Application of the Pareto principle to identify and address drug-therapy safety issues.

Science.gov (United States)

Müller, Fabian; Dormann, Harald; Pfistermeister, Barbara; Sonst, Anja; Patapovas, Andrius; Vogler, Renate; Hartmann, Nina; Plank-Kiegele, Bettina; Kirchner, Melanie; Bürkle, Thomas; Maas, Renke

2014-06-01

Adverse drug events (ADE) and medication errors (ME) are common causes of morbidity in patients presenting at emergency departments (ED). Recognition of ADE as being drug related and prevention of ME are key to enhancing pharmacotherapy safety in ED. We assessed the applicability of the Pareto principle (~80 % of effects result from 20 % of causes) to address locally relevant problems of drug therapy. In 752 cases consecutively admitted to the nontraumatic ED of a major regional hospital, ADE, ME, contributing drugs, preventability, and detection rates of ADE by ED staff were investigated. Symptoms, errors, and drugs were sorted by frequency in order to apply the Pareto principle. In total, 242 ADE were observed, and 148 (61.2 %) were assessed as preventable. ADE contributed to 110 inpatient hospitalizations. The ten most frequent symptoms were causally involved in 88 (80.0 %) inpatient hospitalizations. Only 45 (18.6 %) ADE were recognized as drug-related problems until discharge from the ED. A limited set of 33 drugs accounted for 184 (76.0 %) ADE; ME contributed to 57 ADE. Frequency-based listing of ADE, ME, and drugs involved allowed identification of the most relevant problems and development of easily to implement safety measures, such as wall and pocket charts. The Pareto principle provides a method for identifying the locally most relevant ADE, ME, and involved drugs. This permits subsequent development of interventions to increase patient safety in the ED admission process that best suit local needs.

Principles for social impact assessment: A critical comparison between the international and US documents

International Nuclear Information System (INIS)

Vanclay, Frank

2006-01-01

The 'International Principles for Social Impact Assessment' and the 'Principles and Guidelines for Social Impact Assessment in the USA', both developed under the auspices of the International Association for Impact Assessment and published in 2003, are compared. Major differences in the definition and approach to social impact assessment (SIA) are identified. The US Principles and Guidelines is shown to be positivist/technocratic while the International Principles is identified as being democratic, participatory and constructivist. Deficiencies in both documents are identified. The field of SIA is changing to go beyond the prevention of negative impacts, to include issues of building social capital, capacity building, good governance, community engagement and social inclusion

Developmental Principles: Fact or Fiction

Directory of Open Access Journals (Sweden)

A. J. Durston

2012-01-01

Full Text Available While still at school, most of us are deeply impressed by the underlying principles that so beautifully explain why the chemical elements are ordered as they are in the periodic table, and may wonder, with the theoretician Brian Goodwin, “whether there might be equally powerful principles that account for the awe-inspiring diversity of body forms in the living realm”. We have considered the arguments for developmental principles, conclude that they do exist and have specifically identified features that may generate principles associated with Hox patterning of the main body axis in bilaterian metazoa in general and in the vertebrates in particular. We wonder whether this exercise serves any purpose. The features we discuss were already known to us as parts of developmental mechanisms and defining developmental principles (how, and at which level? adds no insight. We also see little profit in the proposal by Goodwin that there are principles outside the emerging genetic mechanisms that need to be taken into account. The emerging developmental genetic hierarchies already reveal a wealth of interesting phenomena, whatever we choose to call them.

THE PRINCIPLE OF NON-RETROACTIVITY OF CIVIL LAW - DEVIATIONS IDENTIFIED IN THE MATTER OF TAX LEGISLATION

Directory of Open Access Journals (Sweden)

Cristina-Simona Căpăţînă (Dumitrache

2016-11-01

Full Text Available This article aims to examine the effects of the principle of non-retroactivity of law. While the first section deals with the principle of non-retroactivity of the law in terms of Romanian civil law, the next section presents cases of compliance, but also several cases of violation/breach of the principle enunciated, identified in the tax matter. By researching the date when legal acts or deeds are concluded or, as the case may be, committed or produced, in relation to the effects of the new law over them, we are submitting to a non-retroactivity test some texts from tax laws governing the obligation of the taxpayers to pay tax on profit when no longer meet the conditions to be micro -enterprises, obligation of the individuals without revenue to pay social health insurance contributions, the obligations of the persons carrying out transactions with related parties to draw up transfer pricing file. The effect of the facta pendentia situation is presented and analyzed on a specific case of transfer pricing, which may be misinterpreted as a breach of the principle of non-retroactivity of the law. Precisely for this reason the conclusions present utility both for law theorists and practitioners.

General Principles and Convention on Contracts for the International Sale of Goods (CISG – Uniformity under an Interpretation Umbrella?

Directory of Open Access Journals (Sweden)

Laura Lassila

2017-01-01

Full Text Available Globalization and digitalization of international sales creates needs to harmonize rules of international commercial contracts. The question is whether the harmonization should be done by binding rules or using soft law tools or through digitalization. In this article I argue on favor of harmonization through international contracts law rules’ international interpretation.The international interpretation principles used in this article are found from on Art. 7(1 of the Convention on Contracts for the International Sale of Goods (CISG which sets three interpretation rules: international character; promoting uniformity; and observance of good faith in international trade. These principles are not only principles of the CISG, but also principles commonly recognized in international commercial practice and also in domestic contract rules. I argue that by adopting an international interpretation umbrella – the meta-principle of international interpretation, cross-border contracts could be interpreted under the same principle no matter applicable substantial law. The meta-principle functions as an interpretation umbrella covering general principles and Articles of the CISG, general principles of international commercial contracts, Lex Mercatoria, and cross-border contract provision under national law.The outcomes points out that arbitral tribunals have interpreted general principles of the CISG and Lex Mercatoria in various ways. General principles and their application in case law is analyzed in connection with the Civil Code of the Russian Federation. Tribunals found that general principles of the CISG are applicable even if the CISG is not. It follows Art.’s 7(2 logic to promote international standard to cross-border contracts where the closes connection is international commercial practice rather than any national jurisdiction.

THE UNDERLYING PRINCIPLES OF SUSILO BAMBANG YUDHOYONO‘S THOUGHT PATTERNS IN HIS ENGLISH SPEECH TEXTS

Directory of Open Access Journals (Sweden)

Sulistya ningsih

2014-10-01

Full Text Available The underlying principles of thought patterns as shown in SBY's English Speeches Texts are made because there are different responses from the public, a part of public praise that SBY is a good president, and others claim and criticize him that  he is slow (Djalal, 2007: forward page. This title so far has not been investigated. This research was aimed at finding out:  the underlying principles of SBY’s thought patterns in his English Speech Texts related to Javanese philosophy. This research is qualitative. The data selected from SBY’s speech Texts were analyzed using semantic and pragmastylistic theory then were related to Javanese philosophy. The findings are the underlying principles of SBY’s thought patterns based on Javanese philosophy manifested in his English Speech Texts are: first is Memayu Hayuning Bawana, Ambrasta dur Hangkara means to reach safety, peace, happiness and well-being of the world and its contents, to keep the world maintained and harmony. Second, Rukun agawe santosa crah agawe bubrah  means to build the condition of harmony, and avoid conflict, because conflict can be harmful to both parties. Third, tepa selira means keep thinking not to offend others or lighten the burdens of others, tolerance. Fourth is ana rembug becik dirembug means thru negotiations can avoid conflict and achieve cooperation, safety, peace and prosperity. In sum, the world peace can be reached thru discussions without war, soft powers.

Principles, Economic and Institutional Prerequisites for Fiscal Decentralization under Conditions of Post-Conflict Reconstruction

Directory of Open Access Journals (Sweden)

Vishnevsky Valentine P.

2016-11-01

Full Text Available The aim of the article is to study principles, economic and institutional prerequisites for fiscal decentralization on post-conflict territories. It is determined that fiscal decentralization is one of the main ways to solve problems of post-conflict areas. There justified principles, economic and institutional prerequisites of fiscal decentralization on post-conflict territories with regard to the specificity of individual spheres of fiscal relations. Moreover, different spheres of fiscal relations require different approaches: the sphere of public revenues — providing economic efficiency with the formation of the tax structure contributing to the expansion of the tax base; the sphere of public spending — ensuring social justice and transparency in allocation of social cost at the local level; the sphere of subsidies — narrowing the scope of application of intergovernmental transfers with organizing the redistribution of financial resources under the principle of «center - post-conflict regions - post-conflict recipients»; the sphere of external assistance — ensuring proper coordination for cultivation of new co-operative institutions.

Temporal ventriloquism along the path of apparent motion: speed perception under different spatial grouping principles.

Science.gov (United States)

Ogulmus, Cansu; Karacaoglu, Merve; Kafaligonul, Hulusi

2018-03-01

The coordination of intramodal perceptual grouping and crossmodal interactions plays a critical role in constructing coherent multisensory percepts. However, the basic principles underlying such coordinating mechanisms still remain unclear. By taking advantage of an illusion called temporal ventriloquism and its influences on perceived speed, we investigated how audiovisual interactions in time are modulated by the spatial grouping principles of vision. In our experiments, we manipulated the spatial grouping principles of proximity, uniform connectedness, and similarity/common fate in apparent motion displays. Observers compared the speed of apparent motions across different sound timing conditions. Our results revealed that the effects of sound timing (i.e., temporal ventriloquism effects) on perceived speed also existed in visual displays containing more than one object and were modulated by different spatial grouping principles. In particular, uniform connectedness was found to modulate these audiovisual interactions in time. The effect of sound timing on perceived speed was smaller when horizontal connecting bars were introduced along the path of apparent motion. When the objects in each apparent motion frame were not connected or connected with vertical bars, the sound timing was more influential compared to the horizontal bar conditions. Overall, our findings here suggest that the effects of sound timing on perceived speed exist in different spatial configurations and can be modulated by certain intramodal spatial grouping principles such as uniform connectedness.

Principles of Islamic Finance and Principles of Corporate Social Responsibility: What Convergence?

Directory of Open Access Journals (Sweden)

Simona Franzoni

2018-02-01

Full Text Available Islamic Finance, among its other features, figures as a financial and economic model based on principles and ethical values in which sustainable development and social responsibility play an essential role. The aim of this study is to illustrate the concept of Corporate Social Responsibility (CSR with specific reference to Islamic financial institutions, their principles, values and objectives, in order to understand the underpinning dynamics and identify the convergences between the principles underlying conventional CSR and those of Islamic Finance. Specifically, the ultimate purpose of the comparison is to highlight how CSR may constitute a significant factor of convergence between Islamic and conventional finance systems, going beyond the logic of sustainability in short-term marketing policy and implementing medium- and long-term sustainability. This approach aims at increasing the potential for value creation and the pursuit of economic, social and environmental results for all stakeholders. This convergence should, finally, create conditions favourable to the harmonisation of the regulations and directives relative to CSR in the different countries, and therefore a better integration between Islamic finance institutions and conventional ones in the economic contexts.

Compression as a Universal Principle of Animal Behavior

Science.gov (United States)

Ferrer-i-Cancho, Ramon; Hernández-Fernández, Antoni; Lusseau, David; Agoramoorthy, Govindasamy; Hsu, Minna J.; Semple, Stuart

2013-01-01

A key aim in biology and psychology is to identify fundamental principles underpinning the behavior of animals, including humans. Analyses of human language and the behavior of a range of non-human animal species have provided evidence for a common pattern underlying diverse behavioral phenomena: Words follow Zipf's law of brevity (the…

Identifying Knowledge and Communication

Directory of Open Access Journals (Sweden)

Eduardo Coutinho Lourenço de Lima

2006-12-01

Full Text Available In this paper, I discuss how the principle of identifying knowledge which Strawson advances in ‘Singular Terms and Predication’ (1961, and in ‘Identifying Reference and Truth-Values’ (1964 turns out to constrain communication. The principle states that a speaker’s use of a referring expression should invoke identifying knowledge on the part of the hearer, if the hearer is to understand what the speaker is saying, and also that, in so referring, speakers are attentive to hearers’ epistemic states. In contrasting it with Russell’s Principle (Evans 1982, as well as with the principle of identifying descriptions (Donnellan 1970, I try to show that the principle of identifying knowledge, ultimately a condition for understanding, makes sense only in a situation of conversation. This allows me to conclude that the cooperative feature of communication (Grice 1975 and reference (Clark andWilkes-Gibbs 1986 holds also at the understanding level. Finally, I discuss where Strawson’s views seem to be unsatisfactory, and suggest how they might be improved.

Fundamental quadratic variational principle underlying general relativity

International Nuclear Information System (INIS)

Atkins, W.K.

1983-01-01

The fundamental result of Lanczos is used in a new type of quadratic variational principle whose field equations are the Einstein field equations together with the Yang-Mills type equations for the Riemann curvature. Additionally, a spin-2 theory of gravity for the special case of the Einstein vacuum is discussed

An ant colony optimization algorithm for phylogenetic estimation under the minimum evolution principle

Directory of Open Access Journals (Sweden)

Milinkovitch Michel C

2007-11-01

Full Text Available Abstract Background Distance matrix methods constitute a major family of phylogenetic estimation methods, and the minimum evolution (ME principle (aiming at recovering the phylogeny with shortest length is one of the most commonly used optimality criteria for estimating phylogenetic trees. The major difficulty for its application is that the number of possible phylogenies grows exponentially with the number of taxa analyzed and the minimum evolution principle is known to belong to the NP MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacPC6xNi=xH8viVGI8Gi=hEeeu0xXdbba9frFj0xb9qqpG0dXdb9aspeI8k8fiI+fsY=rqGqVepae9pg0db9vqaiVgFr0xfr=xfr=xc9adbaqaaeGacaGaaiaabeqaaeqabiWaaaGcbaWenfgDOvwBHrxAJfwnHbqeg0uy0HwzTfgDPnwy1aaceaGae8xdX7Kaeeiuaafaaa@3888@-hard class of problems. Results In this paper, we introduce an Ant Colony Optimization (ACO algorithm to estimate phylogenies under the minimum evolution principle. ACO is an optimization technique inspired from the foraging behavior of real ant colonies. This behavior is exploited in artificial ant colonies for the search of approximate solutions to discrete optimization problems. Conclusion We show that the ACO algorithm is potentially competitive in comparison with state-of-the-art algorithms for the minimum evolution principle. This is the first application of an ACO algorithm to the phylogenetic estimation problem.

The underlying principles of relativistic theory of gravitation

International Nuclear Information System (INIS)

Logunov, A.A.

1989-01-01

The paper deals with the main statements of relativistic theory of gravitation, constructed in result of critical analysis of the general theory of relativity. The principle of geometrization is formulated

Population health management guiding principles to stimulate collaboration and improve pharmaceutical care

NARCIS (Netherlands)

B. Steenkamer (Betty); C.A. Baan (Caroline); K. Putters (Kim); H.A.M. Oers (Hans); H.W. Drewes (Hanneke W.)

2018-01-01

markdownabstractPurpose: A range of strategies to improve pharmaceutical care has been implemented by population health management (PHM) initiatives. However, which strategies generate the desired outcomes is largely unknown. The purpose of this paper is to identify guiding principles underlying

Population health management guiding principles to stimulate collaboration and improve pharmaceutical care

NARCIS (Netherlands)

Steenkamer, B.M.; Baan, C.A.; Putters, Kim; van Oers, J.A.M.; Drewes, Hanneke

2018-01-01

Purpose A range of strategies to improve pharmaceutical care has been implemented by population health management (PHM) initiatives. However, which strategies generate the desired outcomes is largely unknown. The purpose of this paper is to identify guiding principles underlying collaborative

Population health management guiding principles to stimulate collaboration and improve pharmaceutical care.

NARCIS (Netherlands)

Steenkamer, Betty; Baan, Caroline; Putters, Kim; van Oers, Hans; Drewes, Hanneke

2018-01-01

Purpose A range of strategies to improve pharmaceutical care has been implemented by population health management (PHM) initiatives. However, which strategies generate the desired outcomes is largely unknown. The purpose of this paper is to identify guiding principles underlying collaborative

Principles of precision medicine in stroke.

Science.gov (United States)

Hinman, Jason D; Rost, Natalia S; Leung, Thomas W; Montaner, Joan; Muir, Keith W; Brown, Scott; Arenillas, Juan F; Feldmann, Edward; Liebeskind, David S

2017-01-01

The era of precision medicine has arrived and conveys tremendous potential, particularly for stroke neurology. The diagnosis of stroke, its underlying aetiology, theranostic strategies, recurrence risk and path to recovery are populated by a series of highly individualised questions. Moreover, the phenotypic complexity of a clinical diagnosis of stroke makes a simple genetic risk assessment only partially informative on an individual basis. The guiding principles of precision medicine in stroke underscore the need to identify, value, organise and analyse the multitude of variables obtained from each individual to generate a precise approach to optimise cerebrovascular health. Existing data may be leveraged with novel technologies, informatics and practical clinical paradigms to apply these principles in stroke and realise the promise of precision medicine. Importantly, precision medicine in stroke will only be realised once efforts to collect, value and synthesise the wealth of data collected in clinical trials and routine care starts. Stroke theranostics, the ultimate vision of synchronising tailored therapeutic strategies based on specific diagnostic data, demand cerebrovascular expertise on big data approaches to clinically relevant paradigms. This review considers such challenges and delineates the principles on a roadmap for rational application of precision medicine to stroke and cerebrovascular health. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

On the invariance principle

Energy Technology Data Exchange (ETDEWEB)

Moller-Nielsen, Thomas [University of Oxford (United Kingdom)

2014-07-01

Physicists and philosophers have long claimed that the symmetries of our physical theories - roughly speaking, those transformations which map solutions of the theory into solutions - can provide us with genuine insight into what the world is really like. According to this 'Invariance Principle', only those quantities which are invariant under a theory's symmetries should be taken to be physically real, while those quantities which vary under its symmetries should not. Physicists and philosophers, however, are generally divided (or, indeed, silent) when it comes to explaining how such a principle is to be justified. In this paper, I spell out some of the problems inherent in other theorists' attempts to justify this principle, and sketch my own proposed general schema for explaining how - and when - the Invariance Principle can indeed be used as a legitimate tool of metaphysical inference.

The precautionary principle in fisheries management under climate change: How the international legal framework formulate it?

Science.gov (United States)

Latifah, E.; Imanullah, M. N.

2018-03-01

One of the objectives of fisheries management is to reach long-term sustainable benefits of the fish stocks while reducing the risk of severe or irreversible damage to the marine ecosystem. Achieving this objective needs, the good scientific knowledge and understanding on fisheries management including scientific data and information on the fish stock, fishing catch, distribution, migration, the proportion of mature fish, the mortality rate, reproduction as well as the knowledge on the impact of fishing on dependent and associated species and other species belonging to the same ecosystem, and further the impact of climate change and climate variability on the fish stocks and marine ecosystem. Lack of this scientific knowledge may lead to high levels of uncertainty. The precautionary principle is one of the basic environmental principles needed in overcoming this problem. An essence of this principle is that, in facing the serious risk as a result of the limited scientific knowledge or the absence of complete evidence of harm, it should not prevent the precautionary measures in minimizing risks and protecting the fish stocks and ecosystem. This study aims to examine how the precautionary principle in fisheries management be formulated into the international legal framework, especially under the climate change framework.

First principles and Debye model study of the thermodynamic, electronic and optical properties of MgO under high-temperature and pressure

Science.gov (United States)

Miao, Yurun; Li, Huayang; Wang, Hongjuan; He, Kaihua; Wang, Qingbo

2018-02-01

First principles and quasi-harmonic Debye model have been used to study the thermodynamic properties, enthalpies, electronic and optical properties of MgO up to the core-mantle boundary (CMB) condition (137 GPa and 3700 K). Thermodynamic properties calculation includes thermal expansion coefficient and capacity, which have been studied up to the CMB pressure (137 GPa) and temperature (3700 K) by the Debye model with generalized gradient approximation (GGA) and local-density approximation (LDA). First principles with hybrid functional method (PBE0) has been used to calculate the electronic and optical properties under pressure up to 137 GPa and 0 K. Our results show the Debye model with LDA and first principles with PBE0 can provide accurate thermodynamic properties, enthalpies, electronic and optical properties. Calculated enthalpies show that MgO keep NaCl (B1) structure up to 137 GPa. And MgO is a direct bandgap insulator with a 7.23 eV calculated bandgap. The bandgap increased with increasing pressure, which will induce a blue shift of optical properties. We also calculated the density of states (DOS) and discussed the relation between DOS and band, optical properties. Equations were used to fit the relations between pressure and bandgaps, absorption coefficient (α(ω)) of MgO. The equations can be used to evaluate pressure after careful calibration. Our calculations can not only be used to identify some geological processes, but also offer a reference to the applications of MgO in the future.

26 CFR 1.671-2 - Applicable principles.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Applicable principles. 1.671-2 Section 1.671-2...) INCOME TAXES Grantors and Others Treated As Substantial Owners § 1.671-2 Applicable principles. (a) Under... included in a portion of the trust are set forth in § 1.671-3. (b) Since the principle underlying subpart E...

Developing "Personality" Taxonomies: Metatheoretical and Methodological Rationales Underlying Selection Approaches, Methods of Data Generation and Reduction Principles.

Science.gov (United States)

Uher, Jana

2015-12-01

Taxonomic "personality" models are widely used in research and applied fields. This article applies the Transdisciplinary Philosophy-of-Science Paradigm for Research on Individuals (TPS-Paradigm) to scrutinise the three methodological steps that are required for developing comprehensive "personality" taxonomies: 1) the approaches used to select the phenomena and events to be studied, 2) the methods used to generate data about the selected phenomena and events and 3) the reduction principles used to extract the "most important" individual-specific variations for constructing "personality" taxonomies. Analyses of some currently popular taxonomies reveal frequent mismatches between the researchers' explicit and implicit metatheories about "personality" and the abilities of previous methodologies to capture the particular kinds of phenomena toward which they are targeted. Serious deficiencies that preclude scientific quantifications are identified in standardised questionnaires, psychology's established standard method of investigation. These mismatches and deficiencies derive from the lack of an explicit formulation and critical reflection on the philosophical and metatheoretical assumptions being made by scientists and from the established practice of radically matching the methodological tools to researchers' preconceived ideas and to pre-existing statistical theories rather than to the particular phenomena and individuals under study. These findings raise serious doubts about the ability of previous taxonomies to appropriately and comprehensively reflect the phenomena towards which they are targeted and the structures of individual-specificity occurring in them. The article elaborates and illustrates with empirical examples methodological principles that allow researchers to appropriately meet the metatheoretical requirements and that are suitable for comprehensively exploring individuals' "personality".

Refugia: identifying and understanding safe havens for biodiversity under climate change

NARCIS (Netherlands)

Keppel, G.; Niel, Van K.P.; Wardell-Johnson, G.W.; Yates, C.J.; Byrne, M.; Mucina, L.; Schut, A.G.T.; Hopper, S.D.; Franklin, S.E.

2012-01-01

Aim Identifying and protecting refugia is a priority for conservation under projected anthropogenic climate change, because of their demonstrated ability to facilitate the survival of biota under adverse conditions. Refugia are habitats that components of biodiversity retreat to, persist in and can

Algorithmic Principles of Mathematical Programming

NARCIS (Netherlands)

Faigle, Ulrich; Kern, Walter; Still, Georg

2002-01-01

Algorithmic Principles of Mathematical Programming investigates the mathematical structures and principles underlying the design of efficient algorithms for optimization problems. Recent advances in algorithmic theory have shown that the traditionally separate areas of discrete optimization, linear

Principles of health information systems in developing countries.

Science.gov (United States)

Krickeberg, Klaus

The setting of this article is an all-embracing Health Information System (HIS)* of the type that exists mainly in developing and transition countries. It was inspired by work in Vietnam and other places. The article discusses the basic principles on which a well-functioning HIS needs to rest regardless of the technical means employed (paper, electronic devices). Eleven principles for designing or reforming a HIS are identified, including: explicit description of the underlying units (target population) and variables; no list of indicators to be fixed in advance; only one register per target population; technical coordination between registers and reports; correction algorithms; local use of data and indicators; autonomy of health institutions regarding the information that concerns them; and novel use of registers for various studies. Apart from their technical role, these principles give shape to the philosophy that underlies this article, and make clear that a HIS is not only a tool for collecting indicators; it is intimately tied to clinical and preventive practice, as well as to health management and health economy. In fact, it permeates the entire health system. It can potentially play a much more extended, varied, and useful role than simply that of providing health services to a community.

First-principles studies of PETN molecular crystal vibrational frequencies under high pressure

Science.gov (United States)

Perger, Warren; Zhao, Jijun

2005-07-01

The vibrational frequencies of the PETN molecular crystal were calculated using the first-principles CRYSTAL03 program which employs an all-electron LCAO approach and calculates analytic first derivatives of the total energy with respect to atomic displacements. Numerical second derivatives were used to enable calculation of the vibrational frequencies at ambient pressure and under various states of compression. Three different density functionals, B3LYP, PW91, and X3LYP were used to examine the effect of the exchange-correlation functional on the vibrational frequencies. The pressure-induced shift of the vibrational frequencies will be presented and compared with experiment. The average deviation with experimental results is shown to be on the order of 2-3%, depending on the functional used.

From bacteria to mollusks: the principles underlying the biomineralization of iron oxide materials.

Science.gov (United States)

Faivre, Damien; Godec, Tina Ukmar

2015-04-13

Various organisms possess a genetic program that enables the controlled formation of a mineral, a process termed biomineralization. The variety of biological material architectures is mind-boggling and arises from the ability of organisms to exert control over crystal nucleation and growth. The structure and composition of biominerals equip biomineralizing organisms with properties and functionalities that abiotically formed materials, made of the same mineral, usually lack. Therefore, elucidating the mechanisms underlying biomineralization and morphogenesis is of interdisciplinary interest to extract design principles that will enable the biomimetic formation of functional materials with similar capabilities. Herein, we summarize what is known about iron oxides formed by bacteria and mollusks for their magnetic and mechanical properties. We describe the chemical and biological machineries that are involved in controlling mineral precipitation and organization and show how these organisms are able to form highly complex structures under physiological conditions. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

5 CFR 551.202 - General principles.

Science.gov (United States)

2010-01-01

... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false General principles. 551.202 Section 551... ADMINISTRATION UNDER THE FAIR LABOR STANDARDS ACT Exemptions and Exclusions § 551.202 General principles. In all exemption determinations, the agency must observe the following principles: (a) Each employee is presumed to...

24 CFR 3282.402 - General principles.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false General principles. 3282.402... and Remedial Actions § 3282.402 General principles. (a) Nothing in this subpart or in these... manufactured home manufacturers to provide remedial actions under this subpart is limited by the principle that...

Identifying organisational principles and management practices important to the quality of health care services for chronic conditions

DEFF Research Database (Denmark)

Frølich, Anne

2012-01-01

are limited, it is necessary to identify efficient methods to improve the quality of care. Comparing health care systems is a well-known method for identifying new knowledge regarding, for instance, organisational methods and principles. Kaiser Permanente (KP), an integrated health care delivery system...... in the U.S., is recognized as providing high-quality chronic care; to some extent, this is due to KP's implementation of the chronic care model (CCM). This model recommends a range of evidence-based management practices that support the implementation of evidence-based medicine. However, it is not clear...... which management practices in the CCM are most efficient and in what combinations. In addition, financial incentives and public reporting of performance are often considered effective at improving the quality of health care services, but this has not yet been definitively proved....

21 CFR 822.37 - Under what circumstances would you inspect records identifying subjects?

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Under what circumstances would you inspect records identifying subjects? 822.37 Section 822.37 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH... Under what circumstances would you inspect records identifying subjects? We can inspect and copy records...

Principles underlying rational design of live attenuated influenza vaccines

Science.gov (United States)

Jang, Yo Han

2012-01-01

Despite recent innovative advances in molecular virology and the developments of vaccines, influenza virus remains a serious burden for human health. Vaccination has been considered a primary countermeasure for prevention of influenza infection. Live attenuated influenza vaccines (LAIVs) are particularly attracting attention as an effective strategy due to several advantages over inactivated vaccines. Cold-adaptation, as a classical means for attenuating viral virulence, has been successfully used for generating safe and effective donor strains of LAIVs against seasonal epidemics and occasional pandemics. Recently, the advent of reverse genetics technique expedited a variety of rational strategies to broaden the pool of LAIVs. Considering the breadth of antigenic diversity of influenza virus, the pool of LAIVs is likely to equip us with better options for controlling influenza pandemics. With a brief reflection on classical attenuating strategies used at the initial stage of development of LAIVs, especially on the principles underlying the development of cold-adapted LAIVs, we further discuss and outline other attenuation strategies especially with respect to the rationales for attenuation, and their practicality for mass production. Finally, we propose important considerations for a rational vaccine design, which will provide us with practical guidelines for improving the safety and effectiveness of LAIVs. PMID:23596576

Hooke's Law: Applications of a Recurring Principle

Science.gov (United States)

Giuliodori, Mauricio J.; Lujan, Heidi L.; Briggs, Whitney S.; Palani, Gurunanthan; DiCarlo, Stephen E.

2009-01-01

Students generally approach topics in physiology as a series of unrelated phenomena that share few underlying principles. However, if students recognized that the same underlying principles can be used to explain many physiological phenomena, they may gain a more unified understanding of physiological systems. To address this concern, we…

Biochemical principles underlying the stable maintenance of LTP by the CaMKII/NMDAR complex.

Science.gov (United States)

Lisman, John; Raghavachari, Sridhar

2015-09-24

Memory involves the storage of information at synapses by an LTP-like process. This information storage is synapse specific and can endure for years despite the turnover of all synaptic proteins. There must, therefore, be special principles that underlie the stability of LTP. Recent experimental results suggest that LTP is maintained by the complex of CaMKII with the NMDAR. Here we consider the specifics of the CaMKII/NMDAR molecular switch, with the goal of understanding the biochemical principles that underlie stable information storage by synapses. Consideration of a variety of experimental results suggests that multiple principles are involved. One switch requirement is to prevent spontaneous transitions from the off to the on state. The highly cooperative nature of CaMKII autophosphorylation by Ca(2+) (Hill coefficient of 8) and the fact that formation of the CaMKII/NMDAR complex requires release of CaMKII from actin are mechanisms that stabilize the off state. The stability of the on state depends critically on intersubunit autophosphorylation, a process that restores any loss of pT286 due to phosphatase activity. Intersubunit autophosphorylation is also important in explaining why on state stability is not compromised by protein turnover. Recent evidence suggests that turnover occurs by subunit exchange. Thus, stability could be achieved if a newly inserted unphosphorylated subunit was autophosphorylated by a neighboring subunit. Based on other recent work, we posit a novel mechanism that enhances the stability of the on state by protection of pT286 from phosphatases. We posit that the binding of the NMNDAR to CaMKII forces pT286 into the catalytic site of a neighboring subunit, thereby protecting pT286 from phosphatases. A final principle concerns the role of structural changes. The binding of CaMKII to the NMDAR may act as a tag to organize the binding of further proteins that produce the synapse enlargement that underlies late LTP. We argue that these

Principles underlying the epizootiology of viral hemorrhagic septicemia in Pacific herring and other fishes throughout the North Pacific Ocean

Science.gov (United States)

Hershberger, Paul K.; Garver, Kyle A.; Winton, James R.

2016-01-01

Although viral hemorrhagic septicemia virus (VHSV) typically occurs at low prevalence and intensity in natural populations of Pacific herring (Clupea pallasii) and other marine fishes in the Northeast Pacific Ocean, epizootics of the resulting disease (VHS) periodically occur, often in association with observed fish kills. Here we identify a list of principles, based on a combination of field studies, controlled laboratory experiments, and previously unpublished observations, that govern the epizootiology of VHS in Pacific herring. A thorough understanding of these principles provides the basis for identifying risk factors that predispose certain marine fish populations to VHS epizootics, including the lack of population resistance, presence of chronic viral carriers in a population, copious viral shedding by infected individuals, cool water temperatures, limited water circulation patterns, and gregarious host behavioral patterns. Further, these principles are used to define the epizootiological stages of the disease in Pacific herring, including the susceptible (where susceptible individuals predominate a school or subpopulation), enzootic (where infection prevalence and intensity are often below the limits of reasonable laboratory detection), disease amplification (where infection prevalence and intensity increase rapidly), outbreak (often accompanied by host mortalities with high virus loads and active shedding), recovery (in which the mortality rate and virus load decline owing to an active host immune response), and refractory stages (characterized by little or no susceptibility and where viral clearance occurs in most VHS survivors). In addition to providing a foundation for quantitatively assessing the potential risks of future VHS epizootics in Pacific herring, these principles provide insights into the epizootiology of VHS in other fish communities where susceptible species exist.

Principles of Islamic Finance and Principles of Corporate Social Responsibility: What Convergence?

OpenAIRE

Simona Franzoni; Asma Ait Allali

2018-01-01

Islamic Finance, among its other features, figures as a financial and economic model based on principles and ethical values in which sustainable development and social responsibility play an essential role. The aim of this study is to illustrate the concept of Corporate Social Responsibility (CSR) with specific reference to Islamic financial institutions, their principles, values and objectives, in order to understand the underpinning dynamics and identify the convergences between the princip...

Variational principles in physics

CERN Document Server

Basdevant, Jean-Louis

2007-01-01

Optimization under constraints is an essential part of everyday life. Indeed, we routinely solve problems by striking a balance between contradictory interests, individual desires and material contingencies. This notion of equilibrium was dear to thinkers of the enlightenment, as illustrated by Montesquieu’s famous formulation: "In all magistracies, the greatness of the power must be compensated by the brevity of the duration." Astonishingly, natural laws are guided by a similar principle. Variational principles have proven to be surprisingly fertile. For example, Fermat used variational methods to demonstrate that light follows the fastest route from one point to another, an idea which came to be known as Fermat’s principle, a cornerstone of geometrical optics. Variational Principles in Physics explains variational principles and charts their use throughout modern physics. The heart of the book is devoted to the analytical mechanics of Lagrange and Hamilton, the basic tools of any physicist. Prof. Basdev...

Efficient logistic regression designs under an imperfect population identifier.

Science.gov (United States)

Albert, Paul S; Liu, Aiyi; Nansel, Tonja

2014-03-01

Motivated by actual study designs, this article considers efficient logistic regression designs where the population is identified with a binary test that is subject to diagnostic error. We consider the case where the imperfect test is obtained on all participants, while the gold standard test is measured on a small chosen subsample. Under maximum-likelihood estimation, we evaluate the optimal design in terms of sample selection as well as verification. We show that there may be substantial efficiency gains by choosing a small percentage of individuals who test negative on the imperfect test for inclusion in the sample (e.g., verifying 90% test-positive cases). We also show that a two-stage design may be a good practical alternative to a fixed design in some situations. Under optimal and nearly optimal designs, we compare maximum-likelihood and semi-parametric efficient estimators under correct and misspecified models with simulations. The methodology is illustrated with an analysis from a diabetes behavioral intervention trial. © 2013, The International Biometric Society.

Three principles of competitive nonlinear pricing

OpenAIRE

Page Junior, Frank H.; Monteiro, P. K.

2002-01-01

We make three contributions to the theory of contracting under asymmetric information. First , we establish a competitive analog to the revelation principle which we call the implementation principle. This principle provides a complete characterization of all incentive compatible, indirect contracting mechanisms in terms of contract catalogs (or menus), and allows us to conclude that in competitive contracting situations, firms in choosing their contracting strategies can restrict attention, ...

The inconstant "principle of constancy".

Science.gov (United States)

Kanzer, M

1983-01-01

A review of the principle of constancy, as it appeared in Freud's writings, shows that it was inspired by his clinical observations, first with Breuer in the field of cathartic therapy and then through experiences in the early usage of psychoanalysis. The recognition that memories repressed in the unconscious created increasing tension, and that this was relieved with dischargelike phenomena when the unconscious was made conscious, was the basis for his claim to originality in this area. The two principles of "neuronic inertia" Freud expounded in the Project (1895), are found to offer the key to the ambiguous definition of the principle of constancy he was to offer in later years. The "original" principle, which sought the complete discharge of energy (or elimination of stimuli), became the forerunner of the death drive; the "extended" principle achieved balances that were relatively constant, but succumbed in the end to complete discharge. This was the predecessor of the life drives. The relation between the constancy and pleasure-unpleasure principles was maintained for twenty-five years largely on an empirical basis which invoked the concept of psychophysical parallelism between "quantity" and "quality." As the links between the two principles were weakened by clinical experiences attendant upon the growth of ego psychology, a revision of the principle of constancy was suggested, and it was renamed the Nirvana principle. Actually it was shifted from alignment with the "extended" principle of inertia to the original, so that "constancy" was incongruously identified with self-extinction. The former basis for the constancy principle, the extended principle of inertia, became identified with Eros. Only a few commentators seem aware of this radical transformation, which has been overlooked in the Standard Edition of Freud's writings. Physiological biases in the history and conception of the principle of constancy are noted in the Standard Edition. The historical

Lean principles applied to software development – avoiding waste

Directory of Open Access Journals (Sweden)

Ionel NAFTANAILA

2009-12-01

Full Text Available Under the current economic conditions many organizations strive to continue the trend towards adopting better software development processes, in order to take advantage of the numerous benefits that these can offer. Those benefits include quicker return on investment, better software quality, and higher customer satisfaction. To date, however, there is little body of research that can guide organizations in adopting modern software development practices, especially when it comes to Lean thinking and principles. To address this situation, the current paper identifies and structures the main wastes (or muda in Lean terms in software development as described by Lean principles, in an attempt to bring into researchers’ and practitioners’ attention Lean Software Development, a modern development methodology based on well-established practices such as Lean Manufacturing or Toyota Production System.

A cyclic symmetry principle in physics

International Nuclear Information System (INIS)

Green, H.S.; Adelaide Univ., SA

1994-01-01

Many areas of modern physics are illuminated by the application of a symmetry principle, requiring the invariance of the relevant laws of physics under a group of transformations. This paper examines the implications and some of the applications of the principle of cyclic symmetry, especially in the areas of statistical mechanics and quantum mechanics, including quantized field theory. This principle requires invariance under the transformations of a finite group, which may be a Sylow π-group, a group of Lie type, or a symmetric group. The utility of the principle of cyclic invariance is demonstrated in finding solutions of the Yang-Baxter equation that include and generalize known solutions. It is shown that the Sylow π-groups have other uses, in providing a basis for a type of generalized quantum statistics, and in parametrising a new generalization of Lie groups, with associated algebras that include quantized algebras. 31 refs

Structural, Mechanical and Thermodynamic Properties under Pressure Effect of Rubidium Telluride: First Principle Calculations

Directory of Open Access Journals (Sweden)

Bidai K.

2017-06-01

Full Text Available First-principles density functional theory calculations have been performed to investigate the structural, elastic and thermodynamic properties of rubidium telluride in cubic anti-fluorite (anti-CaF2-type structure. The calculated ground-state properties of Rb2Te compound such as equilibrium lattice parameter and bulk moduli are investigated by generalized gradient approximation (GGA-PBE that are based on the optimization of total energy. The elastic constants, Young’s and shear modulus, Poisson ratio, have also been calculated. Our results are in reasonable agreement with the available theoretical and experimental data. The pressure dependence of elastic constant and thermodynamic quantities under high pressure are also calculated and discussed.

48 CFR 252.231-7000 - Supplemental cost principles.

Science.gov (United States)

2010-10-01

... principles. 252.231-7000 Section 252.231-7000 Federal Acquisition Regulations System DEFENSE ACQUISITION... of Provisions And Clauses 252.231-7000 Supplemental cost principles. As prescribed in 231.100-70, use the following clause: Supplemental Cost Principles (DEC 1991) When the allowability of costs under...

Assessing vulnerability to drought: identifying underlying factors across Europe

Science.gov (United States)

Urquijo, Julia; Gonzalez Tánago, Itziar; Ballesteros, Mario; De Stefano, Lucia

2015-04-01

Drought is considered one of the most severe and damaging natural hazards in terms of people and sectors affected and associated losses. Drought is a normal and recurrent climatic phenomenon that occurs worldwide, although its spatial and temporal characteristics vary significantly among climates. In the case of Europe, in the last thirty years, the region has suffered several drought events that have caused estimated economic damages over a €100 billion and have affected almost 20% of its territory and population. In recent years, there has been a growing awareness among experts and authorities of the need to shift from a reactive crisis approach to a drought risk management approach, as well as of the importance of designing and implementing policies, strategies and plans at country and river basin levels to deal with drought. The identification of whom and what is vulnerable to drought is a central aspect of drought risk mitigation and planning and several authors agree that societal vulnerability often determines drought risk more than the actual precipitation shortfalls. The final aim of a drought vulnerability assessment is to identify the underlying sources of drought impact, in order to develop policy options that help to enhance coping capacity and therefore to prevent drought impact. This study identifies and maps factors underlying vulnerability to drought across Europe. The identification of factors influencing vulnerability starts from the analysis of past drought impacts in four European socioeconomic sectors. This analysis, along with an extensive literature review, led to the selection of vulnerability factors that are both relevant and adequate for the European context. Adopting the IPCC model, vulnerability factors were grouped to describe exposure, sensitivity and adaptive capacity. The aggregation of these components has resulted in the mapping of vulnerability to drought across Europe at NUTS02 level. Final results have been compared with

Electronic Topological Transitions in CuNiMnAl and CuNiMnSn under pressure from first principles study

Science.gov (United States)

Rambabu, P.; Kanchana, V.

2018-06-01

A detailed study on quaternary ordered full Heusler alloys CuNiMnAl and CuNiMnSn at ambient and under different compressions is presented using first principles electronic structure calculations. Both the compounds are found to possess ferromagnetic nature at ambient with magnetic moment of Mn being 3.14 μB and 3.35 μB respectively in CuNiMnAl and CuNiMnSn. The total magnetic moment for both the compounds is found to decrease under compression. Fermi surface (FS) topology change is observed in both compounds under pressure at V/V0 = 0.90, further leading to Electronic Topological Transitions (ETTs) and is evidenced by the anomalies visualized in density of states and elastic constants under compression.

5 CFR 551.401 - Basic principles.

Science.gov (United States)

2010-01-01

... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Basic principles. 551.401 Section 551.401 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY ADMINISTRATION UNDER THE FAIR LABOR STANDARDS ACT Hours of Work General Provisions § 551.401 Basic principles. (a) All time...

Formative Assessment Using Social Marketing Principles to Identify Health and Nutrition Perspectives of Native American Women Living within the Chickasaw Nation Boundaries in Oklahoma

Science.gov (United States)

Parker, Stephany; Hunter, Toma; Briley, Chiquita; Miracle, Sarah; Hermann, Janice; Van Delinder, Jean; Standridge, Joy

2011-01-01

Objective: To identify health product and promotion channels for development of a Chickasaw Nation Supplemental Nutrition Assistance Education Program (SNAP-Ed) social marketing program. Methods: The study was qualitative and used social marketing principles to assess Native American women's views of health and nutrition. Focus groups (n = 8) and…

Principles for Implementing Modularity in Healthcare

DEFF Research Database (Denmark)

Soffers, Ruter; Meijboom, Bert; Hsuan, Juliana

in a modular way. We identify three principles to do so: 1) the service architecture should be decomposable; 2) a proper service specification process should be introduced; and 3) the presence of interfaces should be ensured. Followingthese principles should help policy makers as well as managers to implement...

Cosmological principles. II. Physical principles

International Nuclear Information System (INIS)

Harrison, E.R.

1974-01-01

The discussion of cosmological principle covers the uniformity principle of the laws of physics, the gravitation and cognizability principles, and the Dirac creation, chaos, and bootstrap principles. (U.S.)

The structural, mechanical, and electronic properties of LiAlB{sub 4} under pressure from first principles

Energy Technology Data Exchange (ETDEWEB)

Tayran, Ceren; Aydin, Sezgin [Department of Physics, Sciences Faculty, Gazi University, 06500, Ankara (Turkey)

2017-05-15

The structural, elastic, mechanical, and electronic properties of lithium aluminum tetraboride (LiAlB{sub 4}) under hydrostatic pressure have been investigated by using first-principles density functional theory calculations. The effects of pressure on the lattice parameters, volume, and bond lengths are studied. It is indicated from the calculated elastic constants that LiAlB{sub 4} compound is mechanically stable on 0-40 GPa pressure range. And, by means of these elastic constants set, some mechanical properties such as bulk, shear and Young's moduli, and then Poisson's ratio are determined as a function of pressure. Also, the ductile or brittle nature of LiAlB{sub 4} is examined. Additionally, using the first-principles data obtained from the geometry optimizations, the hardness of LiAlB{sub 4} is calculated, and its nature is investigated under pressure. Furthermore, in order to reveal the effects of pressure on the electronic and binding behavior of the compound, band structures, total and partial density of states, charge densities, Mulliken atomic charges, and bond overlap populations are searched as a function of pressure. To check the stability of the compound, phonon dispersion curves are calculated. And, the results are compared with the other convenient borides. (copyright 2017 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

The LeChatelier-Samuelson principle revisited

NARCIS (Netherlands)

Dietzenbacher, E

1992-01-01

Within the context of a linear Leontief model, the LeChatelier-Samuelson principle examines the effects of an increase in some final demand on the output levels under the constraint that the production of certain goods is held at its original value. The principle states that the increase in any

31 CFR 29.321 - General principle.

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false General principle. 29.321 Section 29.321 Money and Finance: Treasury Office of the Secretary of the Treasury FEDERAL BENEFIT PAYMENTS UNDER....321 General principle. Any service performed after June 30, 1997, may never be credited toward Federal...

31 CFR 29.341 - General principle.

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false General principle. 29.341 Section 29.341 Money and Finance: Treasury Office of the Secretary of the Treasury FEDERAL BENEFIT PAYMENTS UNDER... Benefit Payments § 29.341 General principle. Except for disability retirements after June 30, 1997, and...

31 CFR 29.331 - General principle.

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false General principle. 29.331 Section 29.331 Money and Finance: Treasury Office of the Secretary of the Treasury FEDERAL BENEFIT PAYMENTS UNDER... Satisfied by June 30, 1997 § 29.331 General principle. To determine whether service is creditable for the...

38 CFR 70.30 - Payment principles.

Science.gov (United States)

2010-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Payment principles. 70.30 Section 70.30 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) VHA BENEFICIARY TRAVEL UNDER 38 U.S.C. 111 § 70.30 Payment principles. (a) Subject to the other provisions of this...

Principles of European Contract Law

DEFF Research Database (Denmark)

Lando, Ole; Beale, Hugh

This text provides a comprehensive guide to the principles of European contract law. They have been drawn up by an independent body of experts from each Member State of the EU, under a project supported by the European Commission and many other organizations. The principles are stated in the form...... of articles, with a detailed commentary explaining the purpose and operation of each article and its relation to the remainder. Each article also has extensive comparative notes surveying the national laws and other international provisions on the topic. "The Principles of European Contract Law Parts I &...... in developing a common European legal culture. The European Parliament has twice called for the creation of a European Civil Code. The principles of European contract law are essential steps in these projects. This text provides a comprehensive guide to the Principles of European contract law. They have been...

The four variational principles of mechanics

International Nuclear Information System (INIS)

Gray, C.G.; Karl, G.; Novikov, V.A.

1996-01-01

We argue that there are four basic forms of the variational principles of mechanics: Hamilton close-quote s least action principle (HP), the generalized Maupertuis principle (MP), and their two reciprocal principles, RHP and RMP. This set is invariant under reciprocity and Legendre transformations. One of these forms (HP) is in the literature: only special cases of the other three are known. The generalized MP has a weaker constraint compared to the traditional formulation, only the mean energy bar E is kept fixed between virtual paths. This reformulation of MP alleviates several weaknesses of the old version. The reciprocal Maupertuis principle (RMP) is the classical limit of Schroedinger close-quote s variational principle of quantum mechanics, and this connection emphasizes the importance of the reciprocity transformation for variational principles. Two unconstrained formulations (UHP and UMP) of these four principles are also proposed, with completely specified Lagrange multipliers Percival close-quote s variational principle for invariant tori and variational principles for scattering orbits are derived from the RMP. The RMP is very convenient for approximate variational solutions to problems in mechanics using Ritz type methods Examples are provided. Copyright copyright 1996 Academic Press, Inc

Consolidated principles for screening based on a systematic review and consensus process.

Science.gov (United States)

Dobrow, Mark J; Hagens, Victoria; Chafe, Roger; Sullivan, Terrence; Rabeneck, Linda

2018-04-09

In 1968, Wilson and Jungner published 10 principles of screening that often represent the de facto starting point for screening decisions today; 50 years on, are these principles still the right ones? Our objectives were to review published work that presents principles for population-based screening decisions since Wilson and Jungner's seminal publication, and to conduct a Delphi consensus process to assess the review results. We conducted a systematic review and modified Delphi consensus process. We searched multiple databases for articles published in English in 1968 or later that were intended to guide population-based screening decisions, described development and modification of principles, and presented principles as a set or list. Identified sets were compared for basic characteristics (e.g., number, categorization), a citation analysis was conducted, and principles were iteratively synthesized and consolidated into categories to assess evolution. Participants in the consensus process assessed the level of agreement with the importance and interpretability of the consolidated screening principles. We identified 41 sets and 367 unique principles. Each unique principle was coded to 12 consolidated decision principles that were further categorized as disease/condition, test/intervention or program/system principles. Program or system issues were the focus of 3 of Wilson and Jungner's 10 principles, but comprised almost half of all unique principles identified in the review. The 12 consolidated principles were assessed through 2 rounds of the consensus process, leading to specific refinements to improve their relevance and interpretability. No gaps or missing principles were identified. Wilson and Jungner's principles are remarkably enduring, but increasingly reflect a truncated version of contemporary thinking on screening that does not fully capture subsequent focus on program or system principles. Ultimately, this review and consensus process provides a

Consolidated principles for screening based on a systematic review and consensus process

Science.gov (United States)

Hagens, Victoria; Chafe, Roger; Sullivan, Terrence; Rabeneck, Linda

2018-01-01

BACKGROUND: In 1968, Wilson and Jungner published 10 principles of screening that often represent the de facto starting point for screening decisions today; 50 years on, are these principles still the right ones? Our objectives were to review published work that presents principles for population-based screening decisions since Wilson and Jungner’s seminal publication, and to conduct a Delphi consensus process to assess the review results. METHODS: We conducted a systematic review and modified Delphi consensus process. We searched multiple databases for articles published in English in 1968 or later that were intended to guide population-based screening decisions, described development and modification of principles, and presented principles as a set or list. Identified sets were compared for basic characteristics (e.g., number, categorization), a citation analysis was conducted, and principles were iteratively synthesized and consolidated into categories to assess evolution. Participants in the consensus process assessed the level of agreement with the importance and interpretability of the consolidated screening principles. RESULTS: We identified 41 sets and 367 unique principles. Each unique principle was coded to 12 consolidated decision principles that were further categorized as disease/condition, test/intervention or program/system principles. Program or system issues were the focus of 3 of Wilson and Jungner’s 10 principles, but comprised almost half of all unique principles identified in the review. The 12 consolidated principles were assessed through 2 rounds of the consensus process, leading to specific refinements to improve their relevance and interpretability. No gaps or missing principles were identified. INTERPRETATION: Wilson and Jungner’s principles are remarkably enduring, but increasingly reflect a truncated version of contemporary thinking on screening that does not fully capture subsequent focus on program or system principles

21 CFR 502.5 - General principles.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 6 2010-04-01 2010-04-01 false General principles. 502.5 Section 502.5 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS... principles. (a) The common or usual name of a food, which may be a coined term, shall accurately identify or...

