Memory transfer for emotionally valenced words between identities in dissociative identity disorder.

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Huntjens, Rafaële J C; Peters, Madelon L; Woertman, Liesbeth; van der Hart, Onno; Postma, Albert

2007-04-01

The present study aimed to determine interidentity retrieval of emotionally valenced words in dissociative identity disorder (DID). Twenty-two DID patients participated together with 25 normal controls and 25 controls instructed to simulate DID. Two wordlists A and B were constructed including neutral, positive and negative material. List A was shown to one identity, while list B was shown to another identity claiming total amnesia for the words learned by the first identity. The identity claiming amnesia was tested for intrusions from list A words into the recall of words from list B and recognition of the words learned by both identities. Test results indicated no evidence of total interidentity amnesia for emotionally valenced material in DID. It is argued that dissociative amnesia in DID may more adequately be described as a disturbance in meta-memory functioning instead of an actual retrieval inability.

Pictorial Memory – Manners of the Individual Identity Construction

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Milena Gnjatović

2015-08-01

Full Text Available The title of this study directly refers to the importance of the images, meaning material objects, personal memories or literal images – photographs one elects from the past in order to build up the individual identity and present it to others. Long ago, during the antique age, techniques of the remembrance by using pictorial memory and sequencing images from the past had been created, and those just developed during centuries. The goal of this paper is to stress that, basic concepts of the self representation did not change, but just used different media through time. In the first part of the paper, the difference between terms memory and remembrance, their relation to the culture and reasons why one remembers something will be discussed. As it is tended to be shown, the remembrance is always “pictorial”, one always puts elected images of the past in the exact order and creates its own identity. Therefore, in the second part of this study, the idea of individual identity, creation of it and the representation of the self identity to the others will be examined and explained in the context of the pictorial memory and heritage on the one hand, and social determination on the other. Inspired by the wholes one leaves in its personal life story when presenting it to others, the need of forgetting as constituent part of memory will also be stressed. Finally, the last part of this study points out that we still use the same concepts of remembering, electing and presenting images from the past in the creation of the image of ourselves, using the most popular media today - virtual space.

Gender Identification Moderates Social Identity Threat Effects on Working Memory

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Kaiser, Cheryl R.; Hagiwara, Nao

2011-01-01

This investigation examined whether gender identification moderates women's working memory following exposure to situations that threaten the integrity of their gender group. Young adults read sentences that either threatened women's gender identity (in the social identity threat condition) or did not threaten this identity (in the control…

REGIONAL AUTHORS SELF-IDENTITY DEMONSTRATION IN MEMORIAL CONTEXTS

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Mariya Victorovna Vekkesser

2017-11-01

Full Text Available Purpose. The article is devoted to the pressing issue of regional identity preservation under conditions of linguoculturological globalization in modern society. The purpose of our research is to identify verbal means of expressing regional self-identification of narrators in the memorial context. The object is the self-identification of the narrator in memorial genre and the subject is verbal means of expressing regional self-identification. Methodology and methods of work. An appeal to the memorial genre, searching linguistic methods of the regional authors self-identity is considered in a context of regional linguistic from the perspective of communicative discourse approach; discursive and contextual methods are used. Results. The article theoretically describes the memorat from the standpoint of the speech genres theory. The research shows the narrators through the actualization of language tools associate themselves with their native region, the result being the formation of regional self-identification. In the era of linguistic globalization it is important to study regional self-identification, in particular, in the context of the memorial speech genre. Practical implications. Both the article materials and results can be applied in the educational process of reading special courses on regional linguistic issues.

STEM Professionals Entering Teaching: Navigating Multiple Identities

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Grier, Jeanne M.; Johnston, Carol C.

2012-01-01

In this qualitative study, we identify the complexity of the transitioning identities of four STEM career changers to better inform teacher education programs on how to be more mindful of the needs of this population as they return to the life of a student again on their path toward a new career in teaching. Findings suggest the career changers…

Long-term memory of individual identity in ant queens

DEFF Research Database (Denmark)

Dreier, Stéphanie Agnès Jeanine; Van Zweden, Jelle Stijn; D'Ettorre, Patrizia

2007-01-01

of familiar or unfamiliar queens over time. We show that unrelated founding queens of P. villosa and Pachycondyla inversa store information on the individual identity of other queens and can retrieve it from memory after 24h of separation. Thus, we have documented for the first time that long-term memory...

Book Review: Commemoration as Conflict: Space, Memory and Identity in Peace Processes

DEFF Research Database (Denmark)

McQuaid, Sara Dybris

2016-01-01

Book rewiew: Commemoration as Conflict: Space, Memory and Identity in Peace Processes / Sara McDowell and Maire Braniff Palgrave Macmillan, 2014, 224pp., ISBN 978-0-230-27375-7......Book rewiew: Commemoration as Conflict: Space, Memory and Identity in Peace Processes / Sara McDowell and Maire Braniff Palgrave Macmillan, 2014, 224pp., ISBN 978-0-230-27375-7...

Self-defining memories, scripts, and the life story: narrative identity in personality and psychotherapy.

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Singer, Jefferson A; Blagov, Pavel; Berry, Meredith; Oost, Kathryn M

2013-12-01

An integrative model of narrative identity builds on a dual memory system that draws on episodic memory and a long-term self to generate autobiographical memories. Autobiographical memories related to critical goals in a lifetime period lead to life-story memories, which in turn become self-defining memories when linked to an individual's enduring concerns. Self-defining memories that share repetitive emotion-outcome sequences yield narrative scripts, abstracted templates that filter cognitive-affective processing. The life story is the individual's overarching narrative that provides unity and purpose over the life course. Healthy narrative identity combines memory specificity with adaptive meaning-making to achieve insight and well-being, as demonstrated through a literature review of personality and clinical research, as well as new findings from our own research program. A clinical case study drawing on this narrative identity model is also presented with implications for treatment and research. © 2012 Wiley Periodicals, Inc.

The Role of Moral Beliefs, Memories, and Preferences in Representations of Identity.

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Heiphetz, Larisa; Strohminger, Nina; Young, Liane L

2017-04-01

People perceive that if their memories and moral beliefs changed, they would change. We investigated why individuals respond this way. In Study 1, participants judged that identity would change more after changes to memories and widely shared moral beliefs (e.g., about murder) versus preferences and controversial moral beliefs (e.g., about abortion). The extent to which participants judged that changes would affect their relationships predicted identity change (Study 2) and mediated the relationship between type of moral belief and perceived identity change (Study 3). We discuss the role that social relationships play in judgments of identity and highlight implications for psychology and philosophy. Copyright © 2016 Cognitive Science Society, Inc.

Stem cell identity and template DNA strand segregation.

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Tajbakhsh, Shahragim

2008-12-01

The quest for stem cell properties to distinguish their identity from that of committed daughters has led to a re-investigation of the notion that DNA strands are not equivalent, and 'immortal' DNA strands are retained in stem cells whereas newly replicated DNA strands segregate to the differentiating daughter cell during mitosis. Whether this process occurs only in stem cells, and also in all tissues, remains unclear. That individual chromosomes can be also partitioned non-randomly raises the question if this phenomenon is related to the immortal DNA hypothesis, and it underscores the need for high-resolution techniques to observe these events empirically. Although initially postulated as a mechanism to avoid DNA replication errors, alternative views including epigenetic regulation and sister chromatid silencing may provide insights into this process.

Multiple social identities and stereotype threat: imbalance, accessibility, and working memory.

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Rydell, Robert J; McConnell, Allen R; Beilock, Sian L

2009-05-01

In 4 experiments, the authors showed that concurrently making positive and negative self-relevant stereotypes available about performance in the same ability domain can eliminate stereotype threat effects. Replicating past work, the authors demonstrated that introducing negative stereotypes about women's math performance activated participants' female social identity and hurt their math performance (i.e., stereotype threat) by reducing working memory. Moving beyond past work, it was also demonstrated that concomitantly presenting a positive self-relevant stereotype (e.g., college students are good at math) increased the relative accessibility of females' college student identity and inhibited their gender identity, eliminating attendant working memory deficits and contingent math performance decrements. Furthermore, subtle manipulations in questions presented in the demographic section of a math test eliminated stereotype threat effects that result from women reporting their gender before completing the test. This work identifies the motivated processes through which people's social identities became active in situations in which self-relevant stereotypes about a stigmatized group membership and a nonstigmatized group membership were available. In addition, it demonstrates the downstream consequences of this pattern of activation on working memory and performance. Copyright (c) 2009 APA, all rights reserved.

Memory’s Fragile Power: Crises of Memory, Identity and Narrative in Contemporary British Novels

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Birke, Dorothee

’s fragile power’ (D. Schacter), in a time when identity formation has come to be seen as an especially precarious endeavour. In particular, it shows how the texts, by employing specifically aesthetic strategies, take up, question and even transform notions about memory and identity. By drawing on concepts......Grath – explore a wide range of different ways in which the identity and memory crises of literary characters are represented. A literary-historical dimension is sketched in chapters on two ‘milestones’ in the representation of memory in the British novel: C. Dickens’ David Copperfield and V. Woolf’s Mrs Dalloway...

Cityscapes and Monuments of Western Asia Minor. Memories and Identities

DEFF Research Database (Denmark)

Mortensen, Eva; Poulsen, Birte

, finally, more than half a millennium of Roman rule. Identities are voiced through several media and visible at many levels of the ancient societies. So are the places of memory – the Lieux de Mémoire – and the studies presented here provide new insights into how human beings chose, deliberately...... and various identities. The present volume publishes 25 contributions written by scholars specializing in the history and archaeology of western Asia Minor. New and well-known material – literary, epigraphical, numismatic, and archaeological – is presented and analyzed through the twin lenses of memory...... and identity. The contributions cover more than 1000 years of cultural diversity during changing political systems, from the Lydian and Persian hegemony in the Archaic period through Athenian supremacy and Persian satrapal rule in the Classical period, then autocratic kingship in Hellenistic times until...

Narratives of Memory, Identity and Place in Male Prisoners

OpenAIRE

Medlicott, Diana

2004-01-01

This paper looks at some aspects of memory and identity in relation to male\\ud prisoners and their sense of place. Prison is, for those entering it, an exemplary\\ud life event, in terms of the jolt it gives to memory and self-image. In prison,\\ud there is all the time in the world to sit and think, and remember. Memory is a\\ud source of joy and of torment.\\ud I begin by offering a brief illustration of this. James (L6), a prisoner in his\\ud late thirties, told me about the house he lived in f...

Memory deficits for facial identity in patients with amnestic mild cognitive impairment (MCI).

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Savaskan, Egemen; Summermatter, Daniel; Schroeder, Clemens; Schächinger, Hartmut

2018-01-01

Faces are among the most relevant social stimuli revealing an encounter's identity and actual emotional state. Deficits in facial recognition may be an early sign of cognitive decline leading to social deficits. The main objective of the present study is to investigate if individuals with amnestic mild cognitive impairment show recognition deficits in facial identity. Thirty-seven individuals with amnestic mild cognitive impairment, multiple-domain (15 female; age: 75±8 yrs.) and forty-one healthy volunteers (24 female; age 71±6 yrs.) participated. All participants completed a human portrait memory test presenting unfamiliar faces with happy and angry emotional expressions. Five and thirty minutes later, old and new neutral faces were presented, and discrimination sensitivity (d') and response bias (C) were assessed as signal detection parameters of cued facial identity recognition. Memory performance was lower in amnestic mild cognitive impairment as compared to control subjects, mainly because of an altered response bias towards an increased false alarm rate (favoring false OLD ascription of NEW items). In both groups, memory performance declined between the early and later testing session, and was always better for acquired happy than angry faces. Facial identity memory is impaired in patients with amnestic mild cognitive impairment. Liberalization of the response bias may reflect a socially motivated compensatory mechanism maintaining an almost identical recognition hit rate of OLD faces in individuals with amnestic mild cognitive impairment.

TRACES OF MEMORY. PRELIMINARY REMARKS ON IDENTITY AND BIOGRAPHY OF CRIMEAN TATARS

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Irena Borowik

2011-01-01

Full Text Available The article is devoted to the preliminary analysis of biographical interviews, taken with representatives of Crimean Tatars returning to Crimean Peninsula and settling in the places that they or their ancestors used to live before deportation. The research was conducted in summer of 2008 and 2009, 20 interviews were taken with consideration of age, sex, place of living and level of education. Traces of memory are understood in this article as repeatable elements of biographical narratives. By this virtue those repeated elements refer not only to individual identity but they also build collective identity, more precisely national in this case. The key element of the article is the third part of it where relations between memory and identity are explored in collected biographies. As it appeared in all life-stories deportation from Crimea and return after years are crucial elements of construction of biographies and in all cases it has a form of trajectories. The general conclusion is that memory of these painful events and celebration of it is functional for building the strong collective identity which is based on traditional values, religious and political integration of national minority.

The Ingush’s cultural memory and social identity as a representative of repressed ethnic group

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Tatyana G. Stefanenko

2017-12-01

Full Text Available Background. The authors of the paper enquire how the continuity and maintenance of social identity is carried out from generation to generation. Particular attention is drawn to the memory of the traumatic past of the group, such as repression and deportation, as they contradict the widespread view of social identity as a tool for achieving positive individual self-esteem based on a positive image of the group. The paper assumes that cultural memory being a link between the past, the present and the future of the social group ensures the continuity of social identity. Identity that includes the comprehension and experience of the negative past of the group is also considered. Objective. The objective of this study is to justify the role of cultural memory as the basis of identification with the group and an empirical test of the relationship between the two constructs. Design. A written questionnaire was offered to 296 people aged between 17 and 70 (M = 26.22, SD = 10.0 who identified themselves as Ingush. The respondents answered questions about their social identity (ethnic, civil and religious, assessed their experiences related to the deportation fact, and substantively argued the need to preserve the cultural memory of the deportation. Conclusion. The data obtained show that the extent of identity within the group is positively correlated with the extent of the deportation experience, although these experiences are by no means positive (anger, insult, humiliation, heart pain, etc., and also with the frequency of recalling the fact of deportation and desire to learn more about this event. The obtained results confirm the suggested assumption about the role of cultural memory and allow to develop further research on clarifying the relationship between cultural memory and social identity, assessing the impact of such additional factors as group emotions, psychological well-being, etc.

From the Generation Memory to the Group Identity: The Film "A Throat Full of Strawberries"

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Nataša Delač

2015-09-01

Full Text Available In the work entitled “From the generation memory to the group identity: the film "A Throat Full of Strawberries", the influence of personal and collective memory on generation identity is analyzed. The work is based on Jan Assmann and Aleida Assmann’s theory of memory, with a special review of the books “Cultural Memory” (Jan Assmann, and “Work on the National Memory” and “The Long Shadow of the Past” (Aleida Assmann. Firstly, the analysis includes the mapping, then the explanation of the memory figures which appear in the movie. Also, the thesis which I covered in the work refers to the difference between Halbwachs’s  term “the images of memory”, and “the figure of memory” introduced by Assmann: the figures of memory are complementary to the first term “because they include not only pictorial, but narrative forms as well.” (Assmann. In this paper, the relation between personal and collective memory is examined, as well as how individual memory influences the establishment of one’s group memory, and how memory and remembrance affect what we call generation identity. The Film “A Throat Full of Strawberries” (by Srdjan Karanovic, 1985 was chosen as my case study. This movie is a sequel to the series “The Unpicked Strawberries” (Srdjan Karanovic, 1976. It tells about a reunion of the group of people of the particular generation, who evoke the memories about the events during the 60’s (the time of their youth, so the topic this film is focused on represents the starting point for the study of the generation memory and its function. The aim of this paper is to prove that generation memory has the crucial role when it comes to the creation of one’s group identity

Family matters: Familial support and science identity formation for African American female STEM majors

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Parker, Ashley Dawn

This research seeks to understand the experiences of African American female undergraduates in STEM. It investigates how familial factors and science identity formation characteristics influence persistence in STEM while considering the duality of African American women's status in society. This phenomenological study was designed using critical race feminism as the theoretical framework to answer the following questions: 1) What role does family play in the experiences of African American women undergraduate STEM majors who attended two universities in the UNC system? 2) What factors impact the formation of science identity for African American women undergraduate STEM majors who attended two universities in the UNC system? Purposive sampling was used to select the participants for this study. The researcher conducted in-depth interviews with 10 African American female undergraduate STEM major from a predominantly White and a historically Black institution with the state of North Carolina public university system. Findings suggest that African American families and science identity formation influence the STEM experiences of the African American females interviewed in this study. The following five themes emerged from the findings: (1) independence, (2) support, (3) pressure to succeed, (4) adaptations, and (5) race and gender. This study contributes to the literature on African American female students in STEM higher education. The findings of this study produced knowledge regarding policies and practices that can lead to greater academic success and persistence of African American females in higher education in general, and STEM majors in particular. Colleges and universities may benefit from the findings of this study in a way that allows them to develop and sustain programs and policies that attend to the particular concerns and needs of African American women on their campuses. Finally, this research informs both current and future African American female

The making of autobiographical memory: intersections of culture, narratives and identity.

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Fivush, Robyn; Habermas, Tilmann; Waters, Theodore E A; Zaman, Widaad

2011-10-01

Autobiographical memory is a uniquely human form of memory that integrates individual experiences of self with cultural frames for understanding identities and lives. In this review, we present a theoretical and empirical overview of the sociocultural development of autobiographical memory, detailing the emergence of autobiographical memory during the preschool years and the formation of a life narrative during adolescence. More specifically, we present evidence that individual differences in parental reminiscing style are related to children's developing autobiographical narratives. Parents who structure more elaborated coherent personal narratives with their young children have children who, by the end of the preschool years, provide more detailed and coherent personal narratives, and show a more differentiated and coherent sense of self. Narrative structuring of autobiographical remembering follows a protracted developmental course through adolescence, as individuals develop social cognitive skills for temporal understanding and causal reasoning that allows autobiographical memories to be integrated into an overarching life narrative that defines emerging identity. In addition, adolescents begin to use culturally available canonical biographical forms, life scripts, and master narratives to construct a life story and inform their own autobiographical narrative identity. This process continues to be socially constructed in local interactions; we present exploratory evidence that parents help adolescents structure life narratives during coconstructed reminiscing and that adolescents use parents and families as a source for their own autobiographical content and structure. Ultimately, we argue that autobiography is a critical developmental skill; narrating our personal past connects us to our selves, our families, our communities, and our cultures.

Popular Music Memories : Places and Practices of Popular Music Heritage, Memory and Cultural Identity

NARCIS (Netherlands)

A.J.C. van der Hoeven (Arno)

2014-01-01

markdownabstract__Abstract __ Ever since the late 1950s, people have grown up with popular music as an important element of their daily lives. This dissertation explores the connections between popular music memories, cultural identity and cultural heritage, looking at the different ways in

Identity-related autobiographical memories and cultural life scripts in patients with Borderline Personality Disorder.

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Jørgensen, Carsten René; Berntsen, Dorthe; Bech, Morten; Kjølbye, Morten; Bennedsen, Birgit E; Ramsgaard, Stine B

2012-06-01

Disturbed identity is one of the defining characteristics of Borderline Personality Disorder manifested in a broad spectrum of dysfunctions related to the self, including disturbances in meaning-generating self-narratives. Autobiographical memories are memories of personal events that provide crucial building-blocks in our construction of a life-story, self-concept, and a meaning-generating narrative identity. The cultural life script represents culturally shared expectations as to the order and timing of life events in a prototypical life course within a given culture. It is used to organize one's autobiographical memories. Here, 17 BPD-patients, 14 OCD-patients, and 23 non-clinical controls generated three important autobiographical memories and their conceptions of the cultural life script. BPD-patients reported substantially more negative memories, fewer of their memories were of prototypical life script events, their memory narratives were less coherent and more disoriented, and the overall typicality of their life scripts was lower as compared with the other two groups. Copyright © 2012 Elsevier Inc. All rights reserved.

The activation of visual memory for facial identity is task-dependent: evidence from human electrophysiology.

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Zimmermann, Friederike G S; Eimer, Martin

2014-05-01

The question whether the recognition of individual faces is mandatory or task-dependent is still controversial. We employed the N250r component of the event-related potential as a marker of the activation of representations of facial identity in visual memory, in order to find out whether identity-related information from faces is encoded and maintained even when facial identity is task-irrelevant. Pairs of faces appeared in rapid succession, and the N250r was measured in response to repetitions of the same individual face, as compared to presentations of two different faces. In Experiment 1, an N250r was present in an identity matching task where identity information was relevant, but not when participants had to detect infrequent targets (inverted faces), and facial identity was task-irrelevant. This was the case not only for unfamiliar faces, but also for famous faces, suggesting that even famous face recognition is not as automatic as is often assumed. In Experiment 2, an N250r was triggered by repetitions of non-famous faces in a task where participants had to match the view of each face pair, and facial identity had to be ignored. This shows that when facial features have to be maintained in visual memory for a subsequent comparison, identity-related information is retained as well, even when it is irrelevant. Our results suggest that individual face recognition is neither fully mandatory nor completely task-dependent. Facial identity is encoded and maintained in tasks that involve visual memory for individual faces, regardless of the to-be-remembered feature. In tasks without this memory component, irrelevant visual identity information can be completely ignored. Copyright © 2014 Elsevier Ltd. All rights reserved.

Family Matters: Familial Support and Science Identity Formation for African American Female STEM Majors

Science.gov (United States)

Parker, Ashley Dawn

2013-01-01

This research seeks to understand the experiences of African American female undergraduates in STEM. It investigates how familial factors and science identity formation characteristics influence persistence in STEM while considering the duality of African American women's status in society. This phenomenological study was designed using critical…

Transplanted Bone Marrow Mesenchymal Stem Cells Improve Memory in Rat Models of Alzheimer's Disease

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Parvin Babaei

2012-01-01

Full Text Available The present study aims to evaluate the effect of bone marrow mesenchymal stem cells (MSCs grafts on cognition deficit in chemically and age-induced Alzheimer's models of rats. In the first experiments aged animals (30 months were tested in Morris water maze (MWM and divided into two groups: impaired memory and unimpaired memory. Impaired groups were divided into two groups and cannulated bilaterally at the CA1 of the hippocampus for delivery of mesenchymal stem cells (500×103/ and PBS (phosphate buffer saline. In the second experiment, Ibotenic acid (Ibo was injected bilaterally into the nucleus basalis magnocellularis (NBM of young rats (3 months and animals were tested in MWM. Then, animals with memory impairment received the following treatments: MSCs (500×103/ and PBS. Two months after the treatments, cognitive recovery was assessed by MWM in relearning paradigm in both experiments. Results showed that MSCs treatment significantly increased learning ability and memory in both age- and Ibo-induced memory impairment. Adult bone marrow mesenchymal stem cells show promise in treating cognitive decline associated with aging and NBM lesions.

An Age-Related Dissociation of Short-Term Memory for Facial Identity and Facial Emotional Expression.

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Hartley, Alan A; Ravich, Zoe; Stringer, Sarah; Wiley, Katherine

2015-09-01

Memory for both facial emotional expression and facial identity was explored in younger and older adults in 3 experiments using a delayed match-to-sample procedure. Memory sets of 1, 2, or 3 faces were presented, which were followed by a probe after a 3-s retention interval. There was very little difference between younger and older adults in memory for emotional expressions, but memory for identity was substantially impaired in the older adults. Possible explanations for spared memory for emotional expressions include socioemotional selectivity theory as well as the existence of overlapping yet distinct brain networks for processing of different emotions. © The Author 2013. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Dissociating effects of stimulus identity and load on working memory attentional guidance: lengthening encoding time eliminates the effect of load but not identity.

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Tsvetanov, Kamen A; Arvanitis, Theodoros N; Humphreys, Glyn W

2012-01-01

Effects of the identity and load of items in working memory (WM) on visual attention were examined. With a short interval between the WM item and a subsequent search task, there were effects of both load (slowed overall reaction times, RTs, in a WM condition relative to a mere repetition baseline) and identity (search RTs were affected by re-presentation of the item in WM in the search display). As the time to encode the initial display increased, the effects of load decreased while the effect of identity remained. The data indicate that the identity of stimuli in WM can affect the subsequent deployment of attention even when time is allowed for consolidation of the stimuli in WM, and that the WM effects are not causally related to the presence of cognitive load. The results are consistent with the identity of stimuli in WM modulating attention post the memory consolidation stage.

Professional Identities and the Watershed of War: Teachers, Histories and Memories

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Peter James Cunningham

2015-02-01

Full Text Available Teachers’ individual lives and careers, identities and experiences are so various as to almost defy generalization. A valid and realistic aim of educational research is however to identify significant commonalities that enhance an understanding of the teacher’s role. Memory is a prime resource for investigating factors that change over time in the course of a career and oral history provides a means of accessing and interpreting such a rich vein of evidence. One common feature shared by teachers in Britain during the mid-twentieth century was the impact on schooling of total war.This paper draws on the memories of three teachers interviewed during a large-scale enquiry into British teachers whose careers spanned World War II. Analysis of this evidence is made with reference to recent writings on professional identity, and one aim of the paper is to promote continuing reflection on the way teachers’ identities develop under the constraints of changing historical circumstance. Testimony selected for discussion here concerns their early education and career choices, their initial teacher training and their continuing professional formation, punctured for each at different points by the single overwhelming historical event of war.The paper concludes with reference to recent literature on teacher identity, indicating how historical research and autobiographical perspectives across a whole career can contribute to contemporary understandings of how teachers perceive their work, and the formation of professional identities.

You are that smiling guy I met at the party! Socially positive signals foster memory for identities and contexts.

Science.gov (United States)

Righi, Stefania; Gronchi, Giorgio; Marzi, Tessa; Rebai, Mohamed; Viggiano, Maria Pia

2015-07-01

The emotional influence of facial expressions on memory is well-known whereas the influence of emotional contextual information on memory for emotional faces is yet to be extensively explored. This study investigated the interplay between facial expression and the emotional surrounding context in affecting both memory for identities (item memory) and memory for associative backgrounds (source memory). At the encoding fearful and happy faces were presented embedded in fear or happy scenes (i.e.: fearful faces in fear-scenes, happy faces in happy-scenes, fearful faces in happy-scenes and happy faces in fear-scenes) and participants were asked to judge the emotional congruency of the face-scene compounds (i.e. fearful faces in fear-scenes and happy faces in happy-scenes were congruent compounds). In the recognition phase, the old faces were intermixed with the new ones: all the faces were presented isolated with a neutral expression. Participants were requested to indicate whether each face had been previously presented (item memory). Then, for each old face the memory for the scene originally compounded with the face was tested by a three alternative forced choice recognition task (source memory). The results evidenced that face identity memory is differently modulated by the valence in congruent face-context compounds with better identity recognition (item memory) for happy faces encoded in happy-scenarios. Moreover, also the memory for the surrounding context (source memory) benefits from the association with a smiling face. Our findings highlight that socially positive signals conveyed by smiling faces may prompt memory for identity and context. Copyright © 2015 Elsevier B.V. All rights reserved.

The Single Sex Debate for Girls in Science: a Comparison Between Two Informal Science Programs on Middle School Students' STEM Identity Formation

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Hughes, Roxanne M.; Nzekwe, Brandon; Molyneaux, Kristen J.

2013-10-01

Currently, there are policy debates regarding the efficacy and legality of single sex formal and informal education programs. This issue is particularly poignant in science education due to the historical marginalization of women in these fields. This marginalization has resulted in women being positioned as a stigmatized group within many science, technology, engineering, and mathematics (STEM) related fields. Research points to adolescence as the age where this sense of marginalization begins to develop. As a result, policy responses have utilized various frameworks such as: increased access for women, changing pedagogy to address women's learning styles, changing the language and culture of science to prevent marginalization of stigmatized groups, and finally exploring the role that individual identity plays in the marginalization of women. This study adds to the policy debate as it applies to single sex education by comparing middle school participants' STEM identity formation during two informal science learning environments (an all girls' STEM camp and a co-educational STEM camp). Additionally, this study focuses on the influence of camp activities within two informal science education programs: particularly the provision of role models and authentic STEM research activities, as means to improve STEM identity and make these fields relevant to the lives of middle school students. The results indicate that both camps improved girls' STEM identities. These findings suggest that the single sex environment is not as important to STEM identity as the pedagogy used within the program.

De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data

NARCIS (Netherlands)

Grun, D.; Muraro, M.J.; Boisset, J.C.; Wiebrands, K.; Lyubimova, A.; Dharmadhikari, G.; Born, M. van den; Es, J. van; Jansen, E.; Clevers, H.; Koning, E.J. de; Oudenaarden, A. van

2016-01-01

Adult mitotic tissues like the intestine, skin, and blood undergo constant turnover throughout the life of an organism. Knowing the identity of the stem cell is crucial to understanding tissue homeostasis and its aberrations upon disease. Here we present a computational method for the derivation of

MEMORY PASSING AND IDENTITY FOR­MATION: GENERATIONAL NARRATIVES IN VILKYŠKIAI

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Dovilė Kulakauskienė

2014-04-01

Full Text Available Nations, confessions, and ideologies are continually mixing in frontier towns, creating a specific environment in which, on the one hand, an atmosphere of continual attrition and, on the other, tolerance and adaptation, has formed. The author has chosen to investigate the small town of Vilkyškiai, with its varied historical develop­ments among different ethnic and confessional communities. The narratives of the young gene­ration living in Vilkyškiai reflect the peculiarities of the local community’s identity formation. The youth not only learn the traditions of their own national or religious group and the main principles of moral values, but also constantly rethink the importance of their loved ones as well as their own value as people, ideas that are passed with memory narratives. Contemporary young people necessarily take into consideration contemporary cultural realia. The young generation of Vilkyškiai creates its own memory narratives and shapes new young people’s identities. While preserving their parents’ and grandparents’ historical experiences as images of the past, and at the same time taking on the local individual corporal identity, young people face a duality of identity. In this situation, the young generation of Vilkyškiai tends to give priority to the locally distinctive cultural identity of Lithuania Minor, calling themselves the inhabitants of this particular land. This permits them to feel distinct and interesting. Meanwhile, their parents’ and ancestors’ historical narratives are most often endorsed as the factor shaping their fundamental moral values.

The association of personal semantic memory to identity representations: insight into higher-order networks of autobiographical contents.

Science.gov (United States)

Grilli, Matthew D

2017-11-01

Identity representations are higher-order knowledge structures that organise autobiographical memories on the basis of personality and role-based themes of one's self-concept. In two experiments, the extent to which different types of personal semantic content are reflected in these higher-order networks of memories was investigated. Healthy, young adult participants generated identity representations that varied in remoteness of formation and verbally reflected on these themes in an open-ended narrative task. The narrative responses were scored for retrieval of episodic, experience-near personal semantic and experience-far (i.e., abstract) personal semantic contents. Results revealed that to reflect on remotely formed identity representations, experience-far personal semantic contents were retrieved more than experience-near personal semantic contents. In contrast, to reflect on recently formed identity representations, experience-near personal semantic contents were retrieved more than experience-far personal semantic contents. Although episodic memory contents were retrieved less than both personal semantic content types to reflect on remotely formed identity representations, this content type was retrieved at a similar frequency as experience-far personal semantic content to reflect on recently formed identity representations. These findings indicate that the association of personal semantic content to identity representations is robust and related to time since acquisition of these knowledge structures.

Latina high school students figured world of STEM: Identity formation in formal and informal communities of practice

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Alcantara, Minosca Victoria

In the United States, the education and skill levels of the American population are not measuring up to the growing demands of the STEM workplace. The Bureau of Labor Statistics (BLS) (2007) projects that over the next 20 years, there will be an estimated shortage of 21 million skilled workers. STEM professions (those in Science, Technology, Engineering, and Mathematics), will continue to lead this workforce growth. However, fewer students are majoring in these areas of critical need, particularly women and minorities. Only a small fraction of U.S.-born scientists and engineers training to fill these positions are members of underrepresented minorities (Latino, Black, and American Indian/Native Alaskan students), yet this same population is expected to experience the greatest growth over the next several decades. Using qualitative methods, I explore the role formal and informal communities of practice play in either motivating or hindering Latinas' interest in STEM career. I use the narratives of 16 low-income, urban Latina high school seniors to provide a counternarrative as to the reasons for these underrepresentation. Teachers in the U.S. play a significant role in the reproduction of the culturally prototypical conception of math and science students; the best and brightest in the school. Teachers' role in positioning Latina students in honors/gifted programs based on their perceptions of students' characteristics and their recommendations for placement in honors classes/ programs, STEM extracurricular activities and summer programs are critical to Latina's "good student" identity formation which has a significant role in their motivation or erasure of STEM identities. Latinas in this study strongly identified with their school and were very concerned in maintaining their good student identities. They defined academic success based on the grades they obtained and the colleges they were accepted into. I propose an identity model, L-STEM which highlight the power

Learning, memory and exploratory similarities in genetically identical cloned dogs.

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Shin, Chi Won; Kim, Geon A; Park, Won Jun; Park, Kwan Yong; Jeon, Jeong Min; Oh, Hyun Ju; Kim, Min Jung; Lee, Byeong Chun

2016-12-30

Somatic cell nuclear transfer allows generation of genetically identical animals using donor cells derived from animals with particular traits. To date, few studies have investigated whether or not these cloned dogs will show identical behavior patterns. To address this question, learning, memory and exploratory patterns were examined using six cloned dogs with identical nuclear genomes. The variance of total incorrect choice number in the Y-maze test among cloned dogs was significantly lower than that of the control dogs. There was also a significant decrease in variance in the level of exploratory activity in the open fields test compared to age-matched control dogs. These results indicate that cloned dogs show similar cognitive and exploratory patterns, suggesting that these behavioral phenotypes are related to the genotypes of the individuals.

National Identity, International Visitors: Narration and Translation of the Taipei 228 Memorial Museum

Directory of Open Access Journals (Sweden)

Chia-Li Chen

2017-03-01

Full Text Available Although many museums nowadays provide multilingual services, translations in museums have not received enough attention from researchers. The issue of how ideology is embedded in museum texts is translated is particularly underresearched. Since museums are often important sites for tourists to learn about a nation, translation plays a pivotal role in mediating how international visitors construct the host nation’s identity. The translation of national identity is even more important when sensitive topics are dealt with, such as exhibitions of the past in memorial museums. This paper takes the Taipei 228 Memorial Museum as a case study to examine how Taiwanese identity is formatted in the Chinese text and reframed in the English translation. The current study found inconsistent historical perspectives embedded in both texts, particularly in the English translation. We argue that, without awareness of ideological assumptions embedded in translations, museums run the risk of sending unintended messages to international visitors.

Chinese Identity in London-An Analysis from the Aspects of Cultural Heritage and Cultural Memory

Institute of Scientific and Technical Information of China (English)

SHEN Ning

2014-01-01

heritage that has been demonstrated as identity . Cultural heritage, therefore, is the stable and uni-form foundation of “who are we”.Furthermore, throughout their daily lives , materials as well as shared experiences living in their memories drive people towards home , from where cultural heritage stems.In a word, to them, Chinese cultural herit-age and cultural memory has lived inside their bodies , instructing and controlling their behaviour , ideas and even emotions , presenting strong identity in appearance .Perhaps , there will be a lot of un-predictable changes in the future , but these traits are not easily changed .Through this discourse , they are building a place in this world .

The effects of attention on perceptual implicit memory.

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Rajaram, S; Srinivas, K; Travers, S

2001-10-01

Reports on the effects of dividing attention at study on subsequent perceptual priming suggest that perceptual priming is generally unaffected by attentional manipulations as long as word identity is processed. We tested this hypothesis in three experiments by using the implicit word fragment completion and word stem completion tasks. Division of attention was instantiated with the Stroop task in order to ensure the processing of word identity even when the participant's attention was directed to a stimulus attribute other than the word itself. Under these conditions, we found that even though perceptual priming was significant, it was significantly reduced in magnitude. A stem cued recall test in Experiment 2 confirmed a more deleterious effect of divided attention on explicit memory. Taken together, our findings delineate the relative contributions of perceptual analysis and attentional processes in mediating perceptual priming on two ubiquitously used tasks of word fragment completion and word stem completion.

Rethinking the memorial in a Black Belt landscape: Planning, memory and identity of African-Americans in Alabama

Directory of Open Access Journals (Sweden)

Marco Giliberti

2013-01-01

Full Text Available Although many old sites are well preserved, many sites of historical and cultural value in the United States are disappearing due to their abandonment. In some cases, the condition of these sites makes restorers’ work very difficult. In other cases, in order to recover blighted local economies, administrations and cultural institutions are adopting strategic spatial plans to attract tourists or accommodate historical theme parks. However, recent scholarly interest in the interaction of history and collective memory has highlighted these sites. Even if the memory of some historical sites is fading quickly, this memory is receiving greater attention than in the past in order to enhance local identity and strengthen the sense of community. This article examines a number of plans and strategies adopted to give shape to the memorial landscape in Alabama, thereby documenting and exploring some key relations between city planning and the commemoration of African-American history.

The MNESIS model: Memory systems and processes, identity and future thinking.

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Eustache, Francis; Viard, Armelle; Desgranges, Béatrice

2016-07-01

The Memory NEo-Structural Inter-Systemic model (MNESIS; Eustache and Desgranges, Neuropsychology Review, 2008) is a macromodel based on neuropsychological data which presents an interactive construction of memory systems and processes. Largely inspired by Tulving's SPI model, MNESIS puts the emphasis on the existence of different memory systems in humans and their reciprocal relations, adding new aspects, such as the episodic buffer proposed by Baddeley. The more integrative comprehension of brain dynamics offered by neuroimaging has contributed to rethinking the existence of memory systems. In the present article, we will argue that understanding the concept of memory by dividing it into systems at the functional level is still valid, but needs to be considered in the light of brain imaging. Here, we reinstate the importance of this division in different memory systems and illustrate, with neuroimaging findings, the links that operate between memory systems in response to task demands that constrain the brain dynamics. During a cognitive task, these memory systems interact transiently to rapidly assemble representations and mobilize functions to propose a flexible and adaptative response. We will concentrate on two memory systems, episodic and semantic memory, and their links with autobiographical memory. More precisely, we will focus on interactions between episodic and semantic memory systems in support of 1) self-identity in healthy aging and in brain pathologies and 2) the concept of the prospective brain during future projection. In conclusion, this MNESIS global framework may help to get a general representation of human memory and its brain implementation with its specific components which are in constant interaction during cognitive processes. Copyright © 2016 Elsevier Ltd. All rights reserved.

Memory, Identity and the Politics of Curriculum Construction in Transition Societies: Rwanda and South Africa

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Weldon, Gail

2009-01-01

A critical question for societies emerging from conflict is what should be done about the traumatic memories of the past. In post-conflict societies political issues of memory and identity are at the same time issues for curriculum construction. Using the examples of post-conflict Rwanda and South Africa, I raise questions about the competing…

PKMzeta maintains 1-day- and 6-day-old long-term object location but not object identity memory in dorsal hippocampus.

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Hardt, Oliver; Migues, Paola V; Hastings, Margaret; Wong, Jacinda; Nader, Karim

2010-06-01

Continuous activity of the atypical protein kinase C isoform M zeta (PKMzeta) is necessary for maintaining long-term memory acquired in aversively or appetitively motivated associative learning tasks, such as active avoidance, aversive taste conditioning, auditory and contextual fear conditioning, radial arm maze, and watermaze. Whether unreinforced, nonassociative memory will also require PKMzeta for long-term maintenance is not known. Using recognition memory for object location and object identity, we found that inactivating PKMzeta in dorsal hippocampus abolishes 1-day and 6-day-old long-term recognition memory for object location, while recognition memory for object identity was not affected by this treatment. Memory for object location persisted for no more than 35 days after training. These results suggest that the dorsal hippocampus mediates long-term memory for where, but not what things have been encountered, and that PKMzeta maintains this type of spatial knowledge as long as the memory exists.

False Memories Lack Perceptual Detail: Evidence from Implicit Word-Stem Completion and Perceptual Identification Tests

Science.gov (United States)

Hicks, J.L.; Starns, J.J.

2005-01-01

We used implicit measures of memory to ascertain whether false memories for critical nonpresented items in the DRM paradigm (Deese, 1959; Roediger & McDermott, 1995) contain structural and perceptual detail. In Experiment 1, we manipulated presentation modality in a visual word-stem-completion task. Critical item priming was significant and…

Reconstruction of phrenic neuron identity in embryonic stem cell-derived motor neurons.

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Machado, Carolina Barcellos; Kanning, Kevin C; Kreis, Patricia; Stevenson, Danielle; Crossley, Martin; Nowak, Magdalena; Iacovino, Michelina; Kyba, Michael; Chambers, David; Blanc, Eric; Lieberam, Ivo

2014-02-01

Air breathing is an essential motor function for vertebrates living on land. The rhythm that drives breathing is generated within the central nervous system and relayed via specialised subsets of spinal motor neurons to muscles that regulate lung volume. In mammals, a key respiratory muscle is the diaphragm, which is innervated by motor neurons in the phrenic nucleus. Remarkably, relatively little is known about how this crucial subtype of motor neuron is generated during embryogenesis. Here, we used direct differentiation of motor neurons from mouse embryonic stem cells as a tool to identify genes that direct phrenic neuron identity. We find that three determinants, Pou3f1, Hoxa5 and Notch, act in combination to promote a phrenic neuron molecular identity. We show that Notch signalling induces Pou3f1 in developing motor neurons in vitro and in vivo. This suggests that the phrenic neuron lineage is established through a local source of Notch ligand at mid-cervical levels. Furthermore, we find that the cadherins Pcdh10, which is regulated by Pou3f1 and Hoxa5, and Cdh10, which is controlled by Pou3f1, are both mediators of like-like clustering of motor neuron cell bodies. This specific Pcdh10/Cdh10 activity might provide the means by which phrenic neurons are assembled into a distinct nucleus. Our study provides a framework for understanding how phrenic neuron identity is conferred and will help to generate this rare and inaccessible yet vital neuronal subtype directly from pluripotent stem cells, thus facilitating subsequent functional investigations.

Differential effects of spaced vs. massed training in long-term object-identity and object-location recognition memory.

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Bello-Medina, Paola C; Sánchez-Carrasco, Livia; González-Ornelas, Nadia R; Jeffery, Kathryn J; Ramírez-Amaya, Víctor

2013-08-01

Here we tested whether the well-known superiority of spaced training over massed training is equally evident in both object identity and object location recognition memory. We trained animals with objects placed in a variable or in a fixed location to produce a location-independent object identity memory or a location-dependent object representation. The training consisted of 5 trials that occurred either on one day (Massed) or over the course of 5 consecutive days (Spaced). The memory test was done in independent groups of animals either 24h or 7 days after the last training trial. In each test the animals were exposed to either a novel object, when trained with the objects in variable locations, or to a familiar object in a novel location, when trained with objects in fixed locations. The difference in time spent exploring the changed versus the familiar objects was used as a measure of recognition memory. For the object-identity-trained animals, spaced training produced clear evidence of recognition memory after both 24h and 7 days, but massed-training animals showed it only after 24h. In contrast, for the object-location-trained animals, recognition memory was evident after both retention intervals and with both training procedures. When objects were placed in variable locations for the two types of training and the test was done with a brand-new location, only the spaced-training animals showed recognition at 24h, but surprisingly, after 7 days, animals trained using both procedures were able to recognize the change, suggesting a post-training consolidation process. We suggest that the two training procedures trigger different neural mechanisms that may differ in the two segregated streams that process object information and that may consolidate differently. Copyright © 2013 Elsevier B.V. All rights reserved.

Contingency blindness: location-identity binding mismatches obscure awareness of spatial contingencies and produce profound interference in visual working memory.

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Fiacconi, Chris M; Milliken, Bruce

2012-08-01

The purpose of the present study was to highlight the role of location-identity binding mismatches in obscuring explicit awareness of a strong contingency. In a spatial-priming procedure, we introduced a high likelihood of location-repeat trials. Experiments 1, 2a, and 2b demonstrated that participants' explicit awareness of this contingency was heavily influenced by the local match in location-identity bindings. In Experiment 3, we sought to determine why location-identity binding mismatches produce such low levels of contingency awareness. Our results suggest that binding mismatches can interfere substantially with visual-memory performance. We attribute the low levels of contingency awareness to participants' inability to remember the critical location-identity binding in the prime on a trial-to-trial basis. These results imply a close interplay between object files and visual working memory.

A Bridge to the Stars: A Model High School-to-College Pipeline for Encouraging Positive STEM Identities

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McIntosh, Daniel H.; Jennings, Derrick H.

2018-01-01

The need to grow and diversify the STEM workforce remains a critical national challenge. Research shows that STEM identity (how one views herself/himself with respect to STEM) is an important factor for success or failure. A Bridge to the Stars (ABttS) offers URM and low-income high-school students a high impact exposure to science through innovative experiential learning with a professional scientist in freshmen astronomy at UMKC, an urban research university. Showing students who traditionally do not self-identify with high-tech careers that they can succeed in a university science course is a promising way to help build positive STEM identities and aspirations during the critical bridge between high school and college. In five years, we have awarded 45 ABttS scholarships; 93% of these 15-17 year-old students have passed the course satisfactorily with an average grade of 80%. Remarkably, the ABttS scholar performance is on par with that of 600 UMKC students enrolled in the same courses over 8 semesters. Long-term tracking of former scholars shows positive attitudes regarding ABttS and persistence in STEM aspirations at promising rates based on small-number statistics. I will describe the implementation of this unique STEM immersion program offering extended and inclusive engagement in astronomy, arguably the most accessible window to science. I will share classroom and near-peer mentoring innovations, and a new third ABttS tier in which previous scholars can enroll in a freshmen science laboratory experience for UMKC credit. This novel course introduces novices to scientific research and Big Data science through authentic hands-on experiences centered on their own exploration of data from McIntosh's actual research. The long-term mission of ABttS is to see urban educational institutions across the U.S. adopt similar pipelines in all STEM disciplines built on the ABttS model. Adopting programs like ABttS for freshmen STEM majors, especially in urban colleges and

A Temporal Perspective on Organizational Identity

DEFF Research Database (Denmark)

Schultz, Majken; Hernes, Tor

2013-01-01

time perspective in the use of memory enabled a longer time perspective in formulating claims for future identity, (2) a broader scope of articulated identity claims for the future was related to the combination of a broader range of memory forms, and (3) the depth of claims for future identity...... was related to the way in which memory forms were combined. At a more general level, our paper illustrates how viewing identity construction from the perspective of an ongoing present adds a new dimension to understanding the temporal dynamics of organizational identity....

Einstein girls: Exploring STEM careers, interest, and identity in an online mentoring community

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Scott, Jill Rice

The purpose of this project was to create and study an online mentoring community that connected fifth and sixth grade girls and female STEM mentors. The project was designed to give girls who were interested in science the chance to communicate online with women who were successful STEM professionals. The community provided the girls a venue to ask the women questions about their careers, their interests, and their science identities. Through this venue the girls were able to explore various STEM careers, be exposed to role models, and potentially increase their interest in science for the future. Mentoring has been shown to have a positive impact on girls and help improve their attitudes toward science and interests in STEM. The project examined the nature of the online mentoring process as well as the participants' perceptions of the opportunities and constraints of the community. The girls were members of an afterschool academy and the mentoring took place through the Internet using a secure educational social networking program. The program spanned a four-week period between April and May 2013. The main purpose of this study was formative since online mentoring is a relatively new area of research. This investigation produced detailed accounts of activities between the girls and the mentors. Findings revealed that the participants approached the community uniquely and explored many aspects of career exploration, STEM interest, and science identity. The participants also identified what they perceived as the opportunities afforded by the community as well as the constraints posed by the community. The research represented by this study was practitioner research with the work connecting theory with practice. The knowledge gained through the intentional reflection on and study of the Einstein Girls online mentoring community was useful in the production of knowledge that is transformative for the researcher's professional practice and transferable to other

MicroRNA-21 preserves the fibrotic mechanical memory of mesenchymal stem cells.

Science.gov (United States)

Li, Chen Xi; Talele, Nilesh P; Boo, Stellar; Koehler, Anne; Knee-Walden, Ericka; Balestrini, Jenna L; Speight, Pam; Kapus, Andras; Hinz, Boris

2017-03-01

Expansion on stiff culture substrates activates pro-fibrotic cell programs that are retained by mechanical memory. Here, we show that priming on physiologically soft silicone substrates suppresses fibrogenesis and desensitizes mesenchymal stem cells (MSCs) against subsequent mechanical activation in vitro and in vivo, and identify the microRNA miR-21 as a long-term memory keeper of the fibrogenic program in MSCs. During stiff priming, miR-21 levels were gradually increased by continued regulation through the acutely mechanosensitive myocardin-related transcription factor-A (MRTF-A/MLK-1) and remained high over 2 weeks after removal of the mechanical stimulus. Knocking down miR-21 once by the end of the stiff-priming period was sufficient to erase the mechanical memory and sensitize MSCs to subsequent exposure to soft substrates. Soft priming and erasing mechanical memory following cell culture expansion protects MSCs from fibrogenesis in the host wound environment and increases the chances for success of MSC therapy in tissue-repair applications.

Contralateral delay activity tracks object identity information in visual short term memory.

Science.gov (United States)

Gao, Zaifeng; Xu, Xiaotian; Chen, Zhibo; Yin, Jun; Shen, Mowei; Shui, Rende

2011-08-11

Previous studies suggested that ERP component contralateral delay activity (CDA) tracks the number of objects containing identity information stored in visual short term memory (VSTM). Later MEG and fMRI studies implied that its neural source lays in superior IPS. However, since the memorized stimuli in previous studies were displayed in distinct spatial locations, hence possibly CDA tracks the object-location information instead. Moreover, a recent study implied the activation in superior IPS reflected the location load. The current research thus explored whether CDA tracks the object-location load or the object-identity load, and its neural sources. Participants were asked to remember one color, four identical colors or four distinct colors. The four-identical-color condition was the critical one because it contains the same amount of identity information as that of one color while the same amount of location information as that of four distinct colors. To ensure the participants indeed selected four colors in the four-identical-color condition, we also split the participants into two groups (low- vs. high-capacity), analyzed late positive component (LPC) in the prefrontal area, and collected participant's subjective-report. Our results revealed that most of the participants selected four identical colors. Moreover, regardless of capacity-group, there was no difference on CDA between one color and four identical colors yet both were lower than 4 distinct colors. Besides, the source of CDA was located in the superior parietal lobule, which is very close to the superior IPS. These results support the statement that CDA tracks the object identity information in VSTM. Copyright © 2011 Elsevier B.V. All rights reserved.

