WorldWideScience

Sample records for identify sites suitable

  1. Identifying suitable sites for Florida panther reintroduction

    Science.gov (United States)

    Thatcher, Cindy A.; van Manen, Frank T.; Clark, Joseph D.

    2006-01-01

    A major objective of the 1995 Florida Panther (Puma concolor cory) Recovery Plan is the establishment of 2 additional panther populations within the historic range. Our goal was to identify prospective sites for Florida panther reintroduction within the historic range based on quantitative landscape assessments. First, we delineated 86 panther home ranges using telemetry data collected from 1981 to 2001 in south Florida to develop a Mahalanobis distance (D2) habitat model, using 4 anthropogenic variables and 3 landscape variables mapped at a 500-m resolution. From that analysis, we identified 9 potential reintroduction sites of sufficient size to support a panther population. We then developed a similar D2 model at a higher spatial resolution to quantify the area of favorable panther habitat at each site. To address potential for the population to expand, we calculated the amount of favorable habitat adjacent to each prospective reintroduction site within a range of dispersal distances of female panthers. We then added those totals to the contiguous patches to estimate the total amount of effective panther habitat at each site. Finally, we developed an expert-assisted model to rank and incorporate potentially important habitat variables that were not appropriate for our empirical analysis (e.g., area of public lands, livestock density). Anthropogenic factors heavily influenced both the landscape and the expert-assisted models. Of the 9 areas we identified, the Okefenokee National Wildlife Refuge, Ozark National Forest, and Felsenthal National Wildlife Refuge regions had the highest combination of effective habitat area and expert opinion scores. Sensitivity analyses indicated that variability among key model parameters did not affect the high ranking of those sites. Those sites should be considered as starting points for the field evaluation of potential reintroduction sites.

  2. Identifying suitable piercement salt domes for nuclear waste storage sites

    International Nuclear Information System (INIS)

    Kehle, R.; e.

    1980-08-01

    Piercement salt domes of the northern interior salt basins of the Gulf of Mexico are being considered as permanent storage sites for both nuclear and chemically toxic wastes. The suitable domes are stable and inactive, having reached their final evolutionary configuration at least 30 million years ago. They are buried to depths far below the level to which erosion will penetrate during the prescribed storage period and are not subject to possible future reactivation. The salt cores of these domes are themselves impermeable, permitting neither the entry nor exit of ground water or other unwanted materials. In part, a stable dome may be recognized by its present geometric configuration, but conclusive proof depends on establishing its evolutionary state. The evolutionary state of a dome is obtained by reconstructing the growth history of the dome as revealed by the configuration of sedimentary strata in a large area (commonly 3,000 square miles or more) surrounding the dome. A high quality, multifold CDP reflection seismic profile across a candidate dome will provide much of the necessary information when integrated with available subsurface control. Additional seismic profiles may be required to confirm an apparent configuration of the surrounding strata and an interpreted evolutionary history. High frequency seismic data collected in the near vicinity of a dome are also needed as a supplement to the CDP data to permit accurate depiction of the configuration of shallow strata. Such data must be tied to shallow drill hole control to confirm the geologic age at which dome growth ceased. If it is determined that a dome reached a terminal configuration many millions of years ago, such a dome is incapable of reactivation and thus constitutes a stable storage site for nuclear wastes

  3. Rigorous Screening Technology for Identifying Suitable CO2 Storage Sites II

    Energy Technology Data Exchange (ETDEWEB)

    George J. Koperna Jr.; Vello A. Kuuskraa; David E. Riestenberg; Aiysha Sultana; Tyler Van Leeuwen

    2009-06-01

    This report serves as the final technical report and users manual for the 'Rigorous Screening Technology for Identifying Suitable CO2 Storage Sites II SBIR project. Advanced Resources International has developed a screening tool by which users can technically screen, assess the storage capacity and quantify the costs of CO2 storage in four types of CO2 storage reservoirs. These include CO2-enhanced oil recovery reservoirs, depleted oil and gas fields (non-enhanced oil recovery candidates), deep coal seems that are amenable to CO2-enhanced methane recovery, and saline reservoirs. The screening function assessed whether the reservoir could likely serve as a safe, long-term CO2 storage reservoir. The storage capacity assessment uses rigorous reservoir simulation models to determine the timing, ultimate storage capacity, and potential for enhanced hydrocarbon recovery. Finally, the economic assessment function determines both the field-level and pipeline (transportation) costs for CO2 sequestration in a given reservoir. The screening tool has been peer reviewed at an Electrical Power Research Institute (EPRI) technical meeting in March 2009. A number of useful observations and recommendations emerged from the Workshop on the costs of CO2 transport and storage that could be readily incorporated into a commercial version of the Screening Tool in a Phase III SBIR.

  4. Preliminary Site Suitability Evaluation

    International Nuclear Information System (INIS)

    J. L. King

    2001-01-01

    Commercial electric power generation, nuclear weapons production, the operation of naval reactors, and research and development activities produce spent nuclear fuel and high-level radioactive waste. Spent nuclear fuel and high-level radioactive waste have been accumulating at commercial reactor sites and storage facilities across the country since 1957. Spent nuclear fuel and high-level radioactive waste have been accumulating at sites now managed by U.S. Department of Energy (DOE) since the mid-1940s. The DOE has the statutory obligation to dispose of these wastes. The U.S. has studied methods for the safe storage and disposal of radioactive waste for more than 40 years. Many organizations and government agencies have participated in these studies. In the 1950s, the U.S. Atomic Energy Commission requested the National Academy of Sciences to evaluate options for land disposal of radioactive waste. The U.S. Atomic Energy Commission and its successor agencies, the Energy Research and Development Administration and the DOE, continued to analyze radioactive waste management options throughout the 1960s and 1970s. In 1979, an Interagency Review Group that included representatives of 14 federal government entities provided findings and recommendations to the President. After analyzing a range of options, disposal in a geologic repository emerged as the preferred long-term environmental solution. This consensus is reflected in the Nuclear Waste Policy Act of 1982 (NWPA). The NWPA and related statutes established the framework for addressing the issues of radioactive waste disposal and designated the roles and responsibilities of the federal government and the owners and generators of the waste

  5. Characteristics and suitability of waste dump sites in Owerri, Nigeria ...

    African Journals Online (AJOL)

    A five point criteria screening of the three major waste dumpsites in Owerri Municipality was identified, and a ranking procedure adopted to determine the suitability or otherwise of the dumpsites. The sites were screened and ranked hydro-geologically and geo-technically in order of suitable, moderately suitable, and not ...

  6. Additional media studies for site suitability criteria

    International Nuclear Information System (INIS)

    Donich, T.R.; Kaufman, A.M.; Sauter, G.D.; Steinborn, T.L.; Towse, D.F.

    1978-01-01

    Site suitability studies have been made previously at LLL on bedded salt and shale. In the present study domed salt, basalt, and crystalline rock are compared with bedded salt and shale and with each other as possible repositories. The level of effort required to develop models for these media that are similar in quality to those available for bedded salt and shale is evaluated. The effort necessary to develop data bases on the physical and chemical properties comparable to that available for bedded salt and shale is also estimated. Each medium is evaluated as a suitable repository environment. The funding necessary for model and data base development is estimated

  7. Perspective in site-suitability modelling

    International Nuclear Information System (INIS)

    Chartier, M.

    1989-01-01

    The Steering Committee for Nuclear Energy of the OECD-Nuclear Energy Agency decided in April 1981 to set up a Co-ordinated Research and Environmental Surveillance Programme relevant to sea disposal of radioactive waste (CRESP) with the objective of reinforcing the scientific basis of future assessments of the continued suitability of the North-East Atlantic site to be made under the NEA Multilateral Consultation and Surveillance Mechanism. A major component of the initial CRESP plan was the development of a site-specific model to predict radionuclide transfer rates and patterns in the marine environment. A new general approach to the design of such a site-specific model is discussed.Although this approach originates partly from methodologies presented in GESAMP partly from an approach put forward within the NEA Seabed Working Group/Geochemical and Physical Oceanography Task Group and partly from methods previously agreed by the CRESP Modelling Task Group, the modelling philosophy developed in the text expressed the personal viewpoint of the author. This text aims to state the present methods of modelling the marine transfer of radionuclides and to anticipate modelling strategies which may be adopted in the future (in France for example), but it does not necessarily meet present NEA viewpoints and the philosophy of other CRESP participating countries

  8. Land suitability maps for waste disposal siting

    International Nuclear Information System (INIS)

    Hrasna, M.

    1996-01-01

    The suitability of geoenvironment for waste disposal depends mainly on its stability and on the danger of groundwater pollution. Besides them, on the land suitability maps for the given purpose also those factors of the factors of the geoenvironment and the landscape should be taken into account, which enable another way of the land use, such as mineral resources, water resources, fertile soils, nature reserves, etc. On the base of the relevant factors influence evaluation - suitable, moderately suitable and unsuitable territorial units are delimited on the maps. The different way of various scale maps compilation is applied, taken into account their different representing feasibilities. (authors)

  9. Selection of suitable sites for NPP in Slovenia (stage 3)

    International Nuclear Information System (INIS)

    Grgic, M.; Fabjan, L.; Premru, U.

    1977-01-01

    Selection of suitable sites for nuclear power plants in Slovenia is considered. This includes the studies of available data on regional and local characteristics specified in general site suitability criteria for NPP. The most suitable selected sites will be included into land use urbanistic planning of Slovenia

  10. Report of early site suitability evaluation of the potential repository site at Yucca Mountain, Nevada

    International Nuclear Information System (INIS)

    Younker, J.L.; Andrews, W.B.; Fasano, G.A.; Herrington, C.C.; Mattson, S.R.; Murray, R.C.; Ballou, L.B.; Revelli, M.A.; Ducharme, A.R.; Shephard, L.E.; Dudley, W.W.; Hoxie, D.T.; Herbst, R.J.; Patera, E.A.; Judd, B.R.; Docka, J.A.; Rickertsen, L.D.

    1992-01-01

    This study evaluated the technical suitability of Yucca Mountain, Nevada, as a potential site for a mined geologic repository for the permanent disposal of radioactive waste. The evaluation was conducted primarily to determine early in the site characterization program if there are any features or conditions at the site that indicate it is unsuitable for repository development. A secondary purpose was to determine the status of knowledge in the major technical areas that affect the suitability of the site. This early site suitability evaluation (ESSE) was conducted by a team of technical personnel at the request of the Associate Director of the US Department of Energy (DOE) Office of Geologic Disposal, a unit within the DOE's Office of Civilian Radioactive Waste Management. The Yucca Mountain site has been the subject of such evaluations for over a decade. In 1983, the site was evaluated as part of a screening process to identify potentially acceptable sites. The site was evaluated in greater detail and found suitable for site characterization as part of the Environmental Assessment (EA) (DOE, 1986) required by the Nuclear Waste Policy Act of 1982 (NWPA). Additional site data were compiled during the preparation of the Site Characterization Plan (SCP) (DOE, 1988a). This early site suitability evaluation has considered information that was used in preparing both-documents, along with recent information obtained since the EA and SCP were published. This body of information is referred to in this report as ''current information'' or ''available evidence.''

  11. Land use suitability screening for power plant sites in Maryland

    International Nuclear Information System (INIS)

    Dobson, J.E.

    1975-01-01

    Since 1974 Oak Ridge National Laboratory (ORNL) has been engaged in developing an automated procedure for land use suitability screening. The Nuclear Regulatory Commission has funded the project to aid in the selection of power plant sites in Maryland. Its purpose is to identify candidate areas from which specific candidate sites can be chosen for detailed analyses. The ORNL approach assures that certain key variables are examined empirically for every cell in the study region before candidate sites are selected. Each variable is assigned an importance weight and compatibility score based upon its effect on the economic, social, or ecologic costs associated with construction in a given cell. The weighted scores for each variable are aggregated and output as a suitability score for each cell

  12. Site Suitability For Yam, Rice And Cotton Production In Adamawa ...

    African Journals Online (AJOL)

    This paper demonstrated the potentials of GIS technique for mapping and delineating the suitable sites for Yam, Rice and Cotton production in Adamawa State. Site suitability mapping is necessary to create data bank and to guide the farmers in decision making on sites for crop production in the state. The use of GIS for this ...

  13. Report of early site suitability evaluation of the potential repository site at Yucca Mountain, Nevada; Yucca Mountain Site Characterization Project

    Energy Technology Data Exchange (ETDEWEB)

    Younker, J.L.; Andrews, W.B.; Fasano, G.A.; Herrington, C.C.; Mattson, S.R.; Murray, R.C. [Science Applications International Corp., Las Vegas, NV (United States); Ballou, L.B.; Revelli, M.A. [Lawrence Livermore National Lab., CA (United States); Ducharme, A.R.; Shephard, L.E. [Sandia National Labs., Albuquerque, NM (United States); Dudley, W.W.; Hoxie, D.T. [Geological Survey, Denver, CO (United States); Herbst, R.J.; Patera, E.A. [Los Alamos National Lab., NM (United States); Judd, B.R. [Decision Analysis Co., Portola Valley, CA (United States); Docka, J.A.; Rickertsen, L.D. [Weston Technical Associates, Washington, DC (United States)

    1992-01-01

    This study evaluated the technical suitability of Yucca Mountain, Nevada, as a potential site for a mined geologic repository for the permanent disposal of radioactive waste. The evaluation was conducted primarily to determine early in the site characterization program if there are any features or conditions at the site that indicate it is unsuitable for repository development. A secondary purpose was to determine the status of knowledge in the major technical areas that affect the suitability of the site. This early site suitability evaluation (ESSE) was conducted by a team of technical personnel at the request of the Associate Director of the US Department of Energy (DOE) Office of Geologic Disposal, a unit within the DOE`s Office of Civilian Radioactive Waste Management. The Yucca Mountain site has been the subject of such evaluations for over a decade. In 1983, the site was evaluated as part of a screening process to identify potentially acceptable sites. The site was evaluated in greater detail and found suitable for site characterization as part of the Environmental Assessment (EA) (DOE, 1986) required by the Nuclear Waste Policy Act of 1982 (NWPA). Additional site data were compiled during the preparation of the Site Characterization Plan (SCP) (DOE, 1988a). This early site suitability evaluation has considered information that was used in preparing both-documents, along with recent information obtained since the EA and SCP were published. This body of information is referred to in this report as ``current information`` or ``available evidence.``

  14. Solid waste dumping site suitability analysis using geographic ...

    African Journals Online (AJOL)

    Solid waste dumping is a serious problem in the urban areas because most solid wastes are not dumped in the suitable areas. Bahir Dar Town has the problem of solid waste dumping site identification. The main objective of this study was to select potential areas for suitable solid waste dumping sites for Bahir Dar Town, ...

  15. Site suitability analysis and route optimization for solid waste ...

    African Journals Online (AJOL)

    Solid waste management system is a tedious task that is facing both developing and developed countries. Site Suitability analysis and route optimization for solid waste disposal can make waste management cheap and can be used for sustainable development. However, if the disposal site(s) is/are not sited and handle ...

  16. 76 FR 82201 - General Site Suitability Criteria for Nuclear Power Stations

    Science.gov (United States)

    2011-12-30

    ... guidelines in identifying suitable candidate sites for nuclear power stations. The decision that a station... combination and a cost-benefit analysis comparing it with alternative site-plant combinations, as discussed in...

  17. Selecting Suitable Sites for Wind Energy Development in Ghana ...

    African Journals Online (AJOL)

    Selecting Suitable Sites for Wind Energy Development in Ghana. ... In the event of shortages in petroleum products, these power plants will have ... Layers of these criteria setting were combined using the overlay function in a GIS environment.

  18. Evaluation of the suitability of the WIPP site

    International Nuclear Information System (INIS)

    Neill, R.H.; Channell, J.K.; Chaturvedi, L.; Little, M.S.; Rehfeldt, K.; Spiegler, P.

    1983-05-01

    Determination of the suitability of the site for WIPP is only the first major phase in the evaluation of the radiological impact of the repository on the public health and safety. The Environmental Evaluation Group (EEG) will continue to independently review the design of the facility, the operational procedures, the criteria for packaging and shipment of the waste, the plans, procedures and results of the WIPP experiments, emergency preparedness, adherence to EPA and pertinent NRC regulations, and other important features of the project. EEG has concluded from existing evidence that the Los Medanos site for the WIPP project has been characterized in sufficient detail to warrant confidence in the validation of the site for the permanent emplacement of approximately 6 million cubic feet of defense transuranic waste. This conclusion is based on the assumption that the maximum surface dose rate for the unshielded remote-handled transuranic waste canisters will be 100 rem/hr with a maximum radionuclide concentration of 23 Ci/liter. The Site and Preliminary Design Validation program, through the drilling of two shafts to the selected repository level at 2160 ft below the surface and excavation of about 9000 ft of tunnels, has confirmed the interpretations made about the subsurface geological conditions at the site. For an assessment of the potential radiation effects of the nuclear waste repository on the public health and safety, it is necessary to understand the regional geological and hydrological setting. Much work has been done to understand these conditions and to address several specific issues which have arisen as a result of such studies. However, it is almost inevitable that some questions remain unanswered at a given time in the decision-making process. EEG has identified work which still needs to be done at the Los Medanos site in order to improve confidence in the worst case scenario models of possible breaches of the repository

  19. Less is more: Strategic scale site suitability for concentrated solar thermal power in Western Australia

    International Nuclear Information System (INIS)

    Dawson, Lucas; Schlyter, Peter

    2012-01-01

    Concentrated Solar Thermal Power (CSP) represents a technology with a great deal of promise for low-emissions electricity generation. Several recent studies have identified large swathes of the world’s ‘sunbelt’ as technically suitable for the technology, but current estimates grossly overestimate site suitability for CSP. There is a need for more realistic suitability estimations in order to provide a more accurate basis for policy and investment decisions. This paper establishes a generally applicable GIS-based methodology to better enable identification of CSP-suitable sites at the continental scale. We test the methodology, identifying a large number of CSP suitable sites in Western Australia (WA). Our results indicate a 99.4% reduction from technically suitable areas to areas showing medium-to-very-high suitability in the current and near term in WA. The availability of infrastructure is critical to site suitability and the introduction of new major loads and infrastructure in currently under-developed regions is likely to open up further areas with medium to very high suitability. Despite the fact that current global/continental scale estimates of CSP potentials are likely overestimated by at least two orders of magnitude, truly CSP-suitable areas remain more than sufficient to motivate investment in utility-scale CSP and power potentials from this technology remain enormous. - Highlights: ► 1.78 million km 2 of Western Australia is identified as technically suitable. ► Hypothetical production potential of technically suitable area ≈908,000 TW h/year. ► Only 0.6% of technically suitable areas considered to be medium-very highly suitable. ► Site suitability highly dependent on availability of infrastructure and load. ► Suitable areas still more than sufficient to motivate CSP production.

  20. Site suitability criteria for solidified high level waste repositories

    International Nuclear Information System (INIS)

    Heckman, R.A.; Holdsworth, T.; Towse, D.F.

    1979-01-01

    Activities devoted to development of regulations, criteria, and standards for storage of solidified high-level radioactive wastes are reported. The work is summarized in sections on site suitability regulations, risk calculations, geological models, aquifer models, human usage model, climatology model, and repository characteristics. Proposed additional analytical work is also summarized

  1. Solid waste dumping site suitability analysis using geographic ...

    African Journals Online (AJOL)

    Solid waste dumping site suitability analysis using geographic information system (GIS) and remote sensing for Bahir Dar Town, North Western Ethiopia. ... The PDF file you selected should load here if your Web browser has a PDF reader plug-in installed (for example, a recent version of Adobe Acrobat Reader).

  2. A new methodology for repository site suitability evaluation

    International Nuclear Information System (INIS)

    Miller, I.; Kossik, R.; Cunnane, M.

    1992-01-01

    Golder Associates Inc. (GAI) has developed a probabilistic total system performance assessment and strategy evaluation model (RIP) which can be applied in an iterative manner to evaluate repository site suitability and guide site characterization. The major portion of the software is the performance assessment model, which consists of a series of coupled component models for radionuclide transfer. The performance model itself is embedded within a decision analysis model which allows the user to evaluate alternative site characterization strategies. This paper provides an overview of the methodology, and summarizes the basic concepts of RIP

  3. Identification of suitable sites for mountain ginseng cultivation using GIS and geo-temperature.

    Science.gov (United States)

    Kang, Hag Mo; Choi, Soo Im; Kim, Hyun

    2016-01-01

    This study was conducted to explore an accurate site identification technique using a geographic information system (GIS) and geo-temperature (gT) for locating suitable sites for growing cultivated mountain ginseng (CMG; Panax ginseng), which is highly sensitive to the environmental conditions in which it grows. The study site was Jinan-gun, South Korea. The spatial resolution for geographic data was set at 10 m × 10 m, and the temperatures for various climatic factors influencing CMG growth were calculated by averaging the 3-year temperatures obtained from the automatic weather stations of the Korea Meteorological Administration. Identification of suitable sites for CMG cultivation was undertaken using both a conventional method and a new method, in which the gT was added as one of the most important factors for crop cultivation. The results yielded by the 2 methods were then compared. When the gT was added as an additional factor (new method), the proportion of suitable sites identified decreased by 0.4 % compared with the conventional method. However, the proportion matching real CMG cultivation sites increased by 3.5 %. Moreover, only 68.2 % corresponded with suitable sites identified using the conventional factors; i.e., 31.8 % were newly detected suitable sites. The accuracy of GIS-based identification of suitable CMG cultivation sites improved by applying the temperature factor (i.e., gT) in addition to the conventionally used factors.

  4. Geographical information system (GIS) suitability analysis of radioactive waste repository site in Pahang, Malaysia

    International Nuclear Information System (INIS)

    Faizal Azrin Abd Razalim; Noraini Surip; Ahmad Hasnulhadi; Nazran Harun; Nurul Nadia Abd Malek; Roziah Che Musa

    2010-01-01

    The aim of this project is to identify a suitable site for radioactive waste repository in Pahang using remote sensing and geographical information system (GIS) technologies. There are ten parameters considered in the analysis, which divided into Selection Criteria and Exclusion Criteria. The Selection Criteria parameters consists of land use, rainfall, lineament, slope, groundwater potential and elevation while Exclusion Criteria parameters consist of urban, protected land and island. Furthermore, all parameters were integrated, given weight age and ranked for site selection evaluation in GIS environment. At the first place, about twelve sites have been identified as suitable sites for radioactive waste repository throughout the study area. These sites were further analysed by ground checking on the physical setting including geological, drainage, and population density in order to finalise three most suitable sites for radioactive waste repository. (author)

  5. Suitability

    NARCIS (Netherlands)

    Bokdam, J.; Braeckel, van A.

    2002-01-01

    The suitability of grazing, burning, mowing and cutting as tools for succession control in peatland was assessed and expressed on a scale from 0 - 1. All management tools are suitable, but their effects are conditional. The suitability depends on the targeted vegetation transition and on their

  6. Site suitability criteria for solidified high level waste repositories

    International Nuclear Information System (INIS)

    Heckman, R.A.; Holdsworth, T.; Isherwood, D.; Towse, D.F.; Dayem, N.L.

    1979-01-01

    The NRC is developing a framework of regulations, criteria, and standards. Lawrence Livermore Laboratory provides broad technical support to the NRC for developing this regulatory framework, part of which involves site suitability criteria for solidified high-level wastes (SHLW). Both the regulatory framework and the technical base on which it rests have evolved in time. This document is the second report of the technical support project. It was issued as a draft working paper for a programmatic review held at LLL from August 16 to 18, 1977. It was printed and distributed solely as a briefing document on preliminary methodology and initial findings for the purpose of critical review by those in attendance. These briefing documents are being reprinted now in their original formats as UCID-series reports for the sake of the historical record. Analysis results have evolved as both the models and data base have changed. As a result, the methodology, models, and data base in this document are severely outmoded

  7. Evaluation of Suitability of Selected Set of Coal Plant Sites for Repowering with Small Modular Reactors

    Energy Technology Data Exchange (ETDEWEB)

    Belles, Randy [ORNL; Copinger, Donald A [ORNL; Mays, Gary T [ORNL; Omitaomu, Olufemi A [ORNL; Poore III, Willis P [ORNL

    2013-03-01

    This report summarizes the approach that ORNL developed for screening a sample set of small coal stations for possible repowering with SMRs; the methodology employed, including spatial modeling; and initial results for these sample plants. The objective in conducting this type of siting evaluation is to demonstrate the capability to characterize specific sample coal plant sites to identify any particular issues associated with repowering existing coal stations with SMRs using OR-SAGE; it is not intended to be a definitive assessment per se as to the absolute suitability of any particular site.

  8. Site Suitability and Hazard Assessment Guide for Small Modular Reactors

    Energy Technology Data Exchange (ETDEWEB)

    Wayne Moe

    2013-10-01

    Commercial nuclear reactor projects in the U.S. have traditionally employed large light water reactors (LWR) to generate regional supplies of electricity. Although large LWRs have consistently dominated commercial nuclear markets both domestically and abroad, the concept of small modular reactors (SMRs) capable of producing between 30 MW(t) and 900 MW(t) to generating steam for electricity is not new. Nor is the idea of locating small nuclear reactors in close proximity to and in physical connection with industrial processes to provide a long-term source of thermal energy. Growing problems associated continued use of fossil fuels and enhancements in efficiency and safety because of recent advancements in reactor technology suggest that the likelihood of near-term SMR technology(s) deployment at multiple locations within the United States is growing. Many different types of SMR technology are viable for siting in the domestic commercial energy market. However, the potential application of a particular proprietary SMR design will vary according to the target heat end-use application and the site upon which it is proposed to be located. Reactor heat applications most commonly referenced in connection with the SMR market include electric power production, district heating, desalinization, and the supply of thermal energy to various processes that require high temperature over long time periods, or a combination thereof. Indeed, the modular construction, reliability and long operational life purported to be associated with some SMR concepts now being discussed may offer flexibility and benefits no other technology can offer. Effective siting is one of the many early challenges that face a proposed SMR installation project. Site-specific factors dealing with support to facility construction and operation, risks to the plant and the surrounding area, and the consequences subsequent to those risks must be fully identified, analyzed, and possibly mitigated before a license

  9. Marine Benthic Habitats and Seabed Suitability Mapping for Potential Ocean Current Energy Siting Offshore Southeast Florida

    Directory of Open Access Journals (Sweden)

    Amanda Mulcan

    2015-05-01

    Full Text Available This study examines the legal framework for ocean current energy policy and regulation to develop a metric for assessing the biological and geological characteristics of a seabed area with respect to the siting of OCE devices, a framework of criteria by which to assess seabed suitability (seabed suitability framework that can facilitate the siting, and implementation of ocean current energy (OCE projects. Seafloor geology and benthic biological data were analyzed in conjunction with seafloor core sample geostatistical interpolation to locate suitable substrates for OCE anchoring. Existing submarine cable pathways were considered to determine pathways for power transmission cables that circumvent biologically sensitive areas. Suitability analysis indicates that areas east of the Miami Terrace and north of recently identified deep-sea coral mounds are the most appropriate for OCE siting due to abundance of sand/sediment substrate, existing underwater cable route access, and minimal biological presence (i.e., little to no benthic communities. Further reconnaissance requires higher resolution maps of geological substrate and benthic community locations to identify specific OCE development locations, classify benthic conditions, and minimize potentially negative OCE environmental impacts.

  10. Selecting Suitable Sites for Mine Waste Dumps Using GIS ...

    African Journals Online (AJOL)

    Michael

    2017-06-01

    Jun 1, 2017 ... number of factors such as financial, environmental and safety requirements ... Applying further constraints, 2 out of the 21 optimal sites were determined as the best sites. ... Most mining companies use different methods for.

  11. SitesIdentify: a protein functional site prediction tool

    Directory of Open Access Journals (Sweden)

    Doig Andrew J

    2009-11-01

    Full Text Available Abstract Background The rate of protein structures being deposited in the Protein Data Bank surpasses the capacity to experimentally characterise them and therefore computational methods to analyse these structures have become increasingly important. Identifying the region of the protein most likely to be involved in function is useful in order to gain information about its potential role. There are many available approaches to predict functional site, but many are not made available via a publicly-accessible application. Results Here we present a functional site prediction tool (SitesIdentify, based on combining sequence conservation information with geometry-based cleft identification, that is freely available via a web-server. We have shown that SitesIdentify compares favourably to other functional site prediction tools in a comparison of seven methods on a non-redundant set of 237 enzymes with annotated active sites. Conclusion SitesIdentify is able to produce comparable accuracy in predicting functional sites to its closest available counterpart, but in addition achieves improved accuracy for proteins with few characterised homologues. SitesIdentify is available via a webserver at http://www.manchester.ac.uk/bioinformatics/sitesidentify/

  12. Deep geological repository: Starting communication at potentially suitable sites

    International Nuclear Information System (INIS)

    Sumberova, Vera

    2001-01-01

    The siting of a deep geological repository in the Czech Republic is and will be a complicated process, since it is the first siting process of a nuclear facility designed from the start to be located at non-nuclear sites and to be organised under democratic conditions. This presentation describes the concept of radioactive waste and spent nuclear management in the Czech Republic, Communication activities of Radioactive Waste Repository Authority (RAWRA) with local representatives and lessons learned

  13. Selecting Suitable Sites for Wind Energy Development in Ghana*

    African Journals Online (AJOL)

    Michae O. Mensah

    2016-06-01

    Jun 1, 2016 ... Ghana's wind power potential both on-shore and off-shore. ..... such as forest and game reserves, tourist sites, etc. (iv) Siting in lakes is restricted. (v) Slopes greater than 30° ... Atlantic coastline that stretches 560 km along the.

  14. Predicting Greater Prairie-Chicken Lek Site Suitability to Inform Conservation Actions.

    Directory of Open Access Journals (Sweden)

    Torre J Hovick

    Full Text Available The demands of a growing human population dictates that expansion of energy infrastructure, roads, and other development frequently takes place in native rangelands. Particularly, transmission lines and roads commonly divide rural landscapes and increase fragmentation. This has direct and indirect consequences on native wildlife that can be mitigated through thoughtful planning and proactive approaches to identifying areas of high conservation priority. We used nine years (2003-2011 of Greater Prairie-Chicken (Tympanuchus cupido lek locations totaling 870 unique leks sites in Kansas and seven geographic information system (GIS layers describing land cover, topography, and anthropogenic structures to model habitat suitability across the state. The models obtained had low omission rates (0.81, indicating high model performance and reliability of predicted habitat suitability for Greater Prairie-Chickens. We found that elevation was the most influential in predicting lek locations, contributing three times more predictive power than any other variable. However, models were improved by the addition of land cover and anthropogenic features (transmission lines, roads, and oil and gas structures. Overall, our analysis provides a hierarchal understanding of Greater Prairie-Chicken habitat suitability that is broadly based on geomorphological features followed by land cover suitability. We found that when land features and vegetation cover are suitable for Greater Prairie-Chickens, fragmentation by anthropogenic sources such as roadways and transmission lines are a concern. Therefore, it is our recommendation that future human development in Kansas avoid areas that our models identified as highly suitable for Greater Prairie-Chickens and focus development on land cover types that are of lower conservation concern.

  15. IDENTIFYING OPERATIONAL REQUIREMENTS TO SELECT SUITABLE DECISION MODELS FOR A PUBLIC SECTOR EPROCUREMENT DECISION SUPPORT SYSTEM

    Directory of Open Access Journals (Sweden)

    Mohamed Adil

    2014-10-01

    Full Text Available Public sector procurement should be a transparent and fair process. Strict legal requirements are enforced on public sector procurement to make it a standardised process. To make fair decisions on selecting suppliers, a practical method which adheres to legal requirements is important. The research that is the base for this paper aimed at identifying a suitable Multi-Criteria Decision Analysis (MCDA method for the specific legal and functional needs of the Maldivian Public Sector. To identify such operational requirements, a set of focus group interviews were conducted in the Maldives with public officials responsible for procurement decision making. Based on the operational requirements identified through focus groups, criteria-based evaluation is done on published MCDA methods to identify the suitable methods for e-procurement decision making. This paper describes the identification of the operational requirements and the results of the evaluation to select suitable decision models for the Maldivian context.

  16. Identifying Suitable Locations for Mesophotic Hard Corals Offshore of Maui, Hawai'i.

    Directory of Open Access Journals (Sweden)

    Bryan Costa

    approach may be used to identify other potentially suitable areas for MHCs, helping scientists and resource managers prioritize sites, and focus their limited resources on areas that may be of higher scientific or conservation value.

  17. Suitable Site Selection of Small Dams Using Geo-Spatial Technique: a Case Study of Dadu Tehsil, Sindh

    Science.gov (United States)

    Khalil, Zahid

    2016-07-01

    Decision making about identifying suitable sites for any project by considering different parameters, is difficult. Using GIS and Multi-Criteria Analysis (MCA) can make it easy for those projects. This technology has proved to be an efficient and adequate in acquiring the desired information. In this study, GIS and MCA were employed to identify the suitable sites for small dams in Dadu Tehsil, Sindh. The GIS software is used to create all the spatial parameters for the analysis. The parameters that derived are slope, drainage density, rainfall, land use / land cover, soil groups, Curve Number (CN) and runoff index with a spatial resolution of 30m. The data used for deriving above layers include 30 meter resolution SRTM DEM, Landsat 8 imagery, and rainfall from National Centre of Environment Prediction (NCEP) and soil data from World Harmonized Soil Data (WHSD). Land use/Land cover map is derived from Landsat 8 using supervised classification. Slope, drainage network and watershed are delineated by terrain processing of DEM. The Soil Conservation Services (SCS) method is implemented to estimate the surface runoff from the rainfall. Prior to this, SCS-CN grid is developed by integrating the soil and land use/land cover raster. These layers with some technical and ecological constraints are assigned weights on the basis of suitability criteria. The pair wise comparison method, also known as Analytical Hierarchy Process (AHP) is took into account as MCA for assigning weights on each decision element. All the parameters and group of parameters are integrated using weighted overlay in GIS environment to produce suitable sites for the Dams. The resultant layer is then classified into four classes namely, best suitable, suitable, moderate and less suitable. This study reveals a contribution to decision making about suitable sites analysis for small dams using geo-spatial data with minimal amount of ground data. This suitability maps can be helpful for water resource

  18. Site suitability, selection and characterization: Branch technical position--Low-Level Waste Licensing Branch

    International Nuclear Information System (INIS)

    Siefken, D.; Pangburn, G.; Pennifill, R.; Starmer, R.J.

    1982-04-01

    The staff provides an expanded interpretation of the site suitability requirements in the proposed rule 10 CFR Part 61, a description of the anticipated site selection process, and a detailed discussion of the site characterization program needed to support a license application and environmental report. The paper provides early-on guidance to prospective applicants in these three subject areas

  19. Mapping Suitable Sites for Setting up Wind Farms: A Case Study of ...

    African Journals Online (AJOL)

    Mapping Suitable Sites for Setting up Wind Farms: A Case Study of Nyanga District. ... Ethiopian Journal of Environmental Studies and Management ... sources and continuous power shortages make wind energy a very attractive alternative to ...

  20. SPATIAL DATA MINING TOOLBOX FOR MAPPING SUITABILITY OF LANDFILL SITES USING NEURAL NETWORKS

    Directory of Open Access Journals (Sweden)

    S. K. M. Abujayyab

    2016-09-01

    Full Text Available Mapping the suitability of landfill sites is a complex field and is involved with multidiscipline. The purpose of this research is to create an ArcGIS spatial data mining toolbox for mapping the suitability of landfill sites at a regional scale using neural networks. The toolbox is constructed from six sub-tools to prepare, train, and process data. The employment of the toolbox is straightforward. The multilayer perceptron (MLP neural networks structure with a backpropagation learning algorithm is used. The dataset is mined from the north states in Malaysia. A total of 14 criteria are utilized to build the training dataset. The toolbox provides a platform for decision makers to implement neural networks for mapping the suitability of landfill sites in the ArcGIS environment. The result shows the ability of the toolbox to produce suitability maps for landfill sites.

  1. Development of site suitability criteria for the high level waste repository for Lawrence Livermore Laboratories

    International Nuclear Information System (INIS)

    1977-06-01

    Results of our mining, geological and geotechnical studies provided in support of the development of site suitability criteria for the high level waste repository are presented. The primary purpose of the work was the identification and development of appropriate geotechnical descriptors and coefficients required for the Site Suitability Repository Model. This model was developed by The Analytic Sciences Corporation (TASC) of Reading, Massachusetts and is not described in this report

  2. Development of site suitability criteria for the high level waste repository for Lawrence Livermore Laboratories

    Energy Technology Data Exchange (ETDEWEB)

    1977-06-01

    Results of our mining, geological and geotechnical studies provided in support of the development of site suitability criteria for the high level waste repository are presented. The primary purpose of the work was the identification and development of appropriate geotechnical descriptors and coefficients required for the Site Suitability Repository Model. This model was developed by The Analytic Sciences Corporation (TASC) of Reading, Massachusetts and is not described in this report.

  3. Identifying Areas Suitable for the Occurrence of Rift Valley Fever in North Africa: Implications for Surveillance.

    Science.gov (United States)

    Arsevska, E; Hellal, J; Mejri, S; Hammami, S; Marianneau, P; Calavas, D; Hénaux, V

    2016-12-01

    Rift Valley fever (RVF) is a vector-borne zoonotic disease that has caused widespread outbreaks throughout Africa and the Arabian Peninsula, with serious consequences for livestock-based economies and public health. Although there have never been any reports of RVF in Morocco, Algeria, Tunisia and Libya, it is a priority disease in the Maghreb, due to the threat of introduction of the virus through transboundary livestock movements or infected mosquito vectors. However, the implementation of surveillance activities and early warning contingency plans requires better knowledge of the epidemiological situation. We conducted a multicriteria decision analysis, integrating host distribution with a combination of important ecological factors that drive mosquito abundance, to identify hotspots and suitable time periods for RVF enzootic circulation (i.e. stable transmission at a low to moderate level for an extended period of time) and an RVF epizootic event (i.e. a sudden occurrence of a large number of infected animals over a large geographic area) in the Maghreb. We also modelled vector species distribution using available information on vector presence and habitat preference. We found that the northern regions of the Maghreb were moderately suitable for RVF enzootics, but highly suitable for RVF epizootics. The vector species distribution model identified these regions as the most favourable mosquito habitats. Due to the low density of animal hosts and arid conditions, the desert region showed low RVF suitability, except in oases. However, the presence of competent vectors in putative unsuitable areas underlines the need for further assessments of mosquito habitat preference. This study produced monthly RVF suitability maps useful for animal health managers and veterinary services involved in designing risk-based surveillance programmes. The suitability maps can be further enhanced using existing country-specific sources of information and by incorporating knowledge

  4. A GIS based screening tool for locating and ranking of suitable stormwater harvesting sites in urban areas.

    Science.gov (United States)

    Inamdar, P M; Cook, S; Sharma, A K; Corby, N; O'Connor, J; Perera, B J C

    2013-10-15

    There is the need to re-configure current urban water systems to achieve the objective of sustainable water sensitive cities. Stormwater represents a valuable alternative urban water source to reduce pressure on fresh water resources, and to mitigate the environmental impact of urban stormwater runoff. The selection of suitable urban stormwater harvesting sites is generally based on the judgement of water planners, who are faced with the challenge of considering multiple technical and socio-economic factors that influence the site suitability. To address this challenge, the present study developed a robust GIS based screening methodology for identifying potentially suitable stormwater harvesting sites in urban areas as a first pass for then more detailed investigation. The study initially evaluated suitability based on the match between harvestable runoff and demand through a concept of accumulated catchments. Drainage outlets of these accumulated catchments were considered as potential stormwater harvesting sites. These sites were screened and ranked under screening parameters namely demand, ratio of runoff to demand and weighted demand distance. The methodology described in this paper was successfully applied to a case study in Melbourne, Australia in collaboration with the local water utility. The methodology was found to be effective in supporting the selection of priority sites for stormwater harvesting schemes, as it provided the basis to identify, short-list and rank sites for further detailed investigation. The rapid identification of suitable sites for stormwater harvesting can assist planners in prioritising schemes in areas that will have the most impact on reducing potable water demand. Copyright © 2013 Elsevier Ltd. All rights reserved.

  5. Using Geographic Information Systems to Determine Site Suitability for a Low-Level Radioactive Waste Storage Facility.

    Science.gov (United States)

    Wilson, Charles A; Matthews, Kennith; Pulsipher, Allan; Wang, Wei-Hsung

    2016-02-01

    Radioactive waste is an inevitable product of using radioactive material in education and research activities, medical applications, energy generation, and weapons production. Low-level radioactive waste (LLW) makes up a majority of the radioactive waste produced in the United States. In 2010, over two million cubic feet of LLW were shipped to disposal sites. Despite efforts from several states and compacts as well as from private industry, the options for proper disposal of LLW remain limited. New methods for quickly identifying potential storage locations could alleviate current challenges and eventually provide additional sites and allow for adequate regional disposal of LLW. Furthermore, these methods need to be designed so that they are easily communicated to the public. A Geographic Information Systems (GIS) based method was developed to determine suitability of potential LLW disposal (or storage) sites. Criteria and other parameters of suitability were based on the Code of Federal Regulation (CFR) requirements as well as supporting literature and reports. The resultant method was used to assess areas suitable for further evaluation as prospective disposal sites in Louisiana. Criteria were derived from the 10 minimum requirements in 10 CFR Part 61.50, the Nuclear Regulatory Commission's Regulatory Guide 0902, and studies at existing disposal sites. A suitability formula was developed permitting the use of weighting factors and normalization of all criteria. Data were compiled into GIS data sets and analyzed on a cell grid of approximately 14,000 cells (covering 181,300 square kilometers) using the suitability formula. Requirements were analyzed for each cell using multiple criteria/sub-criteria as well as surrogates for unavailable datasets. Additional criteria were also added when appropriate. The method designed in this project proved to be sufficient for initial screening tests in determining the most suitable areas for prospective disposal (or storage

  6. Report of the Peer Review Panel on the early site suitability evaluation of the Potential Repository Site at Yucca Mountain, Nevada; Yucca Mountain Site Characterization Project

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1992-01-01

    The US Department of Energy (DOE) Yucca mountain Site Characterization Project Office (YMPO) assigned Science Applications International Corporation (SAIC), the Technical and Management Support Services (T&MSS) contractor to the YmPo, the task of conducting an Early Site Suitability Evaluation (ESSE) of the Yucca mountain site as a potential site for a high-level radioactive waste repository. First, the assignment called for the development of a method to evaluate a single site against the DOE General Guidelines for Recommendation of Sites for Nuclear Waste Repositories, 10 CFR Part 960. Then, using this method, an evaluation team, the ESSE Core Team, of senior YMP scientists, engineers, and technical experts, evaluated new information obtained about the site since publication of the final Environmental Assessment (DOE, 1986) to determine if new suitability/unsuitability findings could be recommended. Finally, the Core Team identified further information and analyses needed to make final determinations for each of the guidelines. As part of the task, an independent peer review of the ESSE report has been conducted. Expertise was solicited that covered the entire spectrum of siting guidelines in 10 CFR Part 960 in order to provide a complete, in-depth critical review of the data evaluated and cited in the ESSE report, the methods used to evaluate the data, and the conclusions and recommendations offered by the report. Fourteen nationally recognized technical experts (Table 2) served on the Peer Review Panel. The comments from the Panel and the responses prepared by the ESSE Core Team, documented on formal Comment Response Forms, constitute the body of this document.

  7. Identification of suitable sites for rainwater harvesting structures in arid and semi-arid regions: A review

    Directory of Open Access Journals (Sweden)

    Ammar Adham

    2016-06-01

    Full Text Available Harvested rainwater is an alternative source of water in arid and semi-arid regions (ASARs around the world. Many researchers have developed and applied various methodologies and criteria to identify suitable sites and techniques for rainwater harvesting (RWH. Determining the best method or guidelines for site selection, however, is difficult. The main objective of this study was to define a general method for selecting suitable RWH sites in ASARs by assembling an inventory of the main methods and criteria developed during the last three decades. We categorised and compared four main methodologies of site selection from 48 studies published in scientific journals, reports of international organisations, or sources of information obtained from practitioners. We then identified three main sets of criteria for selecting RWH locations and the main characteristics of the most common RWH techniques used in ASARs. The methods were diverse, ranging from those based only on biophysical criteria to more integrated approaches including socio-economic criteria, especially after 2000. The most important criteria for the selection of suitable sites for RWH were slope, land use/cover, soil type, rainfall, distance to settlements/streams, and cost. The success rate of RWH projects tended to increase when these criteria were considered, but an objective evaluation of these selection methods is still lacking. Most studies now select RHW sites using geographic information systems in combination with hydrological models and multi-criteria analysis.

  8. Geographic factors related to site suitability of low-level waste disposal

    International Nuclear Information System (INIS)

    Zittel, H.E.

    1981-01-01

    A number of factors related to the site suitability of low-level waste disposal sites are discussed. The factors are a combination of those which might be considered environmental and those dealing with site criteria. Among the factors covered are: possible population criteria, alternative site selection, transportation criteria and community involvement considerations. All these factors are discussed in a manner based on the premise that the technology exists to carry out low-level waste disposal in a manner such that public health and safety can be insured. The conclusion of the discussion is that problems encountered in siting low-level waste facilities will be largely societal and political in nature

  9. Geographic factors related to site suitability of low-level waste disposal

    Science.gov (United States)

    Zittel, H. E.

    Factors related to the site suitability of low level waste disposal sites are discussed including those which might be considered environmental and those dealing with site criteria. Possible population criteria, alternative site selection, transportation criteria, and community involvement are considered. All these factors are based on the premise that the technology exists to carry out low level waste disposal in a manner such that public health and safety can be insured. It is concluded that problems encountered in siting low level waste facilities are largely societal and political in nature.

  10. Environmental siting suitability analysis for commercial scale ocean renewable energy: A southeast Florida case study

    Science.gov (United States)

    Mulcan, Amanda

    This thesis aims to facilitate the siting and implementation of Florida Atlantic University Southeast National Marine Renewable Energy Center (FAU SNMREC) ocean current energy (OCE) projects offshore southeastern Florida through the analysis of benthic anchoring conditions. Specifically, a suitability analysis considering all presently available biologic and geologic datasets within the legal framework of OCE policy and regulation was done. OCE related literature sources were consulted to assign suitability levels to each dataset, ArcGIS interpolations generated seafloor substrate maps, and existing submarine cable pathways were considered for OCE power cables. The finalized suitability map highlights the eastern study area as most suitable for OCE siting due to its abundance of sand/sediment substrate, existing underwater cable route access, and minimal biologic presence. Higher resolution datasets are necessary to locate specific OCE development locales, better understand their benthic conditions, and minimize potentially negative OCE environmental impacts.

  11. Nuclear Energy Center study. Phase II. Site suitability analysis. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Fellows, W.S.; Sharp, J.M.; Benator, B.I.

    1978-06-01

    A site screening study was conducted to identify a site or sites for detailed, site-specific study as a nuclear energy center. Using technical criteria of water requirements, geotechnical constraints, and projected load center and transmission considerations as well as environmental and institutional considerations, five potential study sites in the State of South Carolina were identified, evaluated against established criteria, and ranked according to their acceptability as potential nuclear energy center study sites. Consideration of what is ''representative'' of a site as well as the ranking score was factored into site recommendations, since the site deemed easiest to license and permit may not be the most desirable site for future study of the technical and institutional feasibility and practicality of a specific site. The sites near Lake Hartwell and the Savannah River Plant (SRP) of the Department of Energy were selected as potential study sites after consideration of the above criteria. Because the Lake Hartwell site offers the opportunity to consider institutional issues which may be more representative of other possible NEC sites, it is recommended that the Lake Hartwell site be studied to establish the feasibility and practicality of the nuclear energy concept on a site-specific basis.

  12. Nuclear Energy Center study. Phase II. Site suitability analysis. Final report

    International Nuclear Information System (INIS)

    Fellows, W.S.; Sharp, J.M.; Benator, B.I.

    1978-06-01

    A site screening study was conducted to identify a site or sites for detailed, site-specific study as a nuclear energy center. Using technical criteria of water requirements, geotechnical constraints, and projected load center and transmission considerations as well as environmental and institutional considerations, five potential study sites in the State of South Carolina were identified, evaluated against established criteria, and ranked according to their acceptability as potential nuclear energy center study sites. Consideration of what is ''representative'' of a site as well as the ranking score was factored into site recommendations, since the site deemed easiest to license and permit may not be the most desirable site for future study of the technical and institutional feasibility and practicality of a specific site. The sites near Lake Hartwell and the Savannah River Plant (SRP) of the Department of Energy were selected as potential study sites after consideration of the above criteria. Because the Lake Hartwell site offers the opportunity to consider institutional issues which may be more representative of other possible NEC sites, it is recommended that the Lake Hartwell site be studied to establish the feasibility and practicality of the nuclear energy concept on a site-specific basis

  13. Identifying plant traits: a key aspect for suitable species selection in ecological restoration of semiarid slopes

    Science.gov (United States)

    Bochet, Esther; García-Fayos, Patricio

    2017-04-01

    In the context of ecological restoration, one of the greatest challenges for practitioners and scientists is to select suitable species for revegetation purposes. In semiarid environments where restoration projects often fail, little attention has been paid so far to the contribution of plant traits to species success. The objective of this study was to (1) identify plant traits associated with species success on four roadside situations along an erosion-productivity gradient, and (2) to provide an ecological framework for selecting suitable species on the basis of their morphological and functional traits, applied to semiarid environments. We analyzed the association of 10 different plant traits with species success of 296 species surveyed on the four roadside situations in a semiarid region (Valencia, Spain). Plant traits included general plant traits (longevity, woodiness) and more specific root-, seed- and leaf-related traits (root type, sprouting ability, seed mucilage, seed mass, seed susceptibility to removal, specific leaf area and leaf dry matter content). All of them were selected according to the prevailing limiting ecogeomorphological processes acting along the erosion-productivity gradient. We observed strong shifts along the erosion-productivity gradient in the traits associated to species success. At the harshest end of the gradient, the most intensely eroded and driest one, species success was mainly associated to seed resistance to removal by runoff and to resistance to drought. At the opposite end of the gradient, the most productive one, species success was associated to a competitive-ruderal plant strategy (herbaceous successful species with high specific leaf area and low leaf dry matter content). Our study provides an ecologically-based approach for selecting suitable native species on the basis or their morphological and functional traits and supports a differential trait-based selection of species as regards roadslope type and aspect. In

  14. Site suitability to tourist use or management programs South Marsa Alam, Red Sea, Egypt

    Directory of Open Access Journals (Sweden)

    AMRO ABD-ELHAMID ABD-ELGAWAD

    2011-01-01

    Full Text Available Ammar MSA, Hassanein M, Madkour HA, Abd-Elgawad AE. 2011. Site suitability to tourist use or management programs South Marsa Alam, Red Sea, Egypt. Nusantara Bioscience 3: 36-43. Twenty sites in the southern Egyptian Red Sea (Marsa Alam-Ras Banas sector were surveyed principally for sensitivity significance throughout the periode 2002-2003. Sensitivity of the study area was derived from internationally known criteria, the key words of each criterion and a brief description of its use was described. The present study assigned for the first time a numerical total environmental significance score that gives a full sensitivity significance evaluation for any site to decide to select either for tourist use or management purposes. However, the results of the study still have the availability to arrange sites with respect to one criterion or only two or many of the used criteria whichever needed. Sites selected for protection are categorized as belonging to the following protected area categories: sites 7, 10 (category vi, site 18 (category ib, site 5 (category iv, sites 16, 17 (category ii. Sites selected for tourist uses are suggested to be classified into 2 categories: first category sites (sites 1, 3, 8, 11, 13, 15 which are recommended as tourist use sites with management of the sensitive resources beside non consumptive recreational activities like swimming, diving, boating, surfing, wind-surfing, jet skiing, bird watching, snorkelling, etc.; second category sites (sites 2, 4, 6, 9, 12, 14, 19, 20 which are recommended as tourist use sites with both non consumptive and managed consumptive recreational activities like fishing.

  15. A GIS- Based suitability analysis for siting a solid waste in an urban area

    Directory of Open Access Journals (Sweden)

    M. Salemi

    2017-01-01

    Full Text Available An appropriate solid waste disposal has been a major problem in municipal environment. The use of landfills is the most economical and environmentally acceptable method for the disposal of solid waste all over the world. The analysis of spatial data and consideration of regulation and accepted criteria are part of the important elements in the site selection. The aim of this paper is to show how application of geographic information system could be used for siting solid waste disposal in Abadan city. In this paper, we consider types of soil suitable for solid waste disposals, land use/ land cover, transportation routes and proximity to surface water. Relative importance weight of each criteria in the geographic information system was determined and finally suitability map was prepared. Based on the final suitability map, appropriate solid waste landfill site was located in north east part of the study area. Select the best landfill site among the candidate ones, and   the output results can enable decision makers to make appropriate decisions to reduce the costs both in   economic and environmental criteria.

  16. Second report: development of site suitability criteria for the high level waste repository for Lawrence Livermore Laboratory

    International Nuclear Information System (INIS)

    1977-11-01

    Results are presented of mining and geotechnical studies provided to the University in support of the development of site suitability criteria. The work involved literature research, further evaluation of geotechnical and mining site suitability factors, further development of specific geotechnical descriptions and coefficients relating to uncertainties, additional documentation of descriptors and coefficients developed for the Cycle II model, and geotechnical and mining guidance to the overall LLL site suitability work. Work results are summarized in sections on general site suitability, geotechnical data base, descriptors and coefficients, uncertainty considerations, natural resources, hydrology, geology, and documentation

  17. SITE SUITABILITY ANALYSIS FOR BEEKEEPING VIA ANALYTHICAL HYREARCHY PROCESS, KONYA EXAMPLE

    Directory of Open Access Journals (Sweden)

    F. Sarı

    2017-11-01

    Full Text Available Over the past decade, the importance of the beekeeping activities has been emphasized in the field of biodiversity, ecosystems, agriculture and human health. Thus, efficient management and deciding correct beekeeping activities seems essential to maintain and improve productivity and efficiency. Due to this importance, considering the economic contributions to the rural area, the need for suitability analysis concept has been revealed. At this point, Multi Criteria Decision Analysis (MCDA and Geographical Information Systems (GIS integration provides efficient solutions to the complex structure of decision- making process for beekeeping activities. In this study, site suitability analysis via Analytical Hierarchy Process (AHP was carried out for Konya city in Turkey. Slope, elevation, aspect, distance to water resources, roads and settlements, precipitation and flora criteria are included to determine suitability. The requirements, expectations and limitations of beekeeping activities are specified with the participation of experts and stakeholders. The final suitability map were validated with existing 117 beekeeping locations and Turkish Statistical Institute 2016 beekeeping statistics for Konya province.

  18. Site Suitability Analysis for Beekeeping via Analythical Hyrearchy Process, Konya Example

    Science.gov (United States)

    Sarı, F.; Ceylan, D. A.

    2017-11-01

    Over the past decade, the importance of the beekeeping activities has been emphasized in the field of biodiversity, ecosystems, agriculture and human health. Thus, efficient management and deciding correct beekeeping activities seems essential to maintain and improve productivity and efficiency. Due to this importance, considering the economic contributions to the rural area, the need for suitability analysis concept has been revealed. At this point, Multi Criteria Decision Analysis (MCDA) and Geographical Information Systems (GIS) integration provides efficient solutions to the complex structure of decision- making process for beekeeping activities. In this study, site suitability analysis via Analytical Hierarchy Process (AHP) was carried out for Konya city in Turkey. Slope, elevation, aspect, distance to water resources, roads and settlements, precipitation and flora criteria are included to determine suitability. The requirements, expectations and limitations of beekeeping activities are specified with the participation of experts and stakeholders. The final suitability map were validated with existing 117 beekeeping locations and Turkish Statistical Institute 2016 beekeeping statistics for Konya province.

  19. Site Suitability Analysis for Dissemination of Salt-tolerant Rice Varieties in Southern Bangladesh

    Science.gov (United States)

    Sinha, D. D.; Singh, A. N.; Singh, U. S.

    2014-11-01

    Bangladesh is a country of 14.4 million ha geographical area and has a population density of more than 1100 persons per sq. km. Rice is the staple food crop, growing on about 72 % of the total cultivated land and continues to be the most important crop for food security of the country. A project "Sustainable Rice Seed Production and Delivery Systems for Southern Bangladesh" has been executed by the International Rice Research Institute (IRRI) in twenty southern districts of Bangladesh. These districts grow rice in about 2.9 million ha out of the country's total rice area of 11.3 million ha. The project aims at contributing to the Government of Bangladesh's efforts in improving national and household food security through enhanced and sustained productivity by using salinity-, submergence- and drought- tolerant and high yielding rice varieties. Out of the 20 project districts, 12 coastal districts are affected by the problem of soil salinity. The salt-affected area in Bangladesh has increased from about 0.83 million ha in 1973 to 1.02 million ha in 2000, and 1.05 million ha in 2009 due to the influence of cyclonic storms like "Sidr", "Laila" and others, leading to salt water intrusion in croplands. Three salinity-tolerant rice varieties have recently been bred by IRRI and field tested and released by the Bangladesh Rice Research Institute (BRRI) and Bangladesh Institute of Nuclear Agriculture (BINA). These varieties are BRRI dhan- 47 and Bina dhan-8 and - 10. However, they can tolerate soil salinity level up to EC 8-10 dSm-1, whereas the EC of soils in several areas are much higher. Therefore, a large scale dissemination of these varieties can be done only when a site suitability analysis of the area is carried out. The present study was taken up with the objective of preparing the site suitability of the salt-tolerant varieties for the salinity-affected districts of southern Bangladesh. Soil salinity map prepared by Soil Resources Development Institute of

  20. Wastewater Reuse: An Economic Perspective to Identify Suitable Areas for Poplar Vegetation Filter Systems for Energy Production

    Directory of Open Access Journals (Sweden)

    Mauro Viccaro

    2017-11-01

    Full Text Available The increasing interest towards climate change, water and energy saving, and soil protection has led the research community to consider non-conventional water as a sustainable source for irrigation of energy crops. Vegetation filter systems are considered a reliable technique for sustainable biomass cultivation, enabling the use of reclaimed wastewater as water and nutrients sources during irrigation periods. In this study, a geographic information system (GIS-based spatial model was developed to identify areas potentially suitable for creating vegetation filter systems with poplars to size the plants of energy production. An economic assessment allowed us to identify the cost-effectiveness areas for biomass production that can be fertigated by reclaimed wastewater. Considering the Basilicata region as the test region, a surface area of 258,512 ha was investigated, identifying 73,331 ha of SRF soils sited downstream of 45 wastewater treatment plants (WWTPs. However, considering only areas that have positive net present value and are economically attractive, results indicate 1606 ha of SRF falling within the areas of influence of 39 WWTPs. The results show that the sector of dedicated crops, adjacent and linked with WWTPs, expresses a total capacity of 50.56 MW for thermal, 8.25 MW for electricity, and 31 MW for cogeneration (25.07 MWt and 5.94 MWe plants.

  1. General basin modeling for site suitability. Draft report 1. Baseline data

    International Nuclear Information System (INIS)

    1979-04-01

    This report summarizes work completed by Golder Associates under Task 2 - Site Suitability specifically for modeling of fluid flow and mass transport in sedimentary basins containing thick shale or salt. It also describes ongoing and future work on the above topic. The purpose of the study is to develop a general model for a nuclear waste repository situated in a deep sedimentary basin environment. The model will be used in conjunction with Golder's fluid flow and mass transport codes to study specific aspects of nuclide transport by groundwater flow

  2. An integrated methodology on the suitability of offshore sites for wind farm development

    Science.gov (United States)

    Patlakas, Platon; Galanis, George; Péray, Marie; Filipot, Jean-François; Kalogeri, Christina; Spyrou, Christos; Diamantis, Dimitris; Kallos, Gerorge

    2016-04-01

    During, the last decades the potential and interest in wind energy investments has been constantly increasing in the European countries. As technology changes rapidly, more and more areas can be identified as suitable for energy applications. Offshore wind farms perfectly illustrate how new technologies allow to build bigger, more efficient and resistant in extreme conditions wind power plants. The current work proposes an integrated methodology to determine the suitability of an offshore marine area for the development of wind farm structures. More specifically, the region of interest is evaluated based both on the natural resources, connected to the local environmental characteristics, and potential constrains set by anthropogenic or other activities. State of the art atmospheric and wave models and a 10-year hindcast database are utilized in conjunction with local information for a number of potential constrains, leading to a 5-scale suitability index for the whole area. In this way, sub regions are characterized, at a high resolution mode, as poorly or highly suitable for wind farm development, providing a new tool for technical/research teams and decision makers. In addition, extreme wind and wave conditions and their 50-years return period are analyzed and used to define the safety level of the wind farms structural characteristics.

  3. Documentation information for peer group review report site suitability criteria study

    International Nuclear Information System (INIS)

    1977-10-01

    This report presents documentation of the geotechnical input data provided by Golder Associates, Inc. (GAI) for the Cycle II repository model analysis. Information relating to the proposed uncertainty analysis and several appropriate comments pertinent to the overall site suitability study are also included. GAI was responsible for developing descriptors and coefficients for the TASC model hydrologic analog; permeability and porosity values for the geologic formations (excepting salt); occurrence and properties of the bore hole seals, backfill, and mine fracture zones; and properties of fracture zones associated with faults. All data are presented with a preferred value and maximum credible range. These values relate to a generic repository in a sedimentary basin and not a specific site. 13 figures, 6 tables

  4. Requirements and criteria for choosing sites suitable for the construction of nuclear installations and power stations

    International Nuclear Information System (INIS)

    1978-05-01

    The present document explains the selection criteria for areas in Italy suitable for the installation of nuclear power stations to be included in the 'National Site Map' provided for in Section 23 of Act No 393 of 2 August 1975. It represents the results of a thorough investigation into the various aspects of the problem of siting nuclear power stations, at the present stage of technology, taking into account the effect of the installations on the environment and the effect of the environment on the installations. The essential aim is to demonstrate that the requirements derived from these analyses, and on which there was full consultation with the other controlling bodies of European countries (in particular, France, Great Britain and West Germany) ensure the optimum choice of areas from the point of view of safety and public health. (author)

  5. Report of the Peer Review Panel on the early site suitability evaluation of the Potential Repository Site at Yucca Mountain, Nevada

    International Nuclear Information System (INIS)

    1992-01-01

    The US Department of Energy (DOE) Yucca mountain Site Characterization Project Office (YMPO) assigned Science Applications International Corporation (SAIC), the Technical and Management Support Services (T ampersand MSS) contractor to the YmPo, the task of conducting an Early Site Suitability Evaluation (ESSE) of the Yucca mountain site as a potential site for a high-level radioactive waste repository. First, the assignment called for the development of a method to evaluate a single site against the DOE General Guidelines for Recommendation of Sites for Nuclear Waste Repositories, 10 CFR Part 960. Then, using this method, an evaluation team, the ESSE Core Team, of senior YMP scientists, engineers, and technical experts, evaluated new information obtained about the site since publication of the final Environmental Assessment (DOE, 1986) to determine if new suitability/unsuitability findings could be recommended. Finally, the Core Team identified further information and analyses needed to make final determinations for each of the guidelines. As part of the task, an independent peer review of the ESSE report has been conducted. Expertise was solicited that covered the entire spectrum of siting guidelines in 10 CFR Part 960 in order to provide a complete, in-depth critical review of the data evaluated and cited in the ESSE report, the methods used to evaluate the data, and the conclusions and recommendations offered by the report. Fourteen nationally recognized technical experts (Table 2) served on the Peer Review Panel. The comments from the Panel and the responses prepared by the ESSE Core Team, documented on formal Comment Response Forms, constitute the body of this document

  6. High level waste repository site suitability criteria. Environmental impact statement methodology

    International Nuclear Information System (INIS)

    1977-06-01

    The approach (methodology) which has been developed for the preparation of the environmental impact statement (EIS) is described. A suggested outline is presented for the High Level Waste Repository Site Suitability Criteria EIS together with a detailed description of the approach to be used in preparing the EIS. In addition, a methodology is presented by which the necessary cost/benefit/risk comparisons of alternative sets of site suitability criteria can be made. The TERA environmental research data bank, a computerized data bank which contained information on current and historical licensing activities for power plants was modified to include information on generic or programmatic EIS related issues. The content of the modified data bank was utilized to develop the EIS outline presented in this report. The report recommends that a modified matrix evaluation approach be used to make the cost/benefit/risk comparisons. The suggested matrix is designed to facilitate between criteria comparative analyses of economic, environmental, sociological and radiological risk factors. The quantitative compositing of dollar cost and benefits, environmental and sociological impacts, and radiological risks is to be performed using a semi-analytical, semi-visual procedure based on the concept of ''decision surfaces.''

  7. Climate change likely to reduce orchid bee abundance even in climatic suitable sites.

    Science.gov (United States)

    Faleiro, Frederico Valtuille; Nemésio, André; Loyola, Rafael

    2018-06-01

    Studies have tested whether model predictions based on species' occurrence can predict the spatial pattern of population abundance. The relationship between predicted environmental suitability and population abundance varies in shape, strength and predictive power. However, little attention has been paid to the congruence in predictions of different models fed with occurrence or abundance data, in particular when comparing metrics of climate change impact. Here, we used the ecological niche modeling fit with presence-absence and abundance data of orchid bees to predict the effect of climate change on species and assembly level distribution patterns. In addition, we assessed whether predictions of presence-absence models can be used as a proxy to abundance patterns. We obtained georeferenced abundance data of orchid bees (Hymenoptera: Apidae: Euglossina) in the Brazilian Atlantic Forest. Sampling method consisted in attracting male orchid bees to baits of at least five different aromatic compounds and collecting the individuals with entomological nets or bait traps. We limited abundance data to those obtained by similar standard sampling protocol to avoid bias in abundance estimation. We used boosted regression trees to model ecological niches and project them into six climate models and two Representative Concentration Pathways. We found that models based on species occurrences worked as a proxy for changes in population abundance when the output of the models were continuous; results were very different when outputs were discretized to binary predictions. We found an overall trend of diminishing abundance in the future, but a clear retention of climatically suitable sites too. Furthermore, geographic distance to gained climatic suitable areas can be very short, although it embraces great variation. Changes in species richness and turnover would be concentrated in western and southern Atlantic Forest. Our findings offer support to the ongoing debate of suitability

  8. Identifying Farm Pond Habitat Suitability for the Common Moorhen (Gallinula chloropus: A Conservation-Perspective Approach

    Directory of Open Access Journals (Sweden)

    Chun-Hsien Lai

    2018-04-01

    Full Text Available The purpose of this study was to establish a habitat-suitability assessment model for Gallinula chloropus, or the Common Moorhen, to be applied to the selection of the most suitable farm pond for habitat conservation in Chiayi County, Taiwan. First, the fuzzy Delphi method was employed to evaluate habitat selection factors and calculate the weights of these factors. The results showed that the eight crucial factors, by importance, in descending order, were (1 area ratio of farmlands within 200 m of the farm pond; (2 pond area; (3 pond perimeter; (4 aquatic plant coverage of the pond surface; (5 drought period; (6 coverage of high and low shrubs around the pond bank; (7 bank type; and (8 water-surface-to-bank distance. Subsequently, field evaluations of 75 farm ponds in Chiayi County were performed. The results indicated that 15 farm ponds had highly-suitable habitats and were inhabited by unusually high numbers of Common Moorhens; these habitats were most in need of conservation. A total of two farm ponds were found to require habitat-environment improvements, and Common Moorhens with typical reproductive capacity could be appropriately introduced into 22 farm ponds to restore the ecosystem of the species. Additionally, the habitat suitability and number of Common Moorhens in 36 farm ponds were lower than average; these ponds could be used for agricultural irrigation, detention basins, or for recreational use by community residents. Finally, the total habitat suitability scores and occurrence of Common Moorhens in each farm pond were used to verify the accuracy of the habitat-suitability assessment model for the Common Moorhen. The overall accuracy was 0.8, and the Kappa value was 0.60, which indicates that the model established in this study exhibited high credibility. To sum up, this is an applicable framework not only to assess the habitat suitability of farm ponds for Common Moorhens, but also to determine whether a particular location may

  9. Identification of multiple sites suitable for insertion of foreign genes in herpes simplex virus genomes.

    Science.gov (United States)

    Morimoto, Tomomi; Arii, Jun; Akashi, Hiroomi; Kawaguchi, Yasushi

    2009-03-01

    Information on sites in HSV genomes at which foreign gene(s) can be inserted without disrupting viral genes or affecting properties of the parental virus are important for basic research on HSV and development of HSV-based vectors for human therapy. The intergenic region between HSV-1 UL3 and UL4 genes has been reported to satisfy the requirements for such an insertion site. The UL3 and UL4 genes are oriented toward the intergenic region and, therefore, insertion of a foreign gene(s) into the region between the UL3 and UL4 polyadenylation signals should not disrupt any viral genes or transcriptional units. HSV-1 and HSV-2 each have more than 10 additional regions structurally similar to the intergenic region between UL3 and UL4. In the studies reported here, it has been demonstrated that insertion of a reporter gene expression cassette into several of the HSV-1 and HSV-2 intergenic regions has no effect on viral growth in cell culture or virulence in mice, suggesting that these multiple intergenic regions may be suitable HSV sites for insertion of foreign genes.

