WorldWideScience

Sample records for identify capability enhancements

  1. Identifying 21st Century Capabilities

    Science.gov (United States)

    Stevens, Robert

    2012-01-01

    What are the capabilities necessary to meet 21st century challenges? Much of the literature on 21st century skills focuses on skills necessary to meet those challenges associated with future work in a globalised world. The result is a limited characterisation of those capabilities necessary to address 21st century social, health and particularly…

  2. Enhancing radiation biodosimetry capability

    International Nuclear Information System (INIS)

    Alok, A.; Kumar, A.; Kulshrestra, S.; Choudhary, S.; Bhagi, S.; Adhikari, J.S.; Chaudhury, N.K.

    2016-01-01

    Biodosimetry laboratories are necessary for quick and accurate assessment of absorbed radiation dose in suspected individuals for their medical management. The method is based on dicentric chromosomal assay (Gold standard). This assay is completely manual and time consuming, require skill and competency of laboratory staff. There is a necessity of more biodosimetry labs within country and networking within and at international level for enhancing medical preparedness for management of radiation emergency

  3. Fused Reality for Enhanced Flight Test Capabilities

    Science.gov (United States)

    Bachelder, Ed; Klyde, David

    2011-01-01

    The feasibility of using Fused Reality-based simulation technology to enhance flight test capabilities has been investigated. In terms of relevancy to piloted evaluation, there remains no substitute for actual flight tests, even when considering the fidelity and effectiveness of modern ground-based simulators. In addition to real-world cueing (vestibular, visual, aural, environmental, etc.), flight tests provide subtle but key intangibles that cannot be duplicated in a ground-based simulator. There is, however, a cost to be paid for the benefits of flight in terms of budget, mission complexity, and safety, including the need for ground and control-room personnel, additional aircraft, etc. A Fused Reality(tm) (FR) Flight system was developed that allows a virtual environment to be integrated with the test aircraft so that tasks such as aerial refueling, formation flying, or approach and landing can be accomplished without additional aircraft resources or the risk of operating in close proximity to the ground or other aircraft. Furthermore, the dynamic motions of the simulated objects can be directly correlated with the responses of the test aircraft. The FR Flight system will allow real-time observation of, and manual interaction with, the cockpit environment that serves as a frame for the virtual out-the-window scene.

  4. Enhancement of EAST plasma control capabilities

    Energy Technology Data Exchange (ETDEWEB)

    Xiao, Bingjia, E-mail: bjxiao@ipp.ac.cn [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei (China); School of Nuclear Science and Technology, University of Science and Technology of China, Hefei (China); Yuan, Qiping; Luo, Zhengping; Huang, Yao; Liu, Lei; Guo, Yong; Pei, Xiaofang; Chen, Shuliang [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei (China); Humphreys, D.A.; Hyatt, A.W. [General Atomics, P.O. Box 85608, San Diego, CA 92186-5608 (United States); Mueller, Dennis [Princeton Plasma Physics Laboratory, Princeton, NJ (United States); Calabró, G.; Crisanti, F. [ENEA UnitàTecnicaFusione, C.R. Frascati, Via E. Fermi 45, 00044 Frascati, Roma (Italy); Albanese, R.; Ambrosino, R. [CREATE, Università di Napoli Federicao II, Università di Cassino and Università di Napoli Parthenope, Via Claudio 19, 80125 Napoli (Italy)

    2016-11-15

    Highlights: • Parallel plasma equilibrium reconstruction using GPU for real-time control on EAST. • Vertical control using Bang-bang + PID method to improve the response and minimize the oscillation caused by the latency. • Quasi-snow flake divertor plasma configuration has been demonstrated on EAST. - Abstract: In order to improve the plasma control performance and enhance the capability for advanced plasma control, new algorithms such as PEFIT/ISOFLUX plasma shape feedback control, quasi-snowflake plasma shape development and vertical control under new vertical control power supply, have been implemented and experimentally tested and verified in EAST 2014 campaign. P-EFIT is a rewritten version of EFIT aiming at fast real-time equilibrium reconstruction by using GPU for parallelized computation. Successful control using PEFIT/ISOFLUX was established in dedicated experiment. Snowfldivertor plasma shape has the advantage of spreading heat over the divertor target and a quasi-snowflake (QSF) configuration was achieved in discharges with I{sub p} = 0.25 MA and B{sub t} = 1.8T, κ∼1.9, by plasma position feedback control. The shape feedback control to achieve QSF shape has been preliminary implemented by using PEFIT and the initial experimental test has been done. For more robust vertical instability control, the inner coil (IC) and its power supply have been upgraded. A new control algorithm with the combination of Bang-bang and PID controllers has been developed. It is shown that new vertical control power supply together with the new control algorithms results in higher vertical controllability.

  5. COMPETITIVE INTELLIGENCE: THE ENHANCING ROLE OF ORGANIZATIONAL LEARNING CAPABILITY

    OpenAIRE

    HAMAD, Zaina Mustafa Mahmoud; YOZGAT, Ugur

    2017-01-01

    Performinga strong intelligence grants an organization a guaranteeof long-term success. This paper investigates the enhancing effect of organizational learning capabilities on competitive intelligence atthe commercial banks in Jordan. A sample within top and middle managements was used.Measurement instrument validity and model fit were assessed before testinghypotheses. This study emphasizes the role learning capability plays inenhancing intelligence. Key findings support importance of organi...

  6. Enhanced Capabilities for Subcritical Experiments (ECSE) Risk Management Plan

    Energy Technology Data Exchange (ETDEWEB)

    Urban, Mary Elizabeth [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Process Modeling and Analysis Group

    2016-05-02

    Risk is a factor, element, constraint, or course of action that introduces an uncertainty of outcome that could impact project objectives. Risk is an inherent part of all activities, whether the activity is simple and small, or large and complex. Risk management is a process that identifies, evaluates, handles, and monitors risks that have the potential to affect project success. The risk management process spans the entire project, from its initiation to its successful completion and closeout, including both technical and programmatic (non-technical) risks. This Risk Management Plan (RMP) defines the process to be used for identifying, evaluating, handling, and monitoring risks as part of the overall management of the Enhanced Capabilities for Subcritical Experiments (ECSE) ‘Project’. Given the changing nature of the project environment, risk management is essentially an ongoing and iterative process, which applies the best efforts of a knowledgeable project staff to a suite of focused and prioritized concerns. The risk management process itself must be continually applied throughout the project life cycle. This document was prepared in accordance with DOE O 413.3B, Program and Project Management for the Acquisition of Capital Assets, its associated guide for risk management DOE G 413.3-7, Risk Management Guide, and LANL ADPM AP-350-204, Risk and Opportunity Management.

  7. Enhancement of kalman filter single loss detection capability

    International Nuclear Information System (INIS)

    Morrison, G.W.; Downing, D.J.; Pike, D.H.

    1980-01-01

    A new technique to significantly increase the sensitivity of the Kalman filter to detect one-time losses for nuclear marterial accountability and control has been developed. The technique uses the innovations sequence obtained from a Kalman filter analysis of a material balance area. The innovations are distributed as zero mean independent Gaussion random variables with known variance. This property enables an estimator to be formed with enhanced one time loss detection capabilities. Simulation studies of a material balance area indicate the new estimator greatly enhances the one time loss detection capability of the Kalman filter

  8. Core Capabilities and Technical Enhancement -- FY-98 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Miller, David Lynn

    1999-04-01

    The Core Capability and Technical Enhancement (CC&TE) Program, a part of the Verification, Validation, and Engineering Assessment Program, was implemented to enhance and augment the technical capabilities of the Idaho National Engineering and Environmental Laboratory (INEEL). The purpose for strengthening the technical capabilities of the INEEL is to provide the technical base to serve effectively as the Environmental Management Laboratory for the Office of Environmental Management (EM). An analysis of EM's science and technology needs as well as the technology investments currently being made by EM across the complex was used to formulate a portfolio of research activities designed to address EM's needs without overlapping work being done elsewhere. An additional purpose is to enhance and maintain the technical capabilities and research infrastructure at the INEEL. This is a progress report for fiscal year 1998 for the five CC&TE research investment areas: (a) transport aspects of selective mass transport agents, (b) chemistry of environmental surfaces, (c) materials dynamics, (d) characterization science, and (e) computational simulation of mechanical and chemical systems. In addition to the five purely technical research areas, this report deals with the science and technology foundations element of the CC&TE from the standpoint of program management and complex-wide issues. This report also provides details of ongoing and future work in all six areas.

  9. Core capabilities and technical enhancement, FY-98 annual report

    Energy Technology Data Exchange (ETDEWEB)

    Miller, D.L.

    1999-04-01

    The Core Capability and Technical Enhancement (CCTE) Program, a part of the Verification, Validation, and Engineering Assessment Program, was implemented to enhance and augment the technical capabilities of the Idaho National Engineering and Environmental Laboratory (INEEL). The purpose for strengthening the technical capabilities of the INEEL is to provide the technical base to serve effectively as the Environmental Management Laboratory for the Department of Energy's Office of Environmental Management (EM). An analysis of EM's science and technology needs as well as the technology investments currently being made by EM across the complex was used to formulate a portfolio of research activities designed to address EM's needs without overlapping work being done elsewhere. An additional purpose is to enhance and maintain the technical capabilities and research infrastructure at the INEEL. This is a progress report for fiscal year 1998 for the five CCTE research investment areas: (a) transport aspects of selective mass transport agents, (b) chemistry of environmental surfaces, (c) materials dynamics, (d) characterization science, and (e) computational simulation of mechanical and chemical systems. In addition to the five purely technical research areas, this report deals with the science and technology foundations element of the CCTE from the standpoint of program management and complex-wide issues. This report also provides details of ongoing and future work in all six areas.

  10. The enhancements and testing for the MCNPX depletion capability

    International Nuclear Information System (INIS)

    Fensin, M. L.; Hendricks, J. S.; Anghaie, S.

    2008-01-01

    Monte Carlo-linked depletion methods have gained recent interest due to the ability to more accurately model true system physics and better track the evolution of temporal nuclide inventory by simulating the actual physical process. The integration of INDER90 into the MCNPX Monte Carlo radiation transport code provides a completely self-contained Monte- Carlo-linked depletion capability in a single Monte Carlo code that is compatible with most nuclear criticality (KCODE) particle tracking features in MCNPX. MCNPX depletion tracks all necessary reaction rates and follows as many isotopes as cross section data permits in order to achieve a highly accurate temporal nuclide inventory solution. We describe here the depletion methodology dating from the original linking of MONTEBURNS and MCNP to the first public release of the integrated capability (MCNPX 2. 6.B, June, 2006) that has been reported previously. Then we further detail the many new depletion capability enhancements since then leading to the present capability. The H.B. Robinson benchmark calculation results are also reported. The new MCNPX depletion capability enhancements include: (1) allowing the modeling of as large a system as computer memory capacity permits; (2) tracking every fission product available in ENDF/B VII. 0; (3) enabling depletion in repeated structures geometries such as repeated arrays of fuel pins; (4) including metastable isotopes in burnup; and (5) manually changing the concentrations of key isotopes during different time steps to simulate changing reactor control conditions such as dilution of poisons to maintain criticality during burnup. These enhancements allow better detail to model the true system physics and also improve the robustness of the capability. The H.B. Robinson benchmark calculation was completed in order to determine the accuracy of the depletion solution. Temporal nuclide computations of key actinide and fission products are compared to the results of other

  11. Enhanced Monte-Carlo-Linked Depletion Capabilities in MCNPX

    International Nuclear Information System (INIS)

    Fensin, Michael L.; Hendricks, John S.; Anghaie, Samim

    2006-01-01

    . These capabilities have been enhanced by the two major new improvements described here. Further improvements are under development to enhance the usefulness of this new capability. (authors)

  12. Enhancing the Radio Astronomy Capabilities at NASA's Deep Space Network

    Science.gov (United States)

    Lazio, Joseph; Teitelbaum, Lawrence; Franco, Manuel M.; Garcia-Miro, Cristina; Horiuchi, Shinji; Jacobs, Christopher; Kuiper, Thomas; Majid, Walid

    2015-08-01

    NASA's Deep Space Network (DSN) is well known for its role in commanding and communicating with spacecraft across the solar system that produce a steady stream of new discoveries in Astrophysics, Heliophysics, and Planetary Science. Equipped with a number of large antennas distributed across the world, the DSN also has a history of contributing to a number of leading radio astronomical projects. This paper summarizes a number of enhancements that are being implemented currently and that are aimed at increasing its capabilities to engage in a wide range of science observations. These enhancements include* A dual-beam system operating between 18 and 27 GHz (~ 1 cm) capable of conducting a variety of molecular line observations, searches for pulsars in the Galactic center, and continuum flux density (photometry) of objects such as nearby protoplanetary disks* Enhanced spectroscopy and pulsar processing backends for use at 1.4--1.9 GHz (20 cm), 18--27 GHz (1 cm), and 38--50 GHz (0.7 cm)* The DSN Transient Observatory (DTN), an automated, non-invasive backend for transient searching* Larger bandwidths (>= 0.5 GHz) for pulsar searching and timing; and* Improved data rates (2048 Mbps) and better instrumental response for very long baseline interferometric (VLBI) observations with the new DSN VLBI processor (DVP), which is providing unprecedented sensitivity for maintenance of the International Celestial Reference Frame (ICRF) and development of future versions.One of the results of these improvements is that the 70~m Deep Space Station 43 (DSS-43, Tidbinbilla antenna) is now the most sensitive radio antenna in the southern hemisphere. Proposals to use these systems are accepted from the international community.Part of this research was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics & Space Administration.

  13. Lean process management implementation through enhanced problem solving capabilities

    Directory of Open Access Journals (Sweden)

    Perumal Puvanasvaran

    2010-12-01

    Full Text Available All Original Equipment Manufacturers (OEM organizations in Aerospace, Automotive and Electronics industries had to upgrade their functions. These organizations including suppliers and solutions providers are duty bound to improve their functions through strategic initiatives. One such initiative is Lean Process Management. Lean Process Management has proven to aid organizations in developing manufacturing and administrative management solutions and make the organization a leaner at the same time a ‘fitter’ one, achieving World Class standards in terms of production, quality, marketing, etc, etc. The issue or problem is, although a number of authors, experts, researchers have discussed the lean process management as part organization centric issues, they failed to provide an effective lean process management system. Besides the need to formulate an effective lean process as suggested by some authors, another important reason suggested is the employee’s development aspect regarding how to unlock the infinite potential of their workforce. This employee’s development is basically the problem solving capabilities of the employees while implementing the Lean through clear cutting protocols or processes of Lean Process Management. The employees need to be developed and equipped to contribute optimally to the process. Because of this scenario, the main objective of this study is to develop an employees development system which the author has acronym or trademark it as People Development System (PDS to enhance problem solving capability among its employees while implementing the lean process management there. Although, the PDS can be implemented throughout the organization, if it is implemented in a particular department in an organization, it will be feasible to study and analyze its effectiveness in-depth. So, this study documents and analyzes the implementation of Lean process in the Kitting Department of the aerospace company, ABC Company

  14. Enhancement Of Sensing Capabilities And Functionalization Of Optical Microresonators

    Science.gov (United States)

    Cocking, Alexander

    Optical microresonators have been demonstrated to provide a large enhancement in electric field by containing an resonant mode in a very small volume. This resonant enhancement is proportional to the quality of the resonator, which for microspheres has been demonstrated to be on the order of 1010. These devices can be leveraged to greatly improve light-matter interaction and for this reason the theoretical background of optical microresonators is discussed in the second chapter. This includes the use of COMSOL Multiphysics to model the mode structure and scattering from different resonator geometries. The second chapter also contains details on the fabrication and experimental design of optical microresonators. This includes the fabrication of fiber tapers for evanescent wave coupling into the devices. Once the theoretical framework for utilizing resonators as tools for enhancement has been established in the second chapter, we progress to the discussion of the microbubble geometry and its potential for use as an on-chip sensor system. Topics covered include design, fabrication, and theoretical analysis of the mode structure in this geometry. Modal interaction with a liquid filled microbubble is demonstrated. Additionally, the use of microbubble resonators as highly accurate temperature sensors is demonstrated experimentally and theoretically. In chapter 4 we investigate the use of silica microspheres as sensing devices; specifically, using them for the purpose of sensing nano-particles and chemicals in incredibly minute quantities. In this section microresonators are demonstrated to provide enhancement to Raman scattering from nano-scale particles. This configuration retains the traditional sensing methods of resonators by observing mode shifting and splitting in the resonance spectrum, while adding in a label-free sensing ability to determine material composition on adhered micro and nanoparticles. The fifth chapter discusses the characterization of a new class

  15. Knowledge Management for Enhancing Regulatory Body Capabilities in Thailand

    International Nuclear Information System (INIS)

    Apichaibukol, A.; Pakdee, K.

    2016-01-01

    Full text: In order to be a learning organization, the Office of Atoms for Peace (OAP) has appointed a knowledge-management team in an attempt to manage internal knowledge, both tacit knowledge and explicit knowledge, systematically. In principle, the seven steps of knowledge management will be applied for OAP KM, namely; 1. Knowledge identification including the knowledge required of the Regulatory Body. 2. Knowledge creation and acquisition including knowledge sharing, transfer and how to maintain knowledge external factors such as a customers, stakeholder, etc. 3. Knowledge organization based on knowledge structure is needed for a systematic knowledge retention in the future. 4. Knowledge refinement with ISO standards in document storage. 5. Knowledge access for example, using information technology management through web board. 6. Knowledge sharing, OAP staff through numerous methods designed to transfer implicit and tacit knowledge such as formal classroom and on-the-job training, informal Communities of Practice, mentoring. 7. Learning is OAP group continually enhancing their capabilities and making decisions, solving problems and improving the organization. OAP staff could apply knowledge for organization development and planning for a supporting guideline. (author

  16. Enhanced science capability on the International Space Station

    Science.gov (United States)

    Felice, Ronald R.; Kienlen, Mike

    2002-12-01

    It is inevitable that the International Space Station (ISS) will play a significant role in the conduct of science in space. However, in order to provide this service to a wide and broad community and to perform it cost effectively, alternative concepts must be considered to complement NASA"s Institutional capability. Currently science payload forward and return data services must compete for higher priority ISS infrastructure support requirements. Furthermore, initial astronaut crews will be limited to a single shift. Much of their time and activities will be required to meet their physical needs (exercise, recreation, etc.), station maintenance, and station operations, leaving precious little time to actively conduct science payload operations. ISS construction plans include the provisioning of several truss mounted, space-hardened pallets, both zenith and nadir facing. The ISS pallets will provide a platform to conduct both earth and space sciences. Additionally, the same pallets can be used for life and material sciences, as astronauts could place and retrieve sealed canisters for long-term micro-gravity exposure. Thus the pallets provide great potential for enhancing ISS science return. This significant addition to ISS payload capacity has the potential to exacerbate priorities and service contention factors within the exiting institution. In order to have it all, i.e., more science and less contention, the pallets must be data smart and operate autonomously so that NASA institutional services are not additionally taxed. Specifically, the "Enhanced Science Capability on the International Space Station" concept involves placing data handling and spread spectrum X-band communications capabilities directly on ISS pallets. Spread spectrum techniques are considered as a means of discriminating between different pallets as well as to eliminate RFI. The data and RF systems, similar to that of "free flyers", include a fully functional command and data handling system

  17. The Orphee reactor current status and proposed enhancement of experimental capabilities

    International Nuclear Information System (INIS)

    Breant, P.

    1990-01-01

    This report provides a description of the Orphee reactor, together with a rapid assessment of its experimental and research capabilities. The plans for enhancing the reactor's experimental capabilities are also presented. (author)

  18. SIGMA Release v1.2 - Capabilities, Enhancements and Fixes

    Energy Technology Data Exchange (ETDEWEB)

    Mahadevan, Vijay [Argonne National Lab. (ANL), Argonne, IL (United States); Grindeanu, Iulian R. [Argonne National Lab. (ANL), Argonne, IL (United States); Ray, Navamita [Argonne National Lab. (ANL), Argonne, IL (United States); Jain, Rajeev [Argonne National Lab. (ANL), Argonne, IL (United States); Wu, Danqing [Argonne National Lab. (ANL), Argonne, IL (United States)

    2015-09-30

    In this report, we present details on SIGMA toolkit along with its component structure, capabilities, and feature additions in FY15, release cycles, and continuous integration process. These software processes along with updated documentation are imperative to successfully integrate and utilize in several applications including the SHARP coupled analysis toolkit for reactor core systems funded under the NEAMS DOE-NE program.

  19. SIGMA Release v1.2 - Capabilities, Enhancements and Fixes

    International Nuclear Information System (INIS)

    Mahadevan, Vijay; Grindeanu, Iulian R.; Ray, Navamita; Jain, Rajeev; Wu, Danqing

    2015-01-01

    In this report, we present details on SIGMA toolkit along with its component structure, capabilities, and feature additions in FY15, release cycles, and continuous integration process. These software processes along with updated documentation are imperative to successfully integrate and utilize in several applications including the SHARP coupled analysis toolkit for reactor core systems funded under the NEAMS DOE-NE program.

  20. Managing climatic risks for enhanced food security: Key information capabilities

    NARCIS (Netherlands)

    Balaghi, R.; Badjeck, M.C.; Bakari, D.; Pauw, de E.D.; Wit, de A.J.W.; Defourny, P.; Donato, S.; Gommes, R.; Jlibene, M.; Ravelo, A.C.; Sivakumar, M.V.K.; Telahigue, N.; Tychon, B.

    2010-01-01

    Food security is expected to face increasing challenges from climatic risks that are more and more exacerbated by climate change, especially in the developing world. This document lists some of the main capabilities that have been recently developed, especially in the area of operational

  1. Advanced Reactive Power Reserve Management Scheme to Enhance LVRT Capability

    Directory of Open Access Journals (Sweden)

    Hwanik Lee

    2017-10-01

    Full Text Available Abstract: To increase the utilization of wind power in the power system, grid integration standards have been proposed for the stable integration of large-scale wind power plants. In particular, fault-ride-through capability, especially Low-Voltage-Ride-Through (LVRT, has been emphasized, as it is related to tripping in wind farms. Therefore, this paper proposes the Wind power plant applicable-Effective Reactive power Reserve (Wa-ERPR, which combines both wind power plants and conventional generators at the Point of Interconnection (POI. The reactive power capability of the doubly-fed induction generator wind farm was considered to compute the total Wa-ERPR at the POI with reactive power capability of existing generators. By using the Wa-ERPR management algorithm, in case of a violation of the LVRT standards, the amount of reactive power compensation is computed using the Wa-ERPR management scheme. The proposed scheme calculates the Wa-ERPR and computes the required reactive power, reflecting the change of the system topology pre- and post-contingency, to satisfy the LVRT criterion when LVRT regulation is not satisfied at the POI. The static synchronous compensator (STATCOM with the capacity corresponding to calculated amount of reactive power through the Wa-ERPR management scheme is applied to the POI. Therefore, it is confirmed that the wind power plant satisfies the LVRT criteria by securing the appropriate reactive power at the POI, by applying of the proposed algorithm.

  2. Enhancing GIS Capabilities for High Resolution Earth Science Grids

    Science.gov (United States)

    Koziol, B. W.; Oehmke, R.; Li, P.; O'Kuinghttons, R.; Theurich, G.; DeLuca, C.

    2017-12-01

    Applications for high performance GIS will continue to increase as Earth system models pursue more realistic representations of Earth system processes. Finer spatial resolution model input and output, unstructured or irregular modeling grids, data assimilation, and regional coordinate systems present novel challenges for GIS frameworks operating in the Earth system modeling domain. This presentation provides an overview of two GIS-driven applications that combine high performance software with big geospatial datasets to produce value-added tools for the modeling and geoscientific community. First, a large-scale interpolation experiment using National Hydrography Dataset (NHD) catchments, a high resolution rectilinear CONUS grid, and the Earth System Modeling Framework's (ESMF) conservative interpolation capability will be described. ESMF is a parallel, high-performance software toolkit that provides capabilities (e.g. interpolation) for building and coupling Earth science applications. ESMF is developed primarily by the NOAA Environmental Software Infrastructure and Interoperability (NESII) group. The purpose of this experiment was to test and demonstrate the utility of high performance scientific software in traditional GIS domains. Special attention will be paid to the nuanced requirements for dealing with high resolution, unstructured grids in scientific data formats. Second, a chunked interpolation application using ESMF and OpenClimateGIS (OCGIS) will demonstrate how spatial subsetting can virtually remove computing resource ceilings for very high spatial resolution interpolation operations. OCGIS is a NESII-developed Python software package designed for the geospatial manipulation of high-dimensional scientific datasets. An overview of the data processing workflow, why a chunked approach is required, and how the application could be adapted to meet operational requirements will be discussed here. In addition, we'll provide a general overview of OCGIS

  3. A guideline for interpersonal capabilities enhancement to support sustainable facility management practice

    Science.gov (United States)

    Sarpin, Norliana; Kasim, Narimah; Zainal, Rozlin; Noh, Hamidun Mohd

    2018-04-01

    Facility management is the key phase in the development cycle of an assets and spans over a considerable length of time. Therefore, facility managers are in a commanding position to maximise the potential of sustainability through the development phases from construction, operation, maintenance and upgrade leading to decommission and deconstruction. Sustainability endeavours in facility management practices will contribute to reducing energy consumption, waste and running costs. Furthermore, it can also help in improving organisational productivity, financial return and community standing of the organisation. Facility manager should be empowered with the necessary knowledge and capabilities at the forefront facing sustainability challenge. However, literature studies show a gap between the level of awareness, specific knowledge and the necessary skills required to pursue sustainability in the facility management professional. People capability is considered as the key enabler in managing the sustainability agenda as well as being central to the improvement of competency and innovation in an organisation. This paper aims to develop a guidelines for interpersonal capabilities to support sustainability in facility management practice. Starting with a total of 7 critical interpersonal capabilities factors identified from previous questionnaire survey, the authors conducted an interview with 3 experts in facility management to assess the perceived importance of these factors. The findings reveal a set of guidelines for the enhancement of interpersonal capabilities among facility managers by providing what can be done to acquire these factors and how it can support the application of sustainability in their practice. The findings of this paper are expected to form the basis of a mechanism framework developed to equip facility managers with the right knowledge, to continue education and training and to develop new mind-sets to enhance the implementation of sustainability

  4. Stakeholder Capability Enhancement as a Path to Promote Human Dignity and Cooperative Advantage

    NARCIS (Netherlands)

    Westermann-Behaylo, M.K.; Van Buren III, H.J.; Berman, S.L.

    2016-01-01

    Promoting dignity is at the heart of the human capability approach to development. We introduce the concept of stakeholder capability enhancement, beginning with a discussion of the capability approach to development proposed by Sen (1985) and further advanced by Nussbaum (1990) to incorporate

  5. Metallothionein expression in chloroplasts enhances mercury accumulation and phytoremediation capability

    OpenAIRE

    Ruiz, Oscar N.; Alvarez, Derry; Torres, Cesar; Roman, Laura; Daniell, Henry

    2011-01-01

    Genetic engineering to enhance mercury phytoremediation has been accomplished by expression of the merAB genes that protects the cell by converting Hg[II] into Hg[0] which volatilizes from the cell. A drawback of this approach is that toxic Hg is released back into the environment. A better phytoremediation strategy would be to accumulate mercury inside plants for subsequent retrieval. We report here the development of a transplastomic approach to express the mouse metallothionein gene (mt1) ...

  6. End user needs for enhanced IAEA Safeguards Information Management Capabilities

    Energy Technology Data Exchange (ETDEWEB)

    Badalamente, R. [Pacific Northwest Lab., Richland, WA (United States); Anzelon, G. [Lawrence Livermore National Lab., CA (United States); Deland, S. [Sandia National Labs., Albuquerque, NM (United States); Whiteson, R. [Los Alamos National Lab., NM (United States)

    1994-07-01

    The International Atomic Energy Agency is undertaking a program for strengthening its safeguards on the recognition that safeguards must give assurance not only of the non-diversion of declared material or that declared facilities are not being misused, but also of the absence of any undeclared nuclear activities in States which have signed comprehensive safeguards agreements with the Agency. The IAEA has determined that the detection of undeclared nuclear activities and the creation of confidence in the continuing peaceful use of declared material and facilities is largely dependent on more information being made available to the Agency and on the capability of the Agency to make more effective use of this additional information, as well as existing information.

  7. Improving offering strategies for wind farms enhanced with storage capability

    DEFF Research Database (Denmark)

    Ding, Huajie; Hu, Zechun; Song, Yonghua

    2015-01-01

    Due to the flexible charging and discharging capability, energy storage system (ESS) is thought of as a promising complement to wind farms (WF) in participating into electricity markets. This paper proposes a reserve-based real-time operation strategy of ESS to make arbitrage and to alleviate...... the wind power deviation from day-ahead contracts. Taking into account the operation strategy as well as two-price balancing market rules, a day-ahead bidding strategy of WF-ESS system is put forward and formulated. A modified gradient descent algorithm is described to solve the formulations. In the case...... studies, the computational efficiency of the algorithm is validated firstly. Moreover, a number of scenarios with/without considering the temporal dependence of wind power forecast error are designed and employed to compare the proposed strategy with other common ones in terms of profit....

  8. End user needs for enhanced IAEA Safeguards Information Management Capabilities

    International Nuclear Information System (INIS)

    Badalamente, R.; Anzelon, G.; Deland, S.; Whiteson, R.

    1994-07-01

    The International Atomic Energy Agency is undertaking a program for strengthening its safeguards on the recognition that safeguards must give assurance not only of the non-diversion of declared material or that declared facilities are not being misused, but also of the absence of any undeclared nuclear activities in States which have signed comprehensive safeguards agreements with the Agency. The IAEA has determined that the detection of undeclared nuclear activities and the creation of confidence in the continuing peaceful use of declared material and facilities is largely dependent on more information being made available to the Agency and on the capability of the Agency to make more effective use of this additional information, as well as existing information

  9. Parametric Adaptive Radar Detector with Enhanced Mismatched Signals Rejection Capabilities

    Directory of Open Access Journals (Sweden)

    Liu Bin

    2010-01-01

    Full Text Available We consider the problem of adaptive signal detection in the presence of Gaussian noise with unknown covariance matrix. We propose a parametric radar detector by introducing a design parameter to trade off the target sensitivity with sidelobes energy rejection. The resulting detector merges the statistics of Kelly's GLRT and of the Rao test and so covers Kelly's GLRT and the Rao test as special cases. Both invariance properties and constant false alarm rate (CFAR behavior for this detector are studied. At the analysis stage, the performance of the new receiver is assessed and compared with several traditional adaptive detectors. The results highlight better rejection capabilities of this proposed detector for mismatched signals. Further, we develop two two-stage detectors, one of which consists of an adaptive matched filter (AMF followed by the aforementioned detector, and the other is obtained by cascading a GLRT-based Subspace Detector (SD and the proposed adaptive detector. We show that the former two-stage detector outperforms traditional two-stage detectors in terms of selectivity, and the latter yields more robustness.

  10. A workshop on enhanced national capability for neutron scattering

    Energy Technology Data Exchange (ETDEWEB)

    Hurd, Alan J [Los Alamos National Laboratory; Rhyne, James J [Los Alamos National Laboratory; Lewis, Paul S [Los Alamos National Laboratory

    2009-01-01

    This two-day workshop will engage the international neutron scattering community to vet and improve the Lujan Center Strategic Plan 2007-2013 (SP07). Sponsored by the LANL SC Program Office and the University of California, the workshop will be hosted by LANSCE Professor Sunny Sinha (UCSD). Endorsement by the Spallation Neutron Source will be requested. The discussion will focus on the role that the Lujan Center will play in the national neutron scattering landscape assuming full utilization of beamlines, a refurbished LANSCE, and a 1.4-MW SNS. Because the Lujan Strategic Plan is intended to set the stage for the Signature Facility era at LANSCE, there will be some discussion of the long-pulse spallation source at Los Alamos. Breakout groups will cover several new instrument concepts, upgrades to present instruments, expanded sample environment capabilities, and a look to the future. The workshop is in keeping with a request by BES to update the Lujan strategic plan in coordination with the SNS and the broader neutron community. Workshop invitees will be drawn from the LANSCE User Group and a broad cross section of the US, European, and Pacific Rim neutron scattering research communities.

  11. A 16 channel discriminator VME board with enhanced triggering capabilities

    International Nuclear Information System (INIS)

    Borsato, E; Garfagnini, A; Menon, G

    2012-01-01

    Electronics and data acquisition systems used in small and large scale laboratories often have to handle analog signals with varying polarity, amplitude and duration which have to be digitized to be used as trigger signals to validate the acquired data. In the specific case of experiments dealing with ionizing radiation, ancillary particle detectors (for instance plastic scintillators or Resistive Plate Chambers) are used to trigger and select the impinging particles for the experiment. A novel approach using commercial LVDS line receivers as discriminator devices is presented. Such devices, with a proper calibration, can handle positive and negative analog signals in a wide dynamic range (from 20 mV to 800 mV signal amplitude). The clear advantages, with respect to conventional discriminator devices, are reduced costs, high reliability of a mature technology and the possibility of high integration scale. Moreover, commercial discriminator boards with positive input signal and a wide threshold swing are not available on the market. The present paper describes the design and characterization of a VME board capable to handle 16 differential or single-ended input channels. The output digital signals, available independently for each input, can be combined in the board into three independent trigger logic units which provide additional outputs for the end user.

  12. A 16 channel discriminator VME board with enhanced triggering capabilities

    Science.gov (United States)

    Borsato, E.; Garfagnini, A.; Menon, G.

    2012-08-01

    Electronics and data acquisition systems used in small and large scale laboratories often have to handle analog signals with varying polarity, amplitude and duration which have to be digitized to be used as trigger signals to validate the acquired data. In the specific case of experiments dealing with ionizing radiation, ancillary particle detectors (for instance plastic scintillators or Resistive Plate Chambers) are used to trigger and select the impinging particles for the experiment. A novel approach using commercial LVDS line receivers as discriminator devices is presented. Such devices, with a proper calibration, can handle positive and negative analog signals in a wide dynamic range (from 20 mV to 800 mV signal amplitude). The clear advantages, with respect to conventional discriminator devices, are reduced costs, high reliability of a mature technology and the possibility of high integration scale. Moreover, commercial discriminator boards with positive input signal and a wide threshold swing are not available on the market. The present paper describes the design and characterization of a VME board capable to handle 16 differential or single-ended input channels. The output digital signals, available independently for each input, can be combined in the board into three independent trigger logic units which provide additional outputs for the end user.

  13. The ERP capabilities for enhancing the logistic system integration

    OpenAIRE

    Traian Surcel; Razvan Bologa

    2008-01-01

    The increase of companies’ competitiveness as a consequence of globalization and the expansion of the business relations in the web environment requires an approach, in a new dimension, on logistic systems based on a model of arborescent integration of logistic processes, on parallelism of the flows and optimization. Four axes of the integration process had been identified in the research, axes which allow the achievement of these systems interface function between demand side and supply side...

  14. Enhancing the high temperature capability of Ti-alloys

    Energy Technology Data Exchange (ETDEWEB)

    Donchev, Alexander; Schuetze, Michael [DECHEMA-Forschungsinstitut, Frankfurt/Main (Germany); Kolitsch, Andreas; Yankov, Rossen [Helmholtz-Zentrum Dresden-Rossendorf, Institute of Ion Beam Physics and Materials Research, Dresden (Germany)

    2012-08-15

    Titanium is a widely used structural material for applications below approximately 500 C but right now it cannot be used at higher temperatures. Titanium forms a fast growing rutile layer under these conditions. Furthermore enhanced oxygen uptake into the metal subsurface zone leads to embrittlement which deteriorates the mechanical properties. To overcome this problem a combined Al- plus F-treatment was developed. The combination of Al-enrichment in the surface zone so that intermetallic Ti{sub x}Al{sub y}-layers are produced which form a protective alumina layer during high temperature exposure plus stabilization of the Al{sub 2}O{sub 3}-scale by the fluorine effect led to significantly improved resistance against increased oxidation and embrittlement in high temperature exposure tests of several Ti-alloys. In this paper, the experimental procedures and achieved improvements are described. The results will be discussed for the use of Ti-alloys at elevated temperatures. (Copyright copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  15. Metallothionein expression in chloroplasts enhances mercury accumulation and phytoremediation capability.

    Science.gov (United States)

    Ruiz, Oscar N; Alvarez, Derry; Torres, Cesar; Roman, Laura; Daniell, Henry

    2011-06-01

    Genetic engineering to enhance mercury phytoremediation has been accomplished by expression of the merAB genes that protects the cell by converting Hg[II] into Hg[0] which volatilizes from the cell. A drawback of this approach is that toxic Hg is released back into the environment. A better phytoremediation strategy would be to accumulate mercury inside plants for subsequent retrieval. We report here the development of a transplastomic approach to express the mouse metallothionein gene (mt1) and accumulate mercury in high concentrations within plant cells. Real-time PCR analysis showed that up to 1284 copies of the mt1 gene were found per cell when compared with 1326 copies of the 16S rrn gene, thereby attaining homoplasmy. Past studies in chloroplast transformation used qualitative Southern blots to evaluate indirectly transgene copy number, whereas we used real-time PCR for the first time to establish homoplasmy and estimate transgene copy number and transcript levels. The mt1 transcript levels were very high with 183,000 copies per ng of RNA or 41% the abundance of the 16S rrn transcripts. The transplastomic lines were resistant up to 20 μm mercury and maintained high chlorophyll content and biomass. Although the transgenic plants accumulated high concentrations of mercury in all tissues, leaves accumulated up to 106 ng, indicating active phytoremediation and translocation of mercury. Such accumulation of mercury in plant tissues facilitates proper disposal or recycling. This study reports, for the first time, the use of metallothioneins in plants for mercury phytoremediation. Chloroplast genetic engineering approach is useful to express metal-scavenging proteins for phytoremediation. © 2011 The Authors. Plant Biotechnology Journal © 2011 Society for Experimental Biology, Association of Applied Biologists and Blackwell Publishing Ltd.

  16. Lgr5 Identifies Progenitor Cells Capable of Taste Bud Regeneration after Injury.

    Directory of Open Access Journals (Sweden)

    Norifumi Takeda

    Full Text Available Taste buds are composed of a variety of taste receptor cell types that develop from tongue epithelium and are regularly replenished under normal homeostatic conditions as well as after injury. The characteristics of cells that give rise to regenerating taste buds are poorly understood. Recent studies have suggested that Lgr5 (leucine-rich repeat-containing G-protein coupled receptor 5 identifies taste bud stem cells that contribute to homeostatic regeneration in adult circumvallate and foliate taste papillae, which are located in the posterior region of the tongue. Taste papillae in the adult anterior region of the tongue do not express Lgr5. Here, we confirm and extend these studies by demonstrating that Lgr5 cells give rise to both anterior and posterior taste buds during development, and are capable of regenerating posterior taste buds after injury induced by glossopharyngeal nerve transection.

  17. Lgr5 Identifies Progenitor Cells Capable of Taste Bud Regeneration after Injury.

    Science.gov (United States)

    Takeda, Norifumi; Jain, Rajan; Li, Deqiang; Li, Li; Lu, Min Min; Epstein, Jonathan A

    2013-01-01

    Taste buds are composed of a variety of taste receptor cell types that develop from tongue epithelium and are regularly replenished under normal homeostatic conditions as well as after injury. The characteristics of cells that give rise to regenerating taste buds are poorly understood. Recent studies have suggested that Lgr5 (leucine-rich repeat-containing G-protein coupled receptor 5) identifies taste bud stem cells that contribute to homeostatic regeneration in adult circumvallate and foliate taste papillae, which are located in the posterior region of the tongue. Taste papillae in the adult anterior region of the tongue do not express Lgr5. Here, we confirm and extend these studies by demonstrating that Lgr5 cells give rise to both anterior and posterior taste buds during development, and are capable of regenerating posterior taste buds after injury induced by glossopharyngeal nerve transection.

  18. The Capabilities Approach: Fostering contexts for enhancing mental health and wellbeing across the globe.

    Science.gov (United States)

    White, Ross G; Imperiale, Maria Grazia; Perera, Em

    2016-05-05

    Concerted efforts have been made in recent years to achieve equity and equality in mental health for all people across the globe. This has led to the emergence of Global Mental Health as an area of study and practice. The momentum that this has created has contributed to the development, implementation and evaluation of services for priority mental disorders in many low- and middle-income countries.This paper discusses two related issues that may be serving to limit the success of mental health initiatives across the globe, and proposes potential solutions to these issues. First, there has been a lack of sophistication in determining what constitutes a 'good outcome' for people experiencing mental health difficulties. Even though health is defined and understood as a state of 'wellbeing' and not merely an absence of illness, mental health interventions tend to narrowly focus on reducing symptoms of mental illness. The need to also focus more broadly on enhancing subjective wellbeing is highlighted. The second limitation relates to the lack of an overarching theoretical framework guiding efforts to reduce inequalities and inequities in mental health across the globe. This paper discusses the potential impact that the Capabilities Approach (CA) could have for addressing both of these issues. As a framework for human development, the CA places emphasis on promoting wellbeing through enabling people to realise their capabilities and engage in behaviours that they subjectively value. The utilization of the CA to guide the development and implementation of mental health interventions can help Global Mental Health initiatives to identify sources of social inequality and structural violence that may impede freedom and individuals' opportunities to realise their capabilities.

  19. Enhancing the Strategic Capability of the Army: An Investigation of Strategic Thinking Tasks, Skills, and Development

    Science.gov (United States)

    2016-02-01

    Army assignments. Teaching can also help develop visualization skills and innovative thinking through the use of certain teaching methods...required. Some of the specific strategic thinking KSAs built through exposure to complex problems that were mentioned in the interviews were visualization ...Research Report 1995 Enhancing the Strategic Capability of the Army: An Investigation of Strategic Thinking Tasks, Skills

  20. Enhancing Financial Capability and Inclusion in the Philippines : A Demand-Side Survey

    OpenAIRE

    World Bank Group

    2015-01-01

    In response to a request of the Bangko Sentral ng Pilipinas (BSP) and as part of a broader engagement on enhancing financial consumer protection and education in the Philippines, the World Bank has implemented a financial capability survey. Financial inclusion, financial literacy and consumer protection are important priorities for the BSP and the Philippines government. Consumer protectio...

  1. Developing a Dual-Level Capabilities Approach: Using Constructivist Grounded Theory and Feminist Ethnography to Enhance the Capabilities Approaches

    Science.gov (United States)

    Hall, Kia M. Q.

    2014-01-01

    In this study, a dual-level capabilities approach to development is introduced. This approach intends to improve upon individual-focused capabilities approaches developed by Amartya Sen and Martha Nussbaum. Based upon seven months of ethnographic research in the Afro-descendant, autochthonous Garifuna community of Honduras, constructivist grounded…

  2. Available transfer capability evaluation and enhancement using various FACTS controllers: Special focus on system security

    Directory of Open Access Journals (Sweden)

    M. Venkateswara Rao

    2016-03-01

    Full Text Available Nowadays, because of the deregulation of the power industry the continuous increase of the load increases the necessity of calculation of available transfer capability (ATC of a system to analyze the system security. With this calculation, the scheduling of generator can be decided to decrease the system severity. Further, constructing new transmission lines, new substations are very cost effective to meet the increasing load and to increase the transfer capability. Hence, an alternative way to increase the transfer capability is use of flexible ac transmission system (FACTS controllers. In this paper, SSSC, STACOM and UPFC are considered to show the effect of these controllers in enhancing system ATC. For this, a novel current based modeling and optimal location strategy of these controllers are presented. The proposed methodology is tested on standard IEEE-30 bus and IEEE-57 bus test systems with supporting numerical and graphical results.

  3. Establishment of Systematic Design Control/Configuration Management Processes to Enhance Engineering Capability

    International Nuclear Information System (INIS)

    Inagaki, T.; Hamada, T.; Ihara, T.

    2016-01-01

    Full text: After the accident of Fukushima Daiichi Nuclear Power Plant in 2011, Tokyo Electric Power Company (TEPCO) launched various measures to enhance plant safety and safety culture of its employees. One of the important aspects of these measures is to enhance engineering capability and TEPCO is conducting actions to establish systematic design control and configuration management processes as an important foundation of such engineering capability. This paper describes how TEPCO is establishing systematic configuration management processes from three aspects, i.e., design requirement and bases management, facility configuration control, and configuration change management. It also provides brief information of the IT systems that are being introduced and will support the systematic design control and configuration management processes. (author

  4. Models to enhance research capacity and capability in clinical nurses: a narrative review.

    Science.gov (United States)

    O'Byrne, Louise; Smith, Sheree

    2011-05-01

    To identify models used as local initiatives to build capability and capacity in clinical nurses. The National Health Service, Nursing and Midwifery Council and the United Kingdom Clinical Research Collaboration all support the development of the building of research capability and capacity in clinical nurses in the UK. Narrative review. A literature search of databases (including Medline and Pubmed) using the search terms nursing research, research capacity and research capability combined with building, development, model and collaboration. Publications which included a description or methodological study of a structured initiative to tackle research capacity and capability development in clinical nurses were selected. Three models were found to be dominant in the literature. These comprised evidence-based practice, facilitative and experiential learning models. Strong leadership, organisational need and support management were elements found in all three models. Methodological issues were evident and pertain to small sample sizes, inconsistent and poorly defined outcomes along with a lack of data. Whilst the vision of a research ready and active National Health Service is to be applauded to date, there appears to be limited research on the best approach to support local initiatives for nurses that build research capability and capacity. Future studies will need to focus on well-defined objectives and outcomes to enable robust evidence to support local initiatives. To build research capability and capacity in clinical nurses, there is a need to evaluate models and determine the best approach that will provide clinical nurses with research opportunities. © 2010 Blackwell Publishing Ltd.

  5. A Study on Coexistence Capability Evaluations of the Enhanced Channel Hopping Mechanism in WBANs

    Directory of Open Access Journals (Sweden)

    Zhongcheng Wei

    2017-01-01

    Full Text Available As an important coexistence technology, channel hopping can reduce the interference among Wireless Body Area Networks (WBANs. However, it simultaneously brings some issues, such as energy waste, long latency and communication interruptions, etc. In this paper, we propose an enhanced channel hopping mechanism that allows multiple WBANs coexisted in the same channel. In order to evaluate the coexistence performance, some critical metrics are designed to reflect the possibility of channel conflict. Furthermore, by taking the queuing and non-queuing behaviors into consideration, we present a set of analysis approaches to evaluate the coexistence capability. On the one hand, we present both service-dependent and service-independent analysis models to estimate the number of coexisting WBANs. On the other hand, based on the uniform distribution assumption and the additive property of Possion-stream, we put forward two approximate methods to compute the number of occupied channels. Extensive simulation results demonstrate that our estimation approaches can provide an effective solution for coexistence capability estimation. Moreover, the enhanced channel hopping mechanism can significantly improve the coexistence capability and support a larger arrival rate of WBANs.

  6. Identifying extensions required by RUP (Rational Unified Process) to comply with CMM (Capability Maturity Model) levels 2 and 3

    OpenAIRE

    Manzoni, Lisandra Vielmo; Price, Roberto Tom

    2003-01-01

    This paper describes an assessment of the Rational Unified Process (RUP) based on the Capability Maturity Model (CMM). For each key practice (KP) identified in each key process area (KPA) of CMM levels 2 and 3, the Rational Unified Process was assessed to determine whether it satisfied the KP or not. For each KPA, the percentage of the key practices supported was calculated, and the results were tabulated. The report includes considerations about the coverage of each key process area, describ...

  7. EFFECT OF FAMILY EMPOWERMENT IN ENHANCING THE CAPABILITIES OF CHILDREN WITH AUTISM

    Directory of Open Access Journals (Sweden)

    Suprajitno

    2017-10-01

    Full Text Available Background: Children with autism as individuals have a right to receive developmental needs obtained from parent/caregiver during their stay in the family. The family ability can be improved through empowerment training to provide stimulation for the development of children with autism. Objective: This study aims examine the effect of family empowerment in enhancing the capabilities of children with autism. Methods: The research design used a two-stage quasi-experiment. The first stage was a training for parent/caregiver of children with autism using modules. Training was done three times in the Autism Service Center (PLA of Blitar City. The second stage was the parent/caregiver provided stimulation to their children at home. There were 33 children selected using total sampling in the PLA of Blitar City on April – August, 2016. Data were analyzed using descriptive statistics and paired t-test. Results: The family ability to stimulate the capability of children with autism in the sense of hearing, vision, motoric, and inviting to play obtained average changes of 61.99%, with average items increased from 18.52 to 30.00. While the increase capabilities of children with autism were categorized into five classification: communication, fulfilling of activity daily living, language-numbers–tactile, psychology, and understanding commands. Conclusion: There was a significant effect of family empowerment in enhancing the capabilities of children with autism. Thus, training to improve the ability of parent/caregiver in caring children with autism needs to be implemented in a planned and gradually manner.

  8. Enhancing the capabilities of eddy current techniques for non-destructive evaluation of austenitic stainless steels

    International Nuclear Information System (INIS)

    Rao, B.P.C.; Thirunavukkarasu, S.; Sasi, B.; Jayakumar, T.; Baldev Raj

    2010-01-01

    Eddy current non-destructive evaluation (NDE) techniques find many applications during fabrication and in-service inspection of components made of stainless steel. In recent years, concurrent developments in electromagnetic field detection sensors such as giant magneto-resistive (GMR), giant-magneto impedance (GMI) and SQUIDs sensors, computers, microelectronics, and incorporating advanced signal and image processing techniques, have paved the way for enhancing the capabilities of existing eddy current (EC) techniques for examination of austenitic stainless steel (SS) plates, tubes and other geometries and several innovative methodologies have been developed. This paper highlights a few such applications in EC testing to austenitic stainless steel components used in fast reactors. (author)

  9. Trustworthy reconfigurable systems enhancing the security capabilities of reconfigurable hardware architectures

    CERN Document Server

    Feller, Thomas

    2014-01-01

    ?Thomas Feller sheds some light on trust anchor architectures fortrustworthy reconfigurable systems. He is presenting novel concepts enhancing the security capabilities of reconfigurable hardware.Almost invisible to the user, many computer systems are embedded into everyday artifacts, such as cars, ATMs, and pacemakers. The significant growth of this market segment within the recent years enforced a rethinking with respect to the security properties and the trustworthiness of these systems. The trustworthiness of a system in general equates to the integrity of its system components. Hardware-b

  10. Resolved-particle simulation by the Physalis method: Enhancements and new capabilities

    Energy Technology Data Exchange (ETDEWEB)

    Sierakowski, Adam J., E-mail: sierakowski@jhu.edu [Department of Mechanical Engineering, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218 (United States); Prosperetti, Andrea [Department of Mechanical Engineering, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218 (United States); Faculty of Science and Technology and J.M. Burgers Centre for Fluid Dynamics, University of Twente, P.O. Box 217, 7500 AE Enschede (Netherlands)

    2016-03-15

    We present enhancements and new capabilities of the Physalis method for simulating disperse multiphase flows using particle-resolved simulation. The current work enhances the previous method by incorporating a new type of pressure-Poisson solver that couples with a new Physalis particle pressure boundary condition scheme and a new particle interior treatment to significantly improve overall numerical efficiency. Further, we implement a more efficient method of calculating the Physalis scalar products and incorporate short-range particle interaction models. We provide validation and benchmarking for the Physalis method against experiments of a sedimenting particle and of normal wall collisions. We conclude with an illustrative simulation of 2048 particles sedimenting in a duct. In the appendix, we present a complete and self-consistent description of the analytical development and numerical methods.

  11. Design and Research on Platform to Enhance College Students’ Art Appreciation Capability Based on Modern Information Technology

    Directory of Open Access Journals (Sweden)

    Shen Xifei

    2015-01-01

    Full Text Available Nowadays, with the rapid development of modern information technology, the college students could not preferably choose and learn to enhance their own art appreciation capability. Therefore, the colleges and universities have a more urgent desire to organize, develop and provide a good platform to enhance the college students’ art appreciation capability based on modern information technology. This paper describes how to enhance the art appreciation capability in detail, and designs and analyzes the platform to enhance college students’ art appreciation capability based on modern information technology---the “Music Corner” and the “Dance Corner”, indicating that the exchange platform built with modern information technology can promotes the college students’ art appreciation capability. Finally, through the analysis of statistical results of the questionnaire, college students are fonder of art appreciation after the establishment of platform, more inclined to the comprehensive learning of art, more brave to express their own sense of art, and fonder of artistic creation.

  12. Enhanced CANDU 6 (EC6): a proven mid-sized reactor with fuel cycle capability

    International Nuclear Information System (INIS)

    Hopwood, J.; Soulard, M.; Hastings, I.J.

    2011-01-01

    Atomic Energy of Canada (AECL) is finalizing development of the Enhanced CANDU 6 (EC6), which incorporates the CANDU 6's well-proven features, and adds enhancements that make the reactor even more safe and easier to operate. The EC6 is the only mid-sized reactor (700 MWe class) with a proven pedigree that meets modern reactor expectations and regulatory standards. It is sized for smaller grids and also has outstanding fuel-cycle capability. Changes are incremental and consistent with the CANDU 6 project approach. The EC6 utilizes modern computers and a distributed control system housed in an advanced control room which, along with automated testing and on-line diagnostics, make the plant easier and safer to operate, with minimal operator intervention. Containment and seismic capability are upgraded to meet modern standards. The first deployment of the EC6 is anticipated in Canada; international markets are also being pursued. AECL is performing a comprehensive review of the EC6 design in the wake of the Fukushima accident, will review lessons learned, and incorporate any necessary improvements into new build design. (author)

  13. Enhanced CANDU 6 (EC6): a proven mid-sized reactor with fuel cycle capability

    International Nuclear Information System (INIS)

    Hopwood, J.; Soulard, M.; Hastings, I.J.

    2011-01-01

    Atomic Energy of Canada (AECL) is finalizing development of the Enhanced CANDU 6 (EC6), which incorporates the CANDU 6's well-proven features, and enhancements that make the reactor even more safe and easier to operate. The EC6 is the only mid-sized reactor (700 MWe class) with a proven pedigree that meets modern reactor expectations and regulatory standards. It is sized for smaller grids and also has outstanding fuel-cycle capability. Changes are incremental and consistent with the CANDU 6 project approach. The EC6 utilizes modern computers and a distributed control system housed in an advanced control room which, along with automated testing and on-line diagnostics, make the plant easier and safer to operate, with minimal operator intervention. Containment and seismic capability are upgraded to meet modern standards. The first deployment of the EC6 is anticipated in Canada; international markets are also being pursued. AECL is performing a comprehensive review of the EC6 design in the wake of the Fukushima accident, will review lessons learned, and incorporate any necessary improvements into new build design. (author)

  14. Transitioning Enhanced Land Surface Initialization and Model Verification Capabilities to the Kenya Meteorological Department (KMD)

    Science.gov (United States)

    Case, Jonathan L.; Mungai, John; Sakwa, Vincent; Zavodsky, Bradley T.; Srikishen, Jayanthi; Limaye, Ashutosh; Blankenship, Clay B.