Understanding the Relationship Between Parental Education and STEM Course Taking Through Identity-Based and Expectancy-Value Theories of Motivation

Directory of Open Access Journals (Sweden)

Ryan C. Svoboda

2016-08-01

Full Text Available High school students from lower–socioeconomic status (SES backgrounds are less likely to enroll in advanced mathematics and science courses compared to students from higher-SES backgrounds. The current longitudinal study draws on identity-based and expectancy-value theories of motivation to explain the SES and mathematics and science course-taking relationship. This was done by gathering reports from students and their parents about their expectations, values, and future identities for science, technology, engineering, and mathematics (STEM topics beginning in middle school through age 20. Results showed that parental education predicted mathematics and science course taking in high school and college, and this relationship was partially mediated by students’ and parents’ future identity and motivational beliefs concerning mathematics and science. These findings suggest that psychological interventions may be useful for reducing social class gaps in STEM course taking, which has critical implications for the types of opportunities and careers available to students.

A short CD3/CD28 costimulation combined with IL-21 enhance the generation of human memory stem T cells for adoptive immunotherapy.

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Alvarez-Fernández, C; Escribà-Garcia, L; Vidal, S; Sierra, J; Briones, J

2016-07-19

Immunotherapy based on the adoptive transfer of gene modified T cells is an emerging approach for the induction of tumor-specific immune responses. Memory stem T cells, due to their enhanced antitumor and self-renewal capacity, have become potential candidate for adoptive T cell therapy of cancer. Methods to generate memory stem T cells ex vivo rely on CD3/CD28 costimulation and the use of cytokines such as IL-7 and IL-15 during the entire culture period. However, a strong costimulation may induce differentiation of memory stem T cells to effector memory T cells. Here we show that manipulation of the length of the costimulation and addition of IL-21 enhance the ex vivo expansion of memory stem T cells. Purified naïve T cells from healthy donors were cultured in the presence of anti-CD3/CD28 coated beads, IL-7, IL-15 and/or IL-21 (25 ng/ml). T cells phenotype from the different memory and effector subpopulations were analyzed by multiparametric flow cytometry. A short anti-CD3/CD28 costimulation of naïve T cells, combined with IL-7 and IL-15 significantly increased the frequencies of CD4(+) and CD8(+) memory stem T cells ex vivo, compared to a prolonged costimulation (34.6 ± 4.4 % vs 15.6 ± 4.24 % in CD4(+); p = 0.008, and 20.5 ± 4.00 % vs 7.7 ± 2.53 % in CD8(+); p = 0.02). Moreover, the addition of IL-21 to this condition further enhanced the enrichment and expansion of CD4(+) and CD8(+) memory stem T cells with an increase in the absolute numbers (0.7 × 10(6) ± 0.1 vs 0.26 × 10(6) ± 0.1 cells for CD4(+); p = 0.002 and 1.1 × 10(6) ± 0.1 vs 0.27 × 10(6) ± 0.1 cells for CD8(+); p = 0.0002; short + IL-21 vs long). These new in vitro conditions increase the frequencies and expansion of memory stem T cells and may have relevant clinical implications for the generation of this memory T cell subset for adoptive cell therapy of patients with cancer.

The Impact of an Authentic Science Experience on STEM Identity: A Preliminary Analysis of YouthAstroNet and MicroObservatory Telescope Network Participant Data

Science.gov (United States)

Dussault, Mary E.; Wright, Erika A.; Sadler, Philip; Sonnert, Gerhard; ITEAMS II Team

2018-01-01

Encouraging students to pursue careers in science, technology, engineering, and mathematics (STEM) is a high priority for national K-12 education improvement initiatives in the United States. Many educators have claimed that a promising strategy for nurturing early student interest in STEM is to engage them in authentic inquiry experiences. “Authentic” refers to investigations in which the questions are of genuine interest and importance to students, and the inquiry more closely resembles the way real science is done. Science education researchers and practitioners at the Harvard-Smithsonian Center for Astrophysics have put this theory into action with the development of YouthAstroNet, a nationwide online learning community of middle-school aged students, educators, and STEM professionals that features the MicroObservatory Robotic Telescope Network, professional image analysis software, and complementary curricula for use in a variety of learning settings. This preliminary study examines factors that influence YouthAstroNet participants' Science Affinity, STEM Identity, and STEM Career Interest, using the matched pre/post survey results of 261 participants as the data source. The pre/post surveys included some 40 items measuring affinity, identity, knowledge, and career interest. In addition, the post intervention instrument included a number of items in which students reported the instructional strategies they experienced as part of the program. A simple analysis of pre-post changes in affinity and interest revealed very little significant change, and for those items where a small pre-post effect was observed, the average change was most often negative. However, after accounting for students' different program treatment experiences and for their prior attitudes and interests, a predictor of significant student gains in Affinity, STEM Identity, Computer/Math Identity, and STEM Career Interest could be identified. This was the degree to which students reported

Gender identity better than sex explains individual differences in episodic and semantic components of autobiographical memory and future thinking.

Science.gov (United States)

Compère, Laurie; Rari, Eirini; Gallarda, Thierry; Assens, Adèle; Nys, Marion; Coussinoux, Sandrine; Machefaux, Sébastien; Piolino, Pascale

2018-01-01

A recently tested hypothesis suggests that inter-individual differences in episodic autobiographical memory (EAM) are better explained by individual identification of typical features of a gender identity than by sex. This study aimed to test this hypothesis by investigating sex and gender related differences not only in EAM but also during retrieval of more abstract self-knowledge (i.e., semantic autobiographical memory, SAM, and conceptual self, CS), and considering past and future perspectives. No sex-related differences were identified, but regardless of the sex, feminine gender identity was associated with clear differences in emotional aspects that were expressed in both episodic and more abstract forms of AM, and in the past and future perspectives, while masculine gender identity was associated with limited effects. In conclusion, our results support the hypothesis that inter-individual differences in AM are better explained by gender identity than by sex, extending this assumption to both episodic and semantic forms of AM and future thinking. Copyright © 2017 Elsevier Inc. All rights reserved.

Memory Age Identity as a predictor of cognitive function in the elderly: A 2-year follow-up study.

Science.gov (United States)

Chang, Ki Jung; Hong, Chang Hyung; Lee, Yun Hwan; Chung, Young Ki; Lim, Ki Young; Noh, Jai Sung; Kim, Jin-Ju; Kim, Haena; Kim, Hyun-Chung; Son, Sang Joon

2018-01-01

There is a growing interest in finding psychosocial predictors related to cognitive function. In our previous research, we conducted a cross-sectional study on memory age identity (MAI) and found that MAI might be associated with objective cognitive performance in non-cognitively impaired elderly. A longitudinal study was conducted to better understand the importance of MAI as a psychosocial predictor related to objective cognitive function. Data obtained from 1345 Korean subjects aged 60 years and above were analyzed. During the two-year follow-up, subjective memory age was assessed on three occasions using the following question: How old do you feel based on your memory? Discrepancy between subjective memory age and chronological age was then calculated. We defined this value as 'memory age identity (MAI)'. A generalized estimating equation (GEE) was then obtained to demonstrate the relationship between MAI and Korean version-Mini Mental State Examination (K-MMSE) score over the 2 years of study. MAI was found to significantly (β=-0.03, p< 0.0001) predict objective cognitive performance in the non-cognitively impaired elderly. MAI may be a potential psychosocial predictor related to objective cognitive performance in the non-cognitively impaired elderly. Copyright © 2017 Elsevier B.V. All rights reserved.

Survivorship and discourses of identity.

Science.gov (United States)

Little, Miles; Paul, Kim; Jordens, Christopher F C; Sayers, Emma-Jane

2002-01-01

Personal identity is self-evidently important to us all. Identity is a philosophically complex subject, but there is some agreement that memory, embodiment and continuity are essential components. The sense of memory includes 'future memory', the kind of memory we would like to construct for ourselves as our lives proceed. While the sense of personal identity is internal to the individual, a sense of that person's identity exists in the minds of others. Extreme experiences threaten the element of continuity, because they may bring bodily changes as well as cognitive changes that challenge central values. Restoring or preserving continuity is a major task for survivors. The ways in which people experience discontinuity because of cancer illness, and the ways in which they manage this experience emerges from the narratives of the survivors of cancer and in the narratives of health care workers who look after them. People manage discontinuity by reference to stable 'anchor points' in their beliefs and values; by re-constructing versions of their pre-experience identities, drawing on past memory and finding ways to preserve a continuity between past memory, present experience and constructions of the future; by using the experience to develop established facets of identity; and by imbuing the experience with meaning and recognising the enlarged identity made possible by survival. Those who cannot achieve a sense of continuity may feel alienated from themselves, their friends and family. All these methods of management may be used by one person to negotiate the post-experience identity in its different social interactions. The experience of the survivor can be further understood by recognising the challenge posed by extreme experience to the sense of continuity of both embodied self and memory. A satisfactory discourse of survival has yet to enter the public domain. This lack adds to the burdens of survivors, including those who have survived cancer. Copyright 2002 John

Cued Recall from Image and Sentence Memory: A Shift from Episodic to Identical Elements Representation

Science.gov (United States)

Rickard, Timothy C.; Bajic, Daniel

2006-01-01

The applicability of the identical elements (IE) model of arithmetic fact retrieval (T. C. Rickard, A. F. Healy, & L. E. Bourne, 1994) to cued recall from episodic (image and sentence) memory was explored in 3 transfer experiments. In agreement with results from arithmetic, speedup following even minimal practice recalling a missing word from an…

Stem cells

NARCIS (Netherlands)

Jukes, Jojanneke; Both, Sanne; Post, Janine; van Blitterswijk, Clemens; Karperien, Marcel; de Boer, Jan; van Blitterswijk, Clemens A.

2008-01-01

This chapter defines stem cells and their properties. It identifies the major differences between embryonic and adult stem cells. Stem cells can be defined by two properties: the ability to make identical copies of themselves and the ability to form other cell types of the body. These properties are

Irish Intercultural Cinema: Memory, Identity and Subjectivity

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Murray, Enda Vincent

2015-12-01

Full Text Available Irish intercultural cinema looks at the development of a cinematic genre which focuses on issues of Irish migrancy but is produced outside of Ireland. This paper has as its focus the cultural landscape of Irish-Australia. The essay uses methodologies of ethnographic and documentary theory plus textual analysis of film and written texts to establish a throughline of Irish intercultural film. The essay begins by contextualising the place of the Irish diaspora within the creation of Irish identity globally. The discussion around migrancy is widened to consider the place of memory and intergenerational tensions within not just the Irish migrant population, but also within the diverse cultures which comprise the contemporary Australian landscape. The historical development of intercultural cinema is then explored internationally within a context of colonial, gender and class struggles in the 1970s and1980s. The term intercultural cinema has its origins in the Third Cinema of Argentinians Solanas and Getino in the 1970s and covers those films which deal with issues involving two countries or cultures. The term was refined by Laura Marks in 2000 and further developed by Hamid Naficy in 2001 in his discussion of accented cinema which narrows its definition to include the politics of production. The paper then traces the development of Irish intercultural cinema from its beginnings in England in the 1970s with Thaddeus O'Sullivan through to Nicola Bruce and others including Enda Murray in the present day. The essay concludes by bringing these various strands together to see where intercultural film might have a place in today's globalised cultural landscape. Common traits within intercultural film such as the notion of place, autobiographical film and personal identity are explored using examples of intercultural filmmaking from around the globe. These commonalities point to a way forward for the future of a sustainable multicultural film culture.

Inter-identity autobiographical amnesia in patients with dissociative identity disorder.

Science.gov (United States)

Huntjens, Rafaële J C; Verschuere, Bruno; McNally, Richard J

2012-01-01

A major symptom of Dissociative Identity Disorder (DID; formerly Multiple Personality Disorder) is dissociative amnesia, the inability to recall important personal information. Only two case studies have directly addressed autobiographical memory in DID. Both provided evidence suggestive of dissociative amnesia. The aim of the current study was to objectively assess transfer of autobiographical information between identities in a larger sample of DID patients. Using a concealed information task, we assessed recognition of autobiographical details in an amnesic identity. Eleven DID patients, 27 normal controls, and 23 controls simulating DID participated. Controls and simulators were matched to patients on age, education level, and type of autobiographical memory tested. Although patients subjectively reported amnesia for the autobiographical details included in the task, the results indicated transfer of information between identities. The results call for a revision of the DID definition. The amnesia criterion should be modified to emphasize its subjective nature.

Self-reference effect on memory in healthy aging, mild cognitive impairment and Alzheimer's disease: Influence of identity valence.

Science.gov (United States)

Leblond, Mona; Laisney, Mickaël; Lamidey, Virginie; Egret, Stéphanie; de La Sayette, Vincent; Chételat, Gaël; Piolino, Pascale; Rauchs, Géraldine; Desgranges, Béatrice; Eustache, Francis

2016-01-01

The self-reference effect (SRE) has been shown to benefit episodic memory in healthy individuals. In healthy aging, its preservation is acknowledged, but in Alzheimer's disease (AD), the jury is still out. Furthermore, there has yet to be a study of the SRE in amnestic mild cognitive impairment (aMCI). As self-reference implies subjective self-representations, and positive information enhance memory performance, we set out to examine the effects of 1) material and 2) identity valence on the SRE across the early stages of AD. Twenty healthy older individuals and 40 patients (20 diagnosed with aMCI and 20 diagnosed with mild AD) performed a memory task. Participants had to judge positive and negative personality trait adjectives with reference to themselves or to another person, or else process these adjectives semantically. We then administered a recognition task. Participants also completed a questionnaire on identity valence. Among healthy older individuals, the SRE benefited episodic memory independently of material and identity valence. By contrast, among aMCI patients, we only observed the SRE when the material was positive. When self-referential material was negative, patients' performance depended on the valence of their self-representations: negative self-representations correlated with poor recognition of negative self-referential adjectives. Finally, performance of patients with mild AD by condition and material valence were too low and inappropriate to be subjected to relevant analyses. The persistence of an SRE for positive adjectives in aMCI suggests the existence of a positivity effect for self-related information, which contributes to wellbeing. The absence of an SRE for negative adjectives, which led aMCI patients to dismiss negative self-related information, could be due to low self-esteem. These results corroborate the mnenic neglect model and point out the importance of the psychoaffective dimension in patients with aMCI, which could constitute a

Memories and identities redefinitions around the independence process in Cape Verde. The case of the Argentine-Cape Verdeans from Buenos Aires

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Maria Cecilia Martino

2017-12-01

Full Text Available The article analyzes, from an ethnographic and historical perspective, the relations between memory, identity and Afro-descendant political activism among the Argentine-Cape Verdeans from Buenos Aires. The article highlights the memories and stories of the independence of Cape Verde, and the role played in it by Amílcar Cabral, the main political leader of this process. These narratives, whose specific expression are reflected in the institutional space of the Cape Verdean Society of Dock Sud, are updated from different perspectives and redefine the changing identity borders that allow the delineation of specific forms of political activism in Buenos Aires.

Memoria collettiva e identità etnica degli Herero nella Namibia post-coloniale: pratiche cerimoniali, paesaggi della memoria e “variazioni” di confine - Collective memory and ethnic identity of the Herrero in post-colonial Namibia: cerimonial practices, memory landscapes and border “variations”

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Chiara Brambilla

2013-12-01

Full Text Available This article proposes a reflection on two founding dimensions of social and cultural life: memory and identity. Such a reflection particularly focuses on the relationship that memory and identity maintain with places and landscape. Among material and symbolic places where the link between memory and identity can be critically understood, this article will refer to boundaries. Not only is this about territorial boundaries and the exercise of the sovereign authority, but it also regards boundaries taken as ethnic, socio-cultural, and symbolic entities expressing social categorizations that can be referred to the changing politics of identity. Within this framework, this essay examines the relationship between collective memory and ethnic identity of the Hereros within the contemporary post-colonial Namibian scenario. Such a relationship will be explained by describing multiple “variations” of ethnic and socio-cultural boundaries that are territorialized through different memory strategies in the Namibian landscape. The territorialization of the Herero memory is linked to the experience of the colonial war between the Hereros and the German colonial troops from 1904 to 1908; to the diaspora of the Hereros due to the colonial conflict with the Germans; and to the German construction of concentration camps for the Herero prisoners between 1904 and 1908 throughout Namibia. This way, the issues in the heart of the territorialization of the Herero memory are strictly connected with the “genocide” of these people. In this light, the Herero memory can be considered as a tool for creating a contemporary representation of social and political unity of the Herero group that is legitimated by various commemorative practices and rituals held in different areas of Namibia and organized by a ritual and social network established in the aftermath of the colonial war. At the same time these commemorative rituals contribute to allow the Hereros to resist

Monitoring cell line identity in collections of human induced pluripotent stem cells

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Raquel Sarafian

2018-04-01

Full Text Available The ability to reprogram somatic cells into induced pluripotent stem cells (hiPSCs has led to the generation of large collections of cell lines from thousands of individuals with specific phenotypes, many of which will be shared among different research groups as invaluable tools for biomedical research. As hiPSC-based research involves extensive culture of many cell lines, the issue periodic cell line identification is particularly important to ensure that cell line identity remains accurate. Here we analyzed the different commercially available genotyping methods considering ease of in-house genotyping, cost and informativeness, and applied one of them in our workflow for hiPSC generation. We show that the chosen STR method was able to establish a unique DNA profile for each of the 35 individuals/hiPSC lines at the examined sites, as well as identify two discrepancies resulting from inadvertently exchanged samples. Our results highlight the importance of hiPSC line genotyping by an in-house method that allows periodic cell line identification and demonstrate that STR is a useful approach to supplement less frequent karyotyping and epigenetic evaluations. Keywords: Induced pluripotent stem cells, Genotyping, Cell line identification, Short tandem repeats, Quality control

Tethered IL-15 augments antitumor activity and promotes a stem-cell memory subset in tumor-specific T cells.

Science.gov (United States)

Hurton, Lenka V; Singh, Harjeet; Najjar, Amer M; Switzer, Kirsten C; Mi, Tiejuan; Maiti, Sourindra; Olivares, Simon; Rabinovich, Brian; Huls, Helen; Forget, Marie-Andrée; Datar, Vrushali; Kebriaei, Partow; Lee, Dean A; Champlin, Richard E; Cooper, Laurence J N

2016-11-29

Adoptive immunotherapy retargeting T cells to CD19 via a chimeric antigen receptor (CAR) is an investigational treatment capable of inducing complete tumor regression of B-cell malignancies when there is sustained survival of infused cells. T-memory stem cells (T SCM ) retain superior potential for long-lived persistence, but challenges exist in manufacturing this T-cell subset because they are rare among circulating lymphocytes. We report a clinically relevant approach to generating CAR + T cells with preserved T SCM potential using the Sleeping Beauty platform. Because IL-15 is fundamental to T-cell memory, we incorporated its costimulatory properties by coexpressing CAR with a membrane-bound chimeric IL-15 (mbIL15). The mbIL15-CAR T cells signaled through signal transducer and activator of transcription 5 to yield improved T-cell persistence independent of CAR signaling, without apparent autonomous growth or transformation, and achieved potent rejection of CD19 + leukemia. Long-lived T cells were CD45RO neg CCR7 + CD95 + , phenotypically most similar to T SCM , and possessed a memory-like transcriptional profile. Overall, these results demonstrate that CAR + T cells can develop long-term persistence with a memory stem-cell phenotype sustained by signaling through mbIL15. This observation warrants evaluation in clinical trials.

Inter-Identity Autobiographical Amnesia in Patients with Dissociative Identity Disorder

Science.gov (United States)

Huntjens, Rafaële J. C.; Verschuere, Bruno; McNally, Richard J.

2012-01-01

Background A major symptom of Dissociative Identity Disorder (DID; formerly Multiple Personality Disorder) is dissociative amnesia, the inability to recall important personal information. Only two case studies have directly addressed autobiographical memory in DID. Both provided evidence suggestive of dissociative amnesia. The aim of the current study was to objectively assess transfer of autobiographical information between identities in a larger sample of DID patients. Methods Using a concealed information task, we assessed recognition of autobiographical details in an amnesic identity. Eleven DID patients, 27 normal controls, and 23 controls simulating DID participated. Controls and simulators were matched to patients on age, education level, and type of autobiographical memory tested. Findings Although patients subjectively reported amnesia for the autobiographical details included in the task, the results indicated transfer of information between identities. Conclusion The results call for a revision of the DID definition. The amnesia criterion should be modified to emphasize its subjective nature. PMID:22815769

Inter-identity autobiographical amnesia in patients with dissociative identity disorder.

Directory of Open Access Journals (Sweden)

Rafaële J C Huntjens

Full Text Available BACKGROUND: A major symptom of Dissociative Identity Disorder (DID; formerly Multiple Personality Disorder is dissociative amnesia, the inability to recall important personal information. Only two case studies have directly addressed autobiographical memory in DID. Both provided evidence suggestive of dissociative amnesia. The aim of the current study was to objectively assess transfer of autobiographical information between identities in a larger sample of DID patients. METHODS: Using a concealed information task, we assessed recognition of autobiographical details in an amnesic identity. Eleven DID patients, 27 normal controls, and 23 controls simulating DID participated. Controls and simulators were matched to patients on age, education level, and type of autobiographical memory tested. FINDINGS: Although patients subjectively reported amnesia for the autobiographical details included in the task, the results indicated transfer of information between identities. CONCLUSION: The results call for a revision of the DID definition. The amnesia criterion should be modified to emphasize its subjective nature.

Gender-, Race-, and Income-Based Stereotype Threat: The Effects of Multiple Stigmatized Aspects of Identity on Math Performance and Working Memory Function

Science.gov (United States)

Tine, Michele; Gotlieb, Rebecca

2013-01-01

This study compared the relative impact of gender-, race-, and income-based stereotype threat and examined if individuals with multiple stigmatized aspects of identity experience a larger stereotype threat effect on math performance and working memory function than people with one stigmatized aspect of identity. Seventy-one college students of the…

PEG IS 40!: place, community, identity, memory and myth in the Dandenong Ranges

OpenAIRE

Dyson, Brydie Shae

2017-01-01

PEG IS 40! investigates memory, myth and storytelling as well as personal and communal identity with a sense of place, focusing on a particular site, that of the PEG IS 40! inscription on the train bridge in Upper Femtree Gully above Burwood Highway. The text there has not been weathered away, further graffiti has not overwritten it, and it has not been removed by council. In this time of rapid cultural transformation and global pressures, Peg is still and has always been 40. There is a certa...

Pluripotency transcription factors and Tet1/2 maintain Brd4-independent stem cell identity.

Science.gov (United States)

Finley, Lydia W S; Vardhana, Santosha A; Carey, Bryce W; Alonso-Curbelo, Direna; Koche, Richard; Chen, Yanyang; Wen, Duancheng; King, Bryan; Radler, Megan R; Rafii, Shahin; Lowe, Scott W; Allis, C David; Thompson, Craig B

2018-05-01

A robust network of transcription factors and an open chromatin landscape are hallmarks of the naive pluripotent state. Recently, the acetyllysine reader Brd4 has been implicated in stem cell maintenance, but the relative contribution of Brd4 to pluripotency remains unclear. Here, we show that Brd4 is dispensable for self-renewal and pluripotency of embryonic stem cells (ESCs). When maintained in their ground state, ESCs retain transcription factor binding and chromatin accessibility independent of Brd4 function or expression. In metastable ESCs, Brd4 independence can be achieved by increased expression of pluripotency transcription factors, including STAT3, Nanog or Klf4, so long as the DNA methylcytosine oxidases Tet1 and Tet2 are present. These data reveal that Brd4 is not essential for ESC self-renewal. Rather, the levels of pluripotency transcription factor abundance and Tet1/2 function determine the extent to which bromodomain recognition of protein acetylation contributes to the maintenance of gene expression and cell identity.

The role of involuntary aware memory in the implicit stem and fragment completion tasks: a selective review.

Science.gov (United States)

Kinoshita, S

2001-03-01

In this article I argue that an awareness of the study episode that arises involuntarily during an implicit stem/fragment completion test can under some conditions lead to enhanced repetition priming effects, even though subjects are not engaged in intentional retrieval. I review findings that are consistent with this possibility, which include the effects of depth of processing, and of typography match and new association priming following deep encoding. A theoretical account of involuntary aware memory couched within Moscovitch's (1995b) memory systems framework which suggests that the medial-temporal lobe/hippocampal (MTL/H) complex functions as a memory module is outlined. A putative mechanism is proposed in which involuntary aware memory of a studied item enhances the size of repetition priming effects by guiding its selection in preference to the competitors.

Psychobiological characteristics of dissociative identity disorder: a symptom provocation study.

Science.gov (United States)

Reinders, A A T Simone; Nijenhuis, Ellert R S; Quak, Jacqueline; Korf, Jakob; Haaksma, Jaap; Paans, Anne M J; Willemsen, Antoon T M; den Boer, Johan A

2006-10-01

Dissociative identity disorder (DID) patients function as two or more identities or dissociative identity states (DIS), categorized as 'neutral identity states' (NIS) and 'traumatic identity states' (TIS). NIS inhibit access to traumatic memories thereby enabling daily life functioning. TIS have access and responses to these memories. We tested whether these DIS show different psychobiological reactions to trauma-related memory. A symptom provocation paradigm with 11 DID patients was used in a two-by-two factorial design setting. Both NIS and TIS were exposed to a neutral and a trauma-related memory script. Three psychobiological parameters were tested: subjective ratings (emotional and sensori-motor), cardiovascular responses (heart rate, blood pressure, heart rate variability) and regional cerebral blood flow as determined with H(2)(15)O positron emission tomography. Psychobiological differences were found for the different DIS. Subjective and cardiovascular reactions revealed significant main and interactions effects. Regional cerebral blood flow data revealed different neural networks to be associated with different processing of the neutral and trauma-related memory script by NIS and TIS. Patients with DID encompass at least two different DIS. These identities involve different subjective reactions, cardiovascular responses and cerebral activation patterns to a trauma-related memory script.

Mesenchymal Stem Cells Preserve Working Memory in the 3xTg-AD Mouse Model of Alzheimer's Disease

Czech Academy of Sciences Publication Activity Database

Růžička, Jiří; Kulijewicz-Nawrot, Magdaléna; Rodrigez-Arellano, Jose Julio; Jendelová, Pavla; Syková, Eva

2016-01-01

Roč. 17, č. 2 (2016), FEB 2016 ISSN 1661-6596 R&D Projects: GA ČR(CZ) GAP304/11/0184; GA ČR(CZ) GBP304/12/G069 Institutional support: RVO:68378041 Keywords : Alzheimer's disease * mesenchymal stem cells * working memory Subject RIV: ED - Physiology

Not always a nerd: exploring the diversity in professional identity profiles of STEM students in relation to their career choices

NARCIS (Netherlands)

Endedijk, M.D.; van Veelen, R.; Möwes, Randy

2017-01-01

Although there is a high demand of highly educated professionals in the technical sector, only about 50% of the graduates from a study program in science, technology, engineering and mathematics (STEM) opt for a career in the technical sector. Professional identity has been shown to influence

Cross-modal and intra-modal binding between identity and location in spatial working memory: The identity of objects does not help recalling their locations.

Science.gov (United States)

Del Gatto, Claudia; Brunetti, Riccardo; Delogu, Franco

2016-01-01

In this study we tested incidental feature-to-location binding in a spatial task, both in unimodal and cross-modal conditions. In Experiment 1 we administered a computerised version of the Corsi Block-Tapping Task (CBTT) in three different conditions: the first one analogous to the original CBTT test; the second one in which locations were associated with unfamiliar images; the third one in which locations were associated with non-verbal sounds. Results showed no effect on performance by the addition of identity information. In Experiment 2, locations on the screen were associated with pitched sounds in two different conditions: one in which different pitches were randomly associated with locations and the other in which pitches were assigned to match the vertical position of the CBTT squares congruently with their frequencies. In Experiment 2 we found marginal evidence of a pitch facilitation effect in the spatial memory task. We ran a third experiment to test the same conditions of Experiment 2 with a within-subject design. Results of Experiment 3 did not confirm the pitch-location facilitation effect. We concluded that the identity of objects does not affect recalling their locations. We discuss our results within the framework of the debate about the mechanisms of "what" and "where" feature binding in working memory.

A memory efficient method for fully three-dimensional object reconstruction with HAADF STEM

International Nuclear Information System (INIS)

Van den Broek, W.; Rosenauer, A.; Van Aert, S.; Sijbers, J.; Van Dyck, D.

2014-01-01

The conventional approach to object reconstruction through electron tomography is to reduce the three-dimensional problem to a series of independent two-dimensional slice-by-slice reconstructions. However, at atomic resolution the image of a single atom extends over many such slices and incorporating this image as prior knowledge in tomography or depth sectioning therefore requires a fully three-dimensional treatment. Unfortunately, the size of the three-dimensional projection operator scales highly unfavorably with object size and readily exceeds the available computer memory. In this paper, it is shown that for incoherent image formation the memory requirement can be reduced to the fundamental lower limit of the object size, both for tomography and depth sectioning. Furthermore, it is shown through multislice calculations that high angle annular dark field scanning transmission electron microscopy can be sufficiently incoherent for the reconstruction of single element nanocrystals, but that dynamical diffraction effects can cause classification problems if more than one element is present. - Highlights: • The full 3D approach to atomic resolution object retrieval has high memory load. • For incoherent imaging the projection process is a matrix–vector product. • Carrying out this product implicitly as Fourier transforms reduces memory load. • Reconstructions are demonstrated from HAADF STEM and depth sectioning simulations

Stem cells and the evolving notion of cellular identity

OpenAIRE

Daley, George Q.

2015-01-01

Stem cells are but one class of the myriad types of cells within an organism. With potential to self-renew and capacity to differentiate, stem cells play essential roles at multiple stages of development. In the early embryo, pluripotent stem cells represent progenitors for all tissues while later in development, tissue-restricted stem cells give rise to cells with highly specialized functions. As best understood in the blood, skin and gut, stem cells are the seeds that sustain tissue homeost...

Memory of the Present: Empathy and Identity in Young Adult Fiction

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Maria Nikolajeva

2014-11-01

Full Text Available Recent studies in cognitive literary criticism have provided scholars of literature with new, stimulating approaches to literary texts and neuroscientists with new insights about human emotions, empathy, and memory through evidence from fiction. What have so far been largely neglected are the implications of cognitive criticism for the study of literature targeting a young audience, whose theory of mind and empathic skills are not yet fully developed. A cognitive approach to children's and young adult literature has to meet several challenges less relevant in general fiction. Firstly, how is a young fictional character's consciousness represented by an author whose cognitive and affective skills are ostensibly superior? Secondly, how do texts instruct their young readers to employ theory of mind in order to assess both the young protagonist's emotions and their understanding of other characters' emotions (higher-order mind-reading? Thirdly, how can fiction support young people's development of their theory of mind? The paper will discuss these issues with a particular focus on memory and identity, expressed textually through tense and narrative perspective. Drawing on work by Lisa Zunshine (2006 and Blackey Vermeule (2010, the predominantly theoretical argument will be illustrated by a contemporary young adult novel, Slated (2012, by Teri Terry.

The Use of Memory.

Science.gov (United States)

Smith, R. D.

1983-01-01

The predominantly linguistic orientation to current educational thinking, with its emphasis on the abstract and indirect, does not solve the problem of achieving a sense of identity. Experiential memory is crucial in personal identity. The definition and use of experiential memory and its merit are explored. (SR)

Russian Dreams and Prussian Ghosts: Immanuel Kant Baltic Federal University and Debates over Historical Memory and Identity in Kaliningrad

Science.gov (United States)

Clarkson, Alexander

2017-01-01

This article examines how the Immanuel Kant Baltic Federal University and the Kaliningrad State Technical University have come to exert considerable influence over debates surrounding historical memory and identity in the Kaliningrad region. Under the direct control of the Russian Federation, the Baltic exclave of Kaliningrad is surrounded by…

Aqueous extracts from asparagus stems prevent memory impairments in scopolamine-treated mice.

Science.gov (United States)

Sui, Zifang; Qi, Ce; Huang, Yunxiang; Ma, Shufeng; Wang, Xinguo; Le, Guowei; Sun, Jin

2017-04-19

Aqueous extracts from Asparagus officinalis L. stems (AEAS) are rich in polysaccharides, gamma-amino butyric acid (GABA), and steroidal saponin. This study was designed to investigate the effects of AEAS on learning, memory, and acetylcholinesterase-related activity in a scopolamine-induced model of amnesia. Sixty ICR mice were randomly divided into 6 groups (n = 10) including the control group (CT), scopolamine group (SC), donepezil group (DON), low, medium, and high dose groups of AEAS (LS, MS, HS; 1.6 mL kg -1 , 8 mL kg -1 , 16 mL kg -1 ). The results showed that 8 mL kg -1 of AEAS used in this study significantly reversed scopolamine-induced cognitive impairments in mice in the novel object recognition test (P < 0.05) and the Y-maze test (P < 0.05), and also improved the latency to escape in the Morris water maze test (P < 0.05). Moreover, it significantly increased acetylcholine and inhibited acetylcholinesterase activity in the hippocampus, which was directly related to the reduction in learning and memory impairments. It also reversed scopolamine-induced reduction in the hippocampal brain-derived neurotrophic factor (BDNF) and the cAMP response element-binding protein (CREB) mRNA expression. AEAS protected against scopolamine-induced memory deficits. In conclusion, AEAS protected learning and memory function in mice by enhancing the activity of the cholinergic nervous system, and increasing BDNF and CREB expression. This suggests that AEAS has the potential to prevent cognitive impairments in age-related diseases, such as Alzheimer's disease.

Science Identity in Informal Education

Science.gov (United States)

Schon, Jennifer A.

The national drive to increase the number of students pursuing Science Technology, Engineering, and Math (STEM) careers has brought science identity into focus for educators, with the need to determine what encourages students to pursue and persist in STEM careers. Science identity, the degree to which students think someone like them could be a scientist is a potential indicator of students pursuing and persisting in STEM related fields. Science identity, as defined by Carlone and Johnson (2007) consists of three constructs: competence, performance, and recognition. Students need to feel like they are good at science, can perform it well, and that others recognize them for these achievements in order to develop a science identity. These constructs can be bolstered by student visitation to informal education centers. Informal education centers, such as outdoor science schools, museums, and various learning centers can have a positive impact on how students view themselves as scientists by exposing them to novel and unique learning opportunities unavailable in their school. Specifically, the University of Idaho's McCall Outdoor Science School (MOSS) focuses on providing K-12 students with the opportunity to learn about science with a place-based, hands-on, inquiry-based curriculum that hopes to foster science identity development. To understand the constructs that lead to science identity formation and the impact the MOSS program has on science identity development, several questions were explored examining how students define the constructs and if the MOSS program impacted how they rate themselves within each construct. A mixed-method research approach was used consisting of focus group interviews with students and pre, post, one-month posttests for visiting students to look at change in science identity over time. Results from confirmatory factor analysis indicate that the instrument created is a good fit for examining science identity and the associated

Inter-identity autobiographical amnesia in patients with dissociative identity disorder

OpenAIRE

Huntjens, Rafaele JC; Verschuere, Bruno; McNally, Richard J

2012-01-01

Background: A major symptom of Dissociative Identity Disorder (DID; formerly Multiple Personality Disorder) is dissociative amnesia, the inability to recall important personal information. Only two case studies have directly addressed autobiographical memory in DID. Both provided evidence suggestive of dissociative amnesia. The aim of the current study was to objectively assess transfer of autobiographical information between identities in a larger sample of DID patients. Methods: Using a c...

A comparison of three types of autobiographical memories in old-old age: first memories, pivotal memories and traumatic memories.

Science.gov (United States)

Cohen-Mansfield, Jiska; Shmotkin, Dov; Eyal, Nitza; Reichental, Yael; Hazan, Haim

2010-01-01

Autobiographical memory enables us to construct a personal narrative through which we identify ourselves. Especially important are memories of formative events. This study describes autobiographical memories of people who have reached old-old age (85 years and above), studying 3 types of memories of particular impact on identity and adaptation: first memories, pivotal memories and traumatic memories. In this paper, we examine the content, characteristic themes and environments, and structural characteristics of each of the 3 types of memory. The participants were 26 persons from a larger longitudinal study with an average age of 91 years; half were men and the other half women. The study integrated qualitative and quantitative tools. An open-ended questionnaire included questions about the participants' life story as well as questions about the 3 types of memories. The responses were rated by 3 independent judges on dimensions of central themes and structural characteristics. First memories had a more positive emotional tone, more references to characters from the participant's social circle, a stronger sense of group belonging, and a more narrative style than the other types of memories. Pivotal and traumatic memories were described as more personal than first memories. The 3 types of memories reflect different stages in life development, which together form a sense of identity. They present experiences from the past on select themes, which may assist in the complex task of coping with the difficulties and limitations that advanced old age presents. Future research should examine the functional role of those memories and whether they enable the old-old to support selfhood in the challenging period of last changes and losses. Copyright © 2010 S. Karger AG, Basel.

John locke on personal identity.

Science.gov (United States)

Nimbalkar, Namita

2011-01-01

John Locke speaks of personal identity and survival of consciousness after death. A criterion of personal identity through time is given. Such a criterion specifies, insofar as that is possible, the necessary and sufficient conditions for the survival of persons. John Locke holds that personal identity is a matter of psychological continuity. He considered personal identity (or the self) to be founded on consciousness (viz. memory), and not on the substance of either the soul or the body.

John Locke on Personal Identity**

OpenAIRE

Nimbalkar, Namita

2011-01-01

John Locke speaks of personal identity and survival of consciousness after death. A criterion of personal identity through time is given. Such a criterion specifies, insofar as that is possible, the necessary and sufficient conditions for the survival of persons. John Locke holds that personal identity is a matter of psychological continuity. He considered personal identity (or the self) to be founded on consciousness (viz. memory), and not on the substance of either the soul or the body.

Short-term memory for emotional faces in dysphoria.

Science.gov (United States)

Noreen, Saima; Ridout, Nathan

2010-07-01

The study aimed to determine if the memory bias for negative faces previously demonstrated in depression and dysphoria generalises from long- to short-term memory. A total of 29 dysphoric (DP) and 22 non-dysphoric (ND) participants were presented with a series of faces and asked to identify the emotion portrayed (happiness, sadness, anger, or neutral affect). Following a delay, four faces were presented (the original plus three distractors) and participants were asked to identify the target face. Half of the trials assessed memory for facial emotion, and the remaining trials examined memory for facial identity. At encoding, no group differences were apparent. At memory testing, relative to ND participants, DP participants exhibited impaired memory for all types of facial emotion and for facial identity when the faces featured happiness, anger, or neutral affect, but not sadness. DP participants exhibited impaired identity memory for happy faces relative to angry, sad, and neutral, whereas ND participants exhibited enhanced facial identity memory when faces were angry. In general, memory for faces was not related to performance at encoding. However, in DP participants only, memory for sad faces was related to sadness recognition at encoding. The results suggest that the negative memory bias for faces in dysphoria does not generalise from long- to short-term memory.

Genome-wide RNA profiling of long-lasting stem cell-like memory CD8 T cells induced by Yellow Fever vaccination in humans

Directory of Open Access Journals (Sweden)

Silvia A. Fuertes Marraco

2015-09-01

Full Text Available The live-attenuated Yellow Fever (YF vaccine YF-17D induces a broad and polyfunctional CD8 T cell response in humans. Recently, we identified a population of stem cell-like memory CD8 T cells induced by YF-17D that persists at stable frequency for at least 25 years after vaccination. The YF-17D is thus a model system of human CD8 T cell biology that furthermore allows to track and study long-lasting and antigen-specific human memory CD8 T cells. Here, we describe in detail the sample characteristics and preparation of a microarray dataset acquired for genome-wide gene expression profiling of long-lasting YF-specific stem cell-like memory CD8 T cells, compared to the reference CD8 T cell differentiation subsets from total CD8 T cells. We also describe the quality controls, annotations and exploratory analyses of the dataset. The microarray data is available from the Gene Expression Omnibus (GEO public repository with accession number GSE65804.

Inter-identity autobiographical amnesia in patients with dissociative identity disorder

NARCIS (Netherlands)

Huntjens, R.J.C.; Verschuere, B.; McNally, R.J.

2012-01-01

Background A major symptom of Dissociative Identity Disorder (DID; formerly Multiple Personality Disorder) is dissociative amnesia, the inability to recall important personal information. Only two case studies have directly addressed autobiographical memory in DID. Both provided evidence suggestive

Inter-Identity Autobiographical Amnesia in Patients with Dissociative Identity Disorder

NARCIS (Netherlands)

Huntjens, R.J.C.; Verschuere, B.; McNally, R.J.

2012-01-01

Background: A major symptom of Dissociative Identity Disorder (DID; formerly Multiple Personality Disorder) is dissociative amnesia, the inability to recall important personal information. Only two case studies have directly addressed autobiographical memory in DID. Both provided evidence suggestive

Medial prefrontal-hippocampal connectivity during emotional memory encoding predicts individual differences in the loss of associative memory specificity.

Science.gov (United States)

Berkers, Ruud M W J; Klumpers, Floris; Fernández, Guillén

2016-10-01

Emotionally charged items are often remembered better, whereas a paradoxical loss of specificity is found for associative emotional information (specific memory). The balance between specific and generalized emotional memories appears to show large individual differences, potentially related to differences in (the risk for) affective disorders that are characterized by 'overgeneralized' emotional memories. Here, we investigate the neural underpinnings of individual differences in emotional associative memory. A large group of healthy male participants were scanned while encoding associations of face-photographs and written occupational identities that were of either neutral ('driver') or negative ('murderer') valence. Subsequently, memory was tested by prompting participants to retrieve the occupational identities corresponding to each face. Whereas in both valence categories a similar amount of faces was labeled correctly with 'neutral' and 'negative' identities, (gist memory), specific associations were found to be less accurately remembered when the occupational identity was negative compared to neutral (specific memory). This pattern of results suggests reduced memory specificity for associations containing a negatively valenced component. The encoding of these negative associations was paired with a selective increase in medial prefrontal cortex activity and medial prefrontal-hippocampal connectivity. Individual differences in valence-specific neural connectivity were predictive of valence-specific reduction of memory specificity. The relationship between loss of emotional memory specificity and medial prefrontal-hippocampal connectivity is in line with the hypothesized role of a medial prefrontal-hippocampal circuit in regulating memory specificity, and warrants further investigations in individuals displaying 'overgeneralized' emotional memories. Copyright © 2016 Elsevier Inc. All rights reserved.

Designing Philadelphia Land Science as a Game to Promote Identity Exploration

Science.gov (United States)

Barany, Amanda; Shah, Mamta; Cellitti, Jessica; Duka, Migela; Swiecki, Zachari; Evenstone, Amanda; Kinley, Hannah; Quigley, Peter; Shaffer, David Williamson; Foster, Aroutis

2017-01-01

Few digital tools are designed to support identity exploration around careers in science, technology, engineering, and mathematics (STEM) that may help close existing representation gaps in STEM fields. The aim of this project is to inform the design of games that facilitate learning as identity change as defined by the Projective Reflection…

Modulation of Autoimmune T-Cell Memory by Stem Cell Educator Therapy: Phase 1/2 Clinical Trial.

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Delgado, Elias; Perez-Basterrechea, Marcos; Suarez-Alvarez, Beatriz; Zhou, Huimin; Revuelta, Eva Martinez; Garcia-Gala, Jose Maria; Perez, Silvia; Alvarez-Viejo, Maria; Menendez, Edelmiro; Lopez-Larrea, Carlos; Tang, Ruifeng; Zhu, Zhenlong; Hu, Wei; Moss, Thomas; Guindi, Edward; Otero, Jesus; Zhao, Yong

2015-12-01

Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease that causes a deficit of pancreatic islet β cells. The complexities of overcoming autoimmunity in T1D have contributed to the challenges the research community faces when devising successful treatments with conventional immune therapies. Overcoming autoimmune T cell memory represents one of the key hurdles. In this open-label, phase 1/phase 2 study, Caucasian T1D patients (N = 15) received two treatments with the Stem Cell Educator (SCE) therapy, an approach that uses human multipotent cord blood-derived multipotent stem cells (CB-SCs). SCE therapy involves a closed-loop system that briefly treats the patient's lymphocytes with CB-SCs in vitro and returns the "educated" lymphocytes (but not the CB-SCs) into the patient's blood circulation. This study is registered with ClinicalTrials.gov, NCT01350219. Clinical data demonstrated that SCE therapy was well tolerated in all subjects. The percentage of naïve CD4(+) T cells was significantly increased at 26 weeks and maintained through the final follow-up at 56 weeks. The percentage of CD4(+) central memory T cells (TCM) was markedly and constantly increased at 18 weeks. Both CD4(+) effector memory T cells (TEM) and CD8(+) TEM cells were considerably decreased at 18 weeks and 26 weeks respectively. Additional clinical data demonstrated the modulation of C-C chemokine receptor 7 (CCR7) expressions on naïve T, TCM, and TEM cells. Following two treatments with SCE therapy, islet β-cell function was improved and maintained in individuals with residual β-cell function, but not in those without residual β-cell function. Current clinical data demonstrated the safety and efficacy of SCE therapy in immune modulation. SCE therapy provides lasting reversal of autoimmune memory that could improve islet β-cell function in Caucasian subjects. Obra Social "La Caixa", Instituto de Salud Carlos III, Red de Investigación Renal, European Union FEDER Funds, Principado de

Effects of Oxytocin on Facial Expression and Identity Working Memory Are Found in Females but Not Males.

Science.gov (United States)

Yue, Tong; Yue, Caizhen; Liu, Guangyuan; Huang, Xiting

2018-01-01

Although oxytocin (OXT) has been shown to increase the ability of face perception and processing, no study has explored whether it could improve the performance of working memory for emotional expression information in males and females. Thus, we performed a double-blind, mixed-design, placebo-controlled study to investigate the effects of OXT on temporary maintenance/manipulation of facial information through a facial expression (EMO) vs. identity (ID) working memory task, both for males ( N = 45) and females ( N = 46). Our results showed that in female participants, OXT increased the accuracy of the recognition of faces displaying angry and happy emotions, in the EMO tasks, and also reduced the response time to negative emotional faces, in the ID task. However, the above effects were not present in male subjects. These results indicate that OXT may increase the efficiency of working memory in face processing and this trend is reflected in females rather than in males. This study provides novel evidence for the sexually dimorphic effects of OXT on social cognition.

Effects of Oxytocin on Facial Expression and Identity Working Memory Are Found in Females but Not Males

Directory of Open Access Journals (Sweden)

Tong Yue

2018-04-01

Full Text Available Although oxytocin (OXT has been shown to increase the ability of face perception and processing, no study has explored whether it could improve the performance of working memory for emotional expression information in males and females. Thus, we performed a double-blind, mixed-design, placebo-controlled study to investigate the effects of OXT on temporary maintenance/manipulation of facial information through a facial expression (EMO vs. identity (ID working memory task, both for males (N = 45 and females (N = 46. Our results showed that in female participants, OXT increased the accuracy of the recognition of faces displaying angry and happy emotions, in the EMO tasks, and also reduced the response time to negative emotional faces, in the ID task. However, the above effects were not present in male subjects. These results indicate that OXT may increase the efficiency of working memory in face processing and this trend is reflected in females rather than in males. This study provides novel evidence for the sexually dimorphic effects of OXT on social cognition.

Science identity possibilities: a look into Blackness, masculinities, and economic power relations

Science.gov (United States)

Rosa, Katemari

2018-02-01

This forum paper dialogues with Sheron Mark's A bit of both science and economics: a non-traditional STEM identity narrative. In her paper, she discusses the development of a Science, Technology, Engineering, and Mathematics (STEM) identity by a young African American male during an informal STEM for Social Justice Program. Here, the discussion focuses on Black masculinities, identity formation, and the role of science educators in making STEM fields a welcoming place for young Black men. Drawing from Mark's data and discussion, this paper is a dialogue between science identity possibilities in the United States and in Brazil when we look at the intersections of race, gender, and socioeconomic status. Using the shared colonial past of both countries a connection is established to address race relations within science education. The main argument in this paper is that racism can no longer be denied and dismissed by the science education community worldwide and that intersectional approaches are needed to face this issue.

Resolving an identity crisis: Implicit drinking identity and implicit alcohol identity are related but not the same.

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Ramirez, Jason J; Olin, Cecilia C; Lindgren, Kristen P

2017-09-01

Two variations of the Implicit Association Test (IAT), the Drinking Identity IAT and the Alcohol Identity IAT, assess implicit associations held in memory between one's identity and alcohol-related constructs. Both have been shown to predict numerous drinking outcomes, but these IATs have never been directly compared to one another. The purpose of this study was to compare these IATs and evaluate their incremental predictive validity. US undergraduate students (N=64, 50% female, mean age=21.98years) completed the Drinking Identity IAT, the Alcohol Identity IAT, an explicit measure of drinking identity, as well as measures of typical alcohol consumption and hazardous drinking. When evaluated in separate regression models that controlled for explicit drinking identity, results indicated that the Drinking Identity IAT and the Alcohol Identity IAT were significant, positive predictors of typical alcohol consumption, and that the Drinking Identity IAT, but not the Alcohol Identity IAT, was a significant predictor of hazardous drinking. When evaluated in the same regression models, the Drinking Identity IAT, but not the Alcohol Identity IAT, was significantly associated with typical and hazardous drinking. These results suggest that the Drinking Identity IAT and Alcohol Identity IAT are related but not redundant. Moreover, given that the Drinking Identity IAT, but not the Alcohol Identity IAT, incrementally predicted variance in drinking outcomes, identification with drinking behavior and social groups, as opposed to identification with alcohol itself, may be an especially strong predictor of drinking outcomes. Copyright © 2017 Elsevier Ltd. All rights reserved.

New rather than old? For working memory tasks with abstract patterns the P3 and the single-trial delta response are larger for modified than identical probe stimuli.

Science.gov (United States)

Mathes, B; Schmiedt, J; Schmiedt-Fehr, C; Pantelis, C; Basar-Eroglu, C

2012-07-01

Memory-guided decision making is dynamic and context-dependent, even though many studies describe an enhancement of the P3 for recognized items in memory tasks ("old-new effect"). This study utilized a delay-dependent working memory task during which decision making could be optimized by focusing attention on detected changes instead of recognized similarities. Mean P3 amplitude and delta activity were analyzed from participants who classified probe stimuli as identical or modified. The P3 amplitudes were larger for modified than for identical probes, even when the probe occurred 4,000 ms after the primary stimulus. Enhanced single-trial amplitude, trial-by-trial consistency, and frontoparietal phase coherence of delta activity contributed to the larger P3 for the modified probe. Thus, context-dependent attentional resource allocation supporting memory-guided decisions might explain the enhancement of the P3 for specific probe types. Copyright © 2012 Society for Psychophysiological Research.

