors are offer accuracy improvements only on colorful datasets.

  12. Optimization of polyhydroxybutyrate production by Bacillus sp. CFR 256 with corn steep liquor as a nitrogen source.

    Science.gov (United States)

    Vijayendra, S V N; Rastogi, N K; Shamala, T R; Anil Kumar, P K; Kshama, L; Joshi, G J

    2007-06-01

    Polyhydroxyalkanotes (PHAs), the eco-friendly biopolymers produced by many bacteria, are gaining importance in curtailing the environmental pollution by replacing the non-biodegradable plastics derived from petroleum. The present study was carried out to economize the polyhydroxybutyrate (PHB) production by optimizing the fermentation medium using corn steep liquor (CSL), a by-product of starch processing industry, as a cheap nitrogen source, by Bacillus sp. CFR 256. Response surface methodology (RSM) was used to optimize the fermentation medium using the variables such as corn steep liquor (5-25 g l(-1)), Na(2)HPO(4) 2H(2)O (2.2-6.2 g l(-1)), KH(2)PO(4) (0.5-2.5 g l(-1)), sucrose (5-55 g l(-1)) and inoculum concentration (1-25 ml l(-1)). Central composite rotatable design (CCRD) experiments were carried out to study the complex interactions of the variables.The optimum conditions for maximum PHB production were (g l(-1)): CSL-25, Na(2)HPO(4) 2H(2)O-2.2, KH(2)PO(4) - 0.5, sucrose - 55 and inoculum - 10 (ml l(-1)). After 72 h of fermentation, the amount of PHA produced was 8.20 g l(-1) (51.20% of dry cell biomass). It is the first report on optimization of fermentation medium using CSL as a nitrogen source, for PHB production by Bacillus sp.

  13. Economic Optimized Medium for Tensio-Active Agent Production by Candida sphaerica UCP0995 and Application in the Removal of Hydrophobic Contaminant from Sand

    Directory of Open Access Journals (Sweden)

    Galba M. Campos-Takaki

    2011-04-01

    Full Text Available Statistical experimental designs and response surface methodology were employed to optimize the concentrations of agroindustrial residues as soybean oil (SORR from refinery, and corn steep liquor (CSL from corn industry, for tensio-active agent produced by Candida sphaerica UCP 0995. Three 22 full factorial design were applied sequentially to investigate the effects of the concentrations and interactions of soybean oil refinery residue and corn steep liquor on the surface tension of free-cell culture broth for 144 h. Two 22 central composite designs and response surface methodology were adopted to derive a statistical model to measure the effect of SORR and CSL on the surface tension of the free-cell culture broth for 144 h. The regression equation obtained from the experimental data using a central composite design was solved, and by analyzing the response surface contour plots, the optimal concentrations of the constituents of the medium were determined: 8.63% v/v (≈9% v/v of SORR and 8.80% v/v (≈9% v/v CSL. The minimum surface tension predicted and experimentally confirmed was 25.25 mN/m. The new biosurfactant, denominated Lunasan, recovered 95% of motor oil adsorbed in a sand sample, thus showing great potential for use in bioremediation processes, especially in the petroleum industry.

  14. The role of target 3D-reconstructions when analysyng qualitative characteristics of the surface of circular-shaped growth in the lungs

    Directory of Open Access Journals (Sweden)

    V. G. Kolmogorov

    2016-01-01

    Full Text Available The purpose of this paper is to improve the accuracy of X-ray diagnostics of circular-shaped growth (CSG by developing computed tomographic semiotics of qualitative characteristics of its surface and the state of the surrounding bronchi using target 3D-reconstruction.Material and methods. 560 patients at the age of 3–89 years were examined. Target 3D reconstruction was carried out with the use of 3D Fly Through program (Toshiba Medical Systems, Japan which removed the tissue surrounding CSG at a distance of 5–10 mm from the outer boundaries.CSG was inscribed into a cube. In case of the primary central and peripheral lung cancer a number of patients with severe rough surface of CSG prevailed over a number of patients with slightly rough surface was detected. In case of infiltrative tuberculosis, pneumonia, echinococcus, retention cysts the prevalence of a number of patients with slightly rough surface of CSG over a number of patients with rough surface was identified. In case of single cancer metastases, single and multiple tuberculomas the prevalence of a number of patients with non-uniform smooth surface of CSG over a number of patients with uniform smooth surface was identified. In case of multiple cancer metastasis, focal tuberculosis, cysticercosis the prevalence of a number of patients with a uniform smooth surface of CSG over a number of patients with uneven smooth surface was identified. In case of benign tumors, eosinophilic infiltrate, gamartohondroma, aspergilloma, chronic abscess, intrapulmonary hematoma there was not difference between the number of patients with a uniform smooth surface of CSG and a number of patients with uneven smooth surface. In case of primary lung cancer metastasis, single and multiple tuberkulomas, echinococcus, cysticercosis there was a prevalence of the number of patients with expressed deformed bronchi surrounding CSL over a number of patients with moderately deformed bronchi. In case of infiltrative

  15. The role of peer assisted learning to improve the effectivity of clinical skill laboratory learning in dental education

    Directory of Open Access Journals (Sweden)

    Agus Ardinansyah

    2016-06-01

    Full Text Available Nowadays, the clinical skill learning in dental education has begun in pre-clinic, known as Clinical Skill Laboratory (CSL which needs human resources, many and expensive tools and manikins, and enough times for practise. One of the method used in CSL in dental education is PeerAssisted Learning (PAL defined as “the development of knowledge and skill through active help and support among status equals or match companions”. This paper aims is to explain the role of PAL method to improve the effectivity of CSL learning in dental education in preclinical stage. Reviewing on the relevant literatures regarding peer assisted learning on the implementation of the clinical skill laboratory in dental education. The effectivity of CSL learning needs close supervision and individual feedback, so enough tutors is important through the process. This PAL method considered to be helpfull with the increasing numbers of dental students and the limitation of staff faculty. This method is found feasible, well accepted by peer-tutors and students, and can be as effective as conventional learning method. This is also useful for peer-teacher because they more intrinsically motivated, have higher conceptual learning scores, and perceive themselves to be more actively engaged with the environment than students who learn in order to be tested.  However, there are several limitation of this method. The contact time between students and medical doctors may decrease significantlyand it does not seem to be generally qualified to transfer such complex procedures.It also needs peer-teachers training and a detailed manual. Questions concerning the cost-effectiveness and profitability of student tutor-guided technical skills training may thus arise. But one institution that implemented this method states that the majority of their tutors decided to continue their teaching activity in the skills lab and that these experienced tutors, in addition to established faculty staff

  16. Quantification of climatic feedbacks on the Caspian Sea level variability and impacts from the Caspian Sea on the large-scale atmospheric circulation

    Science.gov (United States)

    Arpe, Klaus; Tsuang, Ben-Jei; Tseng, Yu-Heng; Liu, Xin-Yu; Leroy, Suzanne A. G.

    2018-05-01

    With a fall of the Caspian Sea level (CSL), its size gets smaller and therefore the total evaporation over the sea is reduced. With a reduced evaporation from the sea, the fall of the CSL is weakened. This creates a negative feedback as less evaporation leads to less water losses of the Caspian Sea (CS). On the other hand, less evaporation reduces the water in the atmosphere, which may lead to less precipitation in the catchment area of the CS. The two opposite feedbacks are estimated by using an atmospheric climate model coupled with an ocean model only for the CS with different CS sizes while keeping all other forcings like oceanic sea surface temperatures (SSTs) and leaf area index the same from a global climate simulation. The investigation is concentrated on the medieval period because at that time the CSL changed dramatically from about - 30 to - 19 m below the mean ocean sea level, partly man-made. Models used for simulating the last millennium are not able to change the size of the CS dynamically so far. When results from such simulations are used to investigate the CSL variability and its causes, the present study should help to parameterize its feedbacks. A first assumption that the total evaporation from the CS will vary with the size of the CS (number of grid points representing the sea) is generally confirmed with the model simulations. The decrease of grid points from 15 to 14, 10, 8 or 7 leads to a decrease of evaporation to 96, 77, 70 and 54%. The lower decrease than initially expected from the number of grid points (93, 67, 53 and 47%) is probably due to the fact that there would also be some evaporation at grid points that run dry with a lower CSL but a cooling of the CS SST with increasing CS size in summer may be more important. The reduction of evaporation over the CS means more water for the budget of the whole catchment of the CS (an increase of the CSL) but from the gain through reduced evaporation over the CS, only 70% is found to remain in

  17. Evidence for inhomogeneous thermal sources of two spike events of 1978, May 5 and December 4

    International Nuclear Information System (INIS)

    Wiehl, H.J.; Desai, U.

    1982-09-01

    Two short duration single spike events of 1978 May 5 and December 4 exhibit similar time profiles in the microwave and hard X-ray ranges, indicating emission from compact sources. Microwave spectral observations exhibit inhomogeneieties present in the source parameters. The existence of fine time structures in the microwave time profiles at 10.4 GHz from Berne are interpreted as a signature of the dynamics of a disturbance travelling through the souce at the ion-sound speed. Stereoscopic observations with the hard X-ray detector on the solar orbiter, Helios-2, and the Berne microwave antennae do not indicate any time lag or differences in the time profiles during the impulsive phase. This is taken as evidence for the absence of directionality of emission making beam models unlikely for short duration single spike events

  18. Particle physics in your pocket!

    CERN Multimedia

    Anaïs Schaeffer

    2012-01-01

    CERN physicists, take out your smartphones! Two new particle physics applications for Android phones have been developed by a physicist from the University of Bern: “Particle Properties” and “Particle Physics Booklet 2010”.   “When I'm on shift, I enjoy looking at the online event displays,” says Igor Kreslo from the Laboratory for High Energy Physics at the University of Bern, the physicist who has developed the two particle physics applications for Android. “Sometimes very beautiful events appear, with many different particles. I like to discuss these displays with my students, just to develop their ability to identify particles. We try to find out which particle is which and how it might decay… I think that's the best way to teach students the phenomenology of particle physics.” When scientists study particle physics, they require some vital information, such as the decay branching ...

  19. 24 weeks of Pilates-aerobic and educative training to improve body fat mass in elderly Serbian women

    Directory of Open Access Journals (Sweden)

    Rutjes AWS

    2014-04-01

    Full Text Available Anne WS Rutjes,1 Marcello Di Nisio2,31Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland; 2Department of Medical, Oral, and Biotechnological Sciences, University G D'Annunzio of Chieti-Pescara, Chieti, Italy; 3Department of Vascular Medicine, Academic Medical Center, Amsterdam, the NetherlandsWe read with interest the article by Ruiz-Montero et al, in which the authors used a before-and-after study design to examine changes in body composition (fat mass and lean body mass related to an aerobic-Pilates program in elderly Serbian women.1 The authors concluded that "a combined program of aerobic and Pilates, carried out under the supervision of an instructor, at least twice a week, produces health benefits in functionally independent women over the age of 60". This conclusion is overly optimistic and not supported by the evidence provided. View original paper by Ruiz-Montero and colleagues.

  20. Comparison of Refractory Performance in Black Liquor Gasifiers and a Smelt Test System

    International Nuclear Information System (INIS)

    Peascoe, RA

    2001-01-01

    Prior laboratory corrosion studies along with experience at the black liquor gasifier in New Bern, North Carolina, clearly demonstrate that serious material problems exist with the gasifier's refractory lining. Mullite-based and alumina-based refractories used at the New Bern facility suffered significant degradation even though they reportedly performed adequately in smaller scale systems. Oak Ridge National Laboratory's involvement in the failure analysis, and the initial exploration of suitable replacement materials, led to the realization that a simple and reliable, complementary method for refractory screening was needed. The development of a laboratory test system and its suitability for simulating the environment of black liquor gasifiers was undertaken. Identification and characterization of corrosion products were used to evaluate the test system as a rapid screening tool for refractory performance and as a predictor of refractory lifetime. Results from the test systems and pl ants were qualitatively similar

  1. Worldline Green functions for multiloop diagrams

    International Nuclear Information System (INIS)

    Schmidt, M.G.; Heidelberg Univ.; Schubert, C.

    1994-03-01

    We propose a multiloop generalization of the Bern-Kosower formalism, based on Strassler's approach of evaluating worldline path integrals by worldline Green functions. Those Green functions are explicitly constructed for the basic two-loop graph, and for a loop with an arbitrary number of propagator insertions. For scalar and abelian gauge theories, the resulting integral representations allow to combine whole classes of Feynman diagrams into compact expressions. (orig.)

  2. Effects of Construction of the Digital Multipurpose Range Complex (DMPRC) on Riparian and Stream Ecosystems at Fort Benning, Georgia. Addendum

    Science.gov (United States)

    2009-06-01

    root dynamics in riparian forests. Soil Science Society of America 69(3):729-737. Houser, J. N., P. J. Mulholland, and K. O. Maloney. 2006. Upland...Forested Wetlands, D. M. Amatya and J. Nettles (eds). New Bern, NC. American Society of Agricultural and Biological Engineers, St. Joseph, MI...primary productivity, vegetation composition, structure, and fine root dynamics in riparian forests. Kelly O. Maloney, Ph.D. in Biological Sciences

  3. Narrative Journalism in the Age of the Internet. New Ways to Create Authenticity in Online Literary Reportages

    Directory of Open Access Journals (Sweden)

    Nora Berning

    2011-11-01

    Full Text Available Online literary reportages represent an imperative counterweight to conventional journalism that is essential both for our emotional and intellectual survival. Using Paula Delgado-Kling’s online literary reportage Child Soldiers: Homero and Mark Bowden’s multimedia text The Desert One Debacle as examples, Nora Berning explores issues of multimediality and authenticity in online narrative journalism. Berning’s case studies open up discussions, both theoretical and practical, about the future of digital media literacy.

  4. Assessment of residency program outcomes via alumni surveys

    Directory of Open Access Journals (Sweden)

    Lüer S

    2017-04-01

    Full Text Available Sonja Lüer, Christoph Aebi Department of Pediatrics, Bern University Hospital, Inselspital, University of Bern, Bern, Switzerland Background: One trend in medical education is outcomes-oriented training. Outcomes usually refer to individuals’ acquisition of competencies, for example, during training in residency programs. However, little is known about outcomes of these programs. In order to fill this gap, human resource (HR data were analyzed and alumni of a pediatric residency program were surveyed at the Department of Pediatrics, Bern University Hospital, Switzerland.Methods: Residency program outcomes (demographics, career choices, part-time or full-time work status, competencies, feedback were assessed through in-house HR databases, publicly available data on the Internet (physician directory and practice homepages, and 2 alumni surveys (S1, S2. Results: In all, 109 alumni met the inclusion criteria. Retention rate at the hospital was low (14%. Forty-six alumni (42% in private practice were eligible for alumni surveys. Response rates were 87% (S1 and 61% (S2. Time intervals between 2 career decisions (selecting specialty of pediatrics vs selecting setting of private practice varied widely (late-training decision to enter private practice. Mean employment level in private practice was 60% (range 20%–100%. Most valued rotation was emergency medicine; most desired competencies in future colleagues were the ability to work in a team, proficiency in pediatrics, and working economically.Conclusion: A broadened view on outcomes – beyond individuals’ competency acquisition – provides informative insights into a training program, can allow for informed program updates, and guide future program development. Keywords: medical education, career choice, pediatrics, private practice

  5. Investigation of Non-Conventional Bio-Derived Fuels for Hybrid Rocket Motors

    Science.gov (United States)

    2007-08-01

    substances (26- 28). The exact chemical composition is dependent on what type of bee produces the beeswax and the type of pollen consumed by the bees ...2007. 27. Bogdanov, Stefan, “Quality and Standards of Pollen and Beeswax,” Swiss Bee Research Centre, Bern Switzerland, 2004. 28. Krell, R. “Value...Digital Ae Nozzle exit cross-sectional area Ap Combustion port cross-sectional area At Nozzle throat cross-sectional area c

  6. DNA fingerprinting in botany: past, present, future

    OpenAIRE

    Nybom, Hilde; Weising, Kurt; Rotter, Björn

    2014-01-01

    Almost three decades ago Alec Jeffreys published his seminal Nature papers on the use of minisatellite probes for DNA fingerprinting of humans (Jeffreys and colleagues Nature 1985, 314:67–73 and Nature 1985, 316:76–79). The new technology was soon adopted for many other organisms including plants, and when Hilde Nybom, Kurt Weising and Alec Jeffreys first met at the very First International Conference on DNA Fingerprinting in Berne, Switzerland, in 1990, everybody was enthusiastic about the n...

  7. Bibliography of Technical Publications and Papers, October 1978 - September 1979

    Science.gov (United States)

    1979-11-01

    WIERBICKI. Thermal processing times and thermodynamic properties of canned meat rolls. Trans. Amer. Soc. Agric. Eng., 21(6): 1242-1245 (1978). 73. DECAREAU...34, Chicago, IL, 20 March 1979. 152. The importance and feasibility of irradiated low nitrite meat products. 33rd Annual Meeting, Research and Development... nitrite in cured meats . Swiss Veterinary Association for Meat Sanitation and Hygiene, Bern, Switzerland, 21 August 1979. 155. , and A. BRYNJOLFSSON. The

  8. Srovnání systémů podpory vývozu v ČR a SRN

    OpenAIRE

    Duchečková, Dana

    2010-01-01

    First part of the theses deals with mutual trade between the Czech Republic and Germany. There are specified single instruments of pro-export policy and importance of the EU, Consensus OECD and the Berne Union in the area of export support. Second part describes export support system in the Czech Republic, its strategy, institutions and offered services. Third part deals with export support in Germany, its programmes and institutions. In forth part, comparison of both export support systems i...

  9. Multiphoton Absorption is Probably Not the Primary Threshold Damage Mechanism for Femtosecond Laser Pulse Exposures in the Retinal Pigment Epithelium

    Science.gov (United States)

    2004-01-01

    Tromberg, and E. Gratton, "Two-photon excited lifetime imaging of autofluorescence in cells during UTVA and NIR photostress", J. Micros. 183, pp. 197-204...1996. 4. K. Konig, Y. Liu, G. J. Sonek, M. W. Berns, and B. J. Tromberg, " Autofluorescence spectroscopy of optically trapped cells", Photochem...34, Photochem. Photobiol. 70, pp. 146-151, 1999. 10. R. D. Glickman, "Phototoxicity to the retina : Mechanisms of damage", International Journal of

  10. Long-term Outcome of Arterial Stroke in Children

    Directory of Open Access Journals (Sweden)

    J Gordon Millichap

    2015-05-01

    Full Text Available Investigators at University Children’s Hospital, Inselspital, and Universities of Bern, Geneva, Basel, and Zurich, Switzerland compared long-term outcome of children (1 month-16 years and young adults (16.1-45 years with arterial ischemic stroke (AIS using prospective data from the Swiss Neuropediatric Stroke Registry and the Adult Bernese stroke registry, between Jan 2000 and Dec 2008.

  11. [Sketches of Swiss psychiatry in the generation after Eugen Bleuler and Sigmund Freud. With personal recollections].

    Science.gov (United States)

    Weber, Kaspar

    2009-01-01

    Focussing on the leading staff of the psychiatric universitiy clinic of Waldau/Bern, the author sketches the reception of psychoanalysis in Switzerland around 1940. It ranged from outright rejection (Ernst Grünthal) via various forms of skepticism based on superficial (Jakob Klaesi) or thorough familiarity with Freud's writings (Jakob Wyrsch, Arnold Weber) to the discipleship of an analysand of Freud (Ernst Blum).

  12. Achievements and Challenges in the Science of Space Weather

    Science.gov (United States)

    Koskinen, Hannu E. J.; Baker, Daniel N.; Balogh, André; Gombosi, Tamas; Veronig, Astrid; von Steiger, Rudolf

    2017-11-01

    In June 2016 a group of 40 space weather scientists attended the workshop on Scientific Foundations of Space Weather at the International Space Science Institute in Bern. In this lead article to the volume based on the talks and discussions during the workshop we review some of main past achievements in the field and outline some of the challenges that the science of space weather is facing today and in the future.

  13. Computer assisted functional analysis. Computer gestuetzte funktionelle Analyse

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, H A.E.; Roesler, H

    1982-01-01

    The latest developments in computer-assisted functional analysis (CFA) in nuclear medicine are presented in about 250 papers of the 19th international annual meeting of the Society of Nuclear Medicine (Bern, September 1981). Apart from the mathematical and instrumental aspects of CFA, computerized emission tomography is given particular attention. Advances in nuclear medical diagnosis in the fields of radiopharmaceuticals, cardiology, angiology, neurology, ophthalmology, pulmonology, gastroenterology, nephrology, endocrinology, oncology and osteology are discussed.

  14. Radiokrypton dating coming of age

    Institute of Scientific and Technical Information of China (English)

    Zheng-Tian Lu

    2016-01-01

    The dream of radiokrypton dating began in 1969 when Heinz Hugo Loosli and Hans Oeschger of the University of Bern first detected the decay of81Rr(half-life=230 000 yr)in krypton gas extracted from air[1].This isotope is produced in the upper atmosphere by cosmic-ray-induced spallation and neutron-activation of stable krypton.Due to its long residence time(105 yr)in the atmosphere,81Rr is uniformly

  15. First runs with the ORPHEUS dark matter detector

    CERN Document Server

    Czapek, G; Hauser, M; Janos, S; Loaiza, P; Moser, U; Pretzl, K; Brandt, B V D; Konter, J A; Mango, S; Ebert, T; Kainer, K U; Knoop, K M

    2002-01-01

    The ORPHEUS dark matter experiment is completed at our shallow depth laboratory in Bern (70 m.w.e.). The detector relies on measuring the magnetic flux variation produced by weakly interacting massive particles (WIMPs) as they heat 30 mu m diameter superheated superconducting tin granules (SSG) and induce superconducting-to-normal phase transitions. In an initial phase, 0.45 kg of tin granules in a segmented detector volume have been used. Preliminary results of the experiment will be reported.

  16. Biomedical Studies with the Free Electron Laser

    Science.gov (United States)

    1989-05-15

    and Berns. Mi. W. User pitotora- 26. Kestel. D.. And Chou. T. C. Tumer -localizing components of the ptirph% rin diation therapy of cancer following... cancer , (2) laser tissue interactions for the study of atherosclerosis, (3) pulsed laser effects on the eye, (4) laser application in genetic...these studies. Please refer to the appropriate article/abstract for further detail. 1. Dye plus laser photosensitization of cancer . Significant

  17. Photon Splitting in a Strong Magnetic Field: Recalculation and Comparison with Previous Calculations

    International Nuclear Information System (INIS)

    Adler, S.L.; Schubert, C.

    1996-01-01

    We recalculate the amplitude for photon splitting in a strong magnetic field below the pair production threshold, using the world line path integral variant of the Bern-Kosower formalism. Numerical comparison (using programs that we have made available for public access on the Internet) shows that the results of the recalculation are identical to the earlier calculations of Adler and later of Stoneham, and to the recent recalculation by Baier, Milstein, and Shaisultanov. copyright 1996 The American Physical Society

  18. Clausewitzian Friction and Future War Revised Edition

    Science.gov (United States)

    2004-01-01

    Hanoverian general Rudolf von Hammerstein was ordered to occupy the town of Menin in southern Belgium, Scharnhorst served as his principal staff offi...their own files. 100 ENDNOTES FOR PAGES 38–41 156 The intractability of the traveling salesman, or Steiner shortest network, problem is as fol- lows...the class of “hard” problems epitomized by the Steiner problem remains “the preeminent problem in theoretical computer science” (Marshall W. Bern and

  19. Stress and burnout among Swiss dental residents

    OpenAIRE

    Divaris, Kimon; Lai, Caroline S; Polychronopoulou, Argy; Eliades, Theodore; Katsaros, Christos

    2012-01-01

    Stress and burnout have been well-documented in graduate medical and undergraduate dental education, but studies among dental graduate students and residents are sparse. The purpose of this investigation was to examine perceived stressors and three dimensions of burnout among dental residents enrolled in the University of Bern, Switzerland. Thirty-six residents enrolled in five specialty programmes were administered the Graduate Dental Environment Stress (GDES30) questionnaire and the Maslach...

  20. Games people play the psychology of human relationships

    CERN Document Server

    Berne, Eric

    2010-01-01

    The bestselling Games People Play is the book that has helped millions of people understand the dynamics of relationships, by psychiatrist Eric Berne.We all play games. In every encounter with other people we are doing so. The nature of these games depends both on the situation and on who we meet.Eric Berne's classic Games People Play is the most accessible and insightful book ever written about the games we play: those patterns of behaviour that reveal hidden feelings and emotions. Wise and witty, it shows the underlying motivations behind our relationships and explores the roles that we try to play - and are forced to play.Games People Play gives you the keys to unlock the psychology of others - and yourself. You'll become more honest, more effective, and a true team player.'A brilliant, amusing, and clear catalogue of the psychological theatricals that human beings play over and over again' Kurt VonnegutEric Berne was a prominent psychiatrist and bestselling author.After inventing his groundbreaking Transa...

  1. Long-term performance of borehole heat exchangers. A project conducted at the Burgdorf engineering school, Switzerland; Langzeitverhalten von Erdwaermesonden am Beispiel des Projektes an der Ingenieurschule Burgdorf (CH)

    Energy Technology Data Exchange (ETDEWEB)

    Berdat, F. [Wasser- und Energiewirtschaftsamt, Bern (Switzerland)

    1997-12-01

    In 1981, the canton of Bern passed modern energy legislation. It promotes, for instance, the harnessing of thermal energy in the environment. The canton has made great efforts to strengthen knowledge of the use of water and the ground as sources of thermal energy. From 1985 to 1995, six so-called `Thermo Programmes` with a total cost of around 9.5 million Swiss Francs were carried out. They made essential contributions to the understanding of thermal energy flow, the making-up of thermal energy budgets and, thereby, to the assessment of the useful thermal energy potentials of water and the ground. The last and, at the same time, most comprehensive project was the `thermo programme borehole heat exchangers` conducted at the canton`s engineering school (technical school) at Burgdurf. (orig.) [Deutsch] Im Jahr 1981 wurde im Kanton Bern ein modernes Energiegesetz eingefuehrt. Unter anderem foerdert es die Nutzung der Umgebungswaerme. Deshalb hat der Kanton Bern grosse Anstrengungen unternommen, das Wissen um die Nutzung von Wasser und Boden als Waermequelle zu festigen. In den Jahren 1985-1995 wurden sechs sogenannte `Thermoprogramme` durchgefuehrt, die zusammen rund 9.5 Mio. Franken gekostet und wesentlich zum Verstaendnis der Waermestroeme, zur Erstellung von Waermebilanzen und damit zur Ermittlung der nutzbaren Waermepotentiale von Wasser und Boden beigetragen haben. Das letzte und gleichzeitig umfangreichste Projekt war das `Thermoprogramm Erdwaermesonden` an der kantonalen Ingenieurschule Burgdorf (FH). (orig.)

  2. If Hunters End Up in the Emergency Room: A Retrospective Analysis of Hunting Injuries in a Swiss Emergency Department

    Directory of Open Access Journals (Sweden)

    Valentina Bestetti

    2015-01-01

    Full Text Available Aim. to characterize the mechanisms, patterns, and outcomes of nonfatal hunting-related injuries in patients presenting to Bern University Hospital, Switzerland, and compare these to reports of hunting injuries worldwide. Methods. patients presenting with hunting-related injuries to the Emergency Department at Bern University hospital from 2000 to 2014 were identified by retrospectively searching the department database using the keyword “hunt.” Each case was analyzed in terms of the patient age and gender, the mechanism and pattern of injury, and management and patient follow-up. Results. 19 patients were identified. 16 were male with a mean age of 50 years (range: 16–74. Mechanisms of injury included firearm-related injuries, falls, and knife wounds. The most common patterns of injury were head injuries (7, followed by injuries to the upper (5 or lower limb (5 and trunk (2. Over half of the patients were admitted, and nine required emergency surgery. Conclusion. Nonfatal hunting accidents in Bern, Switzerland, are largely caused by firearms and falls and tend to occur in male hunters with a mean age of 50 years. The most common patterns of injury are orthopedic and head injuries, often requiring surgery. These findings are consistent with international studies of nonfatal hunting accidents.

  3. Stress, burnout and health in the clinical period of dental education.

    Science.gov (United States)

    Pöhlmann, K; Jonas, I; Ruf, S; Harzer, W

    2005-05-01

    The study examined the extent of stress, burnout and health problems experienced by fourth and fifth year dental students from the three universities of Dresden, Freiburg and Bern. The objectives of the study were to: (i) identify frequent sources of stress and to report the prevalence rates of burnout and health problems in dental students, (ii) determine the rate of students suffering from severe burnout symptoms and (iii) identify stress factors related to the burnout symptoms of emotional exhaustion and depersonalization. A total of 161 dental students from Dresden, Freiburg and Bern participated in the study. They completed the Psychosocial Stress Inventory, the Maslach Burnout Inventory and the Health Survey Questionnaire. Frequent sources of stress were limitation of leisure time, examination anxiety and the transition stress that was related to the adaptation to the demands of the clinical phase of dental education. Few differences existed between the students of the fourth and the fifth study year. Study-related stress was lowest in Bern and considerably higher in Dresden. Differences of mean levels of burnout symptoms were found only for the burnout dimension of emotional exhaustion. Students from Dresden and Freiburg were more emotionally exhausted than students from Bern, students from Dresden also reported more health problems than students from Bern or Freiburg. Ten per cent of the dental students suffered from severe emotional exhaustion, 17% complained about a severe lack of accomplishment and 28% reported severe depersonalization symptoms. Forty-four per cent of the variance of emotional exhaustion was explained by study-related factors such as lack of leisure time, examination anxiety and transition stress. The only predictor of depersonalization was a lack of social integration, accounting for 3% of the variance. A lack of social integration may be an indicator of low social competence which may cause difficulties in dealing with patients

  4. Dynamical simulation of structural multiplicity in grain boundaries

    International Nuclear Information System (INIS)

    Majid, I.; Bristowe, P.D.

    1987-06-01

    Work on a computer simulation study of a low-energy high-angle boundary structure which is not periodic have been recently reported. This result is of interest since grain boundary structures are usually assumed to have a periodicity corresponding to the appropriate coincidence site lattice (CSL) and many experimental observations of the structure of grain boundaries performed using conventional and high-resolution electron microscopy, electron diffraction and x-ray diffraction appear to support this work. However, this work, using empirical interatomic pair potentials and the relaxation method of molecular statics, have simulated a Σ = 5 36.87 0 (001) twist boundary and found a low energy structure having a larger repeat cell than the CSL and is composed of two different types of structural unit that are randomly distributed in the boundary plane. This result, which has been termed the multiplicity of grain boundary structures, has also been found in the simulation of tilt boundaries. The multiplicity phenomenon is of special interest in twist boundaries since it is used as a structural model to explain the x-ray scattering from a Σ = 5 boundary in gold. These scattering patterns had previously remained unexplained using stable structures that had simple CSL periodicity. Also, the effect of having a multiple number of low energy structural units coexisting in the grain boundary is of more general interest since it implies that the boundary structures may be quasi-periodic and, in some circumstances, may even result in a roughening of the boundary plane. This paper extends this work by showing, using molecular dynamics, that a multiplicity of structural units can actually nucleate spontaneously in a high-angle grain boundary at finite temperatures

  5. Functional changes in people with different hearing status and experiences of using Chinese sign language: an fMRI study.