    2016-01-01

    Flooding, severe weather, and drought are key forecasting challenges for the Kenya Meteorological Department (KMD), based in Nairobi, Kenya. Atmospheric processes leading to convection, excessive precipitation and/or prolonged drought can be strongly influenced by land cover, vegetation, and soil moisture content, especially during anomalous conditions and dry/wet seasonal transitions. It is thus important to represent accurately land surface state variables (green vegetation fraction, soil moisture, and soil temperature) in Numerical Weather Prediction (NWP) models. The NASA SERVIR and the Short-term Prediction Research and Transition (SPoRT) programs in Huntsville, AL have established a working partnership with KMD to enhance its regional modeling capabilities. SPoRT and SERVIR are providing experimental land surface initialization datasets and model verification capabilities for capacity building at KMD. To support its forecasting operations, KMD is running experimental configurations of the Weather Research and Forecasting (WRF; Skamarock et al. 2008) model on a 12-km/4-km nested regional domain over eastern Africa, incorporating the land surface datasets provided by NASA SPoRT and SERVIR. SPoRT, SERVIR, and KMD participated in two training sessions in March 2014 and June 2015 to foster the collaboration and use of unique land surface datasets and model verification capabilities. Enhanced regional modeling capabilities have the potential to improve guidance in support of daily operations and high-impact weather and climate outlooks over Eastern Africa. For enhanced land-surface initialization, the NASA Land Information System (LIS) is run over Eastern Africa at 3-km resolution, providing real-time land surface initialization data in place of interpolated global model soil moisture and temperature data available at coarser resolutions. Additionally, real-time green vegetation fraction (GVF) composites from the Suomi-NPP VIIRS instrument is being incorporated

  15. Interactive computer-enhanced remote viewing system with data fusion capabilities

    International Nuclear Information System (INIS)

    Walter, T.J.

    1997-01-01

    Robotic missions will increasingly involve sending autonomous and semiautonomous vehicles into unstructured work environments. Mission success will often depend on the ability to accurately map scenes, to combine information from a variety of sensor types, to convey the three-dimensional (3-D) characteristics of these spaces to operators, and to construct geometric model task planning and collision avoidance. To meet these needs, an interactive computer-enhanced remote viewing system (ICERVS) has been developed with general-purpose capabilities for data visualization and geometric modeling. ICERVS has been augmented with software that enables fusing data from multiple mapping sensors and poses to reduce the error effects in individual data sets and improve the mapping accuracy of a work space

  16. Z-Source Inverter Based Power Quality Compensator with Enhanced Ride-Through Capability

    DEFF Research Database (Denmark)

    Gajanayake, C.J.; Vilathgamuwa, D.M.; Loh, P.C.

    2007-01-01

    Distributed generation has been gaining acceptance over the years and it has the potential to provide reliable power to sensitive loads. However, distributed networks are prone to unbalanced faults conditions. This makes single inverter DG systems unsuitable as UPS systems. This paper proposes...... a Zsource inverter based power quality compensator and a control structure that supplies high quality voltage to the connected sensitive load in the presence of other non linear loads. The proposed topology consists of combination of shunt and series inverters connected to a common Z-source impedance...... network. The shunt inverter is controlled to maintain a quality voltage waveform at the load bus. Whereas the series inverter enhances the ride-through capability during grid faults, protects the shunt inverter by limiting the current and also controls the power delivered to the grid. The performance...

  17. Empirical study on the feasibility of measures for public self-protection capability enhancement

    International Nuclear Information System (INIS)

    Goersch, Henning G.; Werner, Ute

    2011-01-01

    The empirical study on the feasibility of measures for public self-protection capability enhancement covers the following issues with several sections: (1) Introduction: scope of the study; structure of the study. (2) Issue coherence: self-protection; reduction and prevention of damage by personal emergency preparedness, personal emergency preparedness in Germany. (3) Solution coherence: scientific approaches, development of practical problem solution approaches, proposal of a promotion system. (4) Empirical studies: Promotion system evaluation by experts; questioning of the public; Delphi-study on minimum standards in emergency preparedness; local networks in emergency preparedness. (5) Evaluation of models for personal emergency preparedness (M3P). (6) Integration of all research results into the approach of emergency preparedness: scope; recommendations, conclusions.

  18. Solvothermal preparation of micro/nanostructured TiO_2 with enhanced lithium storage capability

    International Nuclear Information System (INIS)

    Li, Jie; Wang, Chao; Zheng, Ping; Zhang, Lei; Chen, Gongxuan; Tang, Chengchun; Wu, Tian

    2017-01-01

    Facile and controllable preparation of TiO_2 is of prime importance to elaborately tailor and then fully exploit its intriguing functionalities in energy storage, catalysis and environmental remediation. Herein, a solvothermal method combined with post annealing is conducted, in which the hydrolysis of tetrabutyl titanate is controlled by the in-situ generated water during solvothermal treatment. By controlling synthetic conditions (i.e. reactant ratio, solvothermal temperature and reaction time), we manage to tailor the morphologies of TiO_2. Specially, three typical structures (nanoparticle, nanoneedle and nanorod) are studied to reveal the growth mechanism and the effects of the synthesis conditions. Nanoneedle-structured TiO_2 shows higher specific capacity and enhanced cycle stability as anode material for lithium ion batteries. - Highlights: • Controllable preparation of nano-TiO_2 is achieved by a solvothermal method. • TiO_2 morphology is tailored by tuning reactant ratio, temperature and duration. • Needle structured TiO_2 shows enhanced lithium storage capability.

  19. A novel control strategy for enhancing the LVRT and voltage support capabilities of DFIG

    Science.gov (United States)

    Shen, Yangwu; Zhang, Bin; Liang, Liqing; Cui, Ting

    2018-02-01

    A novel integrated control strategy is proposed in this paper to enhance the low voltage ride through capacity for the double-fed induction generator by equipping an energy storage system. The energy storage system is installed into the DC-link capacitor of the DFIG and used to control the DC-link voltage during normal or transient operations. The energy storage device will absorb or compensate the power difference between the captured wind power and the power injected to the grid during the normal and transient period, and the grid side converter can be free from maintaining the voltage stability of the DC-link capacitor. Thus, the grid-side converter is changed to reactive power support while the rotor-side converter is used to control the maximum power production during normal operation. The grid-side converter and rotor-side converter will act as reactive power sources to further enhance the voltage support capability of double-fed induction generator during the transient period. Numerical Simulation are performed to validate the effectiveness of the proposed control designs.

  20. Enhancements to NASA's Land Atmosphere Near real-time Capability for EOS (LANCE)

    Science.gov (United States)

    Michael, K.; Davies, D. K.; Schmaltz, J. E.; Boller, R. A.; Mauoka, E.; Ye, G.; Vermote, E.; Harrison, S.; Rinsland, P. L.; Protack, S.; Durbin, P. B.; Justice, C. O.

    2016-12-01

    NASA's Land, Atmosphere Near real-time Capability for EOS (LANCE) supports application users interested in monitoring a wide variety of natural and man-made phenomena. Near Real-Time (NRT) data and imagery from the AIRS, AMSR2, MISR, MLS, MODIS, OMI and VIIRS instruments are available much quicker than routine processing allows. Most data products are available within 3 hours from satellite observation. NRT imagery are generally available 3-5 hours after observation. This article describes LANCE and enhancements made to LANCE over the last year. These enhancements include: the addition of MISR L1 Georeferenced Radiance and L2 Cloud Motion Vector products, AMSR2 Unified L2B Half-Orbit 25 km EASE-Grid Surface Soil Moisture products and VIIRS VIIRS Day/Night Band, Land Surface Reflectance and Corrected Surface reflectance products. In addition, the selection of LANCE NRT imagery that can be interactively viewed through Worldview and the Global Imagery Browse Services (GIBS) has been expanded. LANCE is also working to ingest and process data from OMPS.

  1. Solvothermal preparation of micro/nanostructured TiO{sub 2} with enhanced lithium storage capability

    Energy Technology Data Exchange (ETDEWEB)

    Li, Jie [School of Physics and Mechanical & Electronical Engineering, Hubei University of Education, Wuhan, 430205 (China); Wang, Chao [Department of Architecture and Material Engineering, Hubei University of Education, Wuhan, 430205 (China); Zheng, Ping; Zhang, Lei; Chen, Gongxuan [College of Chemistry and Life Science, Hubei University of Education, Wuhan, 430205 (China); Tang, Chengchun [School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130 (China); Wu, Tian, E-mail: twu@whu.edu.cn [School of Physics and Mechanical & Electronical Engineering, Hubei University of Education, Wuhan, 430205 (China); College of Chemistry and Life Science, Hubei University of Education, Wuhan, 430205 (China); Department of Architecture and Material Engineering, Hubei University of Education, Wuhan, 430205 (China)

    2017-04-01

    Facile and controllable preparation of TiO{sub 2} is of prime importance to elaborately tailor and then fully exploit its intriguing functionalities in energy storage, catalysis and environmental remediation. Herein, a solvothermal method combined with post annealing is conducted, in which the hydrolysis of tetrabutyl titanate is controlled by the in-situ generated water during solvothermal treatment. By controlling synthetic conditions (i.e. reactant ratio, solvothermal temperature and reaction time), we manage to tailor the morphologies of TiO{sub 2}. Specially, three typical structures (nanoparticle, nanoneedle and nanorod) are studied to reveal the growth mechanism and the effects of the synthesis conditions. Nanoneedle-structured TiO{sub 2} shows higher specific capacity and enhanced cycle stability as anode material for lithium ion batteries. - Highlights: • Controllable preparation of nano-TiO{sub 2} is achieved by a solvothermal method. • TiO{sub 2} morphology is tailored by tuning reactant ratio, temperature and duration. • Needle structured TiO{sub 2} shows enhanced lithium storage capability.

  2. Developing Alliance Capabilities

    DEFF Research Database (Denmark)

    Heimeriks, Koen H.; Duysters, Geert; Vanhaverbeke, Wim

    This paper assesses the differential performance effects of learning mechanisms on the development of alliance capabilities. Prior research has suggested that different capability levels could be identified in which specific intra-firm learning mechanisms are used to enhance a firm's alliance...

  3. Ultraconservation identifies a small subset of extremely constrained developmental enhancers

    Energy Technology Data Exchange (ETDEWEB)

    Pennacchio, Len A.; Visel, Axel; Prabhakar, Shyam; Akiyama, Jennifer A.; Shoukry, Malak; Lewis, Keith D.; Holt, Amy; Plajzer-Frick, Ingrid; Afzal, Veena; Rubin, Edward M.; Pennacchio, Len A.

    2007-10-01

    While experimental studies have suggested that non-coding ultraconserved DNA elements are central nodes in the regulatory circuitry that specifies mammalian embryonic development, the possible functional relevance of their>200bp of perfect sequence conservation between human-mouse-rat remains obscure 1,2. Here we have compared the in vivo enhancer activity of a genome-wide set of 231 non-exonic sequences with ultraconserved cores to that of 206 sequences that are under equivalently severe human-rodent constraint (ultra-like), but lack perfect sequence conservation. In transgenic mouse assays, 50percent of the ultraconserved and 50percent of the ultra-like conserved elements reproducibly functioned as tissue-specific enhancers at embryonic day 11.5. In this in vivo assay, we observed that ultraconserved enhancers and constrained non-ultraconserved enhancers targeted expression to a similar spectrum of tissues with a particular enrichment in the developing central nervous system. A human genome-wide comparative screen uncovered ~;;2,600 non-coding elements that evolved under ultra-like human-rodent constraint and are similarly enriched near transcriptional regulators and developmental genes as the much smaller number of ultraconserved elements. These data indicate that ultraconserved elements possessing absolute human-rodent sequence conservation are not distinct from other non-coding elements that are under comparable purifying selection in mammals and suggest they are principal constituents of the cis-regulatory framework of mammalian development.

  4. A Decision Support Framework for Feasibility Analysis of International Space Station (ISS) Research Capability Enhancing Options

    Science.gov (United States)

    Ortiz, James N.; Scott,Kelly; Smith, Harold

    2004-01-01

    The assembly and operation of the ISS has generated significant challenges that have ultimately impacted resources available to the program's primary mission: research. To address this, program personnel routinely perform trade-off studies on alternative options to enhance research. The approach, content level of analysis and resulting outputs of these studies vary due to many factors, however, complicating the Program Manager's job of selecting the best option. To address this, the program requested a framework be developed to evaluate multiple research-enhancing options in a thorough, disciplined and repeatable manner, and to identify the best option on the basis of cost, benefit and risk. The resulting framework consisted of a systematic methodology and a decision-support toolset. The framework provides quantifiable and repeatable means for ranking research-enhancing options for the complex and multiple-constraint domain of the space research laboratory. This paper describes the development, verification and validation of this framework and provides observations on its operational use.

  5. CORONA ACADEMY, Opportunities for Enhancement of Training Capabilities in VVER Technology

    International Nuclear Information System (INIS)

    Ilieva, M.; Dieguez Porras, P.; Klepakova, A.

    2016-01-01

    Full text: The general objective of the project CORONA II is to enhance the safety of nuclear installations through further improvement of the training capabilities for providing the necessary personnel competencies in VVER area. More specific objective of the project is to continue the development of a state-of-the-art regional training network for VVER competence called CORONA Academia. The project aims at continuation of the European cooperation and support in this area for preservation and further development of expertise in the nuclear field by improvement of higher education and training. The consortium is focusing its effort on using the most advanced ways of providing training to the trainees, saving cost and time–distance learning and e-learning approaches which will be tested in CORONA II Project. The knowledge management portal will integrate the information on VVER web into a single communication system and develop and implement a semantic web structure to achieve mutual recognition of authentication information with other databases. That will enable the partners to share the materials available in each specific training center. (author

  6. Data Compatibility to Enhance Sustainable Capabilities for Autonomous Analytics in IoT

    Directory of Open Access Journals (Sweden)

    Kaleem Razzaq Malik

    2017-05-01

    Full Text Available The collection of raw data is based on sensors embedded in devices or the environment for real-time data extraction. Nowadays, the Internet of Things (IoT environment is used to support autonomous data collection by reducing human involvement. It is hard to analyze such data, especially when working with the sensors in a real-time environment. On using data analytics in IoT with the help of RDF, many issues can be resolved. Resultant data will have a better chance of quality analytics by reforming data into the semantical annotation. Industrial correspondence through data will be improved by the induction of semantics at large due to efficient data capturing, whereas one popular medium of sensors’ data storage is Relational Database (RDB. This study provides a complete automated mechanism to transform from loosely structured data stored in RDB into RDF. These data are obtained from sensors in semantically annotated RDF stores. The given study comprises methodology for improving compatibility by introducing bidirectional transformation between classical DB and RDF data stores to enhance the sustainable capabilities of IoT systems for autonomous analytics. Two case studies, one on weather and another on heart-rate measurement collections through IoT sensors, are used to show the transformation process in operation.

  7. Enhancement of Pre-and Post-Processing Capability of the CUPID code

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jongtae; Park, Ik Kyu; Yoon, Hanyoung [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-05-15

    To simulate heat transfer and fluid flow in a field with a complicated geometry, an unstructured mesh is popularly used. Most commercial CFD (Computational Fluid Dynamics) solvers are based on an unstructured mesh technology. An advantage of using unstructured meshes for a field simulation is reduced man-hours by automatic mesh generation compared to a traditional structured mesh generation, which requires a huge amount of man-hours to discretized a complex geometry. Initially, unstructured meshes that can be generated automatically are limited to regular cell elements such as tetrahedron, pyramid, prism, or hexahedron. The multi-dimensional multi-phase flow solver, CUPID, has been developed in the context of an unstructured mesh finite volume method (FVM). Its numerical formulation and programming structure is independent of the number of faces surrounding the computational cells. Thus, it can be easily extended into polyhedral unstructured meshes. In this study, new tools for enhancing the pre- and post-processing capabilities of CUPID are proposed. They are based on an open-source CFD tool box OpenFOAM. A goal of this study is an extension of the applicability of the CUPID code by improving the mesh and solution treatment of the code.

  8. NSR&D FY17 Report: CartaBlanca Capability Enhancements

    Energy Technology Data Exchange (ETDEWEB)

    Long, Christopher Curtis [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Dhakal, Tilak Raj [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Zhang, Duan Zhong [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-10-19

    Over the last several years, particle technology in the CartaBlanca code has been matured and has been successfully applied to a wide variety of physical problems. It has been shown that the particle methods, especially Los Alamos's dual domain material point method, is capable of computing many problems involves complex physics, chemistries accompanied by large material deformations, where the traditional finite element or Eulerian method encounter significant difficulties. In FY17, the CartaBlanca code has been enhanced with physical models and numerical algorithms. We started out to compute penetration and HE safety problems. Most of the year we focused on the TEPLA model improvement testing against the sweeping wave experiment by Gray et al., because it was found that pore growth and material failure are essentially important for our tasks and needed to be understood for modeling the penetration and the can experiments efficiently. We extended the TEPLA mode from the point view of ensemble phase average to include the effects of nite deformation. It is shown that the assumed pore growth model in TEPLA is actually an exact result from the theory. Alone this line, we then generalized the model to include finite deformations to consider nonlinear dynamics of large deformation. The interaction between the HE product gas and the solid metal is based on the multi-velocity formation. Our preliminary numerical results suggest good agreement between the experiment and the numerical results, pending further verification. To improve the parallel processing capabilities of the CartaBlanca code, we are actively working with the Next Generation Code (NGC) project to rewrite selected packages using C++. This work is expected to continue in the following years. This effort also makes the particle technology developed with CartaBlanca project available to other part of the laboratory. Working with the NGC project and rewriting some parts of the code also given us an

  9. A Lactobacillus mutant capable of accumulating long-chain polyphosphates that enhance intestinal barrier function.

    Science.gov (United States)

    Saiki, Asako; Ishida, Yasuaki; Segawa, Shuichi; Hirota, Ryuichi; Nakamura, Takeshi; Kuroda, Akio

    2016-05-01

    Inorganic polyphosphate (polyP) was previously identified as a probiotic-derived substance that enhances intestinal barrier function. PolyP-accumulating bacteria are expected to have beneficial effects on the human gastrointestinal tract. In this study, we selected Lactobacillus paracasei JCM 1163 as a strain with the potential to accumulate polyP, because among the probiotic bacteria stored in our laboratory, it had the largest amount of polyP. The chain length of polyP accumulated in L. paracasei JCM 1163 was approximately 700 phosphate (Pi) residues. L. paracasei JCM 1163 accumulated polyP when Pi was added to Pi-starved cells. We further improved the ability of L. paracasei JCM 1163 to accumulate polyP by nitrosoguanidine mutagenesis. The mutant accumulated polyP at a level of 1500 nmol/mg protein-approximately 190 times that of the wild-type strain. PolyP extracted from the L. paracasei JCM 1163 significantly suppressed the oxidant-induced intestinal permeability in mouse small intestine. In conclusion, we have succeeded in breeding the polyP-accumulating Lactobacillus mutant that is expected to enhance intestinal barrier function.

  10. Cost-effective way to enhance the capabilities of the LCLS baseline

    Energy Technology Data Exchange (ETDEWEB)

    Geloni, Gianluca [European XFEL GmbH, Hamburg (Germany); Kocharyan, Vitali; Saldin, Evgeni [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2010-08-15

    This paper discusses the potential for enhancing the LCLS hard X-ray FEL capabilities. In the hard X-ray regime, a high longitudinal coherence will be the key to such performance upgrade. The method considered here to obtain high longitudinal coherence is based on a novel single-bunch self-seeding scheme exploiting a single crystal monochromator, which is extremely compact and can be straightforwardly installed in the LCLS baseline undulator. We present simulation results dealing with the LCLS hard X-ray FEL, and show that this method can produce fully-coherent X-ray pulses at 100 GW power level. With the radiation beam monochromatized down to the Fourier transform limit, a variety of very different techniques leading to further improvements of the LCLS performance become feasible. In particular, we describe an efficient way for obtaining full polarization control at the LCLS hard X-ray FEL. We also propose to exploit crystals in the Bragg reflection geometry as movable deflectors for the LCLS X-ray transport systems. The hard X-ray beam can be deflected of an angle of order of a radian without perturbations. The monochromatization of the output radiation constitutes the key for reaching such result. Finally, we describe a newoptical pump - hard X-ray probe technique which will allow time-resolved studies at the LCLS baseline on the femtosecond time scale. The principle of operation of the proposed scheme is essentially based on the use of the time jitter between pump and probe pulses. This eliminates the need for timing XFELs to high-power conventional lasers with femtosecond accuracy. (orig.)

  11. Cost-effective way to enhance the capabilities of the LCLS baseline

    International Nuclear Information System (INIS)

    Geloni, Gianluca; Kocharyan, Vitali; Saldin, Evgeni

    2010-08-01

    This paper discusses the potential for enhancing the LCLS hard X-ray FEL capabilities. In the hard X-ray regime, a high longitudinal coherence will be the key to such performance upgrade. The method considered here to obtain high longitudinal coherence is based on a novel single-bunch self-seeding scheme exploiting a single crystal monochromator, which is extremely compact and can be straightforwardly installed in the LCLS baseline undulator. We present simulation results dealing with the LCLS hard X-ray FEL, and show that this method can produce fully-coherent X-ray pulses at 100 GW power level. With the radiation beam monochromatized down to the Fourier transform limit, a variety of very different techniques leading to further improvements of the LCLS performance become feasible. In particular, we describe an efficient way for obtaining full polarization control at the LCLS hard X-ray FEL. We also propose to exploit crystals in the Bragg reflection geometry as movable deflectors for the LCLS X-ray transport systems. The hard X-ray beam can be deflected of an angle of order of a radian without perturbations. The monochromatization of the output radiation constitutes the key for reaching such result. Finally, we describe a newoptical pump - hard X-ray probe technique which will allow time-resolved studies at the LCLS baseline on the femtosecond time scale. The principle of operation of the proposed scheme is essentially based on the use of the time jitter between pump and probe pulses. This eliminates the need for timing XFELs to high-power conventional lasers with femtosecond accuracy. (orig.)

  12. Enhancement of Training Capabilities in VVER Technology Through Establishment of VVER Training Academy

    International Nuclear Information System (INIS)

    Ilieva, M.; Miteva, R.

    2015-01-01

    Education and training (E&T) have always been key factor to the sustainability of the nuclear industry. With regard to E&T it is still the challenge to raise the interest of qualified young people of studies and professions related to nuclear technologies. CORONA Project is established to provide a special purpose structure for training and for gathering the existing and generating new knowledge in the VVER area as well as to contribute to transnational mobility and lifelong learning amongst VVER operating countries. CORONA Project consists of two parts: CORONA I (2011–2014) “Establishment of a regional centre of competence for VVER technology and Nuclear Applications”, co-financed by the EC Framework Programme 7 and CORONA II “Enhancement of training capabilities in VVER technology through establishment of VVER training academy”, co-financed by the EURATOM 2014-2015 Working programme of HORIZON 2020. The project is focused on development of training schemes for VVER nuclear professionals, subcontractors, students and for non-nuclear specialists working in support of nuclear applications as civil engineers, physical protection employees, government employees, secondary school teachers, journalists. Safety culture and soft skills training are incorporated as an integral part of all training schemes because they require continuous consideration. It is vital for the acceptance of nuclear energy by the public and for the safe performance of the nuclear installations. CORONA II project is to proceed with the development of state-of-the-art virtual training centre — CORONA Academy. This objective will be realised through networking between universities, research organizations, regulatory bodies, industry and any other organizations involved in the application of nuclear science, ionising radiation and nuclear safety. It will bring together the most experienced trainers and will allow trainees from different locations to access the needed knowledge on demand

  13. Using HEC-RAS to Enhance Interpretive Capabilities of Geomorphic Assessments

    Science.gov (United States)

    Keefer, L. L.

    2005-12-01

    The purpose of a geomorphic assessment is to characterize and evaluate a fluvial system for determining the past watershed and channel conditions, current geomorphic character and potential future channel adjustments. The geomorphic assessment approach utilized by the Illinois State Water Survey assesses channel response to disturbance at multiple temporal and spatial scales to help identify the underlying factors and events which led to the existing channel morphology. This is accomplished through two phases of investigation that involve a historical and physical analysis of the watershed, disturbance history, and field work at increasing levels of detail. To infer future channel adjustments, the geomorphic assessment protocol combines two methods of analyses that are dependent on the quantity and detail of the available data. The first method is the compilation of multiple lines of evidence using qualitative information related to the dominant fluvial environment, channel gradient, stream power thresholds, and channel evolution models. The second method is the use of hydraulic models which provide additional interpretative skills to evaluate potential channel adjustments. The structured data collection framework of the geomorphic assessment approach is used for the development of a HEC-RAS model. The model results are then used as another tool to determine the influence of bridges and control structures on channel stability, stream power profiles to identify potential channel bed degradation zones, and provide data for physically-based bank stability models. This poster will demonstrate the advantages of using a hydraulic model, such as HEC-RAS, to expand the interpretive capabilities of geomorphic assessments. The results from applying this approach will be demonstrated for the Big Creek watershed of the Cache River Basin in southern Illinois.

  14. Research on enhancement of natural circulation capability in lead–bismuth alloy cooled reactor by using gas-lift pump

    Energy Technology Data Exchange (ETDEWEB)

    Zuo, Juanli, E-mail: Jenyzuo@163.com; Tian, Wenxi, E-mail: wxtian@mail.xjtu.edu.cn; Chen, Ronghua, E-mail: ronghua.chen@stu.xjtu.edu.cn; Qiu, Suizheng; Su, Guanghui, E-mail: ghsu@mail.xjtu.edu.cn

    2013-10-15

    Highlights: • The gas-lift pump has been adopted to enhance the natural circulation capability. • LENAC code is developed in my study. • The calculation results by LENAC code show good agreement with experiment results. • Gas mass flow rate, bubble diameter, rising pipe length are important parameters. -- Abstract: The gas-lift pump has been adopted to enhance the natural circulation capability in the type of lead–bismuth alloy cooled reactors such as Accelerator Driven System (ADS) and Liquid–metal Fast Reactor (LMFR). The natural circulation ability and the system safety are obviously influenced by the two phase flow characteristics of liquid metal–inert gas. In this study, LENAC (LEad bismuth alloy NAtural Circulation capability) code has been developed to evaluate the natural circulation capability of lead–bismuth cooled ADS with gas-lift pump. The drift flow theory, void fraction prediction model and friction pressure drop prediction model have been incorporated into LENAC code. The calculation results by LENAC code show good agreement with experiment results of CIRCulation Experiment (CIRCE) facility. The effects of the gas mass flow rate, void fraction, gas quality, bubble diameter and the rising pipe height or the potential difference between heat exchanger and reactor core on natural circulation capability of gas-lift pump have been analyzed. The results showed that in bubbly flow pattern, for a fixed value of gas mass flow rate, the natural circulation capability increased with the decrease of the bubble diameter. In the bubbly flow, slug flow, churn flow and annular flow pattern, with the gas mass flow rate increasing, the natural circulation capability initially increased and then declined. And the flow parameters influenced the thermal hydraulic characteristics of the reactor core significantly. The present work is helpful for revealing the law of enhancing the natural circulation capability by gas-lift pump, and providing theoretical

  15. How the unique configuration of the human head may enhance flavor perception capabilities: an evolutionary perspective

    Directory of Open Access Journals (Sweden)

    Daniel E Lieberman

    2014-07-01

    Full Text Available Since flavor derives from the synthesis of taste, somatosensation and smell, one of the most important factors in the ability to perceive flavor is retronasal olfaction in which volatile compounds pass from the oral cavity through the pharynx to the olfactory epithelium. Retronasal olfaction has been documented in both humans and rodents, but appears less effective in rodents than orthonasal olfaction because expired air does not come into as much contact with the sensory neurons in the olfactory epithelium as inspired air [1,2]. Detailed comparisons of retronasal airflow patterns among different species have not been conducted, but several lines of evidence lead to the hypothesis that retronasal airflow may be specially enhanced in humans because of four derived features of the human head and neck that evolved at different stages because of selection for functions other than olfaction [3]. If so, then human flavor perception capabilities may be more derived than is commonly appreciated, and perhaps played a role in selecting for the evolution of cooking. The first derived adaptation that aids human retronasal olfaction is the absence of the transverse lamina, a horizontal shelf of bone that partitions the olfactory chamber of the nasal fossa from the more inferior respiratory passage. This lamina, which is present in most mammals, was lost during the evolution of monkeys (haplorhines from more primitive primates (strepsirhines as part of a reorganization of the nasal cavity. The function of the transverse lamina has not been tested but it probably aids orthonasal olfaction by trapping inspired air in the olfactory region. Loss of the transverse lamina is commonly interpreted to be one of several trade-offs in primate evolution that favored vision over olfaction [4], but it likely benefits retronasal olfaction by permitting a direct pathway for expired air to flow towards the olfactory epithelium. A second derived adaptation present in humans is

  16. Enhancement of the lithium cycling capability using Li–Zn alloy substrate for lithium metal batteries

    International Nuclear Information System (INIS)

    Chen, Chen; Yang, Yifu; Shao, Huixia

    2014-01-01

    Graphical abstract: - Highlights: • Li-Zn alloy substrate is novelly formed by Li electrodeposition on the Zn substrate precursor. • The coulombic efficiency of Li deposition/stripping on the Li-Zn alloy substrate remains high at 96.7% after 400 cycles. • The SEI film formed during the formation of Li-Zn alloy is stable during Li deposition/stripping cycling on the Li-Zn substrate. • The exchange current density of Li deposition on the Li-Zn substrate is 9.21 × 10 −4 A cm −2 which is nearly eight times larger than that on the Cu substrate. - Abstract: The cycling performance of a Li metal electrode in rechargeable Li batteries is studied using a novelly formed Li–Zn alloy as a substrate. A Zn layer electrodeposited on a Cu disk with ultrasonic assistance is used as a substrate precursor. Li electrodeposition followed to form the Li–Zn alloy. The morphologies of the substrate before and after Li deposition and stripping are investigated by scanning electron microscopy (SEM), and the electrochemical properties of the substrate are investigated by galvanostatic charge-discharge and cyclic voltammetry (CV). The growth states of solid electrolyte interface (SEI) films of Li deposits on the Li–Zn alloy and Cu surfaces are compared by electrochemical impedance spectroscopy (EIS); exchange current densities of Li electrodeposition on Cu, Zn, and Li–Zn alloy substrates are also compared based on tests of constant current pulse deposition. The efficiency of Li deposition/stripping on the Li–Zn alloy substrate remains high at 96.7% after 400 cycles at a current density of 0.1 mA cm −2 and 250 cycles at the current density of 0.2 mA cm −2 . These results can be attributed to the formation of a stable SEI film on the Li–Zn substrate and the high exchange current density of Li deposition and stripping on this substrate. The Li–Zn alloy proposed in this work may be a perfect substrate for enhancing the cycling capability of Li metal electrode

  17. Identify High-Quality Protein Structural Models by Enhanced K-Means.

    Science.gov (United States)

    Wu, Hongjie; Li, Haiou; Jiang, Min; Chen, Cheng; Lv, Qiang; Wu, Chuang

    2017-01-01

    Background. One critical issue in protein three-dimensional structure prediction using either ab initio or comparative modeling involves identification of high-quality protein structural models from generated decoys. Currently, clustering algorithms are widely used to identify near-native models; however, their performance is dependent upon different conformational decoys, and, for some algorithms, the accuracy declines when the decoy population increases. Results. Here, we proposed two enhanced K -means clustering algorithms capable of robustly identifying high-quality protein structural models. The first one employs the clustering algorithm SPICKER to determine the initial centroids for basic K -means clustering ( SK -means), whereas the other employs squared distance to optimize the initial centroids ( K -means++). Our results showed that SK -means and K -means++ were more robust as compared with SPICKER alone, detecting 33 (59%) and 42 (75%) of 56 targets, respectively, with template modeling scores better than or equal to those of SPICKER. Conclusions. We observed that the classic K -means algorithm showed a similar performance to that of SPICKER, which is a widely used algorithm for protein-structure identification. Both SK -means and K -means++ demonstrated substantial improvements relative to results from SPICKER and classical K -means.

  18. The Enhancement of Regional Disaster Management Agencies (BPBD of Sumbawa Regency’s Capability in Flash Flood Management Through Aid Assistance of Japan International Cooperation Agency (JICA

    Directory of Open Access Journals (Sweden)

    Nudia Vebina Ayumahani

    2018-03-01

    Full Text Available The need for enhancing capability has a very important significance in effective disaster management activities. Regional Disaster Management Agencies (BPBD of Sumbawa Regency established cooperation with the Japan International Cooperation Agency (JICA in enhancing the capability of flash flood management. The purpose of this research was to review and evaluate the JICA’s aid assistance programs toward BPBD of Sumbawa Regency, hereafter analyze the impact of the programs. Evaluation and analysis of this research were measured by three indicators of capability which is resources, leadership and policy implementation. This research used a qualitative descriptive method and proceed through the source and method triangulation. The researcher used purposive sampling technique in choosing seven informants from BPBD of Sumbawa Regency’s staff. The results showed that JICA’s aid assistance programs towards BPBD of Sumbawa Regency had been achieved by the targets and goals that have been determined. This program has impacted on enhancing the capability of resources that leads to the ability in Mapping, Technical Guidelines (JUKNIS and Disaster Management Plan (RPB. Increasing the capability of Human Resources (HR gives the effect of increasing capability in other fields such as financial resource capability, technical resource capability, leadership capability and policy implementation capability. The main factors in the success of the capability enhancement are the discipline factor of BPBD staff, high willingness to improve capability by BPBD staff, capability- enhancing programs, and clear direction from JICA.

  19. An Enhanced GINGER Simulation Code with Harmonic Emission and HDF5 IO Capabilities

    International Nuclear Information System (INIS)

    Fawley, William M.

    2006-01-01

    GINGER [1] is an axisymmetric, polychromatic (r-z-t) FEL simulation code originally developed in the mid-1980's to model the performance of single-pass amplifiers. Over the past 15 years GINGER's capabilities have been extended to include more complicated configurations such as undulators with drift spaces, dispersive sections, and vacuum chamber wakefield effects; multi-pass oscillators; and multi-stage harmonic cascades. Its coding base has been tuned to permit running effectively on platforms ranging from desktop PC's to massively parallel processors such as the IBM-SP. Recently, we have made significant changes to GINGER by replacing the original predictor-corrector field solver with a new direct implicit algorithm, adding harmonic emission capability, and switching to the HDF5 IO library [2] for output diagnostics. In this paper, we discuss some details regarding these changes and also present simulation results for LCLS SASE emission at λ = 0.15 nm and higher harmonics

  20. Enhanced Rate Capability of Oxide Coated Lithium Titanate within Extended Voltage Ranges

    Energy Technology Data Exchange (ETDEWEB)

    Ahn, Dongjoon [College of Engineering, University of Kentucky, Lexington, KY (United States); Xiao, Xingcheng, E-mail: xingcheng.xiao@gm.com [Chemical and Materials Systems Laboratory, General Motors R& D Center, Warren, MI (United States)

    2015-06-30

    Lithium titanate (Li{sub 4}Ti{sub 5}O{sub 12} or LTO) is a promising negative electrode material of high-power lithium-ion batteries, due to its superior rate capability and excellent capacity retention. However, the specific capacity of LTO is less than one half of that of graphite electrode. In this work, we applied ultrathin oxide coating on LTO by the atomic layer deposition technique, aiming for increasing the energy density by extending the cell voltage window and specific capacity of LTO. We demonstrated that a few nanometer thick Al{sub 2}O{sub 3} coating can suppress the mechanical distortion of LTO cycled at low potential, which enable the higher specific capacity and excellent capacity retention. Furthermore, the surface coating can facilitate the charge transfer, leading to significantly improved rate capabilities, comparing with the uncoated LTO.

  1. The upgraded cold neutron triple-axis spectrometer FLEXX – enhanced capabilities by new instrumental options

    Directory of Open Access Journals (Sweden)

    Habicht Klaus

    2015-01-01

    Full Text Available The upgrade of the cold neutron triple axis spectrometer FLEXX, a work-horse instrument for inelastic neutron scattering matching the sample environment capabilities at Helmholtz-Zentrum Berlin, has been successfully accomplished. Experiments confirmed an order of magnitude gain in flux now allowing for intensity demanding options to be fully exploited at FLEXX. In this article, we describe the layout and design of two newly available FLEXX instrument options in detail. The new Heusler analyzer gives an increase of the detected polarized neutron flux due to its superior focusing properties, significantly improving the feasibility of future polarized and neutron resonance spin echo experiments. The MultiFLEXX option provides simultaneous access to large regions in wavevector and energy space for inelastic excitations thus adding mapping capabilities to the spectrometer.

  2. Specificity and Strain-Typing Capabilities of Nanorod Array-Surface Enhanced Raman Spectroscopy for Mycoplasma pneumoniae Detection.

    Directory of Open Access Journals (Sweden)

    Kelley C Henderson

    Full Text Available Mycoplasma pneumoniae is a cell wall-less bacterial pathogen of the human respiratory tract that accounts for > 20% of all community-acquired pneumonia (CAP. At present the most effective means for detection and strain-typing is quantitative polymerase chain reaction (qPCR, which can exhibit excellent sensitivity and specificity but requires separate tests for detection and genotyping, lacks standardization between available tests and between labs, and has limited practicality for widespread, point-of-care use. We have developed and previously described a silver nanorod array-surface enhanced Raman Spectroscopy (NA-SERS biosensing platform capable of detecting M. pneumoniae with statistically significant specificity and sensitivity in simulated and true clinical throat swab samples, and the ability to distinguish between reference strains of the two main genotypes of M. pneumoniae. Furthermore, we have established a qualitative lower endpoint of detection for NA-SERS of < 1 genome equivalent (cell/μl and a quantitative multivariate detection limit of 5.3 ± 1 cells/μl. Here we demonstrate using partial least squares- discriminatory analysis (PLS-DA of sample spectra that NA-SERS correctly identified M. pneumoniae clinical isolates from globally diverse origins and distinguished these from a panel of 12 other human commensal and pathogenic mycoplasma species with 100% cross-validated statistical accuracy. Furthermore, PLS-DA correctly classified by strain type all 30 clinical isolates with 96% cross-validated accuracy for type 1 strains, 98% cross-validated accuracy for type 2 strains, and 90% cross-validated accuracy for type 2V strains.

  3. Enhancing the LVRT Capability of PMSG-Based Wind Turbines Based on R-SFCL

    Science.gov (United States)

    Xu, Lin; Lin, Ruixing; Ding, Lijie; Huang, Chunjun

    2018-03-01

    A novel low voltage ride-through (LVRT) scheme for PMSG-based wind turbines based on the Resistor Superconducting Fault Current Limiter (R-SFCL) is proposed in this paper. The LVRT scheme is mainly formed by R-SFCL in series between the transformer and the Grid Side Converter (GSC), and basic modelling has been discussed in detail. The proposed LVRT scheme is implemented to interact with PMSG model in PSCAD/EMTDC under three phase short circuit fault condition, which proves that the proposed scheme based on R-SFCL can improve the transient performance and LVRT capability to consolidate grid connection with wind turbines.

  4. Enhanced EOS photovoltaic power system capability with InP solar cells

    Science.gov (United States)

    Bailey, Sheila G.; Weinberg, Irving; Flood, Dennis J.

    1991-01-01

    The Earth Observing System (EOS), which is part of the International Mission to Planet Earth, is NASA's main contribution to the Global Change Research Program which opens a new era in international cooperation to study the Earth's environment. Five large platforms are to be launched into polar orbit, two by NASA, two by ESA, and one by the Japanese. In such an orbit the radiation resistance of indium phosphide solar cells combined with the potential of utilizing five micron cell structures yields an increase of 10 percent in the payload capability. If further combined with the advanced photovoltaic solar array the payload savings approaches 12 percent.

  5. A Novel Laccase from Ganoderma Lucidum Capable of Enhancing Enzymatic Degradation of Lignocellulolytic Biomass

    DEFF Research Database (Denmark)

    2014-01-01

    for the hydrolysis of biomass using a laccase derived from Ganoderma lucidum. Further, the invention provides an enzyme composition comprising a laccase derived from Ganoderma lucidum which may be combined with one or more cellulases, and for its use in enhancing lignocellulose biomass hydrolysis....

  6. Molecular characterization of whey protein hydrolysate fractions with ferrous chelating and enhanced iron solubility capabilities.

    Science.gov (United States)

    O'Loughlin, Ian B; Kelly, Phil M; Murray, Brian A; FitzGerald, Richard J; Brodkorb, Andre

    2015-03-18

    The ferrous (Fe2+) chelating capabilities of WPI hydrolysate fractions produced via cascade membrane filtration were investigated, specifically 1 kDa permeate (P) and 30 kDa retentate (R) fractions. The 1 kDa-P possessed a Fe2+ chelating capability at 1 g L(-1) equivalent to 84.4 μM EDTA (for 30 kDa-R the value was 8.7 μM EDTA). Fourier transformed infrared (FTIR) spectroscopy was utilized to investigate the structural characteristics of hydrolysates and molecular interactions with Fe2+. Solid-phase extraction was employed to enrich for chelating activity; the most potent chelating fraction was enriched in histidine and lysine. The solubility of ferrous sulfate solutions (10 mM) over a range of pH values was significantly (Piron solubility was improved by 72% in the presence of the 1 kDa-P fraction following simulated gastrointestinal digestion (SGID) compared to control FeSO4·7H2O solutions.

  7. Fault Ride-Through Capability Enhancement of VSC HVDC connected Offshore Wind Power Plants

    DEFF Research Database (Denmark)

    Sharma, Ranjan; Wu, Qiuwei; Cha, Seung-Tae

    2015-01-01

    This paper presents a feed forward direct current (DC) voltage control based fault ride-through (FRT) scheme for voltage source converter (VSC) high voltage DC (HVDC) connected offshore wind power plants (WPPs) in order to achieve active control of the WPP collector network AC voltage magnitude......, and to improve the FRT capability. During steady state operation, an open loop AC voltage control is implemented at the WPP side VSC of the HVDC system such that any possible control interactions between the WPP side VSC and the wind turbine VSC are minimized. Whereas during any grid faults, a dynamic AC voltage...... reference is applied based on both the DC voltage error and the AC active-current from the WPP collector system which ensures fast and robust FRT of the VSC HVDC connected offshore WPPs. Under unbalanced fault conditions in the host power system, the resulting oscillatory DC voltage is directly used...

  8. Strontium doped lanthanum manganite/manganese dioxide composite electrode for supercapacitor with enhanced rate capability

    International Nuclear Information System (INIS)

    Lv, Jingbo; Zhang, Yaohui; Lv, Zhe; Huang, Xiqiang; Wang, Zhihong; Zhu, Xingbao; Wei, Bo

    2016-01-01

    (La 0.75 Sr 0.25 ) 0.95 MnO 3-δ (LSM)/MnO 2 composite for supercapacitor (SC) electrode is successfully synthesized via a facile hydrothermal method. The LSM/MnO 2 composite shows a flower-like structure and possesses numerous active sites and better conductivity. The as-prepared LSM/MnO 2 electrode exhibits a larger specific capacitance of 437.2 F g −1 , much better than that of pure MnO 2 . Furthermore, the composite electrode also has a higher rate capability (capacitance improvement can reach to 70%) and better cycling stability. It is believed that the present results provide an efficient electrode materials design and a novel composite for the future practical application of high-performance supercapacitor.

  9. Enhancing sample preparation capabilities for accelerator mass spectrometry radiocarbon and radiocalcium studies

    International Nuclear Information System (INIS)

    Taylor, R.E.

    1991-01-01

    With support provided by the LLNL Accelerator Mass Spectrometry Laboratory, the UCR Radiocarbon Laboratory continued its studies involving sample pretreatment and target preparation for both AMS radiocarbon ( 14 C) and radiocalcium ( 41 Ca) involving applications to archaeologically -- and paleoanthropologically- related samples. With regard to AMS 14 C-related studies, we have extended the development of a series of procedures which have, as their initial goal, the capability to combust several hundred microgram amounts of a chemically-pretreated organic sample and convert the resultant CO 2 to graphitic carbon which will consistently yield relatively high 13 C - ion currents and blanks which will yield, on a consistent basis, 14 C count rates at or below 0.20% modern, giving an 2 sigma age limit of >50,000 yr BP

  10. Design of hierarchical CuS/graphene architectures with enhanced lithium storage capability

    Energy Technology Data Exchange (ETDEWEB)

    Ding, Caihua; Su, Dezhi [Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications, School of Materials Science & Engineering, Beijing Institute of Technology, Beijing, 100081 (China); Ma, Wenxian [State Key Laboratory for Advanced Metals and Materials, University of Science and Technology Beijing, Beijing, 100083 (China); Zhao, Yongjie, E-mail: zhaoyjpeace@gmail.com [Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications, School of Materials Science & Engineering, Beijing Institute of Technology, Beijing, 100081 (China); Yan, Dong [Department of Mechanical Engineering, Tsinghua University, Beijing, 100084 (China); State Key Laboratory of Tribology, Tsinghua University, Beijing, 100084 (China); Li, Jingbo; Jin, Haibo [Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications, School of Materials Science & Engineering, Beijing Institute of Technology, Beijing, 100081 (China)

    2017-05-01

    Highlights: • A delicate route was proposed for rational design of CuS/graphene composite. • Hierarchical CuS was composed of large amounts of well-arranged nanosheets. • The rationally designed structure of composite offered stable-hosts for Li{sup +} insertion. • The graphene constructed conductive paths and a network for fast transport of Li{sup +}. • The presence of the graphene in the composite reduced the dissolution of polysulfides. - Abstract: Metal-sulfides electrode materials usually suffer from poor cyclability and low rate capability in rechargeable batteries as a result of the pulverization of active materials and the loss of sulfur material induced by polysulfide dissolution. Herein, we reported a delicate and scalable route for rational design of CuS/graphene composites. Hierarchical CuS microparticles comprising of large amounts of self-assembled and well-arranged nanosheets uniformly mixed with flexible graphene layers. The obtained CuS/graphene electrodes exhibited high specific capacities, excellent cycling stability and desirable rate capability when being evaluated as anode materials for lithium-ion batteries. The high specific capacities of 568 mA h g{sup −1} after 100 cycles at 50 mA g{sup −1} and 143 mA h g{sup −1} at 1000 mA g{sup −1} (in rate testing) were achieved, suggesting a very promising candidate for high-performance lithium-ion batteries. The rationally designed structures of the CuS/graphene composites offered stable-hosts for Li{sup +} insertion and alleviated the volume changes upon cycling. The presence of the graphene in composite not only constructed conductive paths and a network for fast transport of Li{sup +}, but also effectively reduced the dissolution of polysulfides into electrolyte. This graphene-based composite with hierarchical structure could be used as a safe, low-cost, and versatile material for extensively potential applications.

  11. Design of hierarchical CuS/graphene architectures with enhanced lithium storage capability

    International Nuclear Information System (INIS)

    Ding, Caihua; Su, Dezhi; Ma, Wenxian; Zhao, Yongjie; Yan, Dong; Li, Jingbo; Jin, Haibo

    2017-01-01

    Highlights: • A delicate route was proposed for rational design of CuS/graphene composite. • Hierarchical CuS was composed of large amounts of well-arranged nanosheets. • The rationally designed structure of composite offered stable-hosts for Li + insertion. • The graphene constructed conductive paths and a network for fast transport of Li + . • The presence of the graphene in the composite reduced the dissolution of polysulfides. - Abstract: Metal-sulfides electrode materials usually suffer from poor cyclability and low rate capability in rechargeable batteries as a result of the pulverization of active materials and the loss of sulfur material induced by polysulfide dissolution. Herein, we reported a delicate and scalable route for rational design of CuS/graphene composites. Hierarchical CuS microparticles comprising of large amounts of self-assembled and well-arranged nanosheets uniformly mixed with flexible graphene layers. The obtained CuS/graphene electrodes exhibited high specific capacities, excellent cycling stability and desirable rate capability when being evaluated as anode materials for lithium-ion batteries. The high specific capacities of 568 mA h g −1 after 100 cycles at 50 mA g −1 and 143 mA h g −1 at 1000 mA g −1 (in rate testing) were achieved, suggesting a very promising candidate for high-performance lithium-ion batteries. The rationally designed structures of the CuS/graphene composites offered stable-hosts for Li + insertion and alleviated the volume changes upon cycling. The presence of the graphene in composite not only constructed conductive paths and a network for fast transport of Li + , but also effectively reduced the dissolution of polysulfides into electrolyte. This graphene-based composite with hierarchical structure could be used as a safe, low-cost, and versatile material for extensively potential applications.

  12. Contrast Enhanced Ultrasound of the Kidneys: What Is It Capable of?

    Directory of Open Access Journals (Sweden)

    Demosthenes D. Cokkinos

    2013-01-01

    Full Text Available One of the many imaging uses of contrast enhanced ultrasound (CEUS is studying a wide variety of kidney pathology, due to its ability to detect microvascular blood flow in real time without affecting renal function. CEUS enables dynamic assessment and quantification of microvascularisation up to capillary perfusion. The objective of this paper is to briefly refresh basic knowledge of ultrasound (US contrast agents’ physical properties, to study technical details of CEUS scanning in the kidneys, and to review the commonest renal indications for CEUS, with imaging examples in comparison to baseline unenhanced US and computed tomography when performed. Safety matters and limitations of CEUS of the kidneys are also discussed.

  13. Time-over-threshold readout to enhance the high flux capabilities of single-photon-counting detectors

    International Nuclear Information System (INIS)

    Bergamaschi, Anna; Dinapoli, Roberto; Greiffenberg, Dominic; Henrich, Beat; Johnson, Ian; Mozzanica, Aldo; Radicci, Valeria; Schmitt, Bernd; Shi, Xintian; Stoppani, Laura

    2011-01-01

    The MYTHEN photon-counting ASIC operated in time-over-threshold mode shows an innovative approach towards the development of a detector operating with very high photon intensities while maintaining the single-photon sensitivity for synchrotron radiation experiments. The MYTHEN single-photon-counting (SPC) detector has been characterized using the time-over-threshold (ToT) readout method, i.e. measuring the time that the signal produced by the detected X-rays remains above the comparator threshold. In the following it is shown that the ToT readout preserves the sensitivity, dynamic range and capability of background suppression of the SPC mode, while enhancing the count-rate capability, which is the main limitation of state-of-the-art SPC systems

  14. Time-over-threshold readout to enhance the high flux capabilities of single-photon-counting detectors

    Energy Technology Data Exchange (ETDEWEB)

    Bergamaschi, Anna, E-mail: anna.bergamaschi@psi.ch; Dinapoli, Roberto; Greiffenberg, Dominic; Henrich, Beat; Johnson, Ian; Mozzanica, Aldo; Radicci, Valeria; Schmitt, Bernd; Shi, Xintian; Stoppani, Laura [Paul Scherrer Institut, CH-5232 Villigen (Switzerland)

    2011-11-01

    The MYTHEN photon-counting ASIC operated in time-over-threshold mode shows an innovative approach towards the development of a detector operating with very high photon intensities while maintaining the single-photon sensitivity for synchrotron radiation experiments. The MYTHEN single-photon-counting (SPC) detector has been characterized using the time-over-threshold (ToT) readout method, i.e. measuring the time that the signal produced by the detected X-rays remains above the comparator threshold. In the following it is shown that the ToT readout preserves the sensitivity, dynamic range and capability of background suppression of the SPC mode, while enhancing the count-rate capability, which is the main limitation of state-of-the-art SPC systems.

  15. Enhancing AP1000 reactor accident management capabilities for long term accidents

    International Nuclear Information System (INIS)

    Jiang Pingting; Liu Mengying; Duan Chengjie; Liao Yehong

    2015-01-01

    Passive safety actions are considered as main measures under severe accident in AP1000 power plant. However, risk is still existed. According to PSA, several probable scenarios for AP1000 nuclear power plant are analyzed in this paper with MAAP the severe accident analysis code. According to the analysis results, several deficiencies of AP1000 severe accident management are found. The long term cooling and containment depressurization capability for AP1000 power plant appear to be most important factors under such accidents. Then, several temporary strategies for AP1000 power plant are suggested, including PCCWST temporary water supply strategy after 72h, temporary injection strategy for IRWST, hydrogen relief action in fuel building, which would improve the safety of AP1000 power plant. At last, assessments of effectiveness for these strategies are performed, and the results are compared with analysis without these strategies. The comparisons showed that correct actions of these strategies would effectively prevent the accident process of AP1000 power plant. (author)

  16. Enhancing Interoperability and Capabilities of Earth Science Data using the Observations Data Model 2 (ODM2

    Directory of Open Access Journals (Sweden)

    Leslie Hsu

    2017-02-01

    Full Text Available Earth Science researchers require access to integrated, cross-disciplinary data in order to answer critical research questions. Partially due to these science drivers, it is common for disciplinary data systems to expand from their original scope in order to accommodate collaborative research. The result is multiple disparate databases with overlapping but incompatible data. In order to enable more complete data integration and analysis, the Observations Data Model Version 2 (ODM2 was developed to be a general information model, with one of its major goals to integrate data collected by 'in situ' sensors with those by 'ex-situ' analyses of field specimens. Four use cases with different science drivers and disciplines have adopted ODM2 because of benefits to their users. The disciplines behind the four cases are diverse – hydrology, rock geochemistry, soil geochemistry, and biogeochemistry. For each case, we outline the benefits, challenges, and rationale for adopting ODM2. In each case, the decision to implement ODM2 was made to increase interoperability and expand data and metadata capabilities. One of the common benefits was the ability to use the flexible handling and comprehensive description of specimens and data collection sites in ODM2’s sampling feature concept. We also summarize best practices for implementing ODM2 based on the experience of these initial adopters. The descriptions here should help other potential adopters of ODM2 implement their own instances or to modify ODM2 to suit their needs.

  17. Fluorescent genetic barcoding in mammalian cells for enhanced multiplexing capabilities in flow cytometry.

    Science.gov (United States)

    Smurthwaite, Cameron A; Hilton, Brett J; O'Hanlon, Ryan; Stolp, Zachary D; Hancock, Bryan M; Abbadessa, Darin; Stotland, Aleksandr; Sklar, Larry A; Wolkowicz, Roland

    2014-01-01

    The discovery of the green fluorescent protein from Aequorea victoria has revolutionized the field of cell and molecular biology. Since its discovery a growing panel of fluorescent proteins, fluorophores and fluorescent-coupled staining methodologies, have expanded the analytical capabilities of flow cytometry. Here, we exploit the power of genetic engineering to barcode individual cells with genes encoding fluorescent proteins. For genetic engineering, we utilize retroviral technology, which allows for the expression of ectopic genetic information in a stable manner in mammalian cells. We have genetically barcoded both adherent and nonadherent cells with different fluorescent proteins. Multiplexing power was increased by combining both the number of distinct fluorescent proteins, and the fluorescence intensity in each channel. Moreover, retroviral expression has proven to be stable for at least a 6-month period, which is critical for applications such as biological screens. We have shown the applicability of fluorescent barcoded multiplexing to cell-based assays that rely themselves on genetic barcoding, or on classical staining protocols. Fluorescent genetic barcoding gives the cell an inherited characteristic that distinguishes it from its counterpart. Once cell lines are developed, no further manipulation or staining is required, decreasing time, nonspecific background associated with staining protocols, and cost. The increasing number of discovered and/or engineered fluorescent proteins with unique absorbance/emission spectra, combined with the growing number of detection devices and lasers, increases multiplexing versatility, making fluorescent genetic barcoding a powerful tool for flow cytometry-based analysis. © 2013 International Society for Advancement of Cytometry.

  18. VESUVIO. A project to provide enhanced neutron scattering capabilities at the highest energy transfers

    International Nuclear Information System (INIS)

    Tomkinson, J.; Bowden, Z.A.; Mayers, J.; Norris, J.; Rhodes, N.J.; Colognesi, D.; Fielding, A.L.; Praitano, M.