'Gay times': identity, locality, memory, and the Brixton squats in 1970's London.

Science.gov (United States)

Cook, Matt

2013-01-01

Through a thick description of a gay squatting community in south London in the 1970s, this piece explores the ways in which local histories complicate broader accounts of gay life, politics, and culture. Such a focus alerts us to the impact of personal encounters, of local politics, and material circumstances, of coincident local communities, of jobs (or the lack of them), and of major local events (like the Brixton riots of 1981). The local focus and the oral history sources also illuminate the complex ways in which unspoken and often unconscious imperatives associated with ethnicity, class, and the familial, social, and cultural contexts of our upbringings are played out under new and changing circumstances. Taking this approach fractures homogenizing assumptions about gay identity and community--even of a self-identified gay community like this squatting collective. It can also decentre sexuality as a primary category of identity and analysis as other factors come into sharper focus and shed light on the ebb and flow of identification and on the ways in which broader histories are woven into everyday lives. The piece thus considers different scales of analysis, the limits of identification, the inclusions and exclusions enacted when communities come together and identities coalesce, the continuities and discontinuities between broader and counter cultures (especially in relation to ideas and lived experiences of home), and the way memories of the squats and of the 1970s are modulated by subsequent national and gay politics, by AIDS, and by a profound sense of loss.

High School Students' Perception of University Students as STEM Representatives

DEFF Research Database (Denmark)

Poulsen, Eva Lykkegaard

’ potential identities. It shows that the students preferred STEM representatives resembled themselves in some aspects (primarily social and health aspects) and fit their perceptions of a typical person working in STEM in other aspects (knowledge seeking, hard-working etc.). At least two different...... studies, it is important to introduce high school students to good STEM representatives to make possible the development of potential STEM identities. A potential identity within a specific subject area relies on at least a situation bound relation-ship to the subject area or the person representing it....... Some representatives transmit infor-mation and are thereby definers, whereas other representatives illustrates as personal examples and are thereby models. This study focuses on high school students’ views on STEM representatives and the impact these representatives have on the high school students...

Long-term human immune system reconstitution in non-obese diabetic (NOD)-Rag (-)-γ chain (-) (NRG) mice is similar but not identical to the original stem cell donor.

Science.gov (United States)

Harris, D T; Badowski, M; Balamurugan, A; Yang, O O

2013-12-01

The murine immune system is not necessarily identical to it human counterpart, which has led to the construction of humanized mice. The current study analysed whether or not a human immune system contained within the non-obese diabetic (NOD)-Rag1(null) -γ chain(null) (NRG) mouse model was an accurate representation of the original stem cell donor and if multiple mice constructed from the same donor were similar to one another. To that end, lightly irradiated NRG mice were injected intrahepatically on day 1 of life with purified cord blood-derived CD34(+) stem and progenitor cells. Multiple mice were constructed from each cord blood donor. Mice were analysed quarterly for changes in the immune system, and followed for periods up to 12 months post-transplant. Mice from the same donor were compared directly with each other as well as with the original donor. Analyses were performed for immune reconstitution, including flow cytometry, T cell receptor (TCR) and B cell receptor (BCR) spectratyping. It was observed that NRG mice could be 'humanized' long-term using cord blood stem cells, and that animals constructed from the same cord blood donor were nearly identical to one another, but quite different from the original stem cell donor immune system. © 2013 British Society for Immunology.

Diluted Blood: Identity and the Other in Three Novels by Doeschka Meijsing

Directory of Open Access Journals (Sweden)

Lammer Christina

2016-11-01

Full Text Available Two hypotheses on identity lay at the core of this paper. (1 Doeschka Meijsing presents identity as unstable and as a construct of one’s own in three novels. (2 Meijsing uses memory discourses and cultural phenomena to display how characters struggle when (re-constructing their identities. Pip (Over de liefde, 2008, has to deal with the secret affair of her female lover who has got pregnant. She refuses to be the ‘left one’ everyone feels pity for. As a result, she has to create a new identity that doesn’t fit the expectations of others. In 100% Chemie (2002, an unnamed daughter of a German migrant and Dutch father grew up in the Netherlands. As she doesn’t identify with any nationality she seeks to stabilize her fragmented identity. Investigating the history of her German family she tries to create her own identity. Robert Martin, main character of De tweede man (2000, struggles with the legacy of his brother Alexander who has passed away. Robert has not only inherited his brother’s fortune but also his friends. They want Robert to replace Alexander. Robert has to create a new identity which fits their lifestyle. Meijsing’s characters feel as if they have ‘lost’ their identities, as far as they ‘owned’ ones. As a result, their stories stress views on identity: do they have fixed identities, which can be destroyed? Is identity a construction and if so, how can it be created? I discuss how cultural memory, especially counter-memory which questions memory discourses, impacts the construction of identity. Furthermore, I show how intersections of identity categories trouble Meijsing’s characters.

Bone Marrow Mesenchymal Stem Cells Enhance the Differentiation of Human Switched Memory B Lymphocytes into Plasma Cells in Serum-Free Medium

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Guillaume Bonnaure

2016-01-01

Full Text Available The differentiation of human B lymphocytes into plasma cells is one of the most stirring questions with regard to adaptive immunity. However, the terminal differentiation and survival of plasma cells are still topics with much to be discovered, especially when targeting switched memory B lymphocytes. Plasma cells can migrate to the bone marrow in response to a CXCL12 gradient and survive for several years while secreting antibodies. In this study, we aimed to get closer to niches favoring plasma cell survival. We tested low oxygen concentrations and coculture with mesenchymal stem cells (MSC from human bone marrow. Besides, all cultures were performed using an animal protein-free medium. Overall, our model enables the generation of high proportions of CD38+CD138+CD31+ plasma cells (≥50% when CD40-activated switched memory B lymphocytes were cultured in direct contact with mesenchymal stem cells. In these cultures, the secretion of CXCL12 and TGF-β, usually found in the bone marrow, was linked to the presence of MSC. The level of oxygen appeared less impactful than the contact with MSC. This study shows for the first time that expanded switched memory B lymphocytes can be differentiated into plasma cells using exclusively a serum-free medium.

Differential contributions of the anterior temporal and medial temporal lobe to the retrieval of memory for person identity information.

Science.gov (United States)

Tsukiura, Takashi; Suzuki, Chisato; Shigemune, Yayoi; Mochizuki-Kawai, Hiroko

2008-12-01

Although previous studies have suggested the importance of the bilateral anterior temporal (ATL) and medial temporal lobes (MTL) in the retrieval of person identity information, there is little evidence concerning how these regions differentially contribute to the process. Here we investigated this question using functional magnetic resonance imaging (fMRI). Before scanning, subjects learned associations among faces (F), names (N), and job titles (as a form of person-related semantics, S). During retrieval with fMRI, subjects were presented with previously learned and new S stimuli, and judged whether the stimuli were old or new. Successful retrieval (H) trials were divided into three conditions: retrieval of S and associated F and N (HSFN); retrieval of S and associated F (HSF); and retrieval of S only (HS). The left ATL was significantly activated in HSFN, compared to HSF or HS, whereas the right ATL and MTL were significantly activated in HSFN and HSF relative to HS. In addition, activity in bilateral ATL was significantly correlated with reaction time for HSFN, whereas we found no significant correlation between activity in the right MTL and reaction time in any condition. The present findings suggest that the left ATL may mediate associations between names and person-related semantic information, whereas the right ATL mediates the association between faces and person-related semantic information in memory for person identity information. In addition, activation of the right MTL region implies that this area may contribute to a more general relational processing of associative components, including memory for person identity information. Copyright 2007 Wiley-Liss, Inc.

Transfer of newly acquired stimulus valence between identities in dissociative identity disorder (DID).

Science.gov (United States)

Huntjens, Rafaële J C; Peters, Madelon L; Postma, Albert; Woertman, Liesbeth; Effting, Marieke; van der Hart, Onno

2005-02-01

Patients with Dissociative Identity Disorder (DID) frequently report episodes of interidentity amnesia, that is amnesia for events experienced by other identities. The goal of the present experiment was to test the implicit transfer of trauma-related information between identities in DID. We hypothesized that whereas declarative information may transfer from one identity to another, the emotional connotation of the memory may be dissociated, especially in the case of negative, trauma-related emotional valence. An evaluative conditioning procedure was combined with an affective priming procedure, both performed by different identities. In the evaluative conditioning procedure, previously neutral stimuli come to refer to a negative or positive connotation. The affective priming procedure was used to test the transfer of this acquired valence to an identity reporting interidentity amnesia. Results indicated activation of stimulus valence in the affective priming task, that is transfer of emotional material between identities.

Unstable identity compatibility: how gender rejection sensitivity undermines the success of women in science, technology, engineering, and mathematics fields.

Science.gov (United States)

Ahlqvist, Sheana; London, Bonita; Rosenthal, Lisa

2013-09-01

Although the perceived compatibility between one's gender and science, technology, engineering, and mathematics (STEM) identities (gender-STEM compatibility) has been linked to women's success in STEM fields, no work to date has examined how the stability of identity over time contributes to subjective and objective STEM success. In the present study, 146 undergraduate female STEM majors rated their gender-STEM compatibility weekly during their freshman spring semester. STEM women higher in gender rejection sensitivity, or gender RS, a social-cognitive measure assessing the tendency to perceive social-identity threat, experienced larger fluctuations in gender-STEM compatibility across their second semester of college. Fluctuations in compatibility predicted impaired outcomes the following school year, including lower STEM engagement and lower academic performance in STEM (but not non-STEM) classes, and significantly mediated the relationship between gender RS and STEM engagement and achievement in the 2nd year of college. The week-to-week changes in gender-STEM compatibility occurred in response to negative academic (but not social) experiences.

«I shall Intervene, With Nomad Memory and Intermittent Voice»: Resurrecting Collective Memory in Assia Djebar’s Fantasia, an Algerian Cavalcade

Directory of Open Access Journals (Sweden)

Ben Salem, Lobna

2011-01-01

Full Text Available In Assia Djebar’s war narratives, it is women’s voices and experiences that are at the centre of narration, in contrast to traditional male-centred narratives of war and conflict. In Fantasia,an Algerian Cavalcade, there are multiple female protagonists, survivors of independence war, who, through storytelling, present shifting perspectives and a multiplicity of voices that contest monological historical versions. By reassembling the fragments of individual identities, lost and forgotten by history, the writer forges collective identity, focussing on the communal rather thanprivate aspect of memory.The paper highlights the gender-specific nature of war memories; it examines the role of the narrative as a means of countering deficiencies of memory and combating historic amnesia.Centred on the idea that memory constructs identity, the paper investigates the extent to which a gendered memory of war can contribute in shaping collective identity, bearing in mind theinterdependence but also the dissonance of orality and texting.

Apparent Amnesia : interidentity memory functioning in dissociative identity disdorder

NARCIS (Netherlands)

Huntjens, R.J.C.

2003-01-01

Dissociative identity disorder (DID) is characterized by the presence of two or more distinct identities or personality states that recurrently take control of the individual s behavior. Between 95 and 100 % of DID patients report experiences of blank spells for periods of time when other identities

Memory-Modulation: Self-Improvement or Self-Depletion?

Science.gov (United States)

Lavazza, Andrea

2018-01-01

Autobiographical memory is fundamental to the process of self-construction. Therefore, the possibility of modifying autobiographical memories, in particular with memory-modulation and memory-erasing, is a very important topic both from the theoretical and from the practical point of view. The aim of this paper is to illustrate the state of the art of some of the most promising areas of memory-modulation and memory-erasing, considering how they can affect the self and the overall balance of the "self and autobiographical memory" system. Indeed, different conceptualizations of the self and of personal identity in relation to autobiographical memory are what makes memory-modulation and memory-erasing more or less desirable. Because of the current limitations (both practical and ethical) to interventions on memory, I can only sketch some hypotheses. However, it can be argued that the choice to mitigate painful memories (or edit memories for other reasons) is somehow problematic, from an ethical point of view, according to some of the theories of the self and personal identity in relation to autobiographical memory, in particular for the so-called narrative theories of personal identity, chosen here as the main case of study. Other conceptualizations of the "self and autobiographical memory" system, namely the constructivist theories, do not have this sort of critical concerns. However, many theories rely on normative (and not empirical) conceptions of the self: for them, the actions aimed at mitigating or removing specific (negative) memories can be seen either as an improvement or as a depletion or impairment of the self.

Contribution of past and future self-defining event networks to personal identity.

Science.gov (United States)

Demblon, Julie; D'Argembeau, Arnaud

2017-05-01

Personal identity is nourished by memories of significant past experiences and by the imagination of meaningful events that one anticipates to happen in the future. The organisation of such self-defining memories and prospective thoughts in the cognitive system has received little empirical attention, however. In the present study, our aims were to investigate to what extent self-defining memories and future projections are organised in networks of related events, and to determine the nature of the connections linking these events. Our results reveal the existence of self-defining event networks, composed of both memories and future events of similar centrality for identity and characterised by similar identity motives. These self-defining networks expressed a strong internal coherence and frequently organised events in meaningful themes and sequences (i.e., event clusters). Finally, we found that the satisfaction of identity motives in represented events and the presence of clustering across events both contributed to increase in the perceived centrality of events for the sense of identity. Overall, these findings suggest that personal identity is not only nourished by representations of significant past and future events, but also depends on the formation of coherent networks of related events that provide an overarching meaning to specific life experiences.

Defining the identity of human adipose-derived mesenchymal stem cells.

Science.gov (United States)

Montelatici, Elisa; Baluce, Barbara; Ragni, Enrico; Lavazza, Cristiana; Parazzi, Valentina; Mazzola, Riccardo; Cantarella, Giovanna; Brambilla, Massimiliano; Giordano, Rosaria; Lazzari, Lorenza

2015-02-01

Adipose-derived mesenchymal stem cells (ADMSCs) are an ideal population for regenerative medical application. Both the isolation procedure and the culturing conditions are crucial steps, since low yield can limit further cell therapies, especially when minimal adipose tissue harvests are available for cell expansion. To date, a standardized procedure encompassing both isolation sites and expansion methods is missing, thus making the choice of the most appropriate conditions for the preparation of ADMSCs controversial, especially in view of the different applications needed. In this study, we compared the effects of three different commercial media (DMEM, aMEM, and EGM2), routinely used for ADMSCs expansion, and two supplements, FBS and human platelet lysate, recently proven to be an effective alternative to prevent xenogeneic antibody transfer and immune alloresponse in the host. Notably, all the conditions resulted in being safe for ADMSCs isolation and expansion with platelet lysate supplementation giving the highest isolation and proliferation rates, together with a commitment for osteogenic lineage. Then, we proved that the high ADMSC hematopoietic supportive potential is performed through a constant and abundant secretion of both GCSF and SCF. In conclusion, this study further expands the knowledge on ADMSCs, defining their identity definition and offers potential options for in vitro protocols for clinical production, especially related to HSC expansion without use of exogenous cytokines or genetic modifications.

A model of memory impairment in schizophrenia: cognitive and clinical factors associated with memory efficiency and memory errors.

Science.gov (United States)

Brébion, Gildas; Bressan, Rodrigo A; Ohlsen, Ruth I; David, Anthony S

2013-12-01

Memory impairments in patients with schizophrenia have been associated with various cognitive and clinical factors. Hallucinations have been more specifically associated with errors stemming from source monitoring failure. We conducted a broad investigation of verbal memory and visual memory as well as source memory functioning in a sample of patients with schizophrenia. Various memory measures were tallied, and we studied their associations with processing speed, working memory span, and positive, negative, and depressive symptoms. Superficial and deep memory processes were differentially associated with processing speed, working memory span, avolition, depression, and attention disorders. Auditory/verbal and visual hallucinations were differentially associated with specific types of source memory error. We integrated all the results into a revised version of a previously published model of memory functioning in schizophrenia. The model describes the factors that affect memory efficiency, as well as the cognitive underpinnings of hallucinations within the source monitoring framework. © 2013.

Memory-Modulation: Self-Improvement or Self-Depletion?

Directory of Open Access Journals (Sweden)

Andrea Lavazza

2018-04-01

Full Text Available Autobiographical memory is fundamental to the process of self-construction. Therefore, the possibility of modifying autobiographical memories, in particular with memory-modulation and memory-erasing, is a very important topic both from the theoretical and from the practical point of view. The aim of this paper is to illustrate the state of the art of some of the most promising areas of memory-modulation and memory-erasing, considering how they can affect the self and the overall balance of the “self and autobiographical memory” system. Indeed, different conceptualizations of the self and of personal identity in relation to autobiographical memory are what makes memory-modulation and memory-erasing more or less desirable. Because of the current limitations (both practical and ethical to interventions on memory, I can only sketch some hypotheses. However, it can be argued that the choice to mitigate painful memories (or edit memories for other reasons is somehow problematic, from an ethical point of view, according to some of the theories of the self and personal identity in relation to autobiographical memory, in particular for the so-called narrative theories of personal identity, chosen here as the main case of study. Other conceptualizations of the “self and autobiographical memory” system, namely the constructivist theories, do not have this sort of critical concerns. However, many theories rely on normative (and not empirical conceptions of the self: for them, the actions aimed at mitigating or removing specific (negative memories can be seen either as an improvement or as a depletion or impairment of the self.

Memorar la cultura: Modos de mantener y formar las identidades mayas modernas Memorialize Culture: Ways to Mantain and Form Modern Mayan Identities

Directory of Open Access Journals (Sweden)

Felix A. Kupprat

2011-01-01

Full Text Available Memoria ha sido una palabra clave en el proceso de paz en Guatemala durante los últimos quince años. De acuerdo con teorías de la memoria colectiva, ésta forma la identidad de grupos y es sustancial para la construcción y el mantenimiento de la cultura. Al contrastar el movimiento maya con estrategias locales para la conmemoración de las violaciones de los derechos humanos durante el conflicto armado, este artículo conecta el concepto de etnicidad a nivel interregional con la identidad étnica local. Por lo tanto, se propone una división entre los marcadores étnicos sincrónicos y los asincrónicos de la etnicidad maya: el primero se asocia con elementos culturales locales y el segundo con procesos de revitalización. Finalmente, se plantea que los rasgos estructurales, como la memoria cultural, deben ser considerados marcadores étnicos en ambos niveles: el local y el interregional.Memory has been a keyword for the peace process in Guatemala in the last fifteen years. According to theories on collective memory it shapes group identities and is crucial for the construction and maintenance of culture. Contrasting maya cultural activism and local commemorative strategies dealing with human rights violations during the civil war, this paper aims to connect ethnicity on an inter-regional and ethnic identity on a local level. Therefore a division will be made between synchronous and asynchronous ethnic markers of pan-maya identity, associating the former with cultural elements on a local level and the latter with revitalization processes. Finally it is proposed that structural features such as cultural memory should be considered crucial ethnic markers on both levels: the local and the inter-regional.

A theoretical framework for understanding recovered memory experiences.

Science.gov (United States)

Brewin, Chris R

2012-01-01

If recovered memory experiences appear counter-intuitive, this is in part due to misconceptions about trauma and memory, and to a failure to adopt a comprehensive model of memory that distinguishes personal semantic memory, autobiographical event memory, and memory appraisal. Memory performance is generally superior when events, including traumas, are central to identity. Prolonged trauma in childhood, however, can produce severe identity disturbances that may interfere with the encoding and later retrieval of personal semantic and autobiographical event information. High levels of emotion either at encoding or recall can also interfere with the creation of coherent narrative memories. For example, high levels of shock and fear when memories are recovered unexpectedly may lead to the experience of vivid flashbacks. Memory appraisals may also influence the sense that an event has been forgotten for a long time. Recovered memories, although unusual, do not contradict what we know about how memory works.

Cancer immunotherapy and immunological memory.

Science.gov (United States)

Murata, Kenji; Tsukahara, Tomohide; Torigoe, Toshihiko

2016-01-01

Human immunological memory is the key distinguishing hallmark of the adaptive immune system and plays an important role in the prevention of morbidity and the severity of infection. The differentiation system of T cell memory has been clarified using mouse models. However, the human T cell memory system has great diversity induced by natural antigens derived from many pathogens and tumor cells throughout life, and profoundly differs from the mouse memory system constructed using artificial antigens and transgenic T cells. We believe that only human studies can elucidate the human immune system. The importance of immunological memory in cancer immunotherapy has been pointed out, and the trafficking properties and long-lasting anti-tumor capacity of memory T cells play a crucial role in the control of malignant tumors. Adoptive cell transfer of less differentiated T cells has consistently demonstrated superior anti-tumor capacity relative to more differentiated T cells. Therefore, a human T cell population with the characteristics of stem cell memory is thought to be attractive for peptide vaccination and adoptive cell transfer. A novel human memory T cell population that we have identified is closer to the naive state than previous memory T cells in the T cell differentiation lineage, and has the characteristics of stem-like chemoresistance. Here we introduce this novel population and describe the fundamentals of immunological memory in cancer immunotherapy.

The constitution of marginalized identity in Signs of identity by Juan Goytisolo

Directory of Open Access Journals (Sweden)

Jelica Veljović

2014-12-01

Full Text Available The main objective of the article is to investigate the modes of constitution of a marginalized and exiled identity in the novel Signs of identity by Juan Goytisolo. It is categorised as a “testimony and postwar novel”, and the subjects’ constant search of themselves, of their Self and all the elements that constitute their identity is central to the work. The novel is set in the postwar socio-historical period and the protagonist – Alvaro Mendiola – searches for his identity in his childhood memories and family pictures, but also amongst all the Others whose life stories intertwine with his journey of identification. Tracing his line of identity formation, we found three different routes: the first through the genealogical records, the second through the concept of Otherness and the last one through love. We find Identity as a kaleidoscope containing all the Others who served as moulds for his Identity, yet leaving it undefined and incomplete. Therefore, the identity of an exiled and marginalized individual is always in flux, continually reinitiating the constitution of the Self that had been eradicated from its first and formative imagery: the family and the fatherland.

The rise and fall of gay: a cultural-historical approach to gay identity development.

Science.gov (United States)

Weststrate, Nic M; McLean, Kate C

2010-02-01

Research on identity development has paid relatively little attention to the development of marginalised identities such as those of gays and lesbians, whose isolation from the canonical narrative of sexuality may limit the available resources required for establishing a coherent identity. We examined these contested identities in relation to cultural-historical factors that may have played a role in shaping these identities over the past 50 years, and looked at how such factors have impacted the voicing and silencing of gay experiences. Participants (N=251) reported (1) a memory of a cultural event relevant to their sexuality, and (2) a self-defining memory about their sexuality. Those in older cohorts reported cultural memories centred on politics and other external events (e.g., Stonewall riots), and younger cohorts reported more personal memories (e.g., coming out), suggesting that homosexual identities have become less culturally defined, and instead more personally defined. Further, participants of older cohorts reported self-defining events that were predominantly from one private domain (e.g., sex). In contrast, younger participants reported a variety of self-defining events. These results suggest that cultural-historical factors play an important role in defining the developmental pathway of individuals, perhaps especially those who have marginalised identities.

Implicit and explicit memory in survivors of chronic interpersonal violence.

Science.gov (United States)

Minshew, Reese; D'Andrea, Wendy

2015-01-01

We investigated the relationship of implicit and explicit memory to a range of symptoms in a sample of 27 women with exposure to chronic interpersonal violence (IPV). Participants viewed the first 3 letters ("stems") of trauma-related, general threat, and neutral words; valenced words were matched with neutral words with the same stem. Free recall and a word-stem completion task were used to test explicit and implicit memory, respectively. Participants exhibited increased implicit memory for trauma-related words as compared with both general threat words and neutral "match" words. They also showed increased explicit memory for both general threat and trauma-related words. Finally, although neither implicit nor explicit memory was correlated with PTSD symptoms, implicit memory for trauma-related words was significantly correlated with symptoms associated with ongoing IPV. Interpersonal sensitivity, hostility, and alexithymia were significantly correlated with implicit, but not explicit, memory for trauma words. Somatization, dissociation, and alexithymia were negatively correlated with explicit, but not implicit, memory for general-threat words. These findings suggest that memory processes in survivors of IPV are closely related to the symptom profile associated with complex trauma. Exploring memory processes in survivors of IPV may lend unique insight into the development and maintenance of the symptom profile associated with IPV. (c) 2015 APA, all rights reserved).

Ultrasonic identity data storage and archival system

International Nuclear Information System (INIS)

Mc Kenzie, J.M.; Self, B.G.; Walker, J.E.

1987-01-01

Ultrasonic seals are being used to determine if an underwater stored spent fuel container has been compromised and can be used to determine if a nuclear material container has been compromised. The Seal Pattern Reader (SPAR) is a microprocessor controlled instrument which interrogates an ultrasonic seal to obtain its identity. The SPAR can compare the present identity with a previous identity, which it obtains from a magnetic bubble cassette memory. A system has been developed which allows an IAEA inspector to transfer seal information obtained at a facility by the SPAR to an IAEA-based data storage and retrieval system, using the bubble cassette memory. Likewise, magnetic bubbles can be loaded at the IAEA with seal signature data needed at a facility for comparison purposes. The archived signatures can be retrieved from the data base for relevant statistical manipulation and for plotting

The Significance of Critical Incidents and Voice to Identity and Agency

Science.gov (United States)

Sisson, Jamie Huff

2016-01-01

Human agency is significant to the understanding of professional identities and actions. It is through human agency that individuals can become powerful in changing or authoring their own identities. Stemming from a larger narrative inquiry focused on understanding the professional identities of public preschool teachers, this paper draws on…

Apparent Amnesia : interidentity memory functioning in dissociative identity disdorder

OpenAIRE

Huntjens, R.J.C.

2003-01-01

Dissociative identity disorder (DID) is characterized by the presence of two or more distinct identities or personality states that recurrently take control of the individual s behavior. Between 95 and 100 % of DID patients report experiences of blank spells for periods of time when other identities are in control of their behavior. In this thesis, the fundamental question of whether objective evidence for the reported interidentity amnesia in DID can be found under rigorous experimental cond...

Soviet Jewish Community Strategies, Concerning Memory Perpetuation (Erection of Memorials to Jews-Fascism Victims Case Study

Directory of Open Access Journals (Sweden)

Alexandra Tcherkasski

2013-09-01

Full Text Available The article, case studying the memorials erection, shows the process of Jews, victims of Nazism memory perpetuation by the Jewish Community within the Soviet Republics in postwar, what difficulties the Jewish Communities and groups of initiators faced, trying to prove the Jewish identity of the graves and gain adoption of Jewish symbols on memorials and memorial signs to fascism victims.

Identidad y memoria urbana. Recuerdo y olvido, continuidades y discontinuidades en la ciudad. / Urban identity and memory. Remembering and forgetting, continuities and discontinuities in the city.

Directory of Open Access Journals (Sweden)

López G., Loreto

2004-06-01

Full Text Available El interés por las dimensiones simbólicas de la vida urbana, incorpora un conjunto de interrogantes vinculadas a las nociones de cultura e identidad, que han estado relativamente ausentes en la reflexión sobre la ciudad. Para abordar los problemas relativos a la construcción de la identidad en el contexto urbano, habría variados accesos. En esta ocasión se presenta al patrimonio, en tanto "lugar de memoria", como un fenómeno acotado que permite introducirse en las relaciones simbólicas que establecen los habitantes con determinado espacio, con el fin de sacralizar su memoria y representar su identidad./The symbolic dimensions of urban life, that include matters concerning culture and identity, have been absent when reflecting upon the city. There are many ways to approach the problems concerning the "construction of identity" in an urban context. In this paper the built heritage is presented not only as a "place of memory", also it is a fixed phenomenon that allow us to look at symbolic relations that the people establish with their space, thus dubbing their memory as something sacred and representing their identity.

Navigating the transition to college: First-generation undergraduates negotiate identities and search for success in STEM and non-STEM fields

Science.gov (United States)

Mussey, Season Shelly

2009-12-01

Historically, racial and ethnic minority students from low income backgrounds have faced unequal access to colleges and universities. Recently, both K-12 and higher education institutions, specifically the University of California, in response to Proposition 209, have made efforts to increase access and opportunities for all students. Similarly, female minority students are underrepresented in selected science, technology, engineering and math (STEM) majors and careers. Using a qualitative research design, this study investigates how first generation, low income, underrepresented minority students who graduated from an innovative college preparatory high school enact coping strategies that they were explicitly taught to achieve success within the context of university science and math courses. The presence of a unique, college-prep high school on the campus of UC San Diego, which accepts exclusively low-income students through a randomized lottery system, creates an unusual opportunity to study the transition from high school to college for this population, a cohort of underrepresented students who were taught similar academic coping strategies for success in college. This study aims to understand how students develop their college-going, academic identities within the context of their colleges and universities. Furthermore, this study intends to understand the phenomenon of "transition to college" as a lived experience of first-generation, low income, minority students, who all share a similar college preparatory, high school background. The main research questions are: (1) How do underrepresented students experience the transition from a college preparatory high school to college? (2) How are students developing their college-going, academic identities in the context of their educational institutions? and (3) What factors support or constrain student participation and success in college science courses? Twenty-eight students participated in this study. Based on

Memory design

DEFF Research Database (Denmark)

Tanderup, Sisse

by cultural forms, often specifically by the concept of memory in philosophy, sociology and psychology, while Danish design traditionally has been focusing on form and function with frequent references to the forms of nature. Alessi's motivation for investigating the concept of memory is that it adds......Mind and Matter - Nordik 2009 Conference for Art Historians Design Matters Contributed Memory design BACKGROUND My research concerns the use of memory categories in the designs by the companies Alessi and Georg Jensen. When Alessi's designers create their products, they are usually inspired...... a cultural dimension to the design objects, enabling the objects to make an identity-forming impact. Whether or not the concept of memory plays a significant role in Danish design has not yet been elucidated fully. TERMINOLOGY The concept of "memory design" refers to the idea that design carries...

Islamic Myths and Memories

DEFF Research Database (Denmark)

Islamic myths and collective memory are very much alive in today’s localized struggles for identity, and are deployed in the ongoing construction of worldwide cultural networks. This book brings the theoretical perspectives of myth-making and collective memory to the study of Islam and globalizat....... It shows how contemporary Islamic thinkers and movements respond to the challenges of globalization by preserving, reviving, reshaping, or transforming myths and memories....

Stem cell self-renewal in intestinal crypt

NARCIS (Netherlands)

Simons, B.D.; Clevers, H.

2011-01-01

As a rapidly cycling tissue capable of fast repair and regeneration, the intestinal epithelium has emerged as a favored model system to explore the principles of adult stem cell biology. However, until recently, the identity and characteristics of the stem cell population in both the small intestine

War Memories and the Refusal of Male Dominance in Shakir's "Oh, Lebanon"

Science.gov (United States)

Al-Momani, Hassan Ali Abdullah

2017-01-01

This study investigates the role of the war memories in the construction of the female gender identity in Evelyin Shakir's "Oh, Lebanon," in which the female protagonist refuses to belong to her Arab identity when she lives in the United States because of the brutal war memories she witnesses in Lebanon. Such memories make the…

High School Students' Perception of University Students as STEM Representatives

DEFF Research Database (Denmark)

Poulsen, Eva Lykkegaard

The Danish government has an ambition to recruit more high school students into STEM edu-cations (science, technology, engineering and/or mathematics). The students’ choice of further education is based on the people and jobs they have knowledge of. Therefore, to recruit more students into STEM....... Some representatives transmit infor-mation and are thereby definers, whereas other representatives illustrates as personal examples and are thereby models. This study focuses on high school students’ views on STEM representatives and the impact these representatives have on the high school students...... studies, it is important to introduce high school students to good STEM representatives to make possible the development of potential STEM identities. A potential identity within a specific subject area relies on at least a situation bound relation-ship to the subject area or the person representing it...

ID-Check: Online Concealed Information Test Reveals True Identity.

Science.gov (United States)

Verschuere, Bruno; Kleinberg, Bennett

2016-01-01

The Internet has already changed people's lives considerably and is likely to drastically change forensic research. We developed a web-based test to reveal concealed autobiographical information. Initial studies identified a number of conditions that affect diagnostic efficiency. By combining these moderators, this study investigated the full potential of the online ID-check. Participants (n = 101) tried to hide their identity and claimed a false identity in a reaction time-based Concealed Information Test. Half of the participants were presented with personal details (e.g., first name, last name, birthday), whereas the others only saw irrelevant details. Results showed that participants' true identity could be detected with high accuracy (AUC = 0.98; overall accuracy: 86-94%). Online memory detection can reliably and validly detect whether someone is hiding their true identity. This suggests that online memory detection might become a valuable tool for forensic applications. © 2015 American Academy of Forensic Sciences.

Structural identity of the pluripotential hemopoietic stem cell

NARCIS (Netherlands)

Bekkum, D.W. van; Engh, G.J. van den; Wagemaker, G.

1979-01-01

A review is presented of the experiments that resulted in the identification of a specific morphologic entity representing the pluripotential hemopoietic stem cell (HSC) in mouse bone marrow. This entity was subsequently discovered in concentrated HSC preparations from bone marrow of rats, monkeys,

The experiences of Panamanian Afro-Caribbean women in STEM: Voices to inform work with Black females in STEM education

Science.gov (United States)

Miller, Beverly A. King

This grounded theory case study examines the experiences of Panamanian Afro-Caribbean women and their membership in STEM (Science, Technology, Engineering and Mathematics) training and careers. The shortage of Science and Math teachers in 48 of 50 States heightens the need for those trained in STEM. Females of African phenotype have persistently been underrepresented in STEM. However, this trend does not appear to have held for Panamanian Afro-Caribbean women. The current study explores issues related to STEM participation for these women by addressing the overarching question: What key factors from the lived experiences of Panamanian Afro-Caribbean women in STEM careers can be used to inform work with females of African phenotype in their pursuit of STEM education and STEM careers? Five women were identified for inclusion in the study's purposive sample. The study draws upon assertions and implications about the relevance of self-identity and collective-identity for membership in STEM. Data for the study was gathered through qualitative interviews, surveys, and observations. The grounded theory approach was used to analyze emergent themes related to participants' responses to the research questions. Two models, the STEM Attainment Model (SAM) and the Ecological Model of Self-Confidence and Bi-Directional Effect, are proposed from evaluation of the identified information. Socio-cultural values and learned strategies were determined to influence self-confidence which is identified as important for persistence in STEM training and careers for females of African phenotype. Evidence supports that the influences of parents, country of origin, neighborhood communities, schools and teachers are factors for persistence. Through the voices of these women, recommendations are offered to the gatekeepers of STEM academic pathways and ultimately STEM careers.

Dissociative identity disorder: a controversial diagnosis.

Science.gov (United States)

Gillig, Paulette Marie

2009-03-01

A brief description of the controversies surrounding the diagnosis of dissociative identity disorder is presented, followed by a discussion of the proposed similarities and differences between dissociative identity disorder and borderline personality disorder. The phenomenon of autohypnosis in the context of early childhood sexual trauma and disordered attachment is discussed, as is the meaning of alters or alternate personalities. The author describes recent neurosciences research that may relate the symptoms of dissociative identity disorder to demonstrable disordered attention and memory processes. A clinical description of a typical patient presentation is included, plus some recommendations for approaches to treatment.

Memory and Identity in the Emotive Map of Alain Resnais’ Hiroshima Mon Amour (1959

Directory of Open Access Journals (Sweden)

Jytte Holmqvist

2014-11-01

Full Text Available The focus of this article is Alain Resnais’ representation of collective and individual memory and identity in Hiroshima Mon Amour (1959. The film is based on Marguerite Duras’ script from 1958 and remains faithful to this original text. With partial reference to Giuliana Bruno’s views on imaginary cities and urban cartography, the screened urban space will here be read as an emotive map in which the individual love story between the protagonists unfolds against the backdrop of their almost equally intimate relationship with the historically abused city of Hiroshima. This, in Bruno’s words helps create an affective “map of love” (243 or a “body-city on a tender map” (242. The paper highlights the fluid relationship between the protagonists and their environment, as well as the semi-documentary aspects of a film that establishes an effective dialogue between past and present.

Memory transfer for emotionally valenced words between identities in dissociative identity disorder

NARCIS (Netherlands)

Huntjens, Rafaele J. C.; Peters, Madelon L.; Woertman, Liesbeth; van der Hart, Onno; Postma, Albert

The present study aimed to determine interidentity retrieval of emotionally valenced words in dissociative identity disorder (DID). Twenty-two DID patients participated together with 25 normal controls and 25 controls instructed to simulate DID. Two wordlists A and B were constructed including

Staged Memories: Spanish Drama and Cinema, Andalusian Identity and Flamenco Music in Argentina and Mexico

Directory of Open Access Journals (Sweden)

Emilio J. Gallardo-Saborido

2015-09-01

Full Text Available Culture, particularly cinema, drama and music, played a key role in order to keep and reinforce the identity of Spanish migrants in Argentina and Mexico during the first part of the 20th century. For decades, these countries had received thousands of migrants from Spain, and by the period following the Spanish Civil War (1936-1939 a notable colony of them settled in Buenos Aires and Mexico City. At the same time, several artists arrived to these places escaping from the war, political repression or, simply, looking for new work opportunities. For instance, famous singers, actors and flamenco players and dancers (v.g. Miguel de Molina, Angelillo, Niño de Utrera, or Sabicas achieved overwhelming successes in Buenos Aires and Mexico City’s theatres. Even more, they created a parallel Spanish stardom abroad. Hence, this proposal summarizes the contribution of some of these artists and the fusion between theatre and cinema, and typical Andalusian music as flamenco to preserve and evoke the collective memory of such a faraway motherland. Since Andalusia (the Southern region of Spain and its culture acted as a metonymic resource to represent that country during that period, migrants from different regions could recognize a common notion of the Spanish identity in them. In this sense, ‘home’ could be staged, remembered, fictionalized and, obviously, idealized.

Translational applications of adult stem cell-derived organoids

NARCIS (Netherlands)

Drost, Jarno; Clevers, Hans

2017-01-01

Adult stem cells from a variety of organs can be expanded long-term in vitro as three-dimensional organotypic structures termed organoids. These adult stem cell-derived organoids retain their organ identity and remain genetically stable over long periods of time. The ability to grow organoids from

Positive and Negative Childhood and Adolescent Identity Memories Stemming from One's Country and Culture-of-Origin: A Comparative Narrative Analysis

Science.gov (United States)

Bazuin-Yoder, Amy

2011-01-01

The initial cognitive ability to coordinate experience into a hierarchically organized, multi-episode narrative occurs in youth, beginning a narrative record of ego identity development that continues throughout the life span (Habermas and Bluck in "Psychological Bulletin" 126:748-769, 2000; Habermas and de Silveira in "Developmental Psychology"…

Autobiographical Memory Specificity in Dissociative Identity Disorder

NARCIS (Netherlands)

Huntjens, R.J.C.; Wessel, I.; Hermans, D.; Minnen, A. van

2014-01-01

A lack of adequate access to autobiographical knowledge has been related to psychopathology. More specifically, patients suffering from depression or a history of trauma have been found to be characterized by overgeneral memory, in other words, they show a relative difficulty in retrieving a

Autobiographical memory specificity in dissociative identity disorder

NARCIS (Netherlands)

Huntjens, Rafaële J. C.; Wessel, Ineke; Hermans, Dirk; van Minnen, Agnes

A lack of adequate access to autobiographical knowledge has been related to psychopathology. More specifically, patients suffering from depression or a history of trauma have been found to be characterized by overgeneral memory, in other words, they show a relative difficulty in retrieving a

Remembering who was where: A happy expression advantage for face identity-location binding in working memory.

Science.gov (United States)

Spotorno, Sara; Evans, Megan; Jackson, Margaret C

2018-04-19

It is well established that visual working memory (WM) for face identity is enhanced when faces display threatening versus nonthreatening expressions. During social interaction, it is also important to bind person identity with location information in WM to remember who was where, but we lack a clear understanding of how emotional expression influences this. Here, we conducted two touchscreen experiments to investigate how angry versus happy expressions displayed at encoding influenced the precision with which participants relocated a single neutral test face to its original position. Maintenance interval was manipulated (Experiment 2; 1 s, 3 s, 6 s) to assess durability of binding. In both experiments, relocation accuracy was enhanced when faces were happy versus angry, and this happy benefit endured from 1-s to 6-s maintenance interval. Eye movement measures during encoding showed no convincing effects of oculomotor behavior that could readily explain the happy benefit. However, accuracy in general was improved, and the happy benefit was strongest for the last, most recent face fixated at encoding. Improved, durable binding of who was where in the presence of a happy expression may reflect the importance of prosocial navigation. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Ambos lados: deconstructing identity, performing memory

OpenAIRE

Marín Ezpeleta, Rakel; Daniel, Henry

2015-01-01

Project Barca’s central research question – how can embodied personal and collective memories be shaped into new architectures of identityand belonging in the form of innovative performance works that speak to wider sections of society? – has so far generated a number of mixed-media performance outcomes in its two research locations; Barcelona, Catalonia, and Vancouver, Canada. Some major works are the video essay Encounters 3; Barca-El otro lado – a performance work that utilizes dancers, ac...

Arla and Danish National Identity

DEFF Research Database (Denmark)

Mordhorst, Mads

2014-01-01

into modernity that is more democratic than the traditional process of industrialisation seen in other European countries. Thus the narrative of the co-operatives has become part of Danish memory and identity. In the post-war years, however, and especially in the last two decades, the process of globalisation...

Dissociating word stem completion and cued recall as a function of divided attention at retrieval.

Science.gov (United States)

Clarke, A J Benjamin; Butler, Laurie T

2008-10-01

The aim of this study was to investigate the widely held, but largely untested, view that implicit memory (repetition priming) reflects an automatic form of retrieval. Specifically, in Experiment 1 we explored whether a secondary task (syllable monitoring), performed during retrieval, would disrupt performance on explicit (cued recall) and implicit (stem completion) memory tasks equally. Surprisingly, despite substantial memory and secondary costs to cued recall when performed with a syllable-monitoring task, the same manipulation had no effect on stem completion priming or on secondary task performance. In Experiment 2 we demonstrated that even when using a particularly demanding version of the stem completion task that incurred secondary task costs, the corresponding disruption to implicit memory performance was minimal. Collectively, the results are consistent with the view that implicit memory retrieval requires little or no processing capacity and is not seemingly susceptible to the effects of dividing attention at retrieval.

Clinical Perspectives on Autobiographical Memory

DEFF Research Database (Denmark)

Autobiographical memory plays a key role in psychological well-being, and the field has been investigated from multiple perspectives for more than thirty years. One large body of research has examined the basic mechanisms and characteristics of autobiographical memory during general cognition......, and another body has studied what happens to it during psychological disorders, and how psychological therapies targeting memory disturbances can improve psychological well-being. This edited collection reviews and integrates current theories on autobiographical memory when viewed in a clinical perspective....... It presents an overview of basic applied and clinical approaches to autobiographical memory, covering memory specificity, traumatic memories, involuntary and intrusive memories, and the role of self-identity. The book discusses a wide range of psychological disorders, including depression, posttraumatic...

Mammary gland stem cells

DEFF Research Database (Denmark)

Fridriksdottir, Agla J R; Petersen, Ole W; Rønnov-Jessen, Lone

2011-01-01

Distinct subsets of cells, including cells with stem cell-like properties, have been proposed to exist in normal human breast epithelium and breast carcinomas. The cellular origins of epithelial cells contributing to gland development, tissue homeostasis and cancer are, however, still poorly...... and differences between mouse and human gland development with particular emphasis on the identity and localization of stem cells, and the influence of the surrounding microenvironment. It is concluded that while recent advances in the field have contributed immense insight into how the normal mammary gland...... develops and is maintained, significant discrepancies exist between the mouse and human gland which should be taken into consideration in current and future models of mammary stem cell biology....

Pleasantness bias in flashbulb memories: positive and negative flashbulb memories of the fall of the Berlin Wall among East and West Germans.

Science.gov (United States)

Bohn, Annette; Berntsen, Dornhe

2007-04-01

Flashbulb memories for the fall of the Berlin Wall were examined among 103 East and West Germans who considered the event as either highly positive or highly negative. The participants in the positive group rated their memories higher on measures of reliving and sensory imagery, whereas their memory for facts was less accurate than that of the participants in the negative group. The participants in the negative group had higher ratings on amount of consequences but had talked less about the event and considered it less central to their personal and national identity than did the participants in the positive group. In both groups, rehearsal and the centrality of the memory to the person's identity and life story correlated positively with memory qualities. The results suggest that positive and negative emotions have different effects on the processing and long-term retention of flashbulb memories.

Short-term memory and dual task performance

Science.gov (United States)

Regan, J. E.

1982-01-01

Two hypotheses concerning the way in which short-term memory interacts with another task in a dual task situation are considered. It is noted that when two tasks are combined, the activity of controlling and organizing performance on both tasks simultaneously may compete with either task for a resource; this resource may be space in a central mechanism or general processing capacity or it may be some task-specific resource. If a special relationship exists between short-term memory and control, especially if there is an identity relationship between short-term and a central controlling mechanism, then short-term memory performance should show a decrement in a dual task situation. Even if short-term memory does not have any particular identity with a controlling mechanism, but both tasks draw on some common resource or resources, then a tradeoff between the two tasks in allocating resources is possible and could be reflected in performance. The persistent concurrence cost in memory performance in these experiments suggests that short-term memory may have a unique status in the information processing system.

Interference in memory for tonal pitch: implications for a working-memory model.

Science.gov (United States)

Pechmann, T; Mohr, G

1992-05-01

The degree of interference caused by different kinds of stimuli on memory for tonal pitch was studied. Musically trained and untrained subjects heard a sequence of two tones separated by an interval of 5 sec. The tones were either identical in pitch or differed by a semitone. Subjects had to decide whether the tones were identical or not. The interval was filled with tonal, verbal, or visual material under attended and unattended conditions. The results revealed clear group differences. Musically trained subjects' retention of the first test tone was only affected by the interposition of other tones. In contrast, the performance of musically untrained subjects was also affected by verbal and visual items. The findings are discussed in the framework of Baddeley's (1986) working-memory model.

Stillbirth and stigma: the spoiling and repair of multiple social identities.

Science.gov (United States)

Brierley-Jones, Lyn; Crawley, Rosalind; Lomax, Samantha; Ayers, Susan

This study investigated mothers' experiences surrounding stillbirth in the United Kingdom, their memory making and sharing opportunities, and the effect these opportunities had on them. Qualitative data were generated from free text responses to open-ended questions. Thematic content analysis revealed that "stigma" was experienced by most women and Goffman's (1963) work on stigma was subsequently used as an analytical framework. Results suggest that stillbirth can spoil the identities of "patient," "mother," and "full citizen." Stigma was reported as arising from interactions with professionals, family, friends, work colleagues, and even casual acquaintances. Stillbirth produces common learning experiences often requiring "identity work" (Murphy, 2012). Memory making and sharing may be important in this work and further research is needed. Stigma can reduce the memory sharing opportunities for women after stillbirth and this may explain some of the differential mental health effects of memory making after stillbirth that is documented in the literature.

Identity approach in translation : sociocultural implications

Directory of Open Access Journals (Sweden)

Alicja Żuchelkowska

2012-01-01

Full Text Available The objective of this text consists in presenting how it is necessary for contemporary translators and interpreters (both literary and specialised to acquire and develop the ability to recognize elements of identity discourse in translated texts. Nowadays, the need for inter-cultural exchange is inevitably connected with the necessity of establishing harmonious co-existence for numerous cultures and identities. Therefore, it is crucial to educate translators in a way that enables them to pay special attention to identity and cultural perturbations present in translated texts (culture and language hybridisation, multiple identity, cultural dislocation, presence in linguistic and political discourse of minority cultures, regardless of their genre or form. Such a strong emphasis on identity problems in the translation is especially relevant in the European context, where the attention of researchers and politicians directed at identity problems stemming from ethnical and cultural issues sets the framework for a new cultural paradigm that determines the future development of the Eu. Becoming acquainted with this paradigm which emphasises fl uency, identity unmarkedness and the new model of European collectivity is indispensable for a translator aspiring to become a true cultural mediator.

Visual short-term memory binding deficit in familial Alzheimer's disease.

Science.gov (United States)

Liang, Yuying; Pertzov, Yoni; Nicholas, Jennifer M; Henley, Susie M D; Crutch, Sebastian; Woodward, Felix; Leung, Kelvin; Fox, Nick C; Husain, Masud

2016-05-01

Long-term episodic memory deficits in Alzheimer's disease (AD) are well characterised but, until recently, short-term memory (STM) function has attracted far less attention. We employed a recently-developed, delayed reproduction task which requires participants to reproduce precisely the remembered location of items they had seen only seconds previously. This paradigm provides not only a continuous measure of localization error in memory, but also an index of relational binding by determining the frequency with which an object is misplaced to the location of one of the other items held in memory. Such binding errors in STM have previously been found on this task to be sensitive to medial temporal lobe (MTL) damage in focal lesion cases. Twenty individuals with pathological mutations in presenilin 1 or amyloid precursor protein genes for familial Alzheimer's disease (FAD) were tested together with 62 healthy controls. Participants were assessed using the delayed reproduction memory task, a standard neuropsychological battery and structural MRI. Overall, FAD mutation carriers were worse than controls for object identity as well as in gross localization memory performance. Moreover, they showed greater misbinding of object identity and location than healthy controls. Thus they would often mislocalize a correctly-identified item to the location of one of the other items held in memory. Significantly, asymptomatic gene carriers - who performed similarly to healthy controls on standard neuropsychological tests - had a specific impairment in object-location binding, despite intact memory for object identity and location. Consistent with the hypothesis that the hippocampus is critically involved in relational binding regardless of memory duration, decreased hippocampal volume across FAD participants was significantly associated with deficits in object-location binding but not with recall precision for object identity or localization. Object-location binding may therefore

Autobiographical memory in borderline personality disorder-A systematic review.

Science.gov (United States)

Bech, Morten; Elklit, Ask; Simonsen, Erik

2015-05-01

Borderline personality disorder is a severe psychiatric illness. A key feature of the disorder is a disorganized sense of self often referred to as identity diffusion. Autobiographical memory is memory for personal life events. One of the main functions of these memories is to enable us to understand who we are by connecting past, present and future experiences. It seems that autobiographical memory is in some way disrupted in individuals with borderline personality disorder. A systematic review is conducted looking at studies that focus on the potential connections. We find that although a number of studies have been published results remain inconsistent. Furthermore, we find that many of the studies suffer from inadequate designs particularly regarding the reported measures of autobiographical memory. We discuss potential links between personality functioning, identity diffusion, autobiographical memory and borderline personality disorder. Copyright © 2015 John Wiley & Sons, Ltd.