  10. Workshop material for state review of USNRC site suitability criteria for high-level radioactive waste repositories

    International Nuclear Information System (INIS)

    1977-08-01

    The Nuclear Regulatory Commission (NRC) is developing criteria on which to judge whether a proposed site for a geologic repository is suitable for disposal of high-level nuclear wastes. To aid in its analysis and assessment, NRC is planning three early independent reviews of the site suitability criteria development effort: a peer review by experts outside of NRC; a review by the National Academy of Sciences; and a review by State officials. This document has been prepared to aid workshop participants in understanding the Preliminary Site Suitability Criteria and to prepare them to contribute to an evaluation of those criteria

  11. Using a Geographic Information System to Assess Site Suitability for Managed Aquifer Recharge using Stormwater Capture

    Science.gov (United States)

    Teo, E. K.; Harmon, R. E.; Beganskas, S.; Young, K. S.; Fisher, A. T.; Weir, W. B.; Lozano, S.

    2015-12-01

    We are completing a regional analysis of Santa Cruz and northern Monterey Counties, CA, to assess the conditions amenable to managed aquifer recharge using stormwater runoff. Communities and water supply agencies across CA are struggling to mitigate the ongoing drought and to develop secure and sustainable water supplies to support long-term municipal, agricultural, environmental and other needs. Enhanced storage of groundwater is an important part of this effort in many basins. This work is especially timely because of the recently enacted "Sustainable Groundwater Management Act" (SGMA), which requires the development of groundwater sustainability agencies and implementation of basin management plans in coming decades. Our analysis focuses specifically on the distributed collection of stormwater runoff, a water source that has typically been treated as a nuisance or waste, from drainages having an area on the order of 40-160 hectares. The first part of this project is a geographic information system (GIS) analysis using surface and subsurface data sets. Developing complete and accurate datasets across the study region required considerable effort to locate, assemble, co-register, patch, and reconcile information from many sources and scales. We have complete spatial coverage for surface data, but subsurface data is more limited in lateral extent. Sites that are most suitable for distributed stormwater capture supporting MAR have high soil infiltration capacity, are well-connected to an underlying aquifer with good transmissive and storage properties, and have space to receive MAR. Additional considerations include method of infiltration, slope, and land use and access. Based on initial consideration of surface data and slope, 7% of the complete study region appears to be "suitable or highly suitable" for MAR (in the top third of the rating system), but there is considerable spatial heterogeneity based on the distribution of shallow soils and bedrock geology.

  12. A comparative study to identify a suitable model of ownership for Iran football pro league clubs

    Directory of Open Access Journals (Sweden)

    Saeed Amirnejad

    2018-01-01

    Full Text Available Today the government ownership of the professional football clubs is absolutely illogical view point. Most of sports clubs are conducted by private sector using different models of ownership all over the world. In Iran, government credits benefit was main reason that the professional sport was firstly developed by government firms and organizations. Therefore, the sports team ownership is without the professionalization standards. The present comparative study was to examine the different football club ownership structures of the top leagues and the current condition of Iran football pro league ownership and then present a suitable ownership structure of Iran football clubs to leave behind the government club ownership. Among the initial 120 scientific texts, the thirty two cases including papers, books and reports were found relevant to this study. We studied the ownership prominence and several football club models of ownership focused on stock listing model of ownership, private investor model of ownership, supporter trust model of ownership and Japan partnership model of ownership; theoretical concepts, empirical studies, main findings, strengths and weaknesses were covered in analysis procedure. According to various models of ownership in leagues and the models’ productivity in football clubs, each model of ownership considering national environmental, economic, social conditions has strengths and weaknesses. So, we cannot present a definite model of ownership for Iran football pro league clubs due to different micro-environments of Iran clubs. We need a big planning to provide a supporter-investor mixed model of ownership to Iranian clubs. Considering strengths and weaknesses in the models of ownership as well as the micro and macro environment of Iran football clubs, German model and Japan partnership model are offered as suitable ones to probable new model of ownership in Iran pro league clubs. Consequently, more studies are required

  13. Preclosure seismic hazards and their impact on site suitability of Yucca Mountain, Nevada

    International Nuclear Information System (INIS)

    Gibson, J.D.

    1992-01-01

    This paper presents an overview of the preclosure seismic hazards and the influence of these hazards on determining the suitability of Yucca Mountain as a national high-level nuclear-waste repository. Geologic data, engineering analyses, and regulatory guidelines must be examined collectively to assess this suitability. An environmental assessment for Yucca Mountain, written in 1986, compiled and evaluated the existing tectonic data and presented arguments to satisfy, in part, the regulatory requirements that must be met if the Yucca Mountain site is to become a national waste repository. Analyses have been performed in the past five years that better quantify the local seismic hazards and the possibility that these hazards could lead to release of radionuclides to the environment. The results from these analyses increase the confidence in the ability of Yucca Mountain and the facilities that may be built there to function satisfactorily in their role as a waste repository. Uncertainties remain, however, primarily in the input parameters and boundary conditions for the models that were used to complete the analyses. These models must be validated and uncertainties reduced before Yucca Mountain can qualify as a viable high-level nuclear waste repository

  14. Summary of climatic input for waste management site suitability criteria and state of progress

    International Nuclear Information System (INIS)

    Potter, G.L.

    1978-01-01

    Because groundwater movement can have important effects on buried nuclear wastes, hydrologists need to know if future climatic changes will influence the accuracy of groundwater flow calculations. Groundwater recharge (and therefore groundwater flow) depends on surface water balance. (Surface water balance equals precipitation less losses to evaporation, runoff, and storage.) To develop input data for modeling future climatic effects, we have made the following simplifying assumptions: (1) Climate (and therefore water balance) will behave in the future very much as it has in the past. (2) Groundwater recharge responds linearly to precipitation. (3) Future long-term climatic changes can be classified into groups or regimes that are similar to those of the past. Our current research is aimed at providing input data to the Waste Management Program's site suitability task. 16 figures, 1 table

  15. Workshops for state review of site suitability criteria for high-level radioactive waste repositories: analysis and recommendations

    International Nuclear Information System (INIS)

    1978-02-01

    The responses from various discussion groups on site suitability criteria for high-level radioactive waste repositories are presented. The consensus, principal concern, and minority opinion on each issue are given. The visual aids used in the workshop are included

  16. Identifying suitable substrates for high-quality graphene-based heterostructures

    Science.gov (United States)

    Banszerus, L.; Janssen, H.; Otto, M.; Epping, A.; Taniguchi, T.; Watanabe, K.; Beschoten, B.; Neumaier, D.; Stampfer, C.

    2017-06-01

    We report on a scanning confocal Raman spectroscopy study investigating the strain-uniformity and the overall strain and doping of high-quality chemical vapour deposited (CVD) graphene-based heterostuctures on a large number of different substrate materials, including hexagonal boron nitride (hBN), transition metal dichalcogenides, silicon, different oxides and nitrides, as well as polymers. By applying a hBN-assisted, contamination free, dry transfer process for CVD graphene, high-quality heterostructures with low doping densities and low strain variations are assembled. The Raman spectra of these pristine heterostructures are sensitive to substrate-induced doping and strain variations and are thus used to probe the suitability of the substrate material for potential high-quality graphene devices. We find that the flatness of the substrate material is a key figure for gaining, or preserving high-quality graphene.

  17. Can suitable candidates for levodopa/carbidopa intestinal gel therapy be identified using current evidence?

    Directory of Open Access Journals (Sweden)

    Maria José Catalán

    2017-09-01

    In recent years, strong evidence has supported the use of LCIG in treating motor fluctuations associated with APD, and several clinical studies provide emerging evidence for additional benefits of LCIG treatment in certain patients. This article provides an overview of the published literature on the benefits, limitations, and drawbacks of LCIG in relation to PD symptoms, the psychosocial impact of the disease, and the quality of life of patients, with the aim of determining candidates for whom treatment with LCIG would be beneficial. According to current evidence, patients with APD (defined as inability to achieve optimal control of the disease with conventional oral treatment, a relatively well-preserved cognitive-behavioral status, and good family/caregiver would count as suitable candidates for LCIG treatment. Contraindications in the opinion of the authors are severe dementia and active psychosis.

  18. Identifying applicants suitable to a career in nursing: a value-based approach to undergraduate selection.

    Science.gov (United States)

    Traynor, Marian; Galanouli, Despina; Roberts, Martin; Leonard, Lawrence; Gale, Thomas

    2017-06-01

    The aim of this study was to complement existing evidence on the suitability of Multiple Mini Interviews as a potential tool for the selection of nursing candidates on to a BSc (Hons) nursing programme. This study aimed to trial the Multiple Mini Interview approach to recruitment with a group of first year nursing students (already selected using traditional interviews). Cross-sectional validation study. This paper reports on the evaluation of the participants' detailed scores from the Multiple Mini Interview stations; their original interview scores and their end of year results. This study took place in March 2015. Scores from the seven Multiple Mini Interview stations were analysed to show the internal structure, reliability and generalizability of the stations. Original selection scores from interviews and in-course assessment were correlated with the MMI scores and variation by students' age, gender and disability status was explored. Reliability of the Multiple Mini Interview score was moderate (G = 0·52). The Multiple Mini Interview score provided better differentiation between more able students than did the original interview score but neither score was correlated with the module results. Multiple Mini Interview scores were positively associated with students' age but not their gender or disability status. The Multiple Mini Interview reported in this study offers a selection process that is based on the values and personal attributes regarded as desirable for a career in nursing and does not necessarily predict academic success. Its moderate reliability indicates the need for further improvement but it is capable of discriminating between candidates and shows little evidence of bias. © 2016 John Wiley & Sons Ltd.

  19. A GIS analysis of suitability for construction aggregate recycling sites using regional transportation network and population density features

    Science.gov (United States)

    Robinson, G.R.; Kapo, K.E.

    2004-01-01

    to transportation network and population distribution data. The models can be used on a regional scale to quickly map the relative site suitability for a RAP or RPCC aggregate recycling operation in a particular area based on transportation network and population parameters. The results can be used to identify general areas to be further evaluated on a site-specific basis using more detailed marketplace information. As transportation or population features change due to planning or actual development, the models can be easily revised to reflect these changes. ?? 2004 Elsevier B.V. All rights reserved.

  20. An integrated study of spatial multicriteria analysis and mathematical modelling for managed aquifer recharge site suitability mapping and site ranking at Northern Gaza coastal aquifer.

    Science.gov (United States)

    Rahman, Mohammad Azizur; Rusteberg, Bernd; Uddin, Mohammad Salah; Lutz, Annegret; Saada, Muath Abu; Sauter, Martin

    2013-07-30

    This paper describes an integrated approach of site suitability mapping and ranking of the most suitable sites, for the implementation of Managed Aquifer Recharge (MAR) projects, using spatial multicriteria decision analysis (SMCDA) techniques and mathematical modelling. The SMCDA procedure contains constraint mapping, site suitability analysis with criteria standardization and weighting, criteria overlay by analytical hierarchy process (AHP) combined with weighted linear combination (WLC) and ordered weighted averaging (OWA), and sensitivity analysis. The hydrogeological impacts of the selected most suitable sites were quantified by using groundwater flow and transport modelling techniques. Finally, ranking of the selected sites was done with the WLC method. The integrated approach is demonstrated by a case study in the coastal aquifer of North Gaza. Constraint mapping shows that 50% of the total study area is suitable for MAR implementation. About 25% of the total area is "very good" and 25% percent is "good" for MAR, according to the site suitability analysis. Six locations were selected and ranked against six representative decision criteria. Long term (year 2003 to year 2040) groundwater flow and transport simulations were performed to quantify the selected criteria under MAR project operation conditions at the selected sites. Finally, the suitability mapping and hydrogeological investigation recommends that the location of the existing infiltration ponds, constructed near the planned North Gaza Wastewater Treatment Plant (NGWWTP) is most suitable for MAR project implementation. This paper concludes that mathematical modelling should be combined with the SMCDA technique in order to select the best location for MAR project implementation. Besides MAR project implementation, the generalised approach can be applicable for any other water resources development project that deals with site selection and implementation. Copyright © 2013 Elsevier Ltd. All rights

  1. A tool for identifying potential Eucalyptus nitens seed orchard sites ...

    African Journals Online (AJOL)

    Shy seed production in orchards of Eucalyptus nitens is a major barrier to the deployment of genetic gain in South African plantations. A machine learning method was used to identify optimal sites for the establishment of E. nitens seed orchards within the plantation forestry landscape of the summer rainfall region of South ...

  2. Site suitability evaluation of an old operating landfill using AHP and GIS techniques and integrated hydrogeological and geophysical surveys.

    Science.gov (United States)

    Saatsaz, Masoud; Monsef, Iman; Rahmani, Mostafa; Ghods, Abdolreza

    2018-02-16

    Because of the outdated methods of common landfill selection, it is imperative to reevaluate the usage suitability. To assess the suitability of the existing waste landfill in Zanjan, Iran, we have used a combination of the analytical hierarchy process (AHP) and GIS techniques, along with fieldwork surveys. Four major criteria and 12 subcriteria were considered, and the AHP was applied to assign the relative importance weights of criteria and subcriteria to each other. Finally, a landfill suitability map was generated and ranked based on the final suitability scores. The results show that the unsuitable areas are around Zanjan, in the middle parts of the plain. By contrast, the most suitable areas are uncultivated areas, located mostly in the west, north, and south. The results also indicate that the present landfill is a highly suitable site. After desk studies, geoelectrical surveys and infiltration measurements were conducted to make the final decision. Double-ring permeability tests confirm the landfill is an acceptable site. The electrical sounding shows that the leachate plume has a width of about ~ 450 m, spreads to a depth of about ~ 55 m, and migrates towards the northeast. Considering the groundwater depth, dry climate, and a low infiltration rate of the landfill soils, it can be concluded that leachate plumes will not contaminate groundwater within this decade. The proposed method can be implemented to reevaluate the suitability of any old operating reservoir such as oil reservoirs, petrol filling stations, heavy industrial tanks, and landfills, containing liquid hazardous materials.

  3. Identifying suitable sanitary landfill locations in the state of Morelos, México, using a Geographic Information System

    Science.gov (United States)

    Marín, Luis E.; Torres, Vicente; Bolongaro, Andrea; Reyna, José A.; Pohle, O.; Hernández-Espriú, A.; Chavarría, Jerónimo; García-Barrios, R.; Tabla, Hugo Francisco Parra

    GIS is a powerful tool that may help to better manage natural resources. In this paper, we present a GIS model developed for the state of Morelos as an aid to determine whether a potential site, Loma de Mejia, met the Mexican Federal Guidelines. The Mexican Government has established federal guidelines for sanitary landfill site selection (NOM-083-SERMARNAT-2003). These guidelines were translated into a water-based Geographic Information System and applied to the state of Morelos, Mexico. For these examples, we used the SIGAM® (Sistema de Información Geográfico del Agua en México; a water-based GIS for Mexico) which has at least 60 layers from the National Water Commission (CONAGUA), the national mapping agency (INEGI; Instituto Nacional de Estadística, Geografía e Informática), NASA, and academic institutions. Results show that a GIS is a powerful tool that may allow federal, state and municipal policy makers to conduct an initial regional site reconnaissance rapidly. Once potential sites are selected, further characterization must be carried out in order to determine if proposed locations are suitable or not for a sanitary landfill. Based on the SIGAM© software, the Loma de Mejia would not comply with the Mexican Federal Guidelines.

  4. Review of the continued suitability of the dumping site for radioactive waste in the North-East Atlantic

    International Nuclear Information System (INIS)

    1980-04-01

    Under the terms of the Decision of the OECD Council establishing a Multilateral Consultation and Surveillance Mechanism for Sea Dumping of Radioactive Waste, NEA is requested to assess, in consultation with the Environment Committee, the suitability of dumping sites proposed by the national authorities of Participating countries and to keep under review those previously considered suitable. Since 1974 radioactive waste sea dumping operations have been carried out in a single site located in the North-East Atlantic region. To fulfil the objectives of the Council Decision, an international group of oceanographic and radiation protection experts was convened by NEA in November 1979 to undertake a review of the continued suitability of the dumping site, taking into account the relevant provisions of the London Dumping Convention and the IAEA Definition and Recommendations for the purposes of the Convention. The results of the review are contained in this Report. The Steering Committee for Nuclear Energy confirmed in April 1980 that, on the basis of the review, the existing site was suitable for continued dumping of radioactive waste for the next five years, under the conditions specified by the Group of Experts in their conclusions and recommendations. At the same time, the Steering Committee for Nuclear Energy agreed on the need for developing a co-ordinated site-specific scientific programme to increase current knowledge of the processes controlling the transfert of radionuclides in the marine environment, so that future assessments can be based on more accurate and comprehensive scientific data

  5. Geologic setting of the proposed West Flank Forge Site, California: Suitability for EGS research and development

    Science.gov (United States)

    Sabin, Andrew; Blake, Kelly; Lazaro, Mike; Blankenship, Douglas; Kennedy, Mack; McCullough, Jess; DeOreo, S.B.; Hickman, Stephen H.; Glen, Jonathan; Kaven, Joern; Williams, Colin F.; Phelps, Geoffrey; Faulds, James E.; Hinz, Nicholas H.; Calvin, Wendy M.; Siler, Drew; Robertson-Tait, Ann

    2017-01-01

    The proposed West Flank FORGE site is within the China Lake Naval Air Weapons Station (NAWS), China Lake, CA. The West Flank is west of the Coso geothermal field, an area of China Lake NAWS dominated by the Quaternary Coso volcanic field largely comprised of rhyolite domes and their volcaniclastic and epiclastic horizons. The largest dome flow complex, Sugarloaf Mountain, marks the northwestern margin of the geothermal field. The West Flank is situated due west of Sugarloaf. The geologic setting of the West Flank was determined from one deep well (83-11) drilled as a potential production hole in 2009. The bottom-hole temperature (BHT) of well 83-11 approaches 600 oF (315˚C), but flow tests demonstrate very low, non-commercial permeabilities. With the exception of the upper 600 feet of volcaniclastic alluvium, well 83-11 is completed in granitic basement. The West Flank possesses the primary attributes of a FORGE site: non-commercial permeability (geothermal fieldThe Coso Mountains host the Coso volcanic field and are within a right-releasing stepover between the dextral Airport Lake (ALF) and Little Lake fault zones (LLFZ) and the Wild Horse Mesa and Owens Valley faults. Two distinct fault populations have been identified at Coso: WNW-trending and antithetical, NE-trending strike-slip faults and N- to NNE-trending normal faults. These faults are both high permeability drilling targets at depth within the main (productive) geothermal field and they locally segment the field into distinct hydrothermal regimes. The West Flank may be segmented from the rest of the field by one such northerly trending fault. The overall minimum principal stress orientation in the main geothermal field varies from 103˚ to 108˚; however, the minimum horizontal principal stress in 83-11 is rotated to 081˚.

  6. Application of the Analytic Hierarchy Process to Identify the Most Suitable Lessor of Freight Car Finance Leasing

    Directory of Open Access Journals (Sweden)

    Lei Lei

    2017-01-01

    Full Text Available Finance leasing (also “equipment leasing” saves the cost, improves the efficiency and benefit, larger the manufacture supply channels, which is an optimal solution for equipment supply with uncertain freight demand. The article collects the definitions of Finance Leasing based on the four pillars theory of finance leasing, also divides the lessors in Freight Car finance leasing into three categories according to their major business: manufacturers, banks as the representative financial institutions, firms that specialized in finance leasing. To identify the most suitable lessor for each railway department, an indicator system is built and operated by Yaahp (a software based on Analytic Hierarchy Process.

  7. Identifying potential kidney donors using social networking web sites.

    Science.gov (United States)

    Chang, Alexander; Anderson, Emily E; Turner, Hang T; Shoham, David; Hou, Susan H; Grams, Morgan

    2013-01-01

    Social networking sites like Facebook may be a powerful tool for increasing rates of live kidney donation. They allow for wide dissemination of information and discussion and could lessen anxiety associated with a face-to-face request for donation. However, sparse data exist on the use of social media for this purpose. We searched Facebook, the most popular social networking site, for publicly available English-language pages seeking kidney donors for a specific individual, abstracting information on the potential recipient, characteristics of the page itself, and whether potential donors were tested. In the 91 pages meeting inclusion criteria, the mean age of potential recipients was 37 (range: 2-69); 88% were US residents. Other posted information included the individual's photograph (76%), blood type (64%), cause of kidney disease (43%), and location (71%). Thirty-two percent of pages reported having potential donors tested, and 10% reported receiving a live-donor kidney transplant. Those reporting donor testing shared more potential recipient characteristics, provided more information about transplantation, and had higher page traffic. Facebook is already being used to identify potential kidney donors. Future studies should focus on how to safely, ethically, and effectively use social networking sites to inform potential donors and potentially expand live kidney donation. © 2013 John Wiley & Sons A/S.

  8. Assessment of Managed Aquifer Recharge Site Suitability Using a GIS and Modeling.

    Science.gov (United States)

    Russo, Tess A; Fisher, Andrew T; Lockwood, Brian S

    2015-01-01

    We completed a two-step regional analysis of a coastal groundwater basin to (1) assess regional suitability for managed aquifer recharge (MAR), and (2) quantify the relative impact of MAR activities on groundwater levels and sea water intrusion. The first step comprised an analysis of surface and subsurface hydrologic properties and conditions, using a geographic information system (GIS). Surface and subsurface data coverages were compiled, georeferenced, reclassified, and integrated (including novel approaches for combining related datasets) to derive a spatial distribution of MAR suitability values. In the second step, results from the GIS analysis were used with a regional groundwater model to assess the hydrologic impact of potential MAR placement and operating scenarios. For the region evaluated in this study, the Pajaro Valley Groundwater Basin, California, GIS results suggest that about 7% (15 km2) of the basin may be highly suitable for MAR. Modeling suggests that simulated MAR projects placed near the coast help to reduce sea water intrusion more rapidly, but these projects also result in increased groundwater flows to the ocean. In contrast, projects placed farther inland result in more long-term reduction in sea water intrusion and less groundwater flowing to the ocean. This work shows how combined GIS analysis and modeling can assist with regional water supply planning, including evaluation of options for enhancing groundwater resources. © 2014, National Ground Water Association.

  9. Catalytic site identification—a web server to identify catalytic site structural matches throughout PDB

    Science.gov (United States)

    Kirshner, Daniel A.; Nilmeier, Jerome P.; Lightstone, Felice C.

    2013-01-01

    The catalytic site identification web server provides the innovative capability to find structural matches to a user-specified catalytic site among all Protein Data Bank proteins rapidly (in less than a minute). The server also can examine a user-specified protein structure or model to identify structural matches to a library of catalytic sites. Finally, the server provides a database of pre-calculated matches between all Protein Data Bank proteins and the library of catalytic sites. The database has been used to derive a set of hypothesized novel enzymatic function annotations. In all cases, matches and putative binding sites (protein structure and surfaces) can be visualized interactively online. The website can be accessed at http://catsid.llnl.gov. PMID:23680785

  10. Identifying high dose activities in industrial site radiography

    International Nuclear Information System (INIS)

    Heaton, B.

    2000-01-01

    Although the radiation doses received by industrial radiographers in the UK have progressively fallen over the last few years, with most now receiving less than 1 mSv/y, a few still receive, relative to the rest, much higher doses. As a percentage of all radiographers the number stays surprisingly constant from year to year. This paper describes a survey to identify the work causing these doses and suggest possible solutions. The UK Central Index of Dose Information was interrogated to identify the industrial radiography companies having staff (not necessarily the same person) with doses of greater than 5mSv/y in the last three years for which information was available. This was 15 in total. The people on the staff receiving these doses were identified and a questionnaire sent to the companies concerned requesting information about their work. A general questionnaire about the operation of the company was also included. With the agreement of the company these questionnaires were followed up by a visit to the company to interviews a number of the management and the radiographers if available. Both groups were generally very open about their problems and every discussion had a positive outcome. Several areas of work/reasons for the doses have been identified. These are: pipeline radiography, ultra sound radiographers working on nuclear reactors, complex plant work often with several teams in the area, inability to retreat from the wind out equipment due to height or access problems, site pressure to not follow the best practices and a lack of appreciation when a dose was being received or, alternatively, carelessness. Some o these problem areas are very difficult to resolve. However ways in which the Health and Safety can help influence the doses have been identified together with practical suggestions radiographers could adopt. These will be reported. (author)

  11. A novel diagnostic protocol to identify patients suitable for discharge after a single high-sensitivity troponin

    Science.gov (United States)

    Carlton, Edward W; Cullen, Louise; Than, Martin; Gamble, James; Khattab, Ahmed; Greaves, Kim

    2015-01-01

    Objective To establish whether a novel accelerated diagnostic protocol (ADP) for suspected acute coronary syndrome (ACS) could successfully identify low-risk patients suitable for discharge after a single high-sensitivity troponin T (hs-cTnT) taken at presentation to the emergency department. We also compared the diagnostic accuracy of this ADP with strategies using initial undetectable hs-cTnT. Methods This prospective observational study evaluated the ability of the Triage Rule-out Using high-Sensitivity Troponin (TRUST) ADP to identify low-risk patients with suspected ACS. The ADP incorporated a single presentation hs-cTnT of <14 ng/L, a non-ischaemic ECG and a modified Goldman risk score. Diagnostic performance of the ADP was compared with the detection limit cut-offs of hs-cTnT (<5 ng/L and <3 ng/L). The primary end point was fatal/non-fatal acute myocardial infarction (AMI) within 30 days. Results 960 participants were recruited, mean age 58.0 years, 80 (8.3%) had an AMI. The TRUST ADP classified 382 (39.8%) as low-risk with a sensitivity for identifying AMI of 98.8% (95% CI 92.5% to 99.9%). hs-cTnT detection limits (<5 ng/L and <3 ng/L) had a sensitivity of 100% (94.3 to 100) and 100% (94.4 to 100), respectively. The TRUST ADP identified more patients suitable for early discharge at 39.8% vs 29.3% (<5 ng/L) and 7.9% (<3 ng/L) (p<0.001) with a lower false-positive rate for AMI detection; specificity 43.3% (95% CI 42.7% to 43.4%) vs 32.0% (95% CI 31.5% to 32.0%) and 8.6% (95% CI 8.1% to 8.6%), respectively. Conclusions The TRUST ADP, which incorporates structured risk-assessment and a single presentation hs-cTnT blood draw, has potential to allow early discharge in 40% of patients with suspected ACS and has greater clinical utility than undetectable hs-cTnT strategies. Trial registration number ISRCTN No. 21109279. PMID:25691511

  12. Suitability analysis for rice growing sites using a multicriteria evaluation and GIS approach in great Mwea region, Kenya.

    Science.gov (United States)

    Kihoro, Joseph; Bosco, Njoroge J; Murage, Hunja

    2013-12-01

    Land suitability analysis is a prerequisite to achieving optimum utilization of the available land resources. Lack of knowledge on best combination of factors that suit production of rice has contributed to the low production. The aim of this study was to develop a suitability map for rice crop based on physical and climatic factors of production using a Multi-Criteria Evaluation (MCE) & GIS approach. The study was carried out in Kirinyaga, Embu and Mberee counties in Kenya. Biophysical variables of soil, climate and topography were considered for suitability analysis. All data were stored in ArcGIS 9.3 environment and the factor maps were generated. For MCE, Pairwise Comparison Matrix was applied and the suitable areas for rice crop were generated and graduated. The current land cover map of the area was developed from a scanned survey map of the rice growing areas. According to the present land cover map, the rice cultivated area was 13,369 ha. Finally, we overlaid the land cover map with the suitability map to identify variances between the present and potential land use. The crop-land evaluation results of the present study showed that, 75% of total area currently being used was under highly suitable areas and 25% was under moderately suitable areas. The results showed that the potential area for rice growing is 86,364 ha and out of this only 12% is under rice cultivation. This research provided information at local level that could be used by farmers to select cropping patterns and suitability.

  13. Excess Lead-210 and Plutonium-239+240: Two suitable radiogenic soil erosion tracers for mountain grassland sites.

    Science.gov (United States)

    Meusburger, K; Porto, P; Mabit, L; La Spada, C; Arata, L; Alewell, C

    2018-01-01

    The expected growing population and challenges associated with globalisation will increase local food and feed demands and enhance the pressure on local and regional upland soil resources. In light of these potential future developments it is necessary to define sustainable land use and tolerable soil loss rates with methods applicable and adapted to mountainous areas. Fallout-radionuclides (FRNs) are proven techniques to increase our knowledge about the status and resilience of agro-ecosystems. However, the use of the Caesium-137 ( 137 Cs) method is complicated in the European Alps due to its heterogeneous input and the timing of the Chernobyl fallout, which occurred during a few single rain events on partly snow covered ground. Other radioisotopic techniques have been proposed to overcome these limitations. The objective of this study is to evaluate the suitability of excess Lead-210 ( 210 Pb ex ) and Plutonium-239+240 ( 239+240 Pu) as soil erosion tracers for three different grassland management types at the steep slopes (slope angles between 35 and 38°) located in the Central Swiss Alps. All three FRNs identified pastures as having the highest mean (± standard deviation) net soil loss of -6.7 ± 1.1, -9.8 ± 6.8 and -7.0 ± 5.2 Mg ha -1 yr -1 for 137 Cs, 210 Pb ex and 239+240 Pu, respectively. A mean soil loss of -5.7 ± 1.5, -5.2 ± 1.5 and-5.6 ± 2.1 was assessed for hayfields and the lowest rates were established for pastures with dwarf-shrubs (-5.2 ± 2.5, -4.5 ± 2.5 and -3.3 ± 2.4 Mg ha -1 yr -1 for 137 Cs, 210 Pb ex and 239+240 Pu, respectively). These rates, evaluated at sites with an elevated soil erosion risk exceed the respective soil production rates. Among the three FRN methods used, 239+240 Pu appears as the most promising tracer in terms of measurement uncertainty and reduced small scale variability (CV of 13%). Despite a higher level of uncertainty, 210 Pb ex produced comparable results, with a wide range of erosion rates sensitive to changes

  14. Geologic setting of the proposed Fallon FORGE Site, Nevada: Suitability for EGS research and development

    Science.gov (United States)

    Faulds, James E.; Blankenship, Douglas; Hinz, Nicholas H.; Sabin, Andrew; Nordquist, Josh; Hickman, Stephen H.; Glen, Jonathan; Kennedy, Mack; Siler, Drew; Robinson-Tait, Ann; Williams, Colin F.; Drakos, Peter; Calvin, Wendy M.

    2015-01-01

    The proposed Fallon FORGE site lies within and adjacent to the Naval Air Station Fallon (NASF) directly southeast of the town of Fallon, Nevada, within the large basin of the Carson Sink in west-central Nevada. The site is located on two parcels that include land owned by the NASF and leased and owned by Ormat Nevada, Inc. The Carson Sink in the vicinity of the Fallon site is covered by Quaternary deposits, including alluvial fan, eolian, and lacustrine sediments. Four wells penetrate the entire Neogene section and bottom in Mesozoic basement. Late Miocene to Quaternary basin-fill sediments are 0.5 to >1 km thick and overlie Oligocene-Miocene volcanic and lesser sedimentary rocks. The volcanic section is 0.5 to 1.0 km thick and dominated by Miocene mafic lavas. The Neogene section rests nonconformably on heterogeneous Mesozoic basement, which consists of Triassic-Jurassic metamorphic rocks intruded by Cretaceous granitic plutons. The structural framework is dominated by a gently west-tilted half graben cut by moderately to steeply dipping N- to NNEstriking normal faults that dip both east and west. Quaternary faults have not been observed within the proposed FORGE site. Fallon was selected for a potential FORGE site due to its extensional tectonic setting, abundance of available data, existing infrastructure, and documented temperatures, permeability, and lithologic composition of potential reservoirs that fall within the ranges specified by DOE for FORGE. Since the early 1970s, more than 45 wells have been drilled for geothermal exploration within the area. Four exploration wells within the FORGE site are available for use in the project. Several additional wells are available for monitoring outside the central FORGE site within the NASF and Ormat lease area, including numerous temperature gradient holes. There is an existing, ten-station micro-seismic earthquake (MEQ) array that has been collecting data since 2001; the MEQ array can be expanded to encompass the

  15. Identifying Key Factors Relevant for Base Camp Siting

    Science.gov (United States)

    2017-12-01

    centers. 3.2.6.3 Religious and historical sites Respecting sacred sites helps build rapport with the host nation. 3.2.6.4 Local infrastructure...churches, mosques, national libraries, hospitals, cemeteries, historical ruins, religious sites, cultural areas, and other protected sites...controlled and protected wells. • Electricity: town engineer • Academic: government and religious leaders • Trash: private business (local

  16. A COMBINED FUZZY MCDM APPROACH FOR IDENTIFYING THE SUITABLE LANDS FOR URBAN DEVELOPMENT: AN EXAMPLE FROM BANDAR ABBS, IRAN

    Directory of Open Access Journals (Sweden)

    Mohsen Dadras

    2014-01-01

    Full Text Available This study aims at identifying the suitable lands for urban dev elopment in Bandar Abbas city based on its real world use regarding specific crite ria and sub-criteria. The city of Bandar Abbas is considered as the most important commer cial and economic city of Iran. It is also considered as one of the major cities of Iran which has played a pivotal role in the country's development and progress in recen t years especially after the end of Iran-Iraq war owing to its embracing the country's m ain commercial ports. This process has caused the immigration rate into the city to rise significantly over the past 20 years. Thus, the development of the city is meanwhile c onsidered as a high priority. Bandar Abbas city does not have a rich capacity for g rowth and development due to its special geographical situation being located in coastal border. Among the limitations placed in the city's development way, natural limit ations (heights and sea shore in the northern and southern parts of the city and struc tural limitations (military centers in the east and west sides of the city may be referred . Therefore, identifying the suitable lands for urban development within Bandar Abbas city l imits is becoming an essential priority. Therefore, d ifferent quantitative and quali tative criteria have been studied in order to select and identify these lands. The struct ures of qualitative criteria for most parts involve ambiguities and vagueness. This leads us to use Fuzzy logic in this study as a natural method for determining the solutions fo r problems of Multi- criteria decision making (MCDM. In the current research, a com bination of MCDM methods has been presented for analysis. To assignee weights of the criteria Fuzzy AHP (analytic hierarchy process is used for land selection and Fuzzy TOPSIS (method for order priority by similarity to ideal solution is utilized to choose the alternative that is the most appropriate through these criteria weights. The

  17. PWV, Temperature and Wind Statistics at Sites Suitable For mm and Sub-mm Wavelengths Astronomy

    Science.gov (United States)

    Otarola, Angel; Travouillon, Tony; De Breuck, Carlos; Radford, Simon; Matsushita, Satoki; Pérez-Beaupuits, Juan P.

    2018-01-01

    Atmospheric water vapor is the main limiting factor of atmospheric transparency in the mm and sub-mm wavelength spectral windows. Thus, dry sites are needed for the installation and successful operation of radio astronomy observatories exploiting those spectral windows. Other parameters that play an important role in the mechanical response of radio telescopes exposed to the environmental conditions are: temperature, and in particular temperature gradients that induce thermal deformation of mechanical structures, as well as wind magnitude that induce pointing jitter affecting this way the required accuracy in the ability to point to a cosmic source during the observations. Temperature and wind are variables of special consideration when planning the installation and operations of large aperture radio telescopes. This work summarizes the statistics of precipitable water vapor (PWV), temperature and wind monitored at sites by the costal mountain range, as well as on t he west slope of the Andes mountain range in the region of Antofagasta, Chile. This information could prove useful for the planning of the Atacama Large-Aperture Submm/mm Telescope (AtLast).

  18. Draft environmental impact statement. High-level waste repository site suitability criteria

    International Nuclear Information System (INIS)

    1978-01-01

    The purpose of HLWRSSC is to present guidelines which will help in the development of safe waste management schemes. Current regulations require solidification of all high-level waste within 5 years of their generation and transfer to a Federal waste repository within 10 years. Development of the proposed HLWRSSC is part of the overall NRC program to close the ''back end'' of the commercial LWR fuel cycle. In this document, the need for the HLWRSSC is reviewed, and the national energy policy, the need for electrical energy, and the nuclear fuel cycle are discussed. Considerations for HLWRSSC are presented, including the nature of the repository, important site-related factors, and radiological risk assessment methodology. Radiological and nonradiological environment impacts associated with the HLWRSSC are defined. Alternatives to the criteria are presented, and the cost-benefit-risk evaluation is reviewed

  19. Workshops for state review of site suitability criteria for high-level radioactive waste repositories: analysis and recommendations

    International Nuclear Information System (INIS)

    1978-02-01

    The purpose of this report is to present the views and recommendations of invited State officials and legislators participating in a workshop concerned with preliminary site suitability criteria for high level radioactive waste repositories. The workshops were open to the public and were conducted by the U. S. Nuclear Regulatory Commission (NRC) during September 1977 in three regional locations across the United States. This contractor report is the second of two reports and consolidates the discussion by State officials on the role of a State in siting a repository, NRC's waste management program, the transportation of high level wastes, the number and location of repositories and concerns with the socio-economic impacts of siting a repository in a community. The recommendations to the NRC can be categorized into four areas. These were: (1) general recommendations, (2) procedural recommendations, (3) recommendations for improving communications, and (4) specific recommendations on the preliminary siting criteria. The recommendations emphasized the need for early State involvement in the siting process, the need for an impacted State to assess repository operations, the need for early solution of waste transportation concerns, and the requirement that any repository developed insure the protection of the public health and safety as its most important characteristic. Other participant recommendations are included in the body of the report

  20. Discussion of quantitative assessment index system of suitability of the site for geological disposal repository of high-level radioactive waste

    International Nuclear Information System (INIS)

    Su Rui; Wang Ju

    2014-01-01

    Site selection and suitability assessment of site are one of important tasks of research and development of geological disposal engineering for high-level radioactive waste (HLW). Quantitative assessment of suitability of the site is based on the scientific, reasonable and operational index system. The discussion of index screening of quantitative assessment of suitability of the site is conducted. Principle of index screening is presented and index systems are established for different stages of site selection, including planning stage of site selection, region or area investigation stage, site characterization and site confirmation stage. But the considerations are taken of the complexity of site selection of geological disposal engineering for HLW and itself development of quantitative assessment method, so improvement of the index systems presented above is needed in the further. (authors)

  1. The meaning and classification of tattoos in the context of their suitability to identify corpses of unknown identity.

    Science.gov (United States)

    Sadowski, Wojciech A; Borowska-Solonynko, Aleksandra B

    2017-01-01

    To present the most popular types of tattoos, their meaning and classification, and to assess the suitability of different forms of tattoos in the process of identification of corpses of unknown identity. The tattoos found on 729 cadavers who underwent post mortem examinations at the Department of Forensic Medicine in Warsaw in the years 2012-2015 were analyzed. The tattoos were photographed and identified in terms of their meaning domain and classified into groups. Tattoos belonging to all groups were found, according to the most popular tattoo classification, which is based on their nature and includes: criminal and prison tattoos (defining the prison hierarchy, criminal profession as well as intentions and goals, erotic tattoos, environmental, penitentiary), military and artistic. The novel classification, focusing on the utility of certain kinds of tattoos for identyfying corpses of unknown identity, was also developed. According to the above mentioned classification the following kinds of tattoos are distinguished: individual (artistic), group (e.g. penitentiary - indicating the fact of being imprisoned in a penitentiary institution or belonging to a "prison kites" subculture, or presenting criminal profession; group confined tattoo (indicating a staying in a specific penitentiary institution), group tattoo with individual data (indicating the fact of staying in a penitentiary institution as well as dates of imprisonment), and others (e.g. names of relatives, military tattoo, etc.). Analysis of individual types of tattoo can accelerate the process of identification of the cadavers. The proposed classification allows to quickly determine whether a particular tattoo can be helpful in initial individual identification (in the case of individual tattoos) or whether it can be used to reduce the group of people considered (in cases of different types of group tattoos).

  2. Workshops for state review of site suitability criteria for high-level radioactive waste repositories. Discussion Group reports

    International Nuclear Information System (INIS)

    1977-10-01

    The NRC Waste Management Program and the Office of State Programs held three regional workshops to solicit ideas from State executives and legislators on the siting and licensing procedures for high level waste repositories and to solicit comments on the NRC preliminary site suitability criteria. The workshops were held in Denver, Colorado; New Orleans, Louisiana; and Philadelphia, Pennsylvania during the period 19-30 September 1977. The reports from these workshops are contained herein. The workshops were attended by 170 invited State executives and legislators from 46 states. In addition, there were over 80 observers from diverse backgrounds including the general public, government, industry, professional consultants and university faculty. The workshops were announced in the Federal Register on September 1, 1977

  3. Application of a GIS Multi-Criteria Decision Analysis for the Identification of Intrinsic Suitable Sites in Costa Rica for the Application of Managed Aquifer Recharge (MAR through Spreading Methods

    Directory of Open Access Journals (Sweden)

    José Pablo Bonilla Valverde

    2016-09-01

    Full Text Available Costa Rica’s annual mean precipitation is above 3300 mm, but this precipitation is not evenly distributed in time or space, producing clear differentiated wet and dry seasons in most of the country. Droughts are also common phenomena which greatly affect the availability of water resources. Managed aquifer recharge (MAR schemes are being taken into consideration to enhance the underground water storage capacity of the country. The present study constitutes the first assessment for the identification of suitable sites for the implementation of MAR technology spreading methods (SM in Costa Rica. The suitable sites are identified by means of a geographic information system multi-criteria decision analysis (GIS-MCDA based on four criteria: hydrogeological aptitude, terrain slope, top soil texture and drainage network density. Four steps are performed in order to identify these sites: problem definition, screening for suitable areas, suitability mapping, and sensitivity analysis. The suitability map was divided in two zones after the screening: suitable and unsuitable, the first zone was further divided in five classes according to the weighted linear combination (WLC ranking. The results indicate that 61% of the country is suitable for conducting SM. This map is a tool for future implementation of MAR techniques in the country.

  4. Screening and assessment of solidification/stabilization amendments suitable for soils of lead-acid battery contaminated site.

    Science.gov (United States)

    Zhang, Zhuo; Guo, Guanlin; Teng, Yanguo; Wang, Jinsheng; Rhee, Jae Seong; Wang, Sen; Li, Fasheng

    2015-05-15

    Lead exposure via ingestion of soil and dust generally occurs at lead-acid battery manufacturing and recycling sites. Screening solidification/stabilization (S/S) amendments suitable for lead contaminated soil in an abandoned lead-acid battery factory site was conducted based on its chemical forms and environmental risks. Twelve amendments were used to immobilize the Pb in soil and assess the solidification/stabilization efficiency by toxicity leaching tests. The results indicated that three amendments, KH₂PO₄ (KP), KH₂PO₄:oyster shell power=1:1 (by mass ratio; SPP), and KH₂PO₄:sintered magnesia=1:1 (by mass ratio; KPM) had higher remediation efficiencies that led to a 92% reduction in leachable Pb with the addition of 5% amendments, while the acid soluble fraction of Pb (AS-Pb) decreased by 41-46% and the residual fraction (RS-Pb) increased by 16-25%. The S/S costs of the three selected amendments KP, SPP, and KPM could be controlled to $22.3 per ton of soil when the Pb concentration in soil ranged from 2000 to 3000 mg/kg. The results of this study demonstrated that KP, SPP, and KPM can effectively decrease bioavailability of Pb. These findings could provide basis for decision-making of S/S remediation of lead-acid battery contaminated sites. Copyright © 2015 Elsevier B.V. All rights reserved.

  5. Solid Waste Management in Greater Shillong Planning Area (GSPA) Using Spatial Multi-Criteria Decision Analysis for Site Suitability Assessment

    Science.gov (United States)

    Mipun, B. S.; Hazarika, R.; Mondal, M.; Mukhopadhyay, S.

    2015-04-01

    In Shillong city the existing solid waste management system is mobile waste bins (72%). About 12 percent burn the waste generated by them. Door to door collection is about 5 percent. Over 2 percent households throw the wastes in the open space. Another 9 percent households throw their wastes into the waste bins located in the neighbourhood. The local headman takes care about half of the household's wastes, while Municipality takes care about 34 percent households. About 10 percent households are ignorant about the collection and disposal of wastes. Some NGO's takes care about 5 percent household's wastes. Awareness about segregation of waste into organic and non-bio degradable waste is 64 percent and a significant numbers do the segregation. In Shillong Municipality Board (SMB) area collects 45.91% (78.42 MT) waste, outside SMB area collection is 32.61% (45.99 MT) and entire GSPA the percentage of garbage collected is 41percent. The only dumping ground in GSPA is Marten, Mawiong, and the capacity to hold garbage is decreasing due to limited landfill. The sanitary landfill site is 5.0 acres that it is not enough to meet the demand. Out of he total area 170.69 sq. km. (GSPA) only 25.67% is most suitable and 18.58% is unsuitable to set up a new landfill area. Eastern part of the GSPA, is most suitable, which fulfils the entire criterion adopted in this study. In this the best-stated criterion are land cover (vacant space), slope (2000m) and elevation (1300-1500m). The eastern part of the GSPA is most suitable landfill location.

  6. Suitability Assessment of X-Band Satellite SAR Data for Geotechnical Monitoring of Site Scale Slow Moving Landslides

    Directory of Open Access Journals (Sweden)

    Guadalupe Bru

    2018-06-01

    Full Text Available This work addresses the suitability of using X-band Synthetic Aperture Radar (SAR data for operational geotechnical monitoring of site scale slow moving landslides, affecting urban areas and infrastructures. The scale of these studies requires high resolution data. We propose a procedure for the practical use of SAR data in geotechnical landslides campaigns, that includes an appropriate dataset selection taking into account the scenario characteristics, a visibility analysis, and considerations when comparing advanced differential SAR interferometry (A-DInSAR results with other monitoring techniques. We have determined that Sentinel-2 satellite optical images are suited for performing high resolution land cover classifications, which results in the achievement of qualitative visibility maps. We also concluded that A-DInSAR is a very powerful and versatile tool for detailed scale landslide monitoring, although in combination with other instrumentation techniques.

  7. Site suitability for riverbed filtration system in Tanah Merah, Kelantan-A physical model study for turbidity removal

    Science.gov (United States)

    Ghani, Mastura; Adlan, Mohd Nordin; Kamal, Nurul Hana Mokhtar; Aziz, Hamidi Abdul

    2017-10-01

    A laboratory physical model study on riverbed filtration (RBeF) was conducted to investigate site suitability of soil from Tanah Merah, Kelantan for RBeF. Soil samples were collected and transported to the Geotechnical Engineering Laboratory, Universiti Sains Malaysia for sieve analysis and hydraulic conductivity tests. A physical model was fabricated with gravel packs laid at the bottom of it to cover the screen and then soil sample were placed above gravel pack for 30 cm depth. River water samples from Lubok Buntar, Kedah were used to simulate the effectiveness of RBeF for turbidity removal. Turbidity readings were tested at the inlet and outlet of the filter with specified flow rate. Results from soil characterization show that the soil samples were classified as poorly graded sand with hydraulic conductivity ranged from 7.95 x 10-3 to 6.61 x 10-2 cm/s. Turbidity removal ranged from 44.91% - 92.75% based on the turbidity of water samples before filtration in the range of 33.1-161 NTU. The turbidity of water samples after RBeF could be enhanced up to 2.53 NTU. River water samples with higher turbidity of more than 160 NTU could only reach 50% or less removal by the physical model. Flow rates of the RBeF were in the range of 0.11-1.61 L/min while flow rates at the inlet were set up between 2-4 L/min. Based on the result of soil classification, Tanah Merah site is suitable for RBeF whereas result from physical model study suggested that 30 cm depth of filter media is not sufficient to be used if river water turbidity is higher.

  8. Integration of Remote Sensing and other public GIS data source to identify suitable zones for groundwater exploitation by manual drilling

    Science.gov (United States)

    Fussi, Fabio; Fava, Francesco; Di Mauro, Biagio; Bonomi, Tullia; Fumagalli, Letizia; DI Leo, Margherita; Hamidou Kane, Cheik; Faye, Gayane; Niang, Magatte; Wade, Souleye; Hamidou, Barry; Colombo, Roberto

    2015-04-01

    In several countries of the world the situation of water supply is still critical, far from the international target defined by United Nations for 2015 (Millenium Development Goals) and producing a huge impact on health and living condition of the population. Manual drilling (it means techniques to drill boreholes for water using human or animal power) is well known and practiced for centuries in many countries. In recent years, it has been considered a potential strategy to increase water access in poor countries and has raised the attention of national governments and international organizations. Manual drilling is applicable only where hydrogeological context is suitable, according to the following conditions: thick layers of unconsolidated sediments and shallow water table. Mapping of zones with suitable hydrogeological context has been carried out in several countries in Africa, but the results have evident limitations; previous methods are based on existing direct data and qualitative experience, leading to unreliable interpretation when direct data are limited. This research aims to develop a methodology to estimate shallow hydrogeological features and asses the distribution of suitable zones for manual drilling through the integration of indirect information obtained from remote sensing and other existing source of data. The research is carried out in two different study areas, in Senegal and Guinea (Western Africa), with semi-arid climate, moderate vegetation cover, unconsolidated sandy and clay deposits overlaying sedimentary and igneous rocks A set of variables have been obtained through processing of three categories of data, listed below: - geology, geomorphology, soil and land cover, obtained from existing thematic maps; - vegetation phenology, apparent thermal inertia, and soil moisture, obtained from analysis of multitemporal optical (MOD13Q1), thermal (MOD11A1), and radar (ASAR) remotely sensed data: -morphometric parameters, obtained from public

  9. Methods and systems for identifying ligand-protein binding sites

    KAUST Repository

    Gao, Xin

    2016-05-06

    The invention provides a novel integrated structure and system-based approach for drug target prediction that enables the large-scale discovery of new targets for existing drugs Novel computer-readable storage media and computer systems are also provided. Methods and systems of the invention use novel sequence order-independent structure alignment, hierarchical clustering, and probabilistic sequence similarity techniques to construct a probabilistic pocket ensemble (PPE) that captures even promiscuous structural features of different binding sites for a drug on known targets. The drug\\'s PPE is combined with an approximation of the drug delivery profile to facilitate large-scale prediction of novel drug- protein interactions with several applications to biological research and drug development.

  10. Suitability analysis of wind energy development on brownfields, landfills and industrial sites in the city of Chicago

    Science.gov (United States)

    Fyodorova, Valeryia A.

    In 2011 renewable energy generated only about 5% of total U.S. electricity and 3% came from wind power. Wind power is the oldest and fastest growing renewable energy, and U.S. Department of Energy (DOE) anticipates that by 2030 the potential of the U.S. to generate wind power will rise up to 20% (National Renewable Energy Laboratory 2008). Currently, the rural areas serve as the primary choice of wind turbine installation because there are less wind obstacles that create wind turbulence, which in turn is disruptive for the proper functioning of the wind turbines, and allows more laminar (streamline) wind flow. However according to various literatures, the installation of wind turbines in rural areas has its drawbacks. The infrastructure is underdeveloped and usually the selected sites require the construction of new roads and transmission lines. The new construction and occasional deforestation lead to soil erosion and environmental degradation. On top of that transporting energy to cities that are the primary consumers of wind energy results in energy transmission loss. Urban areas, on the other hand, have well developed infrastructure, and the installation of turbines on abandoned and contaminated urban lands which are expensive to clean and rehabilitate for other uses would lower installation costs and would have little environmental degradation effect. The objective of this research was to provide a preliminary wind power suitability analysis for installing medium (100 -1000 kW) and large (1000 - 3000 kW) size wind turbines in urban areas, such as city of Chicago. Geographic Information Systems (GIS) and a multi attribute Weighted Linear Combination (WLC) method that is based on the concept of weighted average were primary tools utilized to conduct the analysis. The criteria that were used to select suitable sites were the same criteria used for rural wind farms, such as wind speeds, historic landmarks, avian and wildlife habitat, conservation lands, proximity

  11. Mass spectrometry identifies multiple organophosphorylated sites on tubulin

    International Nuclear Information System (INIS)

    Grigoryan, Hasmik; Schopfer, Lawrence M.; Peeples, Eric S.; Duysen, Ellen G.; Grigoryan, Marine; Thompson, Charles M.; Lockridge, Oksana

    2009-01-01

    Acute toxicity of organophosphorus poisons (OP) is explained by inhibition of acetylcholinesterase in nerve synapses. Low-dose effects are hypothesized to result from modification of other proteins, whose identity is not yet established. The goal of the present work was to obtain information that would make it possible to identify tubulin as a target of OP exposure. Tubulin was selected for study because live mice injected with a nontoxic dose of a biotinylated organophosphorus agent appeared to have OP-labeled tubulin in brain as determined by binding to avidin beads and mass spectrometry. The experiments with live mice were not conclusive because binding to avidin beads could be nonspecific. To be convincing, it is necessary to find and characterize the OP-labeled tubulin peptide. The search for OP-labeled tubulin peptides was begun by identifying residues capable of making a covalent bond with OP. Pure bovine tubulin (0.012 mM) was treated with 0.01-0.5 mM chlorpyrifos oxon for 24 h at 37 o C in pH 8.3 buffer. The identity of labeled amino acids and percent labeling was determined by mass spectrometry. Chlorpyrifos oxon bound covalently to tyrosines 83, 103, 108, 161, 224, 262, 272, 357, and 399 in bovine alpha tubulin, and to tyrosines 50, 51, 59, 106, 159, 281, 310, and 340 in bovine beta tubulin. The most reactive were tyrosine 83 in alpha and tyrosine 281 in beta tubulin. In the presence of 1 mM GTP, percent labeling increased 2-fold. Based on the crystal structure of the tubulin heterodimer (PDB 1jff) tyrosines 83 and 281 are well exposed to solvent. In conclusion seventeen tyrosines in tubulin have the potential to covalently bind chlorpyrifos oxon. These results will be useful when searching for OP-labeled tubulin in live animals.

  12. Target and identify: triazene linker helps identify azidation sites of labelled proteins via click and cleave strategy.

    Science.gov (United States)

    Lohse, Jonas; Schindl, Alexandra; Danda, Natasha; Williams, Chris P; Kramer, Karl; Kuster, Bernhard; Witte, Martin D; Médard, Guillaume

    2017-10-31

    A method for identifying probe modification of proteins via tandem mass spectrometry was developed. Azide bearing molecules are immobilized on functionalised sepharose beads via copper catalysed Huisgen-type click chemistry and selectively released under acidic conditions by chemical cleavage of the triazene linkage. We applied this method to identify the modification site of targeted-diazotransfer on BirA.

  13. Identifying Feasible Locations for Wetland Creation or Restoration in Catchments by Suitability Modelling Using Light Detection and Ranging (LiDAR Digital Elevation Model (DEM

    Directory of Open Access Journals (Sweden)

    Evelyn Uuemaa

    2018-04-01

    Full Text Available Wetlands play a key role in controlling flooding and non-point-source (diffuse pollution. They are therefore an important tool for mitigating diffuse water pollution from farms. However, to use this tool, it is necessary to obtain detailed assessments and identification of potential wetland restoration or creation sites. This is complicated by the diversity of landscapes, environmental conditions, and land ownership. Site suitability for wetland restoration or creation depends on many factors: the underlying geology, soils, topography, hydrology, drainage, and land ownership. Local hydrology and soils are among the most important factors. However, the inventory and characterization of a site’s soils and hydrology often requires extensive, expensive, and time-consuming ground surveys, and it is therefore limited to small areas. Another possibility would be to consider topography, which strongly determines water movement patterns. Light detection and ranging (LiDAR data provides detailed topographic information and can be acquired by remote sensing. Our study showed that terrain analysis using high-resolution topographical data can produce suitability maps for wetlands that can be easily used by decision makers and planners in watershed management. The rapid methodology reveals potential wetland creation or restoration sites at a reasonable cost; with the resulting spatially explicit suitability map, managers can plan for wetland creation or restoration without having to wait for field-data collection.

  14. Multi-locus DNA barcoding identifies matK as a suitable marker for species identification in Hibiscus L.

    Science.gov (United States)

    Poovitha, Sundar; Stalin, Nithaniyal; Balaji, Raju; Parani, Madasamy

    2016-12-01

    The genus Hibiscus L. includes several taxa of medicinal value and species used for the extraction of natural dyes. These applications require the use of authentic plant materials. DNA barcoding is a molecular method for species identification, which helps in reliable authentication by using one or more DNA barcode marker. In this study, we have collected 44 accessions, representing 16 species of Hibiscus, distributed in the southern peninsular India, to evaluate the discriminatory power of the two core barcodes rbcLa and matK together with the suggested additional regions trnH-psbA and ITS2. No intraspecies divergence was observed among the accessions studied. Interspecies divergence was 0%-9.6% with individual markers, which increased to 0%-12.5% and 0.8%-20.3% when using two- and three-marker combinations, respectively. Differentiation of all the species of Hibiscus was possible with the matK DNA barcode marker. Also, in two-marker combinations, only those combinations with matK differentiated all the species. Though all the three-marker combinations showed 100% species differentiation, species resolution was consistently better when the matK marker formed part of the combination. These results clearly showed that matK is more suitable when compared to rbcLa, trnH-psbA, and ITS2 for species identification in Hibiscus.

  15. Central site monitoring: results from a test of accuracy in identifying trials and sites failing Food and Drug Administration inspection.

    Science.gov (United States)

    Lindblad, Anne S; Manukyan, Zorayr; Purohit-Sheth, Tejashri; Gensler, Gary; Okwesili, Paul; Meeker-O'Connell, Ann; Ball, Leslie; Marler, John R

    2014-04-01

    Site monitoring and source document verification account for 15%-30% of clinical trial costs. An alternative is to streamline site monitoring to focus on correcting trial-specific risks identified by central data monitoring. This risk-based approach could preserve or even improve the quality of clinical trial data and human subject protection compared to site monitoring focused primarily on source document verification. To determine whether a central review by statisticians using data submitted to the Food and Drug Administration (FDA) by clinical trial sponsors can identify problem sites and trials that failed FDA site inspections. An independent Analysis Center (AC) analyzed data from four anonymous new drug applications (NDAs) where FDA had performed site inspections overseen by FDA's Office of Scientific Investigations (OSI). FDA team members in the OSI chose the four NDAs from among all NDAs with data in Study Data Tabulation Model (SDTM) format. Two of the NDAs had data that OSI had deemed unreliable in support of the application after FDA site inspections identified serious data integrity problems. The other two NDAs had clinical data that OSI deemed reliable after site inspections. At the outset, the AC knew only that the experimental design specified two NDAs with significant problems. FDA gave the AC no information about which NDAs had problems, how many sites were inspected, or how many were found to have problems until after the AC analysis was complete. The AC evaluated randomization balance, enrollment patterns, study visit scheduling, variability of reported data, and last digit reference. The AC classified sites as 'High Concern', 'Moderate Concern', 'Mild Concern', or 'No Concern'. The AC correctly identified the two NDAs with data deemed unreliable by OSI. In addition, central data analysis correctly identified 5 of 6 (83%) sites for which FDA recommended rejection of data and 13 of 15 sites (87%) for which any regulatory deviations were

  16. Identifying ozone-sensitive communities of (semi-)natural vegetation suitable for mapping exceedance of critical levels

    International Nuclear Information System (INIS)

    Mills, G.; Hayes, F.; Jones, M.L.M.; Cinderby, S.

    2007-01-01

    Using published data on the responses of individual species to ozone, 54 EUNIS (European Nature Information System) level 4 communities with six or more ozone-sensitive species (%OS) and c. 20% or more species tested for ozone sensitivity, were identified as potentially ozone-sensitive. The largest number of these communities (23) was associated with Grasslands, with Heathland, scrub and tundra, and Mires, bogs and fens having the next highest representation at 11 and 8 level 4 communities each respectively. Within the grasslands classification, E4 (Alpine and sub-alpine grasslands), E5 (Woodland fringes and clearings) and E1 (Dry grasslands) were the most sensitive with 68.1, 51.6 and 48.6%OS respectively. It is feasible to map the land-cover for these and other communities at level 2, but it may not be currently possible to map the land-cover for all communities identified to be ozone-sensitive at levels 3 and 4. - Grassland communities such as alpine and sub-alpine grasslands have the highest potential sensitivity ozone, based on the responses of their component species

  17. An assessment of site suitability for marina construction in Istanbul, Turkey, using GIS and AHP multicriteria decision analysis.

    Science.gov (United States)

    Gumusay, Mustafa Umit; Koseoglu, Gokalp; Bakirman, Tolga

    2016-12-01

    Marinas play a key role in sea transportation and tourism. The problem of an insufficient marina capacity has revealed in terms of sea traffic due to the demographic structure and increasing tourism potential of Istanbul which is the biggest metropolitan city of Turkey and has around 600-km-long coastline. Therefore, the study area is mainly focused on the Marmara Sea shoreline of Istanbul. Rather than traditional methods, a rapid and cost-effective solution which considers natural and urban environment conditions is essential to satisfy the need for a marina site selection. Thanks to the latest improvements in geographic information systems, it is convenient to perform location selection analysis of marinas taking advantages of geology, land use, demography and accessibility data sets. The goal of this study is to define the areas that are appropriate for building marinas, with the use of topographic and demographic data in a present shoreline applying analytical hierarchy process multicriteria decision-making method. In this study, erosion, landslide, tsunami, land use, geologically hazardous areas, transfer lines, sea traffic data, neighbourhood scale population, age patterns and house income data have been used. Analytical hierarchy process method is used to give a weight to each data set, and a grading system has been developed for the area selection of marinas. The result maps of the analysis that show study area as classified into four categories from good to not suitable are presented. It is possible to create a decision support system for upper scale plans that enable authorities to perform analysis accurately, cost and time effectively using the proposed methodology that integrates multiple data sets with different scales and types.

  18. Identifying patients suitable for palliative care - a descriptive analysis of enquiries using a Case Management Process Model approach

    Directory of Open Access Journals (Sweden)

    Kuhn Ulrike

    2012-11-01

    Full Text Available Abstract Background In Germany, case management in a palliative care unit was first implemented in 2005 at the Department of Palliative Medicine at the University Hospital Cologne. One of the purposes of this case management is to deal with enquiries from patients and their relatives as well as medical professionals. Using the Case Management Process Model of the Case Management Society of America as a reference, this study analysed (a how this case management was used by different enquiring groups and (b how patients were identified for case management and for palliative care services. The first thousand enquiries were analysed considering patient variables, properties of the enquiring persons and the content of the consultations. Results Most enquiries to the case management were made by telephone. The majority of requests regarded patients with oncological disease (84.3 %. The largest enquiring group was composed of patients and relatives (40.8 %, followed by internal professionals of the hospital (36.1 %. Most of the enquiring persons asked for a patient’s admission to the palliative care ward (46.4 %. The second most frequent request was for consultation and advice (30.9 %, followed by requests for the palliative home care service (13.3 %. Frequent reasons for actual admissions were the need for the treatment of pain, the presence of symptoms and the need for nursing care. More than half of the enquiries concerning admission to the palliative care ward were followed by an admission. Conclusions Case management has been made public among the relevant target groups. Case management as described by the Case Management Process Model helps to identify patients likely to benefit from case management and palliative care services. In addition, with the help of case management palliative patients may be allocated to particular health care services.

  19. Lipid ratio as a suitable tool to identify individuals with MetS risk: A case- control study.

    Science.gov (United States)

    Abbasian, Maryam; Delvarianzadeh, Mehri; Ebrahimi, Hossein; Khosravi, Farideh

    2017-11-01

    This study aimed to compare the serum lipids ratio in staff with and without metabolic syndrome (MetS) who were working in Shahroud University of Medical Sciences. This case-control study was conducted in 2015 on 499 personnel aged 30-60 years old. ATP III criteria were used to diagnose patients with MetS. The data were analyzed by using logistic regression and ROC curve. Mean lipid ratio was higher in individuals having the MetS in both sexes compared with those without. In addition, the mean levels of lipid ratios significantly increased with increasing number of MetS components in both sexes. Also it could be concluded that TG/HDL-C ratio is the best marker for the diagnosis of MetS in men and women. Moreover, the cut-off point for the TG/HDL-C was 2.86 in women and 4.03 in men. It was found that for any unit of increases in the TG/HDL-C, the risk of developing the MetS will increase by 2.12 times. TG/HDL-C ratio is found to be the best clinical marker for the diagnosis of MetS compare with other lipid ratios, therefore it is recommended to be used as a feasible tool to identify individuals with MetS risk. Copyright © 2016 Diabetes India. Published by Elsevier Ltd. All rights reserved.

  20. Site suitability analysis for Bay scallop aquaculture and implications for sustainable fisheries management in the Ha Long Bay archipelago, northern Vietnam

    Directory of Open Access Journals (Sweden)

    Pham Thi Khanh

    2013-01-01

    Full Text Available Mollusc culture if properly managed, may help decrease capture fisheries over-exploitation in Vietnam, and possibly become an alternative income for local fishermen. The definition and characterization of zones suitable for aquaculture is pivotal for its success and sustainable development, and this study aims at determining the suitability of Argopecten irradians (Bay scallop culture in the Ha Long Bay Archipelago. Temperature, salinity, chlorophyll-a, total suspended solid and bathymetry, were compiled in an environmental suitability model. Distance of culture sites from landing points and fish markets were instead grouped in an infrastructural suitability model. In both models, developed with Geographic Information Systems, the suitability scores were ranked on a scale from 1 (unsuitable to 6 (very-highly suitable. Results showed that 98 % of the studied area is environmentally suitable for such culture. However, overlaying the infrastructural factors the suitable zone decrease to 38 %. Advantages and disadvantages of two management options were then discussed: (a strengthening fisheries infrastructures or (b developing post harvesting processing plants.

  1. Assessment of land suitability for olive mill wastewater disposal site selection by integrating fuzzy logic, AHP, and WLC in a GIS.

    Science.gov (United States)

    Aydi, Abdelwaheb; Abichou, Tarek; Nasr, Imen Hamdi; Louati, Mourad; Zairi, Moncef

    2016-01-01

    This paper presents a geographic information system-based multi-criteria site selection tool of an olive mill wastewater (OMW) disposal site in Sidi Bouzid Region, Tunisia. The multi-criteria decision framework integrates ten constraints and six factors that relate to environmental and economic concerns, and builds a hierarchy model for OMW disposal site suitability. The methodology is used for preliminary assessment of the most suitable OMW disposal sites by combining fuzzy set theory and analytic hierarchy process (AHP). The fuzzy set theory is used to standardize factors using different fuzzy membership functions while the AHP is used to establish the relative importance of the criteria. The AHP makes pairwise comparisons of relative importance between hierarchy elements grouped by both environmental and economic decision criteria. The OMW disposal site suitability is achieved by applying a weighted linear combination that uses a comparison matrix to aggregate different importance scenarios associated with environmental and economic objectives. Three different scenarios generated by different weights applied to the two objectives. The scenario (a) assigns a weight of 0.75 to the environmental and 0.25 to the economic objective, scenario (b) has equal weights, and scenario (c) features weights of 0.25 and 0.75 for environmental and economic objectives, respectively. The results from this study assign the least suitable OMW disposal site of 2.5 % when environmental and economic objectives are rated equally, while a more suitable OMW disposal site of 1.0 % is generated when the economic objective is rated higher.