Principles of development of the industry of technogenic waste processing

Directory of Open Access Journals (Sweden)

Maria A. Bayeva

2014-01-01

Full Text Available Objective to identify and substantiate the principles of development of the industry of technogenic waste processing. Methods systemic analysis and synthesis method of analogy. Results basing on the analysis of the Russian and foreign experience in the field of waste management and environmental protection the basic principles of development activities on technogenic waste processing are formulated the principle of legal regulation the principle of efficiency technologies the principle of ecological safety the principle of economic support. The importance of each principle is substantiated by the description of the situation in this area identifying the main problems and ways of their solution. Scientific novelty the fundamental principles of development of the industry of the industrial wastes processing are revealed the measures of state support are proposed. Practical value the presented theoretical conclusions and proposals are aimed primarily on theoretical and methodological substantiation and practical solutions to modern problems in the sphere of development of the industry of technogenic waste processing.

General principles of radiotherapy

International Nuclear Information System (INIS)

Easson, E.C.

1985-01-01

The daily practice of any established branch of medicine should be based on some acceptable principles. This chapter is concerned with the general principles on which the radiotherapy of the Manchester school is based. Though many radiotherapists in other centres would doubtless accept these principles, there are sufficiently wide differences in practice throughout the world to suggest that some therapists adhere to a fundamentally different philosophy. The authors believe it is important, especially for those beginning their formal training in radiotherapy, to subscribe to an internally consistent school of thought, employing methods of treatment for each type of lesion in each anatomical site that are based on accepted principles and subjected to continuous rigorous scrutiny to test their effectiveness. Not only must each therapeutic technique be evaluated, but the underlying principles too must be questioned if and when this seems indicated. It is a feature of this hospital that similar lesions are all treated by the same technique, so long as statistical evidence justifies such a policy. All members of the staff adhere to the accepted policy until or unless reliable reasons are adduced to change this policy

Robust design principles for reducing variation in functional performance

DEFF Research Database (Denmark)

Christensen, Martin Ebro; Howard, Thomas J.

2016-01-01

This paper identifies, describes and classifies a comprehensive collection of variation reduction principles (VRP) that can be used to increase the robustness of a product and reduce its variation in functional performance. Performance variation has a negative effect on the reliability and percei......This paper identifies, describes and classifies a comprehensive collection of variation reduction principles (VRP) that can be used to increase the robustness of a product and reduce its variation in functional performance. Performance variation has a negative effect on the reliability...... and perceived quality of a product and efforts should be made to minimise it. The design principles are identified by a systematic decomposition of the Taguchi Transfer Function in combination with the use of existing literature and the authors’ experience. The paper presents 15 principles and describes...... their advantages and disadvantages along with example cases. Subsequently, the principles are classified based on their applicability in the various development and production stages. The VRP are to be added to existing robust design methodologies, helping the designer to think beyond robust design tool and method...

Physical principles underlying the experimental methods for studying the orientational order of liquid crystals

International Nuclear Information System (INIS)

Limmer, S.

1989-01-01

The basic physical principles underlying different experimental methods frequently used for the determination of orientational order parameters of liquid crystals are reviewed. The methods that are dealt with here include the anisotropy of the diamagnetic susceptibility, birefringence, linear dichroism, Raman scattering, fluorescence depolarization, electron paramagnetic resonance (EPR), and nuclear magnetic resonance (NMR). The fundamental assertions that can be obtained by the different methods as well as their advantages, drawbacks and limitations are inspected. Typical sources of uncertainties and inaccuracies are discussed. To quantitatively evaluate the experimental data with reference to the orientational order the general tensor formalism developed by Schmiedel was employed throughout according to which the order matrix comprises 25 real elements yet. Within this context the interplay of orientational ordering and molecular conformation is scrutinized. (author)

Goals and Principles of Environmental Policy

International Nuclear Information System (INIS)

Zylicz, T.

2010-01-01

This paper looks at how contemporary environmental (including climate) policy problems are phrased in terms of effectiveness, efficiency, and equity. The latter three concepts have served as foci of theoretical discussions among economists who analyse these issues and identify criteria that determine relevant regulations and programmes adopted by governments. The paper starts with a discussion of Pigouvian taxation as model instrument used in order to solve policy problems. It analyses to what extent and under what circumstances alternative instruments - such as marketable pollution permits - can achieve environmental and climate goals while serving other purposes too. Coase theorem is used as a reference for discussing what government interventions are indeed indispensable to achieve both explicit and tacit policy goals. Popular principles and practically applied 'rules of thumb' - such as the Polluter Pays Principle - are then reviewed. The next part is devoted to examining market structures as they influence environmental outcomes of economic activities. This is followed by a discussion of Environmental Tax Reforms which seems to inspire much of the economic thinking about contemporary policies. An outlook for the 21st century concludes the paper.

Understanding libertarian morality: the psychological dispositions of self-identified libertarians.

Directory of Open Access Journals (Sweden)

Ravi Iyer

Full Text Available Libertarians are an increasingly prominent ideological group in U.S. politics, yet they have been largely unstudied. Across 16 measures in a large web-based sample that included 11,994 self-identified libertarians, we sought to understand the moral and psychological characteristics of self-described libertarians. Based on an intuitionist view of moral judgment, we focused on the underlying affective and cognitive dispositions that accompany this unique worldview. Compared to self-identified liberals and conservatives, libertarians showed 1 stronger endorsement of individual liberty as their foremost guiding principle, and weaker endorsement of all other moral principles; 2 a relatively cerebral as opposed to emotional cognitive style; and 3 lower interdependence and social relatedness. As predicted by intuitionist theories concerning the origins of moral reasoning, libertarian values showed convergent relationships with libertarian emotional dispositions and social preferences. Our findings add to a growing recognition of the role of personality differences in the organization of political attitudes.

Understanding Libertarian Morality: The Psychological Dispositions of Self-Identified Libertarians

Science.gov (United States)

Iyer, Ravi; Koleva, Spassena; Graham, Jesse; Ditto, Peter; Haidt, Jonathan

2012-01-01

Libertarians are an increasingly prominent ideological group in U.S. politics, yet they have been largely unstudied. Across 16 measures in a large web-based sample that included 11,994 self-identified libertarians, we sought to understand the moral and psychological characteristics of self-described libertarians. Based on an intuitionist view of moral judgment, we focused on the underlying affective and cognitive dispositions that accompany this unique worldview. Compared to self-identified liberals and conservatives, libertarians showed 1) stronger endorsement of individual liberty as their foremost guiding principle, and weaker endorsement of all other moral principles; 2) a relatively cerebral as opposed to emotional cognitive style; and 3) lower interdependence and social relatedness. As predicted by intuitionist theories concerning the origins of moral reasoning, libertarian values showed convergent relationships with libertarian emotional dispositions and social preferences. Our findings add to a growing recognition of the role of personality differences in the organization of political attitudes. PMID:22927928

Understanding libertarian morality: the psychological dispositions of self-identified libertarians.

Science.gov (United States)

Iyer, Ravi; Koleva, Spassena; Graham, Jesse; Ditto, Peter; Haidt, Jonathan

2012-01-01

Libertarians are an increasingly prominent ideological group in U.S. politics, yet they have been largely unstudied. Across 16 measures in a large web-based sample that included 11,994 self-identified libertarians, we sought to understand the moral and psychological characteristics of self-described libertarians. Based on an intuitionist view of moral judgment, we focused on the underlying affective and cognitive dispositions that accompany this unique worldview. Compared to self-identified liberals and conservatives, libertarians showed 1) stronger endorsement of individual liberty as their foremost guiding principle, and weaker endorsement of all other moral principles; 2) a relatively cerebral as opposed to emotional cognitive style; and 3) lower interdependence and social relatedness. As predicted by intuitionist theories concerning the origins of moral reasoning, libertarian values showed convergent relationships with libertarian emotional dispositions and social preferences. Our findings add to a growing recognition of the role of personality differences in the organization of political attitudes.

Remedial principles and meaningful engagement in education ...

African Journals Online (AJOL)

This article evaluates the meaningful engagement doctrine in the education rights jurisprudence of the Constitutional Court in the light of a set of normative principles developed by Susan Sturm for evaluating participatory public law remedies. It commences by identifying four principles for evaluating participatory remedies ...

Four Practical Principles for Enhancing Vocabulary Instruction

Science.gov (United States)

Manyak, Patrick C.; Von Gunten, Heather; Autenrieth, David; Gillis, Carolyn; Mastre-O'Farrell, Julie; Irvine-McDermott, Elizabeth; Baumann, James F.; Blachowicz, Camille L. Z.

2014-01-01

This article presents four practical principles that lead to enhanced word-meaning instruction in the elementary grades. The authors, a collaborative team of researchers and classroom teachers, identified and developed these principles and related instructional activities during a three-year vocabulary instruction research project. The principles…

Principles of effective USA federal fire management plans

Science.gov (United States)

Meyer, Marc D.; Roberts, Susan L.; Wills, Robin; Brooks, Matthew L.; Winford, Eric M.

2015-01-01

Federal fire management plans are essential implementation guides for the management of wildland fire on federal lands. Recent changes in federal fire policy implementation guidance and fire science information suggest the need for substantial changes in federal fire management plans of the United States. Federal land management agencies are also undergoing land management planning efforts that will initiate revision of fire management plans across the country. Using the southern Sierra Nevada as a case study, we briefly describe the underlying framework of fire management plans, assess their consistency with guiding principles based on current science information and federal policy guidance, and provide recommendations for the development of future fire management plans. Based on our review, we recommend that future fire management plans be: (1) consistent and compatible, (2) collaborative, (3) clear and comprehensive, (4) spatially and temporally scalable, (5) informed by the best available science, and (6) flexible and adaptive. In addition, we identify and describe several strategic guides or “tools” that can enhance these core principles and benefit future fire management plans in the following areas: planning and prioritization, science integration, climate change adaptation, partnerships, monitoring, education and communication, and applied fire management. These principles and tools are essential to successfully realize fire management goals and objectives in a rapidly changing world.

Progress in classical and quantum variational principles

International Nuclear Information System (INIS)

Gray, C G; Karl, G; Novikov, V A

2004-01-01

We review the development and practical uses of a generalized Maupertuis least action principle in classical mechanics in which the action is varied under the constraint of fixed mean energy for the trial trajectory. The original Maupertuis (Euler-Lagrange) principle constrains the energy at every point along the trajectory. The generalized Maupertuis principle is equivalent to Hamilton's principle. Reciprocal principles are also derived for both the generalized Maupertuis and the Hamilton principles. The reciprocal Maupertuis principle is the classical limit of Schroedinger's variational principle of wave mechanics and is also very useful to solve practical problems in both classical and semiclassical mechanics, in complete analogy with the quantum Rayleigh-Ritz method. Classical, semiclassical and quantum variational calculations are carried out for a number of systems, and the results are compared. Pedagogical as well as research problems are used as examples, which include nonconservative as well as relativistic systems. '... the most beautiful and important discovery of Mechanics.' Lagrange to Maupertuis (November 1756)

The Principle-Based Method of Practical Ethics.

Science.gov (United States)

Spielthenner, Georg

2017-09-01

This paper is about the methodology of doing practical ethics. There is a variety of methods employed in ethics. One of them is the principle-based approach, which has an established place in ethical reasoning. In everyday life, we often judge the rightness and wrongness of actions by their conformity to principles, and the appeal to principles plays a significant role in practical ethics, too. In this paper, I try to provide a better understanding of the nature of principle-based reasoning. To accomplish this, I show in the first section that these principles can be applied to cases in a meaningful and sufficiently precise way. The second section discusses the question how relevant applying principles is to the resolution of ethical issues. This depends on their nature. I argue that the principles under consideration in this paper should be interpreted as presumptive principles and I conclude that although they cannot be expected to bear the weight of definitely resolving ethical problems, these principles can nevertheless play a considerable role in ethical research.

Evolutionary principles and their practical application.

Science.gov (United States)

Hendry, Andrew P; Kinnison, Michael T; Heino, Mikko; Day, Troy; Smith, Thomas B; Fitt, Gary; Bergstrom, Carl T; Oakeshott, John; Jørgensen, Peter S; Zalucki, Myron P; Gilchrist, George; Southerton, Simon; Sih, Andrew; Strauss, Sharon; Denison, Robert F; Carroll, Scott P

2011-03-01

Evolutionary principles are now routinely incorporated into medicine and agriculture. Examples include the design of treatments that slow the evolution of resistance by weeds, pests, and pathogens, and the design of breeding programs that maximize crop yield or quality. Evolutionary principles are also increasingly incorporated into conservation biology, natural resource management, and environmental science. Examples include the protection of small and isolated populations from inbreeding depression, the identification of key traits involved in adaptation to climate change, the design of harvesting regimes that minimize unwanted life-history evolution, and the setting of conservation priorities based on populations, species, or communities that harbor the greatest evolutionary diversity and potential. The adoption of evolutionary principles has proceeded somewhat independently in these different fields, even though the underlying fundamental concepts are the same. We explore these fundamental concepts under four main themes: variation, selection, connectivity, and eco-evolutionary dynamics. Within each theme, we present several key evolutionary principles and illustrate their use in addressing applied problems. We hope that the resulting primer of evolutionary concepts and their practical utility helps to advance a unified multidisciplinary field of applied evolutionary biology.

Engageability: a new sub-principle of the learnability principle in human-computer interaction

Directory of Open Access Journals (Sweden)

B Chimbo

2011-12-01

Full Text Available The learnability principle relates to improving the usability of software, as well as users’ performance and productivity. A gap has been identified as the current definition of the principle does not distinguish between users of different ages. To determine the extent of the gap, this article compares the ways in which two user groups, adults and children, learn how to use an unfamiliar software application. In doing this, we bring together the research areas of human-computer interaction (HCI, adult and child learning, learning theories and strategies, usability evaluation and interaction design. A literature survey conducted on learnability and learning processes considered the meaning of learnability of software applications across generations. In an empirical investigation, users aged from 9 to 12 and from 35 to 50 were observed in a usability laboratory while learning to use educational software applications. Insights that emerged from data analysis showed different tactics and approaches that children and adults use when learning unfamiliar software. Eye tracking data was also recorded. Findings indicated that subtle re- interpretation of the learnability principle and its associated sub-principles was required. An additional sub-principle, namely engageability was proposed to incorporate aspects of learnability that are not covered by the existing sub-principles. Our re-interpretation of the learnability principle and the resulting design recommendations should help designers to fulfill the varying needs of different-aged users, and improve the learnability of their designs. Keywords: Child computer interaction, Design principles, Eye tracking, Generational differences, human-computer interaction, Learning theories, Learnability, Engageability, Software applications, Uasability Disciplines: Human-Computer Interaction (HCI Studies, Computer science, Observational Studies

Principle of natural and artificial radioactive series equivalency

International Nuclear Information System (INIS)

Vasilyeva, A.N.; Starkov, O.V.

2001-01-01

In the present paper one approach used under development of radioactive waste management conception is under consideration. This approach is based on the principle of natural and artificial radioactive series radiotoxic equivalency. The radioactivity of natural and artificial radioactive series has been calculated for 10 9 - years period. The toxicity evaluation for natural and artificial series has also been made. The correlation between natural radioactive series and their predecessors - actinides produced in thermal and fast reactors - has been considered. It has been shown that systematized reactor series data had great scientific significance and the principle of differential calculation of radiotoxicity was necessary to realize long-lived radioactive waste and uranium and thorium ore radiotoxicity equivalency conception. The calculations show that the execution of equivalency principle is possible for uranium series (4n+2, 4n+1). It is a problem for thorium. series. This principle is impracticable for neptunium series. (author)

Evaluating the Atrial Myopathy Underlying Atrial Fibrillation: Identifying the Arrhythmogenic and Thrombogenic Substrate

Science.gov (United States)

Goldberger, Jeffrey J.; Arora, Rishi; Green, David; Greenland, Philip; Lee, Daniel C.; Lloyd-Jones, Donald M.; Markl, Michael; Ng, Jason; Shah, Sanjiv J.

2015-01-01

Atrial disease or myopathy forms the substrate for atrial fibrillation (AF) and underlies the potential for atrial thrombus formation and subsequent stroke. Current diagnostic approaches in patients with AF focus on identifying clinical predictors with evaluation of left atrial size by echocardiography serving as the sole measure specifically evaluating the atrium. Although the atrial substrate underlying AF is likely developing for years prior to the onset of AF, there is no current evaluation to identify the pre-clinical atrial myopathy. Atrial fibrosis is one component of the atrial substrate that has garnered recent attention based on newer MRI techniques that have been applied to visualize atrial fibrosis in humans with prognostic implications regarding success of treatment. Advanced ECG signal processing, echocardiographic techniques, and MRI imaging of fibrosis and flow provide up-to-date approaches to evaluate the atrial myopathy underlying AF. While thromboembolic risk is currently defined by clinical scores, their predictive value is mediocre. Evaluation of stasis via imaging and biomarkers associated with thrombogenesis may provide enhanced approaches to assess risk for stroke in patients with AF. Better delineation of the atrial myopathy that serves as the substrate for AF and thromboembolic complications might improve treatment outcomes. Furthermore, better delineation of the pathophysiologic mechanisms underlying the development of the atrial substrate for AF, particularly in its earlier stages, could help identify blood and imaging biomarkers that could be useful to assess risk for developing new onset AF and suggest specific pathways that could be targeted for prevention. PMID:26216085

TOP PRIORITI QMS PRINCIPLES FOR ACHIEVING BUSINESS EXCELLENCE

Directory of Open Access Journals (Sweden)

Aleksandar Vujović

2010-06-01

Full Text Available The main target of this paper is to select top priority principles of QMS for achieving business excellence. This could be done from the standpoint of significant of principles. That means that. organization should make more attention to this principles in the way for making excellent results. This paper has been developed as a tendency of researchers in the Center for quality-Faculty of mechanical engineering in Podgorica to establish a model for improvement of business processes performances based on quality management system through comparison with top organizational performances characterized by criteria i.e. particularities of the business excellence model. Correlation of principles of the quality management system with QMS principles has been established to that effect. Weight coefficients have been also determined for each principle individually. Thereby key principles were identified, namely priorities in terms of achieving business excellence i.e. areas (principles were given priorities, that is to say principles that play the biggest part in achieving business excellence.

Principles of Good Practice in SoTL

Science.gov (United States)

Felten, Peter

2013-01-01

For the Scholarship of Teaching and Learning (SoTL) to be understood as significant intellectual work in the academy, SoTL practitioners need to identify shared principles of good practice. While honoring the diversity of SoTL in its many forms across the globe, such principles can serve as a heuristic for assessing work in our field. These…

45 CFR 1355.25 - Principles of child and family services.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Principles of child and family services. 1355.25 Section 1355.25 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN... § 1355.25 Principles of child and family services. The following principles, most often identified by...

Taylor Principle Supplements the Fisher Effect: Empirical Investigation under the US Context

Directory of Open Access Journals (Sweden)

Mohammed Saiful ISLAM

2012-06-01

Full Text Available This paper reviews the short- and long-run dynamics of interest rate and inflation of the United States. Basing upon quarterly as well as monthly data over the period 1957 to 2010, we find evidence that interest rate behaviour of the Federal Reserve is consistent with the Taylor principle in short run and with the Fisher hypothesis in long run. Entire sample justifies the existence of a long run cointegrating relationship between federal funds rate and inflation characterised as the Fisher effect. When data are split into different subsamples, the cointegrating relationship disappears. Interest rate dynamics of pre-1980 and post-2001 neither track Fisher hypothesis nor Taylor principle, rather represent substantial discretion.

Can Evolutionary Principles Explain Patterns of Family Violence?

Science.gov (United States)

Archer, John

2013-01-01

The article's aim is to evaluate the application of the evolutionary principles of kin selection, reproductive value, and resource holding power to the understanding of family violence. The principles are described in relation to specific predictions and the mechanisms underlying these. Predictions are evaluated for physical violence perpetrated…

Identifying the bad guy in a lineup using confidence judgments under deadline pressure.

Science.gov (United States)

Brewer, Neil; Weber, Nathan; Wootton, David; Lindsay, D Stephen

2012-10-01

Eyewitness-identification tests often culminate in witnesses not picking the culprit or identifying innocent suspects. We tested a radical alternative to the traditional lineup procedure used in such tests. Rather than making a positive identification, witnesses made confidence judgments under a short deadline about whether each lineup member was the culprit. We compared this deadline procedure with the traditional sequential-lineup procedure in three experiments with retention intervals ranging from 5 min to 1 week. A classification algorithm that identified confidence criteria that optimally discriminated accurate from inaccurate decisions revealed that decision accuracy was 24% to 66% higher under the deadline procedure than under the traditional procedure. Confidence profiles across lineup stimuli were more informative than were identification decisions about the likelihood that an individual witness recognized the culprit or correctly recognized that the culprit was not present. Large differences between the maximum and the next-highest confidence value signaled very high accuracy. Future support for this procedure across varied conditions would highlight a viable alternative to the problematic lineup procedures that have traditionally been used by law enforcement.

A first-principles generic methodology for representing the knowledge base of a process diagnostic expert system

International Nuclear Information System (INIS)

Reifman, J.; Briggs, L.L.; Wei, T.Y.C.

1990-01-01

In this paper we present a methodology for identifying faulty component candidates of process malfunctions through basic physical principles of conservation, functional classification of components and information from the process schematics. The basic principles of macroscopic balance of mass, momentum and energy in thermal hydraulic control volumes are applied in a novel approach to incorporate deep knowledge into the knowledge base. Additional deep knowledge is incorporated through the functional classification of process components according to their influence in disturbing the macroscopic balance equations. Information from the process schematics is applied to identify the faulty component candidates after the type of imbalance in the control volumes is matched against the functional classification of the components. Except for the information from the process schematics, this approach is completely general and independent of the process under consideration. The use of basic first-principles, which are physically correct, and the process-independent architecture of the diagnosis procedure allow for the verification and validation of the system. A prototype process diagnosis expert system is developed and a test problem is presented to identify faulty component candidates in the presence of a single failure in a hypothetical balance of plant of a liquid metal nuclear reactor plant

Ab initio identified design principles of solid-solution strengthening in Al

International Nuclear Information System (INIS)

Ma Duancheng; Friák, Martin; Pezold, Johann von; Raabe, Dierk; Neugebauer, Jörg

2013-01-01

Solid-solution strengthening in six Al–X binary systems is investigated using first-principle methods. The volumetric mismatch parameter and the solubility enthalpy per solute were calculated. We derive three rules for designing solid-solution strengthened alloys: (i) the solubility enthalpy per solute is related to the volumetric mismatch by a power law; (ii) for each annealing temperature, there exists an optimal solute–volume mismatch to achieve maximum strength; and (iii) the strengthening potential of high volumetric mismatch solutes is severely limited by their low solubility. Our results thus show that the thermodynamic properties of the system (here Al–X alloys) set clear upper bounds to the achievable strengthening effects owing to the reduced solubility with increasing volume mismatch. (paper)

Nonsymmetric entropy and maximum nonsymmetric entropy principle

International Nuclear Information System (INIS)

Liu Chengshi

2009-01-01

Under the frame of a statistical model, the concept of nonsymmetric entropy which generalizes the concepts of Boltzmann's entropy and Shannon's entropy, is defined. Maximum nonsymmetric entropy principle is proved. Some important distribution laws such as power law, can be derived from this principle naturally. Especially, nonsymmetric entropy is more convenient than other entropy such as Tsallis's entropy in deriving power laws.

Principles and applications of tribology

CERN Document Server

Moore, Desmond F

1975-01-01

Principles and Applications of Tribology provides a mechanical engineering perspective of the fundamental understanding and applications of tribology. This book is organized into two parts encompassing 16 chapters that cover the principles of friction and different types of lubrication. Chapter 1 deals with the immense scope of tribology and the range of applications in the existing technology, and Chapter 2 is devoted entirely to the evaluation and measurement of surface texture. Chapters 3 to 5 present the fundamental concepts underlying the friction of metals, elastomers, and other material

Fiber optics principles and practices

CERN Document Server

Al-Azzawi, Abdul

2007-01-01

Since the invention of the laser, our fascination with the photon has led to one of the most dynamic and rapidly growing fields of technology. New advances in fiber optic devices, components, and materials make it more important than ever to stay current. Comprising chapters drawn from the author's highly anticipated book Photonics: Principles and Practices, Fiber Optics: Principles and Practices offers a detailed and focused treatment for anyone in need of authoritative information on this critical area underlying photonics.Using a consistent approach, the author leads you step-by-step throug

First principles molecular dynamics of metal/water interfaces under bias potential

Science.gov (United States)

Pedroza, Luana; Brandimarte, Pedro; Rocha, Alexandre; Fernandez-Serra, Marivi

2014-03-01

Understanding the interaction of the water-metal system at an atomic level is extremely important in electrocatalysts for fuel cells, photocatalysis among other systems. The question of the interface energetics involves a detailed study of the nature of the interactions between water-water and water-substrate. A first principles description of all components of the system is the most appropriate methodology in order to advance understanding of electrochemically processes. In this work we describe, using first principles molecular dynamics simulations, the dynamics of a combined surface(Au and Pd)/water system both in the presence and absence of an external bias potential applied to the electrodes, as one would come across in electrochemistry. This is accomplished using a combination of density functional theory (DFT) and non-equilibrium Green's functions methods (NEGF), thus accounting for the fact that one is dealing with an out-of-equilibrium open system, with and without van der Waals interactions. DOE Early Career Award No. DE-SC0003871.

The structural, elastic, electronic properties and Debye temperature of Ni3Mo under pressure from first-principles

International Nuclear Information System (INIS)

Qi, Lei; Jin, Yuchun; Zhao, Yuhong; Yang, Xiaomin; Zhao, Hui; Han, Peide

2015-01-01

Highlights: • Structural, elastic, electronic properties and Debye temperature under pressure. • Higher hardness of Ni 3 Mo compound may be obtained when pressure increases. • Proper pressure can improve the ductility but excess pressure was just the opposite. • Ni 3 Mo compound has no structural phase transformation under pressure up to 30 GPa. • Debye temperatures increase with increasing pressure. - Abstract: With the help of first principles method based on density functional theory, the structural, elastic, electronic properties and Debye temperature of Ni 3 Mo binary compound under pressure are investigated. Our calculated structural parameters are in good agreement with experimental and previous theoretical results. The obtained elastic constants show that Ni 3 Mo compound is mechanically stable. Elastic properties such as bulk modulus B, shear modulus G, Young’s modulus E and Poisson’s ratio υ are calculated by the Voigt–Reuss–Hill method. The results of B/G under various pressures show that proper pressure can improve the ductility of Ni 3 Mo but excess pressure will make the ductility decrease. In addition, the density of states as a function of pressure is analyzed. The Debye temperature Θ D calculated from elastic constants increases along with the pressure

Traditional ecological knowledge: Applying principles of sustainability to wilderness resource management

Science.gov (United States)

Nancy C. Ratner; Davin L. Holen

2007-01-01

Traditional ecological knowledge within specific cultural and geographical contexts was explored during an interactive session at the 8th World Wilderness Congress to identify traditional principles of sustainability. Participants analyzed the traditional knowledge contained in ten posters from Canada and Alaska and identified and discussed the traditional principles...

The precautionary principle as a rational decision criterion

International Nuclear Information System (INIS)

Hovi, Jon

2001-12-01

The paper asks if the precautionary principle may be seen as a rational decision criterion. Six main questions are discussed. 1. Does the principle basically represent a particular set of political options or is it a genuine decision criterion? 2. If it is the latter, can it be reduced to any of the existing criteria for decision making under uncertainty? 3. In what kinds of situation is the principle applicable? 4. What is the relation between the precautionary principle and other principles for environmental regulation? 5. How plausible is the principle's claim that the burden of proof should be reversed? 6. Do the proponents of environmental regulation carry no burden of proof at all? A main conclusion is that, for now at least, the principle contains too many unclear elements to satisfy the requirements of precision and consistency that should reasonably be satisfied by a rational decision criterion. (author)

Connecting Corporate Human Rights Responsibilities and State Obligations under the UN Guiding Principles

DEFF Research Database (Denmark)

Buhmann, Karin

2017-01-01

Taking its point of departure in the UN Guiding Principles on Business and Human Rights (UNGP), this chapter discusses the complementarity between Pillars One on the State Duty to Respect and Pillar Two the Corporate Responsibility to Respect Human Rights. It does this through HRDD and communicat......Taking its point of departure in the UN Guiding Principles on Business and Human Rights (UNGP), this chapter discusses the complementarity between Pillars One on the State Duty to Respect and Pillar Two the Corporate Responsibility to Respect Human Rights. It does this through HRDD...

The principle of proportionality revisited: interpretations and applications.

Science.gov (United States)

Hermerén, Göran

2012-11-01

The principle of proportionality is used in many different contexts. Some of these uses and contexts are first briefly indicated. This paper focusses on the use of this principle as a moral principle. I argue that under certain conditions the principle of proportionality is helpful as a guide in decision-making. But it needs to be clarified and to be used with some flexibility as a context-dependent principle. Several interpretations of the principle are distinguished, using three conditions as a starting point: importance of objective, relevance of means, and most favourable option. The principle is then tested against an example, which suggests that a fourth condition, focusing on non-excessiveness, needs to be added. I will distinguish between three main interpretations of the principle, some primarily with uses in research ethics, others with uses in other areas of bioethics, for instance in comparisons of therapeutic means and ends. The relations between the principle of proportionality and the precautionary principle are explored in the following section. It is concluded that the principles are different and may even clash. In the next section the principle of proportionality is applied to some medical examples drawn from research ethics and bioethics. In concluding, the status of the principle of proportionality as a moral principle is discussed. What has been achieved so far and what remains to be done is finally summarized.

Principles of calcite dissolution in human and artificial otoconia.

Directory of Open Access Journals (Sweden)

Leif Erik Walther

Full Text Available Human otoconia provide mechanical stimuli to deflect hair cells of the vestibular sensory epithelium for purposes of detecting linear acceleration and head tilts. During lifetime, the volume and number of otoconia are gradually reduced. In a process of degeneration morphological changes occur. Structural changes in human otoconia are assumed to cause vertigo and balance disorders such as benign paroxysmal positional vertigo (BPPV. The aim of this study was to investigate the main principles of morphological changes in human otoconia in dissolution experiments by exposure to hydrochloric acid, EDTA, demineralized water and completely purified water respectively. For comparison reasons artificial (biomimetic otoconia (calcite gelatin nanocomposits and natural calcite were used. Morphological changes were detected in time steps by the use of environmental scanning electron microscopy (ESEM. Under in vitro conditions three main dissolution mechanisms were identified as causing characteristic morphological changes of the specimen under consideration: pH drops in the acidic range, complex formation with calcium ions and changes of ion concentrations in the vicinity of otoconia. Shifts in pH cause a more uniform reduction of otoconia size (isotropic dissolution whereas complexation reactions and changes of the ionic concentrations within the surrounding medium bring about preferred attacks at specific areas (anisotropic dissolution of human and artificial otoconia. Owing to successive reduction of material, all the dissolution mechanisms finally produce fragments and remnants of otoconia. It can be assumed that the organic component of otoconia is not significantly attacked under the given conditions. Artificial otoconia serve as a suitable model system mimicking chemical attacks on biogenic specimens. The underlying principles of calcite dissolution under in vitro conditions may play a role in otoconia degeneration processes such as BPPV.

Dynamic principle for ensemble control tools.

Science.gov (United States)

Samoletov, A; Vasiev, B

2017-11-28

Dynamical equations describing physical systems in contact with a thermal bath are commonly extended by mathematical tools called "thermostats." These tools are designed for sampling ensembles in statistical mechanics. Here we propose a dynamic principle underlying a range of thermostats which is derived using fundamental laws of statistical physics and ensures invariance of the canonical measure. The principle covers both stochastic and deterministic thermostat schemes. Our method has a clear advantage over a range of proposed and widely used thermostat schemes that are based on formal mathematical reasoning. Following the derivation of the proposed principle, we show its generality and illustrate its applications including design of temperature control tools that differ from the Nosé-Hoover-Langevin scheme.

Principle of space existence and De Sitter metric

International Nuclear Information System (INIS)

Mal'tsev, V.K.

1990-01-01

The selection principle for the solutions of the Einstein equations suggested in a series of papers implies the existence of space (g ik ≠ 0) only in the presence of matter (T ik ≠0). This selection principle (principle of space existence, in the Markov terminology) implies, in the general case, the absence of the cosmological solution with the De Sitter metric. On the other hand, the De Sitter metric is necessary for describing both inflation and deflation periods of the Universe. It is shown that the De Sitter metric is also allowed by the selection principle under discussion if the metric experiences the evolution into the Friedmann metric

The role of socio-technical principles in leveraging meaningful benefits from IT investments.

Science.gov (United States)

Doherty, Neil F

2014-03-01

In recent years there has been a great deal of academic and practitioner interest in the role of 'benefits realisation management' [BRM] approaches, as a means of proactively leveraging value from IT investments. This growing body of work owes a very considerable, but as yet unacknowledged, debt to the work of Ken Eason, and other early socio-technical theorists. Consequently, the aim of this paper is to demonstrate, using the literature, how many of the principles, practices and techniques of BRM have evolved either directly or indirectly from socio-technical approaches to systems design. In so doing, this article makes a further important contribution to the literature by explicitly identifying the underlying principles and key practices of benefits realisation management. Copyright © 2012 Elsevier Ltd and The Ergonomics Society. All rights reserved.

What's good for the goose is good for the gander. Guiding principles for the use of financial incentives in health behaviour change.

Science.gov (United States)

Lynagh, Marita C; Sanson-Fisher, Rob W; Bonevski, Billie

2013-03-01

The use of financial incentives or pay-for-performance programs for health care providers has triggered emerging interest in the use of financial incentives for encouraging health behaviour change. This paper aims to identify key conditions under which the use of financial incentives for improvements in public health outcomes is most likely to be effective and appropriate. We review recent systematic reviews on their effectiveness in changing health behaviour and identify existing moral concerns concerning personal financial incentives. Current evidence indicates that incentives can be effective in driving health behaviour change under certain provisos, while a number of misgivings continue to be deliberated on. We outline a number of key principles for consideration in decisions about the potential use of incentives in leading to public health improvements. These key principles can assist policy makers in making decisions on the use of financial incentives directed at achieving improvements in public health.

42 CFR 405.740 - Principles for determining the amount in controversy.

Science.gov (United States)

2010-10-01

... 42 Public Health 2 2010-10-01 2010-10-01 false Principles for determining the amount in... Reconsiderations and Appeals Under Medicare Part A § 405.740 Principles for determining the amount in controversy... more appellants, the Secretary may assert that the aggregation principles contained in this subpart may...

Formative assessment using social marketing principles to identify health and nutrition perspectives of Native American women living within the Chickasaw Nation boundaries in Oklahoma.

Science.gov (United States)

Parker, Stephany; Hunter, Toma; Briley, Chiquita; Miracle, Sarah; Hermann, Janice; Van Delinder, Jean; Standridge, Joy

2011-01-01

To identify health product and promotion channels for development of a Chickasaw Nation Supplemental Nutrition Assistance Education Program (SNAP-Ed) social marketing program. The study was qualitative and used social marketing principles to assess Native American women's views of health and nutrition. Focus groups (n = 8) and interviews (n = 4) were conducted to identify indigenous views of product, promotion, price, and place related to SNAP-Ed behavioral objectives. The major theme identified for product was diabetes prevention. Participants (n = 42) indicated a preference for family-based education with promotion by elders, tribal leaders, and "everyday people." Participants identified tribe-specific community sites for program implementation at times conducive to work schedules. Culturally appropriate social marketing programs are necessary to address diabetes prevention with a focus on family, heritage, and tribal community. Additional research is necessary to explore the role of elders and tribal leaders in diabetes prevention efforts. Copyright © 2011 Society for Nutrition Education. Published by Elsevier Inc. All rights reserved.

Infrared and Raman Spectroscopy Principles and Spectral Interpretation

CERN Document Server

Larkin, Peter

2011-01-01

Infrared and Raman Spectroscopy: Principles and Spectral Interpretation explains the background, core principles and tests the readers understanding of the important techniques of Infrared and Raman Spectroscopy. These techniques are used by chemists, environmental scientists, forensic scientists etc to identify unknown chemicals. In the case of an organic chemist these tools are part of an armory of techniques that enable them to conclusively prove what compound they have made, which is essential for those being used in medical applications. The book reviews basic principles, instrumentation

A structured policy review of the principles of professional self-regulation.

Science.gov (United States)

Benton, D C; González-Jurado, M A; Beneit-Montesinos, J V

2013-03-01

The International Council of Nurses (ICN) has, for many years, based its work on professional self-regulation on a set of 12 principles. These principles are research based and were identified nearly three decades ago. ICN has conducted a number of reviews of the principles; however, changes have been minimal. In the past 5-10 years, a number of authors and governments, often as part of the review of regulatory systems, have started to propose principles to guide the way regulatory frameworks are designed and implemented. These principles vary in number and content. This study examines the current policy literature on principle-based regulation and compares this with the set of principles advocated by the ICN. A systematic search of the literature on principle-based regulation is used as the basis for a qualitative thematic analysis to compare and contrast the 12 principles of self-regulation with more recently published work. A mapping of terms based on a detailed description of the principles used in the various research and policy documents was generated. This mapping forms the basis of a critique of the current ICN principles. A professional self-regulation advocated by the ICN were identified. A revised and extended set of 13 principles is needed if contemporary developments in the field of regulatory frameworks are to be accommodated. These revised principles should be considered for adoption by the ICN to underpin their advocacy work on professional self-regulation. © 2013 The Authors. International Nursing Review © 2013 International Council of Nurses.

First-principles investigations on structural, elastic, electronic properties and Debye temperature of orthorhombic Ni3Ta under pressure

Science.gov (United States)

Li, Pan; Zhang, Jianxin; Ma, Shiyu; Jin, Huixin; Zhang, Youjian; Zhang, Wenyang

2018-06-01

The structural, elastic, electronic properties and Debye temperature of Ni3Ta under different pressures are investigated using the first-principles method based on density functional theory. Our calculated equilibrium lattice parameters at 0 GPa well agree with the experimental and previous theoretical results. The calculated negative formation enthalpies and elastic constants both indicate that Ni3Ta is stable under different pressures. The bulk modulus B, shear modulus G, Young's modulus E and Poisson's ratio ν are calculated by the Voigt-Reuss-Hill method. The bigger ratio of B/G indicates Ni3Ta is ductile and the pressure can improve the ductility of Ni3Ta. In addition, the results of density of states and the charge density difference show that the stability of Ni3Ta is improved by the increasing pressure. The Debye temperature ΘD calculated from elastic modulus increases along with the pressure.

What are the core ideas behind the Precautionary Principle?

Science.gov (United States)

Persson, Erik

2016-07-01

The Precautionary Principle is both celebrated and criticized. It has become an important principle for decision making, but it is also subject to criticism. One problem that is often pointed out with the principle is that is not clear what it actually says and how to use it. I have taken on this problem by performing an analysis of some of the most influential formulations of the principle in an attempt to identify the core ideas behind it, with the purpose of producing a formulation of the principle that is clear and practically applicable. It was found that what is called the Precautionary Principle is not a principle that tells us what do to achieve extra precaution or how to handle situations when extra precaution is called for. Instead, it was found to be a list of circumstances that each justify extra precaution. An analysis of some of the most common and influential formulations of the Precautionary Principle identified four such circumstances: (1) When we deal with important values that tend to be systematically downplayed by traditional decision methods - such as human health and the environment. (2) When we suspect that the decision might lead to irreversible and severe consequences and the values at stake are also irreplaceable, (3) When timing is at least as important as being right. (4) When it is more important to avoid false negatives than false positives. This interpretation of the Precautionary Principle does not say anything about what kind of actions to take when extra precaution is called for, but it does provide a clear and practically useful list of circumstances that call for extra precaution and that is not subject to the most common objections to the Precautionary Principle. Copyright © 2016 Elsevier B.V. All rights reserved.

On minimizers of causal variational principles

International Nuclear Information System (INIS)

Schiefeneder, Daniela

2011-01-01

Causal variational principles are a class of nonlinear minimization problems which arise in a formulation of relativistic quantum theory referred to as the fermionic projector approach. This thesis is devoted to a numerical and analytic study of the minimizers of a general class of causal variational principles. We begin with a numerical investigation of variational principles for the fermionic projector in discrete space-time. It is shown that for sufficiently many space-time points, the minimizing fermionic projector induces non-trivial causal relations on the space-time points. We then generalize the setting by introducing a class of causal variational principles for measures on a compact manifold. In our main result we prove under general assumptions that the support of a minimizing measure is either completely timelike, or it is singular in the sense that its interior is empty. In the examples of the circle, the sphere and certain flag manifolds, the general results are supplemented by a more detailed analysis of the minimizers. (orig.)

Fundamental Tactical Principles of Soccer: A Comparison of Different Age Groups.

Science.gov (United States)

Borges, Paulo Henrique; Guilherme, José; Rechenchosky, Leandro; da Costa, Luciane Cristina Arantes; Rinadi, Wilson

2017-09-01

The fundamental tactical principles of the game of soccer represent a set of action rules that guide behaviours related to the management of game space. The aim of this study was to compare the performance of fundamental offensive and defensive tactical principles among youth soccer players from 12 to 17 years old. The sample consisted of 3689 tactical actions performed by 48 soccer players in three age categories: under 13 (U-13), under 15 (U-15), and under 17 (U-17). Tactical performance was measured using the System of Tactical Assessment in Soccer (FUT-SAT). The Kruskal Wallis, Mann-Whitney U, Friedman, Wilcoxon, and Cohen's Kappa tests were used in the study analysis. The results showed that the principles of "offensive coverage" (p = 0.01) and "concentration" (p = 0.04) were performed more frequently by the U-17 players than the U-13 players. The tactical principles "width and length" (p principles are performed varies between the gaming categories, which implies that there is valuation of defensive security and a progressive increase in "offensive coverage" caused by increased confidence and security in offensive actions.

Urban Principle of Water Sensitive Design in Kampung Kamboja at Pontianak City

Science.gov (United States)

Hasriyanti, N.; Ryanti, E.

2017-07-01

This study will define the design principles of settlement area banks of the Kapuas Pontianak to approach the concept of water sensitive urban design (WSUD) in densely populated residential areas. Using a case study of a region densely located on the banks of the river with engineering literature to formulate the aspects taken into consideration and the components are arranged in the design, analysis descriptive paradigm rationalistic to identify the characteristics of residential areas riverbank with consideration of elements WSUD and formulate design principles residential area that is sensitive to water. This research is important to do because of problems related to the water management system in the settlement bank of the river in the city of Pontianak do not maximize. So that the primacy of this study contains several objectives to be achieved is to identify the characteristics of the settlement area riverbanks under consideration aspects areas design that is sensitive to water and principle areas design that will formulate the structure of the existing problems related to the needs of the community infrastructure facilities infrastructure neighborhoods and formulate and create guidelines for appropriate technology for integrated water management systems in the residential area of the riverbank and engineering design for the settlements are sensitive to water (WSUD). The final aim of the study is expected to achieve water management systems in residential areas by utilizing the abundant rainwater availability by using LID (Low Impact Development) through the concept of urban design that sensitive water

HEALTH TECHNOLOGY ASSESSMENT FOR DECISION MAKING IN LATIN AMERICA: GOOD PRACTICE PRINCIPLES.

Science.gov (United States)

Pichon-Riviere, Andrés; Soto, Natalie C; Augustovski, Federico Ariel; García Martí, Sebastián; Sampietro-Colom, Laura

2018-06-11

The aim of this study was to identify good practice principles for health technology assessment (HTA) that are the most relevant and of highest priority for application in Latin America and to identify potential barriers to their implementation in the region. HTA good practice principles proposed at the international level were identified and then explored during a deliberative process in a forum of assessors, funders, and product manufacturers. Forty-two representatives from ten Latin American countries participated. Good practice principles proposed at the international level were considered valid and potentially relevant to Latin America. Five principles were identified as priority and with the greatest potential to be strengthened at this time: transparency in the production of HTA, involvement of relevant stakeholders in the HTA process, mechanisms to appeal decisions, clear priority-setting processes in HTA, and a clear link between HTA and decision making. The main challenge identified was to find a balance between the application of these principles and the available resources in a way that would not detract from the production of reports and adaptation to the needs of decision makers. The main recommendation was to progress gradually in strengthening HTA and its link to decision making by developing appropriate processes for each country, without trying to impose, in the short-term, standards taken from examples at the international level without adequate adaptation of these to local contexts.

Music-evoked emotions: principles, brain correlates, and implications for therapy.

Science.gov (United States)

Koelsch, Stefan

2015-03-01

This paper describes principles underlying the evocation of emotion with music: evaluation, resonance, memory, expectancy/tension, imagination, understanding, and social functions. Each of these principles includes several subprinciples, and the framework on music-evoked emotions emerging from these principles and subprinciples is supposed to provide a starting point for a systematic, coherent, and comprehensive theory on music-evoked emotions that considers both reception and production of music, as well as the relevance of emotion-evoking principles for music therapy. © 2015 New York Academy of Sciences.

Wildland fire and fuel management: principles for effective communication

Science.gov (United States)

Eric Toman; Bruce Shindler

2006-01-01

In this paper we discuss four principles identified through recent research for effective citizen-agency communication and examine their use in accomplishing fire management objectives. Principles include the following: (1) effective communication is a product of effective planning; (2) both unidirectional (one-way) and interactive approaches are part of successful...

First-principles calculation of transport property in nano-devices under an external magnetic field

International Nuclear Information System (INIS)

Chen Jingzhe; Zhang Jin; Han Rushan

2008-01-01

The mesoscopic quantum interference phenomenon (QIP) can be observed and behaves as the oscillation of conductance in nano-devices when the external magnetic field changes. Excluding the factor of impurities or defects, specific QIP is determined by the sample geometry. We have improved a first-principles method based on the matrix Green's function and the density functional theory to simulate the transport behaviour of such systems under a magnetic field. We have studied two kinds of QIP: universal conductance fluctuation (UCF) and Aharonov–Bohm effect (A–B effect). We find that the amplitude of UCF is much smaller than the previous theoretical prediction. We have discussed the origin of difference and concluded that due to the failure of ergodic hypothesis, the ensemble statistics is not applicable, and the conductance fluctuation is determined by the flux-dependent density of states (DOSs). We have also studied the relation between the UCF and the structure of sample. For a specific structure, an atomic circle, the A–B effect is observed and the origin of the oscillation is also discussed

[Health technology assessment for decision-making in Latin America: good practice principles].

Science.gov (United States)

Pichon-Riviere, Andrés; Soto, Natalie C; Augustovski, Federico Ariel; García Martí, Sebastián; Sampietro-Colom, Laura

2018-02-19

Identify the most relevant, applicable, and priority good practice principles in health technology assessment (HTA) in Latin America, and potential barriers to implementing them in the region. HTA good practice principles postulated worldwide were identified and then explored through a deliberative process in a forum of evaluators, funders, and technology producers. Forty-two representatives from ten Latin American countries participated in the forum. The good practice principles postulated at the international level were considered valid and potentially applicable in Latin America. Five principles were identified as priorities and as having greater potential to be expanded at this time: transparency in carrying out HTA; involvement of stakeholders in the HTA process; existence of mechanisms to appeal decisions; existence of clear mechanisms for HTA priority-setting; and existence of a clear link between assessment and decision-making. The main challenge identified was to find a balance between application of these principles and available resources, to prevent the planned improvements from jeopardizing report production times and failing to meet decision-makers' needs. The main recommendation was to gradually advance in improving HTA and its link to decision-making by developing appropriate processes for each country, without attempting to impose, in the short term, standards taken from examples at the international level without adequate adaptation to the local context.

QTLs for seed vigor-related traits identified in maize seeds germinated under artificial aging conditions.

Science.gov (United States)

Han, Zanping; Ku, Lixia; Zhang, Zhenzhen; Zhang, Jun; Guo, Shulei; Liu, Haiying; Zhao, Ruifang; Ren, Zhenzhen; Zhang, Liangkun; Su, Huihui; Dong, Lei; Chen, Yanhui

2014-01-01

High seed vigor is important for agricultural production due to the associated potential for increased growth and productivity. However, a better understanding of the underlying molecular mechanisms is required because the genetic basis for seed vigor remains unknown. We used single-nucleotide polymorphism (SNP) markers to map quantitative trait loci (QTLs) for four seed vigor traits in two connected recombinant inbred line (RIL) maize populations under four treatment conditions during seed germination. Sixty-five QTLs distributed between the two populations were identified and a meta-analysis was used to integrate genetic maps. Sixty-one initially identified QTLs were integrated into 18 meta-QTLs (mQTLs). Initial QTLs with contribution to phenotypic variation values of R(2)>10% were integrated into mQTLs. Twenty-three candidate genes for association with seed vigor traits coincided with 13 mQTLs. The candidate genes had functions in the glycolytic pathway and in protein metabolism. QTLs with major effects (R(2)>10%) were identified under at least one treatment condition for mQTL2, mQTL3-2, and mQTL3-4. Candidate genes included a calcium-dependent protein kinase gene (302810918) involved in signal transduction that mapped in the mQTL3-2 interval associated with germination energy (GE) and germination percentage (GP), and an hsp20/alpha crystallin family protein gene (At5g51440) that mapped in the mQTL3-4 interval associated with GE and GP. Two initial QTLs with a major effect under at least two treatment conditions were identified for mQTL5-2. A cucumisin-like Ser protease gene (At5g67360) mapped in the mQTL5-2 interval associated with GP. The chromosome regions for mQTL2, mQTL3-2, mQTL3-4, and mQTL5-2 may be hot spots for QTLs related to seed vigor traits. The mQTLs and candidate genes identified in this study provide valuable information for the identification of additional quantitative trait genes.

QTLs for seed vigor-related traits identified in maize seeds germinated under artificial aging conditions.