Holding in Mind Conflicting Information: Pretending, Working Memory, and Executive Control

Science.gov (United States)

Albertson, Kathleen; Shore, Cecilia

2008-01-01

Preschoolers' recall of the true and pretend identities of an object in pretense was examined along with a battery of executive functioning and working memory tasks. We expected that children would retain separate identities, as well as a link between them, after observing episodes of pretense, and that memory for pretense would be related to…

Erythroid differentiation of human induced pluripotent stem cells is independent of donor cell type of origin.

Science.gov (United States)

Dorn, Isabel; Klich, Katharina; Arauzo-Bravo, Marcos J; Radstaak, Martina; Santourlidis, Simeon; Ghanjati, Foued; Radke, Teja F; Psathaki, Olympia E; Hargus, Gunnar; Kramer, Jan; Einhaus, Martin; Kim, Jeong Beom; Kögler, Gesine; Wernet, Peter; Schöler, Hans R; Schlenke, Peter; Zaehres, Holm

2015-01-01

Epigenetic memory in induced pluripotent stem cells, which is related to the somatic cell type of origin of the stem cells, might lead to variations in the differentiation capacities of the pluripotent stem cells. In this context, induced pluripotent stem cells from human CD34(+) hematopoietic stem cells might be more suitable for hematopoietic differentiation than the commonly used fibroblast-derived induced pluripotent stem cells. To investigate the influence of an epigenetic memory on the ex vivo expansion of induced pluripotent stem cells into erythroid cells, we compared induced pluripotent stem cells from human neural stem cells and human cord blood-derived CD34(+) hematopoietic stem cells and evaluated their potential for differentiation into hematopoietic progenitor and mature red blood cells. Although genome-wide DNA methylation profiling at all promoter regions demonstrates that the epigenetic memory of induced pluripotent stem cells is influenced by the somatic cell type of origin of the stem cells, we found a similar hematopoietic induction potential and erythroid differentiation pattern of induced pluripotent stem cells of different somatic cell origin. All human induced pluripotent stem cell lines showed terminal maturation into normoblasts and enucleated reticulocytes, producing predominantly fetal hemoglobin. Differences were only observed in the growth rate of erythroid cells, which was slightly higher in the induced pluripotent stem cells derived from CD34(+) hematopoietic stem cells. More detailed methylation analysis of the hematopoietic and erythroid promoters identified similar CpG methylation levels in the induced pluripotent stem cell lines derived from CD34(+) cells and those derived from neural stem cells, which confirms their comparable erythroid differentiation potential. Copyright© Ferrata Storti Foundation.

Autobiographical memory decline in Alzheimer’s Disease

Science.gov (United States)

EL HAJ, Mohamad; Antoine, Pascal; Nandrino, Jean-Louis; Kapogiannis, Dimitrios

2016-01-01

Autobiographical memory, or memory for personal experiences, allows individuals to define themselves and construct a meaningful life story. Decline of this ability, as observed in Alzheimer’s Disease (AD), results in an impaired sense of self and identity. We present a critical review of theories and findings regarding cognitive and neuroanatomical underpinnings of autobiographical memory and its decline in AD and highlight studies on its clinical rehabilitation. We propose that autobiographical recall in AD is mainly characterized by loss of associated episodic information, which leads to de-contextualisation of autobiographical memories and a shift from reliving past events to a general sense of familiarity. This decline refers to retrograde, but also anterograde amnesia that affects newly acquired memories besides remote ones. One consequence of autobiographical memory decline in AD is decreased access to memories that shape self-consciousness, self-knowledge, and self-images, leading to a diminished sense of self and identity. The link between autobiographical decline and compromised sense of self in AD can also manifest itself as low correspondence and coherence between past memories and current goals and beliefs. By linking cognitive, neuroanatomical, and clinical aspects of autobiographical decline in AD, our review provides a theoretical foundation, which may lead to better rehabilitation strategies. PMID:26876367

The Unbearable Lightness of Memory: From Hamlet, Prince of Denmark to Jorge Luis Borges’ Shakespeare’s Memory

Directory of Open Access Journals (Sweden)

Raducanu Adriana

2015-12-01

Full Text Available The Romantic poet Novalis once rhetorically asked: “Where are we really going?” “Always home.” For a Shakespearean scholar like Borges’ Sörgel in “Shakespeare’s Memory”, the path towards “home” turns out to be the exploration of a most unusual gift, the very memory of the great Elizabethan. The process is similar although not identical in scope to Hamlet’s attempt to realign time through keeping alive the memory of his murdered father. My aim in this paper is to explore the process of preserving memory and its relation to identity, mourning and dread in “Hamlet, Prince of Denmark” and Borges’ “Shakespeare’s Memory”. The theoretical framework is defined by the concept of “eternal return”, as examined by Nietzsche and Mircea Eliade.

Specifics of the implicit expression of the author’s gender identity in 19th and 20th century German-language female memories

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Kessler L.A.

2018-01-01

Full Text Available this article covers the expression of implicit gender identity of the subject of speech activity in the 19th and 20th century women's memories. The study revealed that implicit gender aspects associated with linguistic ascertainment of gender stereotypes presented in female linguistic material form the lexico-semantic category of “Character”. Within this category, the lexico-semantic sub-categories “Emotionality”, “Fearfulness and diffidence” and “Dreaminess” play a significant role, representing the corresponding stereotypes.

Older, wiser, and happier? Comparing older adults' and college students' self-defining memories.

Science.gov (United States)

Singer, Jefferson; Rexhaj, Blerim; Baddeley, Jenna

2007-11-01

The present study compared self-defining memories in adults 50 years of age and older to the self-defining memories of college students. Findings are largely congruent with previous memory and ageing research, but shed additional light on how personal memories are employed to achieve a sense of identity and continuity in older adults. Older adults' self-defining memories, compared to those of younger adults, were more positive in emotional tone, more summarised and less detailed, and more likely to contain integrative meaning. The implications of these findings for assessing normative personal memory in older adults are discussed along with more general observations about narrative identity in older adulthood.

Oct4 targets regulatory nodes to modulate stem cell function.

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Pearl A Campbell

2007-06-01

Full Text Available Stem cells are characterized by two defining features, the ability to self-renew and to differentiate into highly specialized cell types. The POU homeodomain transcription factor Oct4 (Pou5f1 is an essential mediator of the embryonic stem cell state and has been implicated in lineage specific differentiation, adult stem cell identity, and cancer. Recent description of the regulatory networks which maintain 'ES' have highlighted a dual role for Oct4 in the transcriptional activation of genes required to maintain self-renewal and pluripotency while concomitantly repressing genes which facilitate lineage specific differentiation. However, the molecular mechanism by which Oct4 mediates differential activation or repression at these loci to either maintain stem cell identity or facilitate the emergence of alternate transcriptional programs required for the realization of lineage remains to be elucidated. To further investigate Oct4 function, we employed gene expression profiling together with a robust statistical analysis to identify genes highly correlated to Oct4. Gene Ontology analysis to categorize overrepresented genes has led to the identification of themes which may prove essential to stem cell identity, including chromatin structure, nuclear architecture, cell cycle control, DNA repair, and apoptosis. Our experiments have identified previously unappreciated roles for Oct4 for firstly, regulating chromatin structure in a state consistent with self-renewal and pluripotency, and secondly, facilitating the expression of genes that keeps the cell poised to respond to cues that lead to differentiation. Together, these data define the mechanism by which Oct4 orchestrates cellular regulatory pathways to enforce the stem cell state and provides important insight into stem cell function and cancer.

Optical quantum memory

Science.gov (United States)

Lvovsky, Alexander I.; Sanders, Barry C.; Tittel, Wolfgang

2009-12-01

Quantum memory is essential for the development of many devices in quantum information processing, including a synchronization tool that matches various processes within a quantum computer, an identity quantum gate that leaves any state unchanged, and a mechanism to convert heralded photons to on-demand photons. In addition to quantum computing, quantum memory will be instrumental for implementing long-distance quantum communication using quantum repeaters. The importance of this basic quantum gate is exemplified by the multitude of optical quantum memory mechanisms being studied, such as optical delay lines, cavities and electromagnetically induced transparency, as well as schemes that rely on photon echoes and the off-resonant Faraday interaction. Here, we report on state-of-the-art developments in the field of optical quantum memory, establish criteria for successful quantum memory and detail current performance levels.

CONSIDERATIONS ON CULTURAL MEMORY AND ITS INSTITUTIONALIZATION PROCESS

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Simona Mitroiu

2014-07-01

Full Text Available This study emphasizes the connection between the sites of memory and thenational identity, having as main objective to highlight the institutionalization ofthe cultural memory. Two main sites of memory are analysed: the archive and thelibrary, as representative for the cultural memory.The ideological and politicalinfluences are also revealed. The final part of this paper points out new challengesin the global digital age.

Parading memory and re-member-ing conflict

DEFF Research Database (Denmark)

McQuaid, Sara Dybris

2017-01-01

In Northern Ireland, parades have long been important carriers of politico-cultural identities and collective memories, as well as arenas of struggle and conflict. Taking as its starting point that these contests over meaning are always framed by their contexts of articulation both in temporal...... and spatial terms, this article examines the role of parades in the current ‘post-conflict’ phase of the peace process as it plays out in a particular location, namely North Belfast. Using theories of cultural and collective memory and examples from republican and loyalist parades in North Belfast......, it is argued that there is fear of memory and identity collapse in particular communities on the margins of the peace process, leading to a conscious doubling of efforts to (re)articulate the hidden recesses of memory in the current transition. In this, the patterns of ‘competitive commemoration’ in parades...

A Study of the Experience of Female African-American Seventh Graders in a Science, Technology, Engineering, and Math (STEM) Afterschool Program

Science.gov (United States)

Hinds, Beverley Fiona

The purpose of this qualitative study was to determine what inspires or leads seventh-grade African-American girls toward an interest in STEM, to characterize and describe the context of an out-of-school STEM learning environment, explore the impact on the seventh- grade African-American girls who participated in the program as it relates to individual STEM identity, and identify personal and academic experiences of seventh-grade African- American girls that contribute to the discouragement or pursuit of science and math-related academic pathways and careers. Notable findings in this study included the following: 1. Participants were interested in STEM and able to identify both external and internal influences that supported their involvement and interest in STEM activities. External influences expanded and elevated exposure to STEM experiences. 2. The MJS program provided an opportunity for participants to overcome challenges related to science and math knowledge and skills in school. 3. The MJS program increased levels of interest in STEM for the participants. 4. All participants increased their capacity to demonstrate increased knowledge in STEM content as a result of the learning experiences within the MJS program, and participants transferred this knowledge to experiences outside of the program including school. 5. The STEM learning environment provided multiple opportunities for participants to meet high expectation and access to engaging activities within a supportive, well-managed setting. 6. The MJS program participants demonstrated behaviors related to building a STEM identity through the components described by Carlone and Johnson (2007), including recognition-internal and external acknowledgement of being a STEM person; competence-demonstrating an understanding of STEM content; and performance-publically exhibiting STEM knowledge and skills. The findings in this study suggested that African-American seventh-grade girls interested in STEM are inspired

The continuum of stem cell transdifferentiation: possibility of hematopoietic stem cell plasticity with concurrent CD45 expression.

Science.gov (United States)

Udani, V M

2006-02-01

Recent years have seen a surge of scientific research examining adult stem cell plasticity. For example, the hematopoietic stem cell has been shown to give rise to skin, respiratory epithelium, intestinal epithelium, renal epithelium, liver parenchyma, pancreas, skeletal muscle, vascular endothelium, myocardium, and central nervous system (CNS) neurons. The potential for such stem cell plasticity seems to be enhanced by stressors such as injury and neoplasia. Interestingly, recent studies have demonstrated that hematopoietic stem cells may be able to adopt certain nonhematopoietic phenotypes, such as endothelial, neural, or skeletal muscle phenotypes, without entirely losing their initial hematopoietic identity. We propose that transdifferentiation can, in certain conditions, be a partial rather than a complete event, and we encourage further investigation into the phenomenon of a stem cell simultaneously expressing phenotypic features of two distinct cell fates.

Individual differences in the ability to recognise facial identity are associated with social anxiety.

Science.gov (United States)

Davis, Joshua M; McKone, Elinor; Dennett, Hugh; O'Connor, Kirsty B; O'Kearney, Richard; Palermo, Romina

2011-01-01

Previous research has been concerned with the relationship between social anxiety and the recognition of face expression but the question of whether there is a relationship between social anxiety and the recognition of face identity has been neglected. Here, we report the first evidence that social anxiety is associated with recognition of face identity, across the population range of individual differences in recognition abilities. Results showed poorer face identity recognition (on the Cambridge Face Memory Test) was correlated with a small but significant increase in social anxiety (Social Interaction Anxiety Scale) but not general anxiety (State-Trait Anxiety Inventory). The correlation was also independent of general visual memory (Cambridge Car Memory Test) and IQ. Theoretically, the correlation could arise because correct identification of people, typically achieved via faces, is important for successful social interactions, extending evidence that individuals with clinical-level deficits in face identity recognition (prosopagnosia) often report social stress due to their inability to recognise others. Equally, the relationship could arise if social anxiety causes reduced exposure or attention to people's faces, and thus to poor development of face recognition mechanisms.

Temporal Progression of Retinal Progenitor Cell Identity: Implications in Cell Replacement Therapies

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Awais Javed

2017-12-01

Full Text Available Retinal degenerative diseases, which lead to the death of rod and cone photoreceptor cells, are the leading cause of inherited vision loss worldwide. Induced pluripotent or embryonic stem cells (iPSCs/ESCs have been proposed as a possible source of new photoreceptors to restore vision in these conditions. The proof of concept studies carried out in mouse models of retinal degeneration over the past decade have highlighted several limitations for cell replacement in the retina, such as the low efficiency of cone photoreceptor production from stem cell cultures and the poor integration of grafted cells in the host retina. Current protocols to generate photoreceptors from stem cells are largely based on the use of extracellular factors. Although these factors are essential to induce the retinal progenitor cell (RPC fate from iPSCs/ESCs, developmental studies have shown that RPCs alter fate output as a function of time (i.e., their temporal identity to generate the seven major classes of retinal cell types, rather than spatial position. Surprisingly, current stem cell differentiation protocols largely ignore the intrinsic temporal identity of dividing RPCs, which we argue likely explains the low efficiency of cone production in such cultures. In this article, we briefly review the mechanisms regulating temporal identity in RPCs and discuss how they could be exploited to improve cone photoreceptor production for cell replacement therapies.

Facial expression influences face identity recognition during the attentional blink.

Science.gov (United States)

Bach, Dominik R; Schmidt-Daffy, Martin; Dolan, Raymond J

2014-12-01

Emotional stimuli (e.g., negative facial expressions) enjoy prioritized memory access when task relevant, consistent with their ability to capture attention. Whether emotional expression also impacts on memory access when task-irrelevant is important for arbitrating between feature-based and object-based attentional capture. Here, the authors address this question in 3 experiments using an attentional blink task with face photographs as first and second target (T1, T2). They demonstrate reduced neutral T2 identity recognition after angry or happy T1 expression, compared to neutral T1, and this supports attentional capture by a task-irrelevant feature. Crucially, after neutral T1, T2 identity recognition was enhanced and not suppressed when T2 was angry-suggesting that attentional capture by this task-irrelevant feature may be object-based and not feature-based. As an unexpected finding, both angry and happy facial expressions suppress memory access for competing objects, but only angry facial expression enjoyed privileged memory access. This could imply that these 2 processes are relatively independent from one another.

Polycomb-group genes sustaining the stem cell activity

International Nuclear Information System (INIS)

Takihara, Yoshihiro

2006-01-01

Polycomb-group genes (PcG) have a role in constituting the cellular memory mechanisms through which the once expressed phenotypes during development are transmitted thereafter and this review describes, together with authors' findings of sustaining hematopoietic stem cell activity by the PcG products, what molecular bases, involving the control of histone code, are concerned in the memory. Recent investigations have gradually elucidated the outline of epigenetic control mechanisms of the memory: messages are set up as a histone code in the chromatin and the PcG complex recruited by recognition of the code regulates the chromatin structure leading to DNA transcription and maintenance of the phenotype. Proliferation of hematopoietic stem cells ex vivo will be possible if exact and detailed mechanisms for PcG are made clear in future. Such ex vivo techniques are especially awaited for marrow remodeling treatment of hematopoietic failure induced by radiation exposure. (T.I.)

Identity recognition in response to different levels of genetic relatedness in commercial soya bean

Science.gov (United States)

Van Acker, Rene; Rajcan, Istvan; Swanton, Clarence J.

2017-01-01

Identity recognition systems allow plants to tailor competitive phenotypes in response to the genetic relatedness of neighbours. There is limited evidence for the existence of recognition systems in crop species and whether they operate at a level that would allow for identification of different degrees of relatedness. Here, we test the responses of commercial soya bean cultivars to neighbours of varying genetic relatedness consisting of other commercial cultivars (intraspecific), its wild progenitor Glycine soja, and another leguminous species Phaseolus vulgaris (interspecific). We found, for the first time to our knowledge, that a commercial soya bean cultivar, OAC Wallace, showed identity recognition responses to neighbours at different levels of genetic relatedness. OAC Wallace showed no response when grown with other commercial soya bean cultivars (intra-specific neighbours), showed increased allocation to leaves compared with stems with wild soya beans (highly related wild progenitor species), and increased allocation to leaves compared with stems and roots with white beans (interspecific neighbours). Wild soya bean also responded to identity recognition but these responses involved changes in biomass allocation towards stems instead of leaves suggesting that identity recognition responses are species-specific and consistent with the ecology of the species. In conclusion, elucidating identity recognition in crops may provide further knowledge into mechanisms of crop competition and the relationship between crop density and yield. PMID:28280587

Stem cell self-renewal in intestinal crypt

International Nuclear Information System (INIS)

Simons, Benjamin D.; Clevers, Hans

2011-01-01

As a rapidly cycling tissue capable of fast repair and regeneration, the intestinal epithelium has emerged as a favored model system to explore the principles of adult stem cell biology. However, until recently, the identity and characteristics of the stem cell population in both the small intestine and colon has remained the subject of debate. Recent studies based on targeted lineage tracing strategies, combined with the development of an organotypic culture system, have identified the crypt base columnar cell as the intestinal stem cell, and have unveiled the strategy by which the balance between proliferation and differentiation is maintained. These results show that intestinal stem cells operate in a dynamic environment in which frequent and stochastic stem cell loss is compensated by the proliferation of neighboring stem cells. We review the basis of these experimental findings and the insights they offer into the mechanisms of homeostatic stem cell regulation.

An Informal Science Education Program's Impact on STEM Major and STEM Career Outcomes

Science.gov (United States)

Habig, Bobby; Gupta, Preeti; Levine, Brian; Adams, Jennifer

2018-04-01

While there is extensive evidence that STEM careers can be important pathways for augmenting social mobility and for increasing individual prestige, many youth perceive a STEM trajectory as an unattractive option. In the USA, women and members of historically marginalized racial and ethnic groups continue to be underrepresented across STEM disciplines. One vehicle for generating and sustaining interest in STEM is providing youth long-term access to informal science education (ISE) institutions. Here, we incorporate triangulation methods, collecting and synthesizing both qualitative and quantitative data, to examine how participation in a longitudinal ISE out-of-school time (OST) program facilitated by the American Museum of Natural History (AMNH) impacted the STEM trajectories of 66 alumni. Findings revealed that 83.2% of alumni engaged in a STEM major, and 63.1% in a STEM career, the majority whom were females and/or members of historically underrepresented racial and ethnic groups. Based on interviews with a purposeful sample of 21 AMNH alumni, we identified four program design principles that contributed to persistence in STEM: (1) affording multiple opportunities to become practitioners of science; (2) providing exposure to and repeated experiences with STEM professionals such as scientists, educators, and graduate students to build social networks; (3) furnishing opportunities for participants to develop shared science identities with like-minded individuals; and (4) offering exposure to and preparation for a variety of STEM majors and STEM careers so that youth can engage in discovering possible selves. These findings support our central thesis that long-term engagement in ISE OST programs fosters persistence in STEM.

Vocal caricatures reveal signatures of speaker identity

Science.gov (United States)

López, Sabrina; Riera, Pablo; Assaneo, María Florencia; Eguía, Manuel; Sigman, Mariano; Trevisan, Marcos A.

2013-12-01

What are the features that impersonators select to elicit a speaker's identity? We built a voice database of public figures (targets) and imitations produced by professional impersonators. They produced one imitation based on their memory of the target (caricature) and another one after listening to the target audio (replica). A set of naive participants then judged identity and similarity of pairs of voices. Identity was better evoked by the caricatures and replicas were perceived to be closer to the targets in terms of voice similarity. We used this data to map relevant acoustic dimensions for each task. Our results indicate that speaker identity is mainly associated with vocal tract features, while perception of voice similarity is related to vocal folds parameters. We therefore show the way in which acoustic caricatures emphasize identity features at the cost of loosing similarity, which allows drawing an analogy with caricatures in the visual space.

Gummed-up memory: Chewing gum impairs short-term recall

OpenAIRE

Kozlov, Michail D; Hughes, Robert W; Jones, Dylan M

2012-01-01

Several studies have suggested that short-term memory is generally improved by chewing gum. However, we report the first studies to show that chewing gum impairs short-term memory for both item order and item identity. Experiment 1 showed that chewing gum reduces serial recall of letter lists. Experiment 2 indicated that chewing does not simply disrupt vocal-articulatory planning required for order retention: Chewing equally impairs a matched task that required retention of list item identity...

Comparison of outcomes in hematological malignancies treated with haploidentical or HLA-identical sibling hematopoietic stem cell transplantation following myeloablative conditioning: A meta-analysis

Science.gov (United States)

Guo, Dan; Xu, Peipei; Chen, Bing

2018-01-01

Purpose Haploidentical and human leukocyte antigen (HLA)-identical sibling hematopoietic stem transplantation are two main ways used in allogeneic hematopoietic stem cell transplantation (allo-HSCT). In recent years, remarkable progress has been made in haploidentical allo-HSCT (HID-SCT), and some institutions found HID-SCT had similar outcomes as HLA-identical sibling allo-HSCT (ISD-SCT). To clarify if HID-SCT has equal effects to ISD-SCT in hematologic malignancies, we performed this meta-analysis. Methods Relevant articles published prior to February 2017 were searched on PubMed. Two reviewers assessed the quality of the included studies and extracted data independently. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated for statistical analysis. Results Seven studies including 1919 patients were included. The rate of platelet engraftment is significantly lower after HID-SCT versus ISD-SCT while there is no difference in neutrophil engraftment (OR = 2.58, 95% CI = 1.70–3.93, P SCT versus ISD-SCT (OR = 1.88, 95% CI = 1.42–2.49, P SCT group (OR = 0.70, 95% CI = 0.55–0.90, P = 0.005). The incidence rates of overall survival (OS) and disease-free-survival/leukemia-free survival/relapse-free survival (DFS/LFS/RFS) after ISD-SCT are all significantly superior to HID-SCT (OR = 1.32, 95% CI = 1.08–1.62, P = 0.006; OR = 1.25, 95% CI = 1.03–1.52, P = 0.02). There is no significant difference in transplantation related mortality (TRM) rate after HID-SCT and ISD-SCT. Conclusion After myeloablative conditioning, patients receiving ISD-SCT have a faster engraftment, lower acute GVHD and longer life expectancy compared to HID-SCT with GVHD prophylaxis (cyclosporine A, methotrexate, mycophenolate mofetil and antithymoglobulin; CsA + MTX + MMF + ATG). Currently, HID-SCT with GVHD prophylaxis (CsA + MTX + MMF + ATG) may not replace ISD-SCT when HLA-identical sibling donor available. PMID:29381772

Strategies for future histocompatible stem cell therapy

DEFF Research Database (Denmark)

Nehlin, Jan; Barington, Torben

2009-01-01

Stem cell therapy based on the safe and unlimited self-renewal of human pluripotent stem cells is envisioned for future use in tissue or organ replacement after injury or disease. A gradual decline of regenerative capacity has been documented among the adult stem cell population in some body organs...... during the aging process. Recent progress in human somatic cell nuclear transfer and inducible pluripotent stem cell technologies has shown that patient-derived nuclei or somatic cells can be reprogrammed in vitro to become pluripotent stem cells, from which the three germ layer lineages can be generated......, genetically identical to the recipient. Once differentiation protocols and culture conditions can be defined and optimized, patient-histocompatible pluripotent stem cells could be directed towards virtually every cell type in the human body. Harnessing this capability to enrich for given cells within...

Cellular memory and, hematopoietic stem cell aging

NARCIS (Netherlands)

Kamminga, Leonie M.; de Haan, Gerald

Hematopoietic stem cells (HSCs) balance self-renewal and differentiation in order to sustain lifelong blood production and simultaneously maintain the HSC pool. However, there is clear evidence that HSCs are subject to quantitative and qualitative exhaustion. In this review, we briefly discuss

Tissue-resident adult stem cell populations of rapidly self-renewing organs

NARCIS (Netherlands)

Barker, N.; Bartfeld, S.; Clevers, H.

2010-01-01

The epithelial lining of the intestine, stomach, and skin is continuously exposed to environmental assault, imposing a requirement for regular self-renewal. Resident adult stem cell populations drive this renewal, and much effort has been invested in revealing their identity. Reliable adult stem

Histoire, mémoire et identité nationale History, memory and national identity. A German triptych confronted by present-day social evolutions

Directory of Open Access Journals (Sweden)

Muriel Rambour

2009-06-01

Full Text Available La responsabilité morale et politique à l’égard du passé est toujours sous-jacente dans la culture politique allemande. Toute tentative destinée à penser l’identité nationale, à mettre à jour ses principales caractéristiques, se trouve confrontée à la prégnance d’une mémoire collective particulièrement lourde de sens et de conséquences. De récentes polémiques sur l’attitude à adopter face à l’histoire et à l’idée nationale montrent combien cet héritage est structurant dans la réflexion sur la problématique identitaire. Si l’histoire, la mémoire et l’identité semblent indissociables dans ce contexte spécifique, des aspirations à une certaine « normalité » se manifestent quant à la manière de vivre ce passé et de s’exprimer au présent. La chute du Mur de Berlin et la réunification ont replacé le thème de l’identité nationale au centre des débats, réactivant ainsi une forme de dilemme entre un sentiment de culpabilité devant l’histoire et le désir d’un rapport « normalisé » à la nation allemande. Les transformations dont l’Allemagne est le théâtre depuis la dernière décennie rendent toutefois nécessaire le maintien d’une vigilante attention. Une situation d’insécurité économique et sociale, associée au temps qui risque d’atténuer la vivacité de souvenirs pourtant lourds, rappellent que la mémoire conditionne aussi la manière dont une nation réunifiée se projette dans l’avenir et y vit son identité.The moral and political responsibility regarding the past always underlies German political culture. Any attempt to conceive national identity, to update its main features, is faced with the vividness of a meaningful, collective memory, fraught with consequences. Recent controversies about the way to deal with history and the national idea show the extent to which this heritage structures the reflection on identity problems. Though history, memory and

Beyond Knowledge and Skills: Rethinking the Development of Professional Identity during the STEM Doctorate

Science.gov (United States)

Hancock, Sally; Walsh, Elaine

2016-01-01

The science, technology, engineering, mathematics (STEM) doctorate is the established entry qualification for a scientific research career. However, contemporary STEM doctoral graduates assume increasingly diverse professional paths, with many forging non-academic careers. Using the UK as an example, the authors suggest that the STEM PhD fails to…

Autobiographical memory decline in Alzheimer’s Disease

OpenAIRE

EL HAJ, Mohamad; Antoine, Pascal; Nandrino, Jean-Louis; Kapogiannis, Dimitrios

2016-01-01

Autobiographical memory, or memory for personal experiences, allows individuals to define themselves and construct a meaningful life story. Decline of this ability, as observed in Alzheimer’s Disease (AD), results in an impaired sense of self and identity. We present a critical review of theories and findings regarding cognitive and neuroanatomical underpinnings of autobiographical memory and its decline in AD and highlight studies on its clinical rehabilitation. We propose that autobiographi...

Age, memory type, and the phenomenology of autobiographical memory: findings from an Italian sample.

Science.gov (United States)

Montebarocci, Ornella; Luchetti, Martina; Sutin, Angelina R

2014-01-01

The present research explored differences in phenomenology between two types of memories, a general self-defining memory and an earliest childhood memory. A sample of 76 Italian participants were selected and categorised into two age groups: 20-30 years and 31-40 years. The Memory Experiences Questionnaire (MEQ) was administered, taking note of latency and duration times of the narratives. Consistent with the literature, the self-defining memory differed significantly from the earliest childhood memory in terms of phenomenology, with the recency of the memory associated with more intense phenomenological experience. The self-defining memory took longer to retrieve and narrate than the earliest childhood memory. Meaningful differences also emerged between the two age groups: Participants in their 30s rated their self-defining memory as more vivid, coherent, and accessible than participants in their 20s. According to latency findings, these differences suggest an expanded period of identity consolidation for younger adults. Further applications of the MEQ should be carried out to replicate these results with other samples of young adults.

Assessing the impact of Native American elders as co-educators for university students in STEM

Science.gov (United States)

Alkholy, Sarah Omar

Introduction: Minorities are underrepresented in the science, technology, engineering, and mathematics (STEM) workforce, post-secondary STEM education, and show high academic attrition rates. Academic performance and retention improve when culturally relevant support is provided. The interface of Western Science and Indigenous Science provides an opportunity for bridging this divide. This three parts project is an example of Community-based participatory research (CBPR) that aims to support academic institutions that serve minority students in STEM, and implement educational components (pedagogy) to serve the needs of the underserved community. Method: Part 1: was a cross-sectional used a survey given to participants designed to assess prevalence of natural health products use by students, and to determine how students learn about NHPs. Part 2: was a longitudinal survey pilot study based upon an online STEM course offer at four universities to determine the differences between U.S. vs. Canadian and minority vs. non-minority university students regarding their perceptions of traditional Elders as STEM co-educators, interest in STEM, and science identity by using a pre-and post- course survey. Part 3: was a longitudinal quasi-experiment based upon an online STEM course offered at four universities show what Indigenous science claims regarding: Elders are viewed as valuable STEM co-educators; Elders increase student interest in STEM; students exposed to Indigenous science improve their identity as a scientist; students exposed to Indigenous Science/Elders show improved learning outcomes. Result: We found that Native/Aboriginal students learn information about natural health products from traditional Elders significantly more so than non-Native/Aboriginal students. There were no statistically significant results from the pilot study. Findings from the quasi-experiment show that students taught with Indigenous science Elder co-educators have significantly greater

Monuments of memory: defensive mechanisms of the collective psyche and their manifestation in the memorialization process.

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Kalinowska, Malgorzata

2012-09-01

The paper searches for insight in the area of collective memory as a part of collective consciousness, a phenomenon understood as a stabilizing factor for a society's self-image and identity. Collective memories are seen as originating from shared communications transmitting and creating the meaning of the past in the form of narrative, symbols and signs. As such, they contain the individual, embodied and lived side of our relations to the past. As well as the identity-building and meaning-making functions of collective memories, their defensive function is discussed with a focus on commemorative practices taking place in a transitional space between psychic and social life. Fears of a lack of collective identity and coherence have contributed to the way Polish commemorative practices have been shaped. This is considered in relation to the Smolensk catastrophe in 2010, viewed in the context of the Jungian concept of the collective psyche and the psychoanalytical understanding of defensive group mechanisms against trauma, especially those relating to loss and mourning. It leads to a consideration of how historical experiences and the experience of history can be accessed, as well as their meaning for individual and group development. © 2012, The Society of Analytical Psychology.

Gummed-up memory: chewing gum impairs short-term recall.

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Kozlov, Michail D; Hughes, Robert W; Jones, Dylan M

2012-01-01

Several studies have suggested that short-term memory is generally improved by chewing gum. However, we report the first studies to show that chewing gum impairs short-term memory for both item order and item identity. Experiment 1 showed that chewing gum reduces serial recall of letter lists. Experiment 2 indicated that chewing does not simply disrupt vocal-articulatory planning required for order retention: Chewing equally impairs a matched task that required retention of list item identity. Experiment 3 demonstrated that manual tapping produces a similar pattern of impairment to that of chewing gum. These results clearly qualify the assertion that chewing gum improves short-term memory. They also pose a problem for short-term memory theories asserting that forgetting is based on domain-specific interference given that chewing does not interfere with verbal memory any more than tapping. It is suggested that tapping and chewing reduce the general capacity to process sequences.

Collective Memory and Collective Identity of Hlučín Region Inhabitants in the 20th Century

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Helena Kubátová

2016-06-01

Full Text Available The Hlučín Region is a small border area in the Moravia-Silesia Region. Its history is specific. Over 25 years in the 20th century, its border shifted three times and its inhabitants’ nationality also changed three times. The region was annexed by the German Reich in 1938 and its inhabitants gained the rights of citizens of the Reich, with the obligation to enlist in the Wehrmacht, the armed forces of Germany. These historical turning points and their consequences after the Second World War are part of the cultural and communicative memory of most of the local people. The purpose of the article is to show the communicative memory of Hlučín Region inhabitants and the common knowledge of 20th century historical events to be one of the important integral parts of regional identity, which is a source of regional consciousness. Hlučín Region inhabitants identify themselves strongly with their region and society. This identification results from specific culture finding its expression in shared values, faith and traditions, and from the awareness of their own specificity. As a consequence of the predominant regional endogamy, this culture is handed down from one generation to another. Strong regional consciousness based on this identification, has a positive influence on the rich communal life and possibilities of stabilization and further development of the region.

Individual differences in the ability to recognise facial identity are associated with social anxiety.

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Joshua M Davis

Full Text Available Previous research has been concerned with the relationship between social anxiety and the recognition of face expression but the question of whether there is a relationship between social anxiety and the recognition of face identity has been neglected. Here, we report the first evidence that social anxiety is associated with recognition of face identity, across the population range of individual differences in recognition abilities. Results showed poorer face identity recognition (on the Cambridge Face Memory Test was correlated with a small but significant increase in social anxiety (Social Interaction Anxiety Scale but not general anxiety (State-Trait Anxiety Inventory. The correlation was also independent of general visual memory (Cambridge Car Memory Test and IQ. Theoretically, the correlation could arise because correct identification of people, typically achieved via faces, is important for successful social interactions, extending evidence that individuals with clinical-level deficits in face identity recognition (prosopagnosia often report social stress due to their inability to recognise others. Equally, the relationship could arise if social anxiety causes reduced exposure or attention to people's faces, and thus to poor development of face recognition mechanisms.

A preclinical murine model for the early detection of radiation-induced brain injury using magnetic resonance imaging and behavioral tests for learning and memory: with applications for the evaluation of possible stem cell imaging agents and therapies.

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Ngen, Ethel J; Wang, Lee; Gandhi, Nishant; Kato, Yoshinori; Armour, Michael; Zhu, Wenlian; Wong, John; Gabrielson, Kathleen L; Artemov, Dmitri

2016-06-01

Stem cell therapies are being developed for radiotherapy-induced brain injuries (RIBI). Magnetic resonance imaging (MRI) offers advantages for imaging transplanted stem cells. However, most MRI cell-tracking techniques employ superparamagnetic iron oxide particles (SPIOs), which are difficult to distinguish from hemorrhage. In current preclinical RIBI models, hemorrhage occurs concurrently with other injury markers. This makes the evaluation of the recruitment of transplanted SPIO-labeled stem cells to injury sites difficult. Here, we developed a RIBI model, with early injury markers reflective of hippocampal dysfunction, which can be detected noninvasively with MRI and behavioral tests. Lesions were generated by sub-hemispheric irradiation of mouse hippocampi with single X-ray beams of 80 Gy. Lesion formation was monitored with anatomical and contrast-enhanced MRI and changes in memory and learning were assessed with fear-conditioning tests. Early injury markers were detected 2 weeks after irradiation. These included an increase in the permeability of the blood-brain barrier, demonstrated by a 92 ± 20 % contrast enhancement of the irradiated versus the non-irradiated brain hemispheres, within 15 min of the administration of an MRI contrast agent. A change in short-term memory was also detected, as demonstrated by a 40.88 ± 5.03 % decrease in the freezing time measured during the short-term memory context test at this time point, compared to that before irradiation. SPIO-labeled stem cells transplanted contralateral to the lesion migrated toward the lesion at this time point. No hemorrhage was detected up to 10 weeks after irradiation. This model can be used to evaluate SPIO-based stem cell-tracking agents, short-term.

A regulatory network of Drosophila germline stem cell self-renewal

OpenAIRE

Yan, Dong; Neumüller, Ralph A.; Buckner, Michael; Ayers, Kathleen; Li, Hua; Hu, Yanhui; Yang-Zhou, Donghui; Pan, Lei; Wang, Xiaoxi; Kelley, Colleen; Vinayagam, Arunachalam; Binari, Richard; Randklev, Sakara; Perkins, Lizabeth A.; Xie, Ting

2014-01-01

Stem cells possess the capacity to generate two cells of distinct fate upon division; one cell retaining stem cell identity and the other cell destined to differentiate. These cell fates are established by cell-type-specific genetic networks. To comprehensively identify components of these networks, we performed a large-scale RNAi screen in Drosophila female germline stem cells (GSCs) covering ~25% of the genome. The screen identified 366 genes that affect GSC maintenance, differentiation or ...

The Longitudinal STEM Identity Trajectories of Middle School Girls who Participated in a Single-Sex Informal STEM Education Program

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Hughes, Roxanne

2014-03-01

This study examined the longitudinal effects of participation in an all-girls STEM summer camp on young women's interest in STEM fields and motivation to pursue these fields. The SciGirls camp has been in existence since 2006, with its goal of providing a safe space for young women to explore STEM careers and strengthen their interest in these careers. Over 166 middle school age girls have participated in the program since it began in 2006. Of those participants, 60 responded to at least one of the follow up surveys that are sent every three years - 2009 and 2012. The surveys attempt to determine participants' level of interest in STEM. The survey was qualitative in nature and asked open ended questions. Results indicated that the camp had a positive effect on participants' perceptions of scientists and their work. This study adds to the literature that looks at the longitudinal impacts of informal STEM educational programs that expose young women to female scientist role models and mentors. This study supports the research that claims that exposing young women at an early age to science role models can positively alter their perception of science careers which can eventually increase the number of women who pursue these careers. This increase is important at a time when men still outnumber women in many science and engineering fields. This study was funded in part by the National Science Foundation Division of Materials Research through DMR 0654118.

Exploring self-defining memories in schizophrenia.

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Raffard, Stéphane; D'Argembeau, Arnaud; Lardi, Claudia; Bayard, Sophie; Boulenger, Jean-Philippe; Van Der Linden, Martial

2009-01-01

Previous studies have shown that patients with schizophrenia are impaired in recalling specific events from their personal past. However, the relationship between autobiographical memory impairments and disturbance of the sense of identity in schizophrenia has not been investigated in detail. In this study the authors investigated schizophrenic patients' ability to recall self-defining memories; that is, memories that play an important role in building and maintaining the self-concept. Results showed that patients recalled as many specific self-defining memories as healthy participants. However, patients with schizophrenia exhibited an abnormal reminiscence bump and reported different types of thematic content (i.e., they recalled less memories about past achievements and more memories regarding hospitalisation and stigmatisation of illness). Furthermore, the findings suggest that impairments in extracting meaning from personal memories could represent a core disturbance of autobiographical memory in patients with schizophrenia.

Processes and content of narrative identity development in adolescence: gender and well-being.

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McLean, Kate C; Breen, Andrea V

2009-05-01

The present study examined narrative identity in adolescence (14-18 years) in terms of narrative content and processes of identity development. Age- and gender-related differences in narrative patterns in turning point memories and gender differences in the content and functions for sharing those memories were examined, as was the relationship between narrative patterns and self-esteem. The narrative patterns focused on were meaning-making (learning from past events) and emotionality of the narratives, specified as overall positive emotional tone and redemptive sequencing. Results showed an age-related increase in meaning-making but no gender differences in the degree of meaning-making. Results further showed that gender predicted self-esteem and that boys evidenced higher self-esteem. Emotionality also predicted self-esteem; this was especially true for redemption and for boys. In terms of telling functions, girls endorsed more relational reasons for telling memories than did boys. Results are discussed in terms of potential gendered and nongendered pathways for identity development in adolescence. Copyright 2009 APA, all rights reserved

Ovary and fimbrial stem cells: biology, niche and cancer origins.

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Ng, Annie; Barker, Nick

2015-10-01

The mammalian ovary is covered by a single-layered epithelium that undergoes rupture and remodelling following each ovulation. Although resident stem cells are presumed to be crucial for this cyclic regeneration, their identity and mode of action have been elusive. Surrogate stemness assays and in vivo fate-mapping studies using recently discovered stem cell markers have identified stem cell pools in the ovary and fimbria that ensure epithelial homeostasis. Recent findings provide insights into intrinsic mechanisms and local extrinsic cues that govern the function of ovarian and fimbrial stem cells. These discoveries have advanced our understanding of stem cell biology in the ovary and fimbria, and lay the foundations for evaluating the contribution of resident stem cells to the initiation and progression of human epithelial ovarian cancer.

Little Scientists: Identity, Self-Efficacy, and Attitude Toward Science in a Girls' Science Camp

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Todd, Brandy

Underrepresentation of women and minorities in the science, technology, and engineering (STEM) fields is a perennial concern for researchers and policy-makers. Many causes of this problem have been identified. Less is known about what constitutes effective methods for increasing women's participation in STEM. This study examines the role that identity formation plays in encouraging girls to pursue STEM education and careers utilizing data from a cohort-based, informal science enrichment program that targets middle-school-aged girls. A Mixed-methods design was employed to examine girls' science interests, efficacy, attitudes, and identity---referred to as affinities. Quantitative data were collected before and after program participation using science affinity scales. Qualitative data included observations, focus groups, and individual interviews. This study builds on past research conducted on the same program. The study is presented in three components: fidelity of implementation, participant affinities, and science identity theory building. Quantitative and qualitative measures reveal that the program was implemented with high fidelity. Participants had high initial affinities for science as compared to a contrast group. Analysis of qualitative data of science affinities revealed several themes in girls' attitudes, experiences, and intentions toward science. Emergent themes discussed include girls' preferences and interests in science, gender and science efficacy, attitudes toward science, and elements of science identities. Archetypes of emergent science identities developed in this study (expert, experimenter, and inventor) inform different ways in which girls engage with and envision science study and careers. Implications for best practice in fostering science engagement and identities in middle-school-aged girls include the importance of hands-on science activities, the need for enthusiastic relatable role models, and an emphasis on deep understanding of

Memory and the Korsakoff syndrome: not remembering what is remembered.

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d'Ydewalle, Géry; Van Damme, Ilse

2007-03-14

Following the distinction between involuntary unconscious memory, involuntary conscious memory, and intentional retrieval, the focus of the present paper is whether there is an impairment of involuntary conscious memory among Korsakoff patients. At study, participants generated associations versus counted the number of letters with enclosed spaces or the number of vowels in the target words (semantic versus perceptual processing). In the Direct tests, stems were to be used to retrieve the targets with either guessing or no guessing allowed; in the Opposition tests, the stems were to be completed with the first word that came to mind but using another word if that first word was a target word; and in the Indirect tests, no reference was made to the target words from the study phase. In the Direct tests, the performance of Korsakoff patients was not necessarily worse than the one of healthy controls, provided guessing was allowed. More critical for the Korsakoff patients was the deficient involuntary conscious memory. The deficiency explained the suppression failures in the Opposition tests, the absence of performance differences between the Indirect and Opposition tests, the absence of a beneficial effect in providing information about the status of the stem, the performance boost when allowed to guess, and the very low rate of "Know"/"Remember" responses.

MicroRNAs: regulators of oncogenesis and stemness

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Papagiannakopoulos Thales

2008-06-01

Full Text Available Abstract MicroRNAs (miRNAs are essential post-transcriptional regulators that determine cell identity and fate. Aberrant expression of miRNAs can lead to diseases, including cancer. Expression of many miRNAs in the de-differentiated brain tumor cancer stem cells resembles that of neural stem cells. In this issue of BMC Medicine, Silber et al provide evidence of the expression of such miRNAs and their potential to mediate differentiation in both stem cell populations. In this commentary, we discuss the known functions of miRNAs in cancer and stem cells, their therapeutic potential and how the findings of Silber et al provide insight into the role of miR-124/miR-137 dysregulation in glioblastomas.

Listening to their voices: Exploring mathematics-science identity development of African American males in an urban school community

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Wilson, Kimi Leemar

National data continues to show an underrepresentation of African American males pursuing science, technology, engineering and mathematics (STEM) majors, careers and professions in the United States. Whites and Asian Americans are continuously positioned as the face of STEM education and participation. And while research has provided ways to support mathematics and science learning for African American males, there still remains a gap in understanding how their formed mathematics-science identities in K-12 public schooling influences STEM participation. The research undertaken in this study explores this gap, and uses an integrative identity framework to understand mathematics-science identity development which goes beyond personal identity, and explores the relational, collective and material components of identity. Specifically, this research seeks to answer the following research questions: What are the shared lived experiences that exist between a group of African American male students developing a mathematics-science identity, and how these shared lived experiences shape their mathematics-science identity development? Therefore, by analyzing African American males lived experiences employing an integrative identity framework fosters a greater understanding of how mathematics-science identity is formed in K-12 public schools, which impacts STEM education and participation. The high school aged youth featured in this study consist of four African American males, who live in a moderate size city in California. Data for this study consists of observations, phenomenological interviews, and policy document analysis that took place over six months. Data has been analyzed to describe and interpret the young men's mathematics and science experiences, as revealed in their K-12 public school education. This inquiry sought to make meaning of how African American males experience mathematics and science teaching and learning within K-12 public schooling and how these

The Relation Between Goals and Autobiographical Memory

DEFF Research Database (Denmark)

Johannessen, Kim Berg; Rasmussen, Anne Scharling; Berntsen, Dorthe

facilitate recall of goal congruent autobiographical memories which supports the idea of autobiographical memory facilitating goal attainment. Further, no differences between involuntary and voluntary memories with regard to frequency or characteristics of goal related content were found. Yet memories...... related to goals were rated as more central to the person's identity, life story and expectations for the future than non-goal related memories, irrespective of mode of recall. Interestingly, depression and PTSD symptoms correlated positively with the proportion of goal related memories, thereby......The present study examines involuntary (spontaneously retrieved) versus voluntary (deliberately retrieved) autobiographical memories in relation to earlier registered goals measured by the Personal Concern Inventory (Cox & Klinger, 2000). We found that the important and not yet planned goals...

A Qualitative Approach to the Intersection of Sexual, Ethnic, and Gender Identities.

Science.gov (United States)

Narvaez, Rafael F; Meyer, Ilan H; Kertzner, Robert M; Ouellette, Suzanne C; Gordon, Allegra R

In this paper we report on a new qualitative instrument designed to study the intersection of identities related to sexuality and race/ethnicity, and how people who hold those identities interact with social contexts. Researchers often resort to using separate measures to assess race/ethnicity, sexual orientation, and other target identities. But this approach can miss elements of a self-system that stem from the intersection of identities, the interactions between identities and social contexts, related shifts in identity over time, and related changes in the prominence and valence of identities. Using a small sub-sample, we demonstrate how our instrument can help researchers overcome these limitations. Our instrument was also designed for economy in administration and analysis, so that it could be used as a qualitative complement in large survey research.

Improved survival of acute lymphoblastic leukemia patients of HLA-A3/11 absent for donor KIR3DL2 after non-T-cell depleted HLA-identical sibling hematopoietic stem cells transplantation

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farhad shahsavar

2011-08-01

Conclusion: These data indicate that the absence of HLA class I ligand in the recipient for donor-inhibitory KIR can be a prognostic factor for transplantation outcomes in non-T-cell depleted HLA-identical sibling hematopoietic stem-cell transplantation and that the lack of HLA-A3/11 for donor KIR3DL2 can contribute to improved survival for patients with ALL.

An archetype of the collaborative efforts of psychotherapy and psychopharmacology in successfully treating dissociative identity disorder with comorbid bipolar disorder.

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Lakshmanan, Manu N; Meier, Stacey L Colton; Meier, Robert S; Lakshmanan, Ramaswamy

2010-07-01

We present a case where dissociative identity disorder was effectively treated with memory retrieval psychotherapy. However, the patient's comorbid bipolar disorder contributed to the patient's instability and fortified the amnesiac barriers that exist between alter personality states in dissociative identity disorder, which made memory retrieval difficult to achieve. Implications from this case indicate that a close collaboration between psychologist and psychiatrist focused on carefully diagnosing and treating existing comorbid conditions may be the most important aspect in treating dissociative identity disorder. We present our experience of successfully treating a patient with dissociative identity disorder and bipolar disorder using this collaborative method.

Spermatogonial stem cells: Progress and prospects

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Mitsuru Komeya

2015-01-01

Full Text Available Twenty years ago, the transplantation of spermatogonial stem cells (SSCs from a mouse to other recipient mice was shown to be feasible, which clearly demonstrated the functional identity of SSCs. Since then, several important new findings and other technical developments have followed, which included a new hypothesis on their cell kinetics and spermatogonial hierarchy in the testis, a culture method allowing their self-renewal and proliferation, a testis tissue organ culture method, which induced their complete differentiation up to sperm, and the in vitro induction of germ cells from embryonic stem cells and induced pluripotent stem cells. These advancements reinforced or advanced our understanding of this unique cell. Nonetheless, there are many unresolved questions in the study of spermatogonial stem cells and a long road remains until these cells can be used clinically in reproductive medicine.

The ethics of molecular memory modification.

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Hui, Katrina; Fisher, Carl E

2015-07-01

Novel molecular interventions have recently shown the potential to erase, enhance and alter specific long-term memories. Unique features of this form of memory modification call for a close examination of its possible applications. While there have been discussions of the ethics of memory modification in the literature, molecular memory modification (MMM) can provide special insights. Previously raised ethical concerns regarding memory enhancement, such as safety issues, the 'duty to remember', selfhood and personal identity, require re-evaluation in light of MMM. As a technology that exploits the brain's updating processes, MMM helps correct the common misconception that memory is a static entity by demonstrating how memory is plastic and subject to revision even in the absence of external manipulation. Furthermore, while putatively safer than other speculative technologies because of its high specificity, MMM raises notable safety issues, including potential insidious effects on the agent's emotions and personal identity. Nonetheless, MMM possesses characteristics of a more permissible form of modification, not only because it is theoretically safer, but because its unique mechanism of action requires a heightened level of cooperation from the agent. Discussions of memory modification must consider the specific mechanisms of action, which can alter the weight and relevance of various ethical concerns. MMM also highlights the need for conceptual accuracy regarding the term 'enhancement'; this umbrella term will have to be differentiated as new technologies are applied to a widening array of purposes. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

An Examination of the Processes of Student Science Identity Negotiation within an Informal Learning Community

Science.gov (United States)

Mark, Sheron L.