    1999-01-01

    Complete text of publication follows. The VESUVIO project is financed within the TMR-Access to Large Scale Facility (RTD project) of the European Community. It will provide unique prototype instrumentation at the ISIS neutron source which will build on the success and experience of the eVS spectrometer in measuring single particle dynamics of a wide range of condensed matter systems. The instrumentation is designed for high momentum (20A -1 -1 ) and energy (ℎω>1eV) transfer inelastic neutron scattering studies of microscopic dynamical properties such as, single particle kinetic energies and momentum distributions. Specific objectives are: a) to optimize and construct a high efficiency, high area detector, 6 Li doped scintillator glasses are being tested; b) to construct a sample tank capable of operating with either a cold, or room temperature, filter analyzers; c) to develop new electronics and data acquisition to handle the high count-rates which will be generated in the azimuthal detectors. Some examples of applications performed during the first year of the project will be presented. (author)

  19. An application of zeta potential method for the selection of nano-fluids to enhance IVR capability

    International Nuclear Information System (INIS)

    Pham Quynh Trang; Kim, Tae Il; Chang, Soon Heung

    2009-01-01

    In-vessel Retention (IVR) is one of the key severe accident management strategies that have been applied currently for advanced light water reactors such as APR1000 or APR1400. The concept of IVR consists of external cooling of the reactor vessel by flooding the reactor cavity to remove the decay heat from the molten core through the lower head of the vessel. However, the heat removal process is limited by the occurrence of critical heat flux (CHF) at the reactor vessel outer surface that may lead to a sharp increase of local temperature, damaging the integrity of the reactor vessel. In order to obtain higher power of nuclear reactors and to assure the achievement of the IVR capability during accident conditions, an enhancement of CHF at the outer surface of the vessel is required. The potential use of nano-fluids to increase the CHF is among the main IVR enhancing approaches. In this study, Al 2 O 3 and CNT nano-fluids with different concentrations have been used as the potential coolant to enhance IVR capabilities. The dispersion stability of the nano-fluids was verified by zeta potential measurements. The results showed effects of time, concentration and pH on the stability of nanofluids. Three types of nano-fluids were selected as the candidates to apply for the IVR. A series of experiments have been performed in this study to understand the pool-boiling critical heat flux behavior on downward facing surfaces submerged in a pool of nano-fluids at very low concentration. The inclination angle was changed from horizontal to vertical to investigate the effect of orientation on CHF enhancement which is needed for the application in IVR

  20. NTR-Enhanced Lunar-Base Supply using Existing Launch Fleet Capabilities

    Energy Technology Data Exchange (ETDEWEB)

    John D. Bess; Emily Colvin; Paul G. Cummings

    2009-06-01

    During the summer of 2006, students at the Center for Space Nuclear Research sought to augment the current NASA lunar exploration architecture with a nuclear thermal rocket (NTR). An additional study investigated the possible use of an NTR with existing launch vehicles to provide 21 metric tons of supplies to the lunar surface in support of a lunar outpost. Current cost estimates show that the complete mission cost for an NTR-enhanced assembly of Delta-IV and Atlas V vehicles may cost 47-86% more than the estimated Ares V launch cost of $1.5B; however, development costs for the current NASA architecture have not been assessed. The additional cost of coordinating the rendezvous of four to six launch vehicles with an in-orbit assembly facility also needs more thorough analysis and review. Future trends in launch vehicle use will also significantly impact the results from this comparison. The utility of multiple launch vehicles allows for the development of a more robust and lower risk exploration architecture.

  1. NTR-Enhanced Lunar-Base Supply using Existing Launch Fleet Capabilities

    International Nuclear Information System (INIS)

    Bess, John D.; Colvin, Emily; Cummings, Paul G.

    2009-01-01

    During the summer of 2006, students at the Center for Space Nuclear Research sought to augment the current NASA lunar exploration architecture with a nuclear thermal rocket (NTR). An additional study investigated the possible use of an NTR with existing launch vehicles to provide 21 metric tons of supplies to the lunar surface in support of a lunar outpost. Current cost estimates show that the complete mission cost for an NTR-enhanced assembly of Delta-IV and Atlas V vehicles may cost 47-86% more than the estimated Ares V launch cost of $1.5B; however, development costs for the current NASA architecture have not been assessed. The additional cost of coordinating the rendezvous of four to six launch vehicles with an in-orbit assembly facility also needs more thorough analysis and review. Future trends in launch vehicle use will also significantly impact the results from this comparison. The utility of multiple launch vehicles allows for the development of a more robust and lower risk exploration architecture

  2. Comparison of capability of dynamic O2-enhanced MRI and quantitative thin-section MDCT to assess COPD in smokers

    International Nuclear Information System (INIS)

    Ohno, Yoshiharu; Koyama, Hisanobu; Yoshikawa, Takeshi; Matsumoto, Keiko; Aoyama, Nobukazu; Onishi, Yumiko; Takenaka, Daisuke; Matsumoto, Sumiaki; Nishimura, Yoshihiro; Sugimura, Kazuro

    2012-01-01

    Purpose: The purpose of this study was to directly and prospectively compare the capability of dynamic O 2 -enhanced MRI and quantitatively assessed thin-section MDCT to assess smokers’ COPD in a large prospective cohort. Materials and methods: The GOLD criteria for smokers were used to classify 187 smokers into four clinical stage groups as follows: smokers without COPD (n = 56) and with mild (n = 54), moderate (n = 52) and severe or very severe COPD (n = 24). All smokers underwent dynamic O 2 -enhanced MRI, MDCT and pulmonary function tests. Mean relative enhancement ratio and mean wash-in time on MRI and CT-based functional lung volume (CT-based FLV) as well as the ratio of airway wall area to total airway area on MDCT were computationally calculated. Then, all indexes were significantly correlated with functional parameters. To determine the efficacy of all indexes for clinical stage classification, the indexes for the four clinical groups were statistically compared by using Tukey's honestly significant difference multiple comparison test. Results: All indexes had significant correlations with functional parameters (p 2 -enhanced MRI for assessment of COPD in smokers is potentially as efficacious as quantitatively assessed thin-section MDCT.

  3. Laser fabrication of Ag-HA nanocomposites on Ti6Al4V implant for enhancing bioactivity and antibacterial capability

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Xiangmei; Man, H.C., E-mail: mfhcman@polyu.edu.hk

    2017-01-01

    For titanium alloy implants, both surface bioactivity and antibacterial infection are the two critical factors in determining the success of clinical implantation of these metallic implants. In the present work, a novel nanocomposite layer of nano-silver-containing hydroxyapatite (Ag-HA) was prepared on the surface of biomedical Ti6Al4V by laser processing. Analysis using SEM, EDS and XRD shows the formation of an Ag-HA layer of about 200 μm fusion bonded to the substrate. Mineralization tests in simulated body fluid (SBF) showed that laser fabricated Ag-HA nanocomposite layer favors the deposition of apatite on the surface of the implants. Antibacterial tests confirmed that all Ag-HA nanocomposite layers can kill bacteria while a higher Ag content would lower the cytocompatibility of these coatings. Cell viability decreases when the Ag content reaches 5% in these coatings, due to the larger amount of Ag leached out, as confirmed by ion release evaluation. Our results reveal that laser fabricated Ag-HA nanocomposite coatings containing 2% Ag show both excellent cytocompatibility and antibacterial capability. - Highlights: • Silver-containing hydroxyapatite (Ag-HA) nanocomposite layer was fabricated on Ti6Al4V by laser technique. • Both bioactivity and antibacterial capability were significantly enhanced compared with bare Ti6Al4V. • Ag-HA nanocomposite coatings containing 2% Ag show both excellent cytocompatibility and antibacterial capability.

  4. Diagnostic capability of scanning laser polarimetry with and without enhanced corneal compensation and optical coherence tomography.

    Science.gov (United States)

    Benítez-del-Castillo, Javier; Martinez, Antonio; Regi, Teresa

    2011-01-01

    To compare the abilities of the current commercially available versions of scanning laser polarimetry (SLP) and optical coherence tomography (OCT), SLP-variable corneal compensation (VCC), SLP-enhanced corneal compensation (ECC), and high-definition (HD) OCT, in discriminating between healthy eyes and those with early-to-moderate glaucomatous visual field loss. Healthy volunteers and patients with glaucoma who met the eligibility criteria were consecutively enrolled in this prospective, cross-sectional, observational study. Subjects underwent complete eye examination, automated perimetry, SLP-ECC, SLP-VCC, and HD-OCT. Scanning laser polarimetry parameters were recalculated in 90-degree segments (quadrants) in the calculation circle to be compared. Areas under the receiver operating characteristic curve (AUROCs) were calculated for every parameter in order to compare the ability of each imaging modality to differentiate between normal and glaucomatous eyes. Fifty-five normal volunteers (mean age 59.1 years) and 33 patients with glaucoma (mean age 63.8 years) were enrolled. Average visual field mean deviation was -6.69 dB (95% confidence interval -8.07 to -5.31) in the glaucoma group. The largest AUROCs were associated with nerve fiber indicator (0.880 and 0.888) for the SLP-VCC and SLP-ECC, respectively, and with the average thickness in the HD-OCT (0.897). The best performing indices for the SLP-VCC, SLP-ECC, and HD OCT gave similar AUROCs, showing moderate diagnostic accuracy in patients with early to moderate glaucoma. Further studies are needed to evaluate the ability of these technologies to discriminate between normal and glaucomatous eyes.

  5. Electrode design optimization of lithium secondary batteries to enhance adhesion and deformation capabilities

    International Nuclear Information System (INIS)

    Jeong, Dongho; Lee, Jongsoo

    2014-01-01

    Safety, performance and lifetime of LSB (lithium secondary batteries) are affected by the adhesion of the active material to the electrode substance, and to the electrode deformation and the spring back limit in the electrode manufacturing process. This study explores the optimization process using decision tree analysis, an ANN (artificial neural network), and a multi-objective genetic algorithm. In the electrode design optimization, the objectives are to maximize the adhesion and to minimize the electrode deformation subjected to the allowable limit on the spring-back. Experimental data for use in design analysis and optimization is obtained via a measurement test. The decision tree analysis is first performed to extract major, effective parameters sensitive to adhesion force, electrode deformation and spring-back. The ANN-based approximate meta-models are then established for function approximations. The ANN-based causality analysis is further explored to determine dominant design variables for each of three design requirements for the optimization. A multi-objective optimization is finally conducted using ANN-based approximate meta-models. An optimized solution obtained from the numerical optimization process is compared with experimental data to verify the actual performance of the LSB in terms of physical and electro-chemical properties. - Highlights: • Electrode design for enhancing adhesion and electrode deformation performances. • Maximizing adhesion and minimizing deformation with allowable limit on spring-back. • Extraction of effective design parameters from data mining techniques. • Numerical optimization using experimental data of lithium secondary batteries. • Comparison of an optimized solution with an experimental result

  6. Enhanced drug delivery capabilities from stents coated with absorbable polymer and crystalline drug.

    Science.gov (United States)

    Carlyle, Wenda C; McClain, James B; Tzafriri, Abraham R; Bailey, Lynn; Zani, Brett G; Markham, Peter M; Stanley, James R L; Edelman, Elazer R

    2012-09-28

    Current drug eluting stent (DES) technology is not optimized with regard to the pharmacokinetics of drug delivery. A novel, absorbable-coating sirolimus-eluting stent (AC-SES) was evaluated for its capacity to deliver drug more evenly within the intimal area rather than concentrating drug around the stent struts and for its ability to match coating erosion with drug release. The coating consisted of absorbable poly-lactide-co-glycolic acid (PLGA) and crystalline sirolimus deposited by a dry-powder electrostatic process. The AC-SES demonstrated enhanced drug stability under simulated use conditions and consistent drug delivery balanced with coating erosion in a porcine coronary implant model. The initial drug burst was eliminated and drug release was sustained after implantation. The coating was absorbed within 90 days. Following implantation into porcine coronary arteries the AC-SES coating is distributed in the surrounding intimal tissue over the course of several weeks. Computational modeling of drug delivery characteristics demonstrates how distributed coating optimizes the load of drug immediately around each stent strut and extends drug delivery between stent struts. The result was a highly efficient arterial uptake of drug with superior performance to a clinical bare metal stent (BMS). Neointimal thickness (0.17±0.07 mm vs. 0.28±0.11 mm) and area percent stenosis (22±9% vs. 35±12%) were significantly reduced (pstent implantation in an overlap configuration in porcine coronary arteries. Inflammation was significantly reduced in the AC-SES compared to the BMS at both 30 and 90 days after implantation. Biocompatible, rapidly absorbable stent coatings enable the matching of drug release with coating erosion and provide for the controlled migration of coating material into tissue to reduce vicissitudes in drug tissue levels, optimizing efficacy and reducing potential toxicity. Copyright © 2012 Elsevier B.V. All rights reserved.

  7. Extending i-line capabilities through variance characterization and tool enhancement

    Science.gov (United States)

    Miller, Dan; Salinas, Adrian; Peterson, Joel; Vickers, David; Williams, Dan

    2006-03-01

    Continuous economic pressures have moved a large percent of integrated device manufacturing (IDM) operations either overseas or to foundry operations over the last 10 years. These pressures have left the IDM fabs in the U.S. with required COO improvements in order to maintain operations domestically. While the assets of many of these factories are at a very favorable point in the depreciation life cycle, the equipment and processes are constrained to the quality of the equipment in its original state and the degradation over its installed life. With the objective to enhance output and improve process performance, this factory and their primary lithography process tool supplier have been able to extend the usable life of the existing process tools, increase the output of the tool base, and improve the distribution of the CDs on the product produced. Texas Instruments Incorporated lead an investigation with the POLARIS ® Systems & Services business of FSI International to determine the sources of variance in the i-line processing of a wide array of IC device types. Data from the sources of variance were investigated such as PEB temp, PEB delay time, develop recipe, develop time, and develop programming. While PEB processes are a primary driver of acid catalyzed resists, the develop mode is shown in this work to have an overwhelming impact on the wafer to wafer and across wafer CD performance of these i-line processes. These changes have been able to improve the wafer to wafer CD distribution by more than 80 %, and the within wafer CD distribution by more than 50 % while enabling a greater than 50 % increase in lithography cluster throughput. The paper will discuss the contribution from each of the sources of variance and their importance in overall system performance.

  8. Power Quality Improvement and LVRT Capability Enhancement of Wind Farms by Means of an Inductive Filtering Method

    Directory of Open Access Journals (Sweden)

    Yanjian Peng

    2016-04-01

    Full Text Available Unlike the traditional method for power quality improvement and low-voltage ride through (LVRT capability enhancement of wind farms, this paper proposes a new wind power integrated system by means of an inductive filtering method, especially if it contains a grid-connected transformer, a static synchronous compensator (STATCOM and fully-tuned (FT branches. First, the main circuit topology of the new wind power integrated system is presented. Then, the mathematical model is established to reveal the mechanism of harmonic suppression and the reactive compensation of the proposed wind power integrated system, and then the realization conditions of the inductive filtering method is obtained. Further, the control strategy of STATCOM is introduced. Based on the measured data for a real wind farm, the simulation studies are carried out to illustrate the performance of the proposed new wind power integrated system. The results indicate that the new system can not only enhance the LVRT capability of wind farms, but also prevent harmonic components flowing into the primary (grid winding of the grid-connected transformer. Moreover, since the new method can compensate for reactive power in a wind farm, the power factor at the grid side can be improved effectively.

  9. Overexpression of Insulin-Like Growth Factor 1 Enhanced the Osteogenic Capability of Aging Bone Marrow Mesenchymal Stem Cells.

    Science.gov (United States)

    Chen, Ching-Yun; Tseng, Kuo-Yun; Lai, Yen-Liang; Chen, Yo-Shen; Lin, Feng-Huei; Lin, Shankung

    2017-01-01

    Many studies have indicated that loss of the osteoblastogenic potential in bone marrow mesenchymal stem cells (bmMSCs) is the major component in the etiology of the aging-related bone deficit. But how the bmMSCs lose osteogenic capability in aging is unclear. Using 2-dimentional cultures, we examined the dose response of human bmMSCs, isolated from adult and aged donors, to exogenous insulin-like growth factor 1 (IGF-1), a growth factor regulating bone formation. The data showed that the mitogenic activity and the osteoblastogenic potential of bmMSCs in response to IGF-1 were impaired with aging, whereas higher doses of IGF-1 increased the proliferation rate and osteogenic potential of aging bmMSCs. Subsequently, we seeded IGF-1-overexpressing aging bmMSCs into calcium-alginate scaffolds and incubated in a bioreactor with constant perfusion for varying time periods to examine the effect of IGF-1 overexpression to the bone-forming capability of aging bmMSCs. We found that IGF-1 overexpression in aging bmMSCs facilitated the formation of cell clusters in scaffolds, increased the cell survival inside the cell clusters, induced the expression of osteoblast markers, and enhanced the biomineralization of cell clusters. These results indicated that IGF-1 overexpression enhanced cells' osteogenic capability. Thus, our data suggest that the aging-related loss of osteogenic potential in bmMSCs can be attributed in part to the impairment in bmMSCs' IGF-1 signaling, and support possible application of IGF-1-overexpressing autologous bmMSCs in repairing bone defect of the elderly and in producing bone graft materials for repairing large scale bone injury in the elderly.

  10. Novel scheme for enhancement of fault ride-through capability of doubly fed induction generator based wind farms

    International Nuclear Information System (INIS)

    Vinothkumar, K.; Selvan, M.P.

    2011-01-01

    Research highlights: → Proposed Fault ride-through (FRT) scheme for DFIG is aimed at energy conservation. → The input mechanical energy is stored during fault and utilized at fault clearance. → Enhanced Rotor speed stability of DFIG. → Reduced Reactive power requirement and rapid voltage recovery at fault clearance. → Improved post fault performance of DFIG at fault clearance. -- Abstract: Enhancement of fault ride-through (FRT) capability and subsequent improvement of rotor speed stability of wind farms equipped with doubly fed induction generator (DFIG) is the objective of this paper. The objective is achieved by employing a novel FRT scheme with suitable control strategy. The proposed FRT scheme, which is connected between the rotor circuit and dc link capacitor in parallel with Rotor Side Converter, consists of an uncontrolled rectifier, two sets of IGBT switches, a diode and an inductor. In this scheme, the input mechanical energy of the wind turbine during grid fault is stored and utilized at the moment of fault clearance, instead of being dissipated in the resistors of the crowbar circuit as in the existing FRT schemes. Consequently, torque balance between the electrical and mechanical quantities is achieved and hence the rotor speed deviation and electromagnetic torque fluctuations are reduced. This results in reduced reactive power requirement and rapid reestablishment of terminal voltage on fault clearance. Furthermore, the stored electromagnetic energy in the inductor is transferred into the dc link capacitor on fault clearance and hence the grid side converter is relieved from charging the dc link capacitor, which is very crucial at this moment, and this converter can be utilized to its full capacity for rapid restoration of terminal voltage and normal operation of DFIG. Extensive simulation study carried out employing PSCAD/EMTDC software vividly demonstrates the potential capabilities of the proposed scheme in enhancing the performance of

  11. Novel scheme for enhancement of fault ride-through capability of doubly fed induction generator based wind farms

    Energy Technology Data Exchange (ETDEWEB)

    Vinothkumar, K. [Department of Electrical and Electronics Engineering, National Institute of Technology, Tiruchirappalli, Tamilnadu 620015 (India); Selvan, M.P., E-mail: selvanmp@nitt.ed [Department of Electrical and Electronics Engineering, National Institute of Technology, Tiruchirappalli, Tamilnadu 620015 (India)

    2011-07-15

    Research highlights: {yields} Proposed Fault ride-through (FRT) scheme for DFIG is aimed at energy conservation. {yields} The input mechanical energy is stored during fault and utilized at fault clearance. {yields} Enhanced Rotor speed stability of DFIG. {yields} Reduced Reactive power requirement and rapid voltage recovery at fault clearance. {yields} Improved post fault performance of DFIG at fault clearance. -- Abstract: Enhancement of fault ride-through (FRT) capability and subsequent improvement of rotor speed stability of wind farms equipped with doubly fed induction generator (DFIG) is the objective of this paper. The objective is achieved by employing a novel FRT scheme with suitable control strategy. The proposed FRT scheme, which is connected between the rotor circuit and dc link capacitor in parallel with Rotor Side Converter, consists of an uncontrolled rectifier, two sets of IGBT switches, a diode and an inductor. In this scheme, the input mechanical energy of the wind turbine during grid fault is stored and utilized at the moment of fault clearance, instead of being dissipated in the resistors of the crowbar circuit as in the existing FRT schemes. Consequently, torque balance between the electrical and mechanical quantities is achieved and hence the rotor speed deviation and electromagnetic torque fluctuations are reduced. This results in reduced reactive power requirement and rapid reestablishment of terminal voltage on fault clearance. Furthermore, the stored electromagnetic energy in the inductor is transferred into the dc link capacitor on fault clearance and hence the grid side converter is relieved from charging the dc link capacitor, which is very crucial at this moment, and this converter can be utilized to its full capacity for rapid restoration of terminal voltage and normal operation of DFIG. Extensive simulation study carried out employing PSCAD/EMTDC software vividly demonstrates the potential capabilities of the proposed scheme in

  12. Fault Ride Through Capability Enhancement of a Large-Scale PMSG Wind System with Bridge Type Fault Current Limiters

    Directory of Open Access Journals (Sweden)

    ALAM, M. S.

    2018-02-01

    Full Text Available In this paper, bridge type fault current limiter (BFCL is proposed as a potential solution to the fault problems of permanent magnet synchronous generator (PMSG based large-scale wind energy system. As PMSG wind system is more vulnerable to disturbances, it is essential to guarantee the stability during severe disturbances by enhancing the fault ride through capability. BFCL controller has been designed to insert resistance and inductance during the inception of system disturbances in order to limit fault current. Constant capacitor voltage has been maintained by the grid voltage source converter (GVSC controller while current extraction or injection has been achieved by machine VSC (MVSC controller. Symmetrical and unsymmetrical faults have been applied in the system to show the effectiveness of the proposed BFCL solution. PMSG wind system, BFCL and their controllers have been implemented by real time hardware in loop (RTHIL setup with real time digital simulator (RTDS and dSPACE. Another significant feature of this work is that the performance of the proposed BFCL is compared with that of series dynamic braking resistor (SDBR. Comparative RTHIL implementation results show that the proposed BFCL is very efficient in improving system fault ride through capability by limiting the fault current and outperforms SDBR.

  13. Linac-augmented light sources : an incremental concept for enhancing the capabilities of existing 3rd-generation storage rings

    International Nuclear Information System (INIS)

    Lewellen, J. W.

    2003-01-01

    Planned and proposed 4th-generation x-ray sources, such as energy-recovery linacs (ERLs) and single-pass x-ray free-electron lasers (X-FELs) offer a number of potential advantages, including small source size, higher peak brightness, ultrashort pulses, and potentially temporally and transversely coherent pulses. While offering unique capabilities, such facilities will also offer several important limitations, including limited numbers of user beamlines (for FELs) and a pulse-repetition rate that may be too high for many dynamics experiments (ERLs). In addition, there are many technical challenges associated with both types of facilities. A third type of facility, exemplified by the Short Pulse Photon Source (SPPS) at SLAC [1], would support neither a large number of users simultaneously nor generate coherent pulses, but would generate very intense, short x-ray pulses. Such a facility could serve as the starting point for either an ERL or an X-FEL, or a combined, hybrid machine. For the foreseeable future, however, existing 3rd-generation light source storage rings, such as the Advanced Photon Source, will continue to play important roles in supporting scientific research utilizing high-brightness x-rays. Existing facilities offer the powerful combination of a large number of user beamlines, efficient use of electron beam energy, and established user communities, and a program of incremental investment in, and improvements to, these facilities should continue to pay dividends into the future. This document discusses potential upgrade paths based on the Advanced Photon Source (APS) as a model 3rd-generation facility. If existing 3rd-generation facilities are to remain centers of excellence for light source-based research into the future, they must not only maintain and enhance their support of their existing user base, but also seek to expand their capabilities to support additional classes of users. There are several paths available toward this goal. The APS is

  14. An interdisciplinary approach to identify adaptation strategies that enhance flood resilience and urban liveability

    DEFF Research Database (Denmark)

    Rogers, B. C.; Bertram, N.; Gunn, Alex

    This paper provides guidance on how to identify and design the most suitable climate adaptation strategies for enhancing the liveability and flood resilience of urban catchments. It presents findings from a case study of Elwood, a coastal Melbourne suburb regularly affected by flooding. The resea...

  15. Facile template-directed synthesis of carbon-coated SnO2 nanotubes with enhanced Li-storage capabilities

    International Nuclear Information System (INIS)

    Zhu, Xiaoshu; Zhu, Jingyi; Yao, Yinan; Zhou, Yiming; Tang, Yawen; Wu, Ping

    2015-01-01

    Herein, a novel type of carbon-coated SnO 2 nanotubes has been designed and synthesized through a facile two-step hydrothermal approach by using ZnO nanorods as templates. During the synthetic route, SnO 2 nanocrystals and carbon layer have been uniformly deposited on the rod-like templates in sequence, meanwhile ZnO nanorods could be in situ dissolved owing to the generated alkaline and acidic environments during hydrothermal coating of SnO 2 nanocrystals and hydrothermal carbonization of glucose, respectively. When utilized as an anode material in lithium-ion batteries, the carbon-coated SnO 2 nanotubes manifests markedly enhanced Li-storage capabilities in terms of specific capacity and cycling stability in comparison with bare SnO 2 nanocrystals. - Graphical abstract: Display Omitted - Highlights: • C-coated SnO 2 nanotubes prepared via facile ZnO-nanorod-templated hydrothermal route. • Unique morphological and structural features toward lithium storage. • Enhanced Li-storage performance in terms of specific capacity and cycling stability

  16. Elliptical Leaf Spring Shock and Vibration Mounts with Enhanced Damping and Energy Dissipation Capabilities Using Lead Spring

    Directory of Open Access Journals (Sweden)

    Moussa Leblouba

    2015-01-01

    Full Text Available We present an enhancement to the existing elliptical leaf spring (ELS for improved damping and energy dissipation capabilities. The ELS consists of a high tensile stainless steel elliptical leaf spring with polymer or rubber compound. This device is conceived as a shock and vibration isolator for equipment and lightweight structures. The enhancement to the ELS consists of a lead spring plugged vertically between the leaves (referred to as lead-rubber elliptical leaf spring (LRELS. The lead is shown to produce hysteretic damping under plastic deformations. The LRELS isolator is shown to exhibit nonlinear hysteretic behavior. In both horizontal directions, the LRELS showed symmetrical rate independent behavior but undergoes stiffening behavior under large displacements. However, in the vertical direction, the LRELS behavior is asymmetric, exhibiting softening behavior in compression and stiffening behavior in tension. Mathematical models based on the Bouc-Wen model, describing the hysteretic behavior of the proposed isolator, are developed and numerically calibrated using a series of finite element analyses. The LRELS is found to be effective in the in-plane and vertical directions. The improved damping and energy dissipation of the LRELS is provided from the hysteretic damping of the lead spring.

  17. Gender-differences in risk factors for suicidal behaviour identified by perceived burdensomeness, thwarted belongingness and acquired capability: cross-sectional analysis from a longitudinal cohort study.

    Science.gov (United States)

    Donker, Tara; Batterham, Philip J; Van Orden, Kimberly A; Christensen, Helen

    2014-01-01

    The Interpersonal-Psychological Theory of Suicidal Behavior (IPT) is supported by recent epidemiological data. Unique risk factors for the IPT constructs have been identified in community epidemiological studies. Gender differences in these risk factors may contribute substantially to our understanding of suicidal risk, and require further investigation. The present study explores gender differences in the predictors and correlates of perceived burdensomeness, thwarted belongingness and acquired capability for suicide. Participants (547 males, 739 females) aged 32-38 from the PATH through Life study, an Australian population-based longitudinal cohort study (n=1,177) were assessed on perceived burdensomeness, thwarted belongingness and acquired capability for suicide using the Interpersonal Needs Questionnaire and Acquired Capability for Suicide Survey, and on a range of demographic, social support, psychological, mental health and physical health measures. Gender differences in the predictors of the IPT constructs were assessed using linear regression analyses. Higher perceived burdensomeness increased suicide ideation in both genders, while higher thwarted belongingness increased suicide ideation only in females. In females, thwarted belongingness was uniquely related to perceived burdensomeness, while greater physical health was significantly associated with greater thwarted belongingness in males but not in females. There were trends suggesting greater effects of being single and greater perceived burdensomeness for men, and stronger effects of less positive friendship support for women associated with greater thwarted belongingness. Men and women differ in the pattern of psychological characteristics that predict suicide ideation, and in the factors predicting vulnerability. Suicide prevention strategies need to take account of gender differences.

  18. Enhanced Cognitive Walkthrough: Development of the Cognitive Walkthrough Method to Better Predict, Identify, and Present Usability Problems

    Directory of Open Access Journals (Sweden)

    Lars-Ola Bligård

    2013-01-01

    Full Text Available To avoid use errors when handling medical equipment, it is important to develop products with a high degree of usability. This can be achieved by performing usability evaluations in the product development process to detect and mitigate potential usability problems. A commonly used method is cognitive walkthrough (CW, but this method shows three weaknesses: poor high-level perspective, insufficient categorisation of detected usability problems, and difficulties in overviewing the analytical results. This paper presents a further development of CW with the aim of overcoming its weaknesses. The new method is called enhanced cognitive walkthrough (ECW. ECW is a proactive analytical method for analysis of potential usability problems. The ECW method has been employed to evaluate user interface designs of medical equipment such as home-care ventilators, infusion pumps, dialysis machines, and insulin pumps. The method has proved capable of identifying several potential use problems in designs.

  19. Training Enhances Immune Cells Mitochondrial Biosynthesis, Fission, Fusion, and Their Antioxidant Capabilities Synergistically with Dietary Docosahexaenoic Supplementation

    Directory of Open Access Journals (Sweden)

    Carla Busquets-Cortés

    2016-01-01

    Full Text Available Exercise training induces adaptations in mitochondrial metabolism, dynamics, and oxidative protection. Omega-3 fatty acids change membrane lipid composition and modulate mitochondrial function. The aim was to investigate the effect of 8-week training and docosahexaenoic acid (DHA supplementation (1.14 g/day on the mitochondria dynamics and antioxidant status in peripheral blood mononuclear cells (PBMCs from sportsmen. Subjects were assigned to an intervention (N=9 or placebo groups (N=7 in a randomized double-blind trial. Nutritional intervention significantly increased the DHA content in erythrocyte membranes from the experimental group. No significant differences were reported in terms of circulating PBMCs, Mn-superoxide dismutase protein levels, and their capability to produce reactive oxygen species. The proteins related to mitochondrial dynamics were, in general, increased after an 8-week training and this increase was enhanced by DHA supplementation. The content in mitofusins Mtf-1 and Mtf-2, optic atrophy protein-1 (Opa-1, and mitochondrial transcription factor A (Tfam were significantly higher in the DHA-supplemented group after intervention. Cytochrome c oxidase (COX-IV activity and uncoupling proteins UCP-2 and UCP-3 protein levels were increased after training, with higher UCP-3 levels in the supplemented group. In conclusion, training induced mitochondrial adaptations which may contribute to improved mitochondrial function. This mitochondrial response was modulated by DHA supplementation.

  20. Polymer-derived-SiCN ceramic/graphite composite as anode material with enhanced rate capability for lithium ion batteries

    Science.gov (United States)

    Graczyk-Zajac, M.; Fasel, C.; Riedel, R.

    2011-08-01

    We report on a new composite material in view of its application as a negative electrode in lithium-ion batteries. A commercial preceramic polysilazane mixed with graphite in 1:1 weight ratio was transformed into a SiCN/graphite composite material through a pyrolytic polymer-to-ceramic conversion at three different temperatures, namely 950 °C, 1100 °C and 1300 °C. By means of Raman spectroscopy we found successive ordering of carbon clusters into nano-crystalline graphitic regions with increasing pyrolysis temperature. The reversible capacity of about 350 mAh g-1 was measured with constant current charging/discharging for the composite prepared at 1300 °C. For comparison pure graphite and pure polysilazane-derived SiCN ceramic were examined as reference materials. During fast charging and discharging the composite material demonstrates enhanced capacity and stability. Charging and discharging in half an hour lead to about 200 and 10 mAh g-1, for the composite annealed at 1300 °C and pure graphite, respectively. A clear dependence between the final material capacity and pyrolysis temperature is found and discussed with respect to possible application in batteries, i.e. practical discharging potential limit. The best results in terms of capacity recovered under 1 V and high rate capability were also obtained for samples synthesized at 1300 °C.

  1. Participation in EU SARNET2 Project for an Enhancement of Severe Accident Evaluation Capability in Domestic NPPs

    International Nuclear Information System (INIS)

    Ahn, Kwang Il; Hong, S. W.; Kim, S. B.; Park, J. H.; Song, Y. M.

    2010-07-01

    The following results were obtained from the first year SARNET2 research activities. - WP4-2 session : acquisition of ASTEC 2.0 execution version, user manual and modeling/technical report for main six modules, code familiarization via ASTEC 2.0 code structure analysis and sample calculations. - WP6-4 session : preliminary calculations for APR1400 MCCI using MELCOR code. - WP7-1 session : thermal-hydraulic review of particle solidification model for steam explosion, suggestion of further activities for modeling corium material effect, review of physio-chemical particles and its applicability for modeling corium material effect. - WP7-2 session: review and benchmark analysis of ENACCEF experiments by participating in Task 3 'Combustion benchmark', and submission of analysis results for blind tests and preparation of analysis for open tests. - WP8-3 session: acquisition of ISTP Database and recent reports for two experiments (EPICUR/PARIS), review of technical issues in ST/FP, and selection of its domestic application field. The foregoing research results and experimental database for main SA issues obtained by this research are expected to be used for resolving SA issue remained in domestic NPPs (operating, to be constructed, future) and enhancing the evaluating capability of Level-2 PSA

  2. Enhancing electrical energy storage capability of dielectric polymer nanocomposites via the room temperature Coulomb blockade effect of ultra-small platinum nanoparticles.

    Science.gov (United States)

    Wang, Liwei; Huang, Xingyi; Zhu, Yingke; Jiang, Pingkai

    2018-02-14

    Introducing a high dielectric constant (high-k) nanofiller into a dielectric polymer is the most common way to achieve flexible nanocomposites for electrostatic energy storage devices. However, the significant decrease of breakdown strength and large increase of dielectric loss has long been known as the bottleneck restricting the enhancement of practical energy storage capability of the nanocomposites. In this study, by introducing ultra-small platinum (energy density of the Pt@PDA@BT nanocomposites is increased by nearly 70% because of the improved energy storage efficiency. This research provides a simple, promising and unique way to enhance energy storage capability of high-k polymer nanocomposites.

  3. Enhancing the Employability of Chinese International Students: Identifying Achievements and Gaps in the Research Field

    Directory of Open Access Journals (Sweden)

    Xuemeng Cao

    2017-10-01

    Full Text Available This article shows what achievements have been made by existing studies on graduate employability, and what gaps need to be filled in this field. It starts with a retrospective account of the changing concept of employability, followed by a presentation of the practices that have been used to support graduate employability enhancement in different countries. Moreover, this article gives a critical review of Chinese contexts of graduate labour market. Last but not least, limitations of existing studies are identified, which reflect an expectation for future research on graduate employability to meet the demand of an increasingly international dimension of higher education.

  4. Development of Human Breast Milk Microbiota-Associated Mice as a Method to Identify Breast Milk Bacteria Capable of Colonizing Gut.

    Science.gov (United States)

    Wang, Xiaoxin; Lu, Huifang; Feng, Zhou; Cao, Jie; Fang, Chao; Xu, Xianming; Zhao, Liping; Shen, Jian

    2017-01-01

    Human breast milk is recognized as one of multiple important sources of commensal bacteria for infant gut. Previous studies searched for the bacterial strains shared between breast milk and infant feces by isolating bacteria and performing strain-level bacterial genotyping, but only limited number of milk bacteria were identified to colonize infant gut, including bacteria from Bifidobacterium , Staphylococcus , Lactobacillus , and Escherichia / Shigella . Here, to identify the breast milk bacteria capable of colonizing gut without the interference of bacteria of origins other than the milk or the necessity to analyze infant feces, normal chow-fed germ-free mice were orally inoculated with the breast milk collected from a mother 2 days after vaginal delivery. According to 16S rRNA gene-based denaturant gradient gel electrophoresis and Illumina sequencing, bacteria at >1% abundance in the milk inoculum were only Streptococcus (56.0%) and Staphylococcus (37.4%), but in the feces of recipient mice were Streptococcus (80.3 ± 2.3%), Corynebacterium (10.0 ± 2.6 %), Staphylococcus (7.6 ± 1.6%), and Propionibacterium (2.1 ± 0.5%) that were previously shown as dominant bacterial genera in the meconium of C-section-delivered human babies; the abundance of anaerobic gut-associated bacteria, Faecalibacterium , Prevotella , Roseburia , Ruminococcus , and Bacteroides , was 0.01-1% in the milk inoculum and 0.003-0.01% in mouse feces; the abundance of Bifidobacterium spp. was below the detection limit of Illumina sequencing in the milk but at 0.003-0.01% in mouse feces. The human breast milk microbiota-associated mouse model may be used to identify additional breast milk bacteria that potentially colonize infant gut.

  5. Bat Accelerated Regions Identify a Bat Forelimb Specific Enhancer in the HoxD Locus.

    Directory of Open Access Journals (Sweden)

    Betty M Booker

    2016-03-01

    Full Text Available The molecular events leading to the development of the bat wing remain largely unknown, and are thought to be caused, in part, by changes in gene expression during limb development. These expression changes could be instigated by variations in gene regulatory enhancers. Here, we used a comparative genomics approach to identify regions that evolved rapidly in the bat ancestor, but are highly conserved in other vertebrates. We discovered 166 bat accelerated regions (BARs that overlap H3K27ac and p300 ChIP-seq peaks in developing mouse limbs. Using a mouse enhancer assay, we show that five Myotis lucifugus BARs drive gene expression in the developing mouse limb, with the majority showing differential enhancer activity compared to the mouse orthologous BAR sequences. These include BAR116, which is located telomeric to the HoxD cluster and had robust forelimb expression for the M. lucifugus sequence and no activity for the mouse sequence at embryonic day 12.5. Developing limb expression analysis of Hoxd10-Hoxd13 in Miniopterus natalensis bats showed a high-forelimb weak-hindlimb expression for Hoxd10-Hoxd11, similar to the expression trend observed for M. lucifugus BAR116 in mice, suggesting that it could be involved in the regulation of the bat HoxD complex. Combined, our results highlight novel regulatory regions that could be instrumental for the morphological differences leading to the development of the bat wing.

  6. Incorporating Geodectic Processing Modules into a Real-Time Earthworm Environment to Enhance NOAA's Tsunami Warning Capability

    Science.gov (United States)

    Macpherson, K. A.

    2017-12-01

    The National Oceanographic and Atmospheric Administration's National and Pacific Tsunami Warning Centers currently rely on traditional seismic data in order to detect and evaluate potential tsunamigenic earthquakes anywhere on the globe. The first information products disseminated by the centers following a significant seismic event are based solely on seismically-derived earthquake locations and magnitudes, and are issued within minutes of the earthquake origin time. Thus, the rapid and reliable determination of the earthquake magnitude is a critical piece of information needed by the centers to generate the appropriate alert levels. However, seismically-derived magnitudes of large events are plagued by well-known problems, particularly during the first few minutes following the origin time; near-source broad-band instruments may go off scale, and magnitudes tend to saturate until sufficient teleseismic data arrive to represent the long-period signal that characterizes large events. However, geodetic data such as high-rate Global Positioning System (hGPS) displacements and seismogeodetic data that is a combination of collocated hGPS and accelerometer data do not suffer from these limitations. These sensors stay on scale, even for large events, and they record both dynamic and static displacements that may be used to estimate magnitude without saturation. Therefore, there is an ongoing effort to incorporate these data streams into the operations of the tsunami warning centers to enhance current magnitude determination capabilities, and eventually, to invert the geodetic displacements for mechanism and finite-fault information. These later quantities will be useful for tsunami modeling and forecasting. The tsunami warning centers rely on the Earthworm system for real-time data acquisition, so we have developed Earthworm modules for the Magnitude from Peak Ground Displacement (MPGD) algorithm, developed at the University of Washington and the University of California

  7. Dynamic Contrast-Enhanced MRI of Cervical Cancers: Temporal Percentile Screening of Contrast Enhancement Identifies Parameters for Prediction of Chemoradioresistance

    International Nuclear Information System (INIS)

    Andersen, Erlend K.F.; Hole, Knut Håkon; Lund, Kjersti V.; Sundfør, Kolbein; Kristensen, Gunnar B.; Lyng, Heidi; Malinen, Eirik

    2012-01-01

    Purpose: To systematically screen the tumor contrast enhancement of locally advanced cervical cancers to assess the prognostic value of two descriptive parameters derived from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Methods and Materials: This study included a prospectively collected cohort of 81 patients who underwent DCE-MRI with gadopentetate dimeglumine before chemoradiotherapy. The following descriptive DCE-MRI parameters were extracted voxel by voxel and presented as histograms for each time point in the dynamic series: normalized relative signal increase (nRSI) and normalized area under the curve (nAUC). The first to 100th percentiles of the histograms were included in a log-rank survival test, resulting in p value and relative risk maps of all percentile–time intervals for each DCE-MRI parameter. The maps were used to evaluate the robustness of the individual percentile–time pairs and to construct prognostic parameters. Clinical endpoints were locoregional control and progression-free survival. The study was approved by the institutional ethics committee. Results: The p value maps of nRSI and nAUC showed a large continuous region of percentile–time pairs that were significantly associated with locoregional control (p < 0.05). These parameters had prognostic impact independent of tumor stage, volume, and lymph node status on multivariate analysis. Only a small percentile–time interval of nRSI was associated with progression-free survival. Conclusions: The percentile–time screening identified DCE-MRI parameters that predict long-term locoregional control after chemoradiotherapy of cervical cancer.

  8. Enhanced surveillance of Staphylococcus aureus bacteraemia to identify targets for infection prevention.

    Science.gov (United States)

    Morris, A K; Russell, C D

    2016-06-01

    Surveillance of Staphylococcus aureus bacteraemia (SAB) in Scotland is limited to the number of infections per 100,000 acute occupied bed-days and susceptibility to meticillin. To demonstrate the value of enhanced SAB surveillance to identify targets for infection prevention. Prospective cohort study of all patients identified with SAB over a five-year period in a single health board in Scotland. All patients were reviewed at the bedside by a clinical microbiologist. In all, 556 SAB episodes were identified: 261 (46.6%) were hospital-acquired; 209 (37.9%) were healthcare-associated; 80 (14.4%) were community-acquired; and in six (1.1%) the origin of infection was not hospital-acquired, but could not be separated into healthcare-associated or community-acquired. These were classified as non-hospital-acquired. Meticillin-resistant S. aureus (MRSA) bacteraemia was associated with hospital-acquired and healthcare-associated infections. In addition, there was a significantly higher 30-day mortality associated with hospital-acquired (31.4%) and healthcare-associated (16.3%) infections compared to community-acquired SAB (8.7%). Vascular access devices were associated with hospital-acquired SAB and peripheral venous cannulas were the source for most of these (43.9%). Community-acquired infections were associated with intravenous drug misuse, respiratory tract infections and skeletal and joint infections. Skin and soft tissue infections were more widely seen in healthcare-associated infections. The data indicate that enhanced surveillance of SAB by origin of infection and source of bacteraemia has implications for infection prevention, empirical antibiotic therapy, and health improvement interventions. Copyright © 2016 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

  9. Realigning Coast Guard Enhanced Maritime Capabilities: A Lesson Learned from the U.S. Special Operations Command

    National Research Council Canada - National Science Library

    Poulin, Steven D

    2005-01-01

    .... The Coast Guard faces major challenges in executing its responsibilities and must leverage the capabilities of its specially trained boarding teams, small boat security forces, and hazardous materials response teams...

  10. Enhancement of loss detection capability using a combination of the Kalman Filter/Linear Smoother and controllable unit accounting approach

    International Nuclear Information System (INIS)

    Pike, D.H.; Morrison, G.W.

    1979-01-01

    An approach to loss detection is presented which combines the optimal loss detection capability of state estimation techniques with a controllable unit accounting approach. The state estimation theory makes use of a linear system model which is capable of modeling the interaction of various controllable unit areas within a given facility. An example is presented which illustrates the increase in loss detection probability which is realizable with state estimation techniques. Comparisons are made with a Shewhart Control Chart and the CUSUM statistic

  11. Metabolomic approach to identifying bioactive compounds in berries: advances toward fruit nutritional enhancement.

    Science.gov (United States)

    Stewart, Derek; McDougall, Gordon J; Sungurtas, Julie; Verrall, Susan; Graham, Julie; Martinussen, Inger

    2007-06-01

    Plant polyphenolics continue to be the focus of attention with regard to their putative impact on human health. An increasing and ageing human population means that the focus on nutrition and nutritional enhancement or optimisation of our foodstuffs is paramount. Using the raspberry as a model, we have shown how modern metabolic profiling approaches can be used to identify the changes in the level of beneficial polyphenolics in fruit breeding segregating populations and how the level of these components is determined by genetic and/or environmental control. Interestingly, the vitamin C content appeared to be significantly influenced by environment (growth conditions) whilst the content of the polyphenols such as cyanidin, pelargonidin and quercetin glycosides appeared much more tightly regulated, suggesting a rigorous genetic control. Preliminary metabolic profiling showed that the fruit polyphenolic profiles divided into two gross groups segregating on the basis of relative levels of cyanidin-3-sophoroside and cyanidin-3-rutinoside, compounds implicated as conferring human health benefits.

  12. RNA interference screen to identify pathways that enhance or reduce nonviral gene transfer during lipofection.

    Science.gov (United States)

    Barker, Gregory A; Diamond, Scott L

    2008-09-01

    Some barriers to DNA lipofection are well characterized; however, there is as yet no method of finding unknown pathways that impact the process. A druggable genome small-interfering RNA (siRNA) screen against 5,520 genes was tested for its effect on lipofection of human aortic endothelial cells (HAECs). We found 130 gene targets which, when silenced by pooled siRNAs (three siRNAs per gene), resulted in enhanced luminescence after lipofection (86 gene targets showed reduced expression). In confirmation tests with single siRNAs, 18 of the 130 hits showed enhanced lipofection with two or more individual siRNAs in the absence of cytotoxicity. Of these confirmed gene targets, we identified five leading candidates, two of which are isoforms of the regulatory subunit of protein phosphatase 2A (PP2A). The best candidate siRNA targeted the PPP2R2C gene and produced a 65% increase in luminescence from lipofection, with a quantitative PCR-validated knockdown of approximately 76%. Flow cytometric analysis confirmed that the silencing of the PPP2R2C gene resulted in an improvement of 10% in transfection efficiency, thereby demonstrating an increase in the number of transfected cells. These results show that an RNA interference (RNAi) high-throughput screen (HTS) can be applied to nonviral gene transfer. We have also demonstrated that siRNAs can be co-delivered with lipofected DNA to increase the transfection efficiency in vitro.

  13. Capability Paternalism

    NARCIS (Netherlands)

    Claassen, R.J.G.|info:eu-repo/dai/nl/269266224

    A capability approach prescribes paternalist government actions to the extent that it requires the promotion of specific functionings, instead of the corresponding capabilities. Capability theorists have argued that their theories do not have much of these paternalist implications, since promoting

  14. Single-cell analyses identify bioengineered niches for enhanced maintenance of hematopoietic stem cells.

    Science.gov (United States)

    Roch, Aline; Giger, Sonja; Girotra, Mukul; Campos, Vasco; Vannini, Nicola; Naveiras, Olaia; Gobaa, Samy; Lutolf, Matthias P

    2017-08-09

    The in vitro expansion of long-term hematopoietic stem cells (HSCs) remains a substantial challenge, largely because of our limited understanding of the mechanisms that control HSC fate choices. Using single-cell multigene expression analysis and time-lapse microscopy, here we define gene expression signatures and cell cycle hallmarks of murine HSCs and the earliest multipotent progenitors (MPPs), and analyze systematically single HSC fate choices in culture. Our analysis revealed twelve differentially expressed genes marking the quiescent HSC state, including four genes encoding cell-cell interaction signals in the niche. Under basal culture conditions, most HSCs rapidly commit to become early MPPs. In contrast, when we present ligands of the identified niche components such as JamC or Esam within artificial niches, HSC cycling is reduced and long-term multipotency in vivo is maintained. Our approach to bioengineer artificial niches should be useful in other stem cell systems.Haematopoietic stem cell (HSC) self-renewal is not sufficiently understood to recapitulate in vitro. Here, the authors generate gene signature and cell cycle hallmarks of single murine HSCs, and use identified endothelial receptors Esam and JamC as substrates to enhance HSC growth in engineered niches.

  15. ADAPTIVE MONITORING TO ENHANCE WATER SENSOR CAPABILITIES FOR CHEMICAL AND BIOLOGICAL CONTAMINANT DETECTION IN DRINKING WATER SYSTEMS

    Science.gov (United States)

    Optoelectronic and other conventional water quality sensors offer a potential for real-time online detection of chemical and biological contaminants in a drinking water supply and distribution system. The nature of the application requires sensors of detection capabilities at lo...

  16. An Enhanced Capability to Model How Compensation Policy Affects U.S. Department of Defense Civil Service Retention and Cost

    Science.gov (United States)

    2016-01-01

    bill for the force, con- sistently with OPM’s actuarial practice. This gives an amount—an accrual charge—sufficient to cover the retirement...capability could also be extended to other occupational areas within DoD, including the cyber workforce; to other pay systems, such as the science

  17. Solution scanning as a key policy tool: identifying management interventions to help maintain and enhance regulating ecosystem services

    Directory of Open Access Journals (Sweden)

    William J. Sutherland

    2014-06-01

    Full Text Available The major task of policy makers and practitioners when confronted with a resource management problem is to decide on the potential solution(s to adopt from a range of available options. However, this process is unlikely to be successful and cost effective without access to an independently verified and comprehensive available list of options. There is currently burgeoning interest in ecosystem services and quantitative assessments of their importance and value. Recognition of the value of ecosystem services to human well-being represents an increasingly important argument for protecting and restoring the natural environment, alongside the moral and ethical justifications for conservation. As well as understanding the benefits of ecosystem services, it is also important to synthesize the practical interventions that are capable of maintaining and/or enhancing these services. Apart from pest regulation, pollination, and global climate regulation, this type of exercise has attracted relatively little attention. Through a systematic consultation exercise, we identify a candidate list of 296 possible interventions across the main regulating services of air quality regulation, climate regulation, water flow regulation, erosion regulation, water purification and waste treatment, disease regulation, pest regulation, pollination and natural hazard regulation. The range of interventions differs greatly between habitats and services depending upon the ease of manipulation and the level of research intensity. Some interventions have the potential to deliver benefits across a range of regulating services, especially those that reduce soil loss and maintain forest cover. Synthesis and applications: Solution scanning is important for questioning existing knowledge and identifying the range of options available to researchers and practitioners, as well as serving as the necessary basis for assessing cost effectiveness and guiding implementation strategies. We

  18. Transformer-based asymmetrical embedded Z-source neutral point clamped inverters with continuous input current and enhanced voltage boost capability

    DEFF Research Database (Denmark)

    Mo, W.; Loh, Poh Chiang; Blaabjerg, Frede

    2013-01-01

    Z-source Neutral Point Clamped (NPC) inverters were introduced to integrate both the advantages of Z-source inverters and NPC inverters. However, traditional Z-source inverters suffer from high voltage stress and chopping input current. This paper proposes six types transformer-based impedance-so......-source NPC inverters which have enhanced voltage boost capability and continuous input current by utilizing of transformer and embedded dc source configuration. Experimental results are presented to verify the theory validation....

  19. The Future Today: Creating an All Purpose Battalion to Enhance the Marine Corps’ Capabilities for Tomorrow, Today

    Science.gov (United States)

    2008-01-01

    Maude, (Houghton Mifflin, Boston MA, and New York, NY, 1920), p. 279. 21Author’s notes from personal interview. . 22Philip Kotler , Marketing Management...adhere to the principle of unity of command and provide the Marine Corps with a credible and confident force in readiness, capable of supporting all...one command. This simple creation of a new unit, essentially a headquarters element, will adhere to the principle of unity of command and provide the

  20. Phenotypic Screening Identifies Synergistically Acting Natural Product Enhancing the Performance of Biomaterial Based Wound Healing

    Directory of Open Access Journals (Sweden)

    Srinivasan Sivasubramanian

    2017-07-01

    Full Text Available The potential of multifunctional wound heal biomaterial relies on the optimal content of therapeutic constituents as well as the desirable physical, chemical, and biological properties to accelerate the healing process. Formulating biomaterials such as amnion or collagen based scaffolds with natural products offer an affordable strategy to develop dressing material with high efficiency in healing wounds. Using image based phenotyping and quantification, we screened natural product derived bioactive compounds for modulators of types I and III collagen production from human foreskin derived fibroblast cells. The identified hit was then formulated with amnion to develop a biomaterial, and its biophysical properties, in vitro and in vivo effects were characterized. In addition, we performed functional profiling analyses by PCR array to understand the effect of individual components of these materials on various genes such as inflammatory mediators including chemokines and cytokines, growth factors, fibroblast stimulating markers for collagen secretion, matrix metalloproteinases, etc., associated with wound healing. FACS based cell cycle analyses were carried out to evaluate the potential of biomaterials for induction of proliferation of fibroblasts. Western blot analyses was done to examine the effect of biomaterial on collagen synthesis by cells and compared to cells grown in the presence of growth factors. This work demonstrated an uncomplicated way of identifying components that synergistically promote healing. Besides, we demonstrated that modulating local wound environment using biomaterials with bioactive compounds could enhance healing. This study finds that the developed biomaterials offer immense scope for healing wounds by means of their skin regenerative features such as anti-inflammatory, fibroblast stimulation for collagen secretion as well as inhibition of enzymes and markers impeding the healing, hydrodynamic properties complemented

  1. Enhancing regulatory effectiveness by improving the process for identifying and resolving generic issues

    International Nuclear Information System (INIS)

    Vander Molen, Harold J.

    2001-01-01

    The Generic Issues Program first began formally in response to a Commission directive in October of 1976. In 1983, it became one of the first programs to make successful use of probabilistic risk information to aid in regulatory decision-making. In the 16 years since the program became quantitative, 836 issues have been processed. Of these, 106 reactor safety issues were prioritized as requiring further evaluation to determine the final resolution. Approximately a dozen generic issues remain unresolved. Although there is far less reactor licensing activity than in the 1970s, new issues continue to be identified from research and operational experience. These issues often involve complex and controversial questions of safety and regulation, and an efficient and effective means of addressing these issues is essential for regulatory effectiveness. Issues that involve a significant safety question require swift, effective, enforceable, and cost-effective regulatory actions. Issues that are of little safety significance must be quickly shown to be so and dismissed in an expeditious manner so as to avoid unnecessary expenditure of limited resources and to reduce regulatory uncertainty. Additionally, in the time since the generic issue program began, probabilistic risk assessment techniques have advanced significantly while agency resources have continued to diminish. Accordingly, the paper discusses the steps that have been taken to enhance the effectiveness and efficiency of the generic issue resolution process. Additionally, four resolved issues are discussed, along with key elements of a proposed new procedure for resolving potential generic issues

  2. Substantial enhancement of energy storage capability in polymer nanocomposites by encapsulation of BaTiO3 NWs with variable shell thickness.