Directory of Open Access Journals (Sweden)

Zanping Han

Full Text Available High seed vigor is important for agricultural production due to the associated potential for increased growth and productivity. However, a better understanding of the underlying molecular mechanisms is required because the genetic basis for seed vigor remains unknown. We used single-nucleotide polymorphism (SNP markers to map quantitative trait loci (QTLs for four seed vigor traits in two connected recombinant inbred line (RIL maize populations under four treatment conditions during seed germination. Sixty-five QTLs distributed between the two populations were identified and a meta-analysis was used to integrate genetic maps. Sixty-one initially identified QTLs were integrated into 18 meta-QTLs (mQTLs. Initial QTLs with contribution to phenotypic variation values of R(2>10% were integrated into mQTLs. Twenty-three candidate genes for association with seed vigor traits coincided with 13 mQTLs. The candidate genes had functions in the glycolytic pathway and in protein metabolism. QTLs with major effects (R(2>10% were identified under at least one treatment condition for mQTL2, mQTL3-2, and mQTL3-4. Candidate genes included a calcium-dependent protein kinase gene (302810918 involved in signal transduction that mapped in the mQTL3-2 interval associated with germination energy (GE and germination percentage (GP, and an hsp20/alpha crystallin family protein gene (At5g51440 that mapped in the mQTL3-4 interval associated with GE and GP. Two initial QTLs with a major effect under at least two treatment conditions were identified for mQTL5-2. A cucumisin-like Ser protease gene (At5g67360 mapped in the mQTL5-2 interval associated with GP. The chromosome regions for mQTL2, mQTL3-2, mQTL3-4, and mQTL5-2 may be hot spots for QTLs related to seed vigor traits. The mQTLs and candidate genes identified in this study provide valuable information for the identification of additional quantitative trait genes.

Principles of Workplace Democracy: Cases from The Czech Republic

Directory of Open Access Journals (Sweden)

Vopalecký Andy

2017-06-01

Full Text Available The article is about the concept of management of democratic companies in the Czech Republic with a focus on the principles of workplace democracy. The analysis is based on four case studies of democratic companies. The case studies have been drawn up on the basis of a questionnaire survey among the workers of companies and interviews with their executives. The research has shown the importance of even a high rate of implementation of the various principles in all surveyed companies. The best rated principle is “dialogue and listening”. In the case of the principle of “reflection and assessment”, it will show certain deficiencies in the provision of feedback. Principles of workplace democracy identified in interviews mostly agree with the principles referred to in the literature. Resulting from the research, it proposes recommendations and suggestions for further research.

Monolayer Boron Nitride Substrate Interactions with Graphene Under In-Plane and Perpendicular Strains: A First-Principles Study

Science.gov (United States)

Behzad, Somayeh

2018-04-01

Effects of strain on the electronic and optical properties of graphene on monolayer boron nitride (BN) substrate are investigated using first-principle calculations based on density functional theory. Strain-free graphene/BN has a small band gap of 97 meV at the K point. The magnitude of band gap increases with in-plane biaxial strain while it decreases with the perpendicular uniaxial strain. The ɛ2 (ω ) spectrum of graphene/BN bilayer for parallel polarization shows red and blue shifts by applying the in-plane tensile and compressive strains, respectively. Also the positions of peaks in the ɛ2 (ω ) spectrum are not significantly changed under perpendicular strain. The calculated results indicate that graphene on the BN substrate has great potential in microelectronic and optoelectronic applications.

The principle of equality of arms in international criminal proceedings

NARCIS (Netherlands)

Fedorova, M.I.

2012-01-01

This book studies the interpretation and application of the principle of equality of arms in proceedings before several international criminal courts. The coming of age of these institutions merits an evaluation of the application of one of the fundamental principles underlying a criminal procedure.

Elastic properties and electronic structure of WS{sub 2} under pressure from first-principles calculations

Energy Technology Data Exchange (ETDEWEB)

Li, Li [Sichuan Univ., Chengdu (China). Inst. of Atomic and Molecular Physics; Civil Aviation Flight Univ. of China, Guanghan (China). Dept. of Physics; Zeng, Zhao-Yi [Chongqing Normal Univ., Chongqing (China). College of Physics and Electronic Engineering; Liang, Ting; Tang, Mei; Cheng, Yan [Sichuan Univ., Chengdu (China). Inst. of Atomic and Molecular Physics

2017-07-01

The influence of pressure on the elastic and mechanical properties of the hexagonal transition-metal dichalcogenide WS{sub 2} is investigated using the first-principles calculations. With the increase in pressure, the lattice parameters and the volume of WS{sub 2} decrease, which is exactly in agreement with the available experimental data and other calculated results. The elastic constants C{sub ij}, bulk modulus B, shear modulus G, Young's modulus E, and Poisson's ratio σ of WS{sub 2} also increase with pressure. At last, for the first time, the band gaps of energy, the partial density of states, and the total density of states under three different pressures are obtained and analysed. It is found that the band gap of WS{sub 2} decreases from 0.843 to 0 eV when the external pressure varies from 0 to 20 GPa, which implies that WS{sub 2} may transform from semiconductors to semimetal phase at a pressure about 20 GPa.

Contemporary treatment principles for early rheumatoid arthritis: a consensus statement.

Science.gov (United States)

Kiely, Patrick D W; Brown, Andrew K; Edwards, Christopher J; O'Reilly, David T; Ostör, Andrew J K; Quinn, Mark; Taggart, Allister; Taylor, Peter C; Wakefield, Richard J; Conaghan, Philip G

2009-07-01

RA has a substantial impact on both patients and healthcare systems. Our objective is to advance the understanding of modern management principles in light of recent evidence concerning the condition's diagnosis and treatment. A group of practicing UK rheumatologists formulated contemporary management principles and clinical practice recommendations concerning both diagnosis and treatment. Areas of clinical uncertainty were documented, leading to research recommendations. A fundamental concept governing treatment of RA is minimization of cumulative inflammation, referred to as the inflammation-time area under the curve (AUC). To achieve this, four core principles of management were identified: (i) detect and refer patients early, even if the diagnosis is uncertain: patients should be referred at the first suspicion of persistent inflammatory polyarthritis and rheumatology departments should provide rapid access to a diagnostic and prognostic service; (ii) treat RA immediately: optimizing outcomes with conventional DMARDs and biologics requires that effective treatment be started early-ideally within 3 months of symptom onset; (iii) tight control of inflammation in RA improves outcome: frequent assessments and an objective protocol should be used to make treatment changes that maintain low-disease activity/remission at an agreed target; (iv) consider the risk-benefit ratio and tailor treatment to each patient: differing patient, disease and drug characteristics require long-term monitoring of risks and benefits with adaptations of treatments to suit individual circumstances. These principles focus on effective control of the inflammatory process in RA, but optimal uptake may require changes in service provision to accommodate appropriate care pathways.

Risk measurement with equivalent utility principles

NARCIS (Netherlands)

Denuit, M.; Dhaene, J.; Goovaerts, M.; Kaas, R.; Laeven, R.

2006-01-01

Risk measures have been studied for several decades in the actuarial literature, where they appeared under the guise of premium calculation principles. Risk measures and properties that risk measures should satisfy have recently received considerable attention in the financial mathematics

Modeling Electric Discharges with Entropy Production Rate Principles

Directory of Open Access Journals (Sweden)

Thomas Christen

2009-12-01

Full Text Available Under which circumstances are variational principles based on entropy production rate useful tools for modeling steady states of electric (gas discharge systems far from equilibrium? It is first shown how various different approaches, as Steenbeck’s minimum voltage and Prigogine’s minimum entropy production rate principles are related to the maximum entropy production rate principle (MEPP. Secondly, three typical examples are discussed, which provide a certain insight in the structure of the models that are candidates for MEPP application. It is then thirdly argued that MEPP, although not being an exact physical law, may provide reasonable model parameter estimates, provided the constraints contain the relevant (nonlinear physical effects and the parameters to be determined are related to disregarded weak constraints that affect mainly global entropy production. Finally, it is additionally conjectured that a further reason for the success of MEPP in certain far from equilibrium systems might be based on a hidden linearity of the underlying kinetic equation(s.

Identifying the Principles of Traditional Iranian Architecture in the Light of Vastu Shastra, the Traditional Indian Wisdom

Directory of Open Access Journals (Sweden)

Ali Goodarzi

2014-06-01

Full Text Available Traditional Iranian houses have always been recognized as examples of 'good-design' in the context of Iranian Architecture according to many scholars. It is believed that their creation has been influenced by the systems of beliefs in the traditional Iranian society; an established system closely followed in their design process which has led to their phenomenal architectural design. The traditional houses of Kashan are excellent examples of such which have often been described as the finest examples of Traditional Iranian houses. However insufficient documentation of the design process of these architectural masterpieces has led to disputes among scholars in determining the exacct architectural system, behind their creation. The effect therefore is not only the inability in creating houses with the same quality in current architectural societies of Iran, but also their decay due to lack of attention and preservation. Historical studies point towards an influence of Indian Architectural system, Vastu Shastra, on the creation of traditional Iranian houses, which appears to be the earlier practice of house design within the Indo-Aryan communities. Using Vastu Shastra as a framework, the objective is to conduct case studies on 22 traditional houses of Kashan to identify the existence of a similar well-established system in Iran based on which all the traditional houses have been designed, and further to introduce it as the traditional architectural system in Iran. In this way the principles of traditional houses of Kashan can be identified in the light of Vastu Shastra, the traditional Indian wisdom.

A Maximum Principle for SDEs of Mean-Field Type

Energy Technology Data Exchange (ETDEWEB)

Andersson, Daniel, E-mail: danieand@math.kth.se; Djehiche, Boualem, E-mail: boualem@math.kth.se [Royal Institute of Technology, Department of Mathematics (Sweden)

2011-06-15

We study the optimal control of a stochastic differential equation (SDE) of mean-field type, where the coefficients are allowed to depend on some functional of the law as well as the state of the process. Moreover the cost functional is also of mean-field type, which makes the control problem time inconsistent in the sense that the Bellman optimality principle does not hold. Under the assumption of a convex action space a maximum principle of local form is derived, specifying the necessary conditions for optimality. These are also shown to be sufficient under additional assumptions. This maximum principle differs from the classical one, where the adjoint equation is a linear backward SDE, since here the adjoint equation turns out to be a linear mean-field backward SDE. As an illustration, we apply the result to the mean-variance portfolio selection problem.

A Maximum Principle for SDEs of Mean-Field Type

International Nuclear Information System (INIS)

Andersson, Daniel; Djehiche, Boualem

2011-01-01

We study the optimal control of a stochastic differential equation (SDE) of mean-field type, where the coefficients are allowed to depend on some functional of the law as well as the state of the process. Moreover the cost functional is also of mean-field type, which makes the control problem time inconsistent in the sense that the Bellman optimality principle does not hold. Under the assumption of a convex action space a maximum principle of local form is derived, specifying the necessary conditions for optimality. These are also shown to be sufficient under additional assumptions. This maximum principle differs from the classical one, where the adjoint equation is a linear backward SDE, since here the adjoint equation turns out to be a linear mean-field backward SDE. As an illustration, we apply the result to the mean-variance portfolio selection problem.

Ion exchange : principles and applications

International Nuclear Information System (INIS)

Bank, Nader; Majumdar, A.S.

1975-01-01

An attempt is made to provide a brief state-of-the-art review of the basic principles underlying the unit operation of ion exchange and its numerous and diverse commercial applications. A selective bibliography is provided for the benefit of the reader interested in pursuing any specific aspect of ion exchange. (author)

Basic principles

International Nuclear Information System (INIS)

Wilson, P.D.

1996-01-01

Some basic explanations are given of the principles underlying the nuclear fuel cycle, starting with the physics of atomic and nuclear structure and continuing with nuclear energy and reactors, fuel and waste management and finally a discussion of economics and the future. An important aspect of the fuel cycle concerns the possibility of ''closing the back end'' i.e. reprocessing the waste or unused fuel in order to re-use it in reactors of various kinds. The alternative, the ''oncethrough'' cycle, discards the discharged fuel completely. An interim measure involves the prolonged storage of highly radioactive waste fuel. (UK)

When not every response to climate change is a good one: identifying principles for sustainable adaptation

CSIR Research Space (South Africa)

Eriksen, S

2011-01-01

Full Text Available to the need for sustainable adaptation strategies and measures that contribute to social justice and environmental integrity. This paper presents four normative principles to guide responses to climate change and illustrates the significance...

J/ψ+χcJ production at the B factories under the principle of maximum conformality

International Nuclear Information System (INIS)

Wang, Sheng-Quan; Wu, Xing-Gang; Zheng, Xu-Chang; Shen, Jian-Ming; Zhang, Qiong-Lian

2013-01-01

Under the conventional scale setting, the renormalization scale uncertainty usually constitutes a systematic error for a fixed-order perturbative QCD estimation. The recently suggested principle of maximum conformality (PMC) provides a principle to eliminate such scale ambiguity in a step-by-step way. Using the PMC, all non-conformal terms in perturbative expansion series are summed into the running coupling, and one obtains a unique, scale-fixed, scheme-independent prediction at any finite order. In the paper, we make a detailed PMC analysis for both the polarized and the unpolarized cross sections for the double charmonium production process, e + +e − →J/ψ(ψ ′ )+χ cJ with (J=0,1,2). The running behavior for the coupling constant, governed by the PMC scales, are determined exactly for the specific processes. We compare our predictions with the measurements at the B factories, BaBar and Belle, and the theoretical estimations obtained in the literature. Because the non-conformal terms are different for various polarized and unpolarized cross sections, the PMC scales of these cross sections are different in principle. It is found that all the PMC scales are almost independent of the initial choice of renormalization scale. Thus, the large renormalization scale uncertainty usually adopted in the literature up to ∼40% at the NLO level, obtained from the conventional scale setting, for both the polarized and the unpolarized cross sections are greatly suppressed. It is found that the charmonium production is dominated by J=0 channel. After PMC scale setting, we obtain σ(J/ψ+χ c0 )=12.25 −3.13 +3.70 fb and σ(ψ ′ +χ c0 )=5.23 −1.32 +1.56 fb, where the squared average errors are caused by bound state parameters as m c , |R J/ψ (0)| and |R χ cJ ′ (0)|, which are non-perturbative error sources in different to the QCD scale setting problem. In comparison to the experimental data, a more accurate theoretical estimation shall be helpful for a precise

Basic safety principles for nuclear power plants

International Nuclear Information System (INIS)

1988-01-01

Nuclear power plant safety requires a continuing quest for excellence. All individuals concerned should constantly be alert to opportunities to reduce risks to the lowest practicable level. The quest, however, is most likely to be fruitful if it is based on an understanding of the underlying objectives and principles of nuclear safety, and the way in which its aspects are interrelated. This report is an attempt to provide a logical framework for such an understanding. The proposed objectives and principles of nuclear safety are interconnected and must be taken as a whole; they do not constitute a menu from which selection can be made. The report takes account of current issues and developments. It includes the concept of safety objectives and the use of probabilistic safety assessment. Reliability targets for safety systems are discussed. The concept of a 'safety culture' is crucial. Attention has been paid to the need for planning for accident management. The report contains objectives and principles. The objectives state what is to be achieved; the principles state how to achieve it. In each case, the basic principle is stated as briefly as possible. The accompanying discussion comments on the reasons for the principle and its importance, as well as exceptions, the extent of coverage and any necessary clarification. The discussion is as important as the principle it augments. 4 figs

First-Principles Studies of Pentaerythritol Tetranitrate (PETN) Single Crystal Unit Cell Volumes and Vibrational Frequencies under Hydrostatic Pressure

Science.gov (United States)

Perger, Warren F.; Zhao, Jijun; Winey, J. M.; Gupta, Y. M.

2006-07-01

The vibrational frequencies of the PETN molecular crystal were calculated using the first-principles CRYSTAL03 program which employs an all-electron LCAO approach and calculates analytic first derivatives of the total energy with respect to atomic displacements. Numerical second derivatives were used to enable calculation of the vibrational frequencies at ambient pressure and under various states of compression. Three different density functionals, B3LYP, PW91, and X3LYP were used to examine the effect of the exchange-correlation functional on the vibrational frequencies. The average deviation with experimental results is shown to be on the order of 2-3%, depending on the functional used. The pressure-induced shift of the vibrational frequencies is presented.

Bernoulli's Principle

Science.gov (United States)

Hewitt, Paul G.

2004-01-01

Some teachers have difficulty understanding Bernoulli's principle particularly when the principle is applied to the aerodynamic lift. Some teachers favor using Newton's laws instead of Bernoulli's principle to explain the physics behind lift. Some also consider Bernoulli's principle too difficult to explain to students and avoid teaching it…

The Principle of the Fermionic Projector: An Approach for Quantum Gravity?

Science.gov (United States)

Finster, Felix

In this short article we introduce the mathematical framework of the principle of the fermionic projector and set up a variational principle in discrete space-time. The underlying physical principles are discussed. We outline the connection to the continuum theory and state recent results. In the last two sections, we speculate on how it might be possible to describe quantum gravity within this framework.

The meaning of the EPSRC principles of robotics

Science.gov (United States)

Bryson, Joanna J.

2017-04-01

In revisiting the Principles of Robotics (as we do in this special issue), it is important to carefully consider their full meaning - their history, the intentions behind them, and their actual societal impact to date. Here I address first the meaning of the document as a whole, then of its constituent parts. Further, I describe the nature of policy, and use the Principles as a case study to discuss how government and academia can interact in constructing policy. I defend the Principles and their main themes: that commercially manufactured robots should not be responsible parties under the law, and that users should not be deceived about robots' capacities or moral status. This perspective allows for the incorporation of robots immediately into UK society and law - the objective of the Principles. The Principles were not designed for every conceivable robot, but rather serve in part as design specifications for robots to be incorporated as legal products into British society.

First-principles investigation of mechanical and electronic properties of LaAg5 Laves phase under pressure

Institute of Scientific and Technical Information of China (English)

高恩强; 黄福祥; 陈志谦; 王兰兰; 张照超

2016-01-01

The effects of applied pressure on the structural, mechanical, and electronic properties of LaAg5 compound were investi-gated employing the first-principles method based on the density functional theory. The mechanical results demonstrated that bulk modulus, shear modulus and Young’s modulus presented the linearly increasing dependences on the external pressure; theB/G and Poisson’s ratio indicated that LaAg5 compound was a ductile material with central forces in interatomic under pressure from 0 to 40 GPa; the universal anisotropic index was performed to investigate the elastic anisotropic of LaAg5. Additionally, the pressure de-pendence of the density of states and Mulliken charge were also discussed. The bonding characterization in LaAg5 was composed of metallic, covalent and ionic. The metallic component was derived from free-electron transferring from Ag-s and Ag-d to Ag-p, and from La-s to La-d. The ionic component was due to the charge movement from La to Ag. The covalent was owing to Ag-p-La-d bonding hybridization and Ag-s-Ag-p in the Ag atomic chains. The covalent and ionic bonds were stronger under pressure but there was no significant change in metallic nature.

GM Food. Fundamental safety principles

Directory of Open Access Journals (Sweden)

Lorena GALLARDO

2017-08-01

Full Text Available This paper aims to provide a concise exposition of some of the most basic legal principles linked to the process of evaluation of genetically modified food safety, revealing their most salient features and also highlighting the deficiencies that some of them bring along in their application to the products under study.

Using Green Chemistry and Engineering Principles to Design ...

Science.gov (United States)

The concepts of green chemistry and engineering (GC&E) have been promoted as an effective qualitative framework for developing more sustainable chemical syntheses, processes, and material management techniques. This has been demonstrated by many theoretical and practical cases. In addition, there are several approaches and frameworks focused on demonstrating that improvements were achieved through GC&E technologies. However, the application of these principles is not always straightforward. We propose using systematic frameworks and tools that help practitioners when deciding which principles can be applied, the levels of implementation, prospective of obtaining simultaneous improvements in all sustainability aspects, and ways to deal with multiobjective problems. Therefore, this contribution aims to provide a systematic combination of three different and complementary design tools for assisting designers in evaluating, developing, and improving chemical manufacturing and material management systems under GC&E perspectives. The WAR Algorithm, GREENSCOPE, and SustainPro were employed for this synergistic approach of incorporating sustainability at early stages of process development. In this demonstration, simulated ammonia production is used as a case study to illustrate this advancement. Results show how to identify process design areas for improvements, key factors, multi-criteria decision-making solutions, and optimal tradeoffs. Finally, conclusions were pre

78 FR 47154 - Core Principles and Other Requirements for Swap Execution Facilities; Correction

Science.gov (United States)

2013-08-05

... COMMODITY FUTURES TRADING COMMISSION 17 CFR Part 37 RIN 3038-AD18 Core Principles and Other Requirements for Swap Execution Facilities; Correction AGENCY: Commodity Futures Trading Commission. ACTION... Principles [Corrected] 2. On page 33600, in the second column, under the heading Core Principle 3 of Section...

Foundational Concepts and Underlying Theories for Majors in "Biochemistry and Molecular Biology"

Science.gov (United States)

Tansey, John T.; Baird, Teaster, Jr.; Cox, Michael M.; Fox, Kristin M.; Knight, Jennifer; Sears, Duane; Bell, Ellis

2013-01-01

Over the past two years, through an NSF RCN UBE grant, the ASBMB has held regional workshops for faculty members and science educators from around the country that focused on identifying: 1) core principles of biochemistry and molecular biology, 2) essential concepts and underlying theories from physics, chemistry, and mathematics, and 3)…

Design principles of metal-cutting machine tools

CERN Document Server

Koenigsberger, F

1964-01-01

Design Principles of Metal-Cutting Machine Tools discusses the fundamentals aspects of machine tool design. The book covers the design consideration of metal-cutting machine, such as static and dynamic stiffness, operational speeds, gearboxes, manual, and automatic control. The text first details the data calculation and the general requirements of the machine tool. Next, the book discusses the design principles, which include stiffness and rigidity of the separate constructional elements and their combined behavior under load, as well as electrical, mechanical, and hydraulic drives for the op

The Principle of Social Scaling

Directory of Open Access Journals (Sweden)

Paulo L. dos Santos

2017-01-01

Full Text Available This paper identifies a general class of economic processes capable of generating the first-moment constraints implicit in the observed cross-sectional distributions of a number of economic variables: processes of social scaling. Across a variety of settings, the outcomes of economic competition reflect the normalization of individual values of certain economic quantities by average or social measures of themselves. The resulting socioreferential processes establish systematic interdependences among individual values of important economic variables, which under certain conditions take the form of emergent first-moment constraints on their distributions. The paper postulates a principle describing this systemic regulation of socially scaled variables and illustrates its empirical purchase by showing how capital- and labor-market competition can give rise to patterns of social scaling that help account for the observed distributions of Tobin’s q and wage income. The paper’s discussion embodies a distinctive approach to understanding and investigating empirically the relationship between individual agency and structural determinations in complex economic systems and motivates the development of observational foundations for aggregative, macrolevel economic analysis.

First-principles calculations of structural, elastic, and electronic properties of trigonal ZnSnO{sub 3} under pressure

Energy Technology Data Exchange (ETDEWEB)

Liu, Qi-Jun, E-mail: qijunliu@home.swjtu.edu.cn [School of Physical Science and Technology, Southwest Jiaotong University, Key Laboratory of Advanced Technologies of Materials, Ministry of Education of China, Chengdu 610031 (China); Bond and Band Engineering Group, Sichuan Provincial Key Laboratory (for Universities) of High Pressure Science and Technology, Southwest Jiaotong University, Chengdu 610031 (China); Qin, Han; Jiao, Zhen; Liu, Fu-Sheng [School of Physical Science and Technology, Southwest Jiaotong University, Key Laboratory of Advanced Technologies of Materials, Ministry of Education of China, Chengdu 610031 (China); Bond and Band Engineering Group, Sichuan Provincial Key Laboratory (for Universities) of High Pressure Science and Technology, Southwest Jiaotong University, Chengdu 610031 (China); Liu, Zheng-Tang [State Key Laboratory of Solidification Processing, Northwestern Polytechnical University, Xi’an 710072 (China)

2016-09-01

First-principles calculations of the structural, elastic, mechanical and electronic properties of ilmenite-type ZnSnO{sub 3} under pressure have been investigated in the present paper. Our calculated lattice constants at zero pressure are in agreement with the published theoretical and experimental data. The elastic constants at zero and high pressure have been obtained, which are used to discuss the mechanical stability of ilmenite-type ZnSnO{sub 3}. The mechanical properties such as bulk modulus, shear modulus, Young’s modulus and Poisson’s ratio under pressure have been studied. Electronic properties show that ilmenite-type ZnSnO{sub 3} is shown to be a direct bandgap of 1.063 (GGA-PW91)/3.977 (PBE0) eV. The bandgap increases with the increasing pressure. Moreover, the partial density of states has been analyzed to explain the increased bandgap. - Highlights: • Physical properties of ilmenite-type ZnSnO{sub 3} under pressure have been investigated. • Ilmenite-type ZnSnO{sub 3} behaves in a ductile manner. • Ilmenite-type ZnSnO{sub 3} is a direct bandgap compound with 3.977 eV. • Bandgap of Ilmenite-type ZnSnO{sub 3} increases with the increasing pressure.

The precautionary principle in environmental regulations for drinking water

International Nuclear Information System (INIS)

Crawford-Brown, Douglas; Crawford-Brown, Sean

2011-01-01

The precautionary principle has been proposed as a means of providing increased safety for consumers of drinking water. While the principle has received increased attention over the past 2 decades, it remains rather poorly defined both in law and practice. Hence, the implications for application in risk-based decisions on water quality are not fully developed. This paper examines a series of philosophical, practical and decision-theoretic issues related to the application of the principle in such decisions, highlighting areas where at least the intent of the principle is already well embedded in environmental regulation through margins of safety, and identifying residual issues. A conclusion is drawn that full application of the principle may be driven forward both by programmes such as REACH in the EU, and by the emerging Water Framework Directive and multi-stakeholder approaches to climate change mitigation and adaptation.

First-principles study on the phase transition, elastic properties and electronic structure of Pt3Al alloys under high pressure

International Nuclear Information System (INIS)

Liu, Yanjun; Huang, Huawei; Pan, Yong; Zhao, Guanghui; Liang, Zheng

2014-01-01

Highlights: • The phase transition of Pt 3 Al alloys occurs at 60 GPa. • The elastic modulus of Pt 3 Al alloys increase with increasing pressure. • The cubic structure has good resistance to volume deformation under high pressure. • The pressure enhances the hybridization between Pt atom and Al atom. - Abstract: The phase transition, formation enthalpies, elastic properties and electronic structure of Pt 3 Al alloys are studied using first-principle approach. The calculated results show that the pressure leads to phase transition from tetragonal structure to cubic structure at 60 GPa. With increasing pressure, the elastic constants, bulk modulus and shear modulus of these Pt 3 Al alloys increase linearly and the bond lengths of Pt–Al metallic bonds and the peak at E F decrease. The cubic Pt 3 Al alloy has excellent resistance to volume deformation under high pressure. We suggest that the phase transition is derived from the hybridization between Pt and Al atoms for cubic structure is stronger than that of tetragonal structure and forms the strong Pt–Al metallic bonds under high pressure

The Obstacle Version of the Geometric Dynamic Programming Principle: Application to the Pricing of American Options Under Constraints

International Nuclear Information System (INIS)

Bouchard, Bruno; Vu, Thanh Nam

2010-01-01

We provide an obstacle version of the Geometric Dynamic Programming Principle of Soner and Touzi (J. Eur. Math. Soc. 4:201-236, 2002) for stochastic target problems. This opens the doors to a wide range of applications, particularly in risk control in finance and insurance, in which a controlled stochastic process has to be maintained in a given set on a time interval [0,T]. As an example of application, we show how it can be used to provide a viscosity characterization of the super-hedging cost of American options under portfolio constraints, without appealing to the standard dual formulation from mathematical finance. In particular, we allow for a degenerate volatility, a case which does not seem to have been studied so far in this context.

41 CFR Appendix A to Subpart C of... - 3-Key Points and Principles

Science.gov (United States)

2010-07-01

... Principles A Appendix A to Subpart C of Part 102 Public Contracts and Property Management Federal Property... 102-3—Key Points and Principles This appendix provides additional guidance in the form of answers to frequently asked questions and identifies key points and principles that may be applied to situations not...

Code of ethics: principles for ethical leadership.

Science.gov (United States)

Flite, Cathy A; Harman, Laurinda B

2013-01-01

The code of ethics for a professional association incorporates values, principles, and professional standards. A review and comparative analysis of a 1934 pledge and codes of ethics from 1957, 1977, 1988, 1998, 2004, and 2011 for a health information management association was conducted. Highlights of some changes in the healthcare delivery system are identified as a general context for the codes of ethics. The codes of ethics are examined in terms of professional values and changes in the language used to express the principles of the various codes.

Accelerating RCRA corrective action: The principles of the DOE approach

International Nuclear Information System (INIS)

Kimmell, T.A.; Green, D.R.; Ranek, N.L.; Coalgate, J.L.

1995-01-01

The US Department of Energy (DOE) is involved in the remediation of environmental contamination at many of its facilities under the Resource Conservation and Recovery Act (RCRA). RCRA's corrective action provisions were established by the Hazardous and Solid Waste Amendments of 1984 (HSWA). In response to the HSWA mandate, EPA established a program for the conduct of RCRA corrective action that was similar to that established under the Comprehensive Environmental Response Compensation and Liability Act (CERCLA). In addition, EPA developed and implemented its ''stabilization'' initiative as a means of quickly addressing immediate risks posed by releases until long term solutions can be applied. To improve the efficiency of environmental restoration at its facilities, DOE is developing guidance and training programs on accelerated environmental restoration under RCRA. A RCRA guidance document, entitled ''Accelerating RCRA Corrective Action at DOE Facilities,'' is currently being developed by DOE's Office of Environmental Policy and Assistance. The new guidance document will outline a decision-making process for determining if acceleration is appropriate for individual facilities, for identifying, evaluating, and selecting options for program acceleration, and for implementing selected acceleration options. The document will also discuss management and planning strategies that provide a firm foundation for accelerating RCRA corrective action. These strategies include a number of very basic principles that have proven effective at DOE and other federal facilities, as well as some new approaches. The purpose of this paper is to introduce DOE's new guidance document, discuss the general approach presented in the guidance for accelerating RCRA corrective action, and to emphasize some of the more important principles of effective management and planning

Extended Huygens-Fresnel principle and optical waves propagation in turbulence: discussion.

Science.gov (United States)

Charnotskii, Mikhail

2015-07-01

Extended Huygens-Fresnel principle (EHF) currently is the most common technique used in theoretical studies of the optical propagation in turbulence. A recent review paper [J. Opt. Soc. Am. A31, 2038 (2014)JOAOD60740-323210.1364/JOSAA.31.002038] cites several dozens of papers that are exclusively based on the EHF principle. We revisit the foundations of the EHF, and show that it is burdened by very restrictive assumptions that make it valid only under weak scintillation conditions. We compare the EHF to the less-restrictive Markov approximation and show that both theories deliver identical results for the second moment of the field, rendering the EHF essentially worthless. For the fourth moment of the field, the EHF principle is accurate under weak scintillation conditions, but is known to provide erroneous results for strong scintillation conditions. In addition, since the EHF does not obey the energy conservation principle, its results cannot be accurate for scintillations of partially coherent beam waves.

41 CFR Appendix A to Subpart D of... - 3-Key Points and Principles

Science.gov (United States)

2010-07-01

... Principles A Appendix A to Subpart D of Part 102 Public Contracts and Property Management Federal Property... Subpart D of Part 102-3—Key Points and Principles This appendix provides additional guidance in the form of answers to frequently asked questions and identifies key points and principles that may be applied...

Legal principles of regulatory administration and nuclear safety regulation

Energy Technology Data Exchange (ETDEWEB)

Lee, Kyeong Hui; Cheong, Sang Kee [Hannam Univ., Taejon (Korea, Republic of)

2000-12-15

This research presents a critical analysis and evaluation of principles of administrative laws in order to provide framework of structural reform on the nuclear safety regulation system. The focus of this analysis and evaluation is centered around the area of origin of regulatory administrative laws; authorities of regulation; procedures of regulatory actions; regulatory enforcement; and administrative relief system. In chapter 2 the concept of regulatory administration is analysed. Chapter 3 identifies the origin of regulatory administration and the principles of administration laws. It also examines legal nature of the nuclear safety standard. In relation to regulatory authorities. Chapter 4 identifies role and responsibility of administration authorities and institutions. It also examines fundamental principles of delegation of power. Then the chapter discusses the nuclear safety regulation authorities and their roles and responsibilities. Chapter 5 classifies and examines regulatory administration actions. Chapter 6 evaluates enforcement measure for effectiveness of regulation. Finally, chapter 7 discusses the administrative relief system for reviewing unreasonable regulatory acts.

Sustainable development and the nature of environmental legal principles

Directory of Open Access Journals (Sweden)

J Verschuuren

2006-05-01

Full Text Available In this article, “things” lawyers call “principles” of environmental law will be discussed from a theoretical perspective. Three fundamental questions are answered: 1. Where does the high moral value that is usually attributed principles come from? 2. What is the exact difference between a principle and a legal rule, and between a principle and a policy? 3. What is the relationship between a principle and more concrete legal rules and policies? It is argued that principles of environmental law receive their high moral value from the ideal of sustainable development. An ideal is a value that is explicit, implicit or latent in the law, or the public and moral culture of a society or group that usually cannot be fully realised, and that partly transcends contingent, historical formulations, and implementations in terms of rules and principles. Principles form a necessary link between directly applicable and enforceable environmental legal rules and the underlying ideal. They are a necessary medium for ideals to find their way into concrete rules and can be used to bridge the gap between the morality of duty and the morality of aspiration. Because of their basis in (written or unwritten law and their possible direct and intense influence on legal rules concerning activities that may harm the environment, they must be placed within the morality of duty: a bridgehead within the morality of duty reaching out for the morality of aspiration. From the general function of principles of forming a beachhead in the morality of duty, nine more concrete functions can be derived. These functions principles, both of a substantive and of a procedural nature, have, make it possible to distinguish them from legal rules. It must be acknowledged, however, that there is no very strict separation between principles on one side and rules on the other: environmental norms can be placed on a sliding scale with rules on one side and principles on the other side

Uncertainty, joint uncertainty, and the quantum uncertainty principle

International Nuclear Information System (INIS)

Narasimhachar, Varun; Poostindouz, Alireza; Gour, Gilad

2016-01-01

Historically, the element of uncertainty in quantum mechanics has been expressed through mathematical identities called uncertainty relations, a great many of which continue to be discovered. These relations use diverse measures to quantify uncertainty (and joint uncertainty). In this paper we use operational information-theoretic principles to identify the common essence of all such measures, thereby defining measure-independent notions of uncertainty and joint uncertainty. We find that most existing entropic uncertainty relations use measures of joint uncertainty that yield themselves to a small class of operational interpretations. Our notion relaxes this restriction, revealing previously unexplored joint uncertainty measures. To illustrate the utility of our formalism, we derive an uncertainty relation based on one such new measure. We also use our formalism to gain insight into the conditions under which measure-independent uncertainty relations can be found. (paper)

Gauge principle for hyper(para) fields

Energy Technology Data Exchange (ETDEWEB)

Govorkov, A.B. (Joint Inst. for Nuclear Research, Dubna (USSR))

1983-04-01

A special representation for parafields is considered which is based on the use of the Clifford hypernumbers. The principle of gauge invariance under hypercomplex phase transformations of parafields is formulated. A special role of quaternion hyperfields and corresponding Yang-Mills lagrangian with the gauge SO(3)-symmetry is pointed out.

Canadian nuclear power principles for beyond design basis events - supporting rationale

International Nuclear Information System (INIS)

Elliott, M.; Newman, G.; Bhaloo, A.

2014-01-01

The development of the following principles and their rationale began during a special Chief Nuclear Engineers forum held on March 25th, 2013 in Toronto. These principles are intended to provide guidance to the Canadian Nuclear Power Industry in developing responses to the lessons learned from the Fukushima event of March 2011. These principles were accepted and signed off by the Chief Nuclear Officers of each of the three utilities in August 2013 and were presented to the CNSC at a public hearing on August 21, 2013. This document provides the underlying rationale for the principles. (author)

Canadian nuclear power principles for beyond design basis events - supporting rationale

Energy Technology Data Exchange (ETDEWEB)

Elliott, M. [OPG Nuclear, Ontario (Canada); Newman, G. [Bruce Power, Ontario (Canada); Bhaloo, A. [New Brunswick Power, New Brunswick (Canada)

2014-09-15

The development of the following principles and their rationale began during a special Chief Nuclear Engineers forum held on March 25th, 2013 in Toronto. These principles are intended to provide guidance to the Canadian Nuclear Power Industry in developing responses to the lessons learned from the Fukushima event of March 2011. These principles were accepted and signed off by the Chief Nuclear Officers of each of the three utilities in August 2013 and were presented to the CNSC at a public hearing on August 21, 2013. This document provides the underlying rationale for the principles. (author)

Canadian nuclear power principles for beyond design basis events - supporting rationale

Energy Technology Data Exchange (ETDEWEB)

Elliott, M. [Ontario Power Generation Nuclear, Pickering, ON (Canada); Newman, G. [Bruce Power, Tiverton, ON (Canada); Bhaloo, A. [New Brunswick Power, Fredericton, NB (Canada)

2014-07-01

The development of the following principles and their rationale began during a special Chief Nuclear Engineers forum held on March 25th, 2013 in Toronto. These principles are intended to provide guidance to the Canadian Nuclear Power Industry in developing responses to the lessons learned from the Fukushima event of March 2011. These principles were accepted and signed off by the Chief Nuclear Officers of each of the three utilities in August 2013 and were presented to the CNSC at a public hearing on August 21, 2013. This document provides the underlying rationale for the principles. (author)

The gauge principle vs. the equivalence principle

International Nuclear Information System (INIS)

Gates, S.J. Jr.

1984-01-01

Within the context of field theory, it is argued that the role of the equivalence principle may be replaced by the principle of gauge invariance to provide a logical framework for theories of gravitation

Examples of testing global identifiability of biological and biomedical models with the DAISY software.

Science.gov (United States)

Saccomani, Maria Pia; Audoly, Stefania; Bellu, Giuseppina; D'Angiò, Leontina

2010-04-01

DAISY (Differential Algebra for Identifiability of SYstems) is a recently developed computer algebra software tool which can be used to automatically check global identifiability of (linear and) nonlinear dynamic models described by differential equations involving polynomial or rational functions. Global identifiability is a fundamental prerequisite for model identification which is important not only for biological or medical systems but also for many physical and engineering systems derived from first principles. Lack of identifiability implies that the parameter estimation techniques may not fail but any obtained numerical estimates will be meaningless. The software does not require understanding of the underlying mathematical principles and can be used by researchers in applied fields with a minimum of mathematical background. We illustrate the DAISY software by checking the a priori global identifiability of two benchmark nonlinear models taken from the literature. The analysis of these two examples includes comparison with other methods and demonstrates how identifiability analysis is simplified by this tool. Thus we illustrate the identifiability analysis of other two examples, by including discussion of some specific aspects related to the role of observability and knowledge of initial conditions in testing identifiability and to the computational complexity of the software. The main focus of this paper is not on the description of the mathematical background of the algorithm, which has been presented elsewhere, but on illustrating its use and on some of its more interesting features. DAISY is available on the web site http://www.dei.unipd.it/ approximately pia/. 2010 Elsevier Ltd. All rights reserved.

An anti-inflammatory principle from cactus.

Science.gov (United States)

Park, E H; Kahng, J H; Lee, S H; Shin, K H

2001-03-01

In previous studies, the ethanol extract of cactus (Opuntia ficus-indica) showed potent anti-inflammatory action. In the present study, following fractionation of the methanol extract of cactus stems guided by adjuvant-induced chronic inflammation model in mice, an active anti-inflammatory principle has been isolated and identified as beta-sitosterol.

The measure and significance of Bateman's principles.

Science.gov (United States)

Collet, Julie M; Dean, Rebecca F; Worley, Kirsty; Richardson, David S; Pizzari, Tommaso

2014-05-07

Bateman's principles explain sex roles and sexual dimorphism through sex-specific variance in mating success, reproductive success and their relationships within sexes (Bateman gradients). Empirical tests of these principles, however, have come under intense scrutiny. Here, we experimentally show that in replicate groups of red junglefowl, Gallus gallus, mating and reproductive successes were more variable in males than in females, resulting in a steeper male Bateman gradient, consistent with Bateman's principles. However, we use novel quantitative techniques to reveal that current methods typically overestimate Bateman's principles because they (i) infer mating success indirectly from offspring parentage, and thus miss matings that fail to result in fertilization, and (ii) measure Bateman gradients through the univariate regression of reproductive over mating success, without considering the substantial influence of other components of male reproductive success, namely female fecundity and paternity share. We also find a significant female Bateman gradient but show that this likely emerges as spurious consequences of male preference for fecund females, emphasizing the need for experimental approaches to establish the causal relationship between reproductive and mating success. While providing qualitative support for Bateman's principles, our study demonstrates how current approaches can generate a misleading view of sex differences and roles.

A comparative survey of chemistry-driven in silico methods to identify hazardous substances under REACH

NARCIS (Netherlands)

Nendza, M.; Gabbert, S.G.M.; Kühne, R.; Lombardo, A.; Roncaglioni, A.; Benfenati, E.; Benigi, R.; Bossa, C.; Strempel, S.; Scheringer, M.; Fernandez, A.; Rallo, R.; Giralt, F.; Dimitrov, S.; Mekenyan, O.; Bringezu, F.; Schüürmann, G.

2013-01-01

This paper presents an inventory of in silico screening tools to identify substance properties of concern under the European chemicals’ legislation REACH. The objective is to support the selection and implementation of appropriate tools as building blocks within integrated testing strategies (ITS).

On the checking of electric charge conservation law and the pauli principle

International Nuclear Information System (INIS)

Okun', L.B.

1989-01-01

This is a short critical review of the attempts to check the accuracy with which are carried out in experiment the electric charge conservation law and the Pauli principle. The absence of the inwardly noncontradictory phenomenological theory is emphasized, which could describe the charge conservation and/or the Pauli principle violation. Under charge nonconservation longitudinal photons are of a principal importance. New suggestions concerning the principle Puli checking are discussed

Safeguards First Principle Initiative (SFPI) Cost Model

International Nuclear Information System (INIS)

Price, Mary Alice

2010-01-01

The Nevada Test Site (NTS) began operating Material Control and Accountability (MC and A) under the Safeguards First Principle Initiative (SFPI), a risk-based and cost-effective program, in December 2006. The NTS SFPI Comprehensive Assessment of Safeguards Systems (COMPASS) Model is made up of specific elements (MC and A plan, graded safeguards, accounting systems, measurements, containment, surveillance, physical inventories, shipper/receiver differences, assessments/performance tests) and various sub-elements, which are each assigned effectiveness and contribution factors that when weighted and rated reflect the health of the MC and A program. The MC and A Cost Model, using an Excel workbook, calculates budget and/or actual costs using these same elements/sub-elements resulting in total costs and effectiveness costs per element/sub-element. These calculations allow management to identify how costs are distributed for each element/sub-element. The Cost Model, as part of the SFPI program review process, enables management to determine if spending is appropriate for each element/sub-element.

An introduction to heat transfer principles and calculations

CERN Document Server

Ede, A J; Ower, E

1967-01-01

An Introduction to Heat Transfer Principles and Calculations is an introductory text to the principles and calculations of heat transfer. The theory underlying heat transfer is described, and the principal results and formulae are presented. Available techniques for obtaining rapid, approximate solutions to complicated problems are also considered. This book is comprised of 12 chapters and begins with a brief account of some of the concepts, methods, nomenclature, and other relevant information about heat transfer. The reader is then introduced to radiation, conduction, convection, and boiling

Principles of mathematical modeling

CERN Document Server

Dym, Clive

2004-01-01

Science and engineering students depend heavily on concepts of mathematical modeling. In an age where almost everything is done on a computer, author Clive Dym believes that students need to understand and "own" the underlying mathematics that computers are doing on their behalf. His goal for Principles of Mathematical Modeling, Second Edition, is to engage the student reader in developing a foundational understanding of the subject that will serve them well into their careers. The first half of the book begins with a clearly defined set of modeling principles, and then introduces a set of foundational tools including dimensional analysis, scaling techniques, and approximation and validation techniques. The second half demonstrates the latest applications for these tools to a broad variety of subjects, including exponential growth and decay in fields ranging from biology to economics, traffic flow, free and forced vibration of mechanical and other systems, and optimization problems in biology, structures, an...

Overview of the fundamental safety principles

International Nuclear Information System (INIS)

Chishinga, Milton Mulenga

2015-02-01

The primary objective of this work was to provide an overview of the International Atomic Energy (IAEA) document; 'Fundamental Safety principles, SF.1'. The document outlines ten (10) fundamental principles which provide the basis for an effective the radiation protection framework. The document is the topmost in the hierarchy of the IAEA Safety Standards Series. These principles are the foundation of the nuclear safety put stringent obligations on Parties under the Convention on Nuclear Safety. The fundamental safety objective is to protect people and the environment from harmful effects of ionizing radiation. The fundamental Safety objective of protecting people individually and collectively and the environment has to be achieved without unduly limiting the operation of facilities or the conduct of activities that give rise to risks. The thematic areas covered are; responsibility for safety, role of government, leadership and management for safety, justification of facilities and activities, optimization of protection, limitation of risks to individuals, protection of present and future generations, prevention of accidents, emergency preparedness and response and protective actions to reduce existing or unregulated radiation risks. Appropriate recommendations have been provided for effective application of the principles by Governments, Regulatory Bodies and Operating Organizations of facilities and Nuclear Installations the give rise to radiation risks. (au)

Polarization-dependent force driving the Eg mode in bismuth under optical excitation: comparison of first-principles theory with ultra-fast x-ray experiments

Science.gov (United States)

Fahy, Stephen; Murray, Eamonn

2015-03-01

Using first principles electronic structure methods, we calculate the induced force on the Eg (zone centre transverse optical) phonon mode in bismuth immediately after absorption of a ultrafast pulse of polarized light. To compare the results with recent ultra-fast, time-resolved x-ray diffraction experiments, we include the decay of the force due to carrier scattering, as measured in optical Raman scattering experiments, and simulate the optical absorption process, depth-dependent atomic driving forces, and x-ray diffraction in the experimental geometry. We find excellent agreement between the theoretical predictions and the observed oscillations of the x-ray diffraction signal, indicating that first-principles theory of optical absorption is well suited to the calculation of initial atomic driving forces in photo-excited materials following ultrafast excitation. This work is supported by Science Foundation Ireland (Grant No. 12/IA/1601) and EU Commission under the Marie Curie Incoming International Fellowships (Grant No. PIIF-GA-2012-329695).

Principles of Sociology in Systems Engineering

Science.gov (United States)

Watson, Michael D.; Andrews, James G.; Larsen, Jordan A.

2017-01-01

Systems engineering involves both the integration of the system and the integration of the disciplines which develop and operate the system. Integrating the disciplines is a sociological effort to bring together different groups, often with different terminology, to achieve a common goal, the system. The focus for the systems engineer is information flow through the organization, between the disciplines, to ensure the system is developed and operated with all relevant information informing system decisions. Robert K. Merton studied the sociological principles of the sciences and the sociological principles he developed apply to systems engineering. Concepts such as specification of ignorance, common terminology, opportunity structures, role-sets, and the reclama (reconsideration) process are all important sociological approaches that should be employed by the systems engineer. In bringing the disciplines together, the systems engineer must also be wary of social ambivalence, social anomie, social dysfunction, insider-outsider behavior, unintended consequences, and the self-fulfilling prophecy. These sociological principles provide the systems engineer with key approaches to manage the information flow through the organization as the disciplines are integrated and share their information. This also helps identify key sociological barriers to information flow through the organization. This paper will discuss this theoretical basis for the application of sociological principles to systems engineering.

Identifiability of tree-child phylogenetic networks under a probabilistic recombination-mutation model of evolution.

Science.gov (United States)

Francis, Andrew; Moulton, Vincent

2018-06-07

Phylogenetic networks are an extension of phylogenetic trees which are used to represent evolutionary histories in which reticulation events (such as recombination and hybridization) have occurred. A central question for such networks is that of identifiability, which essentially asks under what circumstances can we reliably identify the phylogenetic network that gave rise to the observed data? Recently, identifiability results have appeared for networks relative to a model of sequence evolution that generalizes the standard Markov models used for phylogenetic trees. However, these results are quite limited in terms of the complexity of the networks that are considered. In this paper, by introducing an alternative probabilistic model for evolution along a network that is based on some ground-breaking work by Thatte for pedigrees, we are able to obtain an identifiability result for a much larger class of phylogenetic networks (essentially the class of so-called tree-child networks). To prove our main theorem, we derive some new results for identifying tree-child networks combinatorially, and then adapt some techniques developed by Thatte for pedigrees to show that our combinatorial results imply identifiability in the probabilistic setting. We hope that the introduction of our new model for networks could lead to new approaches to reliably construct phylogenetic networks. Copyright © 2018 Elsevier Ltd. All rights reserved.

Optimality principles in the regulation of metabolic networks.

Science.gov (United States)

Berkhout, Jan; Bruggeman, Frank J; Teusink, Bas

2012-08-29

One of the challenging tasks in systems biology is to understand how molecular networks give rise to emergent functionality and whether universal design principles apply to molecular networks. To achieve this, the biophysical, evolutionary and physiological constraints that act on those networks need to be identified in addition to the characterisation of the molecular components and interactions. Then, the cellular "task" of the network-its function-should be identified. A network contributes to organismal fitness through its function. The premise is that the same functions are often implemented in different organisms by the same type of network; hence, the concept of design principles. In biology, due to the strong forces of selective pressure and natural selection, network functions can often be understood as the outcome of fitness optimisation. The hypothesis of fitness optimisation to understand the design of a network has proven to be a powerful strategy. Here, we outline the use of several optimisation principles applied to biological networks, with an emphasis on metabolic regulatory networks. We discuss the different objective functions and constraints that are considered and the kind of understanding that they provide.

Optimality Principles in the Regulation of Metabolic Networks

Directory of Open Access Journals (Sweden)

Jan Berkhout

2012-08-01

Full Text Available One of the challenging tasks in systems biology is to understand how molecular networks give rise to emergent functionality and whether universal design principles apply to molecular networks. To achieve this, the biophysical, evolutionary and physiological constraints that act on those networks need to be identified in addition to the characterisation of the molecular components and interactions. Then, the cellular “task” of the network—its function—should be identified. A network contributes to organismal fitness through its function. The premise is that the same functions are often implemented in different organisms by the same type of network; hence, the concept of design principles. In biology, due to the strong forces of selective pressure and natural selection, network functions can often be understood as the outcome of fitness optimisation. The hypothesis of fitness optimisation to understand the design of a network has proven to be a powerful strategy. Here, we outline the use of several optimisation principles applied to biological networks, with an emphasis on metabolic regulatory networks. We discuss the different objective functions and constraints that are considered and the kind of understanding that they provide.

Mach's principle in spatially homogeneous spacetimes

International Nuclear Information System (INIS)

Tipler, F.J.

1978-01-01

On the basis of Mach's Principle it is concluded that the only singularity-free solution to the empty space Einstein equations is flat space. It is shown that the only singularity-free solution to the empty space Einstein equations which is spatially homogeneous and globally hyperbolic is in fact suitably identified Minkowski space. (Auth.)