  2. Site suitability report in the matter of Clinch River Breeder Reactor Plant. Docket No. 50-537. Revision to March 4, 1977 report

    International Nuclear Information System (INIS)

    1982-06-01

    In March 1977, the Office of Nuclear Reactor Regulation issued its Site Suitability Report (SSR) for the proposed Clinch River Breeder Plant (CRBRP). That SSR documents the result of the staff's evaluation of the suitability of the proposed CRBRP site for a facility of the general size and type as the CRBRP from the standpoint of radiological health and safety considerations. The staff concluded in that SSR that the proposed CRBRP site is suitable for such a facility. Since the SSR was issued, several modifications have been made to the CRBRP design, additional data related to the site and its environs have been collected, and the Fast Flux Test Facility, a technological precursor to the CRBRP, has been completed and has commenced operation. In addition, new emergency planning requirements have been promulgated by the staff. This report is an update of the March 1977 SSR that reflects these matters and discusses them in terms of the previous staff conclusion regarding the suitability of the proposed CRBRP site

  3. A spatial modeling approach to identify potential butternut restoration sites in Mammoth Cave National Park

    Science.gov (United States)

    Thompson, L.M.; Van Manen, F.T.; Schlarbaum, S.E.; DePoy, M.

    2006-01-01

    Incorporation of disease resistance is nearly complete for several important North American hardwood species threatened by exotic fungal diseases. The next important step toward species restoration would be to develop reliable tools to delineate ideal restoration sites on a landscape scale. We integrated spatial modeling and remote sensing techniques to delineate potential restoration sites for Butternut (Juglans cinerea L.) trees, a hardwood species being decimated by an exotic fungus, in Mammoth Cave National Park (MCNP), Kentucky. We first developed a multivariate habitat model to determine optimum Butternut habitats within MCNP. Habitat characteristics of 54 known Butternut locations were used in combination with eight topographic and land use data layers to calculate an index of habitat suitability based on Mahalanobis distance (D2). We used a bootstrapping technique to test the reliability of model predictions. Based on a threshold value for the D2 statistic, 75.9% of the Butternut locations were correctly classified, indicating that the habitat model performed well. Because Butternut seedlings require extensive amounts of sunlight to become established, we used canopy cover data to refine our delineation of favorable areas for Butternut restoration. Areas with the most favorable conditions to establish Butternut seedlings were limited to 291.6 ha. Our study provides a useful reference on the amount and location of favorable Butternut habitat in MCNP and can be used to identify priority areas for future Butternut restoration. Given the availability of relevant habitat layers and accurate location records, our approach can be applied to other tree species and areas. ?? 2006 Society for Ecological Restoration International.

  4. Benchmark data for identifying N6-methyladenosine sites in the Saccharomyces cerevisiae genome

    Directory of Open Access Journals (Sweden)

    Wei Chen

    2015-12-01

    Full Text Available This data article contains the benchmark dataset for training and testing iRNA-Methyl, a web-server predictor for identifying N6-methyladenosine sites in RNA (Chen et al., 2015 [15]. It can also be used to develop other predictors for identifying N6-methyladenosine sites in the Saccharomyces cerevisiae genome.

  5. Evidentiary requirements to identify potentially acceptable sites (PAS) in crystalline rock

    International Nuclear Information System (INIS)

    Comella, P.A.; Smith, B.H.

    1985-01-01

    This report contains information on the evidentiary requirements to identify potentially acceptable sites in crystalline rock for waste disposal. Topics addressed include: chronology, key regulatory assumptions, statutory framework for identifying potentially acceptable sites, application of 10 disqualifiers, consideration of favorable and potentially adverse conditions, a composite favorability analysis, and a proposed outline for PAS identification decision document

  6. Land suitability assessment for wind power plant site selection using ANP-DEMATEL in a GIS environment: case study of Ardabil province, Iran.

    Science.gov (United States)

    Azizi, Ali; Malekmohammadi, Bahram; Jafari, Hamid Reza; Nasiri, Hossein; Amini Parsa, Vahid

    2014-10-01

    Wind energy is a renewable energy resource that has increased in usage in most countries. Site selection for the establishment of large wind turbines, called wind farms, like any other engineering project, requires basic information and careful planning. This study assessed the possibility of establishing wind farms in Ardabil province in northwestern Iran by using a combination of analytic network process (ANP) and decision making trial and evaluation laboratory (DEMATEL) methods in a geographical information system (GIS) environment. DEMATEL was used to determine the criteria relationships. The weights of the criteria were determined using ANP and the overlaying process was done on GIS. Using 13 information layers in three main criteria including environmental, technical and economical, the land suitability map was produced and reclassified into 5 equally scored divisions from least suitable to most suitable areas. The results showed that about 6.68% of the area of Ardabil province is most suitable for establishment of wind turbines. Sensitivity analysis shows that significant portions of these most suitable zones coincide with suitable divisions of the input layers. The efficiency and accuracy of the hybrid model (ANP-DEMATEL) was evaluated and the results were compared to the ANP model. The sensitivity analysis, map classification, and factor weights for the two methods showed satisfactory results for the ANP-DEMATEL model in wind power plant site selection.

  7. Regulatory O-GlcNAcylation sites on FoxO1 are yet to be identified

    Energy Technology Data Exchange (ETDEWEB)

    Fardini, Yann [INSERM, U1016, Institut Cochin, Paris (France); CNRS, UMR8104, Paris (France); Université Paris Descartes, Sorbonne Paris Cité, Paris (France); Perez-Cervera, Yobana [Structural and Functional Glycobiology Unit, Lille 1 University, CNRS (UMR 8576), IFR 117, Villeneuve d' Ascq (France); Facultad de Odontología, Universidad Autónoma Benito Juárez de Oaxaca, Oaxaca (Mexico); Camoin, Luc [INSERM, U1068, CRCM, Marseille Protéomique IBiSA, Marseille, F-13009 (France); Institut Paoli-Calmettes Team, Cell Polarity, Cell Signaling and Cancer, Marseille, F-13009 (France); Aix-Marseille Université, F-13284, Marseille (France); CNRS, UMR7258, CRCM, Marseille, F-13009 (France); Pagesy, Patrick [INSERM, U1016, Institut Cochin, Paris (France); CNRS, UMR8104, Paris (France); Université Paris Descartes, Sorbonne Paris Cité, Paris (France); Lefebvre, Tony [Structural and Functional Glycobiology Unit, Lille 1 University, CNRS (UMR 8576), IFR 117, Villeneuve d' Ascq (France); Issad, Tarik, E-mail: tarik.issad@inserm.fr [INSERM, U1016, Institut Cochin, Paris (France); CNRS, UMR8104, Paris (France); Université Paris Descartes, Sorbonne Paris Cité, Paris (France)

    2015-06-26

    O-GlcNAcylation is a reversible post-translational modification that regulates cytosolic and nuclear proteins. We and others previously demonstrated that FoxO1 is O-GlcNAcylated in different cell types, resulting in an increase in its transcriptional activity. Four O-GlcNAcylation sites were identified in human FOXO1 but directed mutagenesis of each site individually had modest (T317) or no effect (S550, T648, S654) on its O-GlcNAcylation status and transcriptional activity. Moreover, the consequences of mutating all four sites had not been investigated. In the present work, we mutated these sites in the mouse Foxo1 and found that mutation of all four sites did not decrease Foxo1 O-GlcNAcylation status and transcriptional activity, and would even tend to increase them. In an attempt to identify other O-GlcNAcylation sites, we immunoprecipitated wild-type O-GlcNAcylated Foxo1 and analysed the tryptic digest peptides by mass spectrometry using High-energy Collisional Dissociation. We identified T646 as a new O-GlcNAcylation site on Foxo1. However, site directed mutagenesis of this site individually or together with all four previously identified residues did not impair Foxo1 O-GlcNAcylation and transcriptional activity. These results suggest that residues important for the control of Foxo1 activity by O-GlcNAcylation still remain to be identified. - Highlights: • We mutate four previously identified O-GlcNAcylation sites on Foxo1. • Unexpectedly, these mutations do not reduce Foxo1 O-GlcNAcylation. • These mutation do not reduce Foxo1 transcriptional activity. • We identify a new O-GlcNAcylation site on Foxo1 by mass spectrometry. • Mutation of this site increases Foxo1 transcriptional activity.

  8. Regulatory O-GlcNAcylation sites on FoxO1 are yet to be identified

    International Nuclear Information System (INIS)

    Fardini, Yann; Perez-Cervera, Yobana; Camoin, Luc; Pagesy, Patrick; Lefebvre, Tony; Issad, Tarik

    2015-01-01

    O-GlcNAcylation is a reversible post-translational modification that regulates cytosolic and nuclear proteins. We and others previously demonstrated that FoxO1 is O-GlcNAcylated in different cell types, resulting in an increase in its transcriptional activity. Four O-GlcNAcylation sites were identified in human FOXO1 but directed mutagenesis of each site individually had modest (T317) or no effect (S550, T648, S654) on its O-GlcNAcylation status and transcriptional activity. Moreover, the consequences of mutating all four sites had not been investigated. In the present work, we mutated these sites in the mouse Foxo1 and found that mutation of all four sites did not decrease Foxo1 O-GlcNAcylation status and transcriptional activity, and would even tend to increase them. In an attempt to identify other O-GlcNAcylation sites, we immunoprecipitated wild-type O-GlcNAcylated Foxo1 and analysed the tryptic digest peptides by mass spectrometry using High-energy Collisional Dissociation. We identified T646 as a new O-GlcNAcylation site on Foxo1. However, site directed mutagenesis of this site individually or together with all four previously identified residues did not impair Foxo1 O-GlcNAcylation and transcriptional activity. These results suggest that residues important for the control of Foxo1 activity by O-GlcNAcylation still remain to be identified. - Highlights: • We mutate four previously identified O-GlcNAcylation sites on Foxo1. • Unexpectedly, these mutations do not reduce Foxo1 O-GlcNAcylation. • These mutation do not reduce Foxo1 transcriptional activity. • We identify a new O-GlcNAcylation site on Foxo1 by mass spectrometry. • Mutation of this site increases Foxo1 transcriptional activity

  9. Third report, development of site suitability and design performance data base for a high level nuclear waste repository

    International Nuclear Information System (INIS)

    1978-05-01

    This report presents the results of mining and geotechnical studies provided as support for the development of a technical data base suitable for the generation of a regulatory framework governing high-level nuclear waste disposal: flow path models for basalts, salt domes, and crystalline rocks; simplistic model evaluations; loss of administrative control; repository conceptual designs; repository design considerations; and design performance criteria

  10. Under What Assumptions Do Site-by-Treatment Instruments Identify Average Causal Effects?

    Science.gov (United States)

    Reardon, Sean F.; Raudenbush, Stephen W.

    2013-01-01

    The increasing availability of data from multi-site randomized trials provides a potential opportunity to use instrumental variables methods to study the effects of multiple hypothesized mediators of the effect of a treatment. We derive nine assumptions needed to identify the effects of multiple mediators when using site-by-treatment interactions…

  11. Deep mutational scanning identifies sites in influenza nucleoprotein that affect viral inhibition by MxA.

    Directory of Open Access Journals (Sweden)

    Orr Ashenberg

    2017-03-01

    Full Text Available The innate-immune restriction factor MxA inhibits influenza replication by targeting the viral nucleoprotein (NP. Human influenza virus is more resistant than avian influenza virus to inhibition by human MxA, and prior work has compared human and avian viral strains to identify amino-acid differences in NP that affect sensitivity to MxA. However, this strategy is limited to identifying sites in NP where mutations that affect MxA sensitivity have fixed during the small number of documented zoonotic transmissions of influenza to humans. Here we use an unbiased deep mutational scanning approach to quantify how all single amino-acid mutations to NP affect MxA sensitivity in the context of replication-competent virus. We both identify new sites in NP where mutations affect MxA resistance and re-identify mutations known to have increased MxA resistance during historical adaptations of influenza to humans. Most of the sites where mutations have the greatest effect are almost completely conserved across all influenza A viruses, and the amino acids at these sites confer relatively high resistance to MxA. These sites cluster in regions of NP that appear to be important for its recognition by MxA. Overall, our work systematically identifies the sites in influenza nucleoprotein where mutations affect sensitivity to MxA. We also demonstrate a powerful new strategy for identifying regions of viral proteins that affect inhibition by host factors.

  12. 10 CFR Appendix IV to Part 960 - Types of Information for the Nomination of Sites as Suitable for Characterization

    Science.gov (United States)

    2010-01-01

    ... contained in other areas of similar size in the geologic setting. • Past and present drilling and mining.... The types of information to support this description should include— • Topography of the site...

  13. What requirements does the KBS-3 repository make on the host rock? Geoscientific suitability indicators and criteria for siting and site evaluation

    International Nuclear Information System (INIS)

    Andersson, Johan; Stroem, Anders; Svemar, Christer; Almen, Karl-Erik; Ericsson, Lars O.

    2000-04-01

    This report gives an account of what requirements are made on the rock, what conditions in the rock are advantageous and how the fulfilment of requirements and preferences is to be judged prior to the selection of sites for a site investigation and during a site investigation. The conclusions and results of the report are based on the knowledge and experience acquired by SKB over many years of research and development. The results, and particularly the stipulated criteria, apply to a repository for spent fuel of the KBS-3 type, i.e. a repository where the fuel is contained in copper canisters embedded in bentonite clay at a depth of 400 - 700 m in the Swedish crystalline basement. The report analyzes how the rock's different geological conditions, mechanical, thermal, hydrogeological, chemical and transport properties influence the functions of the deep repository, and whether it is possible to determine requirements and preferences regarding the influence of these properties. Where possible, these requirements or preferences have then been translated into requirements or preferences regarding the individual properties. Criteria are formulated that are based on the quantities that can be measured or estimated at the relevant stage of the investigation. The following requirements are made on the rock: The rock in the repository's deposition zone may not have any ore potential. Regional plastic shear zones shall be avoided if it cannot be demonstrated that the properties of the zone do not deviate from those of the rest of the rock. There may, however, be so-called 'tectonic lenses' near regional plastic shear zones where the bedrock is homogeneous and relatively unaffected. Deposition tunnels and deposition holes for canisters may not pass through or be positioned too close to major regional and major local fracture zones. Deposition holes may not intersect identified local minor fracture zones. The rock's strength, fracture geometry and initial stresses may not be

  14. Use of CFD modeling for estimating spatial representativeness of urban air pollution monitoring sites and suitability of their locations

    International Nuclear Information System (INIS)

    Santiago, J. L.; Martin, F.

    2015-01-01

    A methodology to estimate the spatial representativeness of air pollution monitoring sites is applied to two urban districts. This methodology is based on high resolution maps of air pollution computed by using Computational Fluid Dynamics (CFD) modelling tools. Traffic-emitted NO 2 dispersion is simulated for several meteorological conditions taking into account the effect of the buildings on air flow and pollutant dispersion and using a steady state CFD-RANS approach. From these results, maps of average pollutant concentrations for January -May 2011 are computed as a combination of the simulated scenarios. Two urban districts of Madrid City were simulated. Spatial representativeness areas for 32 different sites within the same district (including the site of the operative air quality stations) have been estimated by computing the portion of the domains with average NO 2 concentration differing less than a 20% of the concentration at each candidate monitoring site. New parameters such as the ratio AR between the representativeness area and the whole domain area or the representativeness index (IR) has been proposed to discuss and compare the representativeness areas. Significant differences between the spatial representativeness of the candidate sites of both studied districts have been found. The sites of the Escuelas Aguirre district have generally smaller representativeness areas than those of the Plaza de Castilla. More stations are needed to cover the Escuelas Aguirre district than for the Plaza de Castilla one. The operative air quality station of the Escuelas Aguirre district is less representative than the station of the Plaza de Castilla district. The cause of these differences seems to be the differences in urban structure of both districts prompting different ventilation. (Author)

  15. Use of CFD modeling for estimating spatial representativeness of urban air pollution monitoring sites and suitability of their locations

    Energy Technology Data Exchange (ETDEWEB)

    Santiago, J. L.; Martin, F.

    2015-07-01

    A methodology to estimate the spatial representativeness of air pollution monitoring sites is applied to two urban districts. This methodology is based on high resolution maps of air pollution computed by using Computational Fluid Dynamics (CFD) modelling tools. Traffic-emitted NO{sub 2} dispersion is simulated for several meteorological conditions taking into account the effect of the buildings on air flow and pollutant dispersion and using a steady state CFD-RANS approach. From these results, maps of average pollutant concentrations for January -May 2011 are computed as a combination of the simulated scenarios. Two urban districts of Madrid City were simulated. Spatial representativeness areas for 32 different sites within the same district (including the site of the operative air quality stations) have been estimated by computing the portion of the domains with average NO{sub 2} concentration differing less than a 20% of the concentration at each candidate monitoring site. New parameters such as the ratio AR between the representativeness area and the whole domain area or the representativeness index (IR) has been proposed to discuss and compare the representativeness areas. Significant differences between the spatial representativeness of the candidate sites of both studied districts have been found. The sites of the Escuelas Aguirre district have generally smaller representativeness areas than those of the Plaza de Castilla. More stations are needed to cover the Escuelas Aguirre district than for the Plaza de Castilla one. The operative air quality station of the Escuelas Aguirre district is less representative than the station of the Plaza de Castilla district. The cause of these differences seems to be the differences in urban structure of both districts prompting different ventilation. (Author)

  16. Use of CFD modeling for estimating spatial representativeness of urban air pollution monitoring sites and suitability of their locations

    Energy Technology Data Exchange (ETDEWEB)

    Santiago, J.L.; Martin, F.

    2015-07-01

    A methodology to estimate the spatial representativeness of air pollution monitoring sites is applied to two urban districts. This methodology is based on high resolution maps of air pollution computed by using Computational Fluid Dynamics (CFD) modelling tools. Traffic-emitted NO2 dispersion is simulated for several meteorological conditions taking into account the effect of the buildings on air flow and pollutant dispersion and using a steady state CFD-RANS approach. From these results, maps of average pollutant concentrations for January–May 2011 are computed as a combination of the simulated scenarios. Two urban districts of Madrid City were simulated. Spatial representativeness areas for 32 different sites within the same district (including the site of the operative air quality stations) have been estimated by computing the portion of the domains with average NO2 concentration differing less than a 20% of the concentration at each candidate monitoring site. New parameters such as the ratio AR between the representativeness area and the whole domain area or the representativeness index (IR) has been proposed to discuss and compare the representativeness areas. Significant differences between the spatial representativeness of the candidate sites of both studied districts have been found. The sites of the Escuelas Aguirre district have generally smaller representativeness areas than those of the Plaza de Castilla. More stations are needed to cover the Escuelas Aguirre district than for the Plaza de Castilla one. The operative air quality station of the Escuelas Aguirre district is less representative than the station of the Plaza de Castilla district. The cause of these differences seems to be the differences in urban structure of both districts prompting different ventilation. (Author)

  17. Suitability of containers from different sources as breeding sites of Aedes aegypti (L. in a cemetery of Buenos Aires City, Argentina

    Directory of Open Access Journals (Sweden)

    Darío Vezzani

    2002-09-01

    Full Text Available Cemeteries are ideal urban areas to study the importance of different types of containers as breeding sites of Aedes aegypti (L.. In the present study, the suitability of plastic, glass, ceramic and metal containers was evaluated in four patches within a cemetery of Buenos Aires City, Argentina. Between October 1998 and May 2000, we found 215 breeding sites of Ae. aegypti out of 13,022 water-filled containers examined. In two patches containing microenvironments sheltered from the sun, the use of the different types of containers was proportional to the offer (correlation coefficient = 0.99, P < 0.05 in both cases. In the remaining patches, plastic and metal containers were the most and less frequent breeding sites, respectively (P < 0.001 in both cases. The number of immatures per breeding site (median = 4.5 did not show significant differences among the four types of containers examined (H3, 215 = 1.216, P = 0.749. Differences found in patches from a same cemetery suggest that different microenvironmental conditions affect the suitability of each type of container for Ae. aegypti breeding. Plastic containers appeared as key breeding sites that should be removed to reduce the Ae. aegypti population in the study area.

  18. Perryman Nuclear Power Plant. Site suitability--site safety report, volume I: chapters-sections 1.1, 1.2, 1.4, 1.6; 2.1, 2.2

    International Nuclear Information System (INIS)

    1977-01-01

    A site suitability report is submitted in support of the Baltimore Gas and Electric Company application for a limited early site review of a potential nuclear power plant. The Perryman Nuclear Power Plant site is located in northeastern Maryland on an arm of the Chesapeake Bay estuary approximately 17 miles east--northeast of Baltimore. The proposed plant is a two-unit light water reactor with a 3800 MW(t) power level for each unit. General descriptions of the site geography, demography, nearby facilities, and meteorology are presented

  19. Plant species potentially suitable for cover on low-level solid nuclear waste disposal sites: a literature review

    International Nuclear Information System (INIS)

    Brenkert, A.L.; Parr, P.D.; Taylor, F.G.

    1984-09-01

    This report reviews available literature on soil conditions, hydrology, and climatological data and suggests plant species suitable for covering the low-level nuclear waste disposal areas in the White Oak Creek Watershed within the Oak Ridge Reservation. Literature on naturally invading species and secondary succession, on plant species used for reclamation of coal spoils and roadsides, and on horticultural species is reviewed. The potential of plant species to take up, or mine, the waste through deep rooting is assessed. The effects of vegetation cover on the water balance in a watershed are reviewed. Several conclusions are presented concerning the management of vegetation cover on low-level solid waste disposal areas. 163 references, 2 figures, 9 tables

  20. Plant species potentially suitable for cover on low-level solid nuclear waste disposal sites: a literature review

    Energy Technology Data Exchange (ETDEWEB)

    Brenkert, A.L.; Parr, P.D.; Taylor, F.G.

    1984-09-01

    This report reviews available literature on soil conditions, hydrology, and climatological data and suggests plant species suitable for covering the low-level nuclear waste disposal areas in the White Oak Creek Watershed within the Oak Ridge Reservation. Literature on naturally invading species and secondary succession, on plant species used for reclamation of coal spoils and roadsides, and on horticultural species is reviewed. The potential of plant species to take up, or mine, the waste through deep rooting is assessed. The effects of vegetation cover on the water balance in a watershed are reviewed. Several conclusions are presented concerning the management of vegetation cover on low-level solid waste disposal areas. 163 references, 2 figures, 9 tables.

  1. Development of computational fluid dynamics--habitat suitability (CFD-HSI) models to identify potential passage--Challenge zones for migratory fishes in the Penobscot River

    Science.gov (United States)

    Haro, Alexander J.; Dudley, Robert W.; Chelminski, Michael

    2012-01-01

    A two-dimensional computational fluid dynamics-habitat suitability (CFD–HSI) model was developed to identify potential zones of shallow depth and high water velocity that may present passage challenges for five anadromous fish species in the Penobscot River, Maine, upstream from two existing dams and as a result of the proposed future removal of the dams. Potential depth-challenge zones were predicted for larger species at the lowest flow modeled in the dam-removal scenario. Increasing flows under both scenarios increased the number and size of potential velocity-challenge zones, especially for smaller species. This application of the two-dimensional CFD–HSI model demonstrated its capabilities to estimate the potential effects of flow and hydraulic alteration on the passage of migratory fish.

  2. A comparison of the suitability of different willow varieties to treat on-site wastewater effluent in an Irish climate.

    Science.gov (United States)

    Curneen, S J; Gill, L W

    2014-01-15

    Short rotation coppiced willow trees can be used to treat on-site wastewater effluent with the advantage that, if planted in a sealed basin and sized correctly, they produce no effluent discharge. This paper has investigated the evapotranspiration rate of four different willow varieties while also monitoring the effects of three different effluent types on each variety. The willow varieties used are all cultivars of Salix viminalis. The effluents applied were primary (septic tank) effluent, secondary treated effluent and rain water (control). The results obtained showed that the addition of effluent had a positive effect on the evapotranspiration. The willows were also found to uptake a high proportion of the nitrogen and phosphorus from the primary and secondary treated effluents added during the first year. The effect of the different effluents on the evapotranspiration rate has been used to design ten full scale on-site treatment systems which are now being monitored. Copyright © 2013 Elsevier Ltd. All rights reserved.

  3. Final site environmental statement: Blue Hills Station, Unit Nos. 1 and 2. Related to the determination of the suitability of Site G for eventual construction. Docket Nos. 50-510 and 50-511

    International Nuclear Information System (INIS)

    1978-07-01

    The site suitability analysis is based on the assumption that the Blue Hills Station will employ two pressurized water reactors to produce outputs of approximately 2814 MWt each. Two steam turbine generators will use the heat produced to provide approximately 957 MWe (gross) each. The exhaust steam will be cooled by four low-profile round mechanical-draft cooling towers. Assuming construction of a nuclear station at site G, a summary of environmental impacts and adverse effects is presented

  4. What requirements does the KBS-3 repository make on the host rock? Geoscientific suitability indicators and criteria for siting and site evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Andersson, Johan [Golder Grundteknik AB (Sweden); Stroem, Anders; Svemar, Christer [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden); Almen, Karl-Erik [KEA Geo-Konsult AB, Naessjoe (Sweden); Ericsson, Lars O. [Chalmers University of Technology, Goeteborg (Sweden)

    2000-04-01

    This report gives an account of what requirements are made on the rock, what conditions in the rock are advantageous and how the fulfilment of requirements and preferences is to be judged prior to the selection of sites for a site investigation and during a site investigation. The conclusions and results of the report are based on the knowledge and experience acquired by SKB over many years of research and development. The results, and particularly the stipulated criteria, apply to a repository for spent fuel of the KBS-3 type, i.e. a repository where the fuel is contained in copper canisters embedded in bentonite clay at a depth of 400 - 700 m in the Swedish crystalline basement. The report analyzes how the rock's different geological conditions, mechanical, thermal, hydrogeological, chemical and transport properties influence the functions of the deep repository, and whether it is possible to determine requirements and preferences regarding the influence of these properties. Where possible, these requirements or preferences have then been translated into requirements or preferences regarding the individual properties. Criteria are formulated that are based on the quantities that can be measured or estimated at the relevant stage of the investigation. The following requirements are made on the rock: The rock in the repository's deposition zone may not have any ore potential. Regional plastic shear zones shall be avoided if it cannot be demonstrated that the properties of the zone do not deviate from those of the rest of the rock. There may, however, be so-called 'tectonic lenses' near regional plastic shear zones where the bedrock is homogeneous and relatively unaffected. Deposition tunnels and deposition holes for canisters may not pass through or be positioned too close to major regional and major local fracture zones. Deposition holes may not intersect identified local minor fracture zones. The rock's strength, fracture geometry and

  5. GASS-WEB: a web server for identifying enzyme active sites based on genetic algorithms.

    Science.gov (United States)

    Moraes, João P A; Pappa, Gisele L; Pires, Douglas E V; Izidoro, Sandro C

    2017-07-03

    Enzyme active sites are important and conserved functional regions of proteins whose identification can be an invaluable step toward protein function prediction. Most of the existing methods for this task are based on active site similarity and present limitations including performing only exact matches on template residues, template size restraints, despite not being capable of finding inter-domain active sites. To fill this gap, we proposed GASS-WEB, a user-friendly web server that uses GASS (Genetic Active Site Search), a method based on an evolutionary algorithm to search for similar active sites in proteins. GASS-WEB can be used under two different scenarios: (i) given a protein of interest, to match a set of specific active site templates; or (ii) given an active site template, looking for it in a database of protein structures. The method has shown to be very effective on a range of experiments and was able to correctly identify >90% of the catalogued active sites from the Catalytic Site Atlas. It also managed to achieve a Matthew correlation coefficient of 0.63 using the Critical Assessment of protein Structure Prediction (CASP 10) dataset. In our analysis, GASS was ranking fourth among 18 methods. GASS-WEB is freely available at http://gass.unifei.edu.br/. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

  6. Toward identifying the next generation of superfund and hazardous waste site contaminants.

    Science.gov (United States)

    Ela, Wendell P; Sedlak, David L; Barlaz, Morton A; Henry, Heather F; Muir, Derek C G; Swackhamer, Deborah L; Weber, Eric J; Arnold, Robert G; Ferguson, P Lee; Field, Jennifer A; Furlong, Edward T; Giesy, John P; Halden, Rolf U; Henry, Tala; Hites, Ronald A; Hornbuckle, Keri C; Howard, Philip H; Luthy, Richard G; Meyer, Anita K; Sáez, A Eduardo; Vom Saal, Frederick S; Vulpe, Chris D; Wiesner, Mark R

    2011-01-01

    This commentary evolved from a workshop sponsored by the National Institute of Environmental Health Sciences titled "Superfund Contaminants: The Next Generation" held in Tucson, Arizona, in August 2009. All the authors were workshop participants. Our aim was to initiate a dynamic, adaptable process for identifying contaminants of emerging concern (CECs) that are likely to be found in future hazardous waste sites, and to identify the gaps in primary research that cause uncertainty in determining future hazardous waste site contaminants. Superfund-relevant CECs can be characterized by specific attributes: They are persistent, bioaccumulative, toxic, occur in large quantities, and have localized accumulation with a likelihood of exposure. Although still under development and incompletely applied, methods to quantify these attributes can assist in winnowing down the list of candidates from the universe of potential CECs. Unfortunately, significant research gaps exist in detection and quantification, environmental fate and transport, health and risk assessment, and site exploration and remediation for CECs. Addressing these gaps is prerequisite to a preventive approach to generating and managing hazardous waste sites. A need exists for a carefully considered and orchestrated expansion of programmatic and research efforts to identify, evaluate, and manage CECs of hazardous waste site relevance, including developing an evolving list of priority CECs, intensifying the identification and monitoring of likely sites of present or future accumulation of CECs, and implementing efforts that focus on a holistic approach to prevention.

  7. Identifying areas suitable for wine tourism through the use of multi-criteria and geographic information system: the method and its application in the countryside around Mount Etna (Sicily

    Directory of Open Access Journals (Sweden)

    Lara Riguccio

    2017-06-01

    Full Text Available Vineyards are among the crops that shape quality landscapes. Many places in the world are famous for their unique wine landscapes which play an important role in the development of tourism in the rural areas. Among these, the wine landscape surrounding mount Etna (Sicily emerges due to its undisputed value, as it is an important component of the territory recognised as a World Heritage Site by UNESCO. This work was conducted with that in mind, in order to identify the most suitable areas for wine tourism on the slopes of our volcano. The method used assigns a great importance to the quality of the landscape, an indispensable resource for encouraging wine tourism, and considers it to be of equal importance with the production of the wines themselves. The present work uses multi-criteria analysis in combination with geographic information system (GIS. Numerous indicators describing local resources were weighed and spatialized. The GIS analysis allowed for the development of various intermediate maps, which allowed to draw up the final suitability map for wine tourism, identifying areas larger than those of the actual vineyards. The value of these areas and the quality of their landscapes are closely connected to the production of the wines in the zone. It could be the target for specific plans and projects aimed at using the available resources, to develop wine tourism in rural areas. Although the study only covers a limited geographical area, the methodology used has general validity and could be used in other contexts.

  8. Selection Criteria of Sites Suitable for Low- Level Radioactive U-mining and Milling wastes Disposal at Al-Missikat-Al-Aradiya District, Eastern Desert, Egypt

    International Nuclear Information System (INIS)

    Abdel-Monem, A.A.; Rabei, S.I.; El-Kiki, M.F.; Guirguis, G.P.; Rabei, S.I.

    1999-01-01

    Uranium mining and milling tailings are U-depleted but contain 230 TH and 226 Ra. These low-level radioactive wastes are disposed of in the near surface environment. Hydro geologically, suitable sites for disposal of these wastes should be characterized by:1) deep water-level,2) minimal precipitation,3) minimal exposure to flooding and 4) circular- shaped basins. Al-Missikat-Al-Aradiya District with future potential of U-mining and milling operations, a geomorphologic analysis led to the selection of four sites (sub basins) having the geomorphologic characteristics:1)elongation and circularity ratio≡1, 2) high track drainage density (limited infiltration),3) high stream frequency (deep water-table) and 4) moderate to low bifurcation ratio. These sites are further characterized geologically and structurally

  9. Identifying diabetes knowledge network nodes as sites for a diabetes prevention program.

    Science.gov (United States)

    Gesler, Wilbert M; Arcury, Thomas A; Skelly, Anne H; Nash, Sally; Soward, April; Dougherty, Molly

    2006-12-01

    This paper reports on the methods used and results of a study that identified specific places within a community that have the potential to be sites for a diabetes prevention program. These sites, termed diabetes knowledge network nodes (DKNNs), are based on the concept of socio-spatial knowledge networks (SSKNs), the web of social relationships within which people obtain knowledge about type 2 diabetes. The target population for the study was working poor African Americans, Latinos, and European Americans of both sexes in a small rural southern town who had not been diagnosed with diabetes. Information was collected from a sample of 121 respondents on the places they visited in carrying out their daily activities. Data on number of visits to specific sites, degree of familiarity with these sites, and ratings of sites as places to receive diabetes information were used to develop three categories of DKNNs for six subgroups based on ethnicity and sex. Primary potential sites of importance to one or more subgroups included churches, grocery stores, drugstores, the local library, a beauty salon, laundromats, a community service agency, and a branch of the County Health Department. Secondary potential sites included gas stations, restaurants, banks, and post offices. Latent potential sites included three medical facilities. Most of the DKNNs were located either in the downtown area or in one of two shopping areas along the most used highway that passed through the town. The procedures used in this study can be generalized to other communities and prevention programs for other chronic diseases.

  10. Land Suitability Evaluation for Blueberry Crop by Determining the Qualitative Properties of the Identified Soil Type Related with the Antioxidant Capacity of Fruits

    Directory of Open Access Journals (Sweden)

    Amalia Ioana BOT

    2017-12-01

    Full Text Available Organic and inorganic forms of nitrogen and carbon were measured in order to determine soil fertility. The amount of total nitrogen ranged between 0.849 g/kg and 1.755 g/kg in the samples gathered from soil in modified state and between 0.961 k/kg and 2.427 g/kg in the samples collected from the soil in natural state. Based on these results it could be concluded that in comparing with the previous year, plants used the soil nutrients for their development. The activities of different enzymes were measured as well. Nitrate reductase activity was also higher in samples collected from soil in modified state (from bilon than in the samples collected near plantations (control samples and the values ranged between 0.055 ± 0.012 μmol⋅h-1⋅g-1 and 1.018 ± 0.117 μmol⋅h-1⋅g-1 in samples from soil in natural state and between 0.013 ± 0.002 μmol⋅h-1⋅g-1 and 0.447 ± 0.083 μmol⋅h-1⋅g-1 in bilons. Using GIS techniques of spatial analysis to determine the exact type of soil from each studied blueberry plantation from the Northwest Region of Development and also based on the soil bio-chemical analyses, it was possible to achieve a qualitative characterization of the territory, taking into account the requirements of blueberries for cultivation and to achieve a land suitability for blueberry crop. Combining laboratory approach, consisting from soil bio-chemical and physico-chemical analyses and chemical analyses of blueberry fruits, with the techniques used in order to determine the soil type and land suitability, the study conducted in the Northwest Region of Development identified the best conditions for blueberry crop, based on the qualitative characterization of land.

  11. SABER: a computational method for identifying active sites for new reactions.

    Science.gov (United States)

    Nosrati, Geoffrey R; Houk, K N

    2012-05-01

    A software suite, SABER (Selection of Active/Binding sites for Enzyme Redesign), has been developed for the analysis of atomic geometries in protein structures, using a geometric hashing algorithm (Barker and Thornton, Bioinformatics 2003;19:1644-1649). SABER is used to explore the Protein Data Bank (PDB) to locate proteins with a specific 3D arrangement of catalytic groups to identify active sites that might be redesigned to catalyze new reactions. As a proof-of-principle test, SABER was used to identify enzymes that have the same catalytic group arrangement present in o-succinyl benzoate synthase (OSBS). Among the highest-scoring scaffolds identified by the SABER search for enzymes with the same catalytic group arrangement as OSBS were L-Ala D/L-Glu epimerase (AEE) and muconate lactonizing enzyme II (MLE), both of which have been redesigned to become effective OSBS catalysts, demonstrated by experiments. Next, we used SABER to search for naturally existing active sites in the PDB with catalytic groups similar to those present in the designed Kemp elimination enzyme KE07. From over 2000 geometric matches to the KE07 active site, SABER identified 23 matches that corresponded to residues from known active sites. The best of these matches, with a 0.28 Å catalytic atom RMSD to KE07, was then redesigned to be compatible with the Kemp elimination using RosettaDesign. We also used SABER to search for potential Kemp eliminases using a theozyme predicted to provide a greater rate acceleration than the active site of KE07, and used Rosetta to create a design based on the proteins identified. Copyright © 2012 The Protein Society.

  12. Evaluation of potential regulatory elements identified as DNase I hypersensitive sites in the CFTR gene

    DEFF Research Database (Denmark)

    Phylactides, M.; Rowntree, R.; Nuthall, H.

    2002-01-01

    hypersensitive sites (DHS) within the locus. We previously identified at least 12 clusters of DHS across the CFTR gene and here further evaluate DHS in introns 2,3,10,16,17a, 18, 20 and 21 to assess their functional importance in regulation of CFTR gene expression. Transient transfections of enhancer/reporter...

  13. An investigation of the suitability of the Chalk River site to host a geologic waste management facility for CRL's low and intermediate level wastes

    International Nuclear Information System (INIS)

    Thompson, P.; Baumgartner, P.; Chan, T.; Kitson, C.; Kozak, E.; Man, A.; Martino, J.; Stroes-Gascoyne, S.; Beaton, D.; Sharp, K.; Thivierge, R.

    2011-01-01

    Atomic Energy of Canada Limited (AECL) is investigating the suitability of the Chalk River Laboratories (CRL) site for hosting a Geologic Waste Management Facility (GWMF) as part of the Nuclear Legacy Liabilities Program (NLLP) funded through Natural Resources Canada (NRCan). The GWMF is envisioned to be an underground engineered-geological repository consisting of shafts, access tunnels and emplacement caverns located at a nominal depth of 500 to 1000 m in the bedrock at the CRL site. A 5-year-long pre-project study was started in 2006 to assess the feasibility of the bedrock at the CRL site to host a GWMF. The pre-project feasibility study began with a review of various previous geological investigations performed in the bedrock at the CRL site. The 2006-2010 pre-project feasibility study involved exploring the geoscience and engineering characteristics of the bedrock to depths of over one kilometre at the CRL site through surface investigations and the drilling and testing of seven new deep characterization boreholes into the CRL bedrock. The collected information and interpretations were used to construct three-dimensional (3D) deterministic computer models of the geology of the bedrock at the CRL site and surrounding area and of the associated groundwater-flow regime. In order to technically assess the suitability of the CRL site, the GWMF feasibility study has conservatively assumed that all of the legacy and forecast Low and Intermediate Level Waste (LILW) at CRL would report to it. The 3D deterministic models were used within a preliminary performance and safety assessment model to assess the long-term safety of a hypothetical GWMF at the CRL site on the basis of future radionuclide and toxic substance releases. Other items important to a preliminary performance and safety assessment include an inventory of CRL's radioactive wastes and other contaminants that could be placed in the GWMF, the creation of the engineered waste emplacement rooms and

  14. Identifying protein phosphorylation sites with kinase substrate specificity on human viruses.

    Directory of Open Access Journals (Sweden)

    Neil Arvin Bretaña

    Full Text Available Viruses infect humans and progress inside the body leading to various diseases and complications. The phosphorylation of viral proteins catalyzed by host kinases plays crucial regulatory roles in enhancing replication and inhibition of normal host-cell functions. Due to its biological importance, there is a desire to identify the protein phosphorylation sites on human viruses. However, the use of mass spectrometry-based experiments is proven to be expensive and labor-intensive. Furthermore, previous studies which have identified phosphorylation sites in human viruses do not include the investigation of the responsible kinases. Thus, we are motivated to propose a new method to identify protein phosphorylation sites with its kinase substrate specificity on human viruses. The experimentally verified phosphorylation data were extracted from virPTM--a database containing 301 experimentally verified phosphorylation data on 104 human kinase-phosphorylated virus proteins. In an attempt to investigate kinase substrate specificities in viral protein phosphorylation sites, maximal dependence decomposition (MDD is employed to cluster a large set of phosphorylation data into subgroups containing significantly conserved motifs. The experimental human phosphorylation sites are collected from Phospho.ELM, grouped according to its kinase annotation, and compared with the virus MDD clusters. This investigation identifies human kinases such as CK2, PKB, CDK, and MAPK as potential kinases for catalyzing virus protein substrates as confirmed by published literature. Profile hidden Markov model is then applied to learn a predictive model for each subgroup. A five-fold cross validation evaluation on the MDD-clustered HMMs yields an average accuracy of 84.93% for Serine, and 78.05% for Threonine. Furthermore, an independent testing data collected from UniProtKB and Phospho.ELM is used to make a comparison of predictive performance on three popular kinase

  15. Identifying protein phosphorylation sites with kinase substrate specificity on human viruses.

    Science.gov (United States)

    Bretaña, Neil Arvin; Lu, Cheng-Tsung; Chiang, Chiu-Yun; Su, Min-Gang; Huang, Kai-Yao; Lee, Tzong-Yi; Weng, Shun-Long

    2012-01-01

    Viruses infect humans and progress inside the body leading to various diseases and complications. The phosphorylation of viral proteins catalyzed by host kinases plays crucial regulatory roles in enhancing replication and inhibition of normal host-cell functions. Due to its biological importance, there is a desire to identify the protein phosphorylation sites on human viruses. However, the use of mass spectrometry-based experiments is proven to be expensive and labor-intensive. Furthermore, previous studies which have identified phosphorylation sites in human viruses do not include the investigation of the responsible kinases. Thus, we are motivated to propose a new method to identify protein phosphorylation sites with its kinase substrate specificity on human viruses. The experimentally verified phosphorylation data were extracted from virPTM--a database containing 301 experimentally verified phosphorylation data on 104 human kinase-phosphorylated virus proteins. In an attempt to investigate kinase substrate specificities in viral protein phosphorylation sites, maximal dependence decomposition (MDD) is employed to cluster a large set of phosphorylation data into subgroups containing significantly conserved motifs. The experimental human phosphorylation sites are collected from Phospho.ELM, grouped according to its kinase annotation, and compared with the virus MDD clusters. This investigation identifies human kinases such as CK2, PKB, CDK, and MAPK as potential kinases for catalyzing virus protein substrates as confirmed by published literature. Profile hidden Markov model is then applied to learn a predictive model for each subgroup. A five-fold cross validation evaluation on the MDD-clustered HMMs yields an average accuracy of 84.93% for Serine, and 78.05% for Threonine. Furthermore, an independent testing data collected from UniProtKB and Phospho.ELM is used to make a comparison of predictive performance on three popular kinase-specific phosphorylation site

  16. Identifying potential surface water sampling sites for emerging chemical pollutants in Gauteng Province, South Africa

    OpenAIRE

    Petersen, F; Dabrowski, JM; Forbes, PBC

    2017-01-01

    Emerging chemical pollutants (ECPs) are defined as new chemicals which do not have a regulatory status, but which may have an adverse effect on human health and the environment. The occurrence and concentrations of ECPs in South African water bodies are largely unknown, so monitoring is required in order to determine the potential threat that these ECPs may pose. Relevant surface water sampling sites in the Gauteng Province of South Africa were identified utilising a geographic information sy...

  17. A model-based approach to identify binding sites in CLIP-Seq data.

    Directory of Open Access Journals (Sweden)

    Tao Wang

    Full Text Available Cross-linking immunoprecipitation coupled with high-throughput sequencing (CLIP-Seq has made it possible to identify the targeting sites of RNA-binding proteins in various cell culture systems and tissue types on a genome-wide scale. Here we present a novel model-based approach (MiClip to identify high-confidence protein-RNA binding sites from CLIP-seq datasets. This approach assigns a probability score for each potential binding site to help prioritize subsequent validation experiments. The MiClip algorithm has been tested in both HITS-CLIP and PAR-CLIP datasets. In the HITS-CLIP dataset, the signal/noise ratios of miRNA seed motif enrichment produced by the MiClip approach are between 17% and 301% higher than those by the ad hoc method for the top 10 most enriched miRNAs. In the PAR-CLIP dataset, the MiClip approach can identify ∼50% more validated binding targets than the original ad hoc method and two recently published methods. To facilitate the application of the algorithm, we have released an R package, MiClip (http://cran.r-project.org/web/packages/MiClip/index.html, and a public web-based graphical user interface software (http://galaxy.qbrc.org/tool_runner?tool_id=mi_clip for customized analysis.

  18. A GIS-based approach for identifying potential runoff harvesting sites in the Thukela River basin, South Africa

    Science.gov (United States)

    de Winnaar, G.; Jewitt, G. P. W.; Horan, M.

    Water scarce countries such as South Africa are subject to various hydrological constraints which can often be attributed to poor rainfall partitioning, particularly within resource poor farming communities that are reliant on rainfed agriculture. Recent initiatives to address this have shifted focus to explore more efficient alternatives to water supply and the recognition of numerous opportunities to implement runoff harvesting as a means to supplement water availability. However, increasing the implementation of runoff harvesting, without encountering unintended impacts on downstream hydrological and ecological systems, requires better understanding of the hydrologic and environmental impacts at catchment scale. In this paper the representation of spatial variations in landscape characteristics such as soil, land use, rainfall and slope information is shown to be an important step in identifying potential runoff harvesting sites, after which modelling the hydrological response in catchments where extensive runoff harvesting is being considered can be performed and likely impacts assessed. Geographic information systems (GIS) was utilised as an integrating tool to store, analyse and manage spatial information and when linked to hydrological response models, provided a rational means to facilitate decision making by providing catchment level identification, planning and assessment of runoff harvesting sites as illustrated by a case study at the Potshini catchment, a small sub-catchment in the Thukela River basin, South Africa. Through the linked GIS, potential runoff harvesting sites are identified relative to areas that concentrate runoff and where the stored water will be appropriately distributed. Based on GIS analysis it was found that 17% percent of the Potshini catchment area has a high potential for generating surface runoff, whereas an analysis of all factors which influence the location of such systems, shows that 18% is highly suitable for runoff

  19. GIS and Multi Criteria Decision Method Based Approach of Identifying Appropriate Landfill Sites for the City Of Chittagong

    Directory of Open Access Journals (Sweden)

    M. Ali Ashraf

    2015-02-01

    were identified initially. Out of these sites four were found to be most appropriate and suitable for use as landfill. DOI: http://dx.doi.org/10.3126/ije.v4i1.12174International Journal of Environment Volume-4, Issue-1, Dec-Feb 2014/15, page: 1-15  

  20. A Framework for Statewide Analysis of Site Suitability, Energy Estimation, Life Cycle Costs, Financial Feasibility and Environmental Assessment of Wind Farms: A Case Study of Indiana

    Science.gov (United States)

    Kumar, Indraneel

    In the last decade, Midwestern states including Indiana have experienced an unprecedented growth in utility scale wind energy farms. For example, by end of 2013, Indiana had 1.5 GW of wind turbines installed, which could provide electrical energy for as many as half-a-million homes. However, there is no statewide systematic framework available for the evaluation of wind farm impacts on endangered species, required necessary setbacks and proximity standards to infrastructure, and life cycle costs. This research is guided to fill that gap and it addresses the following questions. How much land is suitable for wind farm siting in Indiana given the constraints of environmental, ecological, cultural, settlement, physical infrastructure and wind resource parameters? How much wind energy can be obtained? What are the life cycle costs and economic and financial feasibility? Is wind energy production and development in a state an emission free undertaking? The framework developed in the study is applied to a case study of Indiana. A fuzzy logic based AHP (Analytic Hierarchy Process) spatial site suitability analysis for wind energy is formulated. The magnitude of wind energy that could be sited and installed comprises input for economic and financial feasibility analysis for 20-25 years life cycle of wind turbines in Indiana. Monte Carlo simulation is used to account for uncertainty and nonlinearity in various costs and price parameters. Impacts of incentives and cost variables such as production tax credits, costs of capital, and economies of scale are assessed. Further, an economic input-output (IO) based environmental assessment model is developed for wind energy, where costs from financial feasibility analysis constitute the final demand vectors. This customized model for Indiana is used to assess emissions for criteria air pollutants, hazardous air pollutants and greenhouse gases (GHG) across life cycle events of wind turbines. The findings of the case study include

  1. Hon-yaku: a biology-driven Bayesian methodology for identifying translation initiation sites in prokaryotes

    Directory of Open Access Journals (Sweden)

    de Hoon Michiel JL

    2007-02-01

    Full Text Available Abstract Background Computational prediction methods are currently used to identify genes in prokaryote genomes. However, identification of the correct translation initiation sites remains a difficult task. Accurate translation initiation sites (TISs are important not only for the annotation of unknown proteins but also for the prediction of operons, promoters, and small non-coding RNA genes, as this typically makes use of the intergenic distance. A further problem is that most existing methods are optimized for Escherichia coli data sets; applying these methods to newly sequenced bacterial genomes may not result in an equivalent level of accuracy. Results Based on a biological representation of the translation process, we applied Bayesian statistics to create a score function for predicting translation initiation sites. In contrast to existing programs, our combination of methods uses supervised learning to optimally use the set of known translation initiation sites. We combined the Ribosome Binding Site (RBS sequence, the distance between the translation initiation site and the RBS sequence, the base composition of the start codon, the nucleotide composition (A-rich sequences following start codons, and the expected distribution of the protein length in a Bayesian scoring function. To further increase the prediction accuracy, we also took into account the operon orientation. The outcome of the procedure achieved a prediction accuracy of 93.2% in 858 E. coli genes from the EcoGene data set and 92.7% accuracy in a data set of 1243 Bacillus subtilis 'non-y' genes. We confirmed the performance in the GC-rich Gamma-Proteobacteria Herminiimonas arsenicoxydans, Pseudomonas aeruginosa, and Burkholderia pseudomallei K96243. Conclusion Hon-yaku, being based on a careful choice of elements important in translation, improved the prediction accuracy in B. subtilis data sets and other bacteria except for E. coli. We believe that most remaining

  2. Suitability of PCR fingerprinting, infrequent-restriction-site PCR, and pulsed-field gel electrophoresis, combined with computerized gel analysis, in library typing of Salmonella enterica serovar enteritidis

    DEFF Research Database (Denmark)

    Garaizar, J.; Lopez-Molina, N.; Laconcha, I.

    2000-01-01

    Strains of Salmonella enterica (n = 212) of different serovars and phage types were used to establish a library typing computerized system for serovar Enteritidis on the basis of PCR fingerprinting, infrequent-restriction-site PCR (IRS-PCR), or pulsed-field gel electrophoresis (PFGE). The rate...... showed an intercenter reproducibility value of 93.3%. The high reproducibility of PFGE combined with the previously determined high discrimination directed its use for library typing. The use of PFGE with enzymes XbaI, BlnI, and SpeI for library typing of serovar Enteritidis was assessed with GelCompar 4.......0 software, Three computer libraries of PFGE DNA profiles were constructed, and their ability to recognize new DNA profiles was analyzed. The results obtained pointed out that the combination of PFGE with computerized analysis could be suitable in long-term epidemiological comparison and surveillance...

  3. Assessment of the horizontal transfer of functional genes as a suitable approach for evaluation of the bioremediation potential of petroleum-contaminated sites: a mini-review.

    Science.gov (United States)

    Shahi, Aiyoub; Ince, Bahar; Aydin, Sevcan; Ince, Orhan

    2017-06-01

    Petroleum sludge contains recalcitrant residuals. These compounds because of being toxic to humans and other organism are of the major concerns. Therefore, petroleum sludge should be safely disposed. Physicochemical methods which are used by this sector are mostly expensive and need complex devices. Bioremediation methods because of being eco-friendly and cost-effective overcome most of the limitations of physicochemical treatments. Microbial strains capable to degrade petroleum hydrocarbons are practically present in all soils and sediments and their population density increases in contact with contaminants. Bacterial strains cannot degrade alone all kinds of petroleum hydrocarbons, rather microbial consortium should collaborate with each other for degradation of petroleum hydrocarbon mixtures. Horizontal transfer of functional genes between bacteria plays an important role in increasing the metabolic potential of the microbial community. Therefore, selecting a suitable degrading gene and tracking its horizontal transfer would be a useful approach to evaluate the bioremediation process and to assess the bioremediation potential of contaminated sites.

  4. Common integration sites of published datasets identified using a graph-based framework

    Directory of Open Access Journals (Sweden)

    Alessandro Vasciaveo

    2016-01-01

    Full Text Available With next-generation sequencing, the genomic data available for the characterization of integration sites (IS has dramatically increased. At present, in a single experiment, several thousand viral integration genome targets can be investigated to define genomic hot spots. In a previous article, we renovated a formal CIS analysis based on a rigid fixed window demarcation into a more stretchy definition grounded on graphs. Here, we present a selection of supporting data related to the graph-based framework (GBF from our previous article, in which a collection of common integration sites (CIS was identified on six published datasets. In this work, we will focus on two datasets, ISRTCGD and ISHIV, which have been previously discussed. Moreover, we show in more detail the workflow design that originates the datasets.

  5. A method of identifying social structures in siting regions for deep geological repositories in Switzerland

    International Nuclear Information System (INIS)

    Brander, Simone

    2010-09-01

    Acceptance is a key element in the site selection process for deep geological repositories for high-level and low and intermediate-level radioactive waste in Switzerland. Participation requirements such as comprehensive negotiation issues and adequate resources have thus been defined by the Swiss Federal Office of Energy (SFOE). In 2008, on the basis of technical criteria Nagra (National Cooperative for the Disposal of Radioactive Waste) proposed several potential areas for deep geological repositories. The number of potential areas will be narrowed down within the next few years. All municipalities within the planning perimeter (the area in which surface facilities can be realised) are affected and form the siting region. In order to ensure that the local population have their say in the forthcoming discussions, regional participation bodies including all municipalities within a siting region are being set up by the SFOE. Regional participation ensures that local interests, needs and values are taken into account in the site selection process. Assembling the regional participation bodies is therefore of great importance. Before such bodies can be formed, however, the various interests, needs and values have to be identified, and special attention has to be paid to long-term interests of future generations, as well as to non-organised and under-represented interests. According to the concept of proportional representation, the interests, needs and values that are identified and weighted by the local population are to be represented in the regional participation procedure. The aim of this study is to share a method of mapping existing social structures in a defined geographical area. This involves a combination of an analysis of socio-economic statistical data and qualitative and quantitative social research methods

  6. SNOSite: exploiting maximal dependence decomposition to identify cysteine S-nitrosylation with substrate site specificity.

    Directory of Open Access Journals (Sweden)

    Tzong-Yi Lee

    Full Text Available S-nitrosylation, the covalent attachment of a nitric oxide to (NO the sulfur atom of cysteine, is a selective and reversible protein post-translational modification (PTM that regulates protein activity, localization, and stability. Despite its implication in the regulation of protein functions and cell signaling, the substrate specificity of cysteine S-nitrosylation remains unknown. Based on a total of 586 experimentally identified S-nitrosylation sites from SNAP/L-cysteine-stimulated mouse endothelial cells, this work presents an informatics investigation on S-nitrosylation sites including structural factors such as the flanking amino acids composition, the accessible surface area (ASA and physicochemical properties, i.e. positive charge and side chain interaction parameter. Due to the difficulty to obtain the conserved motifs by conventional motif analysis, maximal dependence decomposition (MDD has been applied to obtain statistically significant conserved motifs. Support vector machine (SVM is applied to generate predictive model for each MDD-clustered motif. According to five-fold cross-validation, the MDD-clustered SVMs could achieve an accuracy of 0.902, and provides a promising performance in an independent test set. The effectiveness of the model was demonstrated on the correct identification of previously reported S-nitrosylation sites of Bos taurus dimethylarginine dimethylaminohydrolase 1 (DDAH1 and human hemoglobin subunit beta (HBB. Finally, the MDD-clustered model was adopted to construct an effective web-based tool, named SNOSite (http://csb.cse.yzu.edu.tw/SNOSite/, for identifying S-nitrosylation sites on the uncharacterized protein sequences.

  7. GSHSite: exploiting an iteratively statistical method to identify s-glutathionylation sites with substrate specificity.

    Directory of Open Access Journals (Sweden)

    Yi-Ju Chen

    Full Text Available S-glutathionylation, the covalent attachment of a glutathione (GSH to the sulfur atom of cysteine, is a selective and reversible protein post-translational modification (PTM that regulates protein activity, localization, and stability. Despite its implication in the regulation of protein functions and cell signaling, the substrate specificity of cysteine S-glutathionylation remains unknown. Based on a total of 1783 experimentally identified S-glutathionylation sites from mouse macrophages, this work presents an informatics investigation on S-glutathionylation sites including structural factors such as the flanking amino acids composition and the accessible surface area (ASA. TwoSampleLogo presents that positively charged amino acids flanking the S-glutathionylated cysteine may influence the formation of S-glutathionylation in closed three-dimensional environment. A statistical method is further applied to iteratively detect the conserved substrate motifs with statistical significance. Support vector machine (SVM is then applied to generate predictive model considering the substrate motifs. According to five-fold cross-validation, the SVMs trained with substrate motifs could achieve an enhanced sensitivity, specificity, and accuracy, and provides a promising performance in an independent test set. The effectiveness of the proposed method is demonstrated by the correct identification of previously reported S-glutathionylation sites of mouse thioredoxin (TXN and human protein tyrosine phosphatase 1b (PTP1B. Finally, the constructed models are adopted to implement an effective web-based tool, named GSHSite (http://csb.cse.yzu.edu.tw/GSHSite/, for identifying uncharacterized GSH substrate sites on the protein sequences.

  8. Computerized analysis of the 12-lead electrocardiogram to identify epicardial ventricular tachycardia exit sites.

    Science.gov (United States)

    Yokokawa, Miki; Jung, Dae Yon; Joseph, Kim K; Hero, Alfred O; Morady, Fred; Bogun, Frank

    2014-11-01

    Twelve-lead electrocardiogram (ECG) criteria for epicardial ventricular tachycardia (VT) origins have been described. In patients with structural heart disease, the ability to predict an epicardial origin based on QRS morphology is limited and has been investigated only for limited regions in the heart. The purpose of this study was to determine whether a computerized algorithm is able to accurately differentiate epicardial vs endocardial origins of ventricular arrhythmias. Endocardial and epicardial pace-mapping were performed in 43 patients at 3277 sites. The 12-lead ECGs were digitized and analyzed using a mixture of gaussian model (MoG) to assess whether the algorithm was able to identify an epicardial vs endocardial origin of the paced rhythm. The MoG computerized algorithm was compared to algorithms published in prior reports. The computerized algorithm correctly differentiated epicardial vs endocardial pacing sites for 80% of the sites compared to an accuracy of 42% to 66% of other described criteria. The accuracy was higher in patients without structural heart disease than in those with structural heart disease (94% vs 80%, P = .0004) and for right bundle branch block (82%) compared to left bundle branch block morphologies (79%, P = .001). Validation studies showed the accuracy for VT exit sites to be 84%. A computerized algorithm was able to accurately differentiate the majority of epicardial vs endocardial pace-mapping sites. The algorithm is not region specific and performed best in patients without structural heart disease and with VTs having a right bundle branch block morphology. Copyright © 2014 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.

  9. Challenges in identifying sites climatically matched to the native ranges of animal invaders

    Science.gov (United States)

    Rodda, G.H.; Jarnevich, C.S.; Reed, R.N.

    2011-01-01

    Background: Species distribution models are often used to characterize a species' native range climate, so as to identify sites elsewhere in the world that may be climatically similar and therefore at risk of invasion by the species. This endeavor provoked intense public controversy over recent attempts to model areas at risk of invasion by the Indian Python (Python molurus). We evaluated a number of MaxEnt models on this species to assess MaxEnt's utility for vertebrate climate matching. Methodology/Principal Findings: Overall, we found MaxEnt models to be very sensitive to modeling choices and selection of input localities and background regions. As used, MaxEnt invoked minimal protections against data dredging, multi-collinearity of explanatory axes, and overfitting. As used, MaxEnt endeavored to identify a single ideal climate, whereas different climatic considerations may determine range boundaries in different parts of the native range. MaxEnt was extremely sensitive to both the choice of background locations for the python, and to selection of presence points: inclusion of just four erroneous localities was responsible for Pyron et al.'s conclusion that no additional portions of the U.S. mainland were at risk of python invasion. When used with default settings, MaxEnt overfit the realized climate space, identifying models with about 60 parameters, about five times the number of parameters justifiable when optimized on the basis of Akaike's Information Criterion. Conclusions/Significance: When used with default settings, MaxEnt may not be an appropriate vehicle for identifying all sites at risk of colonization. Model instability and dearth of protections against overfitting, multi-collinearity, and data dredging may combine with a failure to distinguish fundamental from realized climate envelopes to produce models of limited utility. A priori identification of biologically realistic model structure, combined with computational protections against these

  10. Challenges in identifying sites climatically matched to the native ranges of animal invaders.

    Directory of Open Access Journals (Sweden)

    Gordon H Rodda

    Full Text Available BACKGROUND: Species distribution models are often used to characterize a species' native range climate, so as to identify sites elsewhere in the world that may be climatically similar and therefore at risk of invasion by the species. This endeavor provoked intense public controversy over recent attempts to model areas at risk of invasion by the Indian Python (Python molurus. We evaluated a number of MaxEnt models on this species to assess MaxEnt's utility for vertebrate climate matching. METHODOLOGY/PRINCIPAL FINDINGS: Overall, we found MaxEnt models to be very sensitive to modeling choices and selection of input localities and background regions. As used, MaxEnt invoked minimal protections against data dredging, multi-collinearity of explanatory axes, and overfitting. As used, MaxEnt endeavored to identify a single ideal climate, whereas different climatic considerations may determine range boundaries in different parts of the native range. MaxEnt was extremely sensitive to both the choice of background locations for the python, and to selection of presence points: inclusion of just four erroneous localities was responsible for Pyron et al.'s conclusion that no additional portions of the U.S. mainland were at risk of python invasion. When used with default settings, MaxEnt overfit the realized climate space, identifying models with about 60 parameters, about five times the number of parameters justifiable when optimized on the basis of Akaike's Information Criterion. CONCLUSIONS/SIGNIFICANCE: When used with default settings, MaxEnt may not be an appropriate vehicle for identifying all sites at risk of colonization. Model instability and dearth of protections against overfitting, multi-collinearity, and data dredging may combine with a failure to distinguish fundamental from realized climate envelopes to produce models of limited utility. A priori identification of biologically realistic model structure, combined with computational protections

  11. Challenges in identifying sites climatically matched to the native ranges of animal invaders.

    Science.gov (United States)

    Rodda, Gordon H; Jarnevich, Catherine S; Reed, Robert N

    2011-02-09

    Species distribution models are often used to characterize a species' native range climate, so as to identify sites elsewhere in the world that may be climatically similar and therefore at risk of invasion by the species. This endeavor provoked intense public controversy over recent attempts to model areas at risk of invasion by the Indian Python (Python molurus). We evaluated a number of MaxEnt models on this species to assess MaxEnt's utility for vertebrate climate matching. Overall, we found MaxEnt models to be very sensitive to modeling choices and selection of input localities and background regions. As used, MaxEnt invoked minimal protections against data dredging, multi-collinearity of explanatory axes, and overfitting. As used, MaxEnt endeavored to identify a single ideal climate, whereas different climatic considerations may determine range boundaries in different parts of the native range. MaxEnt was extremely sensitive to both the choice of background locations for the python, and to selection of presence points: inclusion of just four erroneous localities was responsible for Pyron et al.'s conclusion that no additional portions of the U.S. mainland were at risk of python invasion. When used with default settings, MaxEnt overfit the realized climate space, identifying models with about 60 parameters, about five times the number of parameters justifiable when optimized on the basis of Akaike's Information Criterion. When used with default settings, MaxEnt may not be an appropriate vehicle for identifying all sites at risk of colonization. Model instability and dearth of protections against overfitting, multi-collinearity, and data dredging may combine with a failure to distinguish fundamental from realized climate envelopes to produce models of limited utility. A priori identification of biologically realistic model structure, combined with computational protections against these statistical problems, may produce more robust models of invasion risk.

  12. Development of a specific methodology to assess suitable sites to receive a repository for L/ILW waste in the Portuguese territory

    Energy Technology Data Exchange (ETDEWEB)

    Paiva, Isabel [Instituto Superior Tecnico, Nuclear and Technological Campus, Technical, University of Lisbon, Estrada Nacional N10 - km 139,7, 2695-066, Bobadela LRS (Portugal); Trindade, Romao B. [MedicalConsult,S.A., Campo Grande, no. 56, 8A, 1700-093, Lisboa (Portugal); Goncalves, Mario A. [University of Lisbon, Faculty of Sciences, Dept. Geology and CREMINER-ISR/LA, Ed. C6, 4, 1749-016 Lisbon (Portugal); Mateus, Antonio [University of Lisbon, Faculty of Sciences, Dept. Geology and CeGUL, Ed. C6, 4, 1749-016 Lisbon (Portugal)

    2013-07-01

    Portugal does not have nuclear power plants but records an increasing production of radioactive waste from medical, industrial and research applications of radioactive materials in the form of sealed and unsealed sources; the country totals include also the spent fuel of one nuclear reactor for research purposes. Since radioactive waste management policies and practices in Portugal will have to comply with the Council Directive 2011/70/Euratom and the IAEA Joint Convention, the search for scientific and technological solutions to deal with radioactive wastes produced in the country started some years ago. The research carried out recently under the scope of a national funded project (KADRWaste, PTDC/CTEGEX/ 82678/2006) represents a firm step in this commitment. Indeed, the transfer of methodologies tested and validated in this project allowed for improvement to a procedure to assess suitable sites to receive a near-surface repository for 'Low and Intermediate Level Waste, Short Live and Long Live' (LILWSL, LL) wastes in Portugal mainland. Although the main stages of the procedure can be of universal usage, details were designed according to the intrinsic geological, geomorphic and meteorological features of previously selected target-areas. All the requirements exhaustively listed in many reports of the IAEA were fulfilled and, in addition, the application of mineralogical, geochemical and textural criteria is strongly advised. The proposed procedure is based on a 5 key-steps approach preceded by clarification of the boundary conditions to be imposed, which are crucial to the inventory of various compulsory technical requirements. This analysis requires the adoption of stringent criteria, many of them of multidisciplinary nature, including tests of vulnerability and assessment of uncertainty, besides the environmental impact risk. As a result, priority targets that are not excluded will integrate different classes and, depending on the existing knowledge

  13. Development of a specific methodology to assess suitable sites to receive a repository for L/ILW waste in the Portuguese territory

    International Nuclear Information System (INIS)

    Paiva, Isabel; Trindade, Romao B.; Goncalves, Mario A.; Mateus, Antonio

    2013-01-01

    Portugal does not have nuclear power plants but records an increasing production of radioactive waste from medical, industrial and research applications of radioactive materials in the form of sealed and unsealed sources; the country totals include also the spent fuel of one nuclear reactor for research purposes. Since radioactive waste management policies and practices in Portugal will have to comply with the Council Directive 2011/70/Euratom and the IAEA Joint Convention, the search for scientific and technological solutions to deal with radioactive wastes produced in the country started some years ago. The research carried out recently under the scope of a national funded project (KADRWaste, PTDC/CTEGEX/ 82678/2006) represents a firm step in this commitment. Indeed, the transfer of methodologies tested and validated in this project allowed for improvement to a procedure to assess suitable sites to receive a near-surface repository for 'Low and Intermediate Level Waste, Short Live and Long Live' (LILWSL, LL) wastes in Portugal mainland. Although the main stages of the procedure can be of universal usage, details were designed according to the intrinsic geological, geomorphic and meteorological features of previously selected target-areas. All the requirements exhaustively listed in many reports of the IAEA were fulfilled and, in addition, the application of mineralogical, geochemical and textural criteria is strongly advised. The proposed procedure is based on a 5 key-steps approach preceded by clarification of the boundary conditions to be imposed, which are crucial to the inventory of various compulsory technical requirements. This analysis requires the adoption of stringent criteria, many of them of multidisciplinary nature, including tests of vulnerability and assessment of uncertainty, besides the environmental impact risk. As a result, priority targets that are not excluded will integrate different classes and, depending on the existing knowledge

  14. FIGIFIGO as a tool to characterize and identify planetary analogue sites

    Science.gov (United States)

    Gritsevich, M.; Peltoniemi, J.; Hakala, T.; Muinonen, K.

