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Sample records for igpro20 csl bern

  1. Peripatetic Highlights in Bern

    Science.gov (United States)

    Hentschel, Ann M.

    The capital city of the Swiss Canton of Bern and of the Swiss Confederation is nestled in a narrow loop of the Aare river, at the foot of the Alps. The old town, founded around 1191, is well preserved despite a devastating fire in 1405.** Major industries of the region developed under the constraints of modest domestic markets, high transportation costs, and protectionist legislation across national borders. Switzerland thus found its niche in higher-end markets, such as chocolate making, engine building, instruments, fine textiles, and chemicals or pharmaceuticals. My tour past historically significant scientific sites in Bern will use the local legacy of its most illustrious residents, Albert Einstein (1879-1955), who lived there from 1902-1909, and Fritz Houtermans (1903-1966), who lived there from 1952-1966, as its guiding thread through the old town and the university district. Place names in italics mark stops along the tour.

  2. Mobile Seamless Technology Enhanced CSL Oral Communication

    Science.gov (United States)

    Lan, Yu-Ju; Lin, Yen-Ting

    2016-01-01

    The current study aimed at investigating how mobile seamless technology can be used to enhance the pragmatic competence of learners of Chinese as a second language (CSL). 34 overseas CSL learners participated in this study. They were randomly assigned into two groups: the classroom group, executing language tasks in fake contexts in a traditional…

  3. Mobile Seamless Technology Enhanced CSL Oral Communication

    Science.gov (United States)

    Lan, Yu-Ju; Lin, Yen-Ting

    2016-01-01

    The current study aimed at investigating how mobile seamless technology can be used to enhance the pragmatic competence of learners of Chinese as a second language (CSL). 34 overseas CSL learners participated in this study. They were randomly assigned into two groups: the classroom group, executing language tasks in fake contexts in a traditional…

  4. Efficient CSL Model Checking Using Stratification

    DEFF Research Database (Denmark)

    Zhang, Lijun; Jansen, David N.; Nielson, Flemming;

    2012-01-01

    For continuous-time Markov chains, the model-checking problem with respect to continuous-time stochastic logic (CSL) has been introduced and shown to be decidable by Aziz, Sanwal, Singhal and Brayton in 1996 [ 1, 2]. Their proof can be turned into an approximation algorithm with worse than expone...

  5. Automata-Based CSL Model Checking

    DEFF Research Database (Denmark)

    Zhang, Lijun; Jansen, David N.; Nielson, Flemming;

    2011-01-01

    For continuous-time Markov chains, the model-checking problem with respect to continuous-time stochastic logic (CSL) has been introduced and shown to be decidable by Aziz, Sanwal, Singhal and Brayton in 1996. The presented decision procedure, however, has exponential complexity. In this paper, we...

  6. Thermodynamic and structural insights into CSL-DNA complexes

    Energy Technology Data Exchange (ETDEWEB)

    Friedmann, David R.; Kovall, Rhett A. (UCIN-MED)

    2010-10-28

    The Notch pathway is an intercellular signaling mechanism that plays important roles in cell fates decisions throughout the developing and adult organism. Extracellular complexation of Notch receptors with ligands ultimately results in changes in gene expression, which is regulated by the nuclear effector of the pathway, CSL (C-promoter binding factor 1 (CBF-1), suppressor of hairless (Su(H)), lin-12 and glp-1 (Lag-1)). CSL is a DNA binding protein that is involved in both repression and activation of transcription from genes that are responsive to Notch signaling. One well-characterized Notch target gene is hairy and enhancer of split-1 (HES-1), which is regulated by a promoter element consisting of two CSL binding sites oriented in a head-to-head arrangement. Although previous studies have identified in vivo and consensus binding sites for CSL, and crystal structures of these complexes have been determined, to date, a quantitative description of the energetics that underlie CSL-DNA binding is unknown. Here, we provide a thermodynamic and structural analysis of the interaction between CSL and the two individual sites that comprise the HES-1 promoter element. Our comprehensive studies that analyze binding as a function of temperature, salt, and pH reveal moderate, but distinct, differences in the affinities of CSL for the two HES-1 binding sites. Similarly, our structural results indicate that overall CSL binds both DNA sites in a similar manner; however, minor changes are observed in both the conformation of CSL and DNA. Taken together, our results provide a quantitative and biophysical basis for understanding how CSL interacts with DNA sites in vivo.

  7. Emergence of inflationary perturbations in the CSL model

    Energy Technology Data Exchange (ETDEWEB)

    Leon, Gabriel [Universidad de Buenos Aires, Ciudad Universitaria-PabI, Departamento de Fisica, Facultad de Ciencias Exactas y Naturales, Buenos Aires (Argentina); Bengochea, Gabriel R. [Instituto de Astronomia y Fisica del Espacio (IAFE), UBA-CONICET, Buenos Aires (Argentina)

    2016-01-15

    The inflationary paradigm is the most successful model that explains the observed spectrum of primordial perturbations. However, the precise emergence of such inhomogeneities and the quantum-to-classical transition of the perturbations has not yet reached a consensus among the community. The continuous spontaneous localization model (CSL), in the cosmological context, might be used to provide a solution to the mentioned issues by considering a dynamical reduction of the wave function. The CSL model has been applied to the inflationary universe before and different conclusions have been obtained. In this letter, we use a different approach to implement the CSL model during inflation. In particular, in addition to accounting for the quantum-to-classical transition, we use the CSL model to generate the primordial perturbations, that is, the dynamical evolution provided by the CSL model is responsible for the transition from a homogeneous and isotropic initial state to a final one lacking such symmetries. Our approach leads to results that can be clearly distinguished from preceding works. Specifically, the scalar and tensor power spectra are not time-dependent, and one retains the amplification mechanism of the CSL model. Moreover, our framework depends only on one parameter (the CSL parameter) and its value is consistent with cosmological and laboratory observations. (orig.)

  8. Fission yeast CSL proteins function as transcription factors.

    Directory of Open Access Journals (Sweden)

    Martina Oravcová

    Full Text Available BACKGROUND: Transcription factors of the CSL (CBF1/RBP-Jk/Suppressor of Hairless/LAG-1 family are key regulators of metazoan development and function as the effector components of the Notch receptor signalling pathway implicated in various cell fate decisions. CSL proteins recognize specifically the GTG[G/A]AA sequence motif and several mutants compromised in their ability to bind DNA have been reported. In our previous studies we have identified a number of novel putative CSL family members in fungi, organisms lacking the Notch pathway. It is not clear whether these represent genuine CSL family members. METHODOLOGY/PRINCIPAL FINDINGS: Using a combination of in vitro and in vivo approaches we characterized the DNA binding properties of Cbf11 and Cbf12, the antagonistic CSL paralogs from the fission yeast, important for the proper coordination of cell cycle events and the regulation of cell adhesion. We have shown that a mutation of a conserved arginine residue abolishes DNA binding in both CSL paralogs, similar to the situation in mouse. We have also demonstrated the ability of Cbf11 and Cbf12 to activate gene expression in an autologous fission yeast reporter system. CONCLUSIONS/SIGNIFICANCE: Our results indicate that the fission yeast CSL proteins are indeed genuine family members capable of functioning as transcription factors, and provide support for the ancient evolutionary origin of this important protein family.

  9. ON FINITE RANK OPERATORS IN CSL ALGEBRAS Ⅲ

    Institute of Scientific and Technical Information of China (English)

    ChenPeixin; LuShijie; TaoChangli

    2002-01-01

    In terms of the exactly nonzero partition,the reducible projection-system and correlation matrices, two characterizations for a rank three operator in a CSL algebra can be completely decomposed are given.

  10. Dynamics of the Gay-Berne fluid

    Energy Technology Data Exchange (ETDEWEB)

    de Miguel, E.; Rull, L.F. (Departamento de Fisica Atomica, Molecular y Nuclear, Universidad de Sevilla, Apartado 1065, Sevilla 41080 (Spain)); Gubbins, K.E. (School of Chemical Engineering, Cornell University, Ithaca, New York 14853 (United States))

    1992-03-15

    Using molecular-dynamics computer simulation, we study the dynamical behavior of the isotropic and nematic phases of highly anisotropic molecular fluids. The interactions are modeled by means of the Gay-Berne potential with anisotropy parameters {kappa}=3 and {kappa}{prime}=5. The linear-velocity autocorrelation function shows no evidence of a negative region in the isotropic phase, even at the higher densities considered. The self-diffusion coefficient parallel to the molecular axis shows an anomalous increase with density as the system enters the nematic region. This enhancement in parallel diffusion is also observed in the isotropic side of the transition as a precursor effect. The molecular reorientation is discussed in the light of different theoretical models. The Debye diffusion model appears to explain the reorientational mechanism in the nematic phase. None of the models gives a satisfactory account of the reorientation process in the isotropic phase.

  11. 75 FR 54024 - Drawbridge Operation Regulation; Trent River, New Bern, NC

    Science.gov (United States)

    2010-09-03

    ... water. On behalf of the National Multiple Sclerosis (MS) Society and the City of New Bern NC, the North... Bern Ride and the City of New Bern Heritage Parade. Under this deviation, the drawbridge would be..., 2010 and Sunday, September 12, 2010, respectively; and for the City of New Bern Heritage Parade from...

  12. Bern clothes washer study. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Tomlinson, J.J.; Rizy, D.T.

    1998-03-01

    The US market for domestic clothes washers is currently dominated by conventional, vertical axis washers, which typically require about 40 gallons of water for each load. Although small for an individual load, the fact that 35 billion loads of laundry are washed annually in the US results in a substantial quantity of water and energy use. Although much smaller, today`s market for high-efficiency clothes washers which use much less water and energy is growing albeit slowly as manufacturers are making washers based around tumble-action, horizontal axis designs available, information about their performance and benefits is being developed, and consumers are made aware of these benefits. To help build awareness of these benefits and to accelerate markets for high-efficiency washers, DOE, under its Energy Star Program and in cooperation with Maytag Appliances, conducted a field-evaluation of high-efficiency washers using Bern, Kansas (population approximately 200) as a test bed. Baseline washer performance data as well as customer washing behavior were obtained from data collected on the existing washers of more than 100 participants in this instrumented study. Following a 2-month initial study period, all conventional washers were replaced by high-efficiency, tumble action washers, and the experiment continued for another 3-month period. Based on measured data from over 20,000 loads of laundry, the impact of the washer replacement on (1) individual customers` energy and water consumption, (2) customers` laundry habits and perceptions, and (3) the community`s water supply and waste water systems were determined and reported.

  13. Loss of CSL Unlocks a Hypoxic Response and Enhanced Tumor Growth Potential in Breast Cancer Cells

    Directory of Open Access Journals (Sweden)

    Eike-Benjamin Braune

    2016-05-01

    Full Text Available Notch signaling is an important regulator of stem cell differentiation. All canonical Notch signaling is transmitted through the DNA-binding protein CSL, and hyperactivated Notch signaling is associated with tumor development; thus it may be anticipated that CSL deficiency should reduce tumor growth. In contrast, we report that genetic removal of CSL in breast tumor cells caused accelerated growth of xenografted tumors. Loss of CSL unleashed a hypoxic response during normoxic conditions, manifested by stabilization of the HIF1α protein and acquisition of a polyploid giant-cell, cancer stem cell-like, phenotype. At the transcriptome level, loss of CSL upregulated more than 1,750 genes and less than 3% of those genes were part of the Notch transcriptional signature. Collectively, this suggests that CSL exerts functions beyond serving as the central node in the Notch signaling cascade and reveals a role for CSL in tumorigenesis and regulation of the cellular hypoxic response.

  14. Geometrical theory of triple junctions of CSL boundaries.

    Science.gov (United States)

    Gertsman, V Y

    2001-07-01

    When three grain boundaries having misorientations generating coincidence site lattices (CSLs) meet at a triple junction, a common (triple-junction) CSL is formed. A theory is developed as a set of theorems establishing the relationships between the geometrical parameters of the grain-boundary and triple-junction CSLs. Application of the theory is demonstrated in detail for the case of the cubic crystal system. It is also shown how the theory can be extended to an arbitrary crystal lattice.

  15. CSL grain boundary distribution in alumina and zirconia ceramics

    OpenAIRE

    Vonlanthen, Pierre; Grobéty, Bernard

    2008-01-01

    The distributions of general and coincidence site lattice (CSL) grain boundaries (GBs) in texture-free alumina and zirconia ceramics sintered at two different temperatures were investigated based on electron backscatter diffraction (EBSD) measurements. Results were compared with the distributions obtained from random 2D spatial models and with calculated random distributions reported in the literature. All alumina samples independent on sintering temperature show the same characteristic devia...

  16. Antibodies to Berne virus in horses and other animals

    NARCIS (Netherlands)

    Horzinek, M.C.; Weiss, Marianne; Steck, F.; Kaderli, R.

    1984-01-01

    After inoculation into 2 foals, Berne virus induced neutralizing antibody, but did not cause clinical symptoms. In a horizontal study of seropositive mares and their offspring, a decline of maternal antibodies and a sudden synchronous seroconversion in all foals were observed, again without clinical

  17. Antibodies to Berne virus in horses and other animals

    NARCIS (Netherlands)

    Horzinek, M.C.; Weiss, Marianne; Steck, F.; Kaderli, R.

    1984-01-01

    After inoculation into 2 foals, Berne virus induced neutralizing antibody, but did not cause clinical symptoms. In a horizontal study of seropositive mares and their offspring, a decline of maternal antibodies and a sudden synchronous seroconversion in all foals were observed, again without clinical

  18. International Congress on Whiplash Associated Disorders - The Bern Symposium

    Directory of Open Access Journals (Sweden)

    Harold Merskey

    2003-01-01

    Full Text Available We take pleasure in this issue in presenting a series of plenary session lectures and some additional contributions from the Bern Symposium, a meeting held in Berne, Switzerland from March 8 to 10, 2001. The symposium was organized by Dr Bogdan Radanov and colleagues from that city where they had themselves undertaken an enormous amount of classical work in the investigation of cervical sprain syndrome. Radanov's work resolved a number of definitive issues in the investigation of whiplash, despite those who say otherwise for medicolegal reasons. He and his colleagues showed clearly that pain after cervical sprain injury was primarily correlated with the intensity of the initial pain, with the occurrence of premorbid injury and with age. Personality status before injury had no bearing on the outcome, and the intensity of pain at the beginning of injury was also correlated with depression or cognitive change later (1.

  19. Oral-Performance Language Tasks for CSL Beginners in Second Life

    Science.gov (United States)

    Lan, Yu-Ju; Kan, Yu-Hsuan; Sung, Yao-Ting; Chang, Kuo-En

    2016-01-01

    The aim of this study was to determine the effects of different types of language tasks performed in Second Life (SL) on the oral performance of beginners of Chinese as a Second Language (CSL), focusing on oral accuracy. The 30 CSL beginners who participated in this study were randomly divided into two groups (n = 15 per group), required to…

  20. Crystalline roof glazing - Westside shopping centre, Berne; Kristalline Dachverglasungen

    Energy Technology Data Exchange (ETDEWEB)

    Enkerli, W.

    2009-07-01

    This illustrated article takes a look at the new shopping and leisure centre on the western outskirts of Berne, Switzerland. In particular, the roof of this unusual building over the motorway with its sloping walls and zig-zag design is looked at. The centre's shopping mall, adventure baths and spa, a multiplex cinema, an old peoples' home and a hotel are briefly discussed, as is the embedding of the centre in its suburban environment. The roof construction with its crystalline skylights is examined and discussed in detail. The centre's building technical services are also briefly commented on.

  1. Abortive lytic reactivation of KSHV in CBF1/CSL deficient human B cell lines.

    Directory of Open Access Journals (Sweden)

    Barbara A Scholz

    Full Text Available Since Kaposi's sarcoma associated herpesvirus (KSHV establishes a persistent infection in human B cells, B cells are a critical compartment for viral pathogenesis. RTA, the replication and transcription activator of KSHV, can either directly bind to DNA or use cellular DNA binding factors including CBF1/CSL as DNA adaptors. In addition, the viral factors LANA1 and vIRF4 are known to bind to CBF1/CSL and modulate RTA activity. To analyze the contribution of CBF1/CSL to reactivation in human B cells, we have successfully infected DG75 and DG75 CBF1/CSL knock-out cell lines with recombinant KSHV.219 and selected for viral maintenance by selective medium. Both lines maintained the virus irrespective of their CBF1/CSL status. Viral reactivation could be initiated in both B cell lines but viral genome replication was attenuated in CBF1/CSL deficient lines, which also failed to produce detectable levels of infectious virus. Induction of immediate early, early and late viral genes was impaired in CBF1/CSL deficient cells at multiple stages of the reactivation process but could be restored to wild-type levels by reintroduction of CBF1/CSL. To identify additional viral RTA target genes, which are directly controlled by CBF1/CSL, we analyzed promoters of a selected subset of viral genes. We show that the induction of the late viral genes ORF29a and ORF65 by RTA is strongly enhanced by CBF1/CSL. Orthologs of ORF29a in other herpesviruses are part of the terminase complex required for viral packaging. ORF65 encodes the small capsid protein essential for capsid shell assembly. Our study demonstrates for the first time that in human B cells viral replication can be initiated in the absence of CBF1/CSL but the reactivation process is severely attenuated at all stages and does not lead to virion production. Thus, CBF1/CSL acts as a global hub which is used by the virus to coordinate the lytic cascade.

  2. Shear viscosity of binary mixtures: The Gay-Berne potential

    Energy Technology Data Exchange (ETDEWEB)

    Khordad, R., E-mail: khordad@mail.yu.ac.ir [Department of Physics, College of Sciences, Yasouj University, Yasouj 75914-353 (Iran, Islamic Republic of)

    2012-05-25

    Highlights: Black-Right-Pointing-Pointer Most useful potential model to study the real systems is the Gay-Berne (GB) potential. Black-Right-Pointing-Pointer We use GB model to examine thermodynamical properties of some anisotropic binary mixtures in two different phases. Black-Right-Pointing-Pointer The integral equation methods are applied to solve numerically the Percus-Yevick (PY) equation. Black-Right-Pointing-Pointer We obtain expansion coefficients of correlation functions needed to calculate the properties of studied mixtures. Black-Right-Pointing-Pointer The results are compared with the available experimental data [e.g., HFC-125 + propane, R-125/143a, methanol + toluene, etc.] - Abstract: The Gay-Berne (GB) potential model is an interesting and useful model to study the real systems. Using the potential model, we intend to examine the thermodynamical properties of some anisotropic binary mixtures in two different phases, liquid and gas. For this purpose, we apply the integral equation method and solve numerically the Percus-Yevick (PY) integral equation. Then, we obtain the expansion coefficients of correlation functions to calculate the thermodynamical properties. Finally, we compare our results with the available experimental data [e.g., HFC-125 + propane, R-125/143a, methanol + toluene, benzene + methanol, cyclohexane + ethanol, benzene + ethanol, carbon tetrachloride + ethyl acetate, and methanol + ethanol]. The results show that the GB potential model is capable for predicting the thermodynamical properties of binary mixtures with acceptable accuracy.

  3. The cyclotron laboratory and the RFQ accelerator in Bern

    Science.gov (United States)

    Braccini, S.; Ereditato, A.; Kreslo, I.; Nirkko, M.; Scampoli, P.; von Bremen, K.; Weber, M.

    2013-07-01

    Two proton accelerators have been recently put in operation in Bern: an 18 MeV cyclotron and a 2 MeV RFQ linac. The commercial IBA 18/18 cyclotron, equipped with a specifically conceived 6 m long external beam line ending in a separate bunker, will provide beams for routine 18-F and other PET radioisotope production as well as for novel detector, radiation biophysics, radioprotection, radiochemistry and radiopharmacy developments. The accelerator is embedded into a complex building hosting two physics laboratories and four Good Manufacturing Practice (GMP) laboratories. This project is the result of a successful collaboration between the Inselspital, the University of Bern and private investors, aiming at the constitution of a combined medical and research centre able to provide the most cutting-edge technologies in medical imaging and cancer radiation therapy. The cyclotron is complemented by the RFQ with the primary goals of elemental analysis via Particle Induced Gamma Emission (PIGE), and the detection of potentially dangerous materials with high nitrogen content using the Gamma-Resonant Nuclear Absorption (GRNA) technique. In this context, beam instrumentation devices have been developed, in particular an innovative beam profile monitor based on doped silica fibres and a setup for emittance measurements using the pepper-pot technique. On this basis, the establishment of a proton therapy centre on the campus of the Inselspital is in the phase of advanced study.

  4. The cyclotron laboratory and the RFQ accelerator in Bern

    Energy Technology Data Exchange (ETDEWEB)

    Braccini, S.; Ereditato, A.; Kreslo, I.; Nirkko, M.; Weber, M. [Albert Einstein Center for Fundamental Physics, Laboratory for High Energy Physics (LHEP), University of Bern, Sidlerstrasse 5, CH-3012 Bern (Switzerland); Scampoli, P. [Albert Einstein Center for Fundamental Physics, Laboratory for High Energy Physics (LHEP), University of Bern, Sidlerstrasse 5, CH-3012 Bern, Switzerland and Department of Physical Sciences, University Federico II, Via Cintia, I-60126 Napoli (Italy); Bremen, K. von [SWAN Isotopen AG, Inselspital, CH-3010 Bern (Switzerland)

    2013-07-18

    Two proton accelerators have been recently put in operation in Bern: an 18 MeV cyclotron and a 2 MeV RFQ linac. The commercial IBA 18/18 cyclotron, equipped with a specifically conceived 6 m long external beam line ending in a separate bunker, will provide beams for routine 18-F and other PET radioisotope production as well as for novel detector, radiation biophysics, radioprotection, radiochemistry and radiopharmacy developments. The accelerator is embedded into a complex building hosting two physics laboratories and four Good Manufacturing Practice (GMP) laboratories. This project is the result of a successful collaboration between the Inselspital, the University of Bern and private investors, aiming at the constitution of a combined medical and research centre able to provide the most cutting-edge technologies in medical imaging and cancer radiation therapy. The cyclotron is complemented by the RFQ with the primary goals of elemental analysis via Particle Induced Gamma Emission (PIGE), and the detection of potentially dangerous materials with high nitrogen content using the Gamma-Resonant Nuclear Absorption (GRNA) technique. In this context, beam instrumentation devices have been developed, in particular an innovative beam profile monitor based on doped silica fibres and a setup for emittance measurements using the pepper-pot technique. On this basis, the establishment of a proton therapy centre on the campus of the Inselspital is in the phase of advanced study.

  5. Effects of Lactobacillus acidophilus D2/CSL on laying hen performance

    National Research Council Canada - National Science Library

    Luigi Guidobono Cavalchini; Carla Orsi; Viviana Ferrazzi; Stefano Marelli; Maria Grazia Mangiagalli; Alberto Giardini; Daniele Gallazzi

    2010-01-01

    In order to evaluate the effects of dietary addition of probiotic strain Lactobacillus acidophilus D2/CSL on hen performance and egg quality, 160 commercial Hy-Line Brown pullets, 17 weeks old, were...

  6. Role of CSL-dependent and independent Notch signaling pathways in cell apoptosis.

    Science.gov (United States)

    Zeng, Chong; Xing, Rui; Liu, Jing; Xing, Feiyue

    2016-01-01

    Apoptosis is a normally biological phenomenon in various organisms, involving complexly molecular mechanisms with a series of signaling processes. Notch signaling is found evolutionarily conserved in many species, playing a critical role in embryonic development, normal tissue homeostasis, angiogenesis and immunoregulation. The focus of this review is on currently novel advances about roles of CSL-dependent and independent Notch signaling pathways in cell apoptosis. The CSL can bind Notch intracellular domain (NIC) to act as a switch in mediating transcriptional activation or inactivation of the Notch signaling pathway downstream genes in the nucleus. It shows that CSL-dependent signaling regulates the cell apoptosis through Hes-1-PTEN-AKT-mTOR signaling, but rather the CSL-independent signaling mediates the cell apoptosis possibly via NIC-mTORC2-AKT-mTOR signaling, providing a new insight into apoptotic mechanisms.

  7. Single-flavor CSL phase in compact stars

    CERN Document Server

    Blaschke, D; Klahn, T; Berdermann, J

    2008-01-01

    We suggest a scenario where the three light quark flavors are sequentially deconfined under increasing pressure in cold asymmetric nuclear matter as e.g. in neutron stars. The basis for our analysis is a chiral quark matter model of Nambu--Jona-Lasinio (NJL) type with diquark pairing in the spin-1 single flavor (CSL), spin-0 two flavor (2SC) and three flavor (CFL) channels. We find that nucleon dissociation sets in at about the saturation density, n_0, when the down-quark Fermi sea is populated (d-quark dripline) due to the flavor asymmetry induced by beta-equilibrium and charge neutrality. At about 3n_0 u-quarks appear and a two-flavor color superconducting (2SC) phase is formed. The s-quark Fermi sea is populated only at still higher baryon density, when the quark chemical potential is of the order of the dynamically generated strange quark mass. We construct two different hybrid equations of state (EoS) using the Dirac-Brueckner Hartree-Fock (DBHF) approach and the EoS by Shen et al in the nuclear matter s...

  8. Expression profiling and integrative analysis of the CESA/CSL superfamily in rice

    Directory of Open Access Journals (Sweden)

    Tu Yuanyuan

    2010-12-01

    Full Text Available Abstract Background The cellulose synthase and cellulose synthase-like gene superfamily (CESA/CSL is proposed to encode enzymes for cellulose and non-cellulosic matrix polysaccharide synthesis in plants. Although the rice (Oryza sativa L. genome has been sequenced for a few years, the global expression profiling patterns and functions of the OsCESA/CSL superfamily remain largely unknown. Results A total of 45 identified members of OsCESA/CSL were classified into two clusters based on phylogeny and motif constitution. Duplication events contributed largely to the expansion of this superfamily, with Cluster I and II mainly attributed to tandem and segmental duplication, respectively. With microarray data of 33 tissue samples covering the entire life cycle of rice, fairly high OsCESA gene expression and rather variable OsCSL expression were observed. While some members from each CSL family (A1, C9, D2, E1, F6 and H1 were expressed in all tissues examined, many of OsCSL genes were expressed in specific tissues (stamen and radicles. The expression pattern of OsCESA/CSL and OsBC1L which extensively co-expressed with OsCESA/CSL can be divided into three major groups with ten subgroups, each showing a distinct co-expression in tissues representing typically distinct cell wall constitutions. In particular, OsCESA1, -3 & -8 and OsCESA4, -7 & -9 were strongly co-expressed in tissues typical of primary and secondary cell walls, suggesting that they form as a cellulose synthase complex; these results are similar to the findings in Arabidopsis. OsCESA5/OsCESA6 is likely partially redundant with OsCESA3 for OsCESA complex organization in the specific tissues (plumule and radicle. Moreover, the phylogenetic comparison in rice, Arabidopsis and other species can provide clues for the prediction of orthologous gene expression patterns. Conclusions The study characterized the CESA/CSL of rice using an integrated approach comprised of phylogeny, transcriptional

  9. ??? - Bern 1935 - Tartu 1995 : [Protokolõ sionskihh mudretsov] / Kristiina Ross ; ter.: Majana Abramson

    Index Scriptorium Estoniae

    Ross, Kristiina

    1996-01-01

    Sisu: Tartu 1995; 'Protokolõ' kak takovõje; Original 'Protokolov'; Predõstorija sozdanija mifa o pokorenii mira jevrejami - volnõmi kamenshtshikami; 'Protokolõ' v ideologitsheskom hodu; 'Protokolõ' i natsism; Bern 1935-1937

  10. ??? - Bern 1935 - Tartu 1995 : [Protokolõ sionskihh mudretsov] / Kristiina Ross ; ter.: Majana Abramson

    Index Scriptorium Estoniae

    Ross, Kristiina

    1996-01-01

    Sisu: Tartu 1995; 'Protokolõ' kak takovõje; Original 'Protokolov'; Predõstorija sozdanija mifa o pokorenii mira jevrejami - volnõmi kamenshtshikami; 'Protokolõ' v ideologitsheskom hodu; 'Protokolõ' i natsism; Bern 1935-1937

  11. In Bern high-energy physics shares proton beams with the hospital

    CERN Multimedia

    CERN Bulletin

    2011-01-01

    A joint venture bringing together public institutions and private companies is building a new facility on the campus of Inselspital, Bern’s university hospital. The facility will host a cyclotron for the production of radiopharmaceuticals for use in PET as well as in multidisciplinary research laboratories for the development of new products for medical imaging. The Laboratory for High Energy Physics (LHEP) of Bern University, which is deeply involved in the project, will have access to a dedicated beam line and specialized labs.     Construction of the new facility is ongoing at Bern's University Hospital, where the cyclotron will be installed.   The first Bern Cyclotron symposium will take place on 6 and 7 June this year. The event is being organised by LHEP in collaboration with Bern’s Inselspital and will bring together experts – including several from CERN – to promote research activities at the new Bern Cyclotron Laboratory. &ld...

  12. Virtual Visit to the ATLAS Control Room by the University of Bern

    CERN Multimedia

    ATLAS Experiment

    2012-01-01

    Fresher's day for potential future bachelor students Infotage für Studieninteressierte Bachelor Once a year the University of Bern organizes two information days for young potential future bachelor students. Young aspiring candidates interested in a career in physics will be shown the forefront of physics research, where a trip around the university physics laboratories, and a direct video link to the ATLAS Control room at CERN's Large Hadron Collider is part of the program. A physicist from Bern will present directly from the ATLAS control room for a direct and personal view into the physics at the LHC, the Higgs particle, the generation of mass, antimatter, the origin of the universe and the involvement of the Bern high-energy physics team in the ATLAS experiment. This also allows for fruitful discussions about their own perspectives of perhaps becoming a CERN physicist one day. http://atlas-live-virtual-visit.web.cern.ch/atlas-live-virtual-visit/2012/Bern-2012.html

  13. Hydrophobic solvation of Gay-Berne particles in modified water models

    Science.gov (United States)

    Head-Gordon, Teresa; Lynden-Bell, Ruth M.

    2008-03-01

    The solvation of large hydrophobic solutes, modeled as repulsive and attractive Gay-Berne oblate ellipsoids, is characterized in several modified water liquids using the SPC/E model as the reference water fluid. We find that small amounts of attraction between the Gay-Berne particle and any model fluid result in wetting of the hydrophobic surface. However, significant differences are found among the modified and SPC/E water models and the critical distances in which they dewet the hydrophobic surfaces of pairs of repulsive Gay-Berne particles. We find that the dewetting trends for repulsive Gay-Berne particles in the various model liquids correlate directly with their surface tensions, the widths of the interfaces they form, and the openness of their network structure. The largest critical separations are found in liquids with the smallest surface tensions and the broadest interfaces as measured by the Egelstaff-Widom length.

  14. The Structure of the Bern-Kosower Integrand for the N-Gluon Amplitude

    CERN Document Server

    Schubert, C

    1998-01-01

    An ambiguity inherent in the partial integration procedure leading to the Bern-Kosower rules is fixed in a way which preserves the complete permutation symmetry in the scattering states. This leads to a canonical version of the Bern-Kosower representation for the one-loop N - photon/gluon amplitudes, and to a natural decomposition of those amplitudes into permutation symmetric gauge invariant partial amplitudes. This decomposition exhibits a simple recursive structure.

  15. Fractionation in Gay-Berne liquid crystal mixtures.

    Science.gov (United States)

    Moreno-Razo, J Antonio; Díaz-Herrera, Enrique; Klapp, Sabine H L

    2007-10-01

    We present a constant-pressure molecular dynamics simulation study of the phase behavior of binary (50:50) Gay-Berne liquid crystal mixtures consisting of elongated particles with different lengths (LA>LB) and equal diameters. We focus on systems at dense liquid-state conditions. Considering three mixtures characterized by different values of LA(B) and different length ratios q=LB/LA<1, we find complex fluid-fluid phase behavior resulting from the interplay between nematic, smectic-A-type, or smectic-B-type orientational ordering, on the one hand, and demixing into two phases of different composition (fractionation), on the other hand. The driving "forces" of demixing transitions are the temperature and the length ratio. Indeed, in the system characterized by the largest value of q (q=0.86) orientational order occurs already in mixed states, whereas full fractionation is found at q=0.71. The two resulting states are either of type smectic-B-nematic (intermediate temperatures) or smectic-B-smectic-B (low temperatures). In the intermediate case q=0.80 we observe a stepwise ordering and demixing behavior on cooling the system from high temperatures. Moreover, our results show that the stability range of (partially) nematic structures in mixtures of sufficiently small q can be significantly larger than in the pure counterparts, in qualitative agreement with experimental observations.

  16. Effects of Lactobacillus acidophilus D2/CSL on laying hen performance

    OpenAIRE

    Luigi Guidobono Cavalchini; Carla Orsi; Viviana Ferrazzi; Stefano Marelli; Maria Grazia Mangiagalli; Alberto Giardini; Daniele Gallazzi

    2010-01-01

    In order to evaluate the effects of dietary addition of probiotic strain Lactobacillus acidophilus D2/CSL on hen performance and egg quality, 160 commercial Hy-Line Brown pullets, 17 weeks old, were divided in control group (C) (N=80) and treated group (T) (N=80), with 4 alternate replicates of 20 animals each per group. C was fed with a “standard diet”, whereas the T group received the same diet with an inclusion of 1x109 CFU kg-1 of Lactobacillus acidophilus D2/CSL (freeze dried...

  17. The Graduate School of Climate Sciences, University of Bern

    Science.gov (United States)

    Martin, L.

    2012-04-01

    The Graduate School of Climate Sciences, University of Bern, offers a specialised M.Sc. and a Ph.D. study programme in climate sciences. The graduate school has a highly interdisciplinary profile involving not only natural sciences, but also humanities/history, economics and law. The ten participating institutes with a total of 45 academics provide expertise in long-term climate variability, climate modelling, climate reconstruction, predictability of the future climate and extreme events, the impact of climate change on ecosystems and climate risks for society and economy. The graduate school is fully compliant with the Bologna Accords and collaborates closely with the sister institution C2SM at ETH Zurich by, e.g., jointly organised lectures. There are currently 23 master and 37 doctoral students in the programme. These originate from the University of Bern (28 %), from other Swiss universities (30 %) and from foreign universities (42 %). Comprehensive information about the Graduate School of Climate Sciences is available at http://www.climatestudies.unibe.ch . The M.Sc. in Climate Sciences programme (120 ECTS credits) is designed to attract students from all disciplines in natural sciences and offers them a tailor-made curriculum to reach their career aspirations. The students make their own course selection according to their profile envisaged (specialised versus broad education) and ideally already guided by a job perspective. Selecting the courses and the topic of the master thesis they specialise in one of five fields: climate and earth system science; atmospheric science; economics; economic, social and environmental history; statistics. Several courses are organised jointly with public authorities and the private industry, e.g. from experts working in the insurance business, in weather forecasting or in environmental pollution control. This provides the students hands-on experience and contacts to future employers. The master thesis (60 ECTS) involves the

  18. Quasi-matter bounce and inflation in the light of the CSL model

    CERN Document Server

    Leon, Gabriel; Landau, Susana J

    2016-01-01

    The Continuous Spontaneous Localization (CSL) model has been proposed as a possible solution to the quantum measurement problem by modifying the Schr\\"{o}dinger equation. In this work, we apply the CSL model to two cosmological models of the early Universe: the matter bounce scenario and slow roll inflation. In particular, we focus on the generation of the classical primordial inhomogeneities and anisotropies that arise from the dynamical evolution, provided by the CSL mechanism, of the quantum state associated to the quantum fields. In each case, we obtained a prediction for the shape and the parameters characterizing the primordial spectra (scalar and tensor), i.e. the amplitude, the spectral index and the tensor-to-scalar ratio. We found that there exist CSL parameter values, allowed by other non-cosmological experiments, for which our predictions for the angular power spectrum of the CMB temperature anisotropy are consistent with the best fit canonical model to the latest data released by the Planck Colla...

  19. Evaluating CSL/CFL Website Usability: A User-Centered Design Approach

    Science.gov (United States)

    Huang, Chung-Kai; Hsin, Ching-O; Chiu, Chiung-Hui

    2010-01-01

    With the widespread availability of Internet and computer technology, on-line web-based learning has become prevalent in the field of teaching Chinese as a second/foreign language (CSL/CFL). This study examined the concepts of usability and types of design elements that help construct an effective web-based learning environment, as well as their…

  20. CSL protein regulates transcription of genes required to prevent catastrophic mitosis in fission yeast.

    Science.gov (United States)

    Převorovský, Martin; Oravcová, Martina; Zach, Róbert; Jordáková, Anna; Bähler, Jürg; Půta, František; Folk, Petr

    2016-11-16

    For every eukaryotic cell to grow and divide, intricately coordinated action of numerous proteins is required to ensure proper cell-cycle progression. The fission yeast Schizosaccharomyces pombe has been instrumental in elucidating the fundamental principles of cell-cycle control. Mutations in S. pombe 'cut' (cell untimely torn) genes cause failed coordination between cell and nuclear division, resulting in catastrophic mitosis. Deletion of cbf11, a fission yeast CSL transcription factor gene, triggers a 'cut' phenotype, but the precise role of Cbf11 in promoting mitotic fidelity is not known. We report that Cbf11 directly activates the transcription of the acetyl-coenzyme A carboxylase gene cut6, and the biotin uptake/biosynthesis genes vht1 and bio2, with the former 2 implicated in mitotic fidelity. Cbf11 binds to a canonical, metazoan-like CSL response element (GTGGGAA) in the cut6 promoter. Expression of Cbf11 target genes shows apparent oscillations during the cell cycle using temperature-sensitive cdc25-22 and cdc10-M17 block-release experiments, but not with other synchronization methods. The penetrance of catastrophic mitosis in cbf11 and cut6 mutants is nutrient-dependent. We also show that drastic decrease in biotin availability arrests cell proliferation but does not cause mitotic defects. Taken together, our results raise the possibility that CSL proteins play conserved roles in regulating cell-cycle progression, and they could guide experiments into mitotic CSL functions in mammals.

  1. Investigation into the temperature dependence of isotropic- nematic phase transition of Gay- Berne liquid crystals

    Directory of Open Access Journals (Sweden)

    A Avazpour

    2014-12-01

    Full Text Available Density functional approach was used to study the isotropic- nematic (I-N transition and calculate the values of freezing parameters of the Gay- Berne liquid crystal model. New direct and pair correlation functions of a molecular fluid with Gay- Berne pair potential were used. These new functions were used in density functional theory as input to calculate the isotropic- nematic transition densities for elongation at various reduced temperatures. It was observed that the isotropic- nematic transition densities increase as the temperature increases. It was found that the new direct correlation function is suitable to study the isotropic- nematic transition of Gay- Berne liquids. Comparison to other works showed qualitative agreement

  2. Enhanced HDL Functionality in Small HDL Species Produced Upon Remodeling of HDL by Reconstituted HDL, CSL112

    Science.gov (United States)

    Didichenko, Svetlana A.; Navdaev, Alexei V.; Cukier, Alexandre M.O.; Gille, Andreas; Schuetz, Patrick; Spycher, Martin O.; Thérond, Patrice; Chapman, M. John; Kontush, Anatol

    2016-01-01

    Rationale: CSL112, human apolipoprotein A-I (apoA-I) reconstituted with phosphatidylcholine, is known to cause a dramatic rise in small high-density lipoprotein (HDL). Objective: To explore the mechanisms by which the formation of small HDL particles is induced by CSL112. Methods and Results: Infusion of CSL112 into humans caused elevation of 2 small diameter HDL fractions and 1 large diameter fraction. Ex vivo studies showed that this remodeling does not depend on lipid transfer proteins or lipases. Rather, interaction of CSL112 with purified HDL spontaneously gave rise to 3 HDL species: a large, spherical species composed of apoA-I from native HDL and CSL112; a small, disc-shaped species composed of apoA-I from CSL112, but smaller because of the loss of phospholipids; and the smallest species, lipid-poor apoA-I composed of apoA-I from HDL and CSL112. Time-course studies suggest that remodeling occurs by an initial fusion of CSL112 with HDL and subsequent fission leading to the smaller forms. Functional studies showed that ATP-binding cassette transporter 1–dependent cholesterol efflux and anti-inflammatory effects in whole blood were carried by the 2 small species with little activity in the large species. In contrast, the ability to inactivate lipid hydroperoxides in oxidized low-density lipoprotein was carried predominantly by the 2 largest species and was low in lipid-poor apoA-I. Conclusions: We have described a mechanism for the formation of small, highly functional HDL species involving spontaneous fusion of discoidal HDL with spherical HDL and subsequent fission. Similar remodeling is likely to occur during the life cycle of apoA-I in vivo. PMID:27436846

  3. Exact Combinatorics of Bern-Kosower-type Amplitudes for Two-Loop $\\Phi^{3}$ Theory

    CERN Document Server

    Sato, H T; Sato, Haru-Tada; Schmidt, Michael G.

    1998-01-01

    Counting the contribution rate of a world-line formula to Feynman diagrams in Bern-Kosower-like amplitudes derived from a bosonic string theory for $N$-point two-loop Feynman amplitudes. In this connection we also present a method to derive simple and compact world-line forms for the effective action.

  4. Randomized trial to compare the safety and immunogenicity of CSL Limited's 2009 trivalent inactivated influenza vaccine to an established vaccine in United States children.

    Science.gov (United States)

    Brady, Rebecca C; Hu, Wilson; Houchin, Vonda G; Eder, Frank S; Jackson, Kenneth C; Hartel, Gunter F; Sawlwin, Daphne C; Albano, Frank R; Greenberg, Michael

    2014-12-12

    A trivalent inactivated influenza vaccine (CSL's TIV, CSL Limited) was licensed under USA accelerated approval regulations for use in persons≥18 years. We performed a randomized, observer-blind study to assess the safety and immunogenicity of CSL's TIV versus an established US-licensed vaccine in a population≥6 months to loss of appetite (for Cohort A) and malaise (for Cohort B) were also significantly higher for CSL's TIV compared to the established vaccine. Post-vaccination geometric mean titers (GMTs) for CSL's TIV versus the established vaccine were 385.49 vs. 382.45 for H1N1; 669.13 vs. 705.61 for H3N2; and 100.65 vs. 93.72 for B. CSL's TIV demonstrated immunological non-inferiority to the established vaccine in all cohorts.

  5. Cbf11 and Cbf12, the fission yeast CSL proteins, play opposing roles in cell adhesion and coordination of cell and nuclear division

    Energy Technology Data Exchange (ETDEWEB)

    Prevorovsky, Martin; Grousl, Tomas; Stanurova, Jana; Rynes, Jan [Department of Cell Biology, Faculty of Science, Charles University in Prague, Vinicna 7, 128 43, Prague 2 (Czech Republic); Nellen, Wolfgang [Department of Genetics, Kassel University, Heinrich Plett Strasse 40, 34132 Kassel (Germany); Puta, Frantisek [Department of Cell Biology, Faculty of Science, Charles University in Prague, Vinicna 7, 128 43, Prague 2 (Czech Republic); Folk, Petr, E-mail: folk@natur.cuni.cz [Department of Cell Biology, Faculty of Science, Charles University in Prague, Vinicna 7, 128 43, Prague 2 (Czech Republic)

    2009-05-01

    The CSL (CBF1/RBP-J{kappa}/Suppressor of Hairless/LAG-1) family is comprised of transcription factors essential for metazoan development, mostly due to their involvement in the Notch receptor signaling pathway. Recently, we identified two novel classes of CSL genes in the genomes of several fungal species, organisms lacking the Notch pathway. In this study, we characterized experimentally cbf11{sup +} and cbf12{sup +}, the two CSL genes of Schizosaccharomyces pombe, in order to elucidate the CSL function in fungi. We provide evidence supporting their identity as genuine CSL genes. Both cbf11{sup +} and cbf12{sup +} are non-essential; they have distinct expression profiles and code for nuclear proteins with transcription activation potential. Significantly, we demonstrated that Cbf11 recognizes specifically the canonical CSL response element GTG{sup A}/{sub G}GAA in vitro. The deletion of cbf11{sup +} is associated with growth phenotypes and altered colony morphology. Furthermore, we found that Cbf11 and Cbf12 play opposite roles in cell adhesion, nuclear and cell division and their coordination. Disturbed balance of the two CSL proteins leads to cell separation defects (sep phenotype), cut phenotype, and high-frequency diploidization in heterothallic strains. Our data show that CSL proteins operate in an organism predating the Notch pathway, which should be of relevance to the understanding of (Notch-independent) CSL functions in metazoans.

  6. Forum Engelberg 2004 to be launched in Bern on 13 November

    CERN Multimedia

    2003-01-01

    "Former French science minister Hubert Curien will be among major figures from European politics and science meeting in Bern on 13 November to launch the Forum Engelberg 2004.... Forum Engelberg provides a valuable platform for science and a forum for scientists and politicians to meet. The topic of its 2004 conference, to be held in Lucerne from 1 to 4 March 2004, is "Science on the Agenda of European Politics" (1 page).

  7. Interview de Antonio Ereditato de l'université de Bern

    CERN Multimedia

    2011-01-01

    “This result comes as a complete surprise,” said OPERA spokesperson, Antonio Ereditato of the University of Bern. “After many months of studies and cross checks we have not found any instrumental effect that could explain the result of the measurement. While OPERA researchers will continue their studies, we are also looking forward to independent measurements to fully assess the nature of this observation.”

  8. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to a combination of Lactobacillus delbrueckii subsp. bulgaricus AY/CSL (LMG P-17224) and Streptococcus thermophilus 9Y/CSL (LMG P-17225) and “beneficial modulation

    DEFF Research Database (Denmark)

    Tetens, Inge

    of a health claim related to a combination of Lactobacillus delbrueckii subsp. bulgaricus AY/CSL (LMG P-17224) and Streptococcus thermophilus 9Y/CSL (LMG P-17225) and “beneficial modulation of intestinal microflora”. The scope of the application was proposed to fall under a health claim referring to children......’s development and health. The food constituent that is the subject of the health claim, a combination of L. delbrueckii subsp. bulgaricus AY/CSL (LMG P-17224) and S. thermophilus 9Y/CSL (LMG P-17225), has not been sufficiently characterised. The claimed effect is “beneficial modulation of the intestinal...... that a cause and effect relationship has not been established between the consumption of the food constituent, the combination of L. delbrueckii subsp. bulgaricus AY/CSL (LMG P-17224) and S. thermophilus 9Y/CSL (LMG P-17225), and a beneficial physiological effect related to “beneficial modulation...

  9. N-termini of fungal CSL transcription factors are disordered, enriched in regulatory motifs and inhibit DNA binding in fission yeast.

    Directory of Open Access Journals (Sweden)

    Martin Převorovský

    Full Text Available BACKGROUND: CSL (CBF1/RBP-Jκ/Suppressor of Hairless/LAG-1 transcription factors are the effector components of the Notch receptor signalling pathway, which is critical for metazoan development. The metazoan CSL proteins (class M can also function in a Notch-independent manner. Recently, two novel classes of CSL proteins, designated F1 and F2, have been identified in fungi. The role of the fungal CSL proteins is unclear, because the Notch pathway is not present in fungi. In fission yeast, the Cbf11 and Cbf12 CSL paralogs play antagonistic roles in cell adhesion and the coordination of cell and nuclear division. Unusually long N-terminal extensions are typical for fungal and invertebrate CSL family members. In this study, we investigate the functional significance of these extended N-termini of CSL proteins. METHODOLOGY/PRINCIPAL FINDINGS: We identify 15 novel CSL family members from 7 fungal species and conduct bioinformatic analyses of a combined dataset containing 34 fungal and 11 metazoan CSL protein sequences. We show that the long, non-conserved N-terminal tails of fungal CSL proteins are likely disordered and enriched in phosphorylation sites and PEST motifs. In a case study of Cbf12 (class F2, we provide experimental evidence that the protein is proteolytically processed and that the N-terminus inhibits the Cbf12-dependent DNA binding activity in an electrophoretic mobility shift assay. CONCLUSIONS/SIGNIFICANCE: This study provides insight into the characteristics of the long N-terminal tails of fungal CSL proteins that may be crucial for controlling DNA-binding and CSL function. We propose that the regulation of DNA binding by Cbf12 via its N-terminal region represents an important means by which fission yeast strikes a balance between the class F1 and class F2 paralog activities. This mode of regulation might be shared with other CSL-positive fungi, some of which are relevant to human disease and biotechnology.

  10. The structural and thermodynamical properties of binary ellipsoidal fluid mixture Gay-Berne interaction

    Directory of Open Access Journals (Sweden)

    M. Moradi

    2007-06-01

    Full Text Available  In this paper, a uniform classical fluid mixture comprising ellipsoidal molecules is studied. This mixture is composed of two types of ellipsoidal molecules interacting through the Gay-Berne potential with different sizes at temperature T. For this system, the Ornstein-Zernike equation using the Percus-Yevick closure relation is solved. Then the direct correlation function, pair correlation function and the pressure of the fluid at temperature T are calculated. The obtained results are in agreement with the previous theories and the results of molecular dynamic computer simulation.

  11. Übergang von Fachhochschulabsolventinnen und -absolventen in den Arbeitsmarkt – am Beispiel der HSW Bern

    OpenAIRE

    Wolter, Stefan C.; Bonassi, Tamara; Pätzmann, Monika

    2002-01-01

    Mit der Schaffung der Fachhochschulen in der Schweiz ist das Bedürfnis nach Informationen über die Positionierung und Funktionstüchtigkeit dieses Zweiges des tertiären Bildungswesens stark gestiegen. Der vorliegende Artikel zeigt Resultate einer ersten Analyse von drei Jahrgängen von Diplomierten der Hochschule für Wirtschaft und Verwaltung in Bern (HSW). Zwei Fragestellungen stehen dabei im Vordergrund: Erstens werden aus der Sicht der Absolventinnen und Absolventen Einschätzungen der Releva...

  12. Accelerator and detector physics at the Bern medical cyclotron and its beam transport line

    Directory of Open Access Journals (Sweden)

    Auger Martin

    2016-03-01

    Full Text Available The cyclotron laboratory for radioisotope production and multi-disciplinary research at the Bern University Hospital (Inselspital is based on an 18-MeV proton accelerator, equipped with a specifically conceived 6-m long external beam line, ending in a separate bunker. This facility allows performing daily positron emission tomography (PET radioisotope production and research activities running in parallel. Some of the latest developments on accelerator and detector physics are reported. They encompass novel detectors for beam monitoring and studies of low current beams.

  13. CSL Wave Function Collapse Model as a Mechanism for the Emergence of Cosmological Asymmetries in Inflation

    CERN Document Server

    Cañate, Pedro; Sudarsky, Daniel

    2012-01-01

    As previously discussed in (D. Sudarsky, Int.J.Mod.Phys.D20:509-552, (2011); [arXiv:0906.0315]), the inflationary account for the emergence of the seeds of cosmic structure falls short of actually explaining the generation of primordial anisotropies and inhomogeneities. This description starts from a symmetric background, and invokes symmetric dynamics, so it cannot explain asymmetries. To generate asymmetries, we present an application of the Continuous Spontaneous Localization (CSL) model of wave function collapse (P. Pearle, Phys. Rev. A 39, 2277, (1989); G. C. Ghirardi, P. Pearle and A. Rimini, Phys. Rev. A42, 78 (1990)) in the context of inflation. This modification of quantum dynamics introduces a stochastic non-unitary component to the evolution of the inflaton field perturbations. This leads to passage from a homogeneous and isotropic stage to another, where the quantum uncertainties in the initial state of inflation transmute into the primordial inhomogeneities and anisotropies. We examine requiremen...

  14. Gravitational lensing by cosmic strings: what we learn from the CSL-1 case

    CERN Document Server

    Sazhin, M V; Capaccioli, M; Longo, G; Paolillo, M; Covone, G; Grogin, N A; Schreier, E J

    2006-01-01

    Cosmic strings were postulated by Kibble in 1976 and, from a theoretical point of view, their existence finds support in modern superstring theories, both in compactification models and in theories with extended additional dimensions. Their eventual discovery would lead to significant advances in both cosmology and fundamental physics. One of the most effective ways to detect cosmic strings is through their lensing signatures which appear to be significantly different from those introduced by standard lenses (id est, compact clumps of matter). In 2003, the discovery of the peculiar object CSL-1 (Sazhin et al.2003) raised the interest of the physics community since its morphology and spectral features strongly argued in favour of it being the first case of gravitational lensing by a cosmic string. In this paper we provide a detailed description of the expected observational effects of a cosmic string and show, by means of simulations, the lensing signatures produced on background galaxies. While high angular r...

  15. A computer simulation of a potential derived from the gay-berne potential for lattice model

    Directory of Open Access Journals (Sweden)

    Habtamu Zewdie

    2000-06-01

    Full Text Available The lattice model of elongated molecules interacting via a potential derived from the Gay-Berne pair potential is proposed. We made a systematic study of the effect of varying the molecular elongation and intermolecular vector orientation dependence of the pair potential on the thermodynamic as well as the structural properties of liquid crystals. A Monte Carlo simulations of molecules placed at the site of a simple cubic lattice and interacting via the modified Gay-Berne potential with its nearest neighbours is performed. The internal energy, heat capacity, angular pair correlation function and scalar order parameter are obtained. The results are compared against predictions of molecular field theory, experimental results and that of other related simulations wherever possible. It is shown that for more elongated molecules the nematic-isotropic transition becomes stronger first order transition. For a given molecular elongation as the intermolecular vector orientation dependence becomes larger the nematic-isotropic transition becomes a stronger first order transition as measured by the rate of change of the order parameter and the divergence of the heat capacity. Scaling the potential well seems to have dramatic change on the effect of the potential well anisotropy on trends of nematic-isotropic transition temperature and divergence of the heat capacity. It is shown that the behaviour of many nematics can be described by proposed model with the elongation ratio of molecules and potential well anisotropy ranging from 3 to 5.

  16. Frequency of eprinomectin resistance in gastrointestinal nematodes of goats in canton Berne, Switzerland.

    Science.gov (United States)

    Murri, Sarah; Knubben-Schweizer, Gabriela; Torgerson, Paul; Hertzberg, Hubertus

    2014-06-16

    Eprinomectin (EPN) is a member of the avermectin class of compounds and the only anthelmintic registered for goats in Switzerland with a zero milk withdrawal period. The aim of the present study was to identify the actual efficacy of EPN in an area with a higher density of goat enterprises. Forty-three randomly chosen farms from canton Berne were investigated. At least eight goats were investigated on every farm. Conditions for inclusion in the study were the absence of anthelmintic treatment during the previous six weeks and a pooled faecal sample showing a mean faecal egg count (FEC) higher than 600 epg faeces. Pre- and 14-16 days post-treatment samples were individually collected directly from the rectum. Animals were treated with the recommended dose of EPN (1 mg/kg body weight) after taking the pre-treatment samples. Efficacy of EPN was tested with the faecal egg count reduction test (FECRT) and faecal cultures were performed on every farm from pooled faeces samples before and after treatment. Additionally the farmers completed a questionnaire. None of the gastrointestinal nematode populations of the 43 investigated farms were susceptible to EPN at the required level. The mean egg count reduction was 40%. None of the typical risk factors, such as production type, stocking rate, animal traffic and quarantine measures showed an association with the level of eprinomectin resistance. It can be concluded with 80% certainty that the prevalence of EPN resistance on goat farms is at least 95% in canton Berne.

  17. Caracterização da variabilidade da mosca do berne Dermatobia hominis (Diptera : oestridae) atraves de dois marcadores moleculares

    OpenAIRE

    Taila Andrade Lemos

    2000-01-01

    Resumo: Dermatobia hominis (Linnaus Jr.) conhecida popularmente como mosca do berne. É uma das principais causadoras de miíase primária em vertebrados. sendo uma das principais pragas da pecuária nacional. causando grandes prejuízos à industria coureira. laticínios e frigoríficos. A mosca do berne apresenta uma biologia interessante e ciclo de vida bastante peculiar. o que dificuta a observação da espécie na natureza e a manutenção desta em laboratório. Por estes motivos. a caracterização da ...

  18. U(1) decoupling, Kleiss-Kuijf and Bern-Carrasco-Johansson relations in N=4 super Yang-Mills

    Science.gov (United States)

    Jia, Yin; Huang, Rijun; Liu, Chang-Yong

    2010-09-01

    By using the Britto-Cachazo-Feng-Witten recursion relation of N=4 super Yang-Mills theory, we proved the color reflection, U(1) decoupling, Kleiss-Kuijf and Bern-Carrasco-Johansson relations for color-ordered amplitudes of N=4 super Yang-Mills theory. This proof verified the conjectured Bern-Carrasco-Johansson relations of matter fields. The proof depended only on general properties of superamplitudes. We showed also that the color reflection relation and U(1)-decoupling relation are special cases of Kleiss-Kuijf relations.

  19. Die Entwicklung des Innovationsmanagements an der Universitätsbibliothek Bern

    Directory of Open Access Journals (Sweden)

    Petra Redmond

    2015-11-01

    Full Text Available Das Innovationsmanagement dient der aktiven Gestaltung von Wandlungsprozessen, welche es der Bibliothek ermöglichen, rasch auf das sich schnell verändernde Bibliotheksumfeld zu reagieren. Innovativ sein heisst folglich auch, sich ständig zu verändern. Somit sollen sich auch im Innovationsmanagement Prozesse, Strukturen und Schwerpunkte stetig wandeln können und daher sollten sie laufend evaluiert werden. Aus diesem Grund wurde zu Beginn des Innovationsmanagements an der Universitätsbibliothek Bern beschlossen, nach zwei Jahren eine erste Evaluation durchzuführen, um die Prozesse und Kernaufgaben der aktuellen Situation anpassen zu können. Die Ergebnisse zeigten, dass eine stärkere Fokussierung auf strategische Handlungsschwerpunkte und die Förderung der internen Innovationskultur notwendig sind. Als neuen Schwerpunkt setzt die UB Bern nun auf die Implementierung einer systematischen Kundenforschung. Mögliche weitere Erfolgsfaktoren für ein gelingendes Innovationsmanagement sind die enge Verknüpfung zum Projektmanagement und die Einführung eines Produktmanagements. Innovation Management is actively shaping processes which will enable libraries to respond to rapidly changing environments. Being innovative means, therefore, being able to adapt to change and disruption. Processes, structures and focuses in innovation management are also subjected to change and, as a consequence, should be constantly evaluated. For this reason, at the beginning of the implementation of innovation management at University Library Bern the decision had been taken to perform an evaluation after 2 years in order to adjust the processes and core functions to the current situation. The results highlighted that both a stronger focus on strategic priorities and the promotion of internal culture of innovation are necessary. For this purpose, UB Bern focuses on the implementation of a systematic customer research. Other possible factors for successful innovation

  20. L’affaire de Berne. Immaculée conception et apparitions de la Vierge

    Directory of Open Access Journals (Sweden)

    Sylvie Barnay

    2012-04-01

    Full Text Available En janvier 1507, les « apparitions de la Vierge » dans le couvent dominicain de Berne commencent à défrayer la chronique. L’affaire des visions de Jean Jetzer se déroule sur fond de querelle immaculiste entre dominicains et franciscains. Les dominicains du couvent de Berne ont eu l’idée de créer des apparitions de la Vierge de toutes pièces au moyen de déguisement et de machineries de théâtre pour faire croire à la conception maculée de Marie contre leurs détracteurs franciscains. Leur chef de file est le prieur du couvent, Johannes Vatter, assisté de trois autres accolytes, le sous-prieur, Franz Ueltschi, le maître en théologie et lecteur Stephan Boltzhurst, l’administrateur Heirich Steinegger. La machination qu’ils orchestrent érige de la sorte en visionnaire patenté un novice à la crédulité éprouvée, Jean Jetzer, victime de leur complot. L’affaire défie la chronique et provoque la rumeur. La ville de Berne où elle se déroule est toute proche de la Bâle du Concile (1431-1449 qui a déclaré l’Immaculée Conception « doctrine pieuse et conforme au culte de l’Église » (session du 17 septembre 1439 comme de la Bâle du Formicarius – somme démonologique de répression de la sorcellerie – composée en 1435-1437 par le prieur des dominicains, Jean Nider, sur la base des conclusions de l'inquisiteur Pierre de Berne. La « fiction » de Berne témoigne des stratégies théologiques à l’égard des révélations et des miracles dans la controverse de l’Immaculée Conception. Si elle relève ici de l’affabulation volontaire, elle montre aussi l’usage qui pouvait être fait du discours visionnaire et de son nécessaire discernement à la toute fin du Moyen Âge. L’ensemble de ce dossier exceptionnel permet dès lors de saisir l’instrumentalisation des révélations qui ont pris une importance nouvelle dans les querelles théologiques de l’Immaculée Conception à la fin du Moyen Âge.