EcoPrinciples Connect: A Pilot Project Matching Ecological Principles with Available Data to Promote Ecosystem-Based Management

Science.gov (United States)

Martone, R. G.; Erickson, A.; Mach, M.; Hale, T.; McGregor, A.; Prahler, E. E.; Foley, M.; Caldwell, M.; Hartge, E. H.

2016-12-01

Ocean and coastal practitioners work within existing financial constraints, jurisdictions, and legislative authorities to manage coastal and marine resources while seeking to promote and maintain a healthy and productive coastal economy. Fulfilling this mandate necessitates incorporation of best available science, including ecosystem-based management (EBM) into coastal and ocean management decisions. To do this, many agencies seek ways to apply lessons from ecological theory into their decision processes. However, making direct connections between science and management can be challenging, in part because there is no process for linking ecological principles (e.g., maintaining species diversity, habitat diversity, connectivity and populations of key species) with available data. Here we explore how incorporating emerging data and methods into resource management at a local scale can improve the overall health of our coastal and marine ecosystems. We introduce a new web-based interface, EcoPrinciples Connect, that links marine managers to scientific and geospatial information through the lens of these ecological principles, ultimately helping managers become more efficient, more consistent, and advance the integration of EBM. The EcoPrinciples Connect tool grew directly out of needs identified in response to a Center for Ocean Solutions reference guide, Incorporating Ecological Principles into California Ocean and Coastal Management: Examples from Practice. Here we illustrate how we have worked to translate the information in this guide into a co-developed, user-centric tool for agency staff. Specifically, we present a pilot project where we match publicly available data to the ecological principles for the California San Francisco Bay Conservation and Development Commission. We will share early lessons learned from pilot development and highlight opportunities for future transferability to an expanded group of practitioners.

Identifying intelligent Building Management Systems (BMS) in ...

African Journals Online (AJOL)

Identifying intelligent Building Management Systems (BMS) in sustainable housing. ... Journal of Fundamental and Applied Sciences ... attention to the principles of sustainability of energy and organized approach to sustainable development.

Investigation of gamma-ray fingerprint identifying mechanism for the types of radiation sources

CERN Document Server

Liu Su Ping; Gu Dang Chang; Gong-Jian; Hao Fan Hua; Hu Guang Chun

2002-01-01

Radiation fingerprints sometimes can be used to label and identify the radiation resources. For instance, in a future nuclear reduction treaty that requires verification of irreversible dismantling of reduced nuclear warheads, the radiation fingerprints of nuclear warheads are expected to play a key role in labelling and identifying the reduced warheads. It would promote the development of nuclear warheads deep-cuts verification technologies if authors start right now some investigations on the issues related to the radiation fingerprints. The author dedicated to the investigation of gamma-ray fingerprint identifying mechanism for the types of radiation resources. The purpose of the identifying mechanism investigation is to find a credible way to tell whether any two gamma-ray spectral fingerprints that are under comparison are radiated from the same resource. The authors created the spectrum pattern comparison (SPC) to study the comparability of the two radiation fingerprints. Guided by the principle of SPC,...

Principles and Practices of EU External Representation.

NARCIS (Netherlands)

Blockmans, S.; Wessel, Ramses A.

2012-01-01

With this working paper, CLEER aims to offer a better insight into selected legal aspects concerning the European Union’s redefined diplomatic persona. In particular, the working paper will address issues pertaining to the Lisbon Treaty’s organising principles of EU external action, both under EU

Can the Copernican principle be tested using the cosmic neutrino background?

International Nuclear Information System (INIS)

Jia, Junji; Zhang, Hongbao

2008-01-01

The Copernican principle, stating that we do not occupy any special place in our universe, is usually taken for granted in modern cosmology. However recent observational supernova data indicate that we may live in the under-dense center of our universe, which challenges the Copernican principle. It thus becomes urgent and important to test the Copernican principle via cosmological observations. Taking into account that unlike cosmic photons, cosmic neutrinos of different energies come from different places to us, along different worldlines, we here propose using the cosmic neutrino background as a test of the Copernican principle. It is shown that from the theoretical perspective, the cosmic neutrino background can allow one to determine whether the Copernican principle is valid or not, but to implement such an observation, larger neutrino detectors are called for

Testing the principle of equivalence by solar neutrinos

International Nuclear Information System (INIS)

Minakata, Hisakazu; Washington Univ., Seattle, WA; Nunokawa, Hiroshi; Washington Univ., Seattle, WA

1994-04-01

We discuss the possibility of testing the principle of equivalence with solar neutrinos. If there exists a violation of the equivalence principle quarks and leptons with different flavors may not universally couple with gravity. The method we discuss employs a quantum mechanical phenomenon of neutrino oscillation to probe into the non-university of the gravitational couplings of neutrinos. We develop an appropriate formalism to deal with neutrino propagation under the weak gravitational fields of the sun in the presence of the flavor mixing. We point out that solar neutrino observation by the next generation water Cherenkov detectors can improve the existing bound on violation of the equivalence principle by 3-4 orders of magnitude if the nonadiabatic Mikheyev-Smirnov-Wolfenstein mechanism is the solution to the solar neutrino problem

Testing the principle of equivalence by solar neutrinos

International Nuclear Information System (INIS)

Minakata, H.; Nunokawa, H.

1995-01-01

We discuss the possibility of testing the principle of equivalence with solar neutrinos. If there exists a violation of the equivalence principle, quarks and leptons with different flavors may not universally couple with gravity. The method we discuss employs the quantum mechanical phenomenon of neutrino oscillation to probe into the nonuniversality of the gravitational couplings of neutrinos. We develop an appropriate formalism to deal with neutrino propagation under the weak gravitational fields of the Sun in the presence of the flavor mixing. We point out that solar neutrino observation by the next generation water Cherenkov detectors can place stringent bounds on the violation of the equivalence principle to 1 part in 10 15 --10 16 if the nonadiabatic Mikheyev-Smirnov-Wolfenstein mechanism is the solution to the solar neutrino problem

Bateman's principle is reversed in a cooperatively breeding bird.

Science.gov (United States)

Apakupakul, Kathleen; Rubenstein, Dustin R

2015-04-01

Bateman's principle is not only used to explain sex differences in mating behaviour, but also to determine which sex has the greater opportunity for sexual selection. It predicts that the relationship between the number of mates and the number of offspring produced should be stronger for males than for females. Yet, it is unclear whether Bateman's principle holds in cooperatively breeding systems where the strength of selection on traits used in intrasexual competition is high in both sexes. We tested Bateman's principle in the cooperatively breeding superb starling (Lamprotornis superbus), finding that only females showed a significant, positive Bateman gradient. We also found that the opportunity for selection was on average higher in females, but that its strength and direction oscillated through time. These data are consistent with the hypothesis that sexual selection underlies the female trait elaboration observed in superb starlings and other cooperative breeders. Even though the Bateman gradient was steeper for females than for males, the year-to-year oscillation in the strength and direction of the opportunity for selection likely explains why cooperative breeders do not exhibit sexual role reversal. Thus, Bateman's principle may not hold in cooperative breeders where both sexes appear to be under mutually strong sexual selection. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

Expanding Uncertainty Principle to Certainty-Uncertainty Principles with Neutrosophy and Quad-stage Method

Directory of Open Access Journals (Sweden)

Fu Yuhua

2015-03-01

Full Text Available The most famous contribution of Heisenberg is uncertainty principle. But the original uncertainty principle is improper. Considering all the possible situations (including the case that people can create laws and applying Neutrosophy and Quad-stage Method, this paper presents "certainty-uncertainty principles" with general form and variable dimension fractal form. According to the classification of Neutrosophy, "certainty-uncertainty principles" can be divided into three principles in different conditions: "certainty principle", namely a particle’s position and momentum can be known simultaneously; "uncertainty principle", namely a particle’s position and momentum cannot be known simultaneously; and neutral (fuzzy "indeterminacy principle", namely whether or not a particle’s position and momentum can be known simultaneously is undetermined. The special cases of "certain ty-uncertainty principles" include the original uncertainty principle and Ozawa inequality. In addition, in accordance with the original uncertainty principle, discussing high-speed particle’s speed and track with Newton mechanics is unreasonable; but according to "certaintyuncertainty principles", Newton mechanics can be used to discuss the problem of gravitational defection of a photon orbit around the Sun (it gives the same result of deflection angle as given by general relativity. Finally, for the reason that in physics the principles, laws and the like that are regardless of the principle (law of conservation of energy may be invalid; therefore "certaintyuncertainty principles" should be restricted (or constrained by principle (law of conservation of energy, and thus it can satisfy the principle (law of conservation of energy.

[Application criteria of the precautionary principle].

Science.gov (United States)

Moccaldi, R

2011-01-01

The precautionary principle, according to the European Commission (February 2, 2000) must be applied when there is a possibility of a danger to humans, animals and/or environment health, i.e. when the potential harmful effects have been identified by a scientific and objective evaluation, but this evaluation does not allow the risk to be determined with sufficient certainty. However this principle has been invoked, without the identification, even partial, of harmful effects, to justify preventive and protective measures deemed necessary by policy maker mainly due to a high (but unjustified) risk perception by the population. We analyze the examples of the limits imposed by Italian legislation for the protection from EMF, and measures of "prudent avoidance" in the use of mobile phones.

Universal Instructional Design Principles for Moodle

Directory of Open Access Journals (Sweden)

Tanya Elias

2010-05-01

Full Text Available The paper identifies a set of universal instructional design (UID principles appropriate to distance education (DE and tailored to the needs of instructional designers and instructors teaching online. These principles are then used to assess the accessibility level of a sample online course and the availability of options in its LMS platform (Moodle to increase course accessibility. Numerous accessibility-sensitive plug-in modules are found to be available to Moodle users, though relatively few features were included in the sample course analysed. This may be because they have not been made available to instructors at the institutional level. The paper offers a series of recommendations to improve the accessibility of online DE to learners with diverse abilities, disabilities, and needs.

Management Principles for Nonproliferation Organizations

International Nuclear Information System (INIS)

Frazar, Sarah L.; Hund, Gretchen

2012-01-01

This paper identifies business models and six management principles that can be applied by a nonproliferation organization to maximize the value and effectiveness of its products. The organizations responsible for reducing the nuclear proliferation threat have experienced a substantial growth in responsibility and visibility since the September 11 attacks. Since then, the international community has witnessed revelations of clandestine nuclear facilities, nuclear black markets, periodic nuclear tests, and a resurgence of interest by countries worldwide in developing nuclear capabilities. The security environment will likely continue to evolve in unexpected ways since most of the proliferation threats with which the world will be forced to contend remain unforeseen. To better prepare for and respond to this evolving security environment, many nonproliferation organizations are interested in finding new or better ways to increase the effectiveness and efficiency of their operations. Of course, all organizations, whether they are market driven or non-profit, must operate effectively and efficiently if they are to succeed. Indeed, as this study demonstrates, many of the management principles that this study recommends can help all organizations succeed. However, this study pays particular attention to nonproliferation organizations because of the mission they are responsible for fulfilling. Nonproliferation organizations, including nonproliferation programs that operate within a larger national security organization, are responsible for reducing the threat of nuclear, chemical and biological weapons. These organizations have an enduring mandate from the public and the international community not to fail in the completion of their mission for failure could have detrimental impacts on international security, public health and the environment. Moreover, the public expects nonproliferation organizations and programs to fulfill their mission, even when resources are limited

Management Principles for Nonproliferation Organizations

Energy Technology Data Exchange (ETDEWEB)

Frazar, Sarah L.; Hund, Gretchen

2012-03-06

This paper identifies business models and six management principles that can be applied by a nonproliferation organization to maximize the value and effectiveness of its products. The organizations responsible for reducing the nuclear proliferation threat have experienced a substantial growth in responsibility and visibility since the September 11 attacks. Since then, the international community has witnessed revelations of clandestine nuclear facilities, nuclear black markets, periodic nuclear tests, and a resurgence of interest by countries worldwide in developing nuclear capabilities. The security environment will likely continue to evolve in unexpected ways since most of the proliferation threats with which the world will be forced to contend remain unforeseen. To better prepare for and respond to this evolving security environment, many nonproliferation organizations are interested in finding new or better ways to increase the effectiveness and efficiency of their operations. Of course, all organizations, whether they are market driven or non-profit, must operate effectively and efficiently if they are to succeed. Indeed, as this study demonstrates, many of the management principles that this study recommends can help all organizations succeed. However, this study pays particular attention to nonproliferation organizations because of the mission they are responsible for fulfilling. Nonproliferation organizations, including nonproliferation programs that operate within a larger national security organization, are responsible for reducing the threat of nuclear, chemical and biological weapons. These organizations have an enduring mandate from the public and the international community not to fail in the completion of their mission for failure could have detrimental impacts on international security, public health and the environment. Moreover, the public expects nonproliferation organizations and programs to fulfill their mission, even when resources are limited

Identifying organisational principles and management practices important to the quality of health care services for chronic conditions.

Science.gov (United States)

Frølich, Anne

2012-02-01

The quality of health care services offered to people suffering from chronic diseases often fails to meet standards in Denmark or internationally. The population consisting of people with chronic diseases is large and accounts for about 70% of total health care expenses. Given that resources are limited, it is necessary to identify efficient methods to improve the quality of care. Comparing health care systems is a well-known method for identifying new knowledge regarding, for instance, organisational methods and principles. Kaiser Permanente (KP), an integrated health care delivery system in the U.S., is recognized as providing high-quality chronic care; to some extent, this is due to KP's implementation of the chronic care model (CCM). This model recommends a range of evidence-based management practices that support the implementation of evidence-based medicine. However, it is not clear which management practices in the CCM are most efficient and in what combinations. In addition, financial incentives and public reporting of performance are often considered effective at improving the quality of health care services, but this has not yet been definitively proved. The aim of this dissertation is to describe the effect of determinants, such as organisational structures and management practices including two selected incentives, on the quality of care in chronic diseases. The dissertation is based on four studies with the following purposes: 1) macro- or healthcare system-level identification of organisational structures and principles that affect the quality of health care services, based on a comparison of KP and the Danish health care system; 2) meso- or organisation-level identification of management practices with positive effects on screening rates for hemoglobin A1c and lipid profile in diabetes; 3) evaluation of the effect of the CCM on quality of health care services and continuity of care in a Danish setting; 4) micro- or practice-level evaluation of the

Identifying Needs and Opportunities for Local Government ...

African Journals Online (AJOL)

4carolinebell@gmail.com

attainment of sustainable development goals and socio-ecological balance in ... However, policy and legislation fall short of identifying the range of a priori competences ..... the precautionary principle, risk identification, risk management and ...

Game Design Principles based on Human Error

Directory of Open Access Journals (Sweden)

Guilherme Zaffari

2016-03-01

Full Text Available This paper displays the result of the authors’ research regarding to the incorporation of Human Error, through design principles, to video game design. In a general way, designers must consider Human Error factors throughout video game interface development; however, when related to its core design, adaptations are in need, since challenge is an important factor for fun and under the perspective of Human Error, challenge can be considered as a flaw in the system. The research utilized Human Error classifications, data triangulation via predictive human error analysis, and the expanded flow theory to allow the design of a set of principles in order to match the design of playful challenges with the principles of Human Error. From the results, it was possible to conclude that the application of Human Error in game design has a positive effect on player experience, allowing it to interact only with errors associated with the intended aesthetics of the game.

A variational principle for the plasma centrifuge

International Nuclear Information System (INIS)

Ludwig, G.O.

1986-09-01

A variational principle is derived which describes the stationary state of the plasma column in a plasma centrifuge. Starting with the fluid equations in a rotating frame the theory is developed using the method of irreversible thermodynamics. This formulation easily leads to an expression for the density distribution of the l-species at sedimentation equilibrium, taking into account the effect of the electric and magnetic forces. Assuming stationary boundary conditions and rigid rotation nonequilibrium states the condition for thermodynamic stability integrated over the volume of the system reduces, under certain restrictions, to the principle of minimum entropy production in the stationary state. This principle yields a variational problem which is equivalent to the original problem posed by the stationary fluid equations. The variational method is useful in achieving approximate solutions that give the electric potential and current distributions in the rotating plasma column consistent with an assumed plasma density profile. (Author) [pt

Learning Characteristics of Small Business Managers: Principles for Training

Science.gov (United States)

Jeffrey, Lynn M.; Hide, Sophie; Legg, Stephen

2010-01-01

Purpose: This paper aims to report on the second half of a two-part study that identified relevant content for safety audit training in small businesses. The specific aim of the paper is to determine the preferred learning styles and approaches of managers in these businesses in order to identify some principles which could be used to tailor…

77 FR 11778 - Reform of Federal Policies Relating to Grants and Cooperative Agreements; Cost Principles and...

Science.gov (United States)

2012-02-28

... and II Reform of Federal Policies Relating to Grants and Cooperative Agreements; Cost Principles and... available on OMB's Web site at http://www.whitehouse.gov/omb/circulars_default/ . The Cost Principles for... E (Principles for Determining Costs Applicable to Research and Development Under Grants and...

Genome-wide association study identified CNP12587 region underlying height variation in Chinese females.

Directory of Open Access Journals (Sweden)

Yin-Ping Zhang

Full Text Available Human height is a highly heritable trait considered as an important factor for health. There has been limited success in identifying the genetic factors underlying height variation. We aim to identify sequence variants associated with adult height by a genome-wide association study of copy number variants (CNVs in Chinese.Genome-wide CNV association analyses were conducted in 1,625 unrelated Chinese adults and sex specific subgroup for height variation, respectively. Height was measured with a stadiometer. Affymetrix SNP6.0 genotyping platform was used to identify copy number polymorphisms (CNPs. We constructed a genomic map containing 1,009 CNPs in Chinese individuals and performed a genome-wide association study of CNPs with height.We detected 10 significant association signals for height (p<0.05 in the whole population, 9 and 11 association signals for Chinese female and male population, respectively. A copy number polymorphism (CNP12587, chr18:54081842-54086942, p = 2.41 × 10(-4 was found to be significantly associated with height variation in Chinese females even after strict Bonferroni correction (p = 0.048. Confirmatory real time PCR experiments lent further support for CNV validation. Compared to female subjects with two copies of the CNP, carriers of three copies had an average of 8.1% decrease in height. An important candidate gene, ubiquitin-protein ligase NEDD4-like (NEDD4L, was detected at this region, which plays important roles in bone metabolism by binding to bone formation regulators.Our findings suggest the important genetic variants underlying height variation in Chinese.

DETERMINATION OF QMS PRINCIPLE COEFFICIENTS OF SIGNIFICANCE IN ACHIEVING BUSINESS EXCELLENCE

Directory of Open Access Journals (Sweden)

Aleksandar Vujovic

2008-03-01

Full Text Available This paper has been developed as a tendency of researchers in the Center for quality-Faculty of mechanical engineering in Podgorica to establish a model for improvement of business processes performances based on quality management system through comparison with top organizational performances characterized by criteria i.e. particularities of the business excellence model. Correlation of principles of the quality management system with QMS principles has been established to that effect. Weight coefficients have been also determined for each principle individually. Thereby key principles were identified, namely priorities in terms of achieving business excellence i.e. areas (principles were given priorities, that is to say principles that play the biggest part in achieving business excellence. In that way, pre conditions were made to define preventive measures of a certain intensity depending on the weight coefficients, with a goal to improve performances of a certified and process-modulated quality management system in direction of achieving top organizational performances.

Nonlinear optics principles and applications

CERN Document Server

Li, Chunfei

2017-01-01

This book reflects the latest advances in nonlinear optics. Besides the simple, strict mathematical deduction, it also discusses the experimental verification and possible future applications, such as the all-optical switches. It consistently uses the practical unit system throughout. It employs simple physical images, such as "light waves" and "photons" to systematically explain the main principles of nonlinear optical effects. It uses the first-order nonlinear wave equation in frequency domain under the condition of “slowly varying amplitude approximation" and the classical model of the interaction between the light and electric dipole. At the same time, it also uses the rate equations based on the energy-level transition of particle systems excited by photons and the energy and momentum conservation principles to explain the nonlinear optical phenomenon. The book is intended for researchers, engineers and graduate students in the field of the optics, optoelectronics, fiber communication, information tech...

Dimensional cosmological principles

International Nuclear Information System (INIS)

Chi, L.K.

1985-01-01

The dimensional cosmological principles proposed by Wesson require that the density, pressure, and mass of cosmological models be functions of the dimensionless variables which are themselves combinations of the gravitational constant, the speed of light, and the spacetime coordinates. The space coordinate is not the comoving coordinate. In this paper, the dimensional cosmological principle and the dimensional perfect cosmological principle are reformulated by using the comoving coordinate. The dimensional perfect cosmological principle is further modified to allow the possibility that mass creation may occur. Self-similar spacetimes are found to be models obeying the new dimensional cosmological principle

Key principles to improve programmes and interventions in complementary feeding.

Science.gov (United States)

Lutter, Chessa K; Iannotti, Lora; Creed-Kanashiro, Hilary; Guyon, Agnes; Daelmans, Bernadette; Robert, Rebecca; Haider, Rukhsana

2013-09-01

Although there are some examples of successful complementary feeding programmes to promote healthy growth and prevent stunting at the community level, to date there are few, if any, examples of successful programmes at scale. A lack of systematic process and impact evaluations on pilot projects to generate lessons learned has precluded scaling up of effective programmes. Programmes to effect positive change in nutrition rarely follow systematic planning, implementation, and evaluation (PIE) processes to enhance effectiveness over the long term. As a result a set of programme-oriented key principles to promote healthy growth remains elusive. The purpose of this paper is to fill this gap by proposing a set of principles to improve programmes and interventions to promote healthy growth and development. Identifying such principles for programme success has three requirements: rethinking traditional paradigms used to promote improved infant and young child feeding; ensuring better linkages to delivery platforms; and, improving programming. Following the PIE model for programmes and learning from experiences from four relatively large-scale programmes described in this paper, 10 key principles are identified in the areas of programme planning, programme implementation, programme evaluation, and dissemination, replication, and scaling up. Nonetheless, numerous operational research questions remain, some of which are highlighted in this paper. © 2013 John Wiley & Sons Ltd.

The likelihood principle and its proof – a never-ending story…

DEFF Research Database (Denmark)

Jørgensen, Thomas Martini

2015-01-01

An ongoing controversy in philosophy of statistics is the so-called “likelihood principle” essentially stating that all evidence which is obtained from an experiment about an unknown quantity θ is contained in the likelihood function of θ. Common classical statistical methodology, such as the use...... of significance tests, and confidence intervals, depends on the experimental procedure and unrealized events and thus violates the likelihood principle. The likelihood principle was identified by that name and proved in a famous paper by Allan Birnbaum in 1962. However, ever since both the principle itself...... as well as the proof has been highly debated. This presentation will illustrate the debate of both the principle and its proof, from 1962 and up to today. An often-used experiment to illustrate the controversy between classical interpretation and evidential confirmation based on the likelihood principle...

Risk analysis under uncertainty, the precautionary principle, and the new EU chemicals strategy.

Science.gov (United States)

Rogers, Michael D

2003-06-01

Three categories of uncertainty in relation to risk assessment are defined; uncertainty in effect, uncertainty in cause, and uncertainty in the relationship between a hypothesised cause and effect. The Precautionary Principle (PP) relates to the third type of uncertainty. Three broad descriptions of the PP are set out, uncertainty justifies action, uncertainty requires action, and uncertainty requires a reversal of the burden of proof for risk assessments. The application of the PP is controversial but what matters in practise is the precautionary action (PA) that follows. The criteria by which the PAs should be judged are detailed. This framework for risk assessment and management under uncertainty is then applied to the envisaged European system for the regulation of chemicals. A new EU regulatory system has been proposed which shifts the burden of proof concerning risk assessments from the regulator to the producer, and embodies the PP in all three of its main regulatory stages. The proposals are critically discussed in relation to three chemicals, namely, atrazine (an endocrine disrupter), cadmium (toxic and possibly carcinogenic), and hydrogen fluoride (a toxic, high-production-volume chemical). Reversing the burden of proof will speed up the regulatory process but the examples demonstrate that applying the PP appropriately, and balancing the countervailing risks and the socio-economic benefits, will continue to be a difficult task for the regulator. The paper concludes with a discussion of the role of precaution in the management of change and of the importance of trust in the effective regulation of uncertain risks.

Identifying blood biomarkers and physiological processes that distinguish humans with superior performance under psychological stress.

Directory of Open Access Journals (Sweden)

Amanda M Cooksey

2009-12-01

Full Text Available Attrition of students from aviation training is a serious financial and operational concern for the U.S. Navy. Each late stage navy aviator training failure costs the taxpayer over $1,000,000 and ultimately results in decreased operational readiness of the fleet. Currently, potential aviators are selected based on the Aviation Selection Test Battery (ASTB, which is a series of multiple-choice tests that evaluate basic and aviation-related knowledge and ability. However, the ASTB does not evaluate a person's response to stress. This is important because operating sophisticated aircraft demands exceptional performance and causes high psychological stress. Some people are more resistant to this type of stress, and consequently better able to cope with the demands of naval aviation, than others.Although many psychological studies have examined psychological stress resistance none have taken advantage of the human genome sequence. Here we use high-throughput -omic biology methods and a novel statistical data normalization method to identify plasma proteins associated with human performance under psychological stress. We identified proteins involved in four basic physiological processes: innate immunity, cardiac function, coagulation and plasma lipid physiology.The proteins identified here further elucidate the physiological response to psychological stress and suggest a hypothesis that stress-susceptible pilots may be more prone to shock. This work also provides potential biomarkers for screening humans for capability of superior performance under stress.

Industrial instrumentation principles and design

CERN Document Server

Padmanabhan, Tattamangalam R

2000-01-01

Pneumatic, hydraulic and allied instrumentation schemes have given way to electronic schemes in recent years thanks to the rapid strides in electronics and allied areas. Principles, design and applications of such state-of-the-art instrumentation schemes form the subject matter of this book. Through representative examples, the basic building blocks of instrumentation schemes are identified and each of these building blocks discussed in terms of its design and interface characteristics. The common generic schemes synthesized with such building blocks are dealt with subsequently. This forms the scope of Part I. The focus in Part II is on application. Displacement and allied instrumentation, force and allied instrumentation and process instrumentation in terms of temperature, flow, pressure level and other common process variables are dealt with separately and exhaustively. Despite the diversity in the sensor principles and characteristics and the variety in the applications and their environments, it is possib...

The prevention and control of feather pecking in laying hens : identifying the underlying principles

NARCIS (Netherlands)

Rodenburg, T. B.; van Krimpen, M. M.; de Jong, I. C.; de Haas, E. N.; Kops, M. S.; Riedstra, B. J.; Nordquist, R. E.; Wagenaar, J. P.; Bestman, M.; Nicol, C. J.

Feather pecking (FP) in laying hens remains an important economic and welfare issue. This paper reviews the literature on causes of FP in laying hens. With the ban on conventional cages in the EU from 2012 and the expected future ban on beak trimming in many European countries, addressing this

Current status of the development of international exemption principles

International Nuclear Information System (INIS)

Kennedy, W.E. Jr.

1988-01-01

For the past several years, the International Atomic Energy Agency (IAEA) has been investigating the possibility of exempting certain radiation sources and practices from regulatory control. Initial efforts were conducted under the general heading of de minimis. Interest in this topic arises from international recognition that a significant fraction of the wastes from industry, research, medicine, and the nuclear fuel cycle are contaminated to such low levels that applying regulatory controls may be unwarranted. The IAEA evaluation has been conducted by Advisory Groups considering two interrelated topics: to establish principles for exemption, and to apply the principles to various areas of waste management. The IAEA Advisory Groups developed the criteria from modeled assessments of the potential radiation exposure pathways and scenarios for individuals and population groups following the unrestricted release of radioactive materials. Although the scenarios and models used by the IAEA are necessarily generic, consultants to the Advisory Groups attempted to identify the most important radiation exposure pathways based on available literature. This approach is intended to provide the basic framework for the numerical derivation of generic exempt quantities that would be conservative in most situations. This paper discusses the current status of the IAEA's efforts on the subject of exemption and presents the generic results expressed as overall exemption limits for municipal wastes and materials for recycle and reuse

Insights into the ammonia synthesis from first-principles

DEFF Research Database (Denmark)

Hellmann, A.; Honkala, Johanna Karoliina; Remediakis, Ioannis

2006-01-01

-properties, such as apparent activation energies and reaction orders, are calculated from the first-principles model. Our analysis shows that the reaction order of N-2 is unity under all considered conditions, whereas the reaction orders of H-2 and NH3 depend on reaction conditions. (c) 2006 Elsevier B.V. All rights reserved.......A new set of measurements is used to further test a recently published first-principles model for the ammonia (NH3) synthesis on an unpromoted Ru-based catalyst. A direct comparison shows an overall good agreement in NH3 productivity between the model and the experiment. In addition, macro...

Design principles of a conditional futile cycle exploited for regulation.

Science.gov (United States)

Tolla, Dean A; Kiley, Patricia J; Lomnitz, Jason G; Savageau, Michael A

2015-07-01

In this report, we characterize the design principles of futile cycling in providing rapid adaptation by regulatory proteins that act as environmental sensors. In contrast to the energetically wasteful futile cycles that are avoided in metabolic pathways, here we describe a conditional futile cycle exploited for a regulatory benefit. The FNR (fumarate and nitrate reduction) cycle in Escherichia coli operates under two regimes - a strictly futile cycle in the presence of O2 and as a pathway under anoxic conditions. The computational results presented here use FNR as a model system and provide evidence that cycling of this transcription factor and its labile sensory cofactor between active and inactive states affords rapid signaling and adaptation. We modify a previously developed mechanistic model to examine a family of FNR models each with different cycling speeds but mathematically constrained to be otherwise equivalent, and we identify a trade-off between energy expenditure and response time that can be tuned by evolution to optimize cycling rate of the FNR system for a particular ecological context. Simulations mimicking experiments with proposed double mutant strains offer suggestions for experimentally testing our predictions and identifying potential fitness effects. Our approach provides a computational framework for analyzing other conditional futile cycles, which when placed in their larger biological context may be found to confer advantages to the organism.

Do positrons and antiprotons respect the weak equivalence principle?

International Nuclear Information System (INIS)

Hughes, R.J.

1990-01-01

We resolve the difficulties which Morrison identified with energy conservation and the gravitational red-shift when particles of antimatter, such as the positron and antiproton, do not respect the weak equivalence principle. 13 refs

First-principles study on the phase transition, elastic properties and electronic structure of Pt{sub 3}Al alloys under high pressure

Energy Technology Data Exchange (ETDEWEB)

Liu, Yanjun [Key Laboratory of Oil and Gas Equipment of Ministry of Education, Southwest Petroleum University, Chengdu, Sichuan 610500 (China); Huang, Huawei [National Key Laboratory for Nuclear Fuel and Materials, Nuclear Power of China, Chengdu, Sichuan 610041 (China); Pan, Yong, E-mail: yongpanyn@163.com [State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming 650106 (China); Zhao, Guanghui; Liang, Zheng [Key Laboratory of Oil and Gas Equipment of Ministry of Education, Southwest Petroleum University, Chengdu, Sichuan 610500 (China)

2014-06-01

Highlights: • The phase transition of Pt{sub 3}Al alloys occurs at 60 GPa. • The elastic modulus of Pt{sub 3}Al alloys increase with increasing pressure. • The cubic structure has good resistance to volume deformation under high pressure. • The pressure enhances the hybridization between Pt atom and Al atom. - Abstract: The phase transition, formation enthalpies, elastic properties and electronic structure of Pt{sub 3}Al alloys are studied using first-principle approach. The calculated results show that the pressure leads to phase transition from tetragonal structure to cubic structure at 60 GPa. With increasing pressure, the elastic constants, bulk modulus and shear modulus of these Pt{sub 3}Al alloys increase linearly and the bond lengths of Pt–Al metallic bonds and the peak at E{sub F} decrease. The cubic Pt{sub 3}Al alloy has excellent resistance to volume deformation under high pressure. We suggest that the phase transition is derived from the hybridization between Pt and Al atoms for cubic structure is stronger than that of tetragonal structure and forms the strong Pt–Al metallic bonds under high pressure.

The extent of knowledge of Quick Response Manufacturing principles : an exploratory transnational study

NARCIS (Netherlands)

Godinho Filho, Moacir; Marchesini, Antonio Gilberto; Riezebos, Jan; Vandaele, Nico; Devos Ganga, Gilberto Miller

2017-01-01

The main goal of this research is to identify whether companies that have implemented the Quick Response Manufacturing (QRM) approach have full knowledge of the QRM principles or have merely applied the elements ( principles and tools) that have a close relationship with Lean Manufacturing. Based on

Unified reduction principle for the evolution of mutation, migration, and recombination

Science.gov (United States)

Altenberg, Lee; Liberman, Uri; Feldman, Marcus W.

2017-01-01

Modifier-gene models for the evolution of genetic information transmission between generations of organisms exhibit the reduction principle: Selection favors reduction in the rate of variation production in populations near equilibrium under a balance of constant viability selection and variation production. Whereas this outcome has been proven for a variety of genetic models, it has not been proven in general for multiallelic genetic models of mutation, migration, and recombination modification with arbitrary linkage between the modifier and major genes under viability selection. We show that the reduction principle holds for all of these cases by developing a unifying mathematical framework that characterizes all of these evolutionary models. PMID:28265103

Learning Bounds of ERM Principle for Sequences of Time-Dependent Samples

Directory of Open Access Journals (Sweden)

Mingchen Yao

2015-01-01

Full Text Available Many generalization results in learning theory are established under the assumption that samples are independent and identically distributed (i.i.d.. However, numerous learning tasks in practical applications involve the time-dependent data. In this paper, we propose a theoretical framework to analyze the generalization performance of the empirical risk minimization (ERM principle for sequences of time-dependent samples (TDS. In particular, we first present the generalization bound of ERM principle for TDS. By introducing some auxiliary quantities, we also give a further analysis of the generalization properties and the asymptotical behaviors of ERM principle for TDS.

Principle-based concept analysis: Caring in nursing education.

Science.gov (United States)

Salehian, Maryam; Heydari, Abbas; Aghebati, Nahid; Karimi Moonaghi, Hossein; Mazloom, Seyed Reza

2016-03-01

The aim of this principle-based concept analysis was to analyze caring in nursing education and to explain the current state of the science based on epistemologic, pragmatic, linguistic, and logical philosophical principles. A principle-based concept analysis method was used to analyze the nursing literature. The dataset included 46 English language studies, published from 2005 to 2014, and they were retrieved through PROQUEST, MEDLINE, CINAHL, ERIC, SCOPUS, and SID scientific databases. The key dimensions of the data were collected using a validated data-extraction sheet. The four principles of assessing pragmatic utility were used to analyze the data. The data were managed by using MAXQDA 10 software. The scientific literature that deals with caring in nursing education relies on implied meaning. Caring in nursing education refers to student-teacher interactions that are formed on the basis of human values and focused on the unique needs of the students (epistemological principle). The result of student-teacher interactions is the development of both the students and the teachers. Numerous applications of the concept of caring in nursing education are available in the literature (pragmatic principle). There is consistency in the meaning of the concept, as a central value of the faculty-student interaction (linguistic principle). Compared with other related concepts, such as "caring pedagogy," "value-based education," and "teaching excellence," caring in nursing education does not have exact and clear conceptual boundaries (logic principle). Caring in nursing education was identified as an approach to teaching and learning, and it is formed based on teacher-student interactions and sustainable human values. A greater understanding of the conceptual basis of caring in nursing education will improve the caring behaviors of teachers, create teaching-learning environments, and help experts in curriculum development.

Application of the principle of Open Initiatives in developing Trakai tourism infrastructure

Directory of Open Access Journals (Sweden)

Eugenijus Nazelskis

2013-01-01

Full Text Available This article aims to identify the principle of open initiatives, launched by Trakai resort municipality, which is focused on infrastructure development in order to open the way for widespread participation of natural and legal persons in infrastructure projects and to define the strategic directions in tourism development and infrastructure projects that apply this principle. In addition, it aims to assess the effectiveness of this principle as well as its practical benefits to the expansion of tourism infrastructure and the development of new tourism products.

Designing MOOC: a shared view on didactical principles

NARCIS (Netherlands)

Stoyanov, Slavi; De Vries, Fred

2018-01-01

The innovative impact of the paper can be highlighted by the following statements: 1. Applying the Group Concept Mapping, a non-traditional and power research methodology for objectively identifying the shared vision of a group of experts on MOOC didactical principles. 2. Defining MOOC didactical

A New Principle in Physics: the Principle 'Finiteness', and Some Consequences

International Nuclear Information System (INIS)

Sternlieb, Abraham

2010-01-01

In this paper I propose a new principle in physics: the principle of 'finiteness'. It stems from the definition of physics as a science that deals (among other things) with measurable dimensional physical quantities. Since measurement results, including their errors, are always finite, the principle of finiteness postulates that the mathematical formulation of 'legitimate' laws of physics should prevent exactly zero or infinite solutions. Some consequences of the principle of finiteness are discussed, in general, and then more specifically in the fields of special relativity, quantum mechanics, and quantum gravity. The consequences are derived independently of any other theory or principle in physics. I propose 'finiteness' as a postulate (like the constancy of the speed of light in vacuum, 'c'), as opposed to a notion whose validity has to be corroborated by, or derived theoretically or experimentally from other facts, theories, or principles.

THE DEVELOPMENT OF AN INSTRUMENT FOR MEASURING THE UNDERSTANDING OF PROFIT-MAXIMIZING PRINCIPLES.

Science.gov (United States)

MCCORMICK, FLOYD G.

THE PURPOSE OF THE STUDY WAS TO DEVELOP AN INSTRUMENT FOR MEASURING PROFIT-MAXIMIZING PRINCIPLES IN FARM MANAGEMENT WITH IMPLICATIONS FOR VOCATIONAL AGRICULTURE. PRINCIPLES WERE IDENTIFIED FROM LITERATURE SELECTED BY AGRICULTURAL ECONOMISTS. FORTY-FIVE MULTIPLE-CHOICE QUESTIONS WERE REFINED ON THE BASIS OF RESULTS OF THREE PRETESTS AND…

HSE's safety assessment principles for criticality safety

International Nuclear Information System (INIS)

Simister, D N; Finnerty, M D; Warburton, S J; Thomas, E A; Macphail, M R

2008-01-01

The Health and Safety Executive (HSE) published its revised Safety Assessment Principles for Nuclear Facilities (SAPs) in December 2006. The SAPs are primarily intended for use by HSE's inspectors when judging the adequacy of safety cases for nuclear facilities. The revised SAPs relate to all aspects of safety in nuclear facilities including the technical discipline of criticality safety. The purpose of this paper is to set out for the benefit of a wider audience some of the thinking behind the final published words and to provide an insight into the development of UK regulatory guidance. The paper notes that it is HSE's intention that the Safety Assessment Principles should be viewed as a reflection of good practice in the context of interpreting primary legislation such as the requirements under site licence conditions for arrangements for producing an adequate safety case and for producing a suitable and sufficient risk assessment under the Ionising Radiations Regulations 1999 (SI1999/3232 www.opsi.gov.uk/si/si1999/uksi_19993232_en.pdf). (memorandum)

Temporal Evolution of Design Principles in Engineering Systems: Analogies with Human Evolution

DEFF Research Database (Denmark)

Deb, Kalyanmoy; Bandaru, Sunith; Tutum, Cem Celal

2012-01-01

constructed later during optimization. Interestingly, there exists a simile between evolution of design principles with that of human evolution. Such information about the hierarchy of key design principles should enable designers to have a deeper understanding of their problems.......Optimization of an engineering system or component makes a series of changes in the initial random solution(s) iteratively to form the final optimal shape. When multiple conflicting objectives are considered, recent studies on innovization revealed the fact that the set of Pareto-optimal solutions...... portray certain common design principles. In this paper, we consider a 14-variable bi-objective design optimization of a MEMS device and identify a number of such common design principles through a recently proposed automated innovization procedure. Although these design principles are found to exist...

Identifying the genes underlying quantitative traits: a rationale for the QTN programme.

Science.gov (United States)

Lee, Young Wha; Gould, Billie A; Stinchcombe, John R

2014-01-01

The goal of identifying the genes or even nucleotides underlying quantitative and adaptive traits has been characterized as the 'QTN programme' and has recently come under severe criticism. Part of the reason for this criticism is that much of the QTN programme has asserted that finding the genes and nucleotides for adaptive and quantitative traits is a fundamental goal, without explaining why it is such a hallowed goal. Here we outline motivations for the QTN programme that offer general insight, regardless of whether QTNs are of large or small effect, and that aid our understanding of the mechanistic dynamics of adaptive evolution. We focus on five areas: (i) vertical integration of insight across different levels of biological organization, (ii) genetic parallelism and the role of pleiotropy in shaping evolutionary dynamics, (iii) understanding the forces maintaining genetic variation in populations, (iv) distinguishing between adaptation from standing variation and new mutation, and (v) the role of genomic architecture in facilitating adaptation. We argue that rather than abandoning the QTN programme, we should refocus our efforts on topics where molecular data will be the most effective for testing hypotheses about phenotypic evolution.

Identifying the genes underlying quantitative traits: a rationale for the QTN programme

Science.gov (United States)

Lee, Young Wha; Gould, Billie A.; Stinchcombe, John R.

2014-01-01

The goal of identifying the genes or even nucleotides underlying quantitative and adaptive traits has been characterized as the ‘QTN programme’ and has recently come under severe criticism. Part of the reason for this criticism is that much of the QTN programme has asserted that finding the genes and nucleotides for adaptive and quantitative traits is a fundamental goal, without explaining why it is such a hallowed goal. Here we outline motivations for the QTN programme that offer general insight, regardless of whether QTNs are of large or small effect, and that aid our understanding of the mechanistic dynamics of adaptive evolution. We focus on five areas: (i) vertical integration of insight across different levels of biological organization, (ii) genetic parallelism and the role of pleiotropy in shaping evolutionary dynamics, (iii) understanding the forces maintaining genetic variation in populations, (iv) distinguishing between adaptation from standing variation and new mutation, and (v) the role of genomic architecture in facilitating adaptation. We argue that rather than abandoning the QTN programme, we should refocus our efforts on topics where molecular data will be the most effective for testing hypotheses about phenotypic evolution. PMID:24790125

Devising Principles of Design for Numeracy Tasks

Science.gov (United States)

Geiger, Vince; Forgasz, Helen; Goos, Merrilyn; Bennison, Anne

2014-01-01

Numeracy is a fundamental component of the Australian National Curriculum as a General Capability identified in each F-10 subject. In this paper, we consider the principles of design necessary for the development of numeracy tasks specific to subjects other than mathematics--in this case, the subject of English. We explore the nature of potential…

Improving accuracy of electrochemical capacitance and solvation energetics in first-principles calculations

Science.gov (United States)

Sundararaman, Ravishankar; Letchworth-Weaver, Kendra; Schwarz, Kathleen A.

2018-04-01

Reliable first-principles calculations of electrochemical processes require accurate prediction of the interfacial capacitance, a challenge for current computationally efficient continuum solvation methodologies. We develop a model for the double layer of a metallic electrode that reproduces the features of the experimental capacitance of Ag(100) in a non-adsorbing, aqueous electrolyte, including a broad hump in the capacitance near the potential of zero charge and a dip in the capacitance under conditions of low ionic strength. Using this model, we identify the necessary characteristics of a solvation model suitable for first-principles electrochemistry of metal surfaces in non-adsorbing, aqueous electrolytes: dielectric and ionic nonlinearity, and a dielectric-only region at the interface. The dielectric nonlinearity, caused by the saturation of dipole rotational response in water, creates the capacitance hump, while ionic nonlinearity, caused by the compactness of the diffuse layer, generates the capacitance dip seen at low ionic strength. We show that none of the previously developed solvation models simultaneously meet all these criteria. We design the nonlinear electrochemical soft-sphere solvation model which both captures the capacitance features observed experimentally and serves as a general-purpose continuum solvation model.

Gene regulatory networks in lactation: identification of global principles using bioinformatics

Directory of Open Access Journals (Sweden)

Pollard Katherine S

2007-11-01

Full Text Available Abstract Background The molecular events underlying mammary development during pregnancy, lactation, and involution are incompletely understood. Results Mammary gland microarray data, cellular localization data, protein-protein interactions, and literature-mined genes were integrated and analyzed using statistics, principal component analysis, gene ontology analysis, pathway analysis, and network analysis to identify global biological principles that govern molecular events during pregnancy, lactation, and involution. Conclusion Several key principles were derived: (1 nearly a third of the transcriptome fluctuates to build, run, and disassemble the lactation apparatus; (2 genes encoding the secretory machinery are transcribed prior to lactation; (3 the diversity of the endogenous portion of the milk proteome is derived from fewer than 100 transcripts; (4 while some genes are differentially transcribed near the onset of lactation, the lactation switch is primarily post-transcriptionally mediated; (5 the secretion of materials during lactation occurs not by up-regulation of novel genomic functions, but by widespread transcriptional suppression of functions such as protein degradation and cell-environment communication; (6 the involution switch is primarily transcriptionally mediated; and (7 during early involution, the transcriptional state is partially reverted to the pre-lactation state. A new hypothesis for secretory diminution is suggested – milk production gradually declines because the secretory machinery is not transcriptionally replenished. A comprehensive network of protein interactions during lactation is assembled and new regulatory gene targets are identified. Less than one fifth of the transcriptionally regulated nodes in this lactation network have been previously explored in the context of lactation. Implications for future research in mammary and cancer biology are discussed.

Equivalence principles and electromagnetism

Science.gov (United States)

Ni, W.-T.

1977-01-01

The implications of the weak equivalence principles are investigated in detail for electromagnetic systems in a general framework. In particular, it is shown that the universality of free-fall trajectories (Galileo weak equivalence principle) does not imply the validity of the Einstein equivalence principle. However, the Galileo principle plus the universality of free-fall rotation states does imply the Einstein principle.

Quantum Action Principle with Generalized Uncertainty Principle

OpenAIRE

Gu, Jie

2013-01-01

One of the common features in all promising candidates of quantum gravity is the existence of a minimal length scale, which naturally emerges with a generalized uncertainty principle, or equivalently a modified commutation relation. Schwinger's quantum action principle was modified to incorporate this modification, and was applied to the calculation of the kernel of a free particle, partly recovering the result previously studied using path integral.

A mini-max principle for drift waves and mesoscale fluctuations

International Nuclear Information System (INIS)

Itoh, S-I; Itoh, K

2011-01-01

A mini-max principle for the system of the drift waves and mesoscale fluctuations (e.g. zonal flows, etc) is studied. For the system of model equations a Lyapunov function is constructed, which takes the minimum when the stationary state is realized. The dynamical evolution describes the access to the state that is realized. The competition between different mesoscale fluctuations is explained. The origins of irreversibility that cause an approach to the stationary state are discussed. A selection rule among fluctuations is derived, and conditions, under which different kinds of mesocale fluctuations coexist, are investigated. An analogy of this minimum principle to the principle of 'minimum Helmholtz free energy' in thermal equilibrium is shown.

Can quantum probes satisfy the weak equivalence principle?

International Nuclear Information System (INIS)

Seveso, Luigi; Paris, Matteo G.A.

2017-01-01

We address the question whether quantum probes in a gravitational field can be considered as test particles obeying the weak equivalence principle (WEP). A formulation of the WEP is proposed which applies also in the quantum regime, while maintaining the physical content of its classical counterpart. Such formulation requires the introduction of a gravitational field not to modify the Fisher information about the mass of a freely-falling probe, extractable through measurements of its position. We discover that, while in a uniform field quantum probes satisfy our formulation of the WEP exactly, gravity gradients can encode nontrivial information about the particle’s mass in its wavefunction, leading to violations of the WEP. - Highlights: • Can quantum probes under gravity be approximated as test-bodies? • A formulation of the weak equivalence principle for quantum probes is proposed. • Quantum probes are found to violate it as a matter of principle.

Can quantum probes satisfy the weak equivalence principle?

Energy Technology Data Exchange (ETDEWEB)

Seveso, Luigi, E-mail: luigi.seveso@unimi.it [Quantum Technology Lab, Dipartimento di Fisica, Università degli Studi di Milano, I-20133 Milano (Italy); Paris, Matteo G.A. [Quantum Technology Lab, Dipartimento di Fisica, Università degli Studi di Milano, I-20133 Milano (Italy); INFN, Sezione di Milano, I-20133 Milano (Italy)

2017-05-15

We address the question whether quantum probes in a gravitational field can be considered as test particles obeying the weak equivalence principle (WEP). A formulation of the WEP is proposed which applies also in the quantum regime, while maintaining the physical content of its classical counterpart. Such formulation requires the introduction of a gravitational field not to modify the Fisher information about the mass of a freely-falling probe, extractable through measurements of its position. We discover that, while in a uniform field quantum probes satisfy our formulation of the WEP exactly, gravity gradients can encode nontrivial information about the particle’s mass in its wavefunction, leading to violations of the WEP. - Highlights: • Can quantum probes under gravity be approximated as test-bodies? • A formulation of the weak equivalence principle for quantum probes is proposed. • Quantum probes are found to violate it as a matter of principle.

Designing User-Computer Dialogues: Basic Principles and Guidelines.

Science.gov (United States)

Harrell, Thomas H.

This discussion of the design of computerized psychological assessment or testing instruments stresses the importance of the well-designed computer-user interface. The principles underlying the three main functional elements of computer-user dialogue--data entry, data display, and sequential control--are discussed, and basic guidelines derived…

Compliance with best practice governance principles of South ...

African Journals Online (AJOL)

The heightened interest in sport shown by politicians, legislators, sponsors and government carries with it an inherent demand to justify long-term sustainability as well as compliance with best-practice corporate governance principles. A questionnaire based on the seven pillars of good corporate governance identified in ...

Expert systems - basic principles and possible applications in nuclear energy

International Nuclear Information System (INIS)

Cain, D.G.; Schmidt, F.