    Science.gov (United States)

    Wang, Guanyao; Huang, Yanhui; Wang, Yuxin; Jiang, Pingkai; Huang, Xingyi

    2017-08-09

    Dielectric polymer nanocomposites have received keen interest due to their potential application in energy storage. Nevertheless, the large contrast in dielectric constant between the polymer and nanofillers usually results in a significant decrease of breakdown strength of the nanocomposites, which is unfavorable for enhancing energy storage capability. Herein, BaTiO 3 nanowires (NWs) encapsulated by TiO 2 shells of variable thickness were utilized to fabricate dielectric polymer nanocomposites. Compared with nanocomposites with bare BaTiO 3 NWs, significantly enhanced energy storage capability was achieved for nanocomposites with TiO 2 encapsulated BaTiO 3 NWs. For instance, an ultrahigh energy density of 9.53 J cm -3 at 440 MV m -1 could be obtained for nanocomposites comprising core-shell structured nanowires, much higher than that of nanocomposites with 5 wt% raw ones (5.60 J cm -3 at 360 MV m -1 ). The discharged energy density of the proposed nanocomposites with 5 wt% mTiO 2 @BaTiO 3 -1 NWs at 440 MV m -1 seems to rival or exceed those of some previously reported nanocomposites (mostly comprising core-shell structured nanofillers). More notably, this study revealed that the energy storage capability of the nanocomposites can be tailored by the TiO 2 shell thickness. Finite element simulations were employed to analyze the electric field distribution in the nanocomposites. The enhanced energy storage capability should be mainly attributed to the smoother gradient of dielectric constant between the nanofillers and polymer matrix, which alleviated the electric field concentration and leakage current in the polymer matrix. The methods and results herein offer a feasible approach to construct high-energy-density polymer nanocomposites with core-shell structured nanowires.

  3. Mussel-inspired Fluoro-Polydopamine Functionalization of Titanium Dioxide Nanowires for Polymer Nanocomposites with Significantly Enhanced Energy Storage Capability

    Science.gov (United States)

    Wang, Guanyao; Huang, Xingyi; Jiang, Pingkai

    2017-01-01

    High-dielectric-constant polymer nanocomposites are demonstrated to show great promise as energy storage materials. However, the large electrical mismatch and incompatibility between nanofillers and polymer matrix usually give rise to significantly reduced breakdown strength and weak energy storage capability. Therefore, rational selection and elaborate functionalization of nanofillers to optimize the performance of polymer nanocomposites are vital. Herein, inspired by adhesive proteins in mussels, a facile modification by fluoro-polydopamine is employed to reinforce the compatibility of TiO2 nanowires in the fluoropolymer matrix. The loading of 2.5 vol % f-DOPA@TiO2 NWs leads to an ultrahigh discharged energy density of 11.48 J cm−3 at 530 MV m−1, more than three times of commercial biaxial-oriented polypropylene (BOPP, 3.56 J cm−3 at 600 MV m−1). A gratifying high energy density of 9.12 J cm−3 has also been obtained with nanofiller loading as high as 15 vol % at 360 MV m−1, which is nearly double to that of pure P(VDF-HFP) (4.76 J cm−3 at 360 MV m−1). This splendid energy storage capability seems to rival or exceed most of previously reported nano-TiO2 based nanocomposites. The methods presented here provide deep insights into the design of polymer nanocomposites for energy storage applications. PMID:28225047

  4. Mussel-inspired Fluoro-Polydopamine Functionalization of Titanium Dioxide Nanowires for Polymer Nanocomposites with Significantly Enhanced Energy Storage Capability

    Science.gov (United States)

    Wang, Guanyao; Huang, Xingyi; Jiang, Pingkai

    2017-02-01

    High-dielectric-constant polymer nanocomposites are demonstrated to show great promise as energy storage materials. However, the large electrical mismatch and incompatibility between nanofillers and polymer matrix usually give rise to significantly reduced breakdown strength and weak energy storage capability. Therefore, rational selection and elaborate functionalization of nanofillers to optimize the performance of polymer nanocomposites are vital. Herein, inspired by adhesive proteins in mussels, a facile modification by fluoro-polydopamine is employed to reinforce the compatibility of TiO2 nanowires in the fluoropolymer matrix. The loading of 2.5 vol % f-DOPA@TiO2 NWs leads to an ultrahigh discharged energy density of 11.48 J cm-3 at 530 MV m-1, more than three times of commercial biaxial-oriented polypropylene (BOPP, 3.56 J cm-3 at 600 MV m-1). A gratifying high energy density of 9.12 J cm-3 has also been obtained with nanofiller loading as high as 15 vol % at 360 MV m-1, which is nearly double to that of pure P(VDF-HFP) (4.76 J cm-3 at 360 MV m-1). This splendid energy storage capability seems to rival or exceed most of previously reported nano-TiO2 based nanocomposites. The methods presented here provide deep insights into the design of polymer nanocomposites for energy storage applications.

  5. An Active-Radio-Frequency-Identification system capable of identifying co-locations and social-structure: validation with a wild free-ranging animal

    OpenAIRE

    Ellwood, SA; Newman, C; Montgomery, RA; Nicosia, V; Buesching, CD; Markham, A; Mascolo, C; Trigoni, N; Pasztor, B; Dyo, V; Latora, V; Baker, SE; Macdonald, DW

    2017-01-01

    Behavioural events that are important for understanding sociobiology and movement ecology are often rare, transient and localised, but can occur at spatially distant sites e.g. territorial incursions and co-locating individuals. Existing animal tracking technologies, capable of detecting such events, are limited by one or more of: battery life; data resolution; location accuracy; data security; ability to co-locate individuals both spatially and temporally. Technology that at least partly res...

  6. Flexible free-standing porous graphene/Ni film electrode with enhanced rate capability for lithium-ion batteries

    International Nuclear Information System (INIS)

    Cao, Hailiang; Zhou, Xufeng; Shi, Junli; Liu, Zhaoping

    2016-01-01

    Flexible, lightweight and reliable lithium-ion batteries have attracted tremendous attention and research interest to meet the requirements of portable and bendable devices. Here, flexible, free-standing and porous graphene/Ni film with vertical nano-channels inside is prepared by metal etching of graphene film. Compared with dense graphene film, the porous graphene/Ni film employed as a binder-free anode in lithium-ion batteries exhibits higher capacity and much better rate capability, due to its unique interior channel architecture which is favorable for fast ion transport. At a high current density of 2 A g"−"1, it can reach a specific capacity of 117 mAh g"−"1. The porous film also shows low charge transfer resistance and good cycling stability. After 300 cycles at 1 A g"−"1, its specific capacity still remains at 147 mAh g"−"1, with high Coulombic efficiency of nearly 100%. Furthermore, the strategy developed here is very simple and of great importance to rational design of porous graphene film or graphene-based hybrids with various applications.

  7. Flexible free-standing porous graphene/Ni film electrode with enhanced rate capability for lithium-ion batteries

    Energy Technology Data Exchange (ETDEWEB)

    Cao, Hailiang; Zhou, Xufeng, E-mail: zhouxf@nimte.ac.cn; Shi, Junli; Liu, Zhaoping, E-mail: liuzp@nimte.ac.cn

    2016-11-15

    Flexible, lightweight and reliable lithium-ion batteries have attracted tremendous attention and research interest to meet the requirements of portable and bendable devices. Here, flexible, free-standing and porous graphene/Ni film with vertical nano-channels inside is prepared by metal etching of graphene film. Compared with dense graphene film, the porous graphene/Ni film employed as a binder-free anode in lithium-ion batteries exhibits higher capacity and much better rate capability, due to its unique interior channel architecture which is favorable for fast ion transport. At a high current density of 2 A g{sup −1}, it can reach a specific capacity of 117 mAh g{sup −1}. The porous film also shows low charge transfer resistance and good cycling stability. After 300 cycles at 1 A g{sup −1}, its specific capacity still remains at 147 mAh g{sup −1}, with high Coulombic efficiency of nearly 100%. Furthermore, the strategy developed here is very simple and of great importance to rational design of porous graphene film or graphene-based hybrids with various applications.

  8. Spin-valves with modified synthetic antiferromagnets exhibiting an enhanced bias point control capability at submicrometer dimensions

    International Nuclear Information System (INIS)

    Park, J.-S.; Lee, S.-R.; Kim, Y.K.

    2004-01-01

    Bias point control is of practical importance for operating read sensors for magnetic recording and magnetic random access memory devices. To attain bias point control capability, in particular, at submicrometer cell size, a modified synthetic antiferromagnet-based spin-valve (MSSV) structure was devised. A series of calculations were carried out to investigate the effect of size variation on their MR transfer behaviors. The cell dimension was varied from 10 to 0.05 μm. The typical MSSV comprises IrMn (9.0)/CoFe (P1, 1.5)/Ru (0.7)/CoFe (P2, 3.0)/Ru (0.7)/CoFe (P3, 1.5)/Cu (2.8)/CoFe (1.6)/NiFe (3.2) (in nm). As the cell size decreased, the bias point in the MSSV maintained nearly zero regardless of the cell size. The bias point was further tuned by varying the P3 layer thickness. Moreover, the effective exchange field (H ex.eff ) of the MSSV was much larger than that of the conventional SSV. The field sensitivity of the MSSV was very high indicating that the free layer can rotate more sharply

  9. Spin-valves with modified synthetic antiferromagnets exhibiting an enhanced bias point control capability at submicrometer dimensions

    Science.gov (United States)

    Park, Jeong-Suk; Lee, Seong-Rae; Kim, Young Keun

    2004-08-01

    Bias point control is of practical importance for operating read sensors for magnetic recording and magnetic random access memory devices. To attain bias point control capability, in particular, at submicrometer cell size, a modified synthetic antiferromagnet-based spin-valve (MSSV) structure was devised. A series of calculations were carried out to investigate the effect of size variation on their MR transfer behaviors. The cell dimension was varied from 10 to 0.05 μm. The typical MSSV comprises IrMn (9.0)/CoFe (P1, 1.5)/Ru (0.7)/CoFe (P2, 3.0)/Ru (0.7)/CoFe (P3, 1.5)/Cu (2.8)/CoFe (1.6)/NiFe (3.2) (in nm). As the cell size decreased, the bias point in the MSSV maintained nearly zero regardless of the cell size. The bias point was further tuned by varying the P3 layer thickness. Moreover, the effective exchange field ( Hex.eff) of the MSSV was much larger than that of the conventional SSV. The field sensitivity of the MSSV was very high indicating that the free layer can rotate more sharply.

  10. Second-order sliding mode control for DFIG-based wind turbines fault ride-through capability enhancement.

    Science.gov (United States)

    Benbouzid, Mohamed; Beltran, Brice; Amirat, Yassine; Yao, Gang; Han, Jingang; Mangel, Hervé

    2014-05-01

    This paper deals with the fault ride-through capability assessment of a doubly fed induction generator-based wind turbine using a high-order sliding mode control. Indeed, it has been recently suggested that sliding mode control is a solution of choice to the fault ride-through problem. In this context, this paper proposes a second-order sliding mode as an improved solution that handle the classical sliding mode chattering problem. Indeed, the main and attractive features of high-order sliding modes are robustness against external disturbances, the grids faults in particular, and chattering-free behavior (no extra mechanical stress on the wind turbine drive train). Simulations using the NREL FAST code on a 1.5-MW wind turbine are carried out to evaluate ride-through performance of the proposed high-order sliding mode control strategy in case of grid frequency variations and unbalanced voltage sags. Copyright © 2014 ISA. Published by Elsevier Ltd. All rights reserved.

  11. Enhancing load-following and/or spectral shift capability in single-sparger natural circulation boiling water reactors

    International Nuclear Information System (INIS)

    Oosterkamp, W.J.

    1992-01-01

    This patent describes a method for obtaining load-following capability in a coiling water reactor (BWR) wherein housed within a reactor pressure vessel (RPV) is a nuclear core disposed within a shroud having a shroud head and which with the RPV defines an annulus region disposed beneath the nuclear core, an upper steam dome connected to a steam outlet in the RPV, a core upper plenum formed within the shroud head and disposed atop the nuclear core, a chimney mounted atop the shroud head and in fluid communication with the core upper plenum and with a steam separator having a skirt which is in fluid communication with the steam dome, the region outside of the chimney defining a downcomer region, there being a water level established therein under normal operation of the BWR, and the RPV containing a feedwater inlet. It comprises: disposing a single sparger connected to the feedwater inlet above the steam separator skirt bottom about the interior circumference of the RPV at an elevation at approximately the water level established during normal operation of the BWR; and adjusting the feedwater flow through the inlet and into the sparger to vary the water level to be above, at or below the elevational location of the sparger in response to load-following need

  12. Development of new techniques and enhancement of automatic capability of neutron activation analysis at the Dalat Research Reactor

    International Nuclear Information System (INIS)

    Ho Manh Dung; Ho Van Doanh; Tran Quang Thien; Pham Ngoc Tuan; Pham Ngoc Son; Tran Quoc Duong; Nguyen Van Cuong; Nguyen Minh Tuan; Nguyen Giang; Nguyen Thi Sy

    2017-01-01

    The techniques of neutron activation analysis (NAA) including cyclic, epithermal and prompt-gamma (CNAA, ENAA and PGNAA, respectively) have been developed at the Dalat research reactor (DRR). In addition, the efforts has been spent to improve the automatic capability of irradiation, measurement and data processing of NAA. The renewal of necessary devices/tools for sample preparation have also been done. Eventually, the performance and the utility in terms of sensitivity, accuracy and stability of the analytical results generated by NAA at DRR have significantly been improved. The main results of the project are: 1) Upgrading of the fast irradiation system on Channel 13-2/TC to allow the cyclic irradiations; 2) Development of CNAA; 3) Development of ENAA; 4) Application of k0-method for PGNAA; 5) Investigation of the automatic sample changer (ASC2); 6) Upgrading of Ko-DALAT software for ENAA and modification of k0-IAEA software for CNAA and PGNAA; and 7) Optimization of irradiation and measurement facilities as well as sample preparation devices/tools. A set of procedures of relevant developed techniques in the project were established. The procedures have been evaluated by analysis of the reference materials for which they are meeting the requirements of multi-element analysis for the intended applications. (author)

  13. New intelligent multifunctional SiO2/VO2 composite films with enhanced infrared light regulation performance, solar modulation capability, and superhydrophobicity.

    Science.gov (United States)

    Wang, Chao; Zhao, Li; Liang, Zihui; Dong, Binghai; Wan, Li; Wang, Shimin

    2017-01-01

    Highly transparent, energy-saving, and superhydrophobic nanostructured SiO 2 /VO 2 composite films have been fabricated using a sol-gel method. These composite films are composed of an underlying infrared (IR)-regulating VO 2 layer and a top protective layer that consists of SiO 2 nanoparticles. Experimental results showed that the composite structure could enhance the IR light regulation performance, solar modulation capability, and hydrophobicity of the pristine VO 2 layer. The transmittance of the composite films in visible region ( T lum ) was higher than 60%, which was sufficient to meet the requirements of glass lighting. Compared with pristine VO 2 films and tungsten-doped VO 2 film, the near IR control capability of the composite films was enhanced by 13.9% and 22.1%, respectively, whereas their solar modulation capability was enhanced by 10.9% and 22.9%, respectively. The water contact angles of the SiO 2 /VO 2 composite films were over 150°, indicating superhydrophobicity. The transparent superhydrophobic surface exhibited a high stability toward illumination as all the films retained their initial superhydrophobicity even after exposure to 365 nm light with an intensity of 160 mW . cm -2 for 10 h. In addition, the films possessed anti-oxidation and anti-acid properties. These characteristics are highly advantageous for intelligent windows or solar cell applications, given that they can provide surfaces with anti-fogging, rainproofing, and self-cleaning effects. Our technique offers a simple and low-cost solution to the development of stable and visible light transparent superhydrophobic surfaces for industrial applications.

  14. Increasing emitter efficiency in 3.3-kV enhanced trench IGBTs for higher short-circuit capability

    DEFF Research Database (Denmark)

    Reigosa, Paula Diaz; Iannuzzo, Francesco; Rahimo, Munaf

    2018-01-01

    In this paper, a 3.3-kV Enhanced Trench IGBT has been designed with a high emitter efficiency, for improving its short-circuit robustness. The carrier distribution profile has been shaped in a way that it is possible to increase the electric field at the surface of the IGBT, and thereby, counteract...... the Kirk Effect onset. This design approach is beneficial for mitigating high-frequency oscillations, typically observed in IGBTs under short-circuit conditions. The effectiveness of the proposed design rule is validated by means of mixed-mode device simulations. Then, two IGBTs have been fabricated...... with different emitter efficiencies and tested under short circuit, validating that the high-frequency oscillations can be mitigated, with higher emitter efficiency IGBT designs....

  15. Multifunctional non-viral gene vectors with enhanced stability, improved cellular and nuclear uptake capability, and increased transfection efficiency

    Science.gov (United States)

    Yang, Zhe; Jiang, Zhaozhong; Cao, Zhong; Zhang, Chao; Gao, Di; Luo, Xingen; Zhang, Xiaofang; Luo, Huiyan; Jiang, Qing; Liu, Jie

    2014-08-01

    We have developed a new multifunctional, non-viral gene delivery platform consisting of cationic poly(amine-co-ester) (PPMS) for DNA condensation, PEG shell for nanoparticle stabilization, poly(γ-glutamic acid) (γ-PGA) and mTAT (a cell-penetrating peptide) for accelerated cellular uptake, and a nuclear localization signal peptide (NLS) for enhanced intracellular transport of DNA to the nucleus. In vitro study showed that coating of the binary PPMS/DNA polyplex with γ-PGA promotes cellular uptake of the polyplex particles, particularly by γ-glutamyl transpeptidase (GGT)-positive cells through the GGT-mediated endocytosis pathway. Conjugating PEG to the γ-PGA led to the formation of a ternary PPMS/DNA/PGA-g-PEG polyplex with decreased positive charges on the surface of the polyplex particles and substantially higher stability in serum-containing aqueous medium. The cellular uptake rate was further improved by incorporating mTAT into the ternary polyplex system. Addition of the NLS peptide was designed to facilitate intracellular delivery of the plasmid to the nucleus--a rate-limiting step in the gene transfection process. As a result, compared with the binary PPMS/LucDNA polyplex, the new mTAT-quaternary PPMS/LucDNA/NLS/PGA-g-PEG-mTAT system exhibited reduced cytotoxicity, remarkably faster cellular uptake rate, and enhanced transport of DNA to the nucleus. All these advantageous functionalities contribute to the remarkable gene transfection efficiency of the mTAT-quaternary polyplex both in vitro and in vivo, which exceeds that of the binary polyplex and commercial Lipofectamine™ 2000/DNA lipoplex. The multifunctional mTAT-quaternary polyplex system with improved efficiency and reduced cytotoxicity represents a new type of promising non-viral vectors for the delivery of therapeutic genes to treat tumors.We have developed a new multifunctional, non-viral gene delivery platform consisting of cationic poly(amine-co-ester) (PPMS) for DNA condensation, PEG shell

  16. Methotrexate loaded polyether-copolyester dendrimers for the treatment of gliomas: enhanced efficacy and intratumoral transport capability.

    Science.gov (United States)

    Dhanikula, Renu Singh; Argaw, Anteneh; Bouchard, Jean-Francois; Hildgen, Patrice

    2008-01-01

    Therapeutic benefit in glial tumors is often limited due to low permeability of delivery systems across the blood-brain barrier (BBB), drug resistance, and poor penetration into the tumor tissue. In an attempt to overcome these hurdles, polyether-copolyester (PEPE) dendrimers were evaluated as drug carriers for the treatment of gliomas. Dendrimers were conjugated to d-glucosamine as the ligand for enhancing BBB permeability and tumor targeting. The efficacy of methotrexate (MTX)-loaded dendrimers was established against U87 MG and U 343 MGa cells. Permeability of rhodamine-labeled dendrimers and MTX-loaded dendrimers across the in vitro BBB model and their distribution into avascular human glioma tumor spheroids was also studied. Glucosylated dendrimers were found to be endocytosed in significantly higher amounts than nonglucosylated dendrimers by both the cell lines. IC 50 of MTX after loading in dendrimers was lower than that of the free MTX, suggesting that loading MTX in PEPE dendrimers increased its potency. Similar higher activity of MTX-loaded glucosylated and nonglucosylated dendrimers was found in the reduction of tumor spheroid size. These MTX-loaded dendrimers were able to kill even MTX-resistant cells highlighting their ability to overcome MTX resistance. In addition, the amount of MTX-transported across BBB was three to five times more after loading in the dendrimers. Glucosylation further increased the cumulative permeation of dendrimers across BBB and hence increased the amount of MTX available across it. Glucosylated dendrimers distributed through out the avascular tumor spheroids within 6 h, while nonglucosylated dendrimers could do so in 12 h. The results show that glucosamine can be used as an effective ligand not only for targeting glial tumors but also for enhanced permeability across BBB. Thus, glucosylated PEPE dendrimers can serve as potential delivery system for the treatment of gliomas.

  17. An in vitro-identified high-affinity nucleosome-positioning signal is capable of transiently positioning a nucleosome in vivo

    Directory of Open Access Journals (Sweden)

    Gracey Lia E

    2010-07-01

    Full Text Available Abstract Background The physiological function of eukaryotic DNA occurs in the context of nucleosomal arrays that can expose or obscure defined segments of the genome. Certain DNA sequences are capable of strongly positioning a nucleosome in vitro, suggesting the possibility that favorable intrinsic signals might reproducibly structure chromatin segments. As high-throughput sequencing analyses of nucleosome coverage in vitro and in vivo have become possible, a vigorous debate has arisen over the degree to which intrinsic DNA:nucleosome affinities orchestrate the in vivo positions of nucleosomes, thereby controlling physical accessibility of specific sequences in DNA. Results We describe here the in vivo consequences of placing a synthetic high-affinity nucleosome-positioning signal, the 601 sequence, into a DNA plasmid vector in mice. Strikingly, the 601 sequence was sufficient to position nucleosomes during an early phase after introduction of the DNA into the mice (when the plasmid vector transgene was active. This positioning capability was transient, with a loss of strong positioning at a later time point when the transgenes had become silent. Conclusions These results demonstrate an ability of DNA sequences selected solely for nucleosome affinity to organize chromatin in vivo, and the ability of other mechanisms to overcome these interactions in a dynamic nuclear environment.

  18. Oxygen-enhanced MRI for patients with connective tissue diseases: Comparison with thin-section CT of capability for pulmonary functional and disease severity assessment

    Energy Technology Data Exchange (ETDEWEB)

    Ohno, Yoshiharu, E-mail: yosirad@kobe-u.ac.jp [Advanced Biomedical Imaging Research Center, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Division of Functional and Diagnostic Imaging Research, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Nishio, Mizuho [Advanced Biomedical Imaging Research Center, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Division of Functional and Diagnostic Imaging Research, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Koyama, Hisanobu [Division of Radiology, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Yoshikawa, Takeshi; Matsumoto, Sumiaki [Advanced Biomedical Imaging Research Center, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Division of Functional and Diagnostic Imaging Research, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Seki, Shinichiro [Division of Radiology, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Tsubakimoto, Maho [Division of Radiology, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Department of Radiology, Graduate School of Medical Science, University of the Ryukyus, Nakagami-Gun, Okinawa (Japan); Sugimura, Kazuro [Division of Radiology, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan)

    2014-02-15

    Purpose: To prospectively and directly compare oxygen-enhanced (O{sub 2}-enhanced) MRI with thin-section CT for pulmonary functional loss and disease severity assessment in connective tissue disease (CTD) patients with interstitial lung disease (ILD). Materials and methods: Thin-section CT, O{sub 2}-enhanced MRI, pulmonary function test and serum KL-6 were administered to 36 CTD patients with ILD (23 men, 13 women; mean age: 63.9 years) and nine CTD patients without ILD (six men, and three women; mean age: 62.0 years). A relative-enhancement ratio (RER) map was generated from O{sub 2}-enhanced MRI and mean relative enhancement ratio (MRER) for each subject was calculated from all ROI measurements. CT-assessed disease severity was evaluated with a visual scoring system from each of the thin-section CT data. MRER and CT-assessed disease severities of CTD patients with and without ILD were then statistically compared. To assess capability for pulmonary functional loss and disease severity assessment in CTD patients, correlations of MRER and CT-assessed disease severity with pulmonary functional parameters and serum KL-6 in all subjects were statistically determined. Results: MRER and CT-assessed disease severity showed significant differences between CTD patients with (MRER: 0.15 ± 0.08, CT-assessed disease severity: 13.0 ± 7.4%) and without ILD (MRER: 0.25 ± 0.06, p = 0.0011; CT-assessed disease severity: 1.6 ± 1.6%, p < 0.0001). MRER and CT-assessed disease severity correlated significantly with pulmonary functional parameters and serum KL-6 in all subjects (0.61 ≤ r ≤ 0.79, p < 0.05). Conclusion: O{sub 2}-enhanced MRI was found to be as useful as thin-section CT for pulmonary functional loss and disease severity assessment of CTD patients with ILD.

  19. Oxygen-enhanced MRI for patients with connective tissue diseases: Comparison with thin-section CT of capability for pulmonary functional and disease severity assessment

    International Nuclear Information System (INIS)

    Ohno, Yoshiharu; Nishio, Mizuho; Koyama, Hisanobu; Yoshikawa, Takeshi; Matsumoto, Sumiaki; Seki, Shinichiro; Tsubakimoto, Maho; Sugimura, Kazuro

    2014-01-01

    Purpose: To prospectively and directly compare oxygen-enhanced (O 2 -enhanced) MRI with thin-section CT for pulmonary functional loss and disease severity assessment in connective tissue disease (CTD) patients with interstitial lung disease (ILD). Materials and methods: Thin-section CT, O 2 -enhanced MRI, pulmonary function test and serum KL-6 were administered to 36 CTD patients with ILD (23 men, 13 women; mean age: 63.9 years) and nine CTD patients without ILD (six men, and three women; mean age: 62.0 years). A relative-enhancement ratio (RER) map was generated from O 2 -enhanced MRI and mean relative enhancement ratio (MRER) for each subject was calculated from all ROI measurements. CT-assessed disease severity was evaluated with a visual scoring system from each of the thin-section CT data. MRER and CT-assessed disease severities of CTD patients with and without ILD were then statistically compared. To assess capability for pulmonary functional loss and disease severity assessment in CTD patients, correlations of MRER and CT-assessed disease severity with pulmonary functional parameters and serum KL-6 in all subjects were statistically determined. Results: MRER and CT-assessed disease severity showed significant differences between CTD patients with (MRER: 0.15 ± 0.08, CT-assessed disease severity: 13.0 ± 7.4%) and without ILD (MRER: 0.25 ± 0.06, p = 0.0011; CT-assessed disease severity: 1.6 ± 1.6%, p < 0.0001). MRER and CT-assessed disease severity correlated significantly with pulmonary functional parameters and serum KL-6 in all subjects (0.61 ≤ r ≤ 0.79, p < 0.05). Conclusion: O 2 -enhanced MRI was found to be as useful as thin-section CT for pulmonary functional loss and disease severity assessment of CTD patients with ILD

  20. Capability ethics

    OpenAIRE

    Robeyns, Ingrid

    2012-01-01

    textabstractThe capability approach is one of the most recent additions to the landscape of normative theories in ethics and political philosophy. Yet in its present stage of development, the capability approach is not a full-blown normative theory, in contrast to utilitarianism, deontological theories, virtue ethics, or pragmatism. As I will argue in this chapter, at present the core of the capability approach is an account of value, which together with some other (more minor) normative comm...

  1. Denitrifying capabilities of Tetrasphaera and their contribution towards nitrous oxide production in enhanced biological phosphorus removal processes.

    Science.gov (United States)

    Marques, Ricardo; Ribera-Guardia, Anna; Santos, Jorge; Carvalho, Gilda; Reis, Maria A M; Pijuan, Maite; Oehmen, Adrian

    2018-06-15

    Denitrifying enhanced biological phosphorus removal (EBPR) systems can be an efficient means of removing phosphate (P) and nitrate (NO 3 - ) with low carbon source and oxygen requirements. Tetrasphaera is one of the most abundant polyphosphate accumulating organisms present in EBPR systems, but their capacity to achieve denitrifying EBPR has not previously been determined. An enriched Tetrasphaera culture, comprising over 80% of the bacterial biovolume was obtained in this work. Despite the denitrification capacity of Tetrasphaera, this culture achieved only low levels of anoxic P-uptake. Batch tests with different combinations of NO 3 - , nitrite (NO 2 - ) and nitrous oxide (N 2 O) revealed lower N 2 O accumulation by Tetrasphaera as compared to Accumulibacter and Competibacter when multiple electron acceptors were added. Electron competition was observed during the addition of multiple nitrogen electron acceptors species, where P uptake appeared to be slightly favoured over glycogen production in these situations. This study increases our understanding of the role of Tetrasphaera-related organisms in denitrifying EBPR systems. Copyright © 2018 Elsevier Ltd. All rights reserved.

  2. The evolution of alliance capabilities

    NARCIS (Netherlands)

    Heimeriks, K.H.; Duysters, G.M.; Vanhaverbeke, W.P.M.

    2004-01-01

    This paper assesses the effectiveness and differential performance effects of learning mechanisms on the evolution of alliance capabilities. Relying on the concept of capability lifecycles, prior research has suggested that different capability levels could be identified in which different

  3. Dynamic Capabilities

    DEFF Research Database (Denmark)

    Grünbaum, Niels Nolsøe; Stenger, Marianne

    2013-01-01

    The findings reveal a positive relationship between dynamic capabilities and innovation performance in the case enterprises, as we would expect. It was, however, not possible to establish a positive relationship between innovation performance and profitability. Nor was there any positive...... relationship between dynamic capabilities and profitability....

  4. Capability ethics

    NARCIS (Netherlands)

    I.A.M. Robeyns (Ingrid)

    2012-01-01

    textabstractThe capability approach is one of the most recent additions to the landscape of normative theories in ethics and political philosophy. Yet in its present stage of development, the capability approach is not a full-blown normative theory, in contrast to utilitarianism, deontological

  5. Enterocin A mutants identified by saturation mutagenesis enhance potency towards vancomycin-resistant Enterococci.

    Science.gov (United States)

    McClintock, Maria K; Kaznessis, Yiannis N; Hackel, Benjamin J

    2016-02-01

    Vancomycin-resistant Enterococci infections are a significant clinical problem. One proposed solution is to use probiotics, such as lactic acid bacteria, to produce antimicrobial peptides at the site of infection. Enterocin A, a class 2a bacteriocin, exhibits inhibitory activity against E. faecium and E. faecalis, which account for 86% of vancomycin-resistant Enterococci infections. In this study, we aimed to engineer enterocin A mutants with enhanced potency within a lactic acid bacterial production system. Peptide mutants resulting from saturation mutagenesis at sites A24 and T27 were efficiently screened in a 96-well plate assay for inhibition of pathogen growth. Several mutants exhibit increased potency relative to wild-type enterocin A in both liquid- and solid-medium growth assays. In particular, A24P and T27G exhibit enhanced inhibition of multiple strains of E. faecium and E. faecalis, including clinically isolated vancomycin-resistant strains. A24P and T27G enhance killing of E. faecium 8 by 13 ± 3- and 18 ± 4-fold, respectively. The engineered enterocin A/lactic acid bacteria systems offer significant potential to combat antibiotic-resistant infections. © 2015 Wiley Periodicals, Inc.

  6. Gossiping Capabilities

    DEFF Research Database (Denmark)

    Mogensen, Martin; Frey, Davide; Guerraoui, Rachid

    Gossip-based protocols are now acknowledged as a sound basis to implement collaborative high-bandwidth content dissemination: content location is disseminated through gossip, the actual contents being subsequently pulled. In this paper, we present HEAP, HEterogeneity Aware gossip Protocol, where...... nodes dynamically adjust their contribution to gossip dissemination according to their capabilities. Using a continuous, itself gossip-based, approximation of relative capabilities, HEAP dynamically leverages the most capable nodes by (a) increasing their fanouts (while decreasing by the same proportion...... declare a high capability in order to augment their perceived quality without contributing accordingly. We evaluate HEAP in the context of a video streaming application on a 236 PlanetLab nodes testbed. Our results shows that HEAP improves the quality of the streaming by 25% over a standard gossip...

  7. Identifying problems and generating recommendations for enhancing complex systems: applying the abstraction hierarchy framework as an analytical tool.

    Science.gov (United States)

    Xu, Wei

    2007-12-01

    This study adopts J. Rasmussen's (1985) abstraction hierarchy (AH) framework as an analytical tool to identify problems and pinpoint opportunities to enhance complex systems. The process of identifying problems and generating recommendations for complex systems using conventional methods is usually conducted based on incompletely defined work requirements. As the complexity of systems rises, the sheer mass of data generated from these methods becomes unwieldy to manage in a coherent, systematic form for analysis. There is little known work on adopting a broader perspective to fill these gaps. AH was used to analyze an aircraft-automation system in order to further identify breakdowns in pilot-automation interactions. Four steps follow: developing an AH model for the system, mapping the data generated by various methods onto the AH, identifying problems based on the mapped data, and presenting recommendations. The breakdowns lay primarily with automation operations that were more goal directed. Identified root causes include incomplete knowledge content and ineffective knowledge structure in pilots' mental models, lack of effective higher-order functional domain information displayed in the interface, and lack of sufficient automation procedures for pilots to effectively cope with unfamiliar situations. The AH is a valuable analytical tool to systematically identify problems and suggest opportunities for enhancing complex systems. It helps further examine the automation awareness problems and identify improvement areas from a work domain perspective. Applications include the identification of problems and generation of recommendations for complex systems as well as specific recommendations regarding pilot training, flight deck interfaces, and automation procedures.

  8. Genome-wide screens for in vivo Tinman binding sites identify cardiac enhancers with diverse functional architectures.

    Directory of Open Access Journals (Sweden)

    Hong Jin

    Full Text Available The NK homeodomain factor Tinman is a crucial regulator of early mesoderm patterning and, together with the GATA factor Pannier and the Dorsocross T-box factors, serves as one of the key cardiogenic factors during specification and differentiation of heart cells. Although the basic framework of regulatory interactions driving heart development has been worked out, only about a dozen genes involved in heart development have been designated as direct Tinman target genes to date, and detailed information about the functional architectures of their cardiac enhancers is lacking. We have used immunoprecipitation of chromatin (ChIP from embryos at two different stages of early cardiogenesis to obtain a global overview of the sequences bound by Tinman in vivo and their linked genes. Our data from the analysis of ~50 sequences with high Tinman occupancy show that the majority of such sequences act as enhancers in various mesodermal tissues in which Tinman is active. All of the dorsal mesodermal and cardiac enhancers, but not some of the others, require tinman function. The cardiac enhancers feature diverse arrangements of binding motifs for Tinman, Pannier, and Dorsocross. By employing these cardiac and non-cardiac enhancers in machine learning approaches, we identify a novel motif, termed CEE, as a classifier for cardiac enhancers. In vivo assays for the requirement of the binding motifs of Tinman, Pannier, and Dorsocross, as well as the CEE motifs in a set of cardiac enhancers, show that the Tinman sites are essential in all but one of the tested enhancers; although on occasion they can be functionally redundant with Dorsocross sites. The enhancers differ widely with respect to their requirement for Pannier, Dorsocross, and CEE sites, which we ascribe to their different position in the regulatory circuitry, their distinct temporal and spatial activities during cardiogenesis, and functional redundancies among different factor binding sites.

  9. RNA Interference Screen to Identify Pathways That Enhance or Reduce Nonviral Gene Transfer During Lipofection

    OpenAIRE

    Barker, Gregory A; Diamond, Scott L

    2008-01-01

    Some barriers to DNA lipofection are well characterized; however, there is as yet no method of finding unknown pathways that impact the process. A druggable genome small-interfering RNA (siRNA) screen against 5,520 genes was tested for its effect on lipofection of human aortic endothelial cells (HAECs). We found 130 gene targets which, when silenced by pooled siRNAs (three siRNAs per gene), resulted in enhanced luminescence after lipofection (86 gene targets showed reduced expression). In con...

  10. Recognizing the Capability of National and Traditional Images in Identifying the Packaging of Products for Export (Case Study: Iranian Edible Export

    Directory of Open Access Journals (Sweden)

    Leila Minaei

    2018-03-01

    Full Text Available Identity is a complicated and significant issue in contemporary era in such a way that attention to its status forms the basis of the present study. One of the areas that can play o role in representing identity is relying on images used in packaging. Packaging is an applied art known as essential in contemporary societies and it is present everywhere. Packaging with national and traditional visual components is an important way to create and transfer identity. The necessity of this research is to reach patterns and theoretical viewpoints related to the concept of identity and to focus on recognizing its aspects through the images on the packaging of products for export. On this basis, the present study was conducted to recognize identifying elements used in the packaging of Iranian edible products for export. This basic research is descriptive-analytic in nature. Observation and combination were used for data gathering. Along the conducted study and based on the findings of the research, the results show that among all identity aspects in this research, by representation geography aspect, Persian language and writing, Iranian arts and historical aspect are respectively the most effective agents in identifying the packaging of Iranian products for export.

  11. A sensitive HIV-1 envelope induced fusion assay identifies fusion enhancement of thrombin

    International Nuclear Information System (INIS)

    Cheng, De-Chun; Zhong, Guo-Cai; Su, Ju-Xiang; Liu, Yan-Hong; Li, Yan; Wang, Jia-Ye; Hattori, Toshio; Ling, Hong; Zhang, Feng-Min

    2010-01-01

    To evaluate the interaction between HIV-1 envelope glycoprotein (Env) and target cell receptors, various cell-cell-fusion assays have been developed. In the present study, we established a novel fusion system. In this system, the expression of the sensitive reporter gene, firefly luciferase (FL) gene, in the target cells was used to evaluate cell fusion event. Simultaneously, constitutively expressed Renilla luciferase (RL) gene was used to monitor effector cell number and viability. FL gave a wider dynamic range than other known reporters and the introduction of RL made the assay accurate and reproducible. This system is especially beneficial for investigation of potential entry-influencing agents, for its power of ruling out the false inhibition or enhancement caused by the artificial cell-number variation. As a case study, we applied this fusion system to observe the effect of a serine protease, thrombin, on HIV Env-mediated cell-cell fusion and have found the fusion enhancement activity of thrombin over two R5-tropic HIV strains.

  12. Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

    DEFF Research Database (Denmark)

    Demenais, Florence; Margaritte-Jeannin, Patricia; Barnes, Kathleen C

    2018-01-01

    We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known...

  13. Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

    NARCIS (Netherlands)

    Demenais, Florence; Margaritte-Jeannin, Patricia; Barnes, Kathleen C; Cookson, William O C; Altmüller, Janine; Ang, Wei; Barr, R Graham; Beaty, Terri H; Becker, Allan B; Beilby, John; Bisgaard, Hans; Bjornsdottir, Unnur Steina; Bleecker, Eugene; Bønnelykke, Klaus; Boomsma, Dorret I; Bouzigon, Emmanuelle; Brightling, Christopher E; Brossard, Myriam; Brusselle, Guy G; Burchard, Esteban; Burkart, Kristin M; Bush, Andrew; Chan-Yeung, Moira; Chung, Kian Fan; Couto Alves, Alexessander; Curtin, John A; Custovic, Adnan; Daley, Denise; de Jongste, Johan C; Del-Rio-Navarro, Blanca E; Donohue, Kathleen M; Duijts, Liesbeth; Eng, Celeste; Eriksson, Johan G; Farrall, Martin; Fedorova, Yuliya; Feenstra, Bjarke; Ferreira, Manuel A; Freidin, Maxim B; Gajdos, Zofia; Gauderman, Jim; Gehring, Ulrike; Geller, Frank; Genuneit, Jon; Gharib, Sina A; Gilliland, Frank; Granell, Raquel; Graves, Penelope E; Gudbjartsson, Daniel F; Haahtela, Tari; Heckbert, Susan R; Heederik, Dick; Heinrich, Joachim; Heliövaara, Markku; Henderson, John; Himes, Blanca E; Hirose, Hiroshi; Hirschhorn, Joel N; Hofman, Albert; Holt, Patrick; Hottenga, Jouke; Hudson, Thomas J; Hui, Jennie; Imboden, Medea; Ivanov, Vladimir; Jaddoe, Vincent W V; James, Alan; Janson, Christer; Jarvelin, Marjo-Riitta; Jarvis, Deborah; Jones, Graham; Jonsdottir, Ingileif; Jousilahti, Pekka; Kabesch, Michael; Kähönen, Mika; Kantor, David B; Karunas, Alexandra S; Khusnutdinova, Elza; Koppelman, Gerard H; Kozyrskyj, Anita L; Kreiner, Eskil; Kubo, Michiaki; Kumar, Rajesh; Kumar, Ashish; Kuokkanen, Mikko; Lahousse, Lies; Laitinen, Tarja; Laprise, Catherine; Lathrop, Mark; Lau, Susanne; Lee, Young-Ae; Lehtimäki, Terho; Letort, Sébastien; Levin, Albert M; Li, Guo; Liang, Liming; Loehr, Laura R; London, Stephanie J; Loth, Daan W; Manichaikul, Ani; Marenholz, Ingo; Martinez, Fernando J; Matheson, Melanie C; Mathias, Rasika A; Matsumoto, Kenji; Mbarek, Hamdi; McArdle, Wendy L; Melbye, Mads; Melén, Erik; Meyers, Deborah; Michel, Sven; Mohamdi, Hamida; Musk, Arthur W; Myers, Rachel A; Nieuwenhuis, Maartje A E; Noguchi, Emiko; O'Connor, George T; Ogorodova, Ludmila M; Palmer, Cameron D; Palotie, Aarno; Park, Julie E; Pennell, Craig E; Pershagen, Göran; Polonikov, Alexey; Postma, Dirkje S; Probst-Hensch, Nicole; Puzyrev, Valery P; Raby, Benjamin A; Raitakari, Olli T; Ramasamy, Adaikalavan; Rich, Stephen S; Robertson, Colin F; Romieu, Isabelle; Salam, Muhammad T; Salomaa, Veikko; Schlünssen, Vivi; Scott, Robert; Selivanova, Polina A; Sigsgaard, Torben; Simpson, Angela; Siroux, Valérie; Smith, Lewis J; Solodilova, Maria; Standl, Marie; Stefansson, Kari; Strachan, David P; Stricker, Bruno H; Takahashi, Atsushi; Thompson, Philip J; Thorleifsson, Gudmar; Thorsteinsdottir, Unnur; Tiesler, Carla M T; Torgerson, Dara G; Tsunoda, Tatsuhiko; Uitterlinden, André G; van der Valk, Ralf J P; Vaysse, Amaury; Vedantam, Sailaja; von Berg, Andrea; von Mutius, Erika; Vonk, Judith M; Waage, Johannes; Wareham, Nick J; Weiss, Scott T; White, Wendy B; Wickman, Magnus; Widén, Elisabeth; Willemsen, Gonneke; Williams, L Keoki; Wouters, Inge M; Yang, James J; Zhao, Jing Hua; Moffatt, Miriam F; Ober, Carole; Nicolae, Dan L

    We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma

  14. Empirical study on the feasibility of measures for public self-protection capability enhancement; Empirische Untersuchung der Realisierbarkeit von Massnahmen zur Erhoehung der Selbstschutzfaehigkeit der Bevoelkerung

    Energy Technology Data Exchange (ETDEWEB)

    Goersch, Henning G.; Werner, Ute

    2011-07-01

    The empirical study on the feasibility of measures for public self-protection capability enhancement covers the following issues with several sections: (1) Introduction: scope of the study; structure of the study. (2) Issue coherence: self-protection; reduction and prevention of damage by personal emergency preparedness, personal emergency preparedness in Germany. (3) Solution coherence: scientific approaches, development of practical problem solution approaches, proposal of a promotion system. (4) Empirical studies: Promotion system evaluation by experts; questioning of the public; Delphi-study on minimum standards in emergency preparedness; local networks in emergency preparedness. (5) Evaluation of models for personal emergency preparedness (M3P). (6) Integration of all research results into the approach of emergency preparedness: scope; recommendations, conclusions.

  15. Enhanced biodegradation of diesel oil by a newly identified Rhodococcus baikonurensis EN3 in the presence of mycolic acid.

    Science.gov (United States)

    Lee, M; Kim, M K; Singleton, I; Goodfellow, M; Lee, S-T

    2006-02-01

    The aim of the present study was to isolate and characterize a bacterium, strain EN3, capable of using diesel oil as a major carbon and energy source, and to analyse the enhancement of diesel oil degradation by this organism using synthetic mycolic acid (2-hexyl-3-hydroxyldecanoic acid). An actinomycete with the ability to degrade diesel oil was isolated from oil contaminated soil and characterized. The strain had phenotypic properties consistent with its classification in the genus Rhodococcus showing a 16S rRNA gene similarity of 99.7% with Rhodococcus baikonurensis DSM 44587(T). The ability of the characterized strain to degrade diesel oil at various concentrations (1000, 5000, 10 000 and 20 000 mg l(-1)) was determined. The effect of synthetic mycolic acid on the biodegradation of diesel oil was investigated at the 20 000 mg l(-1) concentration; the surfactant was added to the flask cultures at three different concentrations (10, 50 and 100 mg l(-1)) and degradation followed over 7 days. Enhanced degradation was found at all three concentrations of the surfactant. In addition, the enhancement of diesel oil degradation by other surfactants was observed. The synthetic mycolic acid has potential for the remediation of petroleum-contaminated sites from both an economic and applied perspective as it can stimulate biodegradation at low concentrations. This study showed that the synthesized mycolic acid can be used for potential applications in the bioremediation industries, for example, in oil spill clean-up, diesel fuel remediation and biostimulation.

  16. Enhancement of DFIG-Wind Turbine’s LVRT capability using novel DVR based Odd-nary Cascaded Asymmetric Multi-Level Inverter

    Directory of Open Access Journals (Sweden)

    A.D. Falehi

    2017-06-01

    Full Text Available One of the most prominent issues relevant to Doubly Fed Induction Generator (DFIG is augmentation of its Low Voltage Ride Through (LVRT capability. Dynamic Voltage Restorer (DVR is a series kind of Distributed-Flexible AC Transmission Systems (D-FACTS that is here occupied to preserve the DFIG from the voltage sag whenever a fault to be occurred in the power system. Multi-Level Inverter (MLI is the beating-heart of DVR with unique responsibility of synthesizing a staircase sinusoidal voltage from the DC voltage sources. In this regard, it is immensely important a high performance and cost-effective MLI to be embedded into the DVR. In this paper, a novel MLI is introduced to provide a staircase sinusoidal voltage with high level numbers against less switch numbers as compared to the other kinds of MLIs. By adding the bi-directional switches and capacitors of sub-MLI as well as amount of DC sources, the held forth MLI can also operate as so-called “Odd-nary” Cascaded Asymmetric Multi-Level Inverter (OCAMLI. The performance of proposed DVR based on OCAMLI i.e., DVR-OCAMLI has been thoroughly evaluated under deep and shallow balanced and unbalanced voltage sags so that its LVRT capability to be cleared up. To more scrutinize the performance of DVR-OCAMLI, it has been withal dealt with under severe and slight voltage swells as well as harmonic voltage. The accuracy and performance of DVR-OCAMLI has been furthermore compared with conventional DVR. To sum up, the relevant analytical study along with the simulation results has transparently corroborated the performance of OCAMLI as compared to other MLIs. Meanwhile, the DVR-OCAMLI has significantly compensated deep and shallow symmetric and asymmetric voltage sags to enhance the LVRT capability of DFIG; correspondingly, the severe and slight symmetric and asymmetric voltage swells as well as voltage harmonic have been exceptionally compensated as compared to conventional DVR.

  17. High-throughput sequencing enhanced phage display identifies peptides that bind mycobacteria

    CSIR Research Space (South Africa)

    Ngubane, NAC

    2013-11-01

    Full Text Available . The displayed peptides are flanked by two cysteine residues, which are oxidized during phage assembly to a disulfide bond, resulting in a loop constrained peptide. We initially used the traditional clone picking method to identify the enriched clones... of the library, 1.236109 heptapeptides, it represented sufficient depth to measure the quantitative enrich- ment of relevant peptides. To confirm successful enrichment during selection, we characterized the reduction in diversity of the pool in the consecutive...

  18. Identifying Triple-Negative Breast Cancer Using Background Parenchymal Enhancement Heterogeneity on Dynamic Contrast-Enhanced MRI: A Pilot Radiomics Study.

    Directory of Open Access Journals (Sweden)

    Jeff Wang

    Full Text Available To determine the added discriminative value of detailed quantitative characterization of background parenchymal enhancement in addition to the tumor itself on dynamic contrast-enhanced (DCE MRI at 3.0 Tesla in identifying "triple-negative" breast cancers.In this Institutional Review Board-approved retrospective study, DCE-MRI of 84 women presenting 88 invasive carcinomas were evaluated by a radiologist and analyzed using quantitative computer-aided techniques. Each tumor and its surrounding parenchyma were segmented semi-automatically in 3-D. A total of 85 imaging features were extracted from the two regions, including morphologic, densitometric, and statistical texture measures of enhancement. A small subset of optimal features was selected using an efficient sequential forward floating search algorithm. To distinguish triple-negative cancers from other subtypes, we built predictive models based on support vector machines. Their classification performance was assessed with the area under receiver operating characteristic curve (AUC using cross-validation.Imaging features based on the tumor region achieved an AUC of 0.782 in differentiating triple-negative cancers from others, in line with the current state of the art. When background parenchymal enhancement features were included, the AUC increased significantly to 0.878 (p<0.01. Similar improvements were seen in nearly all subtype classification tasks undertaken. Notably, amongst the most discriminating features for predicting triple-negative cancers were textures of background parenchymal enhancement.Considering the tumor as well as its surrounding parenchyma on DCE-MRI for radiomic image phenotyping provides useful information for identifying triple-negative breast cancers. Heterogeneity of background parenchymal enhancement, characterized by quantitative texture features on DCE-MRI, adds value to such differentiation models as they are strongly associated with the triple-negative subtype

  19. Capability approach

    DEFF Research Database (Denmark)

    Jensen, Niels Rosendal; Kjeldsen, Christian Christrup

    Lærebogen er den første samlede danske præsentation af den af Amartya Sen og Martha Nussbaum udviklede Capability Approach. Bogen indeholder en præsentation og diskussion af Sen og Nussbaums teoretiske platform. I bogen indgår eksempler fra såvel uddannelse/uddannelsespolitik, pædagogik og omsorg....

  20. Identifying opportunities to enhance environmental cleaning in 23 acute care hospitals .

    Science.gov (United States)

    Carling, P C; Parry, M F; Von Beheren, S M

    2008-01-01

    The quality of environmental hygiene in hospitals is under increasing scrutiny from both healthcare providers and consumers because the prevalence of serious infections due to multidrug-resistant pathogens has reached alarming levels. On the basis of the results from a small number of hospitals, we undertook a study to evaluate the thoroughness of disinfection and cleaning in the patient's immediate environment and to identify opportunities for improvement in a diverse group of acute care hospitals. Prospective multicenter study to evaluate the thoroughness of terminal room cleaning in hospitals using a novel targeting method to mimic the surface contamination of objects in the patient's immediate environment. Twenty-three acute care hospitals. The overall thoroughness of terminal cleaning, expressed as a percentage of surfaces evaluated, was 49% (range for all 23 hospitals, 35%-81%). Despite the tight clustering of overall cleaning rates in 21 of the hospitals, there was marked variation within object categories, which was particularly notable with respect to the cleaning of toilet handholds, bedpan cleaners, light switches, and door knobs (mean cleaning rates, less than 30%; institutional ranges, 0%-90%). Sinks, toilet seats, and tray tables, in contrast, were consistently relatively well cleaned (mean cleaning rates, over 75%). Patient telephones, nurse call devices, and bedside rails were inconsistently cleaned. We identified significant opportunities in all participating hospitals to improve the cleaning of frequently touched objects in the patient's immediate environment. The information obtained from such assessments can be used to develop focused administrative and educational interventions that incorporate ongoing feedback to the environmental services staff, to improve cleaning and disinfection practices in healthcare institutions.

  1. Promoter-enhancer interactions identified from Hi-C data using probabilistic models and hierarchical topological domains.

    Science.gov (United States)

    Ron, Gil; Globerson, Yuval; Moran, Dror; Kaplan, Tommy

    2017-12-21

    Proximity-ligation methods such as Hi-C allow us to map physical DNA-DNA interactions along the genome, and reveal its organization into topologically associating domains (TADs). As the Hi-C data accumulate, computational methods were developed for identifying domain borders in multiple cell types and organisms. Here, we present PSYCHIC, a computational approach for analyzing Hi-C data and identifying promoter-enhancer interactions. We use a unified probabilistic model to segment the genome into domains, which we then merge hierarchically and fit using a local background model, allowing us to identify over-represented DNA-DNA interactions across the genome. By analyzing the published Hi-C data sets in human and mouse, we identify hundreds of thousands of putative enhancers and their target genes, and compile an extensive genome-wide catalog of gene regulation in human and mouse. As we show, our predictions are highly enriched for ChIP-seq and DNA accessibility data, evolutionary conservation, eQTLs and other DNA-DNA interaction data.

  2. ENTREPRENEURIAL CAPABILITIES

    DEFF Research Database (Denmark)

    Rasmussen, Lauge Baungaard; Nielsen, Thorkild

    2003-01-01

    The aim of this article is to analyse entrepreneurship from an action research perspective. What is entrepreneurship about? Which are the fundamental capabilities and processes of entrepreneurship? To answer these questions the article includes a case study of a Danish entrepreneur and his networ....... Finally, the article discuss, how more long term action research methods could be integrated into the entrepreneurial processes and the possible impacts of such an implementation?...

  3. Fault Ride-through Capability Enhancement of Voltage Source Converter-High Voltage Direct Current Systems with Bridge Type Fault Current Limiters

    Directory of Open Access Journals (Sweden)

    Md Shafiul Alam

    2017-11-01

    Full Text Available This paper proposes the use of bridge type fault current limiters (BFCLs as a potential solution to reduce the impact of fault disturbance on voltage source converter-based high voltage DC (VSC-HVDC systems. Since VSC-HVDC systems are vulnerable to faults, it is essential to enhance the fault ride-through (FRT capability with auxiliary control devices like BFCLs. BFCL controllers have been developed to limit the fault current during the inception of system disturbances. Real and reactive power controllers for the VSC-HVDC have been developed based on current control mode. DC link voltage control has been achieved by a feedback mechanism such that net power exchange with DC link capacitor is zero. A grid-connected VSC-HVDC system and a wind farm integrated VSC-HVDC system along with the proposed BFCL and associated controllers have been implemented in a real time digital simulator (RTDS. Symmetrical three phase as well as different types of unsymmetrical faults have been applied in the systems in order to show the effectiveness of the proposed BFCL solution. DC link voltage fluctuation, machine speed and active power oscillation have been greatly suppressed with the proposed BFCL. Another significant feature of this work is that the performance of the proposed BFCL in VSC-HVDC systems is compared to that of series dynamic braking resistor (SDBR. Comparative results show that the proposed BFCL is superior over SDBR in limiting fault current as well as improving system fault ride through (FRT capability.

  4. Mouse transgenesis identifies conserved functional enhancers and cis-regulatory motif in the vertebrate LIM homeobox gene Lhx2 locus.