    Science.gov (United States)

    Li, Qiang; Xia, Shuang; Zhao, Fei; Qi, Ji

    2014-01-01

    The purpose of this study was to assess functional changes in the cerebral cortex in people with different sign language experience and hearing status whilst observing and imitating Chinese Sign Language (CSL) using functional magnetic resonance imaging (fMRI). 50 participants took part in the study, and were divided into four groups according to their hearing status and experience of using sign language: prelingual deafness signer group (PDS), normal hearing non-signer group (HnS), native signer group with normal hearing (HNS), and acquired signer group with normal hearing (HLS). fMRI images were scanned from all subjects when they performed block-designed tasks that involved observing and imitating sign language stimuli. Nine activation areas were found in response to undertaking either observation or imitation CSL tasks and three activated areas were found only when undertaking the imitation task. Of those, the PDS group had significantly greater activation areas in terms of the cluster size of the activated voxels in the bilateral superior parietal lobule, cuneate lobe and lingual gyrus in response to undertaking either the observation or the imitation CSL task than the HnS, HNS and HLS groups. The PDS group also showed significantly greater activation in the bilateral inferior frontal gyrus which was also found in the HNS or the HLS groups but not in the HnS group. This indicates that deaf signers have better sign language proficiency, because they engage more actively with the phonetic and semantic elements. In addition, the activations of the bilateral superior temporal gyrus and inferior parietal lobule were only found in the PDS group and HNS group, and not in the other two groups, which indicates that the area for sign language processing appears to be sensitive to the age of language acquisition. After reading this article, readers will be able to: discuss the relationship between sign language and its neural mechanisms. Copyright © 2014 Elsevier Inc

  6. Biomimetic fiber assembled gradient hydrogel to engineer glycosaminoglycan enriched and mineralized cartilage: An in vitro study.

    Science.gov (United States)

    Mohan, Neethu; Wilson, Jijo; Joseph, Dexy; Vaikkath, Dhanesh; Nair, Prabha D

    2015-12-01

    The study investigated the potential of electrospun fiber assembled hydrogel, with physical gradients of chondroitin sulfate (CS) and sol-gel-derived bioactive glass (BG), to engineer hyaline and mineralized cartilage in a single 3D system. Electrospun poly(caprolactone) (PCL) fibers incorporated with 0.1% w/w of CS (CSL) and 0.5% w/w of CS (CSH), 2.4% w/w of BG (BGL) and 12.5% w/w of BG (BGH) were fabricated. The CS showed a sustained release up to 3 days from CSL and 14 days from CSH fibers. Chondrocytes secreted hyaline like matrix with higher sulfated glycosaminoglycans (sGAG), collagen type II and aggrecan on CSL and CSH fibers. Mineralization was observed on BGL and BGH fibers when incubated in simulated body fluid for 14 days. Chondrocytes cultured on these fibers secreted a mineralized matrix that consisted of sGAG, hypertrophic proteins, collagen type X, and osteocalcin. The CS and BG incorporated PCL fiber mats were assembled in an agarose-gelatin hydrogel to generate a 3D hybrid scaffold. The signals in the fibers diffused and generated continuous opposing gradients of CS (chondrogenic signal) and BG (mineralization) in the hydrogel. The chondrocytes were encapsulated in hybrid scaffolds; live dead assay at 48 h showed viable cells. Cells maintained their phenotype and secreted specific extracellular matrix (ECM) in response to signals within the hydrogel. Continuous opposing gradients of sGAG enriched and mineralized ECM were observed surrounding each cell clusters on gradient hydrogel after 14 days of culture in response to the physical gradients of raw materials CS and BG. A construct with gradient mineralization might accelerate integration to subchondral bone during in vivo regeneration. © 2015 Wiley Periodicals, Inc.

  7. Proteasas alcalinas de una cepa nativa de Bacillus sp Alcalofílico Proteasas alcalinas de una cepa nativa de Bacillus sp Alcalofílico

    Directory of Open Access Journals (Sweden)

    A. Sáez Vega

    2006-06-01

    Full Text Available Se evaluó el efecto de cuatro fuentes de nitrógeno sobre la actividad enzimática de proteasas alcalinas, secretadas por una cepa nativa de Bacillus sp Alcalofílico, cultivada a diferentes concentraciones de LMF (Licor de Maíz Fermentado. El crecimiento de la cepa no es afectado por los pH de inoculación de 7,0; 8,5 y 9,5; en contraste con la actividad enzimática y producción de proteína verdadera, que tuvieron sus mejores resultados a pH inicial de 8,5. A este pH se evaluaron dos fuentes de nitrógeno orgánico (extracto de levadura y peptona y dos inorgánicos (NH4Cl y NaNO3The effect of four nitrogen sources on the enzymatic activity of alkaline proteases from a wild strain of Alkalophilic Bacillus sp cultivated to different concentrations from CSL (Corn Steep Liquor. was evaluated. The growth of the strain is not affected by pH of inoculation of 7,0, 8,5 and 9,5, in contrast to the enzymatic activity and true protein production, that had their better results to initial pH of 8,5. To this initial pH of 8,5; two organic nitrogen sources (yeast extract and peptone and two inorganic ones were evaluated (NH4Cl and NaNO3. With peptone the best enzymatic activity to a relation appeared to molar C/N between 1 and 2 was found. For the studied interval of % CSL (0,5 to 2% p/v the concentration of the CSL does not affect the enzymatic activity.

  8. State vector reduction - 2: Elements of physical reality, nonlocality and stochasticity in relativistic dynamical reduction models

    International Nuclear Information System (INIS)

    Ghirardi, G.C.; Pearle, P.

    1991-02-01

    The problem of getting a relativistic generalization of the CSL dynamical reduction model, which has been presented in part I, is discussed. In so doing we have the opportunity to introduce the idea of a stochastically invariant theory. The theoretical model we present, that satisfies this kind of invariance requirement, offers us the possibility to reconsider, from a new point of view, some conceptually relevant issues such as nonlocality, the legitimacy of attributing elements of physical reality to physical systems and the problem of establishing causal relations between physical events. (author). Refs, 3 figs

  9. Immunoglobulin G for patients with necrotising soft tissue infection (INSTINCT)

    DEFF Research Database (Denmark)

    Madsen, Martin B.; Hjortrup, Peter B.; Hansen, Marco B.

    2017-01-01

    Purpose: The aim of the INSTINCT trial was to assess the effect of intravenous polyspecific immunoglobulin G (IVIG) compared with placebo on self-reported physical function in intensive care unit (ICU) patients with necrotising soft tissue infection (NSTI). Methods: We randomised 100 patients...... with NSTI 1:1 to masked infusion of 25 g of IVIG (Privigen, CSL Behring) or an equal volume of 0.9% saline once daily for the first 3 days of ICU admission. The primary outcome was the physical component summary (PCS) score of the 36-item short form health survey (SF-36) 6 months after randomisation...

  10. Effect of aflatoxin B1 on growth and enzymatic activity of a native strain of Bacillus sp

    Directory of Open Access Journals (Sweden)

    Alex Sáez Vega

    2004-01-01

    Full Text Available The effect of different aflatoxin B1 (AFAB1 concentrations on alkaline protease growth and enzymatic activity was evaluated; a native strain of alkalophilic Bacillus sp cultivated in CSL (Corn Steep Liquor was used. It was found that the effect of AFAB1 on the strain inhibited its growth and enzymatic activity to 1 ppm, showing that the strain is highly sensible to AFAB1, meaning that medium obtained f rom Colombian corn contaminated with this mycotoxin cannot be easily used. Concentrations less than 0.1 ppm did not affect growth and enzymatic activity. Key words: Bacillus, aflatoxin, alkaline proteases.

  11. 6. Radiopharmaceuticals

    International Nuclear Information System (INIS)

    Schiller, P.; Havranek, E.; Majer, J.

    1981-01-01

    Radionuclides commonly used in medicine are surveyed and their nuclear characteristics are presented. The methods are given of their preparation, most frequent use and detection. The list is given of radiopharmaceuticals included in the Czechoslovak Pharmacopoeia CsL 3 , ie., sodium chromate( 51 Cr), sodium iodide( 131 I), hippuran( 131 I), sodium phosphate( 32 P), colloidal gold( 198 Au), rose bengal sodium salt( 131 I), and sodium pertechnetate(sup(99m)Tc) injections. Characteristics, chemical preparation, identification tests, packaging, storage, application and dosage are shown for each preparation. Also listed are important unofficial radiopharmaceuticals, their main characteristics and data on their preparation and application. (B.S.)

  12. State vector reduction - 1: Dynamical reduction theories; changing quantum theory so the statevector represents reality

    International Nuclear Information System (INIS)

    Ghirardi, G.C.; Pearle, P.

    1991-02-01

    The propositions, that what we see around us is real and that reality should be represented by the statevector, conflict with quantum theory. In quantum theory, the statevector can readily become a sum of states of comparable norm, each state representing a different reality. In this paper we present the Continuous Spontaneous Localization (CSL) theory, in which a modified Schroedinger equation, while scarcely affecting the dynamics of a microscopic system, rapidly ''reduces'' the statevector of a macroscopic system to a state appropriate for representing individual reality. (author). Refs

  13. Daddy’s Car: Artificial Intelligence as a Creative Tool for Copyright

    Directory of Open Access Journals (Sweden)

    Jaime Alberto Díaz Limón

    2016-12-01

    Full Text Available This year on September 19th, Sony CSL, a software developer company, announced to the world, the creation of the first musical work whose ownership belongs to Artificial Intelligence. This paper analyzes the legal consequences of such a statement, and it’s conceptual and legal limits within the Copyright Universe (with fundament on International Treaties; in order to assess whether we are in presence of new legal-authorial figure that invite us to think over the subjects of protection in our laws or whether the applicable normativity may resolve these hypotheses in favor Artificial Intelligence, instead of juridical persons.

  14. Brewer’s spent grain and corn steep liquor as alternative culture medium substrates for proteinase production by Streptomyces malaysiensis AMT-3

    Science.gov (United States)

    do Nascimento, Rodrigo Pires; Junior, Nelson Alves; Coelho, Rosalie Reed Rodrigues

    2011-01-01

    Brewer’s spent grain and corn steep liquor or yeast extract were used as the sole organic forms for proteinase production by Streptomyces malaysiensis in submerged fermentation. The influence of the C and N concentrations, as well as the incubation periods, were assessed. Eight proteolytic bands were detected through gelatin-gel-electrophoresis in the various extracts obtained from the different media and after different incubation periods, with apparent molecular masses of 20, 35, 43, 50, 70, 100, 116 and 212 kDa. The results obtained suggest an opportunity for exploring this alternative strategy for proteinases production by actinomycetes, using BSG and CSL as economically feasible substrates. PMID:24031767

  15. Critical Science Education in a Suburban High School Chemistry Class

    Science.gov (United States)

    Ashby, Patrick

    To improve students' scientific literacy and their general perceptions of chemistry, I enacted critical chemistry education (CCE) in two "regular level" chemistry classes with a group of 25 students in a suburban, private high school as part of this study. CCE combined the efforts of critical science educators (Fusco & Calabrese Barton, 2001; Gilbert 2013) with the performance expectations of the Next Generation Science Standards (NGSS) (NGSS Lead States, 2013a) to critically transform the traditional chemistry curriculum at this setting. Essentially, CCE engages students in the critical exploration of socially situated chemistry content knowledge and requires them to demonstrate this knowledge through the practices of science. The purpose of this study was to gauge these students development of chemistry content knowledge, chemistry interest, and critical scientific literacy (CSL) as they engaged in CCE. CSL was a construct developed for this study that necessarily combined the National Research Center's (2012) definition of scientific literacy with a critical component. As such, CSL entailed demonstrating content knowledge through the practices of science as well as the ability to critically analyze the intersections between science content and socially relevant issues. A mixed methods, critical ethnographic approach framed the collection of data from open-ended questionnaires, focus group interviews, Likert surveys, pre- and post unit tests, and student artifacts. These data revealed three main findings: (1) students began to develop CSL in specific, significant ways working through the activities of CCE, (2) student participants of CCE developed a comparable level of chemistry content understanding to students who participated in a traditional chemistry curriculum, and (3) CCE developed a group of students' perceptions of interest in chemistry. In addition to being able to teach students discipline specific content knowledge, the implications of this study are

  16. “Citation Style Language” Uygulaması: APA Kaynak Gösterme Biçiminin Türkçeye Adaptasyonu=“Citation Style Language” Application: The Adaptation of APA Style to Turkish Language

    Directory of Open Access Journals (Sweden)

    Kasım Binici

    2013-10-01

    Full Text Available Bibliyografya yönetim programları, araştırma metinlerin yazımında yazarlara büyük avantajlar sağlamaktadır.Akademik çevrede EndNote, RefWorks, Zotero, Mendeley en popüler yazılımlardır. Türkçe kaynak gösterme kurallarının tanımlı olduğu biçim dosyalarının olmaması nedeniyle araştırma metni yazımında bu programlar işlevsiz kalmaktadır. Bu çalışmada, APA kaynak gösterme biçiminin Türkçeye adaptasyonu sağlanarak CSL uygulaması ile biçim dosyasında kodlar yazılmıştır. Yeni biçim dosyası Zotero ve Mendeley programlarında çalışabilirliği test edilerek kişilerin kullanımına sunulmuştur. Çalışma neticesinde oluşturulan APA-TR dosyası sayesinde Türkçe araştırma metinlerinin yazımında CSL uygulamasını tercih eden bibli- yografya yönetim yazılımların kullanımı mümkün olmuştur./Bibliography managment tools provide great advantage for researchers with writing their articles or research papers. In academic environment, EndNote, RefWorks, Zotero, Mendeley are the most popular software programms. Due to the lack of style files in which citation rules in Turkish language are described,these softwares stay functionless. In this study by providing turkish adaptation of APA citation style, new codes were written into the style file via CSL application. New style file is presented to users after testing its workability in Zotero and Mendeley programms. Thanks to APA-TR style file created as a result of the study,it is possibble to use bibliography managment tools which prefer CSL application in writing research papers Turkish language.

  17. Impacts and adaptation of the cropping systems to climate change in the Northeast Farming Region of China

    DEFF Research Database (Denmark)

    Yin, Xiaogang; Olesen, Jørgen Eivind; Wang, M.

    2016-01-01

    The Northeast Farming Region of China (NFR) is a very important crop growing area, comprising seven sub-regions: Xing’anling (XA), Sanjiang (SJ), Northwest Songliao (NSL), Central Songliao (CSL), Southwest Songliao (SSL), Changbaishan (CB) and Liaodong (LD), which has been severely affected...... to become more severe for crop production under climate change. Adaptation measures that have already been implemented in recent decades to cope with current climatic limitations include changes in timing of cultivation, variety choice, soil tillage practices, crop protection, irrigation and use of plastic...

  18. OPTIMIZATION OF ATM AND BRANCH CASH OPERATIONS USING AN INTEGRATED CASH REQUIREMENT FORECASTING AND CASH OPTIMIZATION MODEL

    OpenAIRE

    Canser BİLİR

    2018-01-01

    In this study, an integrated cash requirement forecasting and cash inventory optimization model is implemented in both the branch and automated teller machine (ATM) networks of a mid-sized bank in Turkey to optimize the bank’s cash supply chain. The implemented model’s objective is to minimize the idle cash levels at both branches and ATMs without decreasing the customer service level (CSL) by providing the correct amount of cash at the correct location and time. To the best of our knowledge,...

  19. Basic Expeditionary Airfield Resource (BEAR) Requirements Analysis Tool (BRAT)

    Science.gov (United States)

    2008-01-01

    analytical methods used to determine the quantity of BEAR assets needed to meet future requirements. Hunt 6 The SSSP documentation should be finalized...Personnel Bins Warning or Notification Time This variable directly relates to the transportation methods available to transport BEAR, as well as the...Avlll.bIt 3,109,596 FFI YIS Avllllblt VIS ~ i7 ATAR CSl MNlllni. Low CIviliIn No lImlttd .lImittd Nonl ’Non, 4I3,OOO:VRF YIS lkoknown Y,. !J;..~~ ~B

  20. Enhanced production and characterization of a novel β- D-glucose ...

    African Journals Online (AJOL)

    Optimum production of glucose oxidase from A. niger UV-180-C was carried out by using CSL (2%), fermentation period (36 h), pH (5.5 and 4.5 for wild and mutant respectively), temperature (30°C), MgSO4.7H2O (0.0%), CaCO3 (0.1%), KH2PO4 (0.8 and 1.0% for wild and mutant strains), Urea (0.3%). Crude enzyme was ...

  1. Batch fermentation of whey ultra filtrate by Lactobacillus helveticus for lactic acid production

    Energy Technology Data Exchange (ETDEWEB)

    Roy, D; Goulet, J; Le Duy, Q

    1986-06-01

    Cheese whey ultrafiltrate (WU) was used as the carbon source for the production of lactic acid by batch fermentation with Lactobacillus helveticus strain milano. The fermentation was conducted in a 400 ml fermentor at an agitation rate of 200 revolutions per minute and under conditions of controlled temperature (42 degrees C) and pH. In the whey ultrafiltrate-corn steep liquor (WU-CSL) medium, the optimal pH for fermentation was 5.9. Inoculum propagated in skim milk (SM) medium or in lactose synthetic (LS) medium resulted in the best performance in fermentation (in terms of growth, lactic acid production, lactic acid yield and maximum productivity of lactic acid), as compared to that propagated in glucose synthetic (GS) medium. The yeast extract ultrafiltrate (YEU) used as the nitrogen/growth factor source in the WU medium at 1.5% (w/v) gave the highest maximum productivity of lactic acid of 2.70 g/l-h, as compared to the CSL and the tryptone ultrafiltrate (TU). 27 references.

  2. Shell occupation by the hermit crab Dardanus insignis (Decapoda, Diogenidae from the north Coast of São Paulo state, Brazil

    Directory of Open Access Journals (Sweden)

    I. F. Frameschi

    Full Text Available Abstract The pattern of shell occupation by the hermit crab Dardanus insignis (Saussure, 1858 from the subtropical region of southeastern coast of Brazil was investigated in the present study. The percentage of shell types that were occupied and the morphometric relationships between hermit crabs and occupied shells were analyzed from monthly collections conducted during two years (from January 1998 to December 1999. Individuals were categorized according to sex and gonadal maturation, weighed and measured with respect to their cephalothoracic shield length (CSL and wet weight (CWW. Shells were measured regarding their aperture width (SAW, dry weight (SDW and internal volume (SIV. A total of 1086 hermit crabs was collected, occupying shells of 11 gastropod species. Olivancillaria urceus (Roding, 1798 was most commonly used by the hermit crab D. insignis, followed by Buccinanops cochlidium (Dillwyn, 1817, and Stramonita haemastoma (Linnaeus, 1767. The highest determination coefficients (r2 > 0.50, p < 0.01 were recorded particularly in the morphometric relationships between CSL vs. CWW and SAW vs. SIV, which are important indication that in this D. insignis population the great majority the animals occupied adequate shells during the two years analysed. The high number of used shell species and relative plasticity in pattern of shell utilization by smaller individuals of D. insignis indicated that occupation is influenced by the shell availability, while larger individuals demonstrated more specialized occupation in Tonna galea (Linnaeus, 1758 shell.

  3. Laccase production by Coriolopsis caperata RCK2011: Optimization under solid state fermentation by Taguchi DOE methodology

    Science.gov (United States)

    Nandal, Preeti; Ravella, Sreenivas Rao; Kuhad, Ramesh Chander

    2013-01-01

    Laccase production by Coriolopsis caperata RCK2011 under solid state fermentation was optimized following Taguchi design of experiment. An orthogonal array layout of L18 (21 × 37) was constructed using Qualitek-4 software with eight most influensive factors on laccase production. At individual level pH contributed higher influence, whereas, corn steep liquor (CSL) accounted for more than 50% of the severity index with biotin and KH2PO4 at the interactive level. The optimum conditions derived were; temperature 30°C, pH 5.0, wheat bran 5.0 g, inoculum size 0.5 ml (fungal cell mass = 0.015 g dry wt.), biotin 0.5% w/v, KH2PO4 0.013% w/v, CSL 0.1% v/v and 0.5 mM xylidine as an inducer. The validation experiments using optimized conditions confirmed an improvement in enzyme production by 58.01%. The laccase production to the level of 1623.55 Ugds−1 indicates that the fungus C. caperata RCK2011 has the commercial potential for laccase. PMID:23463372

  4. Random Forest-Based Recognition of Isolated Sign Language Subwords Using Data from Accelerometers and Surface Electromyographic Sensors.

    Science.gov (United States)

    Su, Ruiliang; Chen, Xiang; Cao, Shuai; Zhang, Xu

    2016-01-14

    Sign language recognition (SLR) has been widely used for communication amongst the hearing-impaired and non-verbal community. This paper proposes an accurate and robust SLR framework using an improved decision tree as the base classifier of random forests. This framework was used to recognize Chinese sign language subwords using recordings from a pair of portable devices worn on both arms consisting of accelerometers (ACC) and surface electromyography (sEMG) sensors. The experimental results demonstrated the validity of the proposed random forest-based method for recognition of Chinese sign language (CSL) subwords. With the proposed method, 98.25% average accuracy was obtained for the classification of a list of 121 frequently used CSL subwords. Moreover, the random forests method demonstrated a superior performance in resisting the impact of bad training samples. When the proportion of bad samples in the training set reached 50%, the recognition error rate of the random forest-based method was only 10.67%, while that of a single decision tree adopted in our previous work was almost 27.5%. Our study offers a practical way of realizing a robust and wearable EMG-ACC-based SLR systems.

  5. Diachronic changes in word probability distributions in daily press

    Directory of Open Access Journals (Sweden)

    Stanković Jelena

    2006-01-01

    Full Text Available Changes in probability distributions of individual words and word types were investigated within two samples of daily press in the span of fifty years. Two samples of daily press were used in this study. The one derived from the Corpus of Serbian Language (CSL /Kostić, Đ., 2001/ that covers period between 1945. and 1957. and the other derived from the Ebart Media Documentation (EBR that was complied from seven daily news and five weekly magazines from 2002. and 2003. Each sample consisted of about 1 million words. The obtained results indicate that nouns and adjectives were more frequent in the CSL, while verbs and prepositions are more frequent in the EBR sample, suggesting a decrease of sentence length in the last five decades. Conspicuous changes in probability distribution of individual words were observed for nouns and adjectives, while minimal or no changes were observed for verbs and prepositions. Such an outcome suggests that nouns and adjectives are most susceptible to diachronic changes, while verbs and prepositions appear to be resistant to such changes.

  6. Industrial vitamin B12 production by Pseudomonas denitrificans using maltose syrup and corn steep liquor as the cost-effective fermentation substrates.

    Science.gov (United States)

    Xia, Wei; Chen, Wei; Peng, Wei-Fu; Li, Kun-Tai

    2015-06-01

    The aerobic Pseudomonas denitrificans is widely used for industrial and commercial vitamin B12 fermentation, due to its higher productivity compared to the anaerobic vitamin B12-producing microorganisms. This paper aimed to develop a cost-effective fermentation medium for industrial vitamin B12 production by P. denitrificans in 120,000-l fermenter. It was found that maltose syrup (a low-cost syrup from corn starch by means of enzymatic or acid hydrolysis) and corn steep liquor (CSL, a by-product of starch industry) were greatly applicable to vitamin B12 production by P. denitrificans. Under the optimal fermentation medium performed by response surface methodology, 198.27 ± 4.60 mg/l of vitamin B12 yield was obtained in 120,000-l fermenter, which was close to the fermentation with the refined sucrose (198.80 mg/l) and was obviously higher than that obtained under beet molasses utilization (181.75 mg/l). Therefore, maltose syrups and CSL were the efficient and economical substrates for industrial vitamin B12 fermentation by P. denitrificans.

  7. Comparative studies of the venom of a new Taipan species, Oxyuranus temporalis, with other members of its genus.

    Science.gov (United States)

    Barber, Carmel M; Madaras, Frank; Turnbull, Richard K; Morley, Terry; Dunstan, Nathan; Allen, Luke; Kuchel, Tim; Mirtschin, Peter; Hodgson, Wayne C

    2014-07-02

    Taipans are highly venomous Australo-Papuan elapids. A new species of taipan, the Western Desert Taipan (Oxyuranus temporalis), has been discovered with two specimens housed in captivity at the Adelaide Zoo. This study is the first investigation of O. temporalis venom and seeks to characterise and compare the neurotoxicity, lethality and biochemical properties of O. temporalis venom with other taipan venoms. Analysis of O. temporalis venom using size-exclusion and reverse-phase HPLC indicated a markedly simplified "profile" compared to other taipan venoms. SDS-PAGE and agarose gel electrophoresis analysis also indicated a relatively simple composition. Murine LD50 studies showed that O. temporalis venom is less lethal than O. microlepidotus venom. Venoms were tested in vitro, using the chick biventer cervicis nerve-muscle preparation. Based on t90 values, O. temporalis venom is highly neurotoxic abolishing indirect twitches far more rapidly than other taipan venoms. O. temporalis venom also abolished responses to exogenous acetylcholine and carbachol, indicating the presence of postsynaptic neurotoxins. Prior administration of CSL Taipan antivenom (CSL Limited) neutralised the inhibitory effects of all taipan venoms. The results of this study suggest that the venom of the O. temporalis is highly neurotoxic in vitro and may contain procoagulant toxins, making this snake potentially dangerous to humans.

  8. Assessment of treatment efficacy and sebosuppressive effect of fractional radiofrequency microneedle on acne vulgaris.

    Science.gov (United States)

    Lee, Kyung Real; Lee, Eo Gin; Lee, Hee Jung; Yoon, Moon Soo

    2013-12-01

    A minimally invasive fractional radiofrequency microneedle (FRM) device has been used in skin rejuvenation and acne scars, and a recent pilot study demonstrated the positive therapeutic effect on acne. We evaluated the efficacy of FRM device for acne vulgaris in Asians and conducted objective measurement to assess its effect on sebum production. Twenty Korean patients with acne vulgaris received a single full-face FRM treatment. Outcome assessments included standardized photography, physician's global assessment, patient's satisfaction scores, acne lesion count, and objective measurements of casual sebum level (CSL) and sebum excretion rate (SER). They were evaluated at baseline and 2, 4, 8 weeks after the treatment. After a single FRM treatment, the CSL and the SER showed 30-60% and 70-80% reduction, respectively, at week 2 (P acne severity and acne lesion count also revealed clinical improvement with maximum efficacy at week 2, but returned to the baseline in most patients by week 8. Patients' satisfaction scores (0-4) were above 2 on average, and adverse effects were minimal. This prospective study demonstrated the sebosuppressive effect from a single FRM treatment, but its therapeutic efficacy in acne requires further evaluation. © 2013 Wiley Periodicals, Inc.

  9. SILICON CARBIDE GRAIN BOUNDARY DISTRIBUTIONS, IRRADIATION CONDITIONS, AND SILVER RETENTION IN IRRADIATED AGR-1 TRISO FUEL PARTICLES

    Energy Technology Data Exchange (ETDEWEB)

    Lillo, T. M.; Rooyen, I. J.; Aguiar, J. A.

    2016-11-01

    Precession electron diffraction in the transmission electron microscope was used to map grain orientation and ultimately determine grain boundary misorientation angle distributions, relative fractions of grain boundary types (random high angle, low angle or coincident site lattice (CSL)-related boundaries) and the distributions of CSL-related grain boundaries in the SiC layer of irradiated TRISO-coated fuel particles. Two particles from the AGR-1 experiment exhibiting high Ag-110m retention (>80%) were compared to a particle exhibiting low Ag-110m retention (<19%). Irradiated particles with high Ag-110m retention exhibited a lower fraction of random, high angle grain boundaries compared to the low Ag-110m retention particle. An inverse relationship between the random, high angle grain boundary fraction and Ag-110m retention is found and is consistent with grain boundary percolation theory. Also, comparison of the grain boundary distributions with previously reported unirradiated grain boundary distributions, based on SEM-based EBSD for similarly fabricated particles, showed only small differences, i.e. a greater low angle grain boundary fraction in unirradiated SiC. It was, thus, concluded that SiC layers with grain boundary distributions susceptible to Ag-110m release were present prior to irradiation. Finally, irradiation parameters were found to have little effect on the association of fission product precipitates with specific grain boundary types.

  10. Individual Assessment of Brain Tissue Changes in MS and the Effect of Focal Lesions on Short-Term Focal Atrophy Development in MS: A Voxel-Guided Morphometry Study

    Directory of Open Access Journals (Sweden)

    Jan Fox

    2016-04-01

    Full Text Available We performed voxel-guided morphometry (VGM investigating the mechanisms of brain atrophy in multiple sclerosis (MS related to focal lesions. VGM maps detect regional brain changes when comparing 2 time points on high resolution T1-weighted (T1w magnetic resonace imaging (MRI. Two T1w MR datasets from 92 relapsing-remitting MS patients obtained 12 months apart were analysed with VGM. New lesions and volume changes of focal MS lesions as well as in the surrounding tissue were identified by visual inspection on colour coded VGM maps. Lesions were dichotomized in active and inactive lesions. Active lesions, defined by either new lesions (NL (volume increase > 5% in VGM, chronic enlarging lesions (CEL (pre-existent T1w lesions with volume increase > 5%, or chronic shrinking lesions (CSL (pre-existent T1w lesions with volume reduction > 5% in VGM, were accompanied by tissue shrinkage in surrounding and/or functionally related regions. Volume loss within the corpus callosum was highly correlated with the number of lesions in its close proximity. Volume loss in the lateral geniculate nucleus was correlated with lesions along the optic radiation. VGM analysis provides strong evidence that all active lesion types (NL, CEL, and CSL contribute to brain volume reduction in the vicinity of lesions and/or in anatomically and functionally related areas of the brain.