1987-01-01

One of the primary goals of the application of mathematical methods and computational techniques in reactor physics is the effective and accurate solution of the neutron diffusion equation under various conditions. To reach this goal still requires much skill, experience, knowledge and imagination as can be seen from various contributions at this and other conferences. Experts are necessary. Will expert systems replace them. We shall discuss this question by describing the basic principles of problem solving by expert systems as compared to problem solving by mathematical and computational methods. From this we shall identify areas of possible applications of the new techniques in nuclear energy and develop some thoughts on present limitations. As a result we conclude that expert systems will not be able to replace experts as long as the experts use the systems to improve their own expertise

Applying bioethical principles to human biomonitoring

Directory of Open Access Journals (Sweden)

Harrison Myron

2008-01-01

Full Text Available Abstract Bioethical principles are widely used as a normative framework in areas of human research and medical care. In recent years there has been increasing formalization of their use in public health decisions. The "traditional bioethical principles" are applied in this discussion to the important issue human biomonitoring for environmental exposures. They are: (1 Autonomy – Also known as the "respect for humans" principle, people understand their own best interests; (2 Beneficence – "do good" for people; (3 Nonmaleficence – "do no harm"; (4 Justice – fair distribution of benefits and costs (including risks to health across stakeholders. Some of the points made are: (1 There is not a single generic bioethical analysis applicable to the use of human biomonitoring data, each specific use requires a separate deliberation; (2 Using unidentified, population-based biomonitoring information for risk assessment or population surveillance raises fewer bioethical concerns than personally identified biomonitoring information such as employed in health screening; (3 Companies should proactively apply normative bioethical principles when considering the disposition of products and by-products in the environment and humans; (4 There is a need for more engagement by scholars on the bioethical issues raised by the use of biomarkers of exposure; (5 Though our scientific knowledge of biology will continue to increase, there will always be a role for methods or frameworks to resolve substantive disagreements in the meaning of this data that are matters of belief rather than knowledge.

Applying bioethical principles to human biomonitoring

Directory of Open Access Journals (Sweden)

Harrison Myron

2008-06-01

Full Text Available Abstract Bioethical principles are widely used as a normative framework in areas of human research and medical care. In recent years there has been increasing formalization of their use in public health decisions. The "traditional bioethical principles" are applied in this discussion to the important issue human biomonitoring for environmental exposures. They are: (1 Autonomy – Also known as the "respect for humans" principle, people understand their own best interests; (2 Beneficence – "do good" for people; (3 Nonmaleficence – "do no harm"; (4 Justice – fair distribution of benefits and costs (including risks to health across stakeholders. Some of the points made are: (1 There is not a single generic bioethical analysis applicable to the use of human biomonitoring data, each specific use requires a separate deliberation; (2 Using unidentified, population-based biomonitoring information for risk assessment or population surveillance raises fewer bioethical concerns than personally identified biomonitoring information such as employed in health screening; (3 Companies should proactively apply normative bioethical principles when considering the disposition of products and by-products in the environment and humans; (4 There is a need for more engagement by scholars on the bioethical issues raised by the use of biomarkers of exposure; (5 Though our scientific knowledge of biology will continue to increase, there will always be a role for methods or frameworks to resolve substantive disagreements in the meaning of this data that are matters of belief rather than knowledge.

The Use of Informational Formats to Implement APA Ethical Principles in Collecting Classroom Data.

Science.gov (United States)

Dolly, John P.; And Others

1978-01-01

Providing more information about experimental studies than required under the ethical principles formulated by the American Psychological Association can result in data bias on a specific task; overall, however, the implementation of ethical principles has little effect on data collected in classroom settings. (RL)

Friction reduction using discrete surface textures: principle and design

International Nuclear Information System (INIS)

Hsu, Stephen M; Jing, Yang; Hua, Diann; Zhang, Huan

2014-01-01

There have been many reports on the use of dimples, grooves, and other surface textures to control friction in sliding interfaces. The effectiveness of surface textures in friction reduction has been demonstrated in conformal contacts under high speed low load applications such as mechanical seals and automotive water pump seals, etc., resulting in reduced friction and longer durability. For sliding components with higher contact pressures or lower speeds, conflicting results were reported. Reasons for the inconsistency may be due to the differences in texture fabrication techniques, lack of dimple size and shape uniformity, and different tester used. This paper examines the basic principles on which surface textural patterns influence friction under the three principle lubrication regimes: hydrodynamic, elastohydrodynamic, and boundary lubrication regimes. Our findings suggest that each regime requires specific dimple size, shape, depth, and areal density to achieve friction reduction. Control experiments were also conducted to explore mechanisms of friction reduction. The dimple geometric shape and the dimple's orientation with respect to the sliding direction influence friction significantly. The underlying mechanisms for friction control via textures are discussed. (paper)

Modeling Success: Using Preenrollment Data to Identify Academically At-Risk Students

Science.gov (United States)

Gansemer-Topf, Ann M.; Compton, Jonathan; Wohlgemuth, Darin; Forbes, Greg; Ralston, Ekaterina

2015-01-01

Improving student success and degree completion is one of the core principles of strategic enrollment management. To address this principle, institutional data were used to develop a statistical model to identify academically at-risk students. The model employs multiple linear regression techniques to predict students at risk of earning below a…

Maximum Principle for General Controlled Systems Driven by Fractional Brownian Motions

International Nuclear Information System (INIS)

Han Yuecai; Hu Yaozhong; Song Jian

2013-01-01

We obtain a maximum principle for stochastic control problem of general controlled stochastic differential systems driven by fractional Brownian motions (of Hurst parameter H>1/2). This maximum principle specifies a system of equations that the optimal control must satisfy (necessary condition for the optimal control). This system of equations consists of a backward stochastic differential equation driven by both fractional Brownian motions and the corresponding underlying standard Brownian motions. In addition to this backward equation, the maximum principle also involves the Malliavin derivatives. Our approach is to use conditioning and Malliavin calculus. To arrive at our maximum principle we need to develop some new results of stochastic analysis of the controlled systems driven by fractional Brownian motions via fractional calculus. Our approach of conditioning and Malliavin calculus is also applied to classical system driven by standard Brownian motions while the controller has only partial information. As a straightforward consequence, the classical maximum principle is also deduced in this more natural and simpler way.

LEGAL PRINCIPLES IN FUNCTION AND PERFORMANCE OF BOT CONTRACT

Directory of Open Access Journals (Sweden)

Reifon Cristabella Eventia

2017-09-01

Full Text Available Build, Operate and Transfer (BOT represents a long term partnership of the government and private sector. In BOT project, either the government or a private sector identifies a need for a development project. The philosophy in BOT contract begins from the increasing infrastructural needs in all areas and with a limited budget, government are required to commit the duties and functions state governance so that the concept of BOT give a solution through a partnership with the private sector. The government then gives a concession to the private sector to build the project and operate it for a fixed period years, after the period ended, the building shall be transferred to the government. Through BOT, the country is able to gain asset without government spending while maintaining a measure of regulatory control over the project. BOT permits the government to use private sector fund to finance public infrastructure development. The main issues elaborated in this article are the legal principle in the formation of BOT contract and the legal principle in the performance of BOT contract. There are two results; firstly, in the formation of a BOT contract, the principles of partnership and the principle of transparency should be emphasized. Secondly, in performance of the BOT contract, the principle of risk management and the principle of proportionality should be clearly stated in the rules and legal norms.

Distractor Inhibition: Principles of Operation during Selective Attention

Science.gov (United States)

Wyatt, Natalie; Machado, Liana

2013-01-01

Research suggests that although target amplification acts as the main determinant of the efficacy of selective attention, distractor inhibition contributes under some circumstances. Here we aimed to gain insight into the operating principles that regulate the use of distractor inhibition during selective attention. The results suggest that, in…

The principles, procedures and pitfalls in identifying archaeological and historical wood samples.

Science.gov (United States)

Cartwright, Caroline R

2015-07-01

The science of wood anatomy has evolved in recent decades to add archaeological and historical wood to its repertoire of documenting and characterizing modern and fossil woods. The increasing use of online wood anatomy databases and atlases has fostered the adoption of an international consensus regarding terminology, largely through the work of the International Association of Wood Anatomists (IAWA). This review presents an overview for the general reader of the current state of principles and procedures involved in the study of the wood anatomy of archaeological and historical specimens, some of which may be preserved through charring, waterlogging, desiccation or mineral replacement. By means of selected case studies, the review evaluates to what extent varying preservation of wood anatomical characteristics limits the level of identification to taxon. It assesses the role played by increasingly accessible scanning electron microscopes and complex optical microscopes, and whether these, on the one hand, provide exceptional opportunities for high-quality imaging and analysis of difficult samples, but, on the other hand, might be misleading the novice into thinking that advanced technology can be a substitute for specialized botanical training in wood anatomy. © The Author 2015. Published by Oxford University Press on behalf of the Annals of Botany Company. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Principles and guidelines for radioactive waste disposal facilities

International Nuclear Information System (INIS)

1988-06-01

Four basic principles relevant to radioactive waste disposal identified. These principles cover the justification of the activity giving rise to the waste, the consideration of risk to present and future generations, the minimization of the need for intervention in the future, and the financial obligations of the licensee. The use of risk limits as opposed to dose limits associated with disposal is discussed, as are the concepts of critical group, de minimis, and ALARA, in the context of a waste disposal facility. Guidance is given on the selection of the preferred waste disposal concept from among several alternatives, and for judging proposed design improvements to the chosen concept

The Primacy of Principles: Exploring Journalism Educators' Democratic Imperative to Do Good Work

Science.gov (United States)

Winters, Caryn L.

2013-01-01

By engaging in an interdisciplinary examination of the democracy-education relationship, this humanistic inquiry will identify and explore the principles that define journalism educators' special obligation to do good work. My thesis is prefaced on the notion that determining the principles that guide what it means for educators to do good work in…

Fair Information Principles of Brazilian Companies online privacy policies

Directory of Open Access Journals (Sweden)

Patricia Zeni Marchiori

2016-05-01

Full Text Available This research aims to present the Fair Information Principles in the privacy policies of the websites of major Brazilian companies (according to the 2014 Forbes Magazine list. The check and analysis were supported by a checklist compiled from documents issued by the Federal Trade Commission and the Organization for Economic Co-operation and development. The study selected fourteen companies from a universe of twenty-five, considering the immediacy criterion of access to the privacy policy on their websites. The security (safeguards principle is the most widespread foundation at the privacy policies of the companies selected (existing in eight of the fourteen analyzed policies; and the principle of responsibility receives less adhesion due to the fact that it is not covered in any of the examined online privacy policies. The Sabesp Company presents the most complete privacy policy, considering the compliance with the Fair Information Principles when compared to the others perused, while WEG does not present any of the principles identified in the documental survey. As for e-commerce, the number of companies that assume some of the Principles is further reduced. For the selected universe the adherence to the Fair information Principles is still incipient, althought its use is not mandatory. An open discussion of the proposed Brazilian law about personal data protection should play an important role in creating further guidance on the subject. Additional studies in this subject should involve the perception of users, as well as a cutout of companies which target e-commerce, considering that an effective alignment with these principles and other guidelines are required in order to protect the user’s privacy and personal data in the web environment.

Cryogenic test of the equivalence principle

International Nuclear Information System (INIS)

Worden, P.W. Jr.

1976-01-01

The weak equivalence principle is the hypothesis that the ratio of internal and passive gravitational mass is the same for all bodies. A greatly improved test of this principle is possible in an orbiting satellite. The most promising experiments for an orbital test are adaptations of the Galilean free-fall experiment and the Eotvos balance. Sensitivity to gravity gradient noise, both from the earth and from the spacecraft, defines a limit to the sensitivity in each case. This limit is generally much worse for an Eotvos balance than for a properly designed free-fall experiment. The difference is related to the difficulty of making a balance sufficiently isoinertial. Cryogenic technology is desirable to take full advantage of the potential sensitivity, but tides in the liquid helium refrigerant may produce a gravity gradient that seriously degrades the ultimate sensitivity. The Eotvos balance appears to have a limiting sensitivity to relative difference of rate of fall of about 2 x 10 -14 in orbit. The free-fall experiment is limited by helium tide to about 10 -15 ; if the tide can be controlled or eliminated the limit may approach 10 -18 . Other limitations to equivalence principle experiments are discussed. An experimental test of some of the concepts involved in the orbital free-fall experiment is continuing. The experiment consists in comparing the motions of test masses levitated in a superconducting magnetic bearing, and is itself a sensitive test of the equivalence principle. At present the levitation magnets, position monitors and control coils have been tested and major noise sources identified. A measurement of the equivalence principle is postponed pending development of a system for digitizing data. The experiment and preliminary results are described

Toward Principles for Enhancing the Resilience of Ecosystem Services

NARCIS (Netherlands)

Biggs, R.; Schlüter, M.; Biggs, D.; Bohensky, E.L.; BurnSilver, S.; Cundill, G.; Dakos, V.; Daw, T.M.; Evans, L.S.; Kotschy, K.; Leitch, A.M.; Meek, C.; Quinlan, A.; Raudsepp-Hearne, C.; Robards, M.D.; Schoon, M.L.; Schultz, L.; West, P.C.

2012-01-01

Enhancing the resilience of ecosystem services (ES) that underpin human well-being is critical for meeting current and future societal needs, and requires specific governance and management policies. Using the literature, we identify seven generic policy-relevant principles for enhancing the

Identifying gene coexpression networks underlying the dynamic regulation of wood-forming tissues in Populus under diverse environmental conditions.

Science.gov (United States)

Zinkgraf, Matthew; Liu, Lijun; Groover, Andrew; Filkov, Vladimir

2017-06-01

Trees modify wood formation through integration of environmental and developmental signals in complex but poorly defined transcriptional networks, allowing trees to produce woody tissues appropriate to diverse environmental conditions. In order to identify relationships among genes expressed during wood formation, we integrated data from new and publically available datasets in Populus. These datasets were generated from woody tissue and include transcriptome profiling, transcription factor binding, DNA accessibility and genome-wide association mapping experiments. Coexpression modules were calculated, each of which contains genes showing similar expression patterns across experimental conditions, genotypes and treatments. Conserved gene coexpression modules (four modules totaling 8398 genes) were identified that were highly preserved across diverse environmental conditions and genetic backgrounds. Functional annotations as well as correlations with specific experimental treatments associated individual conserved modules with distinct biological processes underlying wood formation, such as cell-wall biosynthesis, meristem development and epigenetic pathways. Module genes were also enriched for DNase I hypersensitivity footprints and binding from four transcription factors associated with wood formation. The conserved modules are excellent candidates for modeling core developmental pathways common to wood formation in diverse environments and genotypes, and serve as testbeds for hypothesis generation and testing for future studies. No claim to original US government works. New Phytologist © 2017 New Phytologist Trust.

On Various R-duals and the Duality Principle

DEFF Research Database (Denmark)

Stoeva, Diana T.; Christensen, Ole

2016-01-01

to a characterization of frames in terms of associated Riesz sequences; however, it is still an open question whether this abstract theory is a generalization of the duality principle. In this paper we prove that a modified version of the R-duals leads to a generalization of the duality principle that keeps all......The duality principle states that a Gabor system is a frame if and only if the corresponding adjoint Gabor system is a Riesz sequence. In general Hilbert spaces and without the assumption of any particular structure, Casazza, Kutyniok and Lammers have introduced the so-called R-duals that also lead...... the attractive properties of the R-duals. In order to provide extra insight into the relations between a given sequence and its R-duals, we characterize all the types of R-duals that are available in the literature for the special case where the underlying sequence is a Riesz basis....

General principles of radiation protection in hospital media

International Nuclear Information System (INIS)

Chanteur, J.

1993-01-01

Principles of radiation protection given by ICRP in term of justification, optimization, limitation are applicable in hospital media. The medical act has to be justified and, in France, it is not possible to use ionizing radiations without a prescription from a doctor. The acceleration of technologies development make non radiological techniques more employed than radiologic ones, in an aim of efficiency more than an aim radiation protection. The second principle of optimization means to give medical care with the minimum of ionizing radiations for the patients as well the operators. For the principle of limitation which applied only for operators, we have the new recommends of ICRP, but it would be reasonable to give the most part of decision to the works doctor to decide if somebody has the aptitude to work at an exposed place. The last points concern the quality of equipment, the safety of installations, the organization of works which are under laws and regulations. 3 tabs

APPLYING THE PRINCIPLES OF ACCOUNTING IN

OpenAIRE

NAGY CRISTINA MIHAELA; SABĂU CRĂCIUN; ”Tibiscus” University of Timişoara, Faculty of Economic Science

2015-01-01

The application of accounting principles (accounting principle on accrual basis; principle of business continuity; method consistency principle; prudence principle; independence principle; the principle of separate valuation of assets and liabilities; intangibility principle; non-compensation principle; the principle of substance over form; the principle of threshold significance) to companies that are in bankruptcy procedure has a number of particularities. Thus, some principl...

Choking under Pressure: When an Additional Positive Stereotype Affects Performance for Domain Identified Male Mathematics Students

Science.gov (United States)

Rosenthal, Harriet E. S.; Crisp, Richard J.

2007-01-01

This research aimed to establish if the presentation of two positive stereotypes would result in choking under pressure for identified male mathematics students. Seventy-five 16 year old men, who had just commenced their AS-level study, were either made aware of their gender group membership (single positive stereotype), their school group…

Testing the violation of conservatism accounting principle. Case study on Romanian listed entities

Directory of Open Access Journals (Sweden)

Bunget Ovidiu Constantin

2015-12-01

Full Text Available From the beginning of the debates regarding the conservatism principle, the concept experienced a significant development. As it is one of the most controversial and violated accounting principle, we started to seek how can we help one of the auditor’s challenge in the audit mission: to identify and evaluate the risks from the financial statement level. The most affected accounting principle in Romania is the conservatism principle. After a long time of debates, it was stated that the conservatism principle, considered to be complementary to the “fair view” concept, which means that financial reports shall be required to submit information so impartial and in such a manner as to enable the reader to understand them clearly. Considered as a risk that should be identified, this study demonstrates a relationship between the violation of the conservatism principle and the analysis of the financial indicators, such as: Long-Term-Debt-to-Equity Ratio; Debt-to-Equity Ratio; Global Solvency Ratio; Operating Margin Ratio; Current Finance Ratio; Period of Activity Indicator and Auditor Indicator. Based on a quantitative method, this analyze was realized through three econometric model performed on annual financial statements of the companies from Bucharest Stock Exchange. After validating the sample and analyzing the factorial variables, we selected the best model: the probit model. In conclusion, as can be seen in the paper, the econometric function is efficient, reliable and can be applied to assess the risk likelihood for violating the conservatism principle by a Romanian company.

Self-Regulation Principles Underlying Risk Perception and Decision Making within the Context of Genomic Testing

Science.gov (United States)

Cameron, Linda D.; Biesecker, Barbara Bowles; Peters, Ellen; Taber, Jennifer M.; Klein, William M. P.

2017-01-01

Advances in theory and research on self-regulation and decision-making processes have yielded important insights into how cognitive, emotional, and social processes shape risk perceptions and risk-related decisions. We examine how self-regulation theory can be applied to inform our understanding of decision-making processes within the context of genomic testing, a clinical arena in which individuals face complex risk information and potentially life-altering decisions. After presenting key principles of self-regulation, we present a genomic testing case example to illustrate how principles related to risk representations, approach and avoidance motivations, emotion regulation, defensive responses, temporal construals, and capacities such as numeric abilities can shape decisions and psychological responses during the genomic testing process. We conclude with implications for using self-regulation theory to advance science within genomic testing and opportunities for how this research can inform further developments in self-regulation theory. PMID:29225669

Self-Regulation Principles Underlying Risk Perception and Decision Making within the Context of Genomic Testing.

Science.gov (United States)

Cameron, Linda D; Biesecker, Barbara Bowles; Peters, Ellen; Taber, Jennifer M; Klein, William M P

2017-05-01

Advances in theory and research on self-regulation and decision-making processes have yielded important insights into how cognitive, emotional, and social processes shape risk perceptions and risk-related decisions. We examine how self-regulation theory can be applied to inform our understanding of decision-making processes within the context of genomic testing, a clinical arena in which individuals face complex risk information and potentially life-altering decisions. After presenting key principles of self-regulation, we present a genomic testing case example to illustrate how principles related to risk representations, approach and avoidance motivations, emotion regulation, defensive responses, temporal construals, and capacities such as numeric abilities can shape decisions and psychological responses during the genomic testing process. We conclude with implications for using self-regulation theory to advance science within genomic testing and opportunities for how this research can inform further developments in self-regulation theory.

Mach's holographic principle

International Nuclear Information System (INIS)

Khoury, Justin; Parikh, Maulik

2009-01-01

Mach's principle is the proposition that inertial frames are determined by matter. We put forth and implement a precise correspondence between matter and geometry that realizes Mach's principle. Einstein's equations are not modified and no selection principle is applied to their solutions; Mach's principle is realized wholly within Einstein's general theory of relativity. The key insight is the observation that, in addition to bulk matter, one can also add boundary matter. Given a space-time, and thus the inertial frames, we can read off both boundary and bulk stress tensors, thereby relating matter and geometry. We consider some global conditions that are necessary for the space-time to be reconstructible, in principle, from bulk and boundary matter. Our framework is similar to that of the black hole membrane paradigm and, in asymptotically anti-de Sitter space-times, is consistent with holographic duality.

Ionic secondary emission SIMS principles and instrumentation

International Nuclear Information System (INIS)

Darque-Ceretti, E.; Migeon, H.N.; Aucouturier, M.

1998-01-01

The ionic analysis by secondary emission (SIMS) is one of material analysis based on the ions bombardment. That is micro-analysis method in taking into account that the dimensions of the analysed volume are under the micrometer. This paper details in a first part some ionic secondary emission principle to introduce a description of the instrumentation: microprobe, ions production, spectrometers. (A.L.B.)

Bounds and maximum principles for the solution of the linear transport equation

International Nuclear Information System (INIS)

Larsen, E.W.

1981-01-01

Pointwise bounds are derived for the solution of time-independent linear transport problems with surface sources in convex spatial domains. Under specified conditions, upper bounds are derived which, as a function of position, decrease with distance from the boundary. Also, sufficient conditions are obtained for the existence of maximum and minimum principles, and a counterexample is given which shows that such principles do not always exist

Cosmological principle

International Nuclear Information System (INIS)

Wesson, P.S.

1979-01-01

The Cosmological Principle states: the universe looks the same to all observers regardless of where they are located. To most astronomers today the Cosmological Principle means the universe looks the same to all observers because density of the galaxies is the same in all places. A new Cosmological Principle is proposed. It is called the Dimensional Cosmological Principle. It uses the properties of matter in the universe: density (rho), pressure (p), and mass (m) within some region of space of length (l). The laws of physics require incorporation of constants for gravity (G) and the speed of light (C). After combining the six parameters into dimensionless numbers, the best choices are: 8πGl 2 rho/c 2 , 8πGl 2 rho/c 4 , and 2 Gm/c 2 l (the Schwarzchild factor). The Dimensional Cosmological Principal came about because old ideas conflicted with the rapidly-growing body of observational evidence indicating that galaxies in the universe have a clumpy rather than uniform distribution

First-principles study on the electronic structure, phonons and optical properties of LaB_6 under high-pressure

International Nuclear Information System (INIS)

Chao, Luomeng; Bao, Lihong; Wei, Wei; O, Tegus; Zhang, Zhidong

2016-01-01

The electronic structure, phonons and optical properties of LaB_6 compound under different pressure have been studied by first-principles calculation. The electronic structure calculation shows that the d band along the M-Γ direction of the Brillouin zone moves up with increasing pressure and the band minimum is above the Fermi level at 45 GPa. The pressure-induced charge transfer from La to B atoms is reflected in the upshift of d band along the M-Γ direction with pressure. The calculated phonon dispersion curve at zero pressure is in good agreement with the experimental results. However, the phonon dispersion under high pressure does not show any information about the phase transition at 10 GPa, which was reported previously. The acoustic and optical phonon modes harden all the way with increasing pressure. In addition, the dielectric function is in accordance with the Drude model in the pressure range of 0 GPa–35 GPa and follows the Lorentz model at 45 GPa. The LaB_6 compound exhibits better visible light transmittance performance with the increasing pressure in the range of 0 GPa–35 GPa and visible light transmittance peak would be shifted towards ultraviolet region. - Highlights: • Physical properties of LaB_6 under high pressure have been theoretically studied. • Predict an electronic topological transition occurs at 45 GPa for LaB_6. • Predict a pressure-induced charge transfer from La to B atoms. • The phonon modes at Γ point show an increasing trend with increasing pressure. • The LaB_6 exhibits better heat-shielding performance with the increasing pressure.

Monte Carlo principles and applications

Energy Technology Data Exchange (ETDEWEB)

Raeside, D E [Oklahoma Univ., Oklahoma City (USA). Health Sciences Center

1976-03-01

The principles underlying the use of Monte Carlo methods are explained, for readers who may not be familiar with the approach. The generation of random numbers is discussed, and the connection between Monte Carlo methods and random numbers is indicated. Outlines of two well established Monte Carlo sampling techniques are given, together with examples illustrating their use. The general techniques for improving the efficiency of Monte Carlo calculations are considered. The literature relevant to the applications of Monte Carlo calculations in medical physics is reviewed.

Principles of modern digital design

CERN Document Server

Lala, Parag K

2007-01-01

A major objective of this book is to fill the gap between traditional logic design principles and logic design/optimization techniques used in practice. Over the last two decades several techniques for computer-aided design and optimization of logic circuits have been developed. However, underlying theories of these techniques are inadequately covered or not covered at all in undergraduate text books. This book covers not only the ""classical"" material found in current text books but also selected materials that modern logic designers need to be familiar with.

Computational modeling identifies key gene regulatory interactions underlying phenobarbital-mediated tumor promotion

Science.gov (United States)

Luisier, Raphaëlle; Unterberger, Elif B.; Goodman, Jay I.; Schwarz, Michael; Moggs, Jonathan; Terranova, Rémi; van Nimwegen, Erik

2014-01-01

Gene regulatory interactions underlying the early stages of non-genotoxic carcinogenesis are poorly understood. Here, we have identified key candidate regulators of phenobarbital (PB)-mediated mouse liver tumorigenesis, a well-characterized model of non-genotoxic carcinogenesis, by applying a new computational modeling approach to a comprehensive collection of in vivo gene expression studies. We have combined our previously developed motif activity response analysis (MARA), which models gene expression patterns in terms of computationally predicted transcription factor binding sites with singular value decomposition (SVD) of the inferred motif activities, to disentangle the roles that different transcriptional regulators play in specific biological pathways of tumor promotion. Furthermore, transgenic mouse models enabled us to identify which of these regulatory activities was downstream of constitutive androstane receptor and β-catenin signaling, both crucial components of PB-mediated liver tumorigenesis. We propose novel roles for E2F and ZFP161 in PB-mediated hepatocyte proliferation and suggest that PB-mediated suppression of ESR1 activity contributes to the development of a tumor-prone environment. Our study shows that combining MARA with SVD allows for automated identification of independent transcription regulatory programs within a complex in vivo tissue environment and provides novel mechanistic insights into PB-mediated hepatocarcinogenesis. PMID:24464994

"How do I say that?": Using communication principles to enhance medication therapy management instruction.

Science.gov (United States)

Denvir, Paul M; Cardone, Katie E; Parker, Wendy M; Cerulli, Jennifer

2018-02-01

Medication therapy management (MTM) is a comprehensive, patient-centered approach to improving medication use, reducing the risk of adverse events and improving medication adherence. Given the service delivery model and required outputs of MTM services, communication skills are of utmost importance. The objectives of this study were to identify and describe communication principles and instructional practices to enhance MTM training. Drawing on formative assessment data from interviews of both pharmacy educators and alumni, this article identifies and describes communication principles and instructional practices that pharmacy educators can use to enhance MTM training initiatives to develop student communication strategies. Analysis revealed five key communication challenges of MTM service delivery, two communication principles that pharmacy teachers and learners can use to address those challenges, and a range of specific strategies, derived from communication principles, that students can use when challenges emerge. Implications of the analysis for pharmacy educators and researchers are described. Proactive communication training provided during MTM advanced pharmacy practice experiences enabled students to apply the principles and instructional strategies to specific patient interactions during the advanced pharmacy practice experiences and in their post-graduation practice settings. Copyright © 2017 Elsevier Inc. All rights reserved.

Theoretical principles and practice of EU regional policy monitoring

Directory of Open Access Journals (Sweden)

Viktoriia Olіinyk

2014-09-01

Full Text Available The paper explores the practice of monitoring and evaluating regional development policy in the European Union, as well as impact thereof on key indicators of economic and social development both in separate regions and in the EU as a whole. The authors analyzed developments in the regional policy monitoring practice, while also identified peculiarities characteristic of the monitoring process regarding implementation of development programmes and determined main stages of evaluation. The paper specifies basic difficulties in setting up the system of monitoring and evaluating achievement of objectives and coordination of regional programmes. The authors described major disparity in economic and social development of the EU Member States under their development programmes as well as determined main indicators of EU regional disparities. Principles, instruments and mechanisms for monitoring EU regional policy were also defined. The paper analyzes changes in the EU regional development paradigm focusing on the priorities for concentrating financial resources and instruments in terms of cohesion policy

The precautionary principle as a rational decision criterion; Foere var-prinsippet som rasjonelt beslutningsgrunnlag

Energy Technology Data Exchange (ETDEWEB)

Hovi, Jon

2001-12-01

The paper asks if the precautionary principle may be seen as a rational decision criterion. Six main questions are discussed. 1. Does the principle basically represent a particular set of political options or is it a genuine decision criterion? 2. If it is the latter, can it be reduced to any of the existing criteria for decision making under uncertainty? 3. In what kinds of situation is the principle applicable? 4. What is the relation between the precautionary principle and other principles for environmental regulation? 5. How plausible is the principle's claim that the burden of proof should be reversed? 6. Do the proponents of environmental regulation carry no burden of proof at all? A main conclusion is that, for now at least, the principle contains too many unclear elements to satisfy the requirements of precision and consistency that should reasonably be satisfied by a rational decision criterion. (author)

Choice of mineral fertilizer substitution principle strongly influences LCA environmental benefits of nutrient cycling in the agri-food system.

Science.gov (United States)

Hanserud, Ola Stedje; Cherubini, Francesco; Øgaard, Anne Falk; Müller, Daniel B; Brattebø, Helge

2018-02-15

Increased nutrient cycling in the agri-food system is a way to achieve a healthier nutrient stewardship and more sustainable food production. In life cycle assessment (LCA) studies, use of recycled fertilizer products is often credited by the substitution method, which subtracts the environmental burdens associated with avoided production of mineral fertilizer from the system under study. The environmental benefits from avoided fertilizer production can make an important contribution to the results, but different calculation principles and often implicit assumptions are used to estimate the amount of avoided mineral fertilizer. This may hinder comparisons between studies. The present study therefore examines how the choice of substitution principles influences LCA results. Three different substitution principles, called one-to-one, maintenance, and adjusted maintenance, are identified, and we test the importance of these in a case study on cattle slurry management. We show that the inventory of avoided mineral fertilizer varies greatly when the different principles are applied, with strong influences on two-thirds of LCA impact categories. With the one-to-one principle, there is a risk of systematically over-estimating the environmental benefits from nutrient cycling. In a sensitivity analysis we show that the difference between the principles is closely related to the application rate and levels of residual nutrients in the soil. We recommend that LCA practitioners first and foremost state and justify the substitution method they use, in order to increase transparency and comparability with other studies. Copyright © 2017 Elsevier B.V. All rights reserved.

Computer-based teaching module design: principles derived from learning theories.

Science.gov (United States)

Lau, K H Vincent

2014-03-01

The computer-based teaching module (CBTM), which has recently gained prominence in medical education, is a teaching format in which a multimedia program serves as a single source for knowledge acquisition rather than playing an adjunctive role as it does in computer-assisted learning (CAL). Despite empirical validation in the past decade, there is limited research into the optimisation of CBTM design. This review aims to summarise research in classic and modern multimedia-specific learning theories applied to computer learning, and to collapse the findings into a set of design principles to guide the development of CBTMs. Scopus was searched for: (i) studies of classic cognitivism, constructivism and behaviourism theories (search terms: 'cognitive theory' OR 'constructivism theory' OR 'behaviourism theory' AND 'e-learning' OR 'web-based learning') and their sub-theories applied to computer learning, and (ii) recent studies of modern learning theories applied to computer learning (search terms: 'learning theory' AND 'e-learning' OR 'web-based learning') for articles published between 1990 and 2012. The first search identified 29 studies, dominated in topic by the cognitive load, elaboration and scaffolding theories. The second search identified 139 studies, with diverse topics in connectivism, discovery and technical scaffolding. Based on their relative representation in the literature, the applications of these theories were collapsed into a list of CBTM design principles. Ten principles were identified and categorised into three levels of design: the global level (managing objectives, framing, minimising technical load); the rhetoric level (optimising modality, making modality explicit, scaffolding, elaboration, spaced repeating), and the detail level (managing text, managing devices). This review examined the literature in the application of learning theories to CAL to develop a set of principles that guide CBTM design. Further research will enable educators to

Conversation principles and second language utterances

Directory of Open Access Journals (Sweden)

Kaburise, Phyllis

2007-12-01

Full Text Available Conversation principles, such as those of Grice (1957, 1968, 1975, Austin (1962, Searle (1962, 1969 are formulated to enable interlocutors to interact meaningfully, in a linguistic project. Non-observance and flouting of these principles occur regularly in the verbal behaviours of users of a language, indeed, sophisticated users of a language, sometimes deliberately go against these norms, as stylistic devices in their output. When such non-conformities occur, hearers and readers resort to implicatures, maxims, inferences and their general world knowledge to interpret an utterance. Although the decision to observe some, and not all of the principles during a linguistic encounter, may seem to be taken casually, it is the contention of this paper that such decisions are made deliberately, particularly, by users of a second language. This paper attempts to identify the selection processes involved in the creation of some utterances produced by Ghanaian and Tshivenda second language users of English, using Grice’s verbal interaction maxims. The discussion will focus on the tension between semantic and pragmatic meaning, the factors involved in the creation of linguistic meaning and the role that interaction requirements such as Grice’s conversational maxims and the concept of a New Englishes approach to language play in the creation of some second language utterances.

The free-energy principle: a unified brain theory?

Science.gov (United States)

Friston, Karl

2010-02-01

A free-energy principle has been proposed recently that accounts for action, perception and learning. This Review looks at some key brain theories in the biological (for example, neural Darwinism) and physical (for example, information theory and optimal control theory) sciences from the free-energy perspective. Crucially, one key theme runs through each of these theories - optimization. Furthermore, if we look closely at what is optimized, the same quantity keeps emerging, namely value (expected reward, expected utility) or its complement, surprise (prediction error, expected cost). This is the quantity that is optimized under the free-energy principle, which suggests that several global brain theories might be unified within a free-energy framework.

First-principles data-driven discovery of transition metal oxides for artificial photosynthesis

Science.gov (United States)

Yan, Qimin

We develop a first-principles data-driven approach for rapid identification of transition metal oxide (TMO) light absorbers and photocatalysts for artificial photosynthesis using the Materials Project. Initially focusing on Cr, V, and Mn-based ternary TMOs in the database, we design a broadly-applicable multiple-layer screening workflow automating density functional theory (DFT) and hybrid functional calculations of bulk and surface electronic and magnetic structures. We further assess the electrochemical stability of TMOs in aqueous environments from computed Pourbaix diagrams. Several promising earth-abundant low band-gap TMO compounds with desirable band edge energies and electrochemical stability are identified by our computational efforts and then synergistically evaluated using high-throughput synthesis and photoelectrochemical screening techniques by our experimental collaborators at Caltech. Our joint theory-experiment effort has successfully identified new earth-abundant copper and manganese vanadate complex oxides that meet highly demanding requirements for photoanodes, substantially expanding the known space of such materials. By integrating theory and experiment, we validate our approach and develop important new insights into structure-property relationships for TMOs for oxygen evolution photocatalysts, paving the way for use of first-principles data-driven techniques in future applications. This work is supported by the Materials Project Predictive Modeling Center and the Joint Center for Artificial Photosynthesis through the U.S. Department of Energy, Office of Basic Energy Sciences, Materials Sciences and Engineering Division, under Contract No. DE-AC02-05CH11231. Computational resources also provided by the Department of Energy through the National Energy Supercomputing Center.

High-Order Hamilton's Principle and the Hamilton's Principle of High-Order Lagrangian Function

International Nuclear Information System (INIS)

Zhao Hongxia; Ma Shanjun

2008-01-01

In this paper, based on the theorem of the high-order velocity energy, integration and variation principle, the high-order Hamilton's principle of general holonomic systems is given. Then, three-order Lagrangian equations and four-order Lagrangian equations are obtained from the high-order Hamilton's principle. Finally, the Hamilton's principle of high-order Lagrangian function is given.

Using Cartoons to Transfer Knowledge Concerning the Principles of Work Disability Prevention Among Stakeholders.

Science.gov (United States)

Labrecque, Marie-Elise; Coutu, Marie-France; Durand, Marie-José; Fassier, Jean-Baptiste; Loisel, Patrick

2016-06-01

Purpose This study assesses how well two cartoons transfer knowledge of principles of work disability prevention among stakeholders, according to their level of experience. We also document stakeholders' perceptions of the usefulness of the cartoons. Method We performed a descriptive study. Two groups of stakeholders were recruited: (1) experienced (working for more than 2 years in work disability), (2) non-experienced (in training). A self-administered questionnaire with open-ended questions documented stakeholders' understanding of each cartoon box and their perception of the possible usefulness of the cartoons. We transformed qualitative responses into quantitative responses for descriptive purposes. We performed independent t tests to compare the groups' level of understanding, and content analysis for the perception of usefulness. Results Overall, 149 stakeholders (50 experienced and 99 non-experienced) participated and identified 79.4 and 61.4 % of all principles presented in each of the two cartoons respectively. Experienced stakeholders identified more principles compared to non-experienced stakeholders (p = 0.007). Both cartoons were perceived to be useful for knowledge transfer. Conclusions Principles were generally well identified in the cartoons by all participants. Cartoons can be used as an effective tool among stakeholders to achieve a common understanding in order to coordinate their actions.

Radiation protection principles applied to conventional industries producing deleterious environmental effects

International Nuclear Information System (INIS)

Tadmor, J.

1980-01-01

Comparison of the radiation protection standards, for the population at large, with the conventional pollutants ambient standards, reveals differences in basic principles which result in more relaxed ambient standards for conventional pollutants and consequently, the penalization of the nuclear industry, due to the increased cost of its safety measures. It is proposed that radiation protection principles should be used as a prototype for pollutants having harmful environmental effects and that radiation health physicists should be active in the application of these principles of population protection. A case study of atmospheric release of SO 2 , under different conditions, is analyzed, to emphasize the importance of consideration of the size of the exposed population. (H.K.)

The common European flexicurity principles

DEFF Research Database (Denmark)

Mailand, Mikkel

2010-01-01

This article analyses the decision-making process underlying the adoption of common EU flexicurity principles. Supporters of the initiative succeeded in convincing the sceptics one by one; the change of government in France and the last-minute support of the European social partner organizations...... were instrumental in this regard. However, the critics succeeded in weakening the initially strong focus on the transition from job security to employment security and the divisions between insiders and outsiders in the labour market. In contrast to some decision-making on the European Employment...

Corrosion principles and surface modification

International Nuclear Information System (INIS)

Kruger, J.

1982-01-01

This chapter examines the important strategies provided by the newer ideas of corrosion science and engineering that surface modification techniques must utilize to help prevent corrosion, especially the most damaging kind of aqueous corrosion, localized corrosion. Provides a brief introduction to the principles underlying the phenomenon of corrosion in order to use them to discuss surface modification strategies to combat corrosion. Discusses the electrochemistry of corrosion; the thermodynamics of corrosion; the kinetics of corrosion; thermodynamic strategies; and kinetic strategies (formation of more protective passive films; resistance to breakdown; ductility; repassivation)

PROFIT-MAXIMIZING PRINCIPLES, INSTRUCTIONAL UNITS FOR VOCATIONAL AGRICULTURE.

Science.gov (United States)

BARKER, RICHARD L.

THE PURPOSE OF THIS GUIDE IS TO ASSIST VOCATIONAL AGRICULTURE TEACHERS IN STIMULATING JUNIOR AND SENIOR HIGH SCHOOL STUDENT THINKING, UNDERSTANDING, AND DECISION MAKING AS ASSOCIATED WITH PROFIT-MAXIMIZING PRINCIPLES OF FARM OPERATION FOR USE IN FARM MANAGEMENT. IT WAS DEVELOPED UNDER A U.S. OFFICE OF EDUCATION GRANT BY TEACHER-EDUCATORS, A FARM…

Useful Principles in Plant Excellence Promotion

International Nuclear Information System (INIS)

Kavsek, D.; Bozin, B.

2002-01-01

This presentation offers a discussion of some principles identified from a review of significant industry events that affected the safety or reliability of a large number of nuclear power plants worldwide. Over the years of operation, a number of events have occurred in nuclear power plants that have involved problems in human performance. A review of these and other significant events has identified recurring weaknesses in plant safety culture and policy and procedure weaknesses. Focusing attention on strengthening relevant processes can help plants avoid similar significant events. Events continue to occur because the lessons learned from industry and plant operating experience are ineffectively used. In some cases, industry events have been communicated to the personnel of the plant in question, but without a thorough explanation of the lessons learned and applicability to the plant. The corrective actions identified have sometimes been limited in scope and have not fully addressed generic issues. The review and implementation of corrective actions for in-house events have sometimes been inadequate to prevent recurrences. An effective operating experience program can significantly reduce the potential for recurring events. The value of learning and applying the knowledge gained from operating experience should be an integral part of plant culture and promoted as an expectation. When operating experience is reviewed, generic issues and causal factors should be explored, rather than focusing on the unique problems that led to a specific event. Lessons learned and applicability to the plant must be clearly identified, corrective action taken, and changes thoroughly communicated to the plant personnel. Their understanding of the changes and the reasons for them should then be confirmed. The following principles will be discussed in this presentation: recognizing conditions during evolutions, promoting teamwork, recognizing fundamental knowledge weaknesses

An evolutionary reduction principle for mutation rates at multiple Loci.

Science.gov (United States)

Altenberg, Lee

2011-06-01

A model of mutation rate evolution for multiple loci under arbitrary selection is analyzed. Results are obtained using techniques from Karlin (Evolutionary Biology, vol. 14, pp. 61-204, 1982) that overcome the weak selection constraints needed for tractability in prior studies of multilocus event models.A multivariate form of the reduction principle is found: reduction results at individual loci combine topologically to produce a surface of mutation rate alterations that are neutral for a new modifier allele. New mutation rates survive if and only if they fall below this surface-a generalization of the hyperplane found by Zhivotovsky et al. (Proc. Natl. Acad. Sci. USA 91, 1079-1083, 1994) for a multilocus recombination modifier. Increases in mutation rates at some loci may evolve if compensated for by decreases at other loci. The strength of selection on the modifier scales in proportion to the number of germline cell divisions, and increases with the number of loci affected. Loci that do not make a difference to marginal fitnesses at equilibrium are not subject to the reduction principle, and under fine tuning of mutation rates would be expected to have higher mutation rates than loci in mutation-selection balance.Other results include the nonexistence of 'viability analogous, Hardy-Weinberg' modifier polymorphisms under multiplicative mutation, and the sufficiency of average transmission rates to encapsulate the effect of modifier polymorphisms on the transmission of loci under selection. A conjecture is offered regarding situations, like recombination in the presence of mutation, that exhibit departures from the reduction principle. Constraints for tractability are: tight linkage of all loci, initial fixation at the modifier locus, and mutation distributions comprising transition probabilities of reversible Markov chains.

The principle of relativity and the special relativity triple

International Nuclear Information System (INIS)

Guo Hanying; Wu Hongtu; Zhou Bin

2009-01-01

Based on the principle of relativity and the postulate on universal invariant constants (c,l) as well as Einstein's isotropy conditions, three kinds of special relativity form a triple with a common Lorentz group as isotropy group under full Umov-Weyl-Fock-Lorentz transformations among inertial motions

The improving of methodological principles of enterprise competitiveness management under the crisis

Directory of Open Access Journals (Sweden)

Marina Dyadyuk

2016-12-01

Full Text Available The purpose of this research is methodological bases improving and forming of practical tools for enterprise competitiveness management under the crisis. The specific features of the competitive environment of enterprises in Ukraine under the global and national crisis are researched in the article. From this it is concluded that any enterprise must have a greater degree of flexibility than in periods of stability or economic growth for obtaining and maintaining of competitive advantages in the current period of global instability. Flexibility and adaptability of the economic system is the main prerequisite for obtaining and developing of enterprise competitive advantages and stem component of competitiveness. We identified and characterized the methodological components of adaptive management process on the base of systematic approach and with taking into account views of scientists. The obtained scientific results are the basis for conceptual model of integrated system of enterprise adaptive management in terms of dynamic and uncertainty environment. We propose to implement this kind of control on three levels: strategic (preventive management, functionality (tactical management and operational (symptomatic management on the base of analyzing economically grounded views and existing positions. It all together will ensure effective adaptation at the macroeconomic, meso and micro levels of management. The main purpose of the proposed integrated management system is ensuring the stability and integrity of enterprises activity in terms of variability and uncertainty of the environment. The implementation of such management system provides the enterprise with certain competitive advantages. It will allow to Ukrainian enterprises maintaining the competitive position in unfavorable external conditions, but also maintaining and improving the competitiveness.

TAMING TROJAN HORSES: IDENTIFYING AND MITIGATING CORPORATE SOCIAL RESPONSIBILITY RISKS

OpenAIRE

P. P. M. A. R. HEUGENS; N. A. DENTCHEV

2007-01-01

textabstractOrganizations are exposed to increasing pressures from their constituents to integrate corporate social responsibility (CSR) principles into their ongoing business practices. But accepting new and potentially open-ended commitments is not a harmless exercise, and companies may well expose themselves to serious risks when embracing such principles. To identify these risks, we conducted two naturalistic studies: one exploratory, the other corroborative. The results show that CSR ado...

A Variation on Uncertainty Principle and Logarithmic Uncertainty Principle for Continuous Quaternion Wavelet Transforms

Directory of Open Access Journals (Sweden)

Mawardi Bahri

2017-01-01

Full Text Available The continuous quaternion wavelet transform (CQWT is a generalization of the classical continuous wavelet transform within the context of quaternion algebra. First of all, we show that the directional quaternion Fourier transform (QFT uncertainty principle can be obtained using the component-wise QFT uncertainty principle. Based on this method, the directional QFT uncertainty principle using representation of polar coordinate form is easily derived. We derive a variation on uncertainty principle related to the QFT. We state that the CQWT of a quaternion function can be written in terms of the QFT and obtain a variation on uncertainty principle related to the CQWT. Finally, we apply the extended uncertainty principles and properties of the CQWT to establish logarithmic uncertainty principles related to generalized transform.

Aggregator: a machine learning approach to identifying MEDLINE articles that derive from the same underlying clinical trial.

Science.gov (United States)

Shao, Weixiang; Adams, Clive E; Cohen, Aaron M; Davis, John M; McDonagh, Marian S; Thakurta, Sujata; Yu, Philip S; Smalheiser, Neil R

2015-03-01

It is important to identify separate publications that report outcomes from the same underlying clinical trial, in order to avoid over-counting these as independent pieces of evidence. We created positive and negative training sets (comprised of pairs of articles reporting on the same condition and intervention) that were, or were not, linked to the same clinicaltrials.gov trial registry number. Features were extracted from MEDLINE and PubMed metadata; pairwise similarity scores were modeled using logistic regression. Article pairs from the same trial were identified with high accuracy (F1 score=0.843). We also created a clustering tool, Aggregator, that takes as input a PubMed user query for RCTs on a given topic, and returns article clusters predicted to arise from the same clinical trial. Although painstaking examination of full-text may be needed to be conclusive, metadata are surprisingly accurate in predicting when two articles derive from the same underlying clinical trial. Copyright © 2014 Elsevier Inc. All rights reserved.

Biomedical engineering principles

CERN Document Server

Ritter, Arthur B; Valdevit, Antonio; Ascione, Alfred N

2011-01-01

Introduction: Modeling of Physiological ProcessesCell Physiology and TransportPrinciples and Biomedical Applications of HemodynamicsA Systems Approach to PhysiologyThe Cardiovascular SystemBiomedical Signal ProcessingSignal Acquisition and ProcessingTechniques for Physiological Signal ProcessingExamples of Physiological Signal ProcessingPrinciples of BiomechanicsPractical Applications of BiomechanicsBiomaterialsPrinciples of Biomedical Capstone DesignUnmet Clinical NeedsEntrepreneurship: Reasons why Most Good Designs Never Get to MarketAn Engineering Solution in Search of a Biomedical Problem

Demonstration of Human-Autonomy Teaming Principles

Science.gov (United States)

Shively, Robert Jay

2016-01-01

Known problems with automation include lack of mode awareness, automation brittleness, and risk of miscalibrated trust. Human-Autonomy Teaming (HAT) is essential for improving these problems. We have identified some critical components of HAT and ran a part-task study to introduce these components to a ground station that supports flight following of multiple aircraft. Our goal was to demonstrate, evaluate, and refine HAT principles. This presentation provides a brief summary of the study and initial findings.

The genetic difference principle.

Science.gov (United States)

Farrelly, Colin

2004-01-01

In the newly emerging debates about genetics and justice three distinct principles have begun to emerge concerning what the distributive aim of genetic interventions should be. These principles are: genetic equality, a genetic decent minimum, and the genetic difference principle. In this paper, I examine the rationale of each of these principles and argue that genetic equality and a genetic decent minimum are ill-equipped to tackle what I call the currency problem and the problem of weight. The genetic difference principle is the most promising of the three principles and I develop this principle so that it takes seriously the concerns of just health care and distributive justice in general. Given the strains on public funds for other important social programmes, the costs of pursuing genetic interventions and the nature of genetic interventions, I conclude that a more lax interpretation of the genetic difference principle is appropriate. This interpretation stipulates that genetic inequalities should be arranged so that they are to the greatest reasonable benefit of the least advantaged. Such a proposal is consistent with prioritarianism and provides some practical guidance for non-ideal societies--that is, societies that do not have the endless amount of resources needed to satisfy every requirement of justice.

Variational principles for collective motion: Relation between invariance principle of the Schroedinger equation and the trace variational principle

International Nuclear Information System (INIS)

Klein, A.; Tanabe, K.

1984-01-01

The invariance principle of the Schroedinger equation provides a basis for theories of collective motion with the help of the time-dependent variational principle. It is formulated here with maximum generality, requiring only the motion of intrinsic state in the collective space. Special cases arise when the trial vector is a generalized coherent state and when it is a uniform superposition of collective eigenstates. The latter example yields variational principles uncovered previously only within the framework of the equations of motion method. (orig.)

Stiffness Parameter Design of Suspension Element of Under-Chassis-Equipment for A Rail Vehicle

Science.gov (United States)

Ma, Menglin; Wang, Chengqiang; Deng, Hai

2017-06-01

According to the frequency configuration requirements of the vibration of railway under-chassis-equipment, the three- dimension stiffness of the suspension elements of under-chassis-equipment is designed based on the static principle and dynamics principle. The design results of the concrete engineering case show that, compared with the design method based on the static principle, the three- dimension stiffness of the suspension elements designed by the dynamic principle design method is more uniform. The frequency and decoupling degree analysis show that the calculation frequency of under-chassis-equipment under the two design methods is basically the same as the predetermined frequency. Compared with the design method based on the static principle, the design method based on the dynamic principle is adopted. The decoupling degree can be kept high, and the coupling vibration of the corresponding vibration mode can be reduced effectively, which can effectively reduce the fatigue damage of the key parts of the hanging element.