    Directory of Open Access Journals (Sweden)

    Alison P Lee

    Full Text Available The vertebrate Lhx2 is a member of the LIM homeobox family of transcription factors. It is essential for the normal development of the forebrain, eye, olfactory system and liver as well for the differentiation of lymphoid cells. However, despite the highly restricted spatio-temporal expression pattern of Lhx2, nothing is known about its transcriptional regulation. In mammals and chicken, Crb2, Dennd1a and Lhx2 constitute a conserved linkage block, while the intervening Dennd1a is lost in the fugu Lhx2 locus. To identify functional enhancers of Lhx2, we predicted conserved noncoding elements (CNEs in the human, mouse and fugu Crb2-Lhx2 loci and assayed their function in transgenic mouse at E11.5. Four of the eight CNE constructs tested functioned as tissue-specific enhancers in specific regions of the central nervous system and the dorsal root ganglia (DRG, recapitulating partial and overlapping expression patterns of Lhx2 and Crb2 genes. There was considerable overlap in the expression domains of the CNEs, which suggests that the CNEs are either redundant enhancers or regulating different genes in the locus. Using a large set of CNEs (810 CNEs associated with transcription factor-encoding genes that express predominantly in the central nervous system, we predicted four over-represented 8-mer motifs that are likely to be associated with expression in the central nervous system. Mutation of one of them in a CNE that drove reporter expression in the neural tube and DRG abolished expression in both domains indicating that this motif is essential for expression in these domains. The failure of the four functional enhancers to recapitulate the complete expression pattern of Lhx2 at E11.5 indicates that there must be other Lhx2 enhancers that are either located outside the region investigated or divergent in mammals and fishes. Other approaches such as sequence comparison between multiple mammals are required to identify and characterize such enhancers.

  5. Enhanced Rate Capability of Polymer-Derived SiCN Anode Material for Electrochemical Storage of Lithium with 3-D Carbon Nanotube Network Dispersed in Nanoscale.

    Science.gov (United States)

    Zhang, Junwei; Xu, Caihong; Liu, Zhaoping; Wang, Wei; Xin, Xing; Shen, Lu; Zhou, Xiaobing; Zhou, Jie; Huang, Qing

    2015-04-01

    Electrochemical performances of multi-walled carbon nanotubes (CNT)-SiCN composite have been investigated. The sample was synthesized by a simple ultrasonication assisted method combined with high-temperature pyrolysis and characterized by Fourier transform infrared spectra, Raman spectra, X-ray diffraction, field emission scanning electron microscopy and transmission electronic microscopy. In this composite, CNT were uniformly distributed in the SiCN ceramic matrix, it retained the structural integrity during the polymer-ceramic conversion and had a relatively strong bonding with the SiCN ceramic matrix. When tested as anode in the half cell, the obtained composite exhibited enhanced rate capability and cyclic capacity than that of pristine SiCN powder, CNT and graphite, it could supply a capacity of 222.7 mA h/g when charged at 2000 mA/g, while the SiCN anode showed nearly no capacity even at the low current density of 200 mA/g. It is expected that the CNT-SiCN composite, perhaps the series of CNT-PDC composites, may be prospective candidate for high power applications.

  6. An Empirical Study of Capability Development within Product Innovation Projects

    Directory of Open Access Journals (Sweden)

    Alireza Javanmardi Kashan

    2015-04-01

    Full Text Available The objective of this paper is to develop insights into firms’ strategic capability development processes within product innovation projects. In particular, the research aims at investigating the interactions among product innovation, knowledge processes, and capability development within firms. Building on qualitative data from the auto-industry, our analysis reveals that across four product innovation projects, the case company developed architectural knowledge and capability. Findings reveal that, along with changes at each level of product architecture, “design knowledge” and “design capability” have been developed at the same level of product architecture, leading to capability development at that level. Furthermore, findings suggest that such capability transformation resulting from knowledge and capability creation over the course of case projects leads to modularization of product architecture. Overall, the research contributes to identifying and emphasizing the role of micro processes in capability development and renewal, which in turn enhances our understanding of strategic capability development processes.

  7. Global transcriptomic profiling of aspen trees under elevated [CO2] to identify potential molecular mechanisms responsible for enhanced radial growth.

    Science.gov (United States)

    Wei, Hairong; Gou, Jiqing; Yordanov, Yordan; Zhang, Huaxin; Thakur, Ramesh; Jones, Wendy; Burton, Andrew

    2013-03-01

    Aspen (Populus tremuloides) trees growing under elevated [CO(2)] at a free-air CO(2) enrichment (FACE) site produced significantly more biomass than control trees. We investigated the molecular mechanisms underlying the observed increase in biomass by producing transcriptomic profiles of the vascular cambium zone (VCZ) and leaves, and then performed a comparative study to identify significantly changed genes and pathways after 12 years exposure to elevated [CO(2)]. In leaves, elevated [CO(2)] enhanced expression of genes related to Calvin cycle activity and linked pathways. In the VCZ, the pathways involved in cell growth, cell division, hormone metabolism, and secondary cell wall formation were altered while auxin conjugation, ABA synthesis, and cytokinin glucosylation and degradation were inhibited. Similarly, the genes involved in hemicellulose and pectin biosynthesis were enhanced, but some genes that catalyze important steps in lignin biosynthesis pathway were inhibited. Evidence from systemic analysis supported the functioning of multiple molecular mechanisms that underpin the enhanced radial growth in response to elevated [CO(2)].

  8. Capability Development in an Offshoring Context

    DEFF Research Database (Denmark)

    Jaura, Manya

    Capability development can be defined as deliberate firm-level investment involving a search and learning process aimed at modifying or enhancing existing capabilities. Increasingly, firms are relocating advanced services to offshore locations resulting in the challenge of capability development ...

  9. Materials interaction tests to identify base and coating materials for an enhanced in-vessel core catcher design

    Energy Technology Data Exchange (ETDEWEB)

    Rempe, J.L.; Knudson, D.L.; Condie, K.G.; Swank, W.D. [Idaho National Engineering and Environmental Laboratory, Idaho Falls ID (United States); Cheung, F.B. [Pennsylvania State University, Department of Mechanical and Nuclear Engineering, University Park PA (United States); Suh, K.Y. [Seoul National University, Department of Nuclear Engineering, Seoul (Korea, Republic of); Kim, S.B. [Korea Atomic Energy Research Institute, Severe Accident Research Project, Taejon (Korea, Republic of)

    2004-07-01

    An enhanced in-vessel core catcher is being designed and evaluated, it must ensure In-Vessel Retention of core materials that may relocate under severe accident conditions in advanced reactors. To reduce cost and simplify manufacture and installation, this new core catcher design consists of several interlocking sections that are machined to fit together when inserted into the lower head. If needed, the core catcher can be manufactured with holes to accommodate lower head penetrations. Each section of the core catcher consists of two material layers with an option to add a third layer (if deemed necessary): a base material, which has the capability to support and contain the mass of core materials that may relocate during a severe accident; an insulating oxide coating material on top of the base material, which resists interactions with high-temperature core materials; and an optional coating on the bottom side of the base material to prevent any potential oxidation of the base material during the lifetime of the reactor. Initial evaluations suggest that a thermally-sprayed oxide material is the most promising candidate insulator coating for a core catcher. Tests suggest that 2 coatings can provide adequate protection to a stainless steel core catcher: -) a 500 {mu}m thick zirconium dioxide coating over a 100-200 {mu}m Inconel 718 bond coating, and -) a 500 {mu}m thick magnesium zirconate coating.

  10. Physician Rating Websites: What Aspects Are Important to Identify a Good Doctor, and Are Patients Capable of Assessing Them? A Mixed-Methods Approach Including Physicians' and Health Care Consumers' Perspectives.

    Science.gov (United States)

    Rothenfluh, Fabia; Schulz, Peter J

    2017-05-01

    Physician rating websites (PRWs) offer health care consumers the opportunity to evaluate their doctor anonymously. However, physicians' professional training and experience create a vast knowledge gap in medical matters between physicians and patients. This raises ethical concerns about the relevance and significance of health care consumers' evaluation of physicians' performance. To identify the aspects physician rating websites should offer for evaluation, this study investigated the aspects of physicians and their practice relevant for identifying a good doctor, and whether health care consumers are capable of evaluating these aspects. In a first step, a Delphi study with physicians from 4 specializations was conducted, testing various indicators to identify a good physician. These indicators were theoretically derived from Donabedian, who classifies quality in health care into pillars of structure, process, and outcome. In a second step, a cross-sectional survey with health care consumers in Switzerland (N=211) was launched based on the indicators developed in the Delphi study. Participants were asked to rate the importance of these indicators to identify a good physician and whether they would feel capable to evaluate those aspects after the first visit to a physician. All indicators were ordered into a 4×4 grid based on evaluation and importance, as judged by the physicians and health care consumers. Agreement between the physicians and health care consumers was calculated applying Holsti's method. In the majority of aspects, physicians and health care consumers agreed on what facets of care were important and not important to identify a good physician and whether patients were able to evaluate them, yielding a level of agreement of 74.3%. The two parties agreed that the infrastructure, staff, organization, and interpersonal skills are both important for a good physician and can be evaluated by health care consumers. Technical skills of a doctor and outcomes

  11. Yeast one-hybrid system used to identify the binding proteins for rat glutathione S-transferase P enhancer I.

    Science.gov (United States)

    Liao, Ming-Xiang; Liu, Dong-Yuan; Zuo, Jin; Fang, Fu-De

    2002-03-01

    To detect the trans-factors specifically binding to the strong enhancer element (GPEI) in the upstream of rat glutathione S-transferase P (GST-P) gene. Yeast one-hybrid system was used to screen rat lung MATCHMAKER cDNA library to identify potential trans-factors that can interact with core sequence of GPEI(cGPEI). Electrophoresis mobility shift assay (EMSA) was used to analyze the binding of transfactors to cGPEI. cDNA fragments coding for the C-terminal part of the transcription factor c-Jun and rat adenine nucleotide translocator (ANT) were isolated. The binding of c-Jun and ANT to GPEI core sequence were confirmed. Rat c-jun transcriptional factor and ANT may interact with cGPEI. They could play an important role in the induced expression of GST-P gene.

  12. Evaluating the effectiveness of a training program that builds teachers' capability to identify and appropriately refer middle and high school students with mental health problems in Brazil: an exploratory study.

    Science.gov (United States)

    Vieira, Marlene A; Gadelha, Ary A; Moriyama, Taís S; Bressan, Rodrigo A; Bordin, Isabel A

    2014-02-28

    In Brazil, like many countries, there has been a failure to identify mental health problems (MHP) in young people and refer them to appropriate care and support. The school environment provides an ideal setting to do this. Therefore, effective programs need to be developed to train teachers to identify and appropriately refer children with possible MHP. We aimed to evaluate teachers' ability to identify and appropriately refer students with possible MHP, and the effectiveness of a psychoeducational strategy to build teachers' capability in this area. To meet the first objective, we conducted a case-control study using a student sample. To meet the second, we employed longitudinal design with repeated measures before and after introducing the psychoeducational strategy using a teacher sample. In the case control study, the Youth Self-Report was used to investigate internalizing and externalizing problems. Before training, teachers selected 26 students who they thought were likely to have MHP. Twenty-six non-selected students acted as controls and were matched by gender, age and grade. The underlying principle was that if teachers could identify abnormal behaviors among their actual students, those with some MHP would likely be among the case group and those without among the control group. In the longitudinal study, 32 teachers were asked to evaluate six vignettes that highlighted behaviors indicating a high risk for psychosis, depression, conduct disorder, hyperactivity, mania, and normal adolescent behavior. We calculated the rates of correct answers for identifying the existence of some MHP and the need for referral before and after training; teachers were not asked to identify the individual conditions. Teachers were already able to identify the most symptomatic students, who had both internalizing and externalizing problems, as possibly having MHP, but teachers had difficulty in identifying students with internalizing problems alone. At least 50.0% of teachers

  13. An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens

    Directory of Open Access Journals (Sweden)

    Nicole Robbins

    2015-11-01

    Full Text Available There is an urgent need to identify new treatments for fungal infections. By combining sub-lethal concentrations of the known antifungals fluconazole, caspofungin, amphotericin B, terbinafine, benomyl, and cyprodinil with ∼3,600 compounds in diverse fungal species, we generated a deep reservoir of chemical-chemical interactions termed the Antifungal Combinations Matrix (ACM. Follow-up susceptibility testing against a fluconazole-resistant isolate of C. albicans unveiled ACM combinations capable of potentiating fluconazole in this clinical strain. We used chemical genetics to elucidate the mode of action of the antimycobacterial drug clofazimine, a compound with unreported antifungal activity that synergized with several antifungals. Clofazimine induces a cell membrane stress for which the Pkc1 signaling pathway is required for tolerance. Additional tests against additional fungal pathogens, including Aspergillus fumigatus, highlighted that clofazimine exhibits efficacy as a combination agent against multiple fungi. Thus, the ACM is a rich reservoir of chemical combinations with therapeutic potential against diverse fungal pathogens.

  14. Identifying Vulnerable Atherosclerotic Plaque in Rabbits Using DMSA-USPIO Enhanced Magnetic Resonance Imaging to Investigate the Effect of Atorvastatin.

    Directory of Open Access Journals (Sweden)

    Chunmei Qi

    Full Text Available Rupture of an atherosclerotic plaque is the primary cause of acute cardiovascular and cerebrovascular syndromes. Early and non-invasive detection of vulnerable atherosclerotic plaques (VP would be significant in preventing some aspects of these syndromes. As a new contrast agent, dimercaptosuccinic acid (DMSA modified ultra-small super paramagnetic iron oxide (USPIO was synthesized and used to identify VP and rupture plaque by magnetic resonance imaging (MRI.Atherosclerosis was induced in male New Zealand White rabbits by feeding a high cholesterol diet (n = 30. Group A with atherosclerosis plaque (n = 10 were controls. VP was established in groups B (n = 10 and C (n = 10 using balloon-induced endothelial injury of the abdominal aorta. Adenovirus-carrying p53 genes were injected into the aortic segments rich in plaques after 8 weeks. Group C was treated with atorvastatin for 8 weeks. Sixteen weeks later, all rabbits underwent pharmacological triggering, and imaging were taken daily for 5 d after DMSA-USPIO infusion. At the first day and before being killed, serum MMP-9, sCD40L, and other lipid indicators were measured.DMSA-USPIO particles accumulated in VP and rupture plaques. Rupture plaques appeared as areas of hyper-intensity on DMSA-USPIO enhanced MRI, especially T2*-weighted sequences, with a signal strength peaking at 96 h. The group given atorvastatin showed few DMSA-USPIO particles and had lower levels of serum indicators. MMP-9 and sCD40L levels in group B were significantly higher than in the other 2 groups (P <0.05.After successfully establishing a VP model in rabbits, DMSA-USPIO was used to enhance MRI for clear identification of plaque inflammation and rupture. Rupture plaques were detectable in this way probably due to an activating inflammatory process. Atorvastatin reduced the inflammatory response and stabilizing VP possibly by decreasing MMP-9 and sCD40L levels.

  15. RAVE J203843.2-002333: The First Highly R-process-enhanced Star Identified in the RAVE Survey

    Science.gov (United States)

    Placco, Vinicius M.; Holmbeck, Erika M.; Frebel, Anna; Beers, Timothy C.; Surman, Rebecca A.; Ji, Alexander P.; Ezzeddine, Rana; Points, Sean D.; Kaleida, Catherine C.; Hansen, Terese T.; Sakari, Charli M.; Casey, Andrew R.

    2017-07-01

    We report the discovery of RAVE J203843.2-002333, a bright (V = 12.73), very metal-poor ([{Fe}/{{H}}] = -2.91), r-process-enhanced ([{Eu}/{Fe}] = +1.64 and [{Ba}/{Eu}] = -0.81) star selected from the RAVE survey. This star was identified as a metal-poor candidate based on its medium-resolution (R ˜ 1600) spectrum obtained with the KPNO/Mayall Telescope, and followed up with high-resolution (R ˜ 66,000) spectroscopy with the Magellan/Clay Telescope, allowing for the determination of elemental abundances for 24 neutron-capture elements, including thorium and uranium. RAVE J2038-0023 is only the fourth metal-poor star with a clearly measured U abundance. The derived chemical abundance pattern exhibits good agreement with those of other known highly r-process-enhanced stars, and evidence suggests that it is not an actinide-boost star. Age estimates were calculated using U/X abundance ratios, yielding a mean age of 13.0 ± 1.1 Gyr. Based on observations gathered with the 6.5 m Magellan Telescopes located at Las Campanas Observatory, Chile; Kitt Peak National Observatory, National Optical Astronomy Observatory (NOAO Prop. ID: 14B-0231; PI: Placco), which is operated by the Association of Universities for Research in Astronomy (AURA) under cooperative agreement with the National Science Foundation. The authors are honored to be permitted to conduct astronomical research on Iolkam Du’ag (Kitt Peak), a mountain with particular significance to the Tohono O’odham.

  16. Facility Interface Capability Assessment (FICA) project report

    International Nuclear Information System (INIS)

    Pope, R.B.; MacDonald, R.R.; Viebrock, J.M.; Mote, N.

    1995-09-01

    The US Department of Energy's (DOE) Office of Civilian Radioactive Waste Management (OCRWM) is responsible for developing the Civilian Radioactive Waste Management System (CRWMS) to accept spent nuclear fuel from commercial facilities. The objective of the Facility Interface Capability Assessment (FICA) project was to assess the capability of each commercial spent nuclear fuel (SNF) storage facility, at which SNF is stored, to handle various SNF shipping casks. The purpose of this report is to present and analyze the results of the facility assessments completed within the FICA project. During Phase 1, the data items required to complete the facility assessments were identified and the database for the project was created. During Phase 2, visits were made to 122 facilities on 76 sites to collect data and information, the database was updated, and assessments of the cask-handling capabilities at each facility were performed. Each assessment of cask-handling capability contains three parts: the current capability of the facility (planning base); the potential enhanced capability if revisions were made to the facility licensing and/or administrative controls; and the potential enhanced capability if limited physical modifications were made to the facility. The main conclusion derived from the planning base assessments is that the current facility capabilities will not allow handling of any of the FICA Casks at 49 of the 122 facilities evaluated. However, consideration of potential revisions and/or modifications showed that all but one of the 49 facilities could be adapted to handle at least one of the FICA Casks. For this to be possible, facility licensing, administrative controls, and/or physical aspects of the facility would need to be modified

  17. Facility Interface Capability Assessment (FICA) project report

    Energy Technology Data Exchange (ETDEWEB)

    Pope, R.B. [ed.] [Oak Ridge National Lab., TN (United States); MacDonald, R.R. [ed.] [Civilian Radioactive Waste Management System, Vienna, VA (United States); Viebrock, J.M.; Mote, N. [Nuclear Assurance Corp., Norcross, GA (United States)

    1995-09-01

    The US Department of Energy`s (DOE) Office of Civilian Radioactive Waste Management (OCRWM) is responsible for developing the Civilian Radioactive Waste Management System (CRWMS) to accept spent nuclear fuel from commercial facilities. The objective of the Facility Interface Capability Assessment (FICA) project was to assess the capability of each commercial spent nuclear fuel (SNF) storage facility, at which SNF is stored, to handle various SNF shipping casks. The purpose of this report is to present and analyze the results of the facility assessments completed within the FICA project. During Phase 1, the data items required to complete the facility assessments were identified and the database for the project was created. During Phase 2, visits were made to 122 facilities on 76 sites to collect data and information, the database was updated, and assessments of the cask-handling capabilities at each facility were performed. Each assessment of cask-handling capability contains three parts: the current capability of the facility (planning base); the potential enhanced capability if revisions were made to the facility licensing and/or administrative controls; and the potential enhanced capability if limited physical modifications were made to the facility. The main conclusion derived from the planning base assessments is that the current facility capabilities will not allow handling of any of the FICA Casks at 49 of the 122 facilities evaluated. However, consideration of potential revisions and/or modifications showed that all but one of the 49 facilities could be adapted to handle at least one of the FICA Casks. For this to be possible, facility licensing, administrative controls, and/or physical aspects of the facility would need to be modified.

  18. Use of a quality improvement tool, the prioritization matrix, to identify and prioritize triage software algorithm enhancement.

    Science.gov (United States)

    North, Frederick; Varkey, Prathiba; Caraballo, Pedro; Vsetecka, Darlene; Bartel, Greg

    2007-10-11

    Complex decision support software can require significant effort in maintenance and enhancement. A quality improvement tool, the prioritization matrix, was successfully used to guide software enhancement of algorithms in a symptom assessment call center.

  19. Enhancing participatory approach in water resources management: development of a survey to evaluate stakeholders needs and priorities related to software capabilities

    Science.gov (United States)

    Foglia, L.; Rossetto, R.; Borsi, I.; Josef, S.; Boukalova, Z.; Triana, F.; Ghetta, M.; Sabbatini, T.; Bonari, E.; Cannata, M.; De Filippis, G.

    2016-12-01

    The EU H2020 FREEWAT project (FREE and open source software tools for WATer resource management) aims at simplifying the application of EU-water related Directives, by developing an open source and public domain, GIS-integrated platform for planning and management of ground- and surface-water resources. The FREEWAT platform is conceived as a canvas, where several distributed and physically-based simulation codes are virtually integrated. The choice of such codes was supported by the result of a survey performed by means of questionnaires distributed to 14 case study FREEWAT project partners and several stakeholders. This was performed in the first phase of the project within the WP 6 (Enhanced science and participatory approach evidence-based decision making), Task 6.1 (Definition of a "needs/tools" evaluation grid). About 30% among all the invited entities and institutions from several EU and non-EU Countries expressed their interest in contributing to the survey. Most of them were research institutions, government and geoenvironmental companies and river basin authorities.The result of the questionnaire provided a spectrum of needs and priorities of partners/stakeholders, which were addressed during the development phase of the FREEWAT platform. The main needs identified were related to ground- and surface-water quality, sustainable water management, interaction between groundwater/surface-water bodies, and design and management of Managed Aquifer Recharge schemes. Needs and priorities were then connected to the specific EU Directives and Regulations to be addressed.One of the main goals of the questionnaires was to collect information and suggestions regarding the use of existing commercial/open-source software tools to address needs and priorities, and regarding the needs to address specific water-related processes/problems.

  20. Enhancing Foreign Consumer Acceptance The Role of Capabilities of Creating Export-Market Oriented Products in Small and Medium-Sized Enterprises (SMEs

    Directory of Open Access Journals (Sweden)

    Firmanzah Firmanzah

    2008-06-01

    Full Text Available The main purpose of this paper is to measure the effects of SMEs capabilities on their export performance. This paper offers a model to test the effects of the capabilities of creating export-market oriented products (EMOPs on increasing SMEs’ export performance. Six hypotheses are developed to analyze causal effects of variables. Using 387 Indonesian SMEs as sample, hypotheses testing highlight the importance of SMEs’ capabilities of building export-market oriented products, which highly follow foreign (export market standards. Hence, these kinds of products increase foreign consumer acceptance. In general, this paper offers a possible explanation to predict the determinants of how SMEs’ can perform in the export market.

  1. Technological Capability's Predictor Variables

    Directory of Open Access Journals (Sweden)

    Fernanda Maciel Reichert

    2011-03-01

    Full Text Available The aim of this study was to identify the factors that influence in configuration of the technological capability of companies in sectors with medium-low technological intensity. To achieve the goal proposed in this article a survey was carried out. Based on the framework developed by Lall (1992 which classifies firms in basic, intermediate and advanced level of technological capability; it was found that the predominant technological capability is intermediate, with 83.7% of respondent companies (plastics companies in Brazil. It is believed that the main contribution of this study is the finding that the dependent variable named “Technological Capability” can be explained at a rate of 65% by six variables: development of new processes; selection of the best equipment supplier; sales of internally developed new technology to third parties; design and manufacture of equipment; study of the work methods and perform inventory control; and improvement of product quality.

  2. Identifying Vulnerable Atherosclerotic Plaque in Rabbits Using DMSA-USPIO Enhanced Magnetic Resonance Imaging to Investigate the Effect of Atorvastatin

    Science.gov (United States)

    Li, Dongye; Wu, Weiheng; Gong, Lei; Li, Yong; Zhang, Qingdui; Zhang, Tao; Zhang, Chao; Zhang, Yu

    2015-01-01

    Background Rupture of an atherosclerotic plaque is the primary cause of acute cardiovascular and cerebrovascular syndromes. Early and non-invasive detection of vulnerable atherosclerotic plaques (VP) would be significant in preventing some aspects of these syndromes. As a new contrast agent, dimercaptosuccinic acid (DMSA) modified ultra-small super paramagnetic iron oxide (USPIO) was synthesized and used to identify VP and rupture plaque by magnetic resonance imaging (MRI). Methods Atherosclerosis was induced in male New Zealand White rabbits by feeding a high cholesterol diet (n = 30). Group A with atherosclerosis plaque (n = 10) were controls. VP was established in groups B (n = 10) and C (n = 10) using balloon-induced endothelial injury of the abdominal aorta. Adenovirus-carrying p53 genes were injected into the aortic segments rich in plaques after 8 weeks. Group C was treated with atorvastatin for 8 weeks. Sixteen weeks later, all rabbits underwent pharmacological triggering, and imaging were taken daily for 5 d after DMSA-USPIO infusion. At the first day and before being killed, serum MMP-9, sCD40L, and other lipid indicators were measured. Results DMSA-USPIO particles accumulated in VP and rupture plaques. Rupture plaques appeared as areas of hyper-intensity on DMSA-USPIO enhanced MRI, especially T2*-weighted sequences, with a signal strength peaking at 96 h. The group given atorvastatin showed few DMSA-USPIO particles and had lower levels of serum indicators. MMP-9 and sCD40L levels in group B were significantly higher than in the other 2 groups (P MRI for clear identification of plaque inflammation and rupture. Rupture plaques were detectable in this way probably due to an activating inflammatory process. Atorvastatin reduced the inflammatory response and stabilizing VP possibly by decreasing MMP-9 and sCD40L levels. PMID:25973795

  3. Research for new UAV capabilities

    Energy Technology Data Exchange (ETDEWEB)

    Canavan, G.H.; Leadabrand, R.

    1996-07-01

    This paper discusses research for new Unmanned Aerial Vehicles (UAV) capabilities. Findings indicate that UAV performance could be greatly enhanced by modest research. Improved sensors and communications enhance near term cost effectiveness. Improved engines, platforms, and stealth improve long term effectiveness.

  4. Structural Capability of an Organization toward Innovation Capability

    DEFF Research Database (Denmark)

    Nielsen, Susanne Balslev; Momeni, Mostafa

    2016-01-01

    The scholars in the field of strategic management have developed two major approaches for attainment of competitive advantage: an approach based on environmental opportunities, and another one based on internal capabilities of an organization. Some investigations in the last two decades have...... indicated that the advantages relying on the internal capabilities of organizations may determine the competitive position of organizations better than environmental opportunities do. Characteristics of firms shows that one of the most internal capabilities that lead the organizations to the strongest...... competitive advantage in the organizations is the innovation capability. The innovation capability is associated with other organizational capabilities, and many organizations have focused on the need to identify innovation capabilities.This research focuses on recognition of the structural aspect...

  5. Uniform Surface Modification of 3D Bioglass®-Based Scaffolds with Mesoporous Silica Particles (MCM-41) for Enhancing Drug Delivery Capability

    Science.gov (United States)

    Boccardi, Elena; Philippart, Anahí; Juhasz-Bortuzzo, Judith A.; Beltrán, Ana M.; Novajra, Giorgia; Vitale-Brovarone, Chiara; Spiecker, Erdmann; Boccaccini, Aldo R.

    2015-01-01

    The design and characterization of a new family of multifunctional scaffolds based on bioactive glass (BG) of 45S5 composition for bone tissue engineering and drug delivery applications are presented. These BG-based scaffolds are developed via a replication method of polyurethane packaging foam. In order to increase the therapeutic functionality, the scaffolds were coated with mesoporous silica particles (MCM-41), which act as an in situ drug delivery system. These sub-micron spheres are characterized by large surface area and pore volume with a narrow pore diameter distribution. The solution used for the synthesis of the silica mesoporous particles was designed to obtain a high-ordered mesoporous structure and spherical shape – both are key factors for achieving the desired controlled drug release. The MCM-41 particles were synthesized directly inside the BG-based scaffolds, and the drug-release capability of this combined system was evaluated. Moreover, the effect of MCM-41 particle coating on the bioactivity of the BG-based scaffolds was assessed. The results indicate that it is possible to obtain a multifunctional scaffold system characterized by high and interconnected porosity, high bioactivity, and sustained drug delivery capability. PMID:26594642

  6. Capitalizing on capabilities.

    Science.gov (United States)

    Ulrich, Dave; Smallwood, Norm

    2004-06-01

    By making the most of organizational capabilities--employees' collective skills and fields of expertise--you can dramatically improve your company's market value. Although there is no magic list of proficiencies that every organization needs in order to succeed, the authors identify 11 intangible assets that well-managed companies tend to have: talent, speed, shared mind-set and coherent brand identity, accountability, collaboration, learning, leadership, customer connectivity, strategic unity, innovation, and efficiency. Such companies typically excel in only three of these capabilities while maintaining industry parity in the other areas. Organizations that fall below the norm in any of the 11 are likely candidates for dysfunction and competitive disadvantage. So you can determine how your company fares in these categories (or others, if the generic list doesn't suit your needs), the authors explain how to conduct a "capabilities audit," describing in particular the experiences and findings of two companies that recently performed such audits. In addition to highlighting which intangible assets are most important given the organization's history and strategy, this exercise will gauge how well your company delivers on its capabilities and will guide you in developing an action plan for improvement. A capabilities audit can work for an entire organization, a business unit, or a region--indeed, for any part of a company that has a strategy to generate financial or customer-related results. It enables executives to assess overall company strengths and weaknesses, senior leaders to define strategy, midlevel managers to execute strategy, and frontline leaders to achieve tactical results. In short, it helps turn intangible assets into concrete strengths.

  7. Decorating TiO2 Nanowires with BaTiO3 Nanoparticles: A New Approach Leading to Substantially Enhanced Energy Storage Capability of High-k Polymer Nanocomposites.

    Science.gov (United States)

    Kang, Da; Wang, Guanyao; Huang, Yanhui; Jiang, Pingkai; Huang, Xingyi

    2018-01-31

    The urgent demand of high energy density and high power density devices has triggered significant interest in high dielectric constant (high-k) flexible nanocomposites comprising dielectric polymer and high-k inorganic nanofiller. However, the large electrical mismatch between polymer and nanofiller usually leads to earlier electric failure of the nanocomposites, resulting in an undesirable decrease of electrical energy storage capability. A few studies show that the introduction of moderate-k shell onto a high-k nanofiller surface can decrease the dielectric constant mismatch, and thus, the corresponding nanocomposites can withstand high electric field. Unfortunately, the low apparent dielectric enhancement of the nanocomposites and high electrical conductivity mismatch between matrix and nanofiller still result in low energy density and low efficiency. In this study, it is demonstrated that encapsulating moderate-k nanofiller with high-k but low electrical conductivity shell is effective to significantly enhance the energy storage capability of dielectric polymer nanocomposites. Specifically, using BaTiO 3 nanoparticles encapsulated TiO 2 (BaTiO 3 @TiO 2 ) core-shell nanowires as filler, the corresponding poly(vinylidene fluoride-co-hexafluoropylene) nanocomposites exhibit superior energy storage capability in comparison with the nanocomposites filled by either BaTiO 3 or TiO 2 nanowires. The nanocomposite film with 5 wt % BaTiO 3 @TiO 2 nanowires possesses an ultrahigh discharged energy density of 9.95 J cm -3 at 500 MV m -1 , much higher than that of commercial biaxial-oriented polypropylene (BOPP) (3.56 J cm -3 at 600 MV m -1 ). This new strategy and corresponding results presented here provide new insights into the design of dielectric polymer nanocomposites with high electrical energy storage capability.

  8. Protein and Molecular Characterization of a Clinically Compliant Amniotic Fluid Stem Cell-Derived Extracellular Vesicle Fraction Capable of Accelerating Muscle Regeneration Through Enhancement of Angiogenesis.

    Science.gov (United States)

    Mellows, Ben; Mitchell, Robert; Antonioli, Manuela; Kretz, Oliver; Chambers, David; Zeuner, Marie-Theres; Denecke, Bernd; Musante, Luca; Ramachandra, Durrgah L; Debacq-Chainiaux, Florence; Holthofer, Harry; Joch, Barbara; Ray, Steve; Widera, Darius; David, Anna L; Huber, Tobias B; Dengjel, Joern; De Coppi, Paolo; Patel, Ketan

    2017-09-15

    The secretome of human amniotic fluid stem cells (AFSCs) has great potential as a therapeutic agent in regenerative medicine. However, it must be produced in a clinically compliant manner before it can be used in humans. In this study, we developed a means of producing a biologically active secretome from AFSCs that is free of all exogenous molecules. We demonstrate that the full secretome is capable of promoting stem cell proliferation, migration, and protection of cells against senescence. Furthermore, it has significant anti-inflammatory properties. Most importantly, we show that it promotes tissue regeneration in a model of muscle damage. We then demonstrate that the secretome contains extracellular vesicles (EVs) that harbor much, but not all, of the biological activity of the whole secretome. Proteomic characterization of the EV and free secretome fraction shows the presence of numerous molecules specific to each fraction that could be key regulators of tissue regeneration. Intriguingly, we show that the EVs only contain miRNA and not mRNA. This suggests that tissue regeneration in the host is mediated by the action of EVs modifying existing, rather than imposing new, signaling pathways. The EVs harbor significant anti-inflammatory activity as well as promote angiogenesis, the latter may be the mechanistic explanation for their ability to promote muscle regeneration after cardiotoxin injury.

  9. Rights, goals, and capabilities

    NARCIS (Netherlands)

    van Hees, M.V.B.P.M

    This article analyses the relationship between rights and capabilities in order to get a better grasp of the kind of consequentialism that the capability theory represents. Capability rights have been defined as rights that have a capability as their object (rights to capabilities). Such a

  10. Combinatorial binding in human and mouse embryonic stem cells identifies conserved enhancers active in early embryonic development.

    Directory of Open Access Journals (Sweden)

    Jonathan Göke

    2011-12-01

    Full Text Available Transcription factors are proteins that regulate gene expression by binding to cis-regulatory sequences such as promoters and enhancers. In embryonic stem (ES cells, binding of the transcription factors OCT4, SOX2 and NANOG is essential to maintain the capacity of the cells to differentiate into any cell type of the developing embryo. It is known that transcription factors interact to regulate gene expression. In this study we show that combinatorial binding is strongly associated with co-localization of the transcriptional co-activator Mediator, H3K27ac and increased expression of nearby genes in embryonic stem cells. We observe that the same loci bound by Oct4, Nanog and Sox2 in ES cells frequently drive expression in early embryonic development. Comparison of mouse and human ES cells shows that less than 5% of individual binding events for OCT4, SOX2 and NANOG are shared between species. In contrast, about 15% of combinatorial binding events and even between 53% and 63% of combinatorial binding events at enhancers active in early development are conserved. Our analysis suggests that the combination of OCT4, SOX2 and NANOG binding is critical for transcription in ES cells and likely plays an important role for embryogenesis by binding at conserved early developmental enhancers. Our data suggests that the fast evolutionary rewiring of regulatory networks mainly affects individual binding events, whereas "gene regulatory hotspots" which are bound by multiple factors and active in multiple tissues throughout early development are under stronger evolutionary constraints.

  11. Dissecting the functional role of key residues in triheme cytochrome PpcA: a path to rational design of G. sulfurreducens strains with enhanced electron transfer capabilities.

    Directory of Open Access Journals (Sweden)

    Leonor Morgado

    Full Text Available PpcA is the most abundant member of a family of five triheme cytochromes c7 in the bacterium Geobacter sulfurreducens (Gs and is the most likely carrier of electrons destined for outer surface during respiration on solid metal oxides, a process that requires extracellular electron transfer. This cytochrome has the highest content of lysine residues (24% among the family, and it was suggested to be involved in e-/H(+ energy transduction processes. In the present work, we investigated the functional role of lysine residues strategically located in the vicinity of each heme group. Each lysine was replaced by glutamine or glutamic acid to evaluate the effects of a neutral or negatively charged residue in each position. The results showed that replacing Lys9 (located near heme IV, Lys18 (near heme I or Lys22 (between hemes I and III has essentially no effect on the redox properties of the heme groups and are probably involved in redox partner recognition. On the other hand, Lys43 (near heme IV, Lys52 (between hemes III and IV and Lys60 (near heme III are crucial in the regulation of the functional mechanism of PpcA, namely in the selection of microstates that allow the protein to establish preferential e-/H(+ transfer pathways. The results showed that the preferred e-/H(+ transfer pathways are only established when heme III is the last heme to oxidize, a feature reinforced by a higher difference between its reduction potential and that of its predecessor in the order of oxidation. We also showed that K43 and K52 mutants keep the mechanistic features of PpcA by establishing preferential e-/H+ transfer pathways at lower reduction potential values than the wild-type protein, a property that can enable rational design of Gs strains with optimized extracellular electron transfer capabilities.

  12. Laboratory microfusion capability study

    International Nuclear Information System (INIS)

    1993-05-01

    The purpose of this study is to elucidate the issues involved in developing a Laboratory Microfusion Capability (LMC) which is the major objective of the Inertial Confinement Fusion (ICF) program within the purview of the Department of Energy's Defense Programs. The study was initiated to support a number of DOE management needs: to provide insight for the evolution of the ICF program; to afford guidance to the ICF laboratories in planning their research and development programs; to inform Congress and others of the details and implications of the LMC; to identify criteria for selection of a concept for the Laboratory Microfusion Facility and to develop a coordinated plan for the realization of an LMC. As originally proposed, the LMC study was divided into two phases. The first phase identifies the purpose and potential utility of the LMC, the regime of its performance parameters, driver independent design issues and requirements, its development goals and requirements, and associated technical, management, staffing, environmental, and other developmental and operational issues. The second phase addresses driver-dependent issues such as specific design, range of performance capabilities, and cost. The study includes four driver options; the neodymium-glass solid state laser, the krypton fluoride excimer gas laser, the light-ion accelerator, and the heavy-ion induction linear accelerator. The results of the Phase II study are described in the present report

  13. Mobile Test Capabilities

    Data.gov (United States)

    Federal Laboratory Consortium — The Electrical Power Mobile Test capabilities are utilized to conduct electrical power quality testing on aircraft and helicopters. This capability allows that the...

  14. Enhanced production of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) copolymer and antimicrobial yellow pigmentation from Cupriavidus sp. USMAHM13 with antibiofilm capability.

    Science.gov (United States)

    Ismail, Iszatty; Gurusamy, Tana Poorani; Ramachandran, Hema; Al-Ashraf Amirul, Abdullah

    2017-04-21

    Antibiofilm polymers have the ability to inhibit bacterial biofilm formation, which is known to occur ubiquitously in the environment and pose risks of infection. In this study, production of P(3HB-co-4HB) copolymer and antimicrobial yellow pigment from Cupriavidus sp. USMAHM13 are enhanced through medium optimization. Before the improvement of yellow pigment production, screening for the best additional supplement was performed resulting in high-yield yellow pigmentation using yeast extract with optimum concentration of 2 g/L. Effects of different concentrations of 1,4-butanediol, ammonium acetate, and yeast extract were studied using central composite design. Under optimal conditions, 53 wt% of polyhydroxyalkanoate (PHA) content, 0.35 g/L of pigment concentration, and 5.87 g/L of residual biomass were achieved at 0.56 wt% C of 1,4-butanediol, 1.14 g/L of ammonium acetate, and 2 g/L of yeast extract. Antibiofilm tests revealed that the yellow pigment coated on P(3HB-co-4HB) copolymer had significant effect on the inhibition of bacteria proliferation and colonization from 6 hr onward reaching 100% inhibition by 12 hr, hence effectively inhibiting the biofilm formation.

  15. Application of lithiated perfluorosulfonate ionomer binders to enhance high rate capability in LiMn2O4 cathodes for lithium ion batteries

    International Nuclear Information System (INIS)

    Chiu, Kuo-Feng; Su, Shih Hsuan; Leu, Hoang-Juh; Chen, Yi Shiang

    2014-01-01

    Lithiated perfluorosulfonate ionomer has been used as the binder for LiMn 2 O 4 cathodes. Casted membranes of the lithiated ionomer exhibit ionic conductivity of 1.4 × 10 −4 S/cm. Composite cathodes composed of LiMn 2 O 4 , carbon black and the ionomer binder have been fabricated. All components of the cathodes are well bound and dispersed as characterized by scanning electron microscope and energy dispersive spectroscope. The cathodes using the conventional poly-vinylidene fluoride binder have also been prepared for comparison. Under high rate (5 C-20 C) and high temperature (60 °C) operation, the LiMn 2 O 4 cathodes with the ionomer binder exhibit higher capacity and improved cycling stability. As indicated by the electrochemical impedance spectra, the ionomer binder forms ion-conducting interface layers on the LiMn 2 O 4 particles and results in lower interface resistance. It enables the cells utilizing the ionomer binder to achieve higher capacity and enhanced cycling stability even under harsh conditions

  16. Overexpression of Three Glucosinolate Biosynthesis Genes in Brassica napus Identifies Enhanced Resistance to Sclerotinia sclerotiorum and Botrytis cinerea.

    Directory of Open Access Journals (Sweden)

    Yuanyuan Zhang

    Full Text Available Sclerotinia sclerotiorum and Botrytis cinerea are notorious plant pathogenic fungi with an extensive host range including Brassica crops. Glucosinolates (GSLs are an important group of secondary metabolites characteristic of the Brassicales order, whose degradation products are proving to be increasingly important in plant protection. Enhancing the defense effect of GSL and their associated degradation products is an attractive strategy to strengthen the resistance of plants by transgenic approaches. We generated the lines of Brassica napus with three biosynthesis genes involved in GSL metabolic pathway (BnMAM1, BnCYP83A1 and BnUGT74B1, respectively. We then measured the foliar GSLs of each transgenic lines and inoculated them with S. sclerotiorum and B. cinerea. Compared with the wild type control, over-expressing BnUGT74B1 in B. napus increased the aliphatic and indolic GSL levels by 1.7 and 1.5 folds in leaves respectively; while over-expressing BnMAM1 or BnCYP83A1 resulted in an approximate 1.5-fold higher only in the aliphatic GSL level in leaves. The results of plant inoculation demonstrated that BnUGT74B1-overexpressing lines showed less severe disease symptoms and tissue damage compared with the wild type control, but BnMAM1 or BnCYP83A1-overexpressing lines showed no significant difference in comparison to the controls. These results suggest that the resistance to S. sclerotiorum and B. cinerea in B. napus could be enhanced through tailoring the GSL profiles by transgenic approaches or molecular breeding, which provides useful information to assist plant breeders to design improved breeding strategies.

  17. Improved fermentative L-cysteine overproduction by enhancing a newly identified thiosulfate assimilation pathway in Escherichia coli.

    Science.gov (United States)

    Kawano, Yusuke; Onishi, Fumito; Shiroyama, Maeka; Miura, Masashi; Tanaka, Naoyuki; Oshiro, Satoshi; Nonaka, Gen; Nakanishi, Tsuyoshi; Ohtsu, Iwao

    2017-09-01

    Sulfate (SO 4 2- ) is an often-utilized and well-understood inorganic sulfur source in microorganism culture. Recently, another inorganic sulfur source, thiosulfate (S 2 O 3 2- ), was proposed to be more advantageous in microbial growth and biotechnological applications. Although its assimilation pathway is known to depend on O-acetyl-L-serine sulfhydrylase B (CysM in Escherichia coli), its metabolism has not been extensively investigated. Therefore, we aimed to explore another yet-unidentified CysM-independent thiosulfate assimilation pathway in E. coli. ΔcysM cells could accumulate essential L-cysteine from thiosulfate as the sole sulfur source and could grow, albeit slowly, demonstrating that a CysM-independent thiosulfate assimilation pathway is present in E. coli. This pathway is expected to consist of the initial part of the thiosulfate to sulfite (SO 3 2- ) conversion, and the latter part might be shared with the final part of the known sulfate assimilation pathway [sulfite → sulfide (S 2- ) → L-cysteine]. This is because thiosulfate-grown ΔcysM cells could accumulate a level of sulfite and sulfide equivalent to that of wild-type cells. The catalysis of thiosulfate to sulfite is at least partly mediated by thiosulfate sulfurtransferase (GlpE), because its overexpression could enhance cellular thiosulfate sulfurtransferase activity in vitro and complement the slow-growth phenotype of thiosulfate-grown ΔcysM cells in vivo. GlpE is therefore concluded to function in the novel CysM-independent thiosulfate assimilation pathway by catalyzing thiosulfate to sulfite. We applied this insight to L-cysteine overproduction in E. coli and succeeded in enhancing it by GlpE overexpression in media containing glucose or glycerol as the main carbon source, by up to ~1.7-fold (1207 mg/l) or ~1.5-fold (1529 mg/l), respectively.

  18. Identifying factors which enhance capacity to engage in clinical education among podiatry practitioners: an action research project.

    Science.gov (United States)

    Abey, Sally; Lea, Susan; Callaghan, Lynne; Shaw, Steve; Cotton, Debbie

    2015-01-01

    Health profession students develop practical skills whilst integrating theory with practice in a real world environment as an important component of their training. Research in the area of practice placements has identified challenges and barriers to the delivery of effective placement learning. However, there has been little research in podiatry and the question of which factors impact upon clinical educators' capacity to engage with the role remains an under-researched area. This paper presents the second phase of an action research project designed to determine the factors that impact upon clinical educators' capacity to engage with the mentorship role. An online survey was developed and podiatry clinical educators recruited through National Health Service (NHS) Trusts. The survey included socio-demographic items, and questions relating to the factors identified as possible variables influencing clinical educator capacity; the latter was assessed using the 'Clinical Educator Capacity to Engage' scale (CECE). Descriptive statistics were used to explore demographic data whilst the relationship between the CECE and socio-demographic factors were examined using inferential statistics in relation to academic profile, career profile and organisation of the placement. The survey response rate was 42 % (n = 66). Multiple linear regression identified four independent variables which explain a significant proportion of the variability of the dependent variable, 'capacity to engage with clinical education', with an adjusted R2 of 0.428. The four variables were: protected mentorship time, clinical educator relationship with university, sign-off responsibility, and volunteer status. The identification of factors that impact upon clinical educators' capacity to engage in mentoring of students has relevance for strategic planning and policy-making with the emphasis upon capacity-building at an individual level, so that the key attitudes and characteristics that are linked

  19. Heart rate biofeedback fails to enhance children's ability to identify time spent in moderate to vigorous physical activity.

    Science.gov (United States)

    Conley, Marguerite M; Gastin, Paul B; Brown, Helen; Shaw, Christine

    2011-03-01

    Physical activity recommendations for children in several countries advise that all young people should accumulate at least 60 min of moderate to vigorous physical activity every day. Perceiving physical activity intensity, however, can be a difficult task for children and it is not clear whether children can identify their levels of moderate to vigorous physical activity in accordance with the recommended guidelines. This study aimed to (1) explore whether children can identify time spent in moderate to vigorous physical activity; and (2) investigate whether heart rate biofeedback would improve children's ability to estimate time spent in moderate to vigorous physical activity. Thirty seven children (15 boys and 22 girls, mean age 12.6 years) wore data recording Polar E600 heart rate monitors during eight physical education lessons. At the end of each lesson children's estimated time in zone was compared to their actual time in zone. During a six lesson Intervention phase, one class was assigned to a biofeedback group whilst the other class acted as the control group and received no heart rate biofeedback. Post-Intervention, students in the biofeedback group were no better than the control group at estimating time spent in zone (mean relative error of estimation biofeedback group: Pre-Intervention 41±32% to Post-Intervention 28±26%; control group: Pre-Intervention 40±39% to Post-Intervention 31±37%). Thus it seems that identifying time spent in moderate to vigorous physical activity remains a complex task for children aged 11-13 even with the help of heart rate biofeedback. Copyright © 2010 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

  20. Capabilities for Strategic Adaptation

    DEFF Research Database (Denmark)

    Distel, Andreas Philipp

    This dissertation explores capabilities that enable firms to strategically adapt to environmental changes and preserve competitiveness over time – often referred to as dynamic capabilities. While dynamic capabilities being a popular research domain, too little is known about what these capabiliti...

  1. Enhanced Recovery After Surgery as an auditing framework for identifying improvements to perioperative nutrition care of older surgical patients.

    Science.gov (United States)

    Byrnes, Angela; Banks, Merrilyn; Mudge, Alison; Young, Adrienne; Bauer, Judy

    2018-06-01

    Older patients are at increased risk of malnutrition and reduced physical function. Using Enhanced Recovery After Surgery (ERAS) guidelines as an auditing framework, this study aimed to determine adherence of nutrition care to perioperative best practice in older patients. A single researcher retrieved data via chart review. Seventy-five consenting patients ≥65 years (median 72 (range 65-95) years, 61% male) admitted postoperatively to general surgical wards were recruited. Sixty per cent had a primary diagnosis of cancer and 51% underwent colorectal resection. Seventeen per cent and 4% of patients met fasting targets of 2-4 h for fluid and 6-8 h for food, respectively. Fifty-five per cent were upgraded to full diet by first postoperative day. Nil received preoperative carbohydrate loading. Minimally invasive surgery (p = 0.01) and no anastomosis formation (p = 0.05) were associated with receiving ERAS-concordant nutrition care. This study highlights areas for improvement in perioperative nutrition care of older patients at our facility.

  2. Comparative genomic analysis identified a mutation related to enhanced heterologous protein production in the filamentous fungus Aspergillus oryzae.

    Science.gov (United States)

    Jin, Feng-Jie; Katayama, Takuya; Maruyama, Jun-Ichi; Kitamoto, Katsuhiko

    2016-11-01

    Genomic mapping of mutations using next-generation sequencing technologies has facilitated the identification of genes contributing to fundamental biological processes, including human diseases. However, few studies have used this approach to identify mutations contributing to heterologous protein production in industrial strains of filamentous fungi, such as Aspergillus oryzae. In a screening of A. oryzae strains that hyper-produce human lysozyme (HLY), we previously isolated an AUT1 mutant that showed higher production of various heterologous proteins; however, the underlying factors contributing to the increased heterologous protein production remained unclear. Here, using a comparative genomic approach performed with whole-genome sequences, we attempted to identify the genes responsible for the high-level production of heterologous proteins in the AUT1 mutant. The comparative sequence analysis led to the detection of a gene (AO090120000003), designated autA, which was predicted to encode an unknown cytoplasmic protein containing an alpha/beta-hydrolase fold domain. Mutation or deletion of autA was associated with higher production levels of HLY. Specifically, the HLY yields of the autA mutant and deletion strains were twofold higher than that of the control strain during the early stages of cultivation. Taken together, these results indicate that combining classical mutagenesis approaches with comparative genomic analysis facilitates the identification of novel genes involved in heterologous protein production in filamentous fungi.

  3. The ultra-sensitive Nodewalk technique identifies stochastic from virtual, population-based enhancer hubs regulating MYC in 3D: Implications for the fitness of cancer cells

    KAUST Repository

    Sumida, Noriyuki

    2018-03-27

    The relationship between stochastic transcriptional bursts and dynamic 3D chromatin states is not well understood due to poor sensitivity and/or resolution of current chromatin structure-based assays. Consequently, it is not well established if enhancers operate individually and/or in clusters to coordinate gene transcription. In the current study, we introduce Nodewalk, which uniquely combines high sensitivity with high resolution to enable the analysis of chromatin networks in minute input material. The >10,000-fold increase in sensitivity over other many-to-all competing methods uncovered that active chromatin hubs identified in large input material, corresponding to 10 000 cells, flanking the MYC locus are primarily virtual. Thus, the close agreement between chromatin interactomes generated from aliquots corresponding to less than 10 cells with randomly re-sampled interactomes, we find that numerous distal enhancers positioned within flanking topologically associating domains (TADs) converge on MYC in largely mutually exclusive manners. Moreover, when comparing with several enhancer baits, the assignment of the MYC locus as the node with the highest dynamic importance index, indicates that it is MYC targeting its enhancers, rather than vice versa. Dynamic changes in the configuration of the boundary between TADs flanking MYC underlie numerous stochastic encounters with a diverse set of enhancers to depict the plasticity of its transcriptional regulation. Such an arrangement might increase the fitness of the cancer cell by increasing the probability of MYC transcription in response to a wide range of environmental cues encountered by the cell during the neoplastic process.

  4. The ultra-sensitive Nodewalk technique identifies stochastic from virtual, population-based enhancer hubs regulating MYC in 3D: Implications for the fitness of cancer cells

    KAUST Repository

    Sumida, Noriyuki; Sifakis, Emmanouil; Scholz, Barbara A; Fernandez Woodbridge, Alejandro; Kiani, Narsis A.; Gomez-Cabrero, David; Svensson, J Peter; Tegner, Jesper; Gondor, Anita; Ohlsson, Rolf

    2018-01-01

    The relationship between stochastic transcriptional bursts and dynamic 3D chromatin states is not well understood due to poor sensitivity and/or resolution of current chromatin structure-based assays. Consequently, it is not well established if enhancers operate individually and/or in clusters to coordinate gene transcription. In the current study, we introduce Nodewalk, which uniquely combines high sensitivity with high resolution to enable the analysis of chromatin networks in minute input material. The >10,000-fold increase in sensitivity over other many-to-all competing methods uncovered that active chromatin hubs identified in large input material, corresponding to 10 000 cells, flanking the MYC locus are primarily virtual. Thus, the close agreement between chromatin interactomes generated from aliquots corresponding to less than 10 cells with randomly re-sampled interactomes, we find that numerous distal enhancers positioned within flanking topologically associating domains (TADs) converge on MYC in largely mutually exclusive manners. Moreover, when comparing with several enhancer baits, the assignment of the MYC locus as the node with the highest dynamic importance index, indicates that it is MYC targeting its enhancers, rather than vice versa. Dynamic changes in the configuration of the boundary between TADs flanking MYC underlie numerous stochastic encounters with a diverse set of enhancers to depict the plasticity of its transcriptional regulation. Such an arrangement might increase the fitness of the cancer cell by increasing the probability of MYC transcription in response to a wide range of environmental cues encountered by the cell during the neoplastic process.

  5. A business analytics capability framework

    Directory of Open Access Journals (Sweden)

    Ranko Cosic

    2015-09-01

    Full Text Available Business analytics (BA capabilities can potentially provide value and lead to better organisational performance. This paper develops a holistic, theoretically-grounded and practically relevant business analytics capability framework (BACF that specifies, defines and ranks the capabilities that constitute an organisational BA initiative. The BACF was developed in two phases. First, an a priori conceptual framework was developed based on the Resource-Based View theory of the firm and a thematic content analysis of the BA literature. Second, the conceptual framework was further developed and refined using a three round Delphi study involving 16 BA experts. Changes from the Delphi study resulted in a refined and confirmed framework including detailed capability definitions, together with a ranking of the capabilities based on importance. The BACF will help academic researchers and industry practitioners to better understand the capabilities that constitute an organisational BA initiative and their relative importance. In future work, the capabilities in the BACF will be operationalised to measure their as-is status, thus enabling organisations to identify key areas of strength and weakness and prioritise future capability improvement efforts.

  6. Genome wide analysis of inbred mouse lines identifies a locus containing Ppar-gamma as contributing to enhanced malaria survival.