  1. EU Regulation 1143/2014 and the Bern Convention : Allied forces in the war on invasive alien species

    NARCIS (Netherlands)

    Trouwborst, Arie

    2015-01-01

    This article identifies and analyzes current and potential synergies between the new EU Regulation 1143/2014 on the prevention and management of the introduction and spread of invasive alien species on the one hand, and the Bern Convention on the Conservation of European Wildlife and Natural Habitat

  2. „e-Day“ in Bern: Ein ganztätiger Event zur Bewerbung von e-Ressourcen

    Directory of Open Access Journals (Sweden)

    Grosjean, Stefan

    2016-12-01

    Full Text Available For the first time, a joint event between the library, the medical faculty, and external partners was held at the medical library of Bern University. With a combination of promotional and social activities and information skills taster sessions the library tried to raise awareness of e-resources and increase their use.

  3. Small hydro project in Wohlen, Bern - Preliminary study; Programm Kleinwasserkraftwerke. KWKW Hofenmuehle, Wohlen BE - Vorstudie

    Energy Technology Data Exchange (ETDEWEB)

    Fritschi, M.; Spescha, P.

    2008-11-15

    This report for the Swiss Federal Office of Energy (SFOE) presents the preliminary project study for the refurbishment of an existing small hydropower installation in Wohlen, Bern, Switzerland. The installation is in the Hofenmuehle, a listed mill complex dating from the first half of the nineteenth century. The headrace channel has already been refurbished by a community service group. The high level of financial effort and the idealism of the owner families are noted. The existing installations are described in detail. The refurbishment of the technical equipment and the associated work such as water-flow measurements are discussed. Cost estimates and environmental aspects are presented and discussed as are the financing of the refurbishment work and the cost-covering remuneration for the power produced. A possible increase in the power produced and the associated water-usage concession are discussed.

  4. [Tension field alcohol and violence - viewpoint of the safety director of the city of Bern].

    Science.gov (United States)

    Horn, Benedikt; Nause, Hern Reto

    2014-10-01

    Es ist immer wieder interessant und heilsam, zu einem Problem die Meinung von Sachverständigen außerhalb der Medizin zu kennen. Wenn wir die Tagespresse lesen, haben wir oft das Gefühl, öffentliche Besäufnis und Schlägereien seien weitherum an der Tagesordnung. Mein Haupt-Fazit nach dem Interview: 1. Bern ist eine sehr sichere Stadt. 2. Alkoholisierte sind bei gewalttätigen Auseinandersetzungen häufiger Opfer als Täter. 3. Das Problem ist nie lokal, sondern regional oder überregional. 4. Lärm und Littering als wichtigste „Nebenwirkungen“ werden von den Behörden sehr ernst genommen.

  5. Development of a citation style language CSL to describe the formatting of citations, notes and bibliographies of agricultural scientific articles

    Directory of Open Access Journals (Sweden)

    Rafael Cervantes Beyra

    2015-01-01

    Full Text Available El desarrollo de ficheros de estilos bibliográficos que puedan ser acoplados a gestores de información científica, es una opción viable para reducir los errores en forma de los artículos que se presentan en las revistas de corte agropecuario. En ocasiones, los comités editoriales se ven envueltos en tediosos trabajos de corrección bibliográfica que muchas veces terminan con la devolución de numerosos documentos por este motivo. Los estilos CSL (procesadores de citas, notas y bibliografías permiten realizar el asentamiento automático de las referencias utilizadas según las exigencias de cada revista y pueden ser cargados por una amplia gama gestores de reconocida preferencia; por lo que constituyen una potente e indispensable herramienta en la elaboración de documentos científicos. Es por ello que el objetivo de este trabajo fue confeccionar un lenguaje de estilo de citas CSL basado en la norma ISO 690:2010 para asentar la bibliografía de los artículos presentados en la Revista Ciencias Técnicas Agropecuarias (RCTA. Para la confección del mismo se utilizó el esquema CSL v1.0, con lenguaje XML, formato de codificación de caracteres utf-8 y tipo de citas en texto autor-año. Las operaciones de edición y validación se realizaron a través del editor de texto plano Notepad++ v4.7.5, el Visual CSL Editor (online y el Validator.nu (online. Como resultado se obtuvo un fichero CSL compatible con 25 gestores bibliográficos que permite asentar de manera automática la bibliografía de los artículos científicos agropecuarios de RCTA, según las directrices de la norma ISO 690:2010.

  6. CSL101与LFP-901线路保护重合闸应用问题的分析%ANALYSIS OF APPLICATION OF AUTO-RECLOSURES PROVIDED BY LINE PROTECTIONS CSL-101 AND LFP-901

    Institute of Scientific and Technical Information of China (English)

    林榕; 曹树江

    2003-01-01

    目前在电力系统中大量采用了CSL101B与LFP-901A双微机线路保护配合使用的模式,作者对两者使用中出现的主要问题特别是重合闸应用中易被忽视的问题作了详细分析,并提出了具体的解决办法和使用方案,供继电保护同行参考.

  7. Quantitative proteomic analysis of the effects of a GalNAc/Man-specific lectin CSL on yeast cells by label-free LC-MS.

    Science.gov (United States)

    Liu, Shuai; Li, Linge; Tong, Changqing; Zhao, Qiancheng; Lukyanov, Pavel A; Chernikov, Oleg V; Li, Wei

    2016-04-01

    A Ca(2+)-dependent GalNAc/Man-specific lectin (CSL) from Cyclina sinensis was isolated, and its stimulatory action was characterized in yeast. CSL showed a potent effect on the production of ethanol by Saccharomyces cerevisiae. In this work, the changes in the protein expression profiles of S. cerevisiae after 24h of incubation with CSL were analyzed using label-free quantitative proteomics. A total of 1410 proteins were identified, but only 117 proteins showed significant differences in normalized volume (p<0.05). Among the latter proteins, 24 proteins were up-regulated, and 93 were down-regulated. Analysis of the proteome revealed that CSL triggered changes in the concentrations of some enzymes, such as increased expression of hexokinase, glyceraldehyde 3-phosphate dehydrogenase and enolase and decreased expression of dihydrolipoamide dehydrogenase and aldehyde dehydrogenase. These results indicate that CSL can cause some changes in the metabolic pathway involved in ethanol synthesis in S. cerevisiae. These data may help us understand the stimulatory mechanism of lectin in the fermentation process.

  8. Perception of Medical Students about Communication Skills Laboratory (CSL) in a Rural Medical College of Central India

    Science.gov (United States)

    Jagzape, Arunita Tushar; Vagha, Jayant Dattatray; Chalak, Anita; Meshram, Revatdhamma Jagdish

    2015-01-01

    Introduction “The art of medicine is intricately tied to the art of communication.” In traditional medical curriculum, communication is not taught formally and this leads to a gap in reliability and consistency of the teaching. Few studies have shown that much litigation against doctors is due to lack of communication and not because of lack of clinical expertise. Considering the importance of training in communication skills, it was included in the curriculum of students of DMIMS (DU), which has got probably the first communication skills lab in a medical college in India. Aim To study the perception of medical students about usefulness of communication skills lab. Materials and Methods This observational study was carried out at Communication Skills Lab (CSL) of Jawaharlal Nehru Medical College, Sawangi (M), Wardha, Maharasthra. Feedback was obtained with the help of a prevalidated questionnaire from 65 final MBBS students about their perception about utility of the module taught in the CSL including factors which helped and which hindered in learning. Descriptive statistics was used for the quantitative data and categorization for qualitative data. Results A total of 78.46% students were of the idea that CSL posting is must for all medical undergraduates. A 93.83% perceive that the module taught was very relevant and useful and were satisfied with the duration of posting (81.47%). A 78.46% students experienced improvement in their communication skills. They opined that more emphasis should be given on communication between doctor and patient (61.53%). Conclusion The students found communication skills lab very useful. They desired more emphasis on communication between doctor and patient and sought more interactivity, video demonstrations to be part of the module. PMID:26816918

  9. VHDL-based system design of a cognitive sensorimotor loop (CSL) for haptic Human-Machine Interaction (HMI)

    OpenAIRE

    Miguel Morales, Pablo de

    2015-01-01

    This document is a summary of the Bachelor thesis titled “VHDL-Based System Design of a Cognitive Sensorimotor Loop (CSL) for Haptic Human-Machine Interaction (HMI)” written by Pablo de Miguel Morales, Electronics Engineering student at the Universidad Politécnica de Madrid (UPM Madrid, Spain) during an Erasmus+ Exchange Program at the Beuth Hochschule für Technik (BHT Berlin, Germany). The tutor of this project is Dr. Prof. Hild. This project has been developed inside the Neurobotics Researc...

  10. Abrogation of cisplatin-induced nephrotoxicity in rats by Berne date extract through ameliorating oxidative stress, inflammation and apoptosis

    Directory of Open Access Journals (Sweden)

    El-Sayed M. El-Sayed

    2015-09-01

    Full Text Available Our study aimed to investigate the possible protective effect of Berne date extract on cisplatin-induced nephrotoxicity. A single dose of cisplatin (6 mg/kg was given intraperitoneally (i.p to male rats produced significant elevation in serum urea, creatinine and TNF-α levels with significant reduction in serum albumin. It also increased kidney contents of lipid peroxides measured as malondialdehyde (MDA and caspase-3 contents accompanied by a significant decrease in kidney contents of reduced glutathione (GSH as well as enzymatic activities of catalase (CAT and superoxide dismutase (SOD compared to that of the control group. On the other hand, administrations of Berne date extract and vitamin E (a standard reference antioxidant drug given per os (p.o in doses of 300 mg/kg and 1g/kg, respectively for 14 days before cisplatin and 7 consecutive days after cisplatin injection ameliorated the cisplatin-induced nephrotoxicity as indicated by the restoration of kidney function and oxidative stress parameters. Furthermore, they reduced the histopathological changes induced by cisplatin. In conclusion, Berne date extract showed protective effect against cisplatin-induced nephrotoxicity; effects that may be attributed to antioxidant, anti-inflammatory and antiapoptotic activities.

  11. The Wankdorf stadium of Bern revives; Sports et loisirs. Le stade du Wankdorf renait

    Energy Technology Data Exchange (ETDEWEB)

    Pallastrelli, C.

    2004-07-01

    After its complete demolition a new stadium will be erected on the old Wankdorf site of Bern. The new stadium will accommodate 32,000 seated people being protected from rain by a metallic roof. On the floor below, the building contains a large shopping center, several restaurants and conference rooms. 12,000 to 15,000 'visitors' are expected here each day. The stadium is a reinforced concrete construction covered by a metallic superstructure. The roof will accommodate an impressive number of photovoltaic panels, so that this installation will be the largest of this type in Switzerland and even the largest solar installation on a stadium in Europe. Its maximum power will be at least 600 kW, with a possible future increase to 1,000 kW. These values correspond to panel areas of 6,000 m{sup 2} and 8,700 m{sup 2} respectively. A very sophisticated heating and ventilation system with efficient waste heat recovery will allow to minimize the energy consumption during wintertime.

  12. Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of antibody CSL362.

    Science.gov (United States)

    Broughton, Sophie E; Hercus, Timothy R; Nero, Tracy L; Dhagat, Urmi; Owczarek, Catherine M; Hardy, Matthew P; Fabri, Louis J; Scotney, Pierre D; Nash, Andrew D; Wilson, Nicholas J; Lopez, Angel F; Parker, Michael W

    2014-03-01

    Interleukin-3 (IL-3) is a member of the beta common family of cytokines that regulate multiple functions of myeloid cells. The IL-3 receptor-specific alpha subunit (IL3Rα) is overexpressed on stem cells/progenitor cells of patients with acute myeloid leukaemia, where elevated receptor expression correlates clinically with a reduced patient survival rate. The monoclonal antibody (MAb) CSL362 is a humanized MAb derived from the murine MAb 7G3, originally identified for its ability to specifically recognize the human IL-3 receptor and for blocking the signalling of IL-3 in myeloid and endothelial cells. In order to elucidate the molecular mechanism of CSL362 antagonism, a preliminary structure of human IL3Rα in complex with the MAb CSL362 has been determined.

  13. Intercomparison of stratospheric ozone profiles for the assessment of the upgraded GROMOS radiometer at Bern

    Directory of Open Access Journals (Sweden)

    S. Studer

    2013-07-01

    Full Text Available Since November 1994, the GROund-based Millimeter-wave Ozone Spectrometer (GROMOS measures stratospheric and lower mesospheric ozone in Bern, Switzerland (47.95° N, 7.44° E. GROMOS is part of the Network for the Detection of Atmospheric Composition Change (NDACC. In July 2009, a Fast-Fourier-Transform spectrometer (FFTS has been added as backend to GROMOS. The new FFTS and the original filter bench (FB measured parallel for over two years. In October 2011, the FB has been turned off and the FFTS is now used to continue the ozone time series. For a consolidated ozone time series in the frame of NDACC, the quality of the stratospheric ozone profiles obtained with the FFTS has to be assessed. The FFTS results from July 2009 to December 2011 are compared to ozone profiles retrieved by the FB. FFTS and FB of the GROMOS microwave radiometer agree within 5% above 20 hPa. A later harmonization of both time series will be realized by taking the FFTS as benchmark for the FB. Ozone profiles from the FFTS are also compared to coinciding lidar measurements from the Observatoire Haute Provence (OHP, France. For the time period studied a maximum mean difference (lidar – GROMOS FFTS of +3.8% at 3.1 hPa and a minimum mean difference of +1.4% at 8 hPa is found. Further, intercomparisons with ozone profiles from other independent instruments are performed: satellite measurements include MIPAS onboard ENVISAT, SABER onboard TIMED, MLS onboard EOS Aura and ACE-FTS onboard SCISAT-1. Additionally, ozonesondes launched from Payerne, Switzerland, are used in the lower stratosphere. Mean relative differences of GROMOS FFTS and these independent instruments are less than 10% between 50 and 0.1 hPa.

  14. Early Detection and Treatment of Psychosis: The Bern Child and Adolescent Psychiatric Perspective

    Directory of Open Access Journals (Sweden)

    Frauke Schultze-Lutter

    2014-01-01

    Full Text Available Commonly conceptualized as neurodevelopmental disorders of yet poorly understood aetiology, schizophrenia and other nonorganic psychoses remain one of the most debilitating illnesses with often poor outcome despite all progress in treatment of the manifest disorder. Drawing on the frequent poor outcome of psychosis and its association with the frequently extended periods of untreated first-episode psychosis (FEP including its prodrome, an early detection and treatment of both the FEP and the preceding at-risk mental state (ARMS have been increasingly studied. Thereby both approaches are confronted with different problems, for example, treatment engagement in FEP and predictive accuracy in ARMS. They share, however, the problems related to the lack of understanding of developmental, that is, age-related, peculiarities and of the presentation and natural course of their cardinal symptoms in the community. Most research on early detection and intervention in FEP and ARMS is still related to clinical psychiatric samples, and little is known about symptom presentation and burden and help-seeking in the general population related to these experiences. Furthermore, in particular in the early detection of an ARMS, studies often address adolescents and young adults alike without consideration of developmental characteristics, thereby applying risk criteria that have been developed predominately in adults. Combining our earlier experiences described in this paper in child and adolescent, and general psychiatry as well as in both lines of research, that is, on early psychosis and its treatment and on the early detection of psychosis, in particular in its very early states by subjective disturbances in terms of basic symptoms, age-related developmental and epidemiological aspects have therefore been made the focus of our current studies in Bern, thus making our line of research unique.

  15. The Effects of Wiki-Based Recursive Process Writing on Chinese Narrative Essays for Chinese as a Second Language (CSL) Students in Singapore

    Science.gov (United States)

    Chin, Chee Kuen; Gong, Cheng; Tay, Boon Pei

    2015-01-01

    This paper reports on the effects of using wiki-based process writing in Singapore's Chinese as a Second Language (CSL) scenarios. A group of 32 Secondary 1 (Seventh Grade) students ("Students") received various forms of online scaffolding at different steps of the writing process over two years. A whole set of teaching materials on 45…

  16. Safety and efficacy of Lactobacillus acidophilus D2/CSL (Lactobacillus acidophilus CECT 4529) as a feed additive for chickens for fattening

    National Research Council Canada - National Science Library

    Rychen, Guido; Aquilina, Gabriele; Azimonti, Giovanna; Bampidis, Vasileios; Bastos, Maria De Lourdes; Bories, Georges; Chesson, Andrew; Cocconcelli, Pier Sandro; Flachowsky, Gerhard; Gropp, Jürgen; Kolar, Boris; Kouba, Maryline; López Alonso, Marta; López Puente, Secundino; Mantovani, Alberto; Mayo, Baltasar; Ramos, Fernando; Villa, Roberto Edoardo; Wallace, Robert John; Wester, Pieter; Brozzi, Rosella; Saarela, Maria

    2017-01-01

    ... ) was asked to deliver a scientific opinion on the safety and efficacy of Lactobacillus acidophilus D2/ CSL when used in feed for chickens for fattening at a minimum dose of 1 × 10 9  colony‐forming units ( CFU...

  17. Effect of Corn Steep Liquor (CSL and Cassava Wastewater (CW on Chitin and Chitosan Production by Cunninghamella elegans and Their Physicochemical Characteristics and Cytotoxicity

    Directory of Open Access Journals (Sweden)

    Lúcia Raquel Ramos Berger

    2014-02-01

    Full Text Available Microbiological processes were used for chitin and chitosan production with Cunninghamella elegans UCP/WFCC 0542 grown in different concentrations of two agro-industrial wastes, corn steep liquor (CSL and cassava wastewater (CW established using a 22 full factorial design. The polysaccharides were extracted by alkali-acid treatment and characterized by infrared spectroscopy, viscosity, thermal analysis, elemental analysis, scanning electron microscopy and X-ray diffraction. The cytotoxicity of chitosan was evaluated for signs of vascular change on the chorioallantoic membrane of chicken eggs. The highest biomass (9.93 g/L was obtained in trial 3 (5% CW, 8% CSL, the greatest chitin and chitosan yields were 89.39 mg/g and 57.82 mg/g, respectively, and both were obtained in trial 2 (10% CW, 4% CSL. Chitin and chitosan showed a degree of deacetylation of 40.98% and 88.24%, and a crystalline index of 35.80% and 23.82%, respectively, and chitosan showed low molecular weight (LMW 5.2 × 103 Da. Chitin and chitosan can be considered non-irritating, due to the fact they do not promote vascular change. It was demonstrated that CSL and CW are effective renewable agroindustrial alternative substrates for the production of chitin and chitosan.

  18. World-line approach to the Bern-Kosower formalism in two-loop Yang-Mills theory

    CERN Document Server

    Sato, H T; Sato, Haru-Tada; Schmidt, Michael G.

    1999-01-01

    Based on the world-line formalism with a sewing method, we derive the Yang-Mills effective action in a form useful to generate the Bern-Kosower-type master formulae for gluon scattering amplitudes at the two-loop level. It is shown that four-gluon ($\\Phi^4$ type sewing) contributions can be encapsulated in the action with three-gluon ($\\Phi^3$ type) vertices only, the total action thus becoming a simple expression. We then derive a general formula for a two-loop Euler-Heisenberg type action in a pseudo-abelian $su(2)$ background. The ghost loop and fermion loop cases are also studied.

  19. Attitude towards and Readiness for Interprofessional Education in Medical and Nursing Students of Bern

    Science.gov (United States)

    Woermann, Ulrich; Weltsch, Lena; Kunz, Alexandra; Stricker, Daniel; Guttormsen, Sissel

    2016-01-01

    Objectives: Interprofessional collaboration is becoming increasingly important in health care for various reasons. Interprofessional Education (IPE) can provide a basis for this. The aim of our study was to find out how medical (MS) and nursing students (NS) think about their own and other professions, what they know about each other, how strong their willingness to embrace IPE is, and what forms of IPE they deem useful. Methodology: Seven IPE experts rated the two measuring instruments, Readiness for Interprofessional Learning Scale RIPLS, and Interdisciplinary Education Perception Scale IEPS in terms of relevance of the items, and the quality of translation into German. Nine RIPLS items and 13 IEPS items were considered content-valid. All MS of the University of Bern and NS of the two Bernese educational institutions for nursing were invited to the online survey in the fall of 2014 by email. Results: 498 (254 MS, 244 NS) of the 2374 invited students completely filled in the questionnaire (21%). The results of the reduced RIPLS allowed no conclusive statements. When assessing their own occupational group in the IEPS, the MS attributed "competence and autonomy" to themselves significantly more frequently, while to the NS, the same was true for the item, "actual cooperation". MS know significantly less about the training of other health professionals. NS show a significantly higher willingness to embrace IPE. Teaching ethics, communication, team training, and clinical skills are deemed suitable for IPE by both groups. From the comments it appears that in both groups a majority welcomes IPE; however, the various arguments had different prevalence in both groups. Both groups fear that IPE leads to heightened stress during the study. A subgroup of MS fears a lowering of academic level. Conclusion: The results of this survey of Bernese MS and NS concerning IPE provide important information for the planning and implementation of IPE. Important steps in the introduction

  20. Variability of mesospheric water vapor above Bern in relation to the 27-day solar rotation cycle

    Science.gov (United States)

    Lainer, Martin; Hocke, Klemens; Kämpfer, Niklaus

    2016-06-01

    Many studies investigated solar-terrestrial responses (thermal state, O3, OH, H2O) with emphasis on the tropical upper atmosphere. In this paper the focus is switched to water vapor in the mesosphere at a mid-latitudinal location. Eight years of water vapor profile measurements above Bern (46.88 ° N / 7.46 ° E) are investigated to study oscillations with the focus on periods between 10 and 50 days. Different spectral analyses revealed prominent features in the 27-day oscillation band, which are enhanced in the upper mesosphere (above 0.1 hPa, ∼ 64 km) during the rising sunspot activity of solar cycle 24. Local as well as zonal mean Aura MLS observations support these results by showing a similar behavior. The relationship between mesospheric water and the solar Lyman-α flux is studied by comparing the similarity of their temporal oscillations. The H2O oscillation is negatively correlated to solar Lyman-α oscillation with a correlation coefficient of up to - 0.3 to - 0.4, and the phase lag is 6-10 days at 0.04 hPa. The confidence level of the correlation is ≥ 99 %. This finding supports the assumption that the 27-day oscillation in Lyman-α causes a periodical photodissociation loss in mesospheric water. Wavelet power spectra, cross-wavelet transform and wavelet coherence analysis (WTC) complete our study. More periods of high common wavelet power of H2O and solar Lyman-α are present when amplitudes of the Lyman-α flux increase. Since this is not a measure of physical correlation a more detailed view on WTC is necessary, where significant (two sigma level) correlations occur intermittently in the 27 and 13-day band with variable phase lock behavior. Large Lyman-α oscillations appeared after the solar superstorm in July 2012 and the H2O oscillations show a well pronounced anti-correlation. The competition between advective transport and photodissociation loss of mesospheric water vapor may explain the sometimes variable phase relationship of mesospheric H2

  1. Attitude towards and Readiness for Interprofessional Education in Medical and Nursing Students of Bern

    Directory of Open Access Journals (Sweden)

    Woermann, Ulrich

    2016-11-01

    Full Text Available Objectives: Interprofessional collaboration is becoming increasingly important in health care for various reasons. Interprofessional Education (IPE can provide a basis for this.The aim of our study was to find out how medical (MS and nursing students (NS think about their own and other professions, what they know about each other, how strong their willingness to embrace IPE is, and what forms of IPE they deem useful.Methodology: Seven IPE experts rated the two measuring instruments, Readiness for Interprofessional Learning Scale RIPLS, and Interdisciplinary Education Perception Scale IEPS in terms of relevance of the items, and the quality of translation into German. Nine RIPLS items and 13 IEPS items were considered content-valid. All MS of the University of Bern and NS of the two Bernese educational institutions for nursing were invited to the online survey in the fall of 2014 by email. Results: 498 (254 MS, 244 NS of the 2374 invited students completely filled in the questionnaire (21%.The results of the reduced RIPLS allowed no conclusive statements. When assessing their own occupational group in the IEPS, the MS attributed "competence and autonomy" to themselves significantly more frequently, while to the NS, the same was true for the item, "actual cooperation". MS know significantly less about the training of other health professionals. NS show a significantly higher willingness to embrace IPE. Teaching ethics, communication, team training, and clinical skills are deemed suitable for IPE by both groups. From the comments it appears that in both groups a majority welcomes IPE; however, the various arguments had different prevalence in both groups. Both groups fear that IPE leads to heightened stress during the study. A subgroup of MS fears a lowering of academic level. Conclusion: The results of this survey of Bernese MS and NS concerning IPE provide important information for the planning and implementation of IPE. Important steps in the

  2. Auger electron-emitting (111)In-DTPA-NLS-CSL360 radioimmunoconjugates are cytotoxic to human acute myeloid leukemia (AML) cells displaying the CD123(+)/CD131(-) phenotype of leukemia stem cells.

    Science.gov (United States)

    Gao, Catherine; Leyton, Jeffrey V; Schimmer, Aaron D; Minden, Mark; Reilly, Raymond M

    2016-04-01

    Chimeric IgG1 monoclonal antibody CSL360 recognizes the CD123(+)/CD131(-) phenotype expressed by leukemic stem cells (LSC). Auger electron-emitting (111)In-DTPA-NLS-CSL360 radioimmunoconjugates incorporating nuclear translocation sequence (NLS) peptides bound specifically to Raji cells transfected with CD123 and exhibited a KD of 11nmols/L in a competition receptor-binding assay using CD123-transfected CHO cells. (111)In-DTPA-NLS-CSL360 was bound, internalized and transported to the nucleus of human AML-5 myeloid leukemia cells. The clonogenic survival of AML-5 cells was reduced by (111)In-DTPA-NLS-CSL360 up to 3.7-fold. Isotype control (111)In-DTPA-chIgG1 was 2-fold less cytotoxic, and unlabeled CSL360, DTPA-NLS-CSL360 or free (111)In acetate did not decrease cell survival. These results are promising for further evaluation of (111)In-DTPA-NLS-CSL360 for Auger electron radioimmunotherapy of AML targeting the critical LSC subpopulation. Copyright © 2015 Elsevier Ltd. All rights reserved.

  3. Measurements of CO2, its stable isotopes, O2/N2, and 222Rn at Bern, Switzerland

    Directory of Open Access Journals (Sweden)

    P. Sturm

    2006-01-01

    Full Text Available A one-year time series of atmospheric CO2 measurements from Bern, Switzerland, is presented. O2/N2 and Ar/N2 ratios as well as stable carbon and oxygen isotopes of CO2 and δ29N2, δ34O2 and δ36Ar were measured periodically during a one year period. Additionally, the 222Rn activity was measured during three months in the winter 2004. Using the correlation from short-term fluctuations of CO2 and 222Rn we estimated a mean CO2 flux density between February 2004 and April 2004 in the region of Bern of 95±39 tC km–2month–1. The continuous observations of carbon dioxide and associated tracers shed light on diurnal and seasonal patterns of the carbon cycle in an urban atmosphere. There is considerable variance in nighttime δ13C and δ18O of source CO2 throughout the year, however, with generally lower values in winter compared to summertime. The O2:CO2 oxidation ratio during the nighttime build-up of CO2 varies between –0.96 and –1.69 mol O2/mol CO2. Furthermore, Ar/N2 measurements showed that artifacts like thermal fractionation at the air intake are relevant for high precision measurements of atmospheric O2.

  4. [{sup 11}C]S.L.(25.1188), a new radioligand to study the monoamine oxidase type B with PET: preclinical characterisation

    Energy Technology Data Exchange (ETDEWEB)

    Saba, W.; Valette, H.; Peyronneau, M.A.; Bramoulle, Y.; Coulon, C.; Dolle, F.; Bottlaender, M. [Service Hospitalier Frederic Joliot, IIBM/DSV, 91 - Orsay (France); Curet, O.; George, P. [Sanofi-Aventis, 92 - Bagneux (France)

    2008-02-15

    Introduction. - Monoamine oxidase (M.A.O.) is a flavin containing enzyme, that catalyzes the oxidative deamination of various amines and neurotransmitters. Two isoforms exist, M.A.O.-A and M.A.O.-B. Variations in M.A.O. activity may be associated to human disease such as Parkinson and Alzheimer disease. Few radiotracers have been developed for M.A.O. PET studies such as [{sup 11}C]deprenyl, an irreversible M.A.O.-B inhibitor. Recently an oxazolidinone derivative, S.L.- 25.1188 ((S)-5-methoxy-methyl-3-[6-(4,4,4-tri-fluoro butoxy)- benzo[d]isoxazol-3-yl]-oxazolidin-2-one), belonging to a new generation of selective and reversible M.A.O.-B inhibitors was developed and showed in vitro a high selectivity for M.A.O.B. [1]. The aim of this study was to characterize [{sup 11}C]S.L.- 25.1188 as radioligand for in vivo PET examination of M.A.O.-B. Materials and methods. - PET studies of the brain distribution were carried out in male Papio anubis baboons. Selectivity and reversibility of [{sup 11}C]S.L.-25.1188 binding for M.A.O.-B was assessed by pre-treatment or displacement experiments (30 min before and after tracer injection, respectively) using reference ligands for M.A.O.-B (deprenyl: 2 mg/kg i.v. and lazabemide: 0.5 mg/kg i.v.) or by displacement experiments using unlabelled S.L.-25.1188 (1 mg/kg, i.v., 30 min after tracer injection). Distribution volume (D.V.) was calculated using 2-tissue-compartment model. The saturable binding following pre-treatment with deprenyl was considered as the specific binding. Results. - After injection, [1{sup 1C}]S.L.-25.1188 presents a rapid phase of distribution in blood (about 5 min), followed by a elimination with T1/2 of 75 min. The Blood to plasma concentration ratio was constant during the experimentation (0.9 {+-} .04) consistent with a similar kinetic of [{sup 11}C]S.L.- 25.1188 in both blood and plasma. Metabolism analysis showed that [{sup 11}C]S.L.-25.1188 is stable in vivo. In the brain, uptake in different areas was

  5. The Effects of Wiki-based Recursive Process Writing on Chinese Narrative Essays for Chinese as a Second Language (CSL) Students in Singapore

    OpenAIRE

    Chee Kuen Chin; Cheng Gong; Boon Pei Tay

    2015-01-01

    This paper reports on the effects of using wiki-based process writing in Singapore’s Chinese as a Second Language (CSL) scenarios. A group of 32 Secondary 1 (Seventh Grade) students (“Students”) received various forms of online scaffolding at different steps of the writing process over two years. A whole set of teaching materials on 45 writing skills was developed and uploaded to the Wiki platform through five recursive cycles. In each cycle, the students were encouraged to app...

  6. BRIC in the Backyard: Brazil’s Economic Rise and What it Means for the United States (CSL Issue Paper, Volume 14-11, July 2011)

    Science.gov (United States)

    2011-07-01

    seeking expanded trade ties with developing countries, as well as a strengthening of the Common Market of the South – Mercosul ( Mercosur in Spanish...Brazil believes that strengthening Mercosur would grant South America better conditions to fight for more balanced and fairer trade with other regions...Department of State Country Background Notes –Brazil,” http://www.state.gov/r/pa/ei/ bgn/35640.htm (accessed April 10, 2011) CSL-3 world.12 In 2008 Mercosur

  7. Energetic and Entropic Contributions to the Landau–de Gennes Potential for Gay–Berne Models of Liquid Crystals

    Directory of Open Access Journals (Sweden)

    Bhaskar Gupta

    2013-03-01

    Full Text Available The Landau–de Gennes theory provides a successful macroscopic description of nematics. Cornerstone of this theory is a phenomenological expression for the effective free energy as a function of the orientational order parameter. Here, we show how such a macroscopic Landau–de Gennes free energy can systematically be constructed for a microscopic model of liquid crystals formed by interacting mesogens. For the specific example of the Gay–Berne model, we obtain an enhanced free energy that reduces to the familiar Landau–de Gennes expression in the limit of weak ordering. By carefully separating energetic and entropic contributions to the free energy, our approach reconciles the two traditional views on the isotropic–nematic transition of Maier–Saupe and Onsager, attributing the driving mechanism to attractive interactions and entropic effects, respectively.

  8. Temperature-dependent study of isotropic-nematic transition for a Gay-Berne fluid using density-functional theory

    Energy Technology Data Exchange (ETDEWEB)

    Singh, Ram Chandra [Department of Physics, Hindustan Institute of Technology, 32, 34 Knowledge Park-III, Greater Noida-201306, UP (India)

    2007-09-19

    We have used the density-functional theory to study the effect of varying temperature on the isotropic-nematic transition of a fluid of molecules interacting via the Gay-Berne intermolecular potential. The nematic phase is found to be stable with respect to isotropic phase in the temperature range 0.80{<=}T*{<=}1.25. Pair correlation functions needed as input information in density-functional theory is calculated using the Percus-Yevick integral equation theory. We find that the density-functional theory is good for studying the isotropic-nematic transition in molecular fluids if the values of the pair-correlation functions in the isotropic phase are known accurately. We have also compared our results with computer simulation results wherever they are available.

  9. 2016 Consensus statement on return to sport from the First World Congress in Sports Physical Therapy, Bern

    DEFF Research Database (Denmark)

    Ardern, Clare L; Glasgow, Philip; Schneiders, Anthony

    2016-01-01

    Deciding when to return to sport after injury is complex and multifactorial-an exercise in risk management. Return to sport decisions are made every day by clinicians, athletes and coaches, ideally in a collaborative way. The purpose of this consensus statement was to present and synthesise current...... sense of individual factors that may influence the athlete's return to sport, and the Strategic Assessment of Risk and Risk Tolerance framework may help decision-makers synthesise information to make an optimal return to sport decision. Research evidence to support return to sport decisions in clinical...... evidence to make recommendations for return to sport decision-making, clinical practice and future research directions related to returning athletes to sport. A half day meeting was held in Bern, Switzerland, after the First World Congress in Sports Physical Therapy. 17 expert clinicians participated. 4...

  10. BERN INVENTORY OF TREATMENT GOALS: PART 1. Development and First Application of a Taxonomy of Treatment Goal Themes.

    Science.gov (United States)

    Grosse, Martin; Grawe, Klaus

    2002-03-01

    The taxonomy of treatment goal themes of the Bern Inventory of Treatment Goals (BIT-T) is presented. The taxonomy was developed using 1,031 treatment goals of 298 outpatients at a university clinic. A first version of the taxonomy was constructed by cluster-analyzing eo-occurrence values computed from categorizations made by 22 therapists. Iterative revisions after several rating trials resulted in BIT-T Version 3.1. Categories at the highest of three levels of abstraction are coping with specific problems and symptoms (P), interpersonal goals (I), well-being and functioning (W), existential issues (E), and personal growth (G). In (re-)coding an extended sample of outpatient treatment goals, the BIT-T proved to have a good interrater reliability, identified differences between diagnostic groups, and showed meaningful relations to standardized intake measures. Applications of the taxonomy for research and practice purposes as well as possible consequences of the obtained first results are discussed.

  11. Glass Formation of n-Butanol: Coarse-grained Molecular Dynamics Simulations Using Gay-Berne Potential Model

    Institute of Scientific and Technical Information of China (English)

    Gui-long Xie; Yong-hong Zhang; Shi-ping Huang

    2012-01-01

    Using coarse-grained molecular dynamics simulations based on Gay-Berne potential model,we have simulated the cooling process of liquid n-butanol.A new set of GB parameters are obtained by fitting the results of density functional theory calculations.The simulations are carried out in the range of 290-50 K with temperature decrements of 10 K.The cooling characteristics are determined on the basis of the variations of the density,the potential energy and orientational order parameter with temperature,whose slopes all show discontinuity.Both the radial distribution function curves and the second-rank orientational correlation function curves exhibit splitting in the second peak.Using the discontinuous change of these thermodynamic and structure properties,we obtain the glass transition at an estimate of temperature Tg=120±10 K,which is in good agreement with experimental results 110±1 K.

  12. The introduction of gas-powered busses in Berne; Die Einfuehrung von Gasbussen bei Bernmobil - Ein Erfahrungsbericht

    Energy Technology Data Exchange (ETDEWEB)

    Finger, D.; Kljun, N.; Keller, M.

    2008-07-01

    This report for the Swiss Federal Office of Energy (SFOE) discusses the experience gained from the operation of biogas-powered buses in Berne, Switzerland. The fleet conversion from diesel-engined buses to new vehicles powered by biogas from the city's wastewater treatment plant is discussed. Six operational aspects involved in the use of gas-powered buses in comparison with traditional diesel buses are examined and discussed. These include infrastructure adaptations, fuel and energy consumption, emissions and air-hygiene, operational changes, financial aspects and acceptance of the new vehicles both by operating personnel and the general public. Operational difficulties encountered after fire-damage to the gas filling equipment in the bus depot are noted. Fuel consumption is commented on and measurements made on emissions are discussed. The advantages and disadvantages of biogas busses in comparison with diesel busses are discussed.

  13. The new bern PET cyclotron, its research beam line, and the development of an innovative beam monitor detector

    Science.gov (United States)

    Braccini, Saverio

    2013-04-01

    The new Bern cyclotron laboratory aims at industrial radioisotope production for PET diagnostics and multidisciplinary research by means of a specifically conceived beam transfer line, terminated in a separate bunker. In this framework, an innovative beam monitor detector based on doped silica and optical fibres has been designed, constructed, and tested. Scintillation light produced by Ce and Sb doped silica fibres moving across the beam is measured, giving information on beam position, shape, and intensity. The doped fibres are coupled to commercial optical fibres, allowing the read-out of the signal far away from the radiation source. This general-purpose device can be easily adapted for any accelerator used in medical applications and is suitable either for low currents used in hadrontherapy or for currents up to a few μA for radioisotope production, as well as for both pulsed and continuous beams.

  14. The new bern PET cyclotron, its research beam line, and the development of an innovative beam monitor detector

    Energy Technology Data Exchange (ETDEWEB)

    Braccini, Saverio [Albert Einstein Center for Fundamental Physics, Laboratory for High Energy Physics (LHEP), University of Bern, Sidlerstrasse 5, CH-3012 Bern (Switzerland)

    2013-04-19

    The new Bern cyclotron laboratory aims at industrial radioisotope production for PET diagnostics and multidisciplinary research by means of a specifically conceived beam transfer line, terminated in a separate bunker. In this framework, an innovative beam monitor detector based on doped silica and optical fibres has been designed, constructed, and tested. Scintillation light produced by Ce and Sb doped silica fibres moving across the beam is measured, giving information on beam position, shape, and intensity. The doped fibres are coupled to commercial optical fibres, allowing the read-out of the signal far away from the radiation source. This general-purpose device can be easily adapted for any accelerator used in medical applications and is suitable either for low currents used in hadrontherapy or for currents up to a few {mu}A for radioisotope production, as well as for both pulsed and continuous beams.

  15. A novel derivative of decursin, CSL-32, blocks migration and production of inflammatory mediators and modulates PI3K and NF-κB activities in HT1080 cells.

    Science.gov (United States)

    Lee, Seung-Hee; Lee, Jee Hyun; Kim, Eun-Ju; Kim, Won-Jung; Suk, Kyoungho; Kim, Joo-Hwan; Song, Gyu Yong; Lee, Won-Ha

    2012-07-01

    Decursin and related coumarin compounds in herbal extracts have a number of biological activities against inflammation, angiogenesis and cancer. We have analysed a derivative of decursin (CSL-32) for activity against inflammatory activation of cancer cells, such as migration, invasion and expression of pro-inflammatory mediators. The human fibrosarcoma cell line, HT1080, was treated with TNFα (tumour necrosis factor α) in the presence or absence of CSL-32. The cellular responses and modification of signalling adapters were analysed with respect to the production of pro-inflammatory mediators, as also migration, adhesion and invasion. Treatment of HT1080 cells with CSL-32 inhibited their proliferation, without affecting cell viability, and TNFα-induced expression of pro-inflammatory mediators, such as MMP-9 (matrix metalloproteinase-9) and IL-8 (interleukin-8). CSL-32 also suppressed phosphorylation and degradation of IκB (inhibitory κB), phosphorylation of p65 subunit of NF-κB (nuclear factor-κB) and nuclear translocation of NF-κB, which are required for the expression of pro-inflammatory mediators. In addition, CSL-32 inhibited invasion and migration of HT1080 cells, as also cellular adhesion to fibronectin, an ECM (extracellular matrix) protein. CSL-32 treatment resulted in a dose-dependent inhibition of PI3K (phosphoinositide 3-kinase) activity, required for the cellular migration. The analyses show that CSL-32 inhibits processes associated with inflammation, such as the production of pro-inflammatory mediators, as well as adhesion, migration and invasion in HT1080 cells.

  16. Ambassadors of the Latin American and Carribean Countries accredited in Bern at ALICE experiment with Collaboration Spokesperson J. Schukraft and Non Member States Relations J. Ellis and J. Salicio Diez on 10 October 2006.

    CERN Multimedia

    Maximilien Brice

    2006-01-01

    Ambassadors of the Latin American and Carribean Countries accredited in Bern at ALICE experiment with Collaboration Spokesperson J. Schukraft and Non Member States Relations J. Ellis and J. Salicio Diez on 10 October 2006.

  17. Fritz-Peter Hager/Daniel Tröhler (Hrsg.): Neue Pestalozzi-Studien. Bd. 1: Anna Pestalozzis Tagebuch - Käte Silber: Anna Pestalozzi und der Frauenkreis um Pestalozzi. Bern/Stuttgart: Haupt 1993 [Rezension

    OpenAIRE

    Liedtke, Max

    1994-01-01

    Rezension von: Fritz-Peter Hager/Daniel Tröhler (Hrsg.): Neue Pestalozzi-Studien. Bd. 1: Anna Pestalozzis Tagebuch - Käte Silber: Anna Pestalozzi und der Frauenkreis um Pestalozzi. Bern/Stuttgart: Haupt 1993, 242 S.

  18. Clemens Diesbergen: Radikal-konstruktivistische Pädagogik als problematische Konstruktion. Eine Studie zum Radikalen Konstruktivismus und seiner Anwendung in der Pädagogik. Frankfurt a.M./Bern: Lang 1998. [Rezension

    OpenAIRE

    Benner, Dietrich

    1999-01-01

    Rezension von: Clemens Diesbergen: Radikal-konstruktivistische Pädagogik als problematische Konstruktion. Eine Studie zum Radikalen Konstruktivismus und seiner Anwendung in der Pädagogik. Frankfurt a.M./Bern: Lang 1998. 318 S.

  19. Ulrich Binder: Das Subjekt der Pädagogik - Die Pädagogik des Subjekts. Das Subjektdenken der theoretischen und der praktischen Pädagogik im Spiegel ihrer Zeitschriften. Bern: Haupt Verlag 2009. 630 S. [Rezension

    OpenAIRE

    Tenorth, Heinz-Elmar

    2011-01-01

    Rezension von: Ulrich Binder: Das Subjekt der Pädagogik - Die Pädagogik des Subjekts. Das Subjektdenken der theoretischen und der praktischen Pädagogik im Spiegel ihrer Zeitschriften. Bern: Haupt Verlag 2009. 630 S.

  20. The Effects of Wiki-based Recursive Process Writing on Chinese Narrative Essays for Chinese as a Second Language (CSL Students in Singapore

    Directory of Open Access Journals (Sweden)

    Chee Kuen Chin

    2015-01-01

    Full Text Available This paper reports on the effects of using wiki-based process writing in Singapore’s Chinese as a Second Language (CSL scenarios. A group of 32 Secondary 1 (Seventh Grade students (“Students” received various forms of online scaffolding at different steps of the writing process over two years. A whole set of teaching materials on 45 writing skills was developed and uploaded to the Wiki platform through five recursive cycles. In each cycle, the students were encouraged to apply skills they learned via Wiki platform in their writing and afterwards work as a team in the platform to peer-review each other’s first draft. With feedback received from peer revision, students proceeded to edit their first draft, focusing on the content of narratives and the appropriateness on their use of micro writing skills. The scaffolding decreased as the project progressed. Students’ pre-, mid- and post-writing tests were marked and compared. The authors analyzed the impact that the feedback in the process had towards the students’ overall writing performance. It was discovered that students' quality of written products was improved in general. It was also discovered that students benefited the most from giving remarks to their peers’ writing. The revision patterns of high, medium and low language ability students were also compared. It was found that the higher the language ability of the students, the more concerned they were with macro level for their revisions. ICT-mediated process writing has not garnered much attention in the field of CSL. The study hopes to contribute to the literature of ICTmediated writing instruction in the field of CSL.

  1. Scientific Opinion on the safety and efficacy of Lactobacillus acidophilus D2/CSL (Lactobacillus acidophilus) for laying hens

    OpenAIRE

    EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)

    2014-01-01

    Lactobacillus acidophilus D2/CSL is the trade name for a preparation of a strain of Lactobacillus acidophilus. EFSA was requested to re-evaluate the additive when used in feed for laying hens at a minimum dose of 1 × 109 CFU/kg feed and to assess the safety and efficacy of its use in water for drinking for the same species. The identity of L. acidophilus has been established and no resistance to clinically relevant antibiotics has been detected. The strain satisfies the requirements for the q...

  2. Effect of dietary supplementation with Lactobacillus acidophilus D2/CSL (CECT 4529) on caecum microbioma and productive performance in broiler chickens

    OpenAIRE

    De Cesare, Alessandra; Sirri, Federico; Manfreda, Gerardo; Moniaci, Paola; Giardini, Alberto; Zampiga, Marco; Meluzzi, Adele

    2017-01-01

    This study examines the effects of the dietary supplementation with Lactobacillus acidophilus D2/CSL (CECT 4529) (LA) on productive performances, incidence of foot pad dermatitis and caecum microbioma in broiler chickens. A total of 1,100 one-day old male Ross 308 chicks were divided into 2 groups of 16 replicates with 25 birds each and reared from 1–41 d. One group was fed a basal diet (CON) and the other group the same diet supplemented with LA. Caecum contents were collected from 4 selecte...

  3. 二宽度CSL代数与套代数的因子分解%Factorization of Width-two CSL Algebras and Nest Algebras

    Institute of Scientific and Technical Information of China (English)

    杨有龙; 吴艳

    2006-01-01

    In this paper, we show that the invertible operator T, which is a bounded linear functional on a separable Hilbert space H, could factor as T = US, where U is unitary and S belongs to width-two CSL algebra algψ (ψ=M∨N) when nest M or N is a countable nest, or S belongs to algψ-1 when nests M and N are countable nests. For the factorization of nest,we obtain that T factors as T = US where S ∈ DN-1 and U is unitary as N be a countable nest.

  4. 2016 Consensus statement on return to sport from the First World Congress in Sports Physical Therapy, Bern.

    Science.gov (United States)

    Ardern, Clare L; Glasgow, Philip; Schneiders, Anthony; Witvrouw, Erik; Clarsen, Benjamin; Cools, Ann; Gojanovic, Boris; Griffin, Steffan; Khan, Karim M; Moksnes, Håvard; Mutch, Stephen A; Phillips, Nicola; Reurink, Gustaaf; Sadler, Robin; Silbernagel, Karin Grävare; Thorborg, Kristian; Wangensteen, Arnlaug; Wilk, Kevin E; Bizzini, Mario

    2016-07-01

    Deciding when to return to sport after injury is complex and multifactorial-an exercise in risk management. Return to sport decisions are made every day by clinicians, athletes and coaches, ideally in a collaborative way. The purpose of this consensus statement was to present and synthesise current evidence to make recommendations for return to sport decision-making, clinical practice and future research directions related to returning athletes to sport. A half day meeting was held in Bern, Switzerland, after the First World Congress in Sports Physical Therapy. 17 expert clinicians participated. 4 main sections were initially agreed upon, then participants elected to join 1 of the 4 groups-each group focused on 1 section of the consensus statement. Participants in each group discussed and summarised the key issues for their section before the 17-member group met again for discussion to reach consensus on the content of the 4 sections. Return to sport is not a decision taken in isolation at the end of the recovery and rehabilitation process. Instead, return to sport should be viewed as a continuum, paralleled with recovery and rehabilitation. Biopsychosocial models may help the clinician make sense of individual factors that may influence the athlete's return to sport, and the Strategic Assessment of Risk and Risk Tolerance framework may help decision-makers synthesise information to make an optimal return to sport decision. Research evidence to support return to sport decisions in clinical practice is scarce. Future research should focus on a standardised approach to defining, measuring and reporting return to sport outcomes, and identifying valuable prognostic factors for returning to sport.

  5. Benefit of Problem-Based Learning for Psychosocial Medicine: first experiences at the medical faculty of berne

    Directory of Open Access Journals (Sweden)

    Laederach-Hofmann, Kurt

    2005-04-01

    Full Text Available Aim: Presentation of skills and knowledge of medical students in psychiatry or psychosocial medicine in basic study (year 1 to 3 after the introduction of a problem oriented learning curriculum at the Medical Faculty of Berne.Method: Description of the curriculum with the different teaching units, and the evaluation by means of formative tools used by students and tutors.Results: With reference to qualitative comparison students of the problem based learning track showed a better preparation of the different teaching units than did traditional students. Moreover, compared to classical teaching, students in problem based learning rated the commitment of the teachers higher. The formative results showed a better adherence to the teaching modules, a higher effort in self learning and a higher interest in psychological or psychiatric learning items.Discussion: The higher commitment of teachers and the explicit structuring of the teaching contents in psychiatry and psychosocial medicine showed positive effects in the learning strategy of students. Beside the fact that exams have been adapted to the new curriculum one can assume that the learning style has changed. This might be a result of the better learning environment in the new curriculum. However, there is not clear how and to what extent these changes will remain active until the final exams of the medical curriculum when psychosocial contents will be reexamined.Conclusions: The intense commitment of the teachers and the better structuring of the subject matter may lead to a better integration of psychosocial and psychiatric issues into the medical curriculum.

  6. From Beijing to Berne

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Starting relatively late, China is quickly catching up with other countries in copyright protection Since drafting its first domestic copyright law, it has taken China only a little over a decade to join the major international copyright conventions. Thi

  7. An in vivo comparison of the efficacy of CSL box jellyfish antivenom with antibodies raised against nematocyst-derived Chironex fleckeri venom.

    Science.gov (United States)

    Winter, Kelly L; Isbister, Geoffrey K; Jacoby, Tamara; Seymour, Jamie E; Hodgson, Wayne C

    2009-06-01

    Although CSL box jellyfish antivenom (AV) remains the primary treatment for Chironex fleckeri envenoming, there has been considerable debate regarding its clinical effectiveness. Animal studies have shown that AV is largely ineffective in preventing C. fleckeri-induced cardiovascular collapse. This study examined the effectiveness of CSL box jellyfish AV (ovine IgG), raised against 'milked' venom, and polyclonal rabbit IgG antibodies (Ab) raised against nematocyst-derived venom. A venom dose of 30microg/kg, i.v., which causes an initial presser response (34+/-5mmHg; n=7) followed by cardiovascular collapse, was used in all experiments. A bolus dose of AV (3000U/kg, i.v.) or Ab (12mg; i.e. an equivalent protein 'load' to 3000U/kg AV), administered 15min prior to a bolus dose of venom, did not significantly attenuate the effects of venom. The venom response was also not significantly attenuated when AV (3000U/kg) was given as a bolus dose 10-60min prior to venom infusion. However, when the venom was incubated with either AV (3000U/kg) or Ab (12mg) for 3h prior to infusion, the effect of the venom was almost abolished. The results of this study demonstrate that antibodies raised against both 'milked' and nematocyst-derived venom are able to neutralise the cardiovascular collapse produced by the venom. However, large amounts of AV are required and must be preincubated with the venom to be protective. This indicates a very rapid action of the toxin(s) and that AV is unlikely to be clinically effective because it cannot be administered early enough.

  8. Paradoxical effects of Auger electron-emitting (111)In-DTPA-NLS-CSL360 radioimmunoconjugates on hCD45(+) cells in the bone marrow and spleen of leukemia-engrafted NOD/SCID or NRG mice.

    Science.gov (United States)

    Bergstrom, Dane; Leyton, Jeffrey V; Zereshkian, Arman; Chan, Conrad; Cai, Zhongli; Reilly, Raymond M

    2016-10-01

    (111)In-DTPA-NLS-CSL360 radioimmunoconjugates (RIC) recognize the overexpression of the interleukin-3 receptor α-subchain (CD123) relative to the β-subchain (CD131) on leukemia stem cells (LSC). Our aim was to study Auger electron radioimmunotherapy (RIT) of acute myeloid leukemia (AML) with (111)In-DTPA-NLS-CSL360 in non-obese diabetic severe combined immunodeficiency (NOD/SCID) mice or NOD-Rag1(null)IL2rγ(null) (NRG) mice engrafted with CD123(+) human AML-5 cells. The toxicity of three doses of (111)In-DTPA-NLS-CSL360 (3.3-4.8MBq; 11-15μg each) injected i.v. every two weeks was studied in non-engrafted NOD/SCID or NRG mice pre-treated with 200cGy of γ-radiation required for AML engraftment. Engraftment efficiency of (1-5)×10(6) cells AML-5 cells inoculated i.v. into NOD/SCID or NRG mice was assessed by flow cytometric analysis for human CD45(+) (hCD45(+)) cells in the bone marrow (BM) and spleen. AML-5 engrafted mice were treated with two or three doses (3.7MBq; 10μg each) every two weeks of (111)In-DTPA-NLS-CSL360, non-specific (111)In-DTPA-NLS-hIgG, unlabeled CSL360 (10μg) or normal saline. The percentage of hCD45(+) cells in the BM and spleen were measured at one week after completion of treatment. (111)In-DTPA-NLS-CSL360 in combination with 200cGy of γ-radiation caused an initial transient decrease in body weight in NOD/SCID but not in NRG mice. There were no hematological, liver or kidney toxicities. The spleen exhibited 13-fold lower engraftment efficiency than the BM in NOD/SCID mice inoculated with 1×10(6) cells but both organs were highly (>85%) engrafted in NRG mice. Unexpectedly, (111)In-DTPA-NLS-CSL360 or non-specific (111)In-DTPA-NLS-hIgG caused a paradoxical 1.5-fold increase (PDTPA-NLS-CSL360 reduced hCD45(+) cells in the spleen by 3.0-fold compared to (111)In-DTPA-NLS-hIgG (P=0.0015) but the proportion of hCD45(+) cells was not significantly different than in normal saline treated mice. Unlabeled CSL360 decreased the percentage of hCD45

  9. Professor Darleane C. Hoffman, Senior Advisor & Charter Director Seaborg Institute for Transactinium Science Livermore, California and Dr Marvin Hoffman accompanied by Professor Heinz Gäggeler, University of Bern and Paul Scherrer Institut Villigen.

    CERN Multimedia

    Maximilien Brice

    2001-01-01

    Photo 02 : Visit of Professor Darleane C. Hoffman, Senior Advisor & Charter Director, Seaborg Institute for Transactinium Science, Livermore, California with (from left to right) Dr Mats Lindroos, ISOLDE Technical Coordinator; Professor Heinz Gäggeler, University of Bern and Paul Scherrer Institute Villigen, and Dr Marvin Hoffman.

  10. Modelling and mapping of spatial differentiated impacts of nitrogen input to ecosystems within the framework of the UNECE-Convention of Air Pollution Prevention. Part II. The model BERN - assessment of vegetation change and biodiversity; Modellierung und Kartierung raeumlich differenzierter Wirkungen von Stickstoffeintraegen in Oekosysteme im Rahmen der UNECE-Luftreinhaltekonvention. Teilbericht II. Das BERN-Modell - ein Bewertungsmodell fuer die oberirdische Biodiversitaet

    Energy Technology Data Exchange (ETDEWEB)

    Nagel, Hans-Dieter; Schlutow, Angela; Kraft, Philipp; Scheuschner, Thomas; Weigelt-Kirchner, Regine [OEKO-DATA - Ecosystem Analysis and Environmental Data Management, Strausberg (Germany)

    2010-03-15

    Semi-natural ecosystems are exposed to high atmospheric deposition for decades. In contrary to sulphur deposition which could be significantly reduced due to international conventions on air pollution prevention during the last decades, deposition of both, reduced and oxidized nitrogen is still on a very high level in average 40 kg N ha{sup -1} yr{sup -1} in forest ecosystems in Germany. The FuE-Project ''Modelling and mapping of spatial differentiated impacts of nitrogen input to ecosystems within the framework of the UNECE - Convention of Air Pollution Prevention'' was jointly conducted by 4 partner institutions and studied impacts of atmospheric nitrogen deposition and climate change on physicochemical properties of forest soils, nutrient storage and nutrient export (Karlsruhe Research Centre, IMK-IFU) as well as biodiversity of vegetation (OEKO-DATA and Waldkundeinstitut Eberswalde) and soil organisms (Giessen University). Work carried out at OEKO-DATA initially concentrated on the development of the BERN-model. About 14 585 vegetation inventories from all over Germany and other 2 914 relevant inventories evaluated from neighboring countries were integrated in BERN database. With this model, the vegetation changes as a function of variations in the location conditions could be identified due to the implementation of the corresponding time series of geochemical and climate parameters from MoBiLE. A validation of the MoBiLE-BERN-coupling was carried out at Level II sites. From the dynamics of the vegetation development in the context of location changes could be derived critical loads and limits. Also the current regeneration potential as well as a harmonious natural balance of location factors could be determined. Likewise, the potential of danger to biodiversity and the livelihood opportunities of plant species or societies could be demonstrated. The most distinct dependence of biodiversity change could be detected on the alterations of

  11. 20th century changes in carbon isotopes and water-use efficiency: tree-ring-based evaluation of the CLM4.5 and LPX-Bern models

    Science.gov (United States)

    Keller, Kathrin M.; Lienert, Sebastian; Bozbiyik, Anil; Stocker, Thomas F.; Churakova (Sidorova), Olga V.; Frank, David C.; Klesse, Stefan; Koven, Charles D.; Leuenberger, Markus; Riley, William J.; Saurer, Matthias; Siegwolf, Rolf; Weigt, Rosemarie B.; Joos, Fortunat

    2017-05-01

    Measurements of the stable carbon isotope ratio (δ13C) on annual tree rings offer new opportunities to evaluate mechanisms of variations in photosynthesis and stomatal conductance under changing CO2 and climate conditions, especially in conjunction with process-based biogeochemical model simulations. The isotopic discrimination is indicative of the ratio between the CO2 partial pressure in the intercellular cavities and the atmosphere (ci/ca) and of the ratio of assimilation to stomatal conductance, termed intrinsic water-use efficiency (iWUE). We performed isotope-enabled simulations over the industrial period with the land biosphere module (CLM4.5) of the Community Earth System Model and the Land Surface Processes and Exchanges (LPX-Bern) dynamic global vegetation model. Results for C3 tree species show good agreement with a global compilation of δ13C measurements on leaves, though modeled 13C discrimination by C3 trees is smaller in arid regions than measured. A compilation of 76 tree-ring records, mainly from Europe, boreal Asia, and western North America, suggests on average small 20th century changes in isotopic discrimination and in ci/ca and an increase in iWUE of about 27 % since 1900. LPX-Bern results match these century-scale reconstructions, supporting the idea that the physiology of stomata has evolved to optimize trade-offs between carbon gain by assimilation and water loss by transpiration. In contrast, CLM4.5 simulates an increase in discrimination and in turn a change in iWUE that is almost twice as large as that revealed by the tree-ring data. Factorial simulations show that these changes are mainly in response to rising atmospheric CO2. The results suggest that the downregulation of ci/ca and of photosynthesis by nitrogen limitation is possibly too strong in the standard setup of CLM4.5 or that there may be problems associated with the implementation of conductance, assimilation, and related adjustment processes on long-term environmental

  12. Effect of dietary supplementation with Lactobacillus acidophilus D2/CSL (CECT 4529) on caecum microbioma and productive performance in broiler chickens.

    Science.gov (United States)

    De Cesare, Alessandra; Sirri, Federico; Manfreda, Gerardo; Moniaci, Paola; Giardini, Alberto; Zampiga, Marco; Meluzzi, Adele

    2017-01-01

    This study examines the effects of the dietary supplementation with Lactobacillus acidophilus D2/CSL (CECT 4529) (LA) on productive performances, incidence of foot pad dermatitis and caecum microbioma in broiler chickens. A total of 1,100 one-day old male Ross 308 chicks were divided into 2 groups of 16 replicates with 25 birds each and reared from 1-41 d. One group was fed a basal diet (CON) and the other group the same diet supplemented with LA. Caecum contents were collected from 4 selected birds at day one and 5 selected birds at the end of the rearing period. Then, they were submitted to DNA extraction and whole DNA shotgun metagenomic sequencing. Overall, the LA supplementation produced a significant beneficial effect on body weight gain between 15-28 d and improved feed conversion rate in the overall period. On the contrary, litter moisture, pH and incidence of the foot pad lesions were not affected by LA. Birds treated with LA showed a lower occurrence of pasty vent at both 14 and 28 d. At the end of the rearing period, Lachanospiraceae were significantly higher in LA birds in comparison to CON (17.07 vs 14.39%; P = 0.036). Moreover, Ruminococcus obeum, Clostridium clostridioforme, Roseburia intestinalis, Lachnospiraceae bacterium 14-2T and Coprococcus eutactus were significantly higher in LA birds in comparison to CON. The relative abundance of Lactobacillus acidophilus was comparable between LA and CON groups. However, a positive effect was observed in relation to the metabolic functions in the treated group, with particular reference to the higher abundance of β-glucosidase. In conclusion, the LA supplementation improved broiler productive performances and metabolic functions promoting animal health.