    2014-07-01

    We present an overview of the Finnish Geodetic Institute's field goniospectrometer (FIGIFIGO) and highlight its usability to study extraterrestrial analogues on the Earth. The design concept of this custom-made instrument has been proved to have a number of advantages, such as a well-adopted user-friendly interface, a high level of automation, and excellent suitability for field measurements within a wide range of weather conditions. It is perfect for collection of reference data on a given target in natural undisturbed (and well-recorded for further data interpretation) conditions. The instrument communicates via a controlled computer with an implemented simple and user-friendly interface. This allows users to easily set up optional parameters at the beginning of the measurement series. Thus a number of details may be modified, such as the initial position of the sensor, the range and speed of further automated zenith turns, and length of the turnable arm holding the selected optics (including an option for a computer-turned linear polarizer) above the target. The assembly and operation of the instrument are fast and efficient in both laboratory and field conditions. It is battery powered and easily portable, including possible transportation by plane, car, boat, or sledge. The system includes a sky camera to detect the goniometer orientation and a pyranometer to monitor the actual illumination conditions. A fine-tune mirror is used for spatial correction of the optics footprint. Recent calibration of the system has significantly increased the measurement robustness and data reliability, and has provided the operators with information on how to operate the instrument in the most efficient and accurate way. Measurement campaigns are organized frequently and significant amount of reference data has been already collected. The identification of new planetary analogue sites and characterization of known ones using FIGIFIGO could offer new possibilities and provide

  15. SCS-CN and GIS-based approach for identifying potential water harvesting sites in the Kali Watershed, Mahi River Basin, India

    Science.gov (United States)

    Ramakrishnan, D.; Bandyopadhyay, A.; Kusuma, K. N.

    2009-08-01

    The Kali sub-watershed is situated in the semi-arid region of Gujarat, India and forms a part of the Mahi River Watershed. This watershed receives an average annual rainfall of 900mm mainly between July and September. Due to high runoff potential, evapo-transpiration and poor infiltration, drought like situation prevails in this area from December to June almost every year. In this paper, augmentation of water resource is proposed by construction of runoff harvesting structures like check dam, percolation pond, farm pond, well and subsurface dyke. The site suitability for different water harvesting structures is determined by considering spatially varying parameters like runoff potential, slope, fracture pattern and micro-watershed area. GIS is utilised as a tool to store, analyse and integrate spatial and attribute information pertaining to runoff, slope, drainage and fracture. The runoff derived by SCS-CN method is a function of runoff potential which can be expressed in terms of runoff coefficient (ratio between the runoff and rainfall) which can be classified into three classes, viz., high (>40%), moderate (20-40%) and low (<20%). In addition to IMSD, FAO specifications for water harvesting/recharging structures, parameters such as effective storage, rock mass permeability are herein considered to augment effective storage. Using the overlay and decision tree concepts in GIS, potential water harvesting sites are identified. The derived sites are field investigated for suitability and implementation. In all, the accuracy of the site selection at implementation level varies from 80-100%.

  16. Using questions sent to an Ask-A-Scientist site to identify children's interests in science

    Science.gov (United States)

    Baram-Tsabari, Ayelet; Sethi, Ricky J.; Bry, Lynn; Yarden, Anat

    2006-11-01

    Interest is a powerful motivator; nonetheless, science educators often lack the necessary information to make use of the power of student-specific interests in the reform process of science curricula. This study suggests a novel methodology, which might be helpful in identifying such interests - using children's self-generated questions as an indication of their scientific interests. In this research, children's interests were measured by analyzing 1555 science-related questions submitted to an international Ask-A-Scientist Internet site. The analysis indicated that the popularity of certain topics varies with age and gender. Significant differences were found between children's spontaneous (intrinsically motivated) and school-related (extrinsically motivated) interests. Surprisingly, girls contributed most of the questions to the sample; however, the number of American girls dropped upon entering senior high school. We also found significant differences between girls' and boys' interests, with girls generally preferring biological topics. The two genders kept to their stereotypic fields of interest, in both their school-related and spontaneous questions. Children's science interests, as inferred from questions to Web sites, could ultimately inform classroom science teaching. This methodology extends the context in which children's interests can be investigated.

  17. Identifying malaria hotspots in Keur Soce health and demographic surveillance site in context of low transmission.

    Science.gov (United States)

    Ndiath, Mansour; Faye, Babacar; Cisse, Badara; Ndiaye, Jean Louis; Gomis, Jules François; Dia, Anta Tal; Gaye, Oumar

    2014-11-24

    Malaria is major public health problem in Senegal. In some parts of the country, it occurs almost permanently with a seasonal increase during the rainy season. There is evidence to suggest that the prevalence of malaria in Senegal has decreased considerably during the past few years. Recent data from the Senegalese National Malaria Control Programme (NMCP) indicates that the number of malaria cases decrease from 1,500,000 in 2006 to 174,339 in 2010. With the decline of malaria morbidity in Senegal, the characterization of the new epidemiological profile of this disease is crucial for public health decision makers. SaTScan™ software using the Kulldorf method of retrospective space-time permutation and the Bernoulli purely spatial model was used to identify malaria clusters using confirmed malaria cases in 74 villages. ArcMAp was used to map malaria hotspots. Logistic regression was used to investigate risk factors for malaria hotspots in Keur Soce health and demographic surveillance site. A total of 1,614 individuals in 440 randomly selected households were enrolled. The overall malaria prevalence was 12%. The malaria prevalence during the study period varied from less than 2% to more than 25% from one village to another. The results showed also that rooms located between 50 m to 100 m away from livestock holding place [adjusted O.R = 0.7, P = 0.044, 95% C.I (1.02 - 7.42)], bed net use [adjusted O.R = 1.2, P = 0.024, 95% C.I (1.02 -1.48)], are good predictors for malaria hotspots in the Keur Soce health and demographic surveillance site. The socio economic status of the household also predicted on hotspots patterns. The less poor household are 30% less likely to be classified as malaria hotspots area compared to the poorest household [adjusted O.R = 0.7, P = 0.014, 95% C.I (0.47 - 0.91)]. The study investigated risk factors for malaria hotspots in small communities in the Keur Soce site. The result showed considerable variation of malaria

  18. Identifying functional transcription factor binding sites in yeast by considering their positional preference in the promoters.

    Directory of Open Access Journals (Sweden)

    Fu-Jou Lai

    Full Text Available Transcription factor binding site (TFBS identification plays an important role in deciphering gene regulatory codes. With comprehensive knowledge of TFBSs, one can understand molecular mechanisms of gene regulation. In the recent decades, various computational approaches have been proposed to predict TFBSs in the genome. The TFBS dataset of a TF generated by each algorithm is a ranked list of predicted TFBSs of that TF, where top ranked TFBSs are statistically significant ones. However, whether these statistically significant TFBSs are functional (i.e. biologically relevant is still unknown. Here we develop a post-processor, called the functional propensity calculator (FPC, to assign a functional propensity to each TFBS in the existing computationally predicted TFBS datasets. It is known that functional TFBSs reveal strong positional preference towards the transcriptional start site (TSS. This motivates us to take TFBS position relative to the TSS as the key idea in building our FPC. Based on our calculated functional propensities, the TFBSs of a TF in the original TFBS dataset could be reordered, where top ranked TFBSs are now the ones with high functional propensities. To validate the biological significance of our results, we perform three published statistical tests to assess the enrichment of Gene Ontology (GO terms, the enrichment of physical protein-protein interactions, and the tendency of being co-expressed. The top ranked TFBSs in our reordered TFBS dataset outperform the top ranked TFBSs in the original TFBS dataset, justifying the effectiveness of our post-processor in extracting functional TFBSs from the original TFBS dataset. More importantly, assigning functional propensities to putative TFBSs enables biologists to easily identify which TFBSs in the promoter of interest are likely to be biologically relevant and are good candidates to do further detailed experimental investigation. The FPC is implemented as a web tool at http://santiago.ee.ncku.edu.tw/FPC/.

  19. Development of an accident consequence assessment code for evaluating site suitability of light- and heavy-water reactors based on the Korean Technical standards

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Won Tae; Jeong, Hae Sung; Jeong, Hyo Joon; Kil, A Reum; Kim, Eun Han; Han, Moon Hee [Nuclear Environment Safety Research Division, Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2016-12-15

    Methodologies for a series of radiological consequence assessments show a distinctive difference according to the design principles of the original nuclear suppliers and their technical standards to be imposed. This is due to the uncertainties of the accidental source term, radionuclide behavior in the environment, and subsequent radiological dose. Both types of PWR and PHWR are operated in Korea. However, technical standards for evaluating atmospheric dispersion have been enacted based on the U.S. NRC's positions regardless of the reactor types. For this reason, it might cause a controversy between the licensor and licensee of a nuclear power plant. It was modelled under the framework of the NRC Regulatory Guide 1.145 for light-water reactors, reflecting the features of heavy-water reactors as specified in the Canadian National Standard and the modelling features in MACCS2, such as atmospheric diffusion coefficient, ground deposition, surface roughness, radioactive plume depletion, and exposure from ground deposition. An integrated accident consequence assessment code, ACCESS (Accident Consequence Assessment Code for Evaluating Site Suitability), was developed by taking into account the unique regulatory positions for reactor types under the framework of the current Korean technical standards. Field tracer experiments and hand calculations have been carried out for validation and verification of the models. The modelling approaches of ACCESS and its features are introduced, and its applicative results for a hypothetical accidental scenario are comprehensively discussed. In an applicative study, the predicted results by the light-water reactor assessment model were higher than those by other models in terms of total doses.

  20. Dipeptide frequency/bias analysis identifies conserved sites of nonrandomness shared by cysteine-rich motifs.

    Science.gov (United States)

    Campion, S R; Ameen, A S; Lai, L; King, J M; Munzenmaier, T N

    2001-08-15

    This report describes the application of a simple computational tool, AAPAIR.TAB, for the systematic analysis of the cysteine-rich EGF, Sushi, and Laminin motif/sequence families at the two-amino acid level. Automated dipeptide frequency/bias analysis detects preferences in the distribution of amino acids in established protein families, by determining which "ordered dipeptides" occur most frequently in comprehensive motif-specific sequence data sets. Graphic display of the dipeptide frequency/bias data revealed family-specific preferences for certain dipeptides, but more importantly detected a shared preference for employment of the ordered dipeptides Gly-Tyr (GY) and Gly-Phe (GF) in all three protein families. The dipeptide Asn-Gly (NG) also exhibited high-frequency and bias in the EGF and Sushi motif families, whereas Asn-Thr (NT) was distinguished in the Laminin family. Evaluation of the distribution of dipeptides identified by frequency/bias analysis subsequently revealed the highly restricted localization of the G(F/Y) and N(G/T) sequence elements at two separate sites of extreme conservation in the consensus sequence of all three sequence families. The similar employment of the high-frequency/bias dipeptides in three distinct protein sequence families was further correlated with the concurrence of these shared molecular determinants at similar positions within the distinctive scaffolds of three structurally divergent, but similarly employed, motif modules.

  1. Preliminary geological suitability assessment for LILW disposal

    International Nuclear Information System (INIS)

    Tomse, P.; Mele, I.

    2001-01-01

    outcome of this stage a number of potentially suitable areas is expected. The final confirmation of site suitability will be gained by detailed field investigations during the site characterisation and site confirmation stages. The progress of this phase of site selection process will strongly depend on the response of local communities where potentially suitable areas will be identified, and on the successfulness and efficiency of the mediator conducting the negotiations with local communities. According to the most optimistic scenario the final site will be selected and confirmed by the period 2004 -2005.(author)

  2. A method to identify potential cold-climate vine growing sites

    DEFF Research Database (Denmark)

    Olsen, Jørgen L; Olesen, Asger; Breuning-Madsen, Henrik

    2011-01-01

    located on the basis of nation-wide climatic data on the sum of degree days and risk of frost. Within the most suitable areas a detailed survey of the amount of sunshine, topography, drainage and soil was carried out on the Røsnæs peninsula in north western Zealand, and eight well-suited vine growing...

  3. Data-Wave-Based Features Extraction and Its Application in Symbol Identifier Recognition and Positioning Suitable for Multi-Robot Systems

    Directory of Open Access Journals (Sweden)

    Xilong Liu

    2012-12-01

    Full Text Available In this paper, feature extraction based on data-wave is proposed. The concept of data-wave is introduced to describe the rising and falling trends of the data over the long-term which are detected based on ripple and wave filters. Supported by data-wave, a novel symbol identifier with significant structure features is designed and these features are extracted by constructing pixel chains. On this basis, the corresponding recognition and positioning approach is presented. The effectiveness of the proposed approach is verified by experiments.

  4. Provocative Endoscopy to Identify Bleeding Site in Upper Gastrointestinal Bleeding: A Novel Approach in Transarterial Embolization.

    Science.gov (United States)

    Kamo, Minobu; Fuwa, Sokun; Fukuda, Katsuyuki; Fujita, Yoshiyuki; Kurihara, Yasuyuki

    2016-07-01

    This report describes a novel approach to endoscopically induce bleeding by removing a clot from the bleeding site during angiography for upper gastrointestinal (UGI) hemorrhage. This procedure enabled accurate identification of the bleeding site, allowing for successful targeted embolization despite a negative initial angiogram. Provocative endoscopy may be a feasible and useful option for angiography of obscure bleeding sites in patients with UGI arterial hemorrhage. Copyright © 2016 SIR. Published by Elsevier Inc. All rights reserved.

  5. Identifying the most productive breeding sites for malaria mosquitoes in The Gambia

    NARCIS (Netherlands)

    Fillinger, U.; Sombroek, H.; Majambere, S.; Loon, van E.; Takken, W.; Lindsay, S.W.

    2009-01-01

    Background: Ideally larval control activities should be targeted at sites that generate the most adult vectors, thereby reducing operational costs. Despite the plethora of potential mosquito breeding sites found in the floodplains of the Gambia River, about 150 km from its mouth, during the rainy

  6. Investigations on site suitability for a final repository of low-and intermediate-level radioactive wastes. Status report of phase I investigations for the feasible Bois de la Glaive site (community of Ollon, VD)

    International Nuclear Information System (INIS)

    1988-10-01

    On 30 th September 1985, site suitability investigations with a view to disposal of low- and intermediate-level radioactive waste were licensed by the Federal Government at three locations - Bois de la Glaive (Canton Vaud), Oberbauenstock (Canton Uri) and Piz Pian Grand (Canton Graubuenden). This report presents the status of the investigations at Bois de la Glaive as at the end of 1987 and discusses the results of the programme. Because of the opposition of the community of Ollon, none of the investigations subject to authorization have been carried out, even though these investigations had been approved by the Federal Government on 30 th September 1985. Nevertheless, various investigations not requiring a license have provided a considerable store of data. The details of the work actually carried out are as follows: (1) Detailed geological mapping of the earth's surface over an area of 22.5 km 2 on a scale of 1:5000. This study included the first geological recording of the Galerie de Salin (Salin drift) which formed part of an 18 th -century mine. (2) The existing hydrogeological data on the area were compiled and provided a first impression of the overall hydrogeological conditions. (3) The provisional concept of a possible repository at Bois de la Glaive and of the corresponding exploration gallery was elaborated under the point of view of civil engineering and the long-term behaviour of the host rock was assessed qualitatively. To summarize, based on the present stage of the investigations and on rock- resp. site-specific knowledge of the anhydrite as a host rock, there are no real reasons for ruling out the site. 54 refs., 11 figs

  7. Application of Geophysical Techniques in Identifying UNE Signatures at Semipalatinsk Test Site (for OSI Purposes)

    Science.gov (United States)

    Belyashov, A.; Shaitorov, V.; Yefremov, M.

    2014-03-01

    This article describes geological and geophysical studies of an underground nuclear explosion area in one of the boreholes at the Semipalatinsk test site in Kazakhstan. During these studies, the typical elements of mechanical impact of the underground explosion on the host medium—fracturing of rock, spall zones, faults, cracks, etc., were observed. This information supplements to the database of underground nuclear explosion phenomenology and can be applied in fulfilling on-site inspection tasks under the Comprehensive Nuclear-Test-Ban Treaty.

  8. Identifying the Tunneling Site in Strong-Field Ionization of H_{2}^{+}.

    Science.gov (United States)

    Liu, Kunlong; Barth, Ingo

    2017-12-15

    The tunneling site of the electron in a molecule exposed to a strong laser field determines the initial position of the ionizing electron and, as a result, has a large impact on the subsequent ultrafast electron dynamics on the polyatomic Coulomb potential. Here, the tunneling site of the electron of H_{2}^{+} ionized by a strong circularly polarized (CP) laser pulse is studied by numerically solving the time-dependent Schrödinger equation. We show that the electron removed from the down-field site is directly driven away by the CP field and the lateral photoelectron momentum distribution (LPMD) exhibits a Gaussian-like distribution, whereas the corresponding LPMD of the electron removed from the up-field site differs from the Gaussian shape due to the Coulomb focusing and scattering by the down-field core. Our current study presents the direct evidence clarifying a long-standing controversy over the tunneling site in H_{2}^{+} and raises the important role of the tunneling site in strong-field molecular ionization.

  9. Refinement of a Method for Identifying Probable Archaeological Sites from Remotely Sensed Data

    Science.gov (United States)

    Tilton, James C.; Comer, Douglas C.; Priebe, Carey E.; Sussman, Daniel; Chen, Li

    2012-01-01

    To facilitate locating archaeological sites before they are compromised or destroyed, we are developing approaches for generating maps of probable archaeological sites, through detecting subtle anomalies in vegetative cover, soil chemistry, and soil moisture by analyzing remotely sensed data from multiple sources. We previously reported some success in this effort with a statistical analysis of slope, radar, and Ikonos data (including tasseled cap and NDVI transforms) with Student's t-test. We report here on new developments in our work, performing an analysis of 8-band multispectral Worldview-2 data. The Worldview-2 analysis begins by computing medians and median absolute deviations for the pixels in various annuli around each site of interest on the 28 band difference ratios. We then use principle components analysis followed by linear discriminant analysis to train a classifier which assigns a posterior probability that a location is an archaeological site. We tested the procedure using leave-one-out cross validation with a second leave-one-out step to choose parameters on a 9,859x23,000 subset of the WorldView-2 data over the western portion of Ft. Irwin, CA, USA. We used 100 known non-sites and trained one classifier for lithic sites (n=33) and one classifier for habitation sites (n=16). We then analyzed convex combinations of scores from the Archaeological Predictive Model (APM) and our scores. We found that that the combined scores had a higher area under the ROC curve than either individual method, indicating that including WorldView-2 data in analysis improved the predictive power of the provided APM.

  10. Biological data warehousing system for identifying transcriptional regulatory sites from gene expressions of microarray data.

    Science.gov (United States)

    Tsou, Ann-Ping; Sun, Yi-Ming; Liu, Chia-Lin; Huang, Hsien-Da; Horng, Jorng-Tzong; Tsai, Meng-Feng; Liu, Baw-Juine

    2006-07-01

    Identification of transcriptional regulatory sites plays an important role in the investigation of gene regulation. For this propose, we designed and implemented a data warehouse to integrate multiple heterogeneous biological data sources with data types such as text-file, XML, image, MySQL database model, and Oracle database model. The utility of the biological data warehouse in predicting transcriptional regulatory sites of coregulated genes was explored using a synexpression group derived from a microarray study. Both of the binding sites of known transcription factors and predicted over-represented (OR) oligonucleotides were demonstrated for the gene group. The potential biological roles of both known nucleotides and one OR nucleotide were demonstrated using bioassays. Therefore, the results from the wet-lab experiments reinforce the power and utility of the data warehouse as an approach to the genome-wide search for important transcription regulatory elements that are the key to many complex biological systems.

  11. Web-based Tool Identifies and Quantifies Potential Cost Savings Measures at the Hanford Site

    International Nuclear Information System (INIS)

    Renevitz, Marisa J.; Peschong, Jon C.; Charboneau, Briant L.; Simpson, Brett C.

    2014-01-01

    The Technical Improvement system is an approachable web-based tool that is available to Hanford DOE staff, site contractors, and general support service contractors as part of the baseline optimization effort underway at the Hanford Site. Finding and implementing technical improvements are a large part of DOE's cost savings efforts. The Technical Improvement dashboard is a key tool for brainstorming and monitoring the progress of submitted baseline optimization and potential cost/schedule efficiencies. The dashboard is accessible to users over the Hanford Local Area Network (HLAN) and provides a highly visual and straightforward status to management on the ideas provided, alleviating the need for resource intensive weekly and monthly reviews

  12. Superfund TIO videos. Set A. Identifying PRPS. Removal process: Removal site evaluation. Part 2. Audio-Visual

    International Nuclear Information System (INIS)

    1990-01-01

    The videotape is divided into three sections. Section 1 details the liability of Potentially Responsible Parties (PRPs) and describes the four classes of PRPs: current owners and operators, former owners and operators, generators, and transporters (if they selected the site). Section 2 lists the goals of the Potentially Responsible Party (PRP) search and explains how to identify key players during the PRP search. How to plan and conduct the PRP search is also outlined. Section 3 outlines the steps involved in conducting a removal site evaluation. A discussion of when to conduct a removal preliminary assessment, a removal site inspection, and an Engineering Evaluation/Cost Analysis (EE/AC) also is covered

  13. Identifying game elements suitable for MOOCs

    NARCIS (Netherlands)

    Antonaci, Alessandra; Klemke, Roland; Stracke, Christian M.; Specht, Marcus

    2017-01-01

    Massive Online Open Courses (MOOCs) have increasingly become objects of research interest and studies in recent years. While MOOCs could be a means to address massive audiences, they suffer from high drop-out rates and low user engagement. Gamification is known as the application of game

  14. FANCD2 binding identifies conserved fragile sites at large transcribed genes in avian cells

    DEFF Research Database (Denmark)

    Pentzold, Constanze; Shah, Shiraz Ali; Hansen, Niels Richard

    2018-01-01

    Common Chromosomal Fragile Sites (CFSs) are specific genomic regions prone to form breaks on metaphase chromosomes in response to replication stress. Moreover, CFSs are mutational hotspots in cancer genomes, showing that the mutational mechanisms that operate at CFSs are highly active in cancer c...

  15. Ligand-bound Structures and Site-directed Mutagenesis Identify the Acceptor and Secondary Binding Sites of Streptomyces coelicolor Maltosyltransferase GlgE*

    Science.gov (United States)

    Syson, Karl; Stevenson, Clare E. M.; Miah, Farzana; Barclay, J. Elaine; Tang, Minhong; Gorelik, Andrii; Rashid, Abdul M.; Lawson, David M.; Bornemann, Stephen

    2016-01-01

    GlgE is a maltosyltransferase involved in α-glucan biosynthesis in bacteria that has been genetically validated as a target for tuberculosis therapies. Crystals of the Mycobacterium tuberculosis enzyme diffract at low resolution so most structural studies have been with the very similar Streptomyces coelicolor GlgE isoform 1. Although the donor binding site for α-maltose 1-phosphate had been previously structurally defined, the acceptor site had not. Using mutagenesis, kinetics, and protein crystallography of the S. coelicolor enzyme, we have now identified the +1 to +6 subsites of the acceptor/product, which overlap with the known cyclodextrin binding site. The sugar residues in the acceptor subsites +1 to +5 are oriented such that they disfavor the binding of malto-oligosaccharides that bear branches at their 6-positions, consistent with the known acceptor chain specificity of GlgE. A secondary binding site remote from the catalytic center was identified that is distinct from one reported for the M. tuberculosis enzyme. This new site is capable of binding a branched α-glucan and is most likely involved in guiding acceptors toward the donor site because its disruption kinetically compromises the ability of GlgE to extend polymeric substrates. However, disruption of this site, which is conserved in the Streptomyces venezuelae GlgE enzyme, did not affect the growth of S. venezuelae or the structure of the polymeric product. The acceptor subsites +1 to +4 in the S. coelicolor enzyme are well conserved in the M. tuberculosis enzyme so their identification could help inform the design of inhibitors with therapeutic potential. PMID:27531751

  16. Neuropeptide Y binding sites in rat brain identified with purified neuropeptide Y-I125

    International Nuclear Information System (INIS)

    Walker, M.W.; Miller, R.J.

    1986-01-01

    Neuropeptide Y (NPY) is a widely distributed neuronally localized peptide with 36 amino acids, 5 of which are tyrosines. The authors wished to investigate the properties of specific receptors for NPY. They therefore labeled the tyrosines with I125 using chloramine T and then purified the peptide using HPLC. A single mono-iodinated species of NPY which yielded > 85% specific binding in rat forebrain synaptosomes was selected as the ligand for all subsequent experiments. A time course of binding showed that equilibrium conditions were reached in 60 minutes at 21 0 C. Scatchard plots revealed a single class of binding sites with a Kd and a Bmax of 3 x 10-10 M and 28 pmol/mg, respectively. Competition binding with unlabeled NPY showed 50% displacement of bound ligand at 1 x 10-10 M NPY. Competition binding with rat pancreatic polypeptide (RPP), a homologous peptide possessing little NPY-like activity, showed 50% displacement of bound ligand at 2 x 10 -7 M RPP. No binding was observed on F-11 or PC12 neuronal cell lines, or on HSWP fibroblast cells. They conclude that NPY-I125 purified to homogeneity with HPLC is a highly selective ligand for NPY receptor sites. They are currently investigating such sites in brain, gut, and other tissues

  17. Guide for Identifying and Converting High-Potential Petroleum Brownfield Sites to Alternative Fuel Stations

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, C.; Hettinger, D.; Mosey, G.

    2011-05-01

    Former gasoline stations that are now classified as brownfields can be good sites to sell alternative fuels because they are in locations that are convenient to vehicles and they may be seeking a new source of income. However, their success as alternative fueling stations is highly dependent on location-specific criteria. First, this report outlines what these criteria are, how to prioritize them, and then applies that assessment framework to five of the most popular alternative fuels--electricity, natural gas, hydrogen, ethanol, and biodiesel. The second part of this report delves into the criteria and tools used to assess an alternative fuel retail site at the local level. It does this through two case studies of converting former gasoline stations in the Seattle-Eugene area into electric charge stations. The third part of this report addresses steps to be taken after the specific site has been selected. This includes choosing and installing the recharging equipment, which includes steps to take in the permitting process and key players to include.

  18. Gradient temperature Raman spectroscopy identifies flexible sites in proline and alanine peptides

    Science.gov (United States)

    Continuous thermo dynamic Raman spectroscopy (TDRS) applies the temperature gradients utilized in differential scanning calorimetry (DSC) to Raman spectroscopy, providing a straightforward technique to identify molecular rearrangements that occur just prior to phase transitions. Herein we apply TDRS...

  19. COSMID: A Web-based Tool for Identifying and Validating CRISPR/Cas Off-target Sites

    Directory of Open Access Journals (Sweden)

    Thomas J Cradick

    2014-01-01

    Full Text Available Precise genome editing using engineered nucleases can significantly facilitate biological studies and disease treatment. In particular, clustered regularly interspaced short palindromic repeats (CRISPR with CRISPR-associated (Cas proteins are a potentially powerful tool for modifying a genome by targeted cleavage of DNA sequences complementary to designed guide strand RNAs. Although CRISPR/Cas systems can have on-target cleavage rates close to the transfection rates, they may also have relatively high off-target cleavage at similar genomic sites that contain one or more base pair mismatches, and insertions or deletions relative to the guide strand. We have developed a bioinformatics-based tool, COSMID (CRISPR Off-target Sites with Mismatches, Insertions, and Deletions that searches genomes for potential off-target sites (http://crispr.bme.gatech.edu. Based on the user-supplied guide strand and input parameters, COSMID identifies potential off-target sites with the specified number of mismatched bases and insertions or deletions when compared with the guide strand. For each site, amplification primers optimal for the chosen application are also given as output. This ranked-list of potential off-target sites assists the choice and evaluation of intended target sites, thus helping the design of CRISPR/Cas systems with minimal off-target effects, as well as the identification and quantification of CRISPR/Cas induced off-target cleavage in cells.

  20. A preliminary guidebook for identifying stratigraphic contacts at the Nevada Test Site

    International Nuclear Information System (INIS)

    Pawloski, G.A.; McKague, H.L.; Wagoner, J.L.; McKinnis, W.B.

    1992-01-01

    Lithologic variation, regional depositional trends, and the lack of written guidelines have resulted in inconsistencies in the recognition of stratigraphic contacts in drill holes at the Nevada Test Site (NTS). Stratigraphic identification, based on mineralogy of discrete samples, can be augmented by geophysical logs and downhole movies to more accurately and consistently locate contacts between units. Criteria are established for locating the base of the Pahute Mesa ash-flow tuff, the top of the Ammonia Tanks ash-flow tuff, the top of the Ammonia Tanks bedded tuff, and the top and the base of the Rainier Mesa Tuff

  1. On-site evaluation of the suitability of a wetted instream habitat in the Middle Rio Grande, New Mexico, for the Rio Grande silvery minnow (Hybognathus amarus)

    Science.gov (United States)

    2011-01-01

    Two in-situ exposure studies were conducted with the federally-listed endangered Rio Grande silvery minnow (Hybognathus amarus). One-year-old adults were exposed in cages deployed at three sites in the Middle Rio Grande, N. Mex., for 4 days to assess survival and for 26 days to evaluate survival, growth, overall health, and whole-body elemental composition. The test sites were located on the Pueblo of Isleta in the (1) main channel of the Middle Rio Grande, (2) 240-Wasteway irrigation return drain, and (3) wetted instream habitat created below the outfall of the 240-Wasteway irrigation return drain. During the cage exposures, temperature, dissolved oxygen, pH, conductivity, and turbidity were monitored continuously (15-minute intervals) and common constituents, nutrients, carbons, metals, and pesticides were measured at discrete intervals. In both studies, there were statistical differences in several water-quality parameters among sites; and except for turbidity, these differences were small and were not considered to be biologically significant. The cages used in the 4-day exposure study were ineffective at preventing access to the fish by predators, and survival was highly variable (20 percent to 90 percent) across sites. In the 26-day chronic exposure study, weight and condition factor of caged-exposed fish at all sites were significantly lower than those at test initiation. After 26 days of exposure, there were no significant differences in survival, total length, weight, or condition factor of fish across sites, but absolute weight loss and relative reduction in condition factor were significantly greater in fish at the wetted instream habitat site compared to those at the Middle Rio Grande site. There were no statistical differences in health assessment indices, mesenteric fat indices, or prevalence of abnormalities in cage-exposed fish among sites. Cage-exposed fish had higher health assessment indices and prevalence of fin anomalies and a lower mesenteric

  2. A Study Identifying Causes of Construction Waste Production and Applying Safety Management on Construction Site

    Directory of Open Access Journals (Sweden)

    Ali Asghar Najafpoor

    2014-09-01

    Full Text Available Background and purpose: In a recent century, the amount of construction waste has increased significantly. Although the building industry has a considerable role in the development of a society, it is regarded as an environmentally destructive. Source reduction is the highest goal in the waste management hierarchy and is in priority. It also has economic benefits by reducing costs associated with transportation, disposal or recycling of wastes. The present study is aimed to identify activities generating the wastes in design, transportation and storage and procurement of building materials. Materials and Methods: This was questionnaire survey. A total of 94 professionals in the construction industry were attended in this study. To determine the validity and reliability of the instrument, content validity method and Cronbach’s alpha coefficient (0.79 were used. Data were analyzed using SPSS for Windows. Frequencies, percentage, mean and standard deviation were determined in this research. Results: The results showed that handling and storage have been chosen as the most causative factor of waste production in construction activity. Improper material storage was identified major factor in producing waste in handling and storage phase. Usage of low-quality material in design stage and material price changes in procurement were recognized as major causes of waste production in these stages. Conclusion: All studied phases in this research were identified as causative factors in producing of waste. Identifying causes of construction waste production will help us decide better how to control this sort of wastes.

  3. Numeric E.I.A.`s techniques to determine suitable sites for solid waste sanitary plants; Tecniche numeriche di V.I.A. per l`individuazione dei siti idonei alla localizzazione di impianti di smaltimento dei rifiuti solidi

    Energy Technology Data Exchange (ETDEWEB)

    Valentini, A.

    1997-07-01

    A standard procedure for choosing suitable sites for the localization of waste treatment and disposal plants is the main step for a correct sanitary program. Two are the principal difficulties: to define a correct group of criteria, excluding and limiting conditions to be applied in the E.I.A.`s techniques: to employ a simplified and flexible methodology that permits to obtain a suitable sites hierarchy. An E.I.A.`s methodology is proposed, distinguished in three numeric techniques with different complexity. Beside, to limit the subjectiveness of the user`s judgement, two solutions are applied, i.e., a method to define the impact factors of the Plant system and a sensitivity test be applied on the importance range of values. =

  4. Identifying opportune landing sites in degraded visual environments with terrain and cultural databases

    Science.gov (United States)

    Moody, Marc; Fisher, Robert; Little, J. Kristin

    2014-06-01

    Boeing has developed a degraded visual environment navigational aid that is flying on the Boeing AH-6 light attack helicopter. The navigational aid is a two dimensional software digital map underlay generated by the Boeing™ Geospatial Embedded Mapping Software (GEMS) and fully integrated with the operational flight program. The page format on the aircraft's multi function displays (MFD) is termed the Approach page. The existing work utilizes Digital Terrain Elevation Data (DTED) and OpenGL ES 2.0 graphics capabilities to compute the pertinent graphics underlay entirely on the graphics processor unit (GPU) within the AH-6 mission computer. The next release will incorporate cultural databases containing Digital Vertical Obstructions (DVO) to warn the crew of towers, buildings, and power lines when choosing an opportune landing site. Future IRAD will include Light Detection and Ranging (LIDAR) point cloud generating sensors to provide 2D and 3D synthetic vision on the final approach to the landing zone. Collision detection with respect to terrain, cultural, and point cloud datasets may be used to further augment the crew warning system. The techniques for creating the digital map underlay leverage the GPU almost entirely, making this solution viable on most embedded mission computing systems with an OpenGL ES 2.0 capable GPU. This paper focuses on the AH-6 crew interface process for determining a landing zone and flying the aircraft to it.

  5. A bioinformatics approach for identifying transgene insertion sites using whole genome sequencing data.

    Science.gov (United States)

    Park, Doori; Park, Su-Hyun; Ban, Yong Wook; Kim, Youn Shic; Park, Kyoung-Cheul; Kim, Nam-Soo; Kim, Ju-Kon; Choi, Ik-Young

    2017-08-15

    Genetically modified crops (GM crops) have been developed to improve the agricultural traits of modern crop cultivars. Safety assessments of GM crops are of paramount importance in research at developmental stages and before releasing transgenic plants into the marketplace. Sequencing technology is developing rapidly, with higher output and labor efficiencies, and will eventually replace existing methods for the molecular characterization of genetically modified organisms. To detect the transgenic insertion locations in the three GM rice gnomes, Illumina sequencing reads are mapped and classified to the rice genome and plasmid sequence. The both mapped reads are classified to characterize the junction site between plant and transgene sequence by sequence alignment. Herein, we present a next generation sequencing (NGS)-based molecular characterization method, using transgenic rice plants SNU-Bt9-5, SNU-Bt9-30, and SNU-Bt9-109. Specifically, using bioinformatics tools, we detected the precise insertion locations and copy numbers of transfer DNA, genetic rearrangements, and the absence of backbone sequences, which were equivalent to results obtained from Southern blot analyses. NGS methods have been suggested as an effective means of characterizing and detecting transgenic insertion locations in genomes. Our results demonstrate the use of a combination of NGS technology and bioinformatics approaches that offers cost- and time-effective methods for assessing the safety of transgenic plants.

  6. YUCCA MOUNTAIN PROJECT RECOMMENDATION BY THE SECRETARY OF ENERGY REGARDING THE SUITABILITY OF THE YUCCA MOUNTAIN SITE FOR A REPOSITORY UNDER THE NUCLEAR WASTE POLICY ACT OF 1982

    Energy Technology Data Exchange (ETDEWEB)

    NA

    2002-03-26

    For more than half a century, since nuclear science helped us win World War II and ring in the Atomic Age, scientists have known that !he Nation would need a secure, permanent facility in which to dispose of radioactive wastes. Twenty years ago, when Congress adopted the Nuclear Waste Policy Act of 1982 (NWPA or ''the Act''), it recognized the overwhelming consensus in the scientific community that the best option for such a facility would be a deep underground repository. Fifteen years ago, Congress directed the Secretary of Energy to investigate and recommend to the President whether such a repository could be located safely at Yucca Mountain, Nevada. Since then, our country has spent billions of dollars and millions of hours of research endeavoring to answer this question. I have carefully reviewed the product of this study. In my judgment, it constitutes sound science and shows that a safe repository can be sited there. I also believe that compelling national interests counsel in favor of proceeding with this project. Accordingly, consistent with my responsibilities under the NWPA, today I am recommending that Yucca Mountain be developed as the site for an underground repository for spent fuel and other radioactive wastes. The first consideration in my decision was whether the Yucca Mountain site will safeguard the health and safety of the people, in Nevada and across the country, and will be effective in containing at minimum risk the material it is designed to hold. Substantial evidence shows that it will. Yucca Mountain is far and away the most thoroughly researched site of its kind in the world. It is a geologically stable site, in a closed groundwater basin, isolated on thousands of acres of Federal land, and farther from any metropolitan area than the great majority of less secure, temporary nuclear waste storage sites that exist in the country today. This point bears emphasis. We are not confronting a hypothetical problem. We have a

  7. YUCCA MOUNTAIN PROJECT RECOMMENDATION BY THE SECRETARY OF ENERGY REGARDING THE SUITABILITY OF THE YUCCA MOUNTAIN SITE FOR A REPOSITORY UNDER THE NUCLEAR WASTE POLICY ACT OF 1982

    International Nuclear Information System (INIS)

    2002-01-01

    For more than half a century, since nuclear science helped us win World War II and ring in the Atomic Age, scientists have known that the Nation would need a secure, permanent facility in which to dispose of radioactive wastes. Twenty years ago, when Congress adopted the Nuclear Waste Policy Act of 1982 (NWPA or ''the Act''), it recognized the overwhelming consensus in the scientific community that the best option for such a facility would be a deep underground repository. Fifteen years ago, Congress directed the Secretary of Energy to investigate and recommend to the President whether such a repository could be located safely at Yucca Mountain, Nevada. Since then, our country has spent billions of dollars and millions of hours of research endeavoring to answer this question. I have carefully reviewed the product of this study. In my judgment, it constitutes sound science and shows that a safe repository can be sited there. I also believe that compelling national interests counsel in favor of proceeding with this project. Accordingly, consistent with my responsibilities under the NWPA, today I am recommending that Yucca Mountain be developed as the site for an underground repository for spent fuel and other radioactive wastes. The first consideration in my decision was whether the Yucca Mountain site will safeguard the health and safety of the people, in Nevada and across the country, and will be effective in containing at minimum risk the material it is designed to hold. Substantial evidence shows that it will. Yucca Mountain is far and away the most thoroughly researched site of its kind in the world. It is a geologically stable site, in a closed groundwater basin, isolated on thousands of acres of Federal land, and farther from any metropolitan area than the great majority of less secure, temporary nuclear waste storage sites that exist in the country today. This point bears emphasis. We are not confronting a hypothetical problem. We have a staggering amount of

  8. Mesoscale Biotransformations of Uranium: Identifying Sites and Strategies where Reductive Immobilization is Practical

    International Nuclear Information System (INIS)

    Tetsu K. Tokunaga; Jiamin Wan; Terry C. Hazen; Mary K. Firestone; Eoin Brodie; Yongman Kim; Rebecca Daly

    2006-01-01

    Bioreduction of U in contaminated sediments is an attractive strategy because of its low cost, and because of short-term studies supporting its feasibility. However, any in-situ immobilization approach for U will require assurance of either permanent fixation, or of very low release rates into the biosphere. Our previous long-term (2 years) laboratory experiments have shown that organic carbon (OC) based U(VI) bioreduction to UO2 can be transient even under sustained reducing (methanogenic) conditions. The biogeochemical processes underlying this finding urgently need to be understood. The current research is designed to identify mechanisms responsible for anaerobic U oxidation, and identify conditions that will support long-term stability of bioreduced U. We are investigating: (1) effects of OC concentration and supply rate on remobilization of bioreduced U, (2) the roles of Fe- and Mn-oxides as potential U oxidants in sediments, and (3) the role of microorganisms in U reoxidation, and (4) influences of pH on U(IV)/U(VI) redox equilibrium

  9. Radioactive repository in Brazil - useful tools in suitable site selection; Repositorios radioativos no Brasil - ferramentas utilizadas na escolha de sitios adequados

    Energy Technology Data Exchange (ETDEWEB)

    Prates, Sonia P.; Javier Rios, Francisco; Alves, James V.; Fuzikawa, Kazuo [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN), Belo Horizonte, MG (Brazil)]. E-mail: pratess@cdtn.br

    2005-07-01

    Geological studies represent a useful tool in the selection of suitable areas for nuclear waste repository constructions. A detailed geological study can be obtained by structural - geological mapping, including tectonics studies; hydrogeological studies; petrological and geochemical studies of host rocks and geochemical studies of fluids in minerals. The study of the composition and behavior of fluids in minerals is based upon the study of solutions sometimes present inside the minerals, known as fluid inclusions. These solutions were imprisoned when minerals were formed and may represent the original conditions under which the minerals were formed. The working methodology allows to obtain these fluids presence and composition and to check their microfracturing and leaking probabilities. The LIFM ( Metallogenesis and Fluid Inclusions Laboratory) at CDTN is enable do develop some of these studies, mainly petrological and geochemical studies of host rocks and also geochemical studies of fluids in minerals. Some aspects of rocks used for nuclear waste repository constructions are discussed. (author)

  10. Identifying sites of replication initiation in yeast chromosomes: looking for origins in all the right places.

    Science.gov (United States)

    van Brabant, A J; Hunt, S Y; Fangman, W L; Brewer, B J

    1998-06-01

    DNA fragments that contain an active origin of replication generate bubble-shaped replication intermediates with diverging forks. We describe two methods that use two-dimensional (2-D) agarose gel electrophoresis along with DNA sequence information to identify replication origins in natural and artificial Saccharomyces cerevisiae chromosomes. The first method uses 2-D gels of overlapping DNA fragments to locate an active chromosomal replication origin within a region known to confer autonomous replication on a plasmid. A variant form of 2-D gels can be used to determine the direction of fork movement, and the second method uses this technique to find restriction fragments that are replicated by diverging forks, indicating that a bidirectional replication origin is located between the two fragments. Either of these two methods can be applied to the analysis of any genomic region for which there is DNA sequence information or an adequate restriction map.

  11. Rock suitability classification RSC 2012

    Energy Technology Data Exchange (ETDEWEB)

    McEwen, T. (ed.) [McEwen Consulting, Leicester (United Kingdom); Kapyaho, A. [Geological Survey of Finland, Espoo (Finland); Hella, P. [Saanio and Riekkola, Helsinki (Finland); Aro, S.; Kosunen, P.; Mattila, J.; Pere, T.

    2012-12-15

    This report presents Posiva's Rock Suitability Classification (RSC) system, developed for locating suitable rock volumes for repository design and construction. The RSC system comprises both the revised rock suitability criteria and the procedure for the suitability classification during the construction of the repository. The aim of the classification is to avoid such features of the host rock that may be detrimental to the favourable conditions within the repository, either initially or in the long term. This report also discusses the implications of applying the RSC system for the fulfilment of the regulatory requirements concerning the host rock as a natural barrier and the site's overall suitability for hosting a final repository of spent nuclear fuel.

  12. Rock suitability classification RSC 2012

    International Nuclear Information System (INIS)

    McEwen, T.; Kapyaho, A.; Hella, P.; Aro, S.; Kosunen, P.; Mattila, J.; Pere, T.

    2012-12-01

    This report presents Posiva's Rock Suitability Classification (RSC) system, developed for locating suitable rock volumes for repository design and construction. The RSC system comprises both the revised rock suitability criteria and the procedure for the suitability classification during the construction of the repository. The aim of the classification is to avoid such features of the host rock that may be detrimental to the favourable conditions within the repository, either initially or in the long term. This report also discusses the implications of applying the RSC system for the fulfilment of the regulatory requirements concerning the host rock as a natural barrier and the site's overall suitability for hosting a final repository of spent nuclear fuel

  13. Agroforestry suitability analysis based upon nutrient availability mapping: a GIS based suitability mapping

    Directory of Open Access Journals (Sweden)

    Firoz Ahmad

    2017-05-01

    Full Text Available Agroforestry has drawn the attention of researchers due to its capacity to reduce the poverty and land degradation, improve food security and mitigate the climate change. However, the progress in promoting agroforestry is held back due to the lack of reliable data sets and appropriate tools to accurately map and to have an adequate decision making system for agroforestry modules. Agroforestry suitability being one special form of land suitability is very pertinent to study in the current times when there is tremendous pressure on the land as it is a limited commodity. The study aims for applying the geo-spatial tools towards visualizing various soil and environmental data to reveal the trends and interrelationships and to achieve a nutrient availability and agroforestry suitability map. Using weight matrix and ranks, individual maps were developed in ArcGIS 10.1 platform to generate nutrient availability map, which was later used to develop agroforestry suitability map. Watersheds were delineated using DEM in some part of the study area and were evaluated for prioritizing it and agroforestry suitability of the watersheds were also done as per the schematic flowchart. Agroforestry suitability regions were delineated based upon the weight and ranks by integrated mapping. The total open area was identified 42.4% out of which 21.6% area was found to have high suitability towards agroforestry. Within the watersheds, 22 village points were generated for creating buffers, which were further evaluated showing its proximity to high suitable agroforestry sites thus generating tremendous opportunity to the villagers to carry out agroforestry projects locally. This research shows the capability of remote sensing in studying agroforestry practices and in estimating the prominent factors for its optimal productivity. The ongoing agroforestry projects can be potentially diverted in the areas of high suitability as an extension. The use of ancillary data in GIS

  14. Small molecule inhibitors of the LEDGF site of human immunodeficiency virus integrase identified by fragment screening and structure based design.

    Directory of Open Access Journals (Sweden)

    Thomas S Peat

    Full Text Available A fragment-based screen against human immunodeficiency virus type 1 (HIV integrase led to a number of compounds that bound to the lens epithelium derived growth factor (LEDGF binding site of the integrase catalytic core domain. We determined the crystallographic structures of complexes of the HIV integrase catalytic core domain for 10 of these compounds and quantitated the binding by surface plasmon resonance. We demonstrate that the compounds inhibit the interaction of LEDGF with HIV integrase in a proximity AlphaScreen assay, an assay for the LEDGF enhancement of HIV integrase strand transfer and in a cell based assay. The compounds identified represent a potential framework for the development of a new series of HIV integrase inhibitors that do not bind to the catalytic site of the enzyme.

  15. Using the Textpresso Site-Specific Recombinases Web server to identify Cre expressing mouse strains and floxed alleles.

    Science.gov (United States)

    Condie, Brian G; Urbanski, William M

    2014-01-01

    Effective tools for searching the biomedical literature are essential for identifying reagents or mouse strains as well as for effective experimental design and informed interpretation of experimental results. We have built the Textpresso Site Specific Recombinases (Textpresso SSR) Web server to enable researchers who use mice to perform in-depth searches of a rapidly growing and complex part of the mouse literature. Our Textpresso Web server provides an interface for searching the full text of most of the peer-reviewed publications that report the characterization or use of mouse strains that express Cre or Flp recombinase. The database also contains most of the publications that describe the characterization or analysis of strains carrying conditional alleles or transgenes that can be inactivated or activated by site-specific recombinases such as Cre or Flp. Textpresso SSR complements the existing online databases that catalog Cre and Flp expression patterns by providing a unique online interface for the in-depth text mining of the site specific recombinase literature.

  16. Using transcranial magnetic stimulation of the undamaged brain to identify lesion sites that predict language outcome after stroke.

    Science.gov (United States)

    Lorca-Puls, Diego L; Gajardo-Vidal, Andrea; Seghier, Mohamed L; Leff, Alexander P; Sethi, Varun; Prejawa, Susan; Hope, Thomas M H; Devlin, Joseph T; Price, Cathy J

    2017-06-01

    Transcranial magnetic stimulation focused on either the left anterior supramarginal gyrus or opercular part of the left inferior frontal gyrus has been reported to transiently impair the ability to perform phonological more than semantic tasks. Here we tested whether phonological processing abilities were also impaired following lesions to these regions in right-handed, English speaking adults, who were investigated at least 1 year after a left-hemisphere stroke. When our regions of interest were limited to 0.5 cm3 of grey matter centred around sites that had been identified with transcranial magnetic stimulation-based functional localization, phonological impairments were observed in 74% (40/54) of patients with damage to the regions and 21% (21/100) of patients sparing these regions. This classification accuracy was better than that observed when using regions of interest centred on activation sites in previous functional magnetic resonance imaging studies of phonological processing, or transcranial magnetic stimulation sites that did not use functional localization. New regions of interest were generated by redefining the borders of each of the transcranial magnetic stimulation sites to include areas that were consistently damaged in the patients with phonological impairments. This increased the incidence of phonological impairments in the presence of damage to 85% (46/54) and also reduced the incidence of phonological impairments in the absence of damage to 15% (15/100). The difference in phonological processing abilities between those with and without damage to these 'transcranial magnetic stimulation-guided' regions remained highly significant even after controlling for the effect of lesion size. The classification accuracy of the transcranial magnetic stimulation-guided regions was validated in a second sample of 108 patients and found to be better than that for (i) functional magnetic resonance imaging-guided regions; (ii) a region identified from an

  17. A Prospective Comparison of 18F-FDG PET/CT and CT as Diagnostic Tools to Identify the Primary Tumor Site in Patients with Extracervical Carcinoma of Unknown Primary Site

    DEFF Research Database (Denmark)

    Moller, Anne Kirstine H; Loft, Annika; Berthelsen, Anne K

    2012-01-01

    that the same set of criteria were used for classification of patients, that is, either as CUP patients or patients with a suggested primary tumor site. The independently obtained suggestions of primary tumor sites using PET/CT and CT were correlated with the SR to reach a consensus regarding true-positive (TP......), true-negative, false-negative, and false-positive results.Results. SR identified a primary tumor site in 66 CUP patients (48.9%). PET/CT identified 38 TP primary tumor sites and CT identified 43 TP primary tumor sites. No statistically significant differences were observed between (18)F-FDG PET...

  18. Identifying strategic sites for Green-Infrastructures (GI) to manage stormwater in a miscellaneous use urban African watershed

    Science.gov (United States)

    Selker, J. S.; Kahsai, S. K.

    2017-12-01

    Green Infrastructure (GI) or Low impact development (LID), is a land use planning and design approach with the objective of mitigating land development impacts to the environment, and is ever more looked to as a way to lessen runoff and pollutant loading to receiving water bodies. Broad-scale approaches for siting GI/LID have been developed for agricultural watersheds, but are rare for urban watersheds, largely due to greater land use complexity. And it is even more challenging when it comes to Urban Africa due to the combination of poor data quality, rapid and unplanned development, and civic institutions unable to reliably carry out regular maintenance. We present a spacio-temporal simulation-based approach to identify an optimal prioritization of sites for GI/LID based on DEM, land use and land cover. Optimization used is a multi-objective optimization tool along with an urban storm water management model (SWMM) to identify the most cost-effective combination of LID/GI. This was applied to an urban watershed in NW Kampala, Lubigi Catchment (notorious for being heavily flooded every year), with a miscellaneous use watershed in Uganda, as a case-study to demonstrate the approach.

  19. Genome-wide screens for in vivo Tinman binding sites identify cardiac enhancers with diverse functional architectures.

    Directory of Open Access Journals (Sweden)

    Hong Jin

    Full Text Available The NK homeodomain factor Tinman is a crucial regulator of early mesoderm patterning and, together with the GATA factor Pannier and the Dorsocross T-box factors, serves as one of the key cardiogenic factors during specification and differentiation of heart cells. Although the basic framework of regulatory interactions driving heart development has been worked out, only about a dozen genes involved in heart development have been designated as direct Tinman target genes to date, and detailed information about the functional architectures of their cardiac enhancers is lacking. We have used immunoprecipitation of chromatin (ChIP from embryos at two different stages of early cardiogenesis to obtain a global overview of the sequences bound by Tinman in vivo and their linked genes. Our data from the analysis of ~50 sequences with high Tinman occupancy show that the majority of such sequences act as enhancers in various mesodermal tissues in which Tinman is active. All of the dorsal mesodermal and cardiac enhancers, but not some of the others, require tinman function. The cardiac enhancers feature diverse arrangements of binding motifs for Tinman, Pannier, and Dorsocross. By employing these cardiac and non-cardiac enhancers in machine learning approaches, we identify a novel motif, termed CEE, as a classifier for cardiac enhancers. In vivo assays for the requirement of the binding motifs of Tinman, Pannier, and Dorsocross, as well as the CEE motifs in a set of cardiac enhancers, show that the Tinman sites are essential in all but one of the tested enhancers; although on occasion they can be functionally redundant with Dorsocross sites. The enhancers differ widely with respect to their requirement for Pannier, Dorsocross, and CEE sites, which we ascribe to their different position in the regulatory circuitry, their distinct temporal and spatial activities during cardiogenesis, and functional redundancies among different factor binding sites.

  20. Selection of Inhibitor-Resistant Viral Potassium Channels Identifies a Selectivity Filter Site that Affects Barium and Amantadine Block

    Science.gov (United States)

    Fujiwara, Yuichiro; Arrigoni, Cristina; Domigan, Courtney; Ferrara, Giuseppina; Pantoja, Carlos; Thiel, Gerhard; Moroni, Anna; Minor, Daniel L.

    2009-01-01

    Background Understanding the interactions between ion channels and blockers remains an important goal that has implications for delineating the basic mechanisms of ion channel function and for the discovery and development of ion channel directed drugs. Methodology/Principal Findings We used genetic selection methods to probe the interaction of two ion channel blockers, barium and amantadine, with the miniature viral potassium channel Kcv. Selection for Kcv mutants that were resistant to either blocker identified a mutant bearing multiple changes that was resistant to both. Implementation of a PCR shuffling and backcrossing procedure uncovered that the blocker resistance could be attributed to a single change, T63S, at a position that is likely to form the binding site for the inner ion in the selectivity filter (site 4). A combination of electrophysiological and biochemical assays revealed a distinct difference in the ability of the mutant channel to interact with the blockers. Studies of the analogous mutation in the mammalian inward rectifier Kir2.1 show that the T→S mutation affects barium block as well as the stability of the conductive state. Comparison of the effects of similar barium resistant mutations in Kcv and Kir2.1 shows that neighboring amino acids in the Kcv selectivity filter affect blocker binding. Conclusions/Significance The data support the idea that permeant ions have an integral role in stabilizing potassium channel structure, suggest that both barium and amantadine act at a similar site, and demonstrate how genetic selections can be used to map blocker binding sites and reveal mechanistic features. PMID:19834614

  1. Use of geographic information systems (GIS to identify adequate sites for cultivation of the seaweed Gracilaria birdiae in Rio Grande do Norte, Northeastern Brazil

    Directory of Open Access Journals (Sweden)

    Flavo E. S. de Sousa

    2012-06-01

    Full Text Available This study was designed to select potential areas for cultivation of the seaweed Gracilaria birdiae Plastino & E.C. Oliveira (Gracilariales, Rhodophyta on the coast of Rio Grande do Norte state, Brazil. The Geographic Information System (GIS and multi-criteria evaluation (MCE were used to identify the most suitable areas. The Analytical Hierarchical Process (AHP was applied to establish MCE weights, thereby generating viable areas for species cultivation. From a total of 3316.82 ha, around 53.67% (1780.06 ha were indicated as highly suitable areas, 40.93% (1357.58 ha as moderately suitable and 5.40% (179.18 ha as scarcely suitable for seaweed cultivation. Seven areas (1084.62 ha are located on the northern coast and 20 (2232.20 ha on the eastern coast. The results show that GIS can be used as an effective instrument for selecting seaweed cultivation areas.

  2. SUITABILITY OF DAM SITES IN MAURITIUS

    African Journals Online (AJOL)

    cistvr

    GENERAL GEOLOGY AND HYDROGEOLOGY OF MAURITIUS .... The results of these investigations were checked and completed by a drilling and ..... obtained while discussing with the gauge reader for the water level in the reservoir.

  3. SITE SUITABILITY ANALYSIS AND ROUTE OPTIMIZATION FOR ...

    African Journals Online (AJOL)

    Fimba

    University of Technology, Minna, Niger State, Nigeria .... Garmin Hand held Global positioning system and the software used was ESRI's ArcMap 10.1. The Table 1 .... Innovative Paradigms in Engineering & Technology (NCIPET-2012). ... Disposal in Jimeta, Nigeria, Adamawa state university Journal of scientific research.

  4. An evaluation of applicability of seismic refraction method in identifying shallow archaeological features A case study at archaeological site

    Science.gov (United States)

    Jahangardi, Morteza; Hafezi Moghaddas, Naser; Keivan Hosseini, Sayyed; Garazhian, Omran

    2015-04-01

    We applied the seismic refraction method at archaeological site, Tepe Damghani located in Sabzevar, NE of Iran, in order to determine the structures of archaeological interests. This pre-historical site has special conditions with respect to geographical location and geomorphological setting, so it is an urban archaeological site, and in recent years it has been used as an agricultural field. In spring and summer of 2012, the third season of archaeological excavation was carried out. Test trenches of excavations in this site revealed that cultural layers were often disturbed adversely due to human activities such as farming and road construction in recent years. Conditions of archaeological cultural layers in southern and eastern parts of Tepe are slightly better, for instance, in test trench 3×3 m²1S03, third test trench excavated in the southern part of Tepe, an adobe in situ architectural structure was discovered that likely belongs to cultural features of a complex with 5 graves. After conclusion of the third season of archaeological excavation, all of the test trenches were filled with the same soil of excavated test trenches. Seismic refraction method was applied with12 channels of P geophones in three lines with a geophone interval of 0.5 meter and a 1.5 meter distance between profiles on test trench 1S03. The goal of this operation was evaluation of applicability of seismic method in identification of archaeological features, especially adobe wall structures. Processing of seismic data was done with the seismic software, SiesImager. Results were presented in the form of seismic section for every profile, so that identification of adobe wall structures was achieved hardly. This could be due to that adobe wall had been built with the same materials of the natural surrounding earth. Thus, there is a low contrast and it has an inappropriate effect on seismic processing and identifying of archaeological features. Hence the result could be that application of

  5. TSSer: an automated method to identify transcription start sites in prokaryotic genomes from differential RNA sequencing data.

    Science.gov (United States)

    Jorjani, Hadi; Zavolan, Mihaela

    2014-04-01

    Accurate identification of transcription start sites (TSSs) is an essential step in the analysis of transcription regulatory networks. In higher eukaryotes, the capped analysis of gene expression technology enabled comprehensive annotation of TSSs in genomes such as those of mice and humans. In bacteria, an equivalent approach, termed differential RNA sequencing (dRNA-seq), has recently been proposed, but the application of this approach to a large number of genomes is hindered by the paucity of computational analysis methods. With few exceptions, when the method has been used, annotation of TSSs has been largely done manually. In this work, we present a computational method called 'TSSer' that enables the automatic inference of TSSs from dRNA-seq data. The method rests on a probabilistic framework for identifying both genomic positions that are preferentially enriched in the dRNA-seq data as well as preferentially captured relative to neighboring genomic regions. Evaluating our approach for TSS calling on several publicly available datasets, we find that TSSer achieves high consistency with the curated lists of annotated TSSs, but identifies many additional TSSs. Therefore, TSSer can accelerate genome-wide identification of TSSs in bacterial genomes and can aid in further characterization of bacterial transcription regulatory networks. TSSer is freely available under GPL license at http://www.clipz.unibas.ch/TSSer/index.php

  6. SVM-based prediction of propeptide cleavage sites in spider toxins identifies toxin innovation in an Australian tarantula.

    Directory of Open Access Journals (Sweden)

    Emily S W Wong

    Full Text Available Spider neurotoxins are commonly used as pharmacological tools and are a popular source of novel compounds with therapeutic and agrochemical potential. Since venom peptides are inherently toxic, the host spider must employ strategies to avoid adverse effects prior to venom use. It is partly for this reason that most spider toxins encode a protective proregion that upon enzymatic cleavage is excised from the mature peptide. In order to identify the mature toxin sequence directly from toxin transcripts, without resorting to protein sequencing, the propeptide cleavage site in the toxin precursor must be predicted bioinformatically. We evaluated different machine learning strategies (support vector machines, hidden Markov model and decision tree and developed an algorithm (SpiderP for prediction of propeptide cleavage sites in spider toxins. Our strategy uses a support vector machine (SVM framework that combines both local and global sequence information. Our method is superior or comparable to current tools for prediction of propeptide sequences in spider toxins. Evaluation of the SVM method on an independent test set of known toxin sequences yielded 96% sensitivity and 100% specificity. Furthermore, we sequenced five novel peptides (not used to train the final predictor from the venom of the Australian tarantula Selenotypus plumipes to test the accuracy of the predictor and found 80% sensitivity and 99.6% 8-mer specificity. Finally, we used the predictor together with homology information to predict and characterize seven groups of novel toxins from the deeply sequenced venom gland transcriptome of S. plumipes, which revealed structural complexity and innovations in the evolution of the toxins. The precursor prediction tool (SpiderP is freely available on ArachnoServer (http://www.arachnoserver.org/spiderP.html, a web portal to a comprehensive relational database of spider toxins. All training data, test data, and scripts used are available from

  7. Identifying and Further Understanding the Role of Bacteria and Archaea in a Basic Mine Drainage Remediation Site in Tanoma, PA

    Science.gov (United States)

    Sharp, G.; Mount, G.

    2017-12-01

    Acid mine drainage pollutes over 3000 miles of streams and ground water in Pennsylvania alone, and in response many solutions have been developed to counteract the effects of acidic mine drainage. It is estimated by USGS that restoring these watersheds would cost 5 billion-15 billion in total. As economic conditions place limits on expenditures, cost effective means of remediation will be of critical importance. One such method is passive bioremediation, and in the case of metal contamination, self-sustaining oxygenation. Our location of interest is the Tanoma Acid Mine Drainage engineered wetland near Tanoma, Pennsylvania. It is estimated that up to 5,000 gallons per minute is currently being discharged into the site. While most local remediation sites are acidic (pH bioremediation in more neutral pH setting (pH of 5.5-7.5). In this study, we look to further understand biologic, chemical, and hydrologic controls that contribute to the efficiency of the wetland. Our research will focus on the spatial and temporal distribution of biomass through the wetland system as well as changes in water and soil chemistry. Local biofilm (Leptothrix discophora ) are an important part of the remediation process, using iron from the water as an energy source. The bacteria reduce the iron content of the water, precipitating it onto the pond bed as Terraced Iron Formations (TIF). Terraces iron formations (TIF's) are correlated with localized biofilm-archaea densities where archaea thrive in iron rich sediments. By determining bacteria densities in the wetland through gram stain analysis, we can further understand their role in terraced iron formation creation, find localized TIF's that occur, and correlate methane production due to archaea in that location. Mapping TIF locations and identifying bacteria densities will help determine the bioremediation effects on the overall efficiency of iron reduction throughout the Tanoma AMD passive remediation system.

  8. Isthmus sites identified by Ripple Mapping are usually anatomically stable: A novel method to guide atrial substrate ablation?

    Science.gov (United States)

    Luther, Vishal; Qureshi, Norman; Lim, Phang Boon; Koa-Wing, Michael; Jamil-Copley, Shahnaz; Ng, Fu Siong; Whinnett, Zachary; Davies, D Wyn; Peters, Nicholas S; Kanagaratnam, Prapa; Linton, Nick

    2018-03-01

    Postablation reentrant ATs depend upon conducting isthmuses bordered by scar. Bipolar voltage maps highlight scar as sites of low voltage, but the voltage amplitude of an electrogram depends upon the myocardial activation sequence. Furthermore, a voltage threshold that defines atrial scar is unknown. We used Ripple Mapping (RM) to test whether these isthmuses were anatomically fixed between different activation vectors and atrial rates. We studied post-AF ablation ATs where >1 rhythm was mapped. Multipolar catheters were used with CARTO Confidense for high-density mapping. RM visualized the pattern of activation, and the voltage threshold below which no activation was seen. Isthmuses were characterized at this threshold between maps for each patient. Ten patients were studied (Map 1 was AT1; Map 2: sinus 1/10, LA paced 2/10, AT2 with reverse CS activation 3/10; AT2 CL difference 50 ± 30 ms). Point density was similar between maps (Map 1: 2,589 ± 1,330; Map 2: 2,214 ± 1,384; P  =  0.31). RM activation threshold was 0.16 ± 0.08 mV. Thirty-one isthmuses were identified in Map 1 (median 3 per map; width 27 ± 15 mm; 7 anterior; 6 roof; 8 mitral; 9 septal; 1 posterior). Importantly, 7 of 31 (23%) isthmuses were unexpectedly identified within regions without prior ablation. AT1 was treated following ablation of 11/31 (35%) isthmuses. Of the remaining 20 isthmuses, 14 of 16 isthmuses (88%) were consistent between the two maps (four were inadequately mapped). Wavefront collision caused variation in low voltage distribution in 2 of 16 (12%). The distribution of isthmuses and nonconducting tissue within the ablated left atrium, as defined by RM, appear concordant between rhythms. This could guide a substrate ablative approach. © 2018 Wiley Periodicals, Inc.

  9. Novel colchicine-site binders with a cyclohexanedione scaffold identified through a ligand-based virtual screening approach.

    Science.gov (United States)

    Canela, María-Dolores; Pérez-Pérez, María-Jesús; Noppen, Sam; Sáez-Calvo, Gonzalo; Díaz, J Fernando; Camarasa, María-José; Liekens, Sandra; Priego, Eva-María

    2014-05-22

    Vascular disrupting agents (VDAs) constitute an innovative anticancer therapy that targets the tumor endothelium, leading to tumor necrosis. Our approach for the identification of new VDAs has relied on a ligand 3-D shape similarity virtual screening (VS) approach using the ROCS program as the VS tool and as query colchicine and TN-16, which both bind the α,β-tubulin dimer. One of the hits identified, using TN-16 as query, has been explored by the synthesis of its structural analogues, leading to 2-(1-((2-methoxyphenyl)amino)ethylidene)-5-phenylcyclohexane-1,3-dione (compound 16c) with an IC50 = 0.09 ± 0.01 μM in HMEC-1 and BAEC, being 100-fold more potent than the initial hit. Compound 16c caused cell cycle arrest in the G2/M phase and interacted with the colchicine-binding site in tubulin, as confirmed by a competition assay with N,N'-ethylenebis(iodoacetamide) and by fluorescence spectroscopy. Moreover, 16c destroyed an established endothelial tubular network at 1 μM and inhibited the migration and invasion of human breast carcinoma cells at 0.4 μM. In conclusion, our approach has led to a new chemotype of promising antiproliferative compounds with antimitotic and potential VDA properties.