    Directory of Open Access Journals (Sweden)

    Selina E R Bopp

    2010-05-01

    Full Text Available The genetic background of a patient determines in part if a person develops a mild form of malaria and recovers, or develops a severe form and dies. We have used a mouse model to detect genes involved in the resistance or susceptibility to Plasmodium berghei malaria infection. To this end we first characterized 32 different mouse strains infected with P. berghei and identified survival as the best trait to discriminate between the strains. We found a locus on chromosome 6 by linking the survival phenotypes of the mouse strains to their genetic variations using genome wide analyses such as haplotype associated mapping and the efficient mixed-model for association. This new locus involved in malaria resistance contains only two genes and confirms the importance of Ppar-gamma in malaria infection.

  7. Dynamic capabilities, Marketing Capability and Organizational Performance

    Directory of Open Access Journals (Sweden)

    Adriana Roseli Wünsch Takahashi

    2017-01-01

    Full Text Available The goal of the study is to investigate the influence of dynamic capabilities on organizational performance and the role of marketing capabilities as a mediator in this relationship in the context of private HEIs in Brazil. As a research method we carried out a survey with 316 IES and data analysis was operationalized with the technique of structural equation modeling. The results indicate that the dynamic capabilities have influence on organizational performance only when mediated by marketing ability. The marketing capability has an important role in the survival, growth and renewal on educational services offerings for HEIs in private sector, and consequently in organizational performance. It is also demonstrated that mediated relationship is more intense for HEI with up to 3,000 students and other organizational profile variables such as amount of courses, the constitution, the type of institution and type of education do not significantly alter the results.

  8. Indeterminate solid hepatic lesions identified on non-diagnostic contrast-enhanced computed tomography: Assessment of the additional diagnostic value of contrast-enhanced ultrasound in the non-cirrhotic liver

    International Nuclear Information System (INIS)

    Quaia, Emilio; De Paoli, Luca; Angileri, Roberta; Cabibbo, Biagio; Cova, Maria Assunta

    2014-01-01

    Objective: To assess the additional diagnostic value of contrast-enhanced ultrasound (CEUS) in the characterization of indeterminate solid hepatic lesions identified on non-diagnostic contrast-enhanced computed tomography (CT). Methods: Fifty-five solid hepatic lesions (1–4 cm in diameter) in 46 non-cirrhotic patients (26 female, 20 male; age ± SD, 55 ± 10 years) underwent CEUS after being detected on contrast-enhanced CT which was considered as non-diagnostic after on-site analysis. Two blinded independent readers assessed CT and CEUS scans and were asked to classify retrospectively each lesion as a malignant or benign based on reference diagnostic criteria for the different hepatic lesion histotypes. Diagnostic accuracy and confidence (area – A z – under ROC curve) were assessed by using gadobenate dimeglumine-enhanced magnetic resonance (MR) imaging (n = 30 lesions), histology (n = 7 lesions), or US follow-up (n = 18 lesions) as the reference standards. Results: Final diagnoses included 29 hemangiomas, 3 focal nodular hyperplasias, 1 hepatocellular adenoma, and 22 metastases. The additional review of CEUS after CT images improved significantly (P < .05) the diagnostic accuracy (before vs after CEUS review = 49% [20/55] vs 89% [49/55] – reader 1 and 43% [24/55] vs 92% [51/55] – reader 2) and confidence (A z , 95% Confidence Intervals before vs after CEUS review = .773 [.652–.895] vs .997 [.987–1] – reader 1 and .831 [.724–.938] vs .998 [.992–1] – reader 2). Conclusions: CEUS improved the characterization of indeterminate solid hepatic lesions identified on non-diagnostic contrast-enhanced CT by identifying some specific contrast enhancement patterns.

  9. Bioinformatic analysis of neurotropic HIV envelope sequences identifies polymorphisms in the gp120 bridging sheet that increase macrophage-tropism through enhanced interactions with CCR5

    International Nuclear Information System (INIS)

    Mefford, Megan E.; Kunstman, Kevin; Wolinsky, Steven M.; Gabuzda, Dana

    2015-01-01

    Macrophages express low levels of the CD4 receptor compared to T-cells. Macrophage-tropic HIV strains replicating in brain of untreated patients with HIV-associated dementia (HAD) express Envs that are adapted to overcome this restriction through mechanisms that are poorly understood. Here, bioinformatic analysis of env sequence datasets together with functional studies identified polymorphisms in the β3 strand of the HIV gp120 bridging sheet that increase M-tropism. D197, which results in loss of an N-glycan located near the HIV Env trimer apex, was detected in brain in some HAD patients, while position 200 was estimated to be under positive selection. D197 and T/V200 increased fusion and infection of cells expressing low CD4 by enhancing gp120 binding to CCR5. These results identify polymorphisms in the HIV gp120 bridging sheet that overcome the restriction to macrophage infection imposed by low CD4 through enhanced gp120–CCR5 interactions, thereby promoting infection of brain and other macrophage-rich tissues. - Highlights: • We analyze HIV Env sequences and identify amino acids in beta 3 of the gp120 bridging sheet that enhance macrophage tropism. • These amino acids at positions 197 and 200 are present in brain of some patients with HIV-associated dementia. • D197 results in loss of a glycan near the HIV Env trimer apex, which may increase exposure of V3. • These variants may promote infection of macrophages in the brain by enhancing gp120–CCR5 interactions

  10. Bioinformatic analysis of neurotropic HIV envelope sequences identifies polymorphisms in the gp120 bridging sheet that increase macrophage-tropism through enhanced interactions with CCR5

    Energy Technology Data Exchange (ETDEWEB)

    Mefford, Megan E., E-mail: megan_mefford@hms.harvard.edu [Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA (United States); Kunstman, Kevin, E-mail: kunstman@northwestern.edu [Northwestern University Medical School, Chicago, IL (United States); Wolinsky, Steven M., E-mail: s-wolinsky@northwestern.edu [Northwestern University Medical School, Chicago, IL (United States); Gabuzda, Dana, E-mail: dana_gabuzda@dfci.harvard.edu [Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA (United States); Department of Neurology (Microbiology and Immunobiology), Harvard Medical School, Boston, MA (United States)

    2015-07-15

    Macrophages express low levels of the CD4 receptor compared to T-cells. Macrophage-tropic HIV strains replicating in brain of untreated patients with HIV-associated dementia (HAD) express Envs that are adapted to overcome this restriction through mechanisms that are poorly understood. Here, bioinformatic analysis of env sequence datasets together with functional studies identified polymorphisms in the β3 strand of the HIV gp120 bridging sheet that increase M-tropism. D197, which results in loss of an N-glycan located near the HIV Env trimer apex, was detected in brain in some HAD patients, while position 200 was estimated to be under positive selection. D197 and T/V200 increased fusion and infection of cells expressing low CD4 by enhancing gp120 binding to CCR5. These results identify polymorphisms in the HIV gp120 bridging sheet that overcome the restriction to macrophage infection imposed by low CD4 through enhanced gp120–CCR5 interactions, thereby promoting infection of brain and other macrophage-rich tissues. - Highlights: • We analyze HIV Env sequences and identify amino acids in beta 3 of the gp120 bridging sheet that enhance macrophage tropism. • These amino acids at positions 197 and 200 are present in brain of some patients with HIV-associated dementia. • D197 results in loss of a glycan near the HIV Env trimer apex, which may increase exposure of V3. • These variants may promote infection of macrophages in the brain by enhancing gp120–CCR5 interactions.

  11. Collaborative Capability in Coworking Spaces: Convenience Sharing or Community Building?

    Directory of Open Access Journals (Sweden)

    Marcelo F. Castilho

    2017-12-01

    Full Text Available This study explores the development of collaborative capability in coworking spaces. It is based on the perception of collaboration among 31 coworking founders, community managers, and coworkers of those spaces. In-depth interviews around the meaning of collaboration and its challenges were conducted in 14 coworking spaces located in six Asian countries. A set of factors was identified and a model was proposed based on a set of four dimensions: enabling knowledge sharing, enhancing a creative field, enhancing an individual action for the collective, and supporting a collective action to an effective execution. The “Convenience Sharing” and “Community Building” coworking types based on Capdevila (2014 suggest different conditions under which collaborative capability develops. Convenience Sharing coworking spaces tend to foster collaborative capability through knowledge sharing and effective execution, whereas Community Building coworking spaces tend to foster collaborative capability by enhancing a creative field and individual action for the collective. Overall, this study contributes to a theoretical model for coworking spaces to help coworking founders and community managers make strategic decisions. The findings suggest that collaborative capability in coworking spaces depends on the interlacing of a set of factors along four dimensions that relate in varying degrees of intensity to a two-fold coworking space typology.

  12. Development of students learning capabilities and professional capabilities

    DEFF Research Database (Denmark)

    Ringtved, Ulla Lunde; Wahl, Christian; Belle, Gianna

    This paper describes the work-in-progress on a project that aims todevelop a tool that via learning analytic methods enable studentsto enhance, document and assess the development of their learningcapabilities and professional capabilities in consequence of theirself-initiated study activities...... during their bachelor educations. Thetool aims at enhancing the development of students’ capabilities toself-initiate, self-regulate and self-assess their study activities.The tool uses the concept of collective intelligence as source formotivation and inspiration in self-initiating study activities...... as wellas self-assessing them. The tool is based on a heutagogical approachto support reflection on learning potential in these activities. Thisenhances the educational use of students self-initiated learningactivities by bringing visibility and evidence to them, and therebybringing value to the assessment...

  13. Capabilities of Future Training Support Packages

    National Research Council Canada - National Science Library

    Burnside, Billy

    2004-01-01

    .... This report identifies and analyzes five key capabilities needed in future TSPs: rapid tailoring or modification, reach, simulated operating environment, performance measurement, and pretests/selection criteria...

  14. SOLE: enhanced FIA data analysis capabilities

    Science.gov (United States)

    Michael Spinney; Paul Van Deusen

    2009-01-01

    The Southern On Line Estimator (SOLE), is an Internet-based annual forest inventory and analysis (FIA) data analysis tool developed cooperatively by the National Council for Air and Stream Improvement and the Forest Service, U.S. Department of Agriculture's Forest Inventory and Analysis program at the Southern Research Station. Recent development of SOLE has...

  15. Enhancing Peacekeeping Capabilities in West Africa

    National Research Council Canada - National Science Library

    Sagna, Insa

    2005-01-01

    ... (Economic Community Monitoring Group) exists and the fact that African Union (AU) supports ECOMOG's effort signify the realization of a dream shared by leaders that Africans should take greater initiative in the resolution of their own problems...

  16. Using Servers to Enhance Control System Capability

    International Nuclear Information System (INIS)

    Bickley, M.; Bowling, B. A.; Bryan, D. A.; Zeijts, J. van; White, K. S.; Witherspoon, S.

    1999-01-01

    Many traditional control systems include a distributed collection of front end machines to control hardware. Backend tools are used to view, modify, and record the signals generated by these front end machines. Software servers, which are a middleware layer between the front and back ends, can improve a control system in several ways. Servers can enable on-line processing of raw data, and consolidation of functionality. It many cases data retrieved from the front end must be processed in order to convert the raw data into useful information. These calculations are often redundantly performance by different programs, frequently offline. Servers can monitor the raw data and rapidly perform calculations, producing new signals which can be treated like any other control system signal, and can be used by any back end application. Algorithms can be incorporated to actively modify signal values in the control system based upon changes of other signals, essentially producing feedback in a control system. Servers thus increase the flexibility of a control system. Lastly, servers running on inexpensive UNIXworkstations can relay or cache frequently needed information, reducing the load on front end hardware by functioning as concentrators. Rather than many back end tools connecting directly to the front end machines, increasing the work load of these machines, they instead connect to the server. Servers like those discussed above have been used successfully at the Thomas Jefferson National Accelerator Facility to provide functionality such as beam steering, fault monitoring, storage of machine parameters, and on-line data processing. The authors discuss the potential uses of such servers, and share the results of work performed to date

  17. Upgrading of TREAT experimental capabilities

    International Nuclear Information System (INIS)

    Dickerman, C.E.; Rose, D.; Bhattacharyya, S.K.

    1982-01-01

    The TREAT facility at the Argonne National Laboratory site in the Idaho National Engineering Laboratory is being upgraded to provide capabilities for fast-reactor-safety transient experiments not possible at any other experimental facility. Principal TREAT Upgrade (TU) goal is provision for 37-pin size experiments on energetics of core-disruptive accidents (CDA) in fast breeder reactor cores with moderate sodium void coefficients. this goal requires a significant enhancement of the capabilities of the TREAT facility, specifically including reactor control, hardened neutron spectrum incident on the test sample, and enlarged building. The upgraded facility will retain the capability for small-size experiments of the types currently being performed in TREAT. Reactor building and crane upgrading have been completed. TU schedules call for the components of the upgraded reactor system to be finished in 1984, including upgraded TREAT fuel and control system, and expanded coverage by the hodoscope fuel-motion diagnostics system

  18. Microfoundations of Routines and Capabilities

    DEFF Research Database (Denmark)

    Felin, Teppo; Foss, Nicolai Juul; Heimriks, Koen H.

    We discuss the microfoundations of routines and capabilities, including why a microfoundations view is needed and how it may inform work on organizational and competitive heterogeneity. Building on extant research, we identify three primary categories of micro-level components underlying routines...

  19. Microfoundations of Routines and Capabilities

    DEFF Research Database (Denmark)

    Felin, Tippo; Foss, Nicolai Juul; Heimericks, Koen H.

    2012-01-01

    This article introduces the Special Issue and discusses the microfoundations of routines and capabilities, including why a microfoundations view is needed and how it may inform work on organizational and competitive heterogeneity. Building on extant research, we identify three primary categories ...

  20. An in vivo cis-regulatory screen at the type 2 diabetes associated TCF7L2 locus identifies multiple tissue-specific enhancers.

    Directory of Open Access Journals (Sweden)

    Daniel Savic

    Full Text Available Genome-wide association studies (GWAS have repeatedly shown an association between non-coding variants in the TCF7L2 locus and risk for type 2 diabetes (T2D, implicating a role for cis-regulatory variation within this locus in disease etiology. Supporting this hypothesis, we previously localized complex regulatory activity to the TCF7L2 T2D-associated interval using an in vivo bacterial artificial chromosome (BAC enhancer-trapping reporter strategy. To follow-up on this broad initial survey of the TCF7L2 regulatory landscape, we performed a fine-mapping enhancer scan using in vivo mouse transgenic reporter assays. We functionally interrogated approximately 50% of the sequences within the T2D-associated interval, utilizing sequence conservation within this 92-kb interval to determine the regulatory potential of all evolutionary conserved sequences that exhibited conservation to the non-eutherian mammal opossum. Included in this study was a detailed functional interrogation of sequences spanning both protective and risk alleles of single nucleotide polymorphism (SNP rs7903146, which has exhibited allele-specific enhancer function in pancreatic beta cells. Using these assays, we identified nine segments regulating various aspects of the TCF7L2 expression profile and that constitute nearly 70% of the sequences tested. These results highlight the regulatory complexity of this interval and support the notion that a TCF7L2 cis-regulatory disruption leads to T2D predisposition.

  1. The Health Informatics Trial Enhancement Project (HITE: Using routinely collected primary care data to identify potential participants for a depression trial

    Directory of Open Access Journals (Sweden)

    Lyons Ronan A

    2010-04-01

    Full Text Available Abstract Background Recruitment to clinical trials can be challenging. We identified anonymous potential participants to an existing pragmatic randomised controlled depression trial to assess the feasibility of using routinely collected data to identify potential trial participants. We discuss the strengths and limitations of this approach, assess its potential value, report challenges and ethical issues encountered. Methods Swansea University's Health Information Research Unit's Secure Anonymised Information Linkage (SAIL database of routinely collected health records was interrogated, using Structured Query Language (SQL. Read codes were used to create an algorithm of inclusion/exclusion criteria with which to identify suitable anonymous participants. Two independent clinicians rated the eligibility of the potential participants' identified. Inter-rater reliability was assessed using the kappa statistic and inter-class correlation. Results The study population (N = 37263 comprised all adults registered at five general practices in Swansea UK. Using the algorithm 867 anonymous potential participants were identified. The sensitivity and specificity results > 0.9 suggested a high degree of accuracy from the algorithm. The inter-rater reliability results indicated strong agreement between the confirming raters. The Intra Class Correlation Coefficient (Cronbach's Alpha > 0.9, suggested excellent agreement and Kappa coefficient > 0.8; almost perfect agreement. Conclusions This proof of concept study showed that routinely collected primary care data can be used to identify potential participants for a pragmatic randomised controlled trial of folate augmentation of antidepressant therapy for the treatment of depression. Further work will be needed to assess generalisability to other conditions and settings and the inclusion of this approach to support Electronic Enhanced Recruitment (EER.

  2. Building Service Provider Capabilities

    DEFF Research Database (Denmark)

    Brandl, Kristin; Jaura, Manya; Ørberg Jensen, Peter D.

    2015-01-01

    In this paper we study whether and how the interaction between clients and the service providers contributes to the development of capabilities in service provider firms. In situations where such a contribution occurs, we analyze how different types of activities in the production process...... process. We find that clients influence the development of human capital capabilities and management capabilities in reciprocally produced services. While in sequential produced services clients influence the development of organizational capital capabilities and management capital capabilities....... of the services, such as sequential or reciprocal task activities, influence the development of different types of capabilities. We study five cases of offshore-outsourced knowledge-intensive business services that are distinguished according to their reciprocal or sequential task activities in their production...

  3. Space Communications Capability Roadmap Interim Review

    Science.gov (United States)

    Spearing, Robert; Regan, Michael

    2005-01-01

    Contents include the following: Identify the need for a robust communications and navigation architecture for the success of exploration and science missions. Describe an approach for specifying architecture alternatives and analyzing them. Establish a top level architecture based on a network of networks. Identify key enabling technologies. Synthesize capability, architecture and technology into an initial capability roadmap.

  4. An in-depth characterization of the major psoriasis susceptibility locus identifies candidate susceptibility alleles within an HLA-C enhancer element.

    Directory of Open Access Journals (Sweden)

    Alex Clop

    Full Text Available Psoriasis is an immune-mediated skin disorder that is inherited as a complex genetic trait. Although genome-wide association scans (GWAS have identified 36 disease susceptibility regions, more than 50% of the genetic variance can be attributed to a single Major Histocompatibility Complex (MHC locus, known as PSORS1. Genetic studies indicate that HLA-C is the strongest PSORS1 candidate gene, since markers tagging HLA-Cw*0602 consistently generate the most significant association signals in GWAS. However, it is unclear whether HLA-Cw*0602 is itself the causal PSORS1 allele, especially as the role of SNPs that may affect its expression has not been investigated. Here, we have undertaken an in-depth molecular characterization of the PSORS1 interval, with a view to identifying regulatory variants that may contribute to disease susceptibility. By analysing high-density SNP data, we refined PSORS1 to a 179 kb region encompassing HLA-C and the neighbouring HCG27 pseudogene. We compared multiple MHC sequences spanning this refined locus and identified 144 candidate susceptibility variants, which are unique to chromosomes bearing HLA-Cw*0602. In parallel, we investigated the epigenetic profile of the critical PSORS1 interval and uncovered three enhancer elements likely to be active in T lymphocytes. Finally we showed that nine candidate susceptibility SNPs map within a HLA-C enhancer and that three of these variants co-localise with binding sites for immune-related transcription factors. These data indicate that SNPs affecting HLA-Cw*0602 expression are likely to contribute to psoriasis susceptibility and highlight the importance of integrating multiple experimental approaches in the investigation of complex genomic regions such as the MHC.

  5. Enhanced

    Directory of Open Access Journals (Sweden)

    Martin I. Bayala

    2014-06-01

    Full Text Available Land Surface Temperature (LST is a key parameter in the energy balance model. However, the spatial resolution of the retrieved LST from sensors with high temporal resolution is not accurate enough to be used in local-scale studies. To explore the LST–Normalised Difference Vegetation Index relationship potential and obtain thermal images with high spatial resolution, six enhanced image sharpening techniques were assessed: the disaggregation procedure for radiometric surface temperatures (TsHARP, the Dry Edge Quadratic Function, the Difference of Edges (Ts∗DL and three models supported by the relationship of surface temperature and water stress of vegetation (Normalised Difference Water Index, Normalised Difference Infrared Index and Soil wetness index. Energy Balance Station data and in situ measurements were used to validate the enhanced LST images over a mixed agricultural landscape in the sub-humid Pampean Region of Argentina (PRA, during 2006–2010. Landsat Thematic Mapper (TM and Moderate Resolution Imaging Spectroradiometer (EOS-MODIS thermal datasets were assessed for different spatial resolutions (e.g., 960, 720 and 240 m and the performances were compared with global and local TsHARP procedures. Results suggest that the Ts∗DL technique is the most adequate for simulating LST to high spatial resolution over the heterogeneous landscape of a sub-humid region, showing an average root mean square error of less than 1 K.

  6. Distinctive Dynamic Capabilities for New Business Creation

    DEFF Research Database (Denmark)

    Rosenø, Axel; Enkel, Ellen; Mezger, Florian

    2013-01-01

    This study examines the distinctive dynamic capabilities for new business creation in established companies. We argue that these are very different from those for managing incremental innovation within a company's core business. We also propose that such capabilities are needed in both slow...... and fast-paced industries, and that similarities exist across industries. Hence, the study contributes to dynamic capabilities literature by: 1) identifying the distinctive dynamic capabilities for new business creation; 2) shifting focus away from dynamic capabilities in environments characterised by high...... clock-speed and uncertainty towards considering dynamic capabilities for the purpose of developing new businesses, which also implies a high degree of uncertainty. Based on interviews with 33 companies, we identify distinctive dynamic capabilities for new business creation, find that dynamic...

  7. Capability Handbook- offline metrology

    DEFF Research Database (Denmark)

    Islam, Aminul; Marhöfer, David Maximilian; Tosello, Guido

    This offline metrological capability handbook has been made in relation to HiMicro Task 3.3. The purpose of this document is to assess the metrological capability of the HiMicro partners and to gather the information of all available metrological instruments in the one single document. It provides...

  8. Dynamic Capabilities and Performance

    DEFF Research Database (Denmark)

    Wilden, Ralf; Gudergan, Siegfried P.; Nielsen, Bo Bernhard

    2013-01-01

    are contingent on the competitive intensity faced by firms. Our findings demonstrate the performance effects of internal alignment between organizational structure and dynamic capabilities, as well as the external fit of dynamic capabilities with competitive intensity. We outline the advantages of PLS...

  9. Telematics Options and Capabilities

    Energy Technology Data Exchange (ETDEWEB)

    Hodge, Cabell [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2017-09-05

    This presentation describes the data tracking and analytical capabilities of telematics devices. Federal fleet managers can use the systems to keep their drivers safe, maintain a fuel efficient fleet, ease their reporting burden, and save money. The presentation includes an example of how much these capabilities can save fleets.

  10. Applying the Theoretical Domains Framework to identify barriers and targeted interventions to enhance nurses' use of electronic medication management systems in two Australian hospitals.

    Science.gov (United States)

    Debono, Deborah; Taylor, Natalie; Lipworth, Wendy; Greenfield, David; Travaglia, Joanne; Black, Deborah; Braithwaite, Jeffrey

    2017-03-27

    Medication errors harm hospitalised patients and increase health care costs. Electronic Medication Management Systems (EMMS) have been shown to reduce medication errors. However, nurses do not always use EMMS as intended, largely because implementation of such patient safety strategies requires clinicians to change their existing practices, routines and behaviour. This study uses the Theoretical Domains Framework (TDF) to identify barriers and targeted interventions to enhance nurses' appropriate use of EMMS in two Australian hospitals. This qualitative study draws on in-depth interviews with 19 acute care nurses who used EMMS. A convenience sampling approach was used. Nurses working on the study units (N = 6) in two hospitals were invited to participate if available during the data collection period. Interviews inductively explored nurses' experiences of using EMMS (step 1). Data were analysed using the TDF to identify theory-derived barriers to nurses' appropriate use of EMMS (step 2). Relevant behaviour change techniques (BCTs) were identified to overcome key barriers to using EMMS (step 3) followed by the identification of potential literature-informed targeted intervention strategies to operationalise the identified BCTs (step 4). Barriers to nurses' use of EMMS in acute care were represented by nine domains of the TDF. Two closely linked domains emerged as major barriers to EMMS use: Environmental Context and Resources (availability and properties of computers on wheels (COWs); technology characteristics; specific contexts; competing demands and time pressure) and Social/Professional Role and Identity (conflict between using EMMS appropriately and executing behaviours critical to nurses' professional role and identity). The study identified three potential BCTs to address the Environmental Context and Resources domain barrier: adding objects to the environment; restructuring the physical environment; and prompts and cues. Seven BCTs to address Social

  11. Accelerator and Electrodynamics Capability Review

    International Nuclear Information System (INIS)

    Jones, Kevin W.

    2010-01-01

    Los Alamos National Laboratory (LANL) uses capability reviews to assess the science, technology and engineering (STE) quality and institutional integration and to advise Laboratory Management on the current and future health of the STE. Capability reviews address the STE integration that LANL uses to meet mission requirements. The Capability Review Committees serve a dual role of providing assessment of the Laboratory's technical contributions and integration towards its missions and providing advice to Laboratory Management. The assessments and advice are documented in reports prepared by the Capability Review Committees that are delivered to the Director and to the Principal Associate Director for Science, Technology and Engineering (PADSTE). Laboratory Management will use this report for STE assessment and planning. LANL has defined fifteen STE capabilities. Electrodynamics and Accelerators is one of the seven STE capabilities that LANL Management (Director, PADSTE, technical Associate Directors) has identified for review in Fiscal Year (FY) 2010. Accelerators and electrodynamics at LANL comprise a blend of large-scale facilities and innovative small-scale research with a growing focus on national security applications. This review is organized into five topical areas: (1) Free Electron Lasers; (2) Linear Accelerator Science and Technology; (3) Advanced Electromagnetics; (4) Next Generation Accelerator Concepts; and (5) National Security Accelerator Applications. The focus is on innovative technology with an emphasis on applications relevant to Laboratory mission. The role of Laboratory Directed Research and Development (LDRD) in support of accelerators/electrodynamics will be discussed. The review provides an opportunity for interaction with early career staff. Program sponsors and customers will provide their input on the value of the accelerator and electrodynamics capability to the Laboratory mission.

  12. Accelerator and electrodynamics capability review

    Energy Technology Data Exchange (ETDEWEB)

    Jones, Kevin W [Los Alamos National Laboratory

    2010-01-01

    Los Alamos National Laboratory (LANL) uses capability reviews to assess the science, technology and engineering (STE) quality and institutional integration and to advise Laboratory Management on the current and future health of the STE. Capability reviews address the STE integration that LANL uses to meet mission requirements. The Capability Review Committees serve a dual role of providing assessment of the Laboratory's technical contributions and integration towards its missions and providing advice to Laboratory Management. The assessments and advice are documented in reports prepared by the Capability Review Committees that are delivered to the Director and to the Principal Associate Director for Science, Technology and Engineering (PADSTE). Laboratory Management will use this report for STE assessment and planning. LANL has defined fifteen STE capabilities. Electrodynamics and Accelerators is one of the seven STE capabilities that LANL Management (Director, PADSTE, technical Associate Directors) has identified for review in Fiscal Year (FY) 2010. Accelerators and electrodynamics at LANL comprise a blend of large-scale facilities and innovative small-scale research with a growing focus on national security applications. This review is organized into five topical areas: (1) Free Electron Lasers; (2) Linear Accelerator Science and Technology; (3) Advanced Electromagnetics; (4) Next Generation Accelerator Concepts; and (5) National Security Accelerator Applications. The focus is on innovative technology with an emphasis on applications relevant to Laboratory mission. The role of Laboratory Directed Research and Development (LDRD) in support of accelerators/electrodynamics will be discussed. The review provides an opportunity for interaction with early career staff. Program sponsors and customers will provide their input on the value of the accelerator and electrodynamics capability to the Laboratory mission.

  13. Electronic Power Transformer Control Strategy in Wind Energy Conversion Systems for Low Voltage Ride-through Capability Enhancement of Directly Driven Wind Turbines with Permanent Magnet Synchronous Generators (D-PMSGs

    Directory of Open Access Journals (Sweden)

    Hui Huang

    2014-11-01

    Full Text Available This paper investigates the use of an Electronic Power Transformer (EPT incorporated with an energy storage system to smooth the wind power fluctuations and enhance the low voltage ride-through (LVRT capability of directly driven wind turbines with permanent magnet synchronous generators (D-PMSGs. The decoupled control schemes of the system, including the grid side converter control scheme, generator side converter control scheme and the control scheme of the energy storage system, are presented in detail. Under normal operating conditions, the energy storage system absorbs the high frequency component of the D-PMSG output power to smooth the wind power fluctuations. Under grid fault conditions, the energy storage system absorbs the redundant power, which could not be transferred to the grid by the EPT, to help the D-PMSG to ride through low voltage conditions. This coordinated control strategy is validated by simulation studies using MATLAB/Simulink. With the proposed control strategy, the output wind power quality is improved and the D-PMSG can ride through severe grid fault conditions.

  14. Dynamic capabilities and innovation capabilities: The case of the ‘Innovation Clinic’

    Directory of Open Access Journals (Sweden)

    Fred Strønen

    2017-01-01

    Full Text Available In this explorative study, we investigate the relationship between dynamic capabilities and innovation capabilities. Dynamic capabilities are at the core of strategic management in terms of how firms can ensure adaptation to changing environments over time. Our paper follows two paths of argumentation. First, we review and discuss some major contributions to the theories on ordinary capabilities, dynamic capabilities, and innovation capabilities. We seek to identify different understandings of the concepts in question, in order to clarify the distinctions and relationships between dynamic capabilities and innovation capabilities. Second, we present a case study of the ’Innovation Clinic’ at a major university hospital, including four innovation projects. We use this case study to explore and discuss how dynamic capabilities can be extended, as well as to what extent innovation capabilities can be said to be dynamic. In our conclusion, we discuss the conditions for nurturing ‘dynamic innovation capabilities’ in organizations.

  15. Human-Centered Design Capability

    Science.gov (United States)

    Fitts, David J.; Howard, Robert

    2009-01-01

    For NASA, human-centered design (HCD) seeks opportunities to mitigate the challenges of living and working in space in order to enhance human productivity and well-being. Direct design participation during the development stage is difficult, however, during project formulation, a HCD approach can lead to better more cost-effective products. HCD can also help a program enter the development stage with a clear vision for product acquisition. HCD tools for clarifying design intent are listed. To infuse HCD into the spaceflight lifecycle the Space and Life Sciences Directorate developed the Habitability Design Center. The Center has collaborated successfully with program and project design teams and with JSC's Engineering Directorate. This presentation discusses HCD capabilities and depicts the Center's design examples and capabilities.

  16. LOFT Augmented Operator Capability Program

    International Nuclear Information System (INIS)

    Hollenbeck, D.A.; Krantz, E.A.; Hunt, G.L.; Meyer, O.R.

    1980-01-01

    The outline of the LOFT Augmented Operator Capability Program is presented. This program utilizes the LOFT (Loss-of-Fluid Test) reactor facility which is located at the Idaho National Engineering Laboratory and the LOFT operational transient experiment series as a test bed for methods of enhancing the reactor operator's capability for safer operation. The design of an Operational Diagnotics and Display System is presented which was backfit to the existing data acquisition computers. Basic color-graphic displays of the process schematic and trend type are presented. In addition, displays were developed and are presented which represent safety state vector information. A task analysis method was applied to LOFT reactor operating procedures to test its usefulness in defining the operator's information needs and workload

  17. FMEF/experimental capabilities

    International Nuclear Information System (INIS)

    Burgess, C.A.; Dronen, V.R.

    1981-01-01

    The Fuels and Materials Examination Facility (FMEF), under construction at the Hanford site north of Richland, Washington, will be one of the most modern facilities offering irradiated fuels and materials examination capabilities and fuel fabrication development technologies. Scheduled for completion in 1984, the FMEF will provide examination capability for fuel assemblies, fuel pins and test pins irradiated in the FFTF. Various functions of the FMEF are described, with emphasis on experimental data-gathering capabilities in the facility's Nondestructive and Destructive examination cell complex

  18. KSC Technical Capabilities Website

    Science.gov (United States)

    Nufer, Brian; Bursian, Henry; Brown, Laurette L.

    2010-01-01

    This document is the website pages that review the technical capabilities that the Kennedy Space Center (KSC) has for partnership opportunities. The purpose of this information is to make prospective customers aware of the capabilities and provide an opportunity to form relationships with the experts at KSC. The technical capabilities fall into these areas: (1) Ground Operations and Processing Services, (2) Design and Analysis Solutions, (3) Command and Control Systems / Services, (4) Materials and Processes, (5) Research and Technology Development and (6) Laboratories, Shops and Test Facilities.

  19. Resources, constraints and capabilities

    NARCIS (Netherlands)

    Dhondt, S.; Oeij, P.R.A.; Schröder, A.

    2018-01-01

    Human and financial resources as well as organisational capabilities are needed to overcome the manifold constraints social innovators are facing. To unlock the potential of social innovation for the whole society new (social) innovation friendly environments and new governance structures

  20. a Capability approach

    African Journals Online (AJOL)

    efforts towards gender equality in education as a means of achieving social justice. ... should mean that a lot of capability approach-oriented commentators are ... processes, their forms of exercising power, and their rules, unwritten cultures, ...

  1. Engineering Capabilities and Partnerships

    Science.gov (United States)

    Poulos, Steve

    2010-01-01

    This slide presentation reviews the engineering capabilities at Johnson Space Center, The presentation also reviews the partnerships that have resulted in successfully designed and developed projects that involved commercial and educational institutions.

  2. Brandishing Cyberattack Capabilities

    Science.gov (United States)

    2013-01-01

    Advertising cyberwar capabilities may be helpful. It may back up a deterrence strategy. It might dissuade other states from conventional mischief or...to enable the attack.5 Many of the instruments of the attack remain with the target system, nestled in its log files, or even in the malware itself...debat- able. Even if demonstrated, what worked yesterday may not work today. But difficult does not mean impossible. Advertising cyberwar capabilities

  3. CASL Dakota Capabilities Summary

    Energy Technology Data Exchange (ETDEWEB)

    Adams, Brian M. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Simmons, Chris [Univ. of Texas, Austin, TX (United States); Williams, Brian J. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-10-10

    The Dakota software project serves the mission of Sandia National Laboratories and supports a worldwide user community by delivering state-of-the-art research and robust, usable software for optimization and uncertainty quantification. These capabilities enable advanced exploration and riskinformed prediction with a wide range of computational science and engineering models. Dakota is the verification and validation (V&V) / uncertainty quantification (UQ) software delivery vehicle for CASL, allowing analysts across focus areas to apply these capabilities to myriad nuclear engineering analyses.

  4. Dynamic capabilities and network benefits

    Directory of Open Access Journals (Sweden)

    Helge Svare

    2017-01-01

    Full Text Available The number of publicly funded initiatives to establish or strengthen networks and clusters, in order to enhance innovation, has been increasing. Returns on such investments vary, and the aim of this study is to explore to what extent the variation in benefits for firms participating in networks or clusters can be explained by their dynamic capabilities (DC. Based on survey data from five Norwegian networks, the results suggest that firms with higher DC are more successful in harvesting the potential benefits of being member of a network.

  5. Conceptual Model of IT Infrastructure Capability and Its Empirical Justification

    Institute of Scientific and Technical Information of China (English)

    QI Xianfeng; LAN Boxiong; GUO Zhenwei

    2008-01-01

    Increasing importance has been attached to the value of information technology (IT) infrastructure in today's organizations. The development of efficacious IT infrastructure capability enhances business performance and brings sustainable competitive advantage. This study analyzed the IT infrastructure capability in a holistic way and then presented a concept model of IT capability. IT infrastructure capability was categorized into sharing capability, service capability, and flexibility. This study then empirically tested the model using a set of survey data collected from 145 firms. Three factors emerge from the factor analysis as IT flexibility, IT service capability, and IT sharing capability, which agree with those in the conceptual model built in this study.

  6. Intratumor partitioning and texture analysis of dynamic contrast-enhanced (DCE)-MRI identifies relevant tumor subregions to predict pathological response of breast cancer to neoadjuvant chemotherapy.

    Science.gov (United States)

    Wu, Jia; Gong, Guanghua; Cui, Yi; Li, Ruijiang

    2016-11-01

    To predict pathological response of breast cancer to neoadjuvant chemotherapy (NAC) based on quantitative, multiregion analysis of dynamic contrast enhancement magnetic resonance imaging (DCE-MRI). In this Institutional Review Board-approved study, 35 patients diagnosed with stage II/III breast cancer were retrospectively investigated using 3T DCE-MR images acquired before and after the first cycle of NAC. First, principal component analysis (PCA) was used to reduce the dimensionality of the DCE-MRI data with high temporal resolution. We then partitioned the whole tumor into multiple subregions using k-means clustering based on the PCA-defined eigenmaps. Within each tumor subregion, we extracted four quantitative Haralick texture features based on the gray-level co-occurrence matrix (GLCM). The change in texture features in each tumor subregion between pre- and during-NAC was used to predict pathological complete response after NAC. Three tumor subregions were identified through clustering, each with distinct enhancement characteristics. In univariate analysis, all imaging predictors except one extracted from the tumor subregion associated with fast washout were statistically significant (P < 0.05) after correcting for multiple testing, with area under the receiver operating characteristic (ROC) curve (AUC) or AUCs between 0.75 and 0.80. In multivariate analysis, the proposed imaging predictors achieved an AUC of 0.79 (P = 0.002) in leave-one-out cross-validation. This improved upon conventional imaging predictors such as tumor volume (AUC = 0.53) and texture features based on whole-tumor analysis (AUC = 0.65). The heterogeneity of the tumor subregion associated with fast washout on DCE-MRI predicted pathological response to NAC in breast cancer. J. Magn. Reson. Imaging 2016;44:1107-1115. © 2016 International Society for Magnetic Resonance in Medicine.

  7. Space Logistics: Launch Capabilities

    Science.gov (United States)

    Furnas, Randall B.

    1989-01-01

    The current maximum launch capability for the United States are shown. The predicted Earth-to-orbit requirements for the United States are presented. Contrasting the two indicates the strong National need for a major increase in Earth-to-orbit lift capability. Approximate weights for planned payloads are shown. NASA is studying the following options to meet the need for a new heavy-lift capability by mid to late 1990's: (1) Shuttle-C for near term (include growth versions); and (2) the Advanced Lauching System (ALS) for the long term. The current baseline two-engine Shuttle-C has a 15 x 82 ft payload bay and an expected lift capability of 82,000 lb to Low Earth Orbit. Several options are being considered which have expanded diameter payload bays. A three-engine Shuttle-C with an expected lift of 145,000 lb to LEO is being evaluated as well. The Advanced Launch System (ALS) is a potential joint development between the Air Force and NASA. This program is focused toward long-term launch requirements, specifically beyond the year 2000. The basic approach is to develop a family of vehicles with the same high reliability as the Shuttle system, yet offering a much greater lift capability at a greatly reduced cost (per pound of payload). The ALS unmanned family of vehicles will provide a low end lift capability equivalent to Titan IV, and a high end lift capability greater than the Soviet Energia if requirements for such a high-end vehicle are defined.In conclusion, the planning of the next generation space telescope should not be constrained to the current launch vehicles. New vehicle designs will be driven by the needs of anticipated heavy users.

  8. Understanding dynamic capabilities through knowledge management

    DEFF Research Database (Denmark)

    Nielsen, Anders Paarup

    2006-01-01

    In the paper eight knowledge management activities are identified; knowledge creation, acquisition, capture, assembly, sharing, integration, leverage and exploitation. These activities are assembled into the three dynamic capabilities of knowledge development, knowledge (re......)combination and knowledge use. The dynamic capabilities and the associated knowledge management activities create flows to and from the firm’s stock of knowledge and they support the creation and use of organizational capabilities....

  9. The new MCNP6 depletion capability

    International Nuclear Information System (INIS)

    Fensin, M. L.; James, M. R.; Hendricks, J. S.; Goorley, J. T.

    2012-01-01

    The first MCNP based in-line Monte Carlo depletion capability was officially released from the Radiation Safety Information and Computational Center as MCNPX 2.6.0. Both the MCNP5 and MCNPX codes have historically provided a successful combinatorial geometry based, continuous energy, Monte Carlo radiation transport solution for advanced reactor modeling and simulation. However, due to separate development pathways, useful simulation capabilities were dispersed between both codes and not unified in a single technology. MCNP6, the next evolution in the MCNP suite of codes, now combines the capability of both simulation tools, as well as providing new advanced technology, in a single radiation transport code. We describe here the new capabilities of the MCNP6 depletion code dating from the official RSICC release MCNPX 2.6.0, reported previously, to the now current state of MCNP6. NEA/OECD benchmark results are also reported. The MCNP6 depletion capability enhancements beyond MCNPX 2.6.0 reported here include: (1) new performance enhancing parallel architecture that implements both shared and distributed memory constructs; (2) enhanced memory management that maximizes calculation fidelity; and (3) improved burnup physics for better nuclide prediction. MCNP6 depletion enables complete, relatively easy-to-use depletion calculations in a single Monte Carlo code. The enhancements described here help provide a powerful capability as well as dictate a path forward for future development to improve the usefulness of the technology. (authors)

  10. The New MCNP6 Depletion Capability

    International Nuclear Information System (INIS)

    Fensin, Michael Lorne; James, Michael R.; Hendricks, John S.; Goorley, John T.

    2012-01-01

    The first MCNP based inline Monte Carlo depletion capability was officially released from the Radiation Safety Information and Computational Center as MCNPX 2.6.0. Both the MCNP5 and MCNPX codes have historically provided a successful combinatorial geometry based, continuous energy, Monte Carlo radiation transport solution for advanced reactor modeling and simulation. However, due to separate development pathways, useful simulation capabilities were dispersed between both codes and not unified in a single technology. MCNP6, the next evolution in the MCNP suite of codes, now combines the capability of both simulation tools, as well as providing new advanced technology, in a single radiation transport code. We describe here the new capabilities of the MCNP6 depletion code dating from the official RSICC release MCNPX 2.6.0, reported previously, to the now current state of MCNP6. NEA/OECD benchmark results are also reported. The MCNP6 depletion capability enhancements beyond MCNPX 2.6.0 reported here include: (1) new performance enhancing parallel architecture that implements both shared and distributed memory constructs; (2) enhanced memory management that maximizes calculation fidelity; and (3) improved burnup physics for better nuclide prediction. MCNP6 depletion enables complete, relatively easy-to-use depletion calculations in a single Monte Carlo code. The enhancements described here help provide a powerful capability as well as dictate a path forward for future development to improve the usefulness of the technology.

  11. Dynamic contrast-enhanced perfusion area-detector CT assessed with various mathematical models: Its capability for therapeutic outcome prediction for non-small cell lung cancer patients with chemoradiotherapy as compared with that of FDG-PET/CT

    Energy Technology Data Exchange (ETDEWEB)

    Ohno, Yoshiharu, E-mail: yosirad@kobe-u.ac.jp [Division of Functional and Diagnostic Imaging Research, Department of Radiology, Kobe University Graduate School of Medicine, Kobe (Japan); Advanced Biomedical Imaging Research Center, Kobe University Graduate School of Medicine, Kobe (Japan); Fujisawa, Yasuko [Toshiba Medical Systems Corporation, Otawara (Japan); Koyama, Hisanobu; Kishida, Yuji; Seki, Shinichiro [Division of Radiology, Department of Radiology, Kobe University Graduate School of Medicine, Kobe (Japan); Sugihara, Naoki [Toshiba Medical Systems Corporation, Otawara (Japan); Yoshikawa, Takeshi [Division of Functional and Diagnostic Imaging Research, Department of Radiology, Kobe University Graduate School of Medicine, Kobe (Japan); Advanced Biomedical Imaging Research Center, Kobe University Graduate School of Medicine, Kobe (Japan)

    2017-01-15

    Purpose: To directly compare the capability of dynamic first-pass contrast-enhanced (CE-) perfusion area-detector CT (ADCT) and PET/CT for early prediction of treatment response, disease progression and overall survival of non-small cell carcinoma (NSCLC) patients treated with chemoradiotherapy. Materials and methods: Fifty-three consecutive Stage IIIB NSCLC patients who had undergone PET/CT, dynamic first-pass CE-perfusion ADCT, chemoradiotherapy, and follow-up examination were enrolled in this study. They were divided into two groups: 1) complete or partial response (CR + PR) and 2) stable or progressive disease (SD + PD). Pulmonary arterial and systemic arterial perfusions and total perfusion were assessed at targeted lesions with the dual-input maximum slope method, permeability surface and distribution volume with the Patlak plot method, tumor perfusion with the single-input maximum slope method, and SUV{sub max}, and results were averaged to determine final values for each patient. Next, step-wise regression analysis was used to determine which indices were the most useful for predicting therapeutic effect. Finally, overall survival of responders and non-responders assessed by using the indices that had a significant effect on prediction of therapeutic outcome was statistically compared. Results: The step-wise regression test showed that therapeutic effect (r{sup 2} = 0.63, p = 0.01) was significantly affected by the following three factors in order of magnitude of impact: systemic arterial perfusion, total perfusion, and SUV{sub max}. Mean overall survival showed a significant difference for total perfusion (p = 0.003) and systemic arterial perfusion (p = 0.04). Conclusion: Dynamic first-pass CE-perfusion ADCT as well as PET/CT are useful for treatment response prediction in NSCLC patients treated with chemoradiotherapy.

  12. Dynamic contrast-enhanced perfusion area-detector CT assessed with various mathematical models: Its capability for therapeutic outcome prediction for non-small cell lung cancer patients with chemoradiotherapy as compared with that of FDG-PET/CT

    International Nuclear Information System (INIS)

    Ohno, Yoshiharu; Fujisawa, Yasuko; Koyama, Hisanobu; Kishida, Yuji; Seki, Shinichiro; Sugihara, Naoki; Yoshikawa, Takeshi

    2017-01-01

    Purpose: To directly compare the capability of dynamic first-pass contrast-enhanced (CE-) perfusion area-detector CT (ADCT) and PET/CT for early prediction of treatment response, disease progression and overall survival of non-small cell carcinoma (NSCLC) patients treated with chemoradiotherapy. Materials and methods: Fifty-three consecutive Stage IIIB NSCLC patients who had undergone PET/CT, dynamic first-pass CE-perfusion ADCT, chemoradiotherapy, and follow-up examination were enrolled in this study. They were divided into two groups: 1) complete or partial response (CR + PR) and 2) stable or progressive disease (SD + PD). Pulmonary arterial and systemic arterial perfusions and total perfusion were assessed at targeted lesions with the dual-input maximum slope method, permeability surface and distribution volume with the Patlak plot method, tumor perfusion with the single-input maximum slope method, and SUV max , and results were averaged to determine final values for each patient. Next, step-wise regression analysis was used to determine which indices were the most useful for predicting therapeutic effect. Finally, overall survival of responders and non-responders assessed by using the indices that had a significant effect on prediction of therapeutic outcome was statistically compared. Results: The step-wise regression test showed that therapeutic effect (r 2 = 0.63, p = 0.01) was significantly affected by the following three factors in order of magnitude of impact: systemic arterial perfusion, total perfusion, and SUV max . Mean overall survival showed a significant difference for total perfusion (p = 0.003) and systemic arterial perfusion (p = 0.04). Conclusion: Dynamic first-pass CE-perfusion ADCT as well as PET/CT are useful for treatment response prediction in NSCLC patients treated with chemoradiotherapy.

  13. Synthesis of Superparamagnetic Core-Shell Structure Supported Pd Nanocatalysts for Catalytic Nitrite Reduction with Enhanced Activity, No Detection of Undesirable Product of Ammonium, and Easy Magnetic Separation Capability.

    Science.gov (United States)

    Sun, Wuzhu; Yang, Weiyi; Xu, Zhengchao; Li, Qi; Shang, Jian Ku

    2016-01-27

    Superparamagnetic nanocatalysts could minimize both the external and internal mass transport limitations and neutralize OH(-) produced in the reaction more effectively to enhance the catalytic nitrite reduction efficiency with the depressed product selectivity to undesirable ammonium, while possess an easy magnetic separation capability. However, commonly used qusi-monodispersed superparamagnetic Fe3O4 nanosphere is not suitable as catalyst support for nitrite reduction because it could reduce the catalytic reaction efficiency and the product selectivity to N2, and the iron leakage could bring secondary contamination to the treated water. In this study, protective shells of SiO2, polymethylacrylic acid, and carbon were introduced to synthesize Fe3O4@SiO2/Pd, Fe3O4@PMAA/Pd, and Fe3O4@C/Pd catalysts for catalytic nitrite reduction. It was found that SiO2 shell could provide the complete protection to Fe3O4 nanosphere core among these shells. Because of its good dispersion, dense structure, and complete protection to Fe3O4, the Fe3O4@SiO2/Pd catalyst demonstrated the highest catalytic nitrite reduction activity without the detection of NH4(+) produced. Due to this unique structure, the activity of Fe3O4@SiO2/Pd catalysts for nitrite reduction was found to be independent of the Pd nanoparticle size or shape, and their product selectivity was independent of the Pd nanoparticle size, shape, and content. Furthermore, their superparamagnetic nature and high saturation magnetization allowed their easy magnetic separation from treated water, and they also demonstrated a good stability during the subsequent recycling experiment.

  14. Dynamic contrast-enhanced perfusion area-detector CT assessed with various mathematical models: Its capability for therapeutic outcome prediction for non-small cell lung cancer patients with chemoradiotherapy as compared with that of FDG-PET/CT.

    Science.gov (United States)

    Ohno, Yoshiharu; Fujisawa, Yasuko; Koyama, Hisanobu; Kishida, Yuji; Seki, Shinichiro; Sugihara, Naoki; Yoshikawa, Takeshi

    2017-01-01

    To directly compare the capability of dynamic first-pass contrast-enhanced (CE-) perfusion area-detector CT (ADCT) and PET/CT for early prediction of treatment response, disease progression and overall survival of non-small cell carcinoma (NSCLC) patients treated with chemoradiotherapy. Fifty-three consecutive Stage IIIB NSCLC patients who had undergone PET/CT, dynamic first-pass CE-perfusion ADCT, chemoradiotherapy, and follow-up examination were enrolled in this study. They were divided into two groups: 1) complete or partial response (CR+PR) and 2) stable or progressive disease (SD+PD). Pulmonary arterial and systemic arterial perfusions and total perfusion were assessed at targeted lesions with the dual-input maximum slope method, permeability surface and distribution volume with the Patlak plot method, tumor perfusion with the single-input maximum slope method, and SUV max , and results were averaged to determine final values for each patient. Next, step-wise regression analysis was used to determine which indices were the most useful for predicting therapeutic effect. Finally, overall survival of responders and non-responders assessed by using the indices that had a significant effect on prediction of therapeutic outcome was statistically compared. The step-wise regression test showed that therapeutic effect (r 2 =0.63, p=0.01) was significantly affected by the following three factors in order of magnitude of impact: systemic arterial perfusion, total perfusion, and SUV max . Mean overall survival showed a significant difference for total perfusion (p=0.003) and systemic arterial perfusion (p=0.04). Dynamic first-pass CE-perfusion ADCT as well as PET/CT are useful for treatment response prediction in NSCLC patients treated with chemoradiotherapy. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  15. Campus Capability Plan

    Energy Technology Data Exchange (ETDEWEB)

    Adams, C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Arsenlis, T. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Bailey, A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Bergman, M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Brase, J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Brenner, J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Camara, L. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Carlton, H. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Cheng, J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Chrzanowski, P. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Colson, J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); East, D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Farrell, J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Ferranti, L. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Gursahani, A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Hansen, R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Helms, L. L. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Hernandez, M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Jeffries, J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Larson, D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Lu, K. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); McNabb, D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Mercer, M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Skeate, M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Sueksdorf, M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Zucca, B. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Le, D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Ancria, R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Scott, J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Leininger, L. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Gagliardi, F. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Gash, A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Bronson, M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Chung, B. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Hobson, B. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Meeker, J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Sanchez, J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Zagar, M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Quivey, B. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Sommer, S. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Atherton, J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-06-06

    Lawrence Livermore National Laboratory Campus Capability Plan for 2018-2028. Lawrence Livermore National Laboratory (LLNL) is one of three national laboratories that are part of the National Nuclear Security Administration. LLNL provides critical expertise to strengthen U.S. security through development and application of world-class science and technology that: Ensures the safety, reliability, and performance of the U.S. nuclear weapons stockpile; Promotes international nuclear safety and nonproliferation; Reduces global danger from weapons of mass destruction; Supports U.S. leadership in science and technology. Essential to the execution and continued advancement of these mission areas are responsive infrastructure capabilities. This report showcases each LLNL capability area and describes the mission, science, and technology efforts enabled by LLNL infrastructure, as well as future infrastructure plans.

  16. Exploration Medical Capability - Technology Watch

    Science.gov (United States)

    Krihak, Michael; Watkins, Sharmila; Barr, Yael; Barsten, Kristina; Fung, Paul; Baumann, David

    2011-01-01

    The objectives of the Technology Watch process are to identify emerging, high-impact technologies that augment current ExMC development efforts, and to work with academia, industry, and other government agencies to accelerate the development of medical care and research capabilities for the mitigation of potential health issues that could occur during space exploration missions. The establishment of collaborations with these entities is beneficial to technology development, assessment and/or insertion. Such collaborations also further NASA s goal to provide a safe and healthy environment for human exploration. The Tech Watch project addresses requirements and capabilities identified by knowledge and technology gaps that are derived from a discrete set of medical conditions that are most likely to occur on exploration missions. These gaps are addressed through technology readiness level assessments, market surveys, collaborations and distributed innovation opportunities. Ultimately, these gaps need to be closed with respect to exploration missions, and may be achieved through technology development projects. Information management is a key aspect to this process where Tech Watch related meetings, research articles, collaborations and partnerships are tracked by the HRP s Exploration Medical Capabilities (ExMC) Element. In 2011, ExMC will be introducing the Tech Watch external website and evidence wiki that will provide access to ExMC technology and knowledge gaps, technology needs and requirements documents.

  17. Capabilities for innovation

    DEFF Research Database (Denmark)

    Nielsen, Peter; Nielsen, Rene Nesgaard; Bamberger, Simon Grandjean

    2012-01-01

    is a survey that collected information from 601 firms belonging to the private urban sector in Denmark. The survey was carried out in late 2010. Keywords: dynamic capabilities/innovation/globalization/employee/employer cooperation/Nordic model Acknowledgment: The GOPA study was financed by grant 20080053113......Technological developments combined with increasing levels of competition related to the ongoing globalization imply that firms find themselves in dynamic, changing environments that call for dynamic capabilities. This challenges the internal human and organizational resources of firms in general...

  18. Human push capability.

    Science.gov (United States)

    Barnett, Ralph L; Liber, Theodore

    2006-02-22

    Use of unassisted human push capability arises from time to time in the areas of crowd and animal control, the security of locked doors, the integrity of railings, the removal of tree stumps and entrenched vehicles, the manoeuvering of furniture, and athletic pursuits such as US football or wrestling. Depending on the scenario, human push capability involves strength, weight, weight distribution, push angle, footwear/floor friction, and the friction between the upper body and the pushed object. Simple models are used to establish the relationships among these factors.