  13. District Heating using a gas-motor-driven heat pump - result checking; Erfolgskontrolle. Heizzentrale mit indirekter Gasmotor-Waermepumpe. Berufsschulen Bern-Lorraine

    Energy Technology Data Exchange (ETDEWEB)

    Eggen, B.; Lanz, S.

    2003-07-01

    This final report for the Swiss Federal Office of Energy presents the results of a project that evaluated the operation of a district heating scheme that supplies various school and college buildings, residential buildings and Berne's Botanical Gardens with heat. This pilot and demonstration system comprises an indirect gas motor heat pump with co-generation unit and an electrically-driven heat pump. In order to achieve a high performance ratio the co-generation unit was additionally equipped with a heat-recovery heat pump which condenses the waste gas and recovers radiation heat losses. The implementation of the district heating project was done in stages to meet annual heat demands of around 6'500 MWh. About 50% of these demands are met by the indirect gas motor heat pump. Figures are presented on the optimisation of heat utilisation from ground water which permitted an improvement in the total efficiency of the plant of around 30% compared with a conventional installation. The authors state that, with this installation, it could be demonstrated in an exemplary fashion that heat pumps can also be installed in existing, non-renovated buildings. In the planning of such heat pump systems they recommend that special attention be paid to the overall performance ratio, and that the rate of flow of the heat source and system temperatures be taken into account.

  14. On Removing Enterpriseˊs Names in Names of CSL Teams in Perspective of Fans Emotion%球迷情感视角下中超球队名称去企业化刍议

    Institute of Scientific and Technical Information of China (English)

    张文俊

    2015-01-01

    采用文献资料法对外籍联赛球队发展背景及中超球队名称的企业化现状进行分析梳理,试找出中超球队名称更迭的深层次原因,从球迷情感视角出发给出中超球队名称去企业化及球队命名建议。研究表明:中超球队名称去企业化有着未来发展的必然性;球队名称去企业化应不可忽视球迷的情感选择、驱动和调节因素。主要结论:中超球队应参考欧洲联赛球队名称命名方法,尽量使用中性化的名称;转变单一股权,形成多股东共同参与俱乐部股份;扎根球迷群体,强调球迷参与逐步建立并完善会员制俱乐部。%Using literature,the development background of foreign soccer league teams and the situation of CSL teams sponsored by enterprise were discussed. It suggested to remove sponsorˊs names and renew their names of CSL teams from the pespective of fans emotion. Researches showed that there is a necessity for benifit of CSL teams to remove the names of enterprise in the future,dur-ing that periods the fans emotion in choosing,driving and adjusting would not be neglected. It came to condusion that CSL teams should name their own names refering to European league teams;club share option should be consist of majors instead of minori-ties,clubs should focus on fan grows supporting and their involvement to better the membership system.

  15. BERNE-COPENHAGUE-MADRID-PARÍS-SANTIAGO: INTERPOLACIONES RELATIVISTAS, VARIACIONES CUÁNTICAS E IMPACTOS CÓSMICOS EN ALTAZOR (1919-1931

    Directory of Open Access Journals (Sweden)

    Scott Weintraub

    2010-04-01

    Full Text Available En este artículo para el número especial de Revista Chilena de Literatura que conmemora el bicentenario chileno, exploro múltiples conexiones literarias, científicas, y geográficas entre el poema Altazor de Vicente Huidobro y los contextos filosófico-científicos globales de las primeras décadas del siglo XX. Evalúo el impacto de una serie de caídas lingüísticas, críticas, alegóricas y gravitacionales en la trayectoria del "viaje en paracaídas" de Altazor, para volver a considerar, desde varias perspectivas críticas que tratan la "ilegible" y ambigua conclusión del poema, el impacto de un evento lingüístico en el campo de gravedad del poema. De esta manera, el artículo examina el imaginario científico que Altazor comparte con ciertos descubrimientos clave en la física teórica y experimental durante la primera parte del siglo XX, vinculando la escena poética vanguardista chilena y europea (Madrid-Paris-Santiago con los avances científicos de la época (Berne-Copenhague. Dicha indagación histórico-contextual con el cambio de paradigma involucrado en el universo cuántico-relativista -contemporáneo a la fecha de composición del poema- exige una exploración de las maneras en que Altazor qua texto poético marca el paso discursivo entre las cosmovisiones newtonianas y cuánticas. El campo semántico de Altazor, examinado con respecto a estas cuestiones cosmológicas, demuestra cómo el poema largo de Huidobro marca un evento lingüístico y cósmico que, no obstante, es sin horizonte de expectativa y así radicalmente heterogéneo en su naturaleza -faceta del poema que subraya el tipo de variaciones y flujos cuánticos cuyos "senderos" no se pueden predecir con certidumbre.In this article for the special issue of Revista Chilena de Literatura devoted to Chile 's bicentennial, I explore multiple literary, scientific, and geographic connections between Vicente Huidobro s poem Altazor and the global philosophical

  16. GPU-Accelerated Molecular Dynamics Simulation to Study Liquid Crystal Phase Transition Using Coarse-Grained Gay-Berne Anisotropic Potential.

    Directory of Open Access Journals (Sweden)

    Wenduo Chen

    Full Text Available Gay-Berne (GB potential is regarded as an accurate model in the simulation of anisotropic particles, especially for liquid crystal (LC mesogens. However, its computational complexity leads to an extremely time-consuming process for large systems. Here, we developed a GPU-accelerated molecular dynamics (MD simulation with coarse-grained GB potential implemented in GALAMOST package to investigate the LC phase transitions for mesogens in small molecules, main-chain or side-chain polymers. For identical mesogens in three different molecules, on cooling from fully isotropic melts, the small molecules form a single-domain smectic-B phase, while the main-chain LC polymers prefer a single-domain nematic phase as a result of connective restraints in neighboring mesogens. The phase transition of side-chain LC polymers undergoes a two-step process: nucleation of nematic islands and formation of multi-domain nematic texture. The particular behavior originates in the fact that the rotational orientation of the mesogenes is hindered by the polymer backbones. Both the global distribution and the local orientation of mesogens are critical for the phase transition of anisotropic particles. Furthermore, compared with the MD simulation in LAMMPS, our GPU-accelerated code is about 4 times faster than the GPU version of LAMMPS and at least 200 times faster than the CPU version of LAMMPS. This study clearly shows that GPU-accelerated MD simulation with GB potential in GALAMOST can efficiently handle systems with anisotropic particles and interactions, and accurately explore phase differences originated from molecular structures.

  17. ¿Qué hacer con el ángel? J. L. Borges y F. L. Bernárdez, dos formas de escribir la experiencia mística

    Directory of Open Access Journals (Sweden)

    Lucas Adur

    2015-06-01

    Full Text Available Este trabajo propone una lectura de dos textos de escritores argentinos, publicados casi contemporáneamente, El buque (1935 de Francisco Luis Bernárdez y “El acercamiento a Almotásim” (1936 de Jorge Luis Borges, que pueden considerarse como dos modos, diametralmente opuestos, de dar cuenta de una experiencia mística. Una “positiva”, que apuesta por un discurso conceptual y una “negativa” que opta por la alusión, la paradoja y el silencio. El poema de Bernárdez tiene en su centro una revelación mística, experimentada por el yo lírico, que es transmisible en términos discursivos y que implica una propuesta moral. En este sentido, puede pensarse que El buque es representativo de la estética sostenida por un grupo de poetas católicos que, apoyados en la teología escolástica, proponían que la literatura debía estar al servicio de la difusión del mensaje cristiano y del renacimiento espiritual del pueblo. Borges escribe una reseña de este poema y, meses después, “El acercamiento a Almotásim”, relato que puede leerse como una respuesta polémica a la forma de presentar la experiencia mística que propone el texto de Bernárdez. Frente al “decir excesivo” que atribuye al poeta católico, Borges subraya en su escritura la dimensión inefable, intransmisible que caracteriza para él a toda experiencia directa de lo trascendente.

  18. Lineage A Betacoronavirus NS2 Proteins and the Homologous Torovirus Berne pp1a Carboxy-Terminal Domain Are Phosphodiesterases That Antagonize Activation of RNase L.

    Science.gov (United States)

    Goldstein, Stephen A; Thornbrough, Joshua M; Zhang, Rong; Jha, Babal K; Li, Yize; Elliott, Ruth; Quiroz-Figueroa, Katherine; Chen, Annie I; Silverman, Robert H; Weiss, Susan R

    2017-03-01

    Viruses in the family Coronaviridae, within the order Nidovirales, are etiologic agents of a range of human and animal diseases, including both mild and severe respiratory diseases in humans. These viruses encode conserved replicase and structural proteins as well as more diverse accessory proteins, encoded in the 3' ends of their genomes, that often act as host cell antagonists. We previously showed that 2',5'-phosphodiesterases (2',5'-PDEs) encoded by the prototypical Betacoronavirus, mouse hepatitis virus (MHV), and by Middle East respiratory syndrome-associated coronavirus antagonize the oligoadenylate-RNase L (OAS-RNase L) pathway. Here we report that additional coronavirus superfamily members, including lineage A betacoronaviruses and toroviruses infecting both humans and animals, encode 2',5'-PDEs capable of antagonizing RNase L. We used a chimeric MHV system (MHV(Mut)) in which exogenous PDEs were expressed from an MHV backbone lacking the gene for a functional NS2 protein, the endogenous RNase L antagonist. With this system, we found that 2',5'-PDEs encoded by the human coronavirus HCoV-OC43 (OC43; an agent of the common cold), human enteric coronavirus (HECoV), equine coronavirus (ECoV), and equine torovirus Berne (BEV) are enzymatically active, rescue replication of MHV(Mut) in bone marrow-derived macrophages, and inhibit RNase L-mediated rRNA degradation in these cells. Additionally, PDEs encoded by OC43 and BEV rescue MHV(Mut) replication and restore pathogenesis in wild-type (WT) B6 mice. This finding expands the range of viruses known to encode antagonists of the potent OAS-RNase L antiviral pathway, highlighting its importance in a range of species as well as the selective pressures exerted on viruses to antagonize it.IMPORTANCE Viruses in the family Coronaviridae include important human and animal pathogens, including the recently emerged viruses severe acute respiratory syndrome-associated coronavirus (SARS-CoV) and Middle East respiratory

  19. 2015赛季中国足球超级联赛各球队攻防能力分析%An analysis of each team’s attack and defense ability in 2015 CSL

    Institute of Scientific and Technical Information of China (English)

    江瑞丽; 商祥; 徐晓阳

    2016-01-01

    运用文献资料、录像观察、数理统计以及RSR秩和比评价等研究方法,对2015赛季中超联赛各球队的攻防能力进行分析。结果表明:中超各参赛队实力有较大差距,根据RSR值分析结果划分为5个等级;2支降级球队与对手存在很大差距,在进攻能力上,进球指标与其他球队差异具有非常显著性差异(P<0.01),控球率以及角球次数等指标与对手差异显著(P<0.05);在防守能力上,抢断成功次数与对手差异高度显著(P<0.01),失球数指标与对手差异显著(P<0.05)。%Using the methods of literature review, video watching , mathematical statistics and RSR to analyze and estimate the attack and defense ability of each team in 2015 CSL games, and providing theoretical basis to improve the technique level in CSL. The results indicate that there are great different among teams. According to the RSR data, the teams are divided into five grades. There are extremely significant differences between the offensive capacity of two demotion teams and other teams, including goals (P<0.01), and there are significant differences between the offensive capacity of two demotion teams and other teams, including ball controlling percentage and corner kick times (P<0.05);There are extremely significant differences in the defensive capacity between Hengda and its adversaries including tackles success ratio(P<0.01).there are extremely significant differences in the defensive capacity between Hengda and its adversaries including goals against(P<0.01).

  20. MASCOT: a new mass-spectrometer facility dedicated to the analysis of cosmogenic noble gases (3He and 21Ne) from terrestrial samples (Institute of Geological Sciences - University of Bern, Switzerland).

    Science.gov (United States)

    Delunel, Romain; Enderli, Patrick; Jenni, Hans-Erich; Leya, Ingo; Schlunegger, Fritz

    2017-04-01

    In the past years, terrestrial cosmogenic nuclides have been successfully used for dating exposure history of landforms and measuring erosional processes on Earth's surface. In this context, quantifications of landscape change have mainly been accomplished through the use of radioactive cosmogenic nuclides such as 10Be and 26Al, but their application has generally been restricted to Quaternary time scales because of their relatively short half-lives. The results are 10Be and 26Al concentrations that are below the detection limit of available accelerator mass spectrometers if the samples have a Late Miocene or even a Pliocene age. Contrariwise, cosmogenic noble gases such as 3He and 21Ne do not experience any radioactive decay through time, which places these isotopes in an unbeatable position for measuring paleo-denudation rates preserved in detrital material even if the ages of these deposits are up to 10 Ma and even older. These isotopes are thus keys for assessing the interplays between tectonic, climate and surface processes involved in the long-term evolution of mountain belts. Here we report the technical specifications of a noble gas analytical system that we have developed and set up at the Institute of Geological Sciences of the University of Bern, Switzerland, with the motivations to get dates and rates of erosion processes from the measurement of cosmogenic noble gases (3He and 21Ne) concentrations from terrestrial samples. This new facility, hosted at the Institute of Geological Sciences of the University of Bern, combines a MAP215-50 mass spectrometer fitted with a new high-sensitivity channel electron multiplier with an all-metal extraction and purification line. This later system thus comprises: (i) a double vacuum resistance furnace loaded by a 22-samples carrousel, (ii) three in-vacuo crushers (iii) an ultra high vacuum pumping system (<10-8 mbar) composed of turbo-molecular, ion-getter pumps and backed by a scroll pump, (iv) the line itself made

  1. Beckhoff照明控制让音乐剧《伯尔尼奇迹》大放异彩%Beckhoff Lighting Control for the Musical,“DasWunder von Bern” (The Miracle of Bern)

    Institute of Scientific and Technical Information of China (English)

    德国倍福自动化有限公司

    2016-01-01

    The new theaterlocated in Hamburg, Germany, "StageTheater an der Elbe", open to the public in December 2014, and the musical "Das Wunder von Bern"(The Miracle of Bern) premiered in the theater. That is the first theater inHamburgbuild by musical production company StageEntertainment and a new benchmark is set for advanced stage equipment in the world of classical musicals.Lighting, audio and special effects play a more important role in modern musicals as well as the music, songs, dance routines, stage design and costumes, far more than in classical drama and opera performances. In addition to the main lighting console, a standby independent lighting control systemreferred to Scenestoreis equippedfor rehearsal or emergency lighting.Scenestore is controlled by a Beckhoff CX5010 Embedded PC with DMX terminals and I/O modules for controllingdistributed sensors and actuators.%位于德国汉堡的易北河河畔新舞台剧院于2014年12月正式对公众开放,音乐剧《伯尔尼的奇迹》在该剧场进行了首演。这是舞台娱乐公司 Stage Entertainment在汉堡港打造的第一座新剧院,在世界经典音乐剧中为先进的舞台设备设立了新标杆。除了音乐、歌曲、舞蹈动作、舞台设计和服装之外,灯光、音响和特效在现代音乐剧中也发挥着重要作用,远超过在古典戏剧与歌剧表演中的作用。除了主照明控制台之外,还有第二套独立的照明控制系统(被称为Scenestore),用于彩排或在出现故障时用作应急照明。Scenestore通过一台连接DMX端子模块的倍福CX5010嵌入式控制器控制,其它 I/O模块用于控制分布式传感器和执行器。

  2. Analysis of Attack and Defense Ability of Each Team and CompetitionPatter in 2015 CSL%2015赛季中超联赛CSL各球队攻防实力对比与竞争格局分析

    Institute of Scientific and Technical Information of China (English)

    江瑞丽; 赵鲁南; 王朝信

    2016-01-01

    In the report, the methods of literature review, video watching, TOPSIS and RSR were used to analyze and overall merit the attack and defense ability in 2015CSL games,dialysis Chinese football competition patter.The results indicated that in today's our country the football landscape pattern not changed, taking over the world the sport in HengDa team;World sport strength pattern is still not balanced, according to the RSR data, there are three levels;there are extremely significant differences between the offensive capacity of three levels teams ,including shooting times(P<0.01),and there are significant differences between the offensive capacity of three levels teams,including goals,tackles the success rate,pass the threat ball time and corner kick times (P<0.05);there are extremely significant differences in the defensive capacity including goals against(P<0.01).there are extremely significant differences in the defensive capacity including fouls times and save the ball success rate (P<0.01). Attack and defense ability are balanced and strength can acquire good achievement,in contrast,it is not satisfactory in CSL ranks.%运用文献资料、录像观察、TOPSIS以及RSR秩和比评价等方法,对2015赛季中超各球队攻防指标进行分析并综合评价,探析中超联赛的竞争格局,研究结果:当今中国足球格局没有发生变化,恒大继续夺冠;中国足球实力格局仍不平衡,各参赛队在综合攻防实力上可分为3个等级;在进攻能力上,3个等级球队在射门次数指标上差异具有非常显著性(P<0.01),进球、控球率、传威胁球次数以及角球次数等指标差异具有显著性(P<0.05);在防守能力上,失球数差异具有高度显著性(P<0.01),犯规、扑救成功率等指标差异具有显著性( P<0.05)。中超联赛竞争格局表现在攻守能力较强且较均衡的球队在联赛中取得较好的成绩,而攻守不平衡的球队在联赛中的排名不理想。

  3. Kaposi's Sarcoma-Associated Herpesvirus Rta Tetramers Make High-Affinity Interactions with Repetitive DNA Elements in the Mta Promoter To Stimulate DNA Binding of RBP-Jk/CSL ▿ †

    Science.gov (United States)

    Palmeri, Diana; Carroll, Kyla Driscoll; Gonzalez-Lopez, Olga; Lukac, David M.

    2011-01-01

    Kaposi's sarcoma-associated herpesvirus (KSHV; also known as human herpesvirus 8 [HHV-8]) is the etiologic agent of Kaposi's sarcoma (KS) and lymphoproliferative diseases. We previously demonstrated that the KSHV lytic switch protein Rta stimulates DNA binding of the cellular RBP-Jk/CSL protein, the nuclear component of the Notch pathway, on Rta target promoters. In the current study, we define the promoter requirements for formation of transcriptionally productive Rta/RBP-Jk/DNA complexes. We show that highly pure Rta footprints 7 copies of a previously undescribed repetitive element in the promoter of the essential KSHV Mta gene. We have termed this element the “CANT repeat.” CANT repeats are found on both strands of DNA and have a consensus sequence of ANTGTAACANT(A/T)(A/T)T. We demonstrate that Rta tetramers make high-affinity interactions (i.e., nM) with 64 bp of the Mta promoter but not single CANT units. The number of CANT repeats, their presence in palindromes, and their positions relative to the RBP-Jk binding site determine the optimal target for Rta stimulation of RBP-Jk DNA binding and formation of ternary Rta/RBP-Jk/DNA complexes. DNA binding and tetramerization mutants of Rta fail to stimulate RBP-Jk DNA binding. Our chromatin immunoprecipitation assays show that RBP-Jk DNA binding is broadly, but selectively, stimulated across the entire KSHV genome during reactivation. We propose a model in which tetramerization of Rta allows it to straddle RBP-Jk and contact repeat units on both sides of RBP-Jk. Our study integrates high-affinity Rta DNA binding with the requirement for a cellular transcription factor in Rta transactivation. PMID:21880753

  4. BKW-FMB: Focus on solar power; In Topform: die BKW FMB Energie AG - Mitten in Bern: Sonnenstrom im Fokus - In Partnerschaft mit der Juvent SA: viel Wind im Jura - Wasserkraft Aarberg: Wasserkraft - oekologisch zertifiziert

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    This collection of three short articles present four examples of installations using renewable forms of energy that are operated by the Bernese power utility BKW-FMB in Switzerland. Brief details are given on the company, one of the largest electricity utilities in Switzerland. The first article deals with the photovoltaics (PV) installations on the roof of the new national soccer stadium in Berne and one of the oldest Swiss PV-installations on Mont-Soleil in the Jura mountains. Also covered are the efforts made by the utility and its partners in the area of marketing the power under the trade name '1 to 1 energy'. Information for the general public is provided in visitor centres and also by the solar-powered boat on the Lake of Bienne. A further article deals with wind power from the Mont-Crosin Site in the Jura mountains. The third article describes a hydro-electric power station on the river Aare, which, thanks to measures taken in the ecological area, carries the 'Naturemade Star' label for the power it produces.

  5. The Marquis de Condorcet goes to Bern

    DEFF Research Database (Denmark)

    Bochsler, Daniel

    2010-01-01

    JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about...

  6. The Bern Infinitesimal Bubble Chamber (BIBC)

    CERN Multimedia

    CERN PhotoLab

    1977-01-01

    The chamber body was machined from a block of aluminium. The visible volume was cylindrical with 65 mm diameter and 35 mm depth. It was filled with propane or freon. It was meant as vertex detector in the search of short-lived particles. It was also used with in-line holography resulting in 8 µm bubble size and 9 cm depth of the field. See E. Ramseyer, B. Hahn and E. Hugentobler, Nucl. Instrum. Methods 201 (1982) 335.

  7. The Marquis de Condorcet goes to Bern

    DEFF Research Database (Denmark)

    Bochsler, Daniel

    2010-01-01

    JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about...

  8. 教师认知视角下的职前汉语教师语法教学信念研究%Grammar Teaching Beliefs Held by Pre-service CSL Teachers: A Study from the Perspective of Teacher Cognition

    Institute of Scientific and Technical Information of China (English)

    汲传波; 刘芳芳

    2012-01-01

    The study is conducted with the participation of pre-service CSL their grammar teaching beliefs. On the whole, data from the questionnaire show CSL teachers not only accept the general principles of communicative language Teachers to explore that the pre-service teaching, but also treasure the value of traditional of grammar teaching. The two individual differences, major contexts and teaching experiences, all make no significant difference in their beliefs about grammar teaching. However, the difference is only identified in their inductive beliefs from the dimension of gender. Based upon these findings, the implications for Chinese as a Second Language teacher education is discussed at the end of the paper.%本研究以职前汉语教师为调查对象,研究了他们的语法教学信念特点。结果表明,总体而言,他们既接受交际语法教学的原则,又肯定传统语法教学的价值。就个体差异而言,职前汉语教师的本科专业背景、有无教学经验在六类语法教学信念上不存在显著差异;不同性别的职前汉语教师仅在归纳信念上存在显著差异。基于这些发现,本文讨论了该调查对国际汉语教师培养的启示。

  9. Regression Analysis of Each Team’s Technical Indica-tors and Competition Results of CSL in Season ;2014%2014赛季CSL各球队比赛技术指标与比赛成绩的逐步回归分析

    Institute of Scientific and Technical Information of China (English)

    王朝信; 陈翀; 康金明

    2015-01-01

    采用文献资料法、录像观察法以及数理统计法等研究方法,对2014赛季CSL16支球队240场比赛的20项常规技术指标与比赛积分进行统计,并按照比赛技术指标(自变量)对比赛积分(因变量)的大小进行逐步回归分析,研究结果显示:进入逐步回归方程的相关比赛技术指标的依次顺序是控球率、进球数与失球数。另外,根据2014赛季CSL各球队比赛积分的实际情况,将16支球队划分为4个层次,对处于不同层次的球队进行Kruskal-Wallis检验,发现不同层次球队的控球率的 Asymp. Sig.=0.0330.05、进球数的Asymp. Sig.=0.12>0.05、失球数的 Asymp. Sig.=0.019 0. 05 , Asymp. Sig. of the goal number equals 0. 12 > 0. 05, Asymp. Sig. of the conceding rate equals 0. 019 <0. 05, Asymp. Sig. of the competition scores equals 0. 019 <0. 05. For conceding number and score indicators,the re-sults of these two tests both show that P<0. 05,which im-plies that teams of different levels are greatly different in conceding number and competition scores.

  10. Model checking conditional CSL for continuous-time Markov chains

    DEFF Research Database (Denmark)

    Gao, Yang; Xu, Ming; Zhan, Naijun;

    2013-01-01

    In this paper, we consider the model-checking problem of continuous-time Markov chains (CTMCs) with respect to conditional logic. To the end, we extend Continuous Stochastic Logic introduced in Aziz et al. (2000) [1] to Conditional Continuous Stochastic Logic (CCSL) by introducing a conditional...

  11. Urban hybrid : Bern-Ausserhollingen, Sveits / Inga Raukas, Toomas Tammis

    Index Scriptorium Estoniae

    Raukas, Inga, 1967-

    1999-01-01

    Arhitektuuriagentuuri (Inga Raukas, Toomas Tammis, Tarmo Teedumäe, Eero Endjärv) tööst noorte arhitektide konkursil Europan 5 "Uued elamismaastikud, liikumine ja lähedus". 26.-29. IX 1999 Genfis toimunud rahvusvahelisest foorumist, millel Eestist osalesid Tõnu Laigu ja Inga Raukas. 5 ill

  12. Urban hybrid : Bern-Ausserhollingen, Sveits / Inga Raukas, Toomas Tammis

    Index Scriptorium Estoniae

    Raukas, Inga, 1967-

    1999-01-01

    Arhitektuuriagentuuri (Inga Raukas, Toomas Tammis, Tarmo Teedumäe, Eero Endjärv) tööst noorte arhitektide konkursil Europan 5 "Uued elamismaastikud, liikumine ja lähedus". 26.-29. IX 1999 Genfis toimunud rahvusvahelisest foorumist, millel Eestist osalesid Tõnu Laigu ja Inga Raukas. 5 ill

  13. 75 FR 21164 - Safety Zone; Neuse River, New Bern, NC

    Science.gov (United States)

    2010-04-23

    ... and Interference with Constitutionally Protected Property Rights. Civil Justice Reform This rule meets... this section. (2) Persons or vessels requiring entry into or passage through any portion of the safety...

  14. Nonequilibrium molecular dynamics simulation of steady shear flows of Gay-Berne fluids; Gay-Berne ryutai no teijo sendan nagare ni taisuru hiheiko bunshi dorikigaku simulation

    Energy Technology Data Exchange (ETDEWEB)

    Mori, N.; Nakamura, K. [Osaka University, Osaka (Japan)

    1998-03-15

    Numerical simulation was carried out by a nonequilibrium molecular dynamics method to clarify the system structure and rhelogical properties in the steady shear flow of the isotropic and nematic phases of liquid crystalline molecules. The F-GB potential (Lennard-Jones type that represents the model potential of liquid crystalline molecules and that has the dependency of orientation) that has both attractive force and repulsive force as the potential between molecules and the WCA-GB potential in which only repulsive force is considered were used. In an equilibrium system, it was known that the attractive force between molecules facilitates the phase transition of isotropic phase to liquid crystalline phase. In a shear flow, four systems between the isotropic and nematic phases were calculated, and the effect of the shear flow on each system was clarified. Moreover, the effect of the attractive force between the molecules in isotropic and nematic phases was investigated. The result showed that the attractive force between molecules influences the orientation order parameter of the system at a low shear rate. The degree of influence at that time differs in isotropic and nematic phases. 21 refs., 7 figs.

  15. Chinese Five Year Plans: An Economic Catalyst? (CSL Issue Paper, Volume 11-11, July 2011)

    Science.gov (United States)

    2011-07-01

    December 1955): 189, in JSTOR (accessed April 14, 2011). 3. Ibid. 4. Ibid. 5. China.org, http://www.china.org (accessed April 13, 2011). LTC(P) Troy...Accountability under Authoritarianism,” Political Research Quarterly 60, no. 3 (Fall 2007): 380, in JSTOR (accessed April 14, 2011). 8. Ibid. 9. Ibid. 10. Shu Y...Ma, “China’s Privatization: From Gradualism to Shock Therapy?,” Asian Survey 48, no. 2 (March/April 2008): 199, in JSTOR (accessed April 14, 2011

  16. Effects of verapamil and CSL antivenom on Chironex fleckeri (box-jellyfish) induced mortality.

    Science.gov (United States)

    Bloom, D A; Burnett, J W; Hebel, J R; Alderslade, P

    1999-11-01

    Ovine antivenom prolonged survival in mice challenged with intravenous Chironex fleckeri venom over a limited dose range. Verapamil enhanced the beneficial effect of ovine antivenom. This data suggests that there may be an, as yet undefined, optimal antivenom dose for humans and that verapamil, used in combination with antivenom is an effective agent.

  17. USSOUTHCOM Interagency Meeting on Food Security (CSL Issue Paper, Volume 11-09, July 2009)

    Science.gov (United States)

    2009-07-01

    fear" for the people, for which food security is an essential component. The most common definition of food security is one established by the UNFAO...34 Food security exists when all people, at all times, have physical, social, and economic access to sufficient, safe, and nutritious food to meet...affecting national and regional security issues such as food security . The issues of food availability, food access and utilization, the situation of

  18. BFKL Pomeron and Bern-Dixon-Smirnov amplitudes in N=4 SUSY

    Energy Technology Data Exchange (ETDEWEB)

    Lipatov, L.N. [Petersburg Nuclear Physics Institute (Russian Federation)]|[Hamburg Univ. (Germany). 2. Inst. fuer Theoretische Physik

    2008-10-15

    We review the theoretical approaches for investigations of the high energy hadron-hadron scattering in the Regge kinematics. It is demonstrated, that the gluon in QCD is reggeized and the Pomeron is a composite state of the reggeized gluons. Remarkable properties of the BFKL equation for the Pomeron wave function in QCD and supersymmetric gauge theories are outlined. Due to the AdS/CFT correspondence the BFKL Pomeron is equivalent to the reggeized graviton in the extended N=4 SUSY. The properties of the maximal transcendentality and integrability are realized in this model. The BDS multi-gluon scattering amplitudes are investigated in the Regge limit. They do not contain the Mandelstam cuts and are not valid beyond one loop. It is shown, that the hamiltonian for these composite states coincides with the hamiltonian of an integrable open Heisenberg spin chain. (orig.)

  19. Subcutaneous immunoglobulin for maintenance treatment in chronic inflammatory demyelinating polyneuropathy (The PATH Study): study protocol for a randomized controlled trial

    OpenAIRE

    van Schaik, Ivo N; van Geloven, Nan; Bril, Vera; Hartung, Hans-Peter; Lewis, Richard A.; Sobue, Gen; Lawo, John-Philip; Mielke, Orell; Cornblath, David R.; Merkies, Ingemar S. J.; ,

    2016-01-01

    Background Subcutaneous administration of Ig (SCIg) has gained popularity as an alternative route of administration but has never been rigorously examined in chronic inflammatory demyelinating polyneuropathy (CIDP). Methods/design The primary objective of the PATH study (Polyneuropathy and Treatment with Hizentra) is to determine the efficacy of two different doses of SCIg IgPro20 (0.2 g/kg bw or 0.4 g/kg bw) in a 24-week maintenance treatment of CIDP in comparison to placebo. The primary eff...

  20. The Crosshole Sonic Logging (CSL) Measurement System to Measure the Quality of Physical Model of Bored Pile

    Science.gov (United States)

    Sibit, Denniswara; Handayani, Gunawan

    2016-08-01

    The crosshole sonic logging measurement to measure the quality of bored piles is presented in this paper. The development of crosshole measurement system on physical bored pile modeling was carried out. The diameter of the concrete model was around 1 m and the height of the model was 1 m. In the model two holes were constructed to simulate the crosshole measurement system in the field. The two holes were filled with water and then two transducers were lowered in the holes. The transducers were built from audio speaker and microphone and they were sealed by rubber material so that the transducers were water proof. The speaker transducer acted as transmitter and the microphone transducer acted as receiver. The acoustic wave transmitted from the speaker penetrated in the concrete material and received by receiver. By analyzing the waveform arrived at the receiver by means of datalogger we determine the condition the concrete pile i.e. whether there were cavities in the concrete etc.

  1. Is Brazil Actually Ready to be a World Economic Power? (CSL Issue Paper, Volume 13-11, July 2011)

    Science.gov (United States)

    2011-07-01

    Brazil, Porto Brasil : Economic Sectors, http://www.brasil.gov.br/sobre/economy/economy-sectors/agriculture-and-cattle- raising-agropecuaria (accessed...April 15, 2011); Federal Government of Brazil, “Porto Brasil : Federal Government Budget,” http://www.brasil.gov.br/sobre/ brazil/government/federal

  2. Climate Change, Adaptation and Security in Central America and the Caribbean (CSL Issue Paper, Volume 3-11)

    Science.gov (United States)

    2011-03-01

    DoS’ Regional Environmental Hub, and other regional partners, in the organization of roundtables, conferences and train -the-trainer workshops in...technology and knowledge: assist with data gathering • Training and education: impart knowledge and expertise • Protection of coastal areas and...safeguard lives, restore infrastructure 2. In that regard, the Deutsche Gesellchaft für Technische Zusammenarbeil considers education as a key pre-condition

  3. China’s Pursuit of Africa’s Natural Resources, (CSL Issue Paper, Volume 1-09, June 2009)

    Science.gov (United States)

    2009-06-01

    the local African labor pool. An estimated 750,000 Chinese have relocated to Africa in the last 10 years (African Politics Portal , 2008). This African...energy-security-asem-beijing-financial-crisis (accessed December 5, 2008). African Politics Portal . 2008. Top Ten Misconceptions about Chinese...say.html?ca_tid=46 (accessed December 5, 2008). 13 Genetic Memory. 2007. “China fund Rebuilding Angola.” http://geneticmemory.org/ joomla /index2.php

  4. Late Alpine to recent thick-skinned tectonics of the central Swiss Molasse Basin, Canton of Bern, Switzerland

    Science.gov (United States)

    Mock, Samuel; Allenbach, Robin; Wehrens, Philip; Reynolds, Lance; Kurmann-Matzenauer, Eva; Michael, Salomè; Herwegh, Marco

    2017-04-01

    The Swiss Molasse Basin (SMB) forms part of the North Alpine Foreland Basin. It is a typical peripheral foreland basin, which developed in Paleogene and Neogene times in response to flexural bending of the European lithosphere induced by the orogenic loading of the advancing Alpine thrust wedge. The tectonics of the SMB and the role of Paleozoic and Mesozoic structures are still poorly understood. It is widely accepted that during the main deformation phase of the Jura fold-and-thrust belt, the SMB was riding piggy-back above a major detachment horizon situated within Triassic evaporites. In recent years it has been observed that the Jura fold-and-thrust belt is today deforming in a thick-skinned tectonic style. As for the western and central SMB, most authors still argue in favor of a classical foreland type, thin-skinned style of deformation. Based on the geological 3D modeling of seismic interpretations, we present new insights into the structural configuration of the central SMB. Revised and new interpretations of 2D reflection seismic data from the 1960s to the 1980s reveal a major strike-slip fault zone affecting not only the Mesozoic and Cenozoic cover, but also the crystalline basement beneath. The fault zone reactivated late Paleozoic synsedimentary normal faults bounding a Permo-Carboniferous trough. Basement-involved thrusting observed in the southern part of the SMB seems to be controlled by the presence of slightly inverted Permo-Carboniferous troughs as well. These observations, combined with a compiled structural map and the distribution of recent earthquake hypocenters suggest a late stage, NNW-SSE directed, compressional thick-skinned and strike-slip dominated tectonic activity of the central SMB, post-dating the main deformation phase of the Jura fold-and-thrust belt. This still ongoing deformation might be related to the slab rollback of the European plate and the associated lower crustal delamination as recently suggested by Singer et al. (2014). References: Singer, J., Diehl, T., Husen, S., Kissling, E., Duretz, T., 2014. Alpine lithosphere slab rollback causing lower crustal seismicity in northern foreland. Earth Planet. Sci. Lett. 397, 42-56. doi:10.1016/j.epsl.2014.04.002

  5. Rezension zu: Thomas Rhyner, Bea Zumwald (Hg.: Coole Mädchen – starke Jungs. Bern: Haupt Verlag 2008

    Directory of Open Access Journals (Sweden)

    Hilde von Balluseck

    2009-03-01

    Full Text Available In dem Buch der Schweizer Herausgeber/-innen sind viele Beiträge mit großem Engagement, jedoch wenig analytischem Durchdringungsvermögen zusammengestellt. Es ist eine Hilfe für diejenigen Lehrkräfte, die noch nie etwas von Gleichstellungsbemühungen in der Schule gehört haben. Für alle anderen bringt es wenig Neues und führt intellektuell eher in die Vergangenheit als zukunftsweisend zu sein.

  6. Battered Children and Child Abuse. Highlights and Recommendations of the CIOMS/WHO Conference (Berne, Switzerland, December 1985).

    Science.gov (United States)

    Bankowski, Z., Ed.; Carballo, M., Ed.

    This document provides highlights and recommendations of a conference on battered children and child abuse sponsored by the Council for International Organizations of Medical Sciences (CIOMS) and the World Health Organization (WHO). In a discussion of the nature of the child abuse problem, the history of child maltreatment is briefly reviewed and…

  7. "De Genes y Gentes". Libro del Académico Jaime Eduardo Bernál Villegas

    Directory of Open Access Journals (Sweden)

    Francisco Núñez

    2002-08-01

    Full Text Available

    La amistad con Jaime Eduardo Bernal es, además de un permanente disfrute de sus ocurrencias y de su fino humor, un activo ejercicio intelectual. Todavía me asombra su inagotable capacidad de sorprender.

    Es hombre emprendedor, que con tesón ha culminado exitosamente cada uno de los numerosos proyectos que se ha impuesto.

    Así como lo vemos gozar con cada nueva idea, he sido testigo del entusiasmo con que las desarrolla y de su satisfacción cuando las hace realidad.

    Es un médico profundamente compasivo que busca transmitir la armonía que debe existir entre la aplicación del conocimiento, los hallazgos de la ciencia y un ejercicio médico con hondo sentido humanitario.

    Desde que lo conozco (y ello data de los claustros universitarios, ha trabajado infatigablemente por la humanización de la medicina: no es el investigador frío, que se yergue sobre la neutralidad moral de la ciencia o la invoca para apartarse de su compromiso hipocrático. Tiene muy claros los límites que le impone la moral natural y por consiguiente la ética médica Iniciando el año de 1980, recién llegado de Newcastle, Inglaterra, donde acababa de recibir su PhD en Genética Humana después de largos años de especialización, ingresó a la sala de profesores del departamento de Pediatría de la Universidad Javeriana, donde solíamos reunirnos a debatir los casos clínicos de nuestros pacientes. Jaime Eduardo entró calmadamente, en su mano un maletín y en él una libreta que llamaba “el libro de las Ideas” y así estaba rotulada; se hallaban consignados allí muchos de los que habrían de convertirse en proyectos de investigación y más tarde en exitosas investigaciones y publicaciones.

    Ocupó un escritorio y me dijo “vamos a ver qué se puede hacer, vengo a pensar…“. No había transcurrido mucho tiempo cuando sus ideas y alrededor de ellas un pequeño grupo de investigadores ya nos habían desalojado de nuestra sala de profesores; meses después ocupó un área aledaña al laboratorio clínico del hospital de San Ignacio que, al poco tiempo, fue también insuficiente para albergarlo, con todas sus ideas y proyectos en vigoroso desarrollo; se percibía allí una actividad permanente, llena del entusiasmo que caracteriza cada sueño que Bernal quiere hacer real...

  8. Strategic Minerals: Is China’s Consumption a Threat to United States Security? (CSL Issue Paper, Volume 7-11, July 2011)

    Science.gov (United States)

    2011-07-01

    varied. Roman access to the tin deposits of Cornwall provided the critical alloy to produce resilient bronze weapons. Access to the New World and... tungsten , REEs, tin, antimony and zinc, all of which it has exported. In 2002 mineral imports and exports accounted for nearly 20% of China’s total

  9. Making Riflemen from Mud: Restoring the Army’s Culture of Irregular Warfare (CSL Student Issue Paper, Volume S01-07, Jul 2007)

    Science.gov (United States)

    2007-07-01

    September 1899, Matthew Batson Papers, 1898-1900, U.S. Army Mili- tary History Institute, OCLC 4910883. 4 Ibid. See also Philippine Scouts Heritage...1899, Mathew Batson Papers, 1898-1900, U.S. Army Military History Institute, OCLC 4910883. PSHS, The Philippine Scouts, pp. 1-. Ibid., p. 1...in his division’s area in the Philippines. See memoir of service, Matthew Batson Papers, 1898-1900, U.S. Army Military History Institute, OCLC 4

  10. CSL encodes a leucine-rich-repeat protein implicated in red/violet light signaling to the circadian clock in Chlamydomonas.

    Directory of Open Access Journals (Sweden)

    Ayumi Kinoshita

    2017-03-01

    Full Text Available The green alga Chlamydomonas reinhardtii shows various light responses in behavior and physiology. One such photoresponse is the circadian clock, which can be reset by external light signals to entrain its oscillation to daily environmental cycles. In a previous report, we suggested that a light-induced degradation of the clock protein ROC15 is a trigger to reset the circadian clock in Chlamydomonas. However, light signaling pathways of this process remained unclear. Here, we screened for mutants that show abnormal ROC15 diurnal rhythms, including the light-induced protein degradation at dawn, using a luciferase fusion reporter. In one mutant, ROC15 degradation and phase resetting of the circadian clock by light were impaired. Interestingly, the impairments were observed in response to red and violet light, but not to blue light. We revealed that an uncharacterized gene encoding a protein similar to RAS-signaling-related leucine-rich repeat (LRR proteins is responsible for the mutant phenotypes. Our results indicate that a previously uncharacterized red/violet light signaling pathway is involved in the phase resetting of circadian clock in Chlamydomonas.

  11. La calidad total en bases de datos españolas: estudio de la tasa de error en las bases del CSlC

    OpenAIRE

    Herrero Solana, Víctor

    1997-01-01

    The quality of products and services is the buzzword of the 90's, specially in the information retrieval field. This article analyzes de quality level of three Spanish databases developed by the Council for Scientific Research : lCYT, ISOC and lME. The variable studied is the error rate, an objective indicator for the quality measurement. Finally, the results are compared to international standards.

    La calidad de productos y servicios es uno de los temas en boga de la prese...

  12. CSL encodes a leucine-rich-repeat protein implicated in red/violet light signaling to the circadian clock in Chlamydomonas

    Science.gov (United States)

    Kinoshita, Ayumi; Niwa, Yoshimi; Onai, Kiyoshi; Fukuzawa, Hideya; Ishiura, Masahiro

    2017-01-01

    The green alga Chlamydomonas reinhardtii shows various light responses in behavior and physiology. One such photoresponse is the circadian clock, which can be reset by external light signals to entrain its oscillation to daily environmental cycles. In a previous report, we suggested that a light-induced degradation of the clock protein ROC15 is a trigger to reset the circadian clock in Chlamydomonas. However, light signaling pathways of this process remained unclear. Here, we screened for mutants that show abnormal ROC15 diurnal rhythms, including the light-induced protein degradation at dawn, using a luciferase fusion reporter. In one mutant, ROC15 degradation and phase resetting of the circadian clock by light were impaired. Interestingly, the impairments were observed in response to red and violet light, but not to blue light. We revealed that an uncharacterized gene encoding a protein similar to RAS-signaling-related leucine-rich repeat (LRR) proteins is responsible for the mutant phenotypes. Our results indicate that a previously uncharacterized red/violet light signaling pathway is involved in the phase resetting of circadian clock in Chlamydomonas. PMID:28333924

  13. When is it acceptable to kill a strictly protected carnivore : Exploring the legal constraints on wildlife management within Europe's Bern Convention

    NARCIS (Netherlands)

    Linnell, John; Trouwborst, Arie; Fleurke, Floor

    2017-01-01

    As wolf populations expand across Europe, many countries face challenges in finding ways to address the concerns of some elements among the rural stakeholders who are being asked to share their landscapes with wolves for the first time in several generations. In these recovery landscapes, wolves are

  14. Water nuisance and road safety : paper presented to Session II of 1978 OECD Symposium on Road Drainage, Berne, Switzerland, 22-24 May, 1978.

    NARCIS (Netherlands)

    Welleman, A.G.

    1978-01-01

    Factors that may contribute to accidents on wet road surfaces (reduced general visibility, glare, invisibility of markings and reduction of tyre/road surface forces) are discussed in particular the latter. Measures for counteracting water nuisance (cutting grooves, small transverse discharge channel

  15. Self-diffusion in the non-Newtonian regime of shearing liquid crystal model systems based on the Gay-Berne potential

    Energy Technology Data Exchange (ETDEWEB)

    Sarman, Sten, E-mail: sarman@ownit.nu; Wang, Yong-Lei; Laaksonen, Aatto [Arrhenius Laboratory, Department of Materials and Environmental Chemistry, Stockholm University, 106 91 Stockholm (Sweden)

    2016-02-07

    The self-diffusion coefficients of nematic phases of various model systems consisting of regular convex calamitic and discotic ellipsoids and non-convex bodies such as bent-core molecules and soft ellipsoid strings have been obtained as functions of the shear rate in a shear flow. Then the self-diffusion coefficient is a second rank tensor with three different diagonal components and two off-diagonal components. These coefficients were found to be determined by a combination of two mechanisms, which previously have been found to govern the self-diffusion of shearing isotropic liquids, namely, (i) shear alignment enhancing the diffusion in the direction parallel to the streamlines and hindering the diffusion in the perpendicular directions and (ii) the distortion of the shell structure in the liquid whereby a molecule more readily can escape from a surrounding shell of nearest neighbors, so that the mobility increases in every direction. Thus, the diffusion parallel to the streamlines always increases with the shear rate since these mechanisms cooperate in this direction. In the perpendicular directions, these mechanisms counteract each other so that the behaviour becomes less regular. In the case of the nematic phases of the calamitic and discotic ellipsoids and of the bent core molecules, mechanism (ii) prevails so that the diffusion coefficients increase. However, the diffusion coefficients of the soft ellipsoid strings decrease in the direction of the velocity gradient because the broadsides of these molecules are oriented perpendicularly to this direction due the shear alignment (i). The cross coupling coefficient relating a gradient of tracer particles in the direction of the velocity gradient and their flow in the direction of the streamlines is negative and rather large, whereas the other coupling coefficient relating a gradient in the direction of the streamlines and a flow in the direction of the velocity gradient is very small.

  16. Implication of“Hengda”on the Professional Development of CSL%广州“恒大”亚冠夺冠对中超俱乐部职业化发展的启示

    Institute of Scientific and Technical Information of China (English)

    张蕾

    2014-01-01

    The article focuses on analyzing professional management approach which leads to the victory in international competitions abroad . Summed accountability and separating the reward in place, the strict execution and advanced football training philosophy is an important factor in cast Evergrande Football Club Professionalism. And on this basis, pointed out that the weakening of the Super League administrative color management to improve the company's Super independence, stable financing channels, strengthen the club capital strength, enhance the level of competition and football career awareness in order to accelerate the pace of reform in professional football clubs.%文章着重从职业化管理方法分析了恒大近年来能在国际、国内比赛中取得胜利的原因。总结出权责分明、政企分开、奖赏到位、执行力严格以及先进的足球训练理念是推动恒大足球俱乐部职业化发展的重要因素。在此基础上指出,弱化中超联赛管理的行政色彩,提高中超公司的独立性、稳定融资渠道,增强俱乐部资本实力、提升竞赛水平和足球职业意识才能加快足球俱乐部职业化改革的步伐。

  17. 汉语作为第二语言的声调认知发展模拟%Simulating Mandarin tone acquisition by CSL learners who are native English speakers

    Institute of Scientific and Technical Information of China (English)

    陈默

    2011-01-01

    A growing tree-structured self-organizing feature map network was developed to simulate the acquisition of Mandarin tones by native English speakers.This network has a dynamic network construction and capacity that is better than the traditional Kohonen self-organizing feature map.This network also more effectively preserves the global topology mapping than early dynamic tree-like maps.Simulations of the acquisition of Mandarin tones are consistent with experimental results.These show the dynamic developmental process of Mandarin tones.The results show that self-organization is an important mechanism for tone emergence and that tone feature teaching is important for Mandarin tone-teaching strategies.%该文提出了一个动态的生长型树型自组织特征映射网络,用以模拟英语母语者汉语声调的认知发展。该网络既克服了传统的Kohonen自组织特征映射网络的固定网络结构限制以及容量有限性,又克服了其他类似动态网络的较弱的拓扑映射特性,可以较好地模拟英语母语者汉语声调认知的发展。模拟结果跟实验结果呈现出非常好的一致性,既证明了行为实验中汉语声调的动态发展过程,也为汉语声调认知的机制研究提供了机理上的解释。

  18. Model Checking Algorithms for CTMDPs

    DEFF Research Database (Denmark)

    Buchholz, Peter; Hahn, Ernst Moritz; Hermanns, Holger

    2011-01-01

    Continuous Stochastic Logic (CSL) can be interpreted over continuoustime Markov decision processes (CTMDPs) to specify quantitative properties of stochastic systems that allow some external control. Model checking CSL formulae over CTMDPs requires then the computation of optimal control strategie...

  19. Model Checking Algorithms for CTMDPs

    DEFF Research Database (Denmark)

    Buchholz, Peter; Hahn, Ernst Moritz; Hermanns, Holger

    2011-01-01

    Continuous Stochastic Logic (CSL) can be interpreted over continuoustime Markov decision processes (CTMDPs) to specify quantitative properties of stochastic systems that allow some external control. Model checking CSL formulae over CTMDPs requires then the computation of optimal control strategie...

  20. Institutional Logics and Community Service-Learning in Higher Education

    Science.gov (United States)

    Taylor, Alison; Kahlke, Renate

    2017-01-01

    This paper explores how community service-learning (CSL) participants negotiate competing institutional logics in Canadian higher education. Drawing theoretically from new institutionalism and work on institutional logics, we consider how CSL has developed in Canadian universities and how participants discuss CSL in relation to other dominant…

  1. Community Service Learning: One School's Story.

    Science.gov (United States)

    Kelliher, Margaret F.

    1993-01-01

    Describes community service learning (CSL) programs at Pottenger School, Springfield (Massachusetts). The kindergarten through grade-12 school, a literature-based whole-language school, integrates CSL into the curriculum through writing about student experiences. CSL projects have included feeding the homeless, corresponding with a soldier, and…

  2. Functional genomic analysis supports conservation of function among cellulose synthase-like a gene family members and suggests diverse roles of mannans in plants

    DEFF Research Database (Denmark)

    Liepman, Aaron H; Nairn, C Joseph; Willats, William G T

    2007-01-01

    , the CslA genes are members of extended multigene families; however, it is not known whether all CslA proteins are glucomannan synthases. CslA proteins from diverse land plant species, including representatives of the mono- and dicotyledonous angiosperms, gymnosperms, and bryophytes, were produced...

  3. Geneviève Fabry, Ilse Logie y Pablo Decock (eds.), Los imaginarios apocalípticos en la literatura hispanoamericana contemporánea : Bern, Peter Lang, 2010, 472 páginas

    OpenAIRE

    Lépori, Roberto [UNESP

    2010-01-01

    Durante el bienio 2007-2008 se sucedieron en las universidades belgas de Gante y Lovaina la Nueva dos seminarios doctorales y un congreso internacional enmarcados en un proyecto de investigación cuyo principal objetivo era revisar los imaginarios apocalípticos en la literatura hispanoamericana contemporánea. El resultado es esta selección de veinticinco conferencias y ponencias que irradian aún rastros de su filiación oral y de la ardua tarea de argumentar sobre y a partir de una lengua ajena...

  4. Subglacial bedrock topography of an active mountain glacier in a high Alpine setting - insights from high resolution 3D cosmic-muon radiography of the Eiger glacier (Bern, Central Alps, Switzerland)

    Science.gov (United States)

    Mair, David; Lechmann, Alessandro; Nishiyama, Ryuichi; Schlunegger, Fritz; Ariga, Akitaka; Ariga, Tomoko; Scampoli, Paola; Vladymyrov, Mykhailo; Ereditato, Antonio

    2016-04-01

    Bedrock topography and therefore the spatial-altitudinal distribution of ice thickness constrain the ice flow as well as the erosional mechanisms of glaciers. Although the processes by which glaciers have shaped modern and past landscapes have been well investigated, little information is still available about the shape of the bedrock beneath active glaciers in steep Alpine cirques. Here, we we apply the cosmic-muon radiography technology, which uses nuclear emulsion detectors for imaging the bedrock surface. This method should provide information on the bedrock topography beneath a glacier and related ice thicknesses and subglacial meltwater pathways. We apply this technology to the cirque of the Eiger glacier, situated on the western flank of Eiger mountain, Central Swiss Alps. The Eiger glacier originates on the western flank of the Eiger at 3700 m a.s.l., from where it stretches along 2.6 km to the current elevation at 2300 m a.s.l.. The glacier consists of a concave cirque bordered by >40° steep flanks, thereby utilizing weaknesses within the fabric of the bedrock such as folds, joints and foliations. The middle reach hosts a bedrock ridge where glacier diffluence occurs. The lower reaches of the glacier are characterized by several transverse crevasses, while the terminal lobe hosts multiple longitudinal crevasses. A basal till and lateral margins border the ice flow along the lowermost reach. While subglacial erosion in the cirque has probably been accomplished by plucking and abrasion where the glacier might be cold-based, sub glacial melt water might have contributed to bedrock sculpting farther downslope where the ice flow is constrained by bedrock. Overdeepening of some tens of meters is expected in the upper reach of the glacier, which is quite common in cirques (Cook & Swift, 2012). Contrariwise, we expect several tens of meters-deep bedrock excavations (characterized by concave curvatures of bedrock surface) at the site of ice diffluence. The next step of our research will be identifying the morphometry of the bedrock beneath the glacier (e.g., slope angles, curvatures and changes thereof, width to depth ratios and roughness) based on the muon radiography. We will combine these data with information about the fabric of the bedrock to determine how the bedrock properties have conditioned the erosional processes in this steep glacial cirque. References: Cook, S.J., & Swift, D.A., 2012. Subglacial basins: Their origin and importance in glacial systems and landscapes. Earth-Science Reviews 115, 332-372.

  5. Godard, philosophe. Vincent Berne, Identité et invisibilité du cinéma. Le vide constitutif de l’image dans Hélas pour moi de J.-L. Godard

    OpenAIRE

    Albera, François

    2014-01-01

    Jean-Luc Godard « commerce » avec la philosophie depuis pas mal de temps. On connaît la séquence de Vivre sa vie où Brice Parain dialogue avec Nana (Anna Karina) : la séquence d’une dizaine de minutes est sur YouTube (en diverses langues). Guère lu de nos jours, l’auteur des Recherches sur la nature et les fonctions du langage du Logos platonicien, de Sur la dialectique et de Petite métaphysique de la parole – qui avait commencé par un Essai sur la misère humaine en 1934 –, doit peut-être sa ...

  6. Critical service learning in community health nursing: enhancing access to cardiac health screening.

    Science.gov (United States)

    Gillis, Angela; Mac Lellan, Marian A

    2013-04-23

    Critical service learning (CSL) offers promise for preparing community health nursing students to be advocates for social justice and social change. The purpose of this article is to describe a community based CSL project designed to provide cardiac health screening to an underserviced population, wherein nursing's role in social justice is integrated into nursing practice. First, the relationship between social justice and CSL is explored. Then, the CSL approach is examined and differentiated from the traditional service learning models frequently observed in the nursing curriculum. The CSL project is described and the learning requisites, objectives, requirements, and project outcomes are outlined. While not a panacea for system reform, CSL offers nursing students avenues for learning about social justice and understanding the social conditions that underlie health inequalities. Nurse educators may benefit from the new strategies for incorporating social justice into nursing curriculum; this paper suggests that CSL offers one possibility.

  7. Grain boundaries analysis in polycrystalline silicon by TEM

    Energy Technology Data Exchange (ETDEWEB)

    Komninou, F.; Karakostas, T.; Bleris, G.L.; Economou, N.A. (Aristoteles University, Thessaloniki (Greece))

    1982-01-01

    Polycrystalline Si interfaces were examined within the CSL's approach. The rotation relationship of every bicrystal has been analyzed with the technique of the instrumental system and the small angle description has been used for the CSL characterization. The most frequently occuring descriptions are CSL' ..sigma..=3 coherent and incoherent twins, the later being microscopically coherent. Cases of multiple boundaries were also examined and interelations were found between low or high angle boundaries for CSL's with ..sigma..>3. A special case of interest is a ..sigma..=39 CSL which is formed from a combination of ..sigma..=13b and ..sigma..=3 and is a triclinic CSL lacking 180/sup 0/ rotational operations. The results presented indicate that for polycrystalline Si the CSL model could be used in describing the interfaces occuring.

  8. Chickpea (Cicer arietinum steep liquor as a leavening agent: Effect on dough rheology and sensory properties of bread

    Directory of Open Access Journals (Sweden)

    Saad Ahmed M.

    2015-01-01

    Full Text Available Dough fermentation is one of the oldest process in food technologies. It has been recently intensively studied for its impact on the sensory, structural, nutritional and shelf life properties of leavened baked products. The goals of this work were to investigate chickpea steep liquor (CSL as a dough-leavening agent and to study the effect of CSL on the dough rheology and sensory properties of leavened bread. CSL was prepared by submerging chickpea seeds in boiled distilled water (1:2, w/v for 24 h at 37оC, and then obtained liquor was filtered and freeze-dried to obtain CSL. The addition of CSL to wheat flour (WF brought changes in the dough mixing behavior as measured by the farinograph. An increase in the farinograph water absorption of WF dough was observed when 4.5% CSL and 1.5% yeast was added, while arrival time was not affected. Addition of CSL to the dough at a content of 4.5, 9.0 and 13.5 g CSL/300 g WF caused an increase in dough stability. The CSL addition also increased mechanical tolerance index, dough weakening and mixing time. Dough development time for all blends was higher than the control (1.2-1.5 min, while between the CSL samples no significant difference was observed. The loaf weight slightly increased from 146.2 g for control to 152.2 g for CSL fermented bread, whereas the loaf volume and specific volume of CSL-fermented bread were lower than the control. The combination of yeast and CSL increased the acceptability of bread with the increasing level of both leavening agents’. The results show that CSL could be used as an alternative to yeast for syngas fermentation. On the other hand, CLS is rich in nutrients and lower in cost compared to yeast.

  9. Docking and Molecular Dynamics Simulations of Celastrol Binding to p23

    Energy Technology Data Exchange (ETDEWEB)

    Han, Sang Hwa [Seoul National University, Seoul (Korea, Republic of)

    2012-01-15

    Blind docking simulations identified a binding site of CSL-COO{sup -} on p23. Further structural refinement by MD simulations revealed an extensive hydrogen bonding network between the ligand and nearby residues including Arg88 and Thr90. Hydrophobic interaction is implied between the hydrocarbon skeleton and the hydrophobic surface of the protein. The complex stayed stable during 20 ns of MD simulation suggesting that the binding is strong in both docking and MD simulations. Celastrol (CSL), a quinone methide triterpenoid from thunder god vine, is a natural product with high antiinflammatory and anti-cancer potential. One of CSL's major targets is the Hsp90 chaperoning system and its inhibition by CSL results in destabilization of the Hsp90 client proteins involved in inflammation and cancer. Early reports suggest that CSL binds to the N-terminal domain of Hsp90 to interfere with the Hsp90-Cdc37 association. Later it was demonstrated that CSL reacts with cysteine residues of Cdc37 causing aggregation of Cdc37. Recently Chadli et al. showed that CSL induces fibrillization of p23, an Hsp90 co-chaperone that is specific for steroid receptors. Although CSL can react with cysteine residues of p23, non-covalent association is implicated in the fibrillization because reduced CSL is equally effective. The authors identified the amino acid residues whose NMR signals were perturbed upon CSL-COO{sup -} binding. Structure of the p23-CSL complex has not been determined, however. We previously performed docking and molecular dynamics simulations to identify the CSL binding site of Erk2 and found that CSL inhibits FceRI signaling by blocking the Erk2's ATP binding site. A similar strategy was employed in this study to model the structure of the p23-CSL complex.

  10. Enhancement of light extraction efficiency of vertical LED with patterned graphene as current spreading layer

    Science.gov (United States)

    Singh, Sumitra; Sai Nandini, Annam Deepthi; Pal, Suchandan; Dhanavantri, Chenna

    2016-01-01

    In this paper we report an optimised pattern of surface textured graphene current spreading layer (CSL) for the enhancement of light extraction efficiency (LEE) in InGaN/GaN vertical light emitting diodes (V-LEDs). It is found that by texturing graphene surface LEE improves drastically. This improvement is attributed to better current spreading of graphene and increased random and multiple scattering of light through textured surfaces. Simulation results illustrate that V-LEDs with surface textured (hexagonal pattern) ITO as CSL shows threefold improvement in light extraction efficiency compared to V-LEDs with no surface texturing on ITO CSL. Further, LEE of V-LEDs having patterned graphene CSL is compared with that for indium tin oxide (ITO) CSL. V-LEDs with optimised hexagonal patterning on graphene CSL shows 13.42% enhancement of LEE compared to that of LED with hexagonal patterning on ITO surface.