  11. Correlation of the crystal orientation and electrical properties of silicon thin films on glass crystallized by line focus diode laser

    Energy Technology Data Exchange (ETDEWEB)

    Yun, J., E-mail: j.yun@unsw.edu.au [School of Photovoltaic and Renewable Energy Engineering, University of New South Wales, Sydney, NSW 2052 (Australia); Huang, J.; Teal, A. [School of Photovoltaic and Renewable Energy Engineering, University of New South Wales, Sydney, NSW 2052 (Australia); Kim, K. [School of Photovoltaic and Renewable Energy Engineering, University of New South Wales, Sydney, NSW 2052 (Australia); Suntech R& D Australia, Botany, NSW 2019 (Australia); Varlamov, S.; Green, M.A. [School of Photovoltaic and Renewable Energy Engineering, University of New South Wales, Sydney, NSW 2052 (Australia)

    2016-06-30

    In this work, crystallographic orientation of polycrystalline silicon films on glass formed by continuous wave diode laser crystallization was studied. Most of the grain boundaries were coincidence lattice Σ3 twin boundaries and other types of boundaries such as, Σ6, Σ9, and Σ21 were also frequently observed. The highest photoluminescence signal and mobility were observed for a grain with (100) orientation in the normal direction. X-ray diffraction results showed the highest occupancies between 41 and 70% along the (110) orientation. However, the highest occupancies changed to (100) orientation when a 100 nm thick SiO{sub x} capping layer was applied. Suns-Voc measurement and photoluminescence showed that higher solar cell performance is obtained from the cell crystallized with the capping layer, which is suspected from increased occupancies of (100) orientation. - Highlights: • Linear grains parallel to the scan direction formed with high density. • Σ3 coincidence lattice (CSL) boundaries found inside a grain • Grain boundaries exhibit various CSL boundaries such as Σ9, Σ18, and Σ27. • Grain with < 100 > orientation in normal direction showed highest electrical properties. • Improved voltage observed when percentage of < 100 > normal orientation is increased.

  12. Crystal interface and high-resolution electron microscopy—the best partner

    Directory of Open Access Journals (Sweden)

    H Ichinose

    2000-01-01

    Full Text Available Several contributions of HRTEM on the interface science are reviewed in chronological order. The first contribution of HRTEM is the observation of gold (113Σ°11 boundary, giving experimental proof of the CSL model. An observation of the asymmetric (112Σ°3 boundary follows. A SiC grain boundary is effectively assessed not by the density of CSL point but the number of dangling bonds in the boundary. A ZnO/Pd interface provides an example that a misfit dislocation does not necessarily accommodate the lattice mismatch. Segregated interface shows characteristic HRTEM image contrast, suggesting change in atomic bonding. An atomic height step in the semiconductor hetero interface is observed by the Chemical Lattice Image technique. In the diamond grain boundary a dangling bond may not elevate the boundary energy, being contradictory of the least dangling bond rule. Super-high resolution of the HVHRTEM enable us to determine atomic species in the grain boundary. Combined use of HRTEM and EELSE allows us to discuss the correlation between atomic structure and nature of the corresponding interface. It is not exaggeration to say that modern interface science does not exist witout HRTEM. On the other hand, many complicated interfaces found by HRTEM remained as unaswered questions. An innovative structural model is requested to appear on the scene.

  13. Key team physical and technical performance indicators indicative of team quality in the soccer Chinese super league.

    Science.gov (United States)

    Yang, Gai; Leicht, Anthony S; Lago, Carlos; Gómez, Miguel-Ángel

    2018-01-01

    The aim of this study was to identify the key physical and technical performance variables related to team quality in the Chinese Super League (CSL). Teams' performance variables were collected from 240 matches and analysed via analysis of variance between end-of-season-ranked groups and multinomial logistic regression. Significant physical performance differences between groups were identified for sprinting (top-ranked group vs. upper-middle-ranked group) and total distance covered without possession (upper and upper-middle-ranked groups and lower-ranked group). For technical performance, teams in the top-ranked group exhibited a significantly greater amount of possession in opponent's half, number of entry passes in the final 1/3 of the field and the Penalty Area, and 50-50 challenges than lower-ranked teams. Finally, time of possession increased the probability of a win compared with a draw. The current study identified key performance indicators that differentiated end-season team quality within the CSL.

  14. d-Cysteine Ligands Control Metal Geometries within De Novo Designed Three-Stranded Coiled Coils

    DEFF Research Database (Denmark)

    Ruckthong, Leela; Peacock, Anna F.A.; Pascoe, Cherilyn E.

    2017-01-01

    Although metal ion binding to naturally occurring l-amino acid proteins is well documented, understanding the impact of the opposite chirality (d-)amino acids on the structure and stereochemistry of metals is in its infancy. We examine the effect of a d-configuration cysteine within a designed l......-amino acid three-stranded coiled coil in order to enforce a precise coordination number on a metal center. The d chirality does not alter the native fold, but the side-chain re-orientation modifies the sterics of the metal binding pocket. l-Cys side chains within the coiled-coil structure have previously...... by comparison of the structure of ZnIICl(CSL16DC)3 2- to the published structure of ZnII(H2O)(GRAND-CSL12AL16LC)3 -. Moreover, spectroscopic analysis indicates that the CdII geometry observed by using l-Cys ligands (a mixture of three- and four-coordinate CdII) is altered to a single four-coordinate species...

  15. Implementation of a biotechnological process for vat dyeing with woad.

    Science.gov (United States)

    Osimani, Andrea; Aquilanti, Lucia; Baldini, Gessica; Silvestri, Gloria; Butta, Alessandro; Clementi, Francesca

    2012-09-01

    The traditional process for vat dyeing with woad (Isatis tinctoria L.) basically relies on microbial reduction of indigo to its soluble form, leucoindigo, through a complex fermentative process. In the 19th century, cultivation of woad went into decline and use of synthetic indigo dye and chemical reduction agents was established, with a consequent negative impact on the environment due to the release of polluting wastewaters by the synthetic dyeing industry. Recently, the ever-growing demand for environmentally friendly dyeing technologies has led to renewed interest in ecological textile traditions. In this context, this study aims at developing an environmentally friendly biotechnological process for vat dyeing with woad to replace use of polluting chemical reduction agents. Two simple broth media, containing yeast extract or corn steep liquor (CSL), were comparatively evaluated for their capacity to sustain the growth and reducing activity of the strain Clostridium isatidis DSM 15098(T). Subsequently, the dyeing capacity of the CSL medium added with 140 g L⁻¹ of woad powder, providing 2.4 g L⁻¹ of indigo dye, was evaluated after fermentation in laboratory bioreactors under anaerobic or microaerophilic conditions. In all fermentations, a sufficiently negative oxidation/reduction potential for reduction of indigo was reached as early as 24 h and maintained up to the end of the monitoring period. However, clearly faster indigo dye reduction was seen in the broth cultures fermented under strict anaerobiosis, thus suggesting the suitability of the N₂ flushing strategy for enhancement of bacterial-driven indigo reduction.

  16. Cesium-137 as a radiation source

    International Nuclear Information System (INIS)

    McMullen, W.H.; Sloan, D.P.

    1985-01-01

    The U.S. Department of Energy (DOE) Byproducts Utilization Program (BUP) seeks to develop and encourage widespread commercial use of defense byproducts that are produced by DOE. Cesium-l37 is one such byproduct that is radioactive and decays with emission of gamma rays. The beneficial use of this radiation to disinfect sewage sludge or disinfest food commodities is actively being pursued by the program. The radiation produced by cesium-l37(Cs-l37) is identical in form to that produced by cobalt-60(Co-60), an isotope that is widely used in commercial applications such as medical product sterilization. The choice of isotope to use depends on several factors ranging from inherent properties of the isotopes to availability and cost. The BUP, although centrally concerned with the beneficial use of Cs-l37, by investigating and assessing the feasibility of various uses hopes to define appropriate circumstances where cesium or cobalt might best be used to accomplish specific objectives. This paper discusses some of the factors that should be considered when evaluating potential uses for isotopic sources

  17. Coincidence orientations of grains in hexagonal materials

    International Nuclear Information System (INIS)

    Grimmer, H.; Warrington, D.H.

    1986-06-01

    The connection between the rotation matrix in hexagonal lattice coordinates and an angle-axis quadruple is given. The multiplication law of quadruples is derived. It corresponds to multiplying two matrices and gives the effect of two successive rotations. The relation is given between two quadruples that describe the same relative orientation of two lattices due to their hexagonal symmetry; a unique standard description of the relative orientation is proposed. The restrictions satisfied by rotations generating coincidence site lattices (CSLs) are derived for any value of the axial ratio rho = c/a. It is shown that the law for cubic lattices, where the multiplicity SIGMA of the CSL was equal to the least common denominator of the elements of the rotation matrix, does not always hold for hexagonal lattices. A generalisation of this law to lattices of arbitrary symmetry is given and another, quicker method to determine SIGMA for hexagonal lattices is derived. Finally, convenient algorithms are described for determining bases of the CSL and the DSC lattice. (author)

  18. Dietary Lactobacillus acidophilus positively influences growth performance, gut morphology, and gut microbiology in rurally reared chickens.

    Science.gov (United States)

    Forte, C; Manuali, E; Abbate, Y; Papa, P; Vieceli, L; Tentellini, M; Trabalza-Marinucci, M; Moscati, L

    2018-03-01

    In a market undergoing constant evolution, the production of chicken meat that consumers would perceive as "natural" and "animal friendly" is crucial. The use of probiotics in rurally reared chickens could represent a major opportunity to achieve mutual benefit for both the industry and consumers. A total of 264 male Kabir chicks were randomly distributed to one of 2 dietary treatments: the L group received a commercial feed supplemented with 2.0 g/100 kg of Lactobacillus acidophilus D2/CSL, while the C group received the same basal diet without the additive. To assess the effects of probiotic supplementation in the chickens' diet, productive performance was evaluated at d 21 and 42, whereas microbiological analyses of the intestinal content and intestinal histology and morphometry were performed at the end of the trial (d 42). At d 21 and 42, L birds showed better (P D2/CSL (CECT 4529) in rurally reared chicken breeds with positive effects on performance and gut health.

  19. Streptomyces misionensis PESB-25 Produces a Thermoacidophilic Endoglucanase Using Sugarcane Bagasse and Corn Steep Liquor as the Sole Organic Substrates

    Directory of Open Access Journals (Sweden)

    Marcella Novaes Franco-Cirigliano

    2013-01-01

    Full Text Available Streptomyces misionensis strain PESB-25 was screened and selected for its ability to secrete cellulases. Cells were grown in a liquid medium containing sugarcane bagasse (SCB as carbon source and corn steep liquor (CSL as nitrogen source, whose concentrations were optimized using response surface methodology (RSM. A peak of endoglucanase accumulation (1.01 U·mL−1 was observed in a medium with SCB 1.0% (w/v and CSL 1.2% (w/v within three days of cultivation. S. misionensis PESB-25 endoglucanase activity was thermoacidophilic with optimum pH and temperature range of 3.0 to 3.6 and 62° to 70°C, respectively. In these conditions, values of 1.54 U mL−1 of endoglucanase activity were observed. Moreover, Mn2+ was demonstrated to have a hyperactivating effect on the enzyme. In the presence of MnSO4 (8 mM, the enzyme activity increased threefold, up to 4.34 U·mL−1. Mn2+ also improved endoglucanase stability as the catalyst retained almost full activity upon incubation at 50°C for 4 h, while in the absence of Mn2+, enzyme activity decreased by 50% in this same period. Three protein bands with endoglucanase activity and apparent molecular masses of 12, 48.5 and 119.5 kDa were detected by zymogram.

  20. Comparing three experiential learning methods and their effect on medical students' attitudes to learning communication skills.

    Science.gov (United States)

    Koponen, Jonna; Pyörälä, Eeva; Isotalus, Pekka

    2012-01-01

    Despite numerous studies exploring medical students' attitudes to communication skills learning (CSL), there are apparently no studies comparing different experiential learning methods and their influence on students' attitudes. We compared medical students' attitudes to learning communication skills before and after a communication course in the data as a whole, by gender and when divided into three groups using different methods. Second-year medical students (n = 129) were randomly assigned to three groups. In group A (n = 42) the theatre in education method, in group B (n = 44) simulated patients and in group C (n = 43) role-play were used. The data were gathered before and after the course using Communication Skills Attitude Scale. Students' positive attitudes to learning communication skills (PAS; positive attitude scale) increased significantly and their negative attitudes (NAS; negative attitude scale) decreased significantly between the beginning and end of the course. Female students had more positive attitudes than the male students. There were no significant differences in the three groups in the mean scores for PAS or NAS measured before or after the course. The use of experiential methods and integrating communication skills training with visits to health centres may help medical students to appreciate the importance of CSL.

  1. Effects of post-harvest treatment using chitosan from Mucor circinelloides on fungal pathogenicity and quality of table grapes during storage.

    Science.gov (United States)

    de Oliveira, Carlos Eduardo Vasconcelos; Magnani, Marciane; de Sales, Camila Veríssimo; Pontes, Alline Lima de Souza; Campos-Takaki, Galba Maria; Stamford, Thayza Christina Montenegro; de Souza, Evandro Leite

    2014-12-01

    The aim of this study was to extract chitosan (CHI) from Mucor circinelloides UCP 050 grown in a corn steep liquor (CSL)-based medium under optimized conditions and to assess the efficacy of the obtained CHI to inhibit the post-harvest pathogenic fungi Aspergillus niger URM 5162 and Rhizopus stolonifer URM 3482 in laboratory media and as a coating on table grapes (Vitis labrusca L.). The effect of CHI coating on some physical, physicochemical and sensory characteristics of the fruits during storage was assessed. The greatest amount of CHI was extracted from M. circinelloides UCP 050 grown in medium containing 7 g of CSL per 100 mL at pH 5.5 with rotation at 180 rpm. CHI from M. circinelloides UCP 050 caused morphological changes in the spores of the fungal strains tested and inhibited mycelial growth and spore germination. CHI coating delayed the growth of the assayed fungal strains in artificially infected grapes, as well as autochthonous mycoflora during storage. CHI coating preserved the quality of grapes during storage, as measured by their physical, physicochemical and sensory attributes. These results demonstrate that edible coatings derived from M. circinelloides CHI could be a useful alternative for controlling pathogenic fungi and maintaining the post-harvest quality of table grapes. Copyright © 2014 Elsevier Ltd. All rights reserved.

  2. Vector magnetometer based on synchronous manipulation of nitrogen-vacancy centers in all crystal directions

    Science.gov (United States)

    Zhang, Chen; Yuan, Heng; Zhang, Ning; Xu, Lixia; Zhang, Jixing; Li, Bo; Fang, Jiancheng

    2018-04-01

    Negatively charged nitrogen vacancy (NV‑) centers in diamond have been extensively studied as high-sensitivity magnetometers, showcasing a wide range of applications. This study experimentally demonstrates a vector magnetometry scheme based on synchronous manipulation of NV‑ center ensembles in all crystal directions using double frequency microwaves (MWs) and multi-coupled-strip-lines (mCSL) waveguide. The application of the mCSL waveguide ensures a high degree of synchrony (99%) for manipulating NV‑ centers in multiple orientations in a large volume. Manipulation with double frequency MWs makes NV‑ centers of all four crystal directions involved, and additionally leads to an enhancement of the manipulation field. In this work, by monitoring the changes in the slope of the resonance line consisting of multi-axes NV‑ centers, measurement of the direction of the external field vector was demonstrated with a sensitivity of {{10}\\prime}/\\sqrt{Hz} . Based on the scheme, the fluorescence signal contrast was improved by four times higher and the sensitivity to the magnetic field strength was improved by two times. The method provides a more practical way of achieving vector sensors based on NV‑ center ensembles in diamond.

  3. Production of chlorothalonil hydrolytic dehalogenase from agro-industrial wastewater and its application in raw food cleaning.

    Science.gov (United States)

    He, Qin; Xu, Xi-Hui; Zhang, Fan; Tai, Yu-Kai; Luo, Yan-Fei; He, Jian; Hong, Qing; Jiang, Jian-Dong; Yan, Xin

    2017-06-01

    To reduce the fermentation cost for industrialization of chlorothalonil hydrolytic dehalogenase (Chd), agro-industrial wastewaters including molasses, corn steep liquor (CSL) and fermentation wastewater were used to substitute for expensive carbon and nitrogen sources and fresh water for lab preparation. The results showed that molasses and CSL could replace 5% carbon source and 100% organic nitrogen source respectively to maintain the same fermentation level. Re-fermentation from raffinate of ultra-filtered fermentation wastewater could achieve 61.03% of initial Chd activity and reach 96.39% activity when cultured in a mixture of raffinate and 50% of original medium constituent. Typical raw foods were chosen to evaluate the chlorothalonil removal ability of Chd. After Chd treatment for 2 h at room temperature, 97.40 and 75.55% of 30 mg kg -1 chlorothalonil on cherry tomato and strawberry respectively and 60.29% of 50 mg kg -1 chlorothalonil on Chinese cabbage were removed. Furthermore, the residual activity of the enzyme remained at 78-82% after treatment, suggesting its potential for reuse. This study proved the cost-feasibility of large-scale production of Chd from agro-industrial wastewater and demonstrated the potential of Chd in raw food cleaning. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry.

  4. [Effects of combined application of culture supernatant of human umbilical cord mesenchymal stem cells and ciprofloxacin on Staphylococcus aureus in vitro].

    Science.gov (United States)

    Zhou, B; Tu, H L; Ba, T; Wang, L F; Wang, S J; Nie, S Y

    2017-06-20

    Objective: To explore the effects of combined application of culture supernatant of human umbilical cord mesenchymal stem cells (hUCMSCs) and ciprofloxacin on Staphylococcus aureus (SA) in vitro. Methods: hUCMSCs were isolated from umbilical cord tissue of full-term healthy fetus after cesarean section and cultured. Cells in the third passage were used in the experiments after identification. SA strains isolated from wounds of burn patients in our burn wards were used in the experiments. Cells were divided into 0, 10, 100, and 1 000 ng/mL lipopolysaccharide (LPS) groups according to the random number table (the same dividing method below). Cells were cultured with culture medium of mesenchymal stem cells (MSCs) after being treated with medium containing the corresponding mass concentrations of LPS for 12 h. At post culture hour (PCH) 6, 12, and 24, 6 wells of culture supernatant of cells in each group were obtained to measure the content of LL-37 with enzyme-linked immunosorbent assay. Ninety blood agar plates were divided into ciprofloxacin control group (CC), ciprofloxacin+ supernatant group (CS), and ciprofloxacin+ supernatant+ LL-37 antibody group (CSL), with 30 blood agar plates in each group. Blood agar plates in group CC were coated with 1.5×10(8) colony forming unit (CFU)/mL bacteria solution prepared with normal saline. Blood agar plates in group CS were coated with 1.5×10(8) CFU/mL bacteria solution prepared with normal saline and culture supernatant of hUCMSCs (cultured by culture medium of MSCs, the same below) in double volume of normal saline. Blood agar plates in group CSL were coated with 1.5×10(8) CFU/mL bacteria solution prepared with normal saline, culture supernatant of hUCMSCs in double volume of normal saline, and 2.6 μL LL-37 antibody in the concentration of 2 μg/mL. At PCH 12, 24, and 48, 10 blood agar plates of each group were harvested to observe the distribution of SA colony on blood agar plate and to measure the diameter of

  5. Use of Hot Rolling for Generating Low Deviation Twins and a Disconnected Random Boundary Network in Inconel 600 Alloy

    Science.gov (United States)

    Sahu, Sandeep; Yadav, Prabhat Chand; Shekhar, Shashank

    2018-02-01

    In this investigation, Inconel 600 alloy was thermomechanically processed to different strains via hot rolling followed by a short-time annealing treatment to determine an appropriate thermomechanical process to achieve a high fraction of low-Σ CSL boundaries. Experimental results demonstrate that a certain level of deformation is necessary to obtain effective "grain boundary engineering"; i.e., the deformation must be sufficiently high to provide the required driving force for postdeformation static recrystallization, yet it should be low enough to retain a large fraction of original twin boundaries. Samples processed in such a fashion exhibited 77 pct length fraction of low-Σ CSL boundaries, a dominant fraction of which was from Σ3 ( 64 pct), the latter with very low deviation from its theoretical misorientation. The application of hot rolling also resulted in a very low fraction of Σ1 ( 1 pct) boundaries, as desired. The process also leads to so-called "triple junction engineering" with the generation of special triple junctions, which are very effective in disrupting the connectivity of the random grain boundary network.

  6. (1,3;1,4)-β-Glucan Biosynthesis by the CSLF6 Enzyme: Position and Flexibility of Catalytic Residues Influence Product Fine Structure.

    Science.gov (United States)

    Dimitroff, George; Little, Alan; Lahnstein, Jelle; Schwerdt, Julian G; Srivastava, Vaibhav; Bulone, Vincent; Burton, Rachel A; Fincher, Geoffrey B

    2016-04-05

    Cellulose synthase-like F6 (CslF6) genes encode polysaccharide synthases responsible for (1,3;1,4)-β-glucan biosynthesis in cereal grains. However, it is not clear how both (1,3)- and (1,4)-linkages are incorporated into a single polysaccharide chain and how the frequency and arrangement of the two linkage types that define the fine structure of the polysaccharide are controlled. Through transient expression in Nicotiana benthamiana leaves, two CSLF6 orthologs from different cereal species were shown to mediate the synthesis of (1,3;1,4)-β-glucans with very different fine structures. Chimeric cDNA constructs with interchanged sections of the barley and sorghum CslF6 genes were developed to identify regions of the synthase enzyme responsible for these differences. A single amino acid residue upstream of the TED motif in the catalytic region was shown to dramatically change the fine structure of the polysaccharide produced. The structural basis of this effect can be rationalized by reference to a homology model of the enzyme and appears to be related to the position and flexibility of the TED motif in the active site of the enzyme. The region and amino acid residue identified provide opportunities to manipulate the solubility of (1,3;1,4)-β-glucan in grains and vegetative tissues of the grasses and, in particular, to enhance the solubility of dietary fibers that are beneficial to human health.

  7. Cicatriz radial/lesão esclerosante complexa: aspectos radiológicos com correlação clínica, ultra-sonográfica e anatomopatológica Radial scar/complex sclerosing lesion: radiologic features with clinical, ultrasonographic and pathologic correlation

    Directory of Open Access Journals (Sweden)

    Cristina Caetano Stefenon

    2003-03-01

    Full Text Available OBJETIVO: Estudar, retrospectivamente, as várias formas de apresentação da cicatriz radial/lesão esclerosante complexa (CR/LEC na mamografia, correlacionando-as com o exame clínico e os achados ultra-sonográficos. Os achados histopatológicos e a associação da CR/LEC com hiperplasia atípica e carcinoma são discutidos. MATERIAIS E MÉTODOS: Foi realizado estudo retrospectivo de 926 lesões impalpáveis em 901 pacientes submetidas a biópsia excisional após localização pré-cirúrgica, do arquivo do Centro de Diagnóstico por Imagem e do Hospital Santa Rita, Vitória, ES, no período de outubro de 1993 a dezembro de 2001, nas quais 57 pacientes tiveram diagnóstico histopatológico de CR/LEC. RESULTADOS: A idade variou de 31 a 84 anos (média de 49 anos. As lesões foram palpáveis em dez casos. Na mamografia, 48 casos se apresentaram como distorção arquitetural, e com a mesma freqüência o nódulo espiculado e a densidade assimétrica, quatro casos cada. As microcalcificações foram detectadas na mamografia em 14 casos e em 20 quando o espécime cirúrgico foi avaliado. A ultra-sonografia foi realizada em 51 casos, tendo expressão em 17 como área hipoecóica irregular com atenuação acústica posterior. Houve 42 casos de CR/LEC sem ou com proliferação típica, nove casos com proliferação epitelial atípica e seis casos com carcinoma infiltrativo associado. CONCLUSÃO: Não é possível fazer diagnóstico diferencial de CR/LEC com câncer pelos métodos de imagem e a biópsia excisional deve ser realizada.OBJECTIVE: To review the different types of radial scar/complex sclerosing lesion (RS/CSL seen on clinical, mammography, and ultrasound examinations. The histopathology findings and the association of RS/CSL with atypical hyperplasia and malignancy are discussed. MATERIALS AND METHODS: We performed a retrospective study of patients from the files of the "Centro de Diagnóstico por Imagem and Hospital Santa Rita" - Vit

  8. Bimolecular encounters and re-encounters (cage effect) of a spin-labeled analogue of cholestane in a series of n-alkanes: effect of anisotropic exchange integral.

    Science.gov (United States)

    Vandenberg, Andrew D; Bales, Barney L; Salikhov, K M; Peric, Miroslav

    2012-12-27

    Electron paramagnetic resonance (EPR) spectra of the nitroxide spin probe 3β-doxyl-5α-cholestane (CSL) are studied as functions of the molar concentration, c, and the temperature, T, in a series of n-alkanes. The results are compared with a similar study of a much smaller spin probe, perdeuterated 2,2,6,6-tetramethyl-4-oxopiperidine-1-oxyl (pDT). The Heisenberg spin exchange (HSE) rate constants, K(ex), of CSL are similar in hexane, octane, and decane and are about one-half of those for pDT in the same solvents. They are also about one-half of the Stokes-Einstein-Perrin prediction. This reduction in HSE efficiency is attributed to an effective steric factor, f(eff), which was evaluated by comparing the results with the Stokes-Einstein-Perrin prediction or with pDT, and it is equal to 0.49 ± 0.03, independent of temperature. The unpaired spin density in CSL is localized near one end of the long molecule, so the exchange integral, J, leading to HSE, is expected to be large in some collisions and small in others; thus, J is modeled by an ideal distribution of values of J = J(0) with probability f and J = 0 with probability (1 - f). Because of rotational and translation diffusion during contact and between re-encounters of the probe, the effective steric factor is predicted to be f(eff) = f(1/2). Estimating the fraction of the surface of CSL with rich spin density yields a theoretical estimate of f(eff) = 0.59 ± 0.08, in satisfactory agreement with experiment. HSE is well described by simple hydrodynamic theory, with only a small dependence on solvent-probe relative sizes at the same value of T/η, where η is the viscosity of the solvent. This result is probably due to a fortuitous interplay between long- and short-range effects that describe diffusion processes over relatively large distances. In contrast, dipole-dipole interactions (DD) as measured by the line broadening, B(dip), and the mean time between re-encounters within the cage, τ(RE), vary significantly

  9. The Conversion of a Peer Teaching Course in the Puncture of Peripheral Veins for Medical Students into an Interprofessional Course

    Directory of Open Access Journals (Sweden)

    Brem, Beate Gabriele

    2016-04-01

    Full Text Available Objective: There is a great interest on both a national and international level in promoting cooperation between different occupational groups within the healthcare professions through interprofessional education (IPE , , . Within this project, a peer teaching course on the puncture of peripheral veins was therefore converted from a course for medical students into an IPE learning unit. Students from different occupational groups were to learn within the context of this course, according to the definition from the World Health Organisation (WHO, with and from each other . Project description: This course constituted a small group class in the peer teaching format. The didactic principle was based on the idea that the students were to practice the respective practical skills in pairs and give each other reciprocal feedback. Together with the Department for Health at the Bern University of Applied Sciences (BUAS and the Bern Center of Higher Education of Nusing (BCHEN, the course, which was conducted by the Institute of Medical Education at the University of Bern (IME, was converted into a voluntary IPE pilot project. Students from all three institutions were represented in terms of participants as well as tutors. Results: The course was evaluated very positively by participants, peer tutors and the participating institutions. By means of an OSCE, it could be proven that the course content had been successfully imparted. On the basis of these results, it was determined that the course should be compulsory in the future for students at all three institutions. Discussion: The evaluation results show the successful conversion of the course into an IPE format within the context of the pilot project. The interactive format of the course created the prerequisite that the students from different professional groups learned with and from each other in actuality, and did not just study the same objectives at the same time as with multiprofessional learning

  10. Data management of clinical trials during an outbreak of Ebola virus disease.

    Science.gov (United States)

    Hossmann, Stefanie; Haynes, Alan G; Spoerri, Adrian; Diatta, Ibrahima Dina; Aboubacar, Barry; Egger, Matthias; Rintelen, Felix; Trelle, Sven

    2017-10-23

    Clinical trial data management (DM) conducted during outbreaks like that of Ebola virus disease (EVD) in West Africa, 2014-2016, has to adapt to specific, unique circumstances. CTU Bern was asked to set up a safe data capture/management system that could be launched within a few weeks and cover two different vaccine trials. This article describes some of the challenges we faced and our solutions during the two different trials. Setting up a DM system was split into four phases/tasks: (1) quick set-up of the (electronic) data capture system (EDC) and mobile infrastructure in Bern, (2) moving the EDC and infrastructure to Conakry, Guinea and implementation of a local data management centre (DMC), (3) running the DMC, and (4) data cleaning. The DMC had to meet the following criteria: (1) quick implementation, (2) efficient maintenance and handling of data, and (3) procedures to guarantee data quality. The EDC (REDCap) was setup as a local area network. In order to ensure high data quality, double data entry, and then review of inconsistencies and offline plausibility checks were implemented. From the start of CTU Bern's involvement to the productive EDC took 11 weeks. It was necessary to adapt processes for dealing with data continuously throughout the trial conduct phase. The data management team processed 171,794 case report form pages from a total of 14,203 participants in the period between March and December 2015. Data management is a key task supporting trial conduct. For trials in emergency situations, many of our approaches are suitable, but we also provide a list of aspects that might be done differently. Copyright © 2017. Published by Elsevier Ltd.

  11. Computer simulations of liquid crystals: Defects, deformations and dynamics

    Science.gov (United States)

    Billeter, Jeffrey Lee

    1999-11-01

    Computer simulations play an increasingly important role in investigating fundamental issues in the physics of liquid crystals. Presented here are the results of three projects which utilize the unique power of simulations to probe questions which neither theory nor experiment can adequately answer. Throughout, we use the (generalized) Gay-Berne model, a widely-used phenomenological potential which captures the essential features of the anisotropic mesogen shapes and interactions. First, we used a Molecular Dynamics simulation with 65536 Gay-Berne particles to study the behaviors of topological defects in a quench from the isotropic to the nematic phase. Twist disclination loops were the dominant defects, and we saw evidence for dynamical scaling. We observed the loops separating, combining and collapsing, and we also observed numerous non-singular type-1 lines which appeared to be intimately involved with many of the loop processes. Second, we used a Molecular Dynamics simulation of a sphere embedded in a system of 2048 Gay-Berne particles to study the effects of radial anchoring of the molecules at the sphere's surface. A saturn ring defect configuration was observed, and the ring caused a driven sphere (modelling the falling ball experiment) to experience an increased resistance as it moved through the nematic. Deviations from a linear relationship between the driving force and the terminal speed are attributed to distortions of the saturn ring which we observed. The existence of the saturn ring confirms theoretical predictions for small spheres. Finally, we constructed a model for wedge-shaped molecules and used a linear response approach in a Monte Carlo simulation to investigate the flexoelectric behavior of a system of 256 such wedges. Novel potential models as well as novel analytical and visualization techniques were developed for these projects. Once again, the emphasis throughout was to investigate questions which simulations alone can adequately answer.