Quasi-static responses and variational principles in gradient plasticity

Science.gov (United States)

Nguyen, Quoc-Son

2016-12-01

Gradient models have been much discussed in the literature for the study of time-dependent or time-independent processes such as visco-plasticity, plasticity and damage. This paper is devoted to the theory of Standard Gradient Plasticity at small strain. A general and consistent mathematical description available for common time-independent behaviours is presented. Our attention is focussed on the derivation of general results such as the description of the governing equations for the global response and the derivation of related variational principles in terms of the energy and the dissipation potentials. It is shown that the quasi-static response under a loading path is a solution of an evolution variational inequality as in classical plasticity. The rate problem and the rate minimum principle are revisited. A time-discretization by the implicit scheme of the evolution equation leads to the increment problem. An increment of the response associated with a load increment is a solution of a variational inequality and satisfies also a minimum principle if the energy potential is convex. The increment minimum principle deals with stables solutions of the variational inequality. Some numerical methods are discussed in view of the numerical simulation of the quasi-static response.

Morozov-type discrepancy principle for nonlinear ill-posed problems ...

Indian Academy of Sciences (India)

For proving the existence of a regularization parameter under a Morozov-type discrepancy principle for Tikhonov regularization of nonlinear ill-posed problems, it is required to impose additional nonlinearity assumptions on the forward operator. Lipschitz continuity of the Freéchet derivative and requirement of the Lipschitz ...

Some special features of the le chatelier-braun principle

Science.gov (United States)

Nesis, E. I.; Skibin, Yu. N.

2000-07-01

The relaxation reaction of a system that follows from the Le Chatelier-Braun principle and weakens the result of an external influence turns out to be more intense under a complex action. A method for quantitative determination of the weakening effect for simple and complex actions is suggested.

Morozov-type discrepancy principle for nonlinear ill-posed problems ...

Indian Academy of Sciences (India)

2016-08-26

Aug 26, 2016 ... For proving the existence of a regularization parameter under a Morozov-type discrepancy principle for Tikhonov regularization of nonlinear ill-posed problems, it is required to impose additional nonlinearity assumptions on the forward operator. Lipschitz continuity of the Freéchet derivative and requirement ...

Core principles of evolutionary medicine

Science.gov (United States)

Grunspan, Daniel Z; Nesse, Randolph M; Barnes, M Elizabeth; Brownell, Sara E

2018-01-01

Abstract Background and objectives Evolutionary medicine is a rapidly growing field that uses the principles of evolutionary biology to better understand, prevent and treat disease, and that uses studies of disease to advance basic knowledge in evolutionary biology. Over-arching principles of evolutionary medicine have been described in publications, but our study is the first to systematically elicit core principles from a diverse panel of experts in evolutionary medicine. These principles should be useful to advance recent recommendations made by The Association of American Medical Colleges and the Howard Hughes Medical Institute to make evolutionary thinking a core competency for pre-medical education. Methodology The Delphi method was used to elicit and validate a list of core principles for evolutionary medicine. The study included four surveys administered in sequence to 56 expert panelists. The initial open-ended survey created a list of possible core principles; the three subsequent surveys winnowed the list and assessed the accuracy and importance of each principle. Results Fourteen core principles elicited at least 80% of the panelists to agree or strongly agree that they were important core principles for evolutionary medicine. These principles over-lapped with concepts discussed in other articles discussing key concepts in evolutionary medicine. Conclusions and implications This set of core principles will be helpful for researchers and instructors in evolutionary medicine. We recommend that evolutionary medicine instructors use the list of core principles to construct learning goals. Evolutionary medicine is a young field, so this list of core principles will likely change as the field develops further. PMID:29493660

[The precautionary principle: advantages and risks].

Science.gov (United States)

Tubiana, M

2001-04-01

The extension of the precautionary principle to the field of healthcare is the social response to two demands of the population: improved health safety and the inclusion of an informed public in the decision-making process. The necessary balance between cost (treatment-induced risk) and benefit (therapeutic effect) underlies all healthcare decisions. An underestimation or an overestimation of cost, i.e. risk, is equally harmful in public healthcare. A vaccination should be prescribed when its beneficial effect outweighs its inevitable risk. Mandatory vaccination, such as in the case of the Hepatitis B virus, is a health policy requiring some courage because those who benefit will never be aware of its positive effect while those who are victims of the risk could resort to litigation. Defense against such accusations requires an accurate assessment of risk and benefit, which underlines the importance of expertise. Even within the framework of the precautionary principle, it is impossible to act without knowledge, or at least a plausible estimation, of expected effects. Recent affairs (blood contamination, transmissible spongiform encephalitis by growth hormone, and new variant of Creutzfeldt-Jacob disease) illustrate that in such cases the precautionary principle would have had limited impact and it is only when enough knowledge was available that effective action could be taken. Likewise, in current debates concerning the possible risks of electromagnetic fields, cellular phones and radon, research efforts must be given priority. The general public understands intuitively the concept of cost and benefit. For example, the possible health risks of oral contraceptives and hormone replacement therapy were not ignored, but the public has judged that their advantages justify the risk. Estimating risk and benefit and finding a balance between risk and preventive measures could help avoid the main drawbacks of the precautionary principle, i.e. inaction and refusal of

Use and validity of principles of extremum of entropy production in the study of complex systems

International Nuclear Information System (INIS)

Heitor Reis, A.

2014-01-01

It is shown how both the principles of extremum of entropy production, which are often used in the study of complex systems, follow from the maximization of overall system conductivities, under appropriate constraints. In this way, the maximum rate of entropy production (MEP) occurs when all the forces in the system are kept constant. On the other hand, the minimum rate of entropy production (mEP) occurs when all the currents that cross the system are kept constant. A brief discussion on the validity of the application of the mEP and MEP principles in several cases, and in particular to the Earth’s climate is also presented. -- Highlights: •The principles of extremum of entropy production are not first principles. •They result from the maximization of conductivities under appropriate constraints. •The conditions of their validity are set explicitly. •Some long-standing controversies are discussed and clarified

The certainty principle (review)

OpenAIRE

Arbatsky, D. A.

2006-01-01

The certainty principle (2005) allowed to conceptualize from the more fundamental grounds both the Heisenberg uncertainty principle (1927) and the Mandelshtam-Tamm relation (1945). In this review I give detailed explanation and discussion of the certainty principle, oriented to all physicists, both theorists and experimenters.

Fusion research principles

CERN Document Server

Dolan, Thomas James

2013-01-01

Fusion Research, Volume I: Principles provides a general description of the methods and problems of fusion research. The book contains three main parts: Principles, Experiments, and Technology. The Principles part describes the conditions necessary for a fusion reaction, as well as the fundamentals of plasma confinement, heating, and diagnostics. The Experiments part details about forty plasma confinement schemes and experiments. The last part explores various engineering problems associated with reactor design, vacuum and magnet systems, materials, plasma purity, fueling, blankets, neutronics

Applied predictive analytics principles and techniques for the professional data analyst

CERN Document Server

Abbott, Dean

2014-01-01

Learn the art and science of predictive analytics - techniques that get results Predictive analytics is what translates big data into meaningful, usable business information. Written by a leading expert in the field, this guide examines the science of the underlying algorithms as well as the principles and best practices that govern the art of predictive analytics. It clearly explains the theory behind predictive analytics, teaches the methods, principles, and techniques for conducting predictive analytics projects, and offers tips and tricks that are essential for successful predictive mode

Database principles programming performance

CERN Document Server

O'Neil, Patrick

2014-01-01

Database: Principles Programming Performance provides an introduction to the fundamental principles of database systems. This book focuses on database programming and the relationships between principles, programming, and performance.Organized into 10 chapters, this book begins with an overview of database design principles and presents a comprehensive introduction to the concepts used by a DBA. This text then provides grounding in many abstract concepts of the relational model. Other chapters introduce SQL, describing its capabilities and covering the statements and functions of the programmi

The normative basis of the Precautionary Principle

Energy Technology Data Exchange (ETDEWEB)

Schomberg, Rene von [European Commission, Directorate General for Research, Brussels (Belgium)

2006-09-15

particular sequence in an ideal world (e.g. from the political level downwards), practically the 'entry' stage can be at any level and those levels do not represent a hierarchy in any sense. Practices which were formerly not based on the precautionary principle may become based on the precautionary principle by discussions which arise at the science/policy interface. I conclude with an overall definition of the precautionary principle (rather than a specified definition of the precautionary principle for a particular area, such as the environment, human health or food safety) while remaining within the wide scope and limits of the recent rulings of the European Court of Justice, the broad EU endorsement of the European Guidelines on the precautionary principle, and international obligations under international Treaties such as those under the WTO and the UN. The definition contains all the normative dimensions discussed in this contribution: Where, following an assessment of available scientific information, there are reasonable grounds for concern for the possibility of adverse effects but scientific uncertainty persists, provisional risk management measures based on a broad cost/benefit analysis whereby priority will be given to human health and the environment, necessary to ensure the chosen high level of protection in the Community and proportionate to this level of protection, may be adopted, pending further scientific information for a more comprehensive risk assessment, without having to wait until the reality and seriousness of those adverse effects become fully apparent.

The normative basis of the Precautionary Principle

International Nuclear Information System (INIS)

Schomberg, Rene von

2006-01-01

sequence in an ideal world (e.g. from the political level downwards), practically the 'entry' stage can be at any level and those levels do not represent a hierarchy in any sense. Practices which were formerly not based on the precautionary principle may become based on the precautionary principle by discussions which arise at the science/policy interface. I conclude with an overall definition of the precautionary principle (rather than a specified definition of the precautionary principle for a particular area, such as the environment, human health or food safety) while remaining within the wide scope and limits of the recent rulings of the European Court of Justice, the broad EU endorsement of the European Guidelines on the precautionary principle, and international obligations under international Treaties such as those under the WTO and the UN. The definition contains all the normative dimensions discussed in this contribution: Where, following an assessment of available scientific information, there are reasonable grounds for concern for the possibility of adverse effects but scientific uncertainty persists, provisional risk management measures based on a broad cost/benefit analysis whereby priority will be given to human health and the environment, necessary to ensure the chosen high level of protection in the Community and proportionate to this level of protection, may be adopted, pending further scientific information for a more comprehensive risk assessment, without having to wait until the reality and seriousness of those adverse effects become fully apparent

A comparison of two different sound intensity measurement principles

DEFF Research Database (Denmark)

Jacobsen, Finn; de Bree, Hans-Elias

2005-01-01

, and compares the two measurement principles with particular regard to the sources of error in sound power determination. It is shown that the phase calibration of intensity probes that combine different transducers is very critical below 500 Hz if the measurement surface is very close to the source under test...

Bioassay-guided isolation of active principles from Nigerian medicinal plants identifies new trypanocides with low toxicity and no cross-resistance to diamidines and arsenicals.

Science.gov (United States)

Ebiloma, Godwin Unekwuojo; Igoli, John Ogbaji; Katsoulis, Evangelos; Donachie, Anne-Marie; Eze, Anthonius; Gray, Alexander Ian; de Koning, Harry P

2017-04-18

Leaves from the plant species studied herein are traditionally used in northern Nigeria against various protozoan infections. However, none of these herbal preparations have been standardized, nor have their toxicity to mammalian cells been investigated. In search of improved and non-toxic active antiprotozoal principles that are not cross-resistant with current anti-parasitics, we here report the results of the in vitro screening of extracts from seven selected medicinal plant species (Centrosema pubescens, Moringa oleifera, Tridax procumbens, Polyalthia longifolia, Newbouldia laevis, Eucalyptus maculate, Jathropha tanjorensis), used traditionally to treat kinetoplastid infections in Nigeria, and the isolation of their bioactive principles. To investigate the efficacies of medicinal plant extracts, and of compounds isolated therefrom, against kinetoplastid parasites, assess cross-resistance to existing chemotherapy, and assay their toxicity against mammalian cells in vitro. Plants were extracted with hexane, ethyl acetate and methanol. Active principles were isolated by bioassay-led fractionation, testing for trypanocidal activity, and identified using NMR and mass spectrometry. EC 50 values for their activity against wild-type and multi-drug resistant Trypanosoma brucei were obtained using the viability indicator dye resazurin. Seven medicinal plants were evaluated for activity against selected kinetoplastid parasites. The result shows that crude extracts and isolated active compounds from Polyalthia longifolia and Eucalyptus maculata, in particular, display promising activity against drug-sensitive and multi-drug resistant Trypanosoma brucei. The EC 50 value of a clerodane (16α-hydroxy-cleroda-3,13(14)-Z-dien-15,16-olide) isolated from Polyalthia longifolia was as low as 0.38µg/mL, while a triterpenoid (3β,13β-dihydroxy-urs-11-en-28-oic acid) isolated from Eucalyptus maculata displayed an EC 50 of 1.58µg/mL. None of the isolated compounds displayed toxicity

Social work in a society under pressure. Keeping professional principles and standards upright.

Directory of Open Access Journals (Sweden)

Willem Blok

2016-06-01

Full Text Available This article is based on the content and outcome of the 5th Annual International Conference on Social Work & Social Work Education in Leeuwarden, The Netherlands on February 5, 2016. It shows how Social Work is embedded in society, and describes the pressure of contemporary (international problems on society, and the way in which authorities respond to it. The article continues with a discussion of the answers given by the 200 conference participants on the question how social workers and social work educators could cope with this pressure without denying their international professional principles and standards.

Precautionary principle, economic and energy systems and social equity

International Nuclear Information System (INIS)

Carvalho, Joaquim Francisco de; Mercedes, Sonia Seger P.; Sauer, Ildo L.

2010-01-01

In this paper the precautionary principle is reviewed alongside the process of international implementation. Adoption of the precautionary principle is advocated to deal with energy choices as a mechanism to account for potential climate change impacts, notwithstanding the debate on scientific uncertainty on the links between solar activity, greenhouse gas concentration and climate. However, it is also recognized that the widespread application of the precautionary principle to energy choices does not seem to be taking place in the real world. Relevant concrete barriers are identified stemming from the intrinsic logic governing the hegemonic economic system, driving the energy choices by economic surplus and rent generation potential, the existence of social asymmetries inside and among societies as well as by the absence of democratic global governance mechanisms, capable of dealing with climate change issues. Such perception seems to have been reinforced by the outcome of the United Nations Climate Change Conference, held in Copenhagen in December 2009.

Methodological Challenges of Identifying Ultimate Land Use Changes Caused by Biofuel Production

DEFF Research Database (Denmark)

Wenzel, Henrik; Kløverpris, Jesper; Nielsen, Per Henning

2007-01-01

that is only poorly dealt with by LCA methods. Even though the use of land, or change of land cover and its eco-systems, is acknowledged to be a very important impact of human activities, a methodology for assessing this impact category has not yet  been properly developed within LCA. Some LCA scientists have...... looked into methods for assessing the impacts of given changes of land use, i.e. the impact assessment component of the LCA, but very few have looked into how to actually do the inventory modelling, i.e. how to identify which land is ultimately affected by the decision and system under study. State...... in the systems being studied. The aims of this paper is to analyse the mechanisms influencing the long-term land use consequences of changes in crop demand and propose a methodological framework for identifying these consequences within a global scope. The outset of the paper is the principles of consequential...

Medical students' recognition and application of geriatrics principles in a new curriculum.

Science.gov (United States)

Nanda, Aman; Farrell, Timothy W; Shield, Renée R; Tomas, Maria; Campbell, Susan E; Wetle, Terrie

2013-03-01

Given the aging U.S. population, it is imperative that medical students recognize and apply geriatrics principles. To address this need, in 2006, the Warren Alpert Medical School of Brown University integrated geriatrics content into a new medical school curriculum. Preclinical and clinical medical students submitted written reflective journals in response to prompts regarding the geriatrics content of the new medical school curriculum, including their didactic and clinical experiences. An interdisciplinary team used a structured qualitative approach to identify themes, including the recognition and application of geriatrics principles. Thirty medical student journalers submitted 405 journal entries. Themes regarding students' emerging understanding of geriatrics principles included a growing understanding of geriatrics principles, recognition of the importance of psychosocial factors and patient preferences in caring for older adults, recognition of the complexities of treating older adults and application of geriatric principles to clinical situations, and understanding of physicians' roles in managing the care of older adults. Medical student reflective journaling allows medical educators to obtain timely feedback on curricular innovations and helps illuminate the process by which medical students learn to recognize and apply core geriatrics principles. © 2013, Copyright the Authors Journal compilation © 2013, The American Geriatrics Society.

Ethnography: principles, practice and potential.

Science.gov (United States)

Draper, Jan

2015-05-06

Ethnography is a methodology that is gaining popularity in nursing and healthcare research. It is concerned with studying people in their cultural context and how their behaviour, either as individuals or as part of a group, is influenced by this cultural context. Ethnography is a form of social research and has much in common with other forms of qualitative enquiry. While classical ethnography was characteristically concerned with describing 'other' cultures, contemporary ethnography has focused on settings nearer to home. This article outlines some of the underlying principles and practice of ethnography, and its potential for nursing and healthcare practice.

Radiation protection principles

International Nuclear Information System (INIS)

Ismail Bahari

2007-01-01

The presentation outlines the aspects of radiation protection principles. It discussed the following subjects; radiation hazards and risk, the objectives of radiation protection, three principles of the system - justification of practice, optimization of protection and safety, dose limit

The principle(s) of co-existence in Europe: Social, economic and legal avenues

NARCIS (Netherlands)

Purnhagen, K.; Wesseler, J.H.H.

2015-01-01

The European policy of coexistence follows a number of well-established social, economic and legal principles. Applying these principles in practice has resulted in a complex “rag rug” of coexistence policies in Europe. This rag rug makes enforcement of these principles difficult, at times even

The principle of optimisation: reasons for success and legal criticism

International Nuclear Information System (INIS)

Fernandez Regalado, Luis

2008-01-01

The International Commission on Radiological Protection (ICRP) has adopted new recommendations in 2007. In broad outlines they fundamentally continue the recommendations already approved in 1990 and later on. The principle of optimisation of protection, together with the principles of justification and dose limits, remains playing a key role of the ICRP recommendations, and it has so been for the last few years. This principle, somehow reinforced in the 2007 ICRP recommendations, has been incorporated into norms and legislation which have peacefully been in force in many countries all over the world. There are three main reasons to explain the success in the application of the principle of optimisation in radiological protection: First, the subjectivity of the sentence that embraces the principle of optimisation, 'As low as reasonably achievable' (ALARA), that allows different valid interpretations under different circumstances. Second, the pragmatism and adaptability of ALARA to all exposure situations. And third, the scientific humbleness which is behind the principle of optimisation, which makes a clear contrast with the old fashioned scientific positivism that enshrined scientist opinions. Nevertheless, from a legal point of view, there is some criticism cast over the principle of optimisation in radiological protection, where it has been transformed in compulsory norm. This criticism is based on two arguments: The lack of democratic participation in the process of elaboration of the norm, and the legal uncertainty associated to its application. Both arguments are somehow known by the ICRP which, on the one hand, has broadened the participation of experts, associations and the professional radiological protection community, increasing the transparency on how decisions on recommendations have been taken, and on the other hand, the ICRP has warned about the need for authorities to specify general criteria to develop the principle of optimisation in national

[Bioethics of principles].

Science.gov (United States)

Pérez-Soba Díez del Corral, Juan José

2008-01-01

Bioethics emerges about the tecnological problems of acting in human life. Emerges also the problem of the moral limits determination, because they seem exterior of this practice. The Bioethics of Principles, take his rationality of the teleological thinking, and the autonomism. These divergence manifest the epistemological fragility and the great difficulty of hmoralñ thinking. This is evident in the determination of autonomy's principle, it has not the ethical content of Kant's propose. We need a new ethic rationality with a new refelxion of new Principles whose emerges of the basic ethic experiences.

Principles of dynamics

CERN Document Server

Hill, Rodney

2013-01-01

Principles of Dynamics presents classical dynamics primarily as an exemplar of scientific theory and method. This book is divided into three major parts concerned with gravitational theory of planetary systems; general principles of the foundations of mechanics; and general motion of a rigid body. Some of the specific topics covered are Keplerian Laws of Planetary Motion; gravitational potential and potential energy; and fields of axisymmetric bodies. The principles of work and energy, fictitious body-forces, and inertial mass are also looked into. Other specific topics examined are kinematics

Emergency nurses' knowledge of pain management principles.

Science.gov (United States)

Tanabe, P; Buschmann, M

2000-08-01

The purpose of this study was to determine areas of emergency nurses' knowledge deficit regarding pain management, and to identify barriers to pain management as perceived by emergency nurses. Data were collected anonymously in a mail survey using a 52-item knowledge questionnaire addressing pain management principles and asking emergency nurses (Illinois Emergency Nurses Association members) to rate various barriers as to how often they affect their practice. Questionnaires were mailed to all Illinois ENA members (n = 1000). Three hundred five emergency nurses' questionnaires were returned. A significant deficit existed on 2 domains of knowledge: understanding of the terms "addiction," "tolerance," and "dependence"; and knowledge of various pharmacologic analgesic principles. Nurses with a master's degree or higher, or those who attended a 1-day seminar on pain management, achieved statistically significantly higher scores. The 2 barriers identified by emergency nurses as the most common were the inability to administer medication until a diagnosis is made (53%), and inadequate assessment of pain and pain relief (48%) (the percentage indicates how often the emergency nurses believed the barrier was present in their practice). The data indicate that emergency nurses may not have a good understanding of the management of pain with drugs, or of such issues as risk of addiction.

PRINCIPLES AND PROCEDURES ON FISCAL

Directory of Open Access Journals (Sweden)

Morar Ioan Dan

2011-07-01

Full Text Available Fiscal science advertise in most analytical situations, while the principles reiterated by specialists in the field in various specialized works The two components of taxation, the tax system relating to the theoretical and the practical procedures relating to tax are marked by frequent references and invocations of the underlying principles to tax. This paper attempts a return on equity fiscal general vision as a principle often invoked and used to justify tax policies, but so often violated the laws fiscality . Also want to emphasize the importance of devising procedures to ensure fiscal equitable treatment of taxpayers. Specific approach of this paper is based on the notion that tax equity is based on equality before tax and social policies of the executive that would be more effective than using the other tax instruments. I want to emphasize that if the scientific approach to justify the unequal treatment of the tax law is based on the various social problems of the taxpayers, then deviates from the issue of tax fairness justification explaining the need to promote social policies usually more attractive to taxpayers. Modern tax techniques are believed to be promoted especially in order to ensure an increasing level of high efficiency at the expense of the taxpayers obligations to ensure equality before the law tax. On the other hand, tax inequities reaction generates multiple recipients from the first budget plan, but finalities unfair measures can not quantify and no timeline for the reaction, usually not known. But while statistics show fluctuations in budgetary revenues and often find in literature reviews and analysis relevant to a connection between changes in government policies, budget execution and outcome. The effects of inequality on tax on tax procedures and budgetary revenues are difficult to quantify and is among others to this work. Providing tax equity without combining it with the principles of discrimination and neutrality

32 CFR 776.19 - Principles.

Science.gov (United States)

2010-07-01

... 32 National Defense 5 2010-07-01 2010-07-01 false Principles. 776.19 Section 776.19 National... Professional Conduct § 776.19 Principles. The Rules of this subpart are based on the following principles... exists, this subpart should be interpreted consistent with these general principles. (a) Covered...

Safety assessment principles for reactor protection systems in the United Kingdom

International Nuclear Information System (INIS)

Philp, W.

1990-01-01

The duty of Nuclear Installations Inspectorate (NII) is to see that the appropriate standards are developed, achieved and maintained by the plant operators, and to monitor and regulate the safety of the plant by means of its powers under the licence. It does not issue standards or codes of practice for NPPs, but it requires each plant operator to develop its own safety criteria and requirements. The following relevant issues are described: NII assessment principles and societal risks; principles and guidance for the assessment of rector protection systems; assessment of reactor shutdown systems

Safety assessment principles for reactor protection systems in the United Kingdom

Energy Technology Data Exchange (ETDEWEB)

Philp, W

1990-07-01

The duty of Nuclear Installations Inspectorate (NII) is to see that the appropriate standards are developed, achieved and maintained by the plant operators, and to monitor and regulate the safety of the plant by means of its powers under the licence. It does not issue standards or codes of practice for NPPs, but it requires each plant operator to develop its own safety criteria and requirements. The following relevant issues are described: NII assessment principles and societal risks; principles and guidance for the assessment of rector protection systems; assessment of reactor shutdown systems.

Extremum principles for irreversible processes

International Nuclear Information System (INIS)

Hillert, M.; Agren, J.

2006-01-01

Hamilton's extremum principle is a powerful mathematical tool in classical mechanics. Onsager's extremum principle may play a similar role in irreversible thermodynamics and may also become a valuable tool. His principle may formally be regarded as a principle of maximum rate of entropy production but does not have a clear physical interpretation. Prigogine's principle of minimum rate of entropy production has a physical interpretation when it applies, but is not strictly valid except for a very special case

The foundational principles as psychological lodestars: Theoretical inspiration and empirical direction in rehabilitation psychology.

Science.gov (United States)

Dunn, Dana S; Ehde, Dawn M; Wegener, Stephen T

2016-02-01

Historically, the Foundational Principles articulated by Wright (1983) and others guided theory development, research and scholarship, and practice in rehabilitation psychology. In recent decades, these principles have become more implicit and less explicit or expressive in the writings and work of rehabilitation professionals. We believe that the Foundational Principles are essential lodestars for working with people with disabilities that can guide inquiry, practice, and service. To introduce this special issues, this commentary identifies and defines key Foundational Principles, including, for example, Lewin's (1935) person-environment relation, adjustment to disability, the malleability of self-perceptions of bodily states, and the importance of promoting dignity for people with disabilities. We then consider the role the Foundational Principles play in the articles appearing in this special issue. We close by considering some new principles and their potential utility in rehabilitation settings. Readers in rehabilitation psychology and aligned areas (e.g., social-personality psychology, health psychology, rehabilitation therapist, psychiatry, and nursing) are encouraged to consider how the Foundational Principles underlie and can shape their research and practice. (c) 2016 APA, all rights reserved).

36 CFR 219.2 - Principles.

Science.gov (United States)

2010-07-01

... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Principles. 219.2 Section 219... Forest System Land and Resource Management Planning Purpose and Principles § 219.2 Principles. The planning regulations in this subpart are based on the following principles: (a) The first priority for...

Identify the Effective Wells in Determination of Groundwater Depth in Urmia Plain Using Principle Component Analysis

Directory of Open Access Journals (Sweden)

Sahar Babaei Hessar

2017-06-01

Full Text Available Introduction: Groundwater is the most important resource of providing sanitary water for potable and household consumption. So continuous monitoring of groundwater level will play an important role in water resource management. But because of the large amount of information, evaluation of water table is a costly and time consuming process. Therefore, in many studies, the data and information aren’t suitable and useful and so, must be neglected. The PCA technique is an optimized mathematical method that reserve data with the highest share in affirming variance with recognizing less important data and limits the original variables into to a few components. In this technique, variation factors called principle components are identified with considering data structures. Thus, variables those have the highest correlation coefficient with principal components are extracted as a result of identifying the components that create the greatest variance. Materials and Methods: The study region has an area of approximately 962 Km2 and area located between 37º 21´ N to 37º 49´ N and 44º 57´ E to 45º 16´ E in West Azerbaijan province of Iran. This area placed along the mountainous north-west of the country, which ends with the plane Urmia Lake and has vast groundwater resources. However, recently the water table has been reduced considerably because of the exceeded exploitation as a result of urbanization and increased agricultural and horticultural land uses. In the present study, the annual water table datasets in 51wells monitored by Ministry of Energy during statistical periods of 2002-2011 were used to data analysis. In order to identify the effective wells in determination of groundwater level, the PCA technique was used. In this research to compute the relative importance of each well, 10 wells were identified with the nearest neighbor for each one. The number of wells (p as a general rule must be less or equal to the maximum number of

Le Chatelier's Principle in Sensation and Perception: Fractal-Like Enfolding at Different Scales

Science.gov (United States)

Norwich, Kenneth H.

2010-01-01

Le Chatelier's principle asserts that a disturbance, when applied to a resting system may drive the system away from its equilibrium state, but will invoke a countervailing influence that will counteract the effect of the disturbance. When applied to the field of sensation and perception, a generalized stimulus will displace the system from equilibrium, and a generalized adaptation process will serve as the countervailing influence tending to reduce the impact of the stimulus. The principle applies at all levels, from the behavioral to the neural, the larger enfolding the smaller in fractal-like form. Le Chatelier's principle, so applied, leads to the unification of many concepts in sensory science. Ideas as diverse as sensory adaptation, reflex arcs, and simple deductive logic can be brought under the umbrella of a single orienting principle. Beyond unification, this principle allows us to approach many questions in pathophysiology from a different perspective. For example, we find new direction toward the reduction of phantom-limb pain and possibly of vertigo. PMID:21423359

Principles of taxation as a means of implementing fiscal function of the tax

Directory of Open Access Journals (Sweden)

К. О. Гетьман

2015-05-01

of the mechanisms of their creation and operation; determine whether the taxation principles for the reform of the tax system of Ukraine; forecasting the development of the industry in the areas of finance, which determine its integrity, consistency, effectiveness, stability, interconnectedness its legal institutions. The object of study is social relations that emerge and operate under the influence of legal regulation of taxation principles, as a means of implementing fiscal function of tax. Purpose of the study constitutes legal norms that reinforce the principles of taxation and provide their detailed formation mechanism of implementation through the special tax instruments (taxes, duties and other compulsory payments. Paper main body. description of  the features of the tax should be based on the effect of the significant leverage in tax regulation. Still another sustained a lively discussion about the number and nature of these functions. According to the author, the most balanced view of the tax system functions can provide three of them: adjusting, fiscal and  control. Last one, in the opinion of the author  expresses the main purpose of the tax - the formation of public funds needs funding for state and local communities.It is clear that the function of the tax system affecting the corresponding homogeneous kind of public relations should provide for a holistic effect on the ordering process receipts from taxes and duties (mandatory payments. As a particular manifestation of the sense of these features can be found at every level of the tax regulation. It is, as on general regulations affecting the behavior of tax administration and then refined and detailed rules all tax laws and regulations more narrow focus concerning certain specific elements of the tax or fee.Legislative detailing how all functions of taxes, and each of them separately, systematically done by defining principles - in the current Tax Code of Ukraine, this century 4 «Basic principles

A conceptual framework of game-informed principles for health professions education.

Science.gov (United States)

Ellaway, Rachel H

2016-01-01

Games have been used for training purposes for many years, but their use remains somewhat underdeveloped and under-theorized in health professional education. This paper considers the basis for using serious games (games that have an explicit educational purpose) in health professional education in terms of their underlying concepts and design principles. These principles can be understood as a series of game facets: competition and conflict, chance and luck, experience and performance, simulation and make-believe, tactics and strategies, media, symbols and actions, and complexity and difficulty. Games are distinct and bound in ways that other health professional education activities are not. The differences between games and simulation can be understood in terms of the interconnected concepts of isomorphism (convergence with real-world practice) and anisomorphism (divergence from real-world practice). Gaming facets can extend the instructional design repertoire in health professional education.

Theoretical preconditions of the realization of principle of domination of essence over form

Directory of Open Access Journals (Sweden)

T.S. Osadcha

2015-06-01

Full Text Available Organization and accounting should be based on accounting principles, which must ensure qualitative preparation of the financial statements. In this case an important role is played by the principle of domination of essence over form. Here is analyzed the main factors of its development and dissemination. Also it is determined the role of IFRS in the spreading of the principle of domination of essence over form in the world and its fixation on the level of normative regulation of accounting in certain countries, including Ukraine. It is defined theoretical preconditions for identifying and removing the existing obstacles in the application of the principle of domination of essence over form in the practice of management, which will ensure qualitative preparation of the financial statements. It is offered to use the principle of property rights theory, the theory of rent and the agency theory to solve the problem of disseverance between owner and manager.

Diffusion in thorium carbide: A first-principles study

Energy Technology Data Exchange (ETDEWEB)

Pérez Daroca, D., E-mail: pdaroca@tandar.cnea.gov.ar [Gerencia de Investigación y Aplicaciones, Comisión Nacional de Energía Atómica, Av. General Paz 1499, 1650, San Martín, Buenos Aires (Argentina); Consejo Nacional de Investigaciones Científicas y Técnicas, 1025, Buenos Aires (Argentina); Llois, A.M. [Gerencia de Investigación y Aplicaciones, Comisión Nacional de Energía Atómica, Av. General Paz 1499, 1650, San Martín, Buenos Aires (Argentina); Consejo Nacional de Investigaciones Científicas y Técnicas, 1025, Buenos Aires (Argentina); Mosca, H.O. [Gerencia de Investigación y Aplicaciones, Comisión Nacional de Energía Atómica, Av. General Paz 1499, 1650, San Martín, Buenos Aires (Argentina); Instituto de Tecnología Jorge A. Sabato, UNSAM–CNEA, Av. General Paz 1499, 1650, San Martín, Buenos Aires (Argentina)

2015-12-15

The prediction of the behavior of Th compounds under irradiation is an important issue for the upcoming Generation-IV nuclear reactors. The study of self-diffusion and hetero-diffusion is a central key to fulfill this goal. As a first approach, we obtained, by means of first-principles methods, migration and activation energies of Th and C atoms self-diffusion and diffusion of He atoms in ThC. We also calculate diffusion coefficients as a function of temperature. - Highlights: • Diffusion in thorium carbide by means of first-principles calculations is studied. • The most favorable migration event is a C atom moving through a C-vacancy aided path. • Calculated C atoms diffusion coefficients agree very well with the experimental data. • For He, the energetically most favorable migration path is through Th-vacancies.

Stakeholders' Perspectives on Stakeholder-engaged Research (SER): Strategies to Operationalize Patient-centered Outcomes Research Principles for SER.

Science.gov (United States)

Mackie, Thomas I; Sheldrick, Radley C; de Ferranti, Sarah D; Saunders, Tully; Rojas, Erick G; Leslie, Laurel K

2017-01-01

US federal funding agencies increasingly incentivize stakeholder-engaged research which represents a paradigm shift toward incorporating a range of stakeholders in research design, conduct, and dissemination. We use qualitative methods to capture experience-based recommendations on how to operationalize 4 Patient-Centered Outcomes Research (PCOR) principles in stakeholder-engaged research, specifically: (1) reciprocal relationships; (2) colearning; (3) partnership; and (4) trust, transparency, and honesty. We conducted semistructured interviews with members of a stakeholder panel who participated in a 2-year comparative effectiveness study of cholesterol screening and treatment among young adults. Participants included 8 young adults and parent panelists and 11 professional panelists (clinicians, researchers, policy developers, and disseminators). The interview guide included questions about the 4 PCOR principles and queried preferred strategies to attain them. Interview transcripts were analyzed using an a priori and emergent coding structure. Participants provided strategies to promote the 4 PCOR principles. Although some stakeholder-identified strategies were complementary, others conflicted due to (1) competing ideologies identified among the principles, and (2) distinct stakeholder preferences. Illustrative of competing ideologies, participants simultaneously preferred receiving relevant articles before calls (to facilitate colearning) but also minimal outside reading (to achieve partnership). Illustrative of distinct stakeholder preferences, young adult and parent panelists generally preferred calls to occur on weekends/evenings, whereas professional panelists preferred mid-week work hours. Our exploratory study provides stakeholder-identified strategies to achieve the 4 PCOR principles, and demonstrates the need to identify, acknowledge, and address potentially conflicting strategies due to the potential for competing ideologies or variation in stakeholder

Novel genetic loci underlying human intracranial volume identified through genome-wide association

Science.gov (United States)

Adams, Hieab HH; Hibar, Derrek P; Chouraki, Vincent; Stein, Jason L; Nyquist, Paul A; Rentería, Miguel E; Trompet, Stella; Arias-Vasquez, Alejandro; Seshadri, Sudha; Desrivières, Sylvane; Beecham, Ashley H; Jahanshad, Neda; Wittfeld, Katharina; Van der Lee, Sven J; Abramovic, Lucija; Alhusaini, Saud; Amin, Najaf; Andersson, Micael; Arfanakis, Konstantinos; Aribisala, Benjamin S; Armstrong, Nicola J; Athanasiu, Lavinia; Axelsson, Tomas; Beiser, Alexa; Bernard, Manon; Bis, Joshua C; Blanken, Laura ME; Blanton, Susan H; Bohlken, Marc M; Boks, Marco P; Bralten, Janita; Brickman, Adam M; Carmichael, Owen; Chakravarty, M Mallar; Chauhan, Ganesh; Chen, Qiang; Ching, Christopher RK; Cuellar-Partida, Gabriel; Den Braber, Anouk; Doan, Nhat Trung; Ehrlich, Stefan; Filippi, Irina; Ge, Tian; Giddaluru, Sudheer; Goldman, Aaron L; Gottesman, Rebecca F; Greven, Corina U; Grimm, Oliver; Griswold, Michael E; Guadalupe, Tulio; Hass, Johanna; Haukvik, Unn K; Hilal, Saima; Hofer, Edith; Hoehn, David; Holmes, Avram J; Hoogman, Martine; Janowitz, Deborah; Jia, Tianye; Kasperaviciute, Dalia; Kim, Sungeun; Klein, Marieke; Kraemer, Bernd; Lee, Phil H; Liao, Jiemin; Liewald, David CM; Lopez, Lorna M; Luciano, Michelle; Macare, Christine; Marquand, Andre; Matarin, Mar; Mather, Karen A; Mattheisen, Manuel; Mazoyer, Bernard; McKay, David R; McWhirter, Rebekah; Milaneschi, Yuri; Mirza-Schreiber, Nazanin; Muetzel, Ryan L; Maniega, Susana Muñoz; Nho, Kwangsik; Nugent, Allison C; Olde Loohuis, Loes M; Oosterlaan, Jaap; Papmeyer, Martina; Pappa, Irene; Pirpamer, Lukas; Pudas, Sara; Pütz, Benno; Rajan, Kumar B; Ramasamy, Adaikalavan; Richards, Jennifer S; Risacher, Shannon L; Roiz-Santiañez, Roberto; Rommelse, Nanda; Rose, Emma J; Royle, Natalie A; Rundek, Tatjana; Sämann, Philipp G; Satizabal, Claudia L; Schmaal, Lianne; Schork, Andrew J; Shen, Li; Shin, Jean; Shumskaya, Elena; Smith, Albert V; Sprooten, Emma; Strike, Lachlan T; Teumer, Alexander; Thomson, Russell; Tordesillas-Gutierrez, Diana; Toro, Roberto; Trabzuni, Daniah; Vaidya, Dhananjay; Van der Grond, Jeroen; Van der Meer, Dennis; Van Donkelaar, Marjolein MJ; Van Eijk, Kristel R; Van Erp, Theo GM; Van Rooij, Daan; Walton, Esther; Westlye, Lars T; Whelan, Christopher D; Windham, Beverly G; Winkler, Anderson M; Woldehawariat, Girma; Wolf, Christiane; Wolfers, Thomas; Xu, Bing; Yanek, Lisa R; Yang, Jingyun; Zijdenbos, Alex; Zwiers, Marcel P; Agartz, Ingrid; Aggarwal, Neelum T; Almasy, Laura; Ames, David; Amouyel, Philippe; Andreassen, Ole A; Arepalli, Sampath; Assareh, Amelia A; Barral, Sandra; Bastin, Mark E; Becker, Diane M; Becker, James T; Bennett, David A; Blangero, John; van Bokhoven, Hans; Boomsma, Dorret I; Brodaty, Henry; Brouwer, Rachel M; Brunner, Han G; Buckner, Randy L; Buitelaar, Jan K; Bulayeva, Kazima B; Cahn, Wiepke; Calhoun, Vince D; Cannon, Dara M; Cavalleri, Gianpiero L; Chen, Christopher; Cheng, Ching-Yu; Cichon, Sven; Cookson, Mark R; Corvin, Aiden; Crespo-Facorro, Benedicto; Curran, Joanne E; Czisch, Michael; Dale, Anders M; Davies, Gareth E; De Geus, Eco JC; De Jager, Philip L; de Zubicaray, Greig I; Delanty, Norman; Depondt, Chantal; DeStefano, Anita L; Dillman, Allissa; Djurovic, Srdjan; Donohoe, Gary; Drevets, Wayne C; Duggirala, Ravi; Dyer, Thomas D; Erk, Susanne; Espeseth, Thomas; Evans, Denis A; Fedko, Iryna O; Fernández, Guillén; Ferrucci, Luigi; Fisher, Simon E; Fleischman, Debra A; Ford, Ian; Foroud, Tatiana M; Fox, Peter T; Francks, Clyde; Fukunaga, Masaki; Gibbs, J Raphael; Glahn, David C; Gollub, Randy L; Göring, Harald HH; Grabe, Hans J; Green, Robert C; Gruber, Oliver; Gudnason, Vilmundur; Guelfi, Sebastian; Hansell, Narelle K; Hardy, John; Hartman, Catharina A; Hashimoto, Ryota; Hegenscheid, Katrin; Heinz, Andreas; Le Hellard, Stephanie; Hernandez, Dena G; Heslenfeld, Dirk J; Ho, Beng-Choon; Hoekstra, Pieter J; Hoffmann, Wolfgang; Hofman, Albert; Holsboer, Florian; Homuth, Georg; Hosten, Norbert; Hottenga, Jouke-Jan; Hulshoff Pol, Hilleke E; Ikeda, Masashi; Ikram, M Kamran; Jack, Clifford R; Jenkinson, Mark; Johnson, Robert; Jönsson, Erik G; Jukema, J Wouter; Kahn, René S; Kanai, Ryota; Kloszewska, Iwona; Knopman, David S; Kochunov, Peter; Kwok, John B; Lawrie, Stephen M; Lemaître, Hervé; Liu, Xinmin; Longo, Dan L; Longstreth, WT; Lopez, Oscar L; Lovestone, Simon; Martinez, Oliver; Martinot, Jean-Luc; Mattay, Venkata S; McDonald, Colm; McIntosh, Andrew M; McMahon, Katie L; McMahon, Francis J; Mecocci, Patrizia; Melle, Ingrid; Meyer-Lindenberg, Andreas; Mohnke, Sebastian; Montgomery, Grant W; Morris, Derek W; Mosley, Thomas H; Mühleisen, Thomas W; Müller-Myhsok, Bertram; Nalls, Michael A; Nauck, Matthias; Nichols, Thomas E; Niessen, Wiro J; Nöthen, Markus M; Nyberg, Lars; Ohi, Kazutaka; Olvera, Rene L; Ophoff, Roel A; Pandolfo, Massimo; Paus, Tomas; Pausova, Zdenka; Penninx, Brenda WJH; Pike, G Bruce; Potkin, Steven G; Psaty, Bruce M; Reppermund, Simone; Rietschel, Marcella; Roffman, Joshua L; Romanczuk-Seiferth, Nina; Rotter, Jerome I; Ryten, Mina; Sacco, Ralph L; Sachdev, Perminder S; Saykin, Andrew J; Schmidt, Reinhold; Schofield, Peter R; Sigurdsson, Sigurdur; Simmons, Andy; Singleton, Andrew; Sisodiya, Sanjay M; Smith, Colin; Smoller, Jordan W; Soininen, Hilkka; Srikanth, Velandai; Steen, Vidar M; Stott, David J; Sussmann, Jessika E; Thalamuthu, Anbupalam; Tiemeier, Henning; Toga, Arthur W; Traynor, Bryan J; Troncoso, Juan; Turner, Jessica A; Tzourio, Christophe; Uitterlinden, Andre G; Valdés Hernández, Maria C; Van der Brug, Marcel; Van der Lugt, Aad; Van der Wee, Nic JA; Van Duijn, Cornelia M; Van Haren, Neeltje EM; Van 't Ent, Dennis; Van Tol, Marie-Jose; Vardarajan, Badri N; Veltman, Dick J; Vernooij, Meike W; Völzke, Henry; Walter, Henrik; Wardlaw, Joanna M; Wassink, Thomas H; Weale, Michael E; Weinberger, Daniel R; Weiner, Michael W; Wen, Wei; Westman, Eric; White, Tonya; Wong, Tien Y; Wright, Clinton B; Zielke, H Ronald; Zonderman, Alan B; Deary, Ian J; DeCarli, Charles; Schmidt, Helena; Martin, Nicholas G; De Craen, Anton JM; Wright, Margaret J; Launer, Lenore J; Schumann, Gunter; Fornage, Myriam; Franke, Barbara; Debette, Stéphanie; Medland, Sarah E; Ikram, M Arfan; Thompson, Paul M

2016-01-01

Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438 adults, we discovered five novel loci for intracranial volume and confirmed two known signals. Four of the loci are also associated with adult human stature, but these remained associated with intracranial volume after adjusting for height. We found a high genetic correlation with child head circumference (ρgenetic=0.748), which indicated a similar genetic background and allowed for the identification of four additional loci through meta-analysis (Ncombined = 37,345). Variants for intracranial volume were also related to childhood and adult cognitive function, Parkinson’s disease, and enriched near genes involved in growth pathways including PI3K–AKT signaling. These findings identify biological underpinnings of intracranial volume and provide genetic support for theories on brain reserve and brain overgrowth. PMID:27694991

The balance principle in scientific research.

Science.gov (United States)

Hu, Liang-ping; Bao, Xiao-lei; Wang, Qi

2012-05-01

The principles of balance, randomization, control and repetition, which are closely related, constitute the four principles of scientific research. The balance principle is the kernel of the four principles which runs through the other three. However, in scientific research, the balance principle is always overlooked. If the balance principle is not well performed, the research conclusion is easy to be denied, which may lead to the failure of the whole research. Therefore, it is essential to have a good command of the balance principle in scientific research. This article stresses the definition and function of the balance principle, the strategies and detailed measures to improve balance in scientific research, and the analysis of the common mistakes involving the use of the balance principle in scientific research.

The Generalized Principle of the Golden Section and its applications in mathematics, science, and engineering

International Nuclear Information System (INIS)

Stakhov, A.P.

2005-01-01

The 'Dichotomy Principle' and the classical 'Golden Section Principle' are two of the most important principles of Nature, Science and also Art. The Generalized Principle of the Golden Section that follows from studying the diagonal sums of the Pascal triangle is a sweeping generalization of these important principles. This underlies the foundation of 'Harmony Mathematics', a new proposed mathematical direction. Harmony Mathematics includes a number of new mathematical theories: an algorithmic measurement theory, a new number theory, a new theory of hyperbolic functions based on Fibonacci and Lucas numbers, and a theory of the Fibonacci and 'Golden' matrices. These mathematical theories are the source of many new ideas in mathematics, philosophy, botanic and biology, electrical and computer science and engineering, communication systems, mathematical education as well as theoretical physics and physics of high energy particles

A survey of variational principles

International Nuclear Information System (INIS)

Lewins, J.D.

1993-01-01

The survey of variational principles has ranged widely from its starting point in the Lagrange multiplier to optimisation principles. In an age of digital computation, these classic methods can be adapted to improve such calculations. We emphasize particularly the advantage of basing finite element methods on variational principles, especially if, as maximum and minimum principles, these can provide bounds and hence estimates of accuracy. The non-symmetric (and hence stationary rather than extremum principles) are seen however to play a significant role in optimisation theory. (Orig./A.B.)

Distributed Consensus of Stochastic Delayed Multi-agent Systems Under Asynchronous Switching.

Science.gov (United States)

Wu, Xiaotai; Tang, Yang; Cao, Jinde; Zhang, Wenbing

2016-08-01

In this paper, the distributed exponential consensus of stochastic delayed multi-agent systems with nonlinear dynamics is investigated under asynchronous switching. The asynchronous switching considered here is to account for the time of identifying the active modes of multi-agent systems. After receipt of confirmation of mode's switching, the matched controller can be applied, which means that the switching time of the matched controller in each node usually lags behind that of system switching. In order to handle the coexistence of switched signals and stochastic disturbances, a comparison principle of stochastic switched delayed systems is first proved. By means of this extended comparison principle, several easy to verified conditions for the existence of an asynchronously switched distributed controller are derived such that stochastic delayed multi-agent systems with asynchronous switching and nonlinear dynamics can achieve global exponential consensus. Two examples are given to illustrate the effectiveness of the proposed method.

Obtaining the electrostatic screening from first principles

International Nuclear Information System (INIS)

Shaviv, N.J.; Shaviv, G.

2003-01-01

We derive the electrostatic screening effect from first principles and show the basic properties of the screening process. We in particular show that under the conditions prevailing in the Sun the number of particles in the Debye sphere is of the order of unity. Consequently; fluctuations play a dominant role in the screening process. The fluctuations lead to an effective time dependent potential. Particles with low kinetic energy lose on the average energy to the plasma and vice versa with high energy particles. We derive general conditions on the screening energy and show under what conditions the Salpeter approximation is obtained. The connection between the screening and relaxation processes in the plasma is exposed

Exposing the “One China” Principle

Directory of Open Access Journals (Sweden)

Chien-yuan Tseng

2016-12-01

Full Text Available In 1992, when the governments from both sides across the Taiwan Strait began having contacts, both of them, at the People’s Republic of China (PRC’s request, expressed verbally, and in relation to functional issues, that they advocated the “one China” principle, though what “one China” actually meant was open to different interpretations, and the shift that elevated the 1992 “one China” interpretations from the functional level to the political level did not occur until April 2005. Since President Tsai Ing-wen was sworn in and the Democratic Progressive Party (DPP became the ruling party of the Republic of China (ROC on Taiwan in early 2016, the PRC has used Tsai’s rejection of this so-called “1992 consensus” as a pretext to discontinue all intergovernmental communication channels with the ROC on Taiwan, while also cutting down on cross-strait civil exchanges in travel and education. This thinkpiece article aims to scrutinise this “one China” principle, how it has developed over the years, and expose its underlying realities.

How powerful are summary-based methods for identifying expression-trait associations under different genetic architectures?

Science.gov (United States)

Veturi, Yogasudha; Ritchie, Marylyn D

2018-01-01

Transcriptome-wide association studies (TWAS) have recently been employed as an approach that can draw upon the advantages of genome-wide association studies (GWAS) and gene expression studies to identify genes associated with complex traits. Unlike standard GWAS, summary level data suffices for TWAS and offers improved statistical power. Two popular TWAS methods include either (a) imputing the cis genetic component of gene expression from smaller sized studies (using multi-SNP prediction or MP) into much larger effective sample sizes afforded by GWAS - TWAS-MP or (b) using summary-based Mendelian randomization - TWAS-SMR. Although these methods have been effective at detecting functional variants, it remains unclear how extensive variability in the genetic architecture of complex traits and diseases impacts TWAS results. Our goal was to investigate the different scenarios under which these methods yielded enough power to detect significant expression-trait associations. In this study, we conducted extensive simulations based on 6000 randomly chosen, unrelated Caucasian males from Geisinger's MyCode population to compare the power to detect cis expression-trait associations (within 500 kb of a gene) using the above-described approaches. To test TWAS across varying genetic backgrounds we simulated gene expression and phenotype using different quantitative trait loci per gene and cis-expression /trait heritability under genetic models that differentiate the effect of causality from that of pleiotropy. For each gene, on a training set ranging from 100 to 1000 individuals, we either (a) estimated regression coefficients with gene expression as the response using five different methods: LASSO, elastic net, Bayesian LASSO, Bayesian spike-slab, and Bayesian ridge regression or (b) performed eQTL analysis. We then sampled with replacement 50,000, 150,000, and 300,000 individuals respectively from the testing set of the remaining 5000 individuals and conducted GWAS on each

Identifying the rooted species tree from the distribution of unrooted gene trees under the coalescent.