  11. EFFECT OF CORN STEEP LIQUOR CONCENTRATION ON GLYCEROL PRODUCTION AND KINETIC ANALYSIS OF GLYCEROL FERMENTATION%玉米浆浓度对甘油发酵的影响及动力学

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    In batch cultures of Candida krusei, the effect of corn steep liquor (CSL) concentration was investigated. The result showed that glycerol yield was greatly affected by CSL concentration. Higher glycerol yield was attained when the initial CSL concentration in the medium was 9 g.L-1. The fermentation kinetics were studied and the parameters for cell growth, maintenance, and glycerol production were obtained. Material balance revealed by product formation during the growth phase and suggested a fed-batch culture strategy.

  12. An Exact Chiral Spin Liquid with Non-Abelian Anyons

    Energy Technology Data Exchange (ETDEWEB)

    Yao, Hong

    2010-04-06

    We establish the existence of a chiral spin liquid (CSL) as the exact ground state of the Kitaev model on a decorated honeycomb lattice, which is obtained by replacing each site in the familiar honeycomb lattice with a triangle. The CSL state spontaneously breaks time reversal symmetry but preserves other symmetries. There are two topologically distinct CSLs separated by a quantum critical point. Interestingly, vortex excitations in the topologically nontrivial (Chern number {+-}1) CSL obey non-Abelian statistics.

  13. The cellulose synthase superfamily in fully sequenced plants and algae

    Directory of Open Access Journals (Sweden)

    Xu Ying

    2009-07-01

    Full Text Available Abstract Background The cellulose synthase superfamily has been classified into nine cellulose synthase-like (Csl families and one cellulose synthase (CesA family. The Csl families have been proposed to be involved in the synthesis of the backbones of hemicelluloses of plant cell walls. With 17 plant and algal genomes fully sequenced, we sought to conduct a genome-wide and systematic investigation of this superfamily through in-depth phylogenetic analyses. Results A single-copy gene is found in the six chlorophyte green algae, which is most closely related to the CslA and CslC families that are present in the seven land plants investigated in our analyses. Six proteins from poplar, grape and sorghum form a distinct family (CslJ, providing further support for the conclusions from two recent studies. CslB/E/G/H/J families have evolved significantly more rapidly than their widely distributed relatives, and tend to have intragenomic duplications, in particular in the grape genome. Conclusion Our data suggest that the CslA and CslC families originated through an ancient gene duplication event in land plants. We speculate that the single-copy Csl gene in green algae may encode a mannan synthase. We confirm that the rest of the Csl families have a different evolutionary origin than CslA and CslC, and have proposed a model for the divergence order among them. Our study provides new insights about the evolution of this important gene family in plants.

  14. RAM-induced Allostery Facilitates Assembly of a Notch Pathway Active Transcription Complex

    Energy Technology Data Exchange (ETDEWEB)

    Friedmann, David R.; Wilson, Jeffrey J.; Kovall, Rhett A. (UCIN-MED)

    2008-07-09

    The Notch pathway is a conserved cell-to-cell signaling mechanism, in which extracellular signals are transduced into transcriptional outputs through the nuclear effector CSL. CSL is converted from a repressor to an activator through the formation of the CSL-NotchIC-Mastermind ternary complex. The RAM (RBP-J associated molecule) domain of NotchIC avidly interacts with CSL; however, its role in assembly of the CSL-NotchIC-Mastermind ternary complex is not understood. Here we provide a comprehensive thermodynamic, structural, and biochemical analysis of the RAM-CSL interaction for components from both mouse and worm. Our binding data show that RAM and CSL form a high affinity complex in the presence or absence of DNA. Our structural studies reveal a striking distal conformational change in CSL upon RAM binding, which creates a docking site for Mastermind to bind to the complex. Finally, we show that the addition of a RAM peptide in trans facilitates formation of the CSL-NotchIC-Mastermind ternary complex in vitro.

  15. RAM-Induced Allostery Facilitates Assembly of a Notch Pathway Active Transcription Complex

    Energy Technology Data Exchange (ETDEWEB)

    Friedman,D.; Wilson, J.; Kovall, R.

    2008-01-01

    The Notch pathway is a conserved cell-to-cell signaling mechanism, in which extracellular signals are transduced into transcriptional outputs through the nuclear effector CSL. CSL is converted from a repressor to an activator through the formation of the CSL-NotchIC-Mastermind ternary complex. The RAM (RBP-J associated molecule) domain of NotchIC avidly interacts with CSL; however, its role in assembly of the CSL-NotchIC-Mastermind ternary complex is not understood. Here we provide a comprehensive thermodynamic, structural, and biochemical analysis of the RAM-CSL interaction for components from both mouse and worm. Our binding data show that RAM and CSL form a high affinity complex in the presence or absence of DNA. Our structural studies reveal a striking distal conformational change in CSL upon RAM binding, which creates a docking site for Mastermind to bind to the complex. Finally, we show that the addition of a RAM peptide in trans facilitates formation of the CSL-NotchIC-Mastermind ternary complex in vitro.

  16. Effect of experimental coronary sinus ligation on myocardial structure and function in the presence or absence of structural heart disease: an insight for the interventional electrophysiologist.

    Science.gov (United States)

    Diab, Osama Ali; Amer, Mohammed Said; Salah El-Din, Rania Ahmed

    2016-12-01

    To study the effect of coronary sinus (CS) occlusion on normal hearts and hearts with structural disease. We included 32 dogs, divided into 4 groups: (1) CS ligation (CSL): subjected to CSL; (2) control group: no intervention; (3) MI-CSL group: subjected to myocardial infarction (MI) induction followed by CSL after 1 week; and (4) MI-control group: subjected to MI induction, then open thoracotomy after 1 week without CSL. Electrocardiography, echocardiography, histopathology, and immunohistochemistry were done before and after CSL. In CSL group, there were no significant electrocardiographic or echocardiographic changes after CSL, although there was interstitial oedema that decreased after 1 week with the appearance of Thebesian vessels and positive staining for vascular endothelial growth factor. In MI-CSL group, there was significant increase in left ventricular (LV) end-systolic diameter (P = 02), decrease in LV fractional shortening (P = 0.0001), and LV ejection fraction (P = 0.002) in comparison with MI-control group, associated with severe myocardial degeneration. Acute CS occlusion could be compensated in normal hearts, but may be detrimental in the presence of structural heart disease. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2016. For permissions please email: journals.permissions@oup.com.

  17. 学前儿童汉语二语习得中的模仿策略研究--以菲律宾Clayton幼儿园教学实践为例%Simulation strategies in the acquisition of CSL of foreign pre-school children:a case study of Clayton Learning Center in the Philippines

    Institute of Scientific and Technical Information of China (English)

    王喜

    2014-01-01

    关于模仿在儿童母语习得中的作用,许多学者已经做了深入研究。但是,模仿在学前儿童汉语二语习得中的具体作用似乎还没有得到详尽的论述。文章以两个年龄组的菲律宾儿童课堂汉语学习语料为基础,对学前儿童在汉语习得过程中采用初级模仿策略和高级模仿策略的具体情况进行分析。文章还阐释了汉语基础及年龄两个因素对儿童选择具体模仿策略的影响,并详尽分析了模仿在学前儿童汉语二语习得中的具体作用机制。%Though the function of simulation in mother-tongue acquisition has received much study, there is still a lot to be studied in the field of pre-school children learning Chinese as a second lan-guage.Based on the authentic dialogues of children in Chinese classes,this paper describes the details of the Philippine pre-school children using simulation strategies.It also discusses the effects of Chi-nese proficiency and age on the choosing of a particular simulation strategy by children,and finally re-veals the specific mechanisms of simulation in pre-school children's acquisition of Chinese as a second language.

  18. Linear plasmid in the genome of Clavibacter michiganensis subsp. sepedonicus.

    Science.gov (United States)

    Brown, Susan E; Knudson, Dennis L; Ishimaru, Carol A

    2002-05-01

    Contour-clamped homogeneous electric field gel analysis of genomic DNA of the plant pathogen Clavibacter michiganensis subsp. sepedonicus revealed the presence of a previously unreported extrachromosomal element. This new element was demonstrated to be a linear plasmid. Of 11 strains evaluated, all contained either a 90-kb (pCSL1) or a 140-kb (pCSL2) linear plasmid.

  19. 76 FR 62850 - Curtis-Straus LLC; Application for Renewal of Recognition

    Science.gov (United States)

    2011-10-11

    ..., OSHA Instruction CPL 01-00-003-CPL 1-0.3) that pressures (i.e., undue influences) do not exist as a... any undue influence. A follow-up response from CSL received by OSHA on January 31, 2008, argued that...). These ``firewalls'' were measures or factors that CSL claimed will mitigate or prevent undue influence...

  20. Community Service-Learning and Cultural-Historical Activity Theory

    Science.gov (United States)

    Taylor, Alison

    2014-01-01

    This paper explores the potential of cultural-historical activity theory (CHAT), to provide new insights into community service-learning (CSL) in higher education. While CSL literature acknowledges the influences of John Dewey and Paolo Freire, discussion of the potential contribution of cultural-historical activity theory, rooted in the work of…

  1. Model checking Quasi Birth Death processes

    NARCIS (Netherlands)

    Remke, A.K.I.

    2004-01-01

    Quasi-Birth Death processes (QBDs) are a special class of infinite state CTMCs that combines a large degree of modeling expressiveness with efficient solution methods. This work adapts the well-known stochastic logic CSL for use on QBDs as CSL and presents model checking algorithms for so-called lev

  2. Strategic Plan: July 2010 to June 2013

    Science.gov (United States)

    California State Library, 2010

    2010-01-01

    On June 15-16, 2010, California State Librarian Stacey A. Aldrich, initiated a strategic planning summit in Sacramento, California. The purpose of the summit was to build the future pathways for the California State Library (CSL)--one of California's oldest cultural institutions. This was accomplished by developing a CSL strategic plan (values,…

  3. Optimization of liquid-liquid extraction of biosurfactants from corn steep liquor.

    Science.gov (United States)

    Vecino, X; Barbosa-Pereira, L; Devesa-Rey, R; Cruz, J M; Moldes, A B

    2015-09-01

    In this work, the optimization of the operational conditions for the chloroform-based extraction of surface-active compounds from corn steep liquor (CSL) was carried out and the nutritional properties of the remnant aqueous phase (CSL-less biosurfactant) was evaluated as microbial fermentation medium. The optimal conditions to obtain biosurfactants from CSL were as follows: chloroform/CSL ratio 2 (v/v), 56 °C at extraction times >30 min. At the optima conditions, 100 % of biosurfactant extract can be obtained from CSL, obtaining 12.0 ± 0.5 g of biosurfactant extract/Kg of CSL. The critical micelle concentration (CMC) of the biosurfactant extract was 399.4 mg L(-1). This value is similar to the CMC of cetrimonium bromide (CTAB), a cationic surfactant used in the formulation of nanoparticles. The extraction of biosurfactant can be also carried out at room temperature although in this case, the extraction yield decreased about 15 %. The extraction of surface-active compounds from agroindustrial streams can suppose important advances for the bio-based surfactants industry. Biosurfactants obtained in this work are not only more eco-friendly than chemical detergents but also can be cost competitive with its chemical counterparts. Furthermore, after the extraction of surface-active compounds, CSL-less biosurfactant was found to be suitable as nutritional supplement for lactic acid bacteria, maintaining its nutritional properties in comparison with regular CSL.

  4. Agro 13 No 3 Ready

    African Journals Online (AJOL)

    hence, the production of bulb in onion is controlled by photoperiod, though temperature .... 68. 54. 64. 50. CSL. SCL. CSL. SCL. 6.40. 6.00. 6.40. 6.20. 5.20. 5.40. 5.20 .... accumulation of carbohydrate due to different concentration of GA & IAA ...

  5. Exquisite specificity of mitogenic lectin from Cephalosporium curvulum to core fucosylated N-glycans.

    Science.gov (United States)

    Inamdar, Shashikala R; Eligar, Sachin M; Ballal, Suhas; Belur, Shivakumar; Kalraiya, Rajiv D; Swamy, Bale M

    2016-02-01

    Lectins are carbohydrate binding proteins that are gaining attention as important tools for the identification of specific glycan markers expressed during different stages of the cancer. We earlier reported the purification of a mitogenic lectin from human pathogenic fungus Cephalosporium curvulum (CSL) that has complex sugar specificity when analysed by hapten inhibition assay. In the present study, we report the fine sugar specificity of CSL as determined by glycan array analysis. The results revealed that CSL has exquisite specificity towards core fucosylated N-glycans. Fucosylated trimannosyl core is the basic structure required for the binding of CSL. The presence of fucose in the side chain further enhances the avidity of CSL towards such glycans. The affinity of CSL is drastically reduced towards the non-core fucosylated glycans, in spite of their side chain fucosylation. CSL showed no binding to the tested O-glycans and monosaccharides. These observations suggest the unique specificity of CSL towards core fucosylated N-glycans, which was further validated by binding of CSL to human colon cancer epithelial and hepatocarcinoma cell lines namely HT29 and HepG2, respectively, that are known to express core fucosylated N-glycans, using AOL and LCA as positive controls. LCA and AOL are fucose specific lectins that are currently being used clinically for the diagnosis of hepatocellular carcinomas. Most of the gastrointestinal markers express core fucosylated N-glycans. The high affinity and exclusive specificity of CSL towards α1-6 linkage of core fucosylated glycans compared to other fucose specific lectins, makes it a promising molecule that needs to be further explored for its application in the diagnosis of gastrointestinal cancer.

  6. Evolutionary Dynamics of the Cellulose Synthase Gene Superfamily in Grasses1[OPEN

    Science.gov (United States)

    Schwerdt, Julian G.; Wright, Frank; Oehme, Daniel; Wagner, John M.; Shirley, Neil J.; Burton, Rachel A.; Schreiber, Miriam; Zimmer, Jochen; Marshall, David F.; Waugh, Robbie; Fincher, Geoffrey B.

    2015-01-01

    Phylogenetic analyses of cellulose synthase (CesA) and cellulose synthase-like (Csl) families from the cellulose synthase gene superfamily were used to reconstruct their evolutionary origins and selection histories. Counterintuitively, genes encoding primary cell wall CesAs have undergone extensive expansion and diversification following an ancestral duplication from a secondary cell wall-associated CesA. Selection pressure across entire CesA and Csl clades appears to be low, but this conceals considerable variation within individual clades. Genes in the CslF clade are of particular interest because some mediate the synthesis of (1,3;1,4)-β-glucan, a polysaccharide characteristic of the evolutionarily successful grasses that is not widely distributed elsewhere in the plant kingdom. The phylogeny suggests that duplication of either CslF6 and/or CslF7 produced the ancestor of a highly conserved cluster of CslF genes that remain located in syntenic regions of all the grass genomes examined. A CslF6-specific insert encoding approximately 55 amino acid residues has subsequently been incorporated into the gene, or possibly lost from other CslFs, and the CslF7 clade has undergone a significant long-term shift in selection pressure. Homology modeling and molecular dynamics of the CslF6 protein were used to define the three-dimensional dispositions of individual amino acids that are subject to strong ongoing selection, together with the position of the conserved 55-amino acid insert that is known to influence the amounts and fine structures of (1,3;1,4)-β-glucans synthesized. These wall polysaccharides are attracting renewed interest because of their central roles as sources of dietary fiber in human health and for the generation of renewable liquid biofuels. PMID:25999407

  7. 论全球金融危机背景下运河城市的旅游发展——以瑞士伯尔尼为例%Urban Tourism Development of Canal Cities against the Backdrop of the Global Financial Crisis-The Case of Bern.Switzerland

    Institute of Scientific and Technical Information of China (English)

    亚历山大·萨帕特

    2009-01-01

    本文主要阐述了两个问题.第一,伯尔尼的旅游业为什么如此成功?第二,伯尔尼的良好态势是否能够持续?特别是在这场全球金融危机的大背景下,伯尔尼将如何应对,促进城市旅游业整体上的可持续发展.

  8. Interview

    Directory of Open Access Journals (Sweden)

    FMR Editors

    2005-05-01

    Full Text Available Walter Kälin, Representative of the UN Secretary- General on the Human Rights of Internally Displaced Persons, co-director of the Brookings-Bern Project on Internal Displacement, and professor of constitutional and international law at Bern University, Switzerland, was interviewed by the FMR Editors in February 2005.

  9. Séminaire de physique corpusculaire | 27 February

    CERN Multimedia

    2013-01-01

      The new Bern cyclotron laboratory for PET radioisotope production and its beam line for multi-disciplinary research, by Dr Saverio Braccini, Albert Einstein Center for Fundamental Physics, University of Bern. Wednesday 27 February 2013 at 11:15 Science III, Auditoire 1S081 30, quai Ernest-Ansermet, 1211 Genève 4 Abstract: The new Bern cyclotron laboratory is based on a 18 MeV proton cyclotron equipped with a specifically conceived 6 m long research beam line, terminated in a separate bunker. This particular configuration is designed for industrial Positron Emission Tomography (PET) radioisotope production as well as for novel detector, radiation biophysics, radiation protection, materials science, radiochemistry and radiopharmacy scientific activities. This project is the result of the successful collaboration among the University Hospital in Bern (Inselspital), the University of Bern, private investors and industrial partners. This new facility is now operational and open to nation...

  10. Six cases showing radial scar/complex sclerosing lesions of the breast detected by breast cancer screening.

    Science.gov (United States)

    Inoue, Shingo; Inoue, Masayuki; Kawasaki, Tomonori; Takahashi, Hifumi; Inoue, Ayako; Maruyama, Takanori; Matsuda, Kei; Kunitomo, Kazuyoshi; Murata, Shinichi; Fujii, Hideki

    2008-01-01

    Recently, the number of radial scars (RS)/complex sclerosing lesions (CSL) of the breast has been increasingly detected by mammography screening. Six RS/CSL cases encountered clinicopathologically in the last 2 years are presented. All patients were pre-menopausal. Three cases were detected by ultrasonography (US) screening, and the others were detected by mammography (MG) screening. Partial mastectomy was carried out for both diagnosis and treatment, since it was difficult to discriminate whether RS/CSL accompanied breast cancer even by US, MG, MRI, aspiration cytology, and spring-loaded core needle biopsy (CNB). RS/CSL was histologically confirmed in all cases, and atypical ductal hyperplasia (ADH) or ductal carcinoma in situ (DCIS) accompanied RS/CSL in each case. At present, the clinical diagnosis of complicated breast cancer is difficult. Therefore, we selected partial mastectomy that resects a wider area than surgical biopsy to adequately diagnose breast cancer and to achieve a resected margin that is free from breast cancer. But it may be that partial resection should be performed in case of older age with larger RS/CSL, since it is over-surgery for RS/CSL without breast cancer. Further studies where complicated breast cancer is certainly identified are necessary.

  11. Effect of corn steep liquor on lettuce root rot (Fusarium oxysporum f.sp. lactucae) in hydroponic cultures.

    Science.gov (United States)

    Chinta, Yufita D; Kano, Kazuki; Widiastuti, Ani; Fukahori, Masaru; Kawasaki, Shizuka; Eguchi, Yumi; Misu, Hideyuki; Odani, Hiromitsu; Zhou, Songying; Narisawa, Kazuhiko; Fujiwara, Kazuki; Shinohara, Makoto; Sato, Tatsuo

    2014-08-01

    Recent reports indicate that organic fertilisers have a suppressive effect on the pathogens of plants grown under hydroponic systems. Furthermore, microorganisms exhibiting antagonistic activity to diseases have been observed in organic hydroponic systems. This study evaluated the effect of corn steep liquor (CSL) on controlling lettuce root rot disease [Fusarium oxysporum f.sp. lactucae (FOL)] in a hydroponic system. The effect of CSL and Otsuka A (a chemical fertiliser) on the inhibition of FOL in terms of mycelial growth inhibition was tested in vivo. Addition of CSL suppressed FOL infection rates. CSL inhibited FOL infection by 26.3-42.5% from 2 days after starting incubation. In comparison, Otsuka A inhibited FOL growth by 5.5-19.4%. In addition, four of 10 bacteria isolated from the nutrient media containing CSL exhibited inhibition zones preventing FOL mycelial growth. We found that CSL suppressed FOL in lettuce via its antifungal and biostimulatory effects. We suggest that activation of beneficial microorganisms present in CSL may be used to decrease lettuce root rot disease and contribute to lettuce root growth. © 2014 Society of Chemical Industry.

  12. Profiling Perceptual Learning Styles of Chinese as a Second Language Learners in University Settings.

    Science.gov (United States)

    Sun, Peijian Paul; Teng, Lin Sophie

    2017-06-21

    This study revisited Reid's (1987) perceptual learning style preference questionnaire (PLSPQ) in an attempt to answer whether the PLSPQ fits in the Chinese-as-a-second-language (CSL) context. If not, what are CSL learners' learning styles drawing on the PLSPQ? The PLSPQ was first re-examined through reliability analysis and confirmatory factor analysis (CFA) with 224 CSL learners. The results showed that Reid's six-factor PLSPQ could not satisfactorily explain the CSL learners' learning styles. Exploratory factor analyses were, therefore, performed to explore the dimensionality of the PLSPQ in the CSL context. A four-factor PLSPQ was successfully constructed including auditory/visual, kinaesthetic/tactile, group, and individual styles. Such a measurement model was cross-validated through CFAs with 118 CSL learners. The study not only lends evidence to the literature that Reid's PLSPQ lacks construct validity, but also provides CSL teachers and learners with insightful and practical guidance concerning learning styles. Implications and limitations of the present study are discussed.

  13. Design and Effectiveness of a Required Pre-Clinical Simulation-based Curriculum for Fundamental Clinical Skills and Procedures

    Directory of Open Access Journals (Sweden)

    Daryl P. Lofaso

    2011-12-01

    Full Text Available For more than 20 years, medical literature has increasingly documented the need for students to learn, practice and demonstrate competence in basic clinical knowledge and skills. In 2001, the Louisiana State University Health Science Centers (LSUHSC School of Medicine – New Orleans replaced its traditional Introduction in to Clinical Medicine (ICM course with the Science and Practice of Medicine (SPM course. The main component within the SPM course is the Clinical Skills Lab (CSL. The CSL teaches 30 plus skills to all pre-clinical medical students (Years 1 and 2. Since 2002, an annual longitudinal evaluation questionnaire was distributed to all medical students targeting the skills taught in the CSL. Students were asked to rate their self- confidence (Dreyfus and Likert-type and estimate the number of times each clinical skill was performed (clinically/non-clinically. Of the 30 plus skills taught, 8 were selected for further evaluation. An analysis was performed on the eight skills selected to determine the effectiveness of the CSL. All students that participated in the CSL reported a significant improvement in self-confidence and in number performed in the clinically/non-clinically setting when compared to students that did not experience the CSL. For example, without CSL training, the percentage of students reported at the end of their second year self-perceived expertise as “novice” ranged from 21.4% (CPR to 84.7% (GU catheterization. Students who completed the two-years CSL, only 7.8% rated their self-perceived expertise at the end of the second year as “novice” and 18.8% for GU catheterization. The CSL design is not to replace real clinical patient experiences. It's to provide early exposure, medial knowledge, professionalism and opportunity to practice skills in a patient free environment.

  14. Natural and anthropogenic influences on depositional architecture of the Ural Delta, Kazakhstan, northern Caspian Sea, during the past 70 years

    Science.gov (United States)

    Scarelli, Frederico M.; Cantelli, Luigi; Barboza, Eduardo G.; Gabbianelli, Giovanni

    2017-05-01

    This paper focuses on the Ural Delta in the northern zone of the Caspian Sea, an area with particular characteristics, where intense influence from anthropogenic and natural factors exists, which acts on the fragile delta system. We built a database to integrate the data from the published sources, bathymetric survey, and recent images in the geographical information system (GIS) environment. The results were linked to the Caspian Sea level (CSL) curve, which had many variations, changing the Ural Delta system's dynamics and in its architecture. In addition, the anthropogenic changes contribute to shaping the actual Ural Delta architecture. Through the link between the results and CSL, we reconstructed an evolution model for the Ural Delta system for the last century and identified three different architectures for the Ural Delta, determined by the energy that acted on the system in the last century and by the anthropogenic changes. This work identifies six different delta phases, which are shaped by CSL changes during the last 70 years and by anthropogenic changes. The delta phases recognized are: i) a Lobate Delta phase, shaped during high CSL before 1935; ii) Natural Elongate Delta 1935-1950 formed during rapid CSL fall; iii) Anthropogenic Elongate Delta 1950-1966, formed during rapid CSL fall and after the Ural-Caspian Sea canal construction, which modified the sedimentary deposition on the delta; iv) Anthropogenic Elongate Delta 1966-1982 shaped during low CSL phase; v) Anthropogenic Elongate Delta 1982-1996 formed during a rapid CSL rise phase; and vi) Anthropogenic Elongate Delta 1996-2009 shaped during high CSL that represent the last phase and actual Ural Delta architecture.

  15. Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.

    Science.gov (United States)

    Nam, Yunsun; Sliz, Piotr; Song, Luyan; Aster, Jon C; Blacklow, Stephen C

    2006-03-10

    Notch receptors transduce essential developmental signals between neighboring cells by forming a complex that leads to transcription of target genes upon activation. We report here the crystal structure of a Notch transcriptional activation complex containing the ankyrin domain of human Notch1 (ANK), the transcription factor CSL on cognate DNA, and a polypeptide from the coactivator Mastermind-like-1 (MAML-1). Together, CSL and ANK create a groove to bind the MAML-1 polypeptide as a kinked, 70 A helix. The composite binding surface likely restricts the recruitment of MAML proteins to promoters on which Notch:CSL complexes have been preassembled, ensuring tight transcriptional control of Notch target genes.

  16. A trace-based model for multiparty contracts

    DEFF Research Database (Denmark)

    Hvitved, Tom; Klaedtke, Felix; Zălinescu, Eugen

    2012-01-01

    assignment is compositional by de¿ning contract conjunction and contract disjunction. Moreover, to specify real-world contracts, we introduce the contract speci¿cation language CSL with an operational semantics. We show that each CSL contract has a counterpart in our trace-based model and from...... the operational semantics we derive a run-time monitor. CSL overcomes limitations of previously proposed formalisms for specifying contracts by supporting: (history sensitive and conditional) commitments, parametrised contract templates, relative and absolute temporal constraints, potentially in¿nite contracts...

  17. Chiral Soliton Lattice and Charged Pion Condensation in Strong Magnetic Fields

    CERN Document Server

    Brauner, Tomas

    2016-01-01

    The Chiral Soliton Lattice (CSL) is a state with a periodic array of topological solitons that spontaneously breaks parity and translational symmetries. Such a state is known to appear in chiral magnets. We show that CSL also appears as a ground state of quantum chromodynamics at nonzero chemical potential in a magnetic field. By analyzing the fluctuations of the CSL, we furthermore demonstrate that in strong but achievable magnetic fields, charged pions undergo Bose-Einstein condensation. Our results, based on a systematic low-energy effective theory, are model-independent and fully analytic.

  18. Are we getting closer to a resolution of the measurement problem?

    CERN Document Server

    Thaheld, F H

    2006-01-01

    In a segment of a recent paper Adler performed an analysis of a CSL reduction mechanism with specific emphasis on where a CSL-type reduction might occur from a biophysical standpoint within the visual system, whether in the retina or in the brain. This revealed that no superposed state can ever be maintained beyond the rod cells of the retina, in agreement with previous non-CSL reduction positions taken by Shimony and the author and, that either approach may lead to a wave function collapse of an objective rather than a subjective nature, providing for a simpler answer to the measurement problem.

  19. Simulations to save time, money, and lives

    Energy Technology Data Exchange (ETDEWEB)

    Sackett, D.E. [Lawrence Livermore National Lab., CA (United States)

    1996-11-01

    The Laboratory`s Conflict Simulation Laboratory (CSL) has been developing computerized programs to simulate combat and other conflicts since 1974. All branches of the military use these systems for training purposes and to prepare for operations as diverse as the 1989 invasion of Panama and peacekeeping in Somalia. The CSL is presently continuing development of the Joint Tactical Simulation (JTS) and recently began work on the Joint Conflict and Tactical Simulation (JCATS) program for the Joint Chiefs of Staff. The Army is still using the CSL`s first model, Janus.

  20. Chiral soliton lattice and charged pion condensation in strong magnetic fields

    Science.gov (United States)

    Brauner, Tomáš; Yamamoto, Naoki

    2017-04-01

    The Chiral Soliton Lattice (CSL) is a state with a periodic array of topological solitons that spontaneously breaks parity and translational symmetries. Such a state is known to appear in chiral magnets. We show that CSL also appears as a ground state of quantum chromodynamics at nonzero chemical potential in a magnetic field. By analyzing the fluctuations of the CSL, we furthermore demonstrate that in strong but achievable magnetic fields, charged pions undergo Bose-Einstein condensation. Our results, based on a systematic low-energy effective theory, are model-independent and fully analytic.

  1. Cricket Club

    CERN Multimedia

    Cricket Club

    2012-01-01

    Bern CC V CERN CC in Bern on Sunday 6th May 2012 The storm clouds gathered over Switzerland this weekend as a CERN XI travelled more in hope than expectation to Bern for our first league game of the season. Despite the gloomy weather forecast the sun shone and Captain Elvin won the toss and put Bern into bat on a damp, soft and tricky wicket. Early success came as D'Mello had the Bern captain caught by D. Ahmed in his second over. This was to prove the only success in the first 20 overs as BERN made light of the pitch and the CERN attack to go into the drinks break on 108-1. CERN came storming out after the break with Elvin making the breakthrough to dismiss the Bern number 2 for 74. D'Mello then came back into the attack and ended up with 4-34 as CERN held their catches and fielded well. Chauduri was in fine form and stormed in to take 3-27. Elvin was tight and economical until he went for 23 in his final over but D. Ahmed mopped up the tail with 2-16 in a fine 4 over spell. CERN...

  2. Radiation-induced segregation and corrosion behavior on Σ3 coincidence site lattice and random grain boundaries in proton-irradiated type-316L austenitic stainless steel

    Energy Technology Data Exchange (ETDEWEB)

    Sakaguchi, N., E-mail: sakaguchi@eng.hokudai.ac.jp [Center for Advanced Research of Energy and Materials, Faculty of Engineering, Hokkaido University, Sapporo 060-8628, Hokkaido (Japan); Endo, M.; Watanabe, S. [Center for Advanced Research of Energy and Materials, Faculty of Engineering, Hokkaido University, Sapporo 060-8628, Hokkaido (Japan); Kinoshita, H. [Fukushima National College of Technology, Iwaki 970-8034, Fukushima (Japan); Yamashita, S. [Fuels and Materials Department, O-arai Research and Development Center, Japan Atomic Energy Agency, Ibaraki 311-1393 (Japan); Kokawa, H. [Graduate School of Engineering, Tohoku University, Sendai 980-8579 (Japan)

    2013-03-15

    The behavior of radiation-induced segregation (RIS) and intergranular corrosion at random grain boundaries and Σ3 coincidence site lattice (CSL) boundaries in proton-irradiated 316L stainless steel was examined. The frequency of the CSL boundaries was enhanced up to 86.6% by grain boundary engineering treatment prior to irradiation. Significant nickel enrichment and chromium depletion were induced at the random grain boundary owing to the RIS. At faceted Σ3 CSL boundaries, chromium depletion occurred at the asymmetrical boundary facet plane whereas no RIS was observed at the coherent twin boundary. After the electrochemical etching test, an intergranular corrosion groove was found along the random grain boundaries because of the low chromium concentration (∼12%) at the boundaries. At the faceted Σ3 CSL boundaries, the discontinuous groove along the asymmetric facet plane was completely disrupted by the non-corrosive coherent twin boundary.

  3. Atmospheric forcing on the seasonal variability of sea level at Cochin, southwest coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Srinivas, K.; DineshKumar, P.K.

    indicated strong interannual variability whereas relative density showed strong seasonal variability. The climatological seasonal cycles of CSL at eight other tide gauge stations along the west coast of the Indian subcontinent are also examined, to assess...

  4. Possible SU(3) chiral spin liquid on the kagome lattice

    Science.gov (United States)

    Wu, Ying-Hai; Tu, Hong-Hao

    2016-11-01

    We propose an SU(3) symmetric Hamiltonian with short-range interactions on the kagome lattice and show that it hosts an Abelian chiral spin liquid (CSL) state. We provide numerical evidence based on exact diagonalization to show that this CSL state is stabilized in an extended region of the parameter space and can be viewed as a lattice version of the Halperin 221 fractional quantum Hall state of two-component bosons. We also construct a parton wave function for this CSL state and demonstrate that its variational energies are in good agreement with exact diagonalization results. The parton description further supports that the CSL is characterized by a chiral edge conformal field theory of the SU (3) 1 Wess-Zumino-Witten type.

  5. Primary User Localization Algorithm Based on Compressive Sensing in Cognitive Radio Networks

    Directory of Open Access Journals (Sweden)

    Fang Ye

    2016-04-01

    Full Text Available In order to locate source signal more accurately in authorized frequency bands, a novel primary user localization algorithm based on compressive sensing (PU-CSL in cognitive radio networks (CRNs is proposed in this paper. In comparison to existing centroid locating algorithms, PU-CSL shows higher locating accuracy for integrally exploring correlation between source signal and secondary users (SUs. Energy detection is first adopted for collecting the energy fingerprint of source signal at each SU, then degree of correlation between source signal and SUs is reconstructed based on compressive sensing (CS, which determines weights of centroid coordinates. A weighted centroid scheme is finally utilized to estimate source position. Simulation results show that PU-CSL has smaller maximum error of positioning and root-mean-square error. Moreover, the proposed PU-CSL algorithm possess excellent location accuracy and strong anti-noise performance.

  6. CSLs of the root lattice A{sub 4}

    Energy Technology Data Exchange (ETDEWEB)

    Heuer, M [Department of Mathematics and Statistics, Open University, Milton Keynes (United Kingdom); Zeiner, P, E-mail: m.heuer@open.ac.u, E-mail: pzeiner@math.uni-bielefeld.d [Fakultaet fuer Mathematik, Universitaet Bielefeld (Germany)

    2010-04-01

    Recently, the group of coincidence isometries of the root lattice A{sub 4} has been determined providing a classification of these isometries with respect to their coincidence indices. A more difficult task is the classification of all CSLs, since different coincidence isometries may generate the same CSL. In contrast to the typical examples in dimensions d {<=} 3, where coincidence isometries generating the same CSL can only differ by a symmetry operation, the situation is more involved in 4 dimensions. Here, we find coincidence isometries that are not related by a symmetry operation but nevertheless give rise to the same CSL. We indicate how the classification of CSLs can be obtained by making use of the icosian ring and provide explicit criteria for two isometries to generate the same CSL. Moreover, we determine the number of CSLs of a given index and encapsulate the result in a Dirichlet series generating function.

  7. Chitosan based atorvastatin nanocrystals: effect of cationic charge on particle size, formulation stability, and in-vivo efficacy

    National Research Council Canada - National Science Library

    Kurakula, Mallesh; El-Helw, A M; Sobahi, Tariq R; Abdelaal, Magdy Y

    2015-01-01

    .... The influence of cationic charge densities of chitosan (low CS(L), medium CS(M), high CS(H) molecular weights) and Labrasol(®) in solubility enhancement and modifying the release was investigated, using atorvastatin...

  8. Arabidopsis CDS blastp result: AK242890 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK242890 J090079L19 At3g03050.1 68416.m00301 cellulose synthase family protein (CslD3) similar to cellulose... synthase catalytic subunit gi:2827143 from [Arabidopsis thaliana], cellulose syntha

  9. Arabidopsis CDS blastp result: AK242585 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK242585 J090010M20 At3g03050.1 68416.m00301 cellulose synthase family protein (CslD3) similar to cellulose... synthase catalytic subunit gi:2827143 from [Arabidopsis thaliana], cellulose syntha

  10. Arabidopsis CDS blastp result: AK110467 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK110467 002-166-G08 At3g03050.1 cellulose synthase family protein (CslD3) similar to cellulose... synthase catalytic subunit gi:2827143 from [Arabidopsis thaliana], cellulose synthase-7 (gi:962

  11. Research

    African Journals Online (AJOL)

    2013-11-02

    Nov 2, 2013 ... alternate between the roles of teachers and learners.[1] Peer ... learning habits, acquire new advanced perceptions towards the subject matter, and ... feedback, demonstrate the five steps of skills teaching in the CSL, set the.

  12. Optimization of a corn steep medium for production of ethanol from synthesis gas fermentation by Clostridium ragsdalei.

    Science.gov (United States)

    Saxena, Jyotisna; Tanner, Ralph S

    2012-04-01

    Fermentation of biomass derived synthesis gas to ethanol is a sustainable approach that can provide more usable energy and environmental benefits than food-based biofuels. The effects of various medium components on ethanol production by Clostridium ragsdalei utilizing syngas components (CO:CO(2)) were investigated, and corn steep liquor (CSL) was used as an inexpensive nutrient source for ethanol production by C. ragsdalei. Elimination of Mg(2+), NH(4) (+) and PO(4) (3-) decreased ethanol production from 38 to 3.7, 23 and 5.93 mM, respectively. Eliminating Na(+), Ca(2+), and K(+) or increasing Ca(2+), Mg(2+), K(+), NH(4) (+) and PO(4) (3-) concentrations had no effect on ethanol production. However, increased Na(+) concentration (171 mM) inhibited growth and ethanol production. Yeast extract (0.5 g l(-1)) and trace metals were necessary for growth of C. ragsdalei. CSL alone did not support growth and ethanol production. Nutrients limiting in CSL were trace metals, NH(4) (+) and reducing agent (Cys: cysteine sulfide). Supplementation of trace metals, NH(4) (+) and CyS to CSL (20 g l(-1), wet weight basis) yielded better growth and similar ethanol production as compared to control medium. Using 10 g l(-1), the nutritional limitation led to reduced ethanol production. Higher concentrations of CSL (50 and 100 g l(-1)) were inhibitory for cell growth and ethanol production. The CSL could replace yeast extract, vitamins and minerals (excluding NH(4) (+)). The optimized CSL medium produced 120 and 50 mM of ethanol and acetate, respectively. The CSL could provide as an inexpensive source of most of the nutrients required for the syngas fermentation, and thus could improve the economics of ethanol production from biomass derived synthesis gas by C. ragsdalei.

  13. Gene deletion strategy to examine the involvement of the two chondroitin lyases in Flavobacterium columnare virulence.

    Science.gov (United States)

    Li, Nan; Qin, Ting; Zhang, Xiao Lin; Huang, Bei; Liu, Zhi Xin; Xie, Hai Xia; Zhang, Jin; McBride, Mark J; Nie, Pin

    2015-11-01

    Flavobacterium columnare is an important bacterial pathogen of freshwater fish that causes high mortality of infected fish and heavy economic losses in aquaculture. The pathogenesis of this bacterium is poorly understood, in part due to the lack of efficient methods for genetic manipulation. In this study, a gene deletion strategy was developed and used to determine the relationship between the production of chondroitin lyases and virulence. The F. johnsoniae ompA promoter (PompA) was fused to sacB to construct a counterselectable marker for F. columnare. F. columnare carrying PompA-sacB failed to grow on media containing 10% sucrose. A suicide vector carrying PompA-sacB was constructed, and a gene deletion strategy was developed. Using this approach, the chondroitin lyase-encoding genes, cslA and cslB, were deleted. The ΔcslA and ΔcslB mutants were both partially deficient in digestion of chondroitin sulfate A, whereas a double mutant (ΔcslA ΔcslB) was completely deficient in chondroitin lyase activity. Cells of F. columnare wild-type strain G4 and of the chondroitin lyase-deficient ΔcslA ΔcslB mutant exhibited similar levels of virulence toward grass carp in single-strain infections. Coinfections, however, revealed a competitive advantage for the wild type over the chondroitin lyase mutant. The results indicate that chondroitin lyases are not essential virulence factors of F. columnare but may contribute to the ability of the pathogen to compete and cause disease in natural infections. The gene deletion method developed in this study may be employed to investigate the virulence factors of this bacterium and may have wide application in many other members of the phylum Bacteroidetes.

  14. Predicting Trophic Interactions and Habitat Utilization in the California Current Ecosystem

    Science.gov (United States)

    2013-09-30

    boundary conditions and surface atmospheric forcing for ROMS are derived respectively from the Simple Ocean Data Assimilation ( SODA ) reanalysis and from...the datasets for Common Ocean-Ice Reference Experiments (CORE2). SODA and CORE2 both encompass the period 1959-2009, which allows us to run a...and CSL attributes determined by environmental conditions (e.g., growth, behavior) are updated at the same frequency. For male CSL, hourly consumption

  15. Microstructural and textural changes in a severely cold rolled boron-added interstitial-free steel

    Energy Technology Data Exchange (ETDEWEB)

    Saha, Rajib [Indian Institute of Technology, Kanpur 208 016 (India); R and D Division, Tata Steel, Jamshedpur (India)], E-mail: rajib.saha@tatasteel.com; Ray, R.K. [Indian Institute of Technology, Kanpur 208 016 (India); R and D Division, Tata Steel, Jamshedpur (India)

    2007-11-15

    The severe cold rolling of a single sheet of boron-added Ti + Nb IF steel at room temperature can produce nano- to ultrafine-sized grains. The number fraction of high-angle grain boundaries increases up to 98% cold rolling and then shows a perceptible decrease after further cold rolling. The coincidence site lattice (CSL) boundary fraction increases continuously with deformation. The most prominent among these CSL boundaries are the {sigma}3, {sigma}11 and {sigma}13b types.

  16. A SPEECH RECOGNITION METHOD USING COMPETITIVE AND SELECTIVE LEARNING NEURAL NETWORKS

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    On the basis of asymptotic theory of Gersho, the isodistortion principle of vector clustering was discussed and a kind of competitive and selective learning method (CSL) which may avoid local optimization and have excellent result in application to clusters of HMM model was also proposed. In combining the parallel, self-organizational hierarchical neural networks (PSHNN) to reclassify the scores of every form output by HMM, the CSL speech recognition rate is obviously elevated.

  17. The Impact of Female Education on Teenage Fertility: Evidence from Turkey

    OpenAIRE

    Gunes, Pinar

    2015-01-01

    This paper explores the causal relationship between female education and teenage fertility by exploiting a change in the compulsory schooling law (CSL) in Turkey. Using variation in the exposure to the CSL across cohorts and variation across provinces by the intensity of additional classrooms constructed in the birth provinces as an instrumental variable, the results indicate that primary school completion reduces teenage fertility by 0.37 births and the incidence of teenage childbearing by a...

  18. Ultrasound Assisted Synthesis of Hydroxylated Soybean Lecithin from Crude Soybean Lecithin as an Emulsifier.

    Science.gov (United States)

    Chiplunkar, Pranali P; Pratap, Amit P

    2017-09-15

    Soybean lecithin is a by-product obtained during degumming step of crude soybean oil refining. Crude soybean lecithin (CSL) contains major amount of phospholipids (PLs) along with minor amount of acylglycerols, bioactive components, etc. Due to presence of PLs, CSL can be used as an emulsifier. Crude soybean lecithin (CSL) was utilized to synthesize hydroxylated soybean lecithin (HSL) by hydroxylation using hydrogen peroxide and catalytic amount of lactic acid to enhance the hydrophilicity and emulsifying properties of CSL. To reduce the reaction time and to increase rate of reaction, HSL was synthesized under ultrasound irradiation. The effect of different operating parameters such as lactic acid, hydrogen peroxide, temperature, ultrasonic power and duty cycle in synthesis of HSL were studied and optimized. The surface tension (SFT), interfacial tension (IFT) and the critical micelle concentration (CMC) of the HSL (26.11 mN/m, 2.67 mN/m, 112 mg/L) were compared to CSL (37.53 mN/m, 6.22 mN/m, 291 mg/L) respectively. The HSL has better emulsion stability and low foaming characteristics as compared to CSL. Therefore, the product as an effective emulsifier can be used in food, pharmacy, lubricant, cosmetics, etc.

  19. Long-term Caspian Sea level change

    Science.gov (United States)

    Chen, J. L.; Pekker, T.; Wilson, C. R.; Tapley, B. D.; Kostianoy, A. G.; Cretaux, J.-F.; Safarov, E. S.

    2017-07-01

    Caspian Sea level (CSL) has undergone substantial fluctuations during the past several hundred years. The causes over the entire historical period are uncertain, but we investigate here large changes seen in the past several decades. We use climate model-predicted precipitation (P), evaporation (E), and observed river runoff (R) to reconstruct long-term CSL changes for 1979-2015 and show that PER (P-E + R) flux predictions agree very well with observed CSL changes. The observed rapid CSL increase (about 12.74 cm/yr) and significant drop ( -6.72 cm/yr) during the periods 1979-1995 and 1996-2015 are well accounted for by integrated PER flux predictions of +12.38 and -6.79 cm/yr, respectively. We show that increased evaporation rates over the Caspian Sea play a dominant role in reversing the increasing trend in CSL during the past 37 years. The current long-term decline in CSL is expected to continue into the foreseeable future, under global warming scenarios.

  20. Molecular epidemiology of Cryptosporidium spp. and Giardia spp. in mussels (Mytilus californianus) and California sea lions (Zalophus californianus) from Central California.

    Science.gov (United States)

    Adell, A D; Smith, W A; Shapiro, K; Melli, A; Conrad, P A

    2014-12-01

    Cryptosporidium and Giardia are of public health importance, with recognized transmission through recreational waters. Therefore, both can contaminate marine waters and shellfish, with potential to infect marine mammals in nearshore ecosystems. A 2-year study was conducted to evaluate the presence of Cryptosporidium and Giardia in mussels located at two distinct coastal areas in California, namely, (i) land runoff plume sites and (ii) locations near sea lion haul-out sites, as well as in feces of California sea lions (CSL) (Zalophus californianus) by the use of direct fluorescent antibody (DFA) detection methods and PCR with sequence analysis. In this study, 961 individual mussel hemolymph samples, 54 aliquots of pooled mussel tissue, and 303 CSL fecal samples were screened. Giardia duodenalis assemblages B and D were detected in hemolymph from mussels collected near two land runoff plume sites (Santa Rosa Creek and Carmel River), and assemblages C and D were detected in hemolymph from mussels collected near a sea lion haul-out site (White Rock). These results suggest that mussels are being contaminated by protozoa carried in terrestrial runoff and/or shed in the feces of CSL. Furthermore, low numbers of oocysts and cysts morphologically similar to Cryptosporidium and Giardia, respectively, were detected in CSL fecal samples, suggesting that CSL could be a source and a host of protozoan parasites in coastal environments. The results of this study showed that Cryptosporidium and Giardia spp. from the feces of terrestrial animals and CSL can contaminate mussels and coastal environments.

  1. Study of the surfactant properties of aqueous stream from the corn milling industry.

    Science.gov (United States)

    Vecino, X; Barbosa-Pereira, L; Devesa-Rey, R; Cruz, J M; Moldes, A B

    2014-06-18

    Corn steep liquor (CSL) is a liquid byproduct generated by the corn wet-milling industry. This agroindustrial residue is obtained when corn is digested with warm water and SO2 in the presence of different spontaneously growing microorganisms. The microbial population of CSL includes lactic acid bacteria, which are widely known to produce biosurfactants. However, there is no information available about the possible existence of surface-active compounds in CSL. In this work the surface tension activity of CSL was evaluated and the biosurfactant contained in this residue was extracted with different organic solvents and characterized. The biosurfactant obtained from CSL was analyzed by Fourier transform infrared spectroscopy, and the composition in fatty acid was analyzed by gas chromatography-mass spectrometry. The hydrophobic chain of the biosurfactant contained in CSL comprised 50-55.2% linolelaidic acid, 15.7-22.2% oleic and/or elaidic acid, 5.9-14.6% stearic acid, and 14.9-19.6% palmitic acid.

  2. Plaadid / Valner Valme

    Index Scriptorium Estoniae

    Valme, Valner, 1970-

    2003-01-01

    Heliplaatide "Higha Collection 3", "My Big Fat Greek Wedding", Apocalyptica "Reflections", The Raveonettes "Whip It On", Kaunimate Vennaskond "Kaunimad astad su elus", Led Zeppelin "Early Days& Latter Days", "The Heart And SAoul Of Bert Berns", Groove Armanda "Love Box" tutvustus

  3. Plaadid / Valner Valme

    Index Scriptorium Estoniae

    Valme, Valner, 1970-

    2003-01-01

    Heliplaatide "Higha Collection 3", "My Big Fat Greek Wedding", Apocalyptica "Reflections", The Raveonettes "Whip It On", Kaunimate Vennaskond "Kaunimad astad su elus", Led Zeppelin "Early Days& Latter Days", "The Heart And SAoul Of Bert Berns", Groove Armanda "Love Box" tutvustus

  4. [Karin Hallas. Das Tallinner Mietshaus. Vom Historismus bis zum Jugendstil] / Paul Kaegbein

    Index Scriptorium Estoniae

    Kaegbein, Paul

    2006-01-01

    Arvustus: Karin Hallas. Das Tallinner Mietshaus. Vom Historismus bis zum Jugendstil. In: Architektur und bildende Kunst im Baltikum um 1900. Frankfurt am Main, Berlin, Bern, Bruxelles, New York, Wien: Lang 1999. S. 173-192.

  5. Nova libro pri interlingvistiko

    Index Scriptorium Estoniae

    2006-01-01

    Rets rmt.: Blanke, Detlev. Interlinguistische Beiträge : zum Wesen und zur Plansprachen / herausgegeben von Sabine Fiedler. Frankfurt/Main, Berlin ; Bern ; Bruxelles ; New York ; Oxford ; Wien : Europäischer Verlag der Wissenschaften Peter Lang

  6. Nova libro pri interlingvistiko

    Index Scriptorium Estoniae

    2006-01-01

    Rets rmt.: Blanke, Detlev. Interlinguistische Beiträge : zum Wesen und zur Plansprachen / herausgegeben von Sabine Fiedler. Frankfurt/Main, Berlin ; Bern ; Bruxelles ; New York ; Oxford ; Wien : Europäischer Verlag der Wissenschaften Peter Lang

  7. Canadian Copyright: History, Change, and Potential

    National Research Council Canada - National Science Library

    Sara Bannerman

    2011-01-01

      The foundation of international copyright since 1886 has been the Berne Convention-the world's first broadly multilateral copyright treaty, which still acts as the cornerstone of international copyright today...

  8. Early Recognition of Chronic Traumatic Encephalopathy through FDDNP PET Imaging

    Science.gov (United States)

    2016-10-01

    student, Bern who has worked on assessing the relationship FDDNP imaging results and neuropsychological measures. Preliminary results noted above have...17), Neuropsychological Society (New 2/17). Over the next reporting period, emphasis will be placed on completing enrollment (hopefully by...BernG. Uptake, Neurocognition, and Number of Boxers and MMA Neuropsychology Society, New No products resulted from this study over the last year

  9. The in vitro neuromuscular activity of Indo-Pacific sea-snake venoms: efficacy of two commercially available antivenoms.

    Science.gov (United States)

    Chetty, Navinisha; Du, Amanda; Hodgson, Wayne C; Winkel, Ken; Fry, Bryan G

    2004-08-01

    We examined the neurotoxicity of the following sea snake venoms: Enhydrina schistosa (geographical variants from Weipa and Malaysia), Lapemis curtus (Weipa and Malaysia), Laticauda colubrina, Aipysurus laevis, Aipysurus fuscus and Aipysurus foliosquamatus. Venom from a terrestrial snake, Notechis scutatus (tiger snake), was used as a reference. All venoms (1 and 3 microg/ml) abolished indirect twitches of the chick biventer cervicis muscle and significantly inhibited responses to ACh (1 mM) and CCh (20 microM), but not KCl (40 mM), indicating the presence of post-synaptic toxins. Prior administration (10 min) of CSL sea snake antivenom (1 unit/ml) attenuated the twitch blockade produced by N. scutatus venom and all sea snake venoms (1 microg/ml). Prior administration (10 min) of CSL tiger snake antivenom (1 unit/ml) attenuated the twitch blockade of all venoms except those produced by E. schistosa (Malaysia and Weipa) and A. foliosquamatus. Administration of CSL sea snake antivenom (1 unit/ml) at t90 (i.e. time at which 90% inhibition of initial twitch height occurred) reversed the inhibition of twitches (20-50%) produced by the sea snake venoms (1 microg/ml) but not by N. scutatus venom (1 microg/ml). CSL tiger snake antivenom (1 unit/ml) administered at t90 produced only minor reversal (i.e. 15-25%) of the twitch blockade caused by L. curtus (Weipa), A. foliosquamatus, L. colubrina and A. laevis venoms (1 microg/ml). Differences in the rate of reversal of the neurotoxicity produced by the two geographical variants of E. schistosa venom, after addition of CSL sea snake antivenom, indicate possible differences in venom components. This study shows that sea snake venoms contain potent post-synaptic activity that, despite the significant genetic distances between the lineages, can be neutralised with CSL sea snake antivenom. However, the effects of CSL tiger snake antivenom are more variable.

  10. Complex sclerosing lesions and radial sclerosing lesions on core needle biopsy: Low risk of carcinoma on excision in cases with clinical and imaging concordance.

    Science.gov (United States)

    Nakhlis, Faina; Lester, Susan; Denison, Christine; Wong, Stephanie M; Mongiu, Anne; Golshan, Mehra

    2017-07-07

    Complex or radial sclerosing lesions (CSL/RSL) are uncommon diagnoses on core needle biopsy with a reported upgrade rate ranging between 0% and 23%. As a result, their management remains controversial. In this study, we sought to determine the rate of malignancy on excision for patients with pure CSL/RSL on core biopsy, and to evaluate future breast cancer risk when CSL/RSL is managed without excision. We retrospectively reviewed 118 cases of CSL/RSL diagnosed on image-guided breast biopsies between 2005 and 2014 at our institution. Of 98 analyzed patients, 34 (35%) underwent excision and 64 (65%) were observed. Demographic and clinical variables between excision and observation groups were compared. In excised specimens, factors associated with upgrade to malignancy were evaluated. The median age at diagnosis was 49 years (range, 27-88 years). In the excision group, 3/34 cases were associated with malignancy, an overall upgrade rate of 9%. All malignant cases had core needle biopsies interpreted as discordant and were BIRADS 4B or more on imaging. In the observation group, at a median follow-up of 2.2 years, 3/64 (5%) patients developed ipsilateral cancers, all of which were distant from the index CSL/RSL. In our series, we report a 9% malignancy rate on excision of BIRADS >4C lesions characterized as CSL/RSL on core biopsy. In patients with concordant biopsies and BIRADS 4A or lower lesions who underwent observation, we found a low rate of subsequent ipsilateral cancers. Further studies are needed to confirm that for CSL/RSL in concordant core biopsies and BIRADS 4A or lower, nonpalpable lesions, observation may be a reasonable alternative to excision. © 2017 Wiley Periodicals, Inc.

  11. Current spreading in GaN-based light-emitting diodes

    Science.gov (United States)

    Li, Qiang; Li, Yufeng; Zhang, Minyan; Ding, Wen; Yun, Feng

    2016-11-01

    We have investigated the factors affecting the current spreading length (CSL) in GaN-based light-emitting diodes (LEDs) by deriving theoretical expressions and performing simulations with APSYS. For mesa-structure LEDs, the effects of both indium tin oxide (ITO) and n-GaN are taken into account for the first time, and a new Q factor is introduced to explain the effects of different current flow paths on the CSL. The calculations and simulations show that the CSL can be enhanced by increasing the thickness of the ITO layer and resistivity of the n-GaN layer, or by reducing the resistivity of the ITO layer and thickness of the n-GaN layer. The results provide theoretical support for calculating the CSL clearly and directly. For vertical-structure LEDs, the effects of resistivity and thickness of the CSL on the internal quantum efficiency (IQE) have been analyzed. The theoretical expression relating current density and the parameters (resistivity and thickness) of the CSL is obtained, and the results are then verified by simulation. The IQE under different current injection conditions is discussed. The effects of CSL resistivity play a key role at high current injection, and there is an optimal thickness for the largest IQE only at a low current injection. Project supported by the National High Technology Research and Development Program of China (Grant No. 2014AA032608), the National Natural Science Foundation of China (Grant No. 61404101), and the China Postdoctoral Science Foundation (Grant No. 2014M562415).

  12. Chitosan based atorvastatin nanocrystals: effect of cationic charge on particle size, formulation stability, and in-vivo efficacy

    Directory of Open Access Journals (Sweden)

    Kurakula M

    2015-01-01

    Full Text Available Mallesh Kurakula,1 AM El-Helw,2 Tariq R Sobahi,1 Magdy Y Abdelaal11Polymer Research Lab, Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia; 2Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi ArabiaAbstract: Cationic charged chitosan as stabilizer was evaluated in preparation of nanocrystals using probe sonication method. The influence of cationic charge densities of chitosan (low CSL, medium CSM, high CSH molecular weights and Labrasol® in solubility enhancement and modifying the release was investigated, using atorvastatin (ATR as poorly soluble model drug. Compared to CSM and CSH; low cationic charge of CSL acted as both electrostatic and steric stabilizer by significant size reduction to 394 nm with charge of 21.5 meV. Solubility of ATR-CSL increased to 60-fold relative to pure ATR and ATR-L. Nanocrystals were characterized for physiochemical properties. Scanning electron microscopy revealed scaffold-like structures with high surface area. X-ray powder diffractometry and differential scanning calorimetry revealed crystalline to slight amorphous state changes after cationic charge size reduction. Fourier transform-infrared spectra indicated no potent drug-excipient interactions. The enhanced dissolution profile of ATR-CSL indicates that sustained release was achieved compared with ATR-L and Lipitor®. Anti-hyperlipidemic performance was pH dependent where ATR-CSL exhibited 2.5-fold higher efficacy at pH 5 compared to pH 6 and Lipitor®. Stability studies indicated marked changes in size and charge for ATR-L compared to ATR-CSL exemplifying importance of the stabilizer. Therefore, nanocrystals developed with CSL as a stabilizer is a promising choice to enhance dissolution, stability, and in-vivo efficacy of major Biopharmaceutical Classification System II/IV drugs.Keywords: atorvastatin, anti-hyperlipidemia, chitosan, cationic charge, stability, nanocrystals

  13. Role of viral RNA and lipid in the adverse events associated with the 2010 Southern Hemisphere trivalent influenza vaccine.

    Science.gov (United States)

    Rockman, Steve; Becher, Dorit; Dyson, Allison; Koernig, Sandra; Morelli, Adriana Baz; Barnden, Megan; Camuglia, Sarina; Soupourmas, Peter; Pearse, Martin; Maraskovsky, Eugene

    2014-06-24

    In Australia, during the 2010 Southern Hemisphere (SH) influenza season, there was an unexpected increase in post-marketing adverse event reports of febrile seizures (FS) in children under 5 years of age shortly after vaccination with the CSL 2010 SH trivalent influenza vaccine (CSL 2010 SH TIV) compared to previous CSL TIVs and other licensed 2010 SH TIVs. In an accompanying study, we described the contribution to these adverse events of the 2010 SH influenza strains as expressed in the CSL 2010 SH TIV using in vitro cytokine/chemokine secretion from whole blood cells and induction of NF-κB activation in HEK293 reporter cells. The aim of the present study was to identify the root cause components that elicited the elevated cytokine/chemokine and NF-κB signature. Our studies demonstrated that the pyrogenic signal was associated with a heat-labile, viral-derived component(s) in the CSL 2010 SH TIV. Further, it was found that viral lipid-mediated delivery of short, fragmented viral RNA was the key trigger for the increased cytokine/chemokine secretion and NF-κB activation. It is likely that the FS reported in children viral components of the new influenza strains (particularly B/Brisbane/60/2008 and to a lesser extent H1N1 A/California/07/2009). These combined to heighten immune activation of innate immune cells, which in a small proportion of children <5 years of age is associated with the occurrence of FS. The data also demonstrates that CSL TIVs formulated with increased levels of splitting agent (TDOC) for the B/Brisbane/60/2008 strain can attenuate the pro-inflammatory signals in vitro, identifying a potential path forward for generating a CSL TIV indicated for use in children <5 years.