  19. The Capability Approach

    OpenAIRE

    Robeyns, Ingrid

    2011-01-01

    textabstract In its most general description, the capability approach is a flexible and multi-purpose normative framework, rather than a precise theory of well-being, freedom or justice. At its core are two normative claims: first, the claim that the freedom to achieve well-being is of primary moral importance, and second, that freedom to achieve well-being is to be understood in terms of people’s capabilities, that is, their real opportunities to do and be what they have reason to value. Thi...

  20. Sandia QIS Capabilities.

    Energy Technology Data Exchange (ETDEWEB)

    Muller, Richard P. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-07-01

    Sandia National Laboratories has developed a broad set of capabilities in quantum information science (QIS), including elements of quantum computing, quantum communications, and quantum sensing. The Sandia QIS program is built atop unique DOE investments at the laboratories, including the MESA microelectronics fabrication facility, the Center for Integrated Nanotechnologies (CINT) facilities (joint with LANL), the Ion Beam Laboratory, and ASC High Performance Computing (HPC) facilities. Sandia has invested $75 M of LDRD funding over 12 years to develop unique, differentiating capabilities that leverage these DOE infrastructure investments.

  1. Added value of smooth hypointense rim in the hepatobiliary phase of gadoxetic acid-enhanced MRI in identifying tumour capsule and diagnosing hepatocellular carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    An, Chansik; Han, Kyunghwa; Choi, Jin-Young; Park, Mi-Suk; Kim, Myeong-Jin [Yonsei University College of Medicine, Department of Radiology, Research Institute of Radiological Science, Seoul (Korea, Republic of); Rhee, Hyungjin [Yonsei University College of Medicine, Department of Pathology, Brain Korea 21 PLUS Project for Medical Science, Integrated Genomic Research Center for Metabolic Regulation, Seoul (Korea, Republic of); Park, Young-Nyun [Yonsei University College of Medicine, Department of Pathology, Brain Korea 21 PLUS Project for Medical Science, Integrated Genomic Research Center for Metabolic Regulation, Seoul (Korea, Republic of); Yonsei University College of Medicine, Severance Biomedical Science Institute, Seoul (Korea, Republic of); Park, Sumi [National Health Insurance Service Ilsan Hospital, Department of Radiology, Goyang (Korea, Republic of)

    2017-06-15

    To examine the added value of considering smooth hypointense rim in the hepatobiliary phase (HBP) of gadoxetic acid-enhanced MRI as capsule appearance for diagnosing tumour capsules and hepatocellular carcinoma (HCC). A total of 377 hepatic lesions (330 HCCs, 35 non-HCC malignancies and 12 benign) were included from 345 patients who underwent resection after MRI between January 2008 and December 2011. Two radiologists assessed the presence or absence of conventional capsule appearance and smooth hypointense rim in the HBP, and categorized each hepatic lesion according to the Liver Imaging Reporting and Data System. Difference in diagnostic performance was evaluated using the generalized estimating equation method. For identifying capsule, the sensitivity and accuracy of HBP hypointense rim were significantly higher than those of conventional capsule appearance (81.5 % vs. 57.8 % and 76.1 % vs. 59.4 %, respectively; P < 0.001). For diagnosing HCC, the sensitivity and accuracy of LR-5 or LR-5 V were significantly higher when the HBP hypointense rim was also considered capsule appearance (83 % vs. 72.7 % and 84.1 % vs. 75.1 %, respectively; P < 0.001), with the same specificity (91.5 %). Regarding smooth hypointense rim in the HBP as capsule appearance could improve the detection of tumour capsule and the diagnosis of HCC. (orig.)

  2. Developing Acquisition IS Integration Capabilities

    DEFF Research Database (Denmark)

    Wynne, Peter J.

    2016-01-01

    An under researched, yet critical challenge of Mergers and Acquisitions (M&A), is what to do with the two organisations’ information systems (IS) post-acquisition. Commonly referred to as acquisition IS integration, existing theory suggests that to integrate the information systems successfully......, an acquiring company must leverage two high level capabilities: diagnosis and integration execution. Through a case study, this paper identifies how a novice acquirer develops these capabilities in anticipation of an acquisition by examining its use of learning processes. The study finds the novice acquirer...... applies trial and error, experimental, and vicarious learning processes, while actively avoiding improvisational learning. The results of the study contribute to the acquisition IS integration literature specifically by exploring it from a new perspective: the learning processes used by novice acquirers...

  3. TBEST model enhancements : parcel level demographic data capabilities and exploration of enhanced trip attraction capabilities.

    Science.gov (United States)

    2011-09-01

    "FDOT, in pursuit of its role to assist in providing public transportation services in Florida, has made a substantial : research investment in a travel demand forecasting tool for public transportation known as Transit Boardings : Estimation and Sim...

  4. ISOPHOT - Capabilities and performance

    DEFF Research Database (Denmark)

    Lemke, D.; Klaas, U.; Abolins, J.

    1996-01-01

    ISOPHOT covers the largest wavelength range on ISO from 2.5 to 240 mu m. Its scientific capabilities include multi filter and multi-aperture photometry, polarimetry, imaging and spectrophotometry. All modes can optionally include a focal plane chopper. The backbone of the photometric calibration...

  5. Capabilities for Intercultural Dialogue

    Science.gov (United States)

    Crosbie, Veronica

    2014-01-01

    The capabilities approach offers a valuable analytical lens for exploring the challenge and complexity of intercultural dialogue in contemporary settings. The central tenets of the approach, developed by Amartya Sen and Martha Nussbaum, involve a set of humanistic goals including the recognition that development is a process whereby people's…

  6. Capabilities and Special Needs

    DEFF Research Database (Denmark)

    Kjeldsen, Christian Christrup

    into international consideration in relation to the implementation of the UN convention on the rights of persons with disabilities. As for the theoretical basis, the research makes use of the sociological open-ended and relational concepts of Pierre Bourdieu and the normative yardstick of the Capability Approach...

  7. Metrology Measurement Capabilities

    Energy Technology Data Exchange (ETDEWEB)

    Dr. Glen E. Gronniger

    2007-10-02

    This document contains descriptions of Federal Manufacturing & Technologies (FM&T) Metrology capabilities, traceability flow charts, and the measurement uncertainty of each measurement capability. Metrology provides NIST traceable precision measurements or equipment calibration for a wide variety of parameters, ranges, and state-of-the-art uncertainties. Metrology laboratories conform to the requirements of the Department of Energy Development and Production Manual Chapter 13.2, ANSI/ISO/IEC ANSI/ISO/IEC 17025:2005, and ANSI/NCSL Z540-1. FM&T Metrology laboratories are accredited by NVLAP for the parameters, ranges, and uncertainties listed in the specific scope of accreditation under NVLAP Lab code 200108-0. See the Internet at http://ts.nist.gov/Standards/scopes/2001080.pdf. These parameters are summarized. The Honeywell Federal Manufacturing & Technologies (FM&T) Metrology Department has developed measurement technology and calibration capability in four major fields of measurement: (1) Mechanical; (2) Environmental, Gas, Liquid; (3) Electrical (DC, AC, RF/Microwave); and (4) Optical and Radiation. Metrology Engineering provides the expertise to develop measurement capabilities for virtually any type of measurement in the fields listed above. A strong audit function has been developed to provide a means to evaluate the calibration programs of our suppliers and internal calibration organizations. Evaluation includes measurement audits and technical surveys.

  8. The Capability Approach

    NARCIS (Netherlands)

    I.A.M. Robeyns (Ingrid)

    2011-01-01

    textabstract In its most general description, the capability approach is a flexible and multi-purpose normative framework, rather than a precise theory of well-being, freedom or justice. At its core are two normative claims: first, the claim that the freedom to achieve well-being is of primary

  9. Sensor Alerting Capability

    Science.gov (United States)

    Henriksson, Jakob; Bermudez, Luis; Satapathy, Goutam

    2013-04-01

    There is a large amount of sensor data generated today by various sensors, from in-situ buoys to mobile underwater gliders. Providing sensor data to the users through standardized services, language and data model is the promise of OGC's Sensor Web Enablement (SWE) initiative. As the amount of data grows it is becoming difficult for data providers, planners and managers to ensure reliability of data and services and to monitor critical data changes. Intelligent Automation Inc. (IAI) is developing a net-centric alerting capability to address these issues. The capability is built on Sensor Observation Services (SOSs), which is used to collect and monitor sensor data. The alerts can be configured at the service level and at the sensor data level. For example it can alert for irregular data delivery events or a geo-temporal statistic of sensor data crossing a preset threshold. The capability provides multiple delivery mechanisms and protocols, including traditional techniques such as email and RSS. With this capability decision makers can monitor their assets and data streams, correct failures or be alerted about a coming phenomena.

  10. Identity Building in Organisations: Proactive Capability Development

    DEFF Research Database (Denmark)

    Rasmussen, Lauge Baungaard

    2002-01-01

    Identity building in organisations is often viewed as legitimacy of value systems of the organisation. Based on empirical studies the task of this article is to argue that such a legitimacy approach risks failing in the longer perspective, if the proactive capability development is neglected....... The participatory scenario method presented in this article is one of the possible methods to enhance identity building based on proactive capability development....

  11. Tomato PYR/PYL/RCAR abscisic acid receptors show high expression in root, differential sensitivity to the abscisic acid agonist quinabactin, and the capability to enhance plant drought resistance.

    Science.gov (United States)

    González-Guzmán, Miguel; Rodríguez, Lesia; Lorenzo-Orts, Laura; Pons, Clara; Sarrión-Perdigones, Alejandro; Fernández, Maria A; Peirats-Llobet, Marta; Forment, Javier; Moreno-Alvero, Maria; Cutler, Sean R; Albert, Armando; Granell, Antonio; Rodríguez, Pedro L

    2014-08-01

    Abscisic acid (ABA) plays a crucial role in the plant's response to both biotic and abiotic stress. Sustainable production of food faces several key challenges, particularly the generation of new varieties with improved water use efficiency and drought tolerance. Different studies have shown the potential applications of Arabidopsis PYR/PYL/RCAR ABA receptors to enhance plant drought resistance. Consequently the functional characterization of orthologous genes in crops holds promise for agriculture. The full set of tomato (Solanum lycopersicum) PYR/PYL/RCAR ABA receptors have been identified here. From the 15 putative tomato ABA receptors, 14 of them could be grouped in three subfamilies that correlated well with corresponding Arabidopsis subfamilies. High levels of expression of PYR/PYL/RCAR genes was found in tomato root, and some genes showed predominant expression in leaf and fruit tissues. Functional characterization of tomato receptors was performed through interaction assays with Arabidopsis and tomato clade A protein phosphatase type 2Cs (PP2Cs) as well as phosphatase inhibition studies. Tomato receptors were able to inhibit the activity of clade A PP2Cs differentially in an ABA-dependent manner, and at least three receptors were sensitive to the ABA agonist quinabactin, which inhibited tomato seed germination. Indeed, the chemical activation of ABA signalling induced by quinabactin was able to activate stress-responsive genes. Both dimeric and monomeric tomato receptors were functional in Arabidopsis plant cells, but only overexpression of monomeric-type receptors conferred enhanced drought resistance. In summary, gene expression analyses, and chemical and transgenic approaches revealed distinct properties of tomato PYR/PYL/RCAR ABA receptors that might have biotechnological implications. © The Author 2014. Published by Oxford University Press on behalf of the Society for Experimental Biology.

  12. Conceptualizing innovation capabilities: A contingency perspective

    Directory of Open Access Journals (Sweden)

    Tor Helge Aas

    2017-01-01

    Full Text Available Empirical research has confirmed that a positive relationship exists between the implementation of innovation activities and the future performance of organizations. Firms utilize resources and capabilities to develop innovations in the form of new products, services or processes. Some firms prove to be better at reproducing innovation success than others, and the capacity to do so is referred to as innovation capability. However, the term innovation capability is ambiguously treated in extant literature. There are several different definitions of the concept and the distinction between innovation capabilities and other types of capabilities, such as dynamic capabilities, is neither explicitly stated, nor is the relationship between the concept and other resource- and capability-based concepts within strategy theory established. Although innovation is increasingly identified as crucial for a firm’s sustainable competitiveness in contemporary volatile and complex markets, the strategy-innovation link is underdeveloped in extant research. To overcome this challenge this paper raises the following research question: What type of innovation capabilities are required to innovate successfully? Due to the status of the extant research, we chose a conceptual research design to answer our research question and the paper contributes with a conceptual framework to discuss what innovation capabilities firms need to reproduce innovation success. Based on careful examination of current literature on innovation capability specifically, and the strategy-innovation link in general, we suggest that innovation capability must be viewed along two dimensions – innovation novelty and market characteristics. This framework enables the identification of four different contexts for innovation capabilities in a two-bytwo matrix. We discuss the types of innovation capabilities necessary within the four different contexts. This novel framework contributes to the

  13. Dynamic contrast-enhanced, extremity-dedicated MRI identifies synovitis changes in the follow-up of rheumatoid arthritis patients treated with rituximab

    DEFF Research Database (Denmark)

    Cimmino, Marco A; Parodi, Massimiliano; Zampogna, Giuseppe

    2014-01-01

    according to the 1987 ACR criteria were treated with a single course of RTX (2 infusions of 1000 mg, 15 days apart). MRI of the dominant hand was performed with a 0.2T extremity-dedicated machine using pre and post contrast T1 weighted SE, turbo 3D, and STIR sequences at baseline, and after 4 and 24 weeks....... MRI was analysed using the OMERACT-RAMRIS score and the dynamic contrast-enhanced (DCE-MRI) technique for wrist synovitis, which calculates the enhancement ratio as both rate of early enhancement (REE) and relative enhancement (RE). The corresponding ME and IRE parameters were calculated also through...

  14. Atmospheric Release Advisory Capability

    International Nuclear Information System (INIS)

    Dickerson, M.H.; Gudiksen, P.H.; Sullivan, T.J.

    1983-02-01

    The Atmospheric Release Advisory Capability (ARAC) project is a Department of Energy (DOE) sponsored real-time emergency response service available for use by both federal and state agencies in case of a potential or actual atmospheric release of nuclear material. The project, initiated in 1972, is currently evolving from the research and development phase to full operation. Plans are underway to expand the existing capability to continuous operation by 1984 and to establish a National ARAC Center (NARAC) by 1988. This report describes the ARAC system, its utilization during the past two years, and plans for its expansion during the next five to six years. An integral part of this expansion is due to a very important and crucial effort sponsored by the Defense Nuclear Agency to extend the ARAC service to approximately 45 Department of Defense (DOD) sites throughout the continental US over the next three years

  15. Graphical Visualization of Human Exploration Capabilities

    Science.gov (United States)

    Rodgers, Erica M.; Williams-Byrd, Julie; Arney, Dale C.; Simon, Matthew A.; Williams, Phillip A.; Barsoum, Christopher; Cowan, Tyler; Larman, Kevin T.; Hay, Jason; Burg, Alex

    2016-01-01

    NASA's pioneering space strategy will require advanced capabilities to expand the boundaries of human exploration on the Journey to Mars (J2M). The Evolvable Mars Campaign (EMC) architecture serves as a framework to identify critical capabilities that need to be developed and tested in order to enable a range of human exploration destinations and missions. Agency-wide System Maturation Teams (SMT) are responsible for the maturation of these critical exploration capabilities and help formulate, guide and resolve performance gaps associated with the EMC-identified capabilities. Systems Capability Organization Reporting Engine boards (SCOREboards) were developed to integrate the SMT data sets into cohesive human exploration capability stories that can be used to promote dialog and communicate NASA's exploration investments. Each SCOREboard provides a graphical visualization of SMT capability development needs that enable exploration missions, and presents a comprehensive overview of data that outlines a roadmap of system maturation needs critical for the J2M. SCOREboards are generated by a computer program that extracts data from a main repository, sorts the data based on a tiered data reduction structure, and then plots the data according to specified user inputs. The ability to sort and plot varying data categories provides the flexibility to present specific SCOREboard capability roadmaps based on customer requests. This paper presents the development of the SCOREboard computer program and shows multiple complementary, yet different datasets through a unified format designed to facilitate comparison between datasets. Example SCOREboard capability roadmaps are presented followed by a discussion of how the roadmaps are used to: 1) communicate capability developments and readiness of systems for future missions, and 2) influence the definition of NASA's human exploration investment portfolio through capability-driven processes. The paper concludes with a description

  16. Developing A/E Capabilities

    International Nuclear Information System (INIS)

    Gonzalez, A.; Gurbindo, J.

    1987-01-01

    During the last few years, the methods used by EMPRESARIOS AGRUPADOS and INITEC to perform Architect-Engineering work in Spain for nuclear projects has undergone a process of significant change in project management and engineering approaches. Specific practical examples of management techniques and design practices which represent a good record of results will be discussed. They are identified as areas of special interest in developing A/E capabilities for nuclear projects . Command of these areas should produce major payoffs in local participation and contribute to achieving real nuclear engineering capabities in the country. (author)

  17. Group Capability Model

    Science.gov (United States)

    Olejarski, Michael; Appleton, Amy; Deltorchio, Stephen

    2009-01-01

    The Group Capability Model (GCM) is a software tool that allows an organization, from first line management to senior executive, to monitor and track the health (capability) of various groups in performing their contractual obligations. GCM calculates a Group Capability Index (GCI) by comparing actual head counts, certifications, and/or skills within a group. The model can also be used to simulate the effects of employee usage, training, and attrition on the GCI. A universal tool and common method was required due to the high risk of losing skills necessary to complete the Space Shuttle Program and meet the needs of the Constellation Program. During this transition from one space vehicle to another, the uncertainty among the critical skilled workforce is high and attrition has the potential to be unmanageable. GCM allows managers to establish requirements for their group in the form of head counts, certification requirements, or skills requirements. GCM then calculates a Group Capability Index (GCI), where a score of 1 indicates that the group is at the appropriate level; anything less than 1 indicates a potential for improvement. This shows the health of a group, both currently and over time. GCM accepts as input head count, certification needs, critical needs, competency needs, and competency critical needs. In addition, team members are categorized by years of experience, percentage of contribution, ex-members and their skills, availability, function, and in-work requirements. Outputs are several reports, including actual vs. required head count, actual vs. required certificates, CGI change over time (by month), and more. The program stores historical data for summary and historical reporting, which is done via an Excel spreadsheet that is color-coded to show health statistics at a glance. GCM has provided the Shuttle Ground Processing team with a quantifiable, repeatable approach to assessing and managing the skills in their organization. They now have a common

  18. Expeditionary Rubber Removal Capability

    Science.gov (United States)

    2006-12-31

    the modified spray unit or system with equivalent capabilities. 24 25 9.8. A pressure sensor or caster wheels should be incorporated into the...DISCUSSION 18 8.0 CONCLUSIONS 23 9.0 RECOMMENDATIONS 24 APPENDIX A – DETAILED LIST OF EQUIPMENT AND MODIFICATIONS 26 APPENDIX B – LIST OF SOURCES FOR...tall Weight – 4820 lb (No Attachments) Top Speed – 18 mph High Flow Hydraulics (Optional) – 26 gpm Steering – All Wheel Steering Cargo Max Load

  19. Atmospheric release advisory capability

    International Nuclear Information System (INIS)

    Sullivan, T.J.

    1981-01-01

    The ARAC system (Atmospheric Release Advisory Capability) is described. The system is a collection of people, computers, computer models, topographic data and meteorological input data that together permits a calculation of, in a quasi-predictive sense, where effluent from an accident will migrate through the atmosphere, where it will be deposited on the ground, and what instantaneous and integrated dose an exposed individual would receive

  20. An innovative approach to capability-based emergency operations planning.

    Science.gov (United States)

    Keim, Mark E

    2013-01-01

    This paper describes the innovative use information technology for assisting disaster planners with an easily-accessible method for writing and improving evidence-based emergency operations plans. This process is used to identify all key objectives of the emergency response according to capabilities of the institution, community or society. The approach then uses a standardized, objective-based format, along with a consensus-based method for drafting capability-based operational-level plans. This information is then integrated within a relational database to allow for ease of access and enhanced functionality to search, sort and filter and emergency operations plan according to user need and technological capacity. This integrated approach is offered as an effective option for integrating best practices of planning with the efficiency, scalability and flexibility of modern information and communication technology.

  1. Building Server Capabilities

    DEFF Research Database (Denmark)

    Adeyemi, Oluseyi

    2013-01-01

    Many western companies have moved part of their operations to China in order to take advantage of cheap resources and/or to gain access to a high potential market. Depending on motive, offshore facilities usually start either as “sales-only” of products exported by headquarters or “production......-only”, exporting parts and components back to headquarter for sales in the home country. In the course of time, the role of offshore subsidiaries in a company’s operations network tends to change and, with that, the capabilities, of the subsidiaries. Focusing on Danish subsidiaries in China, the objective...

  2. Building server capabilities

    DEFF Research Database (Denmark)

    Adeyemi, Oluseyi

    Many western companies have moved part of their operations to China in order to take advantage of cheap resources and/or to gain access to a high potential market. Depending on motive, offshore facilities usually start either as “sales-only” of products exported by headquarters or “production......-only”, exporting parts and components back to headquarter for sales in the home country. In the course of time, the role of offshore subsidiaries in a company’s operations network tends to change and, with that, the capabilities, of the subsidiaries. Focusing on Danish subsidiaries in China, the objective...

  3. Organizational Strategic Learning Capability: Exploring the Dimensions

    Science.gov (United States)

    Moon, Hanna; Sejong, Wendy; Valentine, Tom

    2017-01-01

    Purpose: How to build and enhance the strategic learning capability (SLC) of an organization becomes crucial to both research and practice. This study was designed with the purpose to conceptualize SLC by translating and interpreting the related literature to develop empirical dimensions that could be tested and used in a survey instrument.…

  4. Uncovering Dynamic Capabilities for Service Innovation: Conceptualization and Measurement

    NARCIS (Netherlands)

    Janssen, M.; Alexiev, A.S.; Castaldi, C.; Den Hertog, P.

    2013-01-01

    The dynamic capabilities view (DCV) is in need of a solid empirical grounding. Existing attempts to identify the organizational behaviour (or microfoundations) on which dynamic capabilities rely are largely biased towards manufacturing. Thereby, these conceptualizations overlook some of the aspects

  5. Canadian national nuclear forensics capability project

    International Nuclear Information System (INIS)

    Ball, J.; Dimayuga, I.; Summerell, I.; Totland, M.; Jonkmans, G.; Whitlock, J.; El-jaby, A.; Inrig, E.

    2015-01-01

    Following the 2010 Nuclear Security Summit, Canada expanded its existing capability for nuclear forensics by establishing a national nuclear forensics laboratory network, which would include a capability to perform forensic analysis on nuclear and other radioactive material, as well as on traditional evidence contaminated with radioactive material. At the same time, the need for a national nuclear forensics library of signatures of nuclear and radioactive materials under Canadian regulatory control was recognized. The Canadian Safety and Security Program, administered by Defence Research and Development Canada's Centre for Security Science (DRDC CSS), funds science and technology initiatives to enhance Canada's preparedness for prevention of and response to potential threats. DRDC CSS, with assistance from Canadian Nuclear Laboratories, formerly Atomic Energy of Canada Limited, is leading the Canadian National Nuclear Forensics Capability Project to develop a coordinated, comprehensive, and timely national nuclear forensics capability. (author)

  6. Canadian national nuclear forensics capability project

    Energy Technology Data Exchange (ETDEWEB)

    Ball, J.; Dimayuga, I., E-mail: joanne.ball@cnl.ca [Canadian Nuclear Laboratories, Chalk River, Ontario (Canada); Summerell, I. [Royal Canadian Mounted Police, Ottawa, Ontario (Canada); Totland, M. [Canadian Nuclear Laboratories, Chalk River, Ontario (Canada); Jonkmans, G. [Defence Research and Development Canada, Ottawa, Ontario (Canada); Whitlock, J. [Canadian Nuclear Laboratories, Chalk River, Ontario (Canada); El-jaby, A. [Canadian Nuclear Safety Commission, Ottawa, Ontario (Canada); Inrig, E. [Defence Research and Development Canada, Ottawa, Ontario (Canada)

    2015-06-15

    Following the 2010 Nuclear Security Summit, Canada expanded its existing capability for nuclear forensics by establishing a national nuclear forensics laboratory network, which would include a capability to perform forensic analysis on nuclear and other radioactive material, as well as on traditional evidence contaminated with radioactive material. At the same time, the need for a national nuclear forensics library of signatures of nuclear and radioactive materials under Canadian regulatory control was recognized. The Canadian Safety and Security Program, administered by Defence Research and Development Canada's Centre for Security Science (DRDC CSS), funds science and technology initiatives to enhance Canada's preparedness for prevention of and response to potential threats. DRDC CSS, with assistance from Canadian Nuclear Laboratories, formerly Atomic Energy of Canada Limited, is leading the Canadian National Nuclear Forensics Capability Project to develop a coordinated, comprehensive, and timely national nuclear forensics capability. (author)

  7. Using Porterian Activity Analysis to Understand Organizational Capabilities

    DEFF Research Database (Denmark)

    Sheehan, Norman T.; Foss, Nicolai Juul

    2017-01-01

    conceptualized by Porter’s writings on the activity-based view. Porterian activity analysis is becoming more accepted in the strategy literature, but no strategy scholar has explicitly used Porter’s activities, and particularly his concept of drivers, to understand and analyze organizational capabilities....... Introducing Porterian activities into the discussion of capabilities improves strategy scholars’ understanding of the bases of capability heterogeneity, offers academics future directions for research, and provides managers with guidance to enhance their organizations’ capabilities....

  8. Community psychology and the capabilities approach.

    Science.gov (United States)

    Shinn, Marybeth

    2015-06-01

    What makes for a good life? The capabilities approach to this question has much to offer community psychology, particularly with respect to marginalized groups. Capabilities are freedoms to engage in valued social activities and roles-what people can do and be given both their capacities, and environmental opportunities and constraints. Economist Amartya Sen's focus on freedoms and agency resonates with psychological calls for empowerment, and philosopher Martha Nussbaum's specification of requirements for a life that is fully human provides an important guide for social programs. Community psychology's focus on mediating structures has much to offer the capabilities approach. Parallels between capabilities, as enumerated by Nussbaum, and settings that foster positive youth development, as described in a National Research Council Report (Eccles and Gootman (Eds) in Community programs to promote youth development. National Academy Press, Washington, 2002) suggest extensions of the approach to children. Community psychologists can contribute to theory about ways to create and modify settings to enhance capabilities as well as empowerment and positive youth development. Finally, capabilities are difficult to measure, because they involve freedoms to choose but only choices actually made or enacted can be observed. The variation in activities or goals across members of a setting provides a measure of the capabilities that the setting fosters.

  9. Descriptors of server capabilities in China

    DEFF Research Database (Denmark)

    Adeyemi, Oluseyi; Slepniov, Dmitrij; Wæhrens, Brian Vejrum

    are relevant to determine subsidiary roles and as an indication of the capabilities required. These descriptors are identified through extensive literature review and validated by case studies of two Danish multinational companies subsidiaries operating in China. They provided the empirical basis......China with the huge market potential it possesses is an important issue for subsidiaries of western multinational companies. The objective of this paper is therefore to strengthen researchers’ and practitioners’ perspectives on what are the descriptors of server capabilities. The descriptors...

  10. Technological Innovation Capabilities and Firm Performance

    OpenAIRE

    Richard C.M. Yam; William Lo; Esther P.Y. Tang; Antonio; K.W. Lau

    2010-01-01

    Technological innovation capability (TIC) is defined as a comprehensive set of characteristics of a firm that facilities and supports its technological innovation strategies. An audit to evaluate the TICs of a firm may trigger improvement in its future practices. Such an audit can be used by the firm for self assessment or third-party independent assessment to identify problems of its capability status. This paper attempts to develop such an auditing framework that can...

  11. Using Raman Spectroscopy and Surface-Enhanced Raman Scattering to Identify Colorants in Art: An Experiment for an Upper-Division Chemistry Laboratory

    Science.gov (United States)

    Mayhew, Hannah E.; Frano, Kristen A.; Svoboda, Shelley A.; Wustholz, Kristin L.

    2015-01-01

    Surface-enhanced Raman scattering (SERS) studies of art represent an attractive way to introduce undergraduate students to concepts in nanoscience, vibrational spectroscopy, and instrumental analysis. Here, we present an undergraduate analytical or physical chemistry laboratory wherein a combination of normal Raman and SERS spectroscopy is used to…

  12. Available decontamination and decommissioning capabilities at the Savannah River Technology Center

    International Nuclear Information System (INIS)

    Polizzi, L.M.; Norkus, J.K.; Paik, I.K.; Wooten, L.A.

    1992-01-01

    The Safety Analysis and Engineering Services Group has performed a survey of the Savannah River Technology Center (SRTC) technical capabilities, skills, and experience in Decontamination and Decommissioning (D ampersand D) activities. The goal of this survey is to enhance the integration of the SRTC capabilities with the technical needs of the Environmental Restoration Department D ampersand D program and the DOE Office of Technology Development through the Integrated Demonstration Program. This survey has identified technical capabilities, skills, and experience in the following D ampersand D areas: Characterization, Decontamination, Dismantlement, Material Disposal, Remote Systems, and support on Safety Technology for D ampersand D. This review demonstrates the depth and wealth of technical capability resident in the SRTC in relation to these activities, and the unique qualifications of the SRTC to supply technical support in the area of DOE facility D ampersand D. Additional details on specific technologies and applications to D ampersand D will be made available on request

  13. Aircraft Capability Management

    Science.gov (United States)

    Mumaw, Randy; Feary, Mike

    2018-01-01

    This presentation presents an overview of work performed at NASA Ames Research Center in 2017. The work concerns the analysis of current aircraft system management displays, and the initial development of an interface for providing information about aircraft system status. The new interface proposes a shift away from current aircraft system alerting interfaces that report the status of physical components, and towards displaying the implications of degradations on mission capability. The proposed interface describes these component failures in terms of operational consequences of aircraft system degradations. The research activity was an effort to examine the utility of different representations of complex systems and operating environments to support real-time decision making of off-nominal situations. A specific focus was to develop representations that provide better integrated information to allow pilots to more easily reason about the operational consequences of the off-nominal situations. The work is also seen as a pathway to autonomy, as information is integrated and understood in a form that automated responses could be developed for the off-nominal situations in the future.

  14. Production capability and supply

    International Nuclear Information System (INIS)

    Klemenic, J.

    1977-01-01

    The strong market for uranium of recent years is about to usher in a new era in domestic uranium production. The spot market price of uranium has remained relatively stable at a little over $40/lb for more than 18 months. Many of the recent contracts for delivery in the early 1980s are calling for prices in the range of $40 to $65 per lb in year-of-delivery dollars. Low-grade, high-cost projects, such as uranium recovery from mill tailings and the reopening of ''mined-out'' ore bodies, have already been initiated. New underground mines to produce at greater depths, and new surface mines to recover lower grade ores, are being developed or seriously planned. In keeping with this movement to recover uranium from low-grade ore and other high cost materials, the Grand Junction Office has examined, for the first time, the production capability of the domestic industry assuming a $30/lb (or less) ''forward cost'' resource base. As in the past, keep in mind that the market price needed to stimulate full production of a given resource base may be significantly higher than the estimated forward cost of producing that resource. Results of the $30/lb study are presented

  15. LHC Capabilities for Quarkonia

    CERN Document Server

    Petrushanko, Sergey

    2008-01-01

    The measurement of the charmonium and bottomonium resonances in nucleus-nucleus collisions provides crucial information on high-density QCD matter. First, the suppression of quarkonia production is generally agreed to be one of the most direct probes of quark-gluon plasma formation. The observation of anomalous J/$\\psi$ suppression at the CERN-SPS and at RHIC is well established but the clarification of some important remaining questions requires equivalent studies of the $\\Upsilon$ family, only possible at the LHC energies. Second, the production of heavy-quarks proceeds mainly via gluon-gluon fusion processes and, as such, is sensitive to saturation of the gluon density at low-x in the nucleus. Measured departures from the expected vacuum quarkonia cross-sections in Pb+Pb collisions at the LHC will thus provide valuable information not only on the thermodynamical state of the produced partonic medium, but also on the initial-state modifications of the nuclear parton distribution functions. The capabilities ...

  16. Mobile systems capability plan

    International Nuclear Information System (INIS)

    1996-09-01

    This plan was prepared to initiate contracting for and deployment of these mobile system services. 102,000 cubic meters of retrievable, contact-handled TRU waste are stored at many sites around the country. Also, an estimated 38,000 cubic meters of TRU waste will be generated in the course of waste inventory workoff and continuing DOE operations. All the defense TRU waste is destined for disposal in WIPP near Carlsbad NM. To ship TRU waste there, sites must first certify that the waste meets WIPP waste acceptance criteria. The waste must be characterized, and if not acceptable, subjected to additional processing, including repackaging. Most sites plan to use existing fixed facilities or open new ones between FY1997-2006 to perform these functions; small-quantity sites lack this capability. An alternative to fixed facilities is the use of mobile systems mounted in trailers or skids, and transported to sites. Mobile systems will be used for all characterization and certification at small sites; large sites can also use them. The Carlsbad Area Office plans to pursue a strategy of privatization of mobile system services, since this offers a number of advantages. To indicate the possible magnitude of the costs of deploying mobile systems, preliminary estimates of equipment, maintenance, and operating costs over a 10-year period were prepared and options for purchase, lease, and privatization through fixed-price contracts considered

  17. Strength capability while kneeling.

    Science.gov (United States)

    Haslegrave, C M; Tracy, M F; Corlett, E N

    1997-12-01

    Work sometimes has to be carried out kneeling, particularly where jobs are performed in confined spaces as is common for miners, aircraft baggage handlers and maintenance workers. In order to assess the risks in performing forceful tasks under such conditions, data is needed on strength capabilities of kneeling subjects. A study was undertaken to measure isometric strength in single-handed exertions for male subjects and to investigate the effects on this of task layout factors (direction of force exertion, reach distance, height of the workpiece and orientation relative to the subject's sagittal plane). The data has been tabulated to show the degree to which strength may be reduced in different situations and analysis of the task factors showed their influence to be complex with direction of exertion and reach distance having the greatest effect. The results also suggest that exertions are weaker when subjects are kneeling on two knees than when kneeling on one knee, although this needs to be confirmed by direct experimental comparison.

  18. Extension of TRIGA reactor capabilities

    International Nuclear Information System (INIS)

    Gietzen, A.J.

    1980-01-01

    The first TRIGA reactor went into operation at 10 kW about 22 years ago. Since that time 55 TRIGAs have been put into operation including steady-state powers up to 14,000 kW and pulsing reactors that pulse to 20,000,000 kW. Five more are under construction and a proposal will soon be submitted for a reactor of 25,000 kW. Along with these increases in power levels (and the corresponding fluxes) the experimental facilities have also been expanded. In addition to the installation of new TRIGA reactors with enhanced capabilities many of the older reactors have been modified and upgraded. Also, a number of reactors originally fueled with plate fuel were converted to TRIGA fuel to take advantage of the improved technical and safety characteristics, including the ability for pulsed operation. In order to accommodate increased power and performance the fuel has undergone considerable evolution. Most of the changes have been in the geometry, enrichment and cladding material. However, more recently further development on the UZrH alloy has been carried out to extend the uranium content up to 45% by weight. This increased U content is necessary to allow the use of less than 20% enrichment in the higher powered reactors while maintaining longer core lifetime. The instrumentation and control system has undergone remarkable improvement as the electronics technology has evolved so rapidly in the last two decades. The information display and the circuitry logic has also undergone improvements for enhanced ease of operation and safety. (author)

  19. Sandia Laboratories technical capabilities. Auxiliary capabilities: environmental health information science

    International Nuclear Information System (INIS)

    1975-09-01

    Sandia Laboratories is an engineering laboratory in which research, development, testing, and evaluation capabilities are integrated by program management for the generation of advanced designs. In fulfilling its primary responsibility to ERDA, Sandia Laboratories has acquired extensive research and development capabilities. The purpose of this series of documents is to catalog the many technical capabilities of the Laboratories. After the listing of capabilities, supporting information is provided in the form of highlights, which show applications. This document deals with auxiliary capabilities, in particular, environmental health and information science. (11 figures, 1 table) (RWR)

  20. Sandia Laboratories technical capabilities: testing

    International Nuclear Information System (INIS)

    Lundergan, C.D.

    1975-12-01

    The testing capabilities at Sandia Laboratories are characterized. Selected applications of these capabilities are presented to illustrate the extent to which they can be applied in research and development programs

  1. Sandia Laboratories technical capabilities: electronics

    International Nuclear Information System (INIS)

    Lundergan, C.D.

    1975-12-01

    This report characterizes the electronics capabilities at Sandia Laboratories. Selected applications of these capabilities are presented to illustrate the extent to which they can be applied in research and development programs

  2. Evaluating Internal Technological Capabilities in Energy Companies

    Directory of Open Access Journals (Sweden)

    Mingook Lee

    2016-03-01

    Full Text Available As global competition increases, technological capability must be evaluated objectively as one of the most important factors for predominance in technological competition and to ensure sustainable business excellence. Most existing capability evaluation models utilize either quantitative methods, such as patent analysis, or qualitative methods, such as expert panels. Accordingly, they may be in danger of reflecting only fragmentary aspects of technological capabilities, and produce inconsistent results when different models are used. To solve these problems, this paper proposes a comprehensive framework for evaluating technological capabilities in energy companies by considering the complex properties of technological knowledge. For this purpose, we first explored various factors affecting technological capabilities and divided the factors into three categories: individual, organizational, and technology competitiveness. Second, we identified appropriate evaluation items for each category to measure the technological capability. Finally, by using a hybrid approach of qualitative and quantitative methods, we developed an evaluation method for each item and suggested a method to combine the results. The proposed framework was then verified with an energy generation and supply company to investigate its practicality. As one of the earliest attempts to evaluate multi-faceted technological capabilities, the suggested model can support technology and strategic planning.

  3. The health informatics cohort enhancement project (HICE: using routinely collected primary care data to identify people with a lifetime diagnosis of psychotic disorder

    Directory of Open Access Journals (Sweden)

    Economou Alexis

    2012-02-01

    Full Text Available Abstract Background We have previously demonstrated that routinely collected primary care data can be used to identify potential participants for trials in depression [1]. Here we demonstrate how patients with psychotic disorders can be identified from primary care records for potential inclusion in a cohort study. We discuss the strengths and limitations of this approach; assess its potential value and report challenges encountered. Methods We designed an algorithm with which we searched for patients with a lifetime diagnosis of psychotic disorders within the Secure Anonymised Information Linkage (SAIL database of routinely collected health data. The algorithm was validated against the "gold standard" of a well established operational criteria checklist for psychotic and affective illness (OPCRIT. Case notes of 100 patients from a community mental health team (CMHT in Swansea were studied of whom 80 had matched GP records. Results The algorithm had favourable test characteristics, with a very good ability to detect patients with psychotic disorders (sensitivity > 0.7 and an excellent ability not to falsely identify patients with psychotic disorders (specificity > 0.9. Conclusions With certain limitations our algorithm can be used to search the general practice data and reliably identify patients with psychotic disorders. This may be useful in identifying candidates for potential inclusion in cohort studies.

  4. Utility of USPIO-enhanced MR imaging to identify inflammation and the fibrous cap: A comparison of symptomatic and asymptomatic individuals

    Energy Technology Data Exchange (ETDEWEB)

    Howarth, S.P.S. [University Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 2QQ (United Kingdom); Tang, T.Y. [University Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 2QQ (United Kingdom); Cambridge Vascular Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge (United Kingdom); Trivedi, R.; Weerakkody, R.; U-King-Im, J. [University Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 2QQ (United Kingdom); Gaunt, M.E.; Boyle, J.R. [Cambridge Vascular Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge (United Kingdom); Li, Z.Y. [University Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 2QQ (United Kingdom); Miller, S.R. [Biostatistics and Data Sciences, GlaxoSmithKline, Harlow (United Kingdom); Graves, M.J. [University Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 2QQ (United Kingdom); Gillard, J.H. [University Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 2QQ (United Kingdom)], E-mail: jhg21@cam.ac.uk

    2009-06-15

    Background and purpose: Inflammation is a risk factor the vulnerable atheromatous plaque. This can be detected in vivo on high-resolution magnetic resonance (MR) imaging using a contrast agent, Sinerem{sup TM}, an ultra-small super-paramagnetic iron oxide (USPIO). The aim of this study was to explore whether there is a difference in the degree of MR defined inflammation using USPIO particles, between symptomatic and asymptomatic carotid plaques. We report further on its T{sub 1} effect of enhancing the fibrous cap, which may allow dual contrast resolution of carotid atheroma. Methods: Twenty patients with carotid stenosis (10 symptomatic and 10 asymptomatic) underwent multi-sequence MR imaging before and 36 h post-USPIO infusion. Images were manually segmented into quadrants and signal change in each quadrant was calculated following USPIO administration. Mean signal change across all quadrants were compared between the two groups. Results: Symptomatic patients had significantly more quadrants with a signal drop than asymptomatic individuals (75% vs. 32%, p < 0.01). Asymptomatic plaques had more quadrants with signal enhancement than symptomatic ones (68% vs. 25%, p < 0.05); their mean signal change was also higher (46% vs. 15%, p < 0.01) and this appeared to correlate with a thicker fibrous cap on histology. Conclusions: Symptomatic patients had more quadrants with signal drop suggesting larger inflammatory infiltrates. Asymptomatic individuals showed significantly more enhancement possibly suggesting greater stability as a result of thicker fibrous caps. However, some asymptomatic plaques also had focal areas of signal drop, suggesting an occult macrophage burden. If validated by larger studies, USPIO may be a useful dual contrast agent able to improve risk stratification of patients with carotid stenosis and inform selection for intervention.

  5. Utility of USPIO-enhanced MR imaging to identify inflammation and the fibrous cap: A comparison of symptomatic and asymptomatic individuals

    International Nuclear Information System (INIS)

    Howarth, S.P.S.; Tang, T.Y.; Trivedi, R.; Weerakkody, R.; U-King-Im, J.; Gaunt, M.E.; Boyle, J.R.; Li, Z.Y.; Miller, S.R.; Graves, M.J.; Gillard, J.H.

    2009-01-01

    Background and purpose: Inflammation is a risk factor the vulnerable atheromatous plaque. This can be detected in vivo on high-resolution magnetic resonance (MR) imaging using a contrast agent, Sinerem TM , an ultra-small super-paramagnetic iron oxide (USPIO). The aim of this study was to explore whether there is a difference in the degree of MR defined inflammation using USPIO particles, between symptomatic and asymptomatic carotid plaques. We report further on its T 1 effect of enhancing the fibrous cap, which may allow dual contrast resolution of carotid atheroma. Methods: Twenty patients with carotid stenosis (10 symptomatic and 10 asymptomatic) underwent multi-sequence MR imaging before and 36 h post-USPIO infusion. Images were manually segmented into quadrants and signal change in each quadrant was calculated following USPIO administration. Mean signal change across all quadrants were compared between the two groups. Results: Symptomatic patients had significantly more quadrants with a signal drop than asymptomatic individuals (75% vs. 32%, p < 0.01). Asymptomatic plaques had more quadrants with signal enhancement than symptomatic ones (68% vs. 25%, p < 0.05); their mean signal change was also higher (46% vs. 15%, p < 0.01) and this appeared to correlate with a thicker fibrous cap on histology. Conclusions: Symptomatic patients had more quadrants with signal drop suggesting larger inflammatory infiltrates. Asymptomatic individuals showed significantly more enhancement possibly suggesting greater stability as a result of thicker fibrous caps. However, some asymptomatic plaques also had focal areas of signal drop, suggesting an occult macrophage burden. If validated by larger studies, USPIO may be a useful dual contrast agent able to improve risk stratification of patients with carotid stenosis and inform selection for intervention.

  6. The Capability to Hold Property

    NARCIS (Netherlands)

    Claassen, Rutger

    2015-01-01

    This paper discusses the question of whether a capability theory of justice (such as that of Martha Nussbaum) should accept a basic “capability to hold property.” Answering this question is vital for bridging the gap between abstract capability theories of justice and their institutional

  7. Pervious concrete research facility : winter performance and enhancement of pollutants removal.

    Science.gov (United States)

    2013-12-01

    The purpose of the current study was to design and test a porous medium that can potentially be applied in : pervious pavement systems. The principle goals were to identify a material capable of enhancing the PAH : sorption capacity, thereby mitigati...

  8. Contingent Capability of a Conceived Child: Civil Law Aspect

    Science.gov (United States)

    Kirillova, Elena A.; Suslikov, Vladimir N.; Blinkova, Elena V.; Blinkov, Oleg E.; Staroseltseva, Marina M.

    2016-01-01

    This paper covers on contingent legal capability of a conceived child. To protect the capability of conceived children and legal rights, including property, emerging on that basis, it is imperative to strictly identify the moment of emergence and termination of legal capability. The objective of this research is to analyze the provisions on civil…

  9. Cosmopolitan capabilities in the HE classroom

    Directory of Open Access Journals (Sweden)

    Veronica Crosbie

    2014-04-01

    Full Text Available This study, concerning the development of cosmopolitan citizenship, draws on theories of human development and capabilities (Sen 1999; Nussbaum 2000 from a social justice perspective, where individual wellbeing is articulated as having the freedom to live a life of one’s choosing. In the context of an English to Speakers of Other Languages (ESOL classroom this involves paying attention to pedagogical strategies, power dynamics and curriculum content as a means of developing valued beings and doings (or capabilities and functionings as they are described in the literature. Sample activities are presented and evaluated to see to what extent they achieve the desired end. These include critical pedagogical interventions, students’ artefacts and extracts from focus group interviews, class reports and reflective journals.  Results from the textual data offer research evidence of successful curriculum change, demonstrating that the learning that takes place there can make a difference: in terms of the learners’ identity development, capability enhancement and cosmopolitan citizenship.

  10. Personality Assessment: A Competency-Capability Perspective.

    Science.gov (United States)

    Kaslow, Nadine J; Finklea, J Tyler; Chan, Ginny

    2018-01-01

    This article begins by reviewing the proficiency of personality assessment in the context of the competencies movement, which has dominated health service psychology in recent years. It examines the value of including a capability framework for advancing this proficiency and enhancing the quality of personality assessments, including Therapeutic Assessment (Finn & Tonsager, 1997 ), that include a personality assessment component. This hybrid competency-capability framework is used to set the stage for the conduct of personality assessments in a variety of contexts and for the optimal training of personality assessment. Future directions are offered in terms of ways psychologists can strengthen their social contract with the public and offer a broader array of personality assessments in more diverse contexts and by individuals who are both competent and capable.

  11. Developing an operational capabilities index of the emergency services sector.

    Energy Technology Data Exchange (ETDEWEB)

    Collins, M.J.; Eaton, L.K.; Shoemaker, Z.M.; Fisher, R.E.; Veselka, S.N.; Wallace, K.E.; Petit, F.D. (Decision and Information Sciences)

    2012-02-20

    capabilities of a jurisdiction to protect itself from, mitigate, respond to, and recover from a potential incident. On the basis of this metric, an interactive tool - the ESSCI Dashboard - can identify scenarios for enhancement that can be implemented, and it can identify the repercussions of these scenarios on the jurisdiction. It can assess the capabilities of law enforcement, fire fighting, search and rescue, emergency medical services, hazardous materials response, dispatch/911, and emergency management services in a given jurisdiction and it can help guide those who need to prioritize what limited resources should be used to improve these capabilities. Furthermore, this tool can be used to compare the level of capabilities of various jurisdictions that have similar socioeconomic characteristics. It can thus help DHS define how it can support risk reduction and community preparedness at a national level. This tool aligns directly with Presidential Policy Directive 8 by giving a jurisdiction a metric of its ESS's capabilities and by promoting an interactive approach for defining options to improve preparedness and to effectively respond to a disruptive event. It can be used in combination with other CI performance metrics developed at Argonne National Laboratory, such as the vulnerability index and the resilience index for assessing regional resilience.

  12. Capability-based computer systems

    CERN Document Server

    Levy, Henry M

    2014-01-01

    Capability-Based Computer Systems focuses on computer programs and their capabilities. The text first elaborates capability- and object-based system concepts, including capability-based systems, object-based approach, and summary. The book then describes early descriptor architectures and explains the Burroughs B5000, Rice University Computer, and Basic Language Machine. The text also focuses on early capability architectures. Dennis and Van Horn's Supervisor; CAL-TSS System; MIT PDP-1 Timesharing System; and Chicago Magic Number Machine are discussed. The book then describes Plessey System 25

  13. Identifying non-toxic doses of manganese for manganese-enhanced magnetic resonance imaging to map brain areas activated by operant behavior in trained rats.

    Science.gov (United States)

    Gálosi, Rita; Szalay, Csaba; Aradi, Mihály; Perlaki, Gábor; Pál, József; Steier, Roy; Lénárd, László; Karádi, Zoltán

    2017-04-01

    Manganese-enhanced magnetic resonance imaging (MEMRI) offers unique advantages such as studying brain activation in freely moving rats, but its usefulness has not been previously evaluated during operant behavior training. Manganese in a form of MnCl 2 , at a dose of 20mg/kg, was intraperitoneally infused. The administration was repeated and separated by 24h to reach the dose of 40mg/kg or 60mg/kg, respectively. Hepatotoxicity of the MnCl 2 was evaluated by determining serum aspartate aminotransferase, alanine aminotransferase, total bilirubin, albumin and protein levels. Neurological examination was also carried out. The animals were tested in visual cue discriminated operant task. Imaging was performed using a 3T clinical MR scanner. T1 values were determined before and after MnCl 2 administrations. Manganese-enhanced images of each animal were subtracted from their baseline images to calculate decrease in the T1 value (ΔT1) voxel by voxel. The subtracted T1 maps of trained animals performing visual cue discriminated operant task, and those of naive rats were compared. The dose of 60mg/kg MnCl 2 showed hepatotoxic effect, but even these animals did not exhibit neurological symptoms. The dose of 20 and 40mg/kg MnCl 2 increased the number of omissions and did not affect the accuracy of performing the visual cue discriminated operant task. Using the accumulated dose of 40mg/kg, voxels with a significant enhanced ΔT1 value were detected in the following brain areas of the visual cue discriminated operant behavior performed animals compared to those in the controls: the visual, somatosensory, motor and premotor cortices, the insula, cingulate, ectorhinal, entorhinal, perirhinal and piriform cortices, hippocampus, amygdala with amygdalohippocampal areas, dorsal striatum, nucleus accumbens core, substantia nigra, and retrorubral field. In conclusion, the MEMRI proved to be a reliable method to accomplish brain activity mapping in correlation with the operant behavior

  14. ANTECEDENTS OF CUSTOMER RELATIONSHIP MANAGEMENT CAPABILITIES

    Directory of Open Access Journals (Sweden)

    Tuleu Daniela

    2015-07-01

    Full Text Available Customer relationship management, as a process to manage customer relationship initiation, maintenance and termination to maximize the value of the relationship portfolio, is an evolving process. In recent years, the development of interactive technologies (social media have revolutionized the interaction between firms and their customers and between customers. The impact of technology on CRM is improving ways of collecting and processing customer information and transforming communication with customers. In the context of the development of social networks, the introduction of social media applications in customer relationship management activities bring important changes in this area. Thus, managers need to pay attention to the interaction management as an important process of CRM and enhance the customer relationship management capabilities. The study propose a conceptual research model of several antecedents of customer relationship managements capabilities and provide the linkage between this antecedents and CRM capabilities. First, following review of existing research literature related to customer relationship management, there are some conceptual clarification on customer relationship management. Second, are presented the working concepts: the adoption of interactive technologies, customer concept, customer empowerment, customer relationship orientation and customer-centric management system. Then, it is proposed the conceptual model and finally are presented conclusions, managerial implications, limitations and research directions. From a theoretical perspective, this paper highlights the importance of marketing actions at the individual customer level and reveal the impact of adoption by companies of interactive technologies so that organizations have the opportunity to engage in conversations with customers and respond in real time the requirements that they launched the online environment. Nowadays, customers feel empowered and play

  15. Transforming organizational capabilities in strategizing

    DEFF Research Database (Denmark)

    Jørgensen, Claus; Friis, Ole Uhrskov; Koch, Christian

    2014-01-01

    Offshored and networked enterprises are becoming an important if not leading organizational form and this development seriously challenges their organizational capabilities. More specifically, over the last years, SMEs have commenced entering these kinds of arrangements. As the organizational...... capabilities of SMEs are limited at the outset, even more emphasis is needed regarding the issues of developing relevant organizational capabilities. This paper aims at investigating how capabilities evolve during an offshoring process of more than 5 years in two Danish SMEs, i.e. not only short- but long......-term evolvements within the companies. We develop our framework of understanding organizational capabilities drawing on dynamic capability, relational capability and strategy as practice concepts, appreciating the performative aspects of developing new routines. Our two cases are taken from one author’s Ph...

  16. Plutonium Oxide Process Capability Work Plan

    Energy Technology Data Exchange (ETDEWEB)

    Meier, David E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Tingey, Joel M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2014-02-28

    Pacific Northwest National Laboratory (PNNL) has been tasked to develop a Pilot-scale Plutonium-oxide Processing Unit (P3U) providing a flexible capability to produce 200g (Pu basis) samples of plutonium oxide using different chemical processes for use in identifying and validating nuclear forensics signatures associated with plutonium production. Materials produced can also be used as exercise and reference materials.

  17. Fuel Fabrication Capability Research and Development Plan

    Energy Technology Data Exchange (ETDEWEB)

    Senor, David J.; Burkes, Douglas

    2013-06-28

    The purpose of this document is to provide a comprehensive review of the mission of the Fuel Fabrication Capability (FFC) within the Global Threat Reduction Initiative (GTRI) Convert Program, along with research and development (R&D) needs that have been identified as necessary to ensuring mission success. The design and fabrication of successful nuclear fuels must be closely linked endeavors.

  18. Industrial global brand leadership : a capabilities view

    NARCIS (Netherlands)

    Beverland, M.; Napoli, J.; Lindgreen, A.

    2007-01-01

    We examine the global branding programs of five New Zealand industrial firms and identify the salient components and capabilities underpinning these programs. The cases built their respective brand identities around adaptability to customer needs and the provision of a total solution. This identity

  19. Assessment of Mobile Accident Response Capability

    International Nuclear Information System (INIS)

    1983-03-01

    This report presents the results of a DOE-sponsored assessment of nuclear accident response resources. It identifies the mobile resources that could be required to respond to different types of nuclear accidents including major ones like TMI-2, identifies the resources currently available and makes recommendations for the design and construction of additional mobile accident response resources to supplement those already in existence. This project is referred to as the Mobile Accident Response Capability (MARC) program

  20. Impact of Personnel Capabilities on Organizational Innovation Capability

    DEFF Research Database (Denmark)

    Nielsen, Susanne Balslev; Momeni, Mostafa

    2016-01-01

    in this rapidly changing world. This research focuses on definition of the personnel aspect of innovation capability, and proposes a conceptual model based on the scientific articles of academic literature on organisations innovation capability. This paper includes an expert based validation in three rounds...... of the Delphi method. And for the purpose of a better appreciation of the relationship dominating the factors of the model, it has distributed the questionnaire to Iranian companies in the Food industry. This research proposed a direct relationship between Innovation Capability and the Personnel Capability...