Scientific proficiency is important, not only for a solid, interdisciplinary educational foundation, but also for entry into and mobility within today's increasingly technological and globalized workplace, as well as for informed, democratic participation in society (National Academies Press, 2007b). Within the United States, low-income, ethnic minority students are disproportionately underperforming and underrepresented in science, as well as mathematics, engineering and other technology fields (Business-Higher Education Forum, 2011; National Assessment of Educational Progress, 2009). This is due, in part, to a lack of educational structures and strategies that can support low-income, ethnic minority students to become competent in science in equitable and empowering ways. In order to investigate such structures and strategies that may be beneficial for these students, a longitudinal, qualitative study was conducted. The 15 month study was an investigation of science identity negotiation informed by the theoretical perspectives of Brown's (2004) discursive science identities and Tan and Barton's (2008) identities-in-practice amongst ten high school students in an informal science program and employed an amalgam of research designs, including ethnography (Geertz, 1973), case study (Stake, 2000) and grounded theory (Glaser & Strauss, 1967). Findings indicated that the students made use of two strategies, discursive identity development and language use in science, in order to negotiate student science identities in satisfying ways within the limits of the TESJ practice. Additionally, 3 factors were identified as being supportive of successful student science identity negotiation in the informal practice, as well. These were (i) peer dynamics, (ii) significant social interactions, and (iii) student ownership in science. The students were also uncovered to be particularly open-minded to the field of STEM. Finally, with respect to STEM career development, specific

Curtailed T-cell activation curbs effector differentiation and generates CD8+ T cells with a naturally-occurring memory stem cell phenotype.

Science.gov (United States)

Zanon, Veronica; Pilipow, Karolina; Scamardella, Eloise; De Paoli, Federica; De Simone, Gabriele; Price, David A; Martinez Usatorre, Amaia; Romero, Pedro; Mavilio, Domenico; Roberto, Alessandra; Lugli, Enrico

2017-09-01

Human T memory stem (T SCM ) cells with superior persistence capacity and effector functions are emerging as important players in the maintenance of long-lived T-cell memory and are thus considered an attractive population to be used in adoptive transfer-based immunotherapy of cancer. However, the molecular signals regulating their generation remain poorly defined. Here we show that curtailed T-cell receptor stimulation curbs human effector CD8 + T-cell differentiation and allows the generation of CD45RO - CD45RA + CCR7 + CD27 + CD95 + -phenotype cells from highly purified naïve T-cell precursors, resembling naturally-occurring human T SCM . These cells proliferate extensively in vitro and in vivo, express low amounts of effector-associated genes and transcription factors and undergo considerable self-renewal in response to IL-15 while retaining effector differentiation potential. Such a phenotype is associated with a lower number of mitochondria compared to highly-activated effector T cells committed to terminal differentiation. These results shed light on the molecular signals that are required to generate long-lived memory T cells with potential application in adoptive cell transfer immunotherapy. © 2017 The Authors. European Journal of Immunology published by WILEY-VCH Verlag GmbH & Co.KGaA, Weinheim.

What-Where-When Memory and Encoding Strategies in Healthy Aging

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Cheke, Lucy G.

2016-01-01

Older adults exhibit disproportionate impairments in memory for item-associations. These impairments may stem from an inability to self-initiate deep encoding strategies. The present study investigates this using the "treasure-hunt task"; a what-where-when style episodic memory test that requires individuals to "hide" items…

Face identity recognition in autism spectrum disorders: a review of behavioral studies.

Science.gov (United States)

Weigelt, Sarah; Koldewyn, Kami; Kanwisher, Nancy

2012-03-01

Face recognition--the ability to recognize a person from their facial appearance--is essential for normal social interaction. Face recognition deficits have been implicated in the most common disorder of social interaction: autism. Here we ask: is face identity recognition in fact impaired in people with autism? Reviewing behavioral studies we find no strong evidence for a qualitative difference in how facial identity is processed between those with and without autism: markers of typical face identity recognition, such as the face inversion effect, seem to be present in people with autism. However, quantitatively--i.e., how well facial identity is remembered or discriminated--people with autism perform worse than typical individuals. This impairment is particularly clear in face memory and in face perception tasks in which a delay intervenes between sample and test, and less so in tasks with no memory demand. Although some evidence suggests that this deficit may be specific to faces, further evidence on this question is necessary. Copyright © 2011 Elsevier Ltd. All rights reserved.

Retinal stem cells and potential cell transplantation treatments

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Tai-Chi Lin

2014-11-01

Full Text Available The retina, histologically composed of ten delicate layers, is responsible for light perception and relaying electrochemical signals to the secondary neurons and visual cortex. Retinal disease is one of the leading clinical causes of severe vision loss, including age-related macular degeneration, Stargardt's disease, and retinitis pigmentosa. As a result of the discovery of various somatic stem cells, advances in exploring the identities of embryonic stem cells, and the development of induced pluripotent stem cells, cell transplantation treatment for retinal diseases is currently attracting much attention. The sources of stem cells for retinal regeneration include endogenous retinal stem cells (e.g., neuronal stem cells, Müller cells, and retinal stem cells from the ciliary marginal zone and exogenous stem cells (e.g., bone mesenchymal stem cells, adipose-derived stem cells, embryonic stem cells, and induced pluripotent stem cells. The success of cell transplantation treatment depends mainly on the cell source, the timing of cell harvesting, the protocol of cell induction/transplantation, and the microenvironment of the recipient's retina. This review summarizes the different sources of stem cells for regeneration treatment in retinal diseases and surveys the more recent achievements in animal studies and clinical trials. Future directions and challenges in stem cell transplantation are also discussed.

Cell-assembly coding in several memory processes.

Science.gov (United States)

Sakurai, Y

1998-01-01

The present paper discusses why the cell assembly, i.e., an ensemble population of neurons with flexible functional connections, is a tenable view of the basic code for information processes in the brain. The main properties indicating the reality of cell-assembly coding are neurons overlaps among different assemblies and connection dynamics within and among the assemblies. The former can be detected as multiple functions of individual neurons in processing different kinds of information. Individual neurons appear to be involved in multiple information processes. The latter can be detected as changes of functional synaptic connections in processing different kinds of information. Correlations of activity among some of the recorded neurons appear to change in multiple information processes. Recent experiments have compared several different memory processes (tasks) and detected these two main properties, indicating cell-assembly coding of memory in the working brain. The first experiment compared different types of processing of identical stimuli, i.e., working memory and reference memory of auditory stimuli. The second experiment compared identical processes of different types of stimuli, i.e., discriminations of simple auditory, simple visual, and configural auditory-visual stimuli. The third experiment compared identical processes of different types of stimuli with or without temporal processing of stimuli, i.e., discriminations of elemental auditory, configural auditory-visual, and sequential auditory-visual stimuli. Some possible features of the cell-assembly coding, especially "dual coding" by individual neurons and cell assemblies, are discussed for future experimental approaches. Copyright 1998 Academic Press.

The Threat of Sexism in a STEM Educational Setting: The Moderating Impacts of Ethnicity and Legitimacy Beliefs on Test Performance

Science.gov (United States)

O'Brien, Laurie T.; Garcia, Donna M.; Adams, Glenn; Villalobos, J. Guillermo; Hammer, Elliott; Gilbert, Patricia

2015-01-01

Social identity threat has negative consequences for women in science, technology, engineering, and mathematics (STEM) fields. The present study examined whether legitimacy beliefs--beliefs that status differences between men and women in STEM fields are fair--put women at risk for experiencing social identity threat and poorer performance on a…

Longing for home: displacement, memory and identity.

Science.gov (United States)

Ben-Yoseph, Miriam

2005-01-01

This article focuses on the relationship between the country of birth and the ability of the individual from that country to create a sense of home, identity and belonging in other countries and cultures. What is home? Is home the place where you were born and raised, where your parents live or where they are buried? Is home the place from where you were dislocated or where you live now? What does longing for home mean? The author draws on theory to address these questions but her personal story plays a prominent part.

Wilfred Own Re-Visited: A Psychoanalytic Reading of War, Memory, and Crisis of Identity in Wilfred Owen’s Poem Mental Cases

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Ali Güneş

2017-06-01

Full Text Available This paper focuses upon the psychoanalytic reading of Wilfred Owen’s poem Mental Cases. In so doing, first, the paper examines how the disturbing experiences and feelings of a tragic event such as a war, torture, rape or murder, which the surviving  victims, civilians and veteran soldiers store in the realm of their unconscious in the Freudian sense, start annoying their feelings after a while. That is, these memories of the past event continuously come later on in life under the troubling influence of recurring flashbacks of the traumatic events, nightmares, irritability, anxiety, and social withdrawal. Eventually these undesirable traumatic past experiences and memories repressed in the unconscious obviously causes individuals to have a kind of psychological disorder which powerfully affects their daily behaviour, life and identity. Secondly, the paper explores this relationship between conscious and unconscious aspect of life, along with the perception of identity, in Owen’s poem Mental Cases, in which the shell-shocked, war-torn veteran soldiers, who experienced and witnessed the shock of World War I and the death of their fellow soldiers, constantly remember the soldiers and innocent civilians who were brutally killed or whom they brutally killed in World War I. Now, these veteran soldiers call back those unhappy times, along with the death of soldiers and civilians, and then suffer in their psyche with a sense of guilt and disappointment: that is, recalling their shocking traumatic war experiences and their killing of many innocent people apparently cripple their vision of life and shatter their identities in the present. Through his representation of these veteran soldiers in such a way, Owen, as in his other poems, artistically and forcefully shows his own reaction, anger and dissatisfaction about the war and its distressing outcome in Mental Cases. Finally, the paper also examines how Owen’s critical view of war and its traumatic

Implications of neuroscience Psychoactive drugs and identity: between history and culture

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Lydia Feito Grande

2016-02-01

Full Text Available Neuroscientifical advances open the possibility to modify capacities in human beings, aimed to enhance them. An example is neurodrugs. Altering memory, attention or mood can make a difference in personal identity. This question about identity is analyzed and its implications on modification of human nature. This raises again the nature/culture debate, also from the contemporary neuroscience. The conclusion is that dynamism in human narrative identity is the result of an interaction between nature and culture.

Rhesus monkey neural stem cell transplantation promotes neural regeneration in rats with hippocampal lesions

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Li-juan Ye

2016-01-01

Full Text Available Rhesus monkey neural stem cells are capable of differentiating into neurons and glial cells. Therefore, neural stem cell transplantation can be used to promote functional recovery of the nervous system. Rhesus monkey neural stem cells (1 × 105 cells/μL were injected into bilateral hippocampi of rats with hippocampal lesions. Confocal laser scanning microscopy demonstrated that green fluorescent protein-labeled transplanted cells survived and grew well. Transplanted cells were detected at the lesion site, but also in the nerve fiber-rich region of the cerebral cortex and corpus callosum. Some transplanted cells differentiated into neurons and glial cells clustering along the ventricular wall, and integrated into the recipient brain. Behavioral tests revealed that spatial learning and memory ability improved, indicating that rhesus monkey neural stem cells noticeably improve spatial learning and memory abilities in rats with hippocampal lesions.

Accounting for immediate emotional memory enhancement

OpenAIRE

Talmi, Deborah; McGarry, Lucy M.

2012-01-01

Memory for emotional events is usually very good even when tested shortly after study, before it is altered by the influence of emotional arousal on consolidation. Immediate emotion-enhanced memory may stem from the influence of emotion on cognitive processes at encoding and retrieval. Our goal was to test which cognitive factors are necessary and sufficient to account for EEM, with a specific focus on clarifying the contribution of attention to this effect. In two experiments, participants e...

Effects of reducing attentional resources on implicit and explicit memory after severe traumatic brain injury.

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Watt, S; Shores, E A; Kinoshita, S

1999-07-01

Implicit and explicit memory were examined in individuals with severe traumatic brain injury (TBI) under conditions of full and divided attention. Participants included 12 individuals with severe TBI and 12 matched controls. In Experiment 1, participants carried out an implicit test of word-stem completion and an explicit test of cued recall. Results demonstrated that TBI participants exhibited impaired explicit memory but preserved implicit memory. In Experiment 2, a significant reduction in the explicit memory performance of both TBI and control participants, as well as a significant decrease in the implicit memory performance of TBI participants, was achieved by reducing attentional resources at encoding. These results indicated that performance on an implicit task of word-stem completion may require the availability of additional attentional resources that are not preserved after severe TBI.

Directed differentiation of basal forebrain cholinergic neurons from human pluripotent stem cells.

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Hu, Yao; Qu, Zhuang-Yin; Cao, Shi-Ying; Li, Qi; Ma, Lixiang; Krencik, Robert; Xu, Min; Liu, Yan

2016-06-15

Basal forebrain cholinergic neurons (BFCNs) play critical roles in learning, memory and cognition. Dysfunction or degeneration of BFCNs may connect to neuropathology, such as Alzheimer's disease, Down's syndrome and dementia. Generation of functional BFCNs may contribute to the studies of cell-based therapy and pathogenesis that is related to learning and memory deficits. Here we describe a detail method for robust generation of BFCNs from human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs). In this method, BFCN progenitors are patterned from hESC or hiPSC-derived primitive neuroepithelial cells, with the treatment of sonic hedgehog (SHH) or combination with its agonist Purmorphamine, and by co-culturing with human astrocytes. At day 20, ∼90% hPSC-derived progenitors expressed NKX2.1, which is a transcriptional marker for MGE. Moreover, around 40% of NKX2.1+ cells co-expressed OLIG2 and ∼15% of NKX2.1+ cells co-expressed ISLET1, which are ventral markers. At day 35, ∼40% neurons robustly express ChAT, most of which are co-labeled with NKX2.1, ISLET1 and FOXG1, indicating the basal forebrain-like identity. At day 45, these neurons express mature neuronal markers MAP2, Synapsin, and VAChT. In this method, undefined conditions including genetic modification or cell-sorting are avoided. As a choice, feeder free conditions are used to avoid ingredients of animal origin. Moreover, Purmorphamine can be substituted for SHH to induce ventral progenitors effectively and economically. We provide an efficient method to generate BFCNs from multiple hPSC lines, which offers the potential application for disease modeling and pharmacological studies. Copyright © 2016 Elsevier B.V. All rights reserved.

Science Identity's Influence on Community College Students' Engagement, Persistence, and Performance in Biology

Science.gov (United States)

Riccitelli, Melinda

In the United States (U.S.), student engagement, persistence, and academic performance levels in college science, technology, engineering, and mathematics (STEM) programs have been unsatisfactory over the last decade. Low student engagement, persistence, and academic performance in STEM disciplines have been identified as major obstacles to U.S. economic goals and U.S. science education objectives. The central and salient science identity a college student claims can influence his engagement, persistence, and academic achievement in college science. While science identity studies have been conducted on four-year college populations there is a gap in the literature concerning community college students' science identity and science performance. The purpose of this quantitative correlational study was to examine the relationship between community college students claimed science identities and engagement, persistence, and academic performance. A census sample of 264 community college students enrolled in biology during the summer of 2015 was used to study this relationship. Science identity and engagement levels were calculated using the Science Identity Centrality Scale and the Biology Motivation Questionnaire II, respectively. Persistence and final grade data were collected from institutional and instructor records. Engagement significantly correlated to, r =.534, p = .01, and varied by science identity, p < .001. Percent final grade also varied by science identity (p < .005), but this relationship was weaker (r = .208, p = .01). Results for science identity and engagement and final grade were consistent with the identity literature. Persistence did not vary by science identity in this student sample (chi2 =2.815, p = .421). This result was inconsistent with the literature on science identity and persistence. Quantitative results from this study present a mixed picture of science identity status at the community college level. It is suggested, based on the findings

How Theaters Remember: Cultures of Memory in Institutionalized Systems

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Milena Dragićević Šešić

2014-11-01

Full Text Available The aim of this study is to explore organizational policies and strategies regarding the institutional memory of Belgrade’s repertoire theaters. The concept of institutional (organizational memory has not been developed within the culture of memory theory. The role of theater in the culture of memory has been researched mostly through studies of its repertoire, corresponding to how theaters deal with issues of glory, guilt, or shame. This study explores how theaters rethink their own past and organizational culture, how they use their capacity for re-imagining themselves, for clarifying their role and function in different historical moments. The objective of this research is to identify the main institutional policies and types of strategies used for preserving institutional memory through key narratives of remembering, and key methods of inter-generational transfer. The sample comprises of four Belgrade-based public repertoire theaters: the Yugoslav Dramatic Theater (JDP, the Belgrade Dramatic Theater (BDP, Atelje 212, and Bitef Theater. Specific attention is given to the means of transmission, of individual (episodic memories into the collective consciousness, influencing organizational cultures and shaping a theater’s identity (semantic memory. Research has shown that there are important differences in active policies of preserving institutional memory among Belgrade’s theaters. Different organizational and programming strategies were implemented in order to safeguard institutional identity and memory, particularly in theaters with a permanent ensemble. The major difference is between theaters whose culture of memory might be called “non-existent” (Bitef, or “in storage” (BDP, and those succeeding in creating a functional memory (JDP, Atelje 212.

Identity politics: Exploring Georgian foreign policy behavior

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Kornely Kakachia

2015-07-01

Full Text Available This paper analyses the extent to which Georgia's pro-Western foreign policy orientation stems from ideas and identity rather than from materialist and systemic factors alone. Finding such narrow approaches insufficient for explaining small state behavior, and drawing on liberal and constructivist approaches to international relations theory, the article argues that Georgia's foreign policy orientation has a strong basis in the widespread ideological perception amongst the local political elite that Georgia “belongs” in the West. Based on this theoretical framework, this paper provides a historical overview of Georgia's foreign policy, tracing the evolution of Georgia's identity from seeing itself as “Christian” in contrast to its Islamic neighbors, to identifying as European in contrast to a modern, Russian “other”. As Georgia attempts to construct a collective international identity, the devotion to the idea of Euro-Atlantic integration as a “sacred destiny” amongst the country's elite has significant foreign policy implications. This article overviews the current challenges and dilemmas of self-identification and investigates the roles that national identity and the prevailing “European” identity play in Georgia's quest for “desovietization”.

A matter of identity — Phenotype and differentiation potential of human somatic stem cells

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S.E.P. New

2015-07-01

Full Text Available Human somatic stem cells with neural differentiation potential can be valuable for developing cell-based therapies, including treatment of birth-related defects, while avoiding issues associated with cell reprogramming. Precisely defining the “identity” and differentiation potential of somatic stem cells from different sources, has proven difficult, given differences in sets of specific markers, protocols used and lack of side-by-side characterization of these cells in different studies. Therefore, we set to compare expression of mesenchymal and neural markers in human umbilical cord-derived mesenchymal stem cells (UC-MSCs, pediatric adipose-derived stem cells (p-ADSCs in parallel with human neural stem cells (NSCs. We show that UC-MSCs at a basal level express mesenchymal and so-called “neural” markers, similar to that we previously reported for the p-ADSCs. All somatic stem cell populations studied, independently from tissue and patient of origin, displayed a remarkably similar expression of surface markers, with the main difference being the restricted expression of CD133 and CD34 to NSCs. Expression of certain surface and neural markers was affected by the expansion medium used. As predicted, UC-MSCs and p-ADSCs demonstrated tri-mesenchymal lineage differentiation potential, though p-ADSCs display superior chondrogenic differentiation capability. UC-MSCs and p-ADSCs responded also to neurogenic induction by up-regulating neuronal markers, but crucially they appeared morphologically immature when compared with differentiated NSCs. This highlights the need for further investigation into the use of these cells for neural therapies. Crucially, this study demonstrates the lack of simple means to distinguish between different cell types and the effect of culture conditions on their phenotype, and indicates that a more extensive set of markers should be used for somatic stem cell characterization, especially when developing therapeutic

Schizophrenia patients demonstrate a dissociation on declarative and non-declarative memory tests.

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Perry, W; Light, G A; Davis, H; Braff, D L

2000-12-15

Declarative memory refers to the recall and recognition of factual information. In contrast, non-declarative memory entails a facilitation of memory based on prior exposure and is typically assessed with priming and perceptual-motor sequencing tasks. In this study, schizophrenia patients were compared to normal comparison subjects on two computerized memory tasks: the Word-stem Priming Test (n=30) and the Pattern Sequence Learning Test (n=20). Word-stem Priming includes recall, recognition (declarative) and priming (non-declarative) components of memory. The schizophrenia patients demonstrated an impaired performance on recall of words with relative improvement during the recognition portion of the test. Furthermore, they performed normally on the priming portion of the test. Thus, on tests of declarative memory, the patients had retrieval deficits with intact performance on the non-declarative memory component. The Pattern Sequence Learning Test utilizes a serial reaction time paradigm to assess non-declarative memory. The schizophrenia patients' serial reaction time was significantly slower than that of comparison subjects. However, the patients' rate of acquisition was not different from the normal comparison group. The data suggest that patients with schizophrenia process more slowly than normal, but have an intact non-declarative memory. The schizophrenia patients' dissociation on declarative vs. non-declarative memory tests is discussed in terms of possible underlying structural impairment.

Epigenetic Memory Underlies Cell-Autonomous Heterogeneous Behavior of Hematopoietic Stem Cells.

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Yu, Vionnie W C; Yusuf, Rushdia Z; Oki, Toshihiko; Wu, Juwell; Saez, Borja; Wang, Xin; Cook, Colleen; Baryawno, Ninib; Ziller, Michael J; Lee, Eunjung; Gu, Hongcang; Meissner, Alexander; Lin, Charles P; Kharchenko, Peter V; Scadden, David T

2016-11-17

Stem cells determine homeostasis and repair of many tissues and are increasingly recognized as functionally heterogeneous. To define the extent of-and molecular basis for-heterogeneity, we overlaid functional, transcriptional, and epigenetic attributes of hematopoietic stem cells (HSCs) at a clonal level using endogenous fluorescent tagging. Endogenous HSC had clone-specific functional attributes over time in vivo. The intra-clonal behaviors were highly stereotypic, conserved under the stress of transplantation, inflammation, and genotoxic injury, and associated with distinctive transcriptional, DNA methylation, and chromatin accessibility patterns. Further, HSC function corresponded to epigenetic configuration but not always to transcriptional state. Therefore, hematopoiesis under homeostatic and stress conditions represents the integrated action of highly heterogeneous clones of HSC with epigenetically scripted behaviors. This high degree of epigenetically driven cell autonomy among HSCs implies that refinement of the concepts of stem cell plasticity and of the stem cell niche is warranted. Copyright © 2016 Elsevier Inc. All rights reserved.

The B-MYB transcriptional network guides cell cycle progression and fate decisions to sustain self-renewal and the identity of pluripotent stem cells.

Science.gov (United States)

Zhan, Ming; Riordon, Daniel R; Yan, Bin; Tarasova, Yelena S; Bruweleit, Sarah; Tarasov, Kirill V; Li, Ronald A; Wersto, Robert P; Boheler, Kenneth R

2012-01-01

Embryonic stem cells (ESCs) are pluripotent and have unlimited self-renewal capacity. Although pluripotency and differentiation have been examined extensively, the mechanisms responsible for self-renewal are poorly understood and are believed to involve an unusual cell cycle, epigenetic regulators and pluripotency-promoting transcription factors. Here we show that B-MYB, a cell cycle regulated phosphoprotein and transcription factor critical to the formation of inner cell mass, is central to the transcriptional and co-regulatory networks that sustain normal cell cycle progression and self-renewal properties of ESCs. Phenotypically, B-MYB is robustly expressed in ESCs and induced pluripotent stem cells (iPSCs), and it is present predominantly in a hypo-phosphorylated state. Knockdown of B-MYB results in functional cell cycle abnormalities that involve S, G2 and M phases, and reduced expression of critical cell cycle regulators like ccnb1 and plk1. By conducting gene expression profiling on control and B-MYB deficient cells, ChIP-chip experiments, and integrative computational analyses, we unraveled a highly complex B-MYB-mediated transcriptional network that guides ESC self-renewal. The network encompasses critical regulators of all cell cycle phases and epigenetic regulators, pluripotency transcription factors, and differentiation determinants. B-MYB along with E2F1 and c-MYC preferentially co-regulate cell cycle target genes. B-MYB also co-targets genes regulated by OCT4, SOX2 and NANOG that are significantly associated with stem cell differentiation, embryonic development, and epigenetic control. Moreover, loss of B-MYB leads to a breakdown of the transcriptional hierarchy present in ESCs. These results coupled with functional studies demonstrate that B-MYB not only controls and accelerates cell cycle progression in ESCs it contributes to fate decisions and maintenance of pluripotent stem cell identity.

Autonoesis and dissociative identity disorder.

Science.gov (United States)

Morton, John

2018-01-01

Dissociative identity disorder is characterised by the presence in one individual of two or more alternative personality states (alters). For such individuals, the memory representation of a particular event can have full episodic, autonoetic status for one alter, while having the status of knowledge or even being inaccessible to a second alter. This phenomenon appears to create difficulties for a purely representational theory and is presented to Mahr & Csibra (M&C) for their consideration.

Auditory short-term memory behaves like visual short-term memory.

Directory of Open Access Journals (Sweden)

Kristina M Visscher

2007-03-01

Full Text Available Are the information processing steps that support short-term sensory memory common to all the senses? Systematic, psychophysical comparison requires identical experimental paradigms and comparable stimuli, which can be challenging to obtain across modalities. Participants performed a recognition memory task with auditory and visual stimuli that were comparable in complexity and in their neural representations at early stages of cortical processing. The visual stimuli were static and moving Gaussian-windowed, oriented, sinusoidal gratings (Gabor patches; the auditory stimuli were broadband sounds whose frequency content varied sinusoidally over time (moving ripples. Parallel effects on recognition memory were seen for number of items to be remembered, retention interval, and serial position. Further, regardless of modality, predicting an item's recognizability requires taking account of (1 the probe's similarity to the remembered list items (summed similarity, and (2 the similarity between the items in memory (inter-item homogeneity. A model incorporating both these factors gives a good fit to recognition memory data for auditory as well as visual stimuli. In addition, we present the first demonstration of the orthogonality of summed similarity and inter-item homogeneity effects. These data imply that auditory and visual representations undergo very similar transformations while they are encoded and retrieved from memory.

Auditory short-term memory behaves like visual short-term memory.

Science.gov (United States)

Visscher, Kristina M; Kaplan, Elina; Kahana, Michael J; Sekuler, Robert

2007-03-01

Are the information processing steps that support short-term sensory memory common to all the senses? Systematic, psychophysical comparison requires identical experimental paradigms and comparable stimuli, which can be challenging to obtain across modalities. Participants performed a recognition memory task with auditory and visual stimuli that were comparable in complexity and in their neural representations at early stages of cortical processing. The visual stimuli were static and moving Gaussian-windowed, oriented, sinusoidal gratings (Gabor patches); the auditory stimuli were broadband sounds whose frequency content varied sinusoidally over time (moving ripples). Parallel effects on recognition memory were seen for number of items to be remembered, retention interval, and serial position. Further, regardless of modality, predicting an item's recognizability requires taking account of (1) the probe's similarity to the remembered list items (summed similarity), and (2) the similarity between the items in memory (inter-item homogeneity). A model incorporating both these factors gives a good fit to recognition memory data for auditory as well as visual stimuli. In addition, we present the first demonstration of the orthogonality of summed similarity and inter-item homogeneity effects. These data imply that auditory and visual representations undergo very similar transformations while they are encoded and retrieved from memory.

Tracking moving identities: after attending the right location, the identity does not come for free.

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Yaïr Pinto

Full Text Available Although tracking identical moving objects has been studied since the 1980's, only recently the study into tracking moving objects with distinct identities has started (referred to as Multiple Identity Tracking, MIT. So far, only behavioral studies into MIT have been undertaken. These studies have left a fundamental question regarding MIT unanswered, is MIT a one-stage or a two-stage process? According to the one-stage model, after a location has been attended, the identity is released without effort. However, according to the two-stage model, there are two effortful stages in MIT, attending to a location, and attending to the identity of the object at that location. In the current study we investigated this question by measuring brain activity in response to tracking familiar and unfamiliar targets. Familiarity is known to automate effortful processes, so if attention to identify the object is needed, this should become easier. However, if no such attention is needed, familiarity can only affect other processes (such as memory for the target set. Our results revealed that on unfamiliar trials neural activity was higher in both attentional networks, and visual identification networks. These results suggest that familiarity in MIT automates attentional identification processes, thus suggesting that attentional identification is needed in MIT. This then would imply that MIT is essentially a two-stage process, since after attending the location, the identity does not seem to come for free.

'I remember therefore I am, and I am therefore I remember': exploring the contributions of episodic and semantic self-knowledge to strength of identity.

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Haslam, Catherine; Jetten, Jolanda; Haslam, S Alexander; Pugliese, Cara; Tonks, James

2011-05-01

The present research explores the relationship between the two components of autobiographical memory--episodic and semantic self-knowledge--and identity strength in older adults living in the community and residential care. Participants (N= 32) completed the autobiographical memory interview and measures of personal identity strength and multiple group memberships. Contrary to previous research, autobiographical memory for all time periods (childhood, early adulthood, and recent life) in the semantic domain was associated with greater strength in personal identity. Further, we obtained support for the hypothesis that the relationship between episodic self-knowledge and identity strength would be mediated by knowledge of personal semantic facts. However, there was also support for a reverse mediation model indicating that a strong sense of identity is associated with semantic self-knowledge and through this may enhance self-relevant recollection. The discussion elaborates on these findings and we propose a self-knowledge and identity model (SKIM) whereby semantic self-knowledge mediates a bidirectional relationship between episodic self-knowledge and identity. ©2010 The British Psychological Society.

InsightSTEM Campus Ambassadors: Welcoming, Including, and Supporting All in STEM Careers Worldwide

Science.gov (United States)

Noel-Storr, J.

2016-12-01

Definitions of genders and, races, ethnicities, abilities and sexualities tend to exist on a binary scale (e.g. male/female, black/white) both for inclusiveness and evaluation of programs. This has the potential to be a schism for individuals who are choosing to enter STEM fields when if their self-identity does not fit this these predefined multi-polar templates. At InsightSTEM, in our Campus Ambassadors program (which has over 290 grassroots members in over 25 countries) we have been striving to nullify this effect... For example, on our application, we choose to not ask for any demographic data, in any spectrum, because those data make no sense on a global stage. We question that if race, gender, sexuality and ethnicity are all on a spectrum: is any program devoted to a particular group appropriate? Instead we deliver professional development to students worldwide to train them to become aware and inclusive STEM educators, involving everyone in their programs no matter what their background. We will present the ways we work with our Campus Ambassadors to create programs that, rather than focusing on particular groups, are truly inclusive, in developing their skills and empowering them to create inclusive programs worldwide for all. InsightSTEM Campus Ambassadors: Welcoming, Including, and & Supporting All in STEM Careers Worldwide

Heterogeneity and plasticity of epidermal stem cells

DEFF Research Database (Denmark)

Schepeler, Troels; Page, Mahalia E; Jensen, Kim Bak

2014-01-01

The epidermis is an integral part of our largest organ, the skin, and protects us against the hostile environment. It is a highly dynamic tissue that, during normal steady-state conditions, undergoes constant turnover. Multiple stem cell populations residing in autonomously maintained compartments...... facilitate this task. In this Review, we discuss stem cell behaviour during normal tissue homeostasis, regeneration and disease within the pilosebaceous unit, an integral structure of the epidermis that is responsible for hair growth and lubrication of the epithelium. We provide an up-to-date view...... of the pilosebaceous unit, encompassing the heterogeneity and plasticity of multiple discrete stem cell populations that are strongly influenced by external cues to maintain their identity and function....

Standard object recognition memory and "what" and "where" components: Improvement by post-training epinephrine in highly habituated rats.

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Jurado-Berbel, Patricia; Costa-Miserachs, David; Torras-Garcia, Meritxell; Coll-Andreu, Margalida; Portell-Cortés, Isabel

2010-02-11

The present work examined whether post-training systemic epinephrine (EPI) is able to modulate short-term (3h) and long-term (24 h and 48 h) memory of standard object recognition, as well as long-term (24 h) memory of separate "what" (object identity) and "where" (object location) components of object recognition. Although object recognition training is associated to low arousal levels, all the animals received habituation to the training box in order to further reduce emotional arousal. Post-training EPI improved long-term (24 h and 48 h), but not short-term (3 h), memory in the standard object recognition task, as well as 24 h memory for both object identity and object location. These data indicate that post-training epinephrine: (1) facilitates long-term memory for standard object recognition; (2) exerts separate facilitatory effects on "what" (object identity) and "where" (object location) components of object recognition; and (3) is capable of improving memory for a low arousing task even in highly habituated rats.

On the mirror of the memory: Macau a mythical place of reconstruction of identity in the works of Maria Ondina Braga

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Dora Maria Nunes Gago

2016-01-01

Full Text Available Born in Braga in January 1932, where she also died (March 2003, the Portuguese writer and translator Maria Ondina Braga travelled to several countries, lived in England, France, India (Goa, Angola, Macau and China. Those existential journeys to different corners of the world are fictionalized into her narratives, as in Estátua de Sal (Braga, 1965b and A Passagem do Cabo (Braga, 1994 – which will be analyzed in this work. By drawing on imagology we shall discuss the mechanisms used by the narrator in the process of identity reconstruction, through the memory in the midst of alterity and the exotic ‘Other’, having Macao as a scenario.

Raising European Citizens: Constructing European Identities in French and English Textbooks

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Inari Sakki

2016-06-01

Full Text Available Schools play a pivotal role in the formation of identities and in the political socialization of youth. This study explores the social representations of European integration in French and English school textbooks and shows how the social representations are discursively used to construct national and European identities. By analysing the history and civics textbooks of major educational publishers, this study aims to demonstrate how European integration is understood, made familiar and concretized in the school textbooks of the two influential but different European countries. The findings suggest some shared and some diverse patterns in the way the two European countries portray and construct the political project of European integration. These representations, constructed around French Europe in French textbooks and ambivalent Europe in English textbooks, share the images of a strong European economy and a French-led political Europe. However, they position themselves differently with respect to the United States, motivation for the European unification process and the significance of common values and heritage. In both countries textbooks draw upon memories that are important for group identity. While the French textbooks make European integration meaningful in reference to a shared post-war collective memory and to a cultural memory based on a more ancient idea of Europe, shared values and heritage, the English textbooks anchor it more strongly to domestic policy.

Music in advertising and consumer identity: The search for Heideggerian authenticity

OpenAIRE

Abolhasani, Morteza; Oakes, Steve; Oakes, Helen

2017-01-01

This study discusses netnographic findings involving 472 YouTube postings categorized to identify themes regarding consumers’ experience of music in advertisements. Key themes relate to musical taste, musical indexicality, musical repetition and musical authenticity. Postings reveal how music conveys individual taste and is linked to personal memories and Heidegger’s coincidental time where moments of authenticity may be triggered in a melee of emotions, memories and projections. Identity pro...

[Neuroscience and collective memory: memory schemas linking brain, societies and cultures].

Science.gov (United States)

Legrand, Nicolas; Gagnepain, Pierre; Peschanski, Denis; Eustache, Francis

2015-01-01

During the last two decades, the effect of intersubjective relationships on cognition has been an emerging topic in cognitive neurosciences leading through a so-called "social turn" to the formation of new domains integrating society and cultures to this research area. Such inquiry has been recently extended to collective memory studies. Collective memory refers to shared representations that are constitutive of the identity of a group and distributed among all its members connected by a common history. After briefly describing those evolutions in the study of human brain and behaviors, we review recent researches that have brought together cognitive psychology, neuroscience and social sciences into collective memory studies. Using the reemerging concept of memory schema, we propose a theoretical framework allowing to account for collective memories formation with a specific focus on the encoding process of historical events. We suggest that (1) if the concept of schema has been mainly used to describe rather passive framework of knowledge, such structure may also be implied in more active fashions in the understanding of significant collective events. And, (2) if some schema researches have restricted themselves to the individual level of inquiry, we describe a strong coherence between memory and cultural frameworks. Integrating the neural basis and properties of memory schema to collective memory studies may pave the way toward a better understanding of the reciprocal interaction between individual memories and cultural resources such as media or education. © Société de Biologie, 2016.

An Archetype of the Collaborative Efforts of Psychotherapy and Psychopharmacology in Successfully Treating Dissociative Identity Disorder with Comorbid Bipolar Disorder

OpenAIRE

Lakshmanan, Manu N.; Meier, Stacey L. Colton; Meier, Robert S.; Lakshmanan, Ramaswamy

2010-01-01

We present a case where dissociative identity disorder was effectively treated with memory retrieval psychotherapy. However, the patient’s comorbid bipolar disorder contributed to the patient’s instability and fortified the amnesiac barriers that exist between alter personality states in dissociative identity disorder, which made memory retrieval difficult to achieve. Implications from this case indicate that a close collaboration between psychologist and psychiatrist focused on carefully dia...

Integrated cross-domain object storage in working memory: evidence from a verbal-spatial memory task.

Science.gov (United States)

Morey, Candice C

2009-11-01

Working-memory theories often include domain-specific verbal and visual stores (e.g., the phonological and visuospatial buffers of Baddeley, 1986), and some also posit more general stores thought to be capable of holding verbal or visuospatial materials (Baddeley, 2000; Cowan, 2005). However, it is currently unclear which type of store is primarily responsible for maintaining objects that include components from multiple domains. In these studies, a spatial array of letters was followed by a single probe identical to an item in the array or differing systematically in spatial location, letter identity, or their combination. Concurrent verbal rehearsal suppression impaired memory in each of these trial types in a task that required participants to remember verbal-spatial binding, but did not impair memory for spatial locations if the task did not require verbal-spatial binding for a correct response. Thus, spatial information might be stored differently when it must be bound to verbal information. This suggests that a cross-domain store such as the episodic buffer of Baddeley (2000) or the focus of attention of Cowan (2001) might be used for integrated object storage, rather than the maintenance of associations between features stored in separate domain-specific buffers.

Post-encoding emotional arousal enhances consolidation of item memory, but not reality-monitoring source memory.

Science.gov (United States)

Wang, Bo; Sun, Bukuan

2017-03-01

The current study examined whether the effect of post-encoding emotional arousal on item memory extends to reality-monitoring source memory and, if so, whether the effect depends on emotionality of learning stimuli and testing format. In Experiment 1, participants encoded neutral words and imagined or viewed their corresponding object pictures. Then they watched a neutral, positive, or negative video. The 24-hour delayed test showed that emotional arousal had little effect on both item memory and reality-monitoring source memory. Experiment 2 was similar except that participants encoded neutral, positive, and negative words and imagined or viewed their corresponding object pictures. The results showed that positive and negative emotional arousal induced after encoding enhanced consolidation of item memory, but not reality-monitoring source memory, regardless of emotionality of learning stimuli. Experiment 3, identical to Experiment 2 except that participants were tested only on source memory for all the encoded items, still showed that post-encoding emotional arousal had little effect on consolidation of reality-monitoring source memory. Taken together, regardless of emotionality of learning stimuli and regardless of testing format of source memory (conjunction test vs. independent test), the facilitatory effect of post-encoding emotional arousal on item memory does not generalize to reality-monitoring source memory.

Young Tamil Hindus in Denmark and Their Relationship to Tradition and Collective Memory

DEFF Research Database (Denmark)

Fibiger, Marianne Qvortrup

2011-01-01

This article deals with young, well-educated Tamil Hindus in Denmark, and how they balance between being part of a shared Tamil cultural heritage or cultural memory and at the same time being part of Danish society. It will try to illuminate the situations and contexts in which cultural heritage...... is a resource or hindrance in this negotiation. It will also try to clarify how young Tamil Hindus’ relation to cultural memory seems to differ in comparison with their parents’. One of the main differences is young Tamil Hindus’ very open-minded differentiation between being a Hindu (religious identity), being...... a Tamil (cultural identity) and being a Dane with a Tamil background (social identity). This article builds on empirical research on Sri Lankan Tamil Hindus in Denmark, including around 50 interviews with young Tamil Hindus, complemented by the theory of collective memory....

Autobiographical Memory in Borderline Personality Disorder – A Review

DEFF Research Database (Denmark)

Beck, Morten; Elklit, Ask; Simonsen, Erik

2015-01-01

Borderline personality disorder is a severe psychiatric illness. A key feature of the disorder is a disorganized sense of self often referred to as identity diffusion. Autobiographical memory is memory for personal life events. One of the main functions of these memories is to enable us...... to understand who we are by connecting past, present and future experiences. It seems that autobiographical memory is in some way disrupted in individuals with borderline personality disorder. A systematic review is conducted looking at studies that focus on the potential connections. We find that although......, autobiographical memory and borderline personality disorder....

African American women making race work in science, technology, engineering, and math (STEM)

Science.gov (United States)

Galloway, Stephanie Nicole

African American women maintain distinctive social locations at the intersection of race, gender, and class (Crenshaw, 1991; Collins, 1986; 2000; Wing, 2003). However, their voices, interpretation of experiences, and concern with the use of formal education as a mechanism for racial uplift have not been priorities in feminist movements (hooks, 1981; 1989; Perkins, 1993; Smith, 1998; Spitzack & Carter, 1987). Alternatively, Black feminist thought (Collins, 1990; 2000) is a theory constructed by and for African American women. Given the consequences of pursuing formal education in the histories of African American women and the paucity of African American women represented in STEM fields, the purpose of this study was to (a) reveal how African American women conducting research in STEM disciplines accomplished their professional goals, (b) learn how the women negotiated their multiple identities (i.e. race, gender, and class), (c) link the history of educational experiences among African Americans with agendas for social justice, (d) understand how African American women in STEM align their personal accomplishments with broader agendas for activism in higher education, and (e) discover whether there is a collective identity that successful African American women in STEM share. Using Black feminist thought (Collins, 1986; 2000) and narrative analysis of semi- interviews with eight African American women in STEM, the findings from this study revealed: (a) the women in this study described the challenges of pursuing a career in STEM from a feminist perspective, identifying gender as more significant than race; (b) the women in this study experienced more positive interactions with Black male, White female, and White male mentors than with Black female mentors; (c) the women in this study described the use of empowering strategies for overcoming obstacles in their academic pathways; and (d) their collective academic identities were formed by early interactions with

Women in STEM: The Effect of Undergraduate Research on Persistence

Science.gov (United States)

Wilker, Jodi

The underrepresentation of women in science, technology, engineering, and math (STEM) careers constitutes a major issue in postsecondary science education. Perseverance of women in STEM is linked to a strong science identity. Experiential learning activities, such as undergraduate research, increase science identity and thus should help keep women in STEM. Most studies on research program development are from 4-year institutions, yet many women start at community colleges. The goal of this study was to fill this gap. Science identity and experiential learning theories provided the framework for this case study at a local institution (LECC). Semistructured interviews determined college science faculty and administrators perceptions of advantages and disadvantages of undergraduate research, the viability of developing a research program, and specific research options feasible for LECC. Transcripted data were analyzed through multiple rounds of coding yielding five themes: faculty perception of undergraduate research, authentic experiences, health technologies/nursing programs, LECC students career focus, and the unique culture at LECC. The most viable type of undergraduate research for LECC is course-based and of short timeframe. The project study advocates the use of citizen science (CS) studies in the classroom as they are relatively short-term and can take the place of lab sessions. The true benefit is that students perform authentic science by contributing to an actual scientific research project. CS projects can effect social change by developing science literate citizens, empowering faculty to create authentic learning experiences, and by sparking interest in science and directing women into STEM careers.

The Development of Explicit Memory for Basic Perceptual Features.

Science.gov (United States)

Gulya, Michelle; Rossi-George, Alba; Hartshorn, Kristen; Vieira, Aurora; Rovee-Collier, Carolyn; Johnson, Marcia K.; Chalfonte, Barbara L.

2002-01-01

Three experiments with 164 individuals between 4 and 80 years old examined age-related changes in explicit memory for three perceptual features: item identity, color, and location. Findings indicated that performance on explicit memory tests was not a consistent inverted U-shaped function of age across various features, but depended on the…

Cortisol response mediates the effect of post-reactivation stress exposure on contextualization of emotional memories.

Science.gov (United States)

Bos, Marieke G N; Jacobs van Goethem, Tessa H; Beckers, Tom; Kindt, Merel

2014-12-01

Retrieval of traumatic experiences is often accompanied by strong feelings of distress. Here, we examined in healthy participants whether post-reactivation stress experience affects the context-dependency of emotional memory. First, participants studied words from two distinctive emotional categories (i.e., war and disease) presented against a category-related background picture. One day later, participants returned to the lab and received a reminder of the words of one emotional category followed by exposure to a stress task (Stress group, n=22) or a control task (Control group, n=24). Six days later, memory contextualization was tested using a word stem completion task. Half of the word stems were presented against the encoding context (i.e., congruent context) and the other half of the word stems were presented against the other context (i.e., incongruent context). The results showed that participants recalled more words in the congruent context than in the incongruent context. Interestingly, cortisol mediated the effect of stress exposure on memory contextualization. The stronger the post-reactivation cortisol response, the more memory performance relied on the contextual embedding of the words. Taken together, the current findings suggest that a moderate cortisol response after memory reactivation might serve an adaptive function in preventing generalization of emotional memories over contexts. Copyright © 2014 Elsevier Ltd. All rights reserved.

Cyborg Cinema: (Dis)Embodying Cultural Memory in the Digital Age

OpenAIRE

Parfitt, Clare

2009-01-01

In postmodernity, a range of digital technologies are used to store memories. These include digital cameras, ipods, memory sticks, and online repositories such as YouTube and Flickr. This process is not just personal. Mediated memories, such as songs stored on ipods and films stored on YouTube, often refer to collective experiences, whether those of a group of friends, or a global audience. Once stored, these memory files have the capacity to reinforce existing group identities, as well as cr...

Silencios. Visual memory of the Holocaust in Colombia

Directory of Open Access Journals (Sweden)

Lorena Cardona González

2017-01-01

complexity to produce an image in a context of pain; the second, taking into account the work of Michael Pollak, focuses on how memory becomes an essential component of identity, and although this is traumatic, their times, enunciations and hearings suffer postponements, suppression and concealments. These components enable a regard toward the memory of the Holocaust in Colombia

Autobiographical memory decline in Alzheimer's disease, a theoretical and clinical overview.

Science.gov (United States)

El Haj, Mohamad; Antoine, Pascal; Nandrino, Jean Louis; Kapogiannis, Dimitrios

2015-09-01

Autobiographical memory, or memory for personal experiences, allows individuals to define themselves and construct a meaningful life story. Decline of this ability, as observed in Alzheimer's disease (AD), results in an impaired sense of self and identity. In our model (AMAD: Autobiographical Memory in Alzheimer's Disease), we present a critical review of theories and findings regarding cognitive and neuroanatomical underpinnings of autobiographical memory and its decline in AD and highlight studies on its clinical rehabilitation. We propose that autobiographical recall in AD is mainly characterized by loss of associated episodic information, which leads to de-contextualization of autobiographical memories and a shift from reliving past events to a general sense of familiarity. This decline refers to retrograde, but also anterograde amnesia that affects newly acquired memories besides remote ones. One consequence of autobiographical memory decline in AD is decreased access to memories that shape self-consciousness, self-knowledge, and self-images, leading to a diminished sense of self and identity. The link between autobiographical decline and compromised sense of self in AD can also manifest itself as low correspondence and coherence between past memories and current goals and beliefs. By linking cognitive, neuroanatomical, and clinical aspects of autobiographical decline in AD, our review provides a theoretical foundation, which may lead to better rehabilitation strategies. Copyright © 2015 Elsevier B.V. All rights reserved.

Dedup Est Machina : Memory Deduplication as an Advanced Exploitation Vector

NARCIS (Netherlands)

Bosman, Erik; Razavi, Kaveh; Bos, Herbert; Giuffrida, Cristiano

2016-01-01

Memory deduplication, a well-known technique to reduce the memory footprint across virtual machines, is now also a default-on feature inside the Windows 8.1 and Windows 10 operating systems. Deduplication maps multiple identical copies of a physical page onto a single shared copy with copy-on-write

The Roles of Working Memory and Cognitive Load in Geoscience Learning

Science.gov (United States)

Jaeger, Allison J.; Shipley, Thomas F.; Reynolds, Stephen J.

2017-01-01

Working memory is a cognitive system that allows for the simultaneous storage and processing of active information. While working memory has been implicated as an important element for success in many science, technology, engineering, and mathematics (STEM) fields, its specific role in geoscience learning is not fully understood. The major goal of…

Electrophysiological correlates of exemplar-specific processes in implicit and explicit memory.

Science.gov (United States)

Küper, Kristina; Groh-Bordin, Christian; Zimmer, Hubert D; Ecker, Ullrich K H

2012-03-01

The present ERP study investigated the retrieval of task-irrelevant exemplar-specific information under implicit and explicit memory conditions. Subjects completed either an indirect memory test (a natural/artificial judgment) or a direct recognition memory test. Both test groups were presented with new items, identical repetitions, and perceptually different but conceptually similar exemplars of previously seen study objects. Implicit and explicit memory retrieval elicited clearly dissociable ERP components that were differentially affected by exemplar changes from study to test. In the indirect test, identical repetitions, but not different exemplars, elicited a significant ERP repetition priming effect. In contrast, both types of repeated objects gave rise to a reliable old/new effect in the direct test. The results corroborate that implicit and explicit memory fall back on distinct cognitive representation and, more importantly, indicate that these representations differ in the type of stimulus information stored. Implicit retrieval entailed obligatory access to exemplar-specific perceptual information, despite its being task irrelevant. In contrast, explicit retrieval proved to be more flexible with conceptual and perceptual information accessed according to task demands.

jmzIdentML API: A Java interface to the mzIdentML standard for peptide and protein identification data.