  14. Effects of feeding different levels of corn steep liquor on the performance of fattening lambs.

    Science.gov (United States)

    Azizi-Shotorkhoft, A; Sharifi, A; Mirmohammadi, D; Baluch-Gharaei, H; Rezaei, J

    2016-02-01

    This study was conducted to assess the effect of feeding corn steep liquor (CSL) on in vivo digestibility, ruminal pH, ammonia and hydrolytic enzyme activities, blood metabolites, feed intake (FI) and growth performance in fattening lambs. The CSL is a by-product of wet milling process of maize starch industry. The crude protein (CP), rumen-degradable protein (RDP), lactic acid and metabolisable energy contents of this by-product were 420, 324, 200 g/kg dry matter (DM) and 12.6 MJ/kg DM respectively. Twenty-seven male Moghani lambs were assigned randomly into three groups of nine lambs each in a completely randomised design. Three iso-energetic and iso-nitrogenous diets containing different levels (0, 50 or 100 g/kg dry matter) of CSL were offered ad libitum three times a day. Forage to concentrate ratio of the diets was 30:70. With inclusion of CSL in diet, the contents of canola meal, fish meal, wheat bran, corn grain and sugar beet pulp were decreased. The contents of DM, ash-free neutral detergent fibre (NDFom), ether extract, starch, Ca and S were numerically lower, but soluble protein, RDP and non-fibre carbohydrates were greater in the diets containing CSL in comparison with the control diet. The lambs fed with the diets containing CSL had lower [linear (L), p acid detergent fibre, and average daily gain. However, the feed conversion ratio was similar among the experimental animals. Overall, feeding CSL up to 100 g/kg diet DM in lamb resulted in reductions of rumen fibrolytic microbial enzyme activities, in vivo digestibility, FI and growth performance, but rumen proteases activity increased. Journal of Animal Physiology and Animal Nutrition © 2015 Blackwell Verlag GmbH.

  15. (-)-Stepholidine v s 12-chloroscoulerine enantiomers on firing activity of substantia nigral dopamine neurons%左旋千金藤立定和12-氯斯阔任旋光异构体对黑质多巴胺神经元放电活动的比较

    Institute of Scientific and Technical Information of China (English)

    张雪翔; 金国章

    1996-01-01

    AIM: To compare the potencies between (-)-stepholidine ((-)-SPD) and 12-chloroscoulerine (CSL) enantiomers on firing of substantia nigra (SN) dopamine (DA) neurons. METHODS:Extracellular single unit recordings in paralyzed rats. RESULTS: In rats, (-)-SPD, (-)-,( ± )-, and (+)-CSL attenuated iv apomorphine of DA cell, and their ED50 values were 15.1(11.9-19.4), 7.8 (7.0-8.7), 12.6 (2.0respectively. Thus, (-)-CSL was 1 time morepotent than (-)-SPD and 371 times more potentthan (+)-CSL on D2 receptors. In reserpinizedrats, ( - )-SPD, ( - )-, ( ± )-, and (+)-CSLSKF-38393, with ED50 values of 0.53 (0.51-0.55), 0.51 (0.43-0. 60), 1.2 (0.7-2.0),The potency of (-)-CSL was similar to that of(-)-SPD on D1 receptors and 11 times higherthan that of (+)-CSL. CONCLUSION: CSLenantiomers are D1/D2 mixed antagonists as(-)-SPD. (-)-CSL is the most, while(+)-CSL is the least, potent one among them.%目的:比较左旋千金藤立定((一)-stepholidine,(一)-SPD)和12-氯斯阔任(12-chloroscoulerine,CSL)对黑质(substantia nigra,SN)多巴胺(DA)神经元放电的影响.方法:麻痹大鼠上的胞外单单位记录.结果:在大鼠,(一)-SPD,(一)-,(±)-和(+)-CSL减弱iv 10μg·kg-1阿朴吗啡引起的放电抑制.ED50值分别为15.1(11.9-19.4),7.8(7.0-8.7),12.6(2.0-17.9)μg·kg-1和2.9(2.6-3.3)mg·kg-1.(一)-CSL比(一)-SPD强1倍,比(+)-CSL强371倍.在利血平化大鼠,(一)-SPD,(一)-,(±)-,和(+)-CSL减弱4 mg·kg-1 SKF-38393引起的放电抑制.ED50值为0.53(0.51-0.55),0.51(0.43-0.60),1.2(0.7-2.0)和5.9(4.9-7.1)mg·kg-1.(一)-CSL的强度与(一)-SPD相似,比(+)-CSL强11倍.结论:(一)-SPD和CSL是D1/D2混合性阻滞剂.(一)-CSL最强,(+)-CSL最弱.

  16. Emergent chiral spin liquid: fractional quantum Hall effect in a kagome Heisenberg model.

    Science.gov (United States)

    Gong, Shou-Shu; Zhu, Wei; Sheng, D N

    2014-09-10

    The fractional quantum Hall effect (FQHE) realized in two-dimensional electron systems under a magnetic field is one of the most remarkable discoveries in condensed matter physics. Interestingly, it has been proposed that FQHE can also emerge in time-reversal invariant spin systems, known as the chiral spin liquid (CSL) characterized by the topological order and the emerging of the fractionalized quasiparticles. A CSL can naturally lead to the exotic superconductivity originating from the condense of anyonic quasiparticles. Although CSL was highly sought after for more than twenty years, it had never been found in a spin isotropic Heisenberg model or related materials. By developing a density-matrix renormalization group based method for adiabatically inserting flux, we discover a FQHE in a spin-½ isotropic kagome Heisenberg model. We identify this FQHE state as the long-sought CSL with a uniform chiral order spontaneously breaking time reversal symmetry, which is uniquely characterized by the half-integer quantized topological Chern number protected by a robust excitation gap. The CSL is found to be at the neighbor of the previously identified Z2 spin liquid, which may lead to an exotic quantum phase transition between two gapped topological spin liquids.

  17. Comparative analysis of Notch1 and Notch2 binding sites in the genome of BxPC3 pancreatic cancer cells

    Science.gov (United States)

    Liu, Hao; Zhou, Ping; Lan, Hong; Chen, Jia; Zhang, Yu-xiang

    2017-01-01

    Notch signaling plays a key role in the development of pancreatic cancer. Among the four identified Notch receptors, Notch1 and Notch2 share the highest homology. Notch1 has been reported to be an oncogene but some reports indicate that Notch2, not Notch1, plays a key role in pancreatic carcinogenesis. As both are transcription factors, examination of their genomic binding sites might reveal interesting functional differences between them. Notch proteins do not have DNA-binding domain. In the canonical Notch signaling pathway, ligand binding induces the release and nuclear translocation of Notch receptor intracellular domains (NICDs), which then interact with the transcription factor CSL, resulting in subsequent activation of the canonical Notch target genes. We investigated the binding site profiles of Notch1and Notch2 in the BxPC3 genome using CHIP-Seq and bioinfomatics. We found that Notch1, Notch2 and CSL generally bound to different target genes. We also found that only a small subset of Notch1 and Notch2 binding sites overlap with that of CSL, but about half of the CSL binding overlap with that of Notch1 or Notch2, indicating most Notch signaling activities are CSL-independent.

  18. Comparative analysis of Notch1 and Notch2 binding sites in the genome of BxPC3 pancreatic cancer cells.

    Science.gov (United States)

    Liu, Hao; Zhou, Ping; Lan, Hong; Chen, Jia; Zhang, Yu-Xiang

    2017-01-01

    Notch signaling plays a key role in the development of pancreatic cancer. Among the four identified Notch receptors, Notch1 and Notch2 share the highest homology. Notch1 has been reported to be an oncogene but some reports indicate that Notch2, not Notch1, plays a key role in pancreatic carcinogenesis. As both are transcription factors, examination of their genomic binding sites might reveal interesting functional differences between them. Notch proteins do not have DNA-binding domain. In the canonical Notch signaling pathway, ligand binding induces the release and nuclear translocation of Notch receptor intracellular domains (NICDs), which then interact with the transcription factor CSL, resulting in subsequent activation of the canonical Notch target genes. We investigated the binding site profiles of Notch1and Notch2 in the BxPC3 genome using CHIP-Seq and bioinfomatics. We found that Notch1, Notch2 and CSL generally bound to different target genes. We also found that only a small subset of Notch1 and Notch2 binding sites overlap with that of CSL, but about half of the CSL binding overlap with that of Notch1 or Notch2, indicating most Notch signaling activities are CSL-independent.

  19. Walking the bridge: Nursing students' learning in clinical skill laboratories.

    Science.gov (United States)

    Ewertsson, Mona; Allvin, Renée; Holmström, Inger K; Blomberg, Karin

    2015-07-01

    Despite an increasing focus on simulation as a learning strategy in nursing education, there is limited evidence on the transfer of simulated skills into clinical practice. Therefore it's important to increase knowledge of how clinical skills laboratories (CSL) can optimize students' learning for development of professional knowledge and skills, necessary for quality nursing practice and for patient safety. Thus, the aim was to describe nursing students' experiences of learning in the CSL as a preparation for their clinical practice. Interviews with 16 students were analysed with content analysis. An overall theme was identified - walking the bridge - in which the CSL formed a bridge between the university and clinical settings, allowing students to integrate theory and practice and develop a reflective stance. The theme was based on categories: conditions for learning, strategies for learning, tension between learning in the skills laboratory and clinical settings, and development of professional and personal competence. The CSL prepared the students for clinical practice, but a negative tension between learning in CSL and clinical settings was experienced. However, this tension may create reflection. This provides a new perspective that can be used as a pedagogical approach to create opportunities for students to develop their critical thinking.

  20. Caspian Sea level changes during the last millennium: historical and geological evidences from the south Caspian Sea

    Directory of Open Access Journals (Sweden)

    A. Naderi Beni

    2013-03-01

    Full Text Available Historical literature may constitute a valuable source of information to reconstruct sea level changes. Here, historical documents and geological records have been combined to reconstruct Caspian sea-level (CSL changes during the last millennium. In addition to a literature survey, new data from two short sediment cores were obtained from the south-eastern Caspian coast to identify coastal change driven by water-level changes. Two articulated bivalve shells from the marine facies were radiocarbon dated and calibrated to establish a chronology and to compare them with historical findings. The overall results indicate a high-stand during the Little Ice Age, up to −19 m, with a −28 m low-stand during the Medieval Climate Anomaly, while presently the CSL stands at −26.5 m. A comparison of the CSL curve with other lake systems and proxy records suggests that the main sea-level oscillations are essentially paced by solar irradiance. Although the major controller of the long-term CSL changes is driven by climatological factors, the seismicity of the basin could create locally changes in base level. These local base-level changes should be considered in any CSL reconstruction.

  1. Caspian sea-level changes during the last millennium: historical and geological evidence from the south Caspian Sea

    Directory of Open Access Journals (Sweden)

    A. Naderi Beni

    2013-07-01

    Full Text Available Historical literature may constitute a valuable source of information to reconstruct sea-level changes. Here, historical documents and geological records have been combined to reconstruct Caspian sea-level (CSL changes during the last millennium. In addition to a comprehensive literature review, new data from two short sediment cores were obtained from the south-eastern Caspian coast to identify coastal change driven by water-level changes and to compare the results with other geological and historical findings. The overall results indicate a high-stand during the Little Ice Age, up to −21 m (and extra rises due to manmade river avulsion, with a −28 m low-stand during the Medieval Climate Anomaly, while presently the CSL stands at −26.5 m. A comparison of the CSL curve with other lake systems and proxy records suggests that the main sea-level oscillations are essentially paced by solar irradiance. Although the major controller of the long-term CSL changes is driven by climatological factors, the seismicity of the basin creates local changes in base level. These local base-level changes should be considered in any CSL reconstruction.

  2. Dual Mechanism of Interleukin-3 Receptor Blockade by an Anti-Cancer Antibody

    Directory of Open Access Journals (Sweden)

    Sophie E. Broughton

    2014-07-01

    Full Text Available Interleukin-3 (IL-3 is an activated T cell product that bridges innate and adaptive immunity and contributes to several immunopathologies. Here, we report the crystal structure of the IL-3 receptor α chain (IL3Rα in complex with the anti-leukemia antibody CSL362 that reveals the N-terminal domain (NTD, a domain also present in the granulocyte-macrophage colony-stimulating factor (GM-CSF, IL-5, and IL-13 receptors, adopting unique “open” and classical “closed” conformations. Although extensive mutational analyses of the NTD epitope of CSL362 show minor overlap with the IL-3 binding site, CSL362 only inhibits IL-3 binding to the closed conformation, indicating alternative mechanisms for blocking IL-3 signaling. Significantly, whereas “open-like” IL3Rα mutants can simultaneously bind IL-3 and CSL362, CSL362 still prevents the assembly of a higher-order IL-3 receptor-signaling complex. The discovery of open forms of cytokine receptors provides the framework for development of potent antibodies that can achieve a “double hit” cytokine receptor blockade.

  3. Neutrino emissivities and bulk viscosity in neutral two flavor quark matter

    CERN Document Server

    Berdermann, J; Fischer, T; Kachanovich, A

    2016-01-01

    We study thermodynamic and transport properties for the isotropic color-spin-locking (iso-CSL) phase of two-flavor superconducting quark matter under compact star constraints within a NJL-type chiral quark model. Chiral symmetry breaking and the phase transition to superconducting quark matter leads to a density dependent change of quark masses, chemical potentials and diquark gap. A self-consistent treatment of these physical quantities influences on the microscopic calculations of transport properties. We present results for the iso-CSL direct URCA emissivities and bulk viscosities, which fulfill the constraints on quark matter derived from cooling and rotational evolution of compact stars. We compare our results with the phenomenologically successful, but yet heuristic 2SC+X phase. We show that the microscopically founded iso-CSL phase can replace the purely phenomenological 2SC+X phase in modern simulations of the cooling evolution for compact stars with color superconducting quark matter interior.

  4. Proceedings 8th Workshop on Fixed Points in Computer Science

    CERN Document Server

    Miller, Dale; 10.4204/EPTCS.77

    2012-01-01

    This volume contains the proceedings of the Eighth Workshop on Fixed Points in Computer Science which took place on 24 March 2012 in Tallinn, Estonia as an ETAPS-affiliated workshop. Past workshops have been held in Brno (1998, MFCS/CSL workshop), Paris (2000, LC workshop), Florence (2001, PLI workshop), Copenhagen (2002, LICS (FLoC) workshop), Warsaw (2003, ETAPS workshop), Coimbra (2009, CSL workshop), and Brno (2010, MFCS-CSL workshop). Fixed points play a fundamental role in several areas of computer science and logic by justifying induction and recursive definitions. The construction and properties of fixed points have been investigated in many different frameworks such as: design and implementation of programming languages, program logics, and databases. The aim of this workshop is to provide a forum for researchers to present their results to those members of the computer science and logic communities who study or apply the theory of fixed points.

  5. A Materials Life Cycle Assessment of a Net-Zero Energy Building

    Directory of Open Access Journals (Sweden)

    Laura A. Schaefer

    2013-02-01

    Full Text Available This study analyzed the environmental impacts of the materials phase of a net-zero energy building. The Center for Sustainable Landscapes (CSL is a three-story, 24,350 square foot educational, research, and administrative office in Pittsburgh, PA, USA. This net-zero energy building is designed to meet Living Building Challenge criteria. The largest environmental impacts from the production of building materials is from concrete, structural steel, photovoltaic (PV panels, inverters, and gravel. Comparing the LCA results of the CSL to standard commercial structures reveals a 10% larger global warming potential and a nearly equal embodied energy per square feet, largely due to the CSL’s PV system. As a net-zero energy building, the environmental impacts associated with the use phase are expected to be very low relative to standard structures. Future studies will incorporate the construction and use phases of the CSL for a more comprehensive life cycle perspective.

  6. Detecting continuous spontaneous localization with charged bodies in a Paul trap

    Science.gov (United States)

    Li, Ying; Steane, Andrew M.; Bedingham, Daniel; Briggs, G. Andrew D.

    2017-03-01

    Continuous spontaneous localization (CSL) is a model that captures the effects of a class of extensions to quantum theory which are expected to result from quantum gravity and is such that wave-function collapse is a physical process. The rate of such a process could be very much lower than the upper bounds set by searches to date and yet still modify greatly the interpretation of quantum mechanics and solve the quantum measurement problem. Consequently experiments are sought to explore this. We describe an experiment that has the potential to extend sensitivity to CSL by many orders of magnitude. The method is to detect heating of the motion of charged macroscopic objects confined in a Paul trap. We discuss the detection and the chief noise sources. We find that CSL with standard parameters could be observed using a vibration-isolated ion trap of size 1 cm at ultralow pressure with optical interferometric detection.

  7. Effect of calcifying bacteria on permeation properties of concrete structures.

    Science.gov (United States)

    Achal, V; Mukherjee, A; Reddy, M S

    2011-09-01

    Microbially enhanced calcite precipitation on concrete or mortar has become an important area of research regarding construction materials. This study examined the effect of calcite precipitation induced by Sporosarcina pasteurii (Bp M-3) on parameters affecting the durability of concrete or mortar. An inexpensive industrial waste, corn steep liquor (CSL), from starch industry was used as nutrient source for the growth of bacteria and calcite production, and the results obtained with CSL were compared with those of the standard commercial medium. Bacterial deposition of a layer of calcite on the surface of the specimens resulted in substantial decrease of water uptake, permeability, and chloride penetration compared with control specimens without bacteria. The results obtained with CSL medium were comparable to those obtained with standard medium, indicating the economization of the biocalcification process. The results suggest that calcifying bacteria play an important role in enhancing the durability of concrete structures.

  8. Kagome Chiral Spin Liquid as a Gauged U(1) Symmetry Protected Topological Phase.

    Science.gov (United States)

    He, Yin-Chen; Bhattacharjee, Subhro; Pollmann, Frank; Moessner, R

    2015-12-31

    While the existence of a chiral spin liquid (CSL) on a class of spin-1/2 kagome antiferromagnets is by now well established numerically, a controlled theoretical path from the lattice model leading to a low-energy topological field theory is still lacking. This we provide via an explicit construction starting from reformulating a microscopic model for a CSL as a lattice gauge theory and deriving the low-energy form of its continuum limit. A crucial ingredient is the realization that the bosonic spinons of the gauge theory exhibit a U(1) symmetry protected topological (SPT) phase, which upon promoting its U(1) global symmetry to a local gauge structure ("gauging"), yields the CSL. We suggest that such an explicit lattice-based construction involving gauging of a SPT phase can be applied more generally to understand topological spin liquids.

  9. Neutrino emissivities and bulk viscosity in neutral two-flavor quark matter

    Science.gov (United States)

    Berdermann, J.; Blaschke, D.; Fischer, T.; Kachanovich, A.

    2016-12-01

    We study thermodynamic and transport properties for the isotropic color-spin-locking (iso-CSL) phase of two-flavor superconducting quark matter under compact star constraints within a Nambu-Jona-Lasinio-type chiral quark model. Chiral symmetry breaking and the phase transition to superconducting quark matter leads to a density dependent change of quark masses, chemical potentials, and diquark gap. A self-consistent treatment of these physical quantities influences the microscopic calculations of transport properties. We present results for the iso-CSL direct URCA emissivities and bulk viscosities, which fulfil the constraints on quark matter derived from cooling and rotational evolution of compact stars. We compare our results with the phenomenologically successful, but yet heuristic 2 SC +X phase. We show that the microscopically founded iso-CSL phase can replace the purely phenomenological 2 SC +X phase in modern simulations of the cooling evolution for compact stars with color-superconducting quark matter interior.

  10. Kagome Chiral Spin Liquid as a Gauged U (1 ) Symmetry Protected Topological Phase

    Science.gov (United States)

    He, Yin-Chen; Bhattacharjee, Subhro; Pollmann, Frank; Moessner, R.

    2015-12-01

    While the existence of a chiral spin liquid (CSL) on a class of spin-1 /2 kagome antiferromagnets is by now well established numerically, a controlled theoretical path from the lattice model leading to a low-energy topological field theory is still lacking. This we provide via an explicit construction starting from reformulating a microscopic model for a CSL as a lattice gauge theory and deriving the low-energy form of its continuum limit. A crucial ingredient is the realization that the bosonic spinons of the gauge theory exhibit a U (1 ) symmetry protected topological (SPT) phase, which upon promoting its U (1 ) global symmetry to a local gauge structure ("gauging"), yields the CSL. We suggest that such an explicit lattice-based construction involving gauging of a SPT phase can be applied more generally to understand topological spin liquids.

  11. Corn steep liquor and fermented ammoniated condensed whey as protein sources for lactating cows and yearling heifers grazing winter native range

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, J.J.; Lusby, K.S.; Horn, G.W.; Dvorak, M.J.

    1982-06-01

    Corn steep liquor (CSL) and fermented ammoniated condensed whey (FACW) were compared to cottonseed meal (CSM) as protein sources for wintering 61 lactating first-calf Hereford heifers and 32 yearling Hereford heifers on native range. Cattle were allotted by weight and individually fed 6 days per week for 12 weeks one of four protein treatments: negative control (NC), positive control (PC), CSL and FACW to provide .7, 1.5, .15 and 1.5 lb crude protein (CP) per day, respectively, to the lacating heifers and .2, .4, .4 and .4lb cP per day, respectively, to the yearling heifers. CMS was supplied in the CSL and FACW treatments at the same level as in the negative control. Lactating heifers fed the NC lost more (P less than .005) weight and body condition (120 lb and 1.6 units) than those fed the PC (45.8 lb and .9 units). Weight and condition losses were similar (P more than .05) for lactating heifers fed PC, CSL and FACW. Yearling heifers fed the NC lost more (P less than .005) weight than those fed the PC (49.4 vs 10.6 lb). Yearling heifers fed CSL and FACW gained more (P less than .005) weight than those fed the PC (17.6 and 9.3 vs - 10.6 lb). Feeding CSL resulted in signficantly lower rumen pH, lower ruminal acetate and higher ruminal butyrate, isovalerate and caproate levels than did feeding either control. Supplementing with FACW produced significantly lower rumen pH, higher rumen ammonia and soluble carbohydrate levels, lower ruminal acetate, and higher ruminal propionate and butyrate concentrations than did either control supplement. Corn steep liquor and FDCW appear to be effective protein sources for cows and heifers grazing winter native range.

  12. Prevention of Hereditary Angioedema Attacks with a Subcutaneous C1 Inhibitor.

    Science.gov (United States)

    Longhurst, Hilary; Cicardi, Marco; Craig, Timothy; Bork, Konrad; Grattan, Clive; Baker, James; Li, Huamin H; Reshef, Avner; Bonner, James; Bernstein, Jonathan A; Anderson, John; Lumry, William R; Farkas, Henriette; Katelaris, Constance H; Sussman, Gordon L; Jacobs, Joshua; Riedl, Marc; Manning, Michael E; Hebert, Jacques; Keith, Paul K; Kivity, Shmuel; Neri, Sergio; Levy, Donald S; Baeza, Maria L; Nathan, Robert; Schwartz, Lawrence B; Caballero, Teresa; Yang, William; Crisan, Ioana; Hernandez, María D; Hussain, Iftikhar; Tarzi, Michael; Ritchie, Bruce; Králíčková, Pavlina; Guilarte, Mar; Rehman, Syed M; Banerji, Aleena; Gower, Richard G; Bensen-Kennedy, Debra; Edelman, Jonathan; Feuersenger, Henrike; Lawo, John-Philip; Machnig, Thomas; Pawaskar, Dipti; Pragst, Ingo; Zuraw, Bruce L

    2017-03-23

    Background Hereditary angioedema is a disabling, potentially fatal condition caused by deficiency (type I) or dysfunction (type II) of the C1 inhibitor protein. In a phase 2 trial, the use of CSL830, a nanofiltered C1 inhibitor preparation that is suitable for subcutaneous injection, resulted in functional levels of C1 inhibitor activity that would be expected to provide effective prophylaxis of attacks. Methods We conducted an international, prospective, multicenter, randomized, double-blind, placebo-controlled, dose-ranging, phase 3 trial to evaluate the efficacy and safety of self-administered subcutaneous CSL830 in patients with type I or type II hereditary angioedema who had had four or more attacks in a consecutive 2-month period within 3 months before screening. We randomly assigned the patients to one of four treatment sequences in a crossover design, each involving two 16-week treatment periods: either 40 IU or 60 IU of CSL830 per kilogram of body weight twice weekly followed by placebo, or vice versa. The primary efficacy end point was the number of attacks of angioedema. Secondary efficacy end points were the proportion of patients who had a response (≥50% reduction in the number of attacks with CSL830 as compared with placebo) and the number of times that rescue medication was used. Results Of the 90 patients who underwent randomization, 79 completed the trial. Both doses of CSL830, as compared with placebo, reduced the rate of attacks of hereditary angioedema (mean difference with 40 IU, -2.42 attacks per month; 95% confidence interval [CI], -3.38 to -1.46; and mean difference with 60 IU, -3.51 attacks per month; 95% CI, -4.21 to -2.81; Phereditary angioedema, the prophylactic use of a subcutaneous C1 inhibitor twice weekly significantly reduced the frequency of acute attacks. (Funded by CSL Behring; COMPACT EudraCT number, 2013-000916-10 , and ClinicalTrials.gov number, NCT01912456 .).

  13. Should blunt segmental vascular renal injuries be considered an American Association for the Surgery of Trauma Grade 4 renal injury?

    Science.gov (United States)

    Malaeb, Bahaa; Figler, Brad; Wessells, Hunter; Voelzke, Bryan B

    2014-02-01

    Renal segmental vascular injury (SVI) following blunt abdominal trauma is not part of the original American Association for the Surgery of Trauma (AAST) renal injury grading system. Recent recommendations support classifying SVI as an AAST Grade 4 (G4) injury. Our primary aim was to compare outcomes following blunt renal SVI and blunt renal collecting system lacerations (CSLs). We hypothesize that renal SVI fare well with conservative management alone and should be relegated a less severe renal AAST grade. We retrospectively identified patients with SVI and G4 CSL admitted to a Level 1 trauma center between 2003 and 2010. Penetrating trauma was excluded. Need for surgical intervention, length of stay, kidney salvage (>25% renal preservation on renography 6-12 weeks after injury), and delayed complication rates were compared between the SVI and CSL injuries. Statistical analysis used χ, Fisher's exact, and t tests. A total of 56 patients with SVI and 88 patients with G4 CSL sustained blunt trauma. Age, Injury Severity Score (ISS), and length of stay were similar for the two groups. Five patients in each group died of concomitant, nonrenal injuries. In the G4 CSL group, 15 patients underwent major interventions, and 32 patients underwent minor interventions. Only one patient in the SVI group underwent a major intervention. The renal salvage rate was 85.7% following SVI versus 62.5% following CSL (p = 0.107). Overall, surgical interventions are significantly lower among the SVI cohort than the G4 CSL cohort. Further analysis using a larger cohort of patients is recommended before revising the current renal grading system. Adding SVI as a G4 injury could potentially increase the heterogeneity of G4 injuries and decrease the ability of the AAST renal injury grading system to predict outcomes, such as nephrectomy rate. Epidemiologic study, level IV.

  14. Latitudinal range influences the seasonal variation in the foraging behavior of marine top predators.

    Directory of Open Access Journals (Sweden)

    Stella Villegas-Amtmann

    Full Text Available Non-migratory resident species should be capable of modifying their foraging behavior to accommodate changes in prey abundance and availability associated with a changing environment. Populations that are better adapted to change will have higher foraging success and greater potential for survival in the face of climate change. We studied two species of resident central place foragers from temperate and equatorial regions with differing population trends and prey availability associated to season, the California sea lion (Zalophus californianus (CSL whose population is increasing and the endangered Galapagos sea lion (Zalophus wollebaeki (GSL whose population is declining. To determine their response to environmental change, we studied and compared their diving behavior using time-depth recorders and satellite location tags and their diet by measuring C and N isotope ratios during a warm and a cold season. Based on latitudinal differences in oceanographic productivity, we hypothesized that the seasonal variation in foraging behavior would differ for these two species. CSL exhibited greater seasonal variability in their foraging behavior as seen in changes to their diving behavior, foraging areas and diet between seasons. Conversely, GSL did not change their diving behavior between seasons, presenting three foraging strategies (shallow, deep and bottom divers during both. GSL exhibited greater dive and foraging effort than CSL. We suggest that during the warm and less productive season a greater range of foraging behaviors in CSL was associated with greater competition for prey, which relaxed during the cold season when resource availability was greater. GSL foraging specialization suggests that resources are limited throughout the year due to lower primary production and lower seasonal variation in productivity compared to CSL. These latitudinal differences influence their foraging success, pup survival and population growth reflected in

  15. Effect of different levels of corn steep liquor addition on fermentation characteristics and aerobic stability of fresh rice straw silage

    Directory of Open Access Journals (Sweden)

    Xinxin Li

    2016-12-01

    Full Text Available The object of this study was to determine the proper mixing ratio of fresh rice straw to corn steep liquor (CSL to obtain a high protein content silage feed. The following experimental silages were generated: the control (C1, composed of fresh rice straw without CSL additive, mixed with CSL in the ratios of 4:1 (C4, 3:1 (C3 and 2:1 (C2. Lactic acid bacteria (LAB inoculant was applied at the rate of 50 mL/kg (fresh basis of forage to achieve a final application rate of 1 × 106 cfu/g of fresh matter (FM. Duplicate silos for each treatment were opened after 0, 3, 7, 10, 20, 30, 45 and 60 d for microbiological and chemical analysis. The results showed that the addition of CSL significantly increased crude protein (CP contents, and decreased neutral detergent fiber (NDF and acid detergent fiber (ADF contents of treatments after 60 d of ensiling (P < 0.05. The lactic acid contents in C4 and C3 were significantly higher than that in C1 (P < 0.05. In summary, mixing fresh rice straw with CSL at addition levels of 4:1 (C4 and 3:1 (C3 can improve the fermentation quality and nutrient composition of fresh rice straw silage. However, a large proportion of CSL (C3 had a negative impact on the aerobic stability of fresh rice straw.

  16. Berberine Nanosuspension Enhances Hypoglycemic Efficacy on Streptozotocin Induced Diabetic C57BL/6 Mice

    Directory of Open Access Journals (Sweden)

    Zhiping Wang

    2015-01-01

    Full Text Available Berberine (Ber, an isoquinoline derivative alkaloid and active ingredient of Coptis, has been demonstrated to possess antidiabetic activities. However its low oral bioavailability restricts its clinical application. In this report, Ber nanosuspension (Ber-NS composed of Ber and D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS was prepared by high pressure homogenization technique. Antidiabetic effects of Ber-NS relative to efficacy of bulk Ber were evaluated in streptozotocin (STZ induced diabetic C57BL/6 mice. The particle size and zeta potential of Ber-NS were 73.1 ± 3.7 nm and 6.99 ± 0.17 mV, respectively. Ber-NS (50 mg/kg treatment via oral gavage for 8 weeks resulted in a superior hypoglycemic and total cholesterol (TC and body weight reduction effects compared to an equivalent dose of bulk Ber and metformin (Met, 300 mg/kg. These data indicate that a low dosage Ber-NS decreases blood glucose and improves lipid metabolism in type 2 diabetic C57BL/6 mice. These results suggest that the delivery of Ber as a nanosuspension is a promising approach for treating type 2 diabetes.

  17. Berberine nanosuspension enhances hypoglycemic efficacy on streptozotocin induced diabetic C57BL/6 mice.

    Science.gov (United States)

    Wang, Zhiping; Wu, Junbiao; Zhou, Qun; Wang, Yifei; Chen, Tongsheng

    2015-01-01

    Berberine (Ber), an isoquinoline derivative alkaloid and active ingredient of Coptis, has been demonstrated to possess antidiabetic activities. However its low oral bioavailability restricts its clinical application. In this report, Ber nanosuspension (Ber-NS) composed of Ber and D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) was prepared by high pressure homogenization technique. Antidiabetic effects of Ber-NS relative to efficacy of bulk Ber were evaluated in streptozotocin (STZ) induced diabetic C57BL/6 mice. The particle size and zeta potential of Ber-NS were 73.1 ± 3.7 nm and 6.99 ± 0.17 mV, respectively. Ber-NS (50 mg/kg) treatment via oral gavage for 8 weeks resulted in a superior hypoglycemic and total cholesterol (TC) and body weight reduction effects compared to an equivalent dose of bulk Ber and metformin (Met, 300 mg/kg). These data indicate that a low dosage Ber-NS decreases blood glucose and improves lipid metabolism in type 2 diabetic C57BL/6 mice. These results suggest that the delivery of Ber as a nanosuspension is a promising approach for treating type 2 diabetes.

  18. The Bernese Emigration to the United States, 1870–1930: A Quantitative Analysis of Economic Factors

    Directory of Open Access Journals (Sweden)

    Simon Geissbühler

    1999-10-01

    Full Text Available The United States was the most important destination for emigrants from the Swiss canton of Bern during the period of mass emigration in the late 19th and the early 20th century. The present article looks at the economic factors leading to this mass emigration. Using bivariate correlations, this study demonstrates that quantitative analysis is a powerful tool in historical emigration research. The data underlines the two following theses. First, the better the economy in Bern, the lower the rate of emigration to the United States. Secondly, the better the economy in the United States, the higher the rate of emigration from Bern. Hence, both pull and push factors played an important role determining emigration from Bern to the United States. The most closely related to the rate of emigration were the independent variables emigration to the USA in year t-1, the investments in structural engineering in Bern, railroad construction in the USA and the number of Bernese on welfare. The results clearly show that Bernese emigration was primarily a socio-economic mass movement.

  19. Impact of the European Russia drought in 2010 on the Caspian Sea level

    Directory of Open Access Journals (Sweden)

    K. Arpe

    2012-01-01

    Full Text Available The hydrological budgets of the Volga basin (VB and the Caspian Sea (CS have been analysed. The components of the water balance for the CS were calculated for the period 1993 to 2010 with emphasis on summer 2010 when a severe drought developed over European Russia.

    A drop in precipitation over the VB in July 2010 occurs simultaneously with a decrease in evaporation for the same area, an increase of evaporation over the CS itself and a drop of the Caspian Sea level (CSL. The drop in the precipitation over the VB cannot lead to an instantaneous drop of the CSL because the precipitated water needs some months to reach the CS. The delay is estimated here to be 1 to 3 months for excessive precipitation in summer, longer for deficient precipitation and for winter cases. However, the evaporation over the CS itself is considered to be responsible for a simultaneous drop of the CSL from July to September 2010. The impact on the CSL from the precipitation deficit over the VB occurs in the months following the drought. The water deficit from July to September 2010 calculated from the anomalous precipitation minus evaporation over the VB would decrease the CSL by 22 cm, of which only 2 cm had been observed until the end of September (observed Volga River discharge anomaly. So the remaining drop of 20 cm can be expected in the months to follow if no other anomalies happen. In previous studies the precipitation over the VB has been identified as the main cause for CSL changes, but here from a 10 cm drop from beginning of July to end of September, 6 cm can be directly assigned to the enhanced evaporation over the CS itself and 2 cm due to reduced precipitation over the CS.

    Further periods with strong changes of the CSL are also investigated, which provide some estimates concerning the accuracy of the analysis data. The investigation was possible due to the new ECMWF interim reanalysis data which are used to provide data also for sensitive

  20. Experimental bounds on collapse models from gravitational wave detectors

    Science.gov (United States)

    Carlesso, Matteo; Bassi, Angelo; Falferi, Paolo; Vinante, Andrea

    2016-12-01

    Wave function collapse models postulate a fundamental breakdown of the quantum superposition principle at the macroscale. Therefore, experimental tests of collapse models are also fundamental tests of quantum mechanics. Here, we compute the upper bounds on the collapse parameters, which can be inferred by the gravitational wave detectors LIGO, LISA Pathfinder, and AURIGA. We consider the most widely used collapse model, the continuous spontaneous localization (CSL) model. We show that these experiments exclude a huge portion of the CSL parameter space, the strongest bound being set by the recently launched space mission LISA Pathfinder. We also rule out a proposal for quantum-gravity-induced decoherence.

  1. Can the Gulf Stream induce coherent short-term fluctuations in sea level along the US East Coast? A modeling study

    Science.gov (United States)

    Ezer, Tal

    2016-02-01

    Much attention has been given in recent years to observations and models that show that variations in the transport of the Atlantic Meridional Overturning Circulation (AMOC) and in the Gulf Stream (GS) can contribute to interannual, decadal, and multi-decadal variations in coastal sea level (CSL) along the US East Coast. However, less is known about the impact of short-term (time scales of days to weeks) fluctuations in the GS and their impact on CSL anomalies. Some observations suggest that these anomalies can cause unpredictable minor tidal flooding in low-lying areas when the GS suddenly weakens. Can these short-term CSL variations be attributed to changes in the transport of the GS? An idealized numerical model of the GS has been set up to test this proposition. The regional model uses a 1/12° grid with a simplified coastline to eliminate impacts from estuaries and small-scale coastal features and thus isolate the GS impact. The GS in the model is driven by inflows/outflows, representing the Florida Current (FC), the Slope Current (SC), and the Sargasso Sea (SS) flows. Forcing the model with an oscillatory FC transport with a period of 2, 5, and 10 days produced coherent CSL variations from Florida to the Gulf of Maine with similar periods. However, when imposing variations in the transports of the SC or the SS, they induce CSL variations only north of Cape Hatteras. The suggested mechanism is that variations in GS transport produce variations in sea level gradient across the entire GS length and this large-scale signal is then transmitted into the shelf by the generation of coastal-trapped waves (CTW). In this idealized model, the CSL variations induced by variations of ˜10 Sv in the transport of the GS are found to resemble CSL variations induced by ˜5 m s-1 zonal wind fluctuations, though the mechanisms of wind-driven and GS-driven sea level are quite different. Better understanding of the relation between variations in offshore currents and CSL will help

  2. Crystal interface and high-resolution electron microscopy—the best partner

    OpenAIRE

    Ichinose, H.

    2000-01-01

    Several contributions of HRTEM on the interface science are reviewed in chronological order. The first contribution of HRTEM is the observation of gold (113)Σ°11 boundary, giving experimental proof of the CSL model. An observation of the asymmetric (112)Σ°3 boundary follows. A SiC grain boundary is effectively assessed not by the density of CSL point but the number of dangling bonds in the boundary. A ZnO/Pd interface provides an example that a misfit dislocation does not necessarily accommod...

  3. The installation of solar collectors in buildings: Now without building approval; Einbau von Sonnenkollektoren in Gebaeude: Jetzt ohne Baubewilligung

    Energy Technology Data Exchange (ETDEWEB)

    Humm, O.

    1995-01-01

    A modification in the building law of Bern simplifies the installation of plants for the utilization of solar energy: Beginning from January 1995, in the canton of Bern, energy collectors outside from protectional zones or protectional objects are free of approval, as far as they correspond to certain structural requirements - the so-called recommendations. This ``Bernese solution`` has a significance for the whole of Switzerland, since several cantons strive for equal or at least similar deregulations. The journal ``HAUS TECH`` presents the Bernese model. (orig.) [Deutsch] Eine Aenderung in der bernischen Baugesetzgebung vereinfacht die Installation von Anlagen zur Nutzung von Sonnenenergie: Ab 1. Januar 1995 sind im Kanton Bern Energiekollektoren ausserhalb von Schutzzonen oder Schutzobjekten bewilligungsfrei, sofern sie gewissen gestalterischen Anforderungen - den sogenannten Empfehlungen - entsprechen. Die ``Berner Loesung`` hat gesamtschweizerische Bedeutung, weil mehrere Kantone gleiche oder zumindest aehnliche Deregulierungen anstreben. ``HAUS TECH`` stellt das Berner Modell vor. (orig.)

  4. Johannes Geiss: Explorer of the Elements

    Science.gov (United States)

    Zurbuchen, Thomas H.

    2007-06-01

    The extraordinary life and scientific achievements of Johannes Geiss span an almost impossible breadth of scientific topics, from the study of rocks to tenuous plasmas, from volcanoes to meteorites. But, his impact also extends way beyond the field of science. Professor Geiss is a well-known teacher and a highly successful science leader whose impact has been felt at the University of Bern, in Switzerland, and around the globe. We present here a brief summary of this highly successful career via a pictorial overview and a movie compiled by a former student who had the good luck to work with Professor Geiss during his years at the University of Bern.

  5. Albert Einstein's close friends and colleagues from the Patent Office

    CERN Document Server

    Weinstein, Galina

    2012-01-01

    In the Patent Office Einstein hatched his most beautiful ideas, and there he spent his "Happy Bern Years". These wonderful ideas led to his miraculous year works of 1905. Einstein was not an expert in academic matters, and he was out of academic world. Neither did he meet influential professors, or attend academic meetings. He discussed his ideas with his close friends and colleagues from the Patent Office. In 1907 he finally got his foot into the academic doorway; Einstein became a privatdozent and gave lectures at the University of Bern. However, his first students consisted again of his two close friends and another colleague from the Patent Office.

  6. Management de la innovación en las empresas pequeñas y medianas: resultados de un estudio explorativo

    OpenAIRE

    Thom, Norbert; Müller Vásquez Callo, Renato C.

    2013-01-01

    To a large extent, small and medium-sized enterprises are the economic basis of Swiss Society and its Economy. And thereby they support the country’s innovative capacity. This empirical research carried out by the University of Berne within the Canton of Bern gives a clear evaluation of the importance of innovation and of its management within small and medium-sized enterprises. This paper reflects the great importance of the topic, as well as its strengths and weaknesses. It also proposes su...

  7. New Issues in Intellectual Property Law in Indonesia

    Directory of Open Access Journals (Sweden)

    M. Hawin

    2012-02-01

    Full Text Available This article compares the provisions on moral rights in Indonesian Copyright Act, Copyright Bill, and The Berne Convention. The legality of parallel importation and the sui generis protection of traditional knowledge are also observed by referring to the Copyright Bill and Traditional Knowledge Bill. Tulisan ini membandingkan pengaturan mengenai hak moral menurut Undangundang Hak Cipta, RUU Hak Cipta dan Konvensi Berne. Selain itu, tulisan ini juga mengkaji legalitas impor paralel dan perlindungan sui generis terhadap pengetahuan tradisional dengan merujuk kepada RUU Hak Cipta dan RUU Pengetahuan Tradisional.

  8. Statistical optimization of medium composition for bacterial cellulose production by Gluconacetobacter hansenii UAC09 using coffee cherry husk extract--an agro-industry waste.

    Science.gov (United States)

    Rani, Mahadevaswamy Usha; Rastogi, Navin K; Appaiah, K A Anu

    2011-07-01

    During the production of grape wine, the formation of thick leathery pellicle/bacterial cellulose (BC) at the airliquid interface was due to the bacterium, which was isolated and identified as Gluconacetobacter hansenii UAC09. Cultural conditions for bacterial cellulose production from G. hansenii UAC09 were optimized by central composite rotatable experimental design. To economize the BC production, coffee cherry husk (CCH) extract and corn steep liquor (CSL) were used as less expensive sources of carbon and nitrogen, respectively. CCH and CSL are byproducts from the coffee processing and starch processing industry, respectively. The interactions between pH (4.5- 8.5), CSL (2-10%), alcohol (0.5-2%), acetic acid (0.5- 2%), and water dilution rate to CCH ratio (1:1 to 1:5) were studied using response surface methodology. The optimum conditions for maximum BC production were pH (6.64), CSL (10%), alcohol (0.5%), acetic acid (1.13%), and water to CCH ratio (1:1). After 2 weeks of fermentation, the amount of BC produced was 6.24 g/l. This yield was comparable to the predicted value of 6.09 g/l. This is the first report on the optimization of the fermentation medium by RSM using CCH extract as the carbon source for BC production by G. hansenii UAC09.

  9. Two Years of the STEREO Heliospheric Imagers: Invited Review

    Science.gov (United States)

    2009-01-01

    University of Birmingham, both in the UK, and the Centre Spatial de Liege (CSL). Belgium, and the US Naval Research Laboratory (NRL), Washington DC, USA. The...Ger- many), Centre Spatial de Liege (Belgium), Institut d’Optique Theorique et Appliquee (France), and Institut d’Astrophysique Spatiale (France

  10. Study of CME Propagation in the Inner Heliosphere: SOHO LAS, SMEI and STERO HI Observations of the January 2007 Events

    Science.gov (United States)

    2009-01-01

    both in the United Kingdom, the Centre Spatial de Liege (CSL), Belgium, and the US Naval Research Laboratory (NRL), Washington DC, USA. The STEREO...Centre Spatial de Liege (Belgium), Institut d’Optique Theorique et Appliquee (France), and Institut d’Astrophysiquc Spatiale (France). We also

  11. The Impact of Geometry on Observations of CME Brightness and Propagation

    Science.gov (United States)

    2009-01-01

    Sonnensystemforschung (Germany), Centre Spatial de Liege (Belgium), Instilitt d’Optique Theorique et Appliquee (France), and Institut...the University of Birmingham, both in the United Kingdom, the Centre Spatial de Liege (CSL). Belgium, and the US Naval Research Laboratory (NRL

  12. A Review of Stroke Order in "Hanzi" Handwriting

    Science.gov (United States)

    Zhang, Haiwei

    2014-01-01

    This article reviews the current research on stroke order of "hanzi" (as used to write the Chinese, Japanese and Korean languages) in teaching Chinese as a second language (CSL). Based on an extensive review of current research on stroke order, it first discusses the importance and difficulty of stroke order in "hanzi"…

  13. Sports Sponsorship iPhox Aims for the Big Leagues

    Institute of Scientific and Technical Information of China (English)

    MICHAEL O'NEILL

    2006-01-01

    @@ The announcement in March that iPhox would be the new sponsor of the troubled China Super League (CSL) came as a big surprise to many familiar with Chinese football. In just its third season since a 2004 revamp,the football league had been running without a sponsor after Siemens pulled out at the start of 2005.

  14. Influence of SiC grain boundary character on fission product transport in irradiated TRISO fuel

    Science.gov (United States)

    Lillo, T. M.; van Rooyen, I. J.

    2016-05-01

    In this study, the fission product precipitates at silicon carbide grain boundaries from an irradiated TRISO particle were identified and correlated with the associated grain boundary characteristics. Precession electron diffraction in the transmission electron microscope provided the crystallographic information needed to identify grain boundary misorientation and boundary type (i.e., low angle, random high angle or coincident site lattice (CSL)-related). The silicon carbide layer was found to be composed mainly of twin boundaries and small fractions of random high angle and low angle grain boundaries. Most fission products were found at random, high-angle grain boundaries, with small fractions at low-angle and CSL-related grain boundaries. Palladium (Pd) was found at all types of grain boundaries while Pd-uranium and Pd-silver precipitates were only associated with CSL-related and random, high-angle grain boundaries. Precipitates containing only Ag were found only at random, high-angle grain boundaries, but not at low angle or CSL-related grain boundaries.

  15. Understanding Learning and Learning Design in MOOCs: A Measurement-Based Interpretation

    Science.gov (United States)

    Milligan, Sandra; Griffin, Patrick

    2016-01-01

    The paper describes empirical investigations of how participants in a MOOC learn, and the implications for MOOC design. A learner capability to generate higher order learning in MOOCs--called crowd-sourced learning (C-SL) capability--was defined from learning science literature. The capability comprised a complex yet interrelated array of…

  16. The manufacturing, assembly and acceptance testing of the breadboard Cryogenic Optical Delay Line for DARWIN

    NARCIS (Netherlands)

    Dool, T.C. van den; Kamphues, F.G.; Gielesen, W.L.M.; Dorrepaal, M.; Doelman, N.J.; Loix, N.; Verschueren, J.P.; Kooijman, P.P.; Visser, M.; Velsink, G.; Fleury, K.

    2005-01-01

    TNO, in cooperation with Micromega-Dynamics, SRON, Dutch Space and CSL, has developed a compact breadboard cryogenic Optical Delay Line for use in future space interferometry missions. The work is performed under ESA contract in preparation for the DARWIN mission. The breadboard delay line is repres

  17. "Advanced Manufacturing Methods for Systems of Nanospacecrafts".

    OpenAIRE

    Rochus, Pierre

    2014-01-01

    Space instrumentation and Space Environmental testing activities at CSL Dreams, a priori expectations and space specificities Advanced Manufacturing Techniques considered in our studies First steps realizations 15 years ago More concrete and more recent examples Conclusions and future activities Peer reviewed

  18. NCBI nr-aa BLAST: CBRC-OSAT-07-0044 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OSAT-07-0044 gb|AAL25131.1|AF432502_1 cellulose synthase-like protein OsCslF1 ...[Oryza sativa] dbj|BAC83318.1| putative cellulose synthase [Oryza sativa (japonica cultivar-group)] AAL25131.1 0.0 62% ...

  19. Chiral spin liquid in a frustrated anisotropic kagome Heisenberg model.

    Science.gov (United States)

    He, Yin-Chen; Sheng, D N; Chen, Yan

    2014-04-04

    Kalmeyer-Laughlin (KL) chiral spin liquid (CSL) is a type of quantum spin liquid without time-reversal symmetry, and it is considered as the parent state of an exotic type of superconductor--anyon superconductor. Such an exotic state has been sought for more than twenty years; however, it remains unclear whether it can exist in a realistic system where time-reversal symmetry is breaking (T breaking) spontaneously. By using the density matrix renormalization group, we show that KL CSL exists in a frustrated anisotropic kagome Heisenberg model, which has spontaneous T breaking. We find that our model has two topological degenerate ground states, which exhibit nonvanishing scalar chirality order and are protected by finite excitation gap. Furthermore, we identify this state as KL CSL by the characteristic edge conformal field theory from the entanglement spectrum and the quasiparticles braiding statistics extracted from the modular matrix. We also study how this CSL phase evolves as the system approaches the nearest-neighbor kagome Heisenberg model.

  20. Relationships between Reading Comprehension and Its Components in Young Chinese-as-a-Second-Language Learners

    Science.gov (United States)

    Wong, Yu Ka

    2017-01-01

    Based on the Simple View of Reading model, this study examines the relationships among Chinese reading comprehension and its two componential processes, Chinese character reading and listening comprehension, in young learners of Chinese as a second language (CSL) using a longitudinal design. Using relevant measures, a sample of 142 senior primary…

  1. DISLOCATION STRUCTURE OF FCC COPPER/BCC IRON INTERPHASE INTERFACES

    OpenAIRE

    C Forwood

    1990-01-01

    The Burgers vectors and geometry of the interfacial dislocation structure in fcc/bcc interfaces in a Cu+25 wt.% Fe alloy are analysed using TEM and the technique of image matching. The Burgers vectors are shown to be differences of the Cu and Fe lattice vectors and the interfacial structure is interpreted in terms of a CSL/DSC model.

  2. Studies on the antimicrobial effect of corn steep liquor on some ...

    African Journals Online (AJOL)

    ROFIAT

    2014-01-08

    Jan 8, 2014 ... fermentation of maize during ogi production is. Lactobacillus ... activities of CSL. One milliliter (1 ml) of broth culture of each of the test organisms ... noted that none of the bacteria studied was recovered after 48 h except ...

  3. Reduction in Rotavirus-associated Acute Gastroenteritis Following Introduction of Rotavirus Vaccine Into Australia's National Childhood Vaccine Schedule

    NARCIS (Netherlands)

    Buttery, Jim P.; Lambert, Stephen B.; Grimwood, Keith; Nissen, Michael D.; Field, Emma J.; Macartney, Kristine K.; Akikusa, Jonathan D.; Kelly, Julian J.; Kirkwood, Carl D.

    2011-01-01

    Introduction: Rotavirus vaccines were introduced into the funded Australian National Immunization Program (NIP) in July 2007. Due to purchasing arrangements, individual states and territories chose either a 2-dose RV1 (Rotarix, GSK) regimen or 3-dose RV5 (Rotateq, Merck/CSL) regimen. This allowed co

  4. Reduction in Rotavirus-associated Acute Gastroenteritis Following Introduction of Rotavirus Vaccine Into Australia's National Childhood Vaccine Schedule

    NARCIS (Netherlands)

    Buttery, Jim P.; Lambert, Stephen B.; Grimwood, Keith; Nissen, Michael D.; Field, Emma J.; Macartney, Kristine K.; Akikusa, Jonathan D.; Kelly, Julian J.; Kirkwood, Carl D.

    Introduction: Rotavirus vaccines were introduced into the funded Australian National Immunization Program (NIP) in July 2007. Due to purchasing arrangements, individual states and territories chose either a 2-dose RV1 (Rotarix, GSK) regimen or 3-dose RV5 (Rotateq, Merck/CSL) regimen. This allowed

  5. Strategies for reducing supplemental medium cost in bioethanol production from waste house wood hydrolysate by ethanologenic Escherichia coli: inoculum size increase and coculture with Saccharomyces cerevisiae.

    Science.gov (United States)

    Okuda, Naoyuki; Ninomiya, Kazuaki; Katakura, Yoshio; Shioya, Suteaki

    2008-02-01

    In this paper, we report a simultaneous realization of both efficient ethanol production and saving medium nutrient (corn steep liquor [CSL]) during bioethanol fermentation of overliming-treated hydrolysate of waste house wood (WHW) using ethanologenic Escherichia coli KO11. In cultivation using WHW hydrolysate supplemented with 4% (v/v) CSL and 0.2 g-dry cell weight (DCW)/l E. coli KO11 cells, the overall ethanol yield reached 84% of the theoretical value at 61 h. When we conducted the cultivation with 1% CSL to reduce the supplemental medium cost, the overall ethanol yield remained in the range of 66-72% even at 90 h. We proposed two alternative methods for increasing the overall yield even with 1% CSL. The first method involved increasing the inoculum size of E. coli KO11 up to 0.8 g-DCW/l, where 83% of the overall yield was attained at 60 h of cultivation. The second method involved the coculture of 0.2 g-DCW/l E. coli KO11 together with 0.02 g-DCW/l of Saccharomyces cerevisiae TJ1, and the overall yield reached 81% at 47 h of cultivation.

  6. Service-Learning Programs and the Knowledge Economy: Exploring the Tensions

    Science.gov (United States)

    Taylor, Alison

    2017-01-01

    Community service-learning (CSL) programs are proliferating in Canadian higher education. University programs promote students' experiential learning in community as part of a course; students most often engage in unpaid work in not-for-profit organizations and reflect on that experience in relation to their classroom learning. However, programs…

  7. Corn steep liquor as a nutrition adjunct for the production of Aspergillus niger lipase and hydrolysis of oils thereof.

    Science.gov (United States)

    Edwinoliver, N G; Thirunavukarasu, K; Purushothaman, S; Rose, C; Gowthaman, M K; Kamini, N R

    2009-11-25

    Corn steep liquor (CSL) has been used as a nutrition adjunct for the production of an extracellular lipase from Aspergillus niger, which has immense importance as an additive in laundry detergent formulations. A five-level four-factorial central composite design was chosen to determine the optimal medium components with four critical variables, namely, CSL, NH4H2PO4, Na2HPO4, and sesame oil, that were found to be influential for lipase production by the classical one-factor-at-a-time method. The model suggested that all of the factors chosen had a significant impact on lipase production, and the optimum values of the influential parameters were CSL, 2.0%, w/v; NH4H2PO4, 0.05%, w/v; Na2HPO4, 0.75%, w/v; and sesame oil, 2.0%, w/v, with an activity of 26.7 U/mL at 48 h and 30 degrees C, which was 2.16-fold higher than the initial activity (12 U/mL) obtained by the conventional one-factor-at-a-time method. Furthermore, the enzyme has good potential for the hydrolysis of vegetable oils and fish oils, and a hydrolytic ratio of 88.73% was obtained with palm oil at 48 h. The utilization of CSL and sesame oil for lipase production from A. niger makes the process green, because both are renewable substrates and economically viable at an industrial scale.

  8. Gender issues in computer-supported learning

    Directory of Open Access Journals (Sweden)

    Cathy Gunn

    2002-12-01

    Full Text Available Contemporary research identifies significant gender-related differences in performance and interaction style in computer-supported learning (CSL environments. Evidence suggests that initial perceptions of these environments as democratic and offering equal opportunities to all students were flawed because interactions that take place through electronic channels lose none of the sociocultural complexity or gender imbalance that already exists within society. This paper presents a summary of gender-related issues identified by international research and academic practice together with the opinions expressed by participants in a discussion forum staged at ALT-C in 2001. Two main questions were addressed during the conference forum. Firstly, if computer access and literacy levels are assumed to be equalizing as the literature suggests, how can educational designers using CSL technologies best serve all student groups? Secondly, does the existence of gender-based differences in behaviour and interaction style in CSL environments mean that any student group is disadvantaged? The paper concludes with suggestions about how educational designers might increase the flexibility of CSL courses to offer equal opportunities to all students. A number of issues for further research are also identified.

  9. Environmental Security in Botswana

    Science.gov (United States)

    2011-10-01

    take a generation to recover . For this reason the president of Botswana has made environmental security a national priority and is utilizing a...poachers in late June, 2010. CSL-4 The focus of these seminars has included conservation of ground water, collection of rainwater and overall water

  10. Quantitative and Descriptive Comparison of Four Acoustic Analysis Systems: Vowel Measurements

    Science.gov (United States)

    Burris, Carlyn; Vorperian, Houri K.; Fourakis, Marios; Kent, Ray D.; Bolt, Daniel M.

    2014-01-01

    Purpose: This study examines accuracy and comparability of 4 trademarked acoustic analysis software packages (AASPs): Praat, WaveSurfer, TF32, and CSL by using synthesized and natural vowels. Features of AASPs are also described. Method: Synthesized and natural vowels were analyzed using each of the AASP's default settings to secure 9…

  11. Recombination by grain-boundary type in CdTe

    Energy Technology Data Exchange (ETDEWEB)

    Moseley, John, E-mail: john.moseley@nrel.gov; Ahrenkiel, Richard K. [National Renewable Energy Laboratory, 15013 Denver West Parkway, Golden, Colorado 80401 (United States); Colorado School of Mines, 1500 Illinois Street, Golden, Colorado 80401 (United States); Metzger, Wyatt K.; Moutinho, Helio R.; Guthrey, Harvey L.; Al-Jassim, Mowafak M. [National Renewable Energy Laboratory, 15013 Denver West Parkway, Golden, Colorado 80401 (United States); Paudel, Naba; Yan, Yanfa [Department of Physics & Astronomy, University of Toledo, Toledo, Ohio 43606 (United States)

    2015-07-14

    We conducted cathodoluminescence (CL) spectrum imaging and electron backscatter diffraction on the same microscopic areas of CdTe thin films to correlate grain-boundary (GB) recombination by GB “type.” We examined misorientation-based GB types, including coincident site lattice (CSL) Σ = 3, other-CSL (Σ = 5–49), and general GBs (Σ > 49), which make up ∼47%–48%, ∼6%–8%, and ∼44%–47%, respectively, of the GB length at the film back surfaces. Statistically averaged CL total intensities were calculated for each GB type from sample sizes of ≥97 GBs per type and were compared to the average grain-interior CL intensity. We find that only ∼16%–18% of Σ = 3 GBs are active non-radiative recombination centers. In contrast, all other-CSL and general GBs are observed to be strong non-radiative centers and, interestingly, these GB types have about the same CL intensity. Both as-deposited and CdCl{sub 2}-treated films were studied. The CdCl{sub 2} treatment reduces non-radiative recombination at both other-CSL and general GBs, but GBs are still recombination centers after the CdCl{sub 2} treatment.

  12. Investigating Mobile-Assisted Oral Feedback in Teaching Chinese as a Second Language

    Science.gov (United States)

    Xu, Qi; Peng, Hongying

    2017-01-01

    This article reports on an exploratory study investigating mobile-assisted oral feedback in teaching Chinese as a second language (CSL). It is aimed at exploring the characteristics of mobile-assisted feedback on oral production with the smartphone social communication app WeChat as a case in point and examining learners' perceptions of…

  13. The development of a cryogenic optical delay line for DARWIN

    NARCIS (Netherlands)

    Dool, T.C. van den; Kamphues, F.G.

    2005-01-01

    TNO, in cooperation with Micromega-Dynamics, SRON, Dutch Space and CSL, has designed a compact breadboard cryogenic delay line for use in future space interferometry missions. The work is performed under ESA contract in preparation for the DARWIN mission. The breadboard (BB) delay line is

  14. Anomalous electrodynamics of neutral pion matter in strong magnetic fields

    Science.gov (United States)

    Brauner, Tomáš; Kadam, Saurabh V.

    2017-03-01

    The ground state of quantum chromodynamics in sufficiently strong external magnetic fields and at moderate baryon chemical potential is a chiral soliton lattice (CSL) of neutral pions [1]. We investigate the interplay between the CSL structure and dynamical electromagnetic fields. Our main result is that in presence of the CSL background, the two physical photon polarizations and the neutral pion mix, giving rise to two gapped excitations and one gapless mode with a nonrelativistic dispersion relation. The nature of this mode depends on the direction of its propagation, interpolating between a circularly polarized electromagnetic wave [2] and a neutral pion surface wave, which in turn arises from the spontaneously broken translation invariance. Quite remarkably, there is a neutral-pion-like mode that remains gapped even in the chiral limit, in seeming contradiction to the Goldstone theorem. Finally, we have a first look at the effect of thermal fluctuations of the CSL, showing that even the soft nonrelativistic excitation does not lead to the Landau-Peierls instability. However, it leads to an anomalous contribution to pressure that scales with temperature and magnetic field as T 5/2( B/f π )3/2.