  10. Simulations of hydrogen sorption in rht-MOF-1: identifying the binding sites through explicit polarization and quantum rotation calculations

    KAUST Repository

    Pham, Tony

    2014-01-01

    Grand canonical Monte Carlo (GCMC) simulations of hydrogen sorption were performed in rht-MOF-1, a metal-organic framework (MOF) that consists of isophthalate groups joined by copper paddlewheel clusters and Cu3O trimers through tetrazolate moeities. This is a charged rht-MOF that contains extra-framework nitrate counterions within the material. For the simulations performed herein, excellent agreement with experiment was achieved for the simulated hydrogen sorption isotherms and calculated isosteric heat of adsorption, Qst, values only when using a polarizable potential. Thermodynamic agreement is demonstrated via comparing to experimental isotherms and binding sites are revealed by combining simulation and inelastic neutron scattering (INS) data. Simulations involving explicit many-body polarization interactions assisted in the determination of the binding sites in rht-MOF-1 through the distribution of the induced dipoles that led to strong adsorbate interactions. Four distinct hydrogen sorption sites were determined from the polarization distribution: the nitrate ions located in the corners of the truncated tetrahedral cages, the Cu2+ ions of the paddlewheels that project into the truncated tetrahedral and truncated octahedral cages (Cu1 ions), the Cu2+ ions of the Cu3O trimers (Cu3 ions), and the sides of the paddlewheels in the cuboctahedral cage. The simulations revealed that the initial sorption sites for hydrogen in rht-MOF-1 are the nitrate ions; this site corresponds to the high initial Qst value for hydrogen (9.5 kJ mol-1) in the MOF. The radial distribution functions, g(r), about the Cu2+ ions at various loadings revealed that the Cu1 ions are the preferred open-metal sorption sites for hydrogen at low loading, while the Cu3 ions become occupied at higher loadings. The validation of the aforementioned sorption sites in rht-MOF-1 was confirmed by calculating the two-dimensional quantum rotational levels about each site and comparing the levels to the

  11. RED: A Java-MySQL Software for Identifying and Visualizing RNA Editing Sites Using Rule-Based and Statistical Filters.

    Directory of Open Access Journals (Sweden)

    Yongmei Sun

    Full Text Available RNA editing is one of the post- or co-transcriptional processes that can lead to amino acid substitutions in protein sequences, alternative pre-mRNA splicing, and changes in gene expression levels. Although several methods have been suggested to identify RNA editing sites, there remains challenges to be addressed in distinguishing true RNA editing sites from its counterparts on genome and technical artifacts. In addition, there lacks a software framework to identify and visualize potential RNA editing sites. Here, we presented a software - 'RED' (RNA Editing sites Detector - for the identification of RNA editing sites by integrating multiple rule-based and statistical filters. The potential RNA editing sites can be visualized at the genome and the site levels by graphical user interface (GUI. To improve performance, we used MySQL database management system (DBMS for high-throughput data storage and query. We demonstrated the validity and utility of RED by identifying the presence and absence of C→U RNA-editing sites experimentally validated, in comparison with REDItools, a command line tool to perform high-throughput investigation of RNA editing. In an analysis of a sample data-set with 28 experimentally validated C→U RNA editing sites, RED had sensitivity and specificity of 0.64 and 0.5. In comparison, REDItools had a better sensitivity (0.75 but similar specificity (0.5. RED is an easy-to-use, platform-independent Java-based software, and can be applied to RNA-seq data without or with DNA sequencing data. The package is freely available under the GPLv3 license at http://github.com/REDetector/RED or https://sourceforge.net/projects/redetector.

  12. RED: A Java-MySQL Software for Identifying and Visualizing RNA Editing Sites Using Rule-Based and Statistical Filters.

    Science.gov (United States)

    Sun, Yongmei; Li, Xing; Wu, Di; Pan, Qi; Ji, Yuefeng; Ren, Hong; Ding, Keyue

    2016-01-01

    RNA editing is one of the post- or co-transcriptional processes that can lead to amino acid substitutions in protein sequences, alternative pre-mRNA splicing, and changes in gene expression levels. Although several methods have been suggested to identify RNA editing sites, there remains challenges to be addressed in distinguishing true RNA editing sites from its counterparts on genome and technical artifacts. In addition, there lacks a software framework to identify and visualize potential RNA editing sites. Here, we presented a software - 'RED' (RNA Editing sites Detector) - for the identification of RNA editing sites by integrating multiple rule-based and statistical filters. The potential RNA editing sites can be visualized at the genome and the site levels by graphical user interface (GUI). To improve performance, we used MySQL database management system (DBMS) for high-throughput data storage and query. We demonstrated the validity and utility of RED by identifying the presence and absence of C→U RNA-editing sites experimentally validated, in comparison with REDItools, a command line tool to perform high-throughput investigation of RNA editing. In an analysis of a sample data-set with 28 experimentally validated C→U RNA editing sites, RED had sensitivity and specificity of 0.64 and 0.5. In comparison, REDItools had a better sensitivity (0.75) but similar specificity (0.5). RED is an easy-to-use, platform-independent Java-based software, and can be applied to RNA-seq data without or with DNA sequencing data. The package is freely available under the GPLv3 license at http://github.com/REDetector/RED or https://sourceforge.net/projects/redetector.

  13. Towards identifying the active sites on RuO2(110) in catalyzing oxygen evolution  

    DEFF Research Database (Denmark)

    Rao, Reshma R.; Kolb, Manuel J.; Halck, Niels Bendtsen

    2017-01-01

    While the surface atomic structure of RuO2 has been well studied in ultra high vacuum, much less is known about the interaction between water and RuO2 in aqueous solution. In this work, in situ surface X-ray scattering measurements combined with density functional theory (DFT) were used to determ......While the surface atomic structure of RuO2 has been well studied in ultra high vacuum, much less is known about the interaction between water and RuO2 in aqueous solution. In this work, in situ surface X-ray scattering measurements combined with density functional theory (DFT) were used...... on the coordinatively unsaturated Ru sites (CUS) and hydrogen adsorbed to the bridging oxygen sites. At potentials relevant to the oxygen evolution reaction (OER), an –OO species on the Ru CUS sites was detected, which was stabilized by a neighboring –OH group on the Ru CUS or bridge site. Combining potential...

  14. Pairwise comparisons of ten porcine tissues identify differential transcriptional regulation at the gene, isoform, promoter and transcription start site level

    DEFF Research Database (Denmark)

    Farajzadeh, Leila; Hornshøj, Henrik; Momeni, Jamal

    2013-01-01

    , isoform, and transcription start site (TSS), and promoter level showed that several of the genes differed at all four levels. Interestingly, these genes were mainly annotated to the "electron transport chain" and neuronal differentiation, emphasizing that "tissue important" genes are regulated at several...

  15. Suitable footwear for enhanced safety

    CERN Document Server

    2004-01-01

    Safety shoes are the theme of a new safety campaign. Always remember that accidents can happen - even to your feet! When entering hazardous areas such as underground halls, work sites, experiment assembly sites, workshops etc., sandals, ordinary shoes or similar light footwear should not be worn. Whatever the risks to which you may be exposed, always think safety and wear suitable footwear, i.e. safety shoes, which have non-slip soles and steel reinforcements to protect your feet from being crushed, fractured or pierced. Is it serious, Doctor? "Some traumas resulting from foot-related accidents - open fractures for instance - can be quite serious," explains CERN Works Doctor Véronique Fassnacht. "But the most common injuries are sprained ankles sustained during simple falls caused by differences in floor-levels (e.g. false floors). Fractures, bruising, surface wounds or deep wounds caused by objects falling onto the top of the foot are also quite common." ...

  16. Environmental assessment: Davis Canyon site, Utah

    Energy Technology Data Exchange (ETDEWEB)

    none,

    1986-05-01

    In February 1983, the US Department of Energy (DOE) identified the Davis Canyon site in Utah as one of the nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high- level radioactive waste. To determine their suitability, the Davis Canyon site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. These evaluations were reported in draft environmental assessments (EAs), which were issued for public review and comment. After considering the comments received on the draft EAs, the DOE prepared the final EA. The Davis Canyon site is in the Paradox Basin, which is one of five distinct geohydrologic settings considered for the first repository. This setting contains one other potentially acceptable site -- the Lavender Canyon site. Although the Lavender Canyon site is suitable for site characterization, the DOE has concluded that the Davis Canyon site is the preferred site in the Paradox Basin. On the basis of the evaluations reported in this EA, the DOE has found that the Davis Canyon site is not disqualified under the guidelines. Furthermore, the DOE has found that the site is suitable for site characterization because the evidence does not support a conclusion that the site will not be able to meet each of the qualifying conditions specified in the guidelines. On the basis of these findings, the DOE is nominating the Davis Canyon site as one of the five sites suitable for characterization.

  17. Environmental assessment: Davis Canyon site, Utah

    Energy Technology Data Exchange (ETDEWEB)

    none,

    1986-05-01

    In February 1983, the US Department of Energy (DOE) identified the Davis Canyon site in Utah as one of the nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Davis Canyon site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. These evaluations were reported in draft environmental assessments (EAs), which were issued for public review and comment. After considering the comments received on the draft EAs, the DOE prepared the final EA. The Davis Canyon site is in the Paradox Basin, which is one of five distinct geohydrologic settings considering for the first repository. This setting contains one other potentially acceptable site -- the Lavender Canyon site. Although the Lavender Canyon site is suitable for site characterization, the DOE has concluded that the Davis Canyon site is the preferred site in the Paradox Basin. On the basis of the evaluations reported in this EA, the DOE has found that the Davis Canyon site is not disqualified under the guidelines. Furthermore, the DOE has found that the site is suitable for site characterization because the evidence does not support a conclusion that the site will not be able to meet each of the qualifying conditions specified in the guidelines. On the basis of these findings, the DOE is nominating the Davis Canyon site as one of five sites suitable for characterization.

  18. Environmental assessment: Davis Canyon site, Utah

    International Nuclear Information System (INIS)

    1986-05-01

    In February 1983, the US Department of Energy (DOE) identified the Davis Canyon site in Utah as one of the nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Davis Canyon site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. These evaluations were reported in draft environmental assessments (EAs), which were issued for public review and comment. After considering the comments received on the draft EAs, the DOE prepared the final EA. The Davis Canyon site is in the Paradox Basin, which is one of five distinct geohydrologic settings considering for the first repository. This setting contains one other potentially acceptable site -- the Lavender Canyon site. Although the Lavender Canyon site is suitable for site characterization, the DOE has concluded that the Davis Canyon site is the preferred site in the Paradox Basin. On the basis of the evaluations reported in this EA, the DOE has found that the Davis Canyon site is not disqualified under the guidelines. Furthermore, the DOE has found that the site is suitable for site characterization because the evidence does not support a conclusion that the site will not be able to meet each of the qualifying conditions specified in the guidelines. On the basis of these findings, the DOE is nominating the Davis Canyon site as one of five sites suitable for characterization

  19. Environmental assessment: Davis Canyon site, Utah

    International Nuclear Information System (INIS)

    1986-05-01

    In February 1983, the US Department of Energy (DOE) identified the Davis Canyon site in Utah as one of the nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high- level radioactive waste. To determine their suitability, the Davis Canyon site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. These evaluations were reported in draft environmental assessments (EAs), which were issued for public review and comment. After considering the comments received on the draft EAs, the DOE prepared the final EA. The Davis Canyon site is in the Paradox Basin, which is one of five distinct geohydrologic settings considered for the first repository. This setting contains one other potentially acceptable site -- the Lavender Canyon site. Although the Lavender Canyon site is suitable for site characterization, the DOE has concluded that the Davis Canyon site is the preferred site in the Paradox Basin. On the basis of the evaluations reported in this EA, the DOE has found that the Davis Canyon site is not disqualified under the guidelines. Furthermore, the DOE has found that the site is suitable for site characterization because the evidence does not support a conclusion that the site will not be able to meet each of the qualifying conditions specified in the guidelines. On the basis of these findings, the DOE is nominating the Davis Canyon site as one of the five sites suitable for characterization

  20. Applying the 5 WHYs to Identify Root Causes to Non-completions in On-Site Construction

    DEFF Research Database (Denmark)

    Lindhard, Søren Munch

    2014-01-01

    from mistakes. A central part of the control framework Last Planner System is to identify not completed activities to identify root causes and to learn. One tool to investigate root causes is the 5 WHYs approach. The 5 WHYs approach has been applied in a case study research to analysis the root cause...

  1. Model outputs for each hotspot site to identify the likely environmental, economic and social effects of proposed remediation strategies

    DEFF Research Database (Denmark)

    Fleskens, Luuk; Irvine, Brian; Kirkby, Mike

    2012-01-01

    Portuguese sites) a fire severity index under current conditions and under different technologies. The DESMICE model is informed by WB3 WOCAT database records, economic WB4 experimental results, additionally requested data on spatial variability of costs and benefits, and secondary data. It applies spatially...... multiple stakeholders in very different contexts into the modelling process, in order to enhance both the realism and relevance of outputs for policy and practice; b) site-selection modelling is being applied to land degradation mitigation to enable landscape-scale assessments of the most economically....... Biophysical models (e.g. PESERA) should be able to separate immediate and gradual aspects. Ongoing degradation in the without case is not yet implicitly considered. Analysis of robustness to climatic variability and prices is also essential. Finally, factors such as attitude towards conservation and risk...

  2. Pairwise comparisons of ten porcine tissues identify differential transcriptional regulation at the gene, isoform, promoter and transcription start site level

    International Nuclear Information System (INIS)

    Farajzadeh, Leila; Hornshøj, Henrik; Momeni, Jamal; Thomsen, Bo; Larsen, Knud; Hedegaard, Jakob; Bendixen, Christian; Madsen, Lone Bruhn

    2013-01-01

    Highlights: •Transcriptome sequencing yielded 223 mill porcine RNA-seq reads, and 59,000 transcribed locations. •Establishment of unique transcription profiles for ten porcine tissues including four brain tissues. •Comparison of transcription profiles at gene, isoform, promoter and transcription start site level. •Highlights a high level of regulation of neuro-related genes at both gene, isoform, and TSS level. •Our results emphasize the pig as a valuable animal model with respect to human biological issues. -- Abstract: The transcriptome is the absolute set of transcripts in a tissue or cell at the time of sampling. In this study RNA-Seq is employed to enable the differential analysis of the transcriptome profile for ten porcine tissues in order to evaluate differences between the tissues at the gene and isoform expression level, together with an analysis of variation in transcription start sites, promoter usage, and splicing. Totally, 223 million RNA fragments were sequenced leading to the identification of 59,930 transcribed gene locations and 290,936 transcript variants using Cufflinks with similarity to approximately 13,899 annotated human genes. Pairwise analysis of tissues for differential expression at the gene level showed that the smallest differences were between tissues originating from the porcine brain. Interestingly, the relative level of differential expression at the isoform level did generally not vary between tissue contrasts. Furthermore, analysis of differential promoter usage between tissues, revealed a proportionally higher variation between cerebellum (CBE) versus frontal cortex and cerebellum versus hypothalamus (HYP) than in the remaining comparisons. In addition, the comparison of differential transcription start sites showed that the number of these sites is generally increased in comparisons including hypothalamus in contrast to other pairwise assessments. A comprehensive analysis of one of the tissue contrasts, i

  3. Newly identified essential amino acid residues affecting ^8-sphingolipid desaturase activity revealed by site-directed mutagenesis

    Science.gov (United States)

    In order to identify amino acid residues crucial for the enzymatic activity of ^8-sphingolipid desaturases, a sequence comparison was performed among ^8-sphingolipid desaturases and ^6-fatty acid desaturase from various plants. In addition to the known conserved cytb5 (cytochrome b5) HPGG motif and...

  4. Mild soaps and radiotherapy: a survey of the UK public to identify brands of soap considered mild and analysis of these to ascertain suitability for recommendation in radiotherapy departments.

    Science.gov (United States)

    Robertson, K; Brown, P

    2011-05-01

    Cancer agencies recommend that patients use mild soap when undergoing external beam radiotherapy to minimise skin reactions. They define 'mild soap' as non-alkaline, lanolin free, unperfumed soap with a neutral pH. This study aimed to identify which soaps the UK public perceive as mild and ascertain if these were clinically mild and could potentially be recommended within radiotherapy departments. A survey of 237 participants identified eight top brands of mild soap, which were then tested for pH and analysed for potential irritants. All soaps were lanolin free and non-alkaline, with Simple and Johnson's the closest to pH 5.5. All contained fragrances except Simple and E45. Dove, Pears and Imperial Leather contained the highest concentration of fragrances. All soaps except E45 contained potential irritants. Only Simple and E45 fit the cancer agencies' definition of mild soap and could therefore be recommended for radiotherapy patients. Future research should identify current practices and recommendations in the UK as anecdotal evidence suggests large variations in skin care advice. Further scientific analysis could potentially identify cheaper brands that fit the definition of 'mild'. UK recommendations should be standardised and consistent with best practice to reduce skin reaction severity in radiotherapy patients. © 2010 Blackwell Publishing Ltd.

  5. Partial digestion with restriction enzymes of ultraviolet-irradiated human genomic DNA: a method for identifying restriction site polymorphisms

    International Nuclear Information System (INIS)

    Nobile, C.; Romeo, G.

    1988-01-01

    A method for partial digestion of total human DNA with restriction enzymes has been developed on the basis of a principle already utilized by P.A. Whittaker and E. Southern for the analysis of phage lambda recombinants. Total human DNA irradiated with uv light of 254 nm is partially digested by restriction enzymes that recognize sequences containing adjacent thymidines because of TT dimer formation. The products resulting from partial digestion of specific genomic regions are detected in Southern blots by genomic-unique DNA probes with high reproducibility. This procedure is rapid and simple to perform because the same conditions of uv irradiation are used for different enzymes and probes. It is shown that restriction site polymorphisms occurring in the genomic regions analyzed are recognized by the allelic partial digest patterns they determine

  6. Diet of pumas (Puma concolor) in Sonora, Mexico, as determined by GPS kill sites and molecular identified scat, with comments on jaguar (Panthera onca) diet

    Science.gov (United States)

    Cassaigne, Ivonne; Medellin, Rodrigo A.; Thompson, Ron W.; Culver, Melanie; Ochoa, Alexander; Vargas, Karla; Childs, Jack L.; Sanderson, Jim; List, Rurik; Torres-Gomez, Armando

    2016-01-01

    We documented puma (Puma concolor) and jaguar (Panthera onca) prey consumption in northeastern Sonora, Mexico, by investigating global positioning system cluster sites (n = 220), and conducting molecular analyses of scat (n = 116) collected between 2011 and 2013. We used camera trap data (n = 8,976 camera days) to estimate relative abundances of pumas and jaguars. Deer (Odocoileus virginianus) was the most frequent prey for puma found at kill sites (67%) and identified from scat (74%), although based on relative numbers of prey consumed, deer represented 45% and lagomorphs 20% of the proportion of all individuals eaten. A variety of small prey (weighing Sonora.

  7. A strategy for interaction site prediction between phospho-binding modules and their partners identified from proteomic data.

    Science.gov (United States)

    Aucher, Willy; Becker, Emmanuelle; Ma, Emilie; Miron, Simona; Martel, Arnaud; Ochsenbein, Françoise; Marsolier-Kergoat, Marie-Claude; Guerois, Raphaël

    2010-12-01

    Small and large scale proteomic technologies are providing a wealth of potential interactions between proteins bearing phospho-recognition modules and their substrates. Resulting interaction maps reveal such a dense network of interactions that the functional dissection and understanding of these networks often require to break specific interactions while keeping the rest intact. Here, we developed a computational strategy, called STRIP, to predict the precise interaction site involved in an interaction with a phospho-recognition module. The method was validated by a two-hybrid screen carried out using the ForkHead Associated (FHA)1 domain of Rad53, a key protein of Saccharomyces cerevisiae DNA checkpoint, as a bait. In this screen we detected 11 partners, including Cdc7 and Cdc45, essential components of the DNA replication machinery. FHA domains are phospho-threonine binding modules and the threonines involved in both interactions could be predicted using the STRIP strategy. The threonines T484 and T189 in Cdc7 and Cdc45, respectively, were mutated and loss of binding could be monitored experimentally with the full-length proteins. The method was further tested for the analysis of 63 known Rad53 binding partners and provided several key insights regarding the threonines likely involved in these interactions. The STRIP method relies on a combination of conservation, phosphorylation likelihood, and binding specificity criteria and can be accessed via a web interface at http://biodev.extra.cea.fr/strip/.

  8. A Strategy for Interaction Site Prediction between Phospho-binding Modules and their Partners Identified from Proteomic Data*

    Science.gov (United States)

    Aucher, Willy; Becker, Emmanuelle; Ma, Emilie; Miron, Simona; Martel, Arnaud; Ochsenbein, Françoise; Marsolier-Kergoat, Marie-Claude; Guerois, Raphaël

    2010-01-01

    Small and large scale proteomic technologies are providing a wealth of potential interactions between proteins bearing phospho-recognition modules and their substrates. Resulting interaction maps reveal such a dense network of interactions that the functional dissection and understanding of these networks often require to break specific interactions while keeping the rest intact. Here, we developed a computational strategy, called STRIP, to predict the precise interaction site involved in an interaction with a phospho-recognition module. The method was validated by a two-hybrid screen carried out using the ForkHead Associated (FHA)1 domain of Rad53, a key protein of Saccharomyces cerevisiae DNA checkpoint, as a bait. In this screen we detected 11 partners, including Cdc7 and Cdc45, essential components of the DNA replication machinery. FHA domains are phospho-threonine binding modules and the threonines involved in both interactions could be predicted using the STRIP strategy. The threonines T484 and T189 in Cdc7 and Cdc45, respectively, were mutated and loss of binding could be monitored experimentally with the full-length proteins. The method was further tested for the analysis of 63 known Rad53 binding partners and provided several key insights regarding the threonines likely involved in these interactions. The STRIP method relies on a combination of conservation, phosphorylation likelihood, and binding specificity criteria and can be accessed via a web interface at http://biodev.extra.cea.fr/strip/. PMID:20733106

  9. Surgical site infection prevention: a survey to identify the gap between evidence and practice in University of Toronto teaching hospitals.

    Science.gov (United States)

    Eskicioglu, Cagla; Gagliardi, Anna R; Fenech, Darlene S; Forbes, Shawn S; McKenzie, Marg; McLeod, Robin S; Nathens, Avery B

    2012-08-01

    A gap exists between the best evidence and practice with regards to surgical site infection (SSI) prevention. Awareness of evidence is the first step in knowledge translation. A web-based survey was distributed to 59 general surgeons and 68 residents at University of Toronto teaching hospitals. Five domains pertaining to SSI prevention with questions addressing knowledge of prevention strategies, efficacy of antibiotics, strategies for changing practice and barriers to implementation of SSI prevention strategies were investigated. Seventy-six individuals (60%) responded. More than 90% of respondents stated there was evidence for antibiotic prophylaxis and perioperative normothermia and reported use of these strategies. There was a discrepancy in the perceived evidence for and the self-reported use of perioperative hyperoxia, omission of hair removal and bowel preparation. Eighty-three percent of respondents felt that consulting published guidelines is important in making decisions regarding antibiotics. There was also a discrepancy between what respondents felt were important strategies to ensure timely administration of antibiotics and what strategies were in place. Checklists, standardized orders, protocols and formal surveillance programs were rated most highly by 75%-90% of respondents, but less than 50% stated that these strategies were in place at their institutions. Broad-reaching initiatives that increase surgeon and trainee awareness and implementation of multifaceted hospital strategies that engage residents and attending surgeons are needed to change practice.

  10. Application of multiple tracers (SF6 and chloride) to identify the transport by characteristics of contaminant at two separate contaminated sites

    Science.gov (United States)

    Lee, K. K.; Lee, S. S.; Kim, H. H.; Koh, E. H.; Kim, M. O.; Lee, K.; Kim, H. J.

    2016-12-01

    Multiple tracers were applied for source and pathway detection at two different sites. CO2 gas injected in the subsurface for a shallow-depth CO2 injection and leak test can be regarded as a potential contaminant source. Therefore, it is necessary to identify the migration pattern of CO2 gas. Also, at a DNAPL contaminated site, it is important to figure out the characteristics of plume evolution from the source zone. In this study, multiple tracers (SF6 and chloride) were used to evaluate the applicability of volatile and non-volatile tracers and to identify the characteristics of contaminant transport at each CO2 injection and leak test site and DNAPL contaminated site. Firstly, at the CO2 test site, multiple tracers were used to perform the single well push-drift-pull tracer test at total 3 specific depth zones. As results of tests, volatile and non-volatile tracers showed different mass recovery percentage. Most of chloride mass was recovered but less than half of SF6 mass was recovered due to volatile property. This means that only gaseous SF6 leak out to unsaturated zone. However, breakthrough curves of both tracers indicated similar peak time, effective porosity, and regional groundwater velocity. Also, at both contaminated sites, natural gradient tracer tests were performed with multiple tracers. With the results of natural gradient tracer test, it was possible to confirm the applicability of multiple tracers and to understand the contaminant transport in highly heterogeneous aquifer systems through the long-term monitoring of tracers. Acknowledgement: financial support was provided by the R&D Project on Environmental Management of Geologic CO2 Storage)" from the KEITI (Project Number: 2014001810003) and Korea Ministry of Environment as "The GAIA project (2014000540010)".

  11. Ensemble modeling to predict habitat suitability for a large-scale disturbance specialist

    Science.gov (United States)

    Quresh S. Latif; Victoria A. Saab; Jonathan G. Dudley; Jeff P. Hollenbeck

    2013-01-01

    To conserve habitat for disturbance specialist species, ecologists must identify where individuals will likely settle in newly disturbed areas. Habitat suitability models can predict which sites at new disturbances will most likely attract specialists. Without validation data from newly disturbed areas, however, the best approach for maximizing predictive accuracy can...

  12. A triad of lys12, lys41, arg78 spatial domain, a novel identified heparin binding site on tat protein, facilitates tat-driven cell adhesion.

    Directory of Open Access Journals (Sweden)

    Jing Ai

    Full Text Available Tat protein, released by HIV-infected cells, has a battery of important biological effects leading to distinct AIDS-associated pathologies. Cell surface heparan sulfate protoglycans (HSPGs have been accepted as endogenous Tat receptors, and the Tat basic domain has been identified as the heparin binding site. However, findings that deletion or substitution of the basic domain inhibits but does not completely eliminate Tat-heparin interactions suggest that the basic domain is not the sole Tat heparin binding site. In the current study, an approach integrating computational modeling, mutagenesis, biophysical and cell-based assays was used to elucidate a novel, high affinity heparin-binding site: a Lys12, Lys41, Arg78 (KKR spatial domain. This domain was also found to facilitate Tat-driven β1 integrin activation, producing subsequent SLK cell adhesion in an HSPG-dependent manner, but was not involved in Tat internalization. The identification of this new heparin binding site may foster further insight into the nature of Tat-heparin interactions and subsequent biological functions, facilitating the rational design of new therapeutics against Tat-mediated pathological events.

  13. Computational Characterization of Small Molecules Binding to the Human XPF Active Site and Virtual Screening to Identify Potential New DNA Repair Inhibitors Targeting the ERCC1-XPF Endonuclease

    Directory of Open Access Journals (Sweden)

    Francesco Gentile

    2018-04-01

    Full Text Available The DNA excision repair protein ERCC-1-DNA repair endonuclease XPF (ERCC1-XPF is a heterodimeric endonuclease essential for the nucleotide excision repair (NER DNA repair pathway. Although its activity is required to maintain genome integrity in healthy cells, ERCC1-XPF can counteract the effect of DNA-damaging therapies such as platinum-based chemotherapy in cancer cells. Therefore, a promising approach to enhance the effect of these therapies is to combine their use with small molecules, which can inhibit the repair mechanisms in cancer cells. Currently, there are no structures available for the catalytic site of the human ERCC1-XPF, which performs the metal-mediated cleavage of a DNA damaged strand at 5′. We adopted a homology modeling strategy to build a structural model of the human XPF nuclease domain which contained the active site and to extract dominant conformations of the domain using molecular dynamics simulations followed by clustering of the trajectory. We investigated the binding modes of known small molecule inhibitors targeting the active site to build a pharmacophore model. We then performed a virtual screening of the ZINC Is Not Commercial 15 (ZINC15 database to identify new ERCC1-XPF endonuclease inhibitors. Our work provides structural insights regarding the binding mode of small molecules targeting the ERCC1-XPF active site that can be used to rationally optimize such compounds. We also propose a set of new potential DNA repair inhibitors to be considered for combination cancer therapy strategies.

  14. Initial direct comparison of 99mTc-TOC and 99mTc-TATE in identifying sites of disease in patients with proven GEP NETs.

    Science.gov (United States)

    Cwikla, Jaroslaw B; Mikolajczak, Renata; Pawlak, Dariusz; Buscombe, John R; Nasierowska-Guttmejer, Anna; Bator, Andrzej; Maecke, Helmut R; Walecki, Jerzy

    2008-07-01

    The imaging of neuroendocrine tumors has become one of the most significant areas in nuclear oncology. In an attempt to provide high-quality imaging and possible sensitivity at a reduced cost, time, and radiation dose, several (99m)Tc agents have been proposed. The aim of this initial study was to compare the tumor uptake and biodistribution of 2 new 6-hydrazinopyridine-3-carboxylic acid (HYNIC)-derivatized Tyr(3)-octreotide analogs, (99m)Tc-[HYNIC,Tyr(3)]octreotide ((99m)Tc-TOC) and (99m)Tc-[HYNIC,Tyr(3),Thr(8)]octreotide ((99m)Tc-TATE), in patients with somatostatin receptor-expressing tumors. Each of 12 patients with proven gastrointestinal pancreatic neuroendocrine tumors received a mean activity of 520 MBq of (99m)Tc-TOC and (99m)Tc-TATE. Scintigraphy with both tracers was performed 3-4 h after their injection using standard whole-body and SPECT imaging. The images were reviewed subjectively by 2 readers, who reported tumor uptake lesion by lesion. Both radiotracers demonstrated concordance between the results in 7 patients (58%). In total, 110 sites of disease were identified with (99m)Tc-TOC, compared with 115 with (99m)Tc-TATE. There was 1 case in which (99m)Tc-TOC identified sites of disease not seen on (99m)Tc-TATE imaging but 4 cases in which some sites of disease were seen with (99m)Tc-TATE and not (99m)Tc-TOC. In this initial study, both tracers seem to show similar sites of tumor, with (99m)Tc-TATE having a slight edge in the total number of lesions seen, especially in lymph node metastases.

  15. Exome Sequencing Identified a Splice Site Mutation in FHL1 that Causes Uruguay Syndrome, an X-Linked Disorder With Skeletal Muscle Hypertrophy and Premature Cardiac Death.

    Science.gov (United States)

    Xue, Yuan; Schoser, Benedikt; Rao, Aliz R; Quadrelli, Roberto; Vaglio, Alicia; Rupp, Verena; Beichler, Christine; Nelson, Stanley F; Schapacher-Tilp, Gudrun; Windpassinger, Christian; Wilcox, William R

    2016-04-01

    Previously, we reported a rare X-linked disorder, Uruguay syndrome in a single family. The main features are pugilistic facies, skeletal deformities, and muscular hypertrophy despite a lack of exercise and cardiac ventricular hypertrophy leading to premature death. An ≈19 Mb critical region on X chromosome was identified through identity-by-descent analysis of 3 affected males. Exome sequencing was conducted on one affected male to identify the disease-causing gene and variant. A splice site variant (c.502-2A>G) in the FHL1 gene was highly suspicious among other candidate genes and variants. FHL1A is the predominant isoform of FHL1 in cardiac and skeletal muscle. Sequencing cDNA showed the splice site variant led to skipping of exons 6 of the FHL1A isoform, equivalent to the FHL1C isoform. Targeted analysis showed that this splice site variant cosegregated with disease in the family. Western blot and immunohistochemical analysis of muscle from the proband showed a significant decrease in protein expression of FHL1A. Real-time polymerase chain reaction analysis of different isoforms of FHL1 demonstrated that the FHL1C is markedly increased. Mutations in the FHL1 gene have been reported in disorders with skeletal and cardiac myopathy but none has the skeletal or facial phenotype seen in patients with Uruguay syndrome. Our data suggest that a novel FHL1 splice site variant results in the absence of FHL1A and the abundance of FHL1C, which may contribute to the complex and severe phenotype. Mutation screening of the FHL1 gene should be considered for patients with uncharacterized myopathies and cardiomyopathies. © 2016 American Heart Association, Inc.

  16. Tandem affinity purification of histones, coupled to mass spectrometry, identifies associated proteins and new sites of post-translational modification in Saccharomyces cerevisiae.

    Science.gov (United States)

    Valero, M Luz; Sendra, Ramon; Pamblanco, Mercè

    2016-03-16

    Histones and their post-translational modifications contribute to regulating fundamental biological processes in all eukaryotic cells. We have applied a conventional tandem affinity purification strategy to histones H3 and H4 of the yeast Saccharomyces cerevisiae. Mass spectrometry analysis of the co-purified proteins revealed multiple associated proteins, including core histones, which indicates that tagged histones may be incorporated to the nucleosome particle. Among the many other co-isolated proteins there are histone chaperones, elements of chromatin remodeling, of nucleosome assembly/disassembly, and of histone modification complexes. The histone chaperone Rtt106p, two members of chromatin assembly FACT complex and Psh1p, an ubiquitin ligase, were the most abundant proteins obtained with both H3-TAP and H4-TAP, regardless of the cell extraction medium stringency. Our mass spectrometry analyses have also revealed numerous novel post-translational modifications, including 30 new chemical modifications in histones, mainly by ubiquitination. We have discovered not only new sites of ubiquitination but that, besides lysine, also serine and threonine residues are targets of ubiquitination on yeast histones. Our results show the standard tandem affinity purification procedure is suitable for application to yeast histones, in order to isolate and characterize histone-binding proteins and post-translational modifications, avoiding the bias caused by histone purification from a chromatin-enriched fraction. Copyright © 2016 Elsevier B.V. All rights reserved.

  17. Rhodium(II) Proximity-Labeling Identifies a Novel Target Site on STAT3 for Inhibitors with Potent Anti-Leukemia Activity.

    Science.gov (United States)

    Minus, Matthew B; Liu, Wei; Vohidov, Farrukh; Kasembeli, Moses M; Long, Xin; Krueger, Michael J; Stevens, Alexandra; Kolosov, Mikhail I; Tweardy, David J; Sison, Edward Allan R; Redell, Michele S; Ball, Zachary T

    2015-10-26

    Nearly 40 % of children with acute myeloid leukemia (AML) suffer relapse arising from chemoresistance, often involving upregulation of the oncoprotein STAT3 (signal transducer and activator of transcription 3). Herein, rhodium(II)-catalyzed, proximity-driven modification identifies the STAT3 coiled-coil domain (CCD) as a novel ligand-binding site, and we describe a new naphthalene sulfonamide inhibitor that targets the CCD, blocks STAT3 function, and halts its disease-promoting effects in vitro, in tumor growth models, and in a leukemia mouse model, validating this new therapeutic target for resistant AML. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  18. Habitat suitability index model of the sea cucumber Apostichopus japonicus (Selenka): A case study of Shandong Peninsula, China.

    Science.gov (United States)

    Zhang, Zhipeng; Zhou, Jian; Song, Jingjing; Wang, Qixiang; Liu, Hongjun; Tang, Xuexi

    2017-09-15

    A habitat suitability index (HSI) model for the sea cucumber Apostichopus japonicus (Selenka) was established in the present study. Based on geographic information systems, the HSI model was used to identify potential sites around the Shandong Peninsula suitable for restoration of immature (25g) A. japonicus. Six habitat factors were used as input variables for the HSI model: sediment classification, water temperature, salinity, water depth, pH and dissolved oxygen. The weighting of each habitat factor was defined through the Delphi method. Sediment classification was the most important condition affecting the HSI of A. japonicus in the different study areas, while water temperature was the most important condition in different seasons. The HSI of Western Laizhou Bay was relatively low, meaning the site was not suitable for aquaculture-based restoration of A. japonicus. In contrast, Xiaoheishan Island, Rongcheng Bay and Qingdao were preferable sites, suitable as habitats for restoration efforts. Copyright © 2017 Elsevier Ltd. All rights reserved.

  19. Environmental assessment overview, Davis Canyon site, Utah

    International Nuclear Information System (INIS)

    1986-05-01

    In February 1983, the US Department of Energy (DOE) identified the Davis Canyon site in Utah as one of the nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Davis Canyon site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. The Davis Canyon site is in the Paradox Basin, which is one of five distinct geohydrologic settings considered for the first repository. On the basis of the evaluations reported in this EA, the DOE has found that the Davis Canyon site is not disqualified under the guidelines. On the basis of these findings, the DOE is nominating the Davis Canyon site as one of five sites suitable for characterization. 3 figs

  20. Environmental assessment overview: Richton Dome site, Mississippi

    International Nuclear Information System (INIS)

    1986-05-01

    In February 1983, the US Department of Energy (DOE) identified the Richton Dome site in Mississippi as one of the nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Richton Dome site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. The site is in the Gulf interior region, which is one of five distinct geohydrologic settings considered for the first repository. On the basis of the evaluations reported in this EA, the DOE has found that the Richton Dome site is not disqualified under the guidelines. On the basis of these findings, the DOE is nominating the Richton Dome site as one of five sites suitable for characterization. 3 figs

  1. Use of Anisotropy, 3D Segmented Atlas, and Computational Analysis to Identify Gray Matter Subcortical Lesions Common to Concussive Injury from Different Sites on the Cortex.

    Directory of Open Access Journals (Sweden)

    Praveen Kulkarni

    Full Text Available Traumatic brain injury (TBI can occur anywhere along the cortical mantel. While the cortical contusions may be random and disparate in their locations, the clinical outcomes are often similar and difficult to explain. Thus a question that arises is, do concussions at different sites on the cortex affect similar subcortical brain regions? To address this question we used a fluid percussion model to concuss the right caudal or rostral cortices in rats. Five days later, diffusion tensor MRI data were acquired for indices of anisotropy (IA for use in a novel method of analysis to detect changes in gray matter microarchitecture. IA values from over 20,000 voxels were registered into a 3D segmented, annotated rat atlas covering 150 brain areas. Comparisons between left and right hemispheres revealed a small population of subcortical sites with altered IA values. Rostral and caudal concussions were of striking similarity in the impacted subcortical locations, particularly the central nucleus of the amygdala, laterodorsal thalamus, and hippocampal complex. Subsequent immunohistochemical analysis of these sites showed significant neuroinflammation. This study presents three significant findings that advance our understanding and evaluation of TBI: 1 the introduction of a new method to identify highly localized disturbances in discrete gray matter, subcortical brain nuclei without postmortem histology, 2 the use of this method to demonstrate that separate injuries to the rostral and caudal cortex produce the same subcortical, disturbances, and 3 the central nucleus of the amygdala, critical in the regulation of emotion, is vulnerable to concussion.

  2. An approach for recreation suitability analysis to recreation planning in Gölcük Nature Park.

    Science.gov (United States)

    Gül, Atila; Orücü, M Kamil; Karaca, Oznur

    2006-05-01

    Gölcük Nature Park (GNP) is an area protected by law in Turkey. It is an important nature park with rich flora, fauna, geomorphologic forms, landscape features, and recreational potential in the region. However, GNP does not have a recreation management plan. The purpose of this study was to determine the actual natural, cultural, and visual resources of GNP, determine the most suitable recreational sites with multiple factors, evaluate the demands and tendencies of visitors, and suggest recreational activities and facilities for the most suitable sites of GNP. However, it was also conceived as leading to a recreational plan and design of GNP in the future and identifying the entire appropriate and current data of GNP with the creation of various maps. This study used multifactor analysis to determine the most suitable recreation sites of GNP. Used recreation factors were established including degree of slope, proximity to water resources, accessibility, elevation, vegetation, soil, climate, aspect, current cultural facilities, visual values, and some limiting factors in accordance with the characteristics of GNP. Weighting and suitability values of factors were determined by 30 local expert surveys. All obtained data were evaluated and integrated in the Geographical Information Systems base. Obtained maps were overlapped. Thus, recreational suitability zones map were created manually. However, the demands and behaviours from visitor surveys in GNP were focused on the most suitable recreation sites of the park. Finally, 10% of GNP was identified as the most suitable sites for recreational use. Various recreational facilities and activities (including picnicking, sports facilities and playgrounds, camping sites, walking paths, food and local outlets, etc.) were recommended for nine of the most suitable areas on the proposed recreational map.

  3. Identifying the Infection Control Areas Requiring Modifications in Thoracic Surgery Units: Results of a Two-Year Surveillance of Surgical Site Infections in Hospitals in Southern Poland.

    Science.gov (United States)

    Dubiel, Grzegorz; Rogoziński, Paweł; Żaloudik, Elżbieta; Bruliński, Krzysztof; Różańska, Anna; Wójkowska-Mach, Jadwiga

    2017-10-01

    Surgical site infection (SSI) is considered to be a priority in infection control. The objective of this study is the analysis of results of active targeted surveillance conducted over a two-year period in the Department of Thoracic Surgery at the Pulmonology and Thoracic Surgery Center in Bystra, in southern Poland. The retrospective analysis was carried out on the basis of results of active monitoring of SSI in the 45-bed Department of Thoracic Surgery at the Pulmonology and Thoracic Surgery Center in Bystra between April 1, 2014 and April 30, 2016. Surgical site infections were identified based on the definitions of the European Centre for Disease Prevention and Control (ECDC) taking into account the time of symptom onset, specifically, whether the symptoms occurred within 30 d after the surgical procedure. Detection of SSI relied on daily inspection of incisions by a trained nurse, analysis of medical and nursing entries in the computer system, and analysis of all results of microbiologic tests taken in the unit and in the operating room. In the study period, data were collected regarding 1,387 treatment procedures meeting the registration criteria. Forty cases of SSI were detected yielding an incidence rate of 3%. Most cases (55%) were found in the course of hospitalization and 45% were detected after the patient's discharge. The SSIs were classified as follows: superficial, 37.5%; deep infections, 7.5%; and organ/space infection, 55%. Among patients who were diagnosed with SSI, most were male (77.5%). For patients with an American Society of Anesthesiologists (ASA) score I-II the incidence rate was 2%; ASA score III or more, 3.7%. The incidence rate varied from 0.3% in clean surgical site to 6.5% in clean-contaminated site. The study validated the usefulness of targeted surveillance in monitoring SSIs in patients hospitalized in thoracic surgery departments. Surgical site infection surveillance identified areas of care requiring modifications, namely

  4. Environmental assessment: Deaf Smith County site, Texas

    International Nuclear Information System (INIS)

    1986-05-01

    In February 1983, the US Department of Energy (DOE) identified a location in Deaf Smith County, Texas, as one of nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Deaf Smith County site and the eight other potentially sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. The Deaf Smith County site is in the Permian Basin, which is one of five distinct geohydrologic settings considered for the first repository. On the basis of the evaluations reported in this EA, the DOE has found that the Deaf Smith County site is not disqualified under the guidelines. On the basis of these findings, the DOE is nominating the Deaf Smith County site as one of the five sites suitable for characterization. 591 refs., 147 figs., 173 tabs

  5. Environmental assessment: Deaf Smith County site, Texas

    Energy Technology Data Exchange (ETDEWEB)

    1986-05-01

    In February 1983, the US Department of Energy (DOE) identified a location in Deaf Smith County, Texas, as one of nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Deaf Smith County site and the eight other potentially sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. The Deaf Smith County site is in the Permian Basin, which is one of five distinct geohydrologic settings considered for the first repository. On the basis of the evaluations reported in this EA, the DOE has found that the Deaf Smith County site is not disqualified under the guidelines. On the basis of these findings, the DOE is nominating the Deaf Smith County site as one of the five sites suitable for characterization. 591 refs., 147 figs., 173 tabs.

  6. In Silico Analysis of Gene Expression Network Components Underlying Pigmentation Phenotypes in the Python Identified Evolutionarily Conserved Clusters of Transcription Factor Binding Sites

    Directory of Open Access Journals (Sweden)

    Kristopher J. L. Irizarry

    2016-01-01

    Full Text Available Color variation provides the opportunity to investigate the genetic basis of evolution and selection. Reptiles are less studied than mammals. Comparative genomics approaches allow for knowledge gained in one species to be leveraged for use in another species. We describe a comparative vertebrate analysis of conserved regulatory modules in pythons aimed at assessing bioinformatics evidence that transcription factors important in mammalian pigmentation phenotypes may also be important in python pigmentation phenotypes. We identified 23 python orthologs of mammalian genes associated with variation in coat color phenotypes for which we assessed the extent of pairwise protein sequence identity between pythons and mouse, dog, horse, cow, chicken, anole lizard, and garter snake. We next identified a set of melanocyte/pigment associated transcription factors (CREB, FOXD3, LEF-1, MITF, POU3F2, and USF-1 that exhibit relatively conserved sequence similarity within their DNA binding regions across species based on orthologous alignments across multiple species. Finally, we identified 27 evolutionarily conserved clusters of transcription factor binding sites within ~200-nucleotide intervals of the 1500-nucleotide upstream regions of AIM1, DCT, MC1R, MITF, MLANA, OA1, PMEL, RAB27A, and TYR from Python bivittatus. Our results provide insight into pigment phenotypes in pythons.

  7. Elk habitat suitability map for North Carolina

    Science.gov (United States)

    Williams, Steven G.; Cobb, David T.; Collazo, Jaime A.

    2015-01-01

    Although eastern elk (Cervus elaphus canadensis) were extirpated from the eastern United States in the 19th century, they were successfully reintroduced in the North Carolina portion of the Great Smoky Mountains National Park in the early 2000s. The North Carolina Wildlife Resources Commission (NCWRC) is evaluating the prospect of reintroducing the species in other locations in the state to augment recreational opportunities. As a first step in the process, we created a state-wide elk habitat suitability map. We used medium-scale data sets and a two-component approach to iden- tify areas of high biological value for elk and exclude from consideration areas where elk-human conflicts were more likely. Habitats in the state were categorized as 66% unsuitable, 16.7% low, 17% medium, and <1% high suitability for elk. The coastal plain and Piedmont contained the most suitable habitat, but prospective reintroduction sites were largely excluded from consideration due to extensive agricultural activities and pervasiveness of secondary roads. We ranked 31 areas (≥ 500 km2) based on their suitability for reintroduction. The central region of the state contained the top five ranked areas. The Blue Ridge Mountains, where the extant population of elk occurs, was ranked 21st. Our work provides a benchmark for decision makers to evaluate potential consequences and trade-offs associated with the selection of prospective elk reintroduction sites.

  8. Midyear FY 1983 Richton Dome screening and suitability review

    International Nuclear Information System (INIS)

    1983-08-01

    The NWTS screening of Gulf Coast salt domes for suitable nuclear waste repository sites identified three candidate domes. These are, in order of preference, Richton Dome, Mississippi; Vacherie Dome, Louisiana; and Cypress Creek Dome, Mississippi. A qualitative review of information obtained since this initial ranking gives no basis for revising this ranking. A review of unresolved siting issues at Richton Dome shows siting concerns presently center on the geologic stability and hydrology suitability of Richton Dome and vicinity. Tectonic concerns of regional uplift and faulting are examined, as are salt tectonic concerns related to salt dome movement and dissolution. Both geologic and geodetic data suggest the Mississippi Salt Basin is experiencing uplift. However, uplift rates estimated from geologic evidence are an order of magnitude less than rates estimated from releveling data. Faults are present throughout much of the basin, and most are the result of horizontal and vertical movements of the Louann Salt during the Cretaceous and Early Tertiary. Several faults are present in the sediments surrounding Richton Dome, but current evidence suggests no movements have occurred since the Miocene. Richton Dome's hydrologic suitability is considered in analysis of the regional ground-water flow system. A three-dimensional, ground-water flow model has been utilized to calculate travel paths and travel times for releases of contaminants from various points on the dome. Based on model analyses, a release at repository level would take nearly 39,000 years to reach the upper aquifer and would eventually discharge into the Leaf River or upper reaches of the Pascagoula River over 50 km from the dome. This estimate of travel time greatly exceeds the minimum 1000 year travel time required by proposed Department of Energy (DOE) guidelines. 76 references

  9. Web page classification on child suitability

    NARCIS (Netherlands)

    C. Eickhoff (Carsten); P. Serdyukov; A.P. de Vries (Arjen)

    2010-01-01

    htmlabstractChildren spend significant amounts of time on the Internet. Recent studies showed, that during these periods they are often not under adult supervision. This work presents an automatic approach to identifying suitable web pages for children based on topical and non-topical web page

  10. Mass spectrometry and site-directed mutagenesis identify several autophosphorylated residues required for the activity of PrkC, a Ser/Thr kinase from Bacillus subtilis

    DEFF Research Database (Denmark)

    Madec, Edwige; Stensballe, Allan; Kjellström, Sven

    2003-01-01

    We have shown recently that PrkC, which is involved in developmental processes in Bacillus subtilis, is a Ser/Thr kinase with features of the receptor kinase family of eukaryotic Hanks kinases. In this study, we expressed and purified from Escherichia coli the cytoplasmic domain of PrkC containing...... the kinase and a short juxtamembrane region. This fragment, which we designate PrkCc, undergoes autophosphorylation in E.coli. PrkCc is further autophosphorylated in vitro, apparently through a trans-kinase, intermolecular reaction. PrkC also displays kinase activity with myelin basic protein. Using high...... mass accuracy electrospray tandem mass spectrometry (LC-MS/MS) and nanoelectrospray tandem mass spectrometry, we identified seven phosphorylated threonine and one serine residue in PrkCc. All the corresponding residues were replaced by systematic site-directed mutagenesis and the purified mutant...

  11. Site-Mutation of Hydrophobic Core Residues Synchronically Poise Super Interleukin 2 for Signaling: Identifying Distant Structural Effects through Affordable Computations

    Directory of Open Access Journals (Sweden)

    Longcan Mei

    2018-03-01

    Full Text Available A superkine variant of interleukin-2 with six site mutations away from the binding interface developed from the yeast display technique has been previously characterized as undergoing a distal structure alteration which is responsible for its super-potency and provides an elegant case study with which to get insight about how to utilize allosteric effect to achieve desirable protein functions. By examining the dynamic network and the allosteric pathways related to those mutated residues using various computational approaches, we found that nanosecond time scale all-atom molecular dynamics simulations can identify the dynamic network as efficient as an ensemble algorithm. The differentiated pathways for the six core residues form a dynamic network that outlines the area of structure alteration. The results offer potentials of using affordable computing power to predict allosteric structure of mutants in knowledge-based mutagenesis.

  12. Structure-guided approach identifies a novel class of HIV-1 ribonuclease H inhibitors: binding mode insights through magnesium complexation and site-directed mutagenesis studies

    DEFF Research Database (Denmark)

    Poongavanam, Vasanthanathan; Corona, Angela; Steinmann, Casper

    2018-01-01

    is a long and expensive process that can be speeded up by in silico methods. In the present study, a structure-guided screening is coupled with a similarity-based search on the Specs database to identify a new class of HIV-1 RNase H inhibitors. Out of the 45 compounds selected for experimental testing, 15...... inhibited the RNase H function below 100 μM with three hits exhibiting IC50 values active compound, AA, inhibits HIV-1 RNase H with an IC50 of 5.1 μM and exhibits a Mg-independent mode of inhibition. Site-directed mutagenesis studies provide valuable insight into the binding mode of newly...

  13. Dominant mutations in S. cerevisiae PMS1 identify the Mlh1-Pms1 endonuclease active site and an exonuclease 1-independent mismatch repair pathway.

    Directory of Open Access Journals (Sweden)

    Catherine E Smith

    2013-10-01

    Full Text Available Lynch syndrome (hereditary nonpolypsis colorectal cancer or HNPCC is a common cancer predisposition syndrome. Predisposition to cancer in this syndrome results from increased accumulation of mutations due to defective mismatch repair (MMR caused by a mutation in one of the mismatch repair genes MLH1, MSH2, MSH6 or PMS2/scPMS1. To better understand the function of Mlh1-Pms1 in MMR, we used Saccharomyces cerevisiae to identify six pms1 mutations (pms1-G683E, pms1-C817R, pms1-C848S, pms1-H850R, pms1-H703A and pms1-E707A that were weakly dominant in wild-type cells, which surprisingly caused a strong MMR defect when present on low copy plasmids in an exo1Δ mutant. Molecular modeling showed these mutations caused amino acid substitutions in the metal coordination pocket of the Pms1 endonuclease active site and biochemical studies showed that they inactivated the endonuclease activity. This model of Mlh1-Pms1 suggested that the Mlh1-FERC motif contributes to the endonuclease active site. Consistent with this, the mlh1-E767stp mutation caused both MMR and endonuclease defects similar to those caused by the dominant pms1 mutations whereas mutations affecting the predicted metal coordinating residue Mlh1-C769 had no effect. These studies establish that the Mlh1-Pms1 endonuclease is required for MMR in a previously uncharacterized Exo1-independent MMR pathway.

  14. Dominant mutations in S. cerevisiae PMS1 identify the Mlh1-Pms1 endonuclease active site and an exonuclease 1-independent mismatch repair pathway.

    Science.gov (United States)

    Smith, Catherine E; Mendillo, Marc L; Bowen, Nikki; Hombauer, Hans; Campbell, Christopher S; Desai, Arshad; Putnam, Christopher D; Kolodner, Richard D

    2013-10-01

    Lynch syndrome (hereditary nonpolypsis colorectal cancer or HNPCC) is a common cancer predisposition syndrome. Predisposition to cancer in this syndrome results from increased accumulation of mutations due to defective mismatch repair (MMR) caused by a mutation in one of the mismatch repair genes MLH1, MSH2, MSH6 or PMS2/scPMS1. To better understand the function of Mlh1-Pms1 in MMR, we used Saccharomyces cerevisiae to identify six pms1 mutations (pms1-G683E, pms1-C817R, pms1-C848S, pms1-H850R, pms1-H703A and pms1-E707A) that were weakly dominant in wild-type cells, which surprisingly caused a strong MMR defect when present on low copy plasmids in an exo1Δ mutant. Molecular modeling showed these mutations caused amino acid substitutions in the metal coordination pocket of the Pms1 endonuclease active site and biochemical studies showed that they inactivated the endonuclease activity. This model of Mlh1-Pms1 suggested that the Mlh1-FERC motif contributes to the endonuclease active site. Consistent with this, the mlh1-E767stp mutation caused both MMR and endonuclease defects similar to those caused by the dominant pms1 mutations whereas mutations affecting the predicted metal coordinating residue Mlh1-C769 had no effect. These studies establish that the Mlh1-Pms1 endonuclease is required for MMR in a previously uncharacterized Exo1-independent MMR pathway.

  15. Radiation Therapy Deficiencies Identified During On-Site Dosimetry Visits by the Imaging and Radiation Oncology Core Houston Quality Assurance Center.

    Science.gov (United States)

    Kry, Stephen F; Dromgoole, Lainy; Alvarez, Paola; Leif, Jessica; Molineu, Andrea; Taylor, Paige; Followill, David S

    2017-12-01

    To review the dosimetric, mechanical, and programmatic deficiencies most frequently observed during on-site visits of radiation therapy facilities by the Imaging and Radiation Oncology Core Quality Assurance Center in Houston (IROC Houston). The findings of IROC Houston between 2000 and 2014, including 409 institutions and 1020 linear accelerators (linacs), were compiled. On-site evaluations by IROC Houston include verification of absolute calibration (tolerance of ±3%), relative dosimetric review (tolerances of ±2% between treatment planning system [TPS] calculation and measurement), mechanical evaluation (including multileaf collimator and kilovoltage-megavoltage isocenter evaluation against Task Group [TG]-142 tolerances), and general programmatic review (including institutional quality assurance program vs TG-40 and TG-142). An average of 3.1 deficiencies was identified at each institution visited, a number that has decreased slightly with time. The most common errors are tabulated and include TG-40/TG-142 compliance (82% of institutions were deficient), small field size output factors (59% of institutions had errors ≥3%), and wedge factors (33% of institutions had errors ≥3%). Dosimetric errors of ≥10%, including in beam calibration, were seen at many institutions. There is substantial room for improvement of both dosimetric and programmatic issues in radiation therapy, which should be a high priority for the medical physics community. Particularly relevant was suboptimal beam modeling in the TPS and a corresponding failure to detect these errors by not including TPS data in the linac quality assurance process. Copyright © 2017 Elsevier Inc. All rights reserved.

  16. Quantitative in vivo analyses reveal calcium-dependent phosphorylation sites and identifies a novel component of the Toxoplasma invasion motor complex.

    Directory of Open Access Journals (Sweden)

    Thomas Nebl

    2011-09-01

    Full Text Available Apicomplexan parasites depend on the invasion of host cells for survival and proliferation. Calcium-dependent signaling pathways appear to be essential for micronemal release and gliding motility, yet the target of activated kinases remains largely unknown. We have characterized calcium-dependent phosphorylation events during Toxoplasma host cell invasion. Stimulation of live tachyzoites with Ca²⁺-mobilizing drugs leads to phosphorylation of numerous parasite proteins, as shown by differential 2-DE display of ³²[P]-labeled protein extracts. Multi-dimensional Protein Identification Technology (MudPIT identified ∼546 phosphorylation sites on over 300 Toxoplasma proteins, including 10 sites on the actomyosin invasion motor. Using a Stable Isotope of Amino Acids in Culture (SILAC-based quantitative LC-MS/MS analyses we monitored changes in the abundance and phosphorylation of the invasion motor complex and defined Ca²⁺-dependent phosphorylation patterns on three of its components--GAP45, MLC1 and MyoA. Furthermore, calcium-dependent phosphorylation of six residues across GAP45, MLC1 and MyoA is correlated with invasion motor activity. By analyzing proteins that appear to associate more strongly with the invasion motor upon calcium stimulation we have also identified a novel 15-kDa Calmodulin-like protein that likely represents the MyoA Essential Light Chain of the Toxoplasma invasion motor. This suggests that invasion motor activity could be regulated not only by phosphorylation but also by the direct binding of calcium ions to this new component.

  17. Multi-species comparative analysis of the equine ACE gene identifies a highly conserved potential transcription factor binding site in intron 16.

    Science.gov (United States)

    Hamilton, Natasha A; Tammen, Imke; Raadsma, Herman W

    2013-01-01

    Angiotensin converting enzyme (ACE) is essential for control of blood pressure. The human ACE gene contains an intronic Alu indel (I/D) polymorphism that has been associated with variation in serum enzyme levels, although the functional mechanism has not been identified. The polymorphism has also been associated with cardiovascular disease, type II diabetes, renal disease and elite athleticism. We have characterized the ACE gene in horses of breeds selected for differing physical abilities. The equine gene has a similar structure to that of all known mammalian ACE genes. Nine common single nucleotide polymorphisms (SNPs) discovered in pooled DNA were found to be inherited in nine haplotypes. Three of these SNPs were located in intron 16, homologous to that containing the Alu polymorphism in the human. A highly conserved 18 bp sequence, also within that intron, was identified as being a potential binding site for the transcription factors Oct-1, HFH-1 and HNF-3β, and lies within a larger area of higher than normal homology. This putative regulatory element may contribute to regulation of the documented inter-individual variation in human circulating enzyme levels, for which a functional mechanism is yet to be defined. Two equine SNPs occurred within the conserved area in intron 16, although neither of them disrupted the putative binding site. We propose a possible regulatory mechanism of the ACE gene in mammalian species which was previously unknown. This advance will allow further analysis leading to a better understanding of the mechanisms underpinning the associations seen between the human Alu polymorphism and enzyme levels, cardiovascular disease states and elite athleticism.

  18. Multi-species comparative analysis of the equine ACE gene identifies a highly conserved potential transcription factor binding site in intron 16.

    Directory of Open Access Journals (Sweden)

    Natasha A Hamilton

    Full Text Available Angiotensin converting enzyme (ACE is essential for control of blood pressure. The human ACE gene contains an intronic Alu indel (I/D polymorphism that has been associated with variation in serum enzyme levels, although the functional mechanism has not been identified. The polymorphism has also been associated with cardiovascular disease, type II diabetes, renal disease and elite athleticism. We have characterized the ACE gene in horses of breeds selected for differing physical abilities. The equine gene has a similar structure to that of all known mammalian ACE genes. Nine common single nucleotide polymorphisms (SNPs discovered in pooled DNA were found to be inherited in nine haplotypes. Three of these SNPs were located in intron 16, homologous to that containing the Alu polymorphism in the human. A highly conserved 18 bp sequence, also within that intron, was identified as being a potential binding site for the transcription factors Oct-1, HFH-1 and HNF-3β, and lies within a larger area of higher than normal homology. This putative regulatory element may contribute to regulation of the documented inter-individual variation in human circulating enzyme levels, for which a functional mechanism is yet to be defined. Two equine SNPs occurred within the conserved area in intron 16, although neither of them disrupted the putative binding site. We propose a possible regulatory mechanism of the ACE gene in mammalian species which was previously unknown. This advance will allow further analysis leading to a better understanding of the mechanisms underpinning the associations seen between the human Alu polymorphism and enzyme levels, cardiovascular disease states and elite athleticism.

  19. Monoclonal antibody OKB7, which identifies the 14OKd complement receptor type 2 (CR/sub 2/), also identifies a 72Kd secreted fragment of CR/sub 2/ that contains the C3d-binding site

    Energy Technology Data Exchange (ETDEWEB)

    Myones, B.L.; Ross, G.D.

    1986-03-05

    CR/sub 2/ is a 140-145Kd glycoprotein expressed on B lymphocytes which binds both C3d and Epstein-Barr virus (EBV). OKB7, an IgG/sub 2a/ monoclonal antibody to CR/sub 2/, blocks C3d and EBV binding, while HB-5, another monoclonal IgG/sub 2a/ anti-CR/sub 2/, does not. A 72Kd C3d-binding glycoprotein (gp72), isolated from Raji cell media, was previously thought to be CR/sub 2/ because a polyclonal rabbit anti-gp72 inhibited EC3d rosettes. ELISA assay demonstrated that OKB7, but not HB-5, bound to purified gp72 fixed to microtiter wells. Insoluble and soluble gp72 blocked Raji cell uptake of /sup 125/I-labeled OKB7, but not labeled anti-B2 or HB-5. Rabbit anti-gp72 immunoprecipitated bands at 140Kd and 72Kd from /sup 125/I-labelled and solubilized B cell membranes. Culture media from Raji cells grown in the presence /sup 3/H-labeled amino acids was sequentially immunoprecipitated by irrelevant antibody, OKB7, and HB-5. A single 72Kd radiolabeled band was demonstrated only with OKB7, and this was identical to that produced by the immunoprecipitation of /sup 125/I-labeled gp72 with rabbit anti-gp72. Thus, OKB7, which identifies the 140Kd CR/sub 2/ molecule, also identifies a 72Kd shed fragment of CR/sub 2/ isolated from Raji cell media, which contains the C3d-binding site.

  20. Monoclonal antibody OKB7, which identifies the 14OKd complement receptor type 2 (CR2), also identifies a 72Kd secreted fragment of CR2 that contains the C3d-binding site

    International Nuclear Information System (INIS)

    Myones, B.L.; Ross, G.D.

    1986-01-01

    CR 2 is a 140-145Kd glycoprotein expressed on B lymphocytes which binds both C3d and Epstein-Barr virus (EBV). OKB7, an IgG/sub 2a/ monoclonal antibody to CR 2 , blocks C3d and EBV binding, while HB-5, another monoclonal IgG/sub 2a/ anti-CR 2 , does not. A 72Kd C3d-binding glycoprotein (gp72), isolated from Raji cell media, was previously thought to be CR 2 because a polyclonal rabbit anti-gp72 inhibited EC3d rosettes. ELISA assay demonstrated that OKB7, but not HB-5, bound to purified gp72 fixed to microtiter wells. Insoluble and soluble gp72 blocked Raji cell uptake of 125 I-labeled OKB7, but not labeled anti-B2 or HB-5. Rabbit anti-gp72 immunoprecipitated bands at 140Kd and 72Kd from 125 I-labelled and solubilized B cell membranes. Culture media from Raji cells grown in the presence 3 H-labeled amino acids was sequentially immunoprecipitated by irrelevant antibody, OKB7, and HB-5. A single 72Kd radiolabeled band was demonstrated only with OKB7, and this was identical to that produced by the immunoprecipitation of 125 I-labeled gp72 with rabbit anti-gp72. Thus, OKB7, which identifies the 140Kd CR 2 molecule, also identifies a 72Kd shed fragment of CR 2 isolated from Raji cell media, which contains the C3d-binding site

  1. Environmental assessment: Davis Canyon site, Utah

    International Nuclear Information System (INIS)

    1986-05-01

    In February 1983, the US Department of Energy (DOE) identified the Davis Canyon site in Utah as one of the nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Davis Canyon site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. These evaluations were reported in draft environmental assessments (EAs), which were issued for public review and comment. After considering the comments received on the draft EAs, the DOE prepared the final EA. The Davis Canyon site is in the Paradox Basin, which is one of five distinct geohydrologic settings considered for the first repository. This setting contains one other potentially acceptable site -- the Lavender Canyon site. Although the Lavender Canyon site is suitable for site characterization, the DOE has concluded that the Davis Canyon site is the preferred site in the Paradox Basin. On the basis of the evaluations reported in this EA, the DOE has found that the Davis Canyon site is not disqualified under the guidelines. Furthermore, the DOE has fond that the site is suitable for site characterization because the evidence does not support a conclusion that the site will not be able to meet each of the qualifying conditions specified in the guidelines. On the basis of these findings, the DOE is nominating the Davis Canyon site as one of five sites suitable for characterization. 181 figs., 175 tabs

  2. Environmental assessment: Davis Canyon site, Utah

    Energy Technology Data Exchange (ETDEWEB)

    none,

    1986-05-01

    In February 1983, the US Department of Energy (DOE) identified the Davis Canyon site in Utah as one of the nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Davis Canyon site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. These evaluations were reported in draft environmental assessments (EAs), which were issued for public review and comment. After considering the comments received on the draft EAs, the DOE prepared the final EA. The Davis Canyon site is in the Paradox Basin, which is one of five distinct geohydrologic settings considered for the first repository. This setting contains one other potentially acceptable site -- the Lavender Canyon site. Although the Lavender Canyon site is suitable for site characterization, the DOE has concluded that the Davis Canyon site is the preferred site in the Paradox Basin. On the basis of the evaluations reported in this EA, the DOE has found that the Davis Canyon site is not disqualified under the guidelines. Furthermore, the DOE has fond that the site is suitable for site characterization because the evidence does not support a conclusion that the site will not be able to meet each of the qualifying conditions specified in the guidelines. On the basis of these findings, the DOE is nominating the Davis Canyon site as one of five sites suitable for characterization. 181 figs., 175 tabs.

  3. Early Site Permit Demonstration Program, plant parameters envelopes: Comparison with ranges of values for four hypothetical sites

    International Nuclear Information System (INIS)

    1992-09-01

    The purpose of this volume is to report the results of the comparison of the ALWR plan parameters envelope with values of site characteristics developed for our hypothetical sites that generally represent conditions encountered within the United States. This effort is not intended to identify or address the suitability of any existing site, site area, or region in the United States. Also included in this volume is Appendix F, SERCH Summaries Regarding Siting

  4. A 1.4-Billion Pixel Map of the Seafloor: BOEM's Mission to Visualize Dynamic Geology and Identify Natural Seep Sites in the Gulf of Mexico

    Science.gov (United States)

    Kramer, K.; Shedd, W. W.

    2017-12-01

    In May, 2017, the U.S. Department of the Interior's Bureau of Ocean Energy Management (BOEM) published a high-resolution seafloor map of the northern Gulf of Mexico region. The new map, derived from 3-D seismic surveys, provides the scientific community with enhanced resolution and reveals previously undiscovered and poorly resolved geologic features of the continental slope, salt minibasin province, abyssal plain, Mississippi Fan, and the Florida Shelf and Escarpment. It becomes an even more powerful scientific tool when paired with BOEM's public database of 35,000 seafloor features, identifying natural hydrocarbon seeps, hard grounds, mud volcanoes, sediment flows, pockmarks, slumps, and many others. BOEM has mapped the Gulf of Mexico seafloor since 1998 in a regulatory mission to identify natural oil and gas seeps and protect the coral and chemosynthetic communities growing at those sites. The nineteen-year mapping effort, still ongoing, resulted in the creation of the 1.4-billion pixel map and the seafloor features database. With these tools and continual collaboration with academia, professional scientific institutions, and the offshore energy industry, BOEM will continue to incorporate new data to update and expand these two resources on a regular basis. They can be downloaded for free from BOEM's website at https://www.boem.gov/Gulf-of-Mexico-Deepwater-Bathymetry/ and https://www.boem.gov/Seismic-Water-Bottom-Anomalies-Map-Gallery/.