  12. Visit of Her Royal Highness Princess Maha Chakri Sirindhorn, Thailand

    CERN Multimedia

    Patrice Loïez

    2000-01-01

    Her Royal Highness Princess Maha Chakri Sirindhorn of Thailand (left) visiting DELPHI with Spokesman, Tiziano Camporesi, and Prapol Assavavirulhakarn, Pattaratorn Chirapravati, Claude Détraz, CERN Director for Fixed Target andFuture Programmes and Richard Breedon, University of California. No. 05: Princess Maha Chakri Sirindhorn and Daniel Treille, former spokesman of Delphi. No. 31: in Delphi experiment. No. 35: H.E. Mr. Virasakdi Futrakul, Ambassador, Permanent Representative ofThailand, Geneva with H.E. Dr. Ronarong Nopakun, Ambassador of the Thai Embassy in Bern

  13. Buchbesprechungen

    OpenAIRE

    2006-01-01

    Doherty-Sneddon, G. (2005): Was will das Kind mir sagen? Die Körpersprache des Kindes verstehen lernen. Bern. Hopf, C. (2005): Frühe Bindungen und Sozialisation. Weinheim. Thun-Hohenstein, L. (Hg.) (2005): Übergänge. Wendepunkte und Zäsuren in der kindlichen Entwicklung. Göttingen. Westhoff, E. (2005): Geistige Behinderung (er-)leben. Eine Reise in fremde Welten. Norderstedt. Seiffge-Krenke, I. (Hg.) (2005): Aggressionsentwicklung zwischen Normalität und Pathologie. Göt...

  14. A Critical Analysis of Globalilzation in the Context of Africa Underdevelopment

    Directory of Open Access Journals (Sweden)

    Mohammed O. Lawal

    2013-07-01

    While globalization is considered as a pride to the West and Europe, Africa is still being regarded as localized. The paper goes filrther to address the imbalance and disparity that have existed bern.'een the developed and underdeveloped countries in the areas of electronic, commerce, Information Communication Technology (ICT among others. Also, the opportunities and challenges posed by globalization are critically focused. The paper identifies the Aji-ican problems of underdevelopment and proposes strategies by which these problems could be solved so that Africa would be able to 'catch up' in the globalization process.

  15. CFD Modeling in Development of Renewable Energy Applications

    OpenAIRE

    Maher A.R. Sadiq Al-Baghdadi

    2013-01-01

    Chapter 1: A Multi-fluid Model to Simulate Heat and Mass Transfer in a PEM Fuel Cell. Torsten Berning, Madeleine Odgaard, Søren K. Kær Chapter 2: CFD Modeling of a Planar Solid Oxide Fuel Cell (SOFC) for Clean Power Generation. Meng Ni Chapter 3: Hydrodynamics and Hydropower in the New Paradigm for a Sustainable Engineering. Helena M. Ramos, Petra A. López-Jiménez Chapter 4: Opportunities for CFD in Ejector Solar Cooling. M. Dennis Chapter 5: Three Dimensional Modelling of Flow Field Around a...

  16. Crew of Hubble Space Telescope servicing mission visits Europe

    Science.gov (United States)

    1994-01-01

    The Hubble Space telescope servicing mission in December (STS-61) was a great success and the fully refurbished orbiting telescope produced absolutely remarkable first results just two weeks ago. The 7-member crew who carried out the mission will soon be in Europe to share their experience with the Press, ESA space specialists and the European space community. Public conferences will also be held in Switzerland, the home country of ESA astronaut Claude Nicollier. The visit of the STS-61 crew is scheduled as follows: Friday 11 February, 1994 - ESA Paris, France Presentation and Press Conference Location: ESA, 8/10 Rue Mario Nikis, 75015 Paris time: 16:00 hrs - 17:30 hrs contact: ESA, Public Relations Office Tel. (+33) 1 42 73 71 55 Fax. (+33) 1 42 73 76 90 Monday 14 February, 1994 - British Aerospace, Bristol, United Kingdom Presentation and Press Conference Location: British Aerospace, FPC 333, Filton, Bristol BS12 7QW time: 10:00 hrs - 12:00 hrs contact: BAe, Public Relations Tel. (+44) 272 36 33 69 Tel. (+44) 272 36 33 68 Tuesday 15 February, 1994 - ESA/ESTEC, Noordwijk, the Netherlands Presentation and Press Conference Location: Noordwijk Space Expo, Keplerlaan 3, 2201 AZ Noordwijk, the Netherlands time: 09:30 hrs - 12:00 hrs contact: ESTEC Public Relations Office Tel. (+31) 1719 8 3006 Fax. (+31) 1719 17 400 Wednesday 16 February, 1944 - ESO, Garching - Munich, Germany Presentation and Press Conference Location: European Southern Observatory, Karl- Schwarzschild-Str. 2, 85748 Garching -Munich, Germany time: to be decided contact: ESO Information Service Tel. (+49) 89 32 006 276 Fax. (+49) 89 320 23 62 Thursday 17 February, 1994 - Bern, Switzerland a. Presentation and Press Conference Location: Hotel Bern, Zeughausgasse 9, 3001 Bern, Switzerland time: 09:30 hrs contact: Press & Information Service of the Federal Dept. for Education & Sciences Tel. (+41) 31 322 80 34 Fax. (+41) 31 312 30 15 b. Public conference Location: University of Bern, Institute of Physics

  17. Poverty measurement : a theoretical contribution and application to Portugal 2007

    OpenAIRE

    Nunes, Celso Luís Pereira

    2012-01-01

    Doutoramento em Economia. Neste trabalho apresenta-se uma história do pensamento económico na medição de pobreza - desde o que pode ser considerado o inicio da economia da pobreza ate a era de redescoberta da pobreza durante a década de 1960 - bern como uma revisão da literatura sobre as principais ferramentas de medição da pobreza apresentadas pela Ciência Económica. E ainda apresentado, no âmbito da abordagem multidimensional, uma proposta de um índice de medição de pob...

  18. The ORPHEUS dark matter experiment

    International Nuclear Information System (INIS)

    Abplanalp, M.; Konter, J.A.; Mango, S.; Perret-Gallix, D.; Kainer, K.U.; Knoop, K.M.

    1996-01-01

    A progress report of the ORPHEUS dark matter experiment in the Bern Underground Laboratory is presented. A description of the ORPHEUS detector and its sensitivity to WIMPs is given. The detector will consist of 1 to 2 kg Sn granules operating in a magnetic field of approximately 320 G and at a temperature of 50 mK. In the first phase, the detector will be read out by conventional pickup coils, followed by a second phase with SQUID loops. Preliminary results on background and radioactivity measurements are shown. (orig.)

  19. Influência da posição das sementes no fruto do cacaueiro sôbre a germinação e desenvolvimento das mudas Influence of seed location in the cocoa fruit on germination and seedling growth

    Directory of Open Access Journals (Sweden)

    Mário Cardoso

    1963-01-01

    Full Text Available Foram plantadas separadamente, para comparação, amostras de sementes oriundas da ponta, do centro e da base de frutos de cacaueiro. Não foram notadas diferenças, quer na germinação das sementes, quer no desenvolvimento das mudas, em duas variedades estudadas.Seed samples from the top, center, and bottom of the cocoa fruit (Theobroma leiocarpa Bern. were planted separately for comparison. No difference in germination of the seeds or growth of the seedlings for the three types of samples was noticed.

  20. The 2016 Frontiers in Medicinal Chemistry Conference in Bonn.

    Science.gov (United States)

    Müller, Christa E; Thimm, Dominik; Baringhaus, Karl-Heinz

    2017-01-05

    Pushing the frontiers of medicinal chemistry: Christa Müller, Dominik Thimm, and Karl-Heinz Baringhaus look back at the events of the 2016 Frontiers in Medicinal Chemistry (FiMC) Conference held in Bonn, Germany. The report highlights the themes & talks in the annual conference hosted by the Joint Division of Medicinal Chemistry of the German Pharmaceutical Society (DPhG) and German Chemical Society (GDCh). It is also an invitation to the 2017 conference in Bern, Switzerland this February 12-15. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. Laser Bioeffects Resulting from Non-Linear Interactions of Ultrashort Pulses with Biological Systems

    Science.gov (United States)

    2004-07-01

    pp. 73-76, 1990. 2. K. Kong, P. - - -l, B. J. T.rc.b. .nd E. Gratt., P.on it lifetime imaging of autofluorescence in cells during UVA and NIR...photostress", J. Micros. 183, pp. 197-204, 1996. 4. K. Konig, Y. Liu, G. J. Sonek, M. W. Berns, and B. J. Tromberg, " Autofluorescence spectroscopy of...of melanin", Photochem. Photobiol. 70, pp. 146-151, 1999. 10. R. D. Glickman, "Phototoxicity to the retina : Mechanisms of damage", International

  2. The Lazarus effect

    CERN Multimedia

    Laurent Guiraud

    1998-01-01

    Members of the RD39 collaboration stage a demonstration of the Lazarus effect in the CERN cryolab. At the LHC experiments, the front-line inner detectors - trackers - will be traversed by a mammoth thousand million million passing particles per square centimetre over the lifetimes of the experiments. After long exposure to passing particles, defects appear in the silicon and the signal is destroyed. A group of physicists at Bern University have found that at temperatures below 100 K, dead detectors apparently come back to life. They're calling their discovery the Lazarus effect after the Biblical character raised from the dead by Jesus after he had been entombed for four days.

  3. A Monte Carlo simulation study of associated liquid crystals

    Science.gov (United States)

    Berardi, R.; Fehervari, M.; Zannoni, C.

    We have performed a Monte Carlo simulation study of a system of ellipsoidal particles with donor-acceptor sites modelling complementary hydrogen-bonding groups in real molecules. We have considered elongated Gay-Berne particles with terminal interaction sites allowing particles to associate and form dimers. The changes in the phase transitions and in the molecular organization and the interplay between orientational ordering and dimer formation are discussed. Particle flip and dimer moves have been used to increase the convergency rate of the Monte Carlo (MC) Markov chain.

  4. Introduction: Information and Musings

    Science.gov (United States)

    Shifman, M.

    The following sections are included: * Victor Frenkel * Background * The Accused * Alexander Leipunsky * Alexander Weissberg * Holodomor * The beginning of the Great Purge * Other foreigners at UPTI * The Ruhemanns * Tisza * Lange * Weisselberg * A detective story * Stalin's order * Yuri Raniuk * Giovanna Fjelstad * Giovanna's story * First time in the USSR * Fisl's humor * Houtermans and Pomeranchuk * Choices to make * Closing gaps * Houtermans and the Communist Party of Germany * Houtermans and von Ardenne * Houtermans' trip to Russia in 1941 * Why Houtermans had to flee from Berlin in 1945 * Houtermans in Göttingen in the 1940's * Denazification * Moving to Bern * Yuri Golfand, the discoverer of supersymmetry * Bolotovsky's and Eskin's essays * Moisei Koretz * FIAN * Additional recommended literature * References

  5. Teatrimaailm / Mari Kolle, Katrin Talts

    Index Scriptorium Estoniae

    Kolle, Mari

    2005-01-01

    23. märtsil avatakse unikaalne interneti-projekt "Cultu.Ru!" ; Londoni Criterion Theatre'is etendub "Amajuba. Me tõuseme lendu nagu tuvid", mida esitavad Lõuna-Aafrika viis näitlejat, kes räägivad oma elust ; ITI on tänavu ülemaailmse teatripäeva pühendanud naistele, korraldades rahvusvahelise kübernäituse "Naised teatris", mis esitleb eri maade teatripraktikuid : naislavastajaid, näitekirjanikke ja näitlejannasid XX sajandi II poolel ; Pariisis tegutsevast Päikeseteatrist ning teatri asutajast ja juhist A. Mnouchkine'ist

  6. [Mythodrama--a group psychotherapy model for work with children and adolescents].

    Science.gov (United States)

    Guggenbühl, A

    1992-10-01

    This article discusses group psychotherapy as a possible crisis intervention technique for children and juveniles with behavioral problems at school or whose families are going through divorce, or as an intervention technique in trouble some school classes. The therapeutic group work at the Children and Juvenile Educational Counselling Centre in Bern, Switzerland, is described - "mythodrama" or the "tales, fiction and horror technique", a therapeutic approach which was developed during the last couple of years. The tale at the beginning of the article serves as an introduction and is followed by a description of the different phases of mythodrama. Finally, the main elements of this approach are summarized.

  7. Engineering Study for a Full Scale Demonstration of Steam Reforming Black Liquor Gasification at Georgia-Pacific's Mill in Big Island, Virginia; FINAL

    International Nuclear Information System (INIS)

    Robert De Carrera; Mike Ohl

    2002-01-01

    Georgia-Pacific Corporation performed an engineering study to determine the feasibility of installing a full-scale demonstration project of steam reforming black liquor chemical recovery at Georgia-Pacific's mill in Big Island, Virginia. The technology considered was the Pulse Enhanced Steam Reforming technology that was developed and patented by Manufacturing and Technology Conversion, International (MTCI) and is currently licensed to StoneChem, Inc., for use in North America. Pilot studies of steam reforming have been carried out on a 25-ton per day reformer at Inland Container's Ontario, California mill and on a 50-ton per day unit at Weyerhaeuser's New Bern, North Carolina mill

  8. Gauge amplitude identities by on-shell recursion relation in S-matrix program

    International Nuclear Information System (INIS)

    Feng Bo; Huang Rijun; Jia Yin

    2011-01-01

    Using only the Britto-Cachazo-Feng-Witten (BCFW) on-shell recursion relation we prove color-order reversed relation, U(1)-decoupling relation, Kleiss-Kuijf (KK) relation and Bern-Carrasco-Johansson (BCJ) relation for color-ordered gauge amplitude in the framework of S-matrix program without relying on Lagrangian description. Our derivation is the first pure field theory proof of the new discovered BCJ identity, which substantially reduces the color-ordered basis from (n-2)! to (n-3)!. Our proof gives also its physical interpretation as the mysterious bonus relation with 1/(z 2 ) behavior under suitable on-shell deformation for no adjacent pair.

  9. A common objective, a variety of paths

    International Nuclear Information System (INIS)

    2009-01-01

    High-level political, governmental and regulatory decision makers, as well as representatives of economic and social groups and implementing organisations met in Berne, Switzerland to present and to reflect on their collective experience towards meeting the challenge of implementing national disposal projects for placing radioactive waste in deep geological formations. This summary highlights the main lessons to be learnt and final recommendations to assist future developments in national radioactive waste management programmes seeking to meet both technical and social imperatives of modern society. (authors)

  10. Seasonal variations in heavy mineral placer sand from Kalbadevi Bay, Ratnagiri, Maharashtra

    Digital Repository Service at National Institute of Oceanography (India)

    Valsangkar, A.B.

    spaced at ~1.5 km apart (Fig. 1). More details are given in Valsangkar (2005). Beach samples were obtained by push cores from the different beach environment that included dune, berm, hide tide (HT), mid tide (MT) and low tide (LT) area. The samples...) decreased to 12 % during post-monsoon season. Increase of sand content with depth in bern environment is therefore considered related to deposition due to wave and current action. May, 2K4; BP-02 0 20 40 60 80 100 120 Dune Berm HT MT LT Sand % 0-5 5...

  11. DOPRINOS SJEDINJENIH AMERIČKIH DRŽAVA UNIFIKACIJI MEĐUNARODNOG TRANSPORTNOG PRAVA

    OpenAIRE

    Vuković, Ante; Bodul, Dejan

    2013-01-01

    U radu se pokušava odgovoriti na pitanje koliko su Sjedinjene Američke Države, kroz stoljetnu povijest međunarodnih konvencija iz transportnog prava (počevši od Konvencije o međunarodnom prijevozu robe željeznicom, Bern, 1890. – CIM) zaista doprinosile unifikaciji međunarodnog prijevoznog prava. Prvi međunarodni ugovor globalnog značenja koji je SAD ratificirao bila je Međunarodna konvencija za izjednačavanje nekih pravila o teretnici, 1924. (Haaška pravila, 1924.) o prijevozu tereta morem – ...

  12. Project Inner Brick - Colorful Plastic Bricks in Psychotherapy - An Introduction to Methodology

    Directory of Open Access Journals (Sweden)

    Neidert László

    2015-06-01

    Full Text Available PIB is a research project pertaining to the psychotherapeutic potential of Lego bricks. This is based on Lego Group’s own method called Lego Seriousplay and Eric Berne's transactional analysis as a theoretical background. If we see it from the Lego’s aspect, our plan is a training like LSP. It is only alike because of the special application. We made a lot of modifications according to the original methodology. In this document we would like to present details of our research we have been working on for almost two years. The characteristics of our methodology will be illustrated, too.

  13. Die Ukraine-Krise und kritische Fragen an die EU-Erweiterungspolitik

    OpenAIRE

    Lippert, Barbara

    2014-01-01

    Die Ukraine-Krise konfrontiert die EU mit kritischen Fragen zu ihrer Erweiterungs-politik. Muss sie nach der Osterweiterung 2004/07 und dem gerade erst begonnenen Einzug der Westbalkan-Staaten nun mit Osteuropa für die übernächste Erweiterungs-runde rechnen? Sollte sie sich gar alsbald politisch verpflichten, interessierte und beitrittsfähige osteuropäische Länder eines Tages aufzunehmen? Wie jetzt auch viel-fach von EU-Akteuren geäußert, wäre dies voreilig: Denn in der konfliktgeladenen und ...

  14. Report of the krypton club: availability of sup(81m)krypton in europe

    International Nuclear Information System (INIS)

    Clark, J.; Watson, I.

    1982-01-01

    An active group of producers of krypton 81m generators has been formed. They met in Liege 27th February 1981 to discuss the technical and logistics problems in making krypton 81m generators more widely available in Europe. A resume of that meeting was prepared and distributed at two major medicine meetings in 1981, Pisa and Berne, in an attempt to alert potential users to the current situation and encourage them to make contact with the production centre most favourably situated logistically. (Author)

  15. Advantages and limits to the fermentation of easily-degradable industrial and food wastes in sewage treatment works; Vorteile und Grenzen der Vergaerung von leicht abbaubaren Industrie- und Lebensmittelabfaellen in Abwasserreinigungsanlagen. Vergleich zu landwirtschaftlichen Anlagen - Schlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Bachmann, N.; Wellinger, A. [Nova Energie GmbH, Aadorf (Switzerland); Bachmann, N. [EREP SA, Aclens (Switzerland)

    2009-12-15

    This final report for the Swiss Federal Office of Energy (SFOE) takes a look at the advantages and limits that apply to the fermentation of industrial and food wastes in sewage treatment facilities in comparison to agricultural installations. For this ecological review, a material-flow analysis was made which permitted the nutrient loss to be quantified. The report presents data on the energy and carbon dioxide balances for the method and also looks at the method from an economical point of view. Co-fermentation in the wastewater treatment plant in Berne, Switzerland, and in agricultural plant are examined.

  16. Constant external fields in gauge theory and the spin 0, 1/2, 1 path integrals

    International Nuclear Information System (INIS)

    Reuter, M.; Schmidt, M.G.

    1996-10-01

    We investigate the usefulness of the ''string-inspired technique'' for gauge theory calculations in a constant external field background. Our approach is based on Strassler's worldline path integral approach to the Bern-Kosower formalism, and on the construction of worldline (super-) Green's functions incorporating external fields as well as internal propagators. The worldline path integral representation of the gluon loop is reexamined in detail. We calculate the two-loop effective actions induced for a constant external field by a scalar and spinor loop, and the corresponding one-loop effective action in the gluon loop case. (orig.)

  17. Gluons for (almost) nothing, gravitons for free

    Science.gov (United States)

    Carrasco, John Joseph M.

    2013-07-01

    In this talk I describe a new method for organizing Yang-Mills scattering amplitudes that allow the definition of an entire multi-loop scattering amplitude in terms of a small number of "master" graphs. A small amount of information is required from the theory, and constraints propagate this information to the full amplitude. When organized in such away corresponding gravitational amplitudes are trivially found. This talk is based on work[1- 4] done in collaboration with Zvi Bern, Lance Dixon, Henrik Johansson, and Radu Roiban, and follows closely the presentation given in ref. [5].

  18. Method for the appraisal and classification of the suitability for use of watercourses - Appendices; Methodik zur Bewertung und Klassierung der Nutzungseignung von Fliessgewaesserstrecken. Grundlagen fuer die raeumliche Prioritaetensetzung bei der Wasserkraftnutzung und dem Schutz von Gewaessern - Annex 2: Beruecksichtigung der Schutz- und Nutzungsinteressen bei der Wasserkraftnutzung (ohne Karten)

    Energy Technology Data Exchange (ETDEWEB)

    Wehse, H.

    2009-10-15

    These appendices to final report for the Swiss Federal Office of Energy (SFOE) that discusses the fundamentals for setting priorities for the use of hydropower and the protection of streams and rivers present a rich bibliography on the subject and a documentation on current projects. Also a comprehensive list of criteria and a selection of particularly relevant criteria is presented. Also, the 'Master-plan river ecology' for the Canton of Berne, Switzerland, is included. A further appendix discusses the methodology used for the definition of potential for improvement as far as river morphology is concerned.

  19. Kauno medicinos universiteto Histologijos ir embriologijos katedrai – 80 metų

    OpenAIRE

    Valančiūtė, Angelija; Baltrušaitis, Kęstutis Stanislovas; Vitkus, Albertas; Vitkus, Aleksandras

    2003-01-01

    The Department of Histology and Embryology at Kaunas University was established in 1923. Professor E. Landau was the very first to head the Department. He arrived in Kaunas from the University of Bern (Switzerland) and worked here from 1923 till 1932. At that time the staff of the Department had only four people: professor E. Landau, head of the Department, J. Bubėnaitė, senior assistant, D. Kesiūnaitė, assistant, and J. Masevičius, laboratory assistant. From 1934 till 1937 the Department was...

  20. Readmission after treatment of Grade 3 and 4 renal injuries at a Level I trauma center: Statewide assessment using the Comprehensive Hospital Abstract Reporting System.

    Science.gov (United States)

    Winters, Brian; Wessells, Hunter; Voelzke, Bryan B

    2016-03-01

    One criticism of the existing renal trauma research is the limited outpatient follow-up after index hospitalization. We assessed readmission rates following treatment for American Association for the Surgery of Trauma (AAST) Grade 3 and 4 renal injury using the Comprehensive Hospital Abstract Reporting System (CHARS). We evaluated all patients with AAST Grade 3 and 4 renal injuries admitted to Harborview Medical Center (HMC) between 1998 and 2010, the only Level 1 trauma center in Washington state. Grade 4 renal injuries were stratified by collecting system laceration (CSL) or segmental vascular injury. Data were abstracted from the CHARS database for readmissions to any Washington state hospital within 6 months of renal injury. Clinical variables, diagnoses, and procedures were queried based on DRG International Classification of Diseases-9th Rev. codes. A total of 477 Grade 3 and 159 Grade 4 renal injuries were initially treated at HMC. On admission, 111 patients required intervention: 75 (16%) of 477 Grade 3 and 36 (23%) of 159 Grade 4 injuries. Within 6 months of index hospitalization, 86 (18%) of 477 Grade 3 and 38 (24%) of 159 Grade 4 patients were readmitted to any Washington state hospital. Eighty percent of Grade 3 injuries and 66% of Grade 4 injuries returned to HMC compared with secondary hospitals (p = 0.08). At readmission, 19 (22%) of 86 Grade 3 and 16 (42%) of 38 Grade 4 injuries had a urologic diagnosis. Subsequent procedural intervention was required on readmission in 6 (7%) of 86 Grade 3 and 5 (13%) of 38 Grade 4 renal injuries (all CSL injuries). A subset of patients treated for Grade 3 and 4 renal trauma will be readmitted for further management. While urologic diagnoses and additional procedures may be low overall, readmission to outside hospitals may preclude accurate determination of renal trauma outcomes. Based on these data, patients with Grade 4 CSL injuries seem to be at the highest risk for readmission and to require a subsequent

  1. Evidence for an association between non-syndromic cleft lip with or without cleft palate and a gene located on the long arm of chromosome 4

    Energy Technology Data Exchange (ETDEWEB)

    Healey, S.C.; Chenevix-Trench, G. [Queensland Institute of Medical Research, Brisbane (Australia); Mitchell, L.E. [Saint Louis Univ., MO (United States)

    1994-09-01

    Evidence of linkage has been reported for non-syndromic cleft lip with or without cleft palate (CL{+-}P) and two markers (D4S175 and D4S192) in the region 4q25-4q31.3. The linkage evidence comes from a single Caucasian pedigree with multiple cases of CL{+-}P in five generations. High-density pedigrees are, however, atypical of CL{+-}P and linkage evidence obtained from such a family may not be relevant to the majority of CL{+-}P families. We have, therefore, examined the association of CL{+-}P with both D4S175 and D4S192 in 95 unrelated CL{+-}P patients and 161 unselected controls. There was no evidence for an association between D4S175 and CL{+-}P in these data. There was, however, a significant association between D4S192 and CL{+-}P ({chi}{sup 2}{sub 4}=15.5,P=0.006), and the genotypic distribution was significantly heterogeneous between CL{+-}P patients and controls (P=0.025). Comparison of each of the four most common alleles (i.e A87, A89, A91 and A95), to all other alleles combined, indicated that A87 was significantly less common (OR=0.56,95% C.I. 0.34-0.90), and A95 was significantly more common (OR=1.88,95% C.I. 1.03-3.43) among the CL{+-}P patients than the controls. Although of only borderline significance, A89 also appeared to be more common among patients than controls (OR=1.43,95% C.I. 0.99-2.60). Hence, it appears that genetic variation at a CL{+-}P susceptibility locus (CSL) linked to D4S192 may be associated with both increased and decreased risk of CL{+-}P. In combination, A89 and A95 are significantly more common in CL{+-}P patients than in controls (OR=1.80;95% C.I. 1.24-2.60) and account for a risk ratio of 1.08 in the first degree relatives of CL{+-}P patients. These results provide further evidence for the presence of a CSL in the region 4q25-4q31.1, and indicate that the putative CSL is located closer to D4S192 than to D4S175.

  2. Revisiting Notechis scutatus venom: on shotgun proteomics and neutralization by the "bivalent" Sea Snake Antivenom.

    Science.gov (United States)

    Tan, Choo Hock; Tan, Kae Yi; Tan, Nget Hong

    2016-07-20

    Recent advances in proteomics enable deep profiling of the compositional details of snake venoms for improved understanding on envenomation pathophysiology and immunological neutralization. In this study, the venom of Australian tiger snake (Notechis scutatus) was trypsin-digested in solution and subjected to nano-ESI-LCMS/MS. Applying a relative quantitative proteomic approach, the findings revealed a proteome comprising 42 toxin subtypes clustered into 12 protein families. Phospholipases A2 constitute the most abundant toxins (74.5% of total venom proteins) followed by Kunitz serine protease inhibitors (6.9%), snake venom serine proteases (5.9%), alpha-neurotoxins (5.6%) and several toxins of lower abundance. The proteome correlates with N. scutatus envenoming effects including pre-synaptic and post-synaptic neurotoxicity and consumptive coagulopathy. The venom is highly lethal in mice (intravenous median lethal dose=0.09μg/g). BioCSL Sea Snake Antivenom, raised against the venoms of beaked sea snake (Hydrophis schistosus) and N. scutatus (added for enhanced immunogenicity), neutralized the lethal effect of N. scutatus venom (potency=2.95mg/ml) much more effectively than the targeted H.schistosus venom (potency=0.48mg/ml). The combined venom immunogen may have improved the neutralization against phospholipases A2 which are abundant in both venoms, but not short-neurotoxins which are predominant only in H. schistosus venom. A shotgun proteomic approach adopted in this study revealed the compositional details of the venom of common tiger snake from Australia, Notechis scutatus. The proteomic findings provided additional information on the relative abundances of toxins and the detection of proteins of minor expression unreported previously. The potent lethal effect of the venom was neutralized by bioCSL Sea Snake Antivenom, an anticipated finding due to the fact that the Sea Snake Antivenom is actually bivalent in nature, being raised against a mix of venoms of the

  3. Etiology of chronic skin lesions in subjects with peripheral arterial disease.

    Science.gov (United States)

    Chisari, G; Chisari, E M; Borzì, A M; Grasso, A; Chisari, C G

    2018-01-01

    Skin lesions can be defined as lesions that result in loss of tissues and their joints, and often this cutaneous skin process is a primary or secondary consequence of the structural changes in the skin itself. Subjects with peripheral arteripathies that develop chronic skin lesions in the lower extremities of the Western world are constantly increasing. We conducted a study on the etiologic incidence of chronic skin lesions in peripheral arterial disease CSLpa subjects in the lower limbs compared to subjects with chronic skin lesions CSL (controls). 30 subjects with peripheral atheropathies PA (22 F - 8 M mean age 74,5 ± 4,9) and with chronic skin lesions (CSLpa) in the lower limbs "A" group were admitted to our study according to a randomized and compared to 30 no peripheral atheropathies subjects (19 F-11 M, mean age 81,5 ± 7,3 - controls) group B with chronic skin lesions (CSL). These two groups "A" and "B" have been studied and compared on the basis of infectious etiology responsible for the infectious skin process. In the subjects of the "A" group we found a 12 positive assay of 40.0% of the examinations, while in the group "B" we achieved a total cultured positivity of 9 cases corresponding to 30.0% of the examinations . For the number of bacterial species identified for "A" group we obtained 3 mono microbial and 6 poly microbial bacteriological tests and for group "B" we observed 7 mono microbial and 2 poly microbial tests. All bacteriological isolates showed "in vitro" sensitivity to satisfactory ciprofloxacin with MICs range of 0.78-1.56mg/L. The data observed after 4 weeks after the amniotic membrane (MA) in the two study groups A and B were respectively the following: and for group A 50% scarring, 46.6% partial resolution and in one case worsening for the B-healing group in 63.3%, the partial resolution in the remaining 36.6. The data from this study show a different etiology between subjects with CSLpa than subjects with CSL. This phenomenon confirms

  4. Production of Bacterial Cellulose by Gluconacetobacter hansenii Using Corn Steep Liquor As Nutrient Sources

    Directory of Open Access Journals (Sweden)

    Andrea F. S. Costa

    2017-10-01

    Full Text Available Cellulose is mainly produced by plants, although many bacteria, especially those belonging to the genus Gluconacetobacter, produce a very peculiar form of cellulose with mechanical and structural properties that can be exploited in numerous applications. However, the production cost of bacterial cellulose (BC is very high to the use of expensive culture media, poor yields, downstream processing, and operating costs. Thus, the purpose of this work was to evaluate the use of industrial residues as nutrients for the production of BC by Gluconacetobacter hansenii UCP1619. BC pellicles were synthesized using the Hestrin–Schramm (HS medium and alternative media formulated with different carbon (sugarcane molasses and acetylated glucose and nitrogen sources [yeast extract, peptone, and corn steep liquor (CSL]. A jeans laundry was also tested. None of the tested sources (beside CSL worked as carbon and nutrient substitute. The alternative medium formulated with 1.5% glucose and 2.5% CSL led to the highest yield in terms of dry and hydrated mass. The BC mass produced in the alternative culture medium corresponded to 73% of that achieved with the HS culture medium. The BC pellicles demonstrated a high concentration of microfibrils and nanofibrils forming a homogenous, compact, and three-dimensional structure. The biopolymer produced in the alternative medium had greater thermal stability, as degradation began at 240°C, while degradation of the biopolymer produced in the HS medium began at 195°C. Both biopolymers exhibited high crystallinity. The mechanical tensile test revealed the maximum breaking strength and the elongation of the break of hydrated and dry pellicles. The dry BC film supported up to 48 MPa of the breaking strength and exhibited greater than 96.98% stiffness in comparison with the hydrated film. The dry film supported up to 48 MPa of the breaking strength and exhibited greater than 96.98% stiffness in comparison with the hydrated film

  5. Precession electron diffraction for SiC grain boundary characterization in unirradiated TRISO fuel

    International Nuclear Information System (INIS)

    Lillo, T.M.; Rooyen, I.J. van; Wu, Y.Q.