Science.gov (United States)

Reisinger, Florian; Krishna, Ritesh; Ghali, Fawaz; Ríos, Daniel; Hermjakob, Henning; Vizcaíno, Juan Antonio; Jones, Andrew R

2012-03-01

We present a Java application programming interface (API), jmzIdentML, for the Human Proteome Organisation (HUPO) Proteomics Standards Initiative (PSI) mzIdentML standard for peptide and protein identification data. The API combines the power of Java Architecture of XML Binding (JAXB) and an XPath-based random-access indexer to allow a fast and efficient mapping of extensible markup language (XML) elements to Java objects. The internal references in the mzIdentML files are resolved in an on-demand manner, where the whole file is accessed as a random-access swap file, and only the relevant piece of XMLis selected for mapping to its corresponding Java object. The APIis highly efficient in its memory usage and can handle files of arbitrary sizes. The APIfollows the official release of the mzIdentML (version 1.1) specifications and is available in the public domain under a permissive licence at http://www.code.google.com/p/jmzidentml/. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chromatin Repressive Complexes in Stem Cells, Development, and Cancer

DEFF Research Database (Denmark)

Laugesen, Anne; Helin, Kristian

2014-01-01

The chromatin environment is essential for the correct specification and preservation of cell identity through modulation and maintenance of transcription patterns. Many chromatin regulators are required for development, stem cell maintenance, and differentiation. Here, we review the roles...

Does Echoic Memory Develop?

Science.gov (United States)

Engle, Randall W.; And Others

1981-01-01

To examine developmental aspects of auditory sensory memory, a series of experiments was conducted on the stimulus suffix effect with the primary variables being age of subject (7 and 11 years), rates of presentation, and length of list. Effects were nearly identical across age groups when a fast presentation rate was used. (Author/DB)

Mechanisms of Memory Retrieval in Slow-Wave Sleep

Science.gov (United States)

Cairney, Scott A; Sobczak, Justyna M; Lindsay, Shane

2017-01-01

Abstract Study Objectives Memories are strengthened during sleep. The benefits of sleep for memory can be enhanced by re-exposing the sleeping brain to auditory cues; a technique known as targeted memory reactivation (TMR). Prior studies have not assessed the nature of the retrieval mechanisms underpinning TMR: the matching process between auditory stimuli encountered during sleep and previously encoded memories. We carried out two experiments to address this issue. Methods In Experiment 1, participants associated words with verbal and nonverbal auditory stimuli before an overnight interval in which subsets of these stimuli were replayed in slow-wave sleep. We repeated this paradigm in Experiment 2 with the single difference that the gender of the verbal auditory stimuli was switched between learning and sleep. Results In Experiment 1, forgetting of cued (vs. noncued) associations was reduced by TMR with verbal and nonverbal cues to similar extents. In Experiment 2, TMR with identical nonverbal cues reduced forgetting of cued (vs. noncued) associations, replicating Experiment 1. However, TMR with nonidentical verbal cues reduced forgetting of both cued and noncued associations. Conclusions These experiments suggest that the memory effects of TMR are influenced by the acoustic overlap between stimuli delivered at training and sleep. Our findings hint at the existence of two processing routes for memory retrieval during sleep. Whereas TMR with acoustically identical cues may reactivate individual associations via simple episodic matching, TMR with nonidentical verbal cues may utilize linguistic decoding mechanisms, resulting in widespread reactivation across a broad category of memories. PMID:28934526

Mechanisms of Memory Retrieval in Slow-Wave Sleep.

Science.gov (United States)

Cairney, Scott A; Sobczak, Justyna M; Lindsay, Shane; Gaskell, M Gareth

2017-09-01

Memories are strengthened during sleep. The benefits of sleep for memory can be enhanced by re-exposing the sleeping brain to auditory cues; a technique known as targeted memory reactivation (TMR). Prior studies have not assessed the nature of the retrieval mechanisms underpinning TMR: the matching process between auditory stimuli encountered during sleep and previously encoded memories. We carried out two experiments to address this issue. In Experiment 1, participants associated words with verbal and nonverbal auditory stimuli before an overnight interval in which subsets of these stimuli were replayed in slow-wave sleep. We repeated this paradigm in Experiment 2 with the single difference that the gender of the verbal auditory stimuli was switched between learning and sleep. In Experiment 1, forgetting of cued (vs. noncued) associations was reduced by TMR with verbal and nonverbal cues to similar extents. In Experiment 2, TMR with identical nonverbal cues reduced forgetting of cued (vs. noncued) associations, replicating Experiment 1. However, TMR with nonidentical verbal cues reduced forgetting of both cued and noncued associations. These experiments suggest that the memory effects of TMR are influenced by the acoustic overlap between stimuli delivered at training and sleep. Our findings hint at the existence of two processing routes for memory retrieval during sleep. Whereas TMR with acoustically identical cues may reactivate individual associations via simple episodic matching, TMR with nonidentical verbal cues may utilize linguistic decoding mechanisms, resulting in widespread reactivation across a broad category of memories. © Sleep Research Society 2017. Published by Oxford University Press [on behalf of the Sleep Research Society].

Contesting history and identity formation in Paul and in South Africa

African Journals Online (AJOL)

2015-09-11

Sep 11, 2015 ... are false, but more in the sense of Benedict Anderson (1983:7), ... In social memory studies, Maurice Halbwachs (1980:12), a student of Emile Durkheim, notes ..... identity, Mr Geldenhuis is able to accentuate his emotional.

Can Web 2.0 shape meta-memory?

OpenAIRE

Sá, Alberto

2009-01-01

The social features of recent Web 2.0 technologies applications can bear a strong relationship to memory production and can help to shape personal identity through emotional connections by synchronizing people’s subjective experiences. When added to life, the proliferation of mechanical memory, experienced and produced by technology, makes for a new type of shared awareness. Therefore, we should look at these tools as instruments of reminiscence and as creative mnemonic aids. The input of ...

LA IMPLICANCIA DE LA MEMORIA Y LA IDENTIDAD EN LA CONSTITUCIÓN DEL PATRIMONIO. ALGUNAS REFLEXIONES / Some thoughts on the implications of memory and identity in the constitution of the patrimony.

Directory of Open Access Journals (Sweden)

María Belén Colasurdo

2010-12-01

Full Text Available En el presente trabajo se reflexiona acerca de la relación entre los conceptos de Memoria – Identidad – Patrimonio desde un enfoque antropológico. A partir de la ambigüedad intrínseca que caracteriza a los mismos, se considera el papel preponderante que juegan los mecanismos de memoria/olvido-identidades individuales/identidad colectiva en la elección de lo que será considerado patrimonio dentro de una comunidad. El concepto de patrimonio no ha sido el mismo a lo largo de la historia y su cambiante significado ha transitado, desde la idea inicial de tesoro ilustrado, hasta la de recurso turístico, pasando por su valoración como producto cultural y mecanismo de construcción de identidad. El museo es una de las instituciones que se encargan de determinar y perpetuar qué se considera patrimonio y qué no. El mismo puede representar bien o mal el pasado, puede distorsionarlo a partir de sus selecciones y clasificaciones, puede restringir el pasado a través de su código de representación histórica, la forma en que cuenta su historia, la forma en que son presentados los artefactos. Estos últimos son reunidos y presentados para generar un sentido particular para el visitante que los observa.Palabras clave: memoria; patrimonio; identidad; museo; antropología. AbstractThis paper is about the relation between the concepts of Memory – Identity – Patrimony from an anthropological focus. Since the intrinsic ambiguity of those concepts, it´s considered the preponderant role play by the mechanism of memory/oblivion-individual identities/collective identity in the choose of what it will be considered patrimony inside a community. The concept of patrimony have not been the same along the history and its changing meaning have evolve since the idea of an illustrated treasure to the idea of a touristic resource, and rating it as a cultural product and a mechanism of identity construction. The museum is one of the institution in charge of

Memory Loss and Retrieval

Science.gov (United States)

Reid, Ian

2016-01-01

Underlying the generally oblivious attitude of teachers and learners towards the past is insufficient respect for the role of memory in giving meaning to experience and access to knowledge. We shape our identity by making sense of our past and its relationship to present and future selves, a process that should be intensively cultivated when we…

Forms of Recall – Politics of Memory. Memory as the Non-Chronological Narrative Form of Historical-Political Identity Quest in the Kádár Regime and Its Survival in the Postcommunist Period

Directory of Open Access Journals (Sweden)

Gelencsér Gábor

2017-09-01

Full Text Available In the film art of the Kádár regime the modernist non-chronological narrative mode became the dominant form of remembrance and communicative memory. In the 35-year period between 1956 and 1990 we can find thirty-five films of this type (e.g. Dialogue [Párbeszéd, János Herskó, 1963], Twenty Hours [Húsz óra, Zoltán Fábri, 1965], Cold Days [Hideg napok, András Kovács, 1966], Love [Szerelem, Károly Makk, 1971], Lovefilm [Szerelmesfilm, István Szabó, 1970], Diary for My Children [Napló gyermekeimnek, Márta Mészáros, 1982], the majority of which thematize the communicative memory of the recent past of the period (World War II, the Hungarian Holocaust, the 1950s, 1956, the Kádár consolidation as opposed to the amnesia politics of the time. Although this cinematic corpus is connected to the film history of the Kádár era with all its elements (form: modernism; theme: communicative memory; political discourse: recollection; official politics of memory; the counterdiscourse of Kádár’s amnesia politics, it survives in the postcommunist period (e.g. Hungarian Fragment [Pannon töredék, András Sólyom, 1998], White Palms [Fehér tenyér, Szabolcs Hajdu, 2006], Mom and Other Loonies in the Family [Anyám és más futóbolondok a családból, Ibolya Fekete, 2015]. After presenting the non-chronological narrative form of historical-political identity quest, the paper seeks to find reasons for the survival of this form and tries to draw conclusions regarding the social aspect and modes of expression of the Hungarian film history of the postcommunist period.

The Power of the Past: The Use of Organizational Memory in the Building of Football Club’s

Directory of Open Access Journals (Sweden)

Alex Lopes Granja

2016-08-01

Full Text Available The memory is an important strategic asset and has been used gradually and indirectly in football clubs. For these roles, it plays and the present and future potential of the memory usage in football clubs is that the aim of this study is to identify how organizational memory can be used in building the identity of football clubs. As theoretical references were presented the organizational memory concepts, organizational identity, tradition of invention and nostalgia to understand how marketing departments of football clubs can use memory. They present also the consideration of the post-modern marketing and the retro marketing, which are the theories on marketing that essentially use memory. The methodology was qualitative exploratory with literature and in-depth interviews with consumers of the four largest fan clubs in the state of São Paulo. To analyze the data was used the technique of content analysis. The results presented in this study show the link between organizational memory and organizational identity, assisting in the targeting of marketing activities that are supported in aspects of the past to meet adequately the concerns of its consumers and serving to identify what the past and how the past should be commended.

Chromatin in embryonic stem cell neuronal differentiation.

Science.gov (United States)

Meshorer, E

2007-03-01

Chromatin, the basic regulatory unit of the eukaryotic genetic material, is controlled by epigenetic mechanisms including histone modifications, histone variants, DNA methylation and chromatin remodeling. Cellular differentiation involves large changes in gene expression concomitant with alterations in genome organization and chromatin structure. Such changes are particularly evident in self-renewing pluripotent embryonic stem cells, which begin, in terms of cell fate, as a tabula rasa, and through the process of differentiation, acquire distinct identities. Here I describe the changes in chromatin that accompany neuronal differentiation, particularly of embryonic stem cells, and discuss how chromatin serves as the master regulator of cellular destiny.

Retrieving fear memories, as time goes by…

Science.gov (United States)

Do Monte, Fabricio H.; Quirk, Gregory J.; Li, Bo; Penzo, Mario A.

2016-01-01

Fear conditioning researches have led to a comprehensive picture of the neuronal circuit underlying the formation of fear memories. In contrast, knowledge about the retrieval of fear memories is much more limited. This disparity may stem from the fact that fear memories are not rigid, but reorganize over time. To bring clarity and raise awareness on the time-dependent dynamics of retrieval circuits, we review current evidence on the neuronal circuitry participating in fear memory retrieval at both early and late time points after conditioning. We focus on the temporal recruitment of the paraventricular nucleus of the thalamus, and its BDNFergic efferents to the central nucleus of the amygdala, for the retrieval and maintenance of fear memories. Finally, we speculate as to why retrieval circuits change across time, and the functional benefits of recruiting structures such as the paraventricular nucleus into the retrieval circuit. PMID:27217148

Granulocyte Colony-stimulating Factor-primed Bone Marrow: An Excellent Stem-cell Source for Transplantation in Acute Myelocytic Leukemia and Chronic Myelocytic Leukemia

Directory of Open Access Journals (Sweden)

Yuhang Li

2015-01-01

Full Text Available Background: Steady-state bone marrow (SS-BM and granulocyte colony-stimulating growth factor-primed BM/peripheral blood stem-cell (G-BM/G-PBSC are the main stem-cell sources used in allogeneic hematopoietic stem-cell transplantation. Here, we evaluated the treatment effects of SS-BM and G-BM/G-PBSC in human leucocyte antigen (HLA-identical sibling transplantation. Methods: A total of 226 patients (acute myelogenous leukemia-complete remission 1, chronic myelogenous leukemia-chronic phase 1 received SS-BM, G-BM, or G-PBSC from an HLA-identical sibling. Clinical outcomes (graft-versus-host disease [GVHD], overall survival, transplant-related mortality [TRM], and leukemia-free survival [LFS] were analyzed. Results: When compared to SS-BM, G-BM gave faster recovery time to neutrophil or platelet (P 0.05. Conclusions: G-CSF-primed bone marrow shared the advantages of G-PBSC and SS-BM. We conclude that G-BM is an excellent stem-cell source that may be preferable to G-PBSC or SS-BM in patients receiving HLA-identical sibling hematopoietic stem-cell transplantation.

Autobiographical memory decline in Alzheimer’s disease, a theoretical and clinical overview

Science.gov (United States)

El Haj, Mohamad; Antoine, Pascal; Nandrino, Jean Louis; Kapogiannis, Dimitrios

2017-01-01

Autobiographical memory, or memory for personal experiences, allows individuals to define themselves and construct a meaningful life story. Decline of this ability, as observed in Alzheimer’s disease (AD), results in an impaired sense of self and identity. In our model (AMAD: Autobiographical Memory in Alzheimer’s Disease), we present a critical review of theories and findings regarding cognitive and neuroanatomical underpinnings of autobiographical memory and its decline in AD and highlight studies on its clinical rehabilitation. We propose that autobiographical recall in AD is mainly characterized by loss of associated episodic information, which leads to de-contextualization of autobiographical memories and a shift from reliving past events to a general sense of familiarity. This decline refers to retrograde, but also anterograde amnesia that affects newly acquired memories besides remote ones. One consequence of autobiographical memory decline in AD is decreased access to memories that shape self-consciousness, self-knowledge, and self-images, leading to a diminished sense of self and identity. The link between autobiographical decline and compromised sense of self in AD can also manifest itself as low correspondence and coherence between past memories and current goals and beliefs. By linking cognitive, neuroanatomical, and clinical aspects of autobiographical decline in AD, our review provides a theoretical foundation, which may lead to better rehabilitation strategies. PMID:26169474

Romanian Youths' Civic Identities: 20 Years after the Revolution

Science.gov (United States)

Obenchain, Kathryn; Bellows, Elizabeth; Bernat, Simona-Elena; Smith, Billy

2013-01-01

The study explores the civic identities of Romanian youth. Children born after 1989 have no memory of the communism; yet, they are the children and students of those who were educated under communism. Data sources were small group interviews with 21 youth and results indicate that participants believe "civic engagement is possible and…

Gestures, but Not Meaningless Movements, Lighten Working Memory Load when Explaining Math

Science.gov (United States)

Cook, Susan Wagner; Yip, Terina Kuangyi; Goldin-Meadow, Susan

2012-01-01

Gesturing is ubiquitous in communication and serves an important function for listeners, who are able to glean meaningful information from the gestures they see. But gesturing also functions for speakers, whose own gestures reduce demands on their working memory. Here we ask whether gesture's beneficial effects on working memory stem from its…

Social memory associated with estrogen receptor polymorphisms in women

Science.gov (United States)

Karlsson, Sara; Henningsson, Susanne; Hovey, Daniel; Zettergren, Anna; Jonsson, Lina; Cortes, Diana S.; Melke, Jonas; Laukka, Petri; Fischer, Håkan

2016-01-01

The ability to recognize the identity of faces and voices is essential for social relationships. Although the heritability of social memory is high, knowledge about the contributing genes is sparse. Since sex differences and rodent studies support an influence of estrogens and androgens on social memory, polymorphisms in the estrogen and androgen receptor genes (ESR1, ESR2, AR) are candidates for this trait. Recognition of faces and vocal sounds, separately and combined, was investigated in 490 subjects, genotyped for 10 single nucleotide polymorphisms (SNPs) in ESR1, four in ESR2 and one in the AR. Four of the associations survived correction for multiple testing: women carrying rare alleles of the three ESR2 SNPs, rs928554, rs1271572 and rs1256030, in linkage disequilibrium with each other, displayed superior face recognition compared with non-carriers. Furthermore, the uncommon genotype of the ESR1 SNP rs2504063 was associated with better recognition of identity through vocal sounds, also specifically in women. This study demonstrates evidence for associations in women between face recognition and variation in ESR2, and recognition of identity through vocal sounds and variation in ESR1. These results suggest that estrogen receptors may regulate social memory function in humans, in line with what has previously been established in mice. PMID:26955855

(Re)locating the gay Filipino: resistance, postcolonialism, and identity.

Science.gov (United States)

Manalansan, M F

1993-01-01

This paper attempts to critically analyze issues of postcolonial displacement, immigration, and homosexuality by examining the works of two Filipino gay immigrant writers, John Silva and Ralph Peña. Using postcolonial and critical theories, anthropological studies, and ethnographic fieldwork in New York City, this paper focuses on the role of language, memory, the body, race/ethnicity, and social class in the narrative strategies of the two writers. This paper argues that gay postcolonial writers such as these two relocate and reconfigure homosexual/gay identity in the face of new and oppressive hierarchies, identities, and practices.

Characterization of Self-Defining Memories in Individuals with Severe Alcohol Use Disorders After Mid-Term Abstinence: The Impact of the Emotional Valence of Memories.

Science.gov (United States)

Nandrino, Jean-Louis; Gandolphe, Marie-Charlotte

2017-08-01

Self-defining memories (SDM) are distinguished from other autobiographical memory (AM) processes to delineate those associated with the sense of personal identity and continuity in one's individual history. With chronic alcohol consumption, the construction of such memories may be modified in terms of specificity, valence, meaning-making, and evoked topics. This study sought to characterize SDM in a population of 27 patients with alcohol use disorder (AUD) who had been abstinent for at least 2 months compared with 28 control participants. Besides cognitive and clinical assessment, participants were told to describe verbally and date 5 SDM and their narratives were recorded. For each memory, 5 dimensions were evaluated: level of specificity, emotional valence, integration of meaning, topics, and distance of memory in time. Overall, SDM of participants with AUD were specifically characterized by (i) low specificity, (ii) low integration, (iii) a predominance of memories with negative emotional valence and a low frequency of positive memories, and (iv) a low frequency of topics related to success. When different dimensions of the SDM were crossed, their characteristics depended mainly on the valence of the memory. Negative memories were more frequent, more specific and more integrated, while positive SDM were less frequent, less specific and less integrated. The results underline the construction of a form of SDM with drinking problems that is mainly characterized by the disruption of positive memory and the presence of highly specific and integrated negative experiences. A disruption of the integration process modulated by the valence of memories could have repercussions on maintaining a sense of personal identity, the pursuit of personal goals and on social adaptability, and could constitute one of the main risks associated with persistent drinking problems. These results highlight the relevance of developing AM training programs for patients with AUD. Copyright �

Looking the Tiger in the Eye: Overcoming Fear-Based Teacher Identities

Science.gov (United States)

Wegwert, Joseph C.

2014-01-01

There has been a growing interest in and research on the construction of teachers' professional identity and parameters of practice among researchers worldwide. This piece examines the nature of teachers' perceptions about their professionalism and practice. It also explores teacher isolation stemming from assumptions related to…

Wena ungubani (Who are you)?: Post-1994 identity and memory ...

African Journals Online (AJOL)

space flows' afforded by the Internet and surfed by clans to (re) construct lost or muddled up genealogies. This discussion is set against the canvass of South Africa's post-1994 attempt at nation building where certain forms of memory, nostalgia and ...

Empowering Effective STEM Role Models to Promote STEM Equity in Local Communities

Science.gov (United States)

Harte, T.; Taylor, J.

2017-12-01

Empowering Effective STEM Role Models, a three-hour training developed and successfully implemented by NASA Langley Research Center's Science Directorate, is an effort to encourage STEM professionals to serve as role models within their community. The training is designed to help participants reflect on their identity as a role model and provide research-based strategies to effectively engage youth, particularly girls, in STEM (science, technology, engineering, and mathematics). Research shows that even though girls and boys do not demonstrate a significant difference in their ability to be successful in mathematics and science, there is a significant difference in their confidence level when participating in STEM subject matter and pursuing STEM careers. The Langley training model prepares professionals to disrupt this pattern and take on the habits and skills of effective role models. The training model is based on other successful models and resources for role modeling in STEM including SciGirls; the National Girls Collaborative; and publications by the American Association of University Women and the National Academies. It includes a significant reflection component, and participants walk through situation-based scenarios to practice a focused suite of research-based strategies. These strategies can be implemented in a variety of situations and adapted to the needs of groups that are underrepresented in STEM fields. Underpinning the training and the discussions is the fostering of a growth mindset and promoting perseverance. "The Power of Yet" becomes a means whereby role models encourage students to believe in themselves, working toward reaching their goals and dreams in the area of STEM. To provide additional support, NASA Langley role model trainers are available to work with a champion at other organizations to facilitate the training. This champion helps recruit participants, seeks leadership buy-in, and helps provide valuable insights for needs and

Trauma, Emotions and Memory in World Politics

DEFF Research Database (Denmark)

Pace, Michelle; Bilgic, Ali

2018-01-01

This article focuses on the impact of emotions on the European Union (EU)’s international identity and agency in the context of memory of trauma. Emotions are understood as performances through which an actor expresses itself to others while constructing its identity, creating its agency......, and potentially affecting the social order. It is argued that the memory of trauma is translated into EU foreign policy practice through emotional performances of EU representatives. Empirically, we explore this impact in relation to the EU’s engagement in the Israel-Palestinian prolonged conflict that has many...... underlying emotions linked with past traumatic experiences. By doing so we aim to instigate a discussion between the emotions literature in International Relations and the European Union studies literature to nuance understanding of the politics of emotions that increasingly constrain what kind of a global...

Two Rooms, Two Representations? Episodic-Like Memory in Toddlers and Preschoolers

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Newcombe, Nora S.; Balcomb, Frances; Ferrara, Katrina; Hansen, Melissa; Koski, Jessica

2014-01-01

Episodic memory involves binding together what-where-when associations. In three experiments, we tested the development of memory for such contextual associations in a naturalistic setting. Children searched for toys in two rooms with two different experimenters; each room contained two identical sets of four containers, but arranged differently.…

Measuring autobiographical fluency in the self-memory system.

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Rathbone, Clare J; Moulin, Chris J A

2014-01-01

Autobiographical memory is widely considered to be fundamentally related to concepts of self and identity. However, few studies have sought to test models of self and memory directly using experimental designs. Using a novel autobiographical fluency paradigm, the present study investigated memory accessibility for different levels of self-related knowledge. Forty participants generated 20 "I am" statements about themselves, from which the 1st, 5th, 10th, 15th, and 20th were used as cues in a two-minute autobiographical fluency task. The most salient aspects of the self, measured by both serial position and ratings of personal significance, were associated with more accessible sets of autobiographical memories. This finding supports theories that view the self as a powerful organizational structure in memory. Results are discussed with reference to models of self and memory.

Imagining and Remembering City: Memory, Space and Symbolism of Belgrade

Directory of Open Access Journals (Sweden)

Ljiljana Rogač Mijatović

2014-11-01

Full Text Available In contemporary “runaway world”, cities are becoming the main reference point of social life, change and development. The author discusses the complex process of articulating city identity and memory, as well as the meanings that arise in the interaction of memory, space and symbols of the city, within urban symbolism and cultural memory approach. What are the strategies of activating the cultural memory through multiple symbol bearers of the city, both tangible and intangible? The case study of the city of Belgrade indicates how the narratives related to memory and symbol bearers can be used in fostering culturally sustainable development of the city.

Antigen-Encoding Bone Marrow Terminates Islet-Directed Memory CD8+ T-Cell Responses to Alleviate Islet Transplant Rejection

DEFF Research Database (Denmark)

Coleman, Miranda; Jessup, Claire F.; Bridge, Jennifer A.

2016-01-01

in islet transplantation, and this will extend to application of personalized approaches using stem cell–derived replacement β-cells. New approaches are required to limit memory autoimmune attack of transplanted islets or replacement β-cells. Here, we show that transfer of bone marrow encoding cognate......Islet-specific memory T cells arise early in type 1 diabetes (T1D), persist for long periods, perpetuate disease, and are rapidly reactivated by islet transplantation. As memory T cells are poorly controlled by “conventional” therapies, memory T cell–mediated attack is a substantial challenge......-cell responses, and this can alleviate destruction of antigen-expressing islets. This addresses a key challenge facing islet transplantation and, importantly, the clinical application of personalized β-cell replacement therapies using patient-derived stem cells....

Autobiographic memory: phenomenological aspects, personal semantic knowledge, generic events and characters (one case of pure retrograde memory recovery).

Science.gov (United States)

Thomas Antérion, C; Mazzola, L; Laurent, B

2008-06-01

Tulving et al. [Brain Cogn 8 (1988) 3-20] proposed an operational distinction concerning memory between a semantic component consisting of general information about the individual's past and an episodic component, containing memories of specific events that can be situated in space and time. After a mild head trauma and in the context of professional troubles, patient FF displayed a pure retrograde amnesia concerning both his biographical identity and semantic memories. The patient could no longer access his memories. However, these did not seem completely lost since his answers to tests concerning historical events were better than random, his answers to a television quiz were automatic, he showed temporal transfer phenomena (ecmnesia) and since he retrieved the entirety of his memories within nine months. The patient FF illustrates the loss of retrograde autobiographic memory and the recovery of episodic memories, which requires three elements: a sense of subjective time, an autonoetic awareness (the ability to be aware of subjective time) and a "self" that can travel in subjective time.

The Categorical Structure of Semantic Memory for Famous People: A New Approach Using Release from Proactive Interference

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Darling, S.; Valentine, T.

2005-01-01

Memory for familiar people is essential to understand their identity and guide social interaction. Nevertheless, we know surprisingly little about the structure of such memory. Previous research has assumed that semantic memory for people has a categorical structure, but recently it was proposed that memory for people consists only of associations…

The semantic category-based grouping in the Multiple Identity Tracking task.

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Wei, Liuqing; Zhang, Xuemin; Li, Zhen; Liu, Jingyao

2018-01-01

In the Multiple Identity Tracking (MIT) task, categorical distinctions between targets and distractors have been found to facilitate tracking (Wei, Zhang, Lyu, & Li in Frontiers in Psychology, 7, 589, 2016). The purpose of this study was to further investigate the reasons for the facilitation effect, through six experiments. The results of Experiments 1-3 excluded the potential explanations of visual distinctiveness, attentional distribution strategy, and a working memory mechanism, respectively. When objects' visual information was preserved and categorical information was removed, the facilitation effect disappeared, suggesting that the visual distinctiveness between targets and distractors was not the main reason for the facilitation effect. Moreover, the facilitation effect was not the result of strategically shifting the attentional distribution, because the targets received more attention than the distractors in all conditions. Additionally, the facilitation effect did not come about because the identities of targets were encoded and stored in visual working memory to assist in the recovery from tracking errors; when working memory was disturbed by the object identities changing during tracking, the facilitation effect still existed. Experiments 4 and 5 showed that observers grouped targets together and segregated them from distractors on the basis of their categorical information. By doing this, observers could largely avoid distractor interference with tracking and improve tracking performance. Finally, Experiment 6 indicated that category-based grouping is not an automatic, but a goal-directed and effortful, strategy. In summary, the present findings show that a semantic category-based target-grouping mechanism exists in the MIT task, which is likely to be the major reason for the tracking facilitation effect.

Preserving the collective memory and re-creating identity through animation

DEFF Research Database (Denmark)

Carpe Pérez, Inmaculada Concepción; Pedersen, Hanne

of the autobiographic memory and documentary through animation techniques. When we produce an animated film, we can appreciate how the creation of characters and scenarios are transformed into visual metaphors, making possible the re-creation of past moments or the simulation of possible ones. We experience, thanks...

Impact of cyclophosphamide dose of conditioning on the outcome of allogeneic hematopoietic stem cell transplantation for aplastic anemia from human leukocyte antigen-identical sibling.

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Mori, Takehiko; Koh, Hideo; Onishi, Yasushi; Kako, Shinichi; Onizuka, Makoto; Kanamori, Heiwa; Ozawa, Yukiyasu; Kato, Chiaki; Iida, Hiroatsu; Suzuki, Ritsuro; Ichinohe, Tatsuo; Kanda, Yoshinobu; Maeda, Tetsuo; Nakao, Shinji; Yamazaki, Hirohito

2016-04-01

The standard conditioning regimen in allogeneic hematopoietic stem cell transplantation (HSCT) for aplastic anemia from a human leukocyte antigen (HLA)-identical sibling has been high-dose cyclophosphamide (CY 200 mg/kg). In the present study, results for 203 patients with aplastic anemia aged 16 years or older who underwent allogeneic HSCT from HLA-identical siblings were retrospectively analyzed using the registry database of Japan Society for Hematopoietic Cell Transplantation. Conditioning regimens were defined as a (1) high-dose CY (200 mg/kg or greater)-based (n = 117); (2) reduced-dose CY (100 mg/kg or greater, but less than 200 mg/kg)-based (n = 38); and (3) low-dose CY (less than 100 mg/kg)-based (n = 48) regimen. Patient age and the proportion of patients receiving fludarabine were significantly higher in the reduced- and low-dose CY groups than the high-dose CY group. Engraftment was comparable among the groups. Five-year overall survival (OS) tended to be higher in the low-dose CY group [93.0 % (95 % CI 85.1-100.0 %)] than the high-dose CY [84.2 % (95 % CI 77.1-91.3 %)] or reduced-dose CY groups [83.8 % (95 % CI 71.8-95.8 %); P = 0.214]. Age-adjusted OS was higher in the low-dose CY group than the high- and reduced-dose CY groups with borderline significance (P = 0.067). These results suggest that CY dose can safely be reduced without increasing graft rejection by adding fludarabine in allogeneic HSCT for aplastic anemia from an HLA-identical sibling.

The distribution and the functions of autobiographical memories: Why do older adults remember autobiographical memories from their youth?

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Wolf, Tabea; Zimprich, Daniel

2016-09-01

In the present study, the distribution of autobiographical memories was examined from a functional perspective: we examined whether the extent to which long-term autobiographical memories were rated as having a self-, a directive, or a social function affects the location (mean age) and scale (standard deviation) of the memory distribution. Analyses were based on a total of 5598 autobiographical memories generated by 149 adults aged between 50 and 81 years in response to 51 cue-words. Participants provided their age at the time when the recalled events had happened and rated how frequently they recall these events for self-, directive, and social purposes. While more frequently using autobiographical memories for self-functions was associated with an earlier mean age, memories frequently shared with others showed a narrower distribution around a later mean age. The directive function, by contrast, did not affect the memory distribution. The results strengthen the assumption that experiences from an individual's late adolescence serve to maintain a sense of self-continuity throughout the lifespan. Experiences that are frequently shared with others, in contrast, stem from a narrow age range located in young adulthood.

Memory systems, processes, and tasks: taxonomic clarification via factor analysis.

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Bruss, Peter J; Mitchell, David B

2009-01-01

The nature of various memory systems was examined using factor analysis. We reanalyzed data from 11 memory tasks previously reported in Mitchell and Bruss (2003). Four well-defined factors emerged, closely resembling episodic and semantic memory and conceptual and perceptual implicit memory, in line with both memory systems and transfer-appropriate processing accounts. To explore taxonomic issues, we ran separate analyses on the implicit tasks. Using a cross-format manipulation (pictures vs. words), we identified 3 prototypical tasks. Word fragment completion and picture fragment identification tasks were "factor pure," tapping perceptual processes uniquely. Category exemplar generation revealed its conceptual nature, yielding both cross-format priming and a picture superiority effect. In contrast, word stem completion and picture naming were more complex, revealing attributes of both processes.

Crystallization and preliminary X-ray diffraction analysis of a tRNASer acceptor-stem microhelix

International Nuclear Information System (INIS)

Förster, Charlotte; Krauss, Norbert; Brauer, Arnd B. E.; Szkaradkiewicz, Karol; Brode, Svenja; Hennig, Klaus; Fürste, Jens P.; Perbandt, Markus; Betzel, Christian; Erdmann, Volker A.

2006-01-01

In order to investigate tRNA identity elements, an elongator tRNA Ser acceptor-stem helix was crystallized and a data set was collected to 1.8 Å resolution aiming at a comparison with the corresponding region in suppressor tRNA Sec . In order to understand elongator tRNA Ser and suppressor tRNA Sec identity elements, the respective acceptor-stem helices have been synthesized and crystallized in order to analyse and compare their structures in detail at high resolution. The synthesis, crystallization and preliminary X-ray diffraction results for a seven-base-pair tRNA Ser acceptor-stem helix are presented here. Diffraction data were collected to 1.8 Å, applying synchrotron radiation and cryogenic cooling. The crystals belong to the monoclinic space group C2, with unit-cell parameters a = 36.14, b = 38.96, c = 30.81 Å, β = 110.69°

Imagining Geographies, Mapping Identities

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Matthew Graves

2015-03-01

Full Text Available The ambition of this issue of Portal is to reach across the methodological boundaries of history, politics, literature and geography to apply their complementary perspectives to the study of identity and its relation to space and place, an aim that involves attempting to identify the many different ways the notoriously slippery concepts of identity and geography may intersect. For this issue we have selected articles that cast a fresh perspective on two areas where identity and geography intersect: the construction of identity through the imaginative recreation of place in literature: Mapping Literary Spaces; and the study of the shifting relationships of centre and periphery, exclusion and inclusion in urban settings and geopolitical confrontations: Social and Political Peripheries. Gerard Toal has written that geography is not a noun but a verb: it does not describe what space is but studies what we do with space, imaginatively and politically. The articles in this issue illustrate the exercise of the literary and political imagination and the role of materiality and memory in the creation of geographic representation. They show too a new awareness of the centrality of space in the constitution of identities, and the need for a new geocritical reading of its discourse, as the interrelations of place and community are played out on the many scales of social and political life, from the local to the global.   The special issue is organised thus: Introduction Matthew Graves (Aix-Marseille University & Liz Rechniewski (Sydney University: “Imagining Geographies, Mapping Identities.” I. Mapping Literary Spaces - Isabelle Avila (University of Paris XIII, "Les Cartes de l'Afrique au XIXe siècle et Joseph Conrad : Perceptions d'une Révolution Cartographique." - Daniela Rogobete (University of Craiova, "Global vs Glocal: Dimensions of the post-1981 Indian English Novel." II. Social and Political Peripheries - Elizabeth Rechniewski (Sydney

Visual working memory is more tolerant than visual long-term memory.

Science.gov (United States)

Schurgin, Mark W; Flombaum, Jonathan I

2018-05-07

Human visual memory is tolerant, meaning that it supports object recognition despite variability across encounters at the image level. Tolerant object recognition remains one capacity in which artificial intelligence trails humans. Typically, tolerance is described as a property of human visual long-term memory (VLTM). In contrast, visual working memory (VWM) is not usually ascribed a role in tolerant recognition, with tests of that system usually demanding discriminatory power-identifying changes, not sameness. There are good reasons to expect that VLTM is more tolerant; functionally, recognition over the long-term must accommodate the fact that objects will not be viewed under identical conditions; and practically, the passive and massive nature of VLTM may impose relatively permissive criteria for thinking that two inputs are the same. But empirically, tolerance has never been compared across working and long-term visual memory. We therefore developed a novel paradigm for equating encoding and test across different memory types. In each experiment trial, participants saw two objects, memory for one tested immediately (VWM) and later for the other (VLTM). VWM performance was better than VLTM and remained robust despite the introduction of image and object variability. In contrast, VLTM performance suffered linearly as more variability was introduced into test stimuli. Additional experiments excluded interference effects as causes for the observed differences. These results suggest the possibility of a previously unidentified role for VWM in the acquisition of tolerant representations for object recognition. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Visual Working Memory Capacity for Emotional Facial Expressions

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Domagoj Švegar

2011-12-01

Full Text Available The capacity of visual working memory is limited to no more than four items. At the same time, it is limited not only by the number of objects, but also by the total amount of information that needs to be memorized, and the relation between the information load per object and the number of objects that can be stored into visual working memory is inverse. The objective of the present experiment was to compute visual working memory capacity for emotional facial expressions, and in order to do so, change detection tasks were applied. Pictures of human emotional facial expressions were presented to 24 participants in 1008 experimental trials, each of which began with a presentation of a fixation mark, which was followed by a short simultaneous presentation of six emotional facial expressions. After that, a blank screen was presented, and after such inter-stimulus interval, one facial expression was presented at one of previously occupied locations. Participants had to answer if the facial expression presented at test is different or identical as the expression presented at that same location before the retention interval. Memory capacity was estimated through accuracy of responding, by the formula constructed by Pashler (1988, adopted from signal detection theory. It was found that visual working memory capacity for emotional facial expressions equals 3.07, which is high compared to capacity for facial identities and other visual stimuli. The obtained results were explained within the framework of evolutionary psychology.

Reconstruction of Ethiopia's Collective Memory by Rewriting its History : The Politics of Islam

NARCIS (Netherlands)

Nega Angore, T.

2017-01-01

The dynamics of constructing collective memory in relation to the politics of Muslim identity form the subject matter of this research. It explores how the state and the Muslim activists agitate and reinforce a meta-political narrative among Ethiopian Muslim communities to harness collective memory.

New insights into mechanisms of stem cell daughter fate determination in regenerative tissues.

Science.gov (United States)

Sada, Aiko; Tumbar, Tudorita

2013-01-01

Stem cells can self-renew and differentiate over extended periods of time. Understanding how stem cells acquire their fates is a central question in stem cell biology. Early work in Drosophila germ line and neuroblast showed that fate choice is achieved by strict asymmetric divisions that can generate each time one stem and one differentiated cell. More recent work suggests that during homeostasis, some stem cells can divide symmetrically to generate two differentiated cells or two identical stem cells to compensate for stem cell loss that occurred by direct differentiation or apoptosis. The interplay of all these factors ensures constant tissue regeneration and the maintenance of stem cell pool size. This interplay can be modeled as a population-deterministic dynamics that, at least in some systems, may be described as stochastic behavior. Here, we overview recent progress made on the characterization of stem cell dynamics in regenerative tissues. Copyright © 2013 Elsevier Inc. All rights reserved.

Toward reliable and repeatable automated STEM-EDS metrology with high throughput

Science.gov (United States)

Zhong, Zhenxin; Donald, Jason; Dutrow, Gavin; Roller, Justin; Ugurlu, Ozan; Verheijen, Martin; Bidiuk, Oleksii

2018-03-01

New materials and designs in complex 3D architectures in logic and memory devices have raised complexity in S/TEM metrology. In this paper, we report about a newly developed, automated, scanning transmission electron microscopy (STEM) based, energy dispersive X-ray spectroscopy (STEM-EDS) metrology method that addresses these challenges. Different methodologies toward repeatable and efficient, automated STEM-EDS metrology with high throughput are presented: we introduce the best known auto-EDS acquisition and quantification methods for robust and reliable metrology and present how electron exposure dose impacts the EDS metrology reproducibility, either due to poor signalto-noise ratio (SNR) at low dose or due to sample modifications at high dose conditions. Finally, we discuss the limitations of the STEM-EDS metrology technique and propose strategies to optimize the process both in terms of throughput and metrology reliability.

Outcomes and Processes in the Meyerhoff Scholars Program: STEM PhD Completion, Sense of Community, Perceived Program Benefit, Science Identity, and Research Self-Efficacy.

Science.gov (United States)

Maton, Kenneth I; Beason, Tiffany S; Godsay, Surbhi; Sto Domingo, Mariano R; Bailey, TaShara C; Sun, Shuyan; Hrabowski, Freeman A

2016-01-01

Previous research has shown that the Meyerhoff Scholars Program at the University of Maryland, Baltimore County, is an effective intervention for high-achieving underrepresented minority (URM) students; African-American Meyerhoff students are significantly more likely to enter science, technology, engineering, and mathematics (STEM) PhD programs than comparison students. The first of two studies in this report extends the prior research by examining levels of PhD completion for Meyerhoff (N = 479) versus comparison sample (N = 249) students among the first 16 cohorts. Entering African-American Meyerhoff students were 4.8 times more likely to complete STEM PhDs than comparison sample students. To enhance understanding of potential mechanisms of influence, the second study used data from the 22nd (Fall 2010) to 25th (Fall 2013) cohorts (N = 109) to test the hypothesis that perceived program benefit at the end of freshman year would mediate the relationship between sense of community at the end of Summer Bridge and science identity and research self-efficacy at the end of sophomore year. Study 2 results indicated that perceived program benefit fully mediated the relationship between sense of community and both criterion measures. The findings underscore the potential of comprehensive STEM intervention programs to enhance PhD completion, and suggest mechanisms of influence. © 2016 K. I. Maton et al. CBE—Life Sciences Education © 2016 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

Infants' long-term memory for a serial list: recognition and reactivation.

Science.gov (United States)

Gulya, M; Galluccio, L; Wilk, A; Rovee-Collier, C

2001-04-01

Serial lists contain information about item identity and item order. Using a task designed for nonverbal animals, we previously found that 3- and 6-month-olds exhibited a primacy effect after 24 hr, remembering both item identity and item order. Presently, we examined their memory of list information after longer delays. In Experiment 1, the serial-position curve reverted to a U-shape after 1 week at both ages, revealing that the common practice of attributing primacy and recency effects to long- and short-term memory, respectively, is flawed. In Experiment 2, a precuing procedure confirmed that 6-month-olds' memory still contained order information after 1 week, but 3-month-olds' reactivated memory contained none. Experiments 3A and 3B confirmed that increasing the complexity of information that was learned shortened the delay after which it could be retrieved. Testing infants after delays longer than have previously been used with animals or human adults sheds new light on an old phenomenon. Copyright 2001 John Wiley & Sons, Inc.

Co-infusion of haplo-identical CD19-chimeric antigen receptor T cells and stem cells achieved full donor engraftment in refractory acute lymphoblastic leukemia

Directory of Open Access Journals (Sweden)

Bo Cai

2016-11-01

Full Text Available Abstract Background Elderly patients with relapsed and refractory acute lymphoblastic leukemia (ALL have poor prognosis. Autologous CD19 chimeric antigen receptor-modified T (CAR-T cells have potentials to cure patients with B cell ALL; however, safety and efficacy of allogeneic CD19 CAR-T cells are still undetermined. Case presentation We treated a 71-year-old female with relapsed and refractory ALL who received co-infusion of haplo-identical donor-derived CD19-directed CAR-T cells and mobilized peripheral blood stem cells (PBSC following induction chemotherapy. Undetectable minimal residual disease by flow cytometry was achieved, and full donor cell engraftment was established. The transient release of cytokines and mild fever were detected. Significantly elevated serum lactate dehydrogenase, alanine transaminase, bilirubin and glutamic-oxalacetic transaminase were observed from days 14 to 18, all of which were reversible after immunosuppressive therapy. Conclusions Our preliminary results suggest that co-infusion of haplo-identical donor-derived CAR-T cells and mobilized PBSCs may induce full donor engraftment in relapsed and refractory ALL including elderly patients, but complications related to donor cell infusions should still be cautioned. Trial registration Allogeneic CART-19 for Elderly Relapsed/Refractory CD19+ ALL. NCT02799550

Anti-Memorials and the Art of Forgetting: Critical Reflections on a Memorial Design Practice

Directory of Open Access Journals (Sweden)

SueAnne Ware

2008-08-01

Full Text Available Andreas Huyssen writes, ‘Remembrance as a vital human activity shapes our links to the past, and the ways we remember define us in the present. As individuals and societies, we need the past to construct and to anchor our identities and to nurture a vision of the future.’ Memory is continually affected by a complex spectrum of states such as forgetting, denial, repression, trauma, recounting and reconsidering, stimulated by equally complex changes in context and changes over time. The apprehension and reflective comprehension of landscape is similarly beset by such complexities. Just as the nature and qualities of memory comprise inherently fading, shifting and fleeting impressions of things which are themselves ever-changing, an understanding of a landscape, as well as the landscape itself, is a constantly evolving, emerging response to both immense and intimate influences. There is an incongruity between the inherent changeability of both landscapes and memories, and the conventional, formal strategies of commemoration that typify the constructed landscape memorial. The design work presented in this paper brings together such explorations of memory and landscape by examining the ‘memorial’. This article examines two projects. One concerns the fate of illegal refugees travelling to Australia: The SIEVX Memorial Project. The other, An Anti-Memorial to Heroin Overdose Victims, was designed by the author as part of the 2001 Melbourne Festival.

Action identity: evidence from self-recognition, prediction, and coordination.

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Knoblich, Günther; Flach, Rüdiger

2003-12-01

Prior research suggests that the action system is responsible for creating an immediate sense of self by determining whether certain sensations and perceptions are the result of one's own actions. In addition, it is assumed that declarative, episodic, or autobiographical memories create a temporally extended sense of self or some form of identity. In the present article, we review recent evidence suggesting that action (procedural) knowledge also forms part of a person's identity, an action identity, so to speak. Experiments that addressed self-recognition of past actions, prediction, and coordination provide ample evidence for this assumption. The phenomena observed in these experiments can be explained by the assumption that observing an action results in the activation of action representations, the more so, when the action observed corresponds to the way in which the observer would produce it.

Word-stem priming and recognition in type 2 diabetes mellitus, Alzheimer's disease patients and healthy older adults.

Science.gov (United States)

Redondo, María Teresa; Beltrán-Brotóns, José Luís; Reales, José Manuel; Ballesteros, Soledad

2015-11-01

The present study investigated (a) whether the pattern of performance on implicit and explicit memory of patients with type 2 diabetes mellitus (DM2) is more similar to those of patients with Alzheimer's disease (AD) or to cognitively normal older adults and (b) whether glycosylated hemoglobin levels (a measure of glucose regulation) are related to performance on the two memory tasks, implicit word-stem completion and "old-new" recognition. The procedures of both memory tasks included encoding and memory test phases separated by a short delay. Three groups of participants (healthy older adults, DM2 patients and AD patients) completed medical and psychological assessments and performed both memory tasks on a computer. The results of the word-stem completion task showed similar implicit memory in the three groups. By contrast, explicit recognition of the three groups differed. Implicit memory was not affected by either normal or pathological aging, but explicit memory deteriorated in the two groups of patients, especially in AD patients, showing a severe impairment compared to the cognitively healthy older adults. Importantly, glycosylated hemoglobin levels were not related to performance on either implicit or explicit memory tasks. These findings revealed a clear dissociation between explicit and implicit memory tasks in normal and pathological aging. Neuropsychologists and clinicians working with TM2 patients should be aware that the decline of voluntary, long-term explicit memory could have a negative impact on their treatment management. By contrast, the intact implicit memory of the two clinical groups could be used in rehabilitation.

In vitro generation of Epstein-Barr virus-specific cytotoxic T cells in patients receiving haplo-identical allogeneic stem cell transplantation.

Science.gov (United States)

Musk, P; Szmania, S; Galloway, A T; Johnson, K; Scott, A; Guttman, S; Bridges, K; Bruorton, M; Gatlin, J; Garcia, J V; Lamb, L; Chiang, K Y; Spencer, T; Henslee-Downey, J; van Rhee, F

2001-01-01

Use of a partially mismatched related donor (PMRD) is an option for patients who require allogeneic transplantation but do not have a matched sibling or unrelated donor. Epstein-Barr virus (EBV)-induced lymphoma is a major cause of mortality after PMRD transplantation. In this study, we present a clinical grade culture system for donor-derived EBV-specific cytotoxic T cells (CTLs) that do not recognize haplo-identical recipient cells. The EBV-specific CTLs were tested for cytolytic specificity and other functional properties, including ability to transgress into tissues, propensity for apoptosis, degree of clonality, stability of dominant T-cell clones, and Tc and Th phenotypes. The EBV-specific CTLs were routinely expanded to greater than 80 x 10(6) over a period of 5 weeks, which is sufficient for clinical application. A CD8+ phenotype predominated, and the CTLs were highly specific for donor lymphoblastoid cell lines (LCLs) without killing of recipient targets or K562. Vbeta spectratyping showed an oligoclonal population that was stable on prolonged culture. The EBV-specific CTLs were activated (D-related human leukocyte antigen [HLA-DR+], L-selectin+/-) and of memory phenotype (CD45RO+). Expression of the integrin VLA-4 suggested that these CTLs could adhere to endothelium and migrate into tissues. The Bcl-2 message was upregulated, which may protect the CTLs from the apoptosis. The first demonstration of overexpression of bcl-2 in human memory CTLs. In addition, we show that lymphoblastoid cell lines used to generate CTLs are readily genetically modified with recombinant lentivirus, indicating that genetically engineered antigen presentation is feasible.

Identity politics: implications for gender analysis policy and training.

Science.gov (United States)

Erturk, Y

1997-01-01

As attention has shifted from a concern for citizenship, equality, and welfare to ideas of empowerment, equity, and governance, the locus of competition over power has rested with "identity politics," a recognition of cultural diversity that claims the legitimate right to produce alternative definitions and symbols of identity in public space. The change in identity formation from universal/national to fractured/tribalizing has implications for gender relations in contexts where patriarchal power controls production and reproduction. Except for feminism, all discourses in the current competition over identity politics are patriarchal. A look at the forces of change that shifted the process of modernization to a process of globalization reveals that, while modernization tends to standardize, globalization embraces the contradictory forces of universalizing and diversifying trends. Issues of identity and inequality were not problematic until the modern and the traditional subsumed each other and, thus, revealed the inherent contradictions of modernization. The diversifying forces that jeopardize the transnationalization of identity into membership in a "human society" include 1) language differences among the working classes, 2) growing global inequalities, and 3) collective memories of antagonistic histories. An analysis of gender based on identity politics can be conducted on a macro-level to understand the reluctance of central governments to initiate certain interventions, competing needs, new contradictions, changing gender roles, and the importance of promoting a global social contract.

The cellular memory disc of reprogrammed cells.