  15. Privilege, power, and public health programs: a student perspective on deconstructing institutional racism in community service learning.

    Science.gov (United States)

    Taboada, Arianna

    2011-01-01

    The Association of Schools of Public Health has identified "diversity and culture" as 1 of 7 crosscutting competencies that public health students are expected to achieve. This competency is traditionally incorporated into the curriculum through a community service-learning (CSL) component that aims to expose students to racial/ethnic health disparities. However, this model of CSL is problematic because although students are directly engaging with community members, it does not ensure long-term sustainable changes or benefits for the host community. Moreover, academic institutions have developed significant critiques of traditional CSL models where white middle-class students engage with low-income clients and communities of color, potentially reinforcing Eurocentric power and privilege. As such, public health programs require a shift in both pedagogy and curricula that more directly addresses underlying institutional racism in health disparities. Consistent with the principles of public health, a social justice framework is imperative in teaching cultural competency and should facilitate discussion of racial injustice and privilege in the students' own lives. This brief presents an autobiographical personal narrative of my experiences with CSL as a racial/ethnic minority student in a California graduate school of public health. Although autoethnography is inherently limited, this brief highlights my observations of the limitations of the service-learning model to adequately educate students on the intersection of racism and health outcomes. In addition, the brief includes suggestions for creating inclusive curricula that critically examine issues of privilege, oppression, and power dynamics related to race/ethnicity.

  16. Continuous Biometric Authentication for Authorized Aircraft Personnel: A Proposed Design

    Science.gov (United States)

    2003-06-01

    Skin tone may also affect whether the user is accepted or rejected by the system as well. For example, there may be a person whose skin pigment does...facial and scar/mark/ tattoo image data. The ANSI/NIST ITL 1a-1997 standard is a revision of ANSI/NIST-CSL 1- 1993 which specifies a common format

  17. Towards building a prototype spin-logic device

    Science.gov (United States)

    Penumatcha, Ashish Verma

    Since the late 1980s, several key discoveries, such as Giant and Tunneling Magne- toresistance, and advances in magnetic materials have paved the way for exponentially higher bit-densities in magnetic storage. In particular, the discovery of Spin-Transfer Torque (STT) has allowed information to be written to individual magnets using spin-currents. This has replaced the more traditional Oersted-field control used in field-MRAMs and allowed further scaling of magnetic-memories. A less obvious con- sequence of STT is that it has made possible a logic-technology based on magnets controlled by spin-polarized currents. Charge-coupled Spin Logic (CSL) is one such device proposal that couples a giant spin Hall effect(GSHE) write-unit with a Mag- netic Tunnel Junction read-unit. Several theoretical reports have demonstrated that a CSL-style device can function as a fundamental building block for neuromorphic computing by harnessing the intrinsic properties of magnets. This thesis describes the working of a CSL device. Experimental progress towards building the individual components of CSL and also our efforts to integrate these components into a CSL prototype will be presented. In addition to the integration effort, this work also explores spin-injection from a GSHE metal to a nanoscale magnet through an intermediate non-magnetic metal. Our results indicate that with the right choice of intermediate layers, the spin-angular mo- mentum absorbed by the magnet can be increased without engineering the intrinsic spin Hall angle of the GSHE metal. Finally, this work also proposes a Schottky-barrier model to describe the current flow through low-dimensional semiconductors and uses it to extract the band gap of black-phosphorus thin-films in an attempt to characterize novel 2D-materials.

  18. Effects of Linker Length and Transient Secondary Structure Elements in the Intrinsically Disordered Notch RAM Region on Notch Signaling.

    Science.gov (United States)

    Sherry, Kathryn P; Johnson, Scott E; Hatem, Christine L; Majumdar, Ananya; Barrick, Doug

    2015-11-01

    Formation of the bivalent interaction between the Notch intracellular domain (NICD) and the transcription factor CBF-1/RBP-j, Su(H), Lag-1 (CSL) is a key event in Notch signaling because it switches Notch-responsive genes from a repressed state to an activated state. Interaction of the intrinsically disordered RBP-j-associated molecule (RAM) region of NICD with CSL is thought to both disrupt binding of corepressor proteins to CSL and anchor NICD to CSL, promoting interaction of the ankyrin domain of NICD with CSL through an effective concentration mechanism. To quantify the role of disorder in the RAM linker region on the effective concentration enhancement of Notch transcriptional activation, we measured the effects of linker length variation on activation. The resulting activation profile has general features of a worm-like chain model for effective concentration. However, deviations from the model for short sequence deletions suggest that RAM contains sequence-specific structural elements that may be important for activation. Structural characterization of the RAM linker with sedimentation velocity analytical ultracentrifugation and NMR spectroscopy reveals that the linker is compact and contains three transient helices and two extended and dynamic regions. To test if these secondary structure elements are important for activation, we made sequence substitutions to change the secondary structure propensities of these elements and measured transcriptional activation of the resulting variants. Substitutions to two of these nonrandom elements (helix 2, extended region 1) have effects on activation, but these effects do not depend on the nature of the substituting residues. Thus, the primary sequences of these elements, but not their secondary structures, are influencing signaling.

  19. A cytotoxic anti-IL-3Rα antibody targets key cells and cytokines implicated in systemic lupus erythematosus

    Science.gov (United States)

    Oon, Shereen; Huynh, Huy; Tai, Tsin Yee; Ng, Milica; Monaghan, Katherine; Biondo, Mark; Maraskovsky, Eugene; Nash, Andrew D.; Wicks, Ian P.; Wilson, Nicholas J.

    2016-01-01

    To date, the major target of biologic therapeutics in systemic lupus erythematosus (SLE) has been the B cell, which produces pathogenic autoantibodies. Recently, targeting type I IFN, which is elaborated by plasmacytoid dendritic cells (pDCs) in response to endosomal TLR7 and TLR9 stimulation by SLE immune complexes, has shown promising results. pDCs express high levels of the IL-3Rα chain (CD123), suggesting an alternative potential targeting strategy. We have developed an anti-CD123 monoclonal antibody, CSL362, and show here that it affects key cell types and cytokines that contribute to SLE. CSL362 potently depletes pDCs via antibody-dependent cell-mediated cytotoxicity, markedly reducing TLR7, TLR9, and SLE serum-induced IFN-α production and IFN-α-upregulated gene expression. The antibody also inhibits TLR7- and TLR9-induced plasmablast expansion by reducing IFN-α and IL-6 production. These effects are more pronounced than with IFN-α blockade alone, possibly because pDC depletion reduces production of other IFN subtypes, such as type III, as well as non-IFN proinflammatory cytokines, such as IL-6. In addition, CSL362 depletes basophils and inhibits IL-3 signaling. These effects were confirmed in cells derived from a heterogeneous population of SLE donors, various IFN-dependent autoimmune diseases, and healthy controls. We also demonstrate in vivo activity of CSL362 following its s.c. administration to cynomolgus monkeys. This spectrum of effects provides a preclinical rationale for the therapeutic evaluation of CSL362 in SLE. PMID:27699260

  20. Structure-function analysis of RBP-J-interacting and tubulin-associated (RITA) reveals regions critical for repression of Notch target genes.

    Science.gov (United States)

    Tabaja, Nassif; Yuan, Zhenyu; Oswald, Franz; Kovall, Rhett A

    2017-06-23

    The Notch pathway is a cell-to-cell signaling mechanism that is essential for tissue development and maintenance, and aberrant Notch signaling has been implicated in various cancers, congenital defects, and cardiovascular diseases. Notch signaling activates the expression of target genes, which are regulated by the transcription factor CSL (CBF1/RBP-J, Su(H), Lag-1). CSL interacts with both transcriptional corepressor and coactivator proteins, functioning as both a repressor and activator, respectively. Although Notch activation complexes are relatively well understood at the structural level, less is known about how CSL interacts with corepressors. Recently, a new RBP-J (mammalian CSL ortholog)-interacting protein termed RITA has been identified and shown to export RBP-J out of the nucleus, thereby leading to the down-regulation of Notch target gene expression. However, the molecular details of RBP-J/RITA interactions are unclear. Here, using a combination of biochemical/cellular, structural, and biophysical techniques, we demonstrate that endogenous RBP-J and RITA proteins interact in cells, map the binding regions necessary for RBP-J·RITA complex formation, and determine the X-ray structure of the RBP-J·RITA complex bound to DNA. To validate the structure and glean more insights into function, we tested structure-based RBP-J and RITA mutants with biochemical/cellular assays and isothermal titration calorimetry. Whereas our structural and biophysical studies demonstrate that RITA binds RBP-J similarly to the RAM (RBP-J-associated molecule) domain of Notch, our biochemical and cellular assays suggest that RITA interacts with additional regions in RBP-J. Taken together, these results provide molecular insights into the mechanism of RITA-mediated regulation of Notch signaling, contributing to our understanding of how CSL functions as a transcriptional repressor of Notch target genes. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  1. Buchbesprechungen

    OpenAIRE

    1995-01-01

    Sachssl, U. (1994): Selbstverletzendes Verhalten. Gottingen. Endres, M. (Hrsg.) (1994): Krisen im Jugendalter. München. Katzung, W. (1994): Drogen in Stichworten. Daten, Begriffe, Substanzen. Landsberg. Leuner, H (1994). Lehrbuch der katathym - imaginativen Psychotherapie, 3. korr. u erw. Auflage. Bern. Holtz K. L. (1994): Geistige Behinderung und soziale Kompetenz: Analyse und Integration psychologischer Konstrukte. Heidelberg.

  2. Quantum Simulation of Heterogeneous Electron Transfer Free Energies at the Water-Metal Interface

    Science.gov (United States)

    1994-05-06

    occurring, the potential was modified by the addition of a hard repulsive wall alog the 0-H bond, given by the funcional form 2h + Gh (l (,o.. - r(o...T. Hynes, in The Theory of Chemical Reactions, edited by M. Baer (CRC, Boca Raton, FL, 1985); B. J. Berne, in Multiple Timescales, edited by J. V

  3. Au CERN, la Boule d'Expo.02 pourrait trouver son équilibre financier

    CERN Document Server

    Stampfli, B

    2002-01-01

    "Avec l'aide de Berne, un projet en guise de beau cadeau pour fêter ses 50 ans. On le sait au coeur d'une grave crise financière, mais le CERN s'est quand même porté acquereur du Palais de l'Equilibre" (0.5 page)

  4. On the string-inspired approach to QED in external field

    CERN Document Server

    Shaisultanov, R Z

    1995-01-01

    Strassler's formulation of the string-derived Bern-Kosower formalism is extended to consider QED processes in homogeneous constant external field. A compact expression for the contribution of the one-loop with arbitrary number of external photon lines is given for scalar QED. Extension to spinor QED is shortly discussed.

  5. Competition between Public Supervision and Professional Management: An Ethnographic Study of School Governance Reforms in Switzerland

    Science.gov (United States)

    Hangartner, Judith; Svaton, Carla Jana

    2014-01-01

    This article discusses insights from an ethnographic study of local governance practices in the Canton of Bern, Switzerland, under changing policy conditions. Recent reforms introduced and strengthened the position of head teachers, enhanced the responsibility of the municipalities and introduced new quality management procedures in local…

  6. From Autonomy to Quality Management: NPM Impacts on School Governance in Switzerland

    Science.gov (United States)

    Hangartner, Judith; Svaton, Carla Jana

    2013-01-01

    This article reviews the impact of discourses on "New Public Management" (NPM) on compulsory schooling in Switzerland during the last two decades and traces its implementation in the Canton of Bern. The analysis suggests that while NPM reformers initially promoted increased school autonomy, the introduction of market elements and school…

  7. Perché è necessario capire il web

    CERN Multimedia

    Rosenthal, Edward C

    2007-01-01

    The birth of the cobweb of contents, the web 2.0, Wikipedia, the global collaboration, i blog, the net neutrality, the digital liberty and the future of the net: interview with Robert Cailliau, inventor of the WWW with Tim Bernes-Lee. (2 pages)

  8. 100eme anniversaire de la théorie de la relativité Une BD romande : Mélanges Einstein (Albert) et l'histoire de la physique

    CERN Multimedia

    Tesnier, Grégory

    2005-01-01

    2005 has been delcared "Year of Physics" by UNESCO and ONU to celebrate the 100th anniversary of the theory of relativity, elaborated by Einstein (who lived in Bern). To hon. Einstein, an historical comic strip has been published (1 page)

  9. Tõlkeloo arvukad dimensioonid / Hannu K. Riikonen

    Index Scriptorium Estoniae

    Riikonen, Hannu K.

    2012-01-01

    Arvustus: Antonie Chalvin, Anne Lange, Daniele Monticelli (Eds.) Between cultures and texts : itineraries in translation history = Entre les cultures et les textes : itinéraires en histoire de la traduction. Frankfurt am Main-Berlin-Bern-Bruxelles-New York-Oxford-Wien 2011

  10. Peat Deposits Of Light Ground Pocosin, Pamlico County, North Carolina

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The Light Ground Pocosin peat deposit is located in south central Pamlico County, 13 miles east of New Bern. Except for a narrow channel 8 to 12 feet deep, and two...

  11. Compacting coastal plain soils changes midrotation loblolly pine allometry by reducing root biomass

    Science.gov (United States)

    Kim H. Ludovici

    2008-01-01

    Factorial combinations of soil compaction and organic matter removal were replicated at the Long Term Site Productivity study in the Croatan National Forest, near New Bern, North Carolina, USA. Ten years after planting, 18 preselected loblolly pine (Pinus taeda L.) trees were destructively harvested to quantify treatment effects on total above- and...

  12. Anti-hepatocarcinoma effects of berberine nanosuspension against human HepG2 and Huh7 cells as well as H22 tumor bearing mice

    Science.gov (United States)

    Wang, Zhi-ping; Wu, Jun-biao; Zhou, Qun; Wang, Yi-fei; Chen, Tongsheng

    2014-09-01

    Hepatocarcinoma, a malignant cancer, threaten human life badly. It is a current issue to seek the effective natural remedy from plant to treat cancer due to the resistance of the advanced hepatocarcinoma to chemotherapy. Berberine (Ber), an isoquinoline derivative alkaloid, has a wide range of pharmacological properties and is considered to have anti-hepatocarcinoma effects. However its low oral bioavailability restricts its wide application. In this report, Ber nanosuspension (Ber-NS) composed of Ber and D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) was prepared by high pressure homogenization technique. Both in vitro and in vivo anti-hepatocarcinoma effects of Ber-NS relative to effcacy of bulk Ber were evaluated. The particle size and zeta potential of Ber-NS were 73.1 +/- 3.7 nm and 6.99 +/- 0.17 mV, respectively. Ber-NS exhibited significant inhibitory effects against human HepG2 and Huh7 cells, and the corresponding IC50 values were 8.1 and 4.7 μg/ml (18.3 and 6.5 μg/ml of Ber solution). In vivo studies also showed higher antitumor efficacy, and inhibition rates was 63.7% (41.4 % of Ber solution) at 100 mg/kg intragastric administration in the H22 solid tumor bearing mice. These results suggest that the delivery of Ber as a nanosuspension is a promising approach for treating hepatocarcinoma.

  13. Library science talks : eleventh season 2005

    CERN Multimedia

    2005-01-01

    The Swiss National Library in Berne, the Association of International Librarians and Information Specialists AILIS and the CERN Scientific Information Service are pleased to announce their 2005 series of Library Science Talks. The series offers library and archive staff the possibility of learning from and communicating with personalities in library services and organizations. The talks cover important and topical issues for librarians.

  14. Science and Technology Text Mining: Near-Earth Space

    Science.gov (United States)

    2003-07-21

    MISSOURI, UNIV OF BERNE, and UNIV OF ZURICH. Regions of interest closely associated with REMOTE SENSING include SENEGALESE SAHEL , ROSETTA PROMONTORY...TERRAIN DATA BASES, LAND DEGRADATION ASSESSMENT, ACREAGE ESTIMATION, SOIL SALINITY , SNOWMELT RUNOFF, SNOW DEPTH, SEA-SURFACE VELOCITIES, SEA- ICE

  15. Linking Up the Alps: How Networks of Local Political Actors Build the Pan-Alpine Region

    Directory of Open Access Journals (Sweden)

    Clive H. Church

    2017-05-01

    Full Text Available Reviewed: Linking Up the Alps: How Networks of Local Political Actors Build the Pan-Alpine Region By Cristina Del Biaggio. Bern, Switzerland: Peter Lang, 2016. 370 pp. €52.50. ISBN 978-3-0343-1630-9.

  16. Coactivator Requirements for Serm Action

    Science.gov (United States)

    2005-06-01

    Berns EM, Klijn JG, Beex LV , Foekens Fluge 0, Pergamenschikov A, Williams C, Zhu SX, Lon- JA 2001 Tamoxifen resistance in breast cancer: elucidat- ning...G, Polyak K 2001 A SAGE (serial analysis of T, Kato S, Kawabe Y, Yanagisawa J 2003 Full activation gene expression) view of breast tumor progression

  17. Planetary Exploration, Horizon 2061: A Joint ISSI-Europlanet Community Foresight Exercise

    Science.gov (United States)

    Blanc, M.; Harri, A.-M.; Rodrigo, R.; Krupp, N.; Zarnecki, J.; Szego, K.; Horizon 2061 Working Group; Planetary Exploration Horizon 2061 Team

    2017-02-01

    This communication will be the first presentation of the outputs of a community forum organized in September 2016 in Bern by ISSI and Europlanet. It will present a foresight of the key questions that should drive planetary space missions up to the 2061 horizon.

  18. [Olaf Asendorf. Das Veto des Deutschen Ordens gegen die Erhöhung des Nikolaikirchturmes in Reval] / Paul Kaegbein

    Index Scriptorium Estoniae

    Kaegbein, Paul

    2006-01-01

    Arvustus: Olaf Asendorf. Das Veto des Deutschen Ordens gegen die Erhöhung des Nikolaikirchturmes in Reval. In: Asendorf: Mittelalterliche Türme im deutschordensland Preussen. Frankfurt am Main, Berlin, Bern, New York, Paris, Wien: Lang 1998. S. 105-109. Niguliste kiriku torni ehitusloost

  19. How Einstein Discovered "E[subscript 0] = mc[squared]"

    Science.gov (United States)

    Hecht, Eugene

    2012-01-01

    This paper traces Einstein's discovery of "the equivalence of mass [m] and energy ["E[subscript 0]"]." He came to that splendid insight in 1905 while employed by the Bern Patent Office, at which time he was not an especially ardent reader of physics journals. How then did the young savant, working outside of academia in semi-isolation, realize…

  20. Einstein's Century

    Institute of Scientific and Technical Information of China (English)

    Jeremy Laurance; 贾庆文

    2005-01-01

    Albert Einstein began working at the patent office in Bern, Switzerland, a little more than a century ago. He had flunked the entrance exam for the Swiss Federal Insitute of Technology and took the job evaluating inventions because it paid a regular salary.

  1. A course in amplitudes

    Science.gov (United States)

    Taylor, Tomasz R.

    2017-05-01

    This a pedagogical introduction to scattering amplitudes in gauge theories. It proceeds from Dirac equation and Weyl fermions to the two pivot points of current developments: the recursion relations of Britto, Cachazo, Feng and Witten, and the unitarity cut method pioneered by Bern, Dixon, Dunbar and Kosower. In ten lectures, it covers the basic elements of on-shell methods.

  2. [Book review] Developments in biological standardization (Vol. 49): Fish Biologics: Seriodiagnostics and Vaccines, edited by W. Hennessen and D. P. Andersen

    Science.gov (United States)

    Anderson, D.P.

    1981-01-01

    Review of: Developments in Biologicals, Vol. 49. Fish Biologics: Serodiagnostics and Vaccines. International Symposium, Leetown, W.Va., April 1981. Editor(s): Hennessen, W. (Bern); Andersen, D.P. (Leetown, W.Va.); Society/Societies: International Association of Biological Standardization, XII + 496 p., 90 fig., 110 tab., soft cover, 1981. ISBN: 978-3-8055-3471-0.

  3. Solar Cycle Effects on the Near-Earth Plasmas and Space Systems

    Science.gov (United States)

    1990-08-06

    1849, p. 234). 2. Schwabe, M., Bern Mitt (1851, p. 41). 3. Wolf, A. R., Astr Mitt. Eidg. Stern., Vol. 10 (1858, p. 6). 4. Galilei , G., "Letters on...Sunspots, 1612," in Discoveries and Opinions of Galileo , Dou- bleday and Company, Inc., New York, 1957, pp. 106-119. 5. Maggs, W, W, "Biggest Solar

  4. Please pass me the skin coloured crayon!

    DEFF Research Database (Denmark)

    Zimmermann, Martina; Levisen, Carsten; Beck, Thorhalla Gudmundsdottir

    2015-01-01

    This study explores the cultural semantics of colour words in the four urban, European communities of Munich, Berne, Aarhus, and Reykjavik, focussing on hautfarben (German), hutfarb (Bernese Swiss German), hudfarvet (Danish), and húðlitur (Icelandic), all of which can be translated as ‘skin colou...

  5. The Community-based Whole Magnetosphere Model

    Science.gov (United States)

    2011-11-15

    Tribulations and Exultations in Coupling Models of the Magnetosphere with Ionosphere-Thermosphere Models, Plane- tary Aeronomy ISSI Meeting, Bern...Exultations in Coupling Models of the Magnetosphere CWMM-19 Ridley CWMM Final Report with Ionosphere-Thermosphere Models, Plane- tary Aeronomy ISSI

  6. Drama in Life: The Uses of Communication in Society.

    Science.gov (United States)

    Combs, James E.; Mansfield, Michael W.

    Bringing together 35 of the most notable contributions of authors such as Kenneth Burke, Erving Goffman, and Eric Berne, this book provides an introduction to the dramaturgical perspective of social actions. Selections stem from the conception that many "real-life" actions and events can most adequately be understood in terms of drama. Included…

  7. Substrate-induced bulk alignment of liquid crystals

    DEFF Research Database (Denmark)

    Zhang, Zhengping; Chakrabarti, A.; Mouritsen, Ole G.;

    1996-01-01

    The Gay-Berne model for liquid crystals in the presence of a substrate surface is studied using the hybrid Monte Carlo method. A simple non-mean-field substrate-molecule potential is proposed to describe the effects of rubbed polymer-coated substrates on the liquid crystals. Effects...

  8. From Autonomy to Quality Management: NPM Impacts on School Governance in Switzerland

    Science.gov (United States)

    Hangartner, Judith; Svaton, Carla Jana

    2013-01-01

    This article reviews the impact of discourses on "New Public Management" (NPM) on compulsory schooling in Switzerland during the last two decades and traces its implementation in the Canton of Bern. The analysis suggests that while NPM reformers initially promoted increased school autonomy, the introduction of market elements and school…

  9. What's Slithering around on Your School Grounds? Transforming Student Awareness of Reptile & Amphibian Diversity

    Science.gov (United States)

    Tomasek, Terry M.; Matthews, Catherine E.; Hall, Jeff

    2005-01-01

    The protocols used in a research project on amphibian and reptile diversity at Cool Springs Environmental Education Center near New Bern, North Carolina is described. An increasing or stable number of amphibians and reptiles would indicate that the forest has a balance of invertebrates, leaf litter, moisture, pH, debris, burrows and habitat…

  10. Armillaria ectypa, a rare fungus of mire in Poland

    Directory of Open Access Journals (Sweden)

    Małgorzata Stasińska

    2015-08-01

    Full Text Available Armillaria ectypa is a saprotroph that occurs on active raised bogs and alkaline fens, as well as Aapa mires and transitional bogs. It is a very rare and threatened Eurasian species and one of the 33 fungal species proposed for inclusion into the Bern Convention. Its distribution in Poland, ecological notes and morphology of basidiocarp based on Polish specimens are presented.

  11. Clusters of galaxies: beyond the thermal view

    NARCIS (Netherlands)

    Kaastra, J.S.; Bykov, A.M.; Schindler, S.; Bleeker, J.A.M.; Borgani, S.; Diaferio, A.; Dolag, K.; Durret, F.; Nevalainen, J.; Ohashi, T.; Paerels, F.; Petrosian, V.; Rephaeli, Y.; Richter, P.; Schaye, J.; Werner, N.

    2008-01-01

    We present the work of an international team at the International Space Science Institute (ISSI) in Bern that worked together to review the current observational and theoretical status of the non-virialised X-ray emission components in clusters of galaxies. The subject is important for the study of

  12. The implementation of international nature conservation agreements in Europe: the case of the Netherlands

    NARCIS (Netherlands)

    Bennett, G.; Ligthart, S.S.H.

    2001-01-01

    Nature conservation policy in European countries is increasingly determined by the requirements of a wide range of international agreements. The most important are two EU directives (the Birds Directive and the Habitats Directive) and four conventions(the Ramsar Convention, the Bern Convention, the

  13. The Copyright Book: A Practical Guide. Fourth Edition.

    Science.gov (United States)

    Strong, William S.

    In response to important changes in copyright law as the United States accommodates itself to the Berne Convention and develops means to take account of new technologies, this guide puts these changes in a form and context that will make sense to persons who are concerned about their rights under the law. New material in the fourth edition of this…

  14. Computer-Based Instruction in Military Environments: Defense Research Series. Volume 1

    Science.gov (United States)

    1987-01-01

    the four best 2) in the class are Mark, Alicia, Wands, and Julio . (1) (2) coach [dl athlete [b) coaches (el athletes coach’s athlete’s Ccl 133...Dorner, D. et al. (1983). "Lohhausen: Vom Umgang mit Unbestimmtheit und Komplexitat." Bern : Verlag Hans Huber. Ford, E. & Tisak, M. (1983). A further

  15. Book Analysis: Terrorism - How the West Can Win.

    Science.gov (United States)

    1988-04-01

    Hearing... 98th Cong., 2d Sess., Washington DC: Government Printing Office, 1986. Articles and Periodicals Brady, Julio A. "The Threat of Terrorism to...Goldberg Eugene Rostow Walter Berns Burton M. Leiser Meir Shamgar VII. The Domestic Battle Edwin Meese, III William H. Webster Christian Lochte VIII

  16. Comparison of continuous in situ CO2 observations at Jungfraujoch using two different measurement techniques

    NARCIS (Netherlands)

    Schibig, M.F.; Steinbacher, M.; Buchmann, B.; Laan-Luijkx, van der I.T.; Laan, van der S.; Ranjan, S.; Leuenberger, M.C.

    2015-01-01

    Since 2004, atmospheric carbon dioxide (CO2) is being measured at the High Altitude Research Station Jungfraujoch by the division of Climate and Environmental Physics at the University of Bern (KUP) using a nondispersive infrared gas analyzer (NDIR) in combination with a paramagnetic O2 analyzer. In

  17. [Olaf Asendorf. Das Veto des Deutschen Ordens gegen die Erhöhung des Nikolaikirchturmes in Reval] / Paul Kaegbein

    Index Scriptorium Estoniae

    Kaegbein, Paul

    2006-01-01

    Arvustus: Olaf Asendorf. Das Veto des Deutschen Ordens gegen die Erhöhung des Nikolaikirchturmes in Reval. In: Asendorf: Mittelalterliche Türme im deutschordensland Preussen. Frankfurt am Main, Berlin, Bern, New York, Paris, Wien: Lang 1998. S. 105-109. Niguliste kiriku torni ehitusloost

  18. Diccionario de lingüística

    Directory of Open Access Journals (Sweden)

    Eduardo Miranda Nelson

    Full Text Available THEODOR LEWANDOWSKI, DICCIONARIO DE LINGUISTICA, Madrid, Ediciones Cátedra, S.A., 1982, XIV, 447 págs. Traducción del alemán por María Luz García-Denche y Enrique Bernárdez.

  19. Badger hair in shaving brushes comes from protected Eurasian badgers

    NARCIS (Netherlands)

    Domingo-Roura, X.; Marmi, J.; Ferrando, A.; López-Giráldez, F.; Macdonald, D.W.; Jansman, H.A.H.

    2006-01-01

    The Eurasian badger (Meles meles) is included in Appendix III of the Bern Convention and protected by national laws in many European countries. Badger hair is used to manufacture luxury shaving brushes, although it is frequently argued that the hog badger (Arctonyx collaris), which in Europe is an i

  20. Tõlkeloo arvukad dimensioonid / Hannu K. Riikonen

    Index Scriptorium Estoniae

    Riikonen, Hannu K.

    2012-01-01

    Arvustus: Antonie Chalvin, Anne Lange, Daniele Monticelli (Eds.) Between cultures and texts : itineraries in translation history = Entre les cultures et les textes : itinéraires en histoire de la traduction. Frankfurt am Main-Berlin-Bern-Bruxelles-New York-Oxford-Wien 2011

  1. Bam Earthquake in Iran

    CERN Multimedia

    2004-01-01

    Following their request for help from members of international organisations, the permanent Mission of the Islamic Republic of Iran has given the following bank account number, where you can donate money to help the victims of the Bam earthquake. Re: Bam earthquake 235 - UBS 311264.35L Bubenberg Platz 3001 BERN

  2. Academic Training: Climate change and challenges for the environment / POSTPONED!!!

    CERN Multimedia

    Françoise Benz

    2005-01-01

    2004-2005 ACADEMIC TRAINING PROGRAMME LECTURE SERIES 20, 21, 22 June 20, 21, 22 June, from 11:00 to 12:00 – Main Auditorium, bldg. 500 Climate change and challenges for the environment C. SCHLUECHTER / Univ. Bern, CH The Academic Training is postponed.

  3. Examining the Stroking Behavior of English, Persian, and Arabic School Teachers in Iran: A Mixed-Methods Study

    Science.gov (United States)

    Irajzad, Fatemeh; Pishghadam, Reza; Shahriari, Hesamoddin

    2017-01-01

    The quality of teacher-student relationships greatly affects students' academic life. Students need to be recognized by their teacher. One way through which such need may be fulfilled is receiving strokes (teacher attention). In a broad sense, stroke is known to be a unit of human recognition (Berne, 1988). Accordingly, the current mixed-methods…

  4. Core charge distribution and self assembly of columnar phases: the case of triphenylenes and azatriphenylenes

    Directory of Open Access Journals (Sweden)

    Berardi Roberto

    2007-06-01

    Full Text Available Abstract Background The relation betweeen the structure of discotic molecules and columnar properties, a crucial point for the realization of new advanced materials, is still largely unknown. A paradigmatic case is that hexa-alkyl-thio substituted triphenylenes present mesogenic behavior while the corresponding azatriphenylenes, similar in shape and chemical structure, but with a different core charge distribution, do not form any liquid crystalline mesophase. This study is aimed at investigating, with the help of computer simulations techniques, the effects on phase behaviour of changes of the charge distribution in the discotic core. Results We described the shape and the pair, dispersive and electrostatic, interactions of hexa alkyl triphenylenes by uniaxial Gay-Berne discs with embedded point charges. Gay-Berne parameters were deduced by fitting the dispersive energies obtained from an atomistic molecular dynamics simulation of a small sample of hexa-octyl-thio triphenylene molecules in columnar phase, while a genetic algorithm was used to get a minimal set of point charges that properly reproduces the ab anitio electrostatic potential. We performed Monte Carlo simulations of three molecular models: the pure Gay-Berne disc, used as a reference, the Gay-Berne disc with hexa-thio triphenylene point charges, the Gay-Berne disc with hexa-thio azatriphenylene point charges. The phase diagram of the pure model evidences a rich polymorphism, with isotropic, columnar and crystalline phases at low pressure, and the appearance of nematic phase at higher pressure. Conclusion We found that the intermolecular electrostatic potential among the cores is fundamental in sta-bilizing/destabilizing columnar phases; in particular the triphenylene charge distribution stabilizes the columnar structure, while the azatriphenylene distribution suppresses its formation in favor of the nematic phase. We believe the present model could be successfully employed as the

  5. Magnesium/calcium related neurological disorders in the ALS focus of the Kii Peninsula

    Energy Technology Data Exchange (ETDEWEB)

    Yasui, Masayuki; Yoshida, Munehito; Tamaki, Tetsuya; Taniguchi, Yasunori; Minamide, Akihito; Ota, Kiichiro [Wakayama Medical Coll. (Japan); Sasajima, Kazuhisa

    1997-01-01

    Current epidemiological surveys in the Western Pacific area and Kii Peninsula have suggested that low calcium(Ca), magnesium(Mg) and high aluminum(Al) and manganese(Mn) in river, soil and drinking water may be implicated in the pathogenetic process of amyotrophic lateral sclerosis(ALS) and Parkinsonism-dementia(PD). The condition of unbalanced minerals was experimentally mimicked in this study using rats. Male Wistar rats, weighing 200 g, were maintained for 90 days on the following diets: (A) standard diet, (B) low Ca diet, (C) low Ca-Mg diet, (D) low Ca-Mg diet with high Al. In the groups maintained on unbalanced mineral diets, Ca and Mg contents of the bones were lower than standard diet. On the other hand, Ca content of CNS showed higher values in the unbalanced diet groups than those in the standard diet group. This was determined by neutron activation analysis(NAA) at KUR. Also, Ca content in soft tissues of rats given unbalanced mineral diets was higher than those on standard diet. Mg content of soft tissues and spinal cord of rats was markedly lower in the low Ca-Mg plus high Al diet group than the other three groups as determined by inductively coupled plasma emission spectrometry(ICP). Six Kii cases with amyotrophic lateral sclerosis(ALS) also showed higher Ca and lower Mg contents in the CNS tissues than those of neurologically normal controls. The calcification of the spinal ligaments(CSL) has been reported in only 120 cases in the world and 28 cases of CSL in the Kii Peninsula have been found in the same foci as ALS. We analyzed Mg content of 7 spinal bones and 10 ligaments of the CSL and Ca content of 5 spinal bones compared with controls. The CSL showed lower values of Mg contents in bones and ligaments compared to controls. The Ca content in bones of CSL was significantly lower than that of controls. This suggests that the environmental factor may contribute to the pathogenesis of CSL due to low Ca and Mg intake as well as for ALS. (J.P.N.)

  6. 海绵蛋糕复合乳化剂研究%Study on Compound Emulsifier in Sponge Cake

    Institute of Scientific and Technical Information of China (English)

    王春艳; 钟耕

    2006-01-01

    在海绵蛋糕中加入单甘油酯、蔗糖酯、硬酯酰乳酸钙(CSL)及Tween-80等乳化剂均能提高蛋糕品质,通过正交试验研究不同配比乳化剂对提高海绵蛋糕感官品质和保鲜性不同作用,其中蛋糕保鲜性通过测定蛋糕水分活度变化和感官变化加以判断;试验结果表明,海绵蛋糕乳化剂最佳工艺配方为:单甘油酯0.2%、蔗糖酯0.2%、硬酯酰乳酸钙(CSL)0.4%、Tween-80为0.1%.

  7. Application of EBSD techniques in 2G high temperature superconducting coated conductors%EBSD技术在第二代高温超导涂层导体研究中的应用

    Institute of Scientific and Technical Information of China (English)

    尚都; 陈兴品; 陈雪; 张婧鹏; 刘庆

    2011-01-01

    本文利用EBSD技术研究涂层导体用的第二代高温超导镍钨合金基带的显微组织、平均晶粒尺寸、各织构组分含量、取向差分布和特殊晶界(CSL)等.并通过EBSD技术获得缓冲层的显微组织、旋转立方织构含量.%EBSD techniques have played an irreplaceable important role on the research of second generation ( 2G) superconductors. The EBSD technique was used to analyze the microstructure, average grain size, texture components content, misorientation distribution and grain boundaries (CSL) of nickel-tungsten substrates. In the meanwhile, the microstructure and rotate cube texture content information of buffer layer were measured by EBSD techniques.

  8. A newly isolated and identified vitamin B12 producing strain: Sinorhizobium meliloti 320.

    Science.gov (United States)

    Dong, Huina; Li, Sha; Fang, Huan; Xia, Miaomiao; Zheng, Ping; Zhang, Dawei; Sun, Jibin

    2016-10-01

    Vitamin B12 (Cobalamin, VB12) has several physiological functions and is widely used in pharmaceutical and food industries. A new unicellular species was extracted from China farmland, and the strain could produce VB12 which was identified by HPLC and HPLC-MS/MS. 16S rDNA analysis reveals this strain belongs to the species Sinorhizobium meliloti and we named it S. meliloti 320. Its whole genome information indicates that this strain has a complete VB12 synthetic pathway, which paves the way for further metabolic engineering studies. The optimal carbon and nitrogen sources are sucrose and corn steep liquor (CSL) plus peptone. The optimal combination of sucrose and CSL was obtained by response surface methodology as they are the most suitable carbon and nitrogen sources, respectively. This strain could produce 140 ± 4.2 mg L(-1) vitamin B12 after incubating for 7 days in the optimal medium.

  9. Study on Extraction and Activity of Polysaccharide Isolated from the Endophytic Fungus of Crocus sativus L.%一株藏红花内生真菌多糖的提取及其抗氧活性研究

    Institute of Scientific and Technical Information of China (English)

    陈吴海; 马帆; 陈钢; 温露

    2016-01-01

    文章通过对一株藏红花(Crocus sativus L.)内生真菌CSL-27进行液体发酵,利用醇沉的方法得到粗多糖.苯酚硫酸法测定了粗多糖的含量为60.63%,通过红外光谱对粗多糖的结构进行初步表征,结果表明其含有吡喃糖环和α、β两种糖苷键.此外,在溶血和脂质过氧化实验中,CSL-27粗多糖显示出较好的抗氧化活性,对应的EC50值分别为0 2和0.1 mg/mL.

  10. Crystal structure of caesium hydrogen (L)-aspartate and an overview of crystalline compounds of aspartic acid with inorganic constituents

    Energy Technology Data Exchange (ETDEWEB)

    Fleck, M. [Universitaet Wien (Austria). Institut fuer Mineralogie und Kristallographie; Emmerich, R.; Bohaty, L. [Universitaet zu Koeln (Austria). Institut fuer Kristallographie

    2010-08-15

    The crystal structure of the new polar compound caesium hydrogen (L)-aspartate, Cs(C{sub 4}H{sub 6}NO{sub 4}), (abbreviated: Cs(L -AspH)) was determined from single crystal X-ray diffraction data; it comprises two crystallographically different L -AspH anions that are connected via caesium cations to form a three dimensional framework. The Cs ions are irregularly sevenfold[Cs1O{sub 7}] respectively eightfold[Cs2O{sub 8}] coordinated to all {alpha}- and {beta}- carboxylate oxygen atoms. Cs(L -AspH) represents a novel structure type of its own, as do most compounds of (L)-aspartic acid with inorganic constituents. A brief summary of such structurally known aspartates is given. (copyright 2010 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  11. L-lactic acid production by Lactobacillus casei fermentation with corn steep liquor-supplemented acid-hydrolysate of soybean meal.

    Science.gov (United States)

    Li, Zheng; Ding, Shaofeng; Li, Zhaopeng; Tan, Tianwei

    2006-12-01

    Batch and fed-batch fermentation studies were performed to evaluate the potential of corn steep liquor (CSL)-supplemented acid-hydrolysate of soybean meal (AHSM) as an alternative to yeast extract (YE) for the production of L-lactic acid by Lactobacillus casei LA-04-1. The CSL-supplemented AHSM gave an outstanding result in supporting L-lactic acid production from glucose. In the exponential fed-batch fermentation, the concentration, yield and productivity of L-lactic acid were 162.5 g/L, 89.7% and 1.69 g/L per h, respectively, which were lower than those with 20 g/L YE (180 g/L, 90.3%, 2.14 g/L per h) after 96 h of fermentation. However, the raw material cost of the nitrogen resource was estimated as only 25% of that using the YE.

  12. Theoretical Studies of the Electronic Structure of Metal/Semiconductor/ Hydrogen Systems

    Science.gov (United States)

    1991-04-01

    and 3d-4d core electrons in Cs[l1J. Relativistic effects, especially important for Cs, were incorporated into the EP’s(141. Cluster binding energies...are especially affected by interlayer perturbations since among the Pb layer, IA and ID (Table II and Fig. I (b)]. the charge on these shifts by as...geometry optimimen. indicate the average inreinet in sii lbcrt8 titi enegin; between an evoluion f Oquanltuml con~finemenit effects. Surface: and

  13. Prove-Out RAM Assessment Report for the 155 mm M483 LAP Line at Lone Star Army Ammunition Plant

    Science.gov (United States)

    1978-11-01

    C o O- -— -. ^ — M -« U. 3 II O u. _ c c ca I (\\.irifcr-ecac — ( vnar ^ecac — fv.-3’tff"-(Vi-3-irerc-"t\\.-Jccc: — ir...70 Defense Documentation Center Cameron Station Alexandria, VA 22314 71-82 Weapon System Concept Team/CSL ATTN: DRDAR-ACW Aberdeen ...Proving Cround, MD 21010 83 Technical Library ATTN: DRDAR-CLJ-L Aberdeen Proving Cround, MD 21010 84 Technical Library ATTN: DRDAR

  14. [Indicators of infestation, colonization and infection of Triatoma dimidiata (Latreille) (Hemiptera: Reduviidae) in Campeche, México].

    Science.gov (United States)

    Hernández, Jorge L; Rebollar-Téllez, Eduardo A; Infante, Francisco; Morón, Alejandro; Castillo, Alfredo

    2010-01-01

    Triatoma dimidiata (Latreille) is considered to be one of the primary vectors of Chagas disease in Southern Mexico and Central America. The objective of the present study was to obtain ecological information on T. dimidiata in two rural communities of Campeche, Mexico, where the vector is poorly studied. Our work consisted of monthly samplings carried out during one-year time at three levels: sylvatic, peridomestic and intradomestic, in order to estimate the population abundance of this species and its rate of infection with Trypanosoma cruzi. Triatoma dimidiata was the unique vector of this disease collected in San Juan Bautista Sakcabchen (SJBS) and Crucero San Luis (CSL). The total of 145 individuals were captured in SJBS; from these, 26.9%, 20% and 53.1% were collected in the sylvatic, peridomestic and intradomestic area, respectively. In CSL captures yielded 108 individuals: 40.7% in the sylvatic area, 20.4% peridomestic and 38.9% intradomestic. We found no correlation between climatic variables and population abundance of T. dimidiata. Dataset obtained suggests that individuals from the sylvatic area exhibit a high rate of natural infection by T. cruzi, with monthly percentages up to 61.5% for SJBS and 50% for CSL. At the peri and intradomestic level, the reservoirs apparently play an important role in the transmission, as the seroprevalence in dogs was 61.5% y 65.4%, for SJBS y CSL, respectively. Based on these findings, it was concluded that inhabitants of both communities are at a high risk of Chagas disease infection.

  15. MECHANICAL CHARACTERISTICS OF ENDOCARP AND KERNEL OF CASHEW NUT 'CCP 76' PRIOR AND POST THERMAL TREATMENT

    OpenAIRE

    De Araujo, MC; Ferraz, ACD

    2008-01-01

    Viscoelastic characteristics of raw cashew nut shell hinder its decortication by compression. In order to facilitate the shell opening and to liberate the kernel, nuts were subjected to hydration and thermal treatment in cashew nut shell liquid (CSL) at 210 degrees C. With the objective of developing more appropriate shelling mechanisms the cashew nut 'CCP 76' was characterized by its main dimensions, mass and volume, as well as mechanical behavior of the endocarp and kernel, prior and after ...

  16. Fiber Optic Based Signal Processing

    Science.gov (United States)

    1991-12-01

    Bundle * ?* * FIR Phase Mod. Tap * * FIR Recirc. Delay L ?* IIR Non Rec. ID Latt * FIR Rec. 1D Latt * * * * IIR Mixed lD Latt IIR Non Rec. 2D Latt FIR Rec...Appl. No.: 326,657 cslFlw.- Appl. Pby Lert. vol. 43(2). p. 149.,1933. 12.2] Fik& td 21, 198 P E.-a iu -Wiliamn L S~kes Az~naAr Ezw ~unrr-obn Ngo [51) ImL

  17. Prosody development of Chinese spontaneous speech of American English speakers learning Chinese as a second language%汉语作为第二语言的自然口语韵律的发展

    Institute of Scientific and Technical Information of China (English)

    陈默

    2013-01-01

    Prosodic production capability is important for second language control and speech organization.This study investigates the prosodic patterns of intermediate and advantage level American English Speaking,Chinese as a second language (CSL) learners,with comparisons with native Chinese speakers.This research studies the correlation of prosodic features in spontaneous speech production.The results indicate that the prosodic patterns of American English speaking CSL learners differ from native Chinese speakers with some similar prosodic patterns.The prosodic patterns of American English speaking CSL learners vary at different stages of their language acquisition.The universality and automatic speech production characteristics constrain the development of CSL oral prosody.%口语韵律的产出能力是第二语言学习者言语控制和组织能力发展的主要表现.该文对中、高级汉语水平的美国留学生汉语口语产出的韵律模式进行了研究,并将汉语母语者的发音语料作为基线数据进行比较.研究结果表明:美国留学生口语产出的韵律模式跟汉语母语者的既有相似之处,又存在着一定的差异;而且在不同的语言习得阶段,美国留学生口语产出的韵律模式也不同.言语产出的普遍性和第二语言言语产出的自动化程度共同制约着汉语作为第二语言的口语韵律的发展.

  18. Antivenom Cross-Neutralization of the Venoms of Hydrophis schistosus and Hydrophis curtus, Two Common Sea Snakes in Malaysian Waters

    OpenAIRE

    Choo Hock Tan; Nget Hong Tan; Kae Yi Tan; Kok Onn Kwong

    2015-01-01

    Sea snake envenomation is a serious occupational hazard in tropical waters. In Malaysia, the beaked sea snake (Hydrophis schistosus, formerly known as Enhydrina schistosa) and the spine-bellied sea snake (Hydrophis curtus, formerly known as Lapemis curtus or Lapemis hardwickii) are two commonly encountered species. Australian CSL sea snake antivenom is the definitive treatment for sea snake envenomation; it is unfortunately extremely costly locally and is not widely available or adequately ...

  19. Antivenom Cross-Neutralization of the Venoms of Hydrophis schistosus and Hydrophis curtus, Two Common Sea Snakes in Malaysian Waters

    OpenAIRE

    Choo Hock Tan; Nget Hong Tan; Kae Yi Tan; Kok Onn Kwong

    2015-01-01

    Sea snake envenomation is a serious occupational hazard in tropical waters. In Malaysia, the beaked sea snake (Hydrophis schistosus, formerly known as Enhydrina schistosa) and the spine-bellied sea snake (Hydrophis curtus, formerly known as Lapemis curtus or Lapemis hardwickii) are two commonly encountered species. Australian CSL sea snake antivenom is the definitive treatment for sea snake envenomation; it is unfortunately extremely costly locally and is not widely available or adequately ...

  20. Property ∏σ and tensor products of operator algebras

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    In this paper, we introduce Property ∏σ of operator algebras and prove that nest subalgebras and the finite-width CSL subalgebras of arbitrary von Neumann algebras have Property ∏σ.Finally, we show that the tensor product formula alg ML1-(×)algNL2 = algM-(×)N(L1 (×) L2) holds for any two finite-width CSLs L1 and L2 in arbitrary von Neumann algebras M and N, respectively.

  1. Delta-Complete Reachability Analysis (Part 1)

    Science.gov (United States)

    2013-12-01

    Lecture Notes in Computer Science , pages...and G. Rozenberg, editors, REX Workshop, volume 600 of Lecture Notes in Computer Science , pages 45–73. Springer, 1991. [4] M. Fränzle. Analysis of...hybrid systems: An ounce of realism can save an infinity of states. In J. Flum and M. Rodrı́guez-Artalejo, editors, CSL, volume 1683 of Lecture Notes in Computer Science ,

  2. Impact of an endorectal coil for 1H-magnetic resonance spectroscopy of the prostate at 3.0T in comparison to 1.5T: Do we need an endorectal coil?

    Science.gov (United States)

    Hoffner, Maximilian K M; Huebner, Frank; Scholtz, Jan Erik; Zangos, Stephan; Schulz, Boris; Luboldt, Wolfgang; Vogl, Thomas J; Bodelle, Boris

    2016-08-01

    To evaluate the influence of endorectal coil (ERC) regarding spectral quality and diagnostic suitability and diagnostic performance in 3.0T 1H-magnetic resonance spectroscopy imaging (MRSI) compared to 1.5T MRSI. The study was approved by the Institutional Review Board. MRSI of the prostate was performed on 19 patients at 1.5T with ERC (protocol 1), at 3.0T with a disabled ERC (protocol 2) and at 3.0T with ERC (protocol 3). Age, weight, body size, body-mass-index, prostate volume, time between measurements, diagnostic suitability of spectra, histopathological results after biopsy of cancer suspect lesions (CSL), sensitivity and specificity were evaluated. Signal-to-noise ratio (SNR) was calculated and compared using semiparametrical multiple Conover-comparisons. Correlations between SNR and prostate volume and BMI were indicated using Pearson correlation coefficient. Distribution of SNR was evaluated for prostate quadrants. Diagnostic suitable spectra were achieved in 76 % (protocol 1, 100% in CSL), 32 % (protocol 2, 59% in CSL) and 50 % (protocol 3, 80% in CSL) of the voxels. SNR was significantly higher in protocol 3 compared to protocol 2 and 1 (93,729 vs. 27,836 vs. 32,897, p<0.0001) with significant difference between protocol 2 and 1 (p<0.023). Highest SNR was achieved in the dorsal prostate (protocols 1 and 3; p<0.0001). Sensitivity at 3.0T was higher with use of ERC. Specificity was highest at 1.5T with ERC. The ERC improves the diagnostic suitability and the SNR in MRSI at 3.0T. Less voxels at 3.0T with disabled ERC are suitable for diagnosis compared to 1.5T with ERC. MRSI at 3.0T with ERC shows the highest SNR. SNR in dorsal quadrants of the prostate was higher using ERC. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  3. Atomic Layering, Intermixing and Switching Mechanism in Ge-Sb-Te based Chalcogenide Superlattices

    OpenAIRE

    Xiaoming Yu; John Robertson

    2016-01-01

    GeSbTe-based chalcogenide superlattice (CSLs) phase-change memories consist of GeSbTe layer blocks separated by van der Waals bonding gaps. Recent high resolution electron microscopy found two types of disorder in CSLs, a chemical disorder within individual layers, and SbTe bilayer stacking faults connecting one block to an adjacent block which allows individual block heights to vary. The disorder requires a generalization of the previous switching models developed for CSL systems. Density fu...

  4. Atomic Layering, Intermixing and Switching Mechanism in Ge-Sb-Te based Chalcogenide Superlattices.

    OpenAIRE

    Yu, X.; Robertson, J

    2016-01-01

    GeSbTe-based chalcogenide superlattice (CSLs) phase-change memories consist of GeSbTe layer blocks separated by van der Waals bonding gaps. Recent high resolution electron microscopy found two types of disorder in CSLs, a chemical disorder within individual layers, and SbTe bilayer stacking faults connecting one block to an adjacent block which allows individual block heights to vary. The disorder requires a generalization of the previous switching models developed for CSL systems. Density fu...

  5. COMPLETELY BOUNDED COHOMOLOGY OF NON-SELFADJOINT OPERATOR ALGEBRAS

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The authors prove that all n-th completely bounded cohomology groups of a nest algebra T(N) acting on a separable Hilbert space are trivial when the coefficients lie in any ultraweakly closed T(N)-bimodule containing the nest algebra. They also prove that Hcnb(A, M) (≌) Hcnb(A, A) for all n ≥ 1 and a CSL algebra A with an ultraweakly closed A-bimodule M containing A.

  6. Developmental signaling pathways regulating mammary stem cells and contributing to the etiology of triple-negative breast cancer

    OpenAIRE

    Rangel,Maria Cristina; Bertolette, Daniel; Castro, Nadia P.; Klauzinska, Malgorzata; Cuttitta, Frank; Salomon, David S

    2016-01-01

    Cancer has been considered as temporal and spatial aberrations of normal development in tissues. Similarities between mammary embryonic development and cell transformation suggest that the underlying processes required for mammary gland development are also those perturbed during various stages of mammary tumorigenesis and breast cancer (BC) development. The master regulators of embryonic development Cripto-1, Notch/CSL, and Wnt/β-catenin play key roles in modulating mammary gland morphogenes...

  7. Comparing the fermentation performance of Escherichia coli KO11, Saccharomyces cerevisiae 424A(LNH-ST and Zymomonas mobilis AX101 for cellulosic ethanol production

    Directory of Open Access Journals (Sweden)

    Dale Bruce E

    2010-05-01

    Full Text Available Abstract Background Fermentations using Escherichia coli KO11, Saccharomyces cerevisiae 424A(LNH-ST, and Zymomonas mobilis AX101 are compared side-by-side on corn steep liquor (CSL media and the water extract and enzymatic hydrolysate from ammonia fiber expansion (AFEX-pretreated corn stover. Results The three ethanologens are able produce ethanol from a CSL-supplemented co-fermentation at a metabolic yield, final concentration and rate greater than 0.42 g/g consumed sugars, 40 g/L and 0.7 g/L/h (0-48 h, respectively. Xylose-only fermentation of the tested ethanologenic bacteria are five to eight times faster than 424A(LNH-ST in the CSL fermentation. All tested strains grow and co-ferment sugars at 15% w/v solids loading equivalent of ammonia fiber explosion (AFEX-pretreated corn stover water extract. However, both KO11 and 424A(LNH-ST exhibit higher growth robustness than AX101. In 18% w/w solids loading lignocellulosic hydrolysate from AFEX pretreatment, complete glucose fermentations can be achieved at a rate greater than 0.77 g/L/h. In contrast to results from fermentation in CSL, S. cerevisiae 424A(LNH-ST consumed xylose at the greatest extent and rate in the hydrolysate compared to the bacteria tested. Conclusions Our results confirm that glucose fermentations among the tested strains are effective even at high solids loading (18% by weight. However, xylose consumption in the lignocellulosic hydrolysate is the major bottleneck affecting overall yield, titer or rate of the process. In comparison, Saccharomyces cerevisiae 424A(LNH-ST is the most relevant strains for industrial production for its ability to ferment both glucose and xylose from undetoxified and unsupplemented hydrolysate from AFEX-pretreated corn stover at high yield.

  8. Weight lifting

    Energy Technology Data Exchange (ETDEWEB)

    Drysdale, G.S.; Murphy, J.C. [CSL Asia (Singapore)

    2006-03-15

    The paper considers the advantages of using self-unloaders (SULs) for transporting and handling major dry bulk commodities such as coal. Advantages include speed, discharge flexiblity, efficiency, ability to blend coals on the vessel, cost effectiveness, and noise and dust control features. A case study outlines how CSL helped design a coal receiving terminal for the AES Corp. in Puerto Rico which was an SUL terminal with a state-of-the-art dust suppression system. 2 photos.

  9. Modelling the Caspian Sea and its catchment area using a coupled regional atmosphere-ocean model (RegCM4-ROMS: model design and preliminary results

    Directory of Open Access Journals (Sweden)

    U. U. Turuncoglu

    2013-03-01

    Full Text Available We describe the development of a coupled regional atmosphere-ocean model (RegCM4-ROMS and its implementation over the Caspian Sea basin. The coupled model is run for the period 1999–2008 (after a spin up of 4 yr and it is compared to corresponding stand alone model simulations and a simulation in which a distributed 1d lake model is run for the Caspian Sea. All model versions show a good performance in reproducing the climatology of the Caspian Sea basin, with relatively minor differences across them. The coupled ROMS produces realistic, although somewhat overestimated, Caspian Sea Surface Temperature (SST, with a considerable improvement compared to the use of the simpler coupled lake model. Simulated near surface salinity and sea currents are also realistic, although the upwelling over the eastern coastal regions is underestimated. The sea ice extent over the shallow northern shelf of the Caspian Sea and its seasonal evolution are well reproduced, however, a significant negative bias in sea-ice fraction exists due to the relatively poor representation of the bathymetry. ROMS also calculates the Caspian Sea Level (CSL, showing that for the present experiment excessive evaporation over the lake area leads to a drift in estimated CSL. Despite this problem, which requires further analysis due to many uncertainties in the estimation of CSL, overall the coupled RegCM4-ROMS system shows encouraging results in reproducing both the climatology of the region and the basic characteristics of the Caspian Sea.

  10. Economic Optimized Medium for Tensio-Active Agent Production by Candida sphaerica UCP0995 and Application in the Removal of Hydrophobic Contaminant from Sand

    Directory of Open Access Journals (Sweden)

    Galba M. Campos-Takaki

    2011-04-01

    Full Text Available Statistical experimental designs and response surface methodology were employed to optimize the concentrations of agroindustrial residues as soybean oil (SORR from refinery, and corn steep liquor (CSL from corn industry, for tensio-active agent produced by Candida sphaerica UCP 0995. Three 22 full factorial design were applied sequentially to investigate the effects of the concentrations and interactions of soybean oil refinery residue and corn steep liquor on the surface tension of free-cell culture broth for 144 h. Two 22 central composite designs and response surface methodology were adopted to derive a statistical model to measure the effect of SORR and CSL on the surface tension of the free-cell culture broth for 144 h. The regression equation obtained from the experimental data using a central composite design was solved, and by analyzing the response surface contour plots, the optimal concentrations of the constituents of the medium were determined: 8.63% v/v (≈9% v/v of SORR and 8.80% v/v (≈9% v/v CSL. The minimum surface tension predicted and experimentally confirmed was 25.25 mN/m. The new biosurfactant, denominated Lunasan, recovered 95% of motor oil adsorbed in a sand sample, thus showing great potential for use in bioremediation processes, especially in the petroleum industry.

  11. Comparative Shear-Bond Strength of Six Dental Self-Adhesive Resin Cements to Zirconia

    Directory of Open Access Journals (Sweden)

    Si-Eun Lee

    2015-06-01

    Full Text Available This study compared shear bond strength (SBS of six self-adhesive resin cements (SARC and one resin-modified glass ionomer cement (RMGIC to zirconia before and after thermocycling. The cylinder shape (Φ 2.35 mm × 3 mm of six SARCs (G-CEM LinkAce (GLA, Maxcem Elite (MAX, Clearfil SA Luting (CSL, PermaCem 2.0 (PM2, Rely-X U200 (RXU, Smartcem 2 (SC2 were bonded to the top surface of the zirconia specimens with light-curing. RMGIC (Fujicem (FJC was bonded to the specimens with self-curing. The shear bond strength of all cemented specimens was measured with universal testing machine. Half of the specimens were thermocycled 5000 times before shear bonding strength testing. Fractured surfaces were examined with a field-emission SEM (10,000× and analyzed by energy dispersive x-ray analysis. MAX, PM2, SC2 group without thermocycling and GLA, MAX, PM2 group with thermocycling showed adhesive failure, but GLA, CSL, RXU, FJC group without thermocycling and SLC, RXU, SC2, FJC group with thermocycling indicated cohesive failure. Within the limitation of this study, All of SARCs except MAX demonstrated higher bond strength than that of RMGIC regardless of thermocycling. Also, SARC containing MDP monomers (CSL retained better bonds than other cements.

  12. Evaluation of Saccharomyces cerevisiae Y5 for ethanol production from enzymatic hydrolysate of non-detoxified steam-exploded corn stover.

    Science.gov (United States)

    Li, Yun; Gao, Kai; Tian, Shen; Zhang, Sijin; Yang, Xiushan

    2011-11-01

    Saccharomyces cerevisiae Y5 was used to produce ethanol from enzymatic hydrolysate of non-detoxified steam-exploded corn stover, with and without a nitrogen source, and decreasing inoculum size. The results indicated that the ethanol concentration of 44.55 g/L, corresponding to 94.5% of the theoretical yield was obtained after 24 h, with an inoculum size of 10% (v/v) and nitrogen source (corn steep liquor, CSL) of 40 mL/L. With the same inoculum size, and without CSL, the ethanol concentration was 43.21 g/L, corresponding to 91.7% of the theoretical value after 60 h. With a decreased inoculum size of 5% (v/v), and without CSL, the ethanol concentration was 40.00 g/L, corresponding to 85.8% of the theoretical value after 72 h. The strain offers the potential to improve the economy of cellulosic ethanol production by simplifying the production process and reducing the costs associated with the process such as water, capital equipment and nutrient supplementation.

  13. Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes

    Energy Technology Data Exchange (ETDEWEB)

    Arnett, Kelly L.; Hass, Matthew; McArthur, Debbie G.; Ilagan, Ma Xenia G.; Aster, Jon C.; Kopan, Raphael; Blacklow, Stephen C. (WU); (BWH); (DFCI)

    2010-11-12

    Ligand-induced proteolysis of Notch produces an intracellular effector domain that transduces essential signals by regulating the transcription of target genes. This function relies on the formation of transcriptional activation complexes that include intracellular Notch, a Mastermind co-activator and the transcription factor CSL bound to cognate DNA. These complexes form higher-order assemblies on paired, head-to-head CSL recognition sites. Here we report the X-ray structure of a dimeric human Notch1 transcription complex loaded on the paired site from the human HES1 promoter. The small interface between the Notch ankyrin domains could accommodate DNA bending and untwisting to allow a range of spacer lengths between the two sites. Cooperative dimerization occurred on the human and mouse Hes5 promoters at a sequence that diverged from the CSL-binding consensus at one of the sites. These studies reveal how promoter organizational features control cooperativity and, thus, the responsiveness of different promoters to Notch signaling.