    2016-01-01

    Highlights: • SiC grain orientation determined by TEM-based precession electron diffraction. • Orientation data improved with increasing TEM sample thickness. • Fraction of low angle grain boundaries lower from PED data than EBSD data. • Fractions of high angle and CSL-related boundaries similar to EBSD data. - Abstract: Precession electron diffraction (PED), a transmission electron microscopy-based technique, has been evaluated for the suitability for evaluating grain boundary character in the SiC layer of tristructural isotropic (TRISO) fuel. This work reports the effect of transmission electron microscope (TEM) lamella thickness on the quality of data and establishes a baseline comparison to SiC grain boundary characteristics, in an unirradiated TRISO particle, determined previously using a conventional electron backscatter diffraction (EBSD) scanning electron microscope (SEM)-based technique. In general, it was determined that the lamella thickness produced using the standard focused ion beam (FIB) fabrication process (∼80 nm), is sufficient to provide reliable PED measurements, although thicker lamellae (∼120 nm) were found to produce higher quality orientation data. Also, analysis of SiC grain boundary character from the TEM-based PED data showed a much lower fraction of low-angle grain boundaries compared to SEM-based EBSD data from the SiC layer of a TRISO-coated particle made using the same fabrication parameters and a SiC layer deposited at a slightly lower temperature from a surrogate TRISO particle. However, the fractions of high-angle and coincident site lattice (CSL)-related grain boundaries determined by PED are similar to those found using SEM-based EBSD. Since the grain size of the SiC layer of TRSIO fuel can be as small as 250 nm (Kirchhofer et al., 2013), depending on the fabrication parameters, and since grain boundary fission product precipitates in irradiated TRISO fuel can be nano-sized, the TEM-based PED orientation data

  6. Climatic trends and anomalies in Europe 1675-1715. High resolution spatio-temporal reconstructions from direct meteorological observations and proxy data: Methods and results

    International Nuclear Information System (INIS)

    Frenzel, B.; Pfister, C.; Glaeser, B.

    1994-01-01

    This volume contains the proceedings of a conference held at the University of Bern in Switzerland on 2-4 September 1992 by a group of historical geographers, historians, palaeobotanists and meteorologists originating from fifteen European nations as well as from China and Japan. It was the first international symposium of this kind for which the participants had previously submitted various kinds of palaeoclimatic data - early instrumental series, documentary data, dendroclimatic data - in a standardized form to a common data base in order to have this evidence ready to include in a pan-European multi-proxy mapping scheme at the time of the meeting. A team of meteorological experts worked on interpreting some of these data in terms of rough monthly synoptic weather situations in order to test the suitability of the evidence for this purpose. This volume includes both the regional contributions of the individual partners presented at the Bern workshop, as well as the two hundred monthly synoptic weather maps which resulted from the common effort of the group of meteorologists at the Copenhagen meeting. (orig.)

  7. Shear flow simulations of biaxial nematic liquid crystals

    Science.gov (United States)

    Sarman, Sten

    1997-08-01

    We have calculated the viscosities of a biaxial nematic liquid crystal phase of a variant of the Gay-Berne fluid [J. G. Gay and B. J. Berne, J. Chem. Phys. 74, 3316 (1981)] by performing molecular dynamics simulations. The equations of motion have been augmented by a director constraint torque that fixes the orientation of the directors. This makes it possible to fix them at different angles relative to the stream lines in shear flow simulations. In equilibrium simulations the constraints generate a new ensemble. One finds that the Green-Kubo relations for the viscosities become linear combinations of time correlation function integrals in this ensemble whereas they are complicated rational functions in the conventional canonical ensemble. We have evaluated these Green-Kubo relations for all the shear viscosities and all the twist viscosities. We have also calculated the alignment angles, which are functions of the viscosity coefficients. We find that there are three real alignment angles but a linear stability analysis shows that only one of them corresponds to a stable director orientation. The Green-Kubo results have been cross checked by nonequilibrium shear flow simulations. The results from the different methods agree very well. Finally, we have evaluated the Miesowicz viscosities [D. Baalss, Z. Naturforsch. Teil A 45, 7 (1990)]. They vary by more than 2 orders of magnitude. The viscosity is consequently highly orientation dependent.

  8. Predicting stability limits for pure and doped dicationic noble gas clusters undergoing coulomb explosion: A parallel tempering based study.

    Science.gov (United States)

    Ghorai, Sankar; Chaudhury, Pinaki

    2018-05-30

    We have used a replica exchange Monte-Carlo procedure, popularly known as Parallel Tempering, to study the problem of Coulomb explosion in homogeneous Ar and Xe dicationic clusters as well as mixed Ar-Xe dicationic clusters of varying sizes with different degrees of relative composition. All the clusters studied have two units of positive charges. The simulations reveal that in all the cases there is a cutoff size below which the clusters fragment. It is seen that for the case of pure Ar, the value is around 95 while that for Xe it is 55. For the mixed clusters with increasing Xe content, the cutoff limit for suppression of Coulomb explosion gradually decreases from 95 for a pure Ar to 55 for a pure Xe cluster. The hallmark of this study is this smooth progression. All the clusters are simulated using the reliable potential energy surface developed by Gay and Berne (Gay and Berne, Phys. Rev. Lett. 1982, 49, 194). For the hetero clusters, we have also discussed two different ways of charge distribution, that is one in which both positive charges are on two Xe atoms and the other where the two charges are at a Xe atom and at an Ar atom. The fragmentation patterns observed by us are such that single ionic ejections are the favored dissociating pattern. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  9. Exploration of Icy Moons in the Outer Solar System: Updated Planetary Protection Requirements for Missions to Enceladus and Europa

    Science.gov (United States)

    Rummel, J. D.; Race, M. S.

    2016-12-01

    Enceladus and Europa are bodies with icy/watery environments and potential habitable conditions for life, making both of great interest in astrobiological studies of chemical evolution and /or origin of life. They are also of significant planetary protection concern for spacecraft missions because of the potential for harmful contamination during exploration. At a 2015 COSPAR colloquium in Bern Switzerland, international scientists identified an urgent need to establish planetary protection requirements for missions proposing to return samples to Earth from Saturn's moon Enceladus. Deliberations at the meeting resulted in recommended policy updates for both forward and back contamination requirements for missions to Europa and Enceladus, including missions sampling plumes originating from those bodies. These recently recommended COSPAR policy revisions and biological contamination requirements will be applied to future missions to Europa and Encealadus, particularly noticeable in those with plans for in situ life detection and sample return capabilities. Included in the COSPAR policy are requirementsto `break the chain of contact' with Europa or Enceladus, to keep pristine returned materials contained, and to complete required biohazard analyses, testing and/or sterilization upon return to Earth. Subsequent to the Bern meeting, additional discussions of Planetary Protection of Outer Solar System bodies (PPOSS) are underway in a 3-year study coordinated by the European Science Foundation and involving multiple international partners, including Japan, China and Russia, along with a US observer. This presentation will provide science and policy updates for those whose research or activities will involve icy moon missions and exploration.

  10. Small hydropower plants in Switzerland: definition of spatial priorities, taking into account the conflicting interests of power production and protection of the environment

    International Nuclear Information System (INIS)

    Wehse, Heiko; Pazhepurackel, Vinitha

    2012-01-01

    Due to the promotion of small hydropower plants in Switzerland, a lot of new projects have been planned. This leads to conflicts of interests, especially between ecology and power production. Where should new power plants be built, and which rivers should be protected from any further impact ? In this paper a methodology is developed in order to find answers to those questions. It confronts the oppositional interests for the use and protection of rivers in a transparent way. By doing so, it is hoped to rationalize conflicts. The methodology should help the authorities to evaluate new projects, and it is a basis for regional strategies of river use and protection. The method was tested in collaboration with the cantonal authority of Bern to classify all the rivers of the canton (12'000 km) [Conseil-executif du canton de Berne 2009]. For each river section, the different interests were identified. It has been adapted for the canton of Fribourg to classify the river reaches where new plants are planned [Wehse 2010]. In 2011 the swiss confederation has published a recommendation for the cantonal and communal authorities, concerning the elaboration of cantonal strategies for the use and protection of the rivers [Wehse 2011], which is based on the same method. (authors)

  11. Mobile platform for fish migration upstream from the discharge sill situated near Dacia bridge on Crișul Repede River

    Directory of Open Access Journals (Sweden)

    Răzvan VOICU

    2016-06-01

    Full Text Available Longitudinal connectivity represent the way in which organisms move the energy and material exchanges located throughout the water. Fragmentation the longitudinal connectivity of watercourses caused by dams or other hydrotechnical constructions represent a major impact on sediment transport, hydrological regime, downstream moving and biota migration. The hydromorphological elements (river continuity, as well as chemical, biological, physicochemical elements characterize the ecological status of rivers. Migratory fish species: nase (Chondrostoma nasus - protected by Bern Convention - Appendix III, barbel (Barbus barbus - rare species, protected Habitats Directive (Annex V, annex 4A of Low nr.462 and Red List of RBDD and Freshwater bream (Abramis brama - protected by Bern Convention (Appendix III are blocked by the hydrotechnical constructions (discharge sills, dams located across the watercourse Crișul Repede River. One of the important think of this system is the gravitational fall of water. This solution will lead to the restoration of the longitudinal connection of the Crișul Repede River in the Oradea City, near Dacia Bridge. Romania is part of the European Union and it has the obligation to implement the provisions of the Water Framework Directive 2000/60/EC, transposed into Romanian legislation by the Water Law 107/1996 as supplemented and amended (Act 310/2004.

  12. Traumatization and chronic pain: a further model of interaction

    Directory of Open Access Journals (Sweden)

    Egloff N

    2013-11-01

    Full Text Available Niklaus Egloff,1 Anna Hirschi,2 Roland von Känel1 1Department of General Internal Medicine, Division of Psychosomatic Medicine, Inselspital, University Hospital, Bern, Switzerland; 2Outpatient Clinic for Victims of Torture and War, Swiss Red Cross, Bern-Wabern, Switzerland Abstract: Up to 80% of patients with severe posttraumatic stress disorder are suffering from “unexplained” chronic pain. Theories about the links between traumatization and chronic pain have become the subject of increased interest over the last several years. We will give a short summary about the existing interaction models that emphasize particularly psychological and behavioral aspects of this interaction. After a synopsis of the most important psychoneurobiological mechanisms of pain in the context of traumatization, we introduce the hypermnesia–hyperarousal model, which focuses on two psychoneurobiological aspects of the physiology of learning. This hypothesis provides an answer to the hitherto open question about the origin of pain persistence and pain sensitization following a traumatic event and also provides a straightforward explanatory model for educational purposes. Keywords: posttraumatic stress disorder, chronic pain, hypermnesia, hypersensitivity, traumatization

  13. Coarse-grained electrostatic interactions of coronene: Towards the crystalline phase

    Energy Technology Data Exchange (ETDEWEB)

    Heinemann, Thomas, E-mail: thomas.heinemann@tu-berlin.de; Klapp, Sabine H. L., E-mail: klapp@physik.tu-berlin.de [Institut für Theoretische Physik, Technische Universität Berlin, Hardenbergstr. 36, 10623 Berlin (Germany); Palczynski, Karol, E-mail: karol.palczynski@helmholtz-berlin.de; Dzubiella, Joachim, E-mail: joachim.dzubiella@helmholtz-berlin.de [Institut für Physik, Humboldt Universität zu Berlin, Newtonstraße 15, 12489 Berlin (Germany); Institut für Weiche Materie und Funktionale Materialen, Helmholtz-Zentrum Berlin für Materialien und Energie, Hahn-Meitner Platz 1, 14109 Berlin (Germany)

    2015-11-07

    In this article, we present and compare two different, coarse-grained approaches to model electrostatic interactions of disc-shaped aromatic molecules, specifically coronene. Our study builds on our previous work [T. Heinemann et al., J. Chem. Phys. 141, 214110 (2014)], where we proposed, based on a systematic coarse-graining procedure starting from the atomistic level, an anisotropic effective (Gay-Berne-like) potential capable of describing van der Waals contributions to the interaction energy. To take into account electrostatics, we introduce, first, a linear quadrupole moment along the symmetry axis of the coronene disc. The second approach takes into account the fact that the partial charges within the molecules are distributed in a ring-like fashion. We then reparametrize the effective Gay-Berne-like potential such that it matches, at short distances, the ring-ring potential. To investigate the validity of these two approaches, we perform many-particle molecular dynamics simulations, focusing on the crystalline phase (karpatite) where electrostatic interaction effects are expected to be particularly relevant for the formation of tilted stacked columns. Specifically, we investigate various structural parameters as well as the melting transition. We find that the second approach yields consistent results with those from experiments despite the fact that the underlying potential decays with the wrong distance dependence at large molecule separations. Our strategy can be transferred to a broader class of molecules, such as benzene or hexabenzocoronene.

  14. Effects of molecular elongation on liquid crystalline phase behaviour: isotropic-nematic transition

    Science.gov (United States)

    Singh, Ram Chandra; Ram, Jokhan

    2003-08-01

    We present the density-functional approach to study the isotropic-nematic transitions and calculate the values of freezing parameters of the Gay-Berne liquid crystal model, concentrating on the effects of varying the molecular elongation, x0. For this, we have solved the Percus-Yevick integral equation theory to calculate the pair-correlation functions of a fluid the molecules of which interact via a Gay-Berne pair potential. These results have been used in the density-functional theory as an input to locate the isotropic-nematic transition and calculate freezing parameters for a range of length-to-width parameters 3.0⩽ x0⩽4.0 at reduced temperatures 0.95 and 1.25. We observed that as x0 is increased, the isotropic-nematic transition is seen to move to lower density at a given temperature. We find that the density-functional theory is good to study the freezing transitions in such fluids. We have also compared our results with computer simulation results wherever they are available.

  15. Influenza Pandemics and Tuberculosis Mortality in 1889 and 1918: Analysis of Historical Data from Switzerland.

    Science.gov (United States)

    Zürcher, Kathrin; Zwahlen, Marcel; Ballif, Marie; Rieder, Hans L; Egger, Matthias; Fenner, Lukas

    2016-01-01

    Tuberculosis (TB) mortality declined in the northern hemisphere over the last 200 years, but peaked during the Russian (1889) and the Spanish (1918) influenza pandemics. We studied the impact of these two pandemics on TB mortality. We retrieved historic data from mortality registers for the city of Bern and countrywide for Switzerland. We used Poisson regression models to quantify the excess pulmonary TB (PTB) mortality attributable to influenza. Yearly PTB mortality rates increased during both influenza pandemics. Monthly influenza and PTB mortality rates peaked during winter and early spring. In Bern, for an increase of 100 influenza deaths (per 100,000 population) monthly PTB mortality rates increased by a factor of 1.5 (95%Cl 1.4-1.6, ppandemic. Nationally, the factor was 2.0 (95%Cl 1.8-2.2, ppandemics. We demonstrate excess PTB mortality during historic influenza pandemics in Switzerland, which supports a role for influenza vaccination in PTB patients in high TB incidence countries.

  16. Coarse-grained electrostatic interactions of coronene: Towards the crystalline phase

    International Nuclear Information System (INIS)

    Heinemann, Thomas; Klapp, Sabine H. L.; Palczynski, Karol; Dzubiella, Joachim

    2015-01-01

    In this article, we present and compare two different, coarse-grained approaches to model electrostatic interactions of disc-shaped aromatic molecules, specifically coronene. Our study builds on our previous work [T. Heinemann et al., J. Chem. Phys. 141, 214110 (2014)], where we proposed, based on a systematic coarse-graining procedure starting from the atomistic level, an anisotropic effective (Gay-Berne-like) potential capable of describing van der Waals contributions to the interaction energy. To take into account electrostatics, we introduce, first, a linear quadrupole moment along the symmetry axis of the coronene disc. The second approach takes into account the fact that the partial charges within the molecules are distributed in a ring-like fashion. We then reparametrize the effective Gay-Berne-like potential such that it matches, at short distances, the ring-ring potential. To investigate the validity of these two approaches, we perform many-particle molecular dynamics simulations, focusing on the crystalline phase (karpatite) where electrostatic interaction effects are expected to be particularly relevant for the formation of tilted stacked columns. Specifically, we investigate various structural parameters as well as the melting transition. We find that the second approach yields consistent results with those from experiments despite the fact that the underlying potential decays with the wrong distance dependence at large molecule separations. Our strategy can be transferred to a broader class of molecules, such as benzene or hexabenzocoronene

  17. Comment to: The effects of an 8-week multicomponent inpatient treatment program on body composition and anaerobic fitness in overweight and obese children and adolescents

    Directory of Open Access Journals (Sweden)

    Radtke T

    2014-03-01

    Full Text Available Thomas Radtke,1 Bruno H Knöpfli,2 Johannes H Wildhaber,3 Jürg Hammer4 1Division of Cardiovascular Prevention, Rehabilitation and Sports Medicine, Swiss Cardiovascular Center, Inselspital, University Hospital and University of Bern, Bern, 2Kinder und Jugendmedizin, Zurich, 3Department of Pediatrics, Hospital Fribourg, Fribourg, 4Division of Intensive Care and Pulmonology, University Children's Hospital Basel, Basel, SwitzerlandWe note with surprise a recent paper entitled "The effects of an 8-week multicomponent inpatient treatment program on body composition and anaerobic fitness in overweight and obese children and adolescents" by Karner-Rezek et al1 published in the International Journal of General Medicine concerning the effects of an 8-week multicomponent inpatient treatment program on body composition and anaerobic fitness in overweight and obese children and adolescents. We would like to take this opportunity to comment on the study findings and, in particular, address the methodological inconsistencies and ambiguities in this study.View original paper by Karner-Rezek and colleagues.

  18. National implementation of the UNECE convention on long-range transboundary air pollution (effects). Pt. 2. Impacts and risk estimation, critical loads, biodiversity, dynamic modelling, critical level violation, material corrosion; Nationale Umsetzung UNECE-Luftreinhaltekonvention (Wirkungen). T. 2. Wirkungen und Risikoabschaetzungen Critical Loads, Biodiversitaet, Dynamische Modellierung, Critical Levels Ueberschreitungen, Materialkorrosion

    Energy Technology Data Exchange (ETDEWEB)

    Gauger, Thomas [Bundesforschungsanstalt fuer Landwirtschaft, Braunschweig (DE). Inst. fuer Agraroekologie (FAL-AOE); Stuttgart Univ. (Germany). Inst. fuer Navigation; Haenel, Hans-Dieter; Roesemann, Claus [Bundesforschungsanstalt fuer Landwirtschaft, Braunschweig (DE). Inst. fuer Agraroekologie (FAL-AOE); Nagel, Hans-Dieter; Becker, Rolf; Kraft, Philipp; Schlutow, Angela; Schuetze, Gudrun; Weigelt-Kirchner, Regine [OeKO-DATA Gesellschaft fuer Oekosystemanalyse und Umweltdatenmanagement mbH, Strausberg (Germany); Anshelm, Frank [Geotechnik Suedwest Frey Marx GbR, Bietigheim-Bissingen (Germany)

    2008-09-15

    The report on the implementation of the UNECE convention on long-range transboundary air pollution Pt.2 covers the following issues: The tasks of the NFC (National Focal Center) Germany including the ICP (international cooperative program) modeling and mapping and the expert panel for heavy metals. Results of the work for the multi-component protocol cover the initial data for the calculation of the critical loads following the mass balance method, critical loads for acid deposition, critical loads for nitrogen input, critical load violations (sulfur, nitrogen). The results of work for the heavy metal protocol cover methodology development and recommendations for ICO modeling and mapping in accordance with international development, contributions of the expert group/ task force on heavy metals (WGSR), data sets on the critical loads for lead, cadmium and mercury, and critical load violations (Pb, Cd, Hg). The results of work on the inclusion of biodiversity (BERN) cover data compilation, acquisition and integration concerning ecosystems, model validation and verification and the possible interpretation frame following the coupling with dynamic modeling. The future development and utilization of dynamic modeling covers model comparison, applicability, the preparation of a national data set and preparations concerning the interface to the BERN model.

  19. Book Reviews

    Directory of Open Access Journals (Sweden)

    Tilman Seebass et al.

    1979-10-01

    Full Text Available - David T. Hill, Ajip Rosidi, Laut biru langit biru. Pustaka Jaya (PJ 330, Jakarta, 1977. - J.E. van Lohuizen-De Leeuw, Mildred Archer, Indian popular painting in the India Office Library, Her Majesty’s Stationery Office, London 1977, 196 pp., 92 black-and-white and 6 coloured illus. - J.M. Pluvier, R.C. Kwantes, De ontwikkeling van de nationalistische beweging in Nederlandsch-Indië; bronnenpublikatie. Tweede stuk, medio 1923-1928. Groningen, Wolters-Noordhoff, 1978. xxxviii + 783 blz. Afkortingen, woordenlijst, registers. - J.J. Ras, Niels Mulder, Mysticism and everyday life in contemporary Java, Cultural persistence and change, issued under the auspices of the Institute of Southeast Asian Studies, Singapore University Press, 1978, XIX and 150 pages. - Danker H. Schaareman, Tilman Seebass et al., The Music of Lombok. A first survey, Forum Ethnomusicologicum, Series I: Basler Studien zur Ethnomusikologie 2, Francke-Verlag Bern, 1976. 71 blz., 8 platen, 1 kaart. - Danker H. Schaareman, Ernst Schlager, Rituelle Siebenton-Musik auf Bali, Herausgegeben von Hans Oesch. Forum Ethnomusicologicum, Series I: Basler Studien zur Ethnomusikologie I, Francke-Verlag Bern, 1976. Vol I: 222 pp., Vol II: 82 musical examples. - A. Teeuw, Rainer Carle, Rendras Gedichtsammlungen (1957-1972. Ein beitrag zur kenntnis der zeitgenössischen indonesischen Literatur. Veröffentlichungen des seminars für Indonesische und Südseesprachen der Universität Hamburg. Band 11 Hamburg 1977. Verlag von Dietrich Reimer in Berlin. IV und 385 Seiten.

  20. EUROPE: Swiss role

    International Nuclear Information System (INIS)

    Anon.

    1995-01-01

    On its continual round of CERN Member States, the European Committee for Future Accelerators (ECFA) met in Bern, Switzerland, in March. With CERN based in Geneva, and with a national research centre at the Paul Scherrer Institute (PSI), Villigen, Switzerland figures prominently in European particle physics. The Bern ECFA meeting provided a full picture of Swiss particle physics activities, project by project, and was prefaced by an overview by Claude Joseph of Lausanne. The number of experimental particle physicists in the country is about 200, with an academic staff of about 170. These are distributed among seven universities - Basel, Bern, Fribourg, Geneva, Lausanne, Neuchâtel and Zurich. In addition there are substantial research groups at ETH-Zurich and at PSI. Probably reflecting the proximity of CERN, the size of the national research community, when scaled to the population, is above the CERN Member State average. At CERN, there is a strong Swiss participation in research at the LEP electron-positron collider (concentrated on L3), with 44 physicists. There are also 33 physicists working at the LEAR low energy antiproton ring, in particular the Crystal Barrel and CP-LEAR studies. In addition there is interest in heavy ion research and in neutrino physics (NOMAD) as well as substantial participation in research and development work for experiments at the LHC. Away from CERN, there are 6 Swiss physicists working at the HERA electron-proton collider at DESY, Hamburg, with the national PSI programme involving about 40 physicists. (The PSI programme was covered at the Bern ECFA meeting by H.C. Walter.) Following the illustrious tradition of Fritz Zwicky, Switzerland also counts many astrophysicists. Theoretical physics, with a community of some 80 researchers, has a great tradition. Throughout the 20th century, leading Swiss research centres have been beacons of brilliance. Zurich, in particular, played a leading role, with Einstein, Schrödinger and Pauli among

  1. Interpretation of alumina/yttrium-aluminium garnet orientation relationships by geometric criteria

    International Nuclear Information System (INIS)

    Hay, R.S.; Matson, L.E.

    1991-01-01

    This paper reports on geometric criteria for low interface energy and interface structure were tested for the cubic-rhombohedral system YAG/alumina. Orientation relationships near (111)[110] a parallel (112)[110] y and facets on (111) a (112) y were observed in both sol-gel derived composites and directionally solidified eutectic composites. The Σ YAG = 12 near-CSL of 2[111], [110], [112] was inferred to be the preferred structural unit. Dislocations with b = 1/3[111] a and b = 1/2[110] a were observed and inferred to accommodate deviation from the structural unit, respectively. The [110] a, y direction met some of the criteria for an invariant line. Although the OR was explained by geometric criteria it would have been difficult to predict it with such criteria

  2. Tuberculin-purified protein derivative-, MPT-64-, and ESAT-6-stimulated gamma interferon responses in medical students before and after Mycobacterium bovis BCG vaccination and in patients with tuberculosis

    DEFF Research Database (Denmark)

    Johnson, P D; Stuart, R L; Grayson, M L

    1999-01-01

    QuantiFERON-TB (QIFN) (CSL Limited) is a whole-blood assay for the recognition of infection with Mycobacterium tuberculosis. QIFN measures gamma interferon (IFN-gamma) production when purified protein derivatives (PPDs) of mycobacteria are incubated with venous blood samples. The specificity...... of QIFN in medical students before and after BCG immunization was assessed, and sensitivity in patients with tuberculosis was assessed. Antigens were PPD derived from M. tuberculosis and two M. tuberculosis-specific proteins, ESAT-6 and MPT-64. Of 60 medical students, all of whom had 0-mm tuberculin skin...... tests (TSTs) at study entry, 58 (97%) were initially classified as negative for M. tuberculosis infection by PPD QIFN. Five months after BCG immunization, 7 of 54 students (13%) had a TST result of >/=10 mm and 11 of 54 students (20%) tested positive by PPD QIFN. ESAT-6- and MPT-64-stimulated IFN...

  3. Interferometry of light particles with a CsI(Tl) multi-detector in the collision: 16O(93.6 MeV/A) + 197Au

    International Nuclear Information System (INIS)

    Goujdami, D.

    1987-01-01

    Back angle emissions of light particles have been studied by interferometry in the 16 0 + 197 Au reaction. The experiment was performed at GANIL at 93,6 MeV/A. To achieve the correlation functions in the average backward direction we built entirely a compact multi-detector of Csl scintillators which was set up at 115 degrees to the beam direction. This work describes the relevant tests of the detector, data taking and data processing. The p-p, α-α, d-d, α-d, α-t correlations that we studied exhibit a complete damping of two body resonant nuclear effects. The most surprising result concerns the p-p correlation which, by its new shape, could be the signature of a de-excitation process in two steps. The ordering time of the 2 proton cascade would be of the order of 1.5*10 -21 s. (author) [fr

  4. The CSLA and CSLC Families: Recent Advances and Future Perspectives

    Directory of Open Access Journals (Sweden)

    Aaron Howard Liepman

    2012-05-01

    Full Text Available The CELLULOSE SYNTHASE (CESA superfamily of proteins contains several sub-families of closely related CELLULOSE SYNTHASE-LIKE (CSL sequences, Among these, the CSLA and CSLC families are closely related to each other and are the most evolutionarily divergent from the CESA family. Significant progress has been made with the functional characterization of CSLA and CSLC genes, which have been shown to encode enzymes with 1,4-B-glycan synthase activities involved in the biosynthesis of mannan and possibly xyloglucan backbones, respectively. This review examines recent work on the CSLA and CSLC families from evolutionary, molecular, and biochemical perspectives. We pose a series of questions, whose answers likely will provide further insight about the specific functions of members of the CSLA and CSLC families and about plant polysaccharide biosynthesis is general.

  5. PVeStA: A Parallel Statistical Model Checking and Quantitative Analysis Tool

    KAUST Repository

    AlTurki, Musab

    2011-01-01

    Statistical model checking is an attractive formal analysis method for probabilistic systems such as, for example, cyber-physical systems which are often probabilistic in nature. This paper is about drastically increasing the scalability of statistical model checking, and making such scalability of analysis available to tools like Maude, where probabilistic systems can be specified at a high level as probabilistic rewrite theories. It presents PVeStA, an extension and parallelization of the VeStA statistical model checking tool [10]. PVeStA supports statistical model checking of probabilistic real-time systems specified as either: (i) discrete or continuous Markov Chains; or (ii) probabilistic rewrite theories in Maude. Furthermore, the properties that it can model check can be expressed in either: (i) PCTL/CSL, or (ii) the QuaTEx quantitative temporal logic. As our experiments show, the performance gains obtained from parallelization can be very high. © 2011 Springer-Verlag.