Science.gov (United States)

Allman, Elizabeth S; Degnan, James H; Rhodes, John A

2011-06-01

Gene trees are evolutionary trees representing the ancestry of genes sampled from multiple populations. Species trees represent populations of individuals-each with many genes-splitting into new populations or species. The coalescent process, which models ancestry of gene copies within populations, is often used to model the probability distribution of gene trees given a fixed species tree. This multispecies coalescent model provides a framework for phylogeneticists to infer species trees from gene trees using maximum likelihood or Bayesian approaches. Because the coalescent models a branching process over time, all trees are typically assumed to be rooted in this setting. Often, however, gene trees inferred by traditional phylogenetic methods are unrooted. We investigate probabilities of unrooted gene trees under the multispecies coalescent model. We show that when there are four species with one gene sampled per species, the distribution of unrooted gene tree topologies identifies the unrooted species tree topology and some, but not all, information in the species tree edges (branch lengths). The location of the root on the species tree is not identifiable in this situation. However, for 5 or more species with one gene sampled per species, we show that the distribution of unrooted gene tree topologies identifies the rooted species tree topology and all its internal branch lengths. The length of any pendant branch leading to a leaf of the species tree is also identifiable for any species from which more than one gene is sampled.

Scattered Radiation Emission Imaging: Principles and Applications

Directory of Open Access Journals (Sweden)

M. K. Nguyen

2011-01-01

Full Text Available Imaging processes built on the Compton scattering effect have been under continuing investigation since it was first suggested in the 50s. However, despite many innovative contributions, there are still formidable theoretical and technical challenges to overcome. In this paper, we review the state-of-the-art principles of the so-called scattered radiation emission imaging. Basically, it consists of using the cleverly collected scattered radiation from a radiating object to reconstruct its inner structure. Image formation is based on the mathematical concept of compounded conical projection. It entails a Radon transform defined on circular cone surfaces in order to express the scattered radiation flux density on a detecting pixel. We discuss in particular invertible cases of such conical Radon transforms which form a mathematical basis for image reconstruction methods. Numerical simulations performed in two and three space dimensions speak in favor of the viability of this imaging principle and its potential applications in various fields.

Two Eyes, 3D: Stereoscopic Design Principles

Science.gov (United States)

Price, Aaron; Subbarao, M.; Wyatt, R.

2013-01-01

Two Eyes, 3D is a NSF-funded research project about how people perceive highly spatial objects when shown with 2D or stereoscopic ("3D") representations. As part of the project, we produced a short film about SN 2011fe. The high definition film has been rendered in both 2D and stereoscopic formats. It was developed according to a set of stereoscopic design principles we derived from the literature and past experience producing and studying stereoscopic films. Study participants take a pre- and post-test that involves a spatial cognition assessment and scientific knowledge questions about Type-1a supernovae. For the evaluation, participants use iPads in order to record spatial manipulation of the device and look for elements of embodied cognition. We will present early results and also describe the stereoscopic design principles and the rationale behind them. All of our content and software is available under open source licenses. More information is at www.twoeyes3d.org.

Magnetic resonance imaging principles: The bare necessities

International Nuclear Information System (INIS)

Brant-Zawadzki, M.

1987-01-01

The intent of this chapter is to provide the practicing radiologist with a conceptual basis for the underlying principles of magnetic resonance imaging (MRI). The goal of what follows is to provide the reader with a conceptual framework in a relatively facile manner. By design, some repetition and certain oversimplifications will be used, and the experts might argue that accuracy is stretched by this approach. It should be pointed out, however, that even the experts still debate some of the most fundamental aspects of MRI, and that the rapid evolution of knowledge regarding MRI principles, instrumentation, and imaging techniques makes even their most ambitious treatment obsolete by the time it is printed. Nevertheless, the rapid dissemination of this technology in the clinical arena necessitates that most radiologists, need at least a conceptual model of the fundamentals with which to approach MRI, and need eventually to enrich their understanding through hands-on experience and further study. Providing a working conceptual model is the limited goal of this chapter

The action principle for a system of differential equations

International Nuclear Information System (INIS)

Gitman, D M; Kupriyanov, V G

2007-01-01

We consider the problem of constructing an action functional for physical systems whose classical equations of motion cannot be directly identified with Euler-Lagrange equations for an action principle. Two ways of constructing the action principle are presented. From simple consideration, we derive the necessary and sufficient conditions for the existence of a multiplier matrix which can endow a prescribed set of second-order differential equations with the structure of the Euler-Lagrange equations. An explicit form of the action is constructed if such a multiplier exists. If a given set of differential equations cannot be derived from an action principle, one can reformulate such a set in an equivalent first-order form which can always be treated as the Euler-Lagrange equations of a certain action. We construct such an action explicitly. There exists an ambiguity (not reduced to a total time derivative) in associating a Lagrange function with a given set of equations. We present a complete description of this ambiguity. The general procedure is illustrated by several examples

The action principle for a system of differential equations

Energy Technology Data Exchange (ETDEWEB)

Gitman, D M [Instituto de FIsica, Universidade de Sao Paulo (Brazil); Kupriyanov, V G [Instituto de FIsica, Universidade de Sao Paulo (Brazil)

2007-08-17

We consider the problem of constructing an action functional for physical systems whose classical equations of motion cannot be directly identified with Euler-Lagrange equations for an action principle. Two ways of constructing the action principle are presented. From simple consideration, we derive the necessary and sufficient conditions for the existence of a multiplier matrix which can endow a prescribed set of second-order differential equations with the structure of the Euler-Lagrange equations. An explicit form of the action is constructed if such a multiplier exists. If a given set of differential equations cannot be derived from an action principle, one can reformulate such a set in an equivalent first-order form which can always be treated as the Euler-Lagrange equations of a certain action. We construct such an action explicitly. There exists an ambiguity (not reduced to a total time derivative) in associating a Lagrange function with a given set of equations. We present a complete description of this ambiguity. The general procedure is illustrated by several examples.

Unambiguously identifying spin states of transition-metal ions in the Earth (Invited)

Science.gov (United States)

Hsu, H.

2010-12-01

The spin state of a transition-metal ion in crystalline solids, defined by the number of unpaired electrons in the ion’s incomplete 3d shell, may vary with many factors, such as temperature, pressure, strain, and the local atomic configuration, to name a few. Such a phenomenon, known as spin-state crossover, plays a crucial role in spintronic materials. Recently, the pressure-induced spin-state crossover in iron-bearing minerals has been recognized to affect the minerals’ structural and elastic properties. However, the detailed mechanism of such crossover in iron-bearing magnesium silicate perovskite, the most abundant mineral in the Earth, remains unclear. A significant part of this confusion arises from the difficulty in reliably extracting the spin state from experiments. For the same reason, the thermally-induced spin-state crossover in lanthanum cobaltite (LaCoO3) has been controversial for more than four decades. In this talk, I will discuss how first-principle calculations can help clarifying these long-standing controversies. In addition to the total energy, equation of state, and elastic properties of each spin state, first-principle calculations also predict the electric field gradient (EFG) at the nucleus of each transition-metal ion. Our calculations showed that the nuclear EFG, a quantity that can be measured via Mössbauer or nuclear magnetic resonance (NMR) spectroscopy, depends primarily on the spin state, irrespective of the concentration or configuration of transition-metal ions. Such robustness makes EFG a unique fingerprint to identify the spin state. The combination of first-principle calculations and Mössbauer/NMR spectroscopy can therefore be a reliable and efficient approach in tackling spin-state crossover problems in the Earth. This work was primarily supported by the MRSEC Program of NSF under Awards Number DMR-0212302 and DMR-0819885, and partially supported by NSF under ATM-0428774 (V-Lab), EAR-1019853, and EAR-0810272. The

The Generalized Principle of the Golden Section and its applications in mathematics, science, and engineering

Energy Technology Data Exchange (ETDEWEB)

Stakhov, A.P. [International Club of the Golden Section, 6 McCreary Trail, Bolton, ON, L7E 2C8 (Canada)] e-mail: goldenmuseum@rogers.com

2005-10-01

The 'Dichotomy Principle' and the classical 'Golden Section Principle' are two of the most important principles of Nature, Science and also Art. The Generalized Principle of the Golden Section that follows from studying the diagonal sums of the Pascal triangle is a sweeping generalization of these important principles. This underlies the foundation of 'Harmony Mathematics', a new proposed mathematical direction. Harmony Mathematics includes a number of new mathematical theories: an algorithmic measurement theory, a new number theory, a new theory of hyperbolic functions based on Fibonacci and Lucas numbers, and a theory of the Fibonacci and 'Golden' matrices. These mathematical theories are the source of many new ideas in mathematics, philosophy, botanic and biology, electrical and computer science and engineering, communication systems, mathematical education as well as theoretical physics and physics of high energy particles.

Methodological principles outline discipline "Organization studies-tourism activity" using information technologies.

Directory of Open Access Journals (Sweden)

Kozina Zh.L.

2011-08-01

Full Text Available The basic methodological principles of the disciplines of tourism and local history with information technology. 15 analyzed the literature and experience of leading experts in the field of sports and health tourism, and orienteering. Identified principles of academic disciplines of tourism and local history: the shift in emphasis from sports tourism to the cognitive, health tourism, the development of spiritual qualities, acquisition of life skills in nature, discovery and development of pedagogical and psychological abilities, character traits through the study of native land, the development of cognitive-research abilities, physical abilities, motor skills, application of modern information technology.

Applying lean principles to continuous renal replacement therapy processes.

Science.gov (United States)

Benfield, C Brett; Brummond, Philip; Lucarotti, Andrew; Villarreal, Maria; Goodwin, Adam; Wonnacott, Rob; Talley, Cheryl; Heung, Michael

2015-02-01

The application of lean principles to continuous renal replacement therapy (CRRT) processes in an academic medical center is described. A manual audit over six consecutive weeks revealed that 133 5-L bags of CRRT solution were discarded after being dispensed from pharmacy but before clinical use. Lean principles were used to examine the workflow for CRRT preparation and develop and implement an intervention. An educational program was developed to encourage and enhance direct communication between nursing and pharmacy about changes in a patient's condition or CRRT order. It was through this education program that the reordering workflow shifted from nurses to pharmacy technicians. The primary outcome was the number of CRRT solution bags delivered in the preintervention and postintervention periods. Nurses and pharmacy technicians were surveyed to determine their satisfaction with the workflow change. After implementation of lean principles, the mean number of CRRT solution bags dispensed per day of CRRT decreased substantially. Respondents' overall satisfaction with the CRRT solution preparation process increased during the postintervention period, and the satisfaction scores for each individual component of the workflow after implementation of lean principles. The decreased solution waste resulted in projected annual cost savings exceeding $70,000 in product alone. The use of lean principles to identify medication waste in the CRRT workflow and implementation of an intervention to shift the workload from intensive care unit nurses to pharmacy technicians led to reduced CRRT solution waste, improved efficiency of CRRT workflow, and increased satisfaction among staff. Copyright © 2015 by the American Society of Health-System Pharmacists, Inc. All rights reserved.

Introductory remote sensing principles and concepts principles and concepts

CERN Document Server

Gibson, Paul

2013-01-01

Introduction to Remote Sensing Principles and Concepts provides a comprehensive student introduction to both the theory and application of remote sensing. This textbook* introduces the field of remote sensing and traces its historical development and evolution* presents detailed explanations of core remote sensing principles and concepts providing the theory required for a clear understanding of remotely sensed images.* describes important remote sensing platforms - including Landsat, SPOT and NOAA * examines and illustrates many of the applications of remotely sensed images in various fields.

Earth Science Principles Pertinent to the General Education Programs in Junior High Schools

Science.gov (United States)

Henson, Kenneth Tyrone

1970-01-01

Presents the procedures, and findings of a study designed to identify principles in astronomy, geology, meterology, oceanography and physical geography pertinent to general education programs in junior high schools. (LC)

A survey of variational principles

International Nuclear Information System (INIS)

Lewins, J.D.

1993-01-01

In this article survey of variational principles has been given. Variational principles play a significant role in mathematical theory with emphasis on the physical aspects. There are two principals used i.e. to represent the equation of the system in a succinct way and to enable a particular computation in the system to be carried out with greater accuracy. The survey of variational principles has ranged widely from its starting point in the Lagrange multiplier to optimisation principles. In an age of digital computation, these classic methods can be adapted to improve such calculations. We emphasize particularly the advantage of basic finite element methods on variational principles. (A.B.)

Mach's principle and rotating universes

International Nuclear Information System (INIS)

King, D.H.

1990-01-01

It is shown that the Bianchi 9 model universe satisfies the Mach principle. These closed rotating universes were previously thought to be counter-examples to the principle. The Mach principle is satisfied because the angular momentum of the rotating matter is compensated by the effective angular momentum of gravitational waves. A new formulation of the Mach principle is given that is based on the field theory interpretation of general relativity. Every closed universe with 3-sphere topology is shown to satisfy this formulation of the Mach principle. It is shown that the total angular momentum of the matter and gravitational waves in a closed 3-sphere topology universe is zero

Occupational Pension Funds (IORPs) & Sustainability: What does the Prudent Person Principle say?

DEFF Research Database (Denmark)

Horváthová, Alexandra; Feldthusen, Rasmus Kristian; Ulfbeck, Vibe Garf

2017-01-01

The European Union encourages individuals to save in private and occupational pension funds to complement their state saving-plans. Throughout their lives, employers directly sponsor occupational retirement saving plans, so individual employees may top up their future pensions. While the European...... Union clearly supports the formation and cross-border participation in these financial vehicles by adopting EU regulatory framework, the EU has also decided to determine a common investment decision standard to be used in all Member States, called the Prudent Person Principle. According...... to this principle, the fund - the future retirement for many - shall be managed with care, the skill of an expert, prudence and due diligence. Under this principle, the pension fund’s governing body is given a broad authority to invest the pension assets in a prudent fashion in light of the particular investment...... plan of a fund. At the same time, the EU is also moving towards more Responsible Investment and inclusion of the ESG-principles (Environment, Social and Governance). The question we aim to answer in this paper is how these two principles co-exist and whether, due to the new Directive adopted...

Identifiers for the 21st century: How to design, provision, and reuse persistent identifiers to maximize utility and impact of life science data

DEFF Research Database (Denmark)

McMurry, Julie A; Juty, Nick; Blomberg, Niklas

2017-01-01

, there is a need for increased awareness about how to avoid and manage common identifier problems, especially those related to persistence and web-accessibility/resolvability. We focus strongly on web-based identifiers in the life sciences; however, the principles are broadly relevant to other disciplines.......In many disciplines, data are highly decentralized across thousands of online databases (repositories, registries, and knowledgebases). Wringing value from such databases depends on the discipline of data science and on the humble bricks and mortar that make integration possible; identifiers...

Control room philosophy: Principles of control room design and control room work

International Nuclear Information System (INIS)

Skriver, Jan; Ramberg, Jasmine; Allwin, Pernilla

2006-01-01

In order to provide insights for improvement of work in control rooms several factors have to be considered. Knowledge of principles including control room philosophies will guide the recommended improvements. In addition to knowledge about specific principles an advantage for an organization can be an understanding of similarities and policies used in other high risk industry. The report has been developed on the basis of a document analysis of international standards and other guiding documents. (NUREG 0711, ISO 11064, ISO 6385, IEC 60964). In addition to the document analysis which has strived to compare the documents to see similarities in important principals, experience from working with control room design, modifications and evaluations in other high risk industries has pervaded the report. Important principles have been identified which are recommended to be included in a control room philosophy. Many of these are similar to the principles identified in the international standards. An additional principal which is regarded as important is the utilization of Key Performance Indicators (KPI) which can be used as a measure to target preventative means. Further more it is critical that the control room philosophy is easy to access and comprehend for all users. One of the challenges that remain after having developed a control room philosophy is how to utilize it in the daily work situation. It is vital that the document remains as a living document, guiding the continual improvement of the control room in the various life cycle stages

Key principles for a national clinical decision support knowledge sharing framework: synthesis of insights from leading subject matter experts.

Science.gov (United States)

Kawamoto, Kensaku; Hongsermeier, Tonya; Wright, Adam; Lewis, Janet; Bell, Douglas S; Middleton, Blackford

2013-01-01

To identify key principles for establishing a national clinical decision support (CDS) knowledge sharing framework. As part of an initiative by the US Office of the National Coordinator for Health IT (ONC) to establish a framework for national CDS knowledge sharing, key stakeholders were identified. Stakeholders' viewpoints were obtained through surveys and in-depth interviews, and findings and relevant insights were summarized. Based on these insights, key principles were formulated for establishing a national CDS knowledge sharing framework. Nineteen key stakeholders were recruited, including six executives from electronic health record system vendors, seven executives from knowledge content producers, three executives from healthcare provider organizations, and three additional experts in clinical informatics. Based on these stakeholders' insights, five key principles were identified for effectively sharing CDS knowledge nationally. These principles are (1) prioritize and support the creation and maintenance of a national CDS knowledge sharing framework; (2) facilitate the development of high-value content and tooling, preferably in an open-source manner; (3) accelerate the development or licensing of required, pragmatic standards; (4) acknowledge and address medicolegal liability concerns; and (5) establish a self-sustaining business model. Based on the principles identified, a roadmap for national CDS knowledge sharing was developed through the ONC's Advancing CDS initiative. The study findings may serve as a useful guide for ongoing activities by the ONC and others to establish a national framework for sharing CDS knowledge and improving clinical care.

Fundamental Safety Principles

International Nuclear Information System (INIS)

Abdelmalik, W.E.Y.

2011-01-01

This work presents a summary of the IAEA Safety Standards Series publication No. SF-1 entitled F UDAMENTAL Safety PRINCIPLES p ublished on 2006. This publication states the fundamental safety objective and ten associated safety principles, and briefly describes their intent and purposes. Safety measures and security measures have in common the aim of protecting human life and health and the environment. These safety principles are: 1) Responsibility for safety, 2) Role of the government, 3) Leadership and management for safety, 4) Justification of facilities and activities, 5) Optimization of protection, 6) Limitation of risks to individuals, 7) Protection of present and future generations, 8) Prevention of accidents, 9)Emergency preparedness and response and 10) Protective action to reduce existing or unregulated radiation risks. The safety principles concern the security of facilities and activities to the extent that they apply to measures that contribute to both safety and security. Safety measures and security measures must be designed and implemented in an integrated manner so that security measures do not compromise safety and safety measures do not compromise security.

The base rate principle and the fairness principle in social judgment.

Science.gov (United States)

Cao, Jack; Banaji, Mahzarin R

2016-07-05

Meet Jonathan and Elizabeth. One person is a doctor and the other is a nurse. Who is the doctor? When nothing else is known, the base rate principle favors Jonathan to be the doctor and the fairness principle favors both individuals equally. However, when individuating facts reveal who is actually the doctor, base rates and fairness become irrelevant, as the facts make the correct answer clear. In three experiments, explicit and implicit beliefs were measured before and after individuating facts were learned. These facts were either stereotypic (e.g., Jonathan is the doctor, Elizabeth is the nurse) or counterstereotypic (e.g., Elizabeth is the doctor, Jonathan is the nurse). Results showed that before individuating facts were learned, explicit beliefs followed the fairness principle, whereas implicit beliefs followed the base rate principle. After individuating facts were learned, explicit beliefs correctly aligned with stereotypic and counterstereotypic facts. Implicit beliefs, however, were immune to counterstereotypic facts and continued to follow the base rate principle. Having established the robustness and generality of these results, a fourth experiment verified that gender stereotypes played a causal role: when both individuals were male, explicit and implicit beliefs alike correctly converged with individuating facts. Taken together, these experiments demonstrate that explicit beliefs uphold fairness and incorporate obvious and relevant facts, but implicit beliefs uphold base rates and appear relatively impervious to counterstereotypic facts.

Design principles for a large RFP experiment

International Nuclear Information System (INIS)

Phillpott, J.; Rostagni, G.; Di Marco, J.

1981-01-01

An RFP experiment (RFX) has been designed by an International Design Team, by groups of collaborating physicists and engineers working in their home laboratories. This international collaborative project has been brought to an advanced stage of system and component design by the co-operation of three design teams under the co-ordination of a Design Manager, based at Culham Laboratory. The paper summaries the important design principles for an RFP device, based on the outcome of this collaborative design project

General principles of antimicrobial therapy.

Science.gov (United States)

Leekha, Surbhi; Terrell, Christine L; Edson, Randall S

2011-02-01

Antimicrobial agents are some of the most widely, and often injudiciously, used therapeutic drugs worldwide. Important considerations when prescribing antimicrobial therapy include obtaining an accurate diagnosis of infection; understanding the difference between empiric and definitive therapy; identifying opportunities to switch to narrow-spectrum, cost-effective oral agents for the shortest duration necessary; understanding drug characteristics that are peculiar to antimicrobial agents (such as pharmacodynamics and efficacy at the site of infection); accounting for host characteristics that influence antimicrobial activity; and in turn, recognizing the adverse effects of antimicrobial agents on the host. It is also important to understand the importance of antimicrobial stewardship, to know when to consult infectious disease specialists for guidance, and to be able to identify situations when antimicrobial therapy is not needed. By following these general principles, all practicing physicians should be able to use antimicrobial agents in a responsible manner that benefits both the individual patient and the community.

Le Chatelier's principle in sensation and perception: fractal-like enfolding at different scales

Directory of Open Access Journals (Sweden)

Ken Norwich

2010-06-01

Full Text Available Le Chatelier’s principle asserts that a disturbance, when applied to a resting system may drive the system away from its equilibrium state, but will invoke a countervailing influence that will counteract the effect of the disturbance. When applied to the field of sensation and perception, a generalized stimulus will displace the system from equilibrium, and a generalized adaptation process will serve as the countervailing influence tending to reduce the impact of the stimulus. The principle applies at all levels, from the behavioral to the neural, the larger enfolding the smaller in fractal-like form. Le Chatelier’s principle, so applied, leads to the unification of many concepts in sensory science. Ideas as diverse as sensory adaptation, reflex arcs, and simple deductive logic can be brought under the umbrella of a single orienting principle. Beyond unification, this principle allows us to approach many questions in pathophysiology from a different perspective. For example, we find new direction toward the reduction of phantom limb pain and possibly of vertigo.

Productivity limits and potentials of the principles of conservation agriculture.

Science.gov (United States)

Pittelkow, Cameron M; Liang, Xinqiang; Linquist, Bruce A; van Groenigen, Kees Jan; Lee, Juhwan; Lundy, Mark E; van Gestel, Natasja; Six, Johan; Venterea, Rodney T; van Kessel, Chris

2015-01-15

One of the primary challenges of our time is to feed a growing and more demanding world population with reduced external inputs and minimal environmental impacts, all under more variable and extreme climate conditions in the future. Conservation agriculture represents a set of three crop management principles that has received strong international support to help address this challenge, with recent conservation agriculture efforts focusing on smallholder farming systems in sub-Saharan Africa and South Asia. However, conservation agriculture is highly debated, with respect to both its effects on crop yields and its applicability in different farming contexts. Here we conduct a global meta-analysis using 5,463 paired yield observations from 610 studies to compare no-till, the original and central concept of conservation agriculture, with conventional tillage practices across 48 crops and 63 countries. Overall, our results show that no-till reduces yields, yet this response is variable and under certain conditions no-till can produce equivalent or greater yields than conventional tillage. Importantly, when no-till is combined with the other two conservation agriculture principles of residue retention and crop rotation, its negative impacts are minimized. Moreover, no-till in combination with the other two principles significantly increases rainfed crop productivity in dry climates, suggesting that it may become an important climate-change adaptation strategy for ever-drier regions of the world. However, any expansion of conservation agriculture should be done with caution in these areas, as implementation of the other two principles is often challenging in resource-poor and vulnerable smallholder farming systems, thereby increasing the likelihood of yield losses rather than gains. Although farming systems are multifunctional, and environmental and socio-economic factors need to be considered, our analysis indicates that the potential contribution of no-till to the

Variational principles

CERN Document Server

Moiseiwitsch, B L

2004-01-01

This graduate-level text's primary objective is to demonstrate the expression of the equations of the various branches of mathematical physics in the succinct and elegant form of variational principles (and thereby illuminate their interrelationship). Its related intentions are to show how variational principles may be employed to determine the discrete eigenvalues for stationary state problems and to illustrate how to find the values of quantities (such as the phase shifts) that arise in the theory of scattering. Chapter-by-chapter treatment consists of analytical dynamics; optics, wave mecha

INNOVATION LEAN PRINCIPLES IN AUTOMOTIVE GREEN MANUFACTURING

Directory of Open Access Journals (Sweden)

Dušan Sabadka

2014-12-01

Full Text Available Today, industries such as automotive and manufacturing industries deal with a lot of environmental regulations. Lean is a production strategy whose fundamental principles drive the industry towards a more effective production of goods and services. The eco-efficiency concept is primary to sustainable development and intends to provide more value with less environmental impact. The aim of this study is to identify and explore the contributions of Lean to reduce environmental impacts that naturally result from industrial activity.

First-principles study of the nickel–silicon binary compounds under pressure

Energy Technology Data Exchange (ETDEWEB)

Zhao, Yuhong, E-mail: zyh388@sina.com [College of Materials Science and Engineering, North University of China, Taiyuan 030051 (China); Hou, Hua [College of Materials Science and Engineering, North University of China, Taiyuan 030051 (China); Zhao, Yuhui [Department of Mechanical and Electronic Engineering, Hebei College of Industry and Technology, Shijiazhuang 050091 (China); Han, Peide [College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024 (China)

2015-08-15

Highlights: • The structural and elastic properties of Ni–Si system under pressure are firstly studied. • The lattice parameters of NiSi{sub 2} are the most sensitive to external pressure change. • Ni{sub 3}Si, Ni{sub 31}Si{sub 12}, Ni{sub 2}Si (δ) and Ni{sub 3}Si{sub 2} are mechanical stability with pressure up to 50 GPa. • The hardness of the four compounds can be improved by increasing pressure. • Electronic structures are analyzed to understand pressure effect on the seven compounds. - Abstract: The effects of high pressure on structural, stable, elastic, thermodynamic properties and electronic structures of Ni–Si binary compounds (i.e. β-Ni{sub 3}Si, γ-Ni{sub 31}Si{sub 12}, δ-Ni{sub 2}Si, θ-Ni{sub 2}Si, ε-Ni{sub 3}Si{sub 2}, ε-NiSi and α-NiSi{sub 2}) have been firstly studied by first-principles calculation based on density functional theory method within generalized gradient approximation. The calculated lattice parameters of the seven compounds at zero pressure and zero temperature agree well with the available experimental values and previous theoretical data. The values of V/V{sub 0} decrease with pressure going up to 50 GPa and the rate of change decrease gradually. The lattice parameters of NiSi{sub 2} are the most sensitive to external pressure change. Ni{sub 3}Si, Ni{sub 31}Si{sub 12}, Ni{sub 2}Si (δ) and Ni{sub 3}Si{sub 2} are mechanical stability by estimating stability criteria with pressure ranging from 0 to 50 GPa. But Ni{sub 2}Si (θ), NiSi and NiSi{sub 2} are not mechanically stable with pressure up to 10, 40 and 30 GPa, respectively. The calculated results of bulk modulus B, shear modulus G and Young’s modulus E illustrate pressure can improve the hardness of Ni{sub 3}Si, Ni{sub 31}Si{sub 12}, Ni{sub 2}Si (δ) and Ni{sub 3}Si{sub 2} compounds. In addition, ratio of shear modulus to bulk modulus G/B shows that all the considered compounds are ductile materials except NiSi. The Debye temperature Θ{sub D} of Ni{sub 3}Si

Supply Chain Control Principles in Local Food Production: A Norwegian Case Study

Directory of Open Access Journals (Sweden)

Heidi C. Dreyer

2014-08-01

Full Text Available Based on an analysis of the supply chain of four producers of local specialty foods, we explore how planning and control principles can be applied to align supply chain capabilities and market requirements. It has been shown that local food struggles with market access, and that the supply chain is one of the obstacles preventing local food producers from gaining a solid market position. We identify a number of features of the local food chain, analyse the obstacles and develop generic designs and control principles for local food producers.

Inferring principles for sustainable development of business through analogies from ecological systems

Directory of Open Access Journals (Sweden)

K. Sriram

2013-03-01

Full Text Available The literature in the field of sustainable development (SD of businesses is piecemeal and diverse. This paper identifies and integrates principles that businesses could use for transformation towards SD. This is done through analogical reasoning from the source context of ecological systems to the target contexts of business socio-economic systems and machine/technology systems. The methodologies of systems thinking and morphological analysis supplement the analogical reasoning. Based on this, twelve principles for sustainable development of business are inferred for business managers and policy makers.

4. Principles of Art from Antiquity to Contemporary Pedagogy in the Context of Methodology of Art Education

Directory of Open Access Journals (Sweden)

Olimpiada Arbuz-Spatari

2016-03-01

Full Text Available The methodologies of Art Education is a system of educational documents - principles, rules, methods, procedures, forms - designed determinative - reflective thinking from teleology, content, communication arts / cultural / scientific, reception and receiver topic communicating, and are subject oriented educated / creator student under the laws of education, communication and artistic principles.

Key principles for adapting South African settlement patterns to climate change

CSIR Research Space (South Africa)

Van Wyk, Llewellyn

2017-06-01

Full Text Available The aim of the paper is to identify key principles for adapting SA settlement patterns to climate change. Section 1 reviews the range of climate-related impacts likely to affect SA settlements using climate change models and scenarios as a context...

Guiding principles for student leadership development in the doctor of pharmacy program to assist administrators and faculty members in implementing or refining curricula.

Science.gov (United States)

Traynor, Andrew P; Boyle, Cynthia J; Janke, Kristin K

2013-12-16

To assist administrators and faculty members in colleges and schools of pharmacy by gathering expert opinion to frame, direct, and support investments in student leadership development. Twenty-six leadership instructors participated in a 3-round, online, modified Delphi process to define doctor of pharmacy (PharmD) student leadership instruction. Round 1 asked open-ended questions about leadership knowledge, skills, and attitudes to begin the generation of student leadership development guiding principles and competencies. Statements were identified as guiding principles when they were perceived as foundational to the instructional approach. Round 2 grouped responses for agreement rating and comment. Group consensus with a statement as a guiding principle was set prospectively at 80%. Round 3 allowed rating and comment on guidelines, modified from feedback in round 2, that did not meet consensus. The principles were verified by identifying common contemporary leadership development approaches in the literature. Twelve guiding principles, related to concepts of leadership and educational philosophy, were defined and could be linked to contemporary leadership development thought. These guiding principles describe the motivation for teaching leadership, the fundamental precepts of student leadership development, and the core tenets for leadership instruction. Expert opinion gathered using a Delphi process resulted in guiding principles that help to address many of the fundamental questions that arise when implementing or refining leadership curricula. The principles identified are supported by common contemporary leadership development thought.

Identifying Food Safety Concerns when Communication Barriers Exist

Science.gov (United States)

Neal, Jack A.; Dawson, Mary; Madera, Juan M.

2011-01-01

Abstract: Students must be prepared to lead a diverse workforce. The objective of this study was to establish a teaching method that helps students identify barriers to food safety while working in a simulated environment with communication barriers. This study employed a perspective taking exercise based upon the principles of social learning…

Theory of group extension, Shubnikov-Curie principle and phase transformations

International Nuclear Information System (INIS)

Koptsik, V.A.; Talis, A.L.

1983-01-01

It is shown, that the generalized Curie principle (GCP) is the principle of nondecreasing abstract symmetry under structural transformations in (quasi) isolated physical systems. Asymmetry of such systems at any structural level is compensated by their symmetrization at another one, transformation of the old and appearance of qualitatively new symmetries. A corresponding situation is preserved also at the description level (mathematical simulation) of physical systems. Structural levels of substance arrangement and forms of connection between them, reflected by the Shubnikov-Curie (SCP) and GCP are inexhaustible. With the discovery of new structural levels and new forms of relations between them can be discovered and new forms of SCP, which can not be exhausted in the given work

The precautionary principle: is it safe.

Science.gov (United States)

Gignon, Maxime; Ganry, Olivier; Jardé, Olivier; Manaouil, Cécile

2013-06-01

The precautionary principle is generally acknowledged to be a powerful tool for protecting health but it was originally invoked by policy makers for dealing with environmental issues. In the 1990s, the principle was incorporated into many legislative and regulatory texts in international law. One can consider that the precautionary principle has turned into "precautionism" necessary to prove to the people, taking account of risk in decisions. There is now a risk that these abuses will deprive the principle of its meaning and value. When pushed to its limits, the precautionary principle can even be dangerous when applied to the healthcare field. This is why a critical analysis of the principle is necessary. Through the literature, it sometimes seems to deviate somehow from the essence of the precautionary principle as it is commonly used in relation to health. We believe that educational work is necessary to familiarize professionals, policy makers and public opinion of the precautionary principle and avoid confusion. We propose a critical analysis of the use and misuse of the precautionary principle.

Principles of nuclear magnetic resonance (NMR) - current state of the art

International Nuclear Information System (INIS)

Lerski, R.A.

1985-01-01

Nuclear magnetic resonance (NMR) imaging has progressed rapidly from laboratory curiosity to commercial exploitation and clinical application in the space of only three years. The physical principles underlying the technique are described and the equipment requirements outlined. The question of optimal magnetic field strength is discussed. (author)

The principle of general tovariance

NARCIS (Netherlands)

Heunen, C.; Landsman, N.P.; Spitters, B.A.W.; Loja Fernandes, R.; Picken, R.

2008-01-01

We tentatively propose two guiding principles for the construction of theories of physics, which should be satisfied by a possible future theory of quantum gravity. These principles are inspired by those that led Einstein to his theory of general relativity, viz. his principle of general covariance

Fundamental Principle for Quantum Theory

OpenAIRE

Khrennikov, Andrei

2002-01-01

We propose the principle, the law of statistical balance for basic physical observables, which specifies quantum statistical theory among all other statistical theories of measurements. It seems that this principle might play in quantum theory the role that is similar to the role of Einstein's relativity principle.

48 CFR 49.113 - Cost principles.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Cost principles. 49.113 Section 49.113 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.113 Cost principles. The cost principles and procedures in the...

The anthropic principle

International Nuclear Information System (INIS)

Carr, B.J.

1982-01-01

The anthropic principle (the conjecture that certain features of the world are determined by the existence of Man) is discussed with the listing of the objections, and is stated that nearly all the constants of nature may be determined by the anthropic principle which does not give exact values for the constants but only their orders of magnitude. (J.T.)

Biomechanics principles and practices

CERN Document Server

Peterson, Donald R

2014-01-01

Presents Current Principles and ApplicationsBiomedical engineering is considered to be the most expansive of all the engineering sciences. Its function involves the direct combination of core engineering sciences as well as knowledge of nonengineering disciplines such as biology and medicine. Drawing on material from the biomechanics section of The Biomedical Engineering Handbook, Fourth Edition and utilizing the expert knowledge of respected published scientists in the application and research of biomechanics, Biomechanics: Principles and Practices discusses the latest principles and applicat

General Principles of Transnationalised Criminal Justice?
Exploratory Reflections

Directory of Open Access Journals (Sweden)

Marianne L. Wade

2013-09-01

Full Text Available This article sets out to explore the premise of general principles in what is labelled transnationalised criminal justice (encompassing the substantive and procedural law as well as the institutions of transnational criminal law and European criminal law. Whilst there can be no denying that these are diverse and divergent areas of law in many ways, their fundamental common denominator of seeking to convict individuals whilst subjecting these to arrest, detention and deprivation of other rights across borders, is taken as a baseline around which certain general principles may gravitate. The current state of executive over-reach within transnationalised criminal justice structures is studied, particularly in relation to the European criminal justice context. This over-reach is explored utilising the theoretical framework of social contract theory. It is suggested that the transfer of investigative and prosecutorial powers to transnationalised contexts undertaken by the relevant executives without seeking to temper this assignment with mechanisms to secure the rights of individuals which counter-balance these, as required by the constitutional traditions of their country, can be regarded as in breach of the social contract. Using this thought experiment, this article provides a framework with which to identify the deficits of transnationalised criminal law.  The way in which such deficits undermine the legitimacy of the institutions created by states to operate the mechanisms of transnationalised criminal justice as well as the fundamental values of their own constitutions is, however, demonstrated as concrete. The latter are identified as mechanisms for deducing the general principles of transnationalised criminal justice (albeit via difficult international negotiation. If the supranationalisation of criminal justice powers is not to be regarded as a tool undermining constitutional values and effectively allowing executives acting in an

PRINCIPLES OF CONTENT FORMATION EDUCATIONAL ELECTRONIC RESOURCE

Directory of Open Access Journals (Sweden)

О Ю Заславская

2017-12-01

Full Text Available The article considers modern possibilities of information and communication technologies for the design of electronic educational resources. The conceptual basis of the open educational multimedia system is based on the modular architecture of the electronic educational resource. The content of the electronic training module can be implemented in several versions of the modules: obtaining information, practical exercises, control. The regularities in the teaching process in modern pedagogical theory are considered: general and specific, and the principles for the formation of the content of instruction at different levels are defined, based on the formulated regularities. On the basis of the analysis, the principles of the formation of the electronic educational resource are determined, taking into account the general and didactic patterns of teaching.As principles of the formation of educational material for obtaining information for the electronic educational resource, the article considers: the principle of methodological orientation, the principle of general scientific orientation, the principle of systemic nature, the principle of fundamentalization, the principle of accounting intersubject communications, the principle of minimization. The principles of the formation of the electronic training module of practical studies in the article include: the principle of systematic and dose based consistency, the principle of rational use of study time, the principle of accessibility. The principles of the formation of the module for monitoring the electronic educational resource can be: the principle of the operationalization of goals, the principle of unified identification diagnosis.

Quantum principles in field interactions

International Nuclear Information System (INIS)

Shirkov, D.V.

1986-01-01

The concept of quantum principle is intruduced as a principle whosee formulation is based on specific quantum ideas and notions. We consider three such principles, viz. those of quantizability, local gauge symmetry, and supersymmetry, and their role in the development of the quantum field theory (QFT). Concerning the first of these, we analyze the formal aspects and physical contents of the renormalization procedure in QFT and its relation to ultraviolet divergences and the renorm group. The quantizability principle is formulated as an existence condition of a self-consistent quantum version with a given mechanism of the field interaction. It is shown that the consecutive (from a historial point of view) use of these quantum principles puts still larger limitations on possible forms of field interactions

Understanding and applying principles of social cognition and ...

Science.gov (United States)

Environmental governance systems are under greater pressure to adapt and to cope with increased social and ecological uncertainty from stressors like climate change. We review principles of social cognition and decision making that shape and constrain how environmental governance systems adapt. We focus primarily on the interplay between key decision makers in society and legal systems. We argue that adaptive governance must overcome three cooperative dilemmas to facilitate adaptation: (1) encouraging collaborative problem solving, (2) garnering social acceptance and commitment, and (3) cultivating a culture of trust and tolerance for change and uncertainty. However, to do so governance systems must cope with biases in people’s decision making that cloud their judgment and create conflict. These systems must also satisfy people’s fundamental needs for self-determination, fairness, and security, ensuring that changes to environmental governance are perceived as legitimate, trustworthy, and acceptable. We discuss the implications of these principles for common governance solutions (e.g., public participation, enforcement) and conclude with methodological recommendations. We outline how scholars can investigate the social cognitive principles involved in cases of adaptive governance. Social-ecological stressors place significant pressure on major societal systems, triggering adaptive reforms in human governance and environmental law. Though potentially benefici

Boron Fullerenes: A First-Principles Study

Directory of Open Access Journals (Sweden)

Gonzalez Szwacki Nevill

2007-01-01

Full Text Available AbstractA family of unusually stable boron cages was identified and examined using first-principles local-density functional method. The structure of the fullerenes is similar to that of the B12icosahedron and consists of six crossing double-rings. The energetically most stable fullerene is made up of 180 boron atoms. A connection between the fullerene family and its precursors, boron sheets, is made. We show that the most stable boron sheets are not necessarily precursors of very stable boron cages. Our finding is a step forward in the understanding of the structure of the recently produced boron nanotubes.

The role of ethics and principles

International Nuclear Information System (INIS)

Clarke, R.H.

2002-01-01

There has been a hundred-year history of the uses of radiation in medicine and industry. Throughout that time there has also been advice on the need to protect people from the hazards associated with exposure. This paper traces the evolution of protection standards through the differing phases that are identified. These phases reflect changes both in scientific understanding of the biological effects of exposure and of the social and ethical standards to be applied. As a result, the principles used for protection have continuously evolved and are likely to continue to do so in the future. (author)

Principles of project management

Science.gov (United States)

1982-01-01

The basic principles of project management as practiced by NASA management personnel are presented. These principles are given as ground rules and guidelines to be used in the performance of research, development, construction or operational assignments.

Modern electronic maintenance principles

CERN Document Server

Garland, DJ

2013-01-01

Modern Electronic Maintenance Principles reviews the principles of maintaining modern, complex electronic equipment, with emphasis on preventive and corrective maintenance. Unfamiliar subjects such as the half-split method of fault location, functional diagrams, and fault finding guides are explained. This book consists of 12 chapters and begins by stressing the need for maintenance principles and discussing the problem of complexity as well as the requirements for a maintenance technician. The next chapter deals with the connection between reliability and maintenance and defines the terms fai

Developing principles of growth

DEFF Research Database (Denmark)

Neergaard, Helle; Fleck, Emma

of the principles of growth among women-owned firms. Using an in-depth case study methodology, data was collected from women-owned firms in Denmark and Ireland, as these countries are similar in contextual terms, e.g. population and business composition, dominated by micro, small and medium-sized enterprises....... Extending on principles put forward in effectuation theory, we propose that women grow their firms according to five principles which enable women’s enterprises to survive in the face of crises such as the current financial world crisis....

GAUGE PRINCIPLE AND VARIATIONAL FORMULATION FOR FLOWS OF AN IDEAL FLUID

Institute of Scientific and Technical Information of China (English)

KAMBE Tsutomu

2003-01-01

A gauge principle is applied to mass flows of an ideal compressible fluid subject to Galilei transformation. A free-field Lagrangian defined at the outset is invariant with respect to global SO(3) gauge transformations as well as Galilei transformations. The action principle leads to the equation of potential flows under constraint of a continuity equation. However, the irrotational flow is not invariant with respect to local SO(3) gauge transformations. According to the gauge principle,a gauge-covariant derivative is defined by introducing a new gauge field. Galilei invariance of the derivative requires the gauge field to coincide with the vorticity, i.e. the curl of the velocity field. A full gauge-covariant variational formulation is proposed on the basis of the Hamilton's principle and an assoicated Lagrangian. By means of an isentropic material variation taking into account individual particle motion, the Euler's equation of motion is derived for isentropic flows by using the covariant derivative. Noether's law associated with global SO(3) gauge invariance leads to the conservation of total angular momentum. In addition, the Lagrangian has a local symmetry of particle permutation which results in local conservation law equivalent to the vorticity equation.

State vector labelling problem: a review of structural principles

International Nuclear Information System (INIS)

Louck, J.D.

1976-01-01

The technique of labeling state vectors by use of the simultaneous eigenvalues of a complete set of commuting Hermitian operators stems from the early days of quantum theory. In sharp contrast to the classical method, there stands the nonorthogonal bases methods of Moshinsky and Bargmann and the null space methods of Biedenharn and Louck. The structural principles underlying these various methods are presented and discussed. 2 figures

Shade guide optimization--a novel shade arrangement principle for both ceramic and composite shade guides when identifying composite test objects.

Science.gov (United States)

Østervemb, Niels; Jørgensen, Jette Nedergaard; Hørsted-Bindslev, Preben

2011-02-01

The most widely used shade guide for composite materials is made of ceramic and arranged according to a non-proven method. There is a need for a composite shade guide using a scientifically based arrangement principle. To compare the shade tab arrangement of the Vitapan Classical shade guide and an individually made composite shade guide using both the originally proposed arrangement principle and arranged according to ΔE2000 values with hue group division. An individual composite shade guide made from Filtek Supreme XT body colors was compared to the Vitapan Classical shade guide. Twenty-five students matched color samples made from Filtek Supreme XT body colors using the two shade guides arranged after the two proposed principles--four shade guides in total. Age, sequence, gender, time, and number of correct matches were recorded. The proposed visually optimal composite shade guide was both fastest and had the highest number of correct matches. Gender was significantly associated with time used for color sampling but not regarding the number of correct shade matches. A composite shade guide is superior compared to the ceramic Vitapan Classical guide when using composite test objects. A rearrangement of the shade guide according to hue, subdivided according to ΔE2000, significantly reduces the time needed to take a color sample and increases the number of correct shade matches. Total color difference in relation to the lightest tab with hue group division is recommended as a possible and universally applicable mode of tab arrangement in dental color standards. Moreover, a shade guide made of the composite materials itself is to be preferred as both a faster and more accurate method of determining color. © 2011, COPYRIGHT THE AUTHORS. JOURNAL COMPILATION © 2011, WILEY PERIODICALS, INC.

Fundamental principles of quantum theory

International Nuclear Information System (INIS)

Bugajski, S.

1980-01-01

After introducing general versions of three fundamental quantum postulates - the superposition principle, the uncertainty principle and the complementarity principle - the question of whether the three principles are sufficiently strong to restrict the general Mackey description of quantum systems to the standard Hilbert-space quantum theory is discussed. An example which shows that the answer must be negative is constructed. An abstract version of the projection postulate is introduced and it is demonstrated that it could serve as the missing physical link between the general Mackey description and the standard quantum theory. (author)

On the role of the equivalence principle in the general relativity theory

International Nuclear Information System (INIS)

Gertsenshtein, M.E.; Stanyukovich, K.P.; Pogosyan, V.A.

1977-01-01

The conditions under which the solutions of the general relativity theory equations satisfy the correspondence principle are considered. It is shown that in general relativity theory, as in a plane space any systems of coordinates satisfying the topological requirements of continuity and uniqueness are admissible. The coordinate transformations must be mutually unique, and the following requirements must be met: the transformations of the coordinates xsup(i)=xsup(i)(anti xsup(k)) must preserve the class of the function, while the transformation jacobian must be finite and nonzero. The admissible metrics in the Tolmen problem for a vacuum are considered. A prohibition of the vacuum solution of the Tolmen problem is obtained from the correspondence principle. The correspondence principle is applied to the solution of the Friedmann problem by constructing a spherical symmetric self-similar solution, in which replacement of compression by expansion occurs at a finite density. The examples adduced convince that the application of the correspondence principle makes it possible to discard physically inadmissible solutions and obtained new physical results

Fermat and the Minimum Principle

Indian Academy of Sciences (India)

Arguably, least action and minimum principles were offered or applied much earlier. This (or these) principle(s) is/are among the fundamental, basic, unifying or organizing ones used to describe a variety of natural phenomena. It considers the amount of energy expended in performing a given action to be the least required ...

32 CFR 203.6 - Cost principles.

Science.gov (United States)

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false Cost principles. 203.6 Section 203.6 National... Cost principles. (a) Non-profit contractors must comply with the cost principles in OMB Circular A-122...) For-profit contractors and subcontractors must comply with the cost principles in the FAR (48 CFR part...

7 CFR 3015.111 - Cost principles.

Science.gov (United States)

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Cost principles. 3015.111 Section 3015.111... § 3015.111 Cost principles. (a) The cost principles prescribed by subpart T of this part require prior... approvals required by the cost principles are in § 3015.196. Procedures for prior approvals required by this...

The traveltime holographic principle

Science.gov (United States)

Huang, Yunsong; Schuster, Gerard T.

2015-01-01

Fermat's interferometric principle is used to compute interior transmission traveltimes τpq from exterior transmission traveltimes τsp and τsq. Here, the exterior traveltimes are computed for sources s on a boundary B that encloses a volume V of interior points p and q. Once the exterior traveltimes are computed, no further ray tracing is needed to calculate the interior times τpq. Therefore this interferometric approach can be more efficient than explicitly computing interior traveltimes τpq by ray tracing. Moreover, the memory requirement of the traveltimes is reduced by one dimension, because the boundary B is of one fewer dimension than the volume V. An application of this approach is demonstrated with interbed multiple (IM) elimination. Here, the IMs in the observed data are predicted from the migration image and are subsequently removed by adaptive subtraction. This prediction is enabled by the knowledge of interior transmission traveltimes τpq computed according to Fermat's interferometric principle. We denote this principle as the `traveltime holographic principle', by analogy with the holographic principle in cosmology where information in a volume is encoded on the region's boundary.

Sovereignty, Stability and Solidarity: Conflicting and Converging Principles and the Shaping of Economic Governance in the European Union

NARCIS (Netherlands)

van den Brink, Ton|info:eu-repo/dai/nl/269465995; van Rossem, Jan Willem|info:eu-repo/dai/nl/32439649X

2014-01-01

The central aim of this paper is to identify the content of the principles of stability, national sovereignty and solidarity and to analyse how these principles interact with regard to EU economic governance. The first prong of this paper research is largely conceptual in nature and looks at the

Principles for School Drug Education

Science.gov (United States)

Meyer, Lois

2004-01-01

This document presents a revised set of principles for school drug education. The principles for drug education in schools comprise an evolving framework that has proved useful over a number of decades in guiding the development of effective drug education. The first edition of "Principles for Drug Education in Schools" (Ballard et al.…

Hamilton's principle for beginners

International Nuclear Information System (INIS)

Brun, J L

2007-01-01

I find that students have difficulty with Hamilton's principle, at least the first time they come into contact with it, and therefore it is worth designing some examples to help students grasp its complex meaning. This paper supplies the simplest example to consolidate the learning of the quoted principle: that of a free particle moving along a line. Next, students are challenged to add gravity to reinforce the argument and, finally, a two-dimensional motion in a vertical plane is considered. Furthermore these examples force us to be very clear about such an abstract principle

Principles underlying the design of "The Number Race", an adaptive computer game for remediation of dyscalculia

Directory of Open Access Journals (Sweden)

Cohen Laurent

2006-05-01

Full Text Available Abstract Background Adaptive game software has been successful in remediation of dyslexia. Here we describe the cognitive and algorithmic principles underlying the development of similar software for dyscalculia. Our software is based on current understanding of the cerebral representation of number and the hypotheses that dyscalculia is due to a "core deficit" in number sense or in the link between number sense and symbolic number representations. Methods "The Number Race" software trains children on an entertaining numerical comparison task, by presenting problems adapted to the performance level of the individual child. We report full mathematical specifications of the algorithm used, which relies on an internal model of the child's knowledge in a multidimensional "learning space" consisting of three difficulty dimensions: numerical distance, response deadline, and conceptual complexity (from non-symbolic numerosity processing to increasingly complex symbolic operations. Results The performance of the software was evaluated both by mathematical simulations and by five weeks of use by nine children with mathematical learning difficulties. The results indicate that the software adapts well to varying levels of initial knowledge and learning speeds. Feedback from children, parents and teachers was positive. A companion article 1 describes the evolution of number sense and arithmetic scores before and after training. Conclusion The software, open-source and freely available online, is designed for learning disabled children aged 5–8, and may also be useful for general instruction of normal preschool children. The learning algorithm reported is highly general, and may be applied in other domains.