Science.gov (United States)

Anjamrooz, Seyed Hadi

2013-04-01

The crucial facts underlying the low efficiency of cellular reprogramming are poorly understood. Cellular reprogramming occurs in nuclear transfer, induced pluripotent stem cell (iPSC) formation, cell fusion, and lineage-switching experiments. Despite these advances, there are three fundamental problems to be addressed: (1) the majority of cells cannot be reprogrammed, (2) the efficiency of reprogramming cells is usually low, and (3) the reprogrammed cells developed from a patient's own cells activate immune responses. These shortcomings present major obstacles for using reprogramming approaches in customised cell therapy. In this Perspective, the author synthesises past and present observations in the field of cellular reprogramming to propose a theoretical picture of the cellular memory disc. The current hypothesis is that all cells undergo an endogenous and exogenous holographic memorisation such that parts of the cellular memory dramatically decrease the efficiency of reprogramming cells, act like a barrier against reprogramming in the majority of cells, and activate immune responses. Accordingly, the focus of this review is mainly to describe the cellular memory disc (CMD). Based on the present theory, cellular memory includes three parts: a reprogramming-resistance memory (RRM), a switch-promoting memory (SPM) and a culture-induced memory (CIM). The cellular memory arises genetically, epigenetically and non-genetically and affects cellular behaviours. [corrected].

Self and identity in borderline personality disorder: Agency and mental time travel.

Science.gov (United States)

Gold, Natalie; Kyratsous, Michalis

2017-10-01

We consider how conceptions of the self and identity from the philosophical literature can help us to understand identity disturbance in borderline personality disorder (BPD). We present 3 philosophical approaches: connectedness, narrative, and agency. We show how these map on to 3 different ways in which the self can be temporally extended. The connectedness approach is dominant in philosophy, and the narrative approach has been used by psychiatry, but we argue that the lesser-known agency approach provides a promising way to theorize some aspects of identity disturbance in BPD. It relates the 2 diagnostic criteria of identity disturbance and disinhibition and is consistent with evidence of memory deficits and altered self-processing in BPD patients. © 2017 The Authors. Journal of Evaluation in Clinical Practice Published by John Wiley & Sons Ltd.

Past-life identities, UFO abductions, and satanic ritual abuse: the social construction of memories.

Science.gov (United States)

Spanos, N P; Burgess, C A; Burgess, M F

1994-10-01

People sometimes fantasize entire complex scenarios and later define these experiences as memories of actual events rather than as imaginings. This article examines research associated with three such phenomena: past-life experiences, UFO alien contact and abduction, and memory reports of childhood ritual satanic abuse. In each case, elicitation of the fantasy events is frequently associated with hypnotic procedures and structured interviews which provide strong and repeated demands for the requisite experiences, and which then legitimate the experiences as "real memories." Research associated with these phenomena supports the hypothesis that recall is reconstructive and organized in terms of current expectations and beliefs.

Musical identity of patients with multiple sclerosis.

Science.gov (United States)

Moreira, Shirlene Vianna; França, Cecília Cavalieri; Moreira, Marcos Aurélio; Lana-Peixoto, Marco Aurélio

2009-03-01

Musical autobiographies consist of a powerful therapeutic tool by which individuals define themselves. The use of this technique may help (re)construction personal identities and improve quality of life of patients with multiple sclerosis (MS). Eight adult patients on treatment at CIEM Multiple Sclerosis Investigation Center after selecting 10 to 15 pieces of music most significant in their lives were interviewed. The data collected were classified according to Even Rudd categories, which reveal how a person expresses his personal, social, temporal and transpersonal identities. We observed that recall of musical history makes MS patients get better perception both of their feelings and body awareness, as well as provide them with an alternative way to express themselves, activate and contextualize affective memories, and achieving a sense of life continuity in spite of the disease.

Facial Expression at Retrieval Affects Recognition of Facial Identity

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Wenfeng eChen

2015-06-01

Full Text Available It is well known that memory can be modulated by emotional stimuli at the time of encoding and consolidation. For example, happy faces create better identity recognition than faces with certain other expressions. However, the influence of facial expression at the time of retrieval remains unknown in the literature. To separate the potential influence of expression at retrieval from its effects at earlier stages, we had participants learn neutral faces but manipulated facial expression at the time of memory retrieval in a standard old/new recognition task. The results showed a clear effect of facial expression, where happy test faces were identified more successfully than angry test faces. This effect is unlikely due to greater image similarity between the neutral learning face and the happy test face, because image analysis showed that the happy test faces are in fact less similar to the neutral learning faces relative to the angry test faces. In the second experiment, we investigated whether this emotional effect is influenced by the expression at the time of learning. We employed angry or happy faces as learning stimuli, and angry, happy, and neutral faces as test stimuli. The results showed that the emotional effect at retrieval is robust across different encoding conditions with happy or angry expressions. These findings indicate that emotional expressions affect the retrieval process in identity recognition, and identity recognition does not rely on emotional association between learning and test faces.

Research progress in animal models and stem cell therapy for Alzheimer’s disease

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Han F

2014-12-01

Full Text Available Fabin Han,1,2 Wei Wang1, Chao Chen1 1Centre for Stem Cells and Regenerative Medicine, 2Department of Neurology, Liaocheng People’s Hospital/The Affiliated Liaocheng Hospital, Taishan Medical University, Shandong, People’s Republic of China Abstract: Alzheimer’s disease (AD causes degeneration of brain neurons and leads to memory loss and cognitive impairment. Since current therapeutic strategies cannot cure the disease, stem cell therapy represents a powerful tool for the treatment of AD. We first review the advances in molecular pathogenesis and animal models of AD and then discuss recent clinical studies using small molecules and immunoglobulins to target amyloid-beta plaques for AD therapy. Finally, we discuss stem cell therapy for AD using neural stem cells, olfactory ensheathing cells, embryonic stem cells, and mesenchymal stem cell from bone marrow, umbilical cord, and umbilical cord blood. In particular, patient-specific induced pluripotent stem cells are proposed as a future treatment for AD. Keywords: amyloid-beta plaque, neurofibrillary tangle, neural stem cell, olfactory ensheathing cell, mesenchymal stem cell, induced pluripotent stem cell

Identity's identities

DEFF Research Database (Denmark)

Jensen, Kim Ebensgaard

-specialized language in which it also serves a number of functions – some of which are quite fundamental to society as such. In other words, the lexeme identity is a polysemic word and has multiple, well, identities. Given that it appears to have a number of functions in a variety of registers, including terminologies...... in Academic English and more everyday-based English, identity as a lexeme is definitely worth having a look at. This paper presents a lexicological study of identity in which some of its senses are identified and their behaviors in actual discourse are observed. Drawing on data from the 2011 section...... of the Corpus of Contemporary American English, a behavioral profile of the distributional characteristics of identity is set up. Behavioral profiling is a lexicographical method developed by the corpus linguist Stefan Th. Gries which, by applying semantic ID tagging and statistical analysis, provides a fine...

A Longitudinal Study of How Quality Mentorship and Research Experience Integrate Underrepresented Minorities into STEM Careers.

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Estrada, Mica; Hernandez, Paul R; Schultz, P Wesley

2018-01-01

African Americans, Latinos, and Native Americans are historically underrepresented minorities (URMs) among science, technology, engineering, and mathematics (STEM) degree earners. Viewed from a perspective of social influence, this pattern suggests that URMs do not integrate into the STEM academic community at the same rate as non-URM students. Estrada and colleagues recently showed that Kelman's tripartite integration model of social influence (TIMSI) predicted URM persistence into science fields. In this paper, we longitudinally examine the integration of URMs into the STEM community by using growth-curve analyses to measure the development of TIMIS's key variables (science efficacy, identity, and values) from junior year through the postbaccalaureate year. Results showed that quality mentorship and research experience occurring in the junior and senior years were positively related to student science efficacy, identity, and values at that same time period. Longitudinal modeling of TIMSI further shows that, while efficacy is important, and perhaps a necessary predictor of moving toward a STEM career, past experiences of efficacy may not be sufficient for maintaining longer-term persistence. In contrast, science identity and values do continue to be predictive of STEM career pathway persistence up to 4 years after graduation. © 2018 M. Estrada et al. CBE—Life Sciences Education © 2018 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

Adult age differences in perceptually based, but not conceptually based implicit tests of memory.

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Small, B J; Hultsch, D F; Masson, M E

1995-05-01

Implicit tests of memory assess the influence of recent experience without requiring awareness of remembering. Evidence concerning age differences on implicit tests of memory suggests small age differences in favor of younger adults. However, the majority of research examining this issue has relied upon perceptually based implicit tests. Recently, a second type of implicit test, one that relies upon conceptually based processes, has been identified. The pattern of age differences on this second type of implicit test is less clear. In the present study, we examined the pattern of age differences on one conceptually based (fact completion) and one perceptually based (stem completion) implicit test of memory, as well as two explicit tests of memory (fact and word recall). Tasks were administered to 403 adults from three age groups (19-34 years, 58-73 years, 74-89 years). Significant age differences in favor of the young were found on stem completion but not fact completion. Age differences were present for both word and fast recall. Correlational analyses examining the relationship of memory performance to other cognitive variables indicated that the implicit tests were supported by different components than the explicit tests, as well as being different from each other.

Age differences in implicit memory: more apparent than real.

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Russo, R; Parkin, A J

1993-01-01

Elderly subjects and a group of young subjects identified fragmented picture sequences under conditions of focused attention. Two other groups of young subjects carried out this task under divided-attention conditions. Implicit memory, as measured by item-specific savings, was found in all groups, but this effect was smaller in the elderly group. The young subjects, but not elderly subjects, performed better on new items. The divided-attention conditions equated recall and recognition by the young and the elderly, but only the young subjects showed greater savings for recalled items. The elderly subjects' reduced implicit memory therefore stemmed from their inability to facilitate implicit memory with explicit memory. A second experiment, involving only young subjects tested after delay, produced findings similar to those for the young divided-attention subjects. Implicit memory, as measured by savings in picture completion, does not show an age-related change when the role of explicit memory is considered. Age does, however, reduce skill learning.

The identity impairment model: a longitudinal study of self-schemas as predictors of disordered eating behaviors.

Science.gov (United States)

Stein, Karen Farchaus; Corte, Colleen

2008-01-01

There is broad consensus that the eating disorders of anorexia nervosa and bulimia nervosa stem from fundamental disturbances in identity development, but theoretically based empirical support is lacking. To extend work on the identity impairment model by investigating the relationship between organizational properties of the self-concept and change in disordered eating behaviors (DEB) in an at-risk sample of college women transitioning between freshman and sophomore years. The number, valence, and organization of self-schemas; availability of a fat body weight self-schema; and DEB were measured at baseline in the freshman year and 6 and 12 months later in a community-based sample of college women engaged in subthreshold DEB (n = 77; control: n = 41). Repeated-measures analyses of variances were used to examine group differences, and hierarchical regression analyses were used to predict disordered eating behaviors. Women in the DEB group had more negative self-schemas at baseline and showed information-processing evidence of a fat self-schema compared with the controls. The groups did not differ in the number of positive self-schemas or interrelatedness. The number of negative self-schemas predicted increases in the level of DEB at 6- and 12-month follow-up, and these effects were mediated through the fat self-schema. The number of positive self-schemas predicted the fat self-schema score but was not predictive of increases in DEB. Interrelatedness of the self-concept was not a significant predictor in this model. Impairments in overall collection of identities are predictive of the availability in memory of a fat self-schema, which in turn is predictive of increases in DEB during the transition to college in a sample of women at risk for an eating disorder. Therefore, organizational properties of the self-concept may be an important focus for effective primary and secondary prevention.

Historical Contemporaneity and Contemporaneous Historicity: Creation of Meaning and Identity in Postwar Trauma Narratives

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Thorsten Wilhelm

2017-11-01

Full Text Available This paper contends that traumatic memories are not inherently memories of an experienced trauma. It explores a new perspective on post-1945 Jewish-American fiction. Analyzing Jewish-American novels from three generations—survivors, their children, and their grandchildren—the author traces the trajectories and changing perspectives in the narrative productions of these three generations. The analysis uses Jeffrey Alexander’s theory of cultural trauma to analyze generational trajectories in identity formations.

Strategic Self-Presentation of Women in STEM

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Alexandra Garr-Schultz

2018-01-01

Full Text Available Despite a plethora of initiatives and a surge of research activity, women remain under-represented in science, technology, engineering, and mathematics (STEM disciplines (National Science Foundation 2017. While much research has focused on ways to recruit women into these disciplines, less work has explored the strategies women use to navigate these contexts once they have entered. In a set of two experimental studies, we investigate women’s potential response strategies to the well-documented tension between female and STEM attributes in terms of individual self-presentation. In Study 1 (N = 240, we examine whether female STEM professionals have different impression goals when introducing themselves to professional peers versus a group of other women. In Study 2 (N = 169, we extend our inquiry to include self-presentation behavior as well as intentions. Across studies, we find that female STEM professionals hold different impression goals based on the audience with whom and context in which they expect to interact. These intentions align with actual self-introduction behavior, as observed in written self-introductions. Tuning one’s self-presentation, however, leads participants to feel less authentic. This work highlights one way women in male-dominated STEM contexts may navigate and strategically communicate their female and STEM identities to others, as well as the personal implications of doing so.

Autobiographical memory decline in Alzheimer���s disease, a theoretical and clinical overview

OpenAIRE

El Haj, Mohamad; Antoine, Pascal; Nandrino, Jean Louis; Kapogiannis, Dimitrios

2015-01-01

Autobiographical memory, or memory for personal experiences, allows individuals to define themselves and construct a meaningful life story. Decline of this ability, as observed in Alzheimer���s disease (AD), results in an impaired sense of self and identity. In our model (AMAD: Autobiographical Memory in Alzheimer���s Disease), we present a critical review of theories and findings regarding cognitive and neuroanatomical underpinnings of autobiographical memory and its decline in AD and highli...

A potential spatial working memory training task to improve both episodic memory and fluid intelligence.

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Sarah R Rudebeck

Full Text Available One current challenge in cognitive training is to create a training regime that benefits multiple cognitive domains, including episodic memory, without relying on a large battery of tasks, which can be time-consuming and difficult to learn. By giving careful consideration to the neural correlates underlying episodic and working memory, we devised a computerized working memory training task in which neurologically healthy participants were required to monitor and detect repetitions in two streams of spatial information (spatial location and scene identity presented simultaneously (i.e. a dual n-back paradigm. Participants' episodic memory abilities were assessed before and after training using two object and scene recognition memory tasks incorporating memory confidence judgments. Furthermore, to determine the generalizability of the effects of training, we also assessed fluid intelligence using a matrix reasoning task. By examining the difference between pre- and post-training performance (i.e. gain scores, we found that the trainers, compared to non-trainers, exhibited a significant improvement in fluid intelligence after 20 days. Interestingly, pre-training fluid intelligence performance, but not training task improvement, was a significant predictor of post-training fluid intelligence improvement, with lower pre-training fluid intelligence associated with greater post-training gain. Crucially, trainers who improved the most on the training task also showed an improvement in recognition memory as captured by d-prime scores and estimates of recollection and familiarity memory. Training task improvement was a significant predictor of gains in recognition and familiarity memory performance, with greater training improvement leading to more marked gains. In contrast, lower pre-training recollection memory scores, and not training task improvement, led to greater recollection memory performance after training. Our findings demonstrate that practice

Negative autobiographical memories in social anxiety disorder: A comparison with panic disorder and healthy controls.

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O'Toole, Mia Skytte; Watson, Lynn A; Rosenberg, Nicole K; Berntsen, Dorthe

2016-03-01

Empirical interest in mental imagery in social anxiety disorder (SAD) has grown over the past years but still little is known about the specificity to SAD. The present study therefore examines negative autobiographical memories in participants with social anxiety disorder (SAD), compared to patients with panic disorder (PD), and healthy controls (HCs). A total of 107 participants retrieved four memories cued by verbal phrases associated with either social anxiety (SA) or panic anxiety (PA), with two memories for each cue category. PA-cued memories were experienced with stronger imagery and as more traumatic. They were also rated as more central to identity than SA-cued memories, but not among participants with SAD, who perceived SA-cued memories as equally central to their identity. When between-group effects were detected, participants with anxiety disorders differed from HCs, but not from each other. Central limitations include reliance on self-report measures, comorbidity in the anxiety disorder groups, and lack of a neutrally cued memory comparison. The findings align with models of SAD suggesting that past negative social events play a central role in this disorder. Future research is suggested to further explore the function of negative memories, not only in SAD, but also in other anxiety disorders. Copyright © 2015 Elsevier Ltd. All rights reserved.

MacWilliams Identity for M-Spotty Weight Enumerator

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Suzuki, Kazuyoshi; Fujiwara, Eiji

M-spotty byte error control codes are very effective for correcting/detecting errors in semiconductor memory systems that employ recent high-density RAM chips with wide I/O data (e.g., 8, 16, or 32bits). In this case, the width of the I/O data is one byte. A spotty byte error is defined as random t-bit errors within a byte of length b bits, where 1 le t ≤ b. Then, an error is called an m-spotty byte error if at least one spotty byte error is present in a byte. M-spotty byte error control codes are characterized by the m-spotty distance, which includes the Hamming distance as a special case for t =1 or t = b. The MacWilliams identity provides the relationship between the weight distribution of a code and that of its dual code. The present paper presents the MacWilliams identity for the m-spotty weight enumerator of m-spotty byte error control codes. In addition, the present paper clarifies that the indicated identity includes the MacWilliams identity for the Hamming weight enumerator as a special case.

The memory unsatisfied in Estrella distante of Roberto Bolaño

OpenAIRE

Susana Florinda Ramírez

2015-01-01

This article sets up to examine the fictional strategies appointed  to shape the complexity of the memory processes in there composition of a traumatic experience. Estrella distante (1996), discusses the identity of the subject and, consequently, questions the supposed transparency of testimonies. Critical memory opens the past to uninterrupted interpretations in order to prevent the crystallization of a solesense of facts.

Metal-organic molecular device for non-volatile memory storage

International Nuclear Information System (INIS)

Radha, B.; Sagade, Abhay A.; Kulkarni, G. U.

2014-01-01

Non-volatile memory devices have been of immense research interest for their use in active memory storage in powered off-state of electronic chips. In literature, various molecules and metal compounds have been investigated in this regard. Molecular memory devices are particularly attractive as they offer the ease of storing multiple memory states in a unique way and also represent ubiquitous choice for miniaturized devices. However, molecules are fragile and thus the device breakdown at nominal voltages during repeated cycles hinders their practical applicability. Here, in this report, a synergetic combination of an organic molecule and an inorganic metal, i.e., a metal-organic complex, namely, palladium hexadecylthiolate is investigated for memory device characteristics. Palladium hexadecylthiolate following partial thermolysis is converted to a molecular nanocomposite of Pd(II), Pd(0), and long chain hydrocarbons, which is shown to exhibit non-volatile memory characteristics with exceptional stability and retention. The devices are all solution-processed and the memory action stems from filament formation across the pre-formed cracks in the nanocomposite film.

A narrative approach to understand students’ identities and choices

DEFF Research Database (Denmark)

Holmegaard, Henriette Tolstrup; Ulriksen, Lars; Madsen, Lene Møller

2015-01-01

This chapter demonstrates how narrative theory in general, and narrative psychology in particular, contribute to understand how students make meaning of their choice of post-secondary studies. In particular two central ideas within the theory are unfolded; the concept of identity and the concept...... of time. The applicability of the theory is discussed using empirical examples. The chapter argues that a narrative approach provides an understanding of choice of study as continuous processes where individuals work on their identities in terms of negotiating and constructing a coherent choice...... of the chapter consequences for future research are discussed as well as how this approach to students’ choices of study contributes to our understanding of students’ science, technology, engineering and mathematics (STEM) choices....

Self-defining future projections: exploring the identity function of thinking about the future.

Science.gov (United States)

D'Argembeau, Arnaud; Lardi, Claudia; Van der Linden, Martial

2012-01-01

The act of projecting oneself into meaningful future events may significantly contribute to a person's sense of self and identity. Yet if the role of memories, in particular self-defining memories (SDMs), in grounding the self is now well established, the identity function of anticipated future events has received comparatively little attention. This article introduces the construct of self-defining future projection (SDFP) to address this issue. Two studies show that people can readily identify significant future events that they frequently think about and that convey core information about who they are as individuals. Furthermore, a person's particular style of constructing SDMs is similarly manifested in SDFPs, suggesting that both types of events can be used to ground the self. Notably, people who display a stronger tendency to extract meaning from their past experiences also reflect more about the potential implications of imagined future events. The results further demonstrate that SDMs and SDFPs both give rise to a strong sense of personal continuity over time and are meaningfully related to self-esteem. Together these findings lend support to the idea that a person's sense of self and identity is in part nourished by the anticipation of significant future events.

Infants use temporal regularities to chunk objects in memory.

Science.gov (United States)

Kibbe, Melissa M; Feigenson, Lisa

2016-01-01

Infants, like adults, can maintain only a few items in working memory, but can overcome this limit by creating more efficient representations, or "chunks." Previous research shows that infants can form chunks using shared features or spatial proximity between objects. Here we asked whether infants also can create chunked representations using regularities that unfold over time. Thirteen-month old infants first were familiarized with four objects of different shapes and colors, presented in successive pairs. For some infants, the identities of objects in each pair varied randomly across familiarization (Experiment 1). For others, the objects within a pair always co-occurred, either in consistent relative spatial positions (Experiment 2a) or varying spatial positions (Experiment 2b). Following familiarization, infants saw all four objects hidden behind a screen and then saw the screen lifted to reveal either four objects or only three. Infants in Experiment 1, who had been familiarized with random object pairings, failed to look longer at the unexpected 3-object outcome; they showed the same inability to concurrently represent four objects as in other studies of infant working memory. In contrast, infants in Experiments 2a and 2b, who had been familiarized with regularly co-occurring pairs, looked longer at the unexpected outcome. These infants apparently used the co-occurrence between individual objects during familiarization to form chunked representations that were later deployed to track the objects as they were hidden at test. In Experiment 3, we confirmed that the familiarization affected infants' ability to remember the occluded objects rather than merely establishing longer-term memory for object pairs. Following familiarization to consistent pairs, infants who were not shown a hiding event (but merely saw the same test outcomes as in Experiments 2a and b) showed no preference for arrays of three versus four objects. Finally, in Experiments 4 and 5, we asked

Donor-specific Anti-HLA antibodies in allogeneic hematopoietic stem cell transplantation

Directory of Open Access Journals (Sweden)

Sarah Morin-Zorman

2016-08-01

Full Text Available Allogeneic Hematopoietic Stem Cell Transplantation (AHSCT is a curative treatment for a wide variety of hematological diseases. In 30% of the cases, a geno-identical donor is available. Any other situation displays some level of Human Leukocyte Antigen (HLA incompatibility between donor and recipient. Deleterious effects of anti-HLA immunization have long been recognized in solid organ transplant recipients. More recently, anti-HLA immunization was shown to increase the risk of Primary Graft Failure (PGF, a severe complication of AHSCT that occurs in 3 to 4% of matched unrelated donor transplantation and up to 15% in cord blood transplantation and T-cell depleted haplo-identical stem cell transplantation. Rates of PGF in patients with DSA were reported to be between 24 to 83% with the highest rates in haplo-identical and cord blood transplantation recipients. This led to the recommendation of anti-HLA antibody screening to detect Donor Specific Antibodies (DSA in recipients prior to AHSCT. In this review, we highlight the role of anti-HLA antibodies in AHSCT and the mechanisms that may lead to PGF in patients with DSA, and discuss current issues in the field.

Hard Identity and Soft Identity

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Hassan Rachik

2006-04-01

Full Text Available Often collective identities are classified depending on their contents and rarely depending on their forms. Differentiation between soft identity and hard identity is applied to diverse collective identities: religious, political, national, tribal ones, etc. This classification is made following the principal dimensions of collective identities: type of classification (univocal and exclusive or relative and contextual, the absence or presence of conflictsof loyalty, selective or totalitarian, objective or subjective conception, among others. The different characteristics analysed contribute to outlining an increasingly frequent type of identity: the authoritarian identity.

Voluntary eyeblinks disrupt iconic memory.

Science.gov (United States)

Thomas, Laura E; Irwin, David E

2006-04-01

In the present research, we investigated whether eyeblinks interfere with cognitive processing. In Experiment 1, the participants performed a partial-report iconic memory task in which a letter array was presented for 106 msec, followed 50, 150, or 750 msec later by a tone that cued recall of onerow of the array. At a cue delay of 50 msec between array offset and cue onset, letter report accuracy was lower when the participants blinked following array presentation than under no-blink conditions; the participants made more mislocation errors under blink conditions. This result suggests that blinking interferes with the binding of object identity and object position in iconic memory. Experiment 2 demonstrated that interference due to blinks was not due merely to changes in light intensity. Experiments 3 and 4 demonstrated that other motor responses did not interfere with iconic memory. We propose a new phenomenon, cognitive blink suppression, in which blinking inhibits cognitive processing. This phenomenon may be due to neural interference. Blinks reduce activation in area V1, which may interfere with the representation of information in iconic memory.

War, memories and Little Waterfall; a Syrian village that is no more

DEFF Research Database (Denmark)

Wessels, Josepha Ivanka

2015-01-01

states have pledged to resettle a further 33,000 Syrians. Between 1999 and 2004, the author has conducted long-term anthropological fieldwork in a village called “Little Waterfall” at the edge of the Syrian desert in Aleppo province. In 2014, she travelled back to Aleppo to reconnect with her key......This paper describes the impact of the Syrian war through accounts of conflict, social memories and reconstructed village identities. It looks at the question how memories of home and place are transformed by conflictual mobilities. Since the outbreak of civil war in Syria in March 2011, nine...... and deserted during the Syrian war. This paper reflects on trans-nationalism, social memories and village identities that are influenced by conflictual mobilities. Based on data and video footage collected between 1999 and 2004, complemented by recent filming and interviews with the community members of Little...

Implicit and Explicit Memory Bias in Opiate Dependent, Abstinent and Normal Individuals

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Jafar Hasani

2013-07-01

Full Text Available Objective: The aim of current research was to assess implicit and explicit memory bias to drug related stimuli in opiate Dependent, abstinent and normal Individuals. Method: Three groups including opiate Dependent, abstinent and normal Individuals (n=25 were selected by available sampling method. After matching on the base of age, education level and type of substance use all participants assessed by recognition task (explicit memory bias and stem completion task (implicit memory bias. Results: The analysis of data showed that opiate dependent and abstinent groups in comparison with normal individual had implicit memory bias, whereas in explicit memory only opiate dependent individuals showed bias. Conclusion: The identification of explicit and implicit memory governing addiction may have practical implications in diagnosis, treatment and prevention of substance abuse.

COMPARISON OF THREE DISTINCT PROPHYLACTIC AGENTS AGAINST INVASIVE FUNGAL INFECTIONS IN PATIENTS UNDERGOING HAPLO-IDENTICAL HEMATOPOIETIC STEM CELL TRANSPLANTATION AND POST-TRANSPLANT CYCLOPHOSPHAMIDE

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Jean Elcheikh

2015-08-01

Full Text Available Over the past decade, invasive fungal infections (IFI have remained an important problem in patients undergoing allogeneic haematopoietic stem cell transplantation (Allo-HSCT. The optimal approach for prophylactic antifungal therapy has yet to be determined. We conducted a retrospective, bi-institutional comparative clinical study, and compared the efficacy and safety of micafungin 50mg/day (iv with those of fluconazole (400mg/day or itraconazole 200mg/day (iv as prophylaxis for adult patients with various haematological diseases receiving haplo-identical allogeneic stem cell transplantation (haplo. Overall, 99 patients were identified; 30 patients received micafungin, and 69 patients received fluconazole or itraconazole. After a median follow-up of 13 months (range: 5-23, Proven or probable IFIs were reported in 3 patients (10% in the micafungin group and 8 patients (12% in the fluconazole or itraconazole group. Fewer patients in the micafungin group had invasive aspergillosis (1 [3%] vs. 5 [7%], P=0.6. A total of 4 (13% patients in the micafungin group and 23 (33% patients in the fluconazole or itraconazole group received empirical antifungal therapy (P = 0.14. No serious adverse events related to treatment were reported by patients and there was no treatment discontinuation because of drug-related adverse events in both groups. Despite the retrospective design of the study and limited sample, it contributes reassuring data to confirm results from randomised clinical trials, and to define a place for micafungin in prophylaxis after haplo.

Primary mesenchymal stem cells in human transplanted lungs are CD90/CD105 perivascularly located tissue-resident cells

DEFF Research Database (Denmark)

Rolandsson, Sara; Andersson Sjöland, Annika; Brune, Jan C

2014-01-01

BACKGROUND: Mesenchymal stem cells (MSC) have not only been implicated in the development of lung diseases, but they have also been proposed as a future cell-based therapy for lung diseases. However, the cellular identity of the primary MSC in human lung tissues has not yet been reported. This st......BACKGROUND: Mesenchymal stem cells (MSC) have not only been implicated in the development of lung diseases, but they have also been proposed as a future cell-based therapy for lung diseases. However, the cellular identity of the primary MSC in human lung tissues has not yet been reported...

Publishing SNP genotypes of human embryonic stem cell lines: policy statement of the International Stem Cell Forum Ethics Working Party.

Science.gov (United States)

Knoppers, Bartha M; Isasi, Rosario; Benvenisty, Nissim; Kim, Ock-Joo; Lomax, Geoffrey; Morris, Clive; Murray, Thomas H; Lee, Eng Hin; Perry, Margery; Richardson, Genevra; Sipp, Douglas; Tanner, Klaus; Wahlström, Jan; de Wert, Guido; Zeng, Fanyi

2011-09-01

Novel methods and associated tools permitting individual identification in publicly accessible SNP databases have become a debatable issue. There is growing concern that current technical and ethical safeguards to protect the identities of donors could be insufficient. In the context of human embryonic stem cell research, there are no studies focusing on the probability that an hESC line donor could be identified by analyzing published SNP profiles and associated genotypic and phenotypic information. We present the International Stem Cell Forum (ISCF) Ethics Working Party's Policy Statement on "Publishing SNP Genotypes of Human Embryonic Stem Cell Lines (hESC)". The Statement prospectively addresses issues surrounding the publication of genotypic data and associated annotations of hESC lines in open access databases. It proposes a balanced approach between the goals of open science and data sharing with the respect for fundamental bioethical principles (autonomy, privacy, beneficence, justice and research merit and integrity).

Pro-apoptotic protein Noxa regulates memory T cell population size and protects against lethal immunopathology

NARCIS (Netherlands)

Wensveen, Felix M.; Klarenbeek, Paul L.; van Gisbergen, Klaas P. J. M.; Pascutti, Maria F.; Derks, Ingrid A. M.; van Schaik, Barbera D. C.; ten Brinke, Anja; de Vries, Niek; Cekinovic, Durdica; Jonjic, Stipan; van Lier, René A. W.; Eldering, Eric

2013-01-01

Memory T cells form a highly specific defense layer against reinfection with previously encountered pathogens. In addition, memory T cells provide protection against pathogens that are similar, but not identical to the original infectious agent. This is because each T cell response harbors multiple

Autobiographical memory compromise in Alzheimer's disease: a cognitive and clinical overview.

Science.gov (United States)

El Haj, Mohamad; Roche, Jean; Gallouj, Karim; Gandolphe, Marie-Charlotte

2017-12-01

Autobiographical memory refers to memory for personal information. The compromise of autobiographical memory in Alzheimer's disease (AD) results in a loss of knowledge about events and facts that defined the patients' life, and consequently, degradation of their self-knowledge and sense of identity. The compromise of autobiographical memory in AD can be attributed to a diminished subjective experience of memory and a diminished sense of the self. Our review provides a comprehensive overview of cognitive and clinical processes that may be involved in difficulties to retrieve autobiographical memories in Alzheimer's disease. Our review also proposes a theoretical model according to which, the diminished ability to retrieve contextual information and the overgenerality of recall result in a diminished subjective experience of past and future thinking. Besides its theoretical contribution, our review proposes clinical applicability for evaluation and rehabilitation of autobiographical memory in AD.

Small Change Makes a Big Splash: The Role of Working Self-Concept in the Effects of Stereotype Threat on Memory.

Science.gov (United States)

Liu, Pei; Zhao, Fengqing; Zhang, Baoshan; Dang, Qingxiu

2017-10-03

Assuming that the principle of an active-self account holds true in real life, priming certain constructs could selectively activate a working self-concept, which in turn guides behavior. The current study involved two experiments that examined the relationships between stereotypic identity, working self-concept, and memory performance in older adults. Specifically, Study 1 tested whether a stereotype threat can affect older adults' working self-concept and memory performance. A modified Stroop color naming task and a separate recognition task showed that a stereotype threat prime altered the activation of the working self-concept and deteriorated the older adults' memory performance. Additionally, the working self-concept mediated the effect of stereotype threat on memory performance. Accordingly, we designed Study 2 to assess whether priming different identities can alter the working self-concept of the elderly and buffer the stereotype threat effect on memory performance. The results not only were the same as Study 1 but also revealed that activating multiple identities could mitigate the stereotype threat. These results support an active-self account and the efficacy of stereotype threat intervention. This intervention strategy may be able to be used in real situations to help the elderly alleviate stereotype threats and memory impairment.

Analysis of Memory Formation during General Anesthesia (Propofol/Remifentanil) for Elective Surgery Using the Process-dissociation Procedure.

Science.gov (United States)

Hadzidiakos, Daniel; Horn, Nadja; Degener, Roland; Buchner, Axel; Rehberg, Benno

2009-08-01

There have been reports of memory formation during general anesthesia. The process-dissociation procedure has been used to determine if these are controlled (explicit/conscious) or automatic (implicit/unconscious) memories. This study used the process-dissociation procedure with the original measurement model and one which corrected for guessing to determine if more accurate results were obtained in this setting. A total of 160 patients scheduled for elective surgery were enrolled. Memory for words presented during propofol and remifentanil general anesthesia was tested postoperatively by using a word-stem completion task in a process-dissociation procedure. To assign possible memory effects to different levels of anesthetic depth, the authors measured depth of anesthesia using the BIS XP monitor (Aspect Medical Systems, Norwood, MA). Word-stem completion performance showed no evidence of memory for intraoperatively presented words. Nevertheless, an evaluation of these data using the original measurement model for process-dissociation data suggested an evidence of controlled (C = 0.05; 95% confidence interval [CI] 0.02-0.08) and automatic (A = 0.11; 95% CI 0.09-0.12) memory processes (P memory processes was obtained. The authors report and discuss parallel findings for published data sets that were generated by using the process-dissociation procedure. Patients had no memories for auditory information presented during propofol/remifentanil anesthesia after midazolam premedication. The use of the process-dissociation procedure with the original measurement model erroneously detected memories, whereas the extended model, corrected for guessing, correctly revealed no memory.

The memory unsatisfied in Estrella distante of Roberto Bolaño

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Susana Florinda Ramírez

2015-09-01

Full Text Available This article sets up to examine the fictional strategies appointed  to shape the complexity of the memory processes in there composition of a traumatic experience. Estrella distante (1996, discusses the identity of the subject and, consequently, questions the supposed transparency of testimonies. Critical memory opens the past to uninterrupted interpretations in order to prevent the crystallization of a solesense of facts.

Memory and regional identity in Udihara’s cinema Memória e identidade regional no cinema de Udihara

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Caio Júlio Cesaro

2007-01-01

Full Text Available The cinema produced by the Japanese immigrant Hikoma Udihara, for over 30 years, is a record of the first decades of colonization in Northern of Paraná. The content – a little more than 10 hours of images – constitutes essence of the memory and identity in the region. A file which, in spite of private and institutional efforts for its maintenance, is vanishing and deteriorating quickly. For this reason, urgent action is required for recuperation and preservation. O cinema produzido pelo imigrante japonês Hikoma Udihara, ao longo de mais de 30 anos, documenta as primeiras décadas da colonização do Norte do Paraná. O conteúdo – de pouco mais de dez horas de imagens – constitui-se essência da memória e da identidade da região. Um acervo que, apesar de esforços particulares e institucionais para sua manutenção, está esvaecendo e se desintegrando rapidamente. Em razão disso, necessita de ações urgentes de recuperação e preservação.

Siberian Regional Identity in the Context of Historical Consciousness (Content Analysis of Tomsk Regional Media

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A V Bocharov

2011-12-01

Full Text Available The article presents a model to study the Siberian regional identity in the context of historical consciousness, as well as the results of its practical application in the content analysis of the publications by the Tomsk regional media. On the basis of the content analysis procedures the author demonstrates how, through historical memory, the regional identity is formed and manifested in the regional media in various spheres of society.

Object recognition memory in zebrafish.

Science.gov (United States)

May, Zacnicte; Morrill, Adam; Holcombe, Adam; Johnston, Travis; Gallup, Joshua; Fouad, Karim; Schalomon, Melike; Hamilton, Trevor James

2016-01-01

The novel object recognition, or novel-object preference (NOP) test is employed to assess recognition memory in a variety of organisms. The subject is exposed to two identical objects, then after a delay, it is placed back in the original environment containing one of the original objects and a novel object. If the subject spends more time exploring one object, this can be interpreted as memory retention. To date, this test has not been fully explored in zebrafish (Danio rerio). Zebrafish possess recognition memory for simple 2- and 3-dimensional geometrical shapes, yet it is unknown if this translates to complex 3-dimensional objects. In this study we evaluated recognition memory in zebrafish using complex objects of different sizes. Contrary to rodents, zebrafish preferentially explored familiar over novel objects. Familiarity preference disappeared after delays of 5 mins. Leopard danios, another strain of D. rerio, also preferred the familiar object after a 1 min delay. Object preference could be re-established in zebra danios by administration of nicotine tartrate salt (50mg/L) prior to stimuli presentation, suggesting a memory-enhancing effect of nicotine. Additionally, exploration biases were present only when the objects were of intermediate size (2 × 5 cm). Our results demonstrate zebra and leopard danios have recognition memory, and that low nicotine doses can improve this memory type in zebra danios. However, exploration biases, from which memory is inferred, depend on object size. These findings suggest zebrafish ecology might influence object preference, as zebrafish neophobia could reflect natural anti-predatory behaviour. Copyright © 2015 Elsevier B.V. All rights reserved.

The mysteries of remote memory

Science.gov (United States)

2018-01-01

Long-lasting memories form the basis of our identity as individuals and lie central in shaping future behaviours that guide survival. Surprisingly, however, our current knowledge of how such memories are stored in the brain and retrieved, as well as the dynamics of the circuits involved, remains scarce despite seminal technical and experimental breakthroughs in recent years. Traditionally, it has been proposed that, over time, information initially learnt in the hippocampus is stored in distributed cortical networks. This process—the standard theory of memory consolidation—would stabilize the newly encoded information into a lasting memory, become independent of the hippocampus, and remain essentially unmodifiable throughout the lifetime of the individual. In recent years, several pieces of evidence have started to challenge this view and indicate that long-lasting memories might already ab ovo be encoded, and subsequently stored in distributed cortical networks, akin to the multiple trace theory of memory consolidation. In this review, we summarize these recent findings and attempt to identify the biologically plausible mechanisms based on which a contextual memory becomes remote by integrating different levels of analysis: from neural circuits to cell ensembles across synaptic remodelling and epigenetic modifications. From these studies, remote memory formation and maintenance appear to occur through a multi-trace, dynamic and integrative cellular process ranging from the synapse to the nucleus, and represent an exciting field of research primed to change quickly as new experimental evidence emerges. This article is part of a discussion meeting issue ‘Of mice and mental health: facilitating dialogue between basic and clinical neuroscientists’. PMID:29352028

Motivation for Weight Loss affects recall from Autobiographical Memory in Dieters

DEFF Research Database (Denmark)

Johannessen, Kim Berg; Berntsen, Dorthe

2008-01-01

Two studies examined the connection between motivation and autobiographical memories. We expected memories recalled in response to dieting-related cue words to be more central to the person's identity and life story and to contain more body and weight related elements for dieters than for non......-dieters. We expected no differences on memories recalled in response to neutral cue words. Study 1: 29 normal/overweight dieters and 48 non-dieters participated. Study 2: 18 obese dieters and 19 non-dieters participated. We conducted repeated measures tests. The hypotheses were supported, which support...

Can mammalian cloning combined with embryonic stem cell technologies be used to treat human diseases?

Science.gov (United States)

Hadjantonakis, Anna-Katerina; Papaioannou, Virginia E

2002-01-01

Cloning is commonly perceived as a means of generating genetically identical individuals, but it can also be used to obtain genetically matched embryo-derived stem cells, which could potentially be used in the treatment of patients. A recent report offers the first 'proof of principle' of such cloning for therapeutic purposes, referred to as nuclear transplantation to produce stem cells for autologous transplantation. PMID:12186652

Increasing Stem Cell Dose Promotes Posttransplant Immune Reconstitution.

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Xu, Ning; Shen, Sylvie; Dolnikov, Alla

2017-04-01

Umbilical cord blood (UCB) transplantation can provide a successful therapeutic option for patients that have no suitable related donor. UCB transplantation is often limited by the relatively small hematopoietic stem cell (HSC) numbers in UCB especially for adult recipients. Early neutrophil and platelet engraftment correlates with the stem cell numbers in UCB transplant. Compared to other HSC sources, immune reconstitution following UCB transplant is slower and complicated by increased frequency of opportunistic infections. The effect of HSC numbers in UCB transplant on immune reconstitution was not thoroughly examined. Using immunocompromised mice transplanted with purified UCB CD34+ stem cells, we have demonstrated that increasing the numbers of CD34+ cells in the transplant promotes hematopoietic and immune reconstitution. At early stages posttransplant, high stem cell dose generated relatively more B cells, while lower dose generated more myeloid and T cells. Thus, the size of the stem cell graft appears to modulate the differentiation potential of infused stem cells. In addition, increasing stem cell dose in the transplant improved CD8+ T cell development and delayed late memory T cell skewing in expense of naive T cells highlighting the importance of HSC dose to maintain the pool of naive T cells able to develop strong immune responses. Transplantation of ex vivo expanded CD34+ cells did not promote, but rather delayed immune reconstitution suggesting the loss of primitive lymphoid precursor cells during ex vivo expansion.

The Gorani Wedding Ritual – Between Individual and Collective Memory

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Jadranka Đorđević Crnobrnja

2014-11-01

Full Text Available In this paper I will attempt to determine which contents are present in individual memories of weddings and underline the contents which contribute to the formation of commonplace memories within personal memories. By studying individual personal memories of a ritual practice, I will attempt to answer questions about the relationship between individual and collective memory. In the paper I will also consider the issue of the influence of individual memories on the construction of ethnic identity. The paper is based on an analysis of narrative discourse which has been adapted for ethnographic research. The Gorani wedding ritual represents a social practice which encompasses not only the influence of collective on personal remembrance and memory, but also the reverse. The Gorani wedding ritual is an example of a social holiday which, on a personal level creates a feeling of connection between individuals and their community, while on a collective level it creates conditions for the continuity of the Gorani community.

Autobiographical memory in Parkinson's disease: a retrieval deficit.

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Souchay, Celine; Smith, Sarah Jane

2013-09-01

This study examined the effects of providing cues to facilitate autobiographical memory retrieval in Parkinson's disease. Previous findings have shown that individuals with Parkinson's disease retrieve fewer specific autobiographical memories than older adult controls. These findings are clinically significant since the quality of autobiographical memory is linked to identity and sense of self. In the current study, 16 older adults with Parkinson's disease without dementia and 16 matched older adult controls were given 3 min in which to recall autobiographical memories associated with five different time periods and to give each memory a short title. Participants were later asked to retrieve the memories in three phases: firstly in a free recall phase; secondly in response to general cues (time periods) and finally in response to specific cues (the short titles previously given). The number of memories and the quality of the memory (general or specific) was recorded in each condition. Compared with matched older adult controls, the Parkinson's disease group was impaired in retrieving the memories that they had previously given in the free recall phase and in response to general cues. The performance of the group with Parkinson's disease was only equivalent to the older adults when they retrieved memories in response to self-generated cues. The findings are discussed in relation to theories of autobiographical memory and the neuropsychology of Parkinson's disease. © 2013 The British Psychological Society.

A Cultural Psychological Analysis of Collective Memory as Mediated Action: Constructions of Indian History

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Sahana Mukherjee

2018-01-01

Full Text Available The present research applies a cultural psychological perspective on collective memory as mediated action to examine how constructions of a national past serve as tools that both reflect and shape national identity concerns. We employ a situation-sampling method to investigate collective memory in a series of studies concerning intergroup relations in the Indian context. In Study 1, participants (N = 55 generated three historical events that they considered important/relevant for Indian history. In Study 2, participants (N = 95 rated the importance and relevance of these events in a within-participant design. Illuminating the psychological constitution of cultural reality, frequency of recall (Study 1 and ratings of importance/relevance (Study 2 were greater for nation-glorifying events celebrating ingroup triumph than for typically silenced, critical events acknowledging ingroup wrongdoing. Moreover, these patterns were stronger among participants who scored higher in national identification. In Studies 3 (N = 65 and 4 (N = 160, we exposed participants to different categories of events in a between-participants design. Illuminating the cultural constitution of psychological experience, participants exposed to typically silenced, critical events reported lower national identification and greater perception of injustice against marginalized groups than did participants exposed to nation-glorifying events. Together, results illuminate a conception of collective memory as mediated action. Producers invest memory products with an identity-interested charge that directs subsequent intergroup relations toward identity-consistent ends.

Neural correlates of enhanced visual short-term memory for angry faces: an FMRI study.

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Margaret C Jackson

Full Text Available Fluid and effective social communication requires that both face identity and emotional expression information are encoded and maintained in visual short-term memory (VSTM to enable a coherent, ongoing picture of the world and its players. This appears to be of particular evolutionary importance when confronted with potentially threatening displays of emotion - previous research has shown better VSTM for angry versus happy or neutral face identities.Using functional magnetic resonance imaging, here we investigated the neural correlates of this angry face benefit in VSTM. Participants were shown between one and four to-be-remembered angry, happy, or neutral faces, and after a short retention delay they stated whether a single probe face had been present or not in the previous display. All faces in any one display expressed the same emotion, and the task required memory for face identity. We find enhanced VSTM for angry face identities and describe the right hemisphere brain network underpinning this effect, which involves the globus pallidus, superior temporal sulcus, and frontal lobe. Increased activity in the globus pallidus was significantly correlated with the angry benefit in VSTM. Areas modulated by emotion were distinct from those modulated by memory load.Our results provide evidence for a key role of the basal ganglia as an interface between emotion and cognition, supported by a frontal, temporal, and occipital network.

The Executive Control of Face Memory

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Steven Z. Rapcsak

2011-01-01

Full Text Available Patients with frontal lobe damage and cognitively normal elderly individuals demonstrate increased susceptibility to false facial recognition. In this paper we review neuropsychological evidence consistent with the notion that the common functional impairment underlying face memory distortions in both subject populations is a context recollection/source monitoring deficit, coupled with excessive reliance on relatively preserved facial familiarity signals in recognition decisions. In particular, we suggest that due to the breakdown of strategic memory retrieval, monitoring, and decision operations, individuals with frontal lobe impairment caused by focal damage or age-related functional decline do not have a reliable mechanism for attributing the experience of familiarity to the correct context or source. Memory illusions are mostly apparent under conditions of uncertainty when the face cue does not directly elicit relevant identity-specific contextual information, leaving the source of familiarity unspecified or ambiguous. Based on these findings, we propose that remembering faces is a constructive process that requires dynamic interactions between temporal lobe memory systems that operate in an automatic or bottom-up fashion and frontal executive systems that provide strategic top-down control of recollection. Executive memory control functions implemented by prefrontal cortex play a critical role in suppressing false facial recognition and related source memory misattributions.

Improvement of spatial memory of male parkinsonian rats after treatment with adipose stem cells and rosemary leaf extract

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Mahdieh Ramezanihossienabadi

2018-01-01

Full Text Available Background: Due to the neuroprotective effect of rosemary extract, this study aimed at examining the effect of co-treatment of adipose stem cells transplantation and the extract on memory disability of parkinsonian rats. Materials and Methods: In this experimental study, male parkinsonian rats were prepared by bilateral injection of 6-OHDA. The sham group was injected normal saline into the substantia nigra. The extract+medium group was gavaged with the extract 14 days before until 8 weeks after the injury, and the medium was intravenously injected. The extract+cell group was orally gavaged with the extract and the cells were injected. Morris water maze training was conducted one week before and after the lesion and also a retrieval test was performed 4 and 8 weeks after the lesion. Results: There was no significant difference in distance moved and escape latency at training days, before the injury, between the groups. However, a week after the injury, learning ability in lesioned animals was significantly decreased as compared to the sham group (P<0.05. Results of retention tests in four and eight weeks were similar. Duration of escape latency and time spent in target quadrant of lesioned rats were significantly increased and decreased respectively as compared to the sham (P<0.05. The extract+medium and extract+cell groups showed significant decrease and increase in escape latency and time spent in target quadrant as compared to the lesioned group (P<0.05, respectively. Conclusion: The cell therapy accompanied with orally administration of the rosemary extract can improve memory deficit in Parkinson’s disease.

Immune Curbing of Cancer Stem Cells by CTLs Directed to NANOG

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Christina Wefers

2018-06-01

Full Text Available Cancer stem cells (CSCs have been identified as the source of tumor growth and disease recurrence. Eradication of CSCs is thus essential to achieve durable responses, but CSCs are resistant to current anti-tumor therapies. Novel therapeutic approaches that specifically target CSCs will, therefore, be crucial to improve patient outcome. Immunotherapies, which boost the body’s own immune system to eliminate cancerous cells, could be an alternative approach to target CSCs. Vaccines of dendritic cells (DCs loaded with tumor antigens can evoke highly specific anti-tumor T cell responses. Importantly, DC vaccination also promotes immunological memory formation, paving the way for long-term cancer control. Here, we propose a DC vaccination that specifically targets CSCs. DCs loaded with NANOG peptides, a protein required for maintaining stem cell properties, could evoke a potent anti-tumor immune response against CSCs. We hypothesize that the resulting immunological memory will also control newly formed CSCs, thereby preventing disease recurrence.

Being Riveted to Oneself: Shame and Personal Identity

OpenAIRE

Montes Sánchez, Alba

2011-01-01

II Workshop on Identity, Memory and Experience. Getafe (Spain), March 1-4th, 2011 In Shame and Necessity, his brilliant book on the ethics of the Ancient Greeks, Bernard Williams performed a detailed and intriguing analysis of an emotion that, up to then, had been given little merit in connection to morality. Arguing with his former professor, E.R. Dodds, and picking up on a distinction between "shame cultures" and "guilt cultures" drawn by American anthropologist Ruth Benedict, William...