  6. Tarawa to Okinawa: The Evolution of Amphibious Operations in the Pacific during World War II

    Science.gov (United States)

    2010-04-06

    successfully tested at Los Alamos, New Mexico. Tinian-based B-29 drops atomic bomb on Hiroshima. Tinian-based B-29 drops atomic bomb on Nagasaki. Russia...I< URO SHiM.\\ ~KAM!Y MothiiiOIO WAN tlTSUGEN SHIM!\\ Yli>:ABI SHIMA• ·~ i hMA,. SHIMA SHIIIIA :;nu~l·;;. U··be u’" OliO ru · ~Kil. SHlMA<:?r..EA MA...J .. _ ... ··j"··· JAPANESE DEFENSIVE OISPOS1TIONS 1 APRIL 1945 I - ~ .’!1 -4 lCXX 00 c?Sl29 tCORPS RES) lO ( [8Jr XX (Z17

  7. Progress of the new CSIRO-GEMOC nuclear microprobe: first results, performance and recent applications

    International Nuclear Information System (INIS)

    Ryan, C.G.; Cripps, G.; Sie, S.H.; Suter, G.F.; Jamieson, D.N.; Griffin, W.L.; Commonwealth Scientific and Industrial Research Organisation

    1999-01-01

    The new CSIRO-GEMOC Nuclear Microprobe (NMP) features a number of technical advances for high resolution, high sensitivity microanalysis. It was designed at the CSIRO and developed as collaboration between the CSlRO, the GEMOC key-centre at Macquarie University and the MARC group of the University of Melbourne. For imaging applications, it also features a software system using a powerful algorithm called Dynamic Analysis, developed at the CSIRO for unmixing elemental signatures in proton induced X-ray emission (PIXE) data, to provide a tool for rapid quantitative imaging of trace and major element spatial distribution in minerals. This paper reports on the performance of the NMP and examples of its application over the past 6 months since completion

  8. Grain boundary engineering for control of tellurium diffusion in GH3535 alloy

    Science.gov (United States)

    Fu, Cai-Tao; Yinling, Wang; Chu, Xiang-Wei; Jiang, Li; Zhang, Wen-Zhu; Bai, Qin; Xia, Shuang; Leng, Bin; Li, Zhi-Jun; Ye, Xiang-Xi; Liu, Fang

    2017-12-01

    The effect of grain boundary engineering (GBE) on the Te diffusion along the surface grain boundaries was investigated in GH3535 alloy. It can be found that GBE treatment increases obviously the fraction of low-Σ coincidence site lattice (CSL) boundaries, especially the Σ3 ones, and introduces the large-size grain clusters. When the as-received (AR) and GBE-treated (GBET) specimens were exposed to Te vapor, only Σ3 boundaries were found to be resistant to Te diffusion. From the cross section and the surface, the fewer Te-attacked grain boundaries and the thinner corrosion layer can be observed in the GBET sample. The improvement of resistance to Te diffusion in the GBET sample can be attributed to the large size grain-clusters associated with high proportion of the Σ3n boundaries.

  9. [Evaluation of music department students who passed the entrance exam with phonetogram (Voice Range Profile)].

    Science.gov (United States)

    Gökdoğan, Çağıl; Gökdoğan, Ozan; Şahin, Esra; Yılmaz, Metin

    2014-01-01

    This study aims to evaluate phonetogram data of the students in the department of music who passed the entrance exam. The phonetogram data of 44 individuals with a good voice quality in the department of music and age-matched individuals who were not trained in the field of music or not involved in music amateurish as the control group were compared. The voice of both groups were recorded using the voice range profile within the scope of Kay Elemetrics CSL (Model 4300 B) programmed. There was a significant difference in the voice range profile parameters including max Fo, Fo range, Fo range (St), min dB SPL, and max dB sound pressure level (pmusic is higher than the control group and that plays a major role in their acceptance to the department of music.

  10. Installation restoration program site investigation. Gulfport Field Training Site, Mississippi Air National Guard Gulfport-Biloxi Regional Airport Gulfport, Mississippi. Volume 2. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1992-12-01

    Site Investigation Report, Volume: 2. A Site Investigation was performed at 3 sites at the Combat Readiness Training Center, Gulfport-Bolixi. The 3 sites investigated are the: Former Fire Training Area (Site 1), the Former JP-4 Bulk Storage Area, Mill Road (Site 2), and the Motor Pool Above-Ground Diesel Fuel Storage Tank Area (Site 3). The findings of this investigation recommended further investigation at the Fire Training Area and the JP-4 Bulk Storage Tank. At Site 3 the levels of contamination did not represent a risk to human health or the environment; therefore, no further action was recommended. Volume two of this report consisted of the following Appendixes: Site Photographs (A), Well Inventory (B), Boring Logs (C), CSL Technical Memorandum (D), Data Review and Validation (E), GPS Memorandum (F), Level C Analytical Data Summary Tables (G), Slug Test (H), Special-Status Species (I), and Representative Species of Less Mobile Fish and Wildlife (J).

  11. Mutagenesis Strategies for the Enhancement of Glucose Oxidase Production from Corn Steep Liquor

    International Nuclear Information System (INIS)

    Khalaf, M.A.

    2007-01-01

    During screening of the twenty eight Aspergillus and Penicillium species for GOD production, only A. niger (84) was observed to release high extra (3.15 U ml -1 ) and intracellular (9.30 U mg -l ) GOD activity. Conidia of A. niger S4 were subjected to mutagenesis with UV radiation, nitrous acid, and sodium azide, as a single or combined treatments, and GOD activity was detected with the diffusion plate method. Out of 27 over producing mutants tested in shaken flasks, UVNA54 mutant strain showed the highest level of GOD activity (171 %, higher than the wild type). Using CSL at concentration 25 ml rl as the sol nutrient source, the enzyme activity was increased to 5.16 U ml -1 and 22.40 U mg -1 for extra and intracellular, respectively. Viable cell numbers of Pseudomonas and Salmonella spp. decreased as the concentration of the produced enzyme increased from 1 to 3 U ml -1

  12. Grain Boundary Engineering the Mechanical Properties of Allvac 718Plus(Trademark) Superalloy

    Science.gov (United States)

    Gabb, Timothy P.; Telesman, Jack; Garg, Anita; Lin, Peter; Provenzano, virgil; Heard, Robert; Miller, Herbert M.

    2010-01-01

    Grain Boundary Engineering can enhance the population of structurally-ordered "low S" Coincidence Site Lattice (CSL) grain boundaries in the microstructure. In some alloys, these "special" grain boundaries have been reported to improve overall resistance to corrosion, oxidation, and creep resistance. Such improvements could be quite beneficial for superalloys, especially in conditions which encourage damage and cracking at grain boundaries. Therefore, the effects of GBE processing on high-temperature mechanical properties of the cast and wrought superalloy Allvac 718Plus (Allvac ATI) were screened. Bar sections were subjected to varied GBE processing, and then consistently heat treated, machined, and tested at 650 C. Creep, tensile stress relaxation, and dwell fatigue crack growth tests were performed. The influences of GBE processing on microstructure, mechanical properties, and associated failure modes are discussed.

  13. 3D Microstructural Characterization of Uranium Oxide as a Surrogate Nuclear Fuel: Effect of Oxygen Stoichiometry on Grain Boundary Distributions

    Energy Technology Data Exchange (ETDEWEB)

    Rudman, K. [Arizona State Univ., Tempe, AZ (United States); Dickerson, P. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Byler, Darrin David [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Peralta, P. [Arizona State Univ., Tempe, AZ (United States); Lim, H. [Arizona State Univ., Tempe, AZ (United States); McDonald, R. [Arizona State Univ., Tempe, AZ (United States); Dickerson, R. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Mcclellan, Kenneth James [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-09-06

    The initial microstructure of an oxide fuel can play a key role in its performance. At low burn-ups, the diffusion of fission products can depend strongly on grain size and grain boundary (GB) characteristics, which in turn depend on processing conditions and oxygen stoichiometry. Serial sectioning techniques using Focused Ion Beam were developed to obtain Electron Backscatter Diffraction (EBSD) data for depleted UO2 pellets that were processed to obtain 3 different oxygen stoichiometries. The EBSD data were used to create 3D microstructure reconstructions and to gather statistical information on the grain and GB crystallography, with emphasis on identifying the character (twist, tilt, mixed) for GBs that meet the Coincident Site Lattice (CSL) criterion as well as GBs with the most common misorientation angles. Data on dihedral angles at triple points were also collected. The results were compared across different samples to understand effects of oxygen content on microstructure evolution.

  14. Improvement of corrosion resistance in austenitic stainless steel by grain boundary character distribution control

    International Nuclear Information System (INIS)

    Wang, Yun; Kaneda, Junya; Kasahara, Shigeki; Shigenaka, Naoto

    2012-01-01

    Strauss test, Coriou test and Huey test were conducted on a Type 316L austenitic stainless steel. Improvement in grain boundary corrosion resistance was verified after raising low Σ coincidence site lattice (CSL) grain boundary (GB) frequency by controlling grain boundary character distribution (GBCD). During crevice corrosion test under gamma-ray irradiation, initiation frequency of GB corrosion after GBCD controlled specimens decreased to 1/10 of GBCD uncontrolled counterpart along with lower depth of corrosion. Stress corrosion cracking (SCC) propagation rate of GBCD controlled specimen decreased to less than 1/2 of GBCD uncontrolled specimen in high temperature and high pressure water. Based on these results, we expect that GBCD control will improve corrosion resistance of austenitic material in a wide range of application and environment. (author)

  15. Conductive sub-layer of twisted-tape-induced swirl-flow heat transfer in vertical circular tubes with various twisted-tape inserts

    Science.gov (United States)

    Hata, K.; Fukuda, K.; Masuzaki, S.

    2018-04-01

    conductive sub-layer δ CSL and the nondimensional thickness of the conductive sub-layer y + CSL on the circular tubes with various twisted-tape inserts were determined on the basis of numerical solutions for the swirl velocities u sw ranging from 5.23 to 21.18 m/s. Correlations between the conductive sub-layer thickness δ CSL and the nondimensional thickness of the conductive sub-layer y + CSL for twisted-tape-induced swirl-flow heat transfer in a vertical circular tube were derived.

  16. Atypical Red Blood Cells Are Prevalent in California Sea Lion Pups Born during Anomalous Sea Surface Temperature Events.

    Science.gov (United States)

    Flores-Morán, Adriana; Banuet-Martínez, Marina; Elorriaga-Verplancken, Fernando R; García-Ortuño, Luis Enrique; Sandoval-Sierra, Julieta; Acevedo-Whitehouse, Karina

    To date, there is limited knowledge of the effects that abnormal sea surface temperature (SST) can have on the physiology of neonate pinnipeds. However, maternal nutritional deficiencies driven by alimentary restrictions would expectedly impact pinniped development and fitness, as an adequate supply of nutrients is essential for growth and proper functioning of all body systems, including red blood cell synthesis and clearance. Here, we investigated red blood cell morphology of California sea lion (CSL) pups from the San Benito Archipelago born during the 2014 and 2015 anomalously high SST events recorded in the northeastern Pacific Ocean. We examined whether atypical erythrocyte morphologies were more common in 2015, when the high SST event was more pronounced, and whether the stable isotope signature of pup fur, as an indicator of maternal feeding strategies, accounted for the number of atypical cells. Various atypical erythrocyte morphologies were more prevalent and more abundant than reference values. Evidence of iron deficiency was found in both years, and only pups born in 2014 showed evidence of active erythropoiesis. Microcytes and reticulocytes were more common in pups with higher isotopic δ 13 C and lower δ 15 N values, suggesting a probable relationship between maternal feeding strategies and the effect of climatic anomalies on red blood cell physiology of their pups. As developing pinnipeds require increased oxygen storage capacity for diving and foraging, the presence of atypical erythrocytes could be relevant to CSL pup fitness if the underlying cause is not reverted. This study is a first step to explore the effects that climatic alterations in the marine environment can have on the blood physiology of developing individuals.

  17. L-Serine overproduction with minimization of by-product synthesis by engineered Corynebacterium glutamicum.

    Science.gov (United States)

    Zhu, Qinjian; Zhang, Xiaomei; Luo, Yuchang; Guo, Wen; Xu, Guoqiang; Shi, Jinsong; Xu, Zhenghong

    2015-02-01

    The direct fermentative production of L-serine by Corynebacterium glutamicum from sugars is attractive. However, superfluous by-product accumulation and low L-serine productivity limit its industrial production on large scale. This study aimed to investigate metabolic and bioprocess engineering strategies towards eliminating by-products as well as increasing L-serine productivity. Deletion of alaT and avtA encoding the transaminases and introduction of an attenuated mutant of acetohydroxyacid synthase (AHAS) increased both L-serine production level (26.23 g/L) and its productivity (0.27 g/L/h). Compared to the parent strain, the by-products L-alanine and L-valine accumulation in the resulting strain were reduced by 87 % (from 9.80 to 1.23 g/L) and 60 % (from 6.54 to 2.63 g/L), respectively. The modification decreased the metabolic flow towards the branched-chain amino acids (BCAAs) and induced to shift it towards L-serine production. Meanwhile, it was found that corn steep liquor (CSL) could stimulate cell growth and increase sucrose consumption rate as well as L-serine productivity. With addition of 2 g/L CSL, the resulting strain showed a significant improvement in the sucrose consumption rate (72 %) and the L-serine productivity (67 %). In fed-batch fermentation, 42.62 g/L of L-serine accumulation was achieved with a productivity of 0.44 g/L/h and yield of 0.21 g/g sucrose, which was the highest production of L-serine from sugars to date. The results demonstrated that combined metabolic and bioprocess engineering strategies could minimize by-product accumulation and improve L-serine productivity.

  18. INTRAPERITONEAL DEXTROSE ADMINISTRATION AS AN ALTERNATIVE EMERGENCY TREATMENT FOR HYPOGLYCEMIC YEARLING CALIFORNIA SEA LIONS (ZALOPHUS CALIFORNIANUS).

    Science.gov (United States)

    Fravel, Vanessa A; Van Bonn, William; Gulland, Frances; Rios, Carlos; Fahlman, Andreas; Graham, James L; Havel, Peter J

    2016-03-01

    The Marine Mammal Center (TMMC) cares for malnourished California sea lion (CSL) (Zalophus californianus) pups and yearlings every year. Hypoglycemia is a common consequence of malnutrition in young CSLs. Administering dextrose during a hypoglycemic crisis is vital to recovery. Traditional veterinary approaches to treat hypoglycemia pose therapeutic challenges in otariids, as vascular access and catheter maintenance can be difficult. The current approach to a hypoglycemic episode at TMMC is to administer dextrose intravenously (i.v.) by medically trained personnel. Intraperitoneal (i.p.) dextrose administration is an attractive alternative to i.v. administration because volunteer staff with basic training can administer treatment instead of waiting for trained staff to treat. This study compares the effects of i.v., i.p., and no dextrose administration on serum glucose and insulin in clinically healthy, euglycemic CSL yearlings. Three groups of animals, consisting of five sea lions each, were treated with 500 mg/kg dextrose using one of the following routes: i.v., i.p., or no dextrose (control). A jugular catheter was placed, and blood samples were collected at times 0, 5, 15, 30, 60, 120, 180, and 240 min after dextrose administration. I.v. dextrose administration resulted in an increase of serum glucose concentrations from a baseline level of approximately 150 mg/dl to a peak of approximately 350 mg/dl. The resulting hyperglycemia persisted for approximately 2 hr and was associated with an attenuated plasma insulin response compared with most terrestrial mammals. Intraperitoneal dextrose administration resulted in increases of serum glucose to approximately 200 mg/dl, which gradually declined to baseline by 2 hr after dextrose administration. These data suggest that the initial treatment of a hypoglycemic crisis in young malnourished CSLs can be accomplished with i.p. dextrose, thus enabling minimally trained volunteer staff to respond immediately to a crisis

  19. Relativistic model for statevector reduction

    International Nuclear Information System (INIS)

    Pearle, P.

    1991-04-01

    A relativistic quantum field model describing statevector reduction for fermion states is presented. The time evolution of the states is governed by a Schroedinger equation with a Hamiltonian that has a Hermitian and a non-Hermitian part. In addition to the fermions, the Hermitian part describes positive and negative energy mesons of equal mass, analogous to the longitudinal and timelike photons of electromagnetism. The meson-field-sum is coupled to the fermion field. This ''dresses'' each fermion so that, in the extreme nonrelativistic limit (non-moving fermions), a fermion in a position eigenstate is also in an eigenstate of the meson-field-difference with the Yukawa-potential as eigenvalue. However, the fermions do not interact: this is a theory of free dressed fermions. It is possible to obtain a stationary normalized ''vacuum'' state which satisfies two conditions analogous to the gauge conditions of electromagnetism (i.e., that the meson-field-difference, as well as its time derivative, give zero when applied to the vacuum state), to any desired degree of accuracy. The non-Hermitian part of the Hamiltonian contains the coupling of the meson-field-difference to an externally imposed c-number fluctuating white noise field, of the CSL (Continuous Spontaneous Localization) form. This causes statevector reduction, as is shown in the extreme nonrelativistic limit. For example, a superposition of spatially separated wavepackets of a fermion will eventually be reduced to a single wavepacket: the meson-field-difference discriminates among the Yukawa-potential ''handles'' attached to each wavepacket, thereby selecting one wavepacket to survive by the CSL mechanism. Analysis beyond that given in this paper is required to see what happens when the fermions are allowed to move. (It is possible that the ''vacuum'' state becomes involved in the dynamics so that the ''gauge'' conditions can no longer be maintained.) It is shown how to incorporate these ideas into quantum

  20. Prospecting for Energy-Rich Renewable Raw Materials: Sorghum Stem Case Study.

    Directory of Open Access Journals (Sweden)

    Caitlin S Byrt

    Full Text Available Sorghum vegetative tissues are becoming increasingly important for biofuel production. The composition of sorghum stem tissues is influenced by genotype, environment and photoperiod sensitivity, and varies widely between varieties and also between different stem tissues (outer rind vs inner pith. Here, the amount of cellulose, (1,3;1,4-β-glucan, arabinose and xylose in the stems of twelve diverse sorghum varieties, including four photoperiod-sensitive varieties, was measured. At maturity, most photoperiod-insensitive lines had 1% w/w (1,3;1,4-β-glucan in stem pith tissue whilst photoperiod-sensitive varieties remained in a vegetative stage and accumulated up to 6% w/w (1,3;1,4-β-glucan in the same tissue. Three sorghum lines were chosen for further study: a cultivated grain variety (Sorghum bicolor BTx623, a sweet variety (S. bicolor Rio and a photoperiod-sensitive wild line (S. bicolor ssp. verticilliflorum Arun. The Arun line accumulated 5.5% w/w (1,3;1,4-β-glucan and had higher SbCslF6 and SbCslH3 transcript levels in pith tissues than did photoperiod-insensitive varieties Rio and BTx623 (<1% w/w pith (1,3;1,4-β-glucan. To assess the digestibility of the three varieties, stem tissue was treated with either hydrolytic enzymes or dilute acid and the release of fermentable glucose was determined. Despite having the highest lignin content, Arun yielded significantly more glucose than the other varieties, and theoretical calculation of ethanol yields was 10 344 L ha-1 from this sorghum stem tissue. These data indicate that sorghum stem (1,3;1,4-β-glucan content may have a significant effect on digestibility and bioethanol yields. This information opens new avenues of research to generate sorghum lines optimised for biofuel production.

  1. A NOTCH-sensitive uPAR-regulated oncolytic adenovirus effectively suppresses pancreatic tumor growth and triggers synergistic anticancer effects with gemcitabine and nab-paclitaxel.

    Science.gov (United States)

    Mato-Berciano, Ana; Raimondi, Giulia; Maliandi, Maria Victoria; Alemany, Ramon; Montoliu, Lluis; Fillat, Cristina

    2017-04-04

    Notch signaling pathway is an embryonic program that becomes reactivated in pancreatic cancer and contributes to cancer stem cell (CSC) maintenance. We explored the concept of oncolytic adenoviral activity in response to Notch activation signaling, in the context of a chimeric promoter with uPAR regulatory sequences, as a strategy to drive its activity in neoplastic and CSC. We explored the advantages of a chemo-virotherapy approach based on synergistic combinations. Regulatory sequences recognized by the transcriptional factor CSL upstream a minimal uPAR promoter were engineered in adenoviral vectors and in the oncolytic adenovirus AdNuPARmE1A. Viral response to Notch signaling, and viral potency in cell lines and pancreatic cancer stem cells (PCSC) was tested. Preclinical toxicity and antitumor efficacy in xenografts and Patient-derived xenografts (PDX) mouse models was evaluated, as unimodal or in combination with gemcitabine+nab-paclitaxel. Mechanistic studies were conducted to explore the synergism of combined therapies.We demonstrate that CSL-binding site optimized-engineered sequences respond to Notch activation in AdNuPARmLuc and AdNuPARmE1A. AdNuPARmE1A showed strong lytic effects in pancreatic cancer cell lines and PCSC. AdNuPARmE1A displayed attenuated activity in normal tissues, but robust antitumor effects in xenograft and PDX models, leading to a reduced capacity of treated tumors to form tumorspheres. Chemo-virotherapy treatment enlarged therapeutic response in both tumor models. Synergistic effects of the combination resulted from viral sensitization of apoptotic cell death triggered by chemotherapy.In summary we present a novel effective oncolytic adenovirus, AdNuPARmE1A that reduces PCSC and presents synergistic effects with gemcitabine and nab-paclitaxel, supporting further clinical development.

  2. Prospecting for Energy-Rich Renewable Raw Materials: Sorghum Stem Case Study.

    Science.gov (United States)

    Byrt, Caitlin S; Betts, Natalie S; Tan, Hwei-Ting; Lim, Wai Li; Ermawar, Riksfardini A; Nguyen, Hai Yen; Shirley, Neil J; Lahnstein, Jelle; Corbin, Kendall; Fincher, Geoffrey B; Knauf, Vic; Burton, Rachel A

    2016-01-01

    Sorghum vegetative tissues are becoming increasingly important for biofuel production. The composition of sorghum stem tissues is influenced by genotype, environment and photoperiod sensitivity, and varies widely between varieties and also between different stem tissues (outer rind vs inner pith). Here, the amount of cellulose, (1,3;1,4)-β-glucan, arabinose and xylose in the stems of twelve diverse sorghum varieties, including four photoperiod-sensitive varieties, was measured. At maturity, most photoperiod-insensitive lines had 1% w/w (1,3;1,4)-β-glucan in stem pith tissue whilst photoperiod-sensitive varieties remained in a vegetative stage and accumulated up to 6% w/w (1,3;1,4)-β-glucan in the same tissue. Three sorghum lines were chosen for further study: a cultivated grain variety (Sorghum bicolor BTx623), a sweet variety (S. bicolor Rio) and a photoperiod-sensitive wild line (S. bicolor ssp. verticilliflorum Arun). The Arun line accumulated 5.5% w/w (1,3;1,4)-β-glucan and had higher SbCslF6 and SbCslH3 transcript levels in pith tissues than did photoperiod-insensitive varieties Rio and BTx623 (<1% w/w pith (1,3;1,4)-β-glucan). To assess the digestibility of the three varieties, stem tissue was treated with either hydrolytic enzymes or dilute acid and the release of fermentable glucose was determined. Despite having the highest lignin content, Arun yielded significantly more glucose than the other varieties, and theoretical calculation of ethanol yields was 10 344 L ha-1 from this sorghum stem tissue. These data indicate that sorghum stem (1,3;1,4)-β-glucan content may have a significant effect on digestibility and bioethanol yields. This information opens new avenues of research to generate sorghum lines optimised for biofuel production.

  3. Conceptualisation of knowledge construction in community service-learning programmes in nursing education.

    Science.gov (United States)

    Mthembu, Sindi Z; Mtshali, Fikile G

    2013-01-01

    Practices in higher education have been criticised for not developing and preparing students for the expertise required in real environments. Literature reports that educational programmes tend to favour knowledge conformation rather than knowledge construction; however, community service learning (CSL) is a powerful pedagogical strategy that encourages students to make meaningful connections between the content in the classroom and real-life experiences as manifested by the communities. Through CSL, learning is achieved by the active construction of knowledge supported by multiple perspectives within meaningful real contexts, and the social interactions amongst students are seen to play a critical role in the processes of learning and cognition. This article reflects facilitators’ perspective of the knowledge construction process as used with students doing community service learning in basic nursing programmes. The aim of this article was to conceptualise the phenomenon of knowledge construction and thereby provide educators with a shared meaning and common understanding, and to analyse the interaction strategies utilised by nurse educators in the process of knowledge construction in community service-learning programmes in basic nursing education. A qualitative research approach based on a grounded theory research design was used in this article. Two nursing education institutions were purposively selected. Structured interviews were conducted with 16 participants. The results revealed that the knowledge construction in community service-learning programmes is conceptualised as having specific determinants, including the use of authentic health-related problems, academic coaching through scaffolding, academic discourse-dialogue, interactive learning in communities of learners, active learning, continuous reflection as well as collaborative and inquiry-based learning. Upon completion of an experience, students create and test generated knowledge in different

  4. Impact of the 2015 El Niño-Southern Oscillation on the Abundance and Foraging Habits of Guadalupe Fur Seals and California Sea Lions from the San Benito Archipelago, Mexico.

    Directory of Open Access Journals (Sweden)

    Fernando R Elorriaga-Verplancken

    Full Text Available The abundance of California sea lions (Zalophus californianus (CSLs and Guadalupe fur seals (Arctocephalus philippii townsendi (GFSs from the San Benito Archipelago (SBA was determined through nine monthly surveys in 2014-2015. Assessment of their foraging habits was examined based on the isotopic analysis of pups (maternal indicators (SIAR/SIBER-R. Environmental variability between 2014 and 2015 was also analyzed, in terms of sea surface temperature (SST and chlorophyll (Chl-a concentration. Both otariids reached their highest abundance in July of both years; however, relative to 2014, the 2015 survey showed a 59.7% decline in the total GFS abundance and a 42.9% decrease of GFS pups, while total CSL abundance decreased 52.0% and CSL pup presence decreased in 61.7%. All monthly surveys for both otariids showed a similar trend (>50% decrease in 2015. Compared to 2014, the 2015 GFSs isotopic niche was three times larger (2.0 in 2015, 0.6 in 2014 and the δ13C was significantly lower. CSLs also showed significantly lower δ13C and higher δ15N in 2015. Interannual segregation was greater for CSLs, and their pup body mass was also significantly lower during the 2015 breeding season (mean = 8.7 kg than in the same season of 2014 (mean = 9.9 kg. The decrease in δ13C for both otariids reflected a more oceanic foraging; most likely associated with the decline in primary productivity in surrounding areas to the SBA, related to a higher SST caused by the 2015 ENSO, with a subsequent increase in foraging effort. These would explain the fewer observed individuals on land, especially pups, which showed diminished body condition (CSLs. This study highlights the importance of marine mammals as sentinel species that respond dynamically to changes in environment, providing valuable information on the effect of ENSO on pinnipeds in Mexican waters.

  5. Atmospheric forcing on the seasonal variability of sea level at Cochin, southwest coast of India

    Science.gov (United States)

    Srinivas, K.; Dinesh Kumar, P. K.

    2006-07-01

    The seasonal cycles of some atmospheric parameters at Cochin (southwest coast of India) have been studied with a specific emphasis on the role played by them in forcing the seasonal sea level. Equatorward along-shore wind stress as well as equatorward volume transport by coastal currents along the Indian peninsula could play an important role in the sea level low during the premonsoon and southwest monsoon seasons. During postmonsoon season, along-shore wind stress plays no major role in the high sea level whereas this could be due to the poleward volume transport by the coastal along-shore currents. Atmospheric pressure and river discharge do not seem to influence much the sea level during the southwest monsoon period, even though the river discharge during that period is considerable. The sea level was minimal during the southwest monsoon season, when the river discharge was at its annual maximum. The difference between the seasonal march of observed and pressure corrected sea level (CSL) was not significant for the study region. Harmonic analysis of the climatological data on the various parameters revealed that air temperature is the only parameter with a dominance of the semi-annual over the annual cycle. Cross-shore wind stress indicated strong interannual variability whereas relative density showed strong seasonal variability. The climatological seasonal cycles of CSL at eight other tide gauge stations along the west coast of the Indian subcontinent are also examined, to assess the role of various forcings on the seasonal sea level cycle. The signatures of El Nino-Southern Oscillation (ENSO) phenomenon could be seen in some of the parameters (SST, air temperature, atmospheric pressure, along-shore wind stress, relative density and sea level). The signature of ENSO was particularly strong in the case of atmospheric pressure followed by relative density, the variance accounted by the relationship being 47% and 16%, respectively.

  6. Use of Potato Nitrogen Concentrate in the Production of α-Amylase by Aspergillus oryzae

    Directory of Open Access Journals (Sweden)

    Eric Thaller

    2007-01-01

    Full Text Available The influence of various nitrogen sources and media supplements on α-amylase (EC 3.2.1.1 formation by Aspergillus oryzae ATCC 1011 was investigated in shake flask experiments and batch fermentations. Both inorganic and organic nitrogen-containing supplements have been applied, while corn starch and ammonium sulphate were used as the major source of carbon and nitrogen, respectively. Shake flask experiments revealed that potato nitrogen concentrate (PNC is almost equivalent to corn steep liquor (CSL in supporting amylase formation. A pretreatment step consisting of clarification of the turbid material did not show any significant effect. The replacement of the inorganic nitrogen source by sodium nitrate led to lower enzyme yields. Other complex supplements may reduce the enzyme level formed, e.g. casein hydrolysate, or increase the amylase titre slightly, e.g. yeast extract or malt extract. Cultivations in instrumented bench top reactors on media supplemented with PNC led to higher cell growth rates and yields of α-amylase in comparison with the medium without any supplement. Replacement of PNC by CSL revealed a slightly increased enzyme level, which is in the range of 9–17 % after 100 h of cultivation. Only minor differences were revealed in the growth kinetics and enzyme formation when PNC was used as the sole nitrogen source, replacing a mixture of soybean meal, yeast extract, malt extract and casein hydrolysate in bioreactor cultivations with lactose as the carbon source. However, metabolic differences as seen from the course of dissolved oxygen tension (DOT, α-amino nitrogen concentration and the amount of acid needed to maintain a constant pH were observed.