  5. Identifying key controls on the behavior of an acidic-U(VI) plume in the Savannah River Site using reactive transport modeling.

    Science.gov (United States)

    Bea, Sergio A; Wainwright, Haruko; Spycher, Nicolas; Faybishenko, Boris; Hubbard, Susan S; Denham, Miles E

    2013-08-01

    Acidic low-level waste radioactive waste solutions were discharged to three unlined seepage basins at the F-Area of the Department of Energy (DOE) Savannah River Site (SRS), South Carolina, USA, from 1955 through 1989. Despite many years of active remediation, the groundwater remains acidic and contaminated with significant levels of U(VI) and other radionuclides. Monitored Natural Attenuation (MNA) is a desired closure strategy for the site, based on the premise that regional flow of clean background groundwater will eventually neutralize the groundwater acidity, immobilizing U(VI) through adsorption. An in situ treatment system is currently in place to accelerate this in the downgradient portion of the plume and similar measures could be taken upgradient if necessary. Understanding the long-term pH and U(VI) adsorption behavior at the site is critical to assess feasibility of MNA along with the in-situ remediation treatments. This paper presents a reactive transport (RT) model and uncertainty quantification (UQ) analyses to explore key controls on the U(VI)-plume evolution and long-term mobility at this site. Two-dimensional numerical RT simulations are run including the saturated and unsaturated (vadose) zones, U(VI) and H(+) adsorption (surface complexation) onto sediments, dissolution and precipitation of Al and Fe minerals, and key hydrodynamic processes are considered. UQ techniques are applied using a new open-source tool that is part of the developing ASCEM reactive transport modeling and analysis framework to: (1) identify the complex physical and geochemical processes that control the U(VI) plume migration in the pH range where the plume is highly mobile, (2) evaluate those physical and geochemical parameters that are most controlling, and (3) predict the future plume evolution constrained by historical, chemical and hydrological data. The RT simulation results show a good agreement with the observed historical pH and concentrations of U(VI), nitrates

  6. The hamster cheek pouch: an immunologically privileged site suitable to the study of granulomatous infections A bolsa jugal do hamster: um local imunologicamente privilegiado, apropriado para o estudo das ¡nfecções granulomatosas

    Directory of Open Access Journals (Sweden)

    M. S. P. de Arruda

    1995-08-01

    Full Text Available The hamster check pouch is an invagination of oral mucosa, characterized histologically as skin-like. In this paper we describe anatomical, histological and embriological features of the pouch and coment on the pouch as an immunologically privileged site since it lacks lymphatic drainage and has few Langerhans cells. We present the review from literature and our observations after inoculation in the pouch of mycobacteriae (BCG, Mycobacterium tuberculosis and Mycobacterium leprae and a fungus (Paracoccidioides brasiliensis. Lesions in the pouch were granulomatous but smaller and long lasting; even granulomatous, the reaction was inefficient to control the proliferation of agents compared with inoculation in other sites, except for BCG. Appearance of immunity was also delayed or absent and, when it was detected, a sharp decrease in number of agents in pouch lesions was observed. These observations make the pouch an interesting site for the study of the role of immune system in infeccious diseases and in granuloma formation.A bolsa jugal do hamster (BJH é uma invaginação da mucosa oral, caracterizada histologicamente como semelhante a pele. Nesse estudo nós descrevemos algumas de suas características anatômicas, histológicas e embriológicas e comentamos sobre sua propriedade como local imunologicamente privilegiado, considerando a ausência de drenagem linfática e o reduzido número de células de Langerhans. Apresentamos também os resultados obtidos quando da inoculação de micobacterias (BCG, Mycobacterium tuberculosis e Mycobacterium leprae e do fungo Paracoccidioides brasiliensis na bolsa jugal. Comparada com as lesões provocadas em outras localizações e, à exceção do BCG, as lesões induzidas na bolsa são menores e de maior duração e, mesmo quando granulomatosas, incapazes de controlar a multiplicação do agente; nos casos em que houve o desenvolvimento da resposta imune, ele se fez tardiamente e foi acompanhado pela redu

  7. Estimating Aquifer Storage and Recovery (ASR Regional and Local Suitability: A Case Study in Washington State, USA

    Directory of Open Access Journals (Sweden)

    Maria T. Gibson

    2018-01-01

    Full Text Available Developing aquifers as underground water supply reservoirs is an advantageous approach applicable to meeting water management objectives. Aquifer storage and recovery (ASR is a direct injection and subsequent withdrawal technology that is used to increase water supply storage through injection wells. Due to site-specific hydrogeological quantification and evaluation to assess ASR suitability, limited methods have been developed to identify suitability on regional scales that are also applicable at local scales. This paper presents an ASR site scoring system developed to qualitatively assess regional and local suitability of ASR using 9 scored metrics to determine total percent of ASR suitability, partitioned into hydrogeologic properties, operational considerations, and regulatory influences. The development and application of a qualitative water well suitability method was used to assess the potential groundwater response to injection, estimate suitability based on predesignated injection rates, and provide cumulative approximation of statewide and local storage prospects. The two methods allowed for rapid assessment of ASR suitability and its applicability to regional and local water management objectives at over 280 locations within 62 watersheds in Washington, USA. It was determined that over 50% of locations evaluated are suitable for ASR and statewide injection potential equaled 6400 million liters per day. The results also indicate current limitations and/or potential benefits of developing ASR systems at the local level with the intent of assisting local water managers in strategic water supply planning.

  8. Antigenic Fingerprinting following Primary RSV Infection in Young Children Identifies Novel Antigenic Sites and Reveals Unlinked Evolution of Human Antibody Repertoires to Fusion and Attachment Glycoproteins.

    Directory of Open Access Journals (Sweden)

    Sandra Fuentes

    2016-04-01

    Full Text Available Respiratory Syncytial Virus (RSV is the major cause of pneumonia among infants. Here we elucidated the antibody repertoire following primary RSV infection and traced its evolution through adolescence and adulthood. Whole genome-fragment phage display libraries (GFPDL expressing linear and conformational epitopes in the RSV fusion protein (F and attachment protein (G were used for unbiased epitope profiling of infant sera prior to and following RSV infection. F-GFPDL analyses demonstrated modest changes in the anti-F epitope repertoires post-RSV infection, while G-GFPDL analyses revealed 100-fold increase in number of bound phages. The G-reactive epitopes spanned the N- and C-terminus of the G ectodomain, along with increased reactivity to the central conserved domain (CCD. Panels of F and G antigenic sites were synthesized to evaluate sera from young children (<2 yr, adolescents (14-18 yr and adults (30-45 yr in SPR real-time kinetics assays. A steady increase in RSV-F epitope repertoires from young children to adults was observed using peptides and F proteins. Importantly, several novel epitopes were identified in pre-fusion F and an immunodominant epitope in the F-p27. In all age groups, antibody binding to pre-fusion F was 2-3 folds higher than to post-fusion form. For RSV-G, antibody responses were high following early RSV infection in children, but declined significantly in adults, using either G proteins or peptides. This study identified unlinked evolution of anti-F and anti G responses and supportive evidence for immune pressure driven evolution of RSV-G. These findings could help development of effective countermeasures including vaccines.

  9. Use of a scenario-development procedure to identify potentially disruptive scenarios, Greater Confinement Disposal facility, Area 5, Nevada Test Site

    International Nuclear Information System (INIS)

    Guzowski, R.V.; Sandia National Labs., Albuquerque, NM

    1994-01-01

    The Greater Confinement Disposal (GCD) facility includes four boreholes that contain transuranic (TRLT) waste. Presence of the TRU waste means that this facility must comply with the US Environmental Protection Agency's Environmental Radiation Protection Standards for Management and Disposal of Spent Nuclear Fuel, High-Level and Transuranic Waste-Final Rule 40 CFR Part 191. To comply with the Containment Requirements of this rule, all potentially disruptive events and processes, and by implication all potentially disruptive combinations of events and processes (scenarios), must be identified for possible inclusion in performance assessments. Screening of the FEPs identified four events for scenario development: exploratory drilling for natural resources, drilling withdrawal wells, irrigation, and subsidence. Recent environmental-isotope analyses of the vadose zone suggest that radionuclide transport from the boreholes to the water table by infiltration is not a feasible transport mechanism within the time frame of regulatory concern. For this reason, the event of drilling withdrawal wells was merged with exploratory drilling for resources. The descriptions of the remaining three events were modified slightly to aid in estimation of event probabilities and consequence analyses. The three events are: exploratory drilling for resources penetrates a TRU borehole, irrigation occurs at the Radioactive Waste Management Site (RWMS), and subsidence occurs at the RWMS. Use of a logic diagram with these three events resulted in the construction of eight scenarios, including base-case (undisturbed) conditions. Screening these scenarios at this stage of scenario development was beyond the scope of this task. Based on the implementation assumptions, this scenario-development procedure produced a comprehensive set of mutually exclusive scenarios that are reproducible and auditable for use in GCD performance assessments

  10. Can osseous landmarks in the distal medial humerus be used to identify the attachment sites of ligaments and tendons: paleopathologic-anatomic imaging study in cadavers

    Energy Technology Data Exchange (ETDEWEB)

    Buck, Florian M. [Veterans Administration Medical Center, Department of Radiology, San Diego, CA (United States); Institut fuer Diagnostische Radiologie, Uniklinik Balgrist, Zurich (Switzerland); Zoner, Cristiane S.; Cardoso, Fabiano; Gheno, Ramon; Nico, Marcelo A.C.; Trudell, Debra J.; Resnick, Donald [Veterans Administration Medical Center, Department of Radiology, San Diego, CA (United States); Randall, Tori D. [San Diego Museum of Man, Physical Anthropology, San Diego, CA (United States)

    2010-09-15

    To describe osseous landmarks that allow identification of the attachments of the ligaments and tendons in the distal medial aspect of the humerus. Reliable osseous landmarks in the distal medial aspect of the humerus were identified in 34 well-preserved specimens from a paleopathologic collection. These osseous landmarks were then sought in magnetic resonance (MR) images of ten cadaveric elbow specimens so that the ease of their visualization and optimal imaging plane could be assessed. To assign these osseous landmarks to specific attachments of the tendons and ligaments in the distal medial humerus, we cut the specimens in slices and photographed and examined them. Subsequently, the prevalence of these osseous landmarks as well as the attachment sites of the tendons and ligaments in this location was determined. We determined ten reliable osseous landmarks in the distal medial aspect of the humerus, their prevalence and ease of identification, and their relationship to the attachments of the tendons and ligaments at the medial distal humerus. It is possible to use osseous landmarks at the distal medial humerus to facilitate identification of the different attachments of tendons and ligaments when MR images of the elbow are assessed. (orig.)

  11. Site Selection for Surplus Plutonium Disposition Facilities at the Savannah River Site

    International Nuclear Information System (INIS)

    Wike, L.D.

    2000-01-01

    A site selection study was conducted to evaluate locations for the proposed Surplus Plutonium Disposition Facilities. Facilities to be located include the Mixed Oxide (MOX) Fuel Fabrication Facility, the Pit Disassembly and Conversion Facility (PDCF), and the Plutonium Immobilization Project (PIP) facility. Objectives of the study include: (1) Confirm that the Department of Energy (DOE) selected locations for the MOX and PDCF were suitable based on selected siting criteria, (2) Recommend a site in the vicinity of F Area that is suitable for the PIP, and (3) Identify alternative suitable sites for one or more of these facilities in the event that further geotechnical characterization or other considerations result in disqualification of a currently proposed site

  12. Energy infrastructure of the United States and projected siting needs: Scoping ideas, identifying issues and options. Draft report of the Department of Energy Working Group on Energy Facility Siting to the Secretary

    Energy Technology Data Exchange (ETDEWEB)

    1993-12-01

    A Department of Energy (DOE) Working Group on Energy Facility Siting, chaired by the Policy Office with membership from the major program and staff offices of the Department, reviewed data regarding energy service needs, infrastructure requirements, and constraints to siting. The Working Group found that the expeditious siting of energy facilities has important economic, energy, and environmental implications for key Administration priorities.

  13. High FDG uptake areas on pre-radiotherapy PET/CT identify preferential sites of local relapse after chemoradiotherapy for locally advanced oesophageal cancer

    Energy Technology Data Exchange (ETDEWEB)

    Calais, Jeremie; Lemarignier, Charles; Vera, Pierre [Henri Becquerel Cancer Center and Rouen University Hospital, Nuclear Medicine Department, Rouen (France); University of Rouen, QuantIF-LITIS (Equipe d' Accueil 4108-FR CNRS 3638), Faculty of Medicine, Rouen (France); Dubray, Bernard [University of Rouen, QuantIF-LITIS (Equipe d' Accueil 4108-FR CNRS 3638), Faculty of Medicine, Rouen (France); Centre Henri Becquerel and Rouen University Hospital, Department of Radiotherapy and Medical Physics, Rouen (France); Nkhali, Lamyaa; Thureau, Sebastien; Modzelewski, Romain; Gardin, Isabelle [Henri Becquerel Cancer Center and Rouen University Hospital, Nuclear Medicine Department, Rouen (France); University of Rouen, QuantIF-LITIS (Equipe d' Accueil 4108-FR CNRS 3638), Faculty of Medicine, Rouen (France); Centre Henri Becquerel and Rouen University Hospital, Department of Radiotherapy and Medical Physics, Rouen (France); Di Fiore, Frederic [Rouen University Hospital, Department of Gastroenterology, Rouen (France); Rouen University Hospital, Department of Oncology, Henri Becquerel Cancer Center, IRON, Rouen (France); Michel, Pierre [Rouen University Hospital, Department of Gastroenterology, Rouen (France)

    2015-05-01

    The high failure rates in the radiotherapy (RT) target volume suggest that patients with locally advanced oesophageal cancer (LAOC) would benefit from increased total RT doses. High 2-deoxy-2-[{sup 18}F]fluoro-D-glucose (FDG) uptake (hotspot) on pre-RT FDG positron emission tomography (PET)/CT has been reported to identify intra-tumour sites at increased risk of relapse after RT in non-small cell lung cancer and in rectal cancer. Our aim was to confirm these observations in patients with LAOC and to determine the optimal maximum standardized uptake value (SUV{sub max}) threshold to delineate smaller RT target volumes that would facilitate RT dose escalation without impaired tolerance. The study included 98 consecutive patients with LAOC treated by chemoradiotherapy (CRT). All patients underwent FDG PET/CT at initial staging and during systematic follow-up in a single institution. FDG PET/CT acquisitions were coregistered on the initial CT scan. Various subvolumes within the initial tumour (30, 40, 50, 60, 70, 80 and 90 % SUV{sub max} thresholds) and in the subsequent local recurrence (LR, 40 and 90 % SUV{sub max} thresholds) were pasted on the initial CT scan and compared[Dice, Jaccard, overlap fraction (OF), common volume/baseline volume, common volume/recurrent volume]. Thirty-five patients had LR. The initial metabolic tumour volume was significantly higher in LR tumours than in the locally controlled tumours (mean 25.4 vs 14.2 cc; p = 0.002). The subvolumes delineated on initial PET/CT with a 30-60 % SUV{sub max} threshold were in good agreement with the recurrent volume at 40 % SUV{sub max} (OF = 0.60-0.80). The subvolumes delineated on initial PET/CT with a 30-60 % SUV{sub max} threshold were in good to excellent agreement with the core volume (90 % SUV{sub max}) of the relapse (common volume/recurrent volume and OF indices 0.61-0.89). High FDG uptake on pretreatment PET/CT identifies tumour subvolumes that are at greater risk of recurrence after CRT in

  14. The Decline of Laparoendoscopic Single-Site Surgery: A Survey of the Endourological Society to Identify Shortcomings and Guidance for Future Directions.

    Science.gov (United States)

    Sorokin, Igor; Canvasser, Noah E; Irwin, Brian; Autorino, Riccardo; Liatsikos, Evangelos N; Cadeddu, Jeffrey A; Rane, Abhay

    2017-10-01

    To analyze the most recent temporal trends in the adoption of urologic laparoendoscopic single-site (LESS), to identify the perceived limitations associated with its decline, and to determine factors that might revive the role of LESS in the field of minimally invasive urologic surgery. A 15 question survey was created and sent to members of the Endourological Society in September 2016. Only members who performed LESS procedures in practice were asked to respond. In total, 106 urologists responded to the survey. Most of the respondents were from the United States (35%) and worked in an academic hospital (84.9%). Standard LESS was the most popular approach (78.1%), while 14.3% used robotics, and 7.6% used both. 2009 marked the most popular year to perform the initial (27.6%) and the majority (20%) of LESS procedures. The most common LESS procedure was a radical/simple nephrectomy (51%) followed by pyeloplasty (17.3%). In the past 12 months, 60% of respondents had performed no LESS procedures. Compared to conventional laparoscopy, respondents only believed cosmesis to be better, however, this enthusiasm waned over time. Worsening shifts in enthusiasm for LESS also occurred with patient desire, marketability, cost, safety, and robotic adaptability. The highest rated factor to help LESS regain popularity was a new robotic platform. The decline of LESS is apparent, with few urologists continuing to perform procedures attributed to multiple factors. The availability of a purpose-built robotic platform and better instrumentation might translate into a renewed future interest of LESS.

  15. Analysis of 30 putative BRCA1 splicing mutations in hereditary breast and ovarian cancer families identifies exonic splice site mutations that escape in silico prediction.

    Directory of Open Access Journals (Sweden)

    Barbara Wappenschmidt

    Full Text Available Screening for pathogenic mutations in breast and ovarian cancer genes such as BRCA1/2, CHEK2 and RAD51C is common practice for individuals from high-risk families. However, test results may be ambiguous due to the presence of unclassified variants (UCV in the concurrent absence of clearly cancer-predisposing mutations. Especially the presence of intronic or exonic variants within these genes that possibly affect proper pre-mRNA processing poses a challenge as their functional implications are not immediately apparent. Therefore, it appears necessary to characterize potential splicing UCV and to develop appropriate classification tools. We investigated 30 distinct BRCA1 variants, both intronic and exonic, regarding their spliceogenic potential by commonly used in silico prediction algorithms (HSF, MaxEntScan along with in vitro transcript analyses. A total of 25 variants were identified spliceogenic, either causing/enhancing exon skipping or activation of cryptic splice sites, or both. Except from a single intronic variant causing minor effects on BRCA1 pre-mRNA processing in our analyses, 23 out of 24 intronic variants were correctly predicted by MaxEntScan, while HSF was less accurate in this cohort. Among the 6 exonic variants analyzed, 4 severely impair correct pre-mRNA processing, while the remaining two have partial effects. In contrast to the intronic alterations investigated, only half of the spliceogenic exonic variants were correctly predicted by HSF and/or MaxEntScan. These data support the idea that exonic splicing mutations are commonly disease-causing and concurrently prone to escape in silico prediction, hence necessitating experimental in vitro splicing analysis.

  16. Post-genome wide association studies and functional analyses identify association of MPP7 gene variants with site-specific bone mineral density.

    Science.gov (United States)

    Xiao, Su-Mei; Kung, Annie Wai Chee; Gao, Yi; Lau, Kam-Shing; Ma, Alvin; Zhang, Zhen-Lin; Liu, Jian-Min; Xia, Wiebo; He, Jin-Wei; Zhao, Lin; Nie, Min; Fu, Wei-Zhen; Zhang, Min-Jia; Sun, Jing; Kwan, Johnny S H; Tso, Gloria Hoi Wan; Dai, Zhi-Jie; Cheung, Ching-Lung; Bow, Cora H; Leung, Anskar Yu Hung; Tan, Kathryn Choon Beng; Sham, Pak Chung

    2012-04-01

    Our previous genome-wide association study (GWAS) in a Hong Kong Southern Chinese population with extreme bone mineral density (BMD) scores revealed suggestive association with MPP7, which ranked second after JAG1 as a candidate gene for BMD. To follow-up this suggestive signal, we replicated the top single-nucleotide polymorphism rs4317882 of MPP7 in three additional independent Asian-descent samples (n= 2684). The association of rs4317882 reached the genome-wide significance in the meta-analysis of all available subjects (P(meta)= 4.58 × 10(-8), n= 4204). Site heterogeneity was observed, with a larger effect on spine than hip BMD. Further functional studies in a zebrafish model revealed that vertebral bone mass was lower in an mpp7 knock-down model compared with the wide-type (P= 9.64 × 10(-4), n= 21). In addition, MPP7 was found to have constitutive expression in human bone-derived cells during osteogenesis. Immunostaining of murine MC3T3-E1 cells revealed that the Mpp7 protein is localized in the plasma membrane and intracytoplasmic compartment of osteoblasts. In an assessment of the function of identified variants, an electrophoretic mobility shift assay demonstrated the binding of transcriptional factor GATA2 to the risk allele 'A' but not the 'G' allele of rs4317882. An mRNA expression study in human peripheral blood mononuclear cells confirmed that the low BMD-related allele 'A' of rs4317882 was associated with lower MPP7 expression (P= 9.07 × 10(-3), n= 135). Our data suggest a genetic and functional association of MPP7 with BMD variation.

  17. A GIS model of habitat suitability for Solanum conocarpum (Solanaceae) in St. John, US Virgin Islands

    Science.gov (United States)

    Palumbo, Matthew D.; Fleming, Jonathan P.; Monsegur, Omar A.; Vilella, Francisco

    2016-01-01

    Solanum conocarpum (Solanaceae) (Marron Bacora) is a rare, dry-forest shrub endemic to the island of St. John, US Virgin Islands, considered for listing under the Endangered Species Act. Given its status as a species of conservation concern, we incorporated environmental characteristics of 3 observed populations and 5 additional known locations into a geographic information system (GIS) analysis to create a habitat-suitability model for the species on the island of St. John. Our model identified 1929.87 ha of highly suitable and moderately suitable habitat. Of these, 1161.20 ha (60.2%) occurred within the boundaries of Virgin Islands National Park. Our model provides spatial information on potential locations for future surveys and restoration sites for this endemic species of the US Virgin Islands.

  18. Siting the superconducting super collider

    International Nuclear Information System (INIS)

    Price, R.; Rooney, R.C.

    1988-01-01

    At the request of the Department of Energy, the National Academy of Sciences and the National Academy of Engineering established the Super Collider Site Evaluation Committee to evaluate the suitability of proposed sites for the Superconducting Super Collider. Thirty-six proposals were examined by the committee. Using the set of criteria announced by DOE in its Invitation for Site Proposals, the committee identified eight sites that merited inclusion on a ''best qualified list.'' The list represents the best collective judgment of 21 individuals, carefully chosen for their expertise and impartiality, after a detailed assessment of the proposals using 19 technical subcriteria and DOE's life cycle cost estimates. The sites, in alphabetical order, are: Arizona/Maricopa; Colorado; Illinois; Michigan/Stockbridge; New York/Rochester; North Carolina; Tennessee; and Texas/Dallas-Fort Worth. The evaluation of these sites and the Superconducting Super Collider are discussed in this book

  19. Environmental assessment: Richton Dome site, Mississippi

    International Nuclear Information System (INIS)

    1986-05-01

    In February 1983, the US Department of Energy (DOE) identified the Richton Dome site in Mississippi as one of the nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Richton Dome site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. These evaluations were reported in draft environmental assessments (EAs), which were issued for public review and comment. After considering the comments received on the draft EAs, the DOE prepared the final EAs. The site is in the Gulf interior region, which is one of five distinct geohydrologic settings considered for the first repository. This setting contains two other potentially acceptable sites--the Cypress Creek Dome site in Mississippi and the Vacherie Dome site in Louisiana. Although the Cypress Creek Dome and the Vacherie Dome sites are suitable for site characterization, the DOE has concluded that the Richton Dome site is the preferred site in the Gulf interior region. On the basis of the evaluations reported in this EA, the DOE has found that the Richton Dome site is not disqualified under the guidelines

  20. Environmental assessment: Richton Dome Site, Mississippi

    Energy Technology Data Exchange (ETDEWEB)

    none,

    1986-05-01

    In February 1983, the US Department of Energy (DOE) identified the Richton Dome site in Mississippi as one of the nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Richton Dome site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. These evaluations were reported in draft environmental assessments (EAs), which were issued for public review and comment. After considering the comments received on the draft EAs, the DOE prepared the final EAs. The site is in the Gulf interior region, which is one of five distinct geohydrologic settings considered for the first repository. This setting contains two other potentially acceptable sites--the Cypress Creek Dome site in Mississippi and the Vacherie Dome site in Louisiana. Although the Cypress Creek Dome and the Vacherie Dome sites are suitable for site characterization, the DOE has concluded that the Richton Dome site is the preferred site in the Gulf interior region. On the basis of the evaluations reported in this EA, the DOE has found that the Richton Dome site is not disqualified under the guidelines.

  1. Environmental assessment: Richton Dome site, Mississippi

    Energy Technology Data Exchange (ETDEWEB)

    none,

    1986-05-01

    In February 1983, the US Department of Energy (DOE) identified the Richton Dome site in Mississippi as one of the nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Richton Dome site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. These evaluations were reported in draft environmental assessments (EAs), which were issued for public review and comment. After considering the comments received on the draft EAs, the DOE prepared the final EAs. The site is in the Gulf interior region, which is one of five distinct geohydrologic settings considered for the first repository. This setting contains two other potentially acceptable sites--the Cypress Creek Dome site in Mississippi and the Vacherie Dome site in Louisiana. Although the Cypress Creek Dome and the Vacherie Dome sites are suitable for site characterization, the DOE has concluded that the Richton Dome site is the preferred site in the Gulf interior region. On the basis of the evaluations reported in this EA, the DOE has found that the Richton Dome site is not disqualified under the guidelines.

  2. Environmental assessment: Richton Dome Site, Mississippi

    International Nuclear Information System (INIS)

    1986-05-01

    In February 1983, the US Department of Energy (DOE) identified the Richton Dome site in Mississippi as one of the nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Richton Dome site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. These evaluations were reported in draft environmental assessments (EAs), which were issued for public review and comment. After considering the comments received on the draft EAs, the DOE prepared the final EAs. The site is in the Gulf interior region, which is one of five distinct geohydrologic settings considered for the first repository. This setting contains two other potentially acceptable sites--the Cypress Creek Dome site in Mississippi and the Vacherie Dome site in Louisiana. Although the Cypress Creek Dome and the Vacherie Dome sites are suitable for site characterization, the DOE has concluded that the Richton Dome site is the preferred site in the Gulf interior region. On the basis of the evaluations reported in this EA, the DOE has found that the Richton Dome site is not disqualified under the guidelines

  3. Readability, complexity, and suitability of online resources for mastectomy and lumpectomy.

    Science.gov (United States)

    Tran, Bao Ngoc N; Singh, Mansher; Singhal, Dhruv; Rudd, Rima; Lee, Bernard T

    2017-05-15

    Nearly half of American adults have low or marginal health literacy. This negatively affects patients' participation, decision-making, satisfaction, and overall outcomes especially when there is a mismatch between information provided and the skills of the intended audience. Recommendations that patient information be written below the sixth grade level have been made for over three decades. This study compares online resources for mastectomy versus lumpectomy using expanded metrics including readability level, complexity, and density of data and overall suitability for public consumption. The 10 highest ranked Web sites for mastectomy and lumpectomy were identified using the largest Internet engine (Google). Each Web site was assessed for readability (Simple Measure of Gobbledygook), complexity (PMOSE/iKIRSCH), and suitability (Suitability Assessment of Materials). Scores were analyzed by each Web site and overall. Readability analysis showed a significant reading grade level difference between mastectomy and lumpectomy online information (15.4 and 13.9, P = 0.04, respectively). Complexity analysis via PMOSE/iKIRSCH revealed a mean score of 6.5 for mastectomy materials corresponding to "low" complexity and eighth to 12 th grade education. Lumpectomy literature had a lower PMOSE/iKIRSCH score of 5.8 corresponding to a "very low" complexity and fourth to eighth grade education (P = 0.05). Suitability assessment showed mean values of 41% and 46% (P = 0.83) labeled as the lowest level of "adequacy" for mastectomy and lumpectomy materials, respectively. Inter-rater reliability was high for both complexity and suitability analysis. Online resources for the surgical treatment of breast cancer are above the recommended reading grade level. The suitability level is barely adequate indicating a need for revision. Online resources for mastectomy have a higher reading grade level than do materials for lumpectomy and tend to be more complex. Copyright © 2017 Elsevier

  4. GIS-based rapid-assessment of bighead carp Hypophthalmichthys nobilis (Richardson, 1845) suitability in reservoirs

    Science.gov (United States)

    Long, James M.; Liang, Yu; Shoup, Daniel E.; Dzialowski, Andrew R.; Bidwell, Joseph R.

    2014-01-01

    Broad-scale niche models are good for examining the potential for invasive species occurrences, but can fall short in providing managers with site-specific locations for monitoring. Using Oklahoma as an example, where invasive bighead carp (Hypophthalmichthys nobilis) are established in certain reservoirs, but predicted to be widely distributed based on broad-scale niche models, we cast bighead carp reproductive ecology in a site-specific geospatial framework to determine their potential establishment in additional reservoirs. Because bighead carp require large, long free-flowing rivers with suitable hydrology for reproduction but can persist in reservoirs, we considered reservoir tributaries with mean annual daily discharge ≥8.5 cubic meters per second (m3 /s) and quantified the length of their unimpeded portions. In contrast to published broad-scale niche models that identified nearly the entire state as susceptible to invasion, our site-specific models showed that few reservoirs in Oklahoma (N = 9) were suitable for bighead carp establishment. Moreover, this method was rapid and identified sites that could be prioritized for increased study or scrutiny. Our results highlight the importance of considering the environmental characteristics of individual sites, which is often the level at which management efforts are implemented when assessing susceptibility to invasion.

  5. Environmental assessment overview, Reference repository location, Hanford site, Washington

    International Nuclear Information System (INIS)

    1986-05-01

    In February 1983, the US Department of Energy (DOE) identified a reference repository location at the Hanford Site in Washington as one of the nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. The site is in the Columbia Plateau, which is one of five distinct geohydrologic settings considered for the first repository. To determine their suitability, the Hanford site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. On the basis of the evaluations reported in this EA, the DOE has found that the Hanford site is not disqualified under the guidelines. On the basis of these findings, the DOE is nominating the Hanford site as one of five sites suitable for characterization. 3 figs

  6. Past climate reconstruction: a tool for assessing site suitability

    International Nuclear Information System (INIS)

    Potter, G.

    1978-01-01

    Reconstructing past climatic variations can lead to a better understanding of possible future precipitation and groundwater recharge patterns. Work so far has led to several new insights into past climate variability and will provide input into the hydrologic modeling effort in progress for the Waste Management Program. Short-term reconstructions (0 to 350 y) suggest that the basin and range of the southwestern United States have the driest, least variable precipitation record. The Pacific Northwest shows higher variability and several trends lasting for more then 25 y. The Southern High Plains have even more variability, but the upper Midwest and Southwest vary most and have the highest precipitation amounts. Pollen and lake level data from the literature suggest that the Southwest was wetter during at least part of the last glacial maximum than it is today

  7. Identification of Suitable Indices for Identification of Potential Sites ...

    African Journals Online (AJOL)

    system (GIS)-based decision support system (DSS) can be a valuable tool for such a task. However, key to .... The data were processed in a GIS ..... Landslide susceptibility mapping by GIS-based ... remote sensing and GIS in the Makanya.

  8. Field site selection: getting it right first time around

    NARCIS (Netherlands)

    Malcolm, Colin A.; El Sayed, Badria; Babiker, Ahmed; Girod, Romain; Fontenille, Didier; Knols, Bart G. J.; Nugud, Abdel Hameed; Benedict, Mark Q.

    2009-01-01

    The selection of suitable field sites for integrated control of Anopheles mosquitoes using the sterile insect technique (SIT) requires consideration of the full gamut of factors facing most proposed control strategies, but four criteria identify an ideal site: 1) a single malaria vector, 2) an

  9. The disposal of Canada's nuclear fuel waste: site screening and site evaluation technology

    International Nuclear Information System (INIS)

    Davison, C.C.; Brown, A.; Everitt, R.A.; Gascoyne, M.; Kozak, E.T.; Lodha, G.S.; Martin, C.D.; Soonawala, N.M.; Stevenson, D.R.; Thorne, G.A.; Whitaker, S.H.

    1994-06-01

    The concept for the disposal of Canada's nuclear fuel waste is to dispose of the waste in an underground vault, nominally at 500 m to 1000 m depth, at a suitable site in plutonic rock of the Canadian Shield. The feasibility of this concept and assessments of its impact on the environment and human health, will be documented by AECL in an Environmental Impact Statement (EIS). This report is one of nine primary references for the EIS. It describes the approach and methods that would be used during the siting stage of the disposal project to identify a preferred candidate disposal site and to confirm its suitability for constructing a disposal facility. The siting stage is divided into two distinct but closely related substages, site screening and site evaluation. Site screening would mainly involve reconnaissance investigations of siting regions of the Shield to identify potential candidate areas where suitable vault locations are likely to exist. Site screening would identify a small number of candidate areas where further detailed investigations were warranted. Site evaluation would involve progressively more detailed surface and subsurface investigations of the candidate areas to first identify potentially suitable vault locations within the candidate areas, and then characterize these potential disposal sites to identify the preferred candidate location for constructing the disposal vault. Site evaluation would conclude with the construction of exploratory shafts and tunnels at the preferred vault location, and underground characterization would be done to confirm the suitability of the preferred candidate site. An integrated program of geological, geophysical, hydrogeological, geochemical and geomechanical investigations would be implemented to obtain the geoscience information needed to assess the suitability of the candidate siting areas and candidate sites for locating a disposal vault. The candidate siting areas and candidate disposal vault sites would be

  10. Implications of the timing of the preliminary determination of suitability

    International Nuclear Information System (INIS)

    Cotton, T.A.

    1986-01-01

    The Nuclear Waste Policy Act of 1982 requires that the Enviromental Impact Statement prepared for the recommendation of a repository site must consider three sites -- the one selected for the repository and at least two alternatives. All of these sites must have been characterized, and the Secretary of Energy must have made a preliminary determination that each is suitable for development as a repository. There is great disagreement about whether that ''preliminary determination of suitability'' is to be made before or after site characterization. If the Act is interpreted as requiring the determination to be made after characterization is completed, DOE cannot recommend the first site for licensing until it has three sites that appear suitable after full characterization; if the determination can be made before characterization, DOE can proceed to licensing even if only one site survives characterization. While DOE plans to make the preliminary determination before starting characterization, the uncertainty about how a court might ultimately interpret the Act injects a significant institutional uncertainty into the schedule for the repository, and complicates contingency planning for the siting process. Early resolution of the interpretation would greatly aid DOE's planning for the siting program

  11. Site locality identification study: Hanford Site. Volume I. Methodology, guidelines, and screening

    International Nuclear Information System (INIS)

    1980-07-01

    Presented in this report are the results of the site locality identification study for the Hanford Site using a screening process. To enable evaluation of the entire Hanford Site, the screening process was applied to a somewhat larger area; i.e., the Pasco Basin. The study consisted of a series of screening steps that progressively focused on smaller areas which are within the Hanford Site and which had a higher potential for containing suitable repository sites for nuclear waste than the areas not included for further study. Five site localities, designated H-1, H-2, H-3, H-4, H-5 (Figure A), varying in size from approximately 10 to 50 square miles, were identified on the Hanford Site. It is anticipated that each site locality may contain one or more candidate sites suitable for a nuclear waste repository. The site locality identification study began with definition of objectives and the development of guidelines for screening. Three objectives were defined: (1) maximize public health and safety; (2) minimize adverse environmental and socioeconomic impacts; and (3) minimize system costs. The screening guidelines have numerical values that provided the basis for the successive reduction of the area under study and to focus on smaller areas that had a higher likelihood of containing suitable sites

  12. Comparative assessment of environmental and socio-economic impacts of disposal of radioactive waste by shallow burial at sites identified by Nirex

    International Nuclear Information System (INIS)

    Gordon, A.E.M.; Morrow, A.J.; Watson, S.R.

    1987-09-01

    This case study tested two methodologies, comparative assessment and multi-attribute value analysis, on repository site selection. Problems affecting their application stemmed from incomplete baseline and proposed project data and from the impacts being essentially indistinguishable between sites. The latter meant that initial screening was not possible and subsequent screening became arbitrary. The large number of impacts which had to be retained made handling difficult and meaningful rating under comparative assessment was virtually impossible without introducing implicit weightings and adjusting the scale. Multi-attribute value analysis, whilst the more data demanding of the two methodologies, has a greater capability for handling the impacts. Clearly, the limitations on what data can realistically be collected must be taken into account when the evaluation methodology is designed. Ideally a draft methodology should be applied to one site and modified as need be before used for the formal assessment. (author)

  13. Environmental assessment overview, Deaf Smith County site, Texas

    International Nuclear Information System (INIS)

    1986-05-01

    In February 1983, the US Department of Energy (DOE) identified a location in Deaf Smith County, Texas, as one of nine potentially acceptable sites for mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Deaf Smith County site and eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. The Deaf Smith County site is in the Permian Basin, which is one of five distinct geohydrologic settings considered for the first repository. On the basis of the evaluations reported in this EA, the DOE has found that the Deaf Smith County site is not disqualified under the guidelines. On the basis of these findings, the DOE is nominating the Deaf Smith County site as one of five sites suitable for characterization. 3 figs

  14. Radioactive waste repository site selection in the Republic of Slovenia

    International Nuclear Information System (INIS)

    Jeran, M.

    1992-01-01

    The report shows the procedure for the low and intermediate level radwaste (LLW and ILW) repository site selection and the work performed up to the present. The procedure for the repository site selection is divided into four steps. In the first step the unsuitable areas are excluded by taking into consideration the rough exclusion criteria. In the second step, the remaining suitable areas are screened to identify the potential sites with respect to preference criteria. In the third step three to five candidate sites will be assessed and selected among the potential sites. In the final, the fourth step, detailed site investigation and confirmation of one or two most suitable sites will follow. In Slovenia the 1st and the 2nd step of site selection have been completed, while step 3 is now in its final stage. (author) [sl

  15. Assessment of Climate Suitability of Maize in South Korea

    Science.gov (United States)

    Hyun, S.; Choi, D.; Seo, B.

    2017-12-01

    Assessing suitable areas for crops would be useful to design alternate cropping systems as an adaptation option to climate change adaptation. Although suitable areas could be identified by using a crop growth model, it would require a number of input parameters including cultivar and soil. Instead, a simple climate suitability model, e.g., EcoCrop model, could be used for an assessment of climate suitability for a major grain crop. The objective of this study was to assess of climate suitability for maize using the EcoCrop model under climate change conditions in Korea. A long term climate data from 2000 - 2100 were compiled from weather data source. The EcoCrop model implemented in R was used to determine climate suitability index at each grid cell. Overall, the EcoCrop model tended to identify suitable areas for maize production near the coastal areas whereas the actual major production areas located in inland areas. It is likely that the discrepancy between assessed and actual crop production areas would result from the socioeconomic aspects of maize production. Because the price of maize is considerably low, maize has been grown in an area where moisture and temperature conditions would be less than optimum. In part, a simple algorithm to predict climate suitability for maize would caused a relatively large error in climate suitability assessment under the present climate conditions. In 2050s, the climate suitability for maize increased in a large areas in southern and western part of Korea. In particular, the plain areas near the coastal region had considerably greater suitability index in the future compared with mountainous areas. The expansion of suitable areas for maize would help crop production policy making such as the allocation of rice production area for other crops due to considerably less demand for the rice in Korea.

  16. Land suitability for waste disposal in metropolitan areas.

    Science.gov (United States)

    Baiocchi, Valerio; Lelo, Keti; Polettini, Alessandra; Pomi, Raffaella

    2014-08-01

    Site selection for waste disposal is a complex task that should meet the requirements of communities and stakeholders. In this article, three decision support methods (Boolean logic, index overlay and fuzzy gamma) are used to perform land suitability analysis for landfill siting. The study was carried out in one of the biggest metropolitan regions of Italy, with the objective of locating suitable areas for waste disposal. Physical and socio-economic information criteria for site selection were decided by a multidisciplinary group of experts, according to state-of-the-art guidelines, national legislation and local normative on waste management. The geographic information systems (GIS) based models used in this study are easy to apply but require adequate selection of criteria and weights and a careful evaluation of the results. The methodology is arranged in three steps, reflecting the criteria defined by national legislation on waste management: definition of factors that exclude location of landfills or waste treatment plants; classification of the remaining areas in terms of suitability for landfilling; and evaluation of suitable sites in relation to preferential siting factors (such as the presence of quarries or dismissed plants). The results showed that more than 80% of the provincial territory falls within constraint areas and the remaining territory is suitable for waste disposal for 0.72% or 1.93%, according to the model. The larger and most suitable sites are located in peripheral areas of the metropolitan system. The proposed approach represents a low-cost and expeditious alternative to support the spatial decision-making process. © The Author(s) 2014.

  17. A Restoration Suitability Index Model for the Eastern Oyster (Crassostrea virginica) in the Mission-Aransas Estuary, TX, USA

    Science.gov (United States)

    Beseres Pollack, Jennifer; Cleveland, Andrew; Palmer, Terence A.; Reisinger, Anthony S.; Montagna, Paul A.

    2012-01-01

    Oyster reefs are one of the most threatened marine habitats on earth, with habitat loss resulting from water quality degradation, coastal development, destructive fishing practices, overfishing, and storm impacts. For successful and sustainable oyster reef restoration efforts, it is necessary to choose sites that support long-term growth and survival of oysters. Selection of suitable sites is critically important as it can greatly influence mortality factors and may largely determine the ultimate success of the restoration project. The application of Geographic Information Systems (GIS) provides an effective methodology for identifying suitable sites for oyster reef restoration and removes much of the uncertainty involved in the sometimes trial and error selection process. This approach also provides an objective and quantitative tool for planning future oyster reef restoration efforts. The aim of this study was to develop a restoration suitability index model and reef quality index model to characterize locations based on their potential for successful reef restoration within the Mission-Aransas Estuary, Texas, USA. The restoration suitability index model focuses on salinity, temperature, turbidity, dissolved oxygen, and depth, while the reef quality index model focuses on abundance of live oysters, dead shell, and spat. Size-specific Perkinsus marinus infection levels were mapped to illustrate general disease trends. This application was effective in identifying suitable sites for oyster reef restoration, is flexible in its use, and provides a mechanism for considering alternative approaches. The end product is a practical decision-support tool that can be used by coastal resource managers to improve oyster restoration efforts. As oyster reef restoration activities continue at small and large-scales, site selection criteria are critical for assisting stakeholders and managers and for maximizing long-term sustainability of oyster resources. PMID:22792410

  18. A fuzzy approach to a multiple criteria and geographical information system for decision support on suitable locations for biogas plants

    DEFF Research Database (Denmark)

    Franco de los Rios, Camilo Andres; Bojesen, Mikkel; Hougaard, Jens Leth

    The purpose of this paper is to model the multi-criteria decision problem of identifying the most suitable facility locations for biogas plants under an integrated decision support methodology. Here the Geographical Information System (GIS) is used for measuring the attributes of the alternatives...... according to a given set of criteria. Measurements are taken in interval form, expressing the natural imprecision of common data, and the Fuzzy Weighted Overlap Dominance (FWOD) procedure is applied for aggregating and exploiting this kind of data, obtaining suitability degrees for every alternative....... The estimation of criteria weights, which is necessary for applying the FWOD procedure, is done by means of the Analytical Hierarchy Process (AHP), such that a combined AHP-FWOD methodology allows identifying the more suitable sites for building biogas plants. We show that the FWOD relevance-ranking procedure...

  19. TargetM6A: Identifying N6-Methyladenosine Sites From RNA Sequences via Position-Specific Nucleotide Propensities and a Support Vector Machine.

    Science.gov (United States)

    Li, Guang-Qing; Liu, Zi; Shen, Hong-Bin; Yu, Dong-Jun

    2016-10-01

    As one of the most ubiquitous post-transcriptional modifications of RNA, N 6 -methyladenosine ( [Formula: see text]) plays an essential role in many vital biological processes. The identification of [Formula: see text] sites in RNAs is significantly important for both basic biomedical research and practical drug development. In this study, we designed a computational-based method, called TargetM6A, to rapidly and accurately target [Formula: see text] sites solely from the primary RNA sequences. Two new features, i.e., position-specific nucleotide/dinucleotide propensities (PSNP/PSDP), are introduced and combined with the traditional nucleotide composition (NC) feature to formulate RNA sequences. The extracted features are further optimized to obtain a much more compact and discriminative feature subset by applying an incremental feature selection (IFS) procedure. Based on the optimized feature subset, we trained TargetM6A on the training dataset with a support vector machine (SVM) as the prediction engine. We compared the proposed TargetM6A method with existing methods for predicting [Formula: see text] sites by performing stringent jackknife tests and independent validation tests on benchmark datasets. The experimental results show that the proposed TargetM6A method outperformed the existing methods for predicting [Formula: see text] sites and remarkably improved the prediction performances, with MCC = 0.526 and AUC = 0.818. We also provided a user-friendly web server for TargetM6A, which is publicly accessible for academic use at http://csbio.njust.edu.cn/bioinf/TargetM6A.

  20. Hydrous ferric oxide: evaluation of Cd-HFO surface complexation models combining Cd(K) EXAFS data, potentiometric titration results, and surface site structures identified from mineralogical knowledge.

    Science.gov (United States)

    Spadini, Lorenzo; Schindler, Paul W; Charlet, Laurent; Manceau, Alain; Vala Ragnarsdottir, K

    2003-10-01

    The surface properties of ferrihydrite were studied by combining wet chemical data, Cd(K) EXAFS data, and a surface structure and protonation model of the ferrihydrite surface. Acid-base titration experiments and Cd(II)-ferrihydrite sorption experiments were performed within 3titration data could be adequately modeled by triple bond Fe- OH(2)(+1/2)-H(+)triple bond Fe-OH(-1/2),logk((int))=-8.29, assuming the existence of a unique intrinsic microscopic constant, logk((int)), and consequently the existence of a single significant type of acid-base reactive functional groups. The surface structure model indicates that these groups are terminal water groups. The Cd(II) data were modeled assuming the existence of a single reactive site. The model fits the data set at low Cd(II) concentration and up to 50% surface coverage. At high coverage more Cd(II) ions than predicted are adsorbed, which is indicative of the existence of a second type of site of lower affinity. This agrees with the surface structure and protonation model developed, which indicates comparable concentrations of high- and low-affinity sites. The model further shows that for each class of low- and high-affinity sites there exists a variety of corresponding Cd surface complex structure, depending on the model crystal faces on which the complexes develop. Generally, high-affinity surface structures have surface coordinations of 3 and 4, as compared to 1 and 2 for low-affinity surface structures.

  1. Site characterization plan: Public Handbook, Yucca Mountain, Nevada

    International Nuclear Information System (INIS)

    1989-01-01

    The Yucca Mountain site in Nevada has been designated by the Nuclear Waste Policy Act of 1982, as amended, for detailed study as the candidate site for the first US geologic repository for spent nuclear fuel and high-level radioactive waste. The detailed study --- called ''site characterization'' --- will be conducted by the Department of Energy (DOE) to determine the suitability of the site for a repository and, if the site is suitable, to obtain from the Nuclear Regulatory Commission authorization to construct the repository. As part of the site characterization study, DOE has prepared a Site Characterization Plan (SCP) for the Yucca Mountain site. The Site Characterization Plan is a nine-volume document, approximately 6300 pages in length, which describes the activities that will be conducted to characterize the geologic, hydrologic, and other conditions relevant to the suitability of the site for a repository. Part 1 of this Handbook explains what site characterization is and how the Site Characterization Plan (Plan) relates to it. Part 2 tells how to locate subjects covered in the Plan. Another major purpose of this Handbook is to identify opportunities for public involement in the review of the Site Characterization Plan. DOE wants to be sure that the public has adequate opportunities to learn about the Plan and review the results of the subsequent technical studies. 14 refs

  2. Identifying criteria and establishing parameters for forest-based ecotourism in Northern Ontario, Canada

    Science.gov (United States)

    Stephen W. Boyd; Richard W. Butler; Wolfgang Haider

    1995-01-01

    This paper identifies the following criteria as indicators for ecotourism suitability within a Northern Ontario context: naturalness, wildlife, cultural heritage, landscape and community. A methodology is proposed which uses Geographical Information Systems (GIS) to identify ecotourism sites by linking criteria deemed important with actual landscape characteristics of...

  3. Evaluation of didactic suitability indicators from curricular orientations

    Directory of Open Access Journals (Sweden)

    Pedro Arteaga

    2012-12-01

    Full Text Available Assessment of didactic suitability of mathematics teaching and learning processes requires suitable instruments to guide and support it. This paper presents a methodology for progressive improvement of such instruments to evaluate the suitability of mathematical instruction processes based on the analysis of curricular orientations. Analysis units are classifi ed according to the facets and components proposed by the Didactic Suitability Theory to identify norms and suitability indicators,which are compared with the system proposed by this theory, in order to point out agreements and complementarities. This methodology is exemplified through its application to the principles and standards of the National Council of Teachers of Mathematics (NCTM in the statistics content area at the level K-8.

  4. Evaluating timber harvesting impacts on wildlife habitat suitability using FOREX

    Science.gov (United States)

    Chris B. LeDoux

    1997-01-01

    Precommercial, commercial, and final harvesting operations can impact wildlife habitat suitability by altering the vegetation composition on a given site. Harvesting operations remove trees and many times provide the necessary perturbation to trigger successional conditions different from those that existed prior to the harvest. Although these new successional changes...

  5. A passive radon dosemeter suitable for workplaces

    International Nuclear Information System (INIS)

    Orlando, C.; Orlando, P.; Patrizii, L.; Tommasino, L.; Tonnarini, S.; Trevisi, R.; Viola, P.

    2002-01-01

    The results obtained in different international intercomparisons on passive radon monitors have been analysed with the aim of identifying a suitable radon monitoring device for workplaces. From this analysis, the passive radon device, first developed for personal dosimetry in mines by the National Radiation Protection Board, UK (NRPB), has shown the most suitable set of characteristics. This radon monitor consists of a diffusion chamber, made of conductive plastic with less than 2 cm height, containing a CR-39 film (Columbia Resin 1939), as track detector. Radon detectors in workplaces may be exposed only during the working hours, thus requiring the storage of the detectors in low-radon zones when not exposed. This paper describes how this problem can be solved. Since track detectors are also efficient neutron dosemeters, care should be taken when radon monitors are used in workplaces, where they may be exposed to neutrons, such as on high altitude mountains, in the surroundings of high energy X ray facilities (where neutrons are produced by (gamma, n) reactions) or around high energy particle accelerators. To this end, the response of these passive radon monitors to high energy neutron fields has been investigated. (author)

  6. Mutational analysis of the EMCV 2A protein identifies a nuclear localization signal and an eIF4E binding site

    International Nuclear Information System (INIS)

    Groppo, Rachel; Brown, Bradley A.; Palmenberg, Ann C.

    2011-01-01

    Cardioviruses have a unique 2A protein (143 aa). During genome translation, the encephalomyocarditis virus (EMCV) 2A is released through a ribosome skipping event mitigated through C-terminal 2A sequences and by subsequent N-terminal reaction with viral 3C pro . Although viral replication is cytoplasmic, mature 2A accumulates in nucleoli shortly after infection. Some protein also transiently associates with cytoplasmic 40S ribosomal subunits, an activity contributing to inhibition of cellular cap-dependent translation. Cardiovirus sequences predict an eIF4E binding site (aa 126-134) and a nuclear localization signal (NLS, aa 91-102), within 2A, both of which are functional during EMCV infection. Point mutations preventing eIF4E:2A interactions gave small-plaque phenotype viruses, but still inhibited cellular cap-dependent translation. Deletions within the NLS motif relocalized 2A to the cytoplasm and abrogated the inhibition of cap-dependent translation. A fusion protein linking the 2A NLS to eGFP was sufficient to redirect the reporter to the nucleus but not into nucleoli.

  7. Sieve analysis of breakthrough HIV-1 sequences in HVTN 505 identifies vaccine pressure targeting the CD4 binding site of Env-gp120.

    Science.gov (United States)

    deCamp, Allan C; Rolland, Morgane; Edlefsen, Paul T; Sanders-Buell, Eric; Hall, Breana; Magaret, Craig A; Fiore-Gartland, Andrew J; Juraska, Michal; Carpp, Lindsay N; Karuna, Shelly T; Bose, Meera; LePore, Steven; Miller, Shana; O'Sullivan, Annemarie; Poltavee, Kultida; Bai, Hongjun; Dommaraju, Kalpana; Zhao, Hong; Wong, Kim; Chen, Lennie; Ahmed, Hasan; Goodman, Derrick; Tay, Matthew Z; Gottardo, Raphael; Koup, Richard A; Bailer, Robert; Mascola, John R; Graham, Barney S; Roederer, Mario; O'Connell, Robert J; Michael, Nelson L; Robb, Merlin L; Adams, Elizabeth; D'Souza, Patricia; Kublin, James; Corey, Lawrence; Geraghty, Daniel E; Frahm, Nicole; Tomaras, Georgia D; McElrath, M Juliana; Frenkel, Lisa; Styrchak, Sheila; Tovanabutra, Sodsai; Sobieszczyk, Magdalena E; Hammer, Scott M; Kim, Jerome H; Mullins, James I; Gilbert, Peter B

    2017-01-01

    Although the HVTN 505 DNA/recombinant adenovirus type 5 vector HIV-1 vaccine trial showed no overall efficacy, analysis of breakthrough HIV-1 sequences in participants can help determine whether vaccine-induced immune responses impacted viruses that caused infection. We analyzed 480 HIV-1 genomes sampled from 27 vaccine and 20 placebo recipients and found that intra-host HIV-1 diversity was significantly lower in vaccine recipients (P ≤ 0.04, Q-values ≤ 0.09) in Gag, Pol, Vif and envelope glycoprotein gp120 (Env-gp120). Furthermore, Env-gp120 sequences from vaccine recipients were significantly more distant from the subtype B vaccine insert than sequences from placebo recipients (P = 0.01, Q-value = 0.12). These vaccine effects were associated with signatures mapping to CD4 binding site and CD4-induced monoclonal antibody footprints. These results suggest either (i) no vaccine efficacy to block acquisition of any viral genotype but vaccine-accelerated Env evolution post-acquisition; or (ii) vaccine efficacy against HIV-1s with Env sequences closest to the vaccine insert combined with increased acquisition due to other factors, potentially including the vaccine vector.

  8. Glass compositions suitable for PFR wastes

    International Nuclear Information System (INIS)

    Boult, K.A.; Dalton, J.T.; Eccles, E.W.; Hough, A.; Marples, J.A.C.; Paige, E.L.; Sutcliffe, P.W.

    1988-03-01

    Previous work had identified glass compositions that were suitable for vitrifying current and future high level wastes from the Prototype Fast Reactor (PFR) fuel reprocessing plant. Further work on these glasses has shown that: a) Foaming and crystallisation can occur under certain conditions, both probably associated with the presence of iron in the waste. Either of these could lead to greater difficulties in processing. b) Inconel 690, the preferred JCM (Joule-heated Ceramic Melter) electrode material has an acceptable corrosion rate at 1200 0 C: ca 0.6mm.y -1 . c) The leach rates are unaffected by radiation damage. The density of the glass decreases slightly with α-dose, with a dependency that extrapolates, at infinite time, to an 0.13% linear expansion. d) The concentrations of the radiologically important elements Tc, Np, Pu and Am, observed in a 'repository simulation' leach test, were satisfactorily low. (author)

  9. Draft environmental assessment: Richton Dome site, Mississippi. Nuclear Waste Policy Act (Section 112)

    International Nuclear Information System (INIS)

    1984-12-01

    In February 1983, the US Department of Energy identified the Richton dome site as one of the nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Richton dome site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for Nuclear Waste Repositories. These evaluations are reported in this draft (EA), which is being issued for public review and comment. The DOE findings and determinations that are based on these evaluations are preliminary and subject to public review and comment. A final EA will be prepared after considering the comments received. On the basis of the evaluations reported in this draft EA, the DOE has found that the Richton dome site is not disqualified under the guidelines. The site is in the Gulf Interior Region of the Gulf Coastal Plain. This setting contains two other potentially acceptable sites - the Cypress Creek dome site and the Vacherie dome site. Although these other two sites appear to be suitable for site characterization, the DOE has concluded that the Richton dome site is the preferred site in the Gulf Interior Region. Furthermore, the DOE finds that the site is suitable for site characterization because the evidence does not support a conclusion that the site will not be able to meet each of the qualifying conditions specified in the guidelines. On the basis of these findings, the DOE is proposing to nominate the Richton dome site as one of five sites suitable for characterization. Having compared the Richton dome site with the other four sites proposed for nomination, the DOE has determined that the Richton dome site is not one of the three preferred sites for recommendation to the President as candidates for characterization

  10. Draft environmental assessment: Cypress Creek Dome site, Mississippi. Nuclear Waste Policy Act (Section 112)

    International Nuclear Information System (INIS)

    1984-12-01

    In February 1983, the US Department of Energy (DOE) identified the Cypress Creek dome site in Mississippi as one of nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Cypress Creek dome site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for Nuclear Waste Repositories. These evaluations are reported in this draft environmental assessment (EA), which is being issued for public review and comment. The DOE findings and determinations that are based on these evaluations are preliminary and subject to public review and comment. A final EA will be prepared after considering the comments received. On the basis of the evaluations contained in this draft EA, the DOE has found that the Cypress Creek dome site is not disqualified under the guidelines. The site is contained in the Gulf Interior Region of the Gulf Coastal Plain, which is one of five distinct geohydrologic settings considered for the first repository. This setting contains two other potentially acceptable sites - the Richton dome site and the Vacherie dome site. Although the Cypress Creek dome site appears to be suitable for site characterization, the DOE has concluded that the Richton dome site is the preferred site in the Gulf Interior Region and is proposing to nominate the Richton dome site rather than the Cypress Creek dome site as one of the three sites suitable for characterization

  11. Bitopic Ligands and Metastable Binding Sites

    DEFF Research Database (Denmark)

    Fronik, Philipp; Gaiser, Birgit I; Sejer Pedersen, Daniel

    2017-01-01

    of orthosteric binding sites. Bitopic ligands have been employed to address the selectivity problem by combining (linking) an orthosteric ligand with an allosteric modulator, theoretically leading to high-affinity subtype selective ligands. However, it remains a challenge to identify suitable allosteric binding...... that have been reported to date, this type of bitopic ligands would be composed of two identical pharmacophores. Herein, we outline the concept of bitopic ligands, review metastable binding sites, and discuss their potential as a new source of allosteric binding sites....

  12. 45 CFR 12a.4 - Suitability determination.

    Science.gov (United States)

    2010-10-01

    ... underutilized will be reviewed for suitability no earlier than six months prior to the expected date when the... following: (1) The suitability determination for a particular piece of property, and the reasons for that...

  13. Suitability Analysis and Projected Climate Change Impact on Banana and Coffee Production Zones in Nepal

    Science.gov (United States)

    Sujakhu, Nani M.; Merz, Juerg; Kindt, Roeland; Xu, Jianchu; Matin, Mir A.; Ali, Mostafa; Zomer, Robert J.

    2016-01-01

    The Government of Nepal has identified opportunities in agricultural commercialization, responding to a growing internal demand and expansion of export markets to reduce the immense trade deficit. Several cash crops, including coffee and bananas, have been identified in the recently approved Agriculture Development Strategy. Both of these crops have encouraged smallholder farmers to convert their subsistence farming practices to more commercial cultivation. Identification of suitable agro-ecological zones and understanding climate-related issues are important for improved production and livelihoods of smallholder farmers. Here, the suitability of coffee and banana crops is analyzed for different agro-ecological zones represented by Global Environmental Stratification (GEnS). Future shifts in these suitability zones are also predicted. Plantation sites in Nepal were geo-referenced and used as input in species distribution modelling. The multi-model ensemble model suggests that climate change will reduce the suitable growing area for coffee by about 72% across the selected emission scenarios from now to 2050. Impacts are low for banana growing, with a reduction in suitability by about 16% by 2050. Bananas show a lot of potential for playing an important role in Nepal as a sustainable crop in the context of climate change, as this study indicates that the amount of area suited to banana growing will grow by 40% by 2050. Based on our analysis we recommend possible new locations for coffee plantations and one method for mitigating climate change-related problems on existing plantations. These findings are expected to support planning and policy dialogue for mitigation and support better informed and scientifically based decision-making relating to these two crops. PMID:27689354

  14. [Climatic suitability of citrus in subtropical China].

    Science.gov (United States)

    Duan, Hai-Lai; Qian, Huai-Sui; Li, Ming-Xia; Du, Yao-Dong

    2010-08-01

    By applying the theories of ecological suitability and the methods of fuzzy mathematics, this paper established a climatic suitability model for citrus, calculated and evaluated the climatic suitability and its spatiotemporal differences for citrus production in subtropical China, and analyzed the climatic suitability of citrus at its different growth stages and the mean climatic suitability of citrus in different regions of subtropical China. The results showed that the citrus in subtropical China had a lower climatic suitability and a higher risk at its flower bud differentiation stage, budding stage, and fruit maturity stage, but a higher climatic suitability and a lower risk at other growth stages. Cold damage and summer drought were the key issues affecting the citrus production in subtropical China. The citrus temperature suitability represented a latitudinal zonal pattern, i. e., decreased with increasing latitude; its precipitation suitability was high in the line of "Sheyang-Napo", medium in the southeast of the line, low in the northwest of the line, and non in high mountainous area; while the sunlight suitability was in line with the actual duration of sunshine, namely, higher in high-latitude areas than in low-latitude areas, and higher in high-altitude areas than in plain areas. Limited by temperature factor, the climatic suitability was in accordance with temperature suitability, i. e., south parts had a higher suitability than north parts, basically representing latitudinal zonal pattern. From the analysis of the inter-annual changes of citrus climatic suitability, it could be seen that the citrus climatic suitability in subtropical China was decreasing, and had obvious regional differences, suggesting that climate change could bring about the changes in the regions suitable for citrus production and in the key stages of citrus growth.

  15. A fuzzy approach to a multiple criteria and Geographical Information System for decision support on suitable locations for biogas plants

    DEFF Research Database (Denmark)

    Franco, Camilo; Bojesen, Mikkel; Hougaard, Jens Leth

    2015-01-01

    The purpose of this paper is to model the multi-criteria decision problem of identifying the most suitable facility locations for biogas plants under an integrated decision support methodology. Here the Geographical Information System (GIS) is used for measuring the attributes of the alternatives...... according to a given set of criteria. Measurements are taken in interval form, expressing the natural imprecision of common data, and the Fuzzy Weighted Overlap Dominance (FWOD) procedure is applied for aggregating and exploiting this kind of data, obtaining suitability degrees for every alternative...... suitable sites for building biogas plants. We show that the FWOD relevance-ranking procedure can also be successfully applied over the outcomes of different decision makers, in case a unique social solution is required to exist. The proposed methodology can be used under an integrated decision support...

  16. Environmental assessment: Reference repository location, Hanford site, Washington

    Energy Technology Data Exchange (ETDEWEB)

    none,

    1986-05-01

    In February 1983, the US Department of Energy (DOE) identified a reference repository location at the Hanford Site in Washington as one of the nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. The site is in the Columbia Plateau, which is one of five distinct geohydrologic settings considered for the first repository. To determine their suitability, the Hanford Site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. These evaluations were reported in draft environmental assessments (EAs), which were issued for public review and comment. After considering the comments received on the draft EAs, the DOE prepared the final EAs. On the basis of the evaluations reported in this EA, the DOE has found that the Hanford site is not disqualified under the guidelines. The DOE has also found that it is suitable for site characterization because the evidence does not support a conclusion that the site will not be able to meet each of the qualifying conditions specified in the guidelines. On the basis of these findings, the DOE is nominating the Hanford site as one of five sites suitable for characterization.

  17. Environmental assessment: Reference repository location, Hanford site, Washington

    International Nuclear Information System (INIS)

    1986-05-01

    In February 1983, the US Department of Energy (DOE) identified a reference repository location at the Hanford Site in Washington as one of the nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. The site is in the Columbia Plateau, which is one of five distinct geohydrologic settings considered for the first repository. To determine their suitability, the Hanford Site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. These evaluations were reported in draft environmental assessments (EAs), which were issued for public review and comment. After considering the comments received on the draft EAs, the DOE prepared the final EAs. On the basis of the evaluations reported in this EA, the DOE has found that the Hanford site is not disqualified under the guidelines. The DOE has also found that it is suitable for site characterization because the evidence does not support a conclusion that the site will not be able to meet each of the qualifying conditions specified in the guidelines. On the basis of these findings, the DOE is nominating the Hanford site as one of five sites suitable for characterization

  18. CHARACTERISTICS AND SUITABILITY EVALUATION OF THE ...

    African Journals Online (AJOL)

    Ifedotun Aina

    suggested that the soils were not currently suitable for the production of the two ... crop – land suitability analysis has been used for achieving optimum utilization of the available ... Two methods of land suitability evaluation (FAO frame work and parametric) ..... Characterization and Classification of Onwu River Floodplain.

  19. Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

    Science.gov (United States)

    Malhotra, Deepti; Portales-Casamar, Elodie; Singh, Anju; Srivastava, Siddhartha; Arenillas, David; Happel, Christine; Shyr, Casper; Wakabayashi, Nobunao; Kensler, Thomas W.; Wasserman, Wyeth W.; Biswal, Shyam

    2010-01-01

    The Nrf2 (nuclear factor E2 p45-related factor 2) transcription factor responds to diverse oxidative and electrophilic environmental stresses by circumventing repression by Keap1, translocating to the nucleus, and activating cytoprotective genes. Nrf2 responses provide protection against chemical carcinogenesis, chronic inflammation, neurodegeneration, emphysema, asthma and sepsis in murine models. Nrf2 regulates the expression of a plethora of genes that detoxify oxidants and electrophiles and repair or remove damaged macromolecules, such as through proteasomal processing. However, many direct targets of Nrf2 remain undefined. Here, mouse embryonic fibroblasts (MEF) with either constitutive nuclear accumulation (Keap1−/−) or depletion (Nrf2−/−) of Nrf2 were utilized to perform chromatin-immunoprecipitation with parallel sequencing (ChIP-Seq) and global transcription profiling. This unique Nrf2 ChIP-Seq dataset is highly enriched for Nrf2-binding motifs. Integrating ChIP-Seq and microarray analyses, we identified 645 basal and 654 inducible direct targets of Nrf2, with 244 genes at the intersection. Modulated pathways in stress response and cell proliferation distinguish the inducible and basal programs. Results were confirmed in an in vivo stress model of cigarette smoke-exposed mice. This study reveals global circuitry of the Nrf2 stress response emphasizing Nrf2 as a central node in cell survival response. PMID:20460467

  20. Draft environmental assessment: Davis Canyon site, Utah. Nuclear Waste Policy Act (Section 112)

    International Nuclear Information System (INIS)

    1984-12-01

    In February 1983, the US Department of Energy (DOE) identified the Davis Canyon site in Utah, as one of nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Davis Canyon site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for Nuclear Waste Repositories. These evaluations are reported in this draft environmental assessment (EA), which is being issued for public review and comment. The DOE findings and determinations that are based on these evaluations are preliminary and subject to public review and comment. A final EA will be prepared after considering the comments received. On the basis of the evaluations reported in this draft EA, the DOE has found that the Davis Canyon site is not disqualified under the guidelines. The site is in the Paradox Basin, which is one of five distinct geohydrologic settings considered for the first repository. This setting contains one other potentially acceptable site - the Lavender Canyon site. Although the Lavender Canyon site appears to be suitable for site characterization, the DOE has concluded that the Davis Canyon site is the preferred site in the Paradox Basin. Furthermore, the DOE finds that the site is suitable for site characterization because the evidence does not support a conclusion that the site will not be able to meet each of the qualifying conditions specified in the guidelines. On the basis of these findings, the DOE is proposing to nominate the Davis Canyon site as one of five sites suitable for characterization. Having compared the Davis Canyon site with the other four sites proposed for nomination, the DOE has determined that the Davis Canyon site is not one of the three preferred sites for recommendation to the President as candidates for characterization

  1. Draft environmental assessment: Deaf Smith County site, Texas. Nuclear Waste Policy Act (Section 112)

    International Nuclear Information System (INIS)

    1984-12-01

    In February 1983, the US Department of Energy identified a location in Deaf Smith County, Texas, as one of nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. The potentially acceptable site was subsequently narrowed to an area of 9 square miles. To determine their suitability, the Deaf Smith site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for Nuclear Waste Repositories. These evaluations are reported in this draft environmental assessment, which is being issued for public review and comment. The DOE findings and determinations that are based on these evaluations are preliminary and subject to public review and comment. A final EA will be prepared after considering the comments received. On the basis of the evaluations reported in this draft EA, the DOE has found that the Deaf Smith site is not disqualified under the guidelines. The site is in the Permian Basin, which is one of five distinct geohydrologic settings considered for the first repository. This setting contains one other potentially acceptable site - the Swisher site. Although the Swisher site appears to be suitable for site characterization, DOE has concluded that the Deaf Smith site is the preferred site. The DOE finds that the site is suitable for site characterization because the evidence does not support a conclusion that the site will not be able to meet each of the qualifying conditions specified in the guidelines. On the basis of these findings, the DOE is proposing to nominate the Deaf Smith site as one of five sites suitable for characterization. Having compared the Deaf Smith site with the other four sites proposed for nomination, the DOE has determined that the Deaf Smith site is one of the three preferred sites for recommendation to the President as candidates for characterization

  2. Environmental assessment: Deaf Smith County site, Texas

    Energy Technology Data Exchange (ETDEWEB)

    1986-05-01

    In February 1983, the US Department of Energy (DOE) identified a location in Deaf Smith County, Texas, as one of the nine potentially acceptable sites for mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Deaf Smith County site and eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. The Deaf Smith County site is in the Permian Basin, which is one of five distinct geohydrologic settings considered for the first repository. On the basis of the evaluations reported in this EA, the DOE has found that the Deaf Smith County site is not disqualified under the guidelines.