Review Essay: "To Go to the Body." Advances in Phenomenological-sociological Identity Theory

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Thorsten Berndt

2003-09-01

Full Text Available Starting with a critique of conventional research on identity, which neglects the body as a fundamental entity of identity, GUGUTZER develops a theoretical framework from the works of PLESSNER, MERLEAU-PONTY, SCHMITZ and BOURDIEU. From this framework GUGUTZER has carried out an empirical study on the relationship between identity on the one hand, and "to have a body" ("Körper"/ "being a body" ("Leib" on the other, which is PLESSNER's basic differentiation. The study employs the methodology of Grounded Theory. Interviews were conducted with ballet dancers, monks and nuns, grounded and supplemented with observations. The results bring the complex of "being a body" ("Leib" and bodily sensation into a central relationship to identity, in which the use of the body is seen under the aspect of self-evaluation, memory, control and borderline situations. GUGUTZER's book is an important contribution to the phenomenological-sociological theory of identity. URN: urn:nbn:de:0114-fqs0303101

Antimosquito Phenylpropenoids from the Stem and Root Barks of ...

African Journals Online (AJOL)

Michael Horsfall

The plant species was identified on site and its identity was further confirmed at the Herbarium of the. Department of Botany, University of Dar es Salaam, where a voucher specimen is deposited. Extraction and Isolation: The air dried and pulverized root and stem barks were extracted sequentially with CHCl3 and MeOH, 2 x ...

Short-term memory across eye blinks.

Science.gov (United States)

Irwin, David E

2014-01-01

The effect of eye blinks on short-term memory was examined in two experiments. On each trial, participants viewed an initial display of coloured, oriented lines, then after a retention interval they viewed a test display that was either identical or different by one feature. Participants kept their eyes open throughout the retention interval on some blocks of trials, whereas on others they made a single eye blink. Accuracy was measured as a function of the number of items in the display to determine the capacity of short-term memory on blink and no-blink trials. In separate blocks of trials participants were instructed to remember colour only, orientation only, or both colour and orientation. Eye blinks reduced short-term memory capacity by approximately 0.6-0.8 items for both feature and conjunction stimuli. A third, control, experiment showed that a button press during the retention interval had no effect on short-term memory capacity, indicating that the effect of an eye blink was not due to general motoric dual-task interference. Eye blinks might instead reduce short-term memory capacity by interfering with attention-based rehearsal processes.

Autologous Stem Cell Transplantation Disrupts Adaptive Immune Responses during Rebound Simian/Human Immunodeficiency Virus Viremia.

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Reeves, Daniel B; Peterson, Christopher W; Kiem, Hans-Peter; Schiffer, Joshua T

2017-07-01

Primary HIV-1 infection induces a virus-specific adaptive/cytolytic immune response that impacts the plasma viral load set point and the rate of progression to AIDS. Combination antiretroviral therapy (cART) suppresses plasma viremia to undetectable levels that rebound upon cART treatment interruption. Following cART withdrawal, the memory component of the virus-specific adaptive immune response may improve viral control compared to primary infection. Here, using primary infection and treatment interruption data from macaques infected with simian/human immunodeficiency virus (SHIV), we observe a lower peak viral load but an unchanged viral set point during viral rebound. The addition of an autologous stem cell transplant before cART withdrawal alters viral dynamics: we found a higher rebound set point but similar peak viral loads compared to the primary infection. Mathematical modeling of the data that accounts for fundamental immune parameters achieves excellent fit to heterogeneous viral loads. Analysis of model output suggests that the rapid memory immune response following treatment interruption does not ultimately lead to better viral containment. Transplantation decreases the durability of the adaptive immune response following cART withdrawal and viral rebound. Our model's results highlight the impact of the endogenous adaptive immune response during primary SHIV infection. Moreover, because we capture adaptive immune memory and the impact of transplantation, this model will provide insight into further studies of cure strategies inspired by the Berlin patient. IMPORTANCE HIV patients who interrupt combination antiretroviral therapy (cART) eventually experience viral rebound, the return of viral loads to pretreatment levels. However, the "Berlin patient" remained free of HIV rebound over a decade after stopping cART. His cure is attributed to leukemia treatment that included an HIV-resistant stem cell transplant. Inspired by this case, we studied the impact

Memory Interventions in the Criminal Justice System: Some Practical Ethical Considerations.

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Cabrera, Laura Y; Elger, Bernice S

2016-03-01

In recent years, discussion around memory modification interventions has gained attention. However, discussion around the use of memory interventions in the criminal justice system has been mostly absent. In this paper we start by highlighting the importance memory has for human well-being and personal identity, as well as its role within the criminal forensic setting; in particular, for claiming and accepting legal responsibility, for moral learning, and for retribution. We provide examples of memory interventions that are currently available for medical purposes, but that in the future could be used in the forensic setting to modify criminal offenders' memories. In this section we contrast the cases of (1) dampening and (2) enhancing memories of criminal offenders. We then present from a pragmatic approach some pressing ethical issues associated with these types of memory interventions. The paper ends up highlighting how these pragmatic considerations can help establish ethically justified criteria regarding the possibility of interventions aimed at modifying criminal offenders' memories.

Auditory memory for temporal characteristics of sound.

Science.gov (United States)

Zokoll, Melanie A; Klump, Georg M; Langemann, Ulrike

2008-05-01

This study evaluates auditory memory for variations in the rate of sinusoidal amplitude modulation (SAM) of noise bursts in the European starling (Sturnus vulgaris). To estimate the extent of the starling's auditory short-term memory store, a delayed non-matching-to-sample paradigm was applied. The birds were trained to discriminate between a series of identical "sample stimuli" and a single "test stimulus". The birds classified SAM rates of sample and test stimuli as being either the same or different. Memory performance of the birds was measured as the percentage of correct classifications. Auditory memory persistence time was estimated as a function of the delay between sample and test stimuli. Memory performance was significantly affected by the delay between sample and test and by the number of sample stimuli presented before the test stimulus, but was not affected by the difference in SAM rate between sample and test stimuli. The individuals' auditory memory persistence times varied between 2 and 13 s. The starlings' auditory memory persistence in the present study for signals varying in the temporal domain was significantly shorter compared to that of a previous study (Zokoll et al. in J Acoust Soc Am 121:2842, 2007) applying tonal stimuli varying in the spectral domain.

Verbal Working Memory Is Related to the Acquisition of Cross-Linguistic Phonological Regularities.

Science.gov (United States)

Bosma, Evelyn; Heeringa, Wilbert; Hoekstra, Eric; Versloot, Arjen; Blom, Elma

2017-01-01

Closely related languages share cross-linguistic phonological regularities, such as Frisian -âld [ͻ:t] and Dutch -oud [ʱut], as in the cognate pairs kâld [kͻ:t] - koud [kʱut] 'cold' and wâld [wͻ:t] - woud [wʱut] 'forest'. Within Bybee's (1995, 2001, 2008, 2010) network model, these regularities are, just like grammatical rules within a language, generalizations that emerge from schemas of phonologically and semantically related words. Previous research has shown that verbal working memory is related to the acquisition of grammar, but not vocabulary. This suggests that verbal working memory supports the acquisition of linguistic regularities. In order to test this hypothesis we investigated whether verbal working memory is also related to the acquisition of cross-linguistic phonological regularities. For three consecutive years, 5- to 8-year-old Frisian-Dutch bilingual children ( n = 120) were tested annually on verbal working memory and a Frisian receptive vocabulary task that comprised four cognate categories: (1) identical cognates, (2) non-identical cognates that either do or (3) do not exhibit a phonological regularity between Frisian and Dutch, and (4) non-cognates. The results showed that verbal working memory had a significantly stronger effect on cognate category (2) than on the other three cognate categories. This suggests that verbal working memory is related to the acquisition of cross-linguistic phonological regularities. More generally, it confirms the hypothesis that verbal working memory plays a role in the acquisition of linguistic regularities.

Marketing the `Broad Line': Invitations to STEM education in a Swedish recruitment campaign

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Andrée, Maria; Hansson, Lena

2013-01-01

In many Western societies, there is a concern about the tendency of young people not choosing Science, Technology, Engineering, and Mathematics (STEM) education and occupations. In response, different initiatives have been launched. If one believes that science should have a place in more young people's lives, an important question is to what extent recruitment campaigns communicate messages that open up for STEM education to become relevant in young people's identity formation. Here, we analyse a Swedish government-initiated, primarily Internet-based recruitment attempt ('The Broad Line Campaign') aimed at increasing the number of young people choosing the natural science programme in upper secondary school. The campaign is based on marketing principles and deliberately draws on identity issues. The data analysed consists of campaign films and written resources describing the campaign. Data are analysed by use of the constant comparative approach in order to produce categories describing different messages about why to engage in STEM education. These messages are then analysed from an identity perspective using the concept of subjective values. Our results show that the messages communicated in the Broad Line campaign emphasise utility value, attainment value and relative cost rather than interest-enjoyment. The campaign communicates that the natural science programme is to be associated with a high attainment value without establishing relations to the field of science. Finally, potential consequences of the communicated messages in the campaign are discussed in light of previous research.

Osobní identita a paměť (Lockova teorie osobní identity a její kritická interpretace v analytické filosofii)

OpenAIRE

Kollmann, Jan

2008-01-01

The thesis deals with the relations between Locke's theory of personal identity, its "classical" critic, performed by Butler and Reid and its critical adoption amongst some authors of analytic philosophy (Grice, Quinton, Perry, Shoemaker). In the first part of the thesis, Locke is shown as the founder of a tradition that lays stress on the fundamental relation between the identity of persons over time and its memory or consciousness. We also distinguish the identity of person and the identity...

On the quantitativeness of EDS STEM

Energy Technology Data Exchange (ETDEWEB)

Lugg, N.R. [Institute of Engineering Innovation, The University of Tokyo, 2-11-16, Yayoi, Bunkyo-ku, Tokyo 113-8656 (Japan); Kothleitner, G. [Institute for Electron Microscopy and Nanoanalysis, Graz University of Technology, Steyrergasse 17, 8010 Graz (Austria); Centre for Electron Microscopy, Steyrergasse 17, 8010 Graz (Austria); Shibata, N.; Ikuhara, Y. [Institute of Engineering Innovation, The University of Tokyo, 2-11-16, Yayoi, Bunkyo-ku, Tokyo 113-8656 (Japan)

2015-04-15

Chemical mapping using energy dispersive X-ray spectroscopy (EDS) in scanning transmission electron microscopy (STEM) has recently shown to be a powerful technique in analyzing the elemental identity and location of atomic columns in materials at atomic resolution. However, most applications of EDS STEM have been used only to qualitatively map whether elements are present at specific sites. Obtaining calibrated EDS STEM maps so that they are on an absolute scale is a difficult task and even if one achieves this, extracting quantitative information about the specimen – such as the number or density of atoms under the probe – adds yet another layer of complexity to the analysis due to the multiple elastic and inelastic scattering of the electron probe. Quantitative information may be obtained by comparing calibrated EDS STEM with theoretical simulations, but in this case a model of the structure must be assumed a priori. Here we first theoretically explore how exactly elastic and thermal scattering of the probe confounds the quantitative information one is able to extract about the specimen from an EDS STEM map. We then show using simulation how tilting the specimen (or incident probe) can reduce the effects of scattering and how it can provide quantitative information about the specimen. We then discuss drawbacks of this method – such as the loss of atomic resolution along the tilt direction – but follow this with a possible remedy: precession averaged EDS STEM mapping. - Highlights: • Signal obtained in EDS STEM maps (of STO) compared to non-channelling signal. • Deviation from non-channelling signal occurs in on-axis experiments. • Tilting specimen: signal close to non-channelling case but atomic resolution is lost. • Tilt-precession series: non-channelling signal and atomic-resolution features obtained. • Associated issues are discussed.

Minoritized Students In STEM Pathways at Community Colleges

Science.gov (United States)

Babcock, Michael Jason

Community colleges are a prominent academic pathway for future scientists, engineers, and mathematicians, and serve as a gateway to higher education for traditionally marginalized student populations. Because of this, community colleges are uniquely positioned to combat the underrepresentation of African American, Latino/a, Native American, and Pacific Islander students in STEM. Research on students of color in STEM, however, has traditionally focused on K-12 schools and four-year colleges and universities, leaving a gap in our understanding about the role of community colleges in shaping student intentions to pursue STEM careers. To address that gap, this study examined students as they pursued a degree in STEM at a community college, for the purposes of contributing to our understandings of students of color in these environments. Utilizing science identity framing and longitudinal multi-case study methods, this study followed thirteen students as they navigated the community college and made decisions regarding their pursuit of a future in STEM fields. Specifically, this study illuminates the racialized nature of STEM at a community college, student thinking around choices to opt into or out of STEM, and the decision-making around choices to persist. Insight into the social and contextual factors underlying students' persistence demonstrates that students of color (especially women of color) do encounter hostile experiences within STEM contexts at community colleges, but how they respond to those hostilities influences persistence. Students who attribute hostilities such as micro-aggressions to the biases of others are more likely to persist. Students who do not attribute those hostilities to others are more likely to assume their experiences are attributable to the fact they do not belong in STEM. The findings establish the importance of recognizing and acknowledging the racialized and gendered nature of STEM, both in academic settings and at home, for those

Outsourcing Memory in Response to an Aging Population.

Science.gov (United States)

Ross, Michael; Schryer, Emily

2015-11-01

With baby boomers entering old age and longevity increasing, policymakers have focused on the physical, social, and health needs of older persons. We urge policymakers to consider cognitive aging as well, particularly normal, age-related memory decline. Psychological scientists attribute memory decline mainly to cognitive overload stemming from age-related reductions in sensory capacities, speed of cognitive processing, and the ability to filter out irrelevant information. Even in the absence of decline, however, memory is imperfect and forgetting can be especially consequential for older adults. For example, forgetting to take prescription medicines is an age-related problem largely because older adults tend to ingest many more prescription drugs. We propose that policymakers focus on increasing environmental support for memory that can reduce the burden on cognitive resources and thus improve recall. In providing environmental support, policymakers need to pay careful attention to potential age-related changes in physical and cognitive capacity, as well as behavior. © The Author(s) 2015.

Effects of stereotypes and suggestion on memory.

Science.gov (United States)

Shechory, Mally; Nachson, Israel; Glicksohn, Joseph

2010-02-01

In this study, the interactive effect of stereotype and suggestion on accuracy of memory was examined by presenting 645 participants (native Israelis and immigrants from the former Soviet Union and Ethiopia) with three versions of a story about a worker who is waiting in a manager's office for a meeting. All versions were identical except for the worker's name, which implied a Russian or an Ethiopian immigrant or a person of no ethnic origin. Each participant was presented with one version of the story. After an hour delay, the participants' memories were tested via two questionnaires that differed in terms of level of suggestion. Data analyses show that (a) when a suggestion matched the participant's stereotypical perception, the suggestion was incorporated into memory but (b) when the suggestion contradicted the stereotype, it did not influence memory. The conclusion was that recall is influenced by stereotypes but can be enhanced by compatible suggestions.

Functional, Antigen-Specific Stem Cell Memory (TSCM CD4+ T Cells Are Induced by Human Mycobacterium tuberculosis Infection

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Cheleka A. M. Mpande

2018-03-01

Full Text Available BackgroundMaintenance of long-lasting immunity is thought to depend on stem cell memory T cells (TSCM, which have superior self-renewing capacity, longevity and proliferative potential compared with central memory (TCM or effector (TEFF T cells. Our knowledge of TSCM derives primarily from studies of virus-specific CD8+ TSCM. We aimed to determine if infection with Mycobacterium tuberculosis (M. tb, the etiological agent of tuberculosis, generates antigen-specific CD4+ TSCM and to characterize their functional ontology.MethodsWe studied T cell responses to natural M. tb infection in a longitudinal adolescent cohort of recent QuantiFERON-TB Gold (QFT converters and three cross-sectional QFT+ adult cohorts; and to bacillus Calmette–Guerin (BCG vaccination in infants. M. tb and/or BCG-specific CD4 T cells were detected by flow cytometry using major histocompatibility complex class II tetramers bearing Ag85, CFP-10, or ESAT-6 peptides, or by intracellular cytokine staining. Transcriptomic analyses of M. tb-specific tetramer+ CD4+ TSCM (CD45RA+ CCR7+ CD27+ were performed by microfluidic qRT-PCR, and functional and phenotypic characteristics were confirmed by measuring expression of chemokine receptors, cytotoxic molecules and cytokines using flow cytometry.ResultsM. tb-specific TSCM were not detected in QFT-negative persons. After QFT conversion frequencies of TSCM increased to measurable levels and remained detectable thereafter, suggesting that primary M. tb infection induces TSCM cells. Gene expression (GE profiling of tetramer+ TSCM showed that these cells were distinct from bulk CD4+ naïve T cells (TN and shared features of bulk TSCM and M. tb-specific tetramer+ TCM and TEFF cells. These TSCM were predominantly CD95+ and CXCR3+, markers typical of CD8+ TSCM. Tetramer+ TSCM expressed significantly higher protein levels of CCR5, CCR6, CXCR3, granzyme A, granzyme K, and granulysin than bulk TN and TSCM cells. M. tb-specific TSCM were also

Developmental biology, the stem cell of biological disciplines

OpenAIRE

Gilbert, Scott F.

2017-01-01

Developmental biology (including embryology) is proposed as "the stem cell of biological disciplines.” Genetics, cell biology, oncology, immunology, evolutionary mechanisms, neurobiology, and systems biology each has its ancestry in developmental biology. Moreover, developmental biology continues to roll on, budding off more disciplines, while retaining its own identity. While its descendant disciplines differentiate into sciences with a restricted set of paradigms, examples, and techniques, ...

[Neural representations of facial identity and its associative meaning].

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Eifuku, Satoshi

2012-07-01

Since the discovery of "face cells" in the early 1980s, single-cell recording experiments in non-human primates have made significant contributions toward the elucidation of neural mechanisms underlying face perception and recognition. In this paper, we review the recent progress in face cell studies, including the recent remarkable findings of the face patches that are scattered around the anterior temporal cortical areas of monkeys. In particular, we focus on the neural representations of facial identity within these areas. The identification of faces requires both discrimination of facial identities and generalization across facial views. It has been indicated by some laboratories that the population of face cells found in the anterior ventral inferior temporal cortex of monkeys represent facial identity in a manner which is facial view-invariant. These findings suggest a relatively distributed representation that operates for facial identification. It has also been shown that certain individual neurons in the medial temporal lobe of humans represent view-invariant facial identity. This finding suggests a relatively sparse representation that may be employed for memory formation. Finally, we summarize our recent study, showing that the population of face cells in the anterior ventral inferior temporal cortex of monkeys that represent view-invariant facial identity, can also represent learned paired associations between an abstract picture and a particular facial identity, extending our understanding of the function of the anterior ventral inferior temporal cortex in the recognition of associative meanings of faces.

Positive and negative flashbulb memories of the fall of the Berlin Wall among East- and West Germans

DEFF Research Database (Denmark)

Bohn, Annette; Berntsen, Dorthe

2006-01-01

, rehearsal and the centrality of the memory to the person's identity and life story correlated positively with memory qualities. The results suggest that positive versus negative emotions have different effects on the processing and long-term retention of flashbulb memories.......Flashbulb memories for the fall of the Berlin Wall were examined among 103 East and West Germans who considered the event as either highly positive or highly negative. Participants in the positive group rated their memories higher on measures of reliving and sensory imagery, whereas memory...

Landscape, historic memory and national identity in the beginnings of the policy nature conservation in Spain: from Covadonga to San Juan de la Peña

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Jacobo García Álvarez

2013-08-01

Full Text Available This article reflects on the concept of “national landscape” and on the importance of identity symbolic values in the beginning of landscape and nature conservation policy in Spain. The emblematic case of the Montaña de Covadonga (the first National Park created in Spain is examined in more detail. The paper is divided into three main sections. The first one raises some theoretical and general considerations on the role of identity symbolic values within the first steps of nature conservation policies in Spain and other national contexts. Secondly, the cultural-historic processes and discourses which converted the Montaña de Covadonga landscape into a Spanish national symbol and into a site of memory, leading to its declaration as a National Park in 1918, are reviewed. The third section examines the ideological identity disputes and controversies concerning the creation of that National Park, some of which led to the declaration of the Sitio Nacional del Monte de San Juan de la Peña in 1920. The article approaches the creation of the first Spanish Natural Parks as a part of the nationalization policies inspired by the concerns of the “Regeneracionismo”. More precisely, the beginning of natural conservation policy in Spain may be considered as part of the efforts carried out by certain intellectual and political leaders in order to institutionalize new spaces of collective identity grounded in landscape and nature (and, more particularly, in some natural landscapes endowed with a strong historic symbolic meaning as regards to the “birth of the nation”. According to the research conclusions, the ideological controversies raised around the first Spanish Natural Parks can be understood as a reflection of the plurality of competing national conceptions existing in Spain, as well as of the difficulties in reaching a consensus on the country’s national symbols.

Queer in STEM: Workplace Experiences Reported in a National Survey of LGBTQA Individuals in Science, Technology, Engineering, and Mathematics Careers.

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Yoder, Jeremy B; Mattheis, Allison

2016-01-01

A survey of individuals working in science, technology, engineering, and mathematics (STEM) fields who identify as lesbian, gay, bisexual, trans*, queer, or asexual (LGTBQA) was administered online in 2013. Participants completed a 58-item questionnaire to report their professional areas of expertise, levels of education, geographic location, and gender and sexual identities and rated their work and social communities as welcoming or hostile to queer identities. An analysis of 1,427 responses to this survey provided the first broad portrait of this population, and it revealed trends related to workplace practices that can inform efforts to improve queer inclusivity in STEM workplaces.

Who's in the Mirror?: Issues Surrounding the Identity Construction of Music Educators

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Roberts, Brian

2004-01-01

The article presents the text of a guest lecture delivered at Richland College in Dallas, Texas, in April 2003, by Brian A. Roberts, professor of music education at the Memorial University of Newfoundland. Speaking to an audience of music education students, he discusses his ongoing research of the identity construction of music educators (do they…

Europe without Borders: Questioning the Idea of a Common European Identity

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Loreta Georgievska-Jakovleva

2014-09-01

Full Text Available This paper aims to examine the effectiveness of the matrices of a common European identity in the European Union acts that promote this idea. This paper sets out the thesis that practical implementation of what is meant by the motto “Europe without borders” encounters at least two serious obstacles: the first related to the tendency of externalizing the violence and to see beyond the boundaries of the European Union, for example in the Balkans as another Europe, and the second is related to the asymmetry of the memory of Europe.Direct consequence of this situation is the sense of not belonging, marginalization and segregation of Europe. This thesis is examined by interpreting the implications of this sense in the process of creating cultural products in Macedonia. The ability to complete the project “Europe without borders” is considered in terms of participation of national identity and culture, seen through the analysis of artistic body of work by Milcho Manchevski (movies “Before the Rain” and “Dust” and the literary opus by Tashko Georgievski (novels “Black Seed” and “Flat Land”. The phenomenon of outsourcing the violence which refers to the subject-object relationship in culture and the phenomenon of asymmetry memory is also examined. In conclusion, it`s suggested that if Europe desires to realize allied, shared European identity, Europe must propose advanced matrixes for that reason. In this context, every political decision must include ethical consideration.

Industrial and cultural landscape: memories from a heritage of contemporaneousness

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Ronaldo André Rodrigues da Silva

2011-03-01

Full Text Available he paper presents the industrial heritage and cultural heritage concepts from the relationships established between the social and economic life from the perspective of the industrial landscape and the development of organizational landscapes. The cultural landscape is conceived from an integrated view of society and business from an endless web of interconnections that converge in the heritage and culture concepts. The relations established fall aspects of cultural and social memory and approach these concepts, providing them with an interdisciplinary characteristics. It is necessary to highlight a "specific" social-industrial landscape that determines its own identity and makes possible to know a region, a geographic space and time experienced from their surroundings and helps us understand the transformations and reflections of the conditions of life and work of individuals. Moreover, its describe factors particular of the construction of memory, identity and culture to explain social issues, expectations and limitations of a particular contemporary society. The intertwining of the history, memory and culture concepts and organization is a possibility of understanding the work relationships and society, intertwined by the socio-economic and cultural consequences. Expanding the heritage concept asset constitutes a challenge, because it allows developing memory and the cultural-industrial history and provides a greater understanding of the temporal continuity between past-present-future.

Cognitive control, attention, and the other race effect in memory.

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Brown, Thackery I; Uncapher, Melina R; Chow, Tiffany E; Eberhardt, Jennifer L; Wagner, Anthony D

2017-01-01

People are better at remembering faces from their own race than other races-a phenomenon with significant societal implications. This Other Race Effect (ORE) in memory could arise from different attentional allocation to, and cognitive control over, same- and other-race faces during encoding. Deeper or more differentiated processing of same-race faces could yield more robust representations of same- vs. other-race faces that could support better recognition memory. Conversely, to the extent that other-race faces may be characterized by lower perceptual expertise, attention and cognitive control may be more important for successful encoding of robust, distinct representations of these stimuli. We tested a mechanistic model in which successful encoding of same- and other-race faces, indexed by subsequent memory performance, is differentially predicted by (a) engagement of frontoparietal networks subserving top-down attention and cognitive control, and (b) interactions between frontoparietal networks and fusiform cortex face processing. European American (EA) and African American (AA) participants underwent fMRI while intentionally encoding EA and AA faces, and ~24 hrs later performed an "old/new" recognition memory task. Univariate analyses revealed greater engagement of frontoparietal top-down attention and cognitive control networks during encoding for same- vs. other-race faces, stemming particularly from a failure to engage the cognitive control network during processing of other-race faces that were subsequently forgotten. Psychophysiological interaction (PPI) analyses further revealed that OREs were characterized by greater functional interaction between medial intraparietal sulcus, a component of the top-down attention network, and fusiform cortex during same- than other-race face encoding. Together, these results suggest that group-based face memory biases at least partially stem from differential allocation of cognitive control and top-down attention during

The Influence of Professional Identity on Teaching Practice: Experiences of Four Music Educators

Science.gov (United States)

Carrillo, Carmen; Baguley, Margaret; Vilar, Mercè

2015-01-01

This study explores the influence of professional identity on the teaching practice of four school music educators, two from Spain and two from Australia. Narrative inquiry methodology was utilized in order to investigate the full spectrum of their musical experiences, ranging from their earliest childhood memories to their current positions in…

Noradrenergic activation of the basolateral amygdala modulates the consolidation of object-in-context recognition memory

OpenAIRE

Barsegyan, Areg; McGaugh, James L.; Roozendaal, Benno

2014-01-01

Noradrenergic activation of the basolateral complex of the amygdala (BLA) is well known to enhance the consolidation of long-term memory of highly emotionally arousing training experiences. The present study investigated whether such noradrenergic activation of the BLA also influences the consolidation of object-in-context recognition memory, a low-arousing training task assessing episodic-like memory. Male Sprague-Dawley rats were exposed to two identical objects in one context for either 3 ...

STEM Enrichment Programs and Graduate School Matriculation: The Role of Science Identity Salience

Science.gov (United States)

Merolla, David M.; Serpe, Richard T.

2013-01-01

Improving the state of science education in the United States has become a national priority. One response to this problem has been the implementation of STEM enrichment programs designed to increase the number of students that enter graduate programs in science. Current research indicates enrichment programs have positive effects for student…

Building the Rainbow Nation. A critical analysis of the role of architecture in materializing a post-apartheid South African identity

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Kim Raedt

2012-02-01

Full Text Available Soon after apartheid was abolished in 1994, the quest for a new, ‘authentic’ South African identity resulted in the emergence of the "Rainbow Nation" idea, picturing an equal, multicultural and reconciled society. As architecture is considered a crucial element in the promotion of this Rainbow identity, the country witnessed a remarkable "building boom" with its apogee roughly between 1998 and 2010. Huge investments have been made in state-driven projects which place the apartheid memory at the center of the architectural debate – mostly museums and memorials. However, the focus of this paper shall lie on another, less highlighted tendency in current architectural practice. This paper demonstrates that, through the construction of urban community services, South African architects attempt to materialize the Rainbow Nation in a way that might be closer to the everyday reality of society. Key words: architecture, post apartheid, Cape Town, South Africa, identity

The ties to unbind: Age-related differences in feature (unbinding in working memory for emotional faces

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Didem ePehlivanoglu

2014-04-01

Full Text Available In the present study, we investigated age-related differences in the processing of emotional stimuli. Specifically, we were interested in whether older adults would show deficits in unbinding emotional expression (i.e., either no emotion, happiness, anger, or disgust from bound stimuli (i.e., photographs of faces expressing these emotions, as a hyperbinding account of age-related differences in working memory would predict. Younger and older adults completed different N-Back tasks (side-by-side 0-Back, 1-Back, 2-Back under three conditions: match/mismatch judgments based on either the identity of the face (identity condition, the face’s emotional expression (expression condition, or both identity and expression of the face (binding condition. Both age groups performed more slowly and with lower accuracy in the expression condition than in the binding condition, indicating the presence of an unbinding process. This unbinding effect was more pronounced in older adults than in younger adults, but only in the 2-Back task. Thus, older adults seemed to have a specific deficit in unbinding in working memory, over and beyond age-related differences observed in perceptual processing (0-Back and attention/short-term memory (1-Back. Additionally, no age-related differences were found in accuracy in the 0-Back task, but such differences emerged in the 1-Back task, and were further magnified in the 2-Back task, indicating independent age-related differences in attention/short-term memory and working memory. Pupil dilation data confirmed that the attention/short-term memory version of the task (1-Back is more effortful in older adults than younger adults.

New Insights into the Crossroads between EMT and Stemness in the Context of Cancer

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Isabel Fabregat

2016-03-01

Full Text Available The epithelial-mesenchymal transition (EMT is an example of cellular plasticity, where an epithelial cell acquires a mesenchymal-like phenotype that increases its migratory and invasive properties. Stemness is the ability of stem cells to proliferate in an asymmetric way that allows them to maintain the reservoir of undifferentiated cells with stem cell identity, but also to produce new differentiated cells. Initial works revealed that activation of the EMT program in epithelial cells induces the acquisition of stem cell properties, which in the context of cancer may contribute to the appearance of tumor initiating cells (TIC. However, a number of groups have recently reported that mesenchymal-epithelial transition (MET is required for efficient metastatic colonization and that EMT may be not necessarily associated with stemness. In this review, we summarize recent findings that extend our knowledge about the crossroads between EMT and stemness and their relevance under physiological or pathological conditions.

Stereotypes, Warnings, and Identity-Related Variables Influence Older Adults' Susceptibility to Associative False Memory Errors.

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Smith, Amy M; Gallo, David A; Barber, Sarah J; Maddox, Keith B; Thomas, Ayanna K

2017-08-01

Activating ageist stereotypes can impair older adults' ability to remember information. This effect has been shown to be strongest for older adults who possess certain characteristics (e.g., young-old, highly educated). The present study extended this line of research to investigate the relationship between stereotyping and false memory susceptibility in older adults. We first presented older adults with lists of associated words in an incidental learning paradigm. Afterward, we manipulated whether participants were presented with stereotypes about aging and whether they were given warnings about the associative nature of the lists. Participants then completed a yes/no recognition test and answered demographic questions. Older adults in the stereotyped group were more likely to falsely recognize non-presented theme words than older adults in the control group. Further, those who were highly educated and/or retired were most likely to experience this false memory susceptibility. Similar to the research on veridical memory, these findings suggest that the effects of ageist stereotyping on older adults' false memory susceptibility may be best understood in terms of the individual differences that older adults possess. Identifying the types of people who are at risk of experiencing stereotype threat is an important step toward helping older adults avoid memory impairment in the presence of common stereotypes. © The Author 2017. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Devalued Black and Latino Racial Identities: A By-Product of STEM College Culture?

Science.gov (United States)

McGee, Ebony O.

2016-01-01

At some point most Black and Latino/a college students--even long-term high achievers--question their own abilities because of multiple forms of racial bias. The 38 high-achieving Black and Latino/a STEM study participants, who attended institutions with racially hostile academic spaces, deployed an arsenal of strategies (e.g., stereotype…

Does recall after sleep-dependent memory consolidation reinstate sensitivity to retroactive interference?

Science.gov (United States)

Deliens, Gaétane; Schmitz, Rémy; Caudron, Isaline; Mary, Alison; Leproult, Rachel; Peigneux, Philippe

2013-01-01

Previous studies have shown that newly encoded memories are more resistant to retroactive interference when participants are allowed to sleep after learning the original material, suggesting a sleep-related strengthening of memories. In the present study, we investigated delayed, long-term effects of sleep vs. sleep deprivation (SD) on the first post-training night on memory consolidation and resistance to interference. On day 1, participants learned a list of unrelated word pairs (AB), either in the morning or in the evening, then spent the post-training night in a sleep or sleep deprivation condition, in a within-subject paradigm. On day 4, at the same time of day, they learned a novel list of word pairs (AC) in which 50% of the word pairs stemmed with the same word than in the AB list, resulting in retroactive interference. Participants had then to recall items from the AB list upon presentation of the "A" stem. Recall was marginally improved in the evening, as compared to the morning learning group. Most importantly, retroactive interference effects were found in the sleep evening group only, contrary to the hypothesis that sleep exerts a protective role against intrusion by novel but similar learning. We tentatively suggest that these results can be explained in the framework of the memory reconsolidation theory, stating that exposure to similar information sets back consolidated items in a labile form again sensitive to retroactive interference. In this context, sleep might not protect against interference but would promote an update of existing episodic memories while preventing saturation of the memory network due to the accumulation of dual traces.

Does recall after sleep-dependent memory consolidation reinstate sensitivity to retroactive interference?

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Gaétane Deliens

Full Text Available Previous studies have shown that newly encoded memories are more resistant to retroactive interference when participants are allowed to sleep after learning the original material, suggesting a sleep-related strengthening of memories. In the present study, we investigated delayed, long-term effects of sleep vs. sleep deprivation (SD on the first post-training night on memory consolidation and resistance to interference. On day 1, participants learned a list of unrelated word pairs (AB, either in the morning or in the evening, then spent the post-training night in a sleep or sleep deprivation condition, in a within-subject paradigm. On day 4, at the same time of day, they learned a novel list of word pairs (AC in which 50% of the word pairs stemmed with the same word than in the AB list, resulting in retroactive interference. Participants had then to recall items from the AB list upon presentation of the "A" stem. Recall was marginally improved in the evening, as compared to the morning learning group. Most importantly, retroactive interference effects were found in the sleep evening group only, contrary to the hypothesis that sleep exerts a protective role against intrusion by novel but similar learning. We tentatively suggest that these results can be explained in the framework of the memory reconsolidation theory, stating that exposure to similar information sets back consolidated items in a labile form again sensitive to retroactive interference. In this context, sleep might not protect against interference but would promote an update of existing episodic memories while preventing saturation of the memory network due to the accumulation of dual traces.

Parading memory and re-member-ing conflict

DEFF Research Database (Denmark)

McQuaid, Sara Dybris

; Bar-Tal 1997; Cairns & Roe 2003; Mann 2005; Roudometof 2002; cf. Asmal et al. 1996). In this context, commemoration and memorialisation work to enhance and reinforce exclusive group solidarities (Abou Assi 2010; McDowel & Braniff forthcoming 2014). The study of peace processes thus demands specific...... these ways, they are vernaculars that can unsettle received or official narratives attempting to smooth over differences and anxieties in transitory times. The emotive use of collective memory to charge processes of identity formation often form part of protracted and sectarian conflict (Horowitz [1985] 2000...... understandings of the role of history and memory as conflict dynamics, as well as strategies for studying these as both critical events and as critical continuities. In Northern Ireland, parades provide a unique case for this approach as they draw on and reframe collective memories through partly ritualised...

Memory Reactivation Enables Long-Term Prevention of Interference.

Science.gov (United States)

Herszage, Jasmine; Censor, Nitzan

2017-05-22

The ability of the human brain to successively learn or perform two competing tasks constitutes a major challenge in daily function. Indeed, exposing the brain to two different competing memories within a short temporal offset can induce interference, resulting in deteriorated performance in at least one of the learned memories [1-4]. Although previous studies have investigated online interference and its effects on performance [5-13], whether the human brain can enable long-term prevention of future interference is unknown. To address this question, we utilized the memory reactivation-reconsolidation framework [2, 12] stemming from studies at the synaptic level [14-17], according to which reactivation of a memory enables its update. In a set of experiments, using the motor sequence learning task [18] we report that a unique pairing of reactivating the original memory (right hand) in synchrony with novel memory trials (left hand) prevented future interference between the two memories. Strikingly, these effects were long-term and observed a month following reactivation. Further experiments showed that preventing future interference was not due to practice per se, but rather specifically depended on a limited time window induced by reactivation of the original memory. These results suggest a mechanism according to which memory reactivation enables long-term prevention of interference, possibly by creating an updated memory trace integrating original and novel memories during the reconsolidation time window. The opportunity to induce a long-term preventive effect on memories may enable the utilization of strategies optimizing normal human learning, as well as recovery following neurological insults. Copyright © 2017 Elsevier Ltd. All rights reserved.

Verbal Working Memory Is Related to the Acquisition of Cross-Linguistic Phonological Regularities

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Evelyn Bosma

2017-09-01

Full Text Available Closely related languages share cross-linguistic phonological regularities, such as Frisian -âld [ͻ:t] and Dutch -oud [ʱut], as in the cognate pairs kâld [kͻ:t] – koud [kʱut] ‘cold’ and wâld [wͻ:t] – woud [wʱut] ‘forest’. Within Bybee’s (1995, 2001, 2008, 2010 network model, these regularities are, just like grammatical rules within a language, generalizations that emerge from schemas of phonologically and semantically related words. Previous research has shown that verbal working memory is related to the acquisition of grammar, but not vocabulary. This suggests that verbal working memory supports the acquisition of linguistic regularities. In order to test this hypothesis we investigated whether verbal working memory is also related to the acquisition of cross-linguistic phonological regularities. For three consecutive years, 5- to 8-year-old Frisian-Dutch bilingual children (n = 120 were tested annually on verbal working memory and a Frisian receptive vocabulary task that comprised four cognate categories: (1 identical cognates, (2 non-identical cognates that either do or (3 do not exhibit a phonological regularity between Frisian and Dutch, and (4 non-cognates. The results showed that verbal working memory had a significantly stronger effect on cognate category (2 than on the other three cognate categories. This suggests that verbal working memory is related to the acquisition of cross-linguistic phonological regularities. More generally, it confirms the hypothesis that verbal working memory plays a role in the acquisition of linguistic regularities.

Competitive Semantic Memory Retrieval: Temporal Dynamics Revealed by Event-Related Potentials.

Directory of Open Access Journals (Sweden)

Robin Hellerstedt

Full Text Available Memories compete for retrieval when they are related to a common retrieval cue. Previous research has shown that retrieval of a target memory may lead to subsequent retrieval-induced forgetting (RIF of currently irrelevant competing memories. In the present study, we investigated the time course of competitive semantic retrieval and examined the neurocognitive mechanisms underlying RIF. We contrasted two theoretical accounts of RIF by examining a critical aspect of this memory phenomenon, namely the extent to which it depends on successful retrieval of the target memory. Participants first studied category-exemplar word-pairs (e.g. Fruit-Apple. Next, we recorded electrophysiological measures of brain activity while the participants performed a competitive semantic cued-recall task. In this task, the participants were provided with the studied categories but they were instructed to retrieve other unstudied exemplars (e.g. Fruit-Ma__?. We investigated the event-related potential (ERP correlates of retrieval success by comparing ERPs from successful and failed retrieval trials. To isolate the ERP correlates of continuous retrieval attempts from the ERP correlates of retrieval success, we included an impossible retrieval condition, with incompletable word-stem cues (Drinks-Wy__ and compared it with a non-retrieval presentation baseline condition (Occupation-Dentist. The participants' memory for all the studied exemplars was tested in the final phase of the experiment. Taken together, the behavioural results suggest that RIF is independent of target retrieval. Beyond investigating the mechanisms underlying RIF, the present study also elucidates the temporal dynamics of semantic cued-recall by isolating the ERP correlates of retrieval attempt and retrieval success. The ERP results revealed that retrieval attempt is reflected in a late posterior negativity, possibly indicating construction of candidates for completing the word-stem cue and retrieval

Competitive Semantic Memory Retrieval: Temporal Dynamics Revealed by Event-Related Potentials

Science.gov (United States)

Hellerstedt, Robin; Johansson, Mikael

2016-01-01

Memories compete for retrieval when they are related to a common retrieval cue. Previous research has shown that retrieval of a target memory may lead to subsequent retrieval-induced forgetting (RIF) of currently irrelevant competing memories. In the present study, we investigated the time course of competitive semantic retrieval and examined the neurocognitive mechanisms underlying RIF. We contrasted two theoretical accounts of RIF by examining a critical aspect of this memory phenomenon, namely the extent to which it depends on successful retrieval of the target memory. Participants first studied category-exemplar word-pairs (e.g. Fruit—Apple). Next, we recorded electrophysiological measures of brain activity while the participants performed a competitive semantic cued-recall task. In this task, the participants were provided with the studied categories but they were instructed to retrieve other unstudied exemplars (e.g. Fruit—Ma__?). We investigated the event-related potential (ERP) correlates of retrieval success by comparing ERPs from successful and failed retrieval trials. To isolate the ERP correlates of continuous retrieval attempts from the ERP correlates of retrieval success, we included an impossible retrieval condition, with incompletable word-stem cues (Drinks—Wy__) and compared it with a non-retrieval presentation baseline condition (Occupation—Dentist). The participants’ memory for all the studied exemplars was tested in the final phase of the experiment. Taken together, the behavioural results suggest that RIF is independent of target retrieval. Beyond investigating the mechanisms underlying RIF, the present study also elucidates the temporal dynamics of semantic cued-recall by isolating the ERP correlates of retrieval attempt and retrieval success. The ERP results revealed that retrieval attempt is reflected in a late posterior negativity, possibly indicating construction of candidates for completing the word-stem cue and retrieval

Competitive Semantic Memory Retrieval: Temporal Dynamics Revealed by Event-Related Potentials.

Science.gov (United States)

Hellerstedt, Robin; Johansson, Mikael

2016-01-01

Memories compete for retrieval when they are related to a common retrieval cue. Previous research has shown that retrieval of a target memory may lead to subsequent retrieval-induced forgetting (RIF) of currently irrelevant competing memories. In the present study, we investigated the time course of competitive semantic retrieval and examined the neurocognitive mechanisms underlying RIF. We contrasted two theoretical accounts of RIF by examining a critical aspect of this memory phenomenon, namely the extent to which it depends on successful retrieval of the target memory. Participants first studied category-exemplar word-pairs (e.g. Fruit-Apple). Next, we recorded electrophysiological measures of brain activity while the participants performed a competitive semantic cued-recall task. In this task, the participants were provided with the studied categories but they were instructed to retrieve other unstudied exemplars (e.g. Fruit-Ma__?). We investigated the event-related potential (ERP) correlates of retrieval success by comparing ERPs from successful and failed retrieval trials. To isolate the ERP correlates of continuous retrieval attempts from the ERP correlates of retrieval success, we included an impossible retrieval condition, with incompletable word-stem cues (Drinks-Wy__) and compared it with a non-retrieval presentation baseline condition (Occupation-Dentist). The participants' memory for all the studied exemplars was tested in the final phase of the experiment. Taken together, the behavioural results suggest that RIF is independent of target retrieval. Beyond investigating the mechanisms underlying RIF, the present study also elucidates the temporal dynamics of semantic cued-recall by isolating the ERP correlates of retrieval attempt and retrieval success. The ERP results revealed that retrieval attempt is reflected in a late posterior negativity, possibly indicating construction of candidates for completing the word-stem cue and retrieval monitoring

Dissociating Measures of Consciousness from Measures of Short-Term Memory

DEFF Research Database (Denmark)

Sørensen, Thomas Alrik; Ásgeirsson, Árni Gunnar; Staugaard, Camilla Funch

Often, the contents of consciousness are equated with the contents of short-term memory (or working memory), sometimes to a point where they are treated as identical entities. In the present study we aimed to investigate whether they may be modulated independently and thus dissociated from each...... if conscious content simply can be reduced to a cognitive process like short-term memory. In two experiments, we combined two different measures of short-term memory capacity to investigate how manipulations of set-size affect performance in observers with the Perceptual Awareness Scale (PAS) to measure...... conscious experience of the stimulus in every trial (Ramsøy & Overgaard, 2004; Overgaard & Sørensen, 2004). We trained observers to report their experience of a visual target stimulus on the four-point PAS scale; ranging from “no experience” to “clear experience”. To measure short-term memory we used...

Strand displacement amplification for ultrasensitive detection of human pluripotent stem cells.

Science.gov (United States)

Wu, Wei; Mao, Yiping; Zhao, Shiming; Lu, Xuewen; Liang, Xingguo; Zeng, Lingwen

2015-06-30

Human pluripotent stem cells (hPSCs), such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), provide a powerful model system for studies of cellular identity and early mammalian development, which hold great promise for regenerative medicine. It is necessary to develop a convenient method to discriminate hPSCs from other cells in clinics and basic research. Herein, a simple and reliable biosensor for stem cell detection was established. In this biosensor system, stage-specific embryonic antigen-3 (SSEA-3) and stage-specific embryonic antigen-4 (SSEA-4) were used to mark human pluripotent stem cells (hPSCs). Antibody specific for SSEA-3 was coated onto magnetic beads for hPSCs enrichment, and antibody specific for SSEA-4 was conjugated with carboxyl-modified tDNA sequence which was used as template for strand displacement amplification (SDA). The amplified single strand DNA (ssDNA) was detected with a lateral flow biosensor (LFB). This biosensor is capable of detecting a minimum of 19 human embryonic stem cells by a strip reader and 100 human embryonic stem cells by the naked eye within 80min. This approach has also shown excellent specificity to distinguish hPSCs from other types of cells, showing that it is promising for specific and handy detection of human pluripotent stem cells. Copyright © 2015 Elsevier B.V. All rights reserved.

A Visual Short-Term Memory Advantage for Objects of Expertise

Science.gov (United States)

Curby, Kim M.; Glazek, Kuba; Gauthier, Isabel

2009-01-01

Visual short-term memory (VSTM) is limited, especially for complex objects. Its capacity, however, is greater for faces than for other objects; this advantage may stem from the holistic nature of face processing. If the holistic processing explains this advantage, object expertise--which also relies on holistic processing--should endow experts…

Identifying endogenous neural stem cells in the adult brain in vitro and in vivo: novel approaches.

Science.gov (United States)

Rueger, Maria Adele; Androutsellis-Theotokis, Andreas

2013-01-01

In the 1960s, Joseph Altman reported that the adult mammalian brain is capable of generating new neurons. Today it is understood that some of these neurons are derived from uncommitted cells in the subventricular zone lining the lateral ventricles, and the dentate gyrus of the hippocampus. The first area generates new neuroblasts which migrate to the olfactory bulb, whereas hippocampal neurogenesis seems to play roles in particular types of learning and memory. A part of these uncommitted (immature) cells is able to divide and their progeny can generate all three major cell types of the nervous system: neurons, astrocytes, and oligodendrocytes; these properties define such cells as neural stem cells. Although the roles of these cells are not yet clear, it is accepted that they affect functions including olfaction and learning/memory. Experiments with insults to the central nervous system also show that neural stem cells are quickly mobilized due to injury and in various disorders by proliferating, and migrating to injury sites. This suggests a role of endogenous neural stem cells in disease. New pools of stem cells are being discovered, suggesting an even more important role for these cells. To understand these cells and to coax them to contribute to tissue repair it would be very useful to be able to image them in the living organism. Here we discuss advances in imaging approaches as well as new concepts that emerge from stem cell biology with emphasis on the interface between imaging and stem cells.

Motivation for weight loss affects recall from autobiographical memory in dieters.

Science.gov (United States)

Johannessen, Kim Berg; Berntsen, Dorthe

2009-01-01

Two studies examined the connection between motivation for weight loss and autobiographical memory by comparing characteristics of autobiographical memories between dieters and non-dieters. Study 1 involved 29 normal/overweight dieters and 48 non-dieters, and Study 2 involved 18 obese dieters and 18 normal weight non-dieters. Memories recalled in response to dieting-related cue words were rated as more central to the person's identity and life story and contained more body- or weight-related elements for the dieters than the non-dieters. No differences between dieters and non-dieters were found on memories recalled in response to neutral cue words. The findings are discussed in relation to the notions of the working self (Conway & Pleydell-Pearce, 2000) and current concerns (Klinger, 1978).

Motivation for weight loss affects recall from autobiographical memory in dieters

DEFF Research Database (Denmark)

Johannessen, Kim Berg; Berntsen, Dorthe

2009-01-01

Two studies examined the connection between motivation for weight loss and autobiographical memory by comparing characteristics of autobiographical memories between dieters and non-dieters. Study 1 involved 29 normal/overweight dieters and 48 non-dieters, and Study 2 involved 18 obese dieters...... and 18 normal weight non-dieters. Memories recalled in response to dieting-related cue words were rated as more central to the person's identity and life story and contained more body- or weight-related elements for the dieters than the non-dieters. No differences between dieters and non-dieters were...... found on memories recalled in response to neutral cue words. The findings are discussed in relation to the notions of the working self (Conway & Pleydell-Pearce, 2000) and current concerns (Klinger, 1978)....

Remediating Viking Origins: Genetic Code as Archival Memory of the Remote Past.

Science.gov (United States)

Scully, Marc; King, Turi; Brown, Steven D

2013-10-01

This article introduces some early data from the Leverhulme Trust-funded research programme, 'The Impact of the Diasporas on the Making of Britain: evidence, memories, inventions'. One of the interdisciplinary foci of the programme, which incorporates insights from genetics, history, archaeology, linguistics and social psychology, is to investigate how genetic evidence of ancestry is incorporated into identity narratives. In particular, we investigate how 'applied genetic history' shapes individual and familial narratives, which are then situated within macro-narratives of the nation and collective memories of immigration and indigenism. It is argued that the construction of genetic evidence as a 'gold standard' about 'where you really come from' involves a remediation of cultural and archival memory, in the construction of a 'usable past'. This article is based on initial questionnaire data from a preliminary study of those attending DNA collection sessions in northern England. It presents some early indicators of the perceived importance of being of Viking descent among participants, notes some emerging patterns and considers the implications for contemporary debates on migration, belonging and local and national identity.

Introducing organisational heritage: Linking corporate heritage, organisational identity, and organisational memory

OpenAIRE

Balmer, JMT; Burghausen, M

2015-01-01

In this article we formally introduce and explicate the organisational heritage notion. The authors conclude organisational heritage can be designated in three broad ways as: (1) organisational heritage identity as the perceived and reminisced omni-temporal traits – both formal/normative and utilitarian/societal – of organisational members’ work organisation; (2) organisational heritage identification as organisational members’ identification/self-categorisation vis-à-vis these perceived and ...