Guiding Principles for Student Leadership Development in the Doctor of Pharmacy Program to Assist Administrators and Faculty Members in Implementing or Refining Curricula

Science.gov (United States)

Boyle, Cynthia J.; Janke, Kristin K.

2013-01-01

Objective. To assist administrators and faculty members in colleges and schools of pharmacy by gathering expert opinion to frame, direct, and support investments in student leadership development. Methods. Twenty-six leadership instructors participated in a 3-round, online, modified Delphi process to define doctor of pharmacy (PharmD) student leadership instruction. Round 1 asked open-ended questions about leadership knowledge, skills, and attitudes to begin the generation of student leadership development guiding principles and competencies. Statements were identified as guiding principles when they were perceived as foundational to the instructional approach. Round 2 grouped responses for agreement rating and comment. Group consensus with a statement as a guiding principle was set prospectively at 80%. Round 3 allowed rating and comment on guidelines, modified from feedback in round 2, that did not meet consensus. The principles were verified by identifying common contemporary leadership development approaches in the literature. Results. Twelve guiding principles, related to concepts of leadership and educational philosophy, were defined and could be linked to contemporary leadership development thought. These guiding principles describe the motivation for teaching leadership, the fundamental precepts of student leadership development, and the core tenets for leadership instruction. Conclusions. Expert opinion gathered using a Delphi process resulted in guiding principles that help to address many of the fundamental questions that arise when implementing or refining leadership curricula. The principles identified are supported by common contemporary leadership development thought. PMID:24371345

Nonextensive entropies derived from Gauss' principle

International Nuclear Information System (INIS)

Wada, Tatsuaki

2011-01-01

Gauss' principle in statistical mechanics is generalized for a q-exponential distribution in nonextensive statistical mechanics. It determines the associated stochastic and statistical nonextensive entropies which satisfy Greene-Callen principle concerning on the equivalence between microcanonical and canonical ensembles. - Highlights: → Nonextensive entropies are derived from Gauss' principle and ensemble equivalence. → Gauss' principle is generalized for a q-exponential distribution. → I have found the condition for satisfying Greene-Callen principle. → The associated statistical q-entropy is found to be normalized Tsallis entropy.

Towards identifying the mechanisms underlying field-aligned edge-loss of HHFW power on NSTX

International Nuclear Information System (INIS)

Perkins, R. J.; Bell, R. E.; Bertelli, N.; Diallo, A.; Gerhardt, S.; Hosea, J. C.; Jaworski, M. A.; LeBlanc, B. P.; Kramer, G. J.; Maingi, R.; Phillips, C. K.; Podestà, M.; Roquemore, L.; Scotti, F.; Taylor, G.; Wilson, J. R.; Ahn, J-W.; Gray, T. K.; Green, D. L.; McLean, A.

2014-01-01

Fast-wave heating will be a major heating scheme on ITER, as it can heat ions directly and is relatively unaffected by the large machine size unlike neutral beams. However, fast-wave interactions with the plasma edge can lead to deleterious effects such as, in the case of the high-harmonic fast-wave (HHFW) system on NSTX, large losses of fast-wave power in the scrape off layer (SOL) under certain conditions. In such scenarios, a large fraction of the lost HHFW power is deposited on the upper and lower divertors in bright spiral shapes. The responsible mechanism(s) has not yet been identified but may include fast-wave propagation in the scrape off layer, parametric decay instability, and RF currents driven by the antenna reactive fields. Understanding and mitigating these losses is important not only for improving the heating and current-drive on NSTX-Upgrade but also for understanding fast-wave propagation across the SOL in any fast-wave system. This talk summarizes experimental results demonstrating that the flow of lost HHFW power to the divertor regions largely follows the open SOL magnetic field lines. This lost power flux is relatively large close to both the antenna and the last closed flux surface with a reduced level in between, so the loss mechanism cannot be localized to the antenna. At the same time, significant losses also occur along field lines connected to the inboard edge of the bottom antenna plate. The power lost within the spirals is roughly estimated, showing that these field-aligned losses to the divertor are significant but may not account for the total HHFW loss. To elucidate the role of the onset layer for perpendicular fast-wave propagation with regards to fast-wave propagation in the SOL, a cylindrical cold-plasma model is being developed. This model, in addition to advanced RF codes such as TORIC and AORSA, is aimed at identifying the underlying mechanism(s) behind these SOL losses, to minimize their effects in NSTX-U, and to predict

Towards identifying the mechanisms underlying field-aligned edge-loss of HHFW power on NSTX

Energy Technology Data Exchange (ETDEWEB)

Perkins, R. J.; Bell, R. E.; Bertelli, N.; Diallo, A.; Gerhardt, S.; Hosea, J. C.; Jaworski, M. A.; LeBlanc, B. P.; Kramer, G. J.; Maingi, R.; Phillips, C. K.; Podestà, M.; Roquemore, L.; Scotti, F.; Taylor, G.; Wilson, J. R. [Princeton Plasma Physics Laboratory, Princeton, NJ (United States); Ahn, J-W.; Gray, T. K.; Green, D. L.; McLean, A. [Oak Ridge National Laboratory, Oak Ridge, TN (United States); and others

2014-02-12

Fast-wave heating will be a major heating scheme on ITER, as it can heat ions directly and is relatively unaffected by the large machine size unlike neutral beams. However, fast-wave interactions with the plasma edge can lead to deleterious effects such as, in the case of the high-harmonic fast-wave (HHFW) system on NSTX, large losses of fast-wave power in the scrape off layer (SOL) under certain conditions. In such scenarios, a large fraction of the lost HHFW power is deposited on the upper and lower divertors in bright spiral shapes. The responsible mechanism(s) has not yet been identified but may include fast-wave propagation in the scrape off layer, parametric decay instability, and RF currents driven by the antenna reactive fields. Understanding and mitigating these losses is important not only for improving the heating and current-drive on NSTX-Upgrade but also for understanding fast-wave propagation across the SOL in any fast-wave system. This talk summarizes experimental results demonstrating that the flow of lost HHFW power to the divertor regions largely follows the open SOL magnetic field lines. This lost power flux is relatively large close to both the antenna and the last closed flux surface with a reduced level in between, so the loss mechanism cannot be localized to the antenna. At the same time, significant losses also occur along field lines connected to the inboard edge of the bottom antenna plate. The power lost within the spirals is roughly estimated, showing that these field-aligned losses to the divertor are significant but may not account for the total HHFW loss. To elucidate the role of the onset layer for perpendicular fast-wave propagation with regards to fast-wave propagation in the SOL, a cylindrical cold-plasma model is being developed. This model, in addition to advanced RF codes such as TORIC and AORSA, is aimed at identifying the underlying mechanism(s) behind these SOL losses, to minimize their effects in NSTX-U, and to predict

Who should do what in environmental management? Twelve principles for allocating responsibilities

NARCIS (Netherlands)

Mostert, E.

2015-01-01

In environmental management there is often discussion on the allocation of responsibilities. Such discussions can continue for a long time and can form an obstacle for effective action. In this article twelve normative principles for the allocation of responsibilities are identified, coming from

42 CFR 137.167 - What cost principles must a Self-Governance Tribe follow when participating in self-governance...

Science.gov (United States)

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false What cost principles must a Self-Governance Tribe follow when participating in self-governance under Title V? 137.167 Section 137.167 Public Health PUBLIC... HUMAN SERVICES TRIBAL SELF-GOVERNANCE Operational Provisions Audits and Cost Principles § 137.167 What...

State Water Resources Control Board, California Agreement in Principle 1995 summary report

International Nuclear Information System (INIS)

Laudon, L.

1996-03-01

The Agreement in Principle (AIP) was established as part of the Secretary of Energy's Ten-Point Initiative which was announced in 1989. One of the Secretary's goals was to integrate the Department of Energy's (DOE) national security mission with their environmental restoration and compliance responsibilities. In an effort to accomplish this goal, DOE increased the role of the states in the oversight of DOE's monitoring programs through AIPs. The State of California and DOE negotiated the California AIP beginning in 1989 and signed the Agreement in September 1990. The AIP identified six DOE facilities to be evaluated under the program. The six facilities evaluated by the AIP program were: (1) Lawrence Livermore National Laboratory (LLNL) including LLNL's Site 300; (2) Sandia National Laboratories, California (SNL/CA); (3) Lawrence Berkeley Laboratory (LBL); (4) Stanford Linear Accelerator Center (SLAC); (5) Energy Technology Engineering Center (ETEC); and (6) Laboratory for Energy-Related Health Research (LEHR)

State Water Resources Control Board, California Agreement in Principle 1995 summary report

Energy Technology Data Exchange (ETDEWEB)

Laudon, L.

1996-03-01

The Agreement in Principle (AIP) was established as part of the Secretary of Energy`s Ten-Point Initiative which was announced in 1989. One of the Secretary`s goals was to integrate the Department of Energy`s (DOE) national security mission with their environmental restoration and compliance responsibilities. In an effort to accomplish this goal, DOE increased the role of the states in the oversight of DOE`s monitoring programs through AIPs. The State of California and DOE negotiated the California AIP beginning in 1989 and signed the Agreement in September 1990. The AIP identified six DOE facilities to be evaluated under the program. The six facilities evaluated by the AIP program were: (1) Lawrence Livermore National Laboratory (LLNL) including LLNL`s Site 300; (2) Sandia National Laboratories, California (SNL/CA); (3) Lawrence Berkeley Laboratory (LBL); (4) Stanford Linear Accelerator Center (SLAC); (5) Energy Technology Engineering Center (ETEC); and (6) Laboratory for Energy-Related Health Research (LEHR).

Polluter-Pays-Principle: The Cardinal Instrument for Addressing Climate Change

Directory of Open Access Journals (Sweden)

Mizan R. Khan

2015-09-01

Full Text Available This article traces the evolution of polluter-pays-principle (PPP as an economic, ethical and legal instrument and argues that it has the potential of effecting global responsibility for adaptation and mitigation and for generating reliable funding for the purpose. However, the contradiction is that while it rests on neoliberal market principles, the UN Framework Convention on Climate Change did not include the PPP as its provision though the principle of “common but differentiated responsibility based on respective capabilities” (Article 3.1 implicitly recognizes this. The article raises the basic question that under a free-market global system: why should the polluters not take responsibility of their actions so that the global society does not suffer? The Organization of Economic Cooperation and Development (OECD countries apply this PPP in many of its forms. Some developing countries are also applying it albeit still more as a governmental rather than polluter responsibility. Currently there is an emerging consensus that a carbon tax should be applied globally to address the intractable problem of climate change. Since the problem relates to a global commons, the issue is how to apply the PPP globally yet equitably. This article brings in Caney’s proposal that as complementary to the PPP. The “ability to pay principle” (APP can take care of emissions of the past agreed by the Parties and current and future legitimate emissions of the disadvantaged countries and groups of people. He calls the latter poverty-sensitive PPP. While PPP is primarily a market principle, APP is a principle of justice and equity. That polluters should pay the social and environmental costs of their pollution reflects the most fundamental principles of justice and responsibility.

75 FR 9878 - Draft Principles and Standards Sections of the “Economic and Environmental Principles and...

Science.gov (United States)

2010-03-04

... COUNCIL ON ENVIRONMENTAL QUALITY Draft Principles and Standards Sections of the ``Economic and... the ``Economic and Environmental Principles and Guidelines for Water and Related Land Resources... may be accessed at the Internet addresses indicated: ``Economic and Environmental Principles and...

Two conceptions of legal principles

Directory of Open Access Journals (Sweden)

Spaić Bojan

2017-01-01

Full Text Available The paper discusses the classical understanding of legal principles as the most general norms of a legal order, confronting it with Dworkin's and Alexy's understanding of legal principles as prima facie, unconditional commands. The analysis shows that the common, classical conception brings into question the status of legal principles as norms, by disreguarding their usefulness in judicial reasoning, while, conversely, the latterhas significant import forlegal practice and consequently for legal dogmatics. It is argued that the heuristic fruitfulness of understanding principles as optimization commands thusbecomesapparent. When we understand the relation of priciples to the idea of proportionality, as thespecific mode of their application, which is different from the supsumtive mode of applying rules, the theory of legal principles advanced by Dworkin and Alexy appears therefore to be descriptively better than others, but not without its flaws.

Identifying the important factors in simulation models with many factors

NARCIS (Netherlands)

Bettonvil, B.; Kleijnen, J.P.C.

1994-01-01

Simulation models may have many parameters and input variables (together called factors), while only a few factors are really important (parsimony principle). For such models this paper presents an effective and efficient screening technique to identify and estimate those important factors. The

Global ethics and principlism.

Science.gov (United States)

Gordon, John-Stewart

2011-09-01

This article examines the special relation between common morality and particular moralities in the four-principles approach and its use for global ethics. It is argued that the special dialectical relation between common morality and particular moralities is the key to bridging the gap between ethical universalism and relativism. The four-principles approach is a good model for a global bioethics by virtue of its ability to mediate successfully between universal demands and cultural diversity. The principle of autonomy (i.e., the idea of individual informed consent), however, does need to be revised so as to make it compatible with alternatives such as family- or community-informed consent. The upshot is that the contribution of the four-principles approach to global ethics lies in the so-called dialectical process and its power to deal with cross-cultural issues against the background of universal demands by joining them together.

Assessing sustainable remediation frameworks using sustainability principles.

Science.gov (United States)

Ridsdale, D Reanne; Noble, Bram F

2016-12-15

The remediation industry has grown exponentially in recent decades. International organizations of practitioners and remediation experts have developed several frameworks for integrating sustainability into remediation projects; however, there has been limited attention to how sustainability is approached and operationalized in sustainable remediation frameworks and practices - or whether sustainability plays any meaningful role at all in sustainable remediation. This paper examines how sustainability is represented in remediation frameworks and the guidance provided for practical application. Seven broad sustainability principles and review criteria are proposed and applied to a sample of six international remediation frameworks. Not all review criteria were equally satisfied and none of the frameworks fully met all criteria; however, the best performing frameworks were those identified as sustainability remediation frameworks. Intra-generational equity was addressed by all frameworks. Integrating social, economic and biophysical components beyond triple-bottom-line indicators was explicitly addressed only by the sustainable remediation frameworks. No frameworks provided principle- or rule-based guidance for dealing with trade-offs in sustainability decisions. Copyright © 2016 Elsevier Ltd. All rights reserved.

The principle of general covariance and the principle of equivalence: two distinct concepts

International Nuclear Information System (INIS)

Fagundes, H.V.

It is shown how to construct a theory with general covariance but without the equivalence principle. Such a theory is in disagreement with experiment, but it serves to illustrate the independence of the former principle from the latter one [pt

Ethical principles in the work of nurse educator-A cross-sectional study.

Science.gov (United States)

Salminen, Leena; Stolt, Minna; Metsämäki, Riikka; Rinne, Jenni; Kasen, Anne; Leino-Kilpi, Helena

2016-01-01

The application of ethical principles within the teaching profession and nursing practice forms the core of the nurse educator's professional ethics. However, research focusing on the professional ethics of nurse educators is scarce. To describe ethical principles and issues relating to the work of nurse educators from the perspectives of both nurse educators themselves and nursing students. A descriptive study using cross-sectional data and content analysis. Nursing education program involving students from nine polytechnics in Finland. Nursing students (n=202) and nurse educators (n=342). Data were derived from an online survey, with two open-ended questions: Nursing students and nurse educators were asked to name the three main ethical principles that guide the work of nurse educators and also to describe ethical issues involved in the work. Students most often named professionalism, justice, and equality as the main ethical principles for a nurse educator. Nurse educators considered justice, equality, and honesty as the main ethical principles. The content analysis showed that professionalism and the relationship between educator and student were the key categories for ethical issues as perceived by nursing students. Nursing students most often identified inequality between the nurse educator and nursing student as the ethical issue faced by the nurse educator. Nursing students and nurse educators differed somewhat both in their views of the ethical principles guiding an educator's work and in the ethical issues arising in the work. Copyright © 2015 Elsevier Ltd. All rights reserved.

Limitations of Boltzmann's principle

International Nuclear Information System (INIS)

Lavenda, B.H.

1995-01-01

The usual form of Boltzmann's principle assures that maximum entropy, or entropy reduction, occurs with maximum probability, implying a unimodal distribution. Boltzmann's principle cannot be applied to nonunimodal distributions, like the arcsine law, because the entropy may be concave only over a limited portion of the interval. The method of subordination shows that the arcsine distribution corresponds to a process with a single degree of freedom, thereby confirming the invalidation of Boltzmann's principle. The fractalization of time leads to a new distribution in which arcsine and Cauchy distributions can coexist simultaneously for nonintegral degrees of freedom between √2 and 2

A Principle of Intentionality.

Science.gov (United States)

Turner, Charles K

2017-01-01

The mainstream theories and models of the physical sciences, including neuroscience, are all consistent with the principle of causality. Wholly causal explanations make sense of how things go, but are inherently value-neutral, providing no objective basis for true beliefs being better than false beliefs, nor for it being better to intend wisely than foolishly. Dennett (1987) makes a related point in calling the brain a syntactic (procedure-based) engine. He says that you cannot get to a semantic (meaning-based) engine from there. He suggests that folk psychology revolves around an intentional stance that is independent of the causal theories of the brain, and accounts for constructs such as meanings, agency, true belief, and wise desire. Dennett proposes that the intentional stance is so powerful that it can be developed into a valid intentional theory. This article expands Dennett's model into a principle of intentionality that revolves around the construct of objective wisdom. This principle provides a structure that can account for all mental processes, and for the scientific understanding of objective value. It is suggested that science can develop a far more complete worldview with a combination of the principles of causality and intentionality than would be possible with scientific theories that are consistent with the principle of causality alone.

PRISONERS' RIGHTS UNDER THE NIGERIAN LAW: LEGAL ...

African Journals Online (AJOL)

RAYAN_

have total assurance of enjoyment of the freedom of personal liberty under the law .... 11 National Human Rights Commission Nigeria Report of Prison Audit, 2009, p. 129. ..... Prisons Act also provides that the Director of the Nigerian Prison Service ..... punishment under any circumstances.95 This principle should, therefore,.

NOTES ON ARBITRABILITY UNDER ETHIOPIAN LAW Introduction ...

African Journals Online (AJOL)

eliasn

highlight the conceptual underpinnings of arbitrability in general and its treatment under Ethiopian ... not arbitrable under the law of the country where enforcement is sought.”3. ♧ .... general contract provisions concerning arbitration. When parties .... principle that “anything that is not prohibited is presumed to be permitted”,.

Principles and Procedures for Self-Access Materials

OpenAIRE

Brian Tomlinson

2010-01-01

Like all language learning materials, self-access materials need to be developed from principles driven by what is known about the needs and wants of the target users. In my view, there should be a specification of universal principles, delivery specific principles, and local principles before deciding what self-access materials to develop and how to develop them. Universal principles are principles of language acquisition and development (Tomlinson, 2007a) which are applicable to all learner...

A review of human factors principles for the design and implementation of medication safety alerts in clinical information systems

OpenAIRE

Phansalkar, Shobha; Edworthy, Judy; Hellier, Elizabeth; Seger, Diane L; Schedlbauer, Angela; Avery, Anthony J; Bates, David W

2010-01-01

The objective of this review is to describe the implementation of human factors principles for the design of alerts in clinical information systems. First, we conduct a review of alarm systems to identify human factors principles that are employed in the design and implementation of alerts. Second, we review the medical informatics literature to provide examples of the implementation of human factors principles in current clinical information systems using alerts to provide medication decisio...

Cooperation in wireless networks principles and applications : real egoistic behavior is to cooperate!

CERN Document Server

Fitzek, Frank HP

2006-01-01

Covers the underlying principles of cooperative techniques as well as several applications demonstrating the use of such techniques in practical systems. This book also summarizes the strength of cooperation for wireless communication systems, motivating the use of cooperative techniques.

The precautionary principle and chemicals regulation

DEFF Research Database (Denmark)

Løkke, Søren

2006-01-01

Background, Aim and Scope The paper investigates the development of the institutional basis of the present modes of chemicals regulation and management, with special attention to interrelations with the precautionary principle. Main Features: The paper elucidates on how the precautionary principle...... has been shaped in relation to chemicals regulation and management since Carson's Silent Spring (years before the principle was confirmed as a policy-principle in German and European legislation. Furthermore, it is examined how the precautionary principle interacted with the development of the present...... chemicals regulatory regime, in a complex interplay within the OECD and Member Countries. The present modes of precaution in the new EU chemical legislation – REACH – are investigated with respect to the precautionary principle, and tested against two contemporary problems; brominated flame retardants...

The Registration of Special Notarial Bonds under the Security by Means of Movable Property Act and the Publicity Principle: Lessons from Developments in Belgium

Directory of Open Access Journals (Sweden)

Lefa

2018-01-01

Full Text Available Many people do not own immovable property to offer as security but do have movable property which can be offered as security for the repayment of a debt. In today's world, where the costs of a motor car can exceed that of a house, the increasing value of movable things makes them popular and appropriate security objects. Under the common law pledge, delivery of the movable property from the pledgor (the debtor to the pledgee (the creditor has to take place in order for the pledgee to acquire a real security right in the property. Delivery of the property is aimed at ensuring compliance with the publicity principle. The principle of publicity entails that the existence of a real security must be known to the public. With the aim of promoting commerce, certain countries have taken the initiative in reforming their laws on pledge to allow the debtor to retain possession of the movable property that serves as security. Furthermore, technology has advanced to a level where national registration systems which can be accessed easily and at minimal cost can be established. The South African legislature enacted the Security by Means of Movable Property Act 57 of 1993 which makes provision for a pledge without possession. This Act deemed a duly registered notarial bond over specified movable property to have been delivered as if delivery had in fact taken place, thereby substituting the common law delivery requirement with registration in the Deeds Office. On 30 May 2013 the Belgian House of Representatives adopted a Belgian Pledge Act which allows for a non-possessory pledge on movable property subject to registration in a newly created public register called the Electronic Pledge Register. This article therefore examines the efficacy of the registration system of special notarial bonds in South African law and whether this form of registration complies with the publicity principle looking at the developments of a computerised registration system taking

Pedagogical Principles in Online Teaching

DEFF Research Database (Denmark)

Beckmann, Suzanne C.; Uth Thomsen, Thyra; von Wallpach, Sylvia

of the seven pedagogical principles that govern the teaching at our university. We also present a case study that illustrates how both opportunities and challenges were met in two “first-mover” fully online courses during Fall 2014. The experiences from this case study are discussed in terms of to what extent...... they met the pedagogical principles and observations unrelated to the pedagogical principle are shared....

General Principles for the welfare of animals in production systems: the underlying science and its application.

Science.gov (United States)

Fraser, David; Duncan, Ian J H; Edwards, Sandra A; Grandin, Temple; Gregory, Neville G; Guyonnet, Vincent; Hemsworth, Paul H; Huertas, Stella M; Huzzey, Juliana M; Mellor, David J; Mench, Joy A; Spinka, Marek; Whay, H Rebecca

2013-10-01

In 2012, the World Organisation for Animal Health adopted 10 'General Principles for the Welfare of Animals in Livestock Production Systems' to guide the development of animal welfare standards. The General Principles draw on half a century of scientific research relevant to animal welfare: (1) how genetic selection affects animal health, behaviour and temperament; (2) how the environment influences injuries and the transmission of diseases and parasites; (3) how the environment affects resting, movement and the performance of natural behaviour; (4) the management of groups to minimize conflict and allow positive social contact; (5) the effects of air quality, temperature and humidity on animal health and comfort; (6) ensuring access to feed and water suited to the animals' needs and adaptations; (7) prevention and control of diseases and parasites, with humane euthanasia if treatment is not feasible or recovery is unlikely; (8) prevention and management of pain; (9) creation of positive human-animal relationships; and (10) ensuring adequate skill and knowledge among animal handlers. Research directed at animal welfare, drawing on animal behaviour, stress physiology, veterinary epidemiology and other fields, complements more established fields of animal and veterinary science and helps to create a more comprehensive scientific basis for animal care and management. Copyright © 2013 Elsevier Ltd. All rights reserved.

Identifying Requirements for Effective Human-Automation Teamwork

Energy Technology Data Exchange (ETDEWEB)

Jeffrey C. Joe; John O' Hara; Heather D. Medema; Johanna H. Oxstrand

2014-06-01

Previous studies have shown that poorly designed human-automation collaboration, such as poorly designed communication protocols, often leads to problems for the human operators, such as: lack of vigilance, complacency, and loss of skills. These problems often lead to suboptimal system performance. To address this situation, a considerable amount of research has been conducted to improve human-automation collaboration and to make automation function better as a “team player.” Much of this research is based on an understanding of what it means to be a good team player from the perspective of a human team. However, the research is often based on a simplified view of human teams and teamwork. In this study, we sought to better understand the capabilities and limitations of automation from the standpoint of human teams. We first examined human teams to identify the principles for effective teamwork. We next reviewed the research on integrating automation agents and human agents into mixed agent teams to identify the limitations of automation agents to conform to teamwork principles. This research resulted in insights that can lead to more effective human-automation collaboration by enabling a more realistic set of requirements to be developed based on the strengths and limitations of all agents.

European and Czech principles of contract law

OpenAIRE

Horáková, Monika

2008-01-01

8 Summary European and Czech Principles of Contract Law This thesis is focused on principles of contract law. In the first instance, it explains the theoretical conception of principles of law and adverts to their status in the Czech legal system. The second Chapter of the thesis dissertates about basic principles of the Czech private law starting with the principle of freedom of contract, ends with the principles of good faith and fair dealing. The main part of the thesis deals with the Euro...

Accountability Principles for Research Organizations | IDRC ...

International Development Research Centre (IDRC) Digital Library (Canada)

2011-10-28

Oct 28, 2011 ... Accountability Principles of Research Organisations provides a ... good practices and principles for policy-oriented research organizations working in developing countries. ... Image. IDRC. Accountability Principles of Research Organisations ... The Association for Progressive Communications Women's ...

Is the Precautionary Principle Really Incoherent?

Science.gov (United States)

Boyer-Kassem, Thomas

2017-11-01

The Precautionary Principle has been an increasingly important principle in international treaties since the 1980s. Through varying formulations, it states that when an activity can lead to a catastrophe for human health or the environment, measures should be taken to prevent it even if the cause-and-effect relationship is not fully established scientifically. The Precautionary Principle has been critically discussed from many sides. This article concentrates on a theoretical argument by Peterson (2006) according to which the Precautionary Principle is incoherent with other desiderata of rational decision making, and thus cannot be used as a decision rule that selects an action among several ones. I claim here that Peterson's argument fails to establish the incoherence of the Precautionary Principle, by attacking three of its premises. I argue (i) that Peterson's treatment of uncertainties lacks generality, (ii) that his Archimedian condition is problematic for incommensurability reasons, and (iii) that his explication of the Precautionary Principle is not adequate. This leads me to conjecture that the Precautionary Principle can be envisaged as a coherent decision rule, again. © 2017 Society for Risk Analysis.

Operating principle of Soft Open Points for electrical distribution network operation

International Nuclear Information System (INIS)

Cao, Wanyu; Wu, Jianzhong; Jenkins, Nick; Wang, Chengshan; Green, Timothy

2016-01-01

Highlights: • Two control modes were developed for a B2B VSCs based SOP. • The SOP operating principle was investigated under various network conditions. • The performance of the SOP using two control modes was analyzed. - Abstract: Soft Open Points (SOPs) are power electronic devices installed in place of normally-open points in electrical power distribution networks. They are able to provide active power flow control, reactive power compensation and voltage regulation under normal network operating conditions, as well as fast fault isolation and supply restoration under abnormal conditions. Two control modes were developed for the operation of an SOP, using back-to-back voltage-source converters (VSCs). A power flow control mode with current control provides independent control of real and reactive power. A supply restoration mode with a voltage controller enables power supply to isolated loads due to network faults. The operating principle of the back-to-back VSCs based SOP was investigated under both normal and abnormal network operating conditions. Studies on a two-feeder medium-voltage distribution network showed the performance of the SOP under different network-operating conditions: normal, during a fault and post-fault supply restoration. During the change of network operating conditions, a mode switch method based on the phase locked loop controller was used to achieve the transitions between the two control modes. Hard transitions by a direct mode switching were noticed unfavourable, but seamless transitions were obtained by deploying a soft cold load pickup and voltage synchronization process.

THE EQUALITY PRINCIPLE REQUIREMENTS

Directory of Open Access Journals (Sweden)

CLAUDIA ANDRIŢOI

2013-05-01

Full Text Available The problem premises and the objectives followed: the idea of inserting the equality principle between the freedom and the justice principles is manifested in positive law in two stages, as a general idea of all judicial norms and as requirement of the owner of a subjective right of the applicants of an objective law. Equality in face of the law and of public authorities can not involve the idea of standardization, of uniformity, of enlisting of all citizens under the mark of the same judicial regime, regardless of their natural or socio-professional situation. Through the Beijing Platform and the position documents of the European Commission we have defined the integrative approach of equality as representing an active and visible integration of the gender perspective in all sectors and at all levels. The research methods used are: the conceptualist method, the logical method and the intuitive method necessary as means of reasoning in order to argue our demonstration. We have to underline the fact that the system analysis of the research methods of the judicial phenomenon doesn’t agree with “value ranking”, because one value cannot be generalized in rapport to another. At the same time, we must fight against a methodological extremism. The final purpose of this study is represented by the reaching of the perfecting/excellence stage by all individuals through the promotion of equality and freedom. This supposes the fact that the existence of a non-discrimination favourable frame (fairness represents a means and a condition of self-determination, and the state of perfection/excellency is a result of this self-determination, the condition necessary for the obtaining of this nondiscrimination frame for all of us and in conditions of freedom for all individuals, represents the same condition that promotes the state of perfection/excellency. In conclusion we may state the fact that the equality principle represents a true catalyst of the

Fermat principle for a nonstationary medium.

Science.gov (United States)

Voronovich, A G; Godin, O A

2003-07-25

One possible formulation of a variational principle of the Fermat type for systems with time-dependent parameters is suggested. In a stationary case, it reduces to the Mopertui-Lagrange least-action principle. A class of Hamiltonians (dispersion relations) is indicated, for which the variational principle reduces to the Fermat principle in a general nonstationary case. Hamiltonians that are homogeneous functions of momenta are in this category. For the important case of nondispersive waves (corresponding to Hamiltonians being homogeneous function of momenta order 1) the Fermat principle fully determines the geometry of the rays. Equations relating the variation of signal frequency with the rate of change of propagation time are established.

PRINCIPLE OF THE ELECTRONIC EDUCATIONAL ENVIRONMENT SECURITY IN THE PROFESSIONAL TRAINING OF UNIVERSITY STUDENTS

Directory of Open Access Journals (Sweden)

Valery G. Tylets

2017-12-01

Full Text Available The article considers the problem of professional training of students in e-learning environment in accordance with the principle of security. The authors offer the essay technology of multiple difficulty levels. In the article the description of each level of technology proves its conformity to the positions of principle of security. The main methods of measurement performance were made by expert assessment and subjective scaling. The analysis of results of approbation of essay technology of multiple difficulty levels in the experimental sample showed an increase of objective and subjective indicators. Positive methodological and personal effects of the introduction of technology into the process of university education were identified, corresponding to the positions of principle of security. Methodical recommendations of application of technology were formulated.

Who believes in the Taylor Principle?

DEFF Research Database (Denmark)

Stadtmann, Georg; Pierdzioch; Rülke

2012-01-01

The Livingston survey data are used to investigate whether economists’ forecasts are consistent with the Taylor principle. Consistency with the Taylor principle is strong for academics and Federal Reserve economists, and less strong for private-sector economists.......The Livingston survey data are used to investigate whether economists’ forecasts are consistent with the Taylor principle. Consistency with the Taylor principle is strong for academics and Federal Reserve economists, and less strong for private-sector economists....

Principles governing heart failure therapy re-examined relative to standard evidence-based medicine-driven guidelines.

Science.gov (United States)

Tan, Lip-Bun; Chinnappa, Shanmugakumar; Tan, David K H; Hall, Alistair S

2011-09-01

Although all aspects of clinical work nowadays are modified by the pervading influence of evidence-based medicine (EBM) and multiplicative guidelines, not many clinicians realize that the underlying premise of EBM-driven guidelines is a particular strain of consequentialist ideology. Subservience to this ideology has transformed modern medical practice, but there is a real risk of distorting good medical practice, of belittling clinical judgement, of disempowering clinicians, and subjecting patients to skewed medical reality and treatment options. With so many heart failure (HF) guidelines issued by various august bodies, it is therefore timely to reappraise principles governing modern HF therapy with a fresh examination of the hierarchy of medical imperatives, the role of alternatives to consequentialism including deontological principles in HF therapy. In addition, other ideology worth re-examining, aside from EBM, are the principle of appropriate definition of HF underlying therapeutic goals and the principle of prioritizing objectives of HF therapy. Even within standard EBM, there are many questions to reconsider: about what types of evidence are admissible, different interpretations of available evidence, emphasizing patient-centered outcome measures instead of randomized controlled trials quantifiable therapeutic outcomes, how to prescribe drugs for prognostic versus symptomatic benefits, and how to deliver HF therapy based on pathophysiological features through mechanistic considerations and not just confined to randomized controlled trials or meta-analytical statistical imperatives. Through re-examination of these fundamental principles of HF therapy, it is hoped that clinicians will be empowered to manage HF patients more holistically and better deliver HF therapies in the best interest of each individual patient.

The principle of equivalence

International Nuclear Information System (INIS)

Unnikrishnan, C.S.

1994-01-01

Principle of equivalence was the fundamental guiding principle in the formulation of the general theory of relativity. What are its key elements? What are the empirical observations which establish it? What is its relevance to some new experiments? These questions are discussed in this article. (author). 11 refs., 5 figs

Sensitivity to the Sampling Process Emerges From the Principle of Efficiency.

Science.gov (United States)

Jara-Ettinger, Julian; Sun, Felix; Schulz, Laura; Tenenbaum, Joshua B

2018-05-01

Humans can seamlessly infer other people's preferences, based on what they do. Broadly, two types of accounts have been proposed to explain different aspects of this ability. The first account focuses on spatial information: Agents' efficient navigation in space reveals what they like. The second account focuses on statistical information: Uncommon choices reveal stronger preferences. Together, these two lines of research suggest that we have two distinct capacities for inferring preferences. Here we propose that this is not the case, and that spatial-based and statistical-based preference inferences can be explained by the assumption that agents are efficient alone. We show that people's sensitivity to spatial and statistical information when they infer preferences is best predicted by a computational model of the principle of efficiency, and that this model outperforms dual-system models, even when the latter are fit to participant judgments. Our results suggest that, as adults, a unified understanding of agency under the principle of efficiency underlies our ability to infer preferences. Copyright © 2018 Cognitive Science Society, Inc.

Cultured Cortical Neurons Can Perform Blind Source Separation According to the Free-Energy Principle

Science.gov (United States)

Isomura, Takuya; Kotani, Kiyoshi; Jimbo, Yasuhiko

2015-01-01

Blind source separation is the computation underlying the cocktail party effect––a partygoer can distinguish a particular talker’s voice from the ambient noise. Early studies indicated that the brain might use blind source separation as a signal processing strategy for sensory perception and numerous mathematical models have been proposed; however, it remains unclear how the neural networks extract particular sources from a complex mixture of inputs. We discovered that neurons in cultures of dissociated rat cortical cells could learn to represent particular sources while filtering out other signals. Specifically, the distinct classes of neurons in the culture learned to respond to the distinct sources after repeating training stimulation. Moreover, the neural network structures changed to reduce free energy, as predicted by the free-energy principle, a candidate unified theory of learning and memory, and by Jaynes’ principle of maximum entropy. This implicit learning can only be explained by some form of Hebbian plasticity. These results are the first in vitro (as opposed to in silico) demonstration of neural networks performing blind source separation, and the first formal demonstration of neuronal self-organization under the free energy principle. PMID:26690814

Cultured Cortical Neurons Can Perform Blind Source Separation According to the Free-Energy Principle.

Directory of Open Access Journals (Sweden)

Takuya Isomura

2015-12-01

Full Text Available Blind source separation is the computation underlying the cocktail party effect--a partygoer can distinguish a particular talker's voice from the ambient noise. Early studies indicated that the brain might use blind source separation as a signal processing strategy for sensory perception and numerous mathematical models have been proposed; however, it remains unclear how the neural networks extract particular sources from a complex mixture of inputs. We discovered that neurons in cultures of dissociated rat cortical cells could learn to represent particular sources while filtering out other signals. Specifically, the distinct classes of neurons in the culture learned to respond to the distinct sources after repeating training stimulation. Moreover, the neural network structures changed to reduce free energy, as predicted by the free-energy principle, a candidate unified theory of learning and memory, and by Jaynes' principle of maximum entropy. This implicit learning can only be explained by some form of Hebbian plasticity. These results are the first in vitro (as opposed to in silico demonstration of neural networks performing blind source separation, and the first formal demonstration of neuronal self-organization under the free energy principle.

Human Dignity – Constitutional Principle of Fundamental Human Rights

Directory of Open Access Journals (Sweden)

Lucian Pop

2011-07-01

Full Text Available As a constitutional principle of the human rights, the human dignity is a supreme value, a norm and a right, thus that the reconfiguration of protection standards of fundamental human rights is made by cohesion of the legal, social and moral dimensions of human dignity. With this article, the author argues that legal meaning, social meaning and moral meaning of human dignity, are centerpiece of protection of freedom under law.

Global Harmonic Current Rejection of Nonlinear Backstepping Control with Multivariable Adaptive Internal Model Principle for Grid-Connected Inverter under Distorted Grid Voltage

Directory of Open Access Journals (Sweden)

Yang Yu

2013-01-01

Full Text Available Based on a brief review on current harmonics generation mechanism for grid-connected inverter under distorted grid voltage, the harmonic disturbances and uncertain items are immersed into the original state-space differential equation of grid-connected inverter. A new algorithm of global current harmonic rejection based on nonlinear backstepping control with multivariable internal model principle is proposed for grid-connected inverter with exogenous disturbances and uncertainties. A type of multivariable internal model for a class of nonlinear harmonic disturbances is constructed. Based on application of backstepping control law of the nominal system, a multivariable adaptive state feedback controller combined with multivariable internal model and adaptive control law is designed to guarantee the closed-loop system globally uniformly bounded, which is proved by a constructed Lyapunov function. The presented algorithm extends rejection of nonlinear single-input systems to multivariable globally defined normal form, the correctness and effectiveness of which are verified by the simulation results.

Recommendations for Mass Spectrometry Data Quality Metrics for Open Access Data (Corollary to the Amsterdam Principles)

DEFF Research Database (Denmark)

Kinsinger, Christopher R.; Apffel, James; Baker, Mark

2011-01-01

and deployment of methods for measuring and documenting data quality metrics. On September 18, 2010, the United States National Cancer Institute convened the "International Workshop on Proteomic Data Quality Metrics" in Sydney, Australia, to identify and address issues facing the development and use......Policies supporting the rapid and open sharing of proteomic data are being implemented by the leading journals in the field. The proteomics community is taking steps to ensure that data are made publicly accessible and are of high quality, a challenging task that requires the development...... of such methods for open access proteomics data. The stakeholders at the workshop enumerated the key principles underlying a framework for data quality assessment in mass spectrometry data that will meet the needs of the research community, journals, funding agencies, and data repositories. Attendees discussed...

Recommendations for Mass Spectrometry Data Quality Metrics for Open Access Data (Corollary to the Amsterdam Principles)

DEFF Research Database (Denmark)

Kinsinger, Christopher R.; Apffel, James; Baker, Mark

2012-01-01

and deployment of methods for measuring and documenting data quality metrics. On September 18, 2010, the United States National Cancer Institute convened the "International Workshop on Proteomic Data Quality Metrics" in Sydney, Australia, to identify and address issues facing the development and use......Policies supporting the rapid and open sharing of proteomic data are being implemented by the leading journals in the field. The proteomics community is taking steps to ensure that data are made publicly accessible and are of high quality, a challenging task that requires the development...... of such methods for open access proteomics data. The stakeholders at the workshop enumerated the key principles underlying a framework for data quality assessment in mass spectrometry data that will meet the needs of the research community, journals, funding agencies, and data repositories. Attendees discussed...

Ethical principles of scientific communication

Directory of Open Access Journals (Sweden)

Baranov G. V.

2017-03-01

Full Text Available the article presents the principles of ethical management of scientific communication. The author approves the priority of ethical principle of social responsibility of the scientist.

The Dutch premium principle

NARCIS (Netherlands)

van Heerwaarden, A.E.; Kaas, R.

1992-01-01

A premium principle is derived, in which the loading for a risk is the reinsurance loading for an excess-of-loss cover. It is shown that the principle is well-behaved in the sense that it results in larger premiums for risks that are larger in stop-loss order or in stochastic dominance.

A new electrophoretic focusing principle: focusing of nonamphoteric weak ionogenic analytes using inverse electromigration dispersion profiles.

Science.gov (United States)

Gebauer, Petr; Malá, Zdena; Bocek, Petr

2010-03-01

This contribution introduces a new separation principle in CE which offers focusing of weak nonamphoteric ionogenic species and their inherent transport to the detector. The prerequisite condition for application of this principle is the existence of an inverse electromigration dispersion profile, i.e. a profile where pH is decreasing toward the anode or cathode for focusing of anionic or cationic weak analytes, respectively. The theory presented defines the principal conditions under which an analyte is focused on a profile of this type. Since electromigration dispersion profiles are migrating ones, the new principle offers inherent transport of focused analytes into the detection cell. The focusing principle described utilizes a mechanism different from both CZE (where separation is based on the difference in mobilities) and IEF (where separation is based on difference in pI), and hence, offers another separation dimension in CE. The new principle and its theory presented here are supplemented by convincing experiments as their proof.

7 CFR 3430.31 - Guiding principles.

Science.gov (United States)

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Guiding principles. 3430.31 Section 3430.31 Agriculture Regulations of the Department of Agriculture (Continued) COOPERATIVE STATE RESEARCH, EDUCATION... § 3430.31 Guiding principles. The guiding principle for Federal assistance application review and...

Similarity principles for equipment qualification by experience

International Nuclear Information System (INIS)

Kana, D.D.; Pomerening, D.J.

1988-07-01

A methodology is developed for seismic qualification of nuclear plant equipment by applying similarity principles to existing experience data. Experience data are available from previous qualifications by analysis or testing, or from actual earthquake events. Similarity principles are defined in terms of excitation, equipment physical characteristics, and equipment response. Physical similarity is further defined in terms of a critical transfer function for response at a location on a primary structure, whose response can be assumed directly related to ultimate fragility of the item under elevated levels of excitation. Procedures are developed for combining experience data into composite specifications for qualification of equipment that can be shown to be physically similar to the reference equipment. Other procedures are developed for extending qualifications beyond the original specifications under certain conditions. Some examples for application of the procedures and verification of them are given for certain cases that can be approximated by a two degree of freedom simple primary/secondary system. Other examples are based on use of actual test data available from previous qualifications. Relationships of the developments with other previously-published methods are discussed. The developments are intended to elaborate on the rather broad revised guidelines developed by the IEEE 344 Standards Committee for equipment qualification in new nuclear plants. However, the results also contribute to filling a gap that exists between the IEEE 344 methodology and that previously developed by the Seismic Qualification Utilities Group. The relationship of the results to safety margin methodology is also discussed. (author)

Liberal egalitarianism and the harm principle

OpenAIRE

Lombardi, Michele; Veneziani, Roberto

2009-01-01

This paper analyses Rawls's celebrated difference principle, and its lexicographic extension, in societies with a finite and an infinite number of agents. A unified framework of analysis is set up, which allows one to characterise Rawlsian egalitarian principles by means of a weaker version of a new axiom - the Harm Principle - recently proposed by marven09. This is quite surprising, because the Harm principle is meant to capture a liberal requirement of noninterference and it incorporates no...

Microsurgical principles and postoperative adhesions: lessons from the past.

Science.gov (United States)

Gomel, Victor; Koninckx, Philippe R

2016-10-01

"Microsurgery" is a set of principles developed to improve fertility surgery outcomes. These principles were developed progressively based on common sense and available evidence, under control of clinical feedback obtained with the use of second-look laparoscopy. Fertility outcome was the end point; significant improvement in fertility rates validated the concept clinically. Postoperative adhesion formation being a major cause of failure in fertility surgery, the concept of microsurgery predominantly addresses prevention of postoperative adhesions. In this concept, magnification with a microscope or laparoscope plays a minor role as technical facilitator. Not surprisingly, the principles to prevent adhesion formation are strikingly similar to our actual understanding: gentle tissue handling, avoiding desiccation, irrigation at room temperature, shielding abdominal contents from ambient air, meticulous hemostasis and lavage, avoiding foreign body contamination and infection, administration of dexamethasone postoperatively, and even the concept of keeping denuded areas separated by temporary adnexal or ovarian suspension. The actual concepts of peritoneal conditioning during surgery and use of dexamethasone and a barrier at the end of surgery thus confirm without exception the tenets of microsurgery. Although recent research helped to clarify the pathophysiology of adhesion formation, refined its prevention and the relative importance of each factor, the clinical end point of improvement of fertility rates remains demonstrated for only the microsurgical tenets as a whole. In conclusion, the principles of microsurgery remain fully valid as the cornerstones of reproductive microsurgery, whether performed by means of open access or laparoscopy. Copyright © 2016 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

Addressing vaccine hesitancy: The potential value of commercial and social marketing principles and practices.

Science.gov (United States)

Nowak, Glen J; Gellin, Bruce G; MacDonald, Noni E; Butler, Robb

2015-08-14

Many countries and communities are dealing with groups and growing numbers of individuals who are delaying or refusing recommended vaccinations for themselves or their children. This has created a need for immunization programs to find approaches and strategies to address vaccine hesitancy. An important source of useful approaches and strategies is found in the frameworks, practices, and principles used by commercial and social marketers, many of which have been used by immunization programs. This review examines how social and commercial marketing principles and practices can be used to help address vaccine hesitancy. It provides an introduction to key marketing and social marketing concepts, identifies some of the major challenges to applying commercial and social marketing approaches to immunization programs, illustrates how immunization advocates and programs can use marketing and social marketing approaches to address vaccine hesitancy, and identifies some of the lessons that commercial and non-immunization sectors have learned that may have relevance for immunization. While the use of commercial and social marketing practices and principles does not guarantee success, the evidence, lessons learned, and applications to date indicate that they have considerable value in fostering vaccine acceptance. Copyright © 2015. Published by Elsevier Ltd.

How Many Principles for Public Health Ethics?

OpenAIRE

Coughlin, Steven S.

2008-01-01

General moral (ethical) principles play a prominent role in certain methods of moral reasoning and ethical decision-making in bioethics and public health. Examples include the principles of respect for autonomy, beneficence, nonmaleficence, and justice. Some accounts of ethics in public health have pointed to additional principles related to social and environmental concerns, such as the precautionary principle and principles of solidarity or social cohesion. This article provides an overview...

Pediatric disaster response in developed countries: ten guiding principles.

Science.gov (United States)

Brandenburg, Mark A; Arneson, Wendy L

2007-01-01

Mass casualty incidents and large-scale disasters involving children are likely to overwhelm a regional disaster response system. Children have unique vulnerabilities that require special considerations when developing pediatric response systems. Although medical and trauma strategies exist for the evaluation and treatment of children on a daily basis, the application of these strategies under conditions of resource-constrained triage and treatment have rarely been evaluated. A recent report, however, by the Institute of Medicine did conclude that on a day-to-day basis the U.S. healthcare system does not adequately provide emergency medical services for children. The variability, scale, and uncertainty of disasters call for a set of guiding principles rather than rigid protocols when developing pediatric response plans. The authors propose the following guiding principles in addressing the well-recognized, unique vulnerabilities of children: (1) terrorism prevention and preparedness, (2) all-hazards preparedness, (3) postdisaster disease and injury prevention, (4) nutrition and hydration, (5) equipment and supplies, (6) pharmacology, (7) mental health, (8) identification and reunification of displaced children, (9) day care and school, and (10) perinatology. It is hoped that the 10 guiding principles discussed in this article will serve as a basic framework for developing pediatric response plans and teams in developed countries.

Assessing participants' perceptions on group-based principles for action in community-based health enhancing physical activity programmes: The APEF tool.

Science.gov (United States)

Herens, Marion; Wagemakers, Annemarie

2017-12-01

In community-based health enhancing physical activity (CBHEPA) programmes, group-based principles for action such as active participation, enjoyment, and fostering group processes are widely advocated. However, not much is known about participants' perceptions of these principles as there are no assessment tools available. Therefore, this article describes the development of the APEF (Active Participation, Enjoyment, and Fostering group processes) tool and reports on its implementation in a Dutch CBHEPA programme. Indicators for the principles have been identified from literature research, interviews with professionals, and secondary analysis of three group interviews with 11 practitioners. To address the identified indicators, the APEF tool was developed, pretested, and used in 10 focus groups with 76 participants. The APEF tool consists of eight statements about group-based principles for action, on which CBHEPA participants vote, followed by in-depth discussion. The voting procedure engages participants. Spider diagrams visualise participants' perceptions of group-based principles. The APEF tool addresses the challenge of relating group level outcomes to individual outcomes such as physical activity behaviour. The tool facilitates as well as evaluates group-based principles for action, it stimulates dialogue and is culturally sensitive, but it needs strong facilitating skills to manage group dynamics. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

Viscous Regularization of the Euler Equations and Entropy Principles

KAUST Repository

Guermond, Jean-Luc

2014-03-11

This paper investigates a general class of viscous regularizations of the compressible Euler equations. A unique regularization is identified that is compatible with all the generalized entropies, à la [Harten et al., SIAM J. Numer. Anal., 35 (1998), pp. 2117-2127], and satisfies the minimum entropy principle. A connection with a recently proposed phenomenological model by [H. Brenner, Phys. A, 370 (2006), pp. 190-224] is made. © 2014 Society for Industrial and Applied Mathematics.

Full Kinetics from First Principles of the Chlorine Evolution Reaction over a RuO2 (110) Model Electrode.