  7. Integrative analysis and expression profiling of secondary cell wall genes in C4 biofuel model Setaria italica reveals targets for lignocellulose bioengineering

    Directory of Open Access Journals (Sweden)

    Mehanathan eMuthamilarasan

    2015-11-01

    Full Text Available Several underutilized grasses have excellent potential for use as bioenergy feedstock due to their lignocellulosic biomass. Genomic tools have enabled identification of lignocellulose biosynthesis genes in several sequenced plants. However, the non-availability of whole genome sequence of bioenergy grasses hinders the study on bioenergy genomics and their genomics-assisted crop improvement. Foxtail millet (Setaria italica L.; Si is a model crop for studying systems biology of bioenergy grasses. In the present study, a systematic approach has been used for identification of gene families involved in cellulose (CesA/Csl, callose (Gsl and monolignol biosynthesis (PAL, C4H, 4CL, HCT, C3H, CCoAOMT, F5H, COMT, CCR, CAD and construction of physical map of foxtail millet. Sequence alignment and phylogenetic analysis of identified proteins showed that monolignol biosynthesis proteins were highly diverse, whereas CesA/Csl and Gsl proteins were homologous to rice and Arabidopsis. Comparative mapping of foxtail millet lignocellulose biosynthesis genes with other C4 panicoid genomes revealed maximum homology with switchgrass, followed by sorghum and maize. Expression profiling of candidate lignocellulose genes in response to different abiotic stresses and hormone treatments showed their differential expression pattern, with significant higher expression of SiGsl12, SiPAL2, SiHCT1, SiF5H2 and SiCAD6 genes. Further, due to the evolutionary conservation of grass genomes, the insights gained from the present study could be extrapolated for identifying genes involved in lignocellulose biosynthesis in other biofuel species for further characterization.

  8. Integrative analysis and expression profiling of secondary cell wall genes in C4 biofuel model Setaria italica reveals targets for lignocellulose bioengineering.

    Science.gov (United States)

    Muthamilarasan, Mehanathan; Khan, Yusuf; Jaishankar, Jananee; Shweta, Shweta; Lata, Charu; Prasad, Manoj

    2015-01-01

    Several underutilized grasses have excellent potential for use as bioenergy feedstock due to their lignocellulosic biomass. Genomic tools have enabled identification of lignocellulose biosynthesis genes in several sequenced plants. However, the non-availability of whole genome sequence of bioenergy grasses hinders the study on bioenergy genomics and their genomics-assisted crop improvement. Foxtail millet (Setaria italica L.; Si) is a model crop for studying systems biology of bioenergy grasses. In the present study, a systematic approach has been used for identification of gene families involved in cellulose (CesA/Csl), callose (Gsl) and monolignol biosynthesis (PAL, C4H, 4CL, HCT, C3H, CCoAOMT, F5H, COMT, CCR, CAD) and construction of physical map of foxtail millet. Sequence alignment and phylogenetic analysis of identified proteins showed that monolignol biosynthesis proteins were highly diverse, whereas CesA/Csl and Gsl proteins were homologous to rice and Arabidopsis. Comparative mapping of foxtail millet lignocellulose biosynthesis genes with other C4 panicoid genomes revealed maximum homology with switchgrass, followed by sorghum and maize. Expression profiling of candidate lignocellulose genes in response to different abiotic stresses and hormone treatments showed their differential expression pattern, with significant higher expression of SiGsl12, SiPAL2, SiHCT1, SiF5H2, and SiCAD6 genes. Further, due to the evolutionary conservation of grass genomes, the insights gained from the present study could be extrapolated for identifying genes involved in lignocellulose biosynthesis in other biofuel species for further characterization.

  9. Adhesion of mutans streptococci to self-ligating ceramic brackets: in vivo quantitative analysis with real-time polymerase chain reaction.

    Science.gov (United States)

    Jung, Woo-Sun; Yang, Il-Hyung; Lim, Won Hee; Baek, Seung-Hak; Kim, Tae-Woo; Ahn, Sug-Joon

    2015-12-01

    To analyze in vivo mutans streptococci (MS) adhesion to self-ligating ceramic brackets [Clarity-SL (CSL) and Clippy-C (CC)] and the relationships between bacterial adhesion and oral hygiene indices. Four central incisor brackets from the maxilla and mandible were collected from 40 patients (20 patients per each bracket type) at debonding immediately after plaque and gingival indices were measured. Adhesions of Streptococcus mutans, S. sobrinus, and total bacteria were quantitatively determined using real-time polymerase chain reaction after genomic DNA was extracted. Factorial analysis of variance was used to analyze bacterial adhesion to the brackets with respect to the bracket type and jaw position. Correlation coefficients were calculated to determine the relationships of bacterial adhesion to oral hygiene indices. Adhesion of total bacteria and S. mutans to CSL was higher than that to CC (P brackets was higher than that to the maxillary ones (P brackets were higher than that in the mandibular ones (P brackets and jaw positions. Interestingly, no significant relationships were found between bacterial adhesions and oral hygiene indices. Complex bracket configurations may significantly influence bacterial adhesion to orthodontic brackets. Further in vivo study using bracket raw materials will help to define the relationships between bacteria adhesion and enamel demineralization. Because oral hygiene indices were not significantly correlated with adhesions of MS to self-ligating ceramic brackets, careful examinations around the brackets should be needed to prevent enamel demineralization, regardless of oral hygiene status. © The Author 2015. Published by Oxford University Press on behalf of the European Orthodontic Society. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  10. Multi-scale modeling and analysis of convective boiling: towards the prediction of CHF in rod bundles

    International Nuclear Information System (INIS)

    Niceno, B.; Sato, Y.; Badillo, A.; Andreani, M.

    2010-01-01

    In this paper we describe current activities on the project Multi-Scale Modeling and Analysis of convective boiling (MSMA), conducted jointly by the Paul Scherrer Institute (PSI) and the Swiss Nuclear Utilities (Swissnuclear). The long-term aim of the MSMA project is to formulate improved closure laws for Computational Fluid Dynamics (CFD) simulations for prediction of convective boiling and eventually of the Critical Heat Flux (CHF). As boiling is controlled by the competition of numerous phenomena at various length and time scales, a multi-scale approach is employed to tackle the problem at different scales. In the MSMA project, the scales on which we focus range from the CFD scale (macro-scale), bubble size scale (meso-scale), liquid micro-layer and triple interline scale (micro-scale), and molecular scale (nano-scale). The current focus of the project is on micro- and meso- scales modeling. The numerical framework comprises a highly efficient, parallel DNS solver, the PSI-BOIL code. The code has incorporated an Immersed Boundary Method (IBM) to tackle complex geometries. For simulation of meso-scales (bubbles), we use the Constrained Interpolation Profile method: Conservative Semi-Lagrangian 2nd order (CIP-CSL2). The phase change is described either by applying conventional jump conditions at the interface, or by using the Phase Field (PF) approach. In this work, we present selected results for flows in complex geometry using the IBM, selected bubbly flow simulations using the CIP-CSL2 method and results for phase change using the PF approach. In the subsequent stage of the project, the importance of effects of nano-scale processes on the global boiling heat transfer will be evaluated. To validate the models, more experimental information will be needed in the future, so it is expected that the MSMA project will become the seed for a long-term, combined theoretical and experimental program

  11. Characterization of microstructure and texture across dissimilar super duplex/austenitic stainless steel weldment joint by austenitic filler metal

    International Nuclear Information System (INIS)

    Eghlimi, Abbas; Shamanian, Morteza; Eskandarian, Masoomeh; Zabolian, Azam; Szpunar, Jerzy A.

    2015-01-01

    The evolution of microstructure and texture across an as-welded dissimilar UNS S32750 super duplex/UNS S30403 austenitic stainless steel joint welded by UNS S30986 (AWS A5.9 ER309LMo) austenitic stainless steel filler metal using gas tungsten arc welding process was evaluated by optical micrography and EBSD techniques. Due to their fabrication through rolling process, both parent metals had texture components resulted from deformation and recrystallization. The weld metal showed the highest amount of residual strain and had large austenite grain colonies of similar orientations with little amounts of skeletal ferrite, both oriented preferentially in the < 001 > direction with cub-on-cube orientation relationship. While the super duplex stainless steel's heat affected zone contained higher ferrite than its parent metal, an excessive grain growth was observed at the austenitic stainless steel's counterpart. At both heat affected zones, austenite underwent some recrystallization and formed twin boundaries which led to an increase in the fraction of high angle boundaries as compared with the respective base metals. These regions showed the least amount of residual strain and highest amount of recrystallized austenite grains. Due to the static recrystallization, the fraction of low degree of fit (Σ) coincident site lattice boundaries, especially Σ3 boundaries, was increased in the austenitic stainless steel heat affected zone, while the formation of subgrains in the ferrite phase increased the content of < 5° low angle boundaries at that of the super duplex stainless steel. - Graphical abstract: Display Omitted - Highlights: • Extensive grain growth in the HAZ of austenitic stainless steel was observed. • Intensification of < 100 > orientated grains was observed adjacent to both fusion lines. • Annealing twins with Σ3 CSL boundaries were formed in the austenite of both HAZ. • Cub-on-cube OR was observed between austenite and ferrite in the weld

  12. Ultrathin HfON/SiO2 dual tunneling layer for improving the electrical properties of metal–oxide–nitride–oxide–silicon memory

    International Nuclear Information System (INIS)

    Liu, L.; Xu, J.P.; Chen, J.X.; Ji, F.; Huang, X.D.; Lai, P.T.

    2012-01-01

    A high-k gate stack structure with ultrathin HfON/SiO 2 as dual tunneling layer (DTL), AlN as charge storage layer (CSL) and HfAlO as blocking layer (BL) is proposed to make a charge-trapping-type metal–oxide–nitride–oxide–silicon non-volatile memory device by employing in-situ sputtering method. The validity of the structure is examined and confirmed by transmission electron microscopy. The memory window, program/erase, endurance and retention properties are investigated and compared with similar gate stack structure with Si 3 N 4 /SiO 2 as DTL, HfO 2 as CSL and Al 2 O 3 as BL. Results show that a large memory window of 3.55 V at a program/erase (P/E) voltage of + 8 V/− 15 V, high P/E speed, and good endurance and retention characteristic can be achieved using the Au/ HfAlO/AlN/(HfON/SiO 2 )/Si gate stack structure. The main mechanisms lie in the enhanced electron injection through the ultrathin high-k HfON/SiO 2 DTL with suitable band offset, high trapping efficiency of the high-k AlN material, and effective blocking role of the high-k HfAlO BL. - Highlights: ► An Au/HfAlO/AlN/(HfON/SiO 2 )/Si high-k gate stack structure is proposed. ► A band-engineered dual tunneling layer (HfON/SiO 2 ) is proposed and prepared. ► A good trade-off among the memory characteristics is obtained. ► In-situ sputtering method is employed to fabricate the gate stack structure.

  13. Characterization of microstructure and texture across dissimilar super duplex/austenitic stainless steel weldment joint by austenitic filler metal

    Energy Technology Data Exchange (ETDEWEB)

    Eghlimi, Abbas, E-mail: a.eghlimi@ma.iut.ac.ir [Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111 (Iran, Islamic Republic of); Shamanian, Morteza [Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111 (Iran, Islamic Republic of); Eskandarian, Masoomeh [Department of Materials Engineering, Shiraz University, Shiraz 71348-51154 (Iran, Islamic Republic of); Zabolian, Azam [Department of Natural Resources, Isfahan University of Technology, Isfahan 84156-83111 (Iran, Islamic Republic of); Szpunar, Jerzy A. [Department of Mechanical Engineering, University of Saskatchewan, Saskatoon, SK S7N 5A9 (Canada)

    2015-08-15

    The evolution of microstructure and texture across an as-welded dissimilar UNS S32750 super duplex/UNS S30403 austenitic stainless steel joint welded by UNS S30986 (AWS A5.9 ER309LMo) austenitic stainless steel filler metal using gas tungsten arc welding process was evaluated by optical micrography and EBSD techniques. Due to their fabrication through rolling process, both parent metals had texture components resulted from deformation and recrystallization. The weld metal showed the highest amount of residual strain and had large austenite grain colonies of similar orientations with little amounts of skeletal ferrite, both oriented preferentially in the < 001 > direction with cub-on-cube orientation relationship. While the super duplex stainless steel's heat affected zone contained higher ferrite than its parent metal, an excessive grain growth was observed at the austenitic stainless steel's counterpart. At both heat affected zones, austenite underwent some recrystallization and formed twin boundaries which led to an increase in the fraction of high angle boundaries as compared with the respective base metals. These regions showed the least amount of residual strain and highest amount of recrystallized austenite grains. Due to the static recrystallization, the fraction of low degree of fit (Σ) coincident site lattice boundaries, especially Σ3 boundaries, was increased in the austenitic stainless steel heat affected zone, while the formation of subgrains in the ferrite phase increased the content of < 5° low angle boundaries at that of the super duplex stainless steel. - Graphical abstract: Display Omitted - Highlights: • Extensive grain growth in the HAZ of austenitic stainless steel was observed. • Intensification of < 100 > orientated grains was observed adjacent to both fusion lines. • Annealing twins with Σ3 CSL boundaries were formed in the austenite of both HAZ. • Cub-on-cube OR was observed between austenite and ferrite in the weld

  14. Sphere-forming cell subpopulations with cancer stem cell properties in human hepatoma cell lines

    Directory of Open Access Journals (Sweden)

    Chen Lei

    2011-06-01

    Full Text Available Abstract Background Cancer stem cells (CSCs are regarded as the cause of tumor formation and recurrence. The isolation and identification of CSCs could help to develop novel therapeutic strategies specifically targeting CSCs. Methods Human hepatoma cell lines were plated in stem cell conditioned culture system allowed for sphere forming. To evaluate the stemness characteristics of spheres, the self-renewal, proliferation, chemoresistance, tumorigenicity of the PLC/PRF/5 sphere-forming cells, and the expression levels of stem cell related proteins in the PLC/PRF/5 sphere-forming cells were assessed, comparing with the parental cells. The stem cell RT-PCR array was performed to further explore the biological properties of liver CSCs. Results The PLC/PRF/5, MHCC97H and HepG2 cells could form clonal nonadherent 3-D spheres and be serially passaged. The PLC/PRF/5 sphere-forming cells possessed a key criteria that define CSCs: persistent self-renewal, extensive proliferation, drug resistance, overexpression of liver CSCs related proteins (Oct3/4, OV6, EpCAM, CD133 and CD44. Even 500 sphere-forming cells were able to form tumors in NOD/SCID mice, and the tumor initiating capability was not decreased when spheres were passaged. Besides, downstream proteins DTX1 and Ep300 of the CSL (CBF1 in humans, Suppressor of hairless in Drosophila and LAG1 in C. elegans -independent Notch signaling pathway were highly expressed in the spheres, and a gamma-secretase inhibitor MRK003 could significantly inhibit the sphere formation ability. Conclusions Nonadherent tumor spheres from hepatoma cell lines cultured in stem cell conditioned medium possess liver CSC properties, and the CSL-independent Notch signaling pathway may play a role in liver CSCs.

  15. Computation of Estonian CORS data using Bernese 5.2 and Gipsy 6.4 softwares

    Science.gov (United States)

    Kollo, Karin; Kall, Tarmo; Liibusk, Aive

    2017-04-01

    GNSS permanent station network in Estonia (ESTREF) was established already in 2007. In 2014-15 extensive reconstruction of ESTREF was carried out, including the establishment of 18 new stations, change of the hardware in CORS stations as well as establishing GNSS-RTK service for the whole Estonia. For GNSS-RTK service one needs precise coordinates in well-defined reference frame, i.e., ETRS89. For long time stability of stations and time-series analysis the re-processing of Estonian CORS data is ongoing. We re-process data from 2007 until 2015 with program Bernese GNSS 5.2 (Dach, 2015). For the set of ESTREF stations established in 2007, we perform as well computations with GIPSY 6.4 software (Ries et al., 2015). In the computations daily GPS-only solution was used. For precise orbits, final products from CODE (CODE analysis centre at the Astronomical Institute of the University of Bern) and JPL (Jet Propulsion Laboratory) for Bernese and GIPSY solutions were used, respectively. The cut-off angle was set to 10 degrees in order to avoid near-field multipath influence. In GIPSY, precise point positioning method with fixing ambiguities was used. Bernese calculations were performed based on double difference processing. Antenna phase centers were modelled based on igs08.atx and epnc_08.atx files. Vienna mapping function was used for mapping tropospheric delays. For the GIPSY solution, the higher order ionospheric term was modelled based on IRI-2012b model. For the Bernese solution higher order ionospheric term was neglected. FES2004 ocean tide loading model was used for the both computation strategies. As a result, two solutions using different scientific GNSS computation programs were obtained. The results from Bernese and GIPSY solutions were compared, using station repeatability values, RMS and coordinate differences. KEYWORDS: GNSS reference station network, Bernese GNSS 5.2, Gipsy 6.4, Estonia. References: Dach, R., S. Lutz, P. Walser, P. Fridez (Eds); 2015

  16. Quantification of the cumulative effects of river training works on the basin scale with 2D flood modelling

    Science.gov (United States)

    Zischg, Andreas Paul; Felder, Guido; WWeingartner, Rolf

    2015-04-01

    The catchment of the river Aare upstream of Bern, Switzerland, with an area of approx. 3000 km2 is a complex network of sub-catchments with different runoff characteristics; it also includes two larger lakes. Most of the rivers were regulated in the 18th century. An important regulation, however, was realised as early as in the 17th century. For this catchment, the worst case flood event was identified and its consequences were analysed. Beside the hydro-meteorological characteristics, an important basis to model the worst case flood is to understand the non-linear effects of flood retention in the valley bottom and in the lakes. The aim of this study was to compare these effects based on both the current river network and the historic one prior to the main river training works. This allows to quantify the human impacts. Methodologically, we set up a coupled 2D flood model representing the floodplains of the river Aare as well as of the tributaries Lombach, Lütschine, Zulg, Rotache, Chise and Guerbe. The flood simulation was made in 2D with the software BASEMENT-ETH (Vetsch et al. 2014). The model was calibrated by means of reproducing the large floods in August 2005 and the bankfull discharge for all river reaches. The model computes the discharge at the outlet of the Aare catchment at Bern by routing all discharges from the sub-catchments through the river reaches and their floodplains. With this, the modulation of the input hydrographs by widespread floodings in the floodplains can be quantified. The same configuration was applied on the basis of reconstructed digital terrain models representing the landscape and the river network before the first significant river training works had been realised. This terrain model was reconstructed by georeferencing and digitalizing historic maps and cross-sections combined with the mapping of the geomorphologic evidences of former river structures in non-modified areas. The latter mapping procedure was facilitated by the

  17. Standardization of GPS data processing

    International Nuclear Information System (INIS)

    Park, Pil Ho

    2001-06-01

    A nationwide GPS network has been constructed with about 60 permanent GPS stations after late 1990s in Korea. For using the GPS in variety of application area like crustal deformation, positioning, or monitoring upper atmosphere, it is necessary to have ability to process the data precisely. Now Korea Astronomy Observatory has the precise GPS data processing technique in Korea because it is difficult to understand characteristics of the parameters we want to estimate, resolve the integer ambiguity, and analyze many errors. There are three reliable GPS data processing software in the world ; Bernese(University of Berne), GIPSY-OASIS(JPL), GAMIT(MIT). These software allow us to achieve millimeter accuracy in the horizontal position and about 1 cm accuracy vertically even for regional networks with a diameter of several thousand kilometers. But we established the standard of GPS data processing using Bernese as main tool and GIPSY O ASIS as side

  18. New BCJ representations for one-loop amplitudes in gauge theories and gravity

    Science.gov (United States)

    He, Song; Schlotterer, Oliver; Zhang, Yong

    2018-05-01

    We explain a procedure to manifest the Bern-Carrasco-Johansson duality between color and kinematics in n-point one-loop amplitudes of a variety of supersymmetric gauge theories. Explicit amplitude representations are constructed through a systematic reorganization of the integrands in the Cachazo-He-Yuan formalism. Our construction holds for any nonzero number of supersymmetries and does not depend on the number of spacetime dimensions. The cancellations from supersymmetry multiplets in the loop as well as the resulting power counting of loop momenta is manifested along the lines of the corresponding superstring computations. The setup is used to derive the one-loop version of the Kawai-Lewellen-Tye formula for the loop integrands of gravitational amplitudes.

  19. New Freedom through Medical Devices Based on the Global System for Mobile Communications: A Prospective Survey of 620 Users of the Swiss Limmex Emergency Wristwatch-An Original Study from Switzerland.

    Science.gov (United States)

    Tabbara, Malek; Ozgüler, Onur S; Exadaktylos, Aristomenis K

    2013-01-01

    About 500,000 elderly people in Switzerland suffer a fall each year. Thus medical attention and help are essential for these people, who mostly live alone without a caregiver. Only 3% of people aged over 65 in Switzerland use an emergency system. Personal telehealth devices allow patients to receive enough information about the appropriate treatment, as well as followup with their doctors and reports of any emergency, in the absence of any caregiver. This increases their quality of life in a cost-effective fashion. "Limmex"-a new medical emergency watch-was launched in Switzerland in 2011 and has been a great commercial success. In this paper, we give a brief review of this watch technology, along with the results of a survey of 620 users conducted by the Department of Emergency Medicine in Bern.

  20. Probabilistic disaggregation model with application to natural hazard risk assessment of portfolios

    DEFF Research Database (Denmark)

    Custer, Rocco; Nishijima, Kazuyoshi

    In natural hazard risk assessment, a resolution mismatch between hazard data and aggregated exposure data is often observed. A possible solution to this issue is the disaggregation of exposure data to match the spatial resolution of hazard data. Disaggregation models available in literature...... disaggregation model that considers the uncertainty in the disaggregation, taking basis in the scaled Dirichlet distribution. The proposed probabilistic disaggregation model is applied to a portfolio of residential buildings in the Canton Bern, Switzerland, subject to flood risk. Thereby, the model is verified...... are usually deterministic and make use of auxiliary indicator, such as land cover, to spatially distribute exposures. As the dependence between auxiliary indicator and disaggregated number of exposures is generally imperfect, uncertainty arises in disaggregation. This paper therefore proposes a probabilistic...

  1. Hubert Thüring, Corinna Jäger-Trees, Michael Schläfli (dir.), Anfangen zu schreiben. Ein kardinales Moment von Textgenese und Schreibprozess im literarischen Archiv des 20. Jahrhunderts [Commencer à écrire/Une

    OpenAIRE

    Hay, Louis

    2013-01-01

    On ne sait pas toujours en France que la Suisse aussi est terre de génétique. En Romandie, les chercheurs travaillent de longue date sur les archives littéraires fondées à Lausanne autour du fonds Ramuz. À Berne, le « Schweizerisches Literaturarchiv », créé à l’initiative de Dürrenmatt, a lancé un programme intitulé « Textgenese und Schreibprozess » auquel revient l’initiative du colloque de 2007 dont rend compte le présent volume de la collection « Zur Genealogie des Schreibens ». La rencont...

  2. Radiologic examination of orthopaedics. Methods and techniques

    International Nuclear Information System (INIS)

    Hafner, E.; Meuli, H.C.

    1976-01-01

    This volume describes in detail radiological examinations of the skeleton modern procedures in orthopaedic surgery. Special emphasis is given to functional examination techniques based upon the authors' extensive work on standardized radiological examinations best suited to the needs of orthopaedic surgeons. These techniques were developed at the Radiodiagnostic Department of the Central Radiological Clinic, Bern University, in cooperation with the University Clinic of Orthopaedics and Surgery of the Locomotor System. Exposure techniques are explained concisely, yet with extraordinary precision and attention to detail. They have proved highly successful in teaching programs for X-ray technicians and as standard examination techniques for many hospitals, X-ray departments, orthopaedic units, and private clinics. Recommended for orthopaedic surgeons, radiologists, general surgeons, and X-ray technicians, this definitive treatise, with its superb X-ray reproductions and complementary line drawings, explains how to achieve improved diagnoses and standardized control with the least possible radiation exposure to the patient

  3. Berends-Giele recursions and the BCJ duality in superspace and components

    Energy Technology Data Exchange (ETDEWEB)

    Mafra, Carlos R. [Institute for Advanced Study, School of Natural Sciences,Einstein Drive, Princeton, NJ 08540 (United States); DAMTP, University of Cambridge,Wilberforce Road, Cambridge, CB3 0WA (United Kingdom); Schlotterer, Oliver [Max-Planck-Institut für Gravitationsphysik, Albert-Einstein-Institut,Am Muehlenberg, 14476 Potsdam (Germany)

    2016-03-15

    The recursive method of Berends and Giele to compute tree-level gluon amplitudes is revisited using the framework of ten-dimensional super Yang-Mills. First, we prove that the pure spinor formula to compute SYM tree amplitudes derived in 2010 reduces to the standard Berends-Giele formula from the 80s when restricted to gluon amplitudes and additionally determine the fermionic completion. Second, using BRST cohomology manipulations in superspace, alternative representations of the component amplitudes are explored and the Bern-Carrasco-Johansson relations among partial tree amplitudes are derived in a novel way. Finally, it is shown how the supersymmetric components of manifestly local BCJ-satisfying tree-level numerators can be computed in a recursive fashion.

  4. An Overview of the International Congress on Whiplash Associated Disorders

    Directory of Open Access Journals (Sweden)

    Nikolai Bogduk

    2003-01-01

    Full Text Available Conferences such as the International Congress on Whiplash Associated Disorders, held in Berne on March 8-10, 2001, serve several purposes. Socially, they provide an opportunity for delegates to see, hear and meet leading experts in the field, and those experts get to meet one another. Academically, such conferences offer delegates a synopsis of current information, provided by plenary lectures, and the opportunity to hear or contribute new information, in the form of free papers. A measure of the success of such a conference is the extent to which new information presented advances knowledge and understanding in the field. This essay provides an overview of the congress at hand. It compares what was known before the congress with what more was known as a result of the congress.

  5. NATO Advanced Study Institute on Advances in the Computer Simulations of Liquid Crystals

    CERN Document Server

    Zannoni, Claudio

    2000-01-01

    Computer simulations provide an essential set of tools for understanding the macroscopic properties of liquid crystals and of their phase transitions in terms of molecular models. While simulations of liquid crystals are based on the same general Monte Carlo and molecular dynamics techniques as are used for other fluids, they present a number of specific problems and peculiarities connected to the intrinsic properties of these mesophases. The field of computer simulations of anisotropic fluids is interdisciplinary and is evolving very rapidly. The present volume covers a variety of techniques and model systems, from lattices to hard particle and Gay-Berne to atomistic, for thermotropics, lyotropics, and some biologically interesting liquid crystals. Contributions are written by an excellent panel of international lecturers and provides a timely account of the techniques and problems in the field.

  6. Public support for river restoration funding in relation to local river ecomorphology, population density, and mean income

    Science.gov (United States)

    SchläPfer, Felix; Witzig, Pieter-Jan

    2006-12-01

    In 1997, about 140,000 citizens in 388 voting districts in the Swiss canton of Bern passed a ballot initiative to allocate about 3 million Swiss Francs annually to a canton-wide river restoration program. Using the municipal voting returns and a detailed georeferenced data set on the ecomorphological status of the rivers, we estimate models of voter support in relation to local river ecomorphology, population density, mean income, cultural background, and recent flood damage. Support of the initiative increased with increasing population density and tended to increase with increasing mean income, in spite of progressive taxation. Furthermore, we found evidence that public support increased with decreasing "naturalness" of local rivers. The model estimates may be cautiously used to predict the public acceptance of similar restoration programs in comparable regions. Moreover, the voting-based insights into the distribution of river restoration benefits provide a useful starting point for debates about appropriate financing schemes.

  7. Oral voclosporin: novel calcineurin inhibitor for treatment of noninfectious uveitis

    Directory of Open Access Journals (Sweden)

    Roesel M

    2011-09-01

    Full Text Available Martin Roesel1, Christoph Tappeiner2, Arnd Heiligenhaus1,3, Carsten Heinz1,31Department of Ophthalmology, St Franziskus-Hospital, Muenster, Germany; 2Department of Ophthalmology, Inselspital, University of Bern, Switzerland; 3University Duisburg-Essen, GermanyAbstract: Voclosporin, a novel immunomodulatory drug inhibiting the calcineurin enzyme, was developed to prevent organ graft rejection and to treat autoimmune diseases. The chemical structure of voclosporin is similar to that of cyclosporine A, with a difference in one amino acid, leading to superior calcineurin inhibition and less variability in plasma concentration. Compared with placebo, voclosporin may significantly reduce inflammation and prevent recurrences of inflammation in patients with noninfectious uveitis. Future studies have to show if these advantages are accompanied by greater clinical efficacy and fewer side effects compared with the classic calcineurin inhibitors.Keywords: uveitis, immunosuppression, voclosporin

  8. Framing Light Rail Projects

    DEFF Research Database (Denmark)

    Olesen, Mette

    2014-01-01

    In Europe, there has been a strong political will to implement light rail. This article contributes to the knowledge concerning policies around light rail by analysing how local actors frame light rail projects and which rationalities and arguments are present in this decision-making process....... The article draws on the socio-technical approach to mobilities studies in order to reassemble the decision-making process in three European cases: Bergen, Angers, and Bern. This article provides insights into the political, discursive and material production of light rail mobilities in a European context....... It identifies the planning rationales behind the systems and the policies that have been supportive of this light rail vision. Finally, the article identifies the practical challenges and potentials that have been connected to the different local frames of light rail mobility which can be used in future...

  9. Preliminary Information on the Vertebrate Fauna (Animalia: Vertebrata of the NATURA2000 Site “Rice Fields Tsalapitsa” (Bulgaria

    Directory of Open Access Journals (Sweden)

    Ivayla L. Klimentova

    2011-12-01

    Full Text Available The study was carried out by tree visits in different areas of the Natura 2000 site “Rice Fields Tsalapitsa” BG 0002086 (West of Plovdiv city, near village of Tsalapitsa. Our preliminary research showed that in the area vertebrates with high conservation status occurred included in the Bulgarian Bidiversity Act, Appendix II and III, Appendix II of the Bern convention, Natura 2000 species list, the Bonn convention, Appendix II, the Convention of the International Trade of Endangered Species, and the list of the International Union for Conservation of the Nature. This information will help in future preparation of the management plan of the Natura 2000 site and showed the need of studies focused on such areas which will help undertaking adequate measures for their proper way of conservation.

  10. On a residual freedom of the next-to-leading BFKL eigenvalue in color adjoint representation in planar N=4 SYM

    Energy Technology Data Exchange (ETDEWEB)

    Bondarenko, Sergey; Prygarin, Alex [Physics Department, Ariel University,Ariel 40700, territories administered by (Israel)

    2016-07-15

    We discuss a residual freedom of the next-to-leading BFKL eigenvalue that originates from ambiguity in redistributing the next-to-leading (NLO) corrections between the adjoint BFKL eigenvalue and eigenfunctions in planar N=4 super-Yang-Mills (SYM) Theory. In terms of the remainder function of the Bern-Dixon-Smirnov (BDS) amplitude this freedom is translated to reshuffling correction between the eigenvalue and the impact factors in the multi-Regge kinematics (MRK) in the next-to-leading logarithm approximation (NLA). We show that the modified NLO BFKL eigenvalue suggested by the authors in ref. http://arxiv.org/abs/1510.00589 can be introduced in the MRK expression for the remainder function by shifting the anomalous dimension in the impact factor in such a way that the two and three loop remainder function is left unchanged to the NLA accuracy.