  14. Numerical evidence for a chiral spin liquid in the XXZ antiferromagnetic Heisenberg model on the kagome lattice at m =2/3 magnetization

    Science.gov (United States)

    Kumar, Krishna; Changlani, Hitesh J.; Clark, Bryan K.; Fradkin, Eduardo

    2016-10-01

    We perform an exact-diagonalization study of the spin-1/2 XXZ Heisenberg antiferromagnet on the kagome lattice at finite magnetization m =2/3 with an emphasis on the X Y point (Jz=0 ) and in the presence of a small chiral term. Recent analytic work by Kumar et al. [K. Kumar, K. Sun, and E. Fradkin, Phys. Rev. B 90, 174409 (2014), 10.1103/PhysRevB.90.174409] on the same model, using a newly developed flux attachment transformation, predicts a plateau at this value of the magnetization described by a chiral spin liquid (CSL) with a spin Hall conductance of σx y=1/2 . Such a state is topological in nature, has a ground-state degeneracy, and exhibits fractional excitations. We analyze the degeneracy structure in the low-energy manifold, identify the candidate topological states, and use them to compute the modular matrices and Chern numbers, all of which strongly agree with expected theoretical behavior for the σx y=1/2 CSL. In the limit of zero chirality, we find on most (not all) clusters that the topological invariants are still those of a CSL.

  15. Effectiveness of compacted soil liner as a gas barrier layer in the landfill final cover system.

    Science.gov (United States)

    Moon, Seheum; Nam, Kyoungphile; Kim, Jae Young; Hwan, Shim Kyu; Chung, Moonkyung

    2008-01-01

    A compacted soil liner (CSL) has been widely used as a single barrier layer or a part of composite barrier layer in the landfill final cover system to prevent water infiltration into solid wastes for its acceptable hydraulic permeability. This study was conducted to test whether the CSL was also effective in prohibiting landfill gas emissions. For this purpose, three different compaction methods (i.e., reduced, standard, and modified Proctor methods) were used to prepare the soil specimens, with nitrogen as gas, and with water and heptane as liquid permeants. Measured gas permeability ranged from 2.03 x 10(-10) to 4.96 x 10(-9) cm(2), which was a magnitude of two or three orders greater than hydraulic permeability (9.60 x 10(-13) to 1.05 x 10(-11) cm(2)). The difference between gas and hydraulic permeabilities can be explained by gas slippage, which makes gas more permeable, and by soil-water interaction, which impedes water flow and then makes water less permeable. This explanation was also supported by the result that a liquid permeability measured with heptane as a non-polar liquid was similar to the intrinsic gas permeability. The data demonstrate that hydraulic requirement for the CSL is not enough to control the gas emissions from a landfill.

  16. Antioxidant and Anti-Inflammatory Effects of Chaenomeles sinensis Leaf Extracts on LPS-Stimulated RAW 264.7 Cells.

    Science.gov (United States)

    Han, Young-Ki; Kim, Yon-Suk; Natarajan, Sithranga Boopathy; Kim, Won-Suk; Hwang, Jin-Woo; Jeon, Nam-Joo; Jeong, Jae-Hyun; Moon, Sang-Ho; Jeon, Byong-Tae; Park, Pyo-Jam

    2016-03-28

    The fruit of Chaenomeles sinensis has been traditionally used in ethnomedicine for the treatment of various human ailments, including pneumonia, bronchitis, and so on, but the pharmacological applications of the leaf part of the plant have not been studied. In this study, we evaluated the various radical scavenging activities and anti-inflammatory effects of different Chaenomeles sinensis leaf (CSL) extracts. The water extract showed a higher antioxidant and radical scavenging activities. However the ethanolic extracts showed higher NO scavenging activity than water extract, therefore the ethanolic extract of CSL was examined for anti-inflammatory effects on lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. The 70% ethanol extract of CSL (CSLE) has higher anti-inflammatory activity and significantly inhibited the production of nitric oxide (NO), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). In addition, CSLE suppressed LPS-stimulated inducible nitric oxide synthase (iNOS) and NO production, IL-1β and phospho-STAT1 expression. In this study, we investigated the effect of CSLE on the production of inflammatory mediators through the inhibition of the TRIF-dependent pathways. Furthermore, we evaluated the role of CSLE on LPS-induced expression of pro-inflammatory cytokines, such as TNF-α, IL-1β and IL-6. Our results suggest that CSLE attenuates the LPS-stimulated inflammatory responses in macrophages through regulating the key inflammatory mechanisms, providing scientific support for its traditional uses in treating various inflammatory diseases.

  17. Economic optimized medium for tensio-active agent production by Candida sphaerica UCP0995 and application in the removal of hydrophobic contaminant from sand.

    Science.gov (United States)

    Luna, Juliana M; Rufino, Raquel D; Albuquerque, Clarissa D C; Sarubbo, Leonie A; Campos-Takaki, Galba M

    2011-01-01

    Statistical experimental designs and response surface methodology were employed to optimize the concentrations of agroindustrial residues as soybean oil (SORR) from refinery, and corn steep liquor (CSL) from corn industry, for tensio-active agent produced by Candida sphaerica UCP 0995. Three 2(2) full factorial design were applied sequentially to investigate the effects of the concentrations and interactions of soybean oil refinery residue and corn steep liquor on the surface tension of free-cell culture broth for 144 h. Two 2(2) central composite designs and response surface methodology were adopted to derive a statistical model to measure the effect of SORR and CSL on the surface tension of the free-cell culture broth for 144 h. The regression equation obtained from the experimental data using a central composite design was solved, and by analyzing the response surface contour plots, the optimal concentrations of the constituents of the medium were determined: 8.63% v/v (≅9% v/v) of SORR and 8.80% v/v (≅9% v/v) CSL. The minimum surface tension predicted and experimentally confirmed was 25.25 mN/m. The new biosurfactant, denominated Lunasan, recovered 95% of motor oil adsorbed in a sand sample, thus showing great potential for use in bioremediation processes, especially in the petroleum industry.

  18. Thermomechanical processing optimization for 304 austenitic stainless steel using artificial neural network and genetic algorithm

    Science.gov (United States)

    Feng, Wen; Yang, Sen

    2016-12-01

    Thermomechanical processing has an important effect on the grain boundary character distribution. To obtain the optimal thermomechanical processing parameters is the key of grain boundary engineering. In this study, genetic algorithm (GA) based on artificial neural network model was proposed to optimize the thermomechanical processing parameters. In this model, a back-propagation neural network (BPNN) was established to map the relationship between thermomechanical processing parameters and the fraction of low-Σ CSL boundaries, and GA integrated with BPNN (BPNN/GA) was applied to optimize the thermomechanical processing parameters. The validation of the optimal thermomechanical processing parameters was verified by an experiment. Moreover, the microstructures and the intergranular corrosion resistance of the base material (BM) and the materials produced by the optimal thermomechanical processing parameters (termed as the GBEM) were studied. Compared to the BM specimen, the fraction of low-Σ CSL boundaries was increased from 56.8 to 77.9% and the random boundary network was interrupted by the low-Σ CSL boundaries, and the intergranular corrosion resistance was improved in the GBEM specimen. The results indicated that the BPNN/GA model was an effective and reliable means for the thermomechanical processing parameters optimization, which resulted in improving the intergranular corrosion resistance in 304 austenitic stainless steel.

  19. A Cross Structured Light Sensor and Stripe Segmentation Method for Visual Tracking of a Wall Climbing Robot.

    Science.gov (United States)

    Zhang, Liguo; Sun, Jianguo; Yin, Guisheng; Zhao, Jing; Han, Qilong

    2015-06-11

    In non-destructive testing (NDT) of metal welds, weld line tracking is usually performed outdoors, where the structured light sources are always disturbed by various noises, such as sunlight, shadows, and reflections from the weld line surface. In this paper, we design a cross structured light (CSL) to detect the weld line and propose a robust laser stripe segmentation algorithm to overcome the noises in structured light images. An adaptive monochromatic space is applied to preprocess the image with ambient noises. In the monochromatic image, the laser stripe obtained is recovered as a multichannel signal by minimum entropy deconvolution. Lastly, the stripe centre points are extracted from the image. In experiments, the CSL sensor and the proposed algorithm are applied to guide a wall climbing robot inspecting the weld line of a wind power tower. The experimental results show that the CSL sensor can capture the 3D information of the welds with high accuracy, and the proposed algorithm contributes to the weld line inspection and the robot navigation.

  20. Low-cost production of 6G-fructofuranosidase with high value-added astaxanthin by Xanthophyllomyces dendrorhous.

    Science.gov (United States)

    Ning, Yawei; Li, Qiang; Chen, Feng; Yang, Na; Jin, Zhengyu; Xu, Xueming

    2012-01-01

    The effects of medium composition and culture conditions on the production of (6)G-fructofuranosidase with value-added astaxanthin were investigated to reduce the capital cost of neo-fructooligosaccharides (neo-FOS) production by Xanthophyllomyces dendrorhous. The sucrose and corn steep liquor (CSL) were found to be the optimal carbon source and nitrogen source, respectively. CSL and initial pH were selected as the critical factors using Plackett-Burman design. Maximum (6)G-fructofuranosidase 242.57 U/mL with 5.23 mg/L value-added astaxanthin was obtained at CSL 52.5 mL/L and pH 7.89 by central composite design. Neo-FOS yield could reach 238.12 g/L under the optimized medium conditions. Cost analysis suggested 66.3% of substrate cost was reduced compared with that before optimization. These results demonstrated that the optimized medium and culture conditions could significantly enhance the production of (6)G-fructofuranosidase with value-added astaxanthin and remarkably decrease the substrate cost, which opened up possibilities to produce neo-FOS industrially.

  1. Modeling the Caspian Sea and its catchment area using a coupled regional atmosphere-ocean model (RegCM-ROMS: model design and preliminary results

    Directory of Open Access Journals (Sweden)

    U. U. Turuncoglu

    2012-11-01

    Full Text Available We describe the development of a coupled regional atmosphere-ocean model (RegCM-ROMS and its implementation over the Caspian Sea basin. The coupled model is run for the period 1999–2008 (after a spin up of 4 yr and it is compared to corresponding stand alone model simulations and a simulation in which a distributed 1d lake model is run for the Caspian Sea. All model versions show a good performance in reproducing the climatology of the Caspian Sea basin, with relatively minor differences across them. The coupled ROMS produces realistic, although somewhat overestimated, lake surface temperatures (LSTs, with a considerable improvement compared to the use of the simpler coupled lake model. Simulated near surface salinity and sea currents are also realistic, although the upwelling over the eastern coastal regions is underestimated. The distribution of sea ice over the shallow northern shelf of the Caspian Sea and its seasonal evolution are well reproduced. ROMS also calculates the Caspian Sea Level (CSL, showing that for the present experiment excessive evaporation over the lake area leads to a drift in estimated CSL. Despite this problem which requires further analysis due to many uncertainties in the estimation of CSL, overall the coupled RegCM-ROMS system shows encouraging results in reproducing both the climatology of the region and the basic characteristics of the Caspian Sea.

  2. Evidence for an association between nonsyndromic cleft lip with or without cleft palate and a gene located on the long arm of chromosome 4

    Energy Technology Data Exchange (ETDEWEB)

    Mitchell, L.E.; Healey, S.C.; Chenevix-Trench, G. [St. Louis Univ. Health Sciences Center, MO (United States)]|[Queensland Institute of Medical Research, Brisbane (Australia)

    1995-11-01

    Recent studies suggest that the familial aggregation of nonsyndromic cleft lip with or without cleft palate (CL{+-}P) is likely to be attributable to the effects of several susceptibility loci, acting in a multiplicative fashion. Two potential CL{+-}P susceptibility loci (CSL), transforming growth factor alpha (TGFA) and retinoic acid receptor (RARA), have been identified through association studies. In addition, recent evidence of linkage between CL{+-}P and two markers (D4S175 and D4S192) in the region 4q25-4q31.3 raised the possibility that a CSL, with a larger effect than either TGFA or RARA, may reside within this region of the human genome. The present analyses were undertaken to determine whether D4S175 or D4S192 is significantly associated with CL{+-}P in a sample of unrelated patients that have previously provided evidence of associations between CL{+-}P and both TGFA and RARA. The results of these analyses provide further, tentative, evidence for the presence of a CSL locus on the long arm of chromosome 4 and help to refine the location of this locus in the region of D4S175 and D4S192. 28 refs., 4 tabs.

  3. Regulation of Notch-mediated transcription by a bovine herpesvirus 1 encoded protein (ORF2) that is expressed in latently infected sensory neurons.

    Science.gov (United States)

    Liu, Yilin; Jones, Clinton

    2016-08-01

    Bovine herpesvirus 1 (BoHV-1) is an Alphaherpesvirinae subfamily member that establishes life-long latency in sensory neurons. The latency-related RNA (LR-RNA) is abundantly expressed during latency. An LR mutant virus containing stop codons at the amino-terminus of open reading frame (ORF)2 does not reactivate from latency and replicates less efficiently in tonsils and trigeminal ganglia. ORF2 inhibits apoptosis, interacts with Notch family members, and interferes with Notch-dependent transcription suggesting ORF2 expression enhances survival of infected neurons. The Notch signaling pathway is crucial for neuronal differentiation and survival suggesting that interactions between ORF2 and Notch family members regulate certain aspects of latency. Consequently, for this study, we compared whether ORF2 interfered with the four mammalian Notch family members. ORF2 consistently interfered with Notch1-3-mediated transactivation of three cellular promoters. Conversely, Notch4-mediated transcription was not consistently inhibited by ORF2. Electrophoretic shift mobility assays using four copies of a consensus-DNA binding site for Notch/CSL (core binding factor (CBF)-1, Suppressor of Hairless, Lag-2) as a probe revealed ORF2 interfered with Notch1 and 3 interactions with a CSL family member bound to DNA. Additional studies demonstrated ORF2 enhances neurite sprouting in mouse neuroblastoma cells that express Notch1-3, but not Notch4. Collectively, these studies indicate that ORF2 inhibits Notch-mediated transcription and signaling by interfering with Notch interacting with CSL bound to DNA.

  4. 24 weeks of Pilates-aerobic and educative training to improve body fat mass in elderly Serbian women

    Directory of Open Access Journals (Sweden)

    Rutjes AWS

    2014-04-01

    Full Text Available Anne WS Rutjes,1 Marcello Di Nisio2,31Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland; 2Department of Medical, Oral, and Biotechnological Sciences, University G D'Annunzio of Chieti-Pescara, Chieti, Italy; 3Department of Vascular Medicine, Academic Medical Center, Amsterdam, the NetherlandsWe read with interest the article by Ruiz-Montero et al, in which the authors used a before-and-after study design to examine changes in body composition (fat mass and lean body mass related to an aerobic-Pilates program in elderly Serbian women.1 The authors concluded that "a combined program of aerobic and Pilates, carried out under the supervision of an instructor, at least twice a week, produces health benefits in functionally independent women over the age of 60". This conclusion is overly optimistic and not supported by the evidence provided. View original paper by Ruiz-Montero and colleagues.

  5. Molecular dynamics simulation of steady shear flows of liquid crystalline molecules; Ekishosei bunshi no teijo sendan nagare ni taisuru bunshi dorikigaku simulation

    Energy Technology Data Exchange (ETDEWEB)

    Mori, N.; Morimoto, J.; Nakamura, K. [Osaka University, Osaka (Japan). Faculty of Engineering

    1996-04-25

    Numerical simulations of the steady shear flows of a nematic phase are performed using nonequilibrium molecular dynamics. The SLLOD algorithm is developed for application to the steady shear flows of ellipsoids of revolution that interact via the Gay-Berne potential. The system composed of particles interacting via the Gay-Berne potential forms various phases including a nematic one. In the initial stage of simple shear flow of the nematic phase, the order parameter significantly decreases as the director rotates rapidly. The director, however, is inclined at a nearly constant angle regardless of shear rate in the steady state. Rheological properties, such as shear viscosity and normal stress differences, are examined. 18 refs., 9 figs.

  6. Perturbative Quantum Field Theory in the String-Inspired Formalism

    CERN Document Server

    Schubert, C

    2001-01-01

    We review the status and present range of applications of the ``string-inspired'' approach to perturbative quantum field theory. This formalism offers the possibility of computing effective actions and S-matrix elements in a way which is similar in spirit to string perturbation theory, and bypasses much of the apparatus of standard second-quantized field theory. Its development was initiated by Bern and Kosower, originally with the aim of simplifying the calculation of scattering amplitudes in quantum chromodynamics and quantum gravity. We give a short account of the original derivation of the Bern-Kosower rules from string theory. Strassler's alternative approach in terms of first-quantized particle path integrals is then used to generalize the formalism to more general field theories, and, in the abelian case, also to higher loop orders. A considerable number of sample calculations are presented in detail, with an emphasis on quantum electrodynamics.

  7. Particle Accelerators and Detectors for medical Diagnostics and Therapy

    CERN Document Server

    Braccini, Saverio

    2016-01-01

    This Habilitationsschrift (Habilitation thesis) is focused on my research activities on medical applications of particle physics and was written in 2013 to obtain the Venia Docendi (Habilitation) in experimental physics at the University of Bern. It is based on selected publications, which represented at that time my major scientific contributions as an experimental physicist to the field of particle accelerators and detectors applied to medical diagnostics and therapy. The thesis is structured in two parts. In Part I, Chapter 1 presents an introduction to accelerators and detectors applied to medicine, with particular focus on cancer hadrontherapy and on the production of radioactive isotopes. In Chapter 2, my publications on medical particle accelerators are introduced and put into their perspective. In particular, high frequency linear accelerators for hadrontherapy are discussed together with the new Bern cyclotron laboratory. Chapter 3 is dedicated to particle detectors with particular emphasis on three ...

  8. Balancing contemporary fairness and historical justice. A 'quasi-equitable' proposal for GHG mitigations

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Zili; Sirianni, Philip [State University of New York at Binghamton (United States); Colgate University (United States)

    2010-09-15

    In this paper, we analyze the impasse, caused by polarizing positions of the United States and China - in international negotiations on carbon mitigation. By incorporating the Bern carbon cycle module into the RICE model developed by Nordhaus and Yang (1996), we set up a framework for tracking regional contributions to carbon concentration and to global climate change. Our proposal, labeled the 'color preservation' principle, uses regional contribution share to global carbon concentration as the criterion for international cooperation. Through simulations in RICE model with Bern module (RICE-B), we examine the rationales of the arguments made by the United States and China. We conclude that both countries' standpoints are severely flawed. To facilitate the global cooperation on carbon mitigations, major concessions are needed from the two top carbon emitters. (author)

  9. Computer simulation of confined liquid crystal dynamics

    CERN Document Server

    Webster, R E

    2001-01-01

    are performed of the formation of structures in confined smectic systems where layer tilt is induced by an imposed surface pretilt. Results show that bookshelf, chevron and tilled layer structures are observable in a confined Gay-Berne system. The formation and stability of the chevron structure are shown to be influenced by surface slip. Results are presented from a series of simulations undertaken to determine whether dynamic processes observed in device-scale liquid crystal cells confined between aligning substrates can be simulated in a molecular system using parallel molecular dynamics of the Gay-Berne model. In a nematic cell, on removal of an aligning field, initial near-surface director relaxation can induce flow, termed 'backflow' in the liquid. This, in turn, can cause director rotation, termed 'orientational kickback', in the centre of the cell. Simulations are performed of the relaxation in nematic systems confined between substrates with a common alignment on removal of an aligning field. Results...

  10. Particle physics in your pocket!

    CERN Document Server

    Anaïs Schaeffer

    2012-01-01

    CERN physicists, take out your smartphones! Two new particle physics applications for Android phones have been developed by a physicist from the University of Bern: “Particle Properties” and “Particle Physics Booklet 2010”.   “When I'm on shift, I enjoy looking at the online event displays,” says Igor Kreslo from the Laboratory for High Energy Physics at the University of Bern, the physicist who has developed the two particle physics applications for Android. “Sometimes very beautiful events appear, with many different particles. I like to discuss these displays with my students, just to develop their ability to identify particles. We try to find out which particle is which and how it might decay… I think that's the best way to teach students the phenomenology of particle physics.” When scientists study particle physics, they require some vital information, such as the decay branching ...

  11. The role of peer assisted learning to improve the effectivity of clinical skill laboratory learning in dental education

    Directory of Open Access Journals (Sweden)

    Agus Ardinansyah

    2016-06-01

    Full Text Available Nowadays, the clinical skill learning in dental education has begun in pre-clinic, known as Clinical Skill Laboratory (CSL which needs human resources, many and expensive tools and manikins, and enough times for practise. One of the method used in CSL in dental education is PeerAssisted Learning (PAL defined as “the development of knowledge and skill through active help and support among status equals or match companions”. This paper aims is to explain the role of PAL method to improve the effectivity of CSL learning in dental education in preclinical stage. Reviewing on the relevant literatures regarding peer assisted learning on the implementation of the clinical skill laboratory in dental education. The effectivity of CSL learning needs close supervision and individual feedback, so enough tutors is important through the process. This PAL method considered to be helpfull with the increasing numbers of dental students and the limitation of staff faculty. This method is found feasible, well accepted by peer-tutors and students, and can be as effective as conventional learning method. This is also useful for peer-teacher because they more intrinsically motivated, have higher conceptual learning scores, and perceive themselves to be more actively engaged with the environment than students who learn in order to be tested.  However, there are several limitation of this method. The contact time between students and medical doctors may decrease significantlyand it does not seem to be generally qualified to transfer such complex procedures.It also needs peer-teachers training and a detailed manual. Questions concerning the cost-effectiveness and profitability of student tutor-guided technical skills training may thus arise. But one institution that implemented this method states that the majority of their tutors decided to continue their teaching activity in the skills lab and that these experienced tutors, in addition to established faculty staff

  12. Mechanical thrombectomy in acute ischemic stroke: Consensus statement by ESO-Karolinska Stroke Update 2014/2015, supported by ESO, ESMINT, ESNR and EAN

    OpenAIRE

    Wahlgren, N; Moreira, T.; Michel, P.; Steiner, T.; Jansen, O; Cognard, C; Mattle, H P; van Zwam, W.; Holmin, S.; Tatlisumak, T.; Petersson, J; Caso, V.; Hacke, W; Mazighi, M.; Arnold, M.

    2016-01-01

    The original version of this consensus statement on mechanical thrombectomy was approved at the European Stroke Organisation (ESO)-Karolinska Stroke Update conference in Stockholm, 16–18 November 2014. The statement has later, during 2015, been updated with new clinical trials data in accordance with a decision made at the conference. Revisions have been made at a face-to-face meeting during the ESO Winter School in Berne in February, through email exchanges and the final version has then bee...

  13. Book Reviews

    OpenAIRE

    Redactie KITLV

    2008-01-01

    Michael Williams; Deforesting the earth; From prehistory to global crisis (Greg Bankoff) Alexander Adelaar, Nikolaus P. Himmelmann (eds); The Austronesian languages of Asia and Madagascar (René van den Berg) Wim Ravesteijn, Jan Kop (eds); Bouwen in de archipel; Burgerlijke Openbare Werken in Nederlands-Indië en Indonesië 1800-2000 (Freek Colombijn) Susan Rodgers; Print, poetics, and politics; A Sumatran epic in the colonial Indies and New Order Indonesia (Bern...

  14. Narrative Journalism in the Age of the Internet. New Ways to Create Authenticity in Online Literary Reportages

    Directory of Open Access Journals (Sweden)

    Nora Berning

    2011-11-01

    Full Text Available Online literary reportages represent an imperative counterweight to conventional journalism that is essential both for our emotional and intellectual survival. Using Paula Delgado-Kling’s online literary reportage Child Soldiers: Homero and Mark Bowden’s multimedia text The Desert One Debacle as examples, Nora Berning explores issues of multimediality and authenticity in online narrative journalism. Berning’s case studies open up discussions, both theoretical and practical, about the future of digital media literacy.

  15. Développement méthodologique de l'application d'agents pharmacologiques renforçateurs de l'effet photoélectrique pour l'utilisation du rayonnement synchrotron en radiothérapie anticancéreuse

    OpenAIRE

    CORDE, Stéphanie

    2002-01-01

    Président: M. VALLADE, Professeur, Université Joseph Fourier, Grenoble Rapporteur: M. TERRISSOL, Professeur, Université Paul Sabatier, Toulouse Rapporteur: C. LE SECH, Professeur, Université Paris XI, Orsay Examinateur: J. LAISSUE, Professeur émérite, Université de Bern, Suisse; Anticancer therapy rests on three main principles: 1) anatomic confinement of irradiation; 2) temporal fractioning of treatment; 3) treatment of tissues that are more sensitive to radiation than surrounding healthy ti...

  16. On the calculation of effective actions by string methods

    CERN Document Server

    Schmidt, M G

    1993-01-01

    Strassler's formulation of the string-derived Bern-Kosower formalism is reconsidered with particular emphasis on effective actions and form factors. Two- and three point form factors in the nonabelian effective action are calculated and compared with those obtained in the heat kernel approach of Barvinsky, Vilkovisky et al. We discuss the Fock-Schwinger gauge and propose a manifestly covariant calculational scheme for one-loop effective actions in gauge theory.

  17. Multiloop calculations in the string-inspired formalism the single spinor-loop in QED

    CERN Document Server

    Schmidt, M G; Schmidt, M G; Schubert, C

    1996-01-01

    We use the worldline path-integral approach to the Bern-Kosower formalism for developing a new algorithm for calculation of the sum of diagrams with one spinor-loop and fixed numbers of external and internal photons. The method is based on worldline supersymmetry, and on the construction of multiloop worldline Green functions. The two-loop QED \\beta -- function is calculated as an example.

  18. Photon splitting in a strong magnetic field recalculation and comparison with previous calculations

    CERN Document Server

    Adler, Stephen Louis; Adler, Stephen L; Schubert, Christian

    1996-01-01

    We recalculate the amplitude for photon splitting in a strong magnetic field below the pair production threshold, using the worldline path integral variant of the Bern--Kosower formalism. Numerical comparison (using programs that we have made available for public access on the Internet) shows that the results of the recalculation are identical to the earlier calculations of Adler and later of Stoneham, and to the recent recalculation by Baier, Milstein, and Shaisultanov.

  19. Worldline Green functions for multiloop diagrams

    CERN Document Server

    Schmidt, M G

    1994-01-01

    We propose a multiloop generalization of the Bern-Kosower formalism, based on Strassler's approach of evaluating worldline path integrals by worldline Green functions. Those Green functions are explicitly constructed for the basic two-loop graph, and for a loop with an arbitrary number of propagator insertions. For scalar and abelian gauge theories, the resulting integral representations allow to combine whole classes of Feynman diagrams into compact expressions.

  20. Fair Share or Freeride: Burden Sharing in Post-Cold War NATO

    Science.gov (United States)

    2015-05-23

    Afghanistan. In 2012, PfP nations Austria, Morocco, Switzerland , and Ukraine all contributed larger contingents than most NATO members.92 As with...Jennifer. Going Global or Going Nowhere? NATO’s Role in Contemporary International Security. Bern, Switzerland : Peter Lang, 2008. Mihalka, Michael...Deterrent Force. Hong Kong: Concord Publications, 1992. Nurkin, Tate. “ Flagging Force? Options for the Evolution of NATO. Jane’s Intelligence Review

  1. First runs with the ORPHEUS dark matter detector

    CERN Document Server

    Czapek, G; Hauser, M; Janos, S; Loaiza, P; Moser, U; Pretzl, K; Brandt, B V D; Konter, J A; Mango, S; Ebert, T; Kainer, K U; Knoop, K M

    2002-01-01

    The ORPHEUS dark matter experiment is completed at our shallow depth laboratory in Bern (70 m.w.e.). The detector relies on measuring the magnetic flux variation produced by weakly interacting massive particles (WIMPs) as they heat 30 mu m diameter superheated superconducting tin granules (SSG) and induce superconducting-to-normal phase transitions. In an initial phase, 0.45 kg of tin granules in a segmented detector volume have been used. Preliminary results of the experiment will be reported.

  2. Cultural Resources, Studies, Eastern North Carolina Above Cape Lookout, Literature Review and Preliminary Research Design.

    Science.gov (United States)

    1986-05-01

    inhabitants and activities of New Bern in the years im- mediately following the War of 1812. Most enlightening ; usually reliable. Mobley 1981 is an...Virginia upon the development of the [- Albemarle would be highly enlightening . 2-67 1 CHAPTER 3 ARCHITECTURAL RESOURCES OF THE EASTERN NORTH CAROLINA...trends. Georgian, Federal, Greek Revival, Gothic Revival, and Italianate styles, though sometimes retarditaire in nature, predominated. Builders and

  3. Buchbesprechungen

    OpenAIRE

    1984-01-01

    Rezensionen folgender Werke: Minuchin, Fishman, H.Cb. (1983): Praxis der strukturellen Familientherapie, Strategien und Techniken. Freiburg im Breisgau. Rett, A. (1983) Mongolismus. Biologische, erzieherische und soziale Aspekte 2. , ergänzte und überarbeitete Auflage. Erschienen als Band 9 der Reihe "Arbeiten zur Theorie und Praxis der Rehabilitation in Medizin, Psychologie und Sonderpädagogik" Bern. Flackenberg, W. (1983): Die psycho-soziale Situation von Geschwistern behinderte...

  4. Particle Accelerators and Detectors for medical Diagnostics and Therapy

    OpenAIRE

    Braccini, Saverio

    2016-01-01

    This Habilitationsschrift (Habilitation thesis) is focused on my research activities on medical applications of particle physics and was written in 2013 to obtain the Venia Docendi (Habilitation) in experimental physics at the University of Bern. It is based on selected publications, which represented at that time my major scientific contributions as an experimental physicist to the field of particle accelerators and detectors applied to medical diagnostics and therapy. The thesis is structur...

  5. Biological potential of fungi associated to Prays oleae in Trás-os-Montes (Northeastern region of Portugal)

    OpenAIRE

    Oliveira,Ivo; Baptista, Paula; Lino-Neto, Teresa; Bento, Albino; PEREIRA, J. A.

    2010-01-01

    Olive groves represent an important fraction of the agricultural practices in Portugal, mainly in the region of Trás-os-Montes. Our work pretends to disclose the fungal diversity associated to one of the major olives pests, the Prays oleae Bern. Besides evaluating the extent of the presence of entomopathogenic fungi, we also intend to reveal other promising fungi with potential to be used as biological control agents. In order to achieve this goal, larvae and pupae of the three generations...

  6. Will Climate Change the Future of Homeland Security

    Science.gov (United States)

    2016-09-01

    Brookings-Bern Project on Internal Displacement, 2013), 9–18, http://www.brookings.edu/~/media/ research /files/ papers /2013/1/30-arctic-alaska-bronen...nuclear sources, and renewable energy resources (hydro, wind, biomass, geothermal , and solar power) are also used in the generation of... Research Program, 2014), 119, http://nca2014.globalchange.gov/ report/sectors/ energy . 57 According to Climate Change Impacts in the United States

  7. International Symposium on Applied Military Psychology (17th) Held at Portuguese Air Force Base Number 1, Portugal on 18-22 May 1981.

    Science.gov (United States)

    1981-07-01

    earliest studies into LPC (Least Prefirred Co- Worker) variables were done with the Belqian Army, many years ago. In his paper, Jesuinos (Portugal) looked...Joao Grade Monteiro Direegao do Servico do Pessoal Jorge Correia Jesuino 7a Repartigao Orlindo G. Pereira Ministerio da Mxrinhi Praga do Comercio, Lisbon... Luis Manuel R. Fonseca Centro de Estudos Psiotecnicos Eduardo Rodue da Clinha do Exercotp Manuel Justino Silva Av. de Berne 26-40 Joaquin Julio

  8. Unifying representation of Bézier curve and two kinds of generalized ball curves

    Institute of Scientific and Technical Information of China (English)

    ZHU Xiaolin; WANG Zhihua

    2012-01-01

    This paper presents a new basis, the WSB basis, which unifies the Bemstein basis, Wang-Ball basis and Said-Ball basis, and therefore the Bézier curve, Wang-Ball curve and Said-Ball curve are the special cases of the WSB curve based on the WSB basis In addition, the relative degree elevation formula, recursive algorithm and conversion formula between the WSB basis and the Bern- stein basis are given.

  9. For information - Geneva University: The search for the QCD phase transition / SEMINAIRE ANNULE ! ! !

    CERN Multimedia

    Université de Genève

    2005-01-01

    Ecole de physique Département de physique nucléaire et corspusculaire 24, Quai Ernest-Ansermet 1211 GENEVE 4 TéL: (022) 379 62 73 Fax: (022) 379 69 92 Wednesday 1st June 2005 PARTICLE PHYSICS SEMINAR at 17.00 hrs - Stückelberg Auditorium The search for the QCD phase transition by Prof. Sonja Kabana, Université de Berne SEMINAIRE ANNULE ! ! ! Information : http://dpnc.unige.ch/seminaire/annonce.html Organizer : A. Cervera Villanueva

  10. Long-term Outcome of Arterial Stroke in Children

    Directory of Open Access Journals (Sweden)

    J Gordon Millichap

    2015-05-01

    Full Text Available Investigators at University Children’s Hospital, Inselspital, and Universities of Bern, Geneva, Basel, and Zurich, Switzerland compared long-term outcome of children (1 month-16 years and young adults (16.1-45 years with arterial ischemic stroke (AIS using prospective data from the Swiss Neuropediatric Stroke Registry and the Adult Bernese stroke registry, between Jan 2000 and Dec 2008.

  11. ARI Basic Research Program FY 2000-2001

    Science.gov (United States)

    2000-07-01

    were tested in the United States and in Sweden . In addition to answering the multiple-choice questions, each participant completed the Bern Sex Role...collaboration with human-computer interaction research at Umea University in Sweden , have supported the causal model. The results from the Team...for the pronounced individual differences and group (e.g., children versus adults, adults versus elderly, normally developing versus ADHD ) that are

  12. The Effects of Diabetes Mellitus on the Relationship Between Myocardial Adenosine Production and Coronary Vascular Resistance

    Science.gov (United States)

    1987-03-13

    II diabetics comprise 85 - 90 % of the diabetic population, are usually obese , are not ketosis prone, and usually develop symptoms secondary to a...increases glucose transport and protein synthesis whjle inhibiting lipolysis in adipose tissue (Berne and Levy, 1983) . The hormone acts through...acids into the circulation by increasing glycogenolysis, lipolysis , and protein catabolism in liver, skeletal muscle, and fat. In diabetes, the

  13. Dichtung und Wahrheit zur Biomilch

    OpenAIRE

    2005-01-01

    Die Qualität von Biomilch sei nicht besser als diejenige von IP-Milch. Und Biotiere seien unterernährt. Mit diesen Aussagen wurde Professor Jürg Blum von der Universität Bern in den Medien zitiert. Seine Äusserungen gehen auf zwei Doktorarbeiten zurück. Das exakte Studium der Arbeit zeigt aber, dass diese Schlussfolgerungen nicht gezogen werden können.

  14. [Hanggliding accidents. Distribution of injuries and accident analysis].

    Science.gov (United States)

    Ballmer, F T; Jakob, R P

    1989-12-01

    Paragliding--a relatively new sport to Switzerland--brought 23 patients with 48 injuries (38% lower limb and 29% spinal) within a period of 8 months to the Inselspital University hospital in Berne. The aim of the study in characterizing these injuries is to formulate some guidelines towards prevention. With over 90% of accidents occurring at either take off or landing, emphasis on better training for the beginner is proposed with strict guidelines for the more experienced pilot flying in unfavourable conditions.

  15. The conceptualization and organization of the first International Neurological Congress (1931): the coming of age of neurology.

    Science.gov (United States)

    Louis, Elan D

    2010-07-01

    The first International Neurological Congress (Berne, Switzerland, 1931), attended by individuals from 42 countries, signified a global presence of world neurology; a coming of age. The aim of this study was to trace the history of that Congress, an important episode in the emergence of our discipline. The historical literature was reviewed and a detailed study conducted of the Henry Alsop Riley Papers, Columbia University. These papers contain primary source material from the Berne conference. In 1927, two neurologists, Bernard Sachs (American, 1858-1944) and Otto Marburg (Austrian, 1874-1948) met at an Austrian spa town and began to consider the creation of a meeting with a truly international character. The Americans were to play a seminal role in the organization of the Congress. In 1928, an introductory letter from Sachs went out to the international community and, in 1929, a planning meeting was held and the general principles of the Congress were established. Several earlier attempted congresses had been thwarted by World War I and European tensions would also influence the organization of the Berne Congress. Gordon Holmes (1876-1965) wrote: 'It would be certainly wiser to have the meeting in Scandinavia, Holland or Switzerland, as the only difficulty may be to get the French and Germans to mix.' Interest in the congress was immense and subsequent international congresses (London, Copenhagen, Paris, Lisbon and Brussels) became a central event in world neurology. In summary, the Berne Congress brought together individuals from several continents, thereby facilitating the exchange of ideas across entire schools. More broadly, the congress reflected a growing trend toward specialization in neurology and medicine.

  16. Aktemra - pervyy i edinstvennyy biologicheskiy preparat, demonstriruyushchiy prevoskhodstvo nad sushchestvuyushchimi standartami terapii revmatoidnogo artrita

    Directory of Open Access Journals (Sweden)

    - -

    2008-01-01

    ostro neobkhodimy novye varianty terapii RA. Uil'yam M. Berns - glava podrazdeleniya Farma kompanii «Rosh»: «Dannye poslednikh issledovaniy yavlyayutsya obnadezhivayushchey novost'yu dlya patsientov, stradayushchikh ot razrushitel'nykh effektov RA. My verim, chto Aktemra - pervyy i edinstvennyy biologicheskiy preparat, demonstriruyushchiy preimushchestvo pered sushchestvuyushchimi standartami lecheniya RA, - oblegchit sostoyanie mnogikh bol'nykh. Krome togo, Aktemra predostavlyaet bol'she shansov dlya dostizheniya ranney i prodolzhitel'noy remissii».

  17. Aktemra - pervyy i edinstvennyy biologicheskiy preparat, demonstriruyushchiy prevoskhodstvo nad sushchestvuyushchimi standartami terapii revmatoidnogo artrita

    Directory of Open Access Journals (Sweden)

    - -

    2008-09-01

    ostro neobkhodimy novye varianty terapii RA. Uil'yam M. Berns - glava podrazdeleniya Farma kompanii «Rosh»: «Dannye poslednikh issledovaniy yavlyayutsya obnadezhivayushchey novost'yu dlya patsientov, stradayushchikh ot razrushitel'nykh effektov RA. My verim, chto Aktemra - pervyy i edinstvennyy biologicheskiy preparat, demonstriruyushchiy preimushchestvo pered sushchestvuyushchimi standartami lecheniya RA, - oblegchit sostoyanie mnogikh bol'nykh. Krome togo, Aktemra predostavlyaet bol'she shansov dlya dostizheniya ranney i prodolzhitel'noy remissii».

  18. United States Foreign Policy in the Middle East After the Cold War

    Science.gov (United States)

    2006-05-31

    critics”, a more critical and pacifistic perspective is found. This category consists of authors like Noam Chomsky and Stephen Zunes. Chomsky’s “Rouge...City Lights books, 2002. Champoux, Bernard S. A National Military Strategy for the 21st Century. U.S. Army War College, 1999. Chomsky , Noam . 9-11...guard the guardians themselves? (Bern: Peter Lang AG, 1998), 309. 6Noam Chomsky , Rouge States (Cambridge: South End Press, 2000), 55. 83 BIBLIOGRAPHY

  19. Zeitschriftenübersicht und Buchbesprechungen

    OpenAIRE

    1996-01-01

    Zeitschriftenübersicht und Buchbesprechungen: Oerter, R./Montada, L. (1995): Entwicklungspsychologie. Weinheim. Büttner, Ch. (1995): Gruppenarbeit - eine psychoanalytisch pädagogische Einführung. Mainz. Harnisch, G. (1995): Was Kinderträume sagen. Freiburg. Nissen, G. (Hrsg.) (1995): Angsterkrankungen - Prävention und Therapie. Bern. Vogt, M./Winizki, E. (1995): Ambulante Gruppentherapie mit Jugendlichen. Frankfurt a.M.. Gang, M. (Hrsg.) (1995): Ausbildung und Praxisfe...

  20. Zeitschriftenübersicht und Buchbesprechungen

    OpenAIRE

    1993-01-01

    Zeitschriftenübersicht und Buchbesprechungen: de Shazer, S. (1991): Putting Difference to Work. New York. Schaffer, M. R. (1992): ... und was geschieht mit den Kindern? Bern. Ludewig, K. (1992): Systemische Therapie. Grundlagen klinischer Theorie und Praxis. Stuttgart. Eickhoff, F.-W./Loch, W. (Hrsg) (1992): Jahrbuch der Psychoanalyse - Beitrage zur Theorie und Praxis, Bd. 29. Stuttgart. Wiesse, J. (Hrsg) (1992): Chaos und Regel. Die Psychoanalyse in ihren Institutionen. G...

  1. Clausewitzian Friction and Future War Revised Edition

    Science.gov (United States)

    2004-01-01

    Hanoverian general Rudolf von Hammerstein was ordered to occupy the town of Menin in southern Belgium, Scharnhorst served as his principal staff offi...their own files. 100 ENDNOTES FOR PAGES 38–41 156 The intractability of the traveling salesman, or Steiner shortest network, problem is as fol- lows...the class of “hard” problems epitomized by the Steiner problem remains “the preeminent problem in theoretical computer science” (Marshall W. Bern and

  2. Design of Gradient Index Optical Thin Films

    Science.gov (United States)

    1996-06-12

    Editors, Proc. SPIE, 2046:179-188 (1993). 2 Arfken , G. Mathematical Methods for Physicists (Third Edition). Orlando: Academic Press, 1985. 3 Berning, P. H...plasma," in Inhomogeneous and Quasi- Inhomogeneous Optical Coatings, J. A. Dobrowolski, P. G. Verly, Editors, Proc. SPIE, 2046:179-188 (1993). 2 Arfken ...Inhomogeneous Optical Coatings, J. A. Dobrowolski, P. G. Verly, Editors, Proc. SPIE, 2046:179-188 (1993). 2 Arfken , G. Mathematical Methods for Physicists

  3. [Sketches of Swiss psychiatry in the generation after Eugen Bleuler and Sigmund Freud. With personal recollections].

    Science.gov (United States)

    Weber, Kaspar

    2009-01-01

    Focussing on the leading staff of the psychiatric universitiy clinic of Waldau/Bern, the author sketches the reception of psychoanalysis in Switzerland around 1940. It ranged from outright rejection (Ernst Grünthal) via various forms of skepticism based on superficial (Jakob Klaesi) or thorough familiarity with Freud's writings (Jakob Wyrsch, Arnold Weber) to the discipleship of an analysand of Freud (Ernst Blum).

  4. Achievements and Challenges in the Science of Space Weather

    Science.gov (United States)

    Koskinen, Hannu E. J.; Baker, Daniel N.; Balogh, André; Gombosi, Tamas; Veronig, Astrid; von Steiger, Rudolf

    2017-08-01

    In June 2016 a group of 40 space weather scientists attended the workshop on Scientific Foundations of Space Weather at the International Space Science Institute in Bern. In this lead article to the volume based on the talks and discussions during the workshop we review some of main past achievements in the field and outline some of the challenges that the science of space weather is facing today and in the future.

  5. Towards a Possible Therapy for Diabetes Complications

    Science.gov (United States)

    2011-10-01

    Johansson, B.L.; Lindstrom , P.; Juntll- Berggren, L.; Norrby, A.; Berne, C.; Arnqvist, H.J.; Bolinder, J.; Wahren, J. C-Peptide replacement therapy and...superoxide production blocks three pathways of hypergly- caemic damage. Nature, 2000, 404, 787-790. [71] Martin -Gallan, P.; Carrascosa, A.; Gussinye, M... Martin , R.; Hoeth, M.; Hofer-Warbinek, R.; Schmid, J.A. The transcription factor NF-kappa B and the regulation of vascular cell function

  6. Games people play the psychology of human relationships

    CERN Document Server

    Berne, Eric

    2010-01-01

    The bestselling Games People Play is the book that has helped millions of people understand the dynamics of relationships, by psychiatrist Eric Berne.We all play games. In every encounter with other people we are doing so. The nature of these games depends both on the situation and on who we meet.Eric Berne's classic Games People Play is the most accessible and insightful book ever written about the games we play: those patterns of behaviour that reveal hidden feelings and emotions. Wise and witty, it shows the underlying motivations behind our relationships and explores the roles that we try to play - and are forced to play.Games People Play gives you the keys to unlock the psychology of others - and yourself. You'll become more honest, more effective, and a true team player.'A brilliant, amusing, and clear catalogue of the psychological theatricals that human beings play over and over again' Kurt VonnegutEric Berne was a prominent psychiatrist and bestselling author.After inventing his groundbreaking Transa...

  7. Proteasas alcalinas de una cepa nativa de Bacillus sp Alcalofílico Proteasas alcalinas de una cepa nativa de Bacillus sp Alcalofílico

    Directory of Open Access Journals (Sweden)

    A. Sáez Vega

    2006-06-01

    Full Text Available Se evaluó el efecto de cuatro fuentes de nitrógeno sobre la actividad enzimática de proteasas alcalinas, secretadas por una cepa nativa de Bacillus sp Alcalofílico, cultivada a diferentes concentraciones de LMF (Licor de Maíz Fermentado. El crecimiento de la cepa no es afectado por los pH de inoculación de 7,0; 8,5 y 9,5; en contraste con la actividad enzimática y producción de proteína verdadera, que tuvieron sus mejores resultados a pH inicial de 8,5. A este pH se evaluaron dos fuentes de nitrógeno orgánico (extracto de levadura y peptona y dos inorgánicos (NH4Cl y NaNO3The effect of four nitrogen sources on the enzymatic activity of alkaline proteases from a wild strain of Alkalophilic Bacillus sp cultivated to different concentrations from CSL (Corn Steep Liquor. was evaluated. The growth of the strain is not affected by pH of inoculation of 7,0, 8,5 and 9,5, in contrast to the enzymatic activity and true protein production, that had their better results to initial pH of 8,5. To this initial pH of 8,5; two organic nitrogen sources (yeast extract and peptone and two inorganic ones were evaluated (NH4Cl and NaNO3. With peptone the best enzymatic activity to a relation appeared to molar C/N between 1 and 2 was found. For the studied interval of % CSL (0,5 to 2% p/v the concentration of the CSL does not affect the enzymatic activity.

  8. Molecular analysis of the notch repressor-complex in Drosophila: characterization of potential hairless binding sites on suppressor of hairless.

    Directory of Open Access Journals (Sweden)

    Patricia Kurth

    Full Text Available The Notch signalling pathway mediates cell-cell communication in a wide variety of organisms. The major components, as well as the basic mechanisms of Notch signal transduction, are remarkably well conserved amongst vertebrates and invertebrates. Notch signalling results in transcriptional activation of Notch target genes, which is mediated by an activator complex composed of the DNA binding protein CSL, the intracellular domain of the Notch receptor, and the transcriptional coactivator Mastermind. In the absence of active signalling, CSL represses transcription from Notch target genes by the recruitment of corepressors. The Notch activator complex is extremely well conserved and has been studied in great detail. However, Notch repressor complexes are far less understood. In Drosophila melanogaster, the CSL protein is termed Suppressor of Hairless [Su(H]. Su(H functions as a transcriptional repressor by binding Hairless, the major antagonist of Notch signalling in Drosophila, which in turn recruits two general corepressors--Groucho and C-terminal binding protein CtBP. Recently, we determined that the C-terminal domain (CTD of Su(H binds Hairless and identified a single site in Hairless, which is essential for contacting Su(H. Here we present additional biochemical and in vivo studies aimed at mapping the residues in Su(H that contact Hairless. Focusing on surface exposed residues in the CTD, we identified two sites that affect Hairless binding in biochemical assays. Mutation of these sites neither affects binding to DNA nor to Notch. Subsequently, these Su(H mutants were found to function normally in cellular and in vivo assays using transgenic flies. However, these experiments rely on Su(H overexpression, which does not allow for detection of quantitative or subtle differences in activity. We discuss the implications of our results.

  9. Grain boundary engineering for intergranular corrosion resistant austenitic stainless steel%抗晶间腐蚀奥氏体不锈钢的晶界工程

    Institute of Scientific and Technical Information of China (English)

    粉川博之

    2005-01-01

    Sensitization by chromium depletion due to chromium carbide precipitation at grain boundaries in austenitic stainless steels can not be prevented perfectly only by previous conventional techniques, such as reduction of carbon content, stabilization-treatment, local solution-heat-treatment, etc. Recent studies on grain boundary structure have revealed that the sensitization depends strongly on grain boundary character and atomic structure, and that low energy grain boundaries such as coincidence-site-lattice (CSL) boundaries have strong resistance to intergranular corrosion. The concept of 'grain boundary design and control' has been developed as grain boundary engineering (GBE). GBEed materials are characterized by high frequencies of CSL boundaries which are resistant to intergranular deterioration of materials, such as intergranular corrosion. A thermomechanical treatment was tried to improve the resistance to the sensitization by GBE. A type 304 austenitic stainless steel was cold-rolled and solution-heat-treated, and then sensitization-heat-treated. The grain boundary character distribution was examined by orientation imaging microscopy (OIM). The intergranular corrosion resistance was evaluated by electrochemical potentiokinetic reactivation (EPR) and ferric sulfate-sulfuric acid tests. The sensitivity to intergranular corrosion was reduced by the thermomechanical treatment and indicated a minimum at a small roll-reduction. The frequency of CSL boundaries indicated a maximum at the small reduction. The ferric sulfate-sulfuric acid test showed much smaller corrosion rate in the thermomechanical-treated specimen than in the base material. A high density of annealing twins were observed in the thermomechanical-treated specimen. The results suggest that the therrmomechanical treatment can introduce low energy segments in the grain boundary network by annealing twins and can arrest the percolation of intergranular corrosion from the surface. The effects of carbon

  10. Conservation of the Notch antagonist Hairless in arthropods: functional analysis of the crustacean Daphnia pulex Hairless gene.

    Science.gov (United States)

    Zehender, Ariella; Bayer, Melanie; Bauer, Milena; Zeis, Bettina; Preiss, Anette; Maier, Dieter

    2017-08-31

    The Notch signaling pathway is highly conserved in all animal metazoa: upon Notch receptor activation, transcription of Notch target genes is turned on by an activator complex that centers on the transcription factor CSL. In the absence of signal, CSL assembles transcriptional repression complexes that display remarkable evolutionary diversity. The major antagonist of Notch signaling in insects named Hairless was originally identified in Drosophila melanogaster. It binds to the Drosophila CSL homologue Suppressor of Hairless [Su(H)] and recruits the two general co-repressors, Groucho and C-terminal binding protein. Whereas the majority of Notch signaling components is conserved between insects and vertebrates, Hairless is found only in insects. Here, we present the analysis of the Hairless gene from Daphnia pulex and, hence, for the first time from a crustacean. Daphnia and Drosophila Hairless protein sequences are highly diverged. Known functional domains, however, the Su(H), Groucho and the C-terminal binding protein interactions domains, are well conserved. Moreover, direct binding of the Daphnia Hairless protein and the respective Drosophila interaction partners was detected, demonstrating the conservation at the molecular level. In addition, interaction between Daphnia Hairless and Drosophila Su(H) was demonstrated in vivo, as co-overexpression of the respective genes during Drosophila development resulted in the expected downregulation of Notch activity in the fly. Structural models show that the Hairless-Su(H) repressor complexes from Daphnia and Drosophila are almost indistinguishable from one another. Amino acid residues in direct contact within the Hairless-Su(H) complex are at absolutely identical positions in the two homologues.

  11. 微波复热速冻馒头保水剂及其对质构的影响%Water-Retention Agent for Microwave Reheating of Quick-Frozen Steamed Breads and Its Effect on Texture

    Institute of Scientific and Technical Information of China (English)

    范会平; 潘治利; 陈军; 王娜; 艾志录; 李嘉; 骆玫

    2012-01-01

    A water-retention agent for improving the quality of quick-frozen steamed breads after microwave reheating was prepared from several improvers such as sodium alginate, gellan gum and calcium stearoyl lactylate (CSL). The optimized water-retention agent was composed of 0.37% sodium alginate, 0.15% gellan gum and 0.21% CSL as determined using response surface methodology. The observed weight loss rate of quick-frozen steamed breads with the addition of the optimized water-retention agent after microwave reheating was 6.02%, which was close to the predicted value of 6.01%. In conclusion, the optimal water-retention agent was reliable.%以速冻馒头为研究对象,以海藻酸钠、结冷胶、硬脂酰乳酸钙(CSL)等几种改良剂为原料,研制了一种速冻馒头保水剂的配方,以提高馒头微波复热后的品质。响应面优化试验结果表明:速冻馒头保水剂的最佳配方为海藻酸钠0.37%、结冷胶0.15%、CSL0.21%。验证实验表明,在此条件下速冻馒头微波复热后质量损失率为6.02%,接近预测值6.01%,说明该配方可靠。

  12. The effect of 2% niacinamide on facial sebum production.

    Science.gov (United States)

    Draelos, Zoe Diana; Matsubara, Akira; Smiles, Kenneth

    2006-06-01

    The presence of sebum on the face is responsible for both facial shine and the formation of comedonal and inflammatory acne lesions. Sebum control is a goal of many OTC skin care products; however, most currently available products function by absorbing sebum from the face rather than modulating its production. To demonstrate the effect of topical 2% niacinamide on sebum excretion rates and casual sebum production in Oriental and Caucasian populations. Separate clinical trials were conducted in both Japan and the USA to evaluate the effect of topical 2% niacinamide in different ethnic groups. A total of 100 Japanese subjects were enrolled in a double-blind, placebo-controlled comparison between two independent balanced groups. Fifty subjects applied the 2% niacinamide moisturizer to the face for 4 weeks and 50 subjects used a placebo moisturizer for 4 weeks, with sebum excretion rate (SER) measurements taken at baseline, week 2, and week 4. In addition, 30 Caucasian subjects were enrolled in a randomized split-face study for 6 weeks with SER and casual sebum levels (CSL) measured at baseline, week 3, and week 6. The results of the Japanese study demonstrated that the SER of the two groups was not significantly different at baseline, but the 2% niacinamide treated group demonstrated significantly lowered SER after 2 and 4 weeks of application. The results were somewhat different in the Caucasian study. After 6 weeks of treatment, the CSL was significantly reduced, but the SER was not significantly reduced. Topical 2% niacinamide may be effective in lowering the SER in Japanese individuals and CSL in Caucasian individuals.

  13. Sentinel-2 diffuser on-ground calibration

    Science.gov (United States)

    Mazy, E.; Camus, F.; Chorvalli, V.; Domken, I.; Laborie, A.; Marcotte, S.; Stockman, Y.

    2013-10-01

    The Sentinel-2 multi-spectral instrument (MSI) will provide Earth imagery in the frame of the Global Monitoring for Environment and Security (GMES) initiative which is a joint undertaking of the European Commission and the Agency. MSI instrument, under Astrium SAS responsibility, is a push-broom spectro imager in 13 spectral channels in VNIR and SWIR. The instrument radiometric calibration is based on in-flight calibration with sunlight through a quasi Lambertian diffuser. The diffuser covers the full pupil and the full field of view of the instrument. The on-ground calibration of the diffuser BRDF is mandatory to fulfil the in-flight performances. The diffuser is a 779 x 278 mm2 rectangular flat area in Zenith-A material. It is mounted on a motorised door in front of the instrument optical system entrance. The diffuser manufacturing and calibration is under the Centre Spatial of Liege (CSL) responsibility. The CSL has designed and built a completely remote controlled BRDF test bench able to handle large diffusers in their mount. As the diffuser is calibrated directly in its mount with respect to a reference cube, the error budget is significantly improved. The BRDF calibration is performed directly in MSI instrument spectral bands by using dedicated band-pass filters (VNIR and SWIR up to 2200 nm). Absolute accuracy is better than 0.5% in VNIR spectral bands and 1% in SWIR spectral bands. Performances were cross checked with other laboratories. The first MSI diffuser for flight model was calibrated mid 2013 on CSL BRDF measurement bench. The calibration of the diffuser consists mainly in thermal vacuum cycles, BRDF uniformity characterisation and BRDF angular characterisation. The total amount of measurement for the first flight model diffuser corresponds to more than 17500 BRDF acquisitions. Performance results are discussed in comparison with requirements.

  14. Mercury in ground water, septage, leach-field effluent, and soils in residential areas, New Jersey coastal plain

    Science.gov (United States)

    Barringer, J.L.; Szabo, Z.; Schneider, D.; Atkinson, W.D.; Gallagher, R.A.

    2006-01-01

    Water samples were collected from domestic wells at an unsewered residential area in Gloucester County, New Jersey where mercury (Hg) concentrations in well water were known to exceed the USEPA maximum contaminant level (MCL) of 2000 ng/L. This residential area (the CSL site) is representative of more than 70 such areas in southern New Jersey where about 600 domestic wells, sampled previously by State and county agencies, yielded water containing Hg at concentrations that exceed the MCL. Recent studies indicate that background concentrations of Hg in water from this unconfined sand and gravel aquifer system are sampling was conducted at the CSL site in order to better understand sources of Hg and potential Hg transport mechanisms in the areas with Hg-contaminated ground water. At the CSL site, concentrations of Hg were substantially lower (although still exceeding the MCL in some cases) in filtered water samples than in the unfiltered water samples collected previously from the same wells. Surfactants and elevated concentrations of sodium, chloride, nitrate, ammonium, and phosphate in water from domestic and observation wells indicated septic-system effects on water quality; detections of sulfide indicated localized reducing conditions. Hg concentrations in septage and leach-field effluent sampled at several other households in the region were low relative to the contaminant-level Hg concentrations in water from domestic wells. Relations of Hg concentrations in leach-field effluent to iron concentrations indicate that reductive dissolution of iron hydroxides in soils may release Hg to the percolating effluent. ?? 2005 Elsevier B.V. All rights reserved.

  15. Structure and function of the archaeal exosome.

    Science.gov (United States)

    Evguenieva-Hackenberg, Elena; Hou, Linlin; Glaeser, Stefanie; Klug, Gabriele

    2014-01-01

    The RNA-degrading exosome in archaea is structurally very similar to the nine-subunit core of the essential eukaryotic exosome and to bacterial polynucleotide phosphorylase (PNPase). In contrast to the eukaryotic exosome, PNPase and the archaeal exosome exhibit metal ion-dependent, phosphorolytic activities and synthesize heteropolymeric RNA tails in addition to the exoribonucleolytic RNA degradation in 3' → 5' direction. The archaeal nine-subunit exosome consists of four orthologs of eukaryotic exosomal subunits: the RNase PH-domain-containing subunits Rrp41 and Rrp42 form a hexameric ring with three active sites, whereas the S1-domain-containing subunits Rrp4 and Csl4 form an RNA-binding trimeric cap on the top of the ring. In vivo, this cap contains Rrp4 and Csl4 in variable amounts. Rrp4 confers poly(A) specificity to the exosome, whereas Csl4 is involved in the interaction with the archaea-specific subunit of the complex, the homolog of the bacterial primase DnaG. The archaeal DnaG is a highly conserved protein and its gene is present in all sequenced archaeal genomes, although the exosome was lost in halophilic archaea and some methanogens. In exosome-containing archaea, DnaG is tightly associated with the exosome. It functions as an additional RNA-binding subunit with poly(A) specificity in the reconstituted exosome of Sulfolobus solfataricus and enhances the degradation of adenine-rich transcripts in vitro. Not only the RNA-binding cap but also the hexameric Rrp41-Rrp42 ring alone shows substrate selectivity and prefers purines over pyrimidines. This implies a coevolution of the exosome and its RNA substrates resulting in 3'-ends with different affinities to the exosome.