  3. Environmental assessment: Deaf Smith County site, Texas

    International Nuclear Information System (INIS)

    1986-05-01

    In February 1983, the US Department of Energy (DOE) identified a location in Deaf Smith County, Texas, as one of the nine potentially acceptable sites for mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Deaf Smith County site and eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. The Deaf Smith County site is in the Permian Basin, which is one of five distinct geohydrologic settings considered for the first repository. On the basis of the evaluations reported in this EA, the DOE has found that the Deaf Smith County site is not disqualified under the guidelines

  4. LIBRA: LIgand Binding site Recognition Application.

    Science.gov (United States)

    Hung, Le Viet; Caprari, Silvia; Bizai, Massimiliano; Toti, Daniele; Polticelli, Fabio

    2015-12-15

    In recent years, structural genomics and ab initio molecular modeling activities are leading to the availability of a large number of structural models of proteins whose biochemical function is not known. The aim of this study was the development of a novel software tool that, given a protein's structural model, predicts the presence and identity of active sites and/or ligand binding sites. The algorithm implemented by ligand binding site recognition application (LIBRA) is based on a graph theory approach to find the largest subset of similar residues between an input protein and a collection of known functional sites. The algorithm makes use of two predefined databases for active sites and ligand binding sites, respectively, derived from the Catalytic Site Atlas and the Protein Data Bank. Tests indicate that LIBRA is able to identify the correct binding/active site in 90% of the cases analyzed, 90% of which feature the identified site as ranking first. As far as ligand binding site recognition is concerned, LIBRA outperforms other structure-based ligand binding sites detection tools with which it has been compared. The application, developed in Java SE 7 with a Swing GUI embedding a JMol applet, can be run on any OS equipped with a suitable Java Virtual Machine (JVM), and is available at the following URL: http://www.computationalbiology.it/software/LIBRAv1.zip. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  5. Solar Farm Suitability Using Geographic Information System Fuzzy Sets and Analytic Hierarchy Processes: Case Study of Ulleung Island, Korea

    Directory of Open Access Journals (Sweden)

    Jangwon Suh

    2016-08-01

    Full Text Available Solar farm suitability in remote areas will involve a multi-criteria evaluation (MCE process, particularly well suited for the geographic information system (GIS environment. Photovoltaic (PV solar farm criteria were evaluated for an island-based case region having complex topographic and regulatory criteria, along with high demand for low-carbon local electricity production: Ulleung Island, Korea. Constraint variables that identified areas forbidden to PV farm development were consolidated into a single binary constraint layer (e.g., environmental regulation, ecological protection, future land use. Six factor variables were selected as influential on-site suitability within the geospatial database to seek out increased annual average power performance and reduced potential investment costs, forming new criteria layers for site suitability: solar irradiation, sunshine hours, average temperature in summer, proximity to transmission line, proximity to roads, and slope. Each factor variable was normalized via a fuzzy membership function (FMF and parameter setting based on the local characteristics and criteria for a fixed axis PV system. Representative weighting of the relative importance for each factor variable was assigned via pairwise comparison completed by experts. A suitability index (SI with six factor variables was derived using a weighted fuzzy summation method. Sensitivity analysis was conducted to assess four different SI based on the development scenarios (i.e., the combination of factors being considered. From the resulting map, three highly suitable regions were suggested and validated by comparison with satellite images to confirm the candidate sites for solar farm development. The GIS-MCE method proposed can also be applicable widely to other PV solar farm site selection projects with appropriate adaption for local variables.

  6. Draft environmental assessment: Vacherie Dome site, Louisiana. Nuclear Waste Policy Act (Section 112)

    International Nuclear Information System (INIS)

    1984-12-01

    In February 1983, the US Department of Energy (DOE) identified the Vacherie dome in Louisiana as one of nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Vacherie dome site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for Nuclear Waste Repositories. These evaluations are reported in this draft environmental assessment (EA), which is being issued for public review and comment. The DOE findings and determinations that are based on these evaluations are preliminary and subject to public review and comment. A final EA will be prepared after considering the comments received. On the basis of the evaluations contained in this draft EA, the DOE has found that the Vacherie dome site is not disqualified under the guidelines. The site is contained in the Gulf Interior Region of the Gulf Coastal Plain, which is one of five distinct geohydrologic settings considered for the first repository. This setting contains two other potentially acceptable sites - the Cypress Creek dome site and the Richton dome site. Although the Vacherie dome site appears to be suitable for site characterization, the DOE has concluded that the Richton dome site is the preferred site in the Gulf Interior Region. On the basis of these findings, the DOE is proposing to nominate the Richton dome site rather than the Vacherie dome site as one of the five sites suitable for characterization

  7. Draft environmental assessment: Swisher County site, Texas. Nuclear Waste Policy Act (Section 112)

    International Nuclear Information System (INIS)

    1984-12-01

    In February 1983, the US Department of Energy (DOE) identified a location in Swisher County, Texas, as one of nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. The potentially acceptable site was subsequently narrowed to an area of 9 square miles. To determine their suitability, the Swisher site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for Nuclear Waste Repositories. These evaluations are reported in this draft environmental assessment (EA), which is being issued for public review and comment. The DOE findings and determinations that are based on these evaluations are preliminary and subject to public review and comment. A final EA will be prepared after considering the comments received. On the basis of the evaluations contained in this draft EA, the DOE has found that the Swisher site is not disqualified under the guidelines. The site is contained in the Permian Basin, which is one of five distinct geohydrologic settings considered for the first repository. This setting contains one other potentially acceptable site - the Deaf Smith site. Although the Swisher site appears to be suitable for site characterization, the DOE has concluded that the Deaf Smith site is the preferred site in the Permian Basin and is proposing to nominate the Deaf Smith site rather than the Swisher site as one of the five sites suitable for characterization

  8. Draft environmental assessment: Lavender Canyon site, Utah. Nuclear Waste Policy Act (Section 112)

    International Nuclear Information System (INIS)

    1984-12-01

    In February 1983, the US Department of Energy (DOE) identified the Lavender Canyon site in Utah, as one of nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Lavender Canyon site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for Nuclear Waste Repositories. These evaluations are reported in this draft environmental assessment (EA), which is being issued for public review and comment. The DOE findings and determinations that are based on these evaluations are preliminary and subject to public review and comment. A final EA will be prepared after considering the comments received. On the basis of the evaluations contained in this draft EA, the DOE has found that the Lavender Canyon site is not disqualified under the guidelines. The site is contained in the Paradox Basin, which is one of five distinct geohydrologic settings considered for the first repository. This setting contains one other potentially acceptable site - the Davis Canyon site. Although the Lavender Canyon site appears to be suitable for site characterization, the DOE has concluded that the Davis Canyon site is the preferred site in the Paradox Basin. On the basis of these findings, the DOE is proposing to nominate the Davis Canyon site rather than the Lavender Canyon site as one of the five sites suitable for characterization

  9. Suitability of amphibians and reptiles for translocation.

    Science.gov (United States)

    Germano, Jennifer M; Bishop, Phillip J

    2009-02-01

    Translocations are important tools in the field of conservation. Despite increased use over the last few decades, the appropriateness of translocations for amphibians and reptiles has been debated widely over the past 20 years. To provide a comprehensive evaluation of the suitability of amphibians and reptiles for translocation, we reviewed the results of amphibian and reptile translocation projects published between 1991 and 2006. The success rate of amphibian and reptile translocations reported over this period was twice that reported in an earlier review in 1991. Success and failure rates were independent of the taxonomic class (Amphibia or Reptilia) released. Reptile translocations driven by human-wildlife conflict mitigation had a higher failure rate than those motivated by conservation, and more recent projects of reptile translocations had unknown outcomes. The outcomes of amphibian translocations were significantly related to the number of animals released, with projects releasing over 1000 individuals being most successful. The most common reported causes of translocation failure were homing and migration of introduced individuals out of release sites and poor habitat. The increased success of amphibian and reptile translocations reviewed in this study compared with the 1991 review is encouraging for future conservation projects. Nevertheless, more preparation, monitoring, reporting of results, and experimental testing of techniques and reintroduction questions need to occur to improve translocations of amphibians and reptiles as a whole.

  10. Environmental assessment overview, Yucca Mountain site, Nevada Research and Development Area, Nevada

    International Nuclear Information System (INIS)

    1986-05-01

    In February 1983, the US Department of Energy (DOE) identified the Yucca Mountain site in Nevada as one of nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. The site is in the Great Basin, which is one of five distinct geohydrologic settings considered for the first repository. To determine their suitability, the Yucca Mountain site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendations of Sites for the Nuclear Waste Repositories. On the basis of the evaluations reported in this EA, the DOE has found that the Yucca Mountain site is not disqualified under the guidelines. On the basis of these findings, the DOE is nominating the Yucca Mountain site as one of five sites suitable for characterization. 3 figs

  11. Probabilistic performance assessments for evaluations of the Yucca Mountain site

    International Nuclear Information System (INIS)

    Rickertsen, L.D.; Noronha, C.J.

    1992-01-01

    Site suitability evaluations are conducted to determine if a repository system at a particular site will be able to meet the performance objectives for that system. Early evaluations to determine if the Yucca Mountain site is suitable for repository development have been made in the face of large uncertainties in site features and conditions. Because of these large uncertainties, the evaluations of the site have been qualitative in nature, focusing on the presence or absence of particular features or conditions thought to be important to performance, rather than on results of quantitative performance assessments. Such a qualitative approach was used in the recently completed evaluation of the Yucca Mountain site, the Early Site-Suitability Evaluation (ESSE). In spite of the qualitative approach, the ESSE was able to conclude that no disqualifying conditions are likely to be present at the site and that all of the geologic conditions that would qualify the site are likely to be met. At the same time, because of the qualitative nature of the approach used in the ESSE, the precise importance of the identified issues relative to performance could not be determined. Likewise, the importance of the issues relative to one another could not be evaluated, and, other than broad recommendations, specific priorities for future testing could not be set. The authors have conducted quantitative performance assessments for the Yucca Mountain site to address these issues

  12. Salt site performance assessment activities

    International Nuclear Information System (INIS)

    Kircher, J.F.; Gupta, S.K.

    1983-01-01

    During this year the first selection of the tools (codes) for performance assessments of potential salt sites have been tentatively selected and documented; the emphasis has shifted from code development to applications. During this period prior to detailed characterization of a salt site, the focus is on bounding calculations, sensitivity and with the data available. The development and application of improved methods for sensitivity and uncertainty analysis is a focus for the coming years activities and the subject of a following paper in these proceedings. Although the assessments to date are preliminary and based on admittedly scant data, the results indicate that suitable salt sites can be identified and repository subsystems designed which will meet the established criteria for protecting the health and safety of the public. 36 references, 5 figures, 2 tables

  13. Methodology for selecting low-level radioactive waste disposal sites with application to the Oak Ridge Reservation

    International Nuclear Information System (INIS)

    Lee, D.W.; Ketelle, R.H.

    1984-01-01

    A methodology was developed to select an environmentally acceptable site for low-level radioactive waste disposal for a predetermined region of interest using prescribed site suitability requirements. The methodology provides a defensible means for identifying candidate areas within the region, candidate sites within the areas, and an environmentally preferred site from the candidate sites. This is accomplished in site screening and site characterization stages. The site screening stage relies on reconnaissance data to identify a preferred site. The site characterization stage relies on a detailed site investigation to determine site acceptability. The methodology was applied to the US Department of Energy Oak Ridge Reservation through the site screening stage. 6 references, 3 figures, 7 tables

  14. LAND SUITABILITY SCENARIOS FOR ARID COASTAL PLAINS USING GIS MODELING: SOUTHWESTERN SINAI COASTAL PLAIN, EGYPT

    Directory of Open Access Journals (Sweden)

    Ahmed Mohamed Wahid

    2009-12-01

    Full Text Available Site selection analysis was carried out to find the best suitable lands for development activities in an example of promising coastal plains, southwestern Sinai, Egypt. Two GIS models were developed to represent two scenarios of land use suitability in the study area using GIS Multi Criteria Analysis Modeling. The factors contributed in the analysis are the Topography, Land cover, Existing Land use, Flash flood index, Drainage lines and Water points. The first scenario was to classify the area according to various gradual ranges of suitability. According to this scenario, the area is classified into five classes of suitability. The percentage of suitability values are 51.16, 6.13, 22.32, 18.49 and 1.89% for unsuitable, least suitable, low suitable, suitable and high suitable, respectively. The second scenario is developed for a particular kind of land use planning; tourism and recreation projects. The suitability map of this scenario was classified into five values. Unsuitable areas represent 51.18% of the study area, least suitable 16.67%, low suitable 22.85%, suitable 8.61%, and high suitable 0.68%. The best area for locating development projects is the area surrounding El-Tor City and close to the coast. This area could be an urban extension of El-Tor City with more economical and environmental management.

  15. Identifying unstable sites on logging roads

    Science.gov (United States)

    R. M. Rice; J. Lewis

    1986-01-01

    Logging roads are an important source of forestry-related erosion. The amount of erosion on a forest road is determined by the interaction between how the road is constructed and maintained and the environment in which it is built. The roads in this study were constructed with large bulldozers, and most excavated material was sidecast. The roads studied were...

  16. Site characterization studies in the NWTS program

    International Nuclear Information System (INIS)

    Shipler, D.; Evans, G.

    1980-01-01

    The US Department of Energy (DOE) has the responsibility to identify sites and construct and operate facilities for the storage or isolation of spent fuel and/or reprocessing radioactive wastes from commercial nuclear power plants. The National Waste Terminal Storage (NWTS) Program has been initiated by the DOE to develop the technology and demonstrate the feasibility of burial and isolation of high level radioactive waste in deep geologic formations. The NTWS Program plan which sets forth the criteria, procedures, and other considerations required to characterize and select a site in a comprehensive stepwise manner is discussed. The plan is not specific to any given geologic medium but serves as a guide for site selection in any geohydrologic system deemed appropriate for consideration for a deep geologic repository. The plan will be used by all NWTS Project Offices in the conduct of their site characterization program. The plan will be updated, as warranted, to reflect technology development, National policies, rulemakings by regulatory agencies, and other changing political, social, and institutional considerations. Site characterization begins with the identification of regions believed to have suitable geologic, hydrologic, and environmental characteristics for repository siting. This is followed by an iterative process of data collection and analysis to identify areas and locations which appear most suitable for further investigations. In addition, screening studies of the DOE's nuclear complexes has led to the selection of the Nevada Test Site and the Hanford Site for further characterization studies. The site characterization process results in a number of candidate sites from which a site will be selected and proposed to the NRC for licensing

  17. Engineering study of generic site criteria for selected DOE plutonium facilities

    International Nuclear Information System (INIS)

    Kingsbury, R.J.; Greenwood, J.M.; Sandoval, M.D.

    1980-09-01

    The objectives of this study were to identify criteria that would be applied to selection of a site for plutonium facilities such as those at the Rocky Flats Plant, to establish the relative importance of these criteria, and to identify suitable areas within the United States for location of plutonium facilities with respect to these criteria. Sources of the site criteria identified include federal laws, federal agency regulations, state laws and regulations, and requirements associated with operations to be performed at the site. The criteria identified during the study were organized into 14 major categories. The relative importnace of each category and each criterion within the categories were established using group decision-making techniques. The major criteria categories, their assigned weight on a scale of 1 to 10, and their relative priority ranks are as follows: geology/seismicity; public safety; environmental impact; meteorology; hydrology; topography; transportation; utilities; personnel; safeguards/security; land area and availability; land use compatibility; and, public acceptance. A suitability analysis of the continental United States was performed using only those criteria that could be mapped at a national scale. Suitability was assessed with respect to each of these criteria, and individual suitability maps were prepared. A composite suitability map was generated using computerized overlay techniques. This map provides a starting point for identifying specific candidate sites if an actual site selection were to be conducted

  18. Execution programme for the initial site investigations at Forsmark

    International Nuclear Information System (INIS)

    2002-05-01

    In the feasibility studies that were completed in 2001, eight sites were identified as potentially suitable for hosting a repository. All the identified sites meet the safety requirements with respect to bedrock conditions that could be checked at that time. The feasibility studies have revealed good potential when it comes to the technical and environmental aspects as well. Based on an integrated evaluation SKB proposed to start site investigations with test drillings at three sites; Forsmark, Simpevarp and Tierp. Site investigations have started at Forsmark and Simpevarp. The municipal council of Tierp voted no to a site investigation in April 2002. The site investigations are divided into two main phases; initial and complete investigations. Initial site investigations are performed to identify the site within a specified area that is deemed to be most suitable for a deep repository and to determine whether the feasibility study's judgement of the suitability of the area holds up in the light of borehole data from repository depth. The initial site investigations are expected to take 1.5-2 years. If the assessment shows that the site has good potential to host a repository, complete site investigations will follow for an expected duration of 3.5-4 years. The purpose of the complete site investigations is to gather all information required to select one of the sites as the main alternative and to apply for a permit for construction of the deep repository at that site. A general programme in which the results from feasibility studies are summarized, the candidate sites presented and the framework of programme for the site investigation phase presented has been published. The general programme, and main references to the programme, specifies which data are required in order to design the repository and carry out a safety assessment, how the investigations should be carried out in order to provide these data, criteria with which the site must comply, as well as

  19. Execution programme for the initial site investigations at Forsmark

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-05-01

    In the feasibility studies that were completed in 2001, eight sites were identified as potentially suitable for hosting a repository. All the identified sites meet the safety requirements with respect to bedrock conditions that could be checked at that time. The feasibility studies have revealed good potential when it comes to the technical and environmental aspects as well. Based on an integrated evaluation SKB proposed to start site investigations with test drillings at three sites; Forsmark, Simpevarp and Tierp. Site investigations have started at Forsmark and Simpevarp. The municipal council of Tierp voted no to a site investigation in April 2002. The site investigations are divided into two main phases; initial and complete investigations. Initial site investigations are performed to identify the site within a specified area that is deemed to be most suitable for a deep repository and to determine whether the feasibility study's judgement of the suitability of the area holds up in the light of borehole data from repository depth. The initial site investigations are expected to take 1.5-2 years. If the assessment shows that the site has good potential to host a repository, complete site investigations will follow for an expected duration of 3.5-4 years. The purpose of the complete site investigations is to gather all information required to select one of the sites as the main alternative and to apply for a permit for construction of the deep repository at that site. A general programme in which the results from feasibility studies are summarized, the candidate sites presented and the framework of programme for the site investigation phase presented has been published. The general programme, and main references to the programme, specifies which data are required in order to design the repository and carry out a safety assessment, how the investigations should be carried out in order to provide these data, criteria with which the site must comply, as well as

  20. Ecological variables governing habitat suitability and the distribution ...

    African Journals Online (AJOL)

    governed by soil particle size distribution), in combination with the cover provided by trees, as the two ecological factors that best explained habitat suitability for Juliana's golden mole at the three localities. An IndVal analysis failed to identify ...

  1. Siting Evaluation for Biomass-Ethanol Production in Hawaii

    Energy Technology Data Exchange (ETDEWEB)

    Kinoshita, C.M.; Zhou, J.

    2000-10-15

    This report examines four Hawaiian islands, Oahu, Hawaii, Maui, and Kauai, to identify three best combinations of potential sites and crops for producing dedicated supplies of biomass for conversion to ethanol. Key technical and economic factors considered in the siting evaluation include land availability (zoning and use), land suitability (agronomic conditions), potential quantities and costs of producing biomass feedstocks, infrastructure (including water and power supplies), transportation, and potential bioresidues to supplement dedicated energy crops.

  2. Environmental Modeling, The Natural Filter Wetland Priority layers identify priority wetland restoration sites by subwatershed. Land use, hydrology, soil, and landscape characteristics were analyzed to rank opportunities with high nutrient removal potential., Published in 2014, Smaller than 1:100000 scale, Maryland Department of Natural Resources (DNR).

    Data.gov (United States)

    NSGIC Education | GIS Inventory — Environmental Modeling dataset current as of 2014. The Natural Filter Wetland Priority layers identify priority wetland restoration sites by subwatershed. Land use,...

  3. Is Switzerland suitable for the invasion of Aedes albopictus [corrected]?

    Science.gov (United States)

    Neteler, Markus; Metz, Markus; Rocchini, Duccio; Rizzoli, Annapaola; Flacio, Eleonora; Engeler, Luca; Guidi, Valeria; Lüthy, Peter; Tonolla, Mauro

    2013-01-01

    Over the last 30 years, the Asian tiger mosquito, Aedes albopictus, has rapidly spread around the world. The European distribution comprises the Mediterranean basin with a first appearance in Switzerland in 2003. Early identification of the most suitable areas in Switzerland allowing progressive invasion by this species is considered crucial to suggest adequate surveillance and control plans. We identified the most suitable areas for invasion and establishment of Ae. albopictus in Switzerland. The potential distribution areas linked to the current climatic suitability were assessed using remotely sensed land surface temperature data recorded by the MODIS satellite sensors. Suitable areas for adult survival and overwintering of diapausing eggs were also identified for future climatic conditions, considering two different climate change scenarios (A1B, A2) for the periods 2020-2049 and 2045-2074. At present, the areas around Lake Geneva in western Switzerland provide suitable climatic conditions for Ae. albopictus. In northern Switzerland, parts of the Rhine valley, around Lake Constance, as well as the surroundings of Lake Neuchâtel, appear to be suitable for the survival at least of adult Ae. albopictus. However, these areas are characterized by winters currently being too cold for survival and development of diapausing eggs. In southern Switzerland, Ae. albopictus is already well-established, especially in the Canton of Ticino. For the years 2020-2049, the predicted possible spread of the tiger mosquito does not differ significantly from its potential current distribution. However, important expansions are obtained if the period is extended to the years 2045-2074, when Ae. albopictus may invade large new areas. Several parts of Switzerland provide suitable climatic conditions for invasion and establishment of Ae. albopictus. The current distribution and rapid spread in other European countries suggest that the tiger mosquito will colonize new areas in Switzerland

  4. Is Switzerland Suitable for the Invasion of Aedes albopictus?

    Science.gov (United States)

    Neteler, Markus; Metz, Markus; Rocchini, Duccio; Rizzoli, Annapaola; Flacio, Eleonora; Engeler, Luca; Guidi, Valeria; Lüthy, Peter; Tonolla, Mauro

    2013-01-01

    Background Over the last 30 years, the Asian tiger mosquito, Aedes albopictus, has rapidly spread around the world. The European distribution comprises the Mediterranean basin with a first appearance in Switzerland in 2003. Early identification of the most suitable areas in Switzerland allowing progressive invasion by this species is considered crucial to suggest adequate surveillance and control plans. Methodology/Principal Findings We identified the most suitable areas for invasion and establishment of Ae. albopictus in Switzerland. The potential distribution areas linked to the current climatic suitability were assessed using remotely sensed land surface temperature data recorded by the MODIS satellite sensors. Suitable areas for adult survival and overwintering of diapausing eggs were also identified for future climatic conditions, considering two different climate change scenarios (A1B, A2) for the periods 2020–2049 and 2045–2074. At present, the areas around Lake Geneva in western Switzerland provide suitable climatic conditions for Ae. albopictus. In northern Switzerland, parts of the Rhine valley, around Lake Constance, as well as the surroundings of Lake Neuchâtel, appear to be suitable for the survival at least of adult Ae. albopictus. However, these areas are characterized by winters currently being too cold for survival and development of diapausing eggs. In southern Switzerland, Ae. albopictus is already well-established, especially in the Canton of Ticino. For the years 2020–2049, the predicted possible spread of the tiger mosquito does not differ significantly from its potential current distribution. However, important expansions are obtained if the period is extended to the years 2045–2074, when Ae. albopictus may invade large new areas. Conclusions/Significance Several parts of Switzerland provide suitable climatic conditions for invasion and establishment of Ae. albopictus. The current distribution and rapid spread in other European

  5. Ocean Disposal Site Monitoring

    Science.gov (United States)

    EPA is responsible for managing all designated ocean disposal sites. Surveys are conducted to identify appropriate locations for ocean disposal sites and to monitor the impacts of regulated dumping at the disposal sites.

  6. Promoting Your Web Site.

    Science.gov (United States)

    Raeder, Aggi

    1997-01-01

    Discussion of ways to promote sites on the World Wide Web focuses on how search engines work and how they retrieve and identify sites. Appropriate Web links for submitting new sites and for Internet marketing are included. (LRW)

  7. SITE-2, Power Plant Siting, Cost, Environment, Seismic and Meteorological Effects

    International Nuclear Information System (INIS)

    Frigerio, N.A.; Habegger, L.J.; King, R.F.; Hoover, L.J.; Clark, N.A.; Cobian, J.M.

    1977-01-01

    1 - Description of problem or function: SITE2 is designed to (1) screen candidate energy facility sites or areas within an electric utility region, based on the region's physical and socioeconomic attributes, the planned facility's characteristics, and impact assessments, and (2) evaluate the cumulative regional impacts associated with alternate energy supply options and inter-regional energy import/export practices, specifically, comparison of different energy technologies and their regional distribution in clustered or dispersed patterns. 2 - Method of solution: The SITE2 methodology is based on the quantification of three major site-related vectors. A cost vector is determined which identifies site-specific costs, such as transmission costs, cooling costs as related to water availability, and costs of specific controls needed to protect the surrounding environment. An impact vector is also computed for each potential site, using models of health and environmental impacts incurred in areas adjacent to the site. Finally, a site attribute vector is developed which reflects such characteristics as population, seismic conditions, meteorology, land use, and local ecological systems. This vector can be used to eliminate certain sites because of their inability to satisfy specific constraints. These three vectors can be displayed as density maps and combined in a simple overlay approach, similar to that developed by I. L. McHarg in reference 2, to identify candidate sites. Alternatively, the vector elements can be computationally combined into a weighted sum to obtain quantitative indicators of site suitability

  8. SITE-2, Power Plant Siting, Cost, Environment, Seismic and Meteorological Effects

    Energy Technology Data Exchange (ETDEWEB)

    Frigerio, N A [Environmental Impact Studies, Argonne National Laboratory 9700 South Cass Avenue, Argonne, Illinois 60439 (United States); Habegger, L J; King, R F; Hoover, L J [Energy and Environmental Systems Division, Argonne National Laboratory 9700 South Cass Avenue, Argonne, Illinois 60439 (United States); Clark, N A [Applied Mathematics Division, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, Illinois 60439 (United States); Cobian, J M [Northwestern University, Evanston, Illinois 60201 (United States)

    1977-08-01

    1 - Description of problem or function: SITE2 is designed to (1) screen candidate energy facility sites or areas within an electric utility region, based on the region's physical and socioeconomic attributes, the planned facility's characteristics, and impact assessments, and (2) evaluate the cumulative regional impacts associated with alternate energy supply options and inter-regional energy import/export practices, specifically, comparison of different energy technologies and their regional distribution in clustered or dispersed patterns. 2 - Method of solution: The SITE2 methodology is based on the quantification of three major site-related vectors. A cost vector is determined which identifies site-specific costs, such as transmission costs, cooling costs as related to water availability, and costs of specific controls needed to protect the surrounding environment. An impact vector is also computed for each potential site, using models of health and environmental impacts incurred in areas adjacent to the site. Finally, a site attribute vector is developed which reflects such characteristics as population, seismic conditions, meteorology, land use, and local ecological systems. This vector can be used to eliminate certain sites because of their inability to satisfy specific constraints. These three vectors can be displayed as density maps and combined in a simple overlay approach, similar to that developed by I. L. McHarg in reference 2, to identify candidate sites. Alternatively, the vector elements can be computationally combined into a weighted sum to obtain quantitative indicators of site suitability.

  9. A GIS-BASED MULTI-CRITERIA EVALUATION SYSTEM FOR SELECTION OF LANDFILL SITES: a case study from Abu Dhabi, United Arab Emirates

    Directory of Open Access Journals (Sweden)

    S. M. Issa

    2012-07-01

    Full Text Available Landfill sites receive 92% of total annual solid waste produced by municipalities in the emirate of Abu Dhabi. In this study, candidate sites for an appropriate landfill location for the Abu Dhabi municipal area are determined by integrating geographic information systems (GIS and multi-criteria evaluation (MCE analysis. To identify appropriate landfill sites, eight input map layers including proximity to urban areas, proximity to wells and water table depth, geology and topography, proximity to touristic and archeological sites, distance from roads network, distance from drainage networks, and land slope are used in constraint mapping. A final map was generated which identified potential areas showing suitability for the location of the landfill site. Results revealed that 30% of the study area was identified as highly suitable, 25% as suitable, and 45% as unsuitable. The selection of the final landfill site, however, requires further field research.

  10. Exploring the influence of EGCG on the β-sheet-rich oligomers of human islet amyloid polypeptide (hIAPP1-37 and identifying its possible binding sites from molecular dynamics simulation.

    Directory of Open Access Journals (Sweden)

    Qianqian Wang

    Full Text Available EGCG possesses the ability of disaggregating the existing amyloid fibrils which were associated with many age-related degenerative diseases. However, the molecular mechanism of EGCG to disaggregate these fibrils is poorly known. In this work, to study the influence of EGCG on the full-length human islet amyloid polypeptide 1-37 (hIAPP1-37 oligomers, molecular dynamics simulations of hIAPP1-37 pentamer and decamer with EGCG were performed, respectively. The obtained results indicate that EGCG indeed destabilized the hIAPP1-37 oligomers. The nematic order parameter and secondary structure calculations coupled with the free-energy landscape indicate that EGCG broke the initial ordered pattern of two polymers, greatly reduced their β-sheet content and enlarged their conformational space. On this basis, three possible target sites were identified with the binding capacity order of S1>S2>S3. After a deeper analysis of each site, we found that S1 was the most possible site on which residues B-Ile26/Ala25, A-Phe23, B/C-Leu27 and E-Tyr37 played an important role for their binding. The proposal of this molecular mechanism can not only provide a prospective interaction figure between EGCG and β-sheet-rich fibrils of hIAPP1-37, but also is useful for further discovering other potential inhibitors.

  11. Biomonitors of urban air pollution: Magnetic studies and SEM observations of corticolous foliose and microfoliose lichens and their suitability for magnetic monitoring

    International Nuclear Information System (INIS)

    Chaparro, Marcos A.E.; Lavornia, Juan M.; Chaparro, Mauro A.E.; Sinito, Ana M.

    2013-01-01

    This study explored the suitability of available lichen species as air pollution biomonitors and assessed their potential for magnetic monitoring in cities. Several lichens on tree bark were collected in urban and industrial sites from Tandil city, as well as control sites. The results showed that magnetite-like minerals were the main magnetic carriers in all sites and samples. However, the concentration varied between clean and polluted sites. In addition, magnetic-grain size-distribution showed clear differences between sites. Observations by scanning electron microscopy showed different particles in a variety of shapes and grain sizes; moreover, the presence of iron oxides and several toxic elements was detected by energy dispersive spectroscopy analysis. Although eleven lichen species were identified that appeared suitable for use as air-pollution monitors, three of them, Parmotrema pilosum, Punctelia hipoleucites and Dirinaria picta, occurred more frequently in the area, thus constituting appropriate species for future monitoring in the study area. - Highlights: ► Magnetite-like minerals are the main carriers in lichen samples. ► Magnetic concentration and grain sizes vary between polluted and control sites. ► Different pollution loads were classified from pcoorda and K-means clustering analysis. ► Parmotrema pilosum, Punctelia hipoleucites and Dirinaria picta appear to be suitable air pollution monitors. - Lichen species are airborne pollutant collectors that are well-distributed in some urban areas and allow effective magnetic monitoring at low cost in cities.

  12. Identification of sumoylation sites in CCDC6, the first identified RET partner gene in papillary thyroid carcinoma, uncovers a mode of regulating CCDC6 function on CREB1 transcriptional activity.

    Directory of Open Access Journals (Sweden)

    Chiara Luise

    Full Text Available CCDC6 was originally identified in chimeric genes as caused by chromosomal translocation involving the RET protooncogene in some thyroid tumors. Recognised as a 65 kDa pro-apoptotic phosphoprotein, CCDC6 has been enrolled as an ATM substrate that contribute to protect genome integrity by modulating PP4c activity in response to genotoxic stress. Recently, CCDC6 has been identified as a repressor of CREB1-dependent transcription. Sumoylation has emerged as an important mechanism in transcriptional control. Here, we report the identification and characterization of three sites of sumoylation in CCDC6 (K74, K266 and K424 which are highly conserved in vertebrates. We demonstrate that the post-translational modifications by SUMO2 constrain most of the CCDC6 protein in the cytosol and affect its functional interaction with CREB1 with a decrease of CCDC6 repressive function on CREB1 transcriptional activity. Indeed, the impairment of functional outcome of sumoylated CCDC6 is obtained knocking down all three the sumoylation sites. Interestingly, in thyroid cells the SUMO2-mediated CCDC6 post-translational modifications are induced by Forskolin, a cAMP analog. Signal transduction via the cAMP pathway is known to be ubiquitous and represents a major line of communication between many organisms and their environment. We believe that CCDC6 could be an important player in the dynamics of cAMP signaling by fine regulating CREB1 transcriptional activity in normal and transformed thyroid cells.

  13. Site Selection for the Salt Disposition Facility at the Savannah River Site

    International Nuclear Information System (INIS)

    Gladden, J.B.; Rueter, K.J.; Morin, J.P.

    2000-01-01

    A site selection study was conducted to identify a suitable location for the construction and operation of a new Salt Disposition Facility (SDF) at the Savannah River Site (SRS). The facility to be sited is a single processing facility and support buildings that could house either of three technology alternatives being developed by the High Level Waste Systems Engineering Team: Small Tank Tetraphenylborate Precipitation, Crystalline Silicotitanate Non-Elutable Ion Exchange or Caustic Side Solvent Extraction. A fourth alternative, Direct Disposal in grout, is not part of the site selection study because a location has been identified that is unique to this technology (i.e., Z-Area). Facility site selection at SRS is a formal, documented process that seeks to optimize siting of new facilities with respect to facility-specific engineering requirements, sensitive environmental resources, and applicable regulatory requirements. In this manner, the prime objectives of cost minimization, environmental protection, and regulatory compliance are achieved. The results from this geotechnical characterization indicated that continued consideration be given to Site B for the proposed SDF. Suitable topography, the lack of surface hydrology and floodplain issues, no significant groundwater contamination, the presence of minor soft zones along the northeast portion of footprint, and no apparent geological structure in the Gordon Aquitard support this recommendation

  14. O-GlcNAcPRED-II: an integrated classification algorithm for identifying O-GlcNAcylation sites based on fuzzy undersampling and a K-means PCA oversampling technique.

    Science.gov (United States)

    Jia, Cangzhi; Zuo, Yun; Zou, Quan; Hancock, John

    2018-02-06

    Protein O-GlcNAcylation (O-GlcNAc) is an important post-translational modification of serine (S)/threonine (T) residues that involves multiple molecular and cellular processes. Recent studies have suggested that abnormal O-G1cNAcylation causes many diseases, such as cancer and various neurodegenerative diseases. With the available protein O-G1cNAcylation sites experimentally verified, it is highly desired to develop automated methods to rapidly and effectively identify O-G1cNAcylation sites. Although some computational methods have been proposed, their performance has been unsatisfactory, particularly in terms of prediction sensitivity. In this study, we developed an ensemble model O-GlcNAcPRED-II to identify potential O-G1cNAcylation sites. A K-means principal component analysis oversampling technique (KPCA) and fuzzy undersampling method (FUS) were first proposed and incorporated to reduce the proportion of the original positive and negative training samples. Then, rotation forest, a type of classifier-integrated system, was adopted to divide the eight types of feature space into several subsets using four sub-classifiers: random forest, k-nearest neighbour, naive Bayesian and support vector machine. We observed that O-GlcNAcPRED-II achieved a sensitivity of 81.05%, specificity of 95.91%, accuracy of 91.43% and Matthew's correlation coefficient of 0.7928 for five-fold cross-validation run 10 times. Additionally, the results obtained by O-GlcNAcPRED-II on two independent datasets also indicated that the proposed predictor outperformed five published prediction tools. http://121.42.167.206/OGlcPred/. cangzhijia@dlmu.edu.cn or zouquan@nclab.net. © The Author (2018). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com

  15. 78 FR 4160 - Federal Property Suitable as Facilities To Assist the Homeless

    Science.gov (United States)

    2013-01-18

    ... to the interim rule governing this program, 24 CFR part 581. For properties listed as suitable/to be... Status: Unutilized Comments: off-site removal only; 3,292 sf.; dining facility; good conditions...

  16. Environmental assessment: Reference repository location, Hanford site, Washington

    Energy Technology Data Exchange (ETDEWEB)

    none,

    1986-05-01

    In February 1983, the US Department of Energy (DOE) identified a reference repository location at the Hanford Site in Washington as one of the nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. The site is in the Columbia Plateau, which is one of five distinct geohydrologic settings considered for the first repository. To determine their suitability, the Hanford site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. These evaluations were reported in draft environmental assessments (EAs), which were issued for public review and comment. After considering the comments received on the draft EAs, the DOE prepared the final EAs. On the basis of the evaluations reported in this EA, the DOE has found that the Hanford site is not disqualified under the guidelines. The DOE has also found that is is suitable for site characterization because the evidence does not support a conclusion that the site will not be able to meet each of the qualifying conditions specified in the guidelines. On the basis of these findings, the DOE is nominating the Hanford site as one of five sites available for characterization.

  17. Environmental assessment: Reference repository location, Hanford site, Washington

    International Nuclear Information System (INIS)

    1986-05-01

    In February 1983, the US Department of Energy (DOE) identified a reference repository location at the Hanford Site in Washington as one of the nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. The site is in the Columbia Plateau, which is one of five distinct geohydrologic settings considered for the first repository. To determine their suitability, the Hanford site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. These evaluations were reported in draft environmental assessments (EAs), which were issued for public review and comment. After considering the comments received on the draft EAs, the DOE prepared the final EAs. On the basis of the evaluations reported in this EA, the DOE has found that the Hanford site is not disqualified under the guidelines. The DOE has also found that is is suitable for site characterization because the evidence does not support a conclusion that the site will not be able to meet each of the qualifying conditions specified in the guidelines. On the basis of these findings, the DOE is nominating the Hanford site as one of five sites available for characterization

  18. Land Suitability Assessment for Sugarcane in "Herois de Caxito" (Angola

    Directory of Open Access Journals (Sweden)

    Baert, G.

    2005-01-01

    Full Text Available The suitability of the soils surrounding the sugarcane plantation at "Herois de Caxito" (7068 ha is assessed. The main goal is to identify land suitability for the enlargement of the present plantation, using FAO land evaluation models (modified to suit Herois de Caxito conditions and GIS. Calculations of the radiationthermal production potential (RPP, land production potential (LPP, irrigation suitability index, and evaluation of the irrigation water quality are done. The water-limited production potential (WPP is found equal to the RPP, because water needs were fully met under irrigation. Maps showing the spatial distribution of the LPP and the suitability for irrigation are generated. The matching of irrigation and fertility indices has shown that, about 40% of the soils with good fertility for sugarcane production present low suitability for irrigation, the main limitations being the very fine texture and the drainage. The available surface water at Herois de Caxito (Dande river is of very good quality for irrigation of sugarcane.

  19. From Suitable Weak Solutions to Entropy Viscosity

    KAUST Repository

    Guermond, Jean-Luc; Pasquetti, Richard; Popov, Bojan

    2010-01-01

    This paper focuses on the notion of suitable weak solutions for the three-dimensional incompressible Navier-Stokes equations and discusses the relevance of this notion to Computational Fluid Dynamics. The purpose of the paper is twofold (i

  20. Obtaining shale oil suitable for lighting

    Energy Technology Data Exchange (ETDEWEB)

    Giraudel, M

    1851-11-12

    Treats with sulphuric acid and then with soda, obtaining 57 per cent of products suitable for lighting in place of the usual 35 to 40 per cent as obtained by present processes. The product has a less disagreeable odor.

  1. Using Machine Learning for Land Suitability Classification

    African Journals Online (AJOL)

    User

    West African Journal of Applied Ecology, vol. ... evidence for the utility of machine learning methods in land suitability classification especially MCS methods. ... Artificial intelligence tools. ..... Numerical values of index for the various classes.

  2. Exome Sequencing Identifies a Novel LMNA Splice-Site Mutation and Multigenic Heterozygosity of Potential Modifiers in a Family with Sick Sinus Syndrome, Dilated Cardiomyopathy, and Sudden Cardiac Death.

    Directory of Open Access Journals (Sweden)

    Michael V Zaragoza

    Full Text Available The goals are to understand the primary genetic mechanisms that cause Sick Sinus Syndrome and to identify potential modifiers that may result in intrafamilial variability within a multigenerational family. The proband is a 63-year-old male with a family history of individuals (>10 with sinus node dysfunction, ventricular arrhythmia, cardiomyopathy, heart failure, and sudden death. We used exome sequencing of a single individual to identify a novel LMNA mutation and demonstrated the importance of Sanger validation and family studies when evaluating candidates. After initial single-gene studies were negative, we conducted exome sequencing for the proband which produced 9 gigabases of sequencing data. Bioinformatics analysis showed 94% of the reads mapped to the reference and identified 128,563 unique variants with 108,795 (85% located in 16,319 genes of 19,056 target genes. We discovered multiple variants in known arrhythmia, cardiomyopathy, or ion channel associated genes that may serve as potential modifiers in disease expression. To identify candidate mutations, we focused on ~2,000 variants located in 237 genes of 283 known arrhythmia, cardiomyopathy, or ion channel associated genes. We filtered the candidates to 41 variants in 33 genes using zygosity, protein impact, database searches, and clinical association. Only 21 of 41 (51% variants were validated by Sanger sequencing. We selected nine confirmed variants with minor allele frequencies G, a novel heterozygous splice-site mutation as the primary mutation with rare or novel variants in HCN4, MYBPC3, PKP4, TMPO, TTN, DMPK and KCNJ10 as potential modifiers and a mechanism consistent with haploinsufficiency.

  3. Integrating Larval Dispersal, Permitting, and Logistical Factors Within a Validated Habitat Suitability Index for Oyster Restoration

    Directory of Open Access Journals (Sweden)

    Brandon J. Puckett

    2018-04-01

    Full Text Available Habitat suitability index (HSI models are increasingly used to guide ecological restoration. Successful restoration is a byproduct of several factors, including physical and biological processes, as well as permitting and logistical considerations. Rarely are factors from all of these categories included in HSI models, despite their combined relevance to common restoration goals such as population persistence. We developed a Geographic Information System (GIS-based HSI for restoring persistent high-relief subtidal oyster (Crassostrea virginica reefs protected from harvest (i.e., sanctuaries in Pamlico Sound, North Carolina, USA. Expert stakeholder input identified 17 factors to include in the HSI. Factors primarily represented physical (e.g., salinity and biological (e.g., larval dispersal processes relevant to oyster restoration, but also included several relevant permitting (e.g., presence of seagrasses and logistical (e.g., distance to restoration material stockpile sites considerations. We validated the model with multiple years of oyster density data from existing sanctuaries, and compared HSI output with distributions of oyster reefs from the late 1800's. Of the 17 factors included in the model, stakeholders identified four factors—salinity, larval export from existing oyster sanctuaries, larval import to existing sanctuaries, and dissolved oxygen—most critical to oyster sanctuary site selection. The HSI model provided a quantitative scale over which a vast water body (~6,000 km2 was narrowed down by 95% to a much smaller suite of optimal (top 1% HSI and suitable (top 5% HSI locations for oyster restoration. Optimal and suitable restoration locations were clustered in northeast and southwest Pamlico Sound. Oyster density in existing sanctuaries, normalized for time since reef restoration, was a positive exponential function of HSI, providing validation for the model. Only a small portion (10–20% of historical reef locations

  4. Suitability of Varicose Veins for Endovenous Treatments

    International Nuclear Information System (INIS)

    Goode, S. D.; Kuhan, G.; Altaf, N.; Simpson, R.; Beech, A.; Richards, T.; MacSweeney, S. T.; Braithwaite, B. D.

    2009-01-01

    The aim of the study was to assess the suitability of radiofrequency ablation (RFA), endovenous laser ablation (EVLA), and foam sclerotherapy (FS) for patients with symptomatic varicose veins (VVs). The study comprised 403 consecutive patients with symptomatic VVs. Data on 577 legs from 403 consecutive patients with symptomatic VVs were collected for the year 2006. Median patient age was 55 years (interquartile range 45-66), and 62% patients were women. A set of criteria based on duplex ultrasonography was used to select patients for each procedure. Great saphenous vein (GSV) reflux was present in 77% (446 of 577) of legs. Overall, 328 (73%) of the legs were suitable for at least one of the endovenous options. Of the 114 legs with recurrent GSV reflux disease, 83 (73%) were suitable to receive endovenous therapy. Patients with increasing age were less likely to be suitable for endovenous therapy (P = 0.03). Seventy-three percent of patients with VVs caused by GSV incompetence are suitable for endovenous therapy.

  5. A radioactive waste repository for Australia: methods for choosing the right site

    International Nuclear Information System (INIS)

    1992-01-01

    This study has developed and used an open and objective approach to site selection. A geographic information system was used to assemble continental-scale information. The information was classified according to suitability criteria and processed to show how the most suitable areas for locating Australia's radioactive waste repository can be identified. The test results show that different regions are identified when different selection criteria are used. The results in this discussion paper are indicative only and are intended to provide a focus for more detailed studies at regional and local levels following public comment on the criteria and methodology. The methodology for identifying a suitable site for a national repository for radioactive wastes will be re-applied with more detailed information to areas identified in this study and on the basis of public comments. 6 figs

  6. [Ecology suitability study of Ephedra intermedia].

    Science.gov (United States)

    Ma, Xiao-Hui; Lu, You-Yuan; Huang, De-Dong; Zhu, Tian-Tian; Lv, Pei-Lin; Jin, Ling

    2017-06-01

    The study aims at predicting ecological suitability of Ephedra intermedia in China by using maximum entropy Maxent model combined with GIS, and finding the main ecological factors affecting the distribution of E. intermedia suitability in appropriate growth area. Thirty-eight collected samples of E. intermedia and E. intermedia and 116 distribution information from CVH information using ArcGIS technology were analyzed. MaxEnt model was applied to forecast the E. intermedia in our country's ecology. E. intermedia MaxEnt ROC curve model training data and testing data sets the AUC value was 0.986 and 0.958, respectively, which were greater than 0.9, tending to be 1.The calculated E. intermedia habitat suitability by the model showed a high accuracy and credibility, which indicated that MaxEnt model could well predict the potential distribution area of E. intermedia in China. Copyright© by the Chinese Pharmaceutical Association.

  7. A tailing genome walking method suitable for genomes with high local GC content.

    Science.gov (United States)

    Liu, Taian; Fang, Yongxiang; Yao, Wenjuan; Guan, Qisai; Bai, Gang; Jing, Zhizhong

    2013-10-15

    The tailing genome walking strategies are simple and efficient. However, they sometimes can be restricted due to the low stringency of homo-oligomeric primers. Here we modified their conventional tailing step by adding polythymidine and polyguanine to the target single-stranded DNA (ssDNA). The tailed ssDNA was then amplified exponentially with a specific primer in the known region and a primer comprising 5' polycytosine and 3' polyadenosine. The successful application of this novel method for identifying integration sites mediated by φC31 integrase in goat genome indicates that the method is more suitable for genomes with high complexity and local GC content. Copyright © 2013 Elsevier Inc. All rights reserved.

  8. From Suitable Weak Solutions to Entropy Viscosity

    KAUST Repository

    Guermond, Jean-Luc

    2010-12-16

    This paper focuses on the notion of suitable weak solutions for the three-dimensional incompressible Navier-Stokes equations and discusses the relevance of this notion to Computational Fluid Dynamics. The purpose of the paper is twofold (i) to recall basic mathematical properties of the three-dimensional incompressible Navier-Stokes equations and to show how they might relate to LES (ii) to introduce an entropy viscosity technique based on the notion of suitable weak solution and to illustrate numerically this concept. © 2010 Springer Science+Business Media, LLC.

  9. High-level wastes: DOE names three sites for characterization

    International Nuclear Information System (INIS)

    Anon.

    1986-01-01

    DOE announced in May 1986 that there will be there site characterization studies made to determine suitability for a high-level radioactive waste repository. The studies will include several test drillings to the proposed disposal depths. Yucca Mountain, Nevada; Deaf Smith Country, Texas, and Hanford, Washington were identified as the study sites, and further studies for a second repository site in the East were postponed. The affected states all filed suits in federal circuit courts because they were given no advance warning of the announcement of their selection or the decision to suspend work on a second repository. Criticisms of the selection process include the narrowing or DOE options

  10. The use of computer simulation to assess the suitability of RWH ...

    African Journals Online (AJOL)

    ... which was designed to assess the suitability of RWH technology interventions for any new site. The simulation model is briefly described and typical examples of its use as a tool for agro-technology transfer are presented. The interface is user-friendly and the model itself is designed to work with readily available site data.

  11. Suitability of obstetric ultrasonographic parameters in determining ...

    African Journals Online (AJOL)

    Objective: A prospective study aimed at assessing the suitability of Biparietal Diameter (BPD), Femoral Length (FL), Transverse abdominal Diameter (TAD) and Composite value by ultrasonography, in determining foetal or gestational age derived by last menstrual period (LMP) in our environment was undertaken.

  12. SUITABILITY OF CARAMBOLA ( AVERRHOA CARAMBOLA ) FRUIT ...

    African Journals Online (AJOL)

    SUITABILITY OF CARAMBOLA ( AVERRHOA CARAMBOLA ) FRUIT JUICE AS A SUBSTRATE FOR WINE FERMENTATION. ... The analysis of the sugars showed glucose, fructose and sucrose as the predominant sugars present. Vitamin C content was substantially high (35 mg/100 g), but fat content was low (0.25%).

  13. Environmental assessment: Yucca Mountain site, Nevada research and development area, Nevada; Volume 3

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1986-05-01

    In February 1983, the US Department of Energy (DOE) identified the Yucca Mountain site in Nevada as one of nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. The site is in the Great Basin, which is one of five distinct geohydrologic settings considered for the first repository. To determine their suitability, the Yucca Mountain site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE`s General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. These evaluations were reported in draft environmental assessments (EAs), which were issued for public review and comment. After considering the comments received on the draft EAs, the DOE prepared the final EAs. On the basis of the evaluations reported in this EA, the DOE has found that the Yucca Mountain site is not disqualified under the guidelines. The DOE has also found that it is suitable for site characterization because the evidence does not support a conclusion that the site will not be able to meet each of the qualifying conditions specified in the guidelines. On the basis of these findings, the DOE is nominating the Yucca Mountain site as one of five sites suitable for characterization.

  14. Environmental assessment: Yucca Mountain site, Nevada research and development area, Nevada; Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1986-05-01

    In February 1983, the US Department of Energy (DOE) identified the Yucca Mountain site in Nevada as one of nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high- level radioactive waste. The site is in the Great Basin, which is one of five distinct geohydrologic settings considered for the first repository. To determine their suitability, the Yucca Mountain site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE`s General Guideline for the Recommendation of Sites for the Nuclear Waste Repositories. These evaluations were reported in draft environmental assessments (EA), which were issued for public review and comment. After considering the comments received on the draft EAs, the DOE prepared the final EAs. On the basis of the evaluations reported in this EA, the DOE found that the Yucca Mountain site is not disqualified under the guidelines. The DOE has also found that it is suitable for site characterization because the evidence does not support a conclusion that the site will not be able to meet each of the qualifying conditions specified in the guidelines. On the basis of these findings, the DOE is nominating the Yucca Mountain site as of five sites suitable for characterization.

  15. Environmental assessment: Yucca Mountain Site, Nevada Research and Development Area, Nevada; Volume 2

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1986-05-01

    In February 1983, the US Department of Energy (DOE) identified the Yucca Mountain site in Nevada as one of nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. The site is in the Great Basin, which is one of five distinct geohydrologic settings considered for the first repository. To determine their suitability, the Yucca Mountain site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE`s General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. These evaluations were reported in draft environmental assessments (EAs), which were issued for public review and comment. After considering the comments received on the draft EAs, the DOE prepared the final EAs. On the basis of the evaluations reported in this EA, the DOE has found that the Yucca Mountain site is not disqualified under the guidelines. The DOE has also found that is is suitable for site characterization because the evidence does not support a conclusion that the site will not be able to meet each of the qualifying conditions specified in the guidelines. On the basis of these findings, the DOE is nominating the Yucca Mountain site as one of five sites suitable for characterization.

  16. Environmental assessment: Yucca Mountain site, Nevada research and development area, Nevada

    International Nuclear Information System (INIS)

    1986-05-01

    In February 1983, the US Department of Energy (DOE) identified the Yucca Mountain site in Nevada as one of nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. The site is in the Great Basin, which is one of five distinct geohydrologic settings considered for the first repository. To determine their suitability, the Yucca Mountain site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. These evaluations were reported in draft environmental assessments (EAs), which were issued for public review and comment. After considering the comments received on the draft EAs, the DOE prepared the final EAs. On the basis of the evaluations reported in this EA, the DOE has found that the Yucca Mountain site is not disqualified under the guidelines. The DOE has also found that it is suitable for site characterization because the evidence does not support a conclusion that the site will not be able to meet each of the qualifying conditions specified in the guidelines. On the basis of these findings, the DOE is nominating the Yucca Mountain site as one of five sites suitable for characterization

  17. Environmental assessment: Yucca Mountain site, Nevada research and development area, Nevada

    International Nuclear Information System (INIS)

    1986-05-01

    In February 1983, the US Department of Energy (DOE) identified the Yucca Mountain site in Nevada as one of nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high- level radioactive waste. The site is in the Great Basin, which is one of five distinct geohydrologic settings considered for the first repository. To determine their suitability, the Yucca Mountain site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guideline for the Recommendation of Sites for the Nuclear Waste Repositories. These evaluations were reported in draft environmental assessments (EA), which were issued for public review and comment. After considering the comments received on the draft EAs, the DOE prepared the final EAs. On the basis of the evaluations reported in this EA, the DOE found that the Yucca Mountain site is not disqualified under the guidelines. The DOE has also found that it is suitable for site characterization because the evidence does not support a conclusion that the site will not be able to meet each of the qualifying conditions specified in the guidelines. On the basis of these findings, the DOE is nominating the Yucca Mountain site as of five sites suitable for characterization

  18. Environmental assessment: Yucca Mountain Site, Nevada Research and Development Area, Nevada

    International Nuclear Information System (INIS)

    1986-05-01

    In February 1983, the US Department of Energy (DOE) identified the Yucca Mountain site in Nevada as one of nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. The site is in the Great Basin, which is one of five distinct geohydrologic settings considered for the first repository. To determine their suitability, the Yucca Mountain site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. These evaluations were reported in draft environmental assessments (EAs), which were issued for public review and comment. After considering the comments received on the draft EAs, the DOE prepared the final EAs. On the basis of the evaluations reported in this EA, the DOE has found that the Yucca Mountain site is not disqualified under the guidelines. The DOE has also found that is is suitable for site characterization because the evidence does not support a conclusion that the site will not be able to meet each of the qualifying conditions specified in the guidelines. On the basis of these findings, the DOE is nominating the Yucca Mountain site as one of five sites suitable for characterization

  19. Using environmental niche modeling to find suitable habitats for the Hard-ground Barasingha in Madhya Pradesh, India

    Directory of Open Access Journals (Sweden)

    C. P. Singh

    2015-09-01

    Full Text Available The subspecies of Swamp Deer, the Hard-ground Barasingha (Rucervus duvaucelii branderi Pocock, is presently found only in Kanha Tiger Reserve (KTR in Madhya Pradesh, India. This subspecies is highly vulnerable to extinction, and reintroduction in suitable sites is the need of the hour.  Environmental niche models (GARP, SVM, ED, CSM aimed at providing a detailed prediction of species distribution by relating presence of species to 19 bioclimatic indices were developed, using swamp deer occurrence records in KTR. The predictions were appropriately weighted with the prevailing LU/LC classes to identify suitable habitats in Madhya Pradesh, India. The result shows that the southern region of Madhya Pradesh is suitable for the sustenance of Barasingha with varying degrees of habitability. Vicarious validation shows that most of these forest areas were the same as that of historical records dating back to 50 years. However, land use maps can help identify areas where this subspecies can be reintroduced. 

  20. Epibenthic Assessment of a Renewable Tidal Energy Site

    Directory of Open Access Journals (Sweden)

    Emma V. Sheehan

    2013-01-01

    Full Text Available Concern over global climate change as a result of fossil fuel use has resulted in energy production from renewable sources. Marine renewable energy devices provide clean electricity but can also cause physical disturbance to the local environment. There is a considerable paucity of ecological data at potential marine renewable energy sites that is needed to assess potential future impacts and allow optimal siting of devices. Here, we provide a baseline benthic survey for the Big Russel in Guernsey, UK, a potential site for tidal energy development. To assess the suitability of proposed sites for marine renewable energy in the Big Russel and to identify potential control sites, we compared species assemblages and habitat types. This baseline survey can be used to select control habitats to compare and monitor the benthic communities after installation of the device and contribute towards the optimal siting of any future installation.

  1. Integrating knowledge-based multi-criteria evaluation techniques with GIS for landfill site selection: A case study using AHP

    Directory of Open Access Journals (Sweden)

    Fagbohun B.J.

    2016-09-01

    Full Text Available A major challenge in most growing urban areas of developing countries, without a pre-existing land use plan is the sustainable and efficient management of solid wastes. Siting a landfill is a complicated task because of several environmental regulations. This challenge gives birth to the need to develop efficient strategies for the selection of proper waste disposal sites in accordance with all existing environmental regulations. This paper presents a knowledge-based multi-criteria decision analysis using GIS for the selection of suitable landfill site in Ado-Ekiti, Nigeria. In order to identify suitable sites for landfill, seven factors - land use/cover, geology, river, soil, slope, lineament and roads - were taken into consideration. Each factor was classified and ranked based on prior knowledge about the area and existing guidelines. Weights for each factor were determined through pair-wise comparison using Saaty’s 9 point scale and AHP. The integration of factors according to their weights using weighted index overlay analysis revealed that 39.23 km2 within the area was suitable to site a landfill. The resulting suitable area was classified as high suitability covering 6.47 km2 (16.49%, moderate suitability 25.48 km2 (64.95% and low suitability 7.28 km2 (18.56% based on their overall weights.

  2. Re-establishing the pecking order: Niche models reliably predict suitable habitats for the reintroduction of red-billed oxpeckers.

    Science.gov (United States)

    Kalle, Riddhika; Combrink, Leigh; Ramesh, Tharmalingam; Downs, Colleen T

    2017-03-01

    Distributions of avian mutualists are affected by changes in biotic interactions and environmental conditions driven directly/indirectly by human actions. The range contraction of red-billed oxpeckers ( Buphagus erythrorhynchus ) in South Africa is partly a result of the widespread use of acaracides (i.e., mainly cattle dips), toxic to both ticks and oxpeckers. We predicted the habitat suitability of red-billed oxpeckers in South Africa using ensemble models to assist the ongoing reintroduction efforts and to identify new reintroduction sites for population recovery. The distribution of red-billed oxpeckers was influenced by moderate to high tree cover, woodland habitats, and starling density (a proxy for cavity-nesting birds) with regard to nest-site characteristics. Consumable resources (host and tick density), bioclimate, surface water body density, and proximity to protected areas were other influential predictors. Our models estimated 42,576.88-98,506.98 km 2 of highly suitable habitat (0.5-1) covering the majority of Limpopo, Mpumalanga, North West, a substantial portion of northern KwaZulu-Natal (KZN) and the Gauteng Province. Niche models reliably predicted suitable habitat in 40%-61% of the reintroduction sites where breeding is currently successful. Ensemble, boosted regression trees and generalized additive models predicted few suitable areas in the Eastern Cape and south of KZN that are part of the historic range. A few southern areas in the Northern Cape, outside the historic range, also had suitable sites predicted. Our models are a promising decision support tool for guiding reintroduction programs at macroscales. Apart from active reintroductions, conservation programs should encourage farmers and/or landowners to use oxpecker-compatible agrochemicals and set up adequate nest boxes to facilitate the population recovery of the red-billed oxpecker, particularly in human-modified landscapes. To ensure long-term conservation success, we suggest that

  3. Readability, complexity, and suitability analysis of online lymphedema resources.

    Science.gov (United States)

    Tran, Bao Ngoc N; Singh, Mansher; Lee, Bernard T; Rudd, Rima; Singhal, Dhruv

    2017-06-01

    Over 72% of Americans use online health information to assist in health care decision-making. Previous studies of lymphedema literature have focused only on reading level of patient-oriented materials online. Findings indicate they are too advanced for most patients to comprehend. This, more comprehensive study, expands the previous analysis to include critical elements of health materials beyond readability using assessment tools to report on the complexity and density of data as well as text design, vocabulary, and organization. The top 10 highest ranked websites on lymphedema were identified using the most popular search engine (Google). Website content was analyzed for readability, complexity, and suitability using Simple Measure of Gobbledygook, PMOSE/iKIRSCH, and Suitability Assessment of Materials (SAM), respectively. PMOSE/iKIRSCH and SAM were performed by two independent raters. Fleiss' kappa score was calculated to ensure inter-rater reliability. Online lymphedema literature had a reading grade level of 14.0 (SMOG). Overall complexity score was 6.7 (PMOSE/iKIRSCH) corresponding to "low" complexity and requiring a 8th-12th grade education. Fleiss' kappa score was 80% (P = 0.04, "substantial" agreement). Overall suitability score was 45% (SAM) correlating to the lowest level of "adequate" suitability. Fleiss' kappa score was 76% (P = 0.06, "substantial" agreement). Online resources for lymphedema are above the recommended levels for readability and complexity. The suitability level is barely adequate for the intended audience. Overall, these materials are too sophisticated for the average American adult, whose literacy skills are well documented. Further efforts to revise these materials are needed to improve patient comprehension and understanding. Copyright © 2017 Elsevier Inc. All rights reserved.

  4. Land Suitability and Insurance Premiums: A GIS-based Multicriteria Analysis Approach for Sustainable Rice Production

    Directory of Open Access Journals (Sweden)

    Md Monjurul Islam

    2018-05-01

    Full Text Available The purpose of this research is to develop a land suitability model for rice production based on suitability levels and to propose insurance premiums to obtain maximum returns based on the harvest index and subsidy dependence factor for the marginal and moderately suitable lands in the northern part of Bangladesh. A multicriteria analysis was undertaken and a rice land suitability map was developed using geographical information system and analytical hierarchy process. The analysis identified that 22.74% of the area was highly suitable, while 14.86% was marginally suitable, and 28.54% was moderately suitable for rice production. However, 32.67% of the area, which was occupied by water bodies, rivers, forests, and settlements, is permanently not suitable; 1.19% is presently not suitable. To motivate low-quality land owners to produce rice, there is no alternative but to provide protection through crop insurance. We suggest producing rice up to marginally suitable lands to obtain support from insurance. The minimum coverage is marginal coverage (70% to cover the production costs, while the maximum coverage is high coverage (90% to enable a maximum return. This new crop insurance model, based on land suitability can be a rational support for owners of different quality land to increase production.

  5. Transferability of habitat suitability criteria for fishes in warmwater streams

    Science.gov (United States)

    Freeman, Mary C.; Bowen, Z.H.; Crance, J.H.

    1997-01-01

    We developed habitat suitability criteria and tested their transferability for nine fishes inhabiting unregulated Piedmont and Coastal Plain streams in Alabama. Cr iteria for optimal habitat were defined as ranges of depth, velocity, substrate type and cover type for which a species' suitability index (proportional abundance divided by proportional habitat availability, scaled from 0 to 1) equalled or exceeded 0.4. We evaluated the transferability of criteria between study sites by testing the null hypothesis that species occurrence in a sample was independent of whether or not the sample was taken in optimal habitat. We also tested criteria transference to a large, flow-regulated river sampled during low flow periods. Depth, velocity and most substrate criteria developed for the bronze darter Percina palmaris successfully transferred between unregulated streams and to the flow-regulated river samples. All criteria developed for a pair of closely related, allopatric darter species, Etheostoma chuckwachattee and E. jordani, transferred sucessfully when applied between species (in the unregulated sites) and to the regulated river samples. In contrast, criteria for the Alabama shiner Cyprinella callistia failed nearly all tests of transferability. Criteria for E. stigmaeum, P. nigrofasciata, an undescribed Percina species, and a pair of related, allopatric Cyprinella species transferred inconsistently. The species with good criteria transference had high suitability indices for shallow depths, fast current velocities and coarse substrates, characteristic of riffle species. We suggest that microhabitat criteria for riffle fishes are more likely to provide a transferable measure of habitat quality than criteria for fishes that, although restricted to fluvial habitats, commonly occupy a variety of pool and riffle habitats.

  6. Suitability of commercial transport for a shift to electric mobility

    DEFF Research Database (Denmark)

    Christensen, Linda; Kveiborg, Ole; Klauenberg, Jens

    2016-01-01

    the travel range of large vans is an important barrier for electrification due to the battery weight and the limitation of 3.5 tonnes gross vehicle weight for driving with a normal driving licence. The rule needs amendments for electric vehicles, as has been done in Germany. The paper recommends EU countries......This paper identifies commercial sectors suitable for a shift to electric mobility. The paper concludes that the construction and the health care service sectors are the most suitable for electric mobility because many vehicles are registered in these sectors and daily mileage is reasonably low....... They should be primary target groups of specific policy measures to promote the use of electric vehicles. Denmark has only had a few incentives to promote the use of commercial electric vehicles. Until now electric vehicles do generally not show economic benefits unless travel distance is high. However, today...