  11. Performances in a narrative by Sonia Coutinho

    Directory of Open Access Journals (Sweden)

    Caio Antônio de Medeiros Nóbrega Nunes Gomes

    2017-03-01

    Full Text Available In this article, we suggest the concepts of performance (Butler, 1990 and narrative performativity (Berns, 2013 as analytical tools for reflecting upon Toda Lana Turner tem seu Johnny Stompanato, a short story by the Brazilian writer Sonia Coutinho. A double movement will guide our analysis: we present an articulation between a perspective that takes into account the gender constitution of the characters and a narratological approach towards the reflexive/metafictional form which marks the composition of the short story. By making use of an ironical, intertextual and multi-layered style of writing, Sonia Coutinho constructs a narrative that proposes different discursive agencies in relation to the many instances in which characters’ subjectivities take place. In this sense, we consider this short story as having a deep mark of what we might understand as post-modern literature, for the multiplicity of spaces, characters and times is characteristic of a collective agency between reality and fiction.

  12. President of CERN Council discusses women in leadership

    CERN Multimedia

    Lidia Kleshchenko, IO-MBA student

    2015-01-01

    Agnieszka Zalewska, President of CERN Council, participated in the Annual High-Level Forum “Women in Leadership”, which took place on 29 April in Geneva. The event was organised by a group of students participating in the International Organizations MBA (IO-MBA) programme at the University of Geneva, which has maintained a friendly relationship with CERN since its creation.   From left to right: Ambassador Suzan LeVine, Prof. Doris Schopper and Prof. Agnieszka Zalewska. (Image: Lidia Kleshchenko.) The forum gathered influential leaders from Geneva, Bern, Rome and Krakow to discuss the perceptions, challenges and opportunities that women face in leading roles in international organisations. The panellists were Irene Khan, Director-General of the International Development Law Organization, Suzan LeVine, United States Ambassador to Switzerland and Liechtenstein, Michael Møller, United Nations Under-Secretary-General and Acting Director-General of the United Nation...

  13. The mechanics of anaphase B in a basidiomycete as revealed by laser microbeam microsurgery

    International Nuclear Information System (INIS)

    Bayles, C.J.; Aist, J.R.; Berns, M.W.

    1993-01-01

    Bayles, C. J., Aist, J. R., and Berns, M. W. 1993. The mechanics of anaphase B in a basidiomycete as revealed by laser microbeam microsurgery. Experimental Mycology 17, 191-199. Cytoplasmic forces were found to be actively pulling on the spindle pole bodies during anaphase B in the dikaryotic, basidiomycete fungus, Helicobasidium mompa. When the spindle of one nucleus was severed with a laser microbeam at mid anaphase B, its two spindle pole bodies separated at a much faster rate than did those of the intact spindle in the other nucleus of the same cell. Since astral microtubule populations apparently reach their maximum during anaphase B in this fungus, we suggest that these microtubules may be involved in the cytoplasmic pulling forces. The spindle appears to act primarily as a governor, regulating the rate at which the spindle pole bodies are separated

  14. The energy roof - Photovoltaics and solar collectors combined; PV und Kollektoren schoen kombiniert. Das Energiedach

    Energy Technology Data Exchange (ETDEWEB)

    Niederhaeusern, A.

    2008-07-01

    In this Interview with Giorgio Hefti, CEO of the Swiss Tritec group, the company's aims and the products offered are discussed. These include mains-connected and island-operated photovoltaic (PV) systems. The history of the company is briefly discussed, as is co-operation with local installers and the company's function as a general contractor for large installations. These include, amongst others, the PV-installation on the 'Stade de Suisse' football stadium in Berne. PV systems for single-family homes and their costs are examined. Also, mounting systems for combining PV and solar collectors (combined power and heat generation) are discussed, as are combinations of PV and heat-pumps. Hybrid PV-solar-collectors and their disadvantages are discussed as is the future of the Tritec group, which has grown continuously over the years and is active in several European countries.

  15. LOW ENDOPHTHALMITIS RATES AFTER INTRAVITREAL ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR INJECTIONS IN AN OPERATION ROOM

    DEFF Research Database (Denmark)

    Freiberg, Florentina J; Brynskov, Troels; Munk, Marion R

    2017-01-01

    PURPOSE: To evaluate the rate of presumed endophthalmitis (EO) after intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections in three European hospitals performed in an operation room (OR) under sterile conditions. METHODS: A retrospective multicenter study between 2003 and 2016...... at three European sites, City Hospital Triemli Zurich, Switzerland (CHT), Zealand University Hospital Roskilde, Denmark (ZUH) and University Clinic Bern, Switzerland (UCB). Intravitreal injection (IVI) database of each department was reviewed. All anti-vascular endothelial growth factor injections were...... performed using a standardized sterile technique in an operation room. Injection protocols were similar between the three sites. No preinjection antibiotics were given. Postoperative antibiotics varied among sites. RESULTS: A total of 134,701 intravitreal injections were performed at the 3 sites between...

  16. Towards Understanding the Climate of Venus Applications of Terrestrial Models to Our Sister Planet

    CERN Document Server

    Bonnet, Roger-Maurice; Grinspoon, David; Koumoutsaris, Symeon; Lebonnois, Sebastien; Titov, Dmitri

    2013-01-01

    ESA’s Venus Express Mission has monitored Venus since April 2006, and scientists worldwide have used mathematical models to investigate its atmosphere and model its circulation. This book summarizes recent work to explore and understand the climate of the planet through a research program under the auspices of the International Space Science Institute (ISSI) in Bern, Switzerland. Some of the unique elements that are discussed are the anomalies with Venus’ surface temperature (the huge greenhouse effect causes the surface to rise to 460°C, without which would plummet as low as -40°C), its unusual lack of solar radiation (despite being closer to the Sun, Venus receives less solar radiation than Earth due to its dense cloud cover reflecting 76% back) and the juxtaposition of its atmosphere and planetary rotation (wind speeds can climb up to 200 m/s, much faster than Venus’ sidereal day of 243 Earth-days).

  17. Expansion of all multitrace tree level EYM amplitudes

    Science.gov (United States)

    Du, Yi-Jian; Feng, Bo; Teng, Fei

    2017-12-01

    In this paper, we investigate the expansion of tree level multitrace Einstein-Yang-Mills (EYM) amplitudes. First, we propose two types of recursive expansions of tree level EYM amplitudes with an arbitrary number of gluons, gravitons and traces by those amplitudes with fewer traces or/and gravitons. Then we give many support evidence, including proofs using the Cachazo-He-Yuan (CHY) formula and Britto-Cachazo-Feng-Witten (BCFW) recursive relation. As a byproduct, two types of generalized BCJ relations for multitrace EYM are further proposed, which will be useful in the BCFW proof. After one applies the recursive expansions repeatedly, any multitrace EYM amplitudes can be given in the Kleiss-Kuijf (KK) basis of tree level color ordered Yang-Mills (YM) amplitudes. Thus the Bern-Carrasco-Johansson (BCJ) numerators, as the expansion coefficients, for all multitrace EYM amplitudes are naturally constructed.

  18. CERN physicist receives Einstein Medal

    CERN Multimedia

    2006-01-01

    On 29 June the CERN theorist Gabriele Veneziano was awarded the prestigious Albert Einstein Medal for significant contributions to the understanding of string theory. This award is given by the Albert Einstein Society in Bern to individuals whose scientific contributions relate to the work of Einstein. Former recipients include exceptional physicists such as Murray Gell-Mann last year, but also Stephen Hawking and Victor Weisskopf. Gabriele Veneziano, a member of the integrated CERN Theory Team since 1977, led the Theory Division from 1994 to 1997 and has already received many prestigious prizes for his outstanding work, including the Enrico Fermi Prize (see CERN Courier, November 2005), the Dannie Heineman Prize for mathematical physics of the American Physical Society in 2004 (see Bulletin No. 47/2003), and the I. Ya. Pomeranchuk Prize of the Institute of Theoretical and Experimental Physics (Moscow) in 1999.

  19. CERN Library | Edoardo Amaldi presents "The adventurous life of Friedrich Georg Houtermans, physicist (1903-1966)" | 11 November

    CERN Multimedia

    2014-01-01

    The physicist Friedrich Houtermans (1903-1966) was an important promoter and proponent of the development of physics in Berne. He introduced a number of activities in the field of elementary particles, with a special focus on the physics of cosmic rays, and made important contributions in applied physics.   This biography of Houtermans was written by Edoardo Amaldi and was almost finished just before his unexpected death in 1989. The editors have only corrected typographical errors and introduced minimal text changes in order to preserve the original content. Additionally they have collected and included previously unpublished pictures and memories from Houtermans’ students and collaborators.  The text is the result of a thorough and intensive study of Houtermans’ life and character carried out by Edoardo Amaldi. It is more than a biography, since the figure of Houtermans is set in a historical period in Europe between the two world wars. This book will be of great i...

  20. The adventurous life of Friedrich Georg Houtermans, physicist (1903-1966)

    CERN Document Server

    Braccini, Saverio; Ereditato, Antonio; Scampoli, Paola

    2012-01-01

    The physicist Friedrich Houtermans (1903-1966) was an essential promoter and proponent of the development of physics in Berne. He introduced a number of activities in the field of elementary particles, with a special focus on the physics of cosmic rays, and important contributions in applied physics. This biography of Houtermans was written by Edoardo Amaldi and was almost finished just before his unexpected death in 1989. The editors have only corrected typographical errors and have introduced only minimal text changes in order to preserve the original content. Additionally they have collected and included unpublished pictures and memories from Houtermans’ students and collaborators. The text is the result of a thorough and intensive study on Houtermans’ life and character carried out by Edoardo Amaldi. It is more than a biography, since the figure of Houtermans is set in a historical perspective of Europe between the two world wars. This book will be of great interest to historians and historians of sci...

  1. The Linked Neighbour List (LNL) method for fast off-lattice Monte Carlo simulations of fluids

    Science.gov (United States)

    Mazzeo, M. D.; Ricci, M.; Zannoni, C.

    2010-03-01

    We present a new algorithm, called linked neighbour list (LNL), useful to substantially speed up off-lattice Monte Carlo simulations of fluids by avoiding the computation of the molecular energy before every attempted move. We introduce a few variants of the LNL method targeted to minimise memory footprint or augment memory coherence and cache utilisation. Additionally, we present a few algorithms which drastically accelerate neighbour finding. We test our methods on the simulation of a dense off-lattice Gay-Berne fluid subjected to periodic boundary conditions observing a speedup factor of about 2.5 with respect to a well-coded implementation based on a conventional link-cell. We provide several implementation details of the different key data structures and algorithms used in this work.

  2. Patient-reported outcomes instruments: bridging the gap between international copyright laws and common practice for developers and users--a case example.

    Science.gov (United States)

    Anfray, Caroline

    2009-12-01

    Copyright laws are intended to protect the rights of authors in their literary, scientific, and artistic works. The recent controversy about the standardized version of the Asthma Quality of Life Questionnaire between Elizabeth Juniper and Eirini Grammatopoulou et al. is an example of the difficulties inherent to copyright faced by developers and users of patient-reported outcome (PRO) instruments. This brief communication presents the basics of international copyright laws (i.e., the Berne Convention), the facts behind the controversy, and our analysis of the case based on our experience as a distributing center of PRO instruments. We conclude that better communication between developers and users would prevent most unfortunate complications and misunderstandings.

  3. Fabiola Gianotti, the newly elected Spokesperson of ATLAS

    CERN Multimedia

    2008-01-01

    On 11 July Fabiola Gianotti was elected by the ATLAS Collaboration as its future Spokesperson. Her term of office will start on 1 March 2009 and will last for two years. She will take over from Peter Jenni who has been ATLAS Spokesperson since its formalization in 1992. Three distinguished physicists stood as candidates for this election: Fabiola Gianotti (CERN), Marzio Nessi (CERN), and Leonardo Rossi (INFN Genova, Italy). The nomination process started on 30 October 2007, with a general email sent to the ATLAS collaboration calling for nominations, and closed on 25 January 2008. Any ATLAS physicist could nominate a candidate, and 24 nominees were proposed before the ATLAS search committee narrowed them to the final three. After the voting process, which concluded the ATLAS general meeting in Bern, the Collaboration Board greeted the result with warm applause.

  4. Non-linear gauge transformations in D=10 SYM theory and the BCJ duality

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Seungjin [Max-Planck-Institut für Gravitationsphysik Albert-Einstein-Institut,14476 Potsdam (Germany); Mafra, Carlos R. [Institute for Advanced Study, School of Natural Sciences,Einstein Drive, Princeton, NJ 08540 (United States); DAMTP, University of Cambridge,Wilberforce Road, Cambridge, CB3 0WA (United Kingdom); Schlotterer, Oliver [Max-Planck-Institut für Gravitationsphysik Albert-Einstein-Institut,14476 Potsdam (Germany)

    2016-03-14

    Recent progress on scattering amplitudes in super Yang-Mills and superstring theory benefitted from the use of multiparticle superfields. They universally capture tree-level subdiagrams, and their generating series solve the non-linear equations of ten-dimensional super Yang-Mills. We provide simplified recursions for multiparticle superfields and relate them to earlier representations through non-linear gauge transformations of their generating series. Moreover, we discuss the gauge transformations which enforce their Lie symmetries as suggested by the Bern-Carrasco-Johansson duality between color and kinematics. Another gauge transformation due to Harnad and Shnider is shown to streamline the theta-expansion of multiparticle superfields, bypassing the need to use their recursion relations beyond the lowest components. The findings of this work tremendously simplify the component extraction from kinematic factors in pure spinor superspace.

  5. Measurement of antiproton annihilation on Cu, Ag and Au with emulsion films

    International Nuclear Information System (INIS)

    Aghion, S.; Consolati, G.; Evans, C.; Ferragut, R.; Amsler, C.; Ariga, A.; Ariga, T.; Ereditato, A.; Bonomi, G.; Bräunig, P.; Demetrio, A.; Brusa, R.S.; Cabaret, L.; Comparat, D.; Caccia, M.; Castelli, F.; Caravita, R.; Noto, L. Di; Cerchiari, G.; Doser, M.

    2017-01-01

    The characteristics of low energy antiproton annihilations on nuclei (e.g. hadronization and product multiplicities) are not well known, and Monte Carlo simulation packages that use different models provide different descriptions of the annihilation events. In this study, we measured the particle multiplicities resulting from antiproton annihilations on nuclei. The results were compared with predictions obtained using different models in the simulation tools GEANT4 and FLUKA. For this study, we exposed thin targets (Cu, Ag and Au) to a very low energy antiproton beam from CERN's Antiproton Decelerator, exploiting the secondary beamline available in the AEgIS experimental zone. The antiproton annihilation products were detected using emulsion films developed at the Laboratory of High Energy Physics in Bern, where they were analysed at the automatic microscope facility. The fragment multiplicity measured in this study is in good agreement with results obtained with FLUKA simulations for both minimally and heavily ionizing particles.

  6. Measurement of antiproton annihilation on Cu, Ag and Au with emulsion films

    Science.gov (United States)

    Aghion, S.; Amsler, C.; Ariga, A.; Ariga, T.; Bonomi, G.; Bräunig, P.; Brusa, R. S.; Cabaret, L.; Caccia, M.; Caravita, R.; Castelli, F.; Cerchiari, G.; Comparat, D.; Consolati, G.; Demetrio, A.; Di Noto, L.; Doser, M.; Ereditato, A.; Evans, C.; Ferragut, R.; Fesel, J.; Fontana, A.; Gerber, S.; Giammarchi, M.; Gligorova, A.; Guatieri, F.; Haider, S.; Hinterberger, A.; Holmestad, H.; Huse, T.; Kawada, J.; Kellerbauer, A.; Kimura, M.; Krasnický, D.; Lagomarsino, V.; Lansonneur, P.; Lebrun, P.; Malbrunot, C.; Mariazzi, S.; Matveev, V.; Mazzotta, Z.; Müller, S. R.; Nebbia, G.; Nedelec, P.; Oberthaler, M.; Pacifico, N.; Pagano, D.; Penasa, L.; Petracek, V.; Pistillo, C.; Prelz, F.; Prevedelli, M.; Ravelli, L.; Rienaecker, B.; RØhne, O. M.; Rotondi, A.; Sacerdoti, M.; Sandaker, H.; Santoro, R.; Scampoli, P.; Simon, M.; Smestad, L.; Sorrentino, F.; Testera, G.; Tietje, I. C.; Vamosi, S.; Vladymyrov, M.; Widmann, E.; Yzombard, P.; Zimmer, C.; Zmeskal, J.; Zurlo, N.

    2017-04-01

    The characteristics of low energy antiproton annihilations on nuclei (e.g. hadronization and product multiplicities) are not well known, and Monte Carlo simulation packages that use different models provide different descriptions of the annihilation events. In this study, we measured the particle multiplicities resulting from antiproton annihilations on nuclei. The results were compared with predictions obtained using different models in the simulation tools GEANT4 and FLUKA. For this study, we exposed thin targets (Cu, Ag and Au) to a very low energy antiproton beam from CERN's Antiproton Decelerator, exploiting the secondary beamline available in the AEgIS experimental zone. The antiproton annihilation products were detected using emulsion films developed at the Laboratory of High Energy Physics in Bern, where they were analysed at the automatic microscope facility. The fragment multiplicity measured in this study is in good agreement with results obtained with FLUKA simulations for both minimally and heavily ionizing particles.

  7. District heating in Flensburg

    Energy Technology Data Exchange (ETDEWEB)

    Prinz, W.

    1981-01-01

    The majority of our population, but also of our authorities, are still skeptical or even disapproving towards district heating. The reasons of this negative attitude are partly psychological - e.g. the individualism of the Swiss and their dislike for too centralised structures and ''forced connections'' - but also the existence of finished gas supply networks and the fear of considerable pre-investments and torn streets over years. The following article - held as a speech on the information meeting ''District heating and the possible contribution of nuclear energy'' organised by the Swiss Association for Atomic Energy in Bern shows a practical problem solving at the example of the district heating in Flensburg and deals with these questions.

  8. [Jakob Klaesi on his 120th birthday].

    Science.gov (United States)

    Haenel, T

    2003-05-01

    Jakob Klaesi was born on the 29th May 1883 in Glarus Canton (Switzerland) and was assistant and later head physician at the Psychiatric University Hospital in Zurich, directed by Eugen Bleuler. Klaesi directed the new Psychiatric Outpatient Department in Basel from 1923 to 1926 and later founded the Schloss Kronau private clinic in the Zurich Canton. In 1933 he became director of the Psychiatric University Hospital in Bern. His attitude toward somatic treatment methods was skeptical, although about 1920 he founded a psychiatric sleep cure with Somnifen. Klaesi was primarily a psychotherapist and interested in the psychodynamics of his patients. With his great empathy, he was able to understand especially well their expressive behaviour. This capacity for empathy and his philosophic orientation enabled him to develop a phenomenological analysis of expression. He died on the 17th August 1980. Differences and parallels to the thinking of Alfred Adler and Karl Jaspers are discussed.

  9. Earlier surgery improves outcomes from painful chronic pancreatitis

    Science.gov (United States)

    Ke, Nengwen; Jia, Dan; Huang, Wei; Nunes, Quentin M.; Windsor, John A.; Liu, Xubao; Sutton, Robert

    2018-01-01

    Abstract The timing of surgery for painful chronic pancreatitis (CP) may affect outcomes. Clinical course, Izbicki pain scores, and pancreatic function were retrospectively compared and analyzed between patients undergoing either early or late surgery (pancreatic mass +/− ductal dilatation (47% vs 27%, P insufficiency (60% vs 72%, P = .034); there were no other significant differences. The early group had longer hospital stay (14.4 vs 12.2 days, P = .009), but no difference in complications. Significantly greater pain relief followed early surgery (complete 69% vs 47%, partial 22% vs 37%, none 8% vs 16%, P = .01) with lower rates of exocrine (60% vs 80%, P = .005) and endocrine insufficiency (36% vs 53%, P = .033). Our data indicate that early surgery results in higher rates of pain relief and pancreatic sufficiency than late surgery for chronic pancreatitis patients. Frey and Berne procedures showed better results than other surgical procedures. PMID:29742705

  10. Cross-calibration of far UV spectra of solar system objects and the heliosphere

    CERN Document Server

    Snow, Martin; Bonnet, Roger-Maurice

    2013-01-01

    This book is the result of a working group sponsored by ISSI in Bern, which was initially created to study possible ways to calibrate a Far Ultraviolet (FUV) instrument after launch. In most cases, ultraviolet instruments are well calibrated on the ground, but unfortunately, optics and detectors in the FUV are very sensitive to contaminants and it is very challenging to prevent contamination before and during the test and launch sequences of a space mission. Therefore, ground calibrations need to be confirmed after launch and it is necessary to keep track of the temporal evolution of the sensitivity of the instrument during the mission. The studies presented here cover various fields of FUV spectroscopy with the exclusion of direct solar UV spectroscopy, including a catalog of stellar spectra, data-sets of lunar Irradiance, observations of comets and measurements of the interplanetary background. Detailed modeling of the interplanetary background is presented as well. This work also includes comparisons of ol...

  11. The Difficult Diagnosis of Ischaemic Papillary Muscle Rupture; Case report from an urban emergency department

    Directory of Open Access Journals (Sweden)

    Christian T. Braun

    2016-05-01

    Full Text Available We present a rare case of severe ischaemic papillary muscle rupture in a 67-year-old male patient who was admitted to the Emergency Department of the University Hospital Bern, Switzerland, in November 2013 with acute chest pain. On admission, the patient’s blood pressure was 60/40 mm/Hg, his pulse was 110 beats per minute and his respiratory rate was 20 breaths per minute. An electrocardiogram was normal and focused assessment with sonography in trauma was negative. Transthoracic echocardiography showed possible thickening of the mitral valve leaflet with no indications of severe mitral insufficiency or wall motion abnormalities. Triple-ruleout computed tomography angiography revealed no pulmonary emboli or aortic dissection, although coronary atherosclerosis was present. Finally, severe insufficiency of the mitral valve with rupture of the papillary muscle, likely due to ischaemia, was observed via transoesophageal echocardiography. The patient underwent a successful surgical intervention and was discharged 10 days later in stable condition.

  12. New Freedom through Medical Devices Based on the Global System for Mobile Communications: A Prospective Survey of 620 Users of the Swiss Limmex Emergency Wristwatch—An Original Study from Switzerland

    Directory of Open Access Journals (Sweden)

    Malek Tabbara

    2013-01-01

    Full Text Available About 500,000 elderly people in Switzerland suffer a fall each year. Thus medical attention and help are essential for these people, who mostly live alone without a caregiver. Only 3% of people aged over 65 in Switzerland use an emergency system. Personal telehealth devices allow patients to receive enough information about the appropriate treatment, as well as followup with their doctors and reports of any emergency, in the absence of any caregiver. This increases their quality of life in a cost-effective fashion. “Limmex”—a new medical emergency watch—was launched in Switzerland in 2011 and has been a great commercial success. In this paper, we give a brief review of this watch technology, along with the results of a survey of 620 users conducted by the Department of Emergency Medicine in Bern.

  13. Dams release methane even in temperate zoned

    International Nuclear Information System (INIS)

    Lemarchand, F.

    2010-01-01

    The Wohlen lake (near Bern) is a retaining dam built 90 years ago that has undergone a campaign to measure the quantity of methane released. The campaign lasted 1 year and the result was unexpected: 0.15 g/m 2 *day which one of the highest release rates in temperate zones. This result is all the more stunning since water stays only 2 days in average in the reservoir and that the drowned area is not important. In fact the river Aar that feeds the lake is loaded with organic matter coming from humane activities: agriculture and 3 sewage plants. This organic matter decays in the lake releasing methane. (A.C.)

  14. Symposium on Decoherence and No-Signalling : Current Interpretational Problems of Quantum Theory

    CERN Document Server

    Wüthrich, Adrian; New vistas on old problems : recent approaches to the foundations of quantum mechanics

    2017-01-01

    Quantum theory has been a subject of interpretational debates ever since its inception. The Einstein-Podolsky-Rosen paradox, the empirical violation of Bell's inequalities, and recent activities to exploit quantum entanglement for technological innovation only exacerbate a long-standing philosophical debate. Despite no-signaling theorems and theories of decoherence, deep- rooted conflicts between special relativistic principles and observed quantum correlations as well as between definite measurement outcomes and quantum theoretical superpositions persist. This collection of papers, first presented at an international symposium at the University of Bern in 2011, highlights some recent approaches to the old problems of a philosophy of quantum mechanics. The authors address the issues from a variety of perspectives, ranging from variations of causal theory and system theoretic interpretations of the observer to an empirical test of whether entanglement itself can be entangled. The essays demonstrate that the di...

  15. [The drug abuse patient as emergency].

    Science.gov (United States)

    Kessler, R; Ryser, D H

    1991-01-15

    Acute drug intoxication is a medical emergency considering its potential interference with vital functions. All 157 cases with drug overdose admitted to the emergency department of the "Inselspital" in Berne over 183 days between July 1989 and June 1990 were analyzed retrospectively. In the vast majority of cases heroin overdose was involved. In mixed poisonings with heroin mostly flunitrazepam and alcohol contributed to the clinical picture, less commonly cocaine. There were very few intoxications with cocaine alone. A practical approach to the management of patients with certain or suspected drug intoxication presenting with coma and depressed respiration is proposed. In the therapy of acute intoxications with opiates and benzodiazepines there are specific antagonists available. In contrast, therapy of cocaine overdose remains symptomatic. The medical complications of acute heroin and cocaine intoxications are discussed separately.

  16. LED; Zum Thema LED

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    This collection of articles on the subject of light emitting diodes (LED) provides technical information on LED technology, examines latest developments and provides examples of LED use in practice. An 'ABC' of LED technology is presented and fifteen common LED mistakes are noted. The chances and risks of LED use are discussed as is the retrofitting of lighting installations with LEDs. The use of LEDs in street lighting is examined. The journal also includes interviews with architects and a lighting designer. Practical examples of the use of LEDs include the refurbished parliamentary library in Berne, their use in the bird sanctuary headquarters in Sempach, Switzerland, as well as LED use in sales outlets. Also, the use of LED lighting in a spa gazebo in Lucerne is examined.

  17. Size-dependent accumulation of particles in lysosomes modulates dendritic cell function through impaired antigen degradation

    Directory of Open Access Journals (Sweden)

    Seydoux E

    2014-08-01

    Full Text Available Emilie Seydoux,1,2 Barbara Rothen-Rutishauser,1,3 Izabela M Nita,1 Sandor Balog,3 Amiq Gazdhar,1 Philip A Stumbles,4,5 Alke Petri-Fink,3,6 Fabian Blank,1,* Christophe von Garnier1,*1Department of Respiratory Medicine, Inselspital, Bern University Hospital, Department of Clinical Research, University of Bern, 2Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland; 3Adolphe Merkle Institute, University of Fribourg, Fribourg, Switzerland; 4School of Veterinary and Life Sciences, Molecular and Biomedical Sciences, Murdoch University, Perth, WA, Australia; 5Telethon Kids Institute, Perth, WA, Australia; 6Department of Chemistry, University of Fribourg, Fribourg, Switzerland*These authors contributed equally to the manuscriptIntroduction: Nanosized particles may enable therapeutic modulation of immune responses by targeting dendritic cell (DC networks in accessible organs such as the lung. To date, however, the effects of nanoparticles on DC function and downstream immune responses remain poorly understood. Methods: Bone marrow–derived DCs (BMDCs were exposed in vitro to 20 or 1,000 nm polystyrene (PS particles. Particle uptake kinetics, cell surface marker expression, soluble protein antigen uptake and degradation, as well as in vitro CD4+ T-cell proliferation and cytokine production were analyzed by flow cytometry. In addition, co-localization of particles within the lysosomal compartment, lysosomal permeability, and endoplasmic reticulum stress were analyzed. Results: The frequency of PS particle–positive CD11c+/CD11b+ BMDCs reached an early plateau after 20 minutes and was significantly higher for 20 nm than for 1,000 nm PS particles at all time-points analyzed. PS particles did not alter cell viability or modify expression of the surface markers CD11b, CD11c, MHC class II, CD40, and CD86. Although particle exposure did not modulate antigen uptake, 20 nm PS particles decreased the capacity

  18. CERN’s Rugby Club to play the Swiss Cup semi-finals: come and support the CERN team!

    CERN Multimedia

    2011-01-01

    On Saturday 25 June, the CERN’s Rugby Club will be playing in the Swiss Cup semi-final against the Hermance Rugby Club. Although the CERN club has had a less than stellar year in the Swiss national first division, they earned a place in the Cup semi-final after beating Bern 30 – 0 and La Chaux-de-Fonds 38 – 7. The club last made it to the Swiss Cup semi-finals in 2002, where they lost to Hermance (the most successful Swiss rugby club, followed closely by CERN’s). Show your support for the CERN team and help them reach the Swiss Cup final by going to the 25 June match at 15.00 in the CERN pitch.  

  19. Social positions, scripts, and functioning dynamics: phenomenology of the Egyptian social unconscious.

    Science.gov (United States)

    Taha, Mohamed

    2014-07-01

    This article explores the constituents, components, and manifestations of the Egyptian social unconscious. Noting that Bion's group basic assumptions are actually based on Klein's individual psychic positions (Paranoid-Schizoid and Depressive; PS-D), and can easily be extrapolated to the social large group, the author assumes that to communities, societies, and cultures the same assumptions may apply to some extent. Moreover, just as groups can move between basic assumption functioning and work functioning, so societies seem to do. Eric Berne's concept of an "individual life script" can also be extended to societies that can have a "social life script." This article is a step toward designing a "social unconscious" map for different countries and cultures that shows where on the PS-D spectrum a certain country is placed, what is a certain culture's "social life script," and how the dynamics of a certain society can be manifested in its people's behavior as either basic assumption or work functioning.

  20. Berends-Giele recursions and the BCJ duality in superspace and components

    International Nuclear Information System (INIS)

    Mafra, Carlos R.; Schlotterer, Oliver

    2016-01-01

    The recursive method of Berends and Giele to compute tree-level gluon amplitudes is revisited using the framework of ten-dimensional super Yang-Mills. First, we prove that the pure spinor formula to compute SYM tree amplitudes derived in 2010 reduces to the standard Berends-Giele formula from the 80s when restricted to gluon amplitudes and additionally determine the fermionic completion. Second, using BRST cohomology manipulations in superspace, alternative representations of the component amplitudes are explored and the Bern-Carrasco-Johansson relations among partial tree amplitudes are derived in a novel way. Finally, it is shown how the supersymmetric components of manifestly local BCJ-satisfying tree-level numerators can be computed in a recursive fashion.