  16. Penicillin production by wild isolates of Penicillium chrysogenum in Pakistan.

    Science.gov (United States)

    Sajjad-Ur-Rahman; Rasool, Muhammad Hidayat; Rafi, Muhammad

    2012-04-01

    The present study was aimed at exploring the native wild isolates of Penicillium chrysogenum series in terms of their penicillin production potential. Apart from the standard medium, the efforts were made to utilize suitable agro-industrial wastes for the maximum yield of penicillin. Two series of P. chrysogenum were isolated from local sources and named as P. chrysogenum series UAF R1 and P. chrysogenum series UAF R2. The native series were found to possess better penicillin production potential than the already reported series of P. chrysogenum. However, P. chrysogenum series UAF R1 was found to be the best candidate for high yield of penicillin starting at 100 hour as compared to P. chrysogenum series UAF R2 which produced the highest yield of penicillin at 150 hours for a shorter period of time. Addition of Corn Steep Liquor (CSL) to the fermentation medium resulted in the production of 1.20g/L penicillin by P. chrysogenum series UAF R1 and P. chrysogenum series UAF R2. The fermentation medium in which Sugar Cane Bagasse (SCB) was replaced with CSL resulted in the highest yield of penicillin (1.92g/L) by both native series of P. chrysogenum. The penicillin production was increased by 62.5% in medium with SCB as compared to that with CSL. The penicillin yield of medium containing lactose and phenyl acetate was higher than that of control medium. Overall results revealed that P. chrysogenum series UAF R1 and P. chrysogenum series UAF R2 may be recommended for better yield of natural penicillin and this efficiency may be further enhanced by utilizing SCB as substrate in the growth medium.

  17. Penicillin production by wild isolates of Penicillium chrysogenum in Pakistan

    Directory of Open Access Journals (Sweden)

    Sajjad-Ur Rahman

    2012-06-01

    Full Text Available The present study was aimed at exploring the native wild isolates of Penicillium chrysogenum series in terms of their penicillin production potential. Apart from the standard medium, the efforts were made to utilize suitable agro-industrial wastes for the maximum yield of penicillin. Two series of P. chrysogenum were isolated from local sources and named as P. chrysogenum series UAF R1 and P. chrysogenum series UAF R2. The native series were found to possess better penicillin production potential than the already reported series of P. chrysogenum. However, P. chrysogenum series UAF R1 was found to be the best candidate for high yield of penicillin starting at 100 hour as compared to P. chrysogenum series UAF R2 which produced the highest yield of penicillin at 150 hours for a shorter period of time. Addition of Corn Steep Liquor (CSL to the fermentation medium resulted in the production of 1.20g/L penicillin by P. chrysogenum series UAF R1 and P. chrysogenum series UAF R2. The fermentation medium in which Sugar Cane Bagasse (SCB was replaced with CSL resulted in the highest yield of penicillin (1.92g/L by both native series of P. chrysogenum. The penicillin production was increased by 62.5% in medium with SCB as compared to that with CSL. The penicillin yield of medium containing lactose and phenyl acetate was higher than that of control medium. Overall results revealed that P. chrysogenum series UAF R1 and P. chrysogenum series UAF R2 may be recommended for better yield of natural penicillin and this efficiency may be further enhanced by utilizing SCB as substrate in the growth medium.

  18. Biomimetic fiber assembled gradient hydrogel to engineer glycosaminoglycan enriched and mineralized cartilage: An in vitro study.

    Science.gov (United States)

    Mohan, Neethu; Wilson, Jijo; Joseph, Dexy; Vaikkath, Dhanesh; Nair, Prabha D

    2015-12-01

    The study investigated the potential of electrospun fiber assembled hydrogel, with physical gradients of chondroitin sulfate (CS) and sol-gel-derived bioactive glass (BG), to engineer hyaline and mineralized cartilage in a single 3D system. Electrospun poly(caprolactone) (PCL) fibers incorporated with 0.1% w/w of CS (CSL) and 0.5% w/w of CS (CSH), 2.4% w/w of BG (BGL) and 12.5% w/w of BG (BGH) were fabricated. The CS showed a sustained release up to 3 days from CSL and 14 days from CSH fibers. Chondrocytes secreted hyaline like matrix with higher sulfated glycosaminoglycans (sGAG), collagen type II and aggrecan on CSL and CSH fibers. Mineralization was observed on BGL and BGH fibers when incubated in simulated body fluid for 14 days. Chondrocytes cultured on these fibers secreted a mineralized matrix that consisted of sGAG, hypertrophic proteins, collagen type X, and osteocalcin. The CS and BG incorporated PCL fiber mats were assembled in an agarose-gelatin hydrogel to generate a 3D hybrid scaffold. The signals in the fibers diffused and generated continuous opposing gradients of CS (chondrogenic signal) and BG (mineralization) in the hydrogel. The chondrocytes were encapsulated in hybrid scaffolds; live dead assay at 48 h showed viable cells. Cells maintained their phenotype and secreted specific extracellular matrix (ECM) in response to signals within the hydrogel. Continuous opposing gradients of sGAG enriched and mineralized ECM were observed surrounding each cell clusters on gradient hydrogel after 14 days of culture in response to the physical gradients of raw materials CS and BG. A construct with gradient mineralization might accelerate integration to subchondral bone during in vivo regeneration.

  19. Noise and Sonic Boom Impact Technology. BOOMAP2 Computer Program for Sonic Boom Research. Volume 3. Program Maintenance Manual

    Science.gov (United States)

    1988-08-01

    CGRNO/CO )**2 CSGM2aCOSGAM*2 AO2AO.CGFACT*CSlNMU2*CSGM2.( 1. .5*CSGM2)COSMUJ2) Al 2A -CGFACT𔃼 .SI NGAM*COSGAM*S INMU *COSMU A3=A3+CGFACTW 5*(CSGM2...DEL rAO=A IRSPO CSOO=CO*S INMU 00 25 K=1,3 PKO(K)=PKOtK)/RENORM XKSO(K)=CSQD*PKO( K) XKTO(K)wXKDOT(K) -XKSO(K) 25 CONTINUE xsO=xsO+UO YSO=YSO+vO

  20. Annealing twins in a multifunctional beta Ti–Nb–Ta–Zr–O alloy

    Indian Academy of Sciences (India)

    W Y Guo; J Sun

    2011-12-01

    The grain boundary character distribution and annealing twins in a multifunctional -type Ti–23Nb–0.7Ta–2Zr–O alloy having a stable bcc phase structure are investigated by electron backscattering diffraction (EBSD). The results show that the coincident site lattice (CSL) boundaries, including 3 and 11 twin boundaries mainly form at the early stage of recrystallization. {112}$\\langle$111$\\rangle$ and {332} $\\langle$113$\\rangle$ annealing twins are observed to occur in the completely recrystallized Ti–23Nb–0.7Ta–2Zr–O alloy.

  1. Immunoglobulin G for patients with necrotising soft tissue infection (INSTINCT)

    DEFF Research Database (Denmark)

    Madsen, Martin B; Hjortrup, Peter B; Hansen, Marco B

    2017-01-01

    PURPOSE: The aim of the INSTINCT trial was to assess the effect of intravenous polyspecific immunoglobulin G (IVIG) compared with placebo on self-reported physical function in intensive care unit (ICU) patients with necrotising soft tissue infection (NSTI). METHODS: We randomised 100 patients...... with NSTI 1:1 to masked infusion of 25 g of IVIG (Privigen, CSL Behring) or an equal volume of 0.9% saline once daily for the first 3 days of ICU admission. The primary outcome was the physical component summary (PCS) score of the 36-item short form health survey (SF-36) 6 months after randomisation...

  2. The Hybrid Threat: Crime, Terrorism and Insurgency in Mexico. Proceedings of the Joint Policy and Research Forum

    Science.gov (United States)

    2011-12-01

    Foreword Frank J. Cilluffo and Bert B. Tussing THE HYBRID THREAT of crime, terrorism and insurgency is presently understudied as a matter of policy...brave men and women in Mexico – to include the media , local police, local mayors, business leaders – all of whom now stand on the edge. A Joint CSL...unnamed television media inquiry having to do with the situation on the border, by saying: “I’m sorry we can’t take you out there....We’re not allowed

  3. Daddy’s Car: Artificial Intelligence as a Creative Tool for Copyright

    Directory of Open Access Journals (Sweden)

    Jaime Alberto Díaz Limón

    2016-12-01

    Full Text Available This year on September 19th, Sony CSL, a software developer company, announced to the world, the creation of the first musical work whose ownership belongs to Artificial Intelligence. This paper analyzes the legal consequences of such a statement, and it’s conceptual and legal limits within the Copyright Universe (with fundament on International Treaties; in order to assess whether we are in presence of new legal-authorial figure that invite us to think over the subjects of protection in our laws or whether the applicable normativity may resolve these hypotheses in favor Artificial Intelligence, instead of juridical persons.

  4. A systematic overview of the first pasteurised VWF/FVIII medicinal product, Haemate P/ Humate -P: history and clinical performance

    DEFF Research Database (Denmark)

    Berntorp, E.; Archey, W.; Auerswald, G.

    2008-01-01

    , plasma-derived VWF/FVIII medicinal product, which was first licensed in Germany in 1981 for the treatment of HA-associated bleeding. It has since then come to be accepted as the gold standard for both the treatment and prophylaxis of bleeding in VWD, especially in cases where desmopressin [1-deamino-8-D...... to have a VWF multimer profile remarkably close to that of normal plasma. This bibliographic review presents previously unpublished clinical data of Haemate P, based upon internal clinical study reports of the proprietor, CSL Behring, in addition to data already presented in other publications. The data...

  5. Grain growth of cast-multicrystalline silicon grown from small randomly oriented seed crystal

    Science.gov (United States)

    Prakash, Ronit R.; Sekiguchi, Takashi; Jiptner, Karolin; Miyamura, Yoshiji; Chen, Jun; Harada, Hirofumi; Kakimoto, Koichi

    2014-09-01

    Multicrystalline silicon was grown from seeds with small grains of random orientation and the growth mechanism was studied with respect to grain size, shape, boundary character and orientation. The average grain size perpendicular to growth direction increased steadily initially, became constant and then increased steadily again. Grain size parallel to growth direction increased rapidly with growth due to grain elongation in the growth direction. Grain shape with respect to growth direction changed from spherical to columnar with growth. Initially non-CSL grain boundary fraction was very high but decreased with growth as the Σ3 grain boundary fraction increased. A simple model was proposed to explain the results.

  6. Organizational Behavior.

    Science.gov (United States)

    1981-08-03

    5s CSL SIN 102-P4144401SE[CURItY? CLASSIFICATION 09 TWOS PAkGX10fen DRol 90. 005i. La’ fA SECURITV CLASIFICATIOh ofit T t S 6 eWhai Daa am- uso ...that the following influence an employee’s perceptions of task charac- tertistics, frequently in interaction with the objective characteris- tics of...systema- tic relationships to organizational design, it is no: to be considered as the primary determinant of variations in design and that size has

  7. A novel cysteine desulfurase influencing organosulfur compounds in Lentinula edodes

    OpenAIRE

    Ying Liu; Xiao-Yu Lei; Lian-Fu Chen; Yin-Bing Bian; Hong Yang; Ibrahim, Salam A.; Wen Huang

    2015-01-01

    Organosulfur compounds are the basis for the unique aroma of Lentinula edodes, and cysteine sulfoxide lyase (C-S lyase) is the key enzyme in this trait. The enzyme from Alliium sativum has been crystallized and well-characterized; however, there have been no reports of the characterization of fungi C-S lyase at the molecular level. We identified a L. edodes C-S lyase (Lecsl), cloned a gene of Csl encoded Lecsl and then combined modeling, simulations, and experiments to understand the molecula...

  8. Near-grain-boundary characterization by atomic force microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Pramanick, A.K., E-mail: pramanick@nmlindia.org [MST Division, National Metallurgical Laboratory, Jamshedpur 831007 (India); Sinha, A. [MST Division, National Metallurgical Laboratory, Jamshedpur 831007 (India); Sastry, G.V.S. [Centre of Advanced Study, Department of Metallurgical Engineering, Institute of Technology, Banaras Hindu University, Varanasi 221005 (India); Ghosh, R.N. [MST Division, National Metallurgical Laboratory, Jamshedpur 831007 (India)

    2009-05-15

    Characterization of near-grain boundary is carried out by atomic force microscopy (AFM). It has been observed to be the most suitable technique owing to its capability to investigate the surface at high resolution. Commercial purity-grade nickel processed under different conditions, viz., (i) cold-rolled and annealed and (ii) thermally etched condition without cold rolling, is considered in the present study. AFM crystallographic data match well with the standard data. Hence, it establishes two grain-boundary relations viz., plane matching and coincidence site lattice (CSL {Sigma}=9) relation for the two different sample conditions.

  9. Use of a C1 Inhibitor Concentrate in Adults ≥65 Years of Age with Hereditary Angioedema

    DEFF Research Database (Denmark)

    Bygum, Anette; Martinez-Saguer, Inmaculada; Bas, Murat;

    2016-01-01

    BACKGROUND: Treatment of hereditary angioedema (HAE) in 'older adults' (those aged ≥65 years) has not been well studied. The international Berinert Patient Registry collected data on the use of intravenous plasma-derived, pasteurized, nanofiltered C1-inhibitor concentrate (pnfC1-INH; Berinert......(®)/CSL Behring) in patients of any age, including many older adults. METHODS: This observational registry, conducted from 2010 to 2014 at 30 US and seven European sites, gathered prospective (post-enrollment) and retrospective (pre-enrollment) usage and adverse event (AE) data on subjects treated with pnfC1-INH...... doses were lower than those reported for 252 'younger adults' (those aged

  10. A telescope with microstrip gas chambers for the detection of charged products in heavy-ion reactions

    Energy Technology Data Exchange (ETDEWEB)

    Gramegna, F. [Istituto Nazionale di Fisica Nucleare, Legnaro (Italy). Lab. Nazionali di Legnaro; Abbondanno, U. [Ist. Nazionale di Fisica Nucleare, Sezione di Trieste and Dipt. di Fisica dell`Univ. (Italy); Andreano, A. [Ist. Nazionale di Fisica Nucleare, Sezione di Milano (Italy); Bassini, R. [Ist. Nazionale di Fisica Nucleare, Sezione di Milano (Italy); Bonutti, F. [Ist. Nazionale di Fisica Nucleare, Sezione di Trieste and Dipt. di Fisica dell`Univ. (Italy); Bruno, M. [Ist. Nazionale di Fisica Nucleare, Sezione di Bologna and Dipt. di Fisica dell`Univ. (Italy); Casini, G. [Ist. Nazionale di Fisica Nucleare, Firenze (Italy); D`Agostino, M. [Ist. Nazionale di Fisica Nucleare, Sezione di Bologna and Dipt. di Fisica dell`Univ. (Italy); Manzin, G. [Istituto Nazionale di Fisica Nucleare, Legnaro (Italy). Lab. Nazionali di Legnaro; Margagliotti, G.V. [Ist. Nazionale di Fisica Nucleare, Sezione di Trieste and Dipt. di Fisica dell`Univ. (Italy); Mastinu, P.F. [Ist. Nazionale di Fisica Nucleare, Sezione di Bologna (Italy)]|[Dipt. di Fisica dell`Univ., Padova (Italy); Milazzo, P.M. [Ist. Nazionale di Fisica Nucleare, Sezione di Trieste and Dipt. di Fisica dell`Univ. (Italy); Moroni, A. [Ist. Nazionale di Fisica Nucleare, Sezione di Milano (Italy); Squarcini, M. [Ist. Nazionale di Fisica Nucleare, Firenze (Italy); Tonetto, F. [Istituto Nazionale di Fisica Nucleare, Legnaro (Italy). Lab. Nazionali di Legnaro; Vannini, G. [Ist. Nazionale di Fisica Nucleare, Sezione di Trieste and Dipt. di Fisica dell`Univ. (Italy); Vannucci, L. [Istituto Nazionale di Fisica Nucleare, Legnaro (Italy). Lab. Nazionali di Legnaro

    1997-04-21

    Prototypes of a {Delta}E-E telescope, designed to detect and identify with low-energy threshold both light charged particles and heavy fragments, are described. They are based on a gas drift chamber which conveys primary ionization electrons on gas microstrip devices where multiplication occurs and the energy loss signals are generated. Silicon detectors or Csl(Tl) crystals operate as residual energy detectors. The prototypes were tested both with a source and heavy ion beams. Performances, mainly related to energy resolution, charge identification and angle resolution, are reported. (orig.).

  11. β-1,3 : 1,4-Glucan Synthase Activity in Rice Seedlings under Water

    Science.gov (United States)

    Kimpara, Tomoya; Aohara, Tsutomu; Soga, Kouichi; Wakabayashi, Kazuyuki; Hoson, Takayuki; Tsumuraya, Yoichi; Kotake, Toshihisa

    2008-01-01

    Background and Aims The metabolism of β-1,3 : 1,4-glucan regulates the mechanical properties of cell walls, and thereby changes the elongation growth of Poaceae plants. A previous study has shown that elongation growth of rice coleoptiles under water is enhanced by increased activity of β-1,3 : 1,4-glucan hydrolases; however, the involvement of β-1,3 : 1,4-glucan synthase activity in elongation growth under water has not yet been clarified. Methods The β-1,3 : 1,4-glucan synthase activity in a microsomal fraction prepared from rice seedlings grown under water was compared with that from control seedlings grown in air. The change under water in the relative expression level of CslF6, a major isoform of the β-1,3 : 1,4-glucan synthase genes, was examined by quantitative reverse-transcriptase PCR. Key Results The level of β-1,3 : 1,4-glucan synthase activity in submerged seedlings decreased to less than 40 % of that of the control seedlings and was accompanied by a significant reduction in the amount of β-1,3 : 1,4-glucan in the cell walls. Under water, the expression of CslF6 was reduced to less than 20 % of the unsubmerged control. Bubble aeration partially restored both β-1,3 : 1,4-glucan synthase activity and the expression of CslF6 under water, correlating with suppression of the submergence-induced elongation growth of coleoptiles. Conclusions Submergence down-regulates the expression of the CslF6 gene, leading to a decreased level of β-1,3 : 1,4-glucan synthase activity. Together with the increased activity of β-1,3 : 1,4-glucan hydrolases, the decreased activity of β-1,3 : 1,4-glucan synthase contributes to the decrease in the amount of β-1,3 : 1,4-glucan in the cell walls under water. The suppression of β-1,3 : 1,4-glucan synthesis under water may be mainly due to oxygen depletion. PMID:18487614

  12. The Effects of Thermal Stratification on Clustering Properties of Canopy Turbulence

    Science.gov (United States)

    Cava, D.; Katul, G. G.

    2009-03-01

    The intermittent structure of turbulence within the canopy sublayer (CSL) is sensitive to the presence of foliage and to the atmospheric stability regime. How much of this intermittency originates from amplitude variability or clustering properties remains a vexing research problem for CSL flows. Using a five-level set of measurements collected within a dense hardwood canopy, the clustering properties of CSL turbulence and their dependence on atmospheric stability are explored using the telegraphic approximation (TA). The binary structure of the TA removes any amplitude variability from turbulent excursions but retains their zero-crossing behaviour, and thereby isolating the role of clustering in intermittency. A relationship between the spectral exponents of the actual and the TA series is derived across a wide range of atmospheric stability regimes and for several flow variables. This relationship is shown to be consistent with a relationship derived for long-memory and monofractal processes such as fractional Brownian motion (fBm). Moreover, it is demonstrated that for the longitudinal and vertical velocity components, the vegetation does not appreciably alter fine-scale clustering but atmospheric stability does. Stable atmospheric stability conditions is characterized by more fine scale clustering when compared to other atmospheric stability regimes. For scalars, fine-scale clustering above the canopy is similar to its velocity counterpart but is significantly increased inside the canopy, especially under stable stratification. Using simplified scaling analysis, it is demonstrated that clustering is much more connected to space than to time within the CSL. When comparing intermittency for flow variables and their TA series, it is shown that for velocity, amplitude variations modulate intermittency for all stability regimes. However, amplitude variations play only a minor role in scalar intermittency. Within the crown region of the canopy, a ‘double regime

  13. The Collins Center Update. Volume 1, Issue 3, December 1999

    Science.gov (United States)

    1999-12-01

    CDN), devel oped and executed the FORO DE ESTRATEGIA NACIONAL 2005 Hon­ du ras en el Siglo XXI (FEN 2005) {Na tional Strategy Forum 2005 Hon du­ ras...that partici pated included the Air Force Space Command, Air Combat Com mand, U. S. Atlan tic Fleet, and U.S. Pa cific Fleet. The CSL team provided...quire ments and deter mine the US Army medi cal force structure and logis tics needs in the 2018 time frame. It is antici pated that the game will

  14. Danger in the reef

    DEFF Research Database (Denmark)

    Laustsen, Andreas Hougaard; Gutiérrez, José Maria; Redsted Rasmussen, Arne

    2015-01-01

    Four specimens of the olive sea snake, Aipysurus laevis, were collected off the coast of Western Australia, and the venom proteome was characterized and quantitatively estimated by RP-HPLC, SDS-PAGE, and MALDI-TOF-TOF analyses. A. laevis venom is remarkably simple and consists of phospholipases A2....../kg in mice and showed a high phospholipase A2 activity, but no proteinase activity in vitro. Preclinical assessment of neutralization and ELISA immunoprofiling showed that BioCSL Sea Snake Antivenom was effective in cross-neutralizing A. laevis venom with an ED50 of 821 μg venom per mL antivenom...

  15. “Citation Style Language” Uygulaması: APA Kaynak Gösterme Biçiminin Türkçeye Adaptasyonu=“Citation Style Language” Application: The Adaptation of APA Style to Turkish Language

    Directory of Open Access Journals (Sweden)

    Kasım Binici

    2013-10-01

    Full Text Available Bibliyografya yönetim programları, araştırma metinlerin yazımında yazarlara büyük avantajlar sağlamaktadır.Akademik çevrede EndNote, RefWorks, Zotero, Mendeley en popüler yazılımlardır. Türkçe kaynak gösterme kurallarının tanımlı olduğu biçim dosyalarının olmaması nedeniyle araştırma metni yazımında bu programlar işlevsiz kalmaktadır. Bu çalışmada, APA kaynak gösterme biçiminin Türkçeye adaptasyonu sağlanarak CSL uygulaması ile biçim dosyasında kodlar yazılmıştır. Yeni biçim dosyası Zotero ve Mendeley programlarında çalışabilirliği test edilerek kişilerin kullanımına sunulmuştur. Çalışma neticesinde oluşturulan APA-TR dosyası sayesinde Türkçe araştırma metinlerinin yazımında CSL uygulamasını tercih eden bibli- yografya yönetim yazılımların kullanımı mümkün olmuştur./Bibliography managment tools provide great advantage for researchers with writing their articles or research papers. In academic environment, EndNote, RefWorks, Zotero, Mendeley are the most popular software programms. Due to the lack of style files in which citation rules in Turkish language are described,these softwares stay functionless. In this study by providing turkish adaptation of APA citation style, new codes were written into the style file via CSL application. New style file is presented to users after testing its workability in Zotero and Mendeley programms. Thanks to APA-TR style file created as a result of the study,it is possibble to use bibliography managment tools which prefer CSL application in writing research papers Turkish language.

  16. Football Gets a Red Card

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Referees blow the whistle on their collaborations with officials in match-fixing scandals China’s trouble-plagued top soccer league,the Chinese Football Association Super League(CSL),kicked off its 2011 season on April 2 without a sponsor or a national TV deal.Days before the new season,three former league referees,who are awaiting trial,revealed the extent of match-fixing scandals that have led to the punishment of clubs,offi-cials,coaches and former players.

  17. Brewer's spent grain and corn steep liquor as alternative culture medium substrates for proteinase production by Streptomyces malaysiensis AMT-3

    Directory of Open Access Journals (Sweden)

    Rodrigo Pires do Nascimento

    2011-12-01

    Full Text Available Brewer's spent grain and corn steep liquor or yeast extract were used as the sole organic forms for proteinase production by Streptomyces malaysiensis in submerged fermentation. The influence of the C and N concentrations, as well as the incubation periods, were assessed. Eight proteolytic bands were detected through gelatin-gel-electrophoresis in the various extracts obtained from the different media and after different incubation periods, with apparent molecular masses of 20, 35, 43, 50, 70, 100, 116 and 212 kDa. The results obtained suggest an opportunity for exploring this alternative strategy for proteinases production by actinomycetes, using BSG and CSL as economically feasible substrates.

  18. Critical Science Education in a Suburban High School Chemistry Class

    Science.gov (United States)

    Ashby, Patrick

    To improve students' scientific literacy and their general perceptions of chemistry, I enacted critical chemistry education (CCE) in two "regular level" chemistry classes with a group of 25 students in a suburban, private high school as part of this study. CCE combined the efforts of critical science educators (Fusco & Calabrese Barton, 2001; Gilbert 2013) with the performance expectations of the Next Generation Science Standards (NGSS) (NGSS Lead States, 2013a) to critically transform the traditional chemistry curriculum at this setting. Essentially, CCE engages students in the critical exploration of socially situated chemistry content knowledge and requires them to demonstrate this knowledge through the practices of science. The purpose of this study was to gauge these students development of chemistry content knowledge, chemistry interest, and critical scientific literacy (CSL) as they engaged in CCE. CSL was a construct developed for this study that necessarily combined the National Research Center's (2012) definition of scientific literacy with a critical component. As such, CSL entailed demonstrating content knowledge through the practices of science as well as the ability to critically analyze the intersections between science content and socially relevant issues. A mixed methods, critical ethnographic approach framed the collection of data from open-ended questionnaires, focus group interviews, Likert surveys, pre- and post unit tests, and student artifacts. These data revealed three main findings: (1) students began to develop CSL in specific, significant ways working through the activities of CCE, (2) student participants of CCE developed a comparable level of chemistry content understanding to students who participated in a traditional chemistry curriculum, and (3) CCE developed a group of students' perceptions of interest in chemistry. In addition to being able to teach students discipline specific content knowledge, the implications of this study are

  19. The Conversion of a Peer Teaching Course in the Puncture of Peripheral Veins for Medical Students into an Interprofessional Course

    Directory of Open Access Journals (Sweden)

    Brem, Beate Gabriele

    2016-04-01

    Full Text Available Objective: There is a great interest on both a national and international level in promoting cooperation between different occupational groups within the healthcare professions through interprofessional education (IPE , , . Within this project, a peer teaching course on the puncture of peripheral veins was therefore converted from a course for medical students into an IPE learning unit. Students from different occupational groups were to learn within the context of this course, according to the definition from the World Health Organisation (WHO, with and from each other . Project description: This course constituted a small group class in the peer teaching format. The didactic principle was based on the idea that the students were to practice the respective practical skills in pairs and give each other reciprocal feedback. Together with the Department for Health at the Bern University of Applied Sciences (BUAS and the Bern Center of Higher Education of Nusing (BCHEN, the course, which was conducted by the Institute of Medical Education at the University of Bern (IME, was converted into a voluntary IPE pilot project. Students from all three institutions were represented in terms of participants as well as tutors. Results: The course was evaluated very positively by participants, peer tutors and the participating institutions. By means of an OSCE, it could be proven that the course content had been successfully imparted. On the basis of these results, it was determined that the course should be compulsory in the future for students at all three institutions. Discussion: The evaluation results show the successful conversion of the course into an IPE format within the context of the pilot project. The interactive format of the course created the prerequisite that the students from different professional groups learned with and from each other in actuality, and did not just study the same objectives at the same time as with multiprofessional learning

  20. Gluon scattering amplitudes at strong coupling

    Energy Technology Data Exchange (ETDEWEB)

    Alday, Luis F. [Institute for Theoretical Physics and Spinoza Institute, Utrecht University, 3508 TD Utrecht (Netherlands); Maldacena, Juan [School of Natural Sciences, Institute for Advanced Study, Princeton, NJ 08540 (United States)

    2007-06-15

    We describe how to compute planar gluon scattering amplitudes at strong coupling in N = 4 super Yang Mills by using the gauge/string duality. The computation boils down to finding a certain classical string configuration whose boundary conditions are determined by the gluon momenta. The results are infrared divergent. We introduce the gravity version of dimensional regularization to define finite quantities. The leading and subleading IR divergencies are characterized by two functions of the coupling that we compute at strong coupling. We compute also the full finite form for the four point amplitude and we find agreement with a recent ansatz by Bern, Dixon and Smirnov.

  1. Influência da posição das sementes no fruto do cacaueiro sôbre a germinação e desenvolvimento das mudas Influence of seed location in the cocoa fruit on germination and seedling growth

    Directory of Open Access Journals (Sweden)

    Mário Cardoso

    1963-01-01

    Full Text Available Foram plantadas separadamente, para comparação, amostras de sementes oriundas da ponta, do centro e da base de frutos de cacaueiro. Não foram notadas diferenças, quer na germinação das sementes, quer no desenvolvimento das mudas, em duas variedades estudadas.Seed samples from the top, center, and bottom of the cocoa fruit (Theobroma leiocarpa Bern. were planted separately for comparison. No difference in germination of the seeds or growth of the seedlings for the three types of samples was noticed.

  2. Development of a core outcome set for medication review in older patients with multimorbidity and polypharmacy: a study protocol

    Directory of Open Access Journals (Sweden)

    Beuscart JB

    2017-08-01

    Full Text Available Jean-Baptiste Beuscart,1 Olivia Dalleur,1 Benoit Boland,2 Stefanie Thevelin,1 Wilma Knol,3 Shane Cullinan,4 Claudio Schneider,5 Denis O’Mahony,6 Nicolas Rodondi,4,7 Anne Spinewine1,8 1Université catholique de Louvain, Louvain Drug Research Institute, Clinical Pharmacy Research Group, Brussels, Belgium; 2Geriatric Medicine, Cliniques universitaires Saint-Luc, Brussels, Université catholique de Louvain, Belgium; 3Department of Geriatric Medicine and Expertise Centre Pharmacotherapy in Old Persons (EPHOR, University Medical Centre Utrecht, Netherlands; 4School of Pharmacy, Royal College of Surgeons in Ireland, Dublin, Ireland; 5Department of General Internal Medicine, Bern University Hospital, Bern, Switzerland; 6Department of Medicine (Geriatrics, University College Cork, Cork, Ireland; 7Institute of Primary Health Care (BIHAM, University of Bern, Bern, Switzerland; 8Université catholique de Louvain, CHU UCL Namur, Pharmacy Department, Yvoir, Belgium Background: Medication review has been advocated to address the challenge of polypharmacy in older patients, yet there is no consensus on how best to evaluate its efficacy. Heterogeneity of outcomes reported in clinical trials can hinder the comparison of clinical trial findings in systematic reviews. Moreover, the outcomes that matter most to older patients might be under-reported or disregarded altogether. A core outcome set can address this issue as it defines a minimum set of outcomes that should be reported in all clinical trials in any particular field of research. As part of the European Commission-funded project, called OPtimising thERapy to prevent Avoidable hospital admissions in the Multimorbid elderly, this paper describes the methods used to develop a core outcome set for clinical trials of medication review in older patients with multimorbidity. Methods/design: The study was designed in several steps. First, a systematic review established which outcomes were measured in published

  3. A Twistor Approach to One-Loop Amplitudes in N=1 Supersymmetric Yang-Mills Theory

    CERN Document Server

    Bedford, J; Spence, B; Travaglini, G; Bedford, James; Brandhuber, Andreas; Spence, Bill; Travaglini, Gabriele

    2004-01-01

    We extend the twistor string theory inspired formalism introduced in hep-th/0407214 for calculating loop amplitudes in N=4 super Yang-Mills theory to the case of N=1 (and N=2) super Yang-Mills. Our approach yields a novel representation of the gauge theory amplitudes as dispersion integrals, which are surprisingly simple to evaluate. As an application we calculate one-loop maximally helicity violating (MHV) scattering amplitudes with an arbitrary number of external legs. The result we obtain agrees precisely with the expressions for the N=1 MHV amplitudes derived previously by Bern, Dixon, Dunbar and Kosower using the cut-constructibility approach.

  4. Multiphoton amplitudes and generalized LKF transformation in scalar QED using the worldline formalism

    CERN Document Server

    Ahmadiniaz, Naser; Schubert, Christian

    2016-01-01

    We apply the worldline formalism to scalar quantum electrodynamics (QED) to find a Bern-Kosower type master formula for generalized Compton scattering, on-shell and off-shell. Moreover, we use it to study the non-perturbative gauge parameter dependence of amplitudes in scalar QED and, as our main result, find a simple non-perturbative transformation rule under changes of this parameter in x-space in terms of conformal cross ratios. This generalizes the well-known Landau-Khalatnikov-Fradkin transformation (LKFT). We also exemplify how the LKFT works in perturbation theory.

  5. Constant External Fields in Gauge Theory and the Spin 0, 1/2, 1 Path Integrals

    CERN Document Server

    Reuter, M; Schubert, C; Reuter, Martin; Schmidt, Michael G.; Schubert, Christian

    1996-01-01

    We investigate the usefulness of the ``string-inspired technique'' for gauge theory calculations in a constant external field background. Our approach is based on Strassler's worldline path integral approach to the Bern-Kosower formalism, and on the construction of worldline (super--) Green's functions incorporating external fields as well as internal propagators. The worldline path integral representation of the gluon loop is reexamined in detail. We calculate the two-loop effective actions induced for a constant external field by a scalar and spinor loop, and the corresponding one-loop effective action in the gluon loop case.

  6. Visit of Her Royal Highness Princess Maha Chakri Sirindhorn, Thailand

    CERN Multimedia

    Patrice Loïez

    2000-01-01

    Her Royal Highness Princess Maha Chakri Sirindhorn of Thailand (left) visiting DELPHI with Spokesman, Tiziano Camporesi, and Prapol Assavavirulhakarn, Pattaratorn Chirapravati, Claude Détraz, CERN Director for Fixed Target andFuture Programmes and Richard Breedon, University of California. No. 05: Princess Maha Chakri Sirindhorn and Daniel Treille, former spokesman of Delphi. No. 31: in Delphi experiment. No. 35: H.E. Mr. Virasakdi Futrakul, Ambassador, Permanent Representative ofThailand, Geneva with H.E. Dr. Ronarong Nopakun, Ambassador of the Thai Embassy in Bern

  7. European School of High-Energy Physics, Beatenberg, Switzerland, 26 August - 8 September 2001

    CERN Multimedia

    2000-01-01

    The 2001 European School of High-Energy Physics (formerly the CERN-JINR School of Physics) will be organized jointly by the European Organization for Nuclear Research (CERN), Geneva, Switzerland and the Joint Institute for Nuclear Research (JINR), Dubna, Russia, together with the University of Bern. The basic aim of the School is to teach various aspects of high-energy physics, but especially theoretical physics, to young experimental physicists, mainly from the Member States of CERN and of JINR. The Schools of Physics are designed to give a survey of up-to-date information, rather than to be a training course.

  8. Bibliography and References

    OpenAIRE

    2014-01-01

    1. Books and articles The Association of Chartered Certified Accountants, “Tax principles: from Adam smith to Barack Obama,” ACCA Policy Paper, 2009. Division Etudes et supports, AFC Berne, “L’impôt fédéral anticipé.” Etat de la législation: 1.1.2010, 2010. Michael Ambühl, “Switzerland’s Future as a Competitive Financial Center,” keynote speech at the AGM of the Swiss-American Chamber of Commerce, 20.6.2011, Ruschlikon Zurich. Raymond Aron, Peace and War: A Theory of International Relations,...

  9. Theory and practice as cultural forms and the research design on The open school program in the Danish school reform

    DEFF Research Database (Denmark)

    Knudsen, Lars Emmerik Damgaard; Haastrup, Lisbeth

    2015-01-01

    of teaching, supervising, mentoring and studying. We hereby took on the challenge of suggesting a ‘theory and practice didactics’ by turning to creativity research and social learning theory in order to transgress the observed routinized theory and practice relations embedded in the topos practices (Haastrup....... Eikeland, O. (2008). The Ways of Aristotle: Aristotelian Phrónêsis, Aristotelian Philosophy of Dialogue, and Action Research. Bern, Peter Lang. Højrup, T. (2003). State, Culture and Life-Modes. The Foundations of Life-Mode Analysis. Hants, Ashgate Publishing Limited Haastrup, L & Knudsen, L. E. D. (2014...

  10. Bibliografía

    OpenAIRE

    Mankeliunas, Mateo V.; Ardila y Ardila, Rubén

    2013-01-01

    A. Nyman. Die Schulen der neueren Psychologie. Autorisierte Uebersezung aus dem Schwedischen von Dr. Ewald Bohm. Bern - Stuttgart: Verlag Hans Huber, 1966, 258 pags., 17 ilustraclones, Precio: Schfr, 28.00. /  P. Foulquie (con la colaboracien de G. Deledalle). Psicología Contemporánea. Traducción de Luis Cuellar Bassals. Barcelona - Madrid: Ed. Labor, 1965, 392 pags. Precio: $ 97.50. /  F. L. Mueller.La psicología contemporánea. Traducción de Julieta Campos. México- Buenos Aires: Fondo de Cul...

  11. Draft law concerning the agreement concluded on 22 October 1986 by the Federal Republic of Germany and the Swiss Confederation, on third party liability in the nuclear energy field

    Energy Technology Data Exchange (ETDEWEB)

    1987-10-06

    The bill is intented to improve the liability regime for the protection of the population of the two neighbour countries against possible transfrontier effects of nuclear facilities of the two countries. The third-party liability agreement has been signed on 22 October 1986 in Bern/Switzerland to the effect that the Swiss Confederation is regarded as having acceded to the Paris Convention on Third Party Liability. The bill in hand is to create the basis for a ratification of the agreement, in accordance with Art. 59, para 2, 1st sentence of the Basic Law.

  12. Method for the appraisal and classification of the suitability for use of watercourses - Appendices; Methodik zur Bewertung und Klassierung der Nutzungseignung von Fliessgewaesserstrecken. Grundlagen fuer die raeumliche Prioritaetensetzung bei der Wasserkraftnutzung und dem Schutz von Gewaessern - Annex 2: Beruecksichtigung der Schutz- und Nutzungsinteressen bei der Wasserkraftnutzung (ohne Karten)

    Energy Technology Data Exchange (ETDEWEB)

    Wehse, H.

    2009-10-15

    These appendices to final report for the Swiss Federal Office of Energy (SFOE) that discusses the fundamentals for setting priorities for the use of hydropower and the protection of streams and rivers present a rich bibliography on the subject and a documentation on current projects. Also a comprehensive list of criteria and a selection of particularly relevant criteria is presented. Also, the 'Master-plan river ecology' for the Canton of Berne, Switzerland, is included. A further appendix discusses the methodology used for the definition of potential for improvement as far as river morphology is concerned.

  13. The 2016 Frontiers in Medicinal Chemistry Conference in Bonn.

    Science.gov (United States)

    Müller, Christa E; Thimm, Dominik; Baringhaus, Karl-Heinz

    2017-01-05

    Pushing the frontiers of medicinal chemistry: Christa Müller, Dominik Thimm, and Karl-Heinz Baringhaus look back at the events of the 2016 Frontiers in Medicinal Chemistry (FiMC) Conference held in Bonn, Germany. The report highlights the themes & talks in the annual conference hosted by the Joint Division of Medicinal Chemistry of the German Pharmaceutical Society (DPhG) and German Chemical Society (GDCh). It is also an invitation to the 2017 conference in Bern, Switzerland this February 12-15.

  14. Gauge amplitude identities by on-shell recursion relation in S-matrix program

    Science.gov (United States)

    Feng, Bo; Huang, Rijun; Jia, Yin

    2011-01-01

    Using only the Britto-Cachazo-Feng-Witten (BCFW) on-shell recursion relation we prove color-order reversed relation, U(1)-decoupling relation, Kleiss-Kuijf (KK) relation and Bern-Carrasco-Johansson (BCJ) relation for color-ordered gauge amplitude in the framework of S-matrix program without relying on Lagrangian description. Our derivation is the first pure field theory proof of the new discovered BCJ identity, which substantially reduces the color-ordered basis from (n-2)! to (n-3)!. Our proof gives also its physical interpretation as the mysterious bonus relation with 1/z behavior under suitable on-shell deformation for no adjacent pair.

  15. Probabilistic disaggregation model with application to natural hazard risk assessment of portfolios

    DEFF Research Database (Denmark)

    Custer, Rocco; Nishijima, Kazuyoshi

    are usually deterministic and make use of auxiliary indicator, such as land cover, to spatially distribute exposures. As the dependence between auxiliary indicator and disaggregated number of exposures is generally imperfect, uncertainty arises in disaggregation. This paper therefore proposes a probabilistic...... disaggregation model that considers the uncertainty in the disaggregation, taking basis in the scaled Dirichlet distribution. The proposed probabilistic disaggregation model is applied to a portfolio of residential buildings in the Canton Bern, Switzerland, subject to flood risk. Thereby, the model is verified...

  16. Environmental Policy Issues Affecting the United States Army in Its Overseas Activities

    Science.gov (United States)

    1989-01-01

    regretting sauvage at du milieu naturel de I’Europe (Convention that this activity is restrained by the limited funds de Berne). et regrettant que cette...sauvage et du milieu naturel de l’Europe; ,c. follow up the Assembly’s longstanding request c. de donner suite A la demande ddjh ancienne de that the...minerals, such as mLu’ble. sand, gravel, shale, salt, phosphates and potash. (d, Etcaction -of coal and lignite by underground mining, (e) E r-ort o

  17. Field structure and electron life times in the MEFISTO electron cyclotron resonance ion source

    Energy Technology Data Exchange (ETDEWEB)

    Bodendorfer, M. [EPFL - Ecole Polytechnique Federale de Lausanne (Switzerland); University of Berne, Institute of Physics, Space Research and Planetary Sciences, Siedlerstrasse 5, 3012 Berne (Switzerland)], E-mail: michael.bodendorfer@space.unibe.ch; Altwegg, K. [University of Berne, Institute of Physics, Space Research and Planetary Sciences, Siedlerstrasse 5, 3012 Berne (Switzerland); Shea, H. [EPFL - Ecole Polytechnique Federale de Lausanne (Switzerland); Wurz, P. [University of Berne, Institute of Physics, Space Research and Planetary Sciences, Siedlerstrasse 5, 3012 Berne (Switzerland)

    2008-03-15

    The complex magnetic field of the permanent magnet electron cyclotron resonance (ECR) ion source MEFISTO located at the University of Berne has been numerically simulated. For the first time the magnetized volume qualified for electron cyclotron resonance at 2.45 GHz and 87.5 mT has been analyzed in highly detailed 3D simulations with unprecedented resolution. New results were obtained from the numerical simulation of 25,211 electron trajectories. The evident characteristic ion sputtering trident of hexapole confined ECR ion sources has been identified with the field and electron trajectory distribution. Furthermore, unexpected long electron trajectory lifetimes were found.

  18. Field structure and electron life times in the MEFISTO electron cyclotron resonance ion source

    Science.gov (United States)

    Bodendorfer, M.; Altwegg, K.; Shea, H.; Wurz, P.

    2008-03-01

    The complex magnetic field of the permanent magnet electron cyclotron resonance (ECR) ion source MEFISTO located at the University of Berne has been numerically simulated. For the first time the magnetized volume qualified for electron cyclotron resonance at 2.45 GHz and 87.5 mT has been analyzed in highly detailed 3D simulations with unprecedented resolution. New results were obtained from the numerical simulation of 25,211 electron trajectories. The evident characteristic ion sputtering trident of hexapole confined ECR ion sources has been identified with the field and electron trajectory distribution. Furthermore, unexpected long electron trajectory lifetimes were found.

  19. Field structure and electron life times in the MEFISTO Electron Cyclotron Resonance Ion Source

    CERN Document Server

    Bodendorfer, Michael; Shea, Herbert; Wurz, Peter

    2008-01-01

    The complex magnetic field of the permanent-magnet electron cyclotron resonance (ECR) ion source MEFISTO located at the University of Bern have been numerically simulated. For the first time the magnetized volume qualified for electron cyclotron resonance at 2.45 GHz and 87.5 mT has been analyzed in highly detailed 3D simulations with unprecedented resolution. New results were obtained from the numerical simulation of 25211 electron trajectories. The evident characteristic ion sputtering trident of hexapole confined ECR sources has been identified with the field and electron trajectory distribution. Furthermore, unexpected long electron trajectory lifetimes were found.

  20. Catalogare & comprare: la nuova gioventù dei pezzi da museo

    Directory of Open Access Journals (Sweden)

    Paolo Caponi

    2011-04-01

    Full Text Available Catalogare & comprare: la nuova gioventù dei pezzi da museo∗John Soane, Per una storia della mia casa. Primo abbozzo. A cura di Caroline Patey, Palermo, Sellerio Editore, 2010, pp.128, ISBN 88-389-2342-6Caroline Patey, Laura Scuriatti (eds, The Exhibit in the Text. The Museological Practices of Literature, Bern, Peter Lang, 2009, pp. 282, ISBN 978-3-03911-377-4di Paolo Caponi ∗ First published in: Caponi, Paolo. "Catalogare & comprare: la nuova gioventù dei pezzi da museo." AltreModernità [Online], 0.4 (2011: 321-323. Web. 27 Mar. 2011

  1. Monodromy and Jacobi-like Relations for Color-Ordered Amplitudes

    CERN Document Server

    Bjerrum-Bohr, N E J; Sondergaard, Thomas; Vanhove, Pierre

    2010-01-01

    We discuss monodromy relations between different color-ordered amplitudes in gauge theories. We show that Jacobi-like relations of Bern, Carrasco and Johansson can be introduced in a manner that is compatible with these monodromy relations. The Jacobi-like relations are not the most general set of equations that satisfy this criterion. Applications to supergravity amplitudes follow straightforwardly through the KLT-relations. We explicitly show how the tree-level relations give rise to non-trivial identities at loop level.

  2. The Lazarus effect

    CERN Multimedia

    Laurent Guiraud

    1998-01-01

    Members of the RD39 collaboration stage a demonstration of the Lazarus effect in the CERN cryolab. At the LHC experiments, the front-line inner detectors - trackers - will be traversed by a mammoth thousand million million passing particles per square centimetre over the lifetimes of the experiments. After long exposure to passing particles, defects appear in the silicon and the signal is destroyed. A group of physicists at Bern University have found that at temperatures below 100 K, dead detectors apparently come back to life. They're calling their discovery the Lazarus effect after the Biblical character raised from the dead by Jesus after he had been entombed for four days.

  3. Project Inner Brick - Colorful Plastic Bricks in Psychotherapy - An Introduction to Methodology

    Directory of Open Access Journals (Sweden)

    Neidert László

    2015-06-01

    Full Text Available PIB is a research project pertaining to the psychotherapeutic potential of Lego bricks. This is based on Lego Group’s own method called Lego Seriousplay and Eric Berne's transactional analysis as a theoretical background. If we see it from the Lego’s aspect, our plan is a training like LSP. It is only alike because of the special application. We made a lot of modifications according to the original methodology. In this document we would like to present details of our research we have been working on for almost two years. The characteristics of our methodology will be illustrated, too.

  4. A composição da página noticiosa nos jornais digitais: o estado da questão

    Directory of Open Access Journals (Sweden)

    Moherdaui, Luciana

    2009-01-01

    Full Text Available Este artigo apresenta o estado da questão da composição da página noticiosa no jornalismo digital de 1991, quando Tim Bernes Lee anunciou a world wide web, até os dias atuais. Para verificar rupturas e descontinuidades nos projetos gráficos, a análise tem como base fundamental das proposições o newsmaking (Galtung e Ruge, 1965, o design informacional (Harrower, 2002; Garcia, 1981 e 2005; Amaral, 2004 e os conceitos de remediação (Bolter e Grusin, 2000 e teleação (Manovich, 2001

  5. Cognitively writing: examining the writer-reader dynamic in creative writing

    OpenAIRE

    Krug,Matthias

    2012-01-01

    La propuesta para esta tesis doctoral en Estudios lingüísticos y literarios ingleses y norteamericanos, acordada bajo la dirección y supervisión del Catedrático Enrique Bernárdez de la Facultad de Filología Inglesa I, es un estudio original, que aporta una nueva contribución al campo de los estudios cognitivos. En particular, al campo cognitivo aplicado a la escritura creativa, que será el centro de este estudio; de manera que se puedan determinar los procesos cognitivos implicados en la tran...

  6. Teatrimaailm / Mari Kolle, Katrin Talts

    Index Scriptorium Estoniae

    Kolle, Mari

    2005-01-01

    23. märtsil avatakse unikaalne interneti-projekt "Cultu.Ru!" ; Londoni Criterion Theatre'is etendub "Amajuba. Me tõuseme lendu nagu tuvid", mida esitavad Lõuna-Aafrika viis näitlejat, kes räägivad oma elust ; ITI on tänavu ülemaailmse teatripäeva pühendanud naistele, korraldades rahvusvahelise kübernäituse "Naised teatris", mis esitleb eri maade teatripraktikuid : naislavastajaid, näitekirjanikke ja näitlejannasid XX sajandi II poolel ; Pariisis tegutsevast Päikeseteatrist ning teatri asutajast ja juhist A. Mnouchkine'ist

  7. Teatrimaailm / Mari Kolle, Katrin Talts

    Index Scriptorium Estoniae

    Kolle, Mari

    2005-01-01

    23. märtsil avatakse unikaalne interneti-projekt "Cultu.Ru!" ; Londoni Criterion Theatre'is etendub "Amajuba. Me tõuseme lendu nagu tuvid", mida esitavad Lõuna-Aafrika viis näitlejat, kes räägivad oma elust ; ITI on tänavu ülemaailmse teatripäeva pühendanud naistele, korraldades rahvusvahelise kübernäituse "Naised teatris", mis esitleb eri maade teatripraktikuid : naislavastajaid, näitekirjanikke ja näitlejannasid XX sajandi II poolel ; Pariisis tegutsevast Päikeseteatrist ning teatri asutajast ja juhist A. Mnouchkine'ist

  8. Questions of copyright.

    Science.gov (United States)

    Anfray, Caroline; Emery, Marie-Pierre; Conway, Katrin; Acquadro, Catherine

    2012-01-31

    The Berne Convention and the national laws on intellectual property fully apply to PRO instruments. The identification of and access to an original PRO instrument is often associated with copyright ownership. This is the copyright holder of the instrument who will control its access (distribution and reproduction), its adaptation or modification, and its translation. Copyright is a means to protect the integrity of an instrument. The ownership of an instrument should be defined in the beginning between all parties involved, and each step of the instrument's life, including distribution, should be anticipated for purpose of copyright.

  9. Hospital for joint diseases participates in international spine registry Spine Tango after successful pilot study.

    Science.gov (United States)

    Röder, Christoph; Errico, Thomas J; Spivak, Jeffrey M; Murray, M; Protopsaltis, T; Lis, A; Nordin, Margareta; Bendo, John

    2012-01-01

    Spine Tango is currently the only international spine registry in existence. It was developed under the auspices of Eurospine, the Spine Society of Europe, and is hosted at the University of Bern, Switzerland. The HJD Spine Center successfully tested Spine Tango during a 3-month pilot study and has since expanded documentation activities to more surgeons. Workflow integration and dedicated research staff are key factors for such an endeavor. Participation enables benchmarking against national and international peers and outcome research and quality assurance of surgical and non-surgical treatments.

  10. Paul Klee Centre - impressive monument in a fruitful environment; Beeindruckendes Baumonument im Fruchtland

    Energy Technology Data Exchange (ETDEWEB)

    Mayer, C. M.

    2005-07-01

    This article takes a look at the architectural and technical services aspects of the new Paul Klee Centre built by star-architect Renzo Piano on the outskirts of Berne, Switzerland. The centre, which houses around 4,000 works by the famous artist, is considered to be a work-of-art itself. The museum, with its wave-form construction, not only impresses through its architecture, but also by its technical installations. In particular, the climatic conditions required by the works of art are briefly looked at and the technical installations used to provide the exact climatic conditions are briefly described.

  11. Cendrars et Pilniak, une poignée de main

    OpenAIRE

    Khlopina, Oxana

    2014-01-01

    C’était en novembre 2001, lorsque les archives de Berne ouvrirent leurs portes à une jeune doctorante dont le seul avantage était de savoir lire le russe. Mon ambition était alors d’écrire une thèse sur Blaise Cendrars et la Russie, et je traquais le moindre détail qui les rapprochait, avec l’infatigable enthousiasme qu’on ne peut avoir qu’à vingt-deux ans. Le travail fut gratifiant, les preuves accusant Cendrars de russophilie étant très nombreuses. Les fiches de lectures, les lettres qui té...

  12. Multiphoton Amplitudes and Generalized LKF Transformation in Scalar QED Using the Worldline Formalism

    Science.gov (United States)

    Ahmadiniaz, N.; Bashir, A.; Schubert, C.

    2017-03-01

    We apply the worldline formalism to scalar quantum electrodynamics (QED) to find a Bern-Kosower type master formula for generalized Compton scattering, on-shell and off-shell. Moreover, we use it to study the non-perturbative gauge parameter dependence of amplitudes in scalar QED and, as our main result, find a simple non-perturbative transformation rule under changes of this parameter in x-space in terms of conformal cross ratios. This generalizes the well-known Landau-Khalatnikov-Fradkin transformation (LKFT). We also exemplify how this generilized LKFT works in perturbation theory.

  13. A Critical Analysis of Globalilzation in the Context of Africa Underdevelopment

    Directory of Open Access Journals (Sweden)

    Mohammed O. Lawal

    2013-07-01

    While globalization is considered as a pride to the West and Europe, Africa is still being regarded as localized. The paper goes filrther to address the imbalance and disparity that have existed bern.'een the developed and underdeveloped countries in the areas of electronic, commerce, Information Communication Technology (ICT among others. Also, the opportunities and challenges posed by globalization are critically focused. The paper identifies the Aji-ican problems of underdevelopment and proposes strategies by which these problems could be solved so that Africa would be able to 'catch up' in the globalization process.

  14. Advantages and limits to the fermentation of easily-degradable industrial and food wastes in sewage treatment works; Vorteile und Grenzen der Vergaerung von leicht abbaubaren Industrie- und Lebensmittelabfaellen in Abwasserreinigungsanlagen. Vergleich zu landwirtschaftlichen Anlagen - Schlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Bachmann, N.; Wellinger, A. [Nova Energie GmbH, Aadorf (Switzerland); Bachmann, N. [EREP SA, Aclens (Switzerland)

    2009-12-15

    This final report for the Swiss Federal Office of Energy (SFOE) takes a look at the advantages and limits that apply to the fermentation of industrial and food wastes in sewage treatment facilities in comparison to agricultural installations. For this ecological review, a material-flow analysis was made which permitted the nutrient loss to be quantified. The report presents data on the energy and carbon dioxide balances for the method and also looks at the method from an economical point of view. Co-fermentation in the wastewater treatment plant in Berne, Switzerland, and in agricultural plant are examined.

  15. Comment on the Alday-Maldacena solution in calculating scattering amplitude via AdS/CFT

    OpenAIRE

    Yang, Gang

    2007-01-01

    Following the recent proposal of Alday and Maldacena to obtain the strong coupling scattering amplitude in N=4 SYM via AdS/CFT, we point out that a unique solution can be obtained by imposing all the Virasoro constraints. In the case of four-gluon scattering, this solution is identical to the Alday-Maldacena solution, which is in accordance with the ansatz of Bern, Dixon and Smirnov. This also solves the moduli space problem of the four-point solution in a recent paper of Mironov, Morozov and...

  16. Color-kinematic duality in ABJM theory without amplitude relations

    Science.gov (United States)

    Sivaramakrishnan, Allic

    2017-01-01

    We explicitly show that the Bern-Carrasco-Johansson color-kinematic duality holds at tree level through at least eight points in Aharony-Bergman-Jafferis-Maldacena theory with gauge group SU(N) × SU(N). At six points we give the explicit form of numerators in terms of amplitudes, displaying the generalized gauge freedom that leads to amplitude relations. However, at eight points no amplitude relations follow from the duality, so the diagram numerators are fixed unique functions of partial amplitudes. We provide the explicit amplitude-numerator decomposition and the numerator relations for eight-point amplitudes.

  17. Polymalic acid fermentation by Aureobasidium pullulans for malic acid production from soybean hull and soy molasses: Fermentation kinetics and economic analysis.

    Science.gov (United States)

    Cheng, Chi; Zhou, Yipin; Lin, Meng; Wei, Peilian; Yang, Shang-Tian

    2017-01-01

    Polymalic acid (PMA) production by Aureobasidium pullulans ZX-10 from soybean hull hydrolysate supplemented with corn steep liquor (CSL) gave a malic acid yield of ∼0.4g/g at a productivity of ∼0.5g/L·h. ZX-10 can also ferment soy molasses, converting all carbohydrates including the raffinose family oligosaccharides to PMA, giving a high titer (71.9g/L) and yield (0.69g/g) at a productivity of 0.29g/L·h in fed-batch fermentation under nitrogen limitation. A higher productivity of 0.64g/L·h was obtained in repeated batch fermentation with cell recycle and CSL supplementation. Cost analysis for a 5000 MT plant shows that malic acid can be produced at $1.10/kg from soy molasses, $1.37/kg from corn, and $1.74/kg from soybean hull. At the market price of $1.75/kg, malic acid production from soy molasses via PMA fermentation offers an economically competitive process for industrial production of bio-based malic acid.

  18. Spectrogram Analysis of Complete Dentures with Different Thickness and Palatal Rugae Materials on Speech Production

    Directory of Open Access Journals (Sweden)

    Hamada Zaki Mahross

    2015-01-01

    Full Text Available Objective. To investigate the influence of reproduction of different thickness and palatal rugae materials on complete dentures speech using Computerized Speech Lab (CSL (spectrogram. Materials and Methods. Three completely edentulous male patients (aged 50–60 years were selected for reading a paragraph. Twelve upper dentures were constructed, four for each patient. The patients’ speech groups were divided into five groups, Group I: patients without dentures; Group II: patients rehabilitated with conventional acrylic dentures; Group III: patients with conventional acrylic dentures with rugae reproduction; Group IV: patients with dentures with metallic framework of minimal thickness and direct ragged metallic palatal surface at rugae area; Group V: patients with dentures with palatal rugae constructed from resilient acrylic resin material with thickness less than conventional denture. Speech samples were recorded after insertion of each denture for groups using Computerized Speech Lab (CSL (spectrogram. The sounds selected were lingopalatal /s/z/sh/t/d/ and /l/. Results. Group III produced high mean significant difference with /sh/t/ sound. For Group IV, the difference was noticed with /s/z/sh/t/ and /d/ sounds, while for Group V the difference was shown with /z/l/ sound (P<0.05. Conclusion. It is recommended to reproduce the rugae area in complete denture because the phonetic quality of complete denture with rugae is superior to the conventional denture.

  19. Entanglement entropy of a Maxwell field on the sphere

    CERN Document Server

    Casini, Horacio

    2015-01-01

    We compute the logarithmic coefficient of the entanglement entropy on a sphere for a Maxwell field in $d=4$ dimensions. In spherical coordinates the problem decomposes into one dimensional ones along the radial coordinate for each angular momentum. We show the entanglement entropy of a Maxwell field is equivalent to the one of two identical massless scalars from which the mode of $l=0$ has been removed. This shows the relation $c^M_{\\log}=2 (c^S_{\\log}-c^{S_{l=0}}_{\\log})$ between the logarithmic coefficient in the entropy for a Maxwell field $c^M_{\\log}$, the one for a $d=4$ massless scalar $c_{\\log}^S$, and the logarithmic coefficient $c^{S_{l=0}}_{\\log}$ for a $d=2$ scalar with Dirichlet boundary condition at the origin. Using the accepted values for these coefficients $c_{\\log}^S=-1/90$ and $c^{S_{l=0}}_{\\log}=1/6$ we get $c^M_{\\log}=-16/45$, which coincides with Dowker's calculation, but does not match the coefficient $-\\frac{31}{45}$ in the trace anomaly for a Maxwell field. We have numerically evaluate...

  20. Development of a practical and cost-effective medium for bioethanol production from the seaweed hydrolysate in surface-aerated fermentor by repeated-batch operation.

    Science.gov (United States)

    Lee, Sang-Eun; Lee, Ji-Eun; Shin, Ga-Young; Choi, Woon Yong; Kang, Do Hyung; Lee, Hyeon-Yong; Jung, Kyung-Hwan

    2012-01-01

    To develop a practical and cost-effective medium for bioethanol production from the hydrolysate of seaweed Sargassum sagamianum, we investigated the feasibility and performance of bioethanol production in CSL (cornsteep liquor)-containing medium, where yeast Pichia stipitis was used and the repeated batch was carried out in a surface-aerated fermentor. The optimal medium replacement time during the repeated operation was determined to be 36 h, and the surface aeration rates were 30 and 100 ml/min. Under these conditions, the repeatedbatch operation was successfully carried out for 6 runs (216 h), in which the maximum bioethanol concentrations reached about 11-12 g/l at each batch operation. These results demonstrated that bioethanol production could be carried out repeatedly and steadily for 216 h. In these experiments, the total cumulative bioethanol production was 57.9 g and 58.0 g when the surface aeration rates were 30 ml/min and 100 ml/min, respectively. In addition, the bioethanol yields were 0.43 (about 84% of theoretical value) and 0.44 (about 86% of theoretical value) when the surface aeration rates were 30 ml/min and 100 ml/min, respectively. CSL was successfully used as a medium ingredient for the bioethanol production from the hydrolysate of seaweed Sargassum sagamianum, indicating that this medium may be practical and cost-effective for bioethanol production.