  7. A GIS methodology to identify potential corn stover collection locations

    Energy Technology Data Exchange (ETDEWEB)

    Haddad, Monica A. [Department of Community and Regional Planning, 583 College of Design, Iowa State University, Ames, IA 50011-3095 (United States); Anderson, Paul F. [Department of Landscape Architecture, 481 College of Design, Iowa State University, Ames, IA 50011 (United States); Department of Agronomy, 481 College of Design, Iowa State University, Ames, IA 50011 (United States)

    2008-12-15

    In this study, we use geographic information systems technology to identify potential locations in a Midwestern region for collection and storage of corn stover for use as biomass feedstock. Spatial location models are developed to identify potential collection sites along an existing railroad. Site suitability analysis is developed based on two main models: agronomic productivity potential and environmental costs. The analysis includes the following steps: (1) elaboration of site selection criteria; (2) identification of the study region and service area based on transportation network analysis; (3) reclassification of input spatial layers based on common scales; (4) overlaying the reclassified spatial layers with equal weights to generate the two main models; and (5) overlaying the main models using different weights. A pluralistic approach is adopted, presenting three different scenarios as alternatives for the potential locations. Our results suggest that there is a significant subset of potential sites that meet site selection criteria. Additional studies are needed to evaluate potential sites through field visits, assess economic and social costs, and estimate the proportion of corn producers willing to sell and transport corn stover to collection facilities. (author)

  8. Environmental Modeling, The Buffer Priority layers for Nitrogen Removal identify priority forest/grass buffer sites by subwatershed. Land use, hydrology, soil, and landscape characteristics were analyzed to rank opportunities with high nitrogen removal potential., Published in 2014, Smaller than 1:100000 scale, Maryland Department of Natural Resources (DNR).

    Data.gov (United States)

    NSGIC Education | GIS Inventory — Environmental Modeling dataset current as of 2014. The Buffer Priority layers for Nitrogen Removal identify priority forest/grass buffer sites by subwatershed. Land...

  9. Projective synchronization based on suitable separation

    International Nuclear Information System (INIS)

    Li Guohui; Xiong Chuan; Sun Xiaonan

    2007-01-01

    A new approach for constructing a projective-synchronized chaotic slave system is proposed in this paper. This method is based on suitable separation by decomposing the system as the linear part and the nonlinear one. From matrix measure theory, some simple but efficient criteria are derived for projective synchronization of chaotic system. Numerical simulations for the Lorenz system show that this control method works very well

  10. Nuclear site selection studies

    International Nuclear Information System (INIS)

    Gharib, A.; Zohoorian Izadpanah, A.A.; Iranmanesh, H.

    2000-01-01

    It is of special importance, especially from the nuclear safety viewpoint, to select suitable sites for different nuclear structures with the considered future activities. Site selection sometimes involves high costs not necessarily for merely selecting of site but for some preliminary measures to be taken so as the site may have the necessary characteristics. The more suitable the natural characteristics of the site for the considered project, the more successful and efficient the project, the lower the project costs and the longer the project operation period. If so, the project will cause the growth of public culture and sustainable socioeconomic development. This paper is the result of the conclusion of numerous massive reports of this activity in the preliminary phase based on theories, practices and the related safety principles on this ground as well as the application of data and information of the past and a glance to the future. The conception of need for a site for medium structures and nuclear research projects and how to perform this process are presented step by step here with a scientific approach to its selection during the investigations. In this study, it is practically described how the site is selected, by determining and defining the characteristics of research and nuclear projects with medium structures and also its fitting to the optimum site. The discovered sites typically involve the best advantages in technical and economic aspects and no particular contrast with the concerned structures

  11. The geology of some United Kingdom nuclear sites related to the disposal of low and medium level radioactive wastes

    International Nuclear Information System (INIS)

    Robins, N.S.

    1980-04-01

    The geological sequences beneath ten British nuclear sites are extrapolated from the available data. Formations that are potentially suitable hosts for low and medium level radioactive waste are identified and their relative merits assessed. Of the sites investigated, formations beneath five afford little or no potential, formations beneath a further three offer only moderate potential and sites underlain by the most favourable formations are at Dounreay and Harwell. (author)

  12. The geology of some United Kingdom nuclear sites related to the disposal of low and medium level radioactive wastes

    International Nuclear Information System (INIS)

    Robins, N.S.

    1980-06-01

    The geological sequences beneath a further twelve nuclear sites in Britain are predicted from available data. Formations that are potentially suitable hosts for low and medium-level radioactive waste are identified and their relative merits assessed. Of the sites investigated, formations beneath six afford little or no potential, formations beneath a further 4 offer only moderate potential and sites underlain by the most favourable formations are Dungeness and Hinkley Point. (author)

  13. Niche suitability affects development: skull asymmetry increases in less suitable areas.

    Directory of Open Access Journals (Sweden)

    Renan Maestri

    Full Text Available For conservation purposes, it is important to take into account the suitability of a species to particular habitats; this information may predict the long-term survival of a species. In this sense, morphological measures of developmental stress, such as fluctuating asymmetry, can be proxies for an individual's performance in different regions. In this study, we conducted tests to determine whether areas with different levels of suitability for a species (generated by ecological niche models were congruent with morphological markers that reflect environmental stress and morphological variance. We generated a Maxent niche model and compared the suitability assessments of several areas with the skull morphology data (fluctuating asymmetry and morphological disparity of populations of the Atlantic forest endemic to Brazil rodent Akodon cursor. Our analyses showed a significant negative relationship between suitability levels and fluctuating asymmetry levels, which indicates that in less suitable areas, the individuals experience numerous disturbances during skull ontogeny. We have not found an association between morphological variance and environmental suitability. As expected, these results suggest that in environments with a lower suitability, developmental stress is increased. Such information is helpful in the understanding of the species evolution and in the selection of priority areas for the conservation of species.

  14. Habitat suitability models of mountain ungulates: identifying potential areas for conservation

    Czech Academy of Sciences Publication Activity Database

    Paudel, Prakash K.; Hais, M.; Kindlmann, Pavel

    2015-01-01

    Roč. 54, apr (2015), s. 37 ISSN 1021-5506 R&D Projects: GA MŠk(CZ) LO1415; GA MŠk LC06073; GA ČR GB14-36098G Institutional support: RVO:67179843 Keywords : capricornis thar * habitat model * Midhills * Muntiacus muntjak * Naemorhedus goral * Nepal Subject RIV: EH - Ecology, Behaviour Impact factor: 0.885, year: 2015

  15. Siting regions for deep geological repositories. Why just here?

    International Nuclear Information System (INIS)

    Rieser, A.

    2009-09-01

    This report helps to the popularization of the Nagra works accomplished for the management and disposal of the radioactive wastes in Switzerland. The programme for management and disposal of the radioactive wastes are extensively determined by regulations. Protection of mankind and environment is the primary objective. The basic storage process is considered as having been solved. The question addressed in the report is where the facility has to be built; the site selection procedure includes five steps: 1) according to their type the wastes have to be allocated to two different repositories: for low- and intermediate-level wastes (L/ILW), and for high-level and alpha-toxic wastes (HLW); 2) the safety concept for both repositories and the requirements on the geology have to be determined; 3) large suitable geological-tectonic zones must be found where repositories could be built; 4) in these geological zones a suitable host rock has to be identified; 5) the most important spatial geological conditions of the host rock (minimum depth with respect to surface erosion, maximum depth in terms of engineering requirements, lateral extent) have to be identified. Based on these criteria, three suitable siting regions for a HLW repository were found in the North of Switzerland. The preferred host rock is Opalinus clay because of its very low permeability; it is therefore an excellent barrier against nuclide transport. In the three proposed siting regions, Opalinus clay is present in sufficient volumes at a suitable depth. For a L/ILW repository six different possible siting regions were identified, five in Northern Switzerland and one in Central Switzerland. In the three siting regions found for a possible HLW repository, it would also be possible to built a combined repository for both HLW and L/ILW wastes

  16. Transplantation assessment of degraded Posidonia oceanica habitats: site selection and long-term monitoring

    Directory of Open Access Journals (Sweden)

    M. PIRROTTA

    2014-09-01

    Full Text Available A model developed for Zostera marina was adapted and used to select suitable areas for Posidonia oceanica transplantation in the Gulf of Palermo, where recent rehabilitation programmes have reduced human pressure. This model consists of three steps: (1 habitat selection, by calculation of the Preliminary Transplant Suitability Index (PTSI; (2 field assessments and test-transplanting, to evaluate the site suitability and to estimate the effects of tearing on transplant units (about 50%; (3 identification of suitable restoration sites, by calculation of the Transplant Suitability Index (TSI. A new parameter was added to the literature model: the number of grids detached, which is linked to factors (hydrodynamic regime, anchoring, fishing that have a potentially great effect on the final outcome of the transplant. Only one site (TSI = 16 in the Gulf of Palermo was indicated as potentially suitable for restoration with P. oceanica. In this site, a transplant of 40 m2 was implemented. From 2008 to 2014, transplant effectiveness was evaluated in terms of establishment, detachment and mortality of cuttings and shoot density. The long-term monitoring (6 years allowed us to detect changes in the structural conditions of the transplanted meadow and to identify the possible turning point in P. oceanica recovery (2 years after transplanting. Moreover, 6 years after transplantation the P. oceanica meadow has exceeded the transplant shoot density of about 16%, with a mean and a maximum value of 11.6 and 17 shoots per cutting, respectively.

  17. Suitability Analysis For Scuba Diving To Develop Marine Tourism At Saebus Island, East Java, Indonesia

    Science.gov (United States)

    Wijaya, Putranto; Putra, Tri; Hidayat, Fatra; Levraeni, Chandra; Rizmaadi, Mada; Ambariyanto, Ambariyanto

    2018-02-01

    Indonesian government currently has policies to improve the performance of the tourism sector, including marine tourism. One of the attractions of marine tourism is the coral ecosystem especially through scuba diving activities. The purpose of this study was to determine the suitability of the coral ecosystem on Saebus Island, East Java, to find appropriate locations for scuba diving activities. Purposive samplings were done around the island to determine four stations which will be assessed through suitability analysis. Tourism Suitability Index was used to assess all stations for scuba diving activities. The result showed that all four stations were categorized as very suitable with the score: 85%, 85%, 85% and 83%, respectively. Several aspects that need to be improved and anticipated for diving at all stations are coral coverage and water current. These results suggest that there are several spots around Saebus Island that are suitable for diving site, and can be promoted as marine tourism destination.

  18. Identification of land areas suitable for Fadama farming at Federal ...

    African Journals Online (AJOL)

    Fadama farming provides a platform for sustained crop cultivation during dry season. This research was directed towards identifying new land areas within the Federal University of Agriculture with the use of Geographical Information System (GIS). The few existing Fadama sites within the study area were searched and their ...

  19. Pseudo-random-number generators and the square site percolation threshold.

    Science.gov (United States)

    Lee, Michael J

    2008-09-01

    Selected pseudo-random-number generators are applied to a Monte Carlo study of the two-dimensional square-lattice site percolation model. A generator suitable for high precision calculations is identified from an application specific test of randomness. After extended computation and analysis, an ostensibly reliable value of p_{c}=0.59274598(4) is obtained for the percolation threshold.

  20. BLM Colorado Wild and Scenic Rivers Line Features (Suitable/Eligible)

    Data.gov (United States)

    Department of the Interior — KMZ File Format –- This line feature class represents the segments identified as eligible or suitable for Wild and Scenic River designation. These segments are part...

  1. The suitability of quality-of-life questionnaires for psoriasis research - A systematic literature review

    NARCIS (Netherlands)

    de Korte, John; Mombers, Femke M. C.; Sprangers, Mirjam A. G.; Bos, Jan D.

    2002-01-01

    Objective: To critically appraise the suitability of current quality-of-life (QOL) questionnaires for psoriasis research. Data Sources: Computerized searches of 5 bibliographic databases. Questionnaire Selection: Predefined criteria were used to identify QOL questionnaires in dermatologic studies.

  2. Are current psychometric tools suitable for measuring outcomes of diabetes education?

    DEFF Research Database (Denmark)

    Eigenmann, C. A.; Colagiuri, R.; Skinner, T. C.

    2009-01-01

    Aims To critically appraise the suitability, validity, reliability, feasibility and sensitivity to change of available psychometric tools for measuring the education outcomes identified in the (Australian) National Consensus on Outcomes and Indicators for Diabetes Patient Education. Methods Poten...

  3. Identifying Functional Neighborhoods within the Cell Nucleus: Proximity Analysis of Early S-Phase Replicating Chromatin Domains to Sites of Transcription, RNA Polymerase II, HP1γ, Matrin 3 and SAF-A

    Science.gov (United States)

    Malyavantham, Kishore S; Bhattacharya, Sambit; Barbeitos, Marcos; Mukherjee, Lopamudra; Xu, Jinhui; Fackelmayer, Frank O; Berezney, Ronald

    2009-01-01

    Higher order chromatin organization in concert with epigenetic regulation is a key process that determines gene expression at the global level. The organization of dynamic chromatin domains and their associated protein factors is intertwined with nuclear function to create higher levels of functional zones within the cell nucleus. As a step towards elucidating the organization and dynamics of these functional zones, we have investigated the spatial proximities among a constellation of functionally related sites that are found within euchromatic regions of the cell nucleus including: HP1γ, nascent transcript sites (TS), active DNA replicating sites in early S phase (PCNA) and RNA polymerase II sites. We report close associations among these different sites with proximity values specific for each combination. Analysis of matrin 3 and SAF-A sites demonstrates that these nuclear matrix proteins are highly proximal with the functionally related sites as well as to each other and display closely aligned and overlapping regions following application of the minimal spanning tree (MST) algorithm to visualize higher order network-like patterns. Our findings suggest that multiple factors within the nuclear microenvironment collectively form higher order combinatorial arrays of function. We propose a model for the organization of these functional neighborhoods which takes into account the proximity values of the individual sites and their spatial organization within the nuclear architecture. PMID:18618731

  4. Analysis of land suitability for urban development in Ahwaz County in southwestern Iran using fuzzy logic and analytic network process (ANP).

    Science.gov (United States)

    Malmir, Maryam; Zarkesh, Mir Masoud Kheirkhah; Monavari, Seyed Masoud; Jozi, Seyed Ali; Sharifi, Esmail

    2016-08-01

    The ever-increasing development of cities due to population growth and migration has led to unplanned constructions and great changes in urban spatial structure, especially the physical development of cities in unsuitable places, which requires conscious guidance and fundamental organization. It is therefore necessary to identify suitable sites for future development of cities and prevent urban sprawl as one of the main concerns of urban managers and planners. In this study, to determine the suitable sites for urban development in the county of Ahwaz, the effective biophysical and socioeconomic criteria (including 27 sub-criteria) were initially determined based on literature review and interviews with certified experts. In the next step, a database of criteria and sub-criteria was prepared. Standardization of values and unification of scales in map layers were done using fuzzy logic. The criteria and sub-criteria were weighted by analytic network process (ANP) in the Super Decision software. Next, the map layers were overlaid using weighted linear combination (WLC) in the GIS software. According to the research findings, the final land suitability map was prepared with five suitability classes of very high (5.86 %), high (31.93 %), medium (38.61 %), low (17.65 %), and very low (5.95 %). Also, in terms of spatial distribution, suitable lands for urban development are mainly located in the central and southern parts of the Ahwaz County. It is expected that integration of fuzzy logic and ANP model will provide a better decision support tool compared with other models. The developed model can also be used in the land suitability analysis of other cities.

  5. Selection criteria for a radioactive waste disposal site in the Republic of South Africa

    International Nuclear Information System (INIS)

    Toens, P.D.; Hambleton-Jones, B.B.

    1986-01-01

    A program commenced in 1978 to select a suitable site for the disposal of nuclear waste in South Africa. This entailed the examination of a variety of socio-economic and earthscience related parameters over large parts of South Africa. The site selection program, for which the Geology Department of the Atomic Energy Corporation of South Africa Ltd (AEC) (previously the Nuclear Development Corporation (NUCOR)) accepted responsibility, commenced with an initial screening phase and led to the identification of potentially suitable areas by mid 1980. A site suitability phase involving regional, and subsequently detailed socio-economic, geological, geohydrological and geophysical studies in the areas identified by the screening phase was completed in December 1982. As a result of very positive indications that the district of Namaqualand was the most suitable candidate area it was possible, after further detailed investigations, to identify and purchase a site judged to be suitable for the disposal of low- and intermediate-level waste by February 1983. The area acquired measures some 10 000ha in extent and is situated 100km southeast of Springbok in the northwestern Cape and 600km north of the Koeberg nuclear power station near Cape Town

  6. Restoration Plan for Degraded Forest in The Democratic People’s Republic of Korea Considering Suitable Tree Species and Spatial Distribution

    Directory of Open Access Journals (Sweden)

    Sle-gee Lee

    2018-03-01

    Full Text Available The ecosystem across the Democratic People’s Republic of Korea (DPRK is threatened by deforestation. However, there is very little attention being given to government efforts for afforestation and rehabilitation plan. The most significant barriers to addressing this problem are technique limitations, availability of information, and lack of a stepwise forest management plan. This study identifies spatially suitable tree species, and establishes a stepwise restoration plan to support decision making for restoring degraded forest in the DPRK throughout a suitable restoration map. First off, target species were chosen from reference data, and spatial distribution maps for each tree species were prepared based on social needs as well as natural conditions in the DPRK. The suitable restoration map was calculated by two priorities in a weighting method; suitable priority, and distributional clustering level. Finally, the 23 afforestation species were selected for the suitable restoration map, including 11 coniferous and 12 deciduous tree species. We introduced a stepwise afforestation/restoration plan of degraded forest in the DPRK; general (long-term, detailed (medium-term, implementation (short-term plans. Maps with different spatial resolutions were prepared for each of the plans. A restoration map with 12.5 km spatial resolution can be used for the general plan at the national level, and maps with 5 km and 1 km spatial resolutions can be used for detailed plan at the local level and implementation plan at the site level, respectively.

  7. Superfund and Toxic Release Inventory Sites - MDC_ContaminatedSite

    Data.gov (United States)

    NSGIC Local Govt | GIS Inventory — A point feature class of open DERM Contaminated sites - see phase code for status of site. Contaminated sites identifies properties where environmental contamination...

  8. Threshold Assessment: Definition of Acceptable Sites as Part of Site Selection for the Japanese HLW Program

    International Nuclear Information System (INIS)

    McKenna, S.A.; Wakasugi, Keiichiro; Webb, E.K.; Makino, Hitoshi; Ishihara, Yoshinao; Ijiri, Yuji; Sawada, Atsushi; Baba, Tomoko; Ishiguro, Katsuhiko; Umeki, Hiroyuki

    2000-01-01

    For the last ten years, the Japanese High-Level Nuclear Waste (HLW) repository program has focused on assessing the feasibility of a basic repository concept, which resulted in the recently published H12 Report. As Japan enters the implementation phase, a new organization must identify, screen and choose potential repository sites. Thus, a rapid mechanism for determining the likelihood of site suitability is critical. The threshold approach, described here, is a simple mechanism for defining the likelihood that a site is suitable given estimates of several critical parameters. We rely on the results of a companion paper, which described a probabilistic performance assessment simulation of the HLW reference case in the H12 report. The most critical two or three input parameters are plotted against each other and treated as spatial variables. Geostatistics is used to interpret the spatial correlation, which in turn is used to simulate multiple realizations of the parameter value maps. By combining an array of realizations, we can look at the probability that a given site, as represented by estimates of this combination of parameters, would be good host for a repository site

  9. Site descriptions for preliminary radiological assessments of low-level waste repositories

    International Nuclear Information System (INIS)

    Burgess, W.E.; Jones, C.H.; Sumerling, T.J.; Ashton, J.

    1988-07-01

    The environmental contexts of four sites, previously under investigation by UK Nirex Ltd. as potential locations for low-level waste disposal facilities, are described. Information on geographical setting, climate, surface hydrology, land use, agriculture, fisheries, geology and hydrogeology is presented. The geological and hydrogeological data are interpreted with the support of deterministic modelling of groundwater conditions. The routes by which radionuclides may migrate from the site are identified and reduced to 1D statistical descriptions suitable for use in probabilistic risk assessments. Additional data required to improve the assessment of the performance of the site are identified. (author)

  10. Selection of suitable NDT methods for building inspection

    Science.gov (United States)

    Pauzi Ismail, Mohamad

    2017-11-01

    Construction of modern structures requires good quality concrete with adequate strength and durability. Several accidents occurred in the civil constructions and were reported in the media. Such accidents were due to poor workmanship and lack of systematic monitoring during the constructions. In addition, water leaking and cracking in residential houses was commonly reported too. Based on these facts, monitoring the quality of concrete in structures is becoming more and more important subject. This paper describes major Non-destructive Testing (NDT) methods for evaluating structural integrity of concrete building. Some interesting findings during actual NDT inspections on site are presented. The NDT methods used are explained, compared and discussed. The suitable methods are suggested as minimum NDT methods to cover parameters required in the inspection.

  11. Open-field test site

    Science.gov (United States)

    Gyoda, Koichi; Shinozuka, Takashi

    1995-06-01

    An open-field test site with measurement equipment, a turn table, antenna positioners, and measurement auxiliary equipment was remodelled at the CRL north-site. This paper introduces the configuration, specifications and characteristics of this new open-field test site. Measured 3-m and 10-m site attenuations are in good agreement with theoretical values, and this means that this site is suitable for using 3-m and 10-m method EMI/EMC measurements. The site is expected to be effective for antenna measurement, antenna calibration, and studies on EMI/EMC measurement methods.

  12. Habitat suitability and nest survival of white-headed woodpeckers in unburned forests of Oregon

    Science.gov (United States)

    Hollenbeck, Jeff P.; Saab, Victoria A.; Frenzel, Richard W.

    2011-01-01

    We evaluated habitat suitability and nest survival of breeding white-headed woodpeckers (Picoides albolarvatus) in unburned forests of central Oregon, USA. Daily nest-survival rate was positively related to maximum daily temperature during the nest interval and to density of large-diameter trees surrounding the nest tree. We developed a niche-based habitat suitability model (partitioned Mahalanobis distance) for nesting white-headed woodpeckers using remotely sensed data. Along with low elevation, high density of large trees, and low slope, our habitat suitability model suggested that interspersion–juxtaposition of low- and high-canopy cover ponderosa pine (Pinus ponderosa) patches was important for nest-site suitability. Cross-validation suggested the model performed adequately for management planning at a scale >1 ha. Evaluation of mapped habitat suitability index (HSI) suggested that the maximum predictive gain (HSI = 0.36), where the number of nest locations are maximized in the smallest proportion of the modeled landscape, provided an objective initial threshold for identification of suitable habitat. However, managers can choose the threshold HSI most appropriate for their purposes (e.g., locating regions of low–moderate suitability that have potential for habitat restoration). Consequently, our habitat suitability model may be useful for managing dry coniferous forests for white-headed woodpeckers in central Oregon; however, model validation is necessary before our model could be applied to other locations.

  13. Monazite as a suitable actinide waste form

    Energy Technology Data Exchange (ETDEWEB)

    Schlenz, Hartmut; Heuser, Julia; Schmitz, Stephan; Bosbach, Dirk [Forschungszentrum Juelich GmbH (Germany). Inst. fuer Energie und Klimaforschung (IEK), Nukleare Entsorgung und Reaktorsicherheit (IEK-6); Neumann, Andreas [Forschungszentrum Juelich GmbH (Germany). Inst. fuer Energie und Klimaforschung (IEK), Nukleare Entsorgung und Reaktorsicherheit (IEK-6); RWTH Aachen Univ. (Germany). Inst. for Crystallography

    2013-03-01

    The conditioning of radioactive waste from nuclear power plants and in some countries even of weapons plutonium is an important issue for science and society. Therefore the research on appropriate matrices for the immobilization of fission products and actinides is of great interest. Beyond the widely used borosilicate glasses, ceramics are promising materials for the conditioning of actinides like U, Np, Pu, Am, and Cm. Monazite-type ceramics with general composition LnPO{sub 4} (Ln = La to Gd) and solid solutions of monazite with cheralite or huttonite represent important materials in this field. Monazite appears to be a promising candidate material, especially because of its outstanding properties regarding radiation resistance and chemical durability. This article summarizes the most recent results concerning the characterization of monazite and respective solid solutions and the study of their chemical, thermal, physical and structural properties. The aim is to demonstrate the suitability of monazite as a secure and reliable waste form for actinides. (orig.)

  14. The suitability of internal versus external successors

    DEFF Research Database (Denmark)

    Boyd, Britta; Royer, Susanne

    2012-01-01

    Understanding knowledge transfer in family firm succession is important for the survival of family firms. Previous research has begun to explore the suitability of internal versus external successor in family firms with regard to relevant knowledge types. This paper builds on the contingency model...... of family business succession in order to understand when family successors are preferred because of their family-specific experiential knowledge. A case study analysis from the German-Danish border region explores how a family firm has used internal successors for the last 12 successions. We argue...... that in industries where tacit knowledge forms the basis for competitive advantage, the use of internal successors can help family firms excel after a transition of power has occurred. Theoretical and practical implications are discussed to enhance the long-term perspective for family businesses....

  15. An assessment of the long term suitability of present and proposed methods for the management of uranium mill tailings

    International Nuclear Information System (INIS)

    1979-07-01

    Proposals for safe, long-term containment of conventional tailings include 1) storage under water, 2) storage in active, abandoned or specially created underground mines and, 3) storage in open pits, with subsequent flooding or covering with overburden. The underwater proposal can meet most of the requirements of long term containment; however, extensive study of existing tailings deposits in deep water locations will be needed. Underground mines cannot provide sufficient storage capacity, since the tailings bulk during mill operation can occupy twice the volume of the original ore. It is possible to reduce the hazard by reducing the radium and thorium content of the tailings. Proposals for such an undertaking include ore beneficiation with rejection of the relatively innocuous fraction, radium-thorium removal in the mill, and significant changes in both ore processing and treatment of tailings. It is concluded that surface-stored tailings are vulnerable over the long term to dispersion by leaching and water erosion, and that access to a tailings site cannot be prevented, while only a major climatic or seismic event could disturb tailings stored in suitable underwater or underground mine sites. The criteria for determining suitability for each method, however, will need to be identified, tested, and accepted through the normal process of modeling, pilot plant evaluation, monitoring and evaluation. (author)

  16. Land Suitability Assessment And Precision Farming Prospects For ...

    African Journals Online (AJOL)

    The soils on the farm were sampled and profiles classified using South African Binomial system of soil classification. The farm was divided into suitability classes of highly suitable (S1), suitable (S2), and unsuitable (N1), and permanently unsuitable (N2) classes. Maize-soybean suitability maps were produced based on soil ...

  17. Secondary plant succession on disturbed sites at Yucca Mountain, Nevada

    International Nuclear Information System (INIS)

    Angerer, J.P.; Ostler, W.K.; Gabbert, W.D.; Schultz, B.W.

    1994-12-01

    This report presents the results of a study of secondary plant succession on disturbed sites created during initial site investigations in the late 1970s and early 1980s at Yucca Mountain, NV. Specific study objectives were to determine the rate and success of secondary plant succession, identify plant species found in disturbances that may be suitable for site-specific reclamation, and to identify environmental variables that influence succession on disturbed sites. During 1991 and 1992, fifty seven disturbed sites were located. Vegetation parameters, disturbance characteristics and environmental variables were measured at each site. Disturbed site vegetation parameters were compared to that of undisturbed sites to determine the status of disturbed site plant succession. Vegetation on disturbed sites, after an average of ten years, was different from undisturbed areas. Ambrosia dumosa, Chrysothamnus teretifolius, Hymenoclea salsola, Gutierrezia sarothrae, Atriplex confertifolia, Atriplex canescens, and Stephanomeria pauciflora were the most dominant species across all disturbed sites. With the exception of A. dumosa, these species were generally minor components of the undisturbed vegetation. Elevation, soil compaction, soil potassium, and amounts of sand and gravel in the soil were found to be significant environmental variables influencing the species composition and abundance of perennial plants on disturbed sites. The recovery rate for disturbed site secondary succession was estimated. Using a linear function (which would represent optimal conditions), the recovery rate for perennial plant cover, regardless of which species comprised the cover, was estimated to be 20 years. However, when a logarithmic function (which would represent probable conditions) was used, the recovery rate was estimated to be 845 years. Recommendations for future studies and site-specific reclamation of disturbances are presented

  18. Secondary plant succession on disturbed sites at Yucca Mountain, Nevada

    Energy Technology Data Exchange (ETDEWEB)

    Angerer, J.P.; Ostler, W.K.; Gabbert, W.D.; Schultz, B.W.

    1994-12-01

    This report presents the results of a study of secondary plant succession on disturbed sites created during initial site investigations in the late 1970s and early 1980s at Yucca Mountain, NV. Specific study objectives were to determine the rate and success of secondary plant succession, identify plant species found in disturbances that may be suitable for site-specific reclamation, and to identify environmental variables that influence succession on disturbed sites. During 1991 and 1992, fifty seven disturbed sites were located. Vegetation parameters, disturbance characteristics and environmental variables were measured at each site. Disturbed site vegetation parameters were compared to that of undisturbed sites to determine the status of disturbed site plant succession. Vegetation on disturbed sites, after an average of ten years, was different from undisturbed areas. Ambrosia dumosa, Chrysothamnus teretifolius, Hymenoclea salsola, Gutierrezia sarothrae, Atriplex confertifolia, Atriplex canescens, and Stephanomeria pauciflora were the most dominant species across all disturbed sites. With the exception of A. dumosa, these species were generally minor components of the undisturbed vegetation. Elevation, soil compaction, soil potassium, and amounts of sand and gravel in the soil were found to be significant environmental variables influencing the species composition and abundance of perennial plants on disturbed sites. The recovery rate for disturbed site secondary succession was estimated. Using a linear function (which would represent optimal conditions), the recovery rate for perennial plant cover, regardless of which species comprised the cover, was estimated to be 20 years. However, when a logarithmic function (which would represent probable conditions) was used, the recovery rate was estimated to be 845 years. Recommendations for future studies and site-specific reclamation of disturbances are presented.

  19. Suitable long tendon technologies and practices

    CSIR Research Space (South Africa)

    Altounyan, P

    2001-10-01

    Full Text Available roofs in highly stressed areas. ? Few sites have written procedures for the correct installation of cable anchors and rely on the expertise and integrity of the contractors employed to install the systems. Contractors may not be fully conversant... post grouting of these highly engineered systems is relatively easy, lifting heavy tensioning jacks up to the roof can make the pretensioning operation arduous. Other less expensive systems offer strand UTS values of 55 to 60 tonnes and, with barrel...

  20. Site characterization plan:

    International Nuclear Information System (INIS)

    1988-01-01

    The Yucca Mountain site in Nevada is one of three candidate sites for the first geologic repository for radioactive waste. On May 28, 1986, it was recommended for detailed study in a program of site characterization. This site characterization plan (SCP) has been prepared in accordance with the requirements of the Nuclear Waste Policy Act to summarize the information collected to date about the geologic conditions at the site;to describe the conceptual designs for the repository and the waste package;and to present the plans for obtaining the geologic information necessary to demonstrate the suitability of the site for repository, to design the repository and the waste package, to prepare an environmental impact statement, and to obtain from the US Nuclear Regulatory Commission (NRC) an authorization to construct the repository. This introduction begins with a brief section on the process for siting and developing a repository, followed by a discussion of the pertinent legislation and regulations. A description of site characterization is presented next;it describes the facilities to be constructed for the site characterization program and explains the principal activities to be conducted during the program. Finally, the purpose, content, organizing principles, and organization of this site characterization plan are outlined, and compliance with applicable regulations is discussed

  1. Site characterization plan:

    International Nuclear Information System (INIS)

    1988-01-01

    The Yucca Mountain site in Nevada is one of three candidate sites for the first geologic repository for radioactive waste. On May 28, 1986, it was recommended for detailed study in a program of site characterization. This site characterization plan (SCP) has been prepared in acordance with the requirements of the Nuclear Waste Policy Act to summarize the information collected to date about the geologic conditions at the site;to describe the conceptual designs for the repository and the waste package and to present the plans for obtaining the geologic information necessary to demonstrate the suitability of the site for a repository, to design the repository and the waste package, to prepare an environmental impact statement, and to obtain from the US Nuclear Regulatory Commission (NRC) an authorization to construct the repository. This introduction begins with a brief section on the process for siting and eveloping a repository, followed by a discussion of the pertinent legislation and regulations. A description of site characterization is presented next;it describes the facilities to be constructed for the site characterization program and explains the principal activities to be conducted during the program. Finally, the purpose, content, organizing prinicples, and organization of this site characterization plan are outlined, and compliance with applicable regulations is discussed. 880 refs., 130 figs., 25 tabs

  2. Mid-Atlantic elasmobranchs: Suitable metal scouts?

    International Nuclear Information System (INIS)

    Torres, Paulo; Tristão da Cunha, Regina; Rodrigues, Armindo dos Santos

    2017-01-01

    Heavy metals are a hazard to marine fauna and human health. In this study we assess stable isotopes and metal content in Prionace glauca and Isurus oxyrinchus and analyse these results within and among other species and across regions and geographical areas. Also, we evaluate their suitability, together with Raja clavata and Galeorhinus galeus, as Mid-Atlantic bioindicators. Prionace glauca and I. oxyrinchus shared the same trophic level in a pelagic food web and did not present significant differences between genders or metals, except for As. Arsenic and Hg accumulated while Cd and Pb were not detected. One I. oxyrinchus presented Hg values above regulatory limits. A high Hg exposure was associated with I. oxyrinchus since its maximum weekly intake was exceeded. Elasmobranchs can be used as metal sentinels, each presenting different key features which defines a good marine bioindicator, allowing long-term monitoring at different temporal and spatial scales. - Highlights: • We analysed P. glauca and I. oxyrinchus muscle from Mid-Atlantic. • We determined stable isotopes, trophic ecology and heavy metal content. • Results reflect bioaccumulation for As and Hg. • Oxyrinchus already presented Hg values above regulatory limits. • Mid-Atlantic elasmobranchs appear to be effective metal bioindicators.

  3. Selecting suitable enclosures for digitally printed materials

    International Nuclear Information System (INIS)

    Burge, D; Rima, L

    2010-01-01

    It cannot be assumed that storage enclosures considered safe for traditionally printed images and documents are suitable for modern, digitally printed materials. In this project, a large variety of digital print types were tested using a modified version of the ISO 18916 Imaging materials-Processed imaging materials-Photographic activity test for enclosure materials standard to assess the risk to digital prints by paper enclosures known to be inert or reactive with traditional photographic prints. The types of enclosures tested included buffered and non-buffered cotton papers, and groundwood paper. In addition, qualitative filter paper that had been wetted and dried with either an acidic or basic solution was also tested to determine the effects of enclosure pH on digitally printed materials. It was determined that, in general, digital prints tended to be less reactive with various enclosure types than traditional prints. Digital prints were most sensitive to paper that contained groundwood. The enclosure reactivity test results were then integrated with previous published work on the tendencies of various enclosure types to abrade, ferrotype, or block to digital prints in order to create a comprehensive set of recommendations for digital print storage enclosures.

  4. Quantitative validation of a habitat suitability index for oyster restoration

    Directory of Open Access Journals (Sweden)

    Seth eTheuerkauf

    2016-05-01

    Full Text Available Habitat suitability index (HSI models provide spatially explicit information on the capacity of a given habitat to support a species of interest, and their prevalence has increased dramatically in recent years. Despite caution that the reliability of HSIs must be validated using independent, quantitative data, most HSIs intended to inform terrestrial and marine species management remain unvalidated. Furthermore, of the eight HSI models developed for eastern oyster (Crassostrea virginica restoration and fishery production, none has been validated. Consequently, we developed, calibrated, and validated an HSI for the eastern oyster to identify optimal habitat for restoration in a tributary of Chesapeake Bay, the Great Wicomico River (GWR. The GWR harbors a high density, restored oyster population, and therefore serves as an excellent model system for assessing the validity of the HSI. The HSI was derived from GIS layers of bottom type, salinity, and water depth (surrogate for dissolved oxygen, and was tested using live adult oyster density data from a survey of high vertical relief reefs (HRR and low vertical relief reefs (LRR in the sanctuary network. Live adult oyster density was a statistically-significant sigmoid function of the HSI, which validates the HSI as a robust predictor of suitable oyster reef habitat for rehabilitation or restoration. In addition, HRR had on average 103-116 more adults m^−2 than LRR at a given level of the HSI. For HRR, HSI values ≥0.3 exceeded the accepted restoration target of 50 live adult oysters m^−2. For LRR, the HSI was generally able to predict live adult oyster densities that meet or exceed the target at HSI values ≥0.3. The HSI indicated that there remain large areas of suitable habitat for restoration in the GWR. This study provides a robust framework for HSI model development and validation, which can be refined and applied to other systems and previously developed HSIs to improve the efficacy of

  5. Environmental assessment, Deaf Smith County site, Texas

    Energy Technology Data Exchange (ETDEWEB)

    1986-05-01

    The Nuclear Waste Policy Act of 1982 (42 USC sections 10101-10226) requires the environmental assessment of a proposed site to include a statement of the basis for nominating a site as suitable for characterization. Volume 2 provides a detailed statement evaluating the site suitability of the Deaf Smith County Site under DOE siting guidelines, as well as a comparison of the Deaf Smith County Site to the other sites under consideration. The evaluation of the Deaf Smith County Site is based on the impacts associated with the reference repository design, but the evaluation will not change if based on the Mission Plan repository concept. The second part of this document compares the Deaf Smith County Site to Davis Canyon, Hanford, Richton Dome and Yucca Mountain. This comparison is required under DOE guidelines and is not intended to directly support subsequent recommendation of three sites for characterization as candidate sites. 259 refs., 29 figs., 66 refs. (MHB)

  6. Environmental assessment, Richton Dome site, Mississippi (US)

    Energy Technology Data Exchange (ETDEWEB)

    none,

    1986-05-01

    The Nuclear Waste Policy Act of 1982 (42 USC Sections 10101-10226) requires the environmental assessment of a potential site to include a statement of the basis for the nomination of a site as suitable for characterization. Volume 2 of this environmental assessment provides a detailed evaluation of the Richton Dome Site and its suitability as the site for a radioactive waste disposal facility under DOE siting guidelines, as well as a comparison of the Richton Dome site with other proposed sites. Evaluation of the Richton Dome site is based on the reference repository design, but the evaluation will not change if based on the Mission Plan repository concept. The comparative evaluation of proposed sites is required under DOE guidelines, but is not intended to directly support the subsequent recommendation of three sites for characterization as candidate sites. 428 refs., 24 figs., 62 tabs. (MHB)

  7. Environmental assessment, Richton Dome site, Mississippi

    International Nuclear Information System (INIS)

    1986-05-01

    The Nuclear Waste Policy Act of 1982 (42 USC Sections 10101-10226) requires the environmental assessment of a potential site to include a statement of the basis for the nomination of a site as suitable for characterization. Volume 2 of this environmental assessment provides a detailed evaluation of the Richton Dome Site and its suitability as the site for a radioactive waste disposal facility under DOE siting guidelines, as well as a comparison of the Richton Dome site with other proposed sites. Evaluation of the Richton Dome site is based on the reference repository design, but the evaluation will not change if based on the Mission Plan repository concept. The comparative evaluation of proposed sites is required under DOE guidelines, but is not intended to directly support the subsequent recommendation of three sites for characterization as candidate sites. 428 refs., 24 figs., 62 tabs

  8. Environmental assessment, Deaf Smith County site, Texas

    International Nuclear Information System (INIS)

    1986-05-01

    The Nuclear Waste Policy Act of 1982 (42 USC sections 10101-10226) requires the environmental assessment of a proposed site to include a statement of the basis for nominating a site as suitable for characterization. Volume 2 provides a detailed statement evaluating the site suitability of the Deaf Smith County Site under DOE siting guidelines, as well as a comparison of the Deaf Smith County Site to the other sites under consideration. The evaluation of the Deaf Smith County Site is based on the impacts associated with the reference repository design, but the evaluation will not change if based on the Mission Plan repository concept. The second part of this document compares the Deaf Smith County Site to Davis Canyon, Hanford, Richton Dome and Yucca Mountain. This comparison is required under DOE guidelines and is not intended to directly support subsequent recommendation of three sites for characterization as candidate sites. 259 refs., 29 figs., 66 refs

  9. 77 FR 71435 - Federal Property Suitable as Facilities To Assist the Homeless

    Science.gov (United States)

    2012-11-30

    ...--radar site, right-of-way Pennsylvania Old Marienville Compound 110 South Forest St. Marienville PA 16239...-story structure with 1,024 sq. ft. per floor for a total of 2,048 sq. ft.; structure type: Log Cabin... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5601-N-47] Federal Property Suitable as...

  10. Raster-based outranking method: a new approach for municipal solid waste landfill (MSW) siting.

    Science.gov (United States)

    Hamzeh, Mohamad; Abbaspour, Rahim Ali; Davalou, Romina

    2015-08-01

    MSW landfill siting is a complicated process because it requires integration of several factors. In this paper, geographic information system (GIS) and multiple criteria decision analysis (MCDA) were combined to handle the municipal solid waste (MSW) landfill siting. For this purpose, first, 16 input data layers were prepared in GIS environment. Then, the exclusionary lands were eliminated and potentially suitable areas for the MSW disposal were identified. These potentially suitable areas, in an innovative approach, were further examined by deploying Preference Ranking Organization Method for Enrichment Evaluations (PROMETHEE) II and analytic network process (ANP), which are two of the most recent MCDA methods, in order to determine land suitability for landfilling. PROMETHEE II was used to determine a complete ranking of the alternatives, while ANP was employed to quantify the subjective judgments of evaluators as criteria weights. The resulting land suitability was reported on a grading scale of 1-5 from 1 to 5, which is the least to the most suitable area, respectively. Finally, three optimal sites were selected by taking into consideration the local conditions of 15 sites, which were candidates for MSW landfilling. Research findings show that the raster-based method yields effective results.

  11. Sensitivity analysis of land unit suitability for conservation using a knowledge-based system.

    Science.gov (United States)

    Humphries, Hope C; Bourgeron, Patrick S; Reynolds, Keith M

    2010-08-01

    The availability of spatially continuous data layers can have a strong impact on selection of land units for conservation purposes. The suitability of ecological conditions for sustaining the targets of conservation is an important consideration in evaluating candidate conservation sites. We constructed two fuzzy logic-based knowledge bases to determine the conservation suitability of land units in the interior Columbia River basin using NetWeaver software in the Ecosystem Management Decision Support application framework. Our objective was to assess the sensitivity of suitability ratings, derived from evaluating the knowledge bases, to fuzzy logic function parameters and to the removal of data layers (land use condition, road density, disturbance regime change index, vegetation change index, land unit size, cover type size, and cover type change index). The amount and geographic distribution of suitable land polygons was most strongly altered by the removal of land use condition, road density, and land polygon size. Removal of land use condition changed suitability primarily on private or intensively-used public land. Removal of either road density or land polygon size most strongly affected suitability on higher-elevation US Forest Service land containing small-area biophysical environments. Data layers with the greatest influence differed in rank between the two knowledge bases. Our results reinforce the importance of including both biophysical and socio-economic attributes to determine the suitability of land units for conservation. The sensitivity tests provided information about knowledge base structuring and parameterization as well as prioritization for future data needs.

  12. Modeling mountain pine beetle habitat suitability within Sequoia National Park

    Science.gov (United States)

    Nguyen, Andrew

    Understanding significant changes in climate and their effects on timber resources can help forest managers make better decisions regarding the preservation of natural resources and land management. These changes may to alter natural ecosystems dependent on historical and current climate conditions. Increasing mountain pine beetle (MBP) outbreaks within the southern Sierra Nevada are the result of these alterations. This study better understands MPB behavior within Sequoia National Park (SNP) and model its current and future habitat distribution. Variables contributing to MPB spread are vegetation stress, soil moisture, temperature, precipitation, disturbance, and presence of Ponderosa (Pinus ponderosa) and Lodgepole (Pinus contorta) pine trees. These variables were obtained using various modeled, insitu, and remotely sensed sources. The generalized additive model (GAM) was used to calculate the statistical significance of each variable contributing to MPB spread and also created maps identifying habitat suitability. Results indicate vegetation stress and forest disturbance to be variables most indicative of MPB spread. Additionally, the model was able to detect habitat suitability of MPB with a 45% accuracy concluding that a geospatial driven modeling approach can be used to delineate potential MPB spread within SNP.

  13. Faecal corticosterone metabolite concentrations are not a good predictor of habitat suitability for common gartersnakes.

    Science.gov (United States)

    Halliday, William D; Gilmour, Kathleen M; Blouin-Demers, Gabriel

    2015-01-01

    Measuring habitat suitability is important in conservation and in wildlife management. Measuring the abundance or presence-absence of a species in various habitats is not sufficient to measure habitat suitability because these metrics can be poor predictors of population success. Therefore, having some measure of population success is essential in assessing habitat suitability, but estimating population success is difficult. Identifying suitable proxies for population success could thus be beneficial. We examined whether faecal corticosterone metabolite (fCM) concentrations could be used as a proxy for habitat suitability in common gartersnakes (Thamnophis sirtalis). We conducted a validation study and confirmed that fCM concentrations indeed reflect circulating corticosterone concentrations. We estimated abundance, reproductive output and growth rate of gartersnakes in field and in forest habitat and we also measured fCM concentrations of gartersnakes from these same habitats. Common gartersnakes were more abundant and had higher reproductive outputs and higher growth rates in field habitat than in forest habitat, but fCM concentrations did not differ between the same two habitats. Our results suggest either that fCM concentrations are not a useful metric of habitat suitability in common gartersnakes or that the difference in suitability between the two habitats was too small to induce changes in fCM concentrations. Incorporating fitness metrics in estimates of habitat suitability is important, but these metrics of fitness have to be sensitive enough to vary between habitats.

  14. Siting of near surface disposal facilities

    International Nuclear Information System (INIS)

    1994-01-01

    Radioactive waste is generated from the production of nuclear energy and from the use of radioactive materials in industrial applications, research and medicine. The importance of safe management of radioactive waste for the protection of human health and the environment has long been recognized and considerable experience has been gained in this field. The Radioactive Waste Safety Standards (RADWASS) programme is the IAEA's contribution to establishing and promoting, in a coherent and comprehensive manner, the basic safety philosophy for radioactive waste management and the steps necessary to ensure its implementation. The Safety Standards are supplemented by a number of Safety Guides and Safety Practices. This Safety Guide defines the site selection process and criteria for identifying suitable near surface disposal facilities for low and intermediate level solid wastes. Management of the siting process and data needed to apply the criteria are also specified. 4 refs

  15. Cell-based land use screening procedure for regional siting analysis

    International Nuclear Information System (INIS)

    Jalbert, J.S.; Dobson, J.E.

    1976-01-01

    An energy facility site-screening methodology which permits the land resource planner to identify candidate siting areas was developed. Through the use of spatial analysis procedures and computer graphics, a selection of candidate areas is obtained. Specific sites then may be selected from among candidate areas for environmental impact analysis. The computerized methodology utilizes a cell-based geographic information system for specifying the suitability of candidate areas for an energy facility. The criteria to be considered may be specified by the user and weighted in terms of importance. Three primary computer programs have been developed. These programs produce thematic maps, proximity calculations, and suitability calculations. Programs are written so as to be transferrable to regional planning or regulatory agencies to assist in rational and comprehensive power plant site identification and analysis

  16. Tsunami shelter in Padang city: Location suitability and management issue

    Science.gov (United States)

    Rita, Eva; Permata, Robby; Yonne, Hilma; Carlo, Nasfryzal

    2017-11-01

    The building of Temporary Evacuation Sites (TES/shelter) is an effort to minimize the vulnerability of the population who live in coastal city areas with high risk of tsunami. Padang city in Indonesia, one of the cities with high risk of tsunami, has built shelter in North Ulak Karang Village, North Padang Sub-district. The problems are the location of shelter does not meet the standard of population number, how to manage the shelter in normal condition (without disaster), and who will be responsible for the management of the shelter. The aim of the study is to learn the suitability of shelter location and the management of the shelter in normal condition as well as the expectation of the people who live near the shelter location. This research uses evaluative-descriptive method with the collection of secondary and primary data through structured interviews with 200 respondents in the area of shelter building. The result shows that the furthest location of the shelter is located at RW 03 with a distance of 1.3 kms which takes 12.15-24.30 minutes. It shows that the shelter location in Padang meets the requirement of FEMA P646. At normal condition, shelter can be used for sport and educational activities, as a center for socialisation and simulation of disaster and other activities. The management of the shelter is done together by government and stakeholders. The proposed management is by forming a team (organization) which involves Disaster Alert groups (KSB) and by making the Standard Operational Procedures (SOP) for their implementation. People expect that the number of shelter is added and the building of the shelter is based on the suitability of location, number of population and availability of land.

  17. Repository site characterization

    International Nuclear Information System (INIS)

    Voss, J.W.; Pentz, D.L.

    1987-01-01

    The characterization of candidate repository sites has a number of programmatic objectives. Principal among these is the acquisition of data: a) to determine the suitability of a site relative to the DOE repository siting guidelines, b) to support model development and calculations to determine the suitability of a site relative to the post closure criteria of the NRC and EPA, c) to support the design of a disposal system, including the waste package and the engineered barrier system, as well as the shafts and underground openings of the repository. In meeting the gaols of site characterization, the authors have an obligation to conduct their investigations within an appropriate budget and schedule. This mandates that a well-constructed and systematic plan for field investigations be developed. Such a plan must fully account for the mechanisms which will control the radiologic performance in the repository. The plan must also flexibly and dynamically respond to the results of each step of field investigation, responding to the spatial variability of earth as well as to enhanced understandings of the performance of the disposal system. Such a plan must ensure that sufficient data are available to support the necessary probabilistic calculations of performance. This paper explores the planning for field data acquisition with specific reference to requirements for demonstrations of the acceptable performance for disposal systems

  18. Development of site selection criteria for radioactive waste disposal in view of favourable geological settings in Germany

    International Nuclear Information System (INIS)

    Baltes, B.; Brewitz, W.

    2001-01-01

    In Germany it is intended to dispose of all types of radioactive waste in deep geological formations. Since the government has doubts regarding the suitability of the Gorleben site, further sites in different host rock formations have to be investigated. This investigation process has to be carried out with respect to technical suitability and safety as well as to public acceptance. A Committee has been established whose mandate is to develop a comprehensible procedure for the selection of sites for radioactive waste disposal in Germany. The Committee developed an iterative procedure which provides, besides the increase of transparency, the necessary flexibility in dealing with assessment results. The method is governed by geo-scientific and social-scientific criteria that are presented in this paper. 7 steps have been identified in the procedure: 1) exclusion of areas with obviously unfavourable conditions, 2) identification of areas with favourable geological settings, 3) exclusion of areas for socio-scientific reasons, 4) identification of regions with favourable conditions and ranking of regions, 5) identification of sites for further identification, 6) above-ground site investigation and ranking of potentially suitable sites, and 7) identification of sites for suitability investigations. The first 3 steps give the remaining areas that meet the minimum requirements. The criteria of the first 3 steps are: extensive vertical movements, active disturbance zones, seismic activity and volcanic activity, as for the 4 last steps criteria are based on geo- and socio- scientific weighing, voluntariness and regional mediation. (A.C.)

  19. Development of site selection criteria for radioactive waste disposal in view of favourable geological settings in Germany

    Energy Technology Data Exchange (ETDEWEB)

    Baltes, B.; Brewitz, W. [Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS) mbH, Cologne (Germany)

    2001-07-01

    In Germany it is intended to dispose of all types of radioactive waste in deep geological formations. Since the government has doubts regarding the suitability of the Gorleben site, further sites in different host rock formations have to be investigated. This investigation process has to be carried out with respect to technical suitability and safety as well as to public acceptance. A Committee has been established whose mandate is to develop a comprehensible procedure for the selection of sites for radioactive waste disposal in Germany. The Committee developed an iterative procedure which provides, besides the increase of transparency, the necessary flexibility in dealing with assessment results. The method is governed by geo-scientific and social-scientific criteria that are presented in this paper. 7 steps have been identified in the procedure: 1) exclusion of areas with obviously unfavourable conditions, 2) identification of areas with favourable geological settings, 3) exclusion of areas for socio-scientific reasons, 4) identification of regions with favourable conditions and ranking of regions, 5) identification of sites for further identification, 6) above-ground site investigation and ranking of potentially suitable sites, and 7) identification of sites for suitability investigations. The first 3 steps give the remaining areas that meet the minimum requirements. The criteria of the first 3 steps are: extensive vertical movements, active disturbance zones, seismic activity and volcanic activity, as for the 4 last steps criteria are based on geo- and socio- scientific weighing, voluntariness and regional mediation. (A.C.)

  20. Draft environmental assessment: Yucca Mountain site, Nevada research and development area, Nevada. Nuclear Waste Policy Act (Section 112)

    International Nuclear Information System (INIS)

    1984-12-01

    In February 1983, the US Department of Energy (DOE) identified the Yucca Mountain site in Nevada as one of nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Yucca Mountain site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for Nuclear Waste Repositories. These evaluations are reported in this draft environmental assessment (EA), which is being issued for public review and comment. The DOE findings and determinations that are based on these evaluations are preliminary and subject to public review and comment. A final EA will be prepared after considering the comments received on the draft EA. The Yucca Mountain site is located in the Great Basin, one of five distinct geohydrologic settings that are being considered for the first repository. On the basis of the evaluations reported in this draft EA, the DOE has found that the Yucca Mountain site is not disqualified under the guidelines. The DOE has also found that it is suitable for site characterization because the evidence does not support a conclusion that the site will not be able to meet each of the qualifying conditions specified in the guidelines. On the basis of these findings, the DOE is proposing to nominate the Yucca Mountain site as one of five sites suitable for characterization. Furthermore, having performed a comparative evaluation of the five sites proposed for nomination, the DOE has determined that the Yucca Mountain site is one of three sites preferred for site characterization

  1. Radiograph identifying means

    International Nuclear Information System (INIS)

    Sheldon, A.D.

    1983-01-01

    A flexible character-indentable plastics embossing tape is backed by and bonded to a lead strip, not more than 0.025 inches thick, to form a tape suitable for identifying radiographs. The lead strip is itself backed by a relatively thin and flimsy plastics or fabric strip which, when removed, allows the lead plastic tape to be pressure-bonded to the surface to be radiographed. A conventional tape-embossing gun is used to indent the desired characters in succession into the lead-backed tape, without necessarily severing the lead; and then the backing strip is peeled away to expose the layer of adhesive which pressure-bonds the indented tape to the object to be radiographed. X-rays incident on the embossed tape will cause the raised characters to show up dark on the subsequently-developed film, whilst the raised side areas will show up white. Each character will thus stand out on the developed film. (author)

  2. Site description of Laxemar at completion of the site investigation phase. SDM-Site Laxemar

    International Nuclear Information System (INIS)

    2009-12-01

    The Swedish Nuclear Fuel and Waste Management Company (SKB) has undertaken site characterisation in two different areas, Forsmark and Laxemar-Simpevarp, in order to identify a suitable location for a geological repository of spent nuclear fuel according to the KBS-3 method. The site investigations have been conducted in campaigns, punctuated by data freezes. After each data freeze, the site data have been analysed and modelling has been carried out with the overall purpose to develop a site descriptive model (SDM). The site descriptive model is used by repository engineering to design the underground facility and to develop a repository layout adapted to the site. It is also essential for safety assessment, since the SDM is the only source for site-specific input. Another important use of the site descriptive model is in the environmental impact assessment. An SDM is an integrated model of geology, thermal properties, rock mechanics, hydrogeology, hydrogeochemistry, bedrock transport properties and a description of the surface system. The site descriptive model compiled in the current report, SDM-Site Laxemar, presents an integrated understanding of the Laxemar-Simpevarp area (with special emphasis on the Laxemar subarea) at the completion of the surface-based investigations, which were conducted during the period 2002 to 2007. A summary is also provided of the abundant underlying data and the discipline specific models that support the site understanding. The description relies heavily on background reports that address, in particular, details of the data analyses and modelling of the different disciplines. The Laxemar-Simpevarp area is located in the province of Smaaland within the municipality of Oskarshamn, about 230 km south of Stockholm. The candidate area for site investigation is located along the shoreline of the strait of Kalmarsund, within a 1.8 billion year old suite of well preserved bedrock belonging to the Transscandinavian Igneous Belt formed during

  3. Site description of Forsmark at completion of the site investigation phase. SDM-Site Forsmark

    Energy Technology Data Exchange (ETDEWEB)

    2008-12-15

    The Swedish Nuclear Fuel and Waste Management Co., SKB, has undertaken site characterisation in two different areas, Forsmark and Laxemar-Simpevarp, in order to identify a suitable location for a geological repository of spent nuclear fuel according to the KBS-3 method. The site investigations have been conducted in campaigns, punctuated by data freezes. After each data freeze, the site data have been analysed and modelling has been carried out with the overall purpose to develop a site descriptive model (SDM). The site descriptive model is used by repository engineering to design the underground facility and to develop a repository layout adapted to the site. It is also essential for safety assessment, since the model is the only source for site-specific input. Another important use of the site descriptive model is in the environmental impact assessment. An SDM is an integrated model for geology, thermal properties, rock mechanics, hydrogeology, hydrogeochemistry, bedrock transport properties and a description of the surface system. The site descriptive model compiled in the current report, SDM-Site, presents an integrated understanding of the Forsmark area at the completion of the surface-based investigations, which were conducted at Forsmark during the period 2002 to 2007. It also provides a summary of the abundant underlying data and the discipline-specific models that support the site understanding. The description relies heavily on background reports that address, in particular, details in data analyses and modelling in the different disciplines. The Forsmark area is located in northern Uppland within the municipality of Oesthammar, about 120 km north of Stockholm. The candidate area for site investigation is located along the shoreline of Oeregrundsgrepen, within the north-western part of a major tectonic lens that formed between 1.87 and 1.85 billion years ago during the Svecokarelian orogeny. The candidate area is approximately 6 km long and 2 km wide. The

  4. Site description of Laxemar at completion of the site investigation phase. SDM-Site Laxemar

    Energy Technology Data Exchange (ETDEWEB)

    2009-12-15

    The Swedish Nuclear Fuel and Waste Management Company (SKB) has undertaken site characterisation in two different areas, Forsmark and Laxemar-Simpevarp, in order to identify a suitable location for a geological repository of spent nuclear fuel according to the KBS-3 method. The site investigations have been conducted in campaigns, punctuated by data freezes. After each data freeze, the site data have been analysed and modelling has been carried out with the overall purpose to develop a site descriptive model (SDM). The site descriptive model is used by repository engineering to design the underground facility and to develop a repository layout adapted to the site. It is also essential for safety assessment, since the SDM is the only source for site-specific input. Another important use of the site descriptive model is in the environmental impact assessment. An SDM is an integrated model of geology, thermal properties, rock mechanics, hydrogeology, hydrogeochemistry, bedrock transport properties and a description of the surface system. The site descriptive model compiled in the current report, SDM-Site Laxemar, presents an integrated understanding of the Laxemar-Simpevarp area (with special emphasis on the Laxemar subarea) at the completion of the surface-based investigations, which were conducted during the period 2002 to 2007. A summary is also provided of the abundant underlying data and the discipline specific models that support the site understanding. The description relies heavily on background reports that address, in particular, details of the data analyses and modelling of the different disciplines. The Laxemar-Simpevarp area is located in the province of Smaaland within the municipality of Oskarshamn, about 230 km south of Stockholm. The candidate area for site investigation is located along the shoreline of the strait of Kalmarsund, within a 1.8 billion year old suite of well preserved bedrock belonging to the Transscandinavian Igneous Belt formed during

  5. Site description of Forsmark at completion of the site investigation phase. SDM-Site Forsmark

    International Nuclear Information System (INIS)

    2008-12-01

    The Swedish Nuclear Fuel and Waste Management Co., SKB, has undertaken site characterisation in two different areas, Forsmark and Laxemar-Simpevarp, in order to identify a suitable location for a geological repository of spent nuclear fuel according to the KBS-3 method. The site investigations have been conducted in campaigns, punctuated by data freezes. After each data freeze, the site data have been analysed and modelling has been carried out with the overall purpose to develop a site descriptive model (SDM). The site descriptive model is used by repository engineering to design the underground facility and to develop a repository layout adapted to the site. It is also essential for safety assessment, since the model is the only source for site-specific input. Another important use of the site descriptive model is in the environmental impact assessment. An SDM is an integrated model for geology, thermal properties, rock mechanics, hydrogeology, hydrogeochemistry, bedrock transport properties and a description of the surface system. The site descriptive model compiled in the current report, SDM-Site, presents an integrated understanding of the Forsmark area at the completion of the surface-based investigations, which were conducted at Forsmark during the period 2002 to 2007. It also provides a summary of the abundant underlying data and the discipline-specific models that support the site understanding. The description relies heavily on background reports that address, in particular, details in data analyses and modelling in the different disciplines. The Forsmark area is located in northern Uppland within the municipality of Oesthammar, about 120 km north of Stockholm. The candidate area for site investigation is located along the shoreline of Oeregrundsgrepen, within the north-western part of a major tectonic lens that formed between 1.87 and 1.85 billion years ago during the Svecokarelian orogeny. The candidate area is approximately 6 km long and 2 km wide. The

  6. Agronomic Suitability of Bioenergy Crops in Mississippi

    Energy Technology Data Exchange (ETDEWEB)

    Lemus, Rocky; Baldwin, Brian; Lang, David

    2011-10-01

    In Mississippi, some questions need to be answered about bioenergy crops: how much suitable land is available? How much material can that land produce? Which production systems work best in which scenarios? What levels of inputs will be required for productivity and longterm sustainability? How will the crops reach the market? What kinds of infrastructure will be necessary to make that happen? This publication helps answer these questions: • Which areas in the state are best for bioenergy crop production? • How much could these areas produce sustainably? • How can bioenergy crops impact carbon sequestration and carbon credits? âÂÃÃÂ

  7. Hanford Site Infrastructure Plan

    International Nuclear Information System (INIS)

    1990-01-01

    The Hanford Site Infrastructure Plan (HIP) has been prepared as an overview of the facilities, utilities, systems, and services that support all activities on the Hanford Site. Its purpose is three-fold: to examine in detail the existing condition of the Hanford Site's aging utility systems, transportation systems, Site services and general-purpose facilities; to evaluate the ability of these systems to meet present and forecasted Site missions; to identify maintenance and upgrade projects necessary to ensure continued safe and cost-effective support to Hanford Site programs well into the twenty-first century. The HIP is intended to be a dynamic document that will be updated accordingly as Site activities, conditions, and requirements change. 35 figs., 25 tabs

  8. Equilibrium Strategy Based Recycling Facility Site Selection towards Mitigating Coal Gangue Contamination

    Directory of Open Access Journals (Sweden)

    Jiuping Xu

    2017-02-01

    Full Text Available Environmental pollution caused by coal gangue has been a significant challenge for sustainable development; thus, many coal gangue reduction approaches have been proposed in recent years. In particular, coal gangue facility (CGF construction has been considered as an efficient method for the control and recycling of coal gangue. Meanwhile, the identification and selection of suitable CGF sites is a fundamental task for the government. Therefore, based on the equilibrium strategy, a site selection approach under a fuzzy environment is developed to mitigate coal gangue contamination, which integrates a geographical information system (GIS technique and a bi-level model to identify candidate CGF sites and to select the most suitable one. In this situation, the GIS technique used to identify potential feasible sites is able to integrate a great deal of geographical data tofitwithpracticalcircumstances;thebi-levelmodelusedtoscreentheappropriatesitecanreasonably dealwiththeconflictsbetweenthelocalauthorityandthecolliery. Moreover,aKarush–Kuhn–Tucker (KKT condition-based approach is used to find an optimal solution, and a case study is given to demonstrate the effectiveness of the proposed method. The results across different scenarios show that appropriate site selection can achieve coal gangue reduction targets and that a suitable excess stack level can realize an environmental-economic equilibrium. Finally, some propositions and management recommendations are given.

  9. An Integrated Approach to Mitigation Wetland Site Selection: A Case Study in Gwacheon, Korea

    Directory of Open Access Journals (Sweden)

    Junga Lee

    2015-03-01

    Full Text Available This paper presents an integrated approach to mitigation wetland site selection using functional landscape connectivity and landscape structure. This approach enables landscape designers to evaluate the relative priorities of mitigation wetland areas based on functional landscape connectivity and wildlife mobility, as well as landscape structure, composition, and configuration. The least-cost path method is used to evaluate candidate sites for mitigation wetlands with regard to wildlife movement. A set of assessments for landscape indices using FRAGSTATS was applied to identify suitable mitigation wetland areas on the basis of landscape connectivity, composition, and configuration. The study was conducted in Gwacheon, Korea, where there are plans for regional development that will change the landscape. In the first step, a group of 14 candidate sites is identified via analysis of functional landscape connectivity using the least-cost path method. In the second step, candidate mitigation wetland areas are ranked according to landscape connectivity and composition. The five mitigation wetland areas that were found to be suitable were analyzed based on landscape configuration at the class level. This study demonstrates that functional landscape connectivity and landscape structure are important aspects to consider when identifying suitable sites for mitigation wetland planning and restoration.

  10. Habitat suitability and movement corridors of grey wolf (Canis lupus) in Northern Pakistan

    Science.gov (United States)

    Kabir, Muhammad; Hameed, Shoaib; Ali, Hussain; Bosso, Luciano; Din, Jaffar Ud; Bischof, Richard; Redpath, Steve

    2017-01-01

    Habitat suitability models are useful to understand species distribution and to guide management and conservation strategies. The grey wolf (Canis lupus) has been extirpated from most of its historic range in Pakistan primarily due to its impact on livestock and livelihoods. We used non-invasive survey data from camera traps and genetic sampling to develop a habitat suitability model for C. lupus in northern Pakistan and to explore the extent of connectivity among populations. We detected suitable habitat of grey wolf using a maximum entropy approach (Maxent ver. 3.4.0) and identified suitable movement corridors using the Circuitscape 4.0 tool. Our model showed high levels of predictive performances, as seen from the values of area under curve (0.971±0.002) and true skill statistics (0.886±0.021). The main predictors for habitat suitability for C. lupus were distances to road, mean temperature of the wettest quarter and distance to river. The model predicted ca. 23,129 km2 of suitable areas for wolf in Pakistan, with much of suitable habitat in remote and inaccessible areas that appeared to be well connected through vulnerable movement corridors. These movement corridors suggest that potentially the wolf range can expand in Pakistan’s Northern Areas. However, managing protected areas with stringent restrictions is challenging in northern Pakistan, in part due to heavy dependence of people on natural resources. The habitat suitability map provided by this study can inform future management strategies by helping authorities to identify key conservation areas. PMID:29121089

  11. Draft environmental assessment: reference repository location, Hanford Site, Washington. Nuclear Waste Policy Act (Section 112)

    International Nuclear Information System (INIS)

    1984-12-01

    In February 1983, the US Department of Energy (DOE) identified a reference repository location at the Hanford Site in Washington as one of nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the reference repository location at the Hanford Site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for Nuclear Waste Repositories. These evaluations are reported in this draft environmental assessment (EA), which is being issued for public review and comment. The DOE findings and determinations that are based on these evaluations are preliminary and subject to public review and comment. A final EA will be prepared after considering the comments received on the draft EA. The reference repository location at Hanford is located in the Columbia Plateau, one of five distinct geohydrologic settings that are being considered for the first repository. On the basis of the evaluations reported in this draft EA, the DOE has found that the reference repository location at Hanford is not disqualified under the guidelines. The DOE has also found that it is suitable for site characterization because the evidence does not support a conclusion that the site will not be able to meet each of the qualifying conditions specified in the guidelines. On the basis of these findings, the DOE is proposing to nominate the reference repository location at Hanford as one of five sites suitable for characterization. Furthermore, having performed a comparative evaluation of the five sites proposed for nomination, the DOE has determined that the reference repository location at Hanford is one of three sites preferred for site characterization

  12. Suitability of Sites for Hazardous Waste Disposal, Concord Naval Weapons Station, Concord, California.

    Science.gov (United States)

    1987-09-01

    mica flakes. The mica-bearing sandy soil Is most likely a product of riverine processes in the valley of the Sacramento - San Joaquin system and from a...Quad- rangle, Contra Costa County, California, US Geological Survey, Open-File Report 80-547. 0 _ 1980b. Preliminary geologic map of the Honker Bay...Quadrangle, Solano and Contra Costa Counties, California, US Geological Survey, Open-File Report 80-2009. * 1980c. Preliminary geologic map of the