  1. Quantumness-generating capability of quantum dynamics

    Science.gov (United States)

    Li, Nan; Luo, Shunlong; Mao, Yuanyuan

    2018-04-01

    We study quantumness-generating capability of quantum dynamics, where quantumness refers to the noncommutativity between the initial state and the evolving state. In terms of the commutator of the square roots of the initial state and the evolving state, we define a measure to quantify the quantumness-generating capability of quantum dynamics with respect to initial states. Quantumness-generating capability is absent in classical dynamics and hence is a fundamental characteristic of quantum dynamics. For qubit systems, we present an analytical form for this measure, by virtue of which we analyze several prototypical dynamics such as unitary dynamics, phase damping dynamics, amplitude damping dynamics, and random unitary dynamics (Pauli channels). Necessary and sufficient conditions for the monotonicity of quantumness-generating capability are also identified. Finally, we compare these conditions for the monotonicity of quantumness-generating capability with those for various Markovianities and illustrate that quantumness-generating capability and quantum Markovianity are closely related, although they capture different aspects of quantum dynamics.

  2. People Capability Maturity Model. SM.

    Science.gov (United States)

    1995-09-01

    tailored so it consumes less time and resources than a traditional software process assessment or CMU/SEI-95-MM-02 People Capability Maturity Model...improved reputation or customer loyalty. CMU/SEI-95-MM-02 People Capability Maturity Model ■ L5-17 Coaching Level 5: Optimizing Activity 1...Maturity Model CMU/SEI-95-MM-62 Carnegie-Mellon University Software Engineering Institute DTIC ELECTE OCT 2 7 1995 People Capability Maturity

  3. Enhancement of B-cell receptor signaling by a point mutation of adaptor protein 3BP2 identified in human inherited disease cherubism.

    Science.gov (United States)

    Ogi, Kazuhiro; Nakashima, Kenji; Chihara, Kazuyasu; Takeuchi, Kenji; Horiguchi, Tomoko; Fujieda, Shigeharu; Sada, Kiyonao

    2011-09-01

    Tyrosine phosphorylation of adaptor protein c-Abl-Src homology 3 (SH3) domain-binding protein-2 (3BP2, also referred to SH3BP2) positively regulates the B-cell antigen receptor (BCR)-mediated signal transduction, leading to the activation of nuclear factor of activated T cells (NFAT). Here we showed the effect of the proline to arginine substitution of 3BP2 in which is the most common mutation in patients with cherubism (P418R) on B-cell receptor signaling. Comparing to the wild type, overexpression of the mutant form of 3BP2 (3BP2-P416R, corresponding to P418R in human protein) enhanced BCR-mediated activation of NFAT. 3BP2-P416R increased the signaling complex formation with Syk, phospholipase C-γ2 (PLC-γ2), and Vav1. In contrast, 3BP2-P416R could not change the association with the negative regulator 14-3-3. Loss of the association mutant that was incapable to associate with 14-3-3 could not mimic BCR-mediated NFAT activation in Syk-deficient cells. Moreover, BCR-mediated phosphorylation of extracellular signal regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) was not affected by P416R mutation. These results showed that P416R mutation of 3BP2 causes the gain of function in B cells by increasing the interaction with specific signaling molecules. © 2011 The Authors. Journal compilation © 2011 by the Molecular Biology Society of Japan/Blackwell Publishing Ltd.

  4. Organizational capability in the public sector: \\ud a configurational approach

    OpenAIRE

    Andrews, Rhys William; Beynon, Malcolm James; McDermott, Aoife

    2015-01-01

    This paper brings together resource-based theory and contingency theory to analyse organizational capability in the public sector. Fuzzy-set Qualitative Comparative Analysis is used to identify configurations of organizational attributes (department size, structural complexity, agencification, personnel instability, use of temporary employees), associated with high and low organizational capability in UK central government departments. Findings identify a single core configuration of organiza...

  5. Enhanced tortuosity for electrolytes in microwave irradiated self-organized carbon-doped Ni/Co hydroxide nanocomposite electrodes with higher Ni/Co atomic ratio and rate capability for an asymmetric supercapacitor.

    Science.gov (United States)

    Kumar, Niraj; Kumar, Viresh; Panda, H S

    2017-11-03

    We demonstrate a green, facile and rapid microwave-mediated process for fabricating carbon black (CB) incorporated Ni/Co hydroxide porous nanocomposites and study the effect of various mass loading of CB on supercapacitor performance. The structure and interactions between CB and Ni/Co hydroxide are characterized by using x-ray diffraction, Fourier-transform infrared spectroscopy and x-ray photoelectron spectroscopy, which suggest the miniaturization of the single-phase Ni/Co hydroxide formation time. A morphology study reveals that the addition of CB into Ni/Co hydroxide develops a loose network structure with well-defined architectural pores. In addition, the nanocomposites demonstrate noticeable improvements in porosity and atomic ratio of Ni/Co with an increasing percentage of carbon, which results in a higher diffusion of electrolytes, and hence electrical conduction. The developed electrode materials exhibit a maximum specific capacitance value of 1526 Fg -1 at current density 1 Ag -1 with excellent cyclic stability (92% retention at 5000 cycles), energy density (76 Wh Kg -1 ), power density (250 W Kg -1 ) and rate capability. A solid state asymmetric supercapacitor device is fabricated and utilized to brighten a commercial LED effectively for validating real usage.

  6. Enhanced tortuosity for electrolytes in microwave irradiated self-organized carbon-doped Ni/Co hydroxide nanocomposite electrodes with higher Ni/Co atomic ratio and rate capability for an asymmetric supercapacitor

    Science.gov (United States)

    Kumar, Niraj; Kumar, Viresh; Panda, H. S.

    2017-11-01

    We demonstrate a green, facile and rapid microwave-mediated process for fabricating carbon black (CB) incorporated Ni/Co hydroxide porous nanocomposites and study the effect of various mass loading of CB on supercapacitor performance. The structure and interactions between CB and Ni/Co hydroxide are characterized by using x-ray diffraction, Fourier-transform infrared spectroscopy and x-ray photoelectron spectroscopy, which suggest the miniaturization of the single-phase Ni/Co hydroxide formation time. A morphology study reveals that the addition of CB into Ni/Co hydroxide develops a loose network structure with well-defined architectural pores. In addition, the nanocomposites demonstrate noticeable improvements in porosity and atomic ratio of Ni/Co with an increasing percentage of carbon, which results in a higher diffusion of electrolytes, and hence electrical conduction. The developed electrode materials exhibit a maximum specific capacitance value of 1526 Fg-1 at current density 1 Ag-1 with excellent cyclic stability (92% retention at 5000 cycles), energy density (76 Wh Kg-1), power density (250 W Kg-1) and rate capability. A solid state asymmetric supercapacitor device is fabricated and utilized to brighten a commercial LED effectively for validating real usage.

  7. Structural Characteristics of the Novel Polysaccharide FVPA1 from Winter Culinary-Medicinal Mushroom, Flammulina velutipes (Agaricomycetes), Capable of Enhancing Natural Killer Cell Activity against K562 Tumor Cells.

    Science.gov (United States)

    Jia, Wei; Feng, Jie; Zhang, Jing-Song; Lin, Chi-Chung; Wang, Wen-Han; Chen, Hong-Ge

    2017-01-01

    FVPA1, a novel polysaccharide, has been isolated from fruiting bodies of the culinary-medicinal mushroom Flammulina velutipes, a historically popular, widely cultivated and consumed functional food with an attractive taste, beneficial nutraceutical properties such as antitumor and immunomodulatory effects, and a number of essential biological activities. The average molecular weight was estimated to be ~1.8 × 104 Da based on high-performance size exclusion chromatography. Sugar analyses, methylation analyses, and 1H, 13C, and 2-dimensional nuclear magnetic resonance spectroscopy revealed the following structure of the repeating units of the FVPA1 polysaccharide Identification of this structure would conceivably lead to better understanding of the nutraceutical functions of this very important edible fungus. Bioactivity tests in vitro indicated that FVPA1 could significantly enhance natural killer cell activity against K562 tumor cells.

  8. Disturbances of ligand potency and enhanced degradation of the human glycine receptor at affected positions G160 and T162 originally identified in patients suffering from hyperekplexia

    Directory of Open Access Journals (Sweden)

    Sinem eAtak

    2015-12-01

    Full Text Available Ligand-binding of Cys-loop receptors is determined by N-terminal extracellular loop structures from the plus as well as from the minus side of two adjacent subunits in the pentameric receptor complex. An aromatic residue in loop B of the glycine receptor (GlyR undergoes direct interaction with the incoming ligand via cation-π interactions. Recently we showed that mutated residues in loop B identified from human patients suffering from hyperekplexia disturb ligand-binding. Here, we exchanged the affected human residues by amino acids found in related members of the Cys-loop receptor family to determine the effects of side chain volume for ion channel properties. GlyR variants were characterized in vitro following transfection into cell lines in order to analyze protein expression, trafficking, degradation and ion channel function. GlyR α1 G160 mutations significantly decrease glycine potency arguing for a positional effect on neighboring aromatic residues and consequently glycine-binding within the ligand-binding pocket. Disturbed glycinergic inhibition due to T162 α1 mutations is an additive effect of affected biogenesis and structural changes within the ligand-binding site. Protein trafficking from the ER towards ER-Golgi intermediate compartment, the secretory Golgi pathways and finally the cell surface is largely diminished, but still sufficient to deliver ion channels that are functional at least at high glycine concentrations. The majority of T162 mutant protein accumulates in the ER and is conducted to ER-associated proteasomal degradation. Hence, G160 is an important determinant during glycine binding. In contrast, T162 assigns primarily receptor biogenesis whereas exchanges in functionality are secondary effects thereof.

  9. Technological Dynamics and Social Capability

    DEFF Research Database (Denmark)

    Fagerberg, Jan; Feldman, Maryann; Srholec, Martin

    2014-01-01

    for the sample as a whole between 1998 and 2008. The results indicate that social capabilities, such as well-developed public knowledge infrastructure, an egalitarian distribution of income, a participatory democracy and prevalence of public safety condition the growth of technological capabilities. Possible...

  10. Developing Collaborative Product Development Capabilities

    DEFF Research Database (Denmark)

    Mahnke, Volker; Tran, Yen

    2012-01-01

    innovation strategies’. Our analyses suggest that developing such collaboration capabilities benefits from the search for complementary practices, the combination of learning styles, and the development of weak and strong ties. Results also underscore the crucial importance of co-evolution of multi......Collaborative product development capabilities support a company’s product innovation activities. In the context of the fast fashion sector, this paper examines the development of the product development capabilities (PDC) that align product development capabilities in a dual innovation context......, one, slow paced, where the firm is well established and the other, fast paced, which represents a new competitive arena in which the company competes. To understand the process associated with collaborative capability development, we studied three Scandinavian fashion companies pursuing ‘dual...

  11. Marketing Capability in Strategy Research

    DEFF Research Database (Denmark)

    Ritter, Thomas; Distel, Andreas Philipp

    Following the call for a demand-side perspective of strategic management (e.g., Priem et al., 2012), a firm’s marketing capability, i.e. its ability to interact with down-stream stakeholders, becomes a pivotal element in explaining a firm’s competitiveness. While marketing capability is recognized...... in the strategic management literature as an important driver of firm performance, our review of 86 articles reveals a lack of a generally accepted definition of marketing capability, a lack of a common conceptualization as well as differences in the measurement of marketing capability. In order to build a common...... ground for advancing marketing capability research and thus supporting the demand-side perspective in strategic management, we develop an integrative framework to explain the differences and propose a research agenda for developing the field....

  12. A Dehydration-Induced Eukaryotic Translation Initiation Factor iso4G Identified in a Slow Wilting Soybean Cultivar Enhances Abiotic Stress Tolerance in Arabidopsis

    Directory of Open Access Journals (Sweden)

    Juan P. Gallino

    2018-03-01

    Full Text Available Water is usually the main limiting factor for soybean productivity worldwide and yet advances in genetic improvement for drought resistance in this crop are still limited. In the present study, we investigated the physiological and molecular responses to drought in two soybean contrasting genotypes, a slow wilting N7001 and a drought sensitive TJS2049 cultivars. Measurements of stomatal conductance, carbon isotope ratios and accumulated dry matter showed that N7001 responds to drought by employing mechanisms resulting in a more efficient water use than TJS2049. To provide an insight into the molecular mechanisms that these cultivars employ to deal with water stress, their early and late transcriptional responses to drought were analyzed by suppression subtractive hybridization. A number of differentially regulated genes from N7001 were identified and their expression pattern was compared between in this genotype and TJS2049. Overall, the data set indicated that N7001 responds to drought earlier than TJ2049 by up-regulating a larger number of genes, most of them encoding proteins with regulatory and signaling functions. The data supports the idea that at least some of the phenotypic differences between slow wilting and drought sensitive plants may rely on the regulation of the level and timing of expression of specific genes. One of the genes that exhibited a marked N7001-specific drought induction profile encoded a eukaryotic translation initiation factor iso4G (GmeIFiso4G-1a. GmeIFiso4G-1a is one of four members of this protein family in soybean, all of them sharing high sequence identity with each other. In silico analysis of GmeIFiso4G-1 promoter sequences suggested a possible functional specialization between distinct family members, which can attain differences at the transcriptional level. Conditional overexpression of GmeIFiso4G-1a in Arabidopsis conferred the transgenic plants increased tolerance to osmotic, salt, drought and low

  13. Capabilities and Incapabilities of the Capabilities Approach to Health Justice.

    Science.gov (United States)

    Selgelid, Michael J

    2016-01-01

    This first part of this article critiques Sridhar Venkatapuram's conception of health as a capability. It argues that Venkatapuram relies on the problematic concept of dignity, implies that those who are unhealthy lack lives worthy of dignity (which seems politically incorrect), sets a low bar for health, appeals to metaphysically problematic thresholds, fails to draw clear connections between appealed-to capabilities and health, and downplays the importance/relevance of health functioning. It concludes by questioning whether justice entitlements should pertain to the capability for health versus health achievements, challenging Venkatapuram's claims about the strength of health entitlements, and demonstrating that the capabilities approach is unnecessary to address social determinants of health. © 2016 John Wiley & Sons Ltd.

  14. Determination of Innovation Capability of Organizations: Qualitative Meta Synthesis and Delphi Method

    DEFF Research Database (Denmark)

    Momeni, Mostafa; Nielsen, Susanne Balslev; Kafash, Mahdi Haghighi

    2015-01-01

    . The innovation capability is associated with other organizational capabilities. So, many organizations have focused on the need to identify innovation capabilities and resources or strengths in relation to external opportunities and threats according to inside-out view because innovation capability has...... capability in the organizations and this paper includes an expert based validation in three rounds of the Delphi method. This research proposed a direct relationship between Innovation Capability and three main capabilities that is called Structural Capability, Personnel Capability and Operational Capability...

  15. Computable general equilibrium model fiscal year 2014 capability development report

    Energy Technology Data Exchange (ETDEWEB)

    Edwards, Brian Keith [Los Alamos National Laboratory; Boero, Riccardo [Los Alamos National Laboratory

    2016-05-11

    This report provides an overview of the development of the NISAC CGE economic modeling capability since 2012. This capability enhances NISAC's economic modeling and analysis capabilities to answer a broader set of questions than possible with previous economic analysis capability. In particular, CGE modeling captures how the different sectors of the economy, for example, households, businesses, government, etc., interact to allocate resources in an economy and this approach captures these interactions when it is used to estimate the economic impacts of the kinds of events NISAC often analyzes.

  16. Capable design or designing capabilities? An exploration of service design as an emerging organizational capability in Telenor – Martinkenaite

    Directory of Open Access Journals (Sweden)

    Ieva Martinkenaite

    2017-01-01

    Full Text Available This empirical paper examines a process, starting with the managerial decision to make service design an organizational capability, and follows it as it unfolds over time within one organization. Service design has become an established business practice of how firms create new products and services to promote differentiation in an increasingly uncertain business landscape. Implicit in the literature on service design are assumptions about strategic implications of adopting the prescribed innovation methods and tools. However, little is known about how service design evolves into an organizational capability enabling firms to transform their existing businesses and sustain competitiveness. Through a longitudinal, exploratory case study of service design practices in one of the world’s largest telecommunications companies, we explicate mechanisms through which service design evolves into an organizational capability by exploring the research question: what are the mechanisms through which service design develops into an organizational capability? Our study reveals the effect of an initial introduction of service design tools, identification of boundaryspanning actors and co-alignment of dedicated resources between internal functions, as well as through co-creation with customers. Over time, these activities lead to the adoption of service design practices, and subsequently these practices spark incremental learning throughout the organization, alter managerial decisions and influence multiple paths for the development of new capabilities. Reporting on this process, we are able to describe how service design practices were disseminated and institutionalized within the organization we observed. This study thus contributes by informing how service design can evolve into an organizational capability, as well as by bridging the emerging literature on service design and design thinking with established strategy theory. Further research will have to

  17. Indigenous Technological Innovation : Capability and ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Indigenous Technological Innovation : Capability and Competitiveness in China's ... IDRC and key partners will showcase critical work on adaptation and ... Call for new OWSD Fellowships for Early Career Women Scientists now open.

  18. Earth Science Capability Demonstration Project

    Science.gov (United States)

    Cobleigh, Brent

    2006-01-01

    A viewgraph presentation reviewing the Earth Science Capability Demonstration Project is shown. The contents include: 1) ESCD Project; 2) Available Flight Assets; 3) Ikhana Procurement; 4) GCS Layout; 5) Baseline Predator B Architecture; 6) Ikhana Architecture; 7) UAV Capability Assessment; 8) The Big Picture; 9) NASA/NOAA UAV Demo (5/05 to 9/05); 10) NASA/USFS Western States Fire Mission (8/06); and 11) Suborbital Telepresence.

  19. Information Management in Creative Engineering Design and Capabilities of Database Transactions

    DEFF Research Database (Denmark)

    Jacobsen, Kim; Eastman, C. A.; Jeng, T. S.

    1997-01-01

    This paper examines the information management requirements and sets forth the general criteria for collaboration and concurrency control in creative engineering design. Our work attempts to recognize the full range of concurrency, collaboration and complex transactions structure now practiced...... in manual and semi-automated design and the range of capabilities needed as the demands for enhanced but flexible electronic information management unfolds.The objective of this paper is to identify new issues that may advance the use of databases to support creative engineering design. We start...... with a generalized description of the structure of design tasks and how information management in design is dealt with today. After this review, we identify extensions to current information management capabilities that have been realized and/or proposed to support/augment what designers can do now. Given...

  20. Materials capability review Los Alamos National Laboratory, May 3-6, 2010

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, Antoinette [Los Alamos National Laboratory

    2010-01-01

    The 2010 'Capability Review' process at LANL significantly differs from the Division reviews of prior years. The Capabilities being reviewed (some 4-8 per year) are deliberately chosen to be crosscutting over the Laboratory, and therefore will include not only several experimental, theoretical and simulation disciplines, but also contributions from multiple line organizations. This approach is consistent with the new Laboratory organizational structure, focusing on agile and integrated capabilities applied to present national security missions, and also nurtured to be available for rapid application to future missions. The overall intent is that the Committee assess the quality of the science, engineering, and technology identified in the agenda, and advise the LANS Board of Governors and Laboratory management. Specifically, the Committees will: (1) Assess the quality of science, technology and engineering within the Capability in the areas defined in the agenda. Identify issues to develop or enhance the core competencies within this capability. (2) Evaluate the integration of this capability across the Laboratory organizations that are listed in the agenda in terms of joint programs, projects, proposals, and/or publications. Describe the integration of this capability in the wider scientific community using the recognition as a leader within the community, ability to set research agendas, and attraction and retention of staff. (3) Assess the quality and relevance of this capability's science, technology and engineering contributions to current and emerging Laboratory programs, including Nuclear Weapons, Threat Reduction/Homeland Security, and Energy Security. (4) Advise the Laboratory Director/Principal Associate Director for Science, Technology and Engineering on the health of the Capability including the current and future (5 year) science, technology and engineering staff needs, mix of research and development activities, program opportunities

  1. Understanding the origin of radon indoors: Building a predictive capability

    International Nuclear Information System (INIS)

    Sextro, R.G.

    1985-12-01

    Indoor radon concentrations one to two orders of magnitude higher than the US average of ∼60 Bq m -3 (∼1.5 pCi L -1 ) are not uncommon, and concentrations greater than 4000 Bq m -3 have been observed in houses in areas with no known artificially-enhanced radon sources. In general, source categories for indoor radon are well known: soil, domestic water, building materials, outdoor air, and natural gas. Soil is thought to be a major source of indoor radon, either through molecular diffusion (usually a minor component) or convective flow of soil gas. While soil gas flow into residences has been demonstrated, no detailed understanding of the important factors affecting the source strength of radon from soil has yet emerged. Preliminary work in this area has identified a number of likely issues, including the concentration of radium in the soil, the emanating fraction, soil type, soil moisture content, and other factors that would influence soil permeability and soil gas transport. Because a significant number of dwellings are expected to have indoor radon concentrations above guideline levels, a predictive capability is needed that would help identify geographical areas having the potential for high indoor concentrations. This paper reviews the preliminary work that has been done to identify important soil and building characteristics that influence the migration of radon and outlines the areas of further research necessary for development of a predictive method. 32 refs., 4 figs

  2. Applying systems engineering principles towards developing defence capabilities

    CSIR Research Space (South Africa)

    Smith, CJ

    2011-09-01

    Full Text Available responsibility is creating and executing an interdisciplinary process to ensure that the customer and stakeholders? needs are satisfied in a high quality, trustworthy, cost efficient and schedule compliant manner throughout a system?s entire life cycle... in the As-Is J Ops capability arising from factors such as changes in the operational environment (threat, theatres of operation, etc.), new technology insertion and obsolescence can be identified. These capability gaps are analysed in the Capability...

  3. RIA testing capability of the transient reactor test facility

    International Nuclear Information System (INIS)

    Crawford, D.C.; Swanson, R.W.

    1999-01-01

    The advent of high-burnup fuel implementation in LWRs has generated international interest in high-burnup LWR fuel performance. Recent testing under simulated RIA conditions has demonstrated that certain fuel designs fail at peak fuel enthalpy values that are below existing regulatory criteria. Because many of these tests were performed with non-prototypically aggressive test conditions (i.e., with power pulse widths less than 10 msec FWHM and with non-protoypic coolant configurations), the results (although very informative) do not indisputably identify failure thresholds and fuel behavior. The capability of the TREAT facility to perform simulated RIA tests with prototypic test conditions is currently being evaluated by ANL personnel. TREAT was designed to accommodate test loops and vehicles installed for in-pile transient testing. During 40 years of TREAT operation and fuel testing and evaluation, experimenters have been able to demonstrate and determine the transient behavior of several types of fuel under a variety of test conditions. This experience led to an evolution of test methodology and techniques which can be employed to assess RIA behavior of LWR fuel. A pressurized water loop that will accommodate RIA testing of LWR and CANDU-type fuel has completed conceptual design. Preliminary calculations of transient characteristics and energy deposition into test rods during hypothetical TREAT RIA tests indicate that with the installation of a pressurized water loop, the facility is quite capable of performing prototypic RIA testing. Typical test scenarios indicate that a simulated RIA with a 72 msec FWHM pulse width and energy deposition of 1200 kJ/kg (290 cal/gm) is possible. Further control system enhancements would expand the capability to pulse widths as narrow as 40 msec. (author)

  4. Food product tracing technology capabilities and interoperability.

    Science.gov (United States)

    Bhatt, Tejas; Zhang, Jianrong Janet

    2013-12-01

    demonstration of interoperability enables U.S. FDA to obtain evidence on the importance and impact of data-sharing moving forward. Another real-world accomplishment is the modification or upgrade of commercial technology solutions to enhance or implement interoperability. As these systems get deployed by clients in the food industry, interoperability will no longer be an afterthought but will be built into their traceability systems. In turn, industry and regulators will better understand the capabilities of the currently available technologies, and the technology provider community will identify ways in which their systems may be further developed to increase interoperability and utility. © 2013 Institute of Food Technologists®

  5. Technological Capability and Firm Performance

    Directory of Open Access Journals (Sweden)

    Fernanda Maciel Reichert

    2014-08-01

    Full Text Available This research aims to investigate the relationship between investments in technological capability and economic performance in Brazilian firms. Based on economic development theory and on developed countries history, it is assumed that this relationship is positive. Through key indicators, 133 Brazilian firms have been analyzed. Given the economic circumstances of an emerging economy, which the majority of businesses are primarily based on low and medium-low-technology industries, it is not possible to affirm the existence of a positive relation between technological capability and firm performance. There are other elements that allow firms to achieve such results. Firms of lower technological intensity industries performed above average in the economic performance indicators, adversely, they invested below average in technological capability. These findings do not diminish the merit of firms’ and country’s success. They in fact confirm a historical tradition of a country that concentrates its efforts on basic industries.

  6. Functional capability of piping systems

    International Nuclear Information System (INIS)

    Terao, D.; Rodabaugh, E.C.

    1992-11-01

    General Design Criterion I of Appendix A to Part 50 of Title 10 of the Code of Federal Regulations requires, in part, that structures, systems, and components important to safety be designed to withstand the effects of earthquakes without a loss of capability to perform their safety function. ne function of a piping system is to convey fluids from one location to another. The functional capability of a piping system might be lost if, for example, the cross-sectional flow area of the pipe were deformed to such an extent that the required flow through the pipe would be restricted. The objective of this report is to examine the present rules in the American Society of Mechanical Engineers Boiler and Pressure Vessel Code, Section III, and potential changes to these rules, to determine if they are adequate for ensuring the functional capability of safety-related piping systems in nuclear power plants

  7. Capabilities for managing service innovation: towards a conceptual framework

    NARCIS (Netherlands)

    den Hertog, P.; van der Aa, W.; de Jong, M.W.

    2010-01-01

    Purpose - The purpose of this paper is to identify and reflect on a set of dynamic capabilities for managing service innovation and applies a dynamic capabilities view (DCV) of firms for managing service innovation. Design/methodology/approach - This theoretical paper offers a conceptual framework

  8. Defining Medical Capabilities for Exploration Missions

    Science.gov (United States)

    Hailey, M.; Antonsen, E.; Blue, R.; Reyes, D.; Mulcahy, R.; Kerstman, E.; Bayuse, T.

    2018-01-01

    Exploration-class missions to the moon, Mars and beyond will require a significant change in medical capability from today's low earth orbit centric paradigm. Significant increases in autonomy will be required due to differences in duration, distance and orbital mechanics. Aerospace medicine and systems engineering teams are working together within ExMC to meet these challenges. Identifying exploration medical system needs requires accounting for planned and unplanned medical care as defined in the concept of operations. In 2017, the ExMC Clinicians group identified medical capabilities to feed into the Systems Engineering process, including: determining what and how to address planned and preventive medical care; defining an Accepted Medical Condition List (AMCL) of conditions that may occur and a subset of those that can be treated effectively within the exploration environment; and listing the medical capabilities needed to treat those conditions in the AMCL. This presentation will discuss the team's approach to addressing these issues, as well as how the outputs of the clinical process impact the systems engineering effort.

  9. Nanofabrication principles, capabilities and limits

    CERN Document Server

    Cui, Zheng

    2017-01-01

    This second edition of Nanofabrication is one of the most comprehensive introductions on nanofabrication technologies and processes. A practical guide and reference, this book introduces readers to all of the developed technologies that are capable of making structures below 100nm. The principle of each technology is introduced and illustrated with minimum mathematics involved. Also analyzed are the capabilities of each technology in making sub-100nm structures, and the limits of preventing a technology from going further down the dimensional scale. This book provides readers with a toolkit that will help with any of their nanofabrication challenges.

  10. Judgmental Forecasting of Operational Capabilities

    DEFF Research Database (Denmark)

    Hallin, Carina Antonia; Tveterås, Sigbjørn; Andersen, Torben Juul

    This paper explores a new judgmental forecasting indicator, the Employee Sensed Operational Capabilities (ESOC). The purpose of the ESOC is to establish a practical prediction tool that can provide early signals about changes in financial performance by gauging frontline employees’ sensing...... of changes in the firm’s operational capabilities. We present the first stage of the development of ESOC by applying a formative measurement approach to test the index in relation to financial performance and against an organizational commitment scale. We use distributed lag models to test whether the ESOC...

  11. Competencies, Capabilities and the Neoschumpeterian Tradition

    DEFF Research Database (Denmark)

    Augier, Mie-Sophia; Teece, David J.

    2004-01-01

    In this paper, Mie Augier and David Teece outline the history and development of the ideas underlying an emerging approach within strategic management research: the dynamic capabili-ties framework. The framework was first outlined by Teece and Pisano (1994), and in the pre-sent paper elaborated...... theory of the firm) and Nelson and Winter (an evolutionary theory of economic change). In the dynamic capability framework firms and markets co-evolve. Managers are now allowed to perform distinct strate-gic roles in shaping both firms and their markets, e.g. through asset- selection and orchestra...... into a topic for further discussion. For example, Augier and Teece identify not only the merits but also the limitations of transaction costs eco-nomics. In this way, the authors pave the way for a more dynamic framework while drawing upon organization theory and scholars like Cyert and March (a behavioral...

  12. Satellite-based Tropical Cyclone Monitoring Capabilities

    Science.gov (United States)

    Hawkins, J.; Richardson, K.; Surratt, M.; Yang, S.; Lee, T. F.; Sampson, C. R.; Solbrig, J.; Kuciauskas, A. P.; Miller, S. D.; Kent, J.

    2012-12-01

    Satellite remote sensing capabilities to monitor tropical cyclone (TC) location, structure, and intensity have evolved by utilizing a combination of operational and research and development (R&D) sensors. The microwave imagers from the operational Defense Meteorological Satellite Program [Special Sensor Microwave/Imager (SSM/I) and the Special Sensor Microwave Imager Sounder (SSMIS)] form the "base" for structure observations due to their ability to view through upper-level clouds, modest size swaths and ability to capture most storm structure features. The NASA TRMM microwave imager and precipitation radar continue their 15+ yearlong missions in serving the TC warning and research communities. The cessation of NASA's QuikSCAT satellite after more than a decade of service is sorely missed, but India's OceanSat-2 scatterometer is now providing crucial ocean surface wind vectors in addition to the Navy's WindSat ocean surface wind vector retrievals. Another Advanced Scatterometer (ASCAT) onboard EUMETSAT's MetOp-2 satellite is slated for launch soon. Passive microwave imagery has received a much needed boost with the launch of the French/Indian Megha Tropiques imager in September 2011, basically greatly supplementing the very successful NASA TRMM pathfinder with a larger swath and more frequent temporal sampling. While initial data issues have delayed data utilization, current news indicates this data will be available in 2013. Future NASA Global Precipitation Mission (GPM) sensors starting in 2014 will provide enhanced capabilities. Also, the inclusion of the new microwave sounder data from the NPP ATMS (Oct 2011) will assist in mapping TC convective structures. The National Polar orbiting Partnership (NPP) program's VIIRS sensor includes a day night band (DNB) with the capability to view TC cloud structure at night when sufficient lunar illumination exits. Examples highlighting this new capability will be discussed in concert with additional data fusion efforts.

  13. Building server capabilities in China

    DEFF Research Database (Denmark)

    Adeyemi, Oluseyi; Slepniov, Dmitrij; Wæhrens, Brian Vejrum

    2012-01-01

    The purpose of this paper is to further our understanding of multinational companies building server capabilities in China. The paper is based on the cases of two western companies with operations in China. The findings highlight a number of common patterns in the 1) managerial challenges related...

  14. Capability and Learning to Choose

    Science.gov (United States)

    LeBmann, Ortrud

    2009-01-01

    The Capability Approach (henceforth CA) is in the first place an approach to the evaluation of individual well-being and social welfare. Many disciplines refer to the CA, first and foremost welfare economics, development studies and political philosophy. Educational theory was not among the first disciplines that took notice of the CA, but has a…

  15. Mobile Smog Simulator: New Capabilities to Study Urban Mixtures

    Science.gov (United States)

    A smog simulator developed by EPA scientists and engineers has unique capabilities that will provide information for assessing the health impacts of relevant multipollutant atmospheres and identify contributions of specific sources.

  16. Exploring the resource and capabilities of food related enterprises in ...

    African Journals Online (AJOL)

    Agribotix GCS 068

    Specifically, the two case studies illustrate the capabilities of business owners to identify assets at their ...... Strategic management and competitive advantage: Concepts .... Journal of Contemporary Hospitality Management 8(6), 427-436.

  17. Fused Reality for Enhanced Flight Test Capabilities, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — While modern ground-based flight simulators continue to improve in fidelity and effectiveness, there remains no substitute for flight test evaluations. In addition...

  18. Fused Reality for Enhanced Flight Test Capabilities, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — In terms of relevancy to piloted evaluation, there remains no substitute for actual flight tests even when considering the fidelity and effectiveness of modern...

  19. Enhancing Docking and Manipulation Capability for Microgravity Robotic Free Flyers

    Data.gov (United States)

    National Aeronautics and Space Administration — The risks and challenges of the space environment have logically led to proposals to use robots to perform tasks for efficiency and safety reasons. Robotic free...

  20. Enhancing Capability for Cognitive Neuroscience Research at UNLV

    Science.gov (United States)

    2017-10-31

    coils on head at one time for connectivity studies) • 2 large size Deymed TMS coils (useful for stimulating deeper structures such as leg portion of...size Deymed TMS coils (useful for stimulating a single brain area) • 4 small size Deymed TMS coils (useful for placing 2 coils on head at one time for...estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the

  1. Commonwealth Edison's approach to enhanced on-shift technical capability

    International Nuclear Information System (INIS)

    Toscas, J.G.

    1981-01-01

    A long-term plan was formulated that called for the integration of accident assessment and operational supervisory functions into a new operating position called the Station Control Room Engineer (SCRE). Pending implementation of the long-term plan, an alternative to the Shift Technical Advisor concept was selected as an interim plan. This alternative, called the SRO Augmentation program, involved giving five modules of specialized training to shift Senior Operators

  2. Tracked Robot with Blade Arms to Enhance Crawling Capability

    OpenAIRE

    Jhu-Wei Ji; Fa-Shian Chang; Lih-Tyng Hwang; Chih-Feng Liu; Jeng-Nan Lee; Shun-Min Wang; Kai-Yi Cho

    2016-01-01

    This paper presents a tracked robot with blade arms powered to assist movement in difficult environments. As a result, the tracked robot is able to pass a ramp or climb stairs. The main feature is a pair of blade arms on both sides of the vehicle body working in collaboration with previously validated transformable track system. When the robot encounters an obstacle in a terrain, it enlists the blade arms with power to overcome the obstacle. In disaster areas, there usually will be terrains t...

  3. Patriot Advanced Capability-3 Missile Segment Enhancement (PAC-3 MSE)

    Science.gov (United States)

    2015-12-01

    Patriot Conduct of Fire Trainer PoP - Proof of Principle T - Threshold TADiL-J - Tactical Digital Information Link-Joint TADSS - Training Aids, Devices...Production Estimate Econ Qty Sch Eng Est Oth Spt Total 5.272 0.311 0.411 0.398 0.000 0.126 0.000 -0.158 1.088 6.360 Current SAR Baseline to Current...Development Estimate Changes APUC Production Estimate Econ Qty Sch Eng Est Oth Spt Total 4.957 0.287 0.286 0.398 0.000 -0.244 0.000 -0.158 0.569 5.526

  4. A database system for enhancing fuel records management capabilities

    International Nuclear Information System (INIS)

    Rieke, Phil; Razvi, Junaid

    1994-01-01

    The need to modernize the system of managing a large variety of fuel related data at the TRIGA Reactors Facility at General Atomics, as well as the need to improve NRC nuclear material reporting requirements, prompted the development of a database to cover all aspects of fuel records management. The TRIGA Fuel Database replaces (a) an index card system used for recording fuel movements, (b) hand calculations for uranium burnup, and (c) a somewhat aged and cumbersome system of recording fuel inspection results. It was developed using Microsoft Access, a relational database system for Windows. Instead of relying on various sources for element information, users may now review individual element statistics, record inspection results, calculate element burnup and more, all from within a single application. Taking full advantage of the ease-of-use features designed in to Windows and Access, the user can enter and extract information easily through a number of customized on screen forms, with a wide variety of reporting options available. All forms are accessed through a main 'Options' screen, with the options broken down by categories, including 'Elements', 'Special Elements/Devices', 'Control Rods' and 'Areas'. Relational integrity and data validation rules are enforced to assist in ensuring accurate and meaningful data is entered. Among other items, the database lets the user define: element types (such as FLIP or standard) and subtypes (such as fuel follower, instrumented, etc.), various inspection codes for standardizing inspection results, areas within the facility where elements are located, and the power factors associated with element positions within a reactor. Using fuel moves, power history, power factors and element types, the database tracks uranium burnup and plutonium buildup on a quarterly basis. The Fuel Database was designed with end-users in mind and does not force an operations oriented user to learn any programming or relational database theory in order to take advantage of the information it contains. (author)

  5. Enhanced H- ion source testing capabilities at LANSCE

    International Nuclear Information System (INIS)

    Ingalls, W.B.; Hardy, M.W.; Prichard, B.A.; Sander, O.R.; Stelzer, J.E.; Stevens, R.R.; Leung, K.N.; Williams, M.D.

    1998-01-01

    As part of the on-going beam-current upgrade in the Proton Storage Ring (PSR) at the Los Alamos Neutron Science Center (LANSCE), the current available from the H - injector will be increased from the present 16 to 18 mA to as much as 40 mA. A collaboration between the Ion Beam Technology Group at Lawrence Berkeley National Laboratory (LBNL) and the Ion Sources and Injectors section of LANSCE-2 at Los Alamos National Laboratory (LANL) has been formed to develop and evaluate a new ion source. A new Ion Source Test Stand (ISTS) has been constructed at LANSCE to evaluate candidate ion sources. The ISTS has been constructed to duplicate as closely as possible the beam transport and ancillary systems presently in use in the LANSCE H - injector, while incorporating additional beam diagnostics for source testing. The construction and commissioning of the ISTS will be described, preliminary results for the proof-of-principle ion source developed by the Berkeley group will be presented, and future plans for the extension of the test stand will be presented

  6. International Biodefense Enhancement Capabilities from a Policy Perspective

    Science.gov (United States)

    2005-05-01

    Ministerio de Justicia, Seguridad y Derechos Humanos - Secretaria de Seguridad Interior. Descrpdci6n de los Comitis Comit6 de Inundaciones Comit6 de...esfuerzo conjunto de Fundaci6n ERA DIGITAL y CiMeRC con la Organizaci6n Panamericana de la Salud y el Ministerio de Justicia, Seguridad y Derechos ... Humanos se intentard realizar la adaptaci6n cultural, social y politica de estas herramientas para la Argentina, complementando con sus contenidos aquellos

  7. Los Alamos neutral particle transport codes: New and enhanced capabilities

    International Nuclear Information System (INIS)

    Alcouffe, R.E.; Baker, R.S.; Brinkley, F.W.; Clark, B.A.; Koch, K.R.; Marr, D.R.

    1992-01-01

    We present new developments in Los Alamos discrete-ordinates transport codes and introduce THREEDANT, the latest in the series of Los Alamos discrete ordinates transport codes. THREEDANT solves the multigroup, neutral-particle transport equation in X-Y-Z and R-Θ-Z geometries. THREEDANT uses computationally efficient algorithms: Diffusion Synthetic Acceleration (DSA) is used to accelerate the convergence of transport iterations, the DSA solution is accelerated using the multigrid technique. THREEDANT runs on a wide range of computers, from scientific workstations to CRAY supercomputers. The algorithms are highly vectorized on CRAY computers. Recently, the THREEDANT transport algorithm was implemented on the massively parallel CM-2 computer, with performance that is comparable to a single-processor CRAY-YMP We present the results of THREEDANT analysis of test problems

  8. Social policies related to parenthood and capabilities of Slovenian parents.

    Science.gov (United States)

    Mrčela, Aleksandra Kanjuo; Sadar, Nevenka Černigoj

    2011-01-01

    We apply Sen's capability approach to evaluate the capabilities of Slovenian parents to reconcile paid work and family in the context of the transition to a market economy. We examine how different levels of capabilities together affect the work–life balance (WLB) of employed parents. We combine both quantitative and qualitative methodological approaches. The results of our quantitative and qualitative research show that increased precariousness of employment and intensification of work create gaps between the legal and normative possibilities for successful reconciliation strategies and actual use of such arrangements in Slovenia. The existing social policies and the acceptance of gender equality in the sphere of paid work enhance capabilities for reconciliation of paid work and parenthood, whereas the intensification of working lives, the dominance of paid work over other parts of life, and the acceptance of gender inequalities in parental and household responsibilities limit parents’ capabilities to achieve WLB.

  9. Evolving Capabilities for Virtual Globes

    Science.gov (United States)

    Glennon, A.

    2006-12-01

    Though thin-client spatial visualization software like Google Earth and NASA World Wind enjoy widespread popularity, a common criticism is their general lack of analytical functionality. This concern, however, is rapidly being addressed; standard and advanced geographic information system (GIS) capabilities are being developed for virtual globes--though not centralized into a single implementation or software package. The innovation is mostly originating from the user community. Three such capabilities relevant to the earth science, education, and emergency management communities are modeling dynamic spatial phenomena, real-time data collection and visualization, and multi-input collaborative databases. Modeling dynamic spatial phenomena has been facilitated through joining virtual globe geometry definitions--like KML--to relational databases. Real-time data collection uses short scripts to transform user-contributed data into a format usable by virtual globe software. Similarly, collaborative data collection for virtual globes has become possible by dynamically referencing online, multi-person spreadsheets. Examples of these functions include mapping flows within a karst watershed, real-time disaster assessment and visualization, and a collaborative geyser eruption spatial decision support system. Virtual globe applications will continue to evolve further analytical capabilities, more temporal data handling, and from nano to intergalactic scales. This progression opens education and research avenues in all scientific disciplines.

  10. Experimental modeling of eddy current inspection capabilities

    International Nuclear Information System (INIS)

    Junker, W.R.; Clark, W.G.

    1984-01-01

    This chapter examines the experimental modeling of eddy current inspection capabilities based upon the use of liquid mercury samples designed to represent metal components containing discontinuities. A brief summary of past work with mercury modeling and a detailed discussion of recent experiments designed to further evaluate the technique are presented. The main disadvantages of the mercury modeling concept are that mercury is toxic and must be handled carefully, liquid mercury can only be used to represent nonferromagnetic materials, and wetting and meniscus problems can distort the effective size of artificial discontinuities. Artificial discontinuities placed in a liquid mercury sample can be used to represent discontinuities in solid metallic structures. Discontinuity size and type cannot be characterized from phase angle and signal amplitude data developed with a surface scanning, pancake-type eddy current probe. It is concluded that the mercury model approach can greatly enhance the overall understanding and applicability of eddy current inspection techniques

  11. Unpacking dynamic capability : a design perspective

    NARCIS (Netherlands)

    Mulders, D.E.M.; Romme, A.G.L.; Bøllingtoft, A.; Håkonsson, D.D.; Nielsen, J.F.; Snow, C.C; Ulhøi, J.

    2009-01-01

    This chapter reviews the dynamic capability literature to explore relationships between definition, operationalization, and measurement of dynamic capability. Subsequently, we develop a design-oriented approach toward dynamic capability that distinguishes between design rules, recurrent patterns of

  12. Summary of Sandia Laboratories technical capabilities

    International Nuclear Information System (INIS)

    1977-05-01

    The technical capabilities of Sandia Laboratories are detailed in a series of companion reports. In this summary the use of the capabilities in technical programs is outlined and the capabilities are summarized. 25 figures, 3 tables

  13. The Greater Sekhukhune-CAPABILITY outreach project.

    Science.gov (United States)

    Gregersen, Nerine; Lampret, Julie; Lane, Tony; Christianson, Arnold

    2013-07-01

    The Greater Sekhukhune-CAPABILITY Outreach Project was undertaken in a rural district in Limpopo, South Africa, as part of the European Union-funded CAPABILITY programme to investigate approaches for capacity building for the translation of genetic knowledge into care and prevention of congenital disorders. Based on previous experience of a clinical genetic outreach programme in Limpopo, it aimed to initiate a district clinical genetic service in Greater Sekhukhune to gain knowledge and experience to assist in the implementation and development of medical genetic services in South Africa. Implementing the service in Greater Sekhukhune was impeded by a developing staff shortage in the province and pressure on the health service from the existing HIV/AIDS and TB epidemics. This situation underscores the need for health needs assessment for developing services for the care and prevention of congenital disorders in middle- and low-income countries. However, these impediments stimulated the pioneering of innovate ways to offer medical genetic services in these circumstances, including tele-teaching of nurses and doctors, using cellular phones to enhance clinical care and adapting and assessing the clinical utility of a laboratory test, QF-PCR, for use in the local circumstances.

  14. Identification of Enhancers In Human: Advances In Computational Studies

    KAUST Repository

    Kleftogiannis, Dimitrios A.

    2016-03-24

    framework for identifying enhancers. The proposed system called Dragon Ensemble Enhancer Predictor (DEEP) is based on the novel deep learning two-layer ensemble algorithm capable of identifying enhancers characterized by different cellular conditions. Experimental results using data from ENCODE and FANTOM5, demonstrate that DEEP surpasses in terms of recognition performance the major systems for enhancer prediction and shows very good generalization capabilities in unknown cell-lines and tissues. Finally, we take a step further by developing a novel feature selection method suitable for defining a computational framework capable of analyzing the genomic content of enhancers and reporting cell-line specific predictive signatures.

  15. PROGRAMS WITH DATA MINING CAPABILITIES

    Directory of Open Access Journals (Sweden)

    Ciobanu Dumitru

    2012-03-01

    Full Text Available The fact that the Internet has become a commodity in the world has created a framework for anew economy. Traditional businesses migrate to this new environment that offers many features and options atrelatively low prices. However competitiveness is fierce and successful Internet business is tied to rigorous use of allavailable information. The information is often hidden in data and for their retrieval is necessary to use softwarecapable of applying data mining algorithms and techniques. In this paper we want to review some of the programswith data mining capabilities currently available in this area.We also propose some classifications of this softwareto assist those who wish to use such software.

  16. Indigenous Technological Innovation : Capability and ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... as determined by a Steering Committee of experts drawn from government agencies, universities and research institutions all over the country. It is expected to generate a body of evidence that will aid Chinese policymakers to develop and implement effective policies for enhancing indigenous innovations in the west.

  17. PERFECTED enhanced recovery (PERFECT-ER) care versus standard acute care for patients admitted to acute settings with hip fracture identified as experiencing confusion: study protocol for a feasibility cluster randomized controlled trial.

    Science.gov (United States)

    Hammond, Simon P; Cross, Jane L; Shepstone, Lee; Backhouse, Tamara; Henderson, Catherine; Poland, Fiona; Sims, Erika; MacLullich, Alasdair; Penhale, Bridget; Howard, Robert; Lambert, Nigel; Varley, Anna; Smith, Toby O; Sahota, Opinder; Donell, Simon; Patel, Martyn; Ballard, Clive; Young, John; Knapp, Martin; Jackson, Stephen; Waring, Justin; Leavey, Nick; Howard, Gregory; Fox, Chris

    2017-12-04

    Health and social care provision for an ageing population is a global priority. Provision for those with dementia and hip fracture has specific and growing importance. Older people who break their hip are recognised as exceptionally vulnerable to experiencing confusion (including but not exclusively, dementia and/or delirium and/or cognitive impairment(s)) before, during or after acute admissions. Older people experiencing hip fracture and confusion risk serious complications, linked to delayed recovery and higher mortality post-operatively. Specific care pathways acknowledging the differences in patient presentation and care needs are proposed to improve clinical and process outcomes. This protocol describes a multi-centre, feasibility, cluster-randomised, controlled trial (CRCT) to be undertaken across ten National Health Service hospital trusts in the UK. The trial will explore the feasibility of undertaking a CRCT comparing the multicomponent PERFECTED enhanced recovery intervention (PERFECT-ER), which acknowledges the differences in care needs of confused older patients experiencing hip fracture, with standard care. The trial will also have an integrated process evaluation to explore how PERFECT-ER is implemented and interacts with the local context. The study will recruit 400 hip fracture patients identified as experiencing confusion and will also recruit "suitable informants" (individuals in regular contact with participants who will complete proxy measures). We will also recruit NHS professionals for the process evaluation. This mixed methods design will produce data to inform a definitive evaluation of the intervention via a large-scale pragmatic randomised controlled trial (RCT). The trial will provide a preliminary estimate of potential efficacy of PERFECT-ER versus standard care; assess service delivery variation, inform primary and secondary outcome selection, generate estimates of recruitment and retention rates, data collection difficulties, and

  18. Technological capability at the Brazilian official pharmaceutical laboratories

    Directory of Open Access Journals (Sweden)

    José Vitor Bomtempo Martins

    2008-10-01

    Full Text Available This paper studies the technological capability in the Brazilian Official Pharmaceutical Laboratories [OPL]. The technological capability analysis could contribute to organization strategies and governmental actions in order to improve OPL basic tasks as well to incorporate new ones, particularly concerning the innovation management. Inspired in Figueiredo (2000, 2003a, 2003b and Figueiredo and Ariffin (2003, a framework was drawn and adapted to pharmaceutical industry characteristics and current sanitary and health legislation. The framework allows to map different dimensions of the technological capability (installations, processes, products, equipments, organizational capability and knowledge management and the level attained by OPL (ordinary or innovating capability. OPL show a good development of ordinary capabilities, particularly in Product and Processes. Concerning the other dimensions, OPL are quite diverse. In general, innovating capabilities are not much developed. In the short term, it was identified a dispersion in the capacitating efforts. Considering their present level and the absorption efforts, good perspectives can be found in Installations, Processes and Organizational Capability. A lower level of efforts in Products and Knowledge Management could undermine these capabilities in the future.

  19. Detection capabilities. Some historical footnotes

    International Nuclear Information System (INIS)

    Currie, L.A.

    2017-01-01

    Part I Summary of relevant topics from 1923 to present-including: Currie (Anal Chem 40:586-593, 1968) detection concepts and capabilities; International detection and uncertainty standards; Failure of classical "1"4C dating and birth of new scientific disciplines; Exploratory nuclear data analysis of "8"5Kr monitors found coincident with the collapse of the Iron Curtain (1989); Faulty statistics proved responsible for mistaken assertions that Currie's LC yields excessive false positives; Low-level counting and AMS for atmospheric "3"7Ar and µmolar fossil/biomass carbon in the environment; Erroneous assumption that our low-level background is a Poisson Process, linked to ∼8 % spurious anticoincidence events. Part II. Exact treatment of bivariate Poisson data-solved in 1930s by Przyborowski and Wilenski, Krakow University, for detecting extreme trace amounts of a malicious contaminant (dodder) in high purity seed standards. We adapted their treatment to detection capabilities in ultra-low-level nuclear counting. The timing of their work had great historical significance, marking the start of World War II, with the invasion of Poland (1939). (author)

  20. WFPC2 Science Capability Report

    Science.gov (United States)

    Brown, David I.

    2001-01-01

    In the following pages, a brief outline of the salient science features of Wide Field/Planetary Camera 2 (WFPC2) that impact the proposal writing process and conceptual planning of observations is presented. At the time of writing, WFPC2, while having been better defined than in the past, is far from being at the stage where science and engineering details are well enough known that concrete observational/operational sequences can be plannned with assurance. Conceptual issues are another matter. The thrust of the Science Capability Report at this time is to outline the known performance parameters and capabilities of WFPC2, filling in with specifications when necessary to hold a place for these items as they become known. Also, primary scientific and operational differences between WFPC 1 and 2 are discussed section-by-section, along with issues that remain to be determined and idiosyncrasies when known. Clearly the determination of the latter awaits some form of testing, most likely thermal/vacuum testing. All data in this report should be viewed with a jaundiced eye at this time.

  1. Enhancing regional collaboration -- taking the next step

    OpenAIRE

    Temple, Jennie M.

    2007-01-01

    CHDS State/Local Enhancing regional collaboration has been identified as one of the eight National Priorities for Homeland Security by the president of the United States. While South Carolina has made significant efforts in expanding regional collaboration, such as the creation of regional Counter Terrorism Coordinating Councils (CTCCs), there is still much work to be done. There are several teams and capabilities in place throughout the state, but they are uncoordinated, lack structure,...

  2. The Interface of IT Capabilities and Disruptive Innovations

    DEFF Research Database (Denmark)

    Baiyere, Abayomi

    2017-01-01

    The occurrence of disruptive innovations tends to challenge the fabric, structure and capability that define firms facing their threat. Prior research indicates that the capacity of a firm to restructure and reconfigure its resources to face/leverage such turbulent situations is dependent on how...... well it can orchestrate its capabilities. Although IT capability has been identified as one of the essential capability of today’s organisations, managers as well as researchers are yet to uncover the dynamics through which an organisation’s IT capability can be leveraged in disruptive innovation...... situations. This paper contributes to our understanding in this direction by conceptually exploring the different roles of an organisation's IT capabilitiy in disruptive innovation scenarios. The paper provides a synthesis of the current state of knowledge about both concepts and extends this to highlight...

  3. Resource-Based Capability on Development Knowledge Management Capabilities of Coastal Community

    Science.gov (United States)

    Teniwut, Roberto M. K.; Hasyim, Cawalinya L.; Teniwut, Wellem A.

    2017-10-01

    Building sustainable knowledge management capabilities in the coastal area might face a whole new challenge since there are many intangible factors involved from openness on new knowledge, access and ability to use the latest technology to the various local wisdom that still in place. The aimed of this study was to identify and analyze the resource-based condition of coastal community in this area to have an empirical condition of tangible and intangible infrastructure on developing knowledge management capability coastal community in Southeast Maluku, Indonesia. We used qualitative and quantitative analysis by depth interview and questionnaire for collecting the data with multiple linear regression as our analysis method. The result provided the information on current state of resource-based capability of a coastal community in this Southeast Maluku to build a sustainability model of knowledge management capabilities especially on utilization marine and fisheries resources. The implication of this study can provide an empirical information for government, NGO and research institution to dictate on how they conducted their policy and program on developing coastal community region.

  4. MHTGR inherent heat transfer capability

    International Nuclear Information System (INIS)

    Berkoe, J.M.

    1992-01-01

    This paper reports on the Commercial Modular High Temperature Gas-Cooled Reactor (MHTGR) which achieves improved reactor safety performance and reliability by utilizing a completely passive natural convection cooling system called the RCCS to remove decay heat in the event that all active cooling systems fail to operate. For the highly improbable condition that the RCCS were to become non-functional following a reactor depressurization event, the plant would be forced to rely upon its inherent thermo-physical characteristics to reject decay heat to the surrounding earth and ambient environment. A computational heat transfer model was created to simulate such a scenario. Plant component temperature histories were computed over a period of 20 days into the event. The results clearly demonstrate the capability of the MHTGR to maintain core integrity and provide substantial lead time for taking corrective measures

  5. Author's capabilities in author indexing

    International Nuclear Information System (INIS)

    Ooi, Shoichi

    1988-01-01

    The purpose of this paper is to provide a author capability of current author indexing practices in journal literature indexing practices in 'Journal of Nuclear Science and Technology of Japan'. This Journal employed keywords freely assigned by author and not taken from INIS Thesaurus or other vocabulary list. Author examined 413 literatures, comparing keywords assigned by the literatures' authors with descriptor's (ATOMINDEX) assigned by an experienced professional indexer. The results of the comparisons showed that the average set of terms assigned by author included about 70% of all the terms assigned to the same literature by the professional indexer. Authors eventually would contribute, for the most effective point to create reference to information is at the time of its generation. Consequently, it may be possible to transfer them easily to descriptors in every secondary information system. (author)

  6. Amartya Sen's Capability Approach and Education

    Science.gov (United States)

    Walker, Melanie

    2005-01-01

    The human capabilities approach developed by the economist Amartya Sen links development, quality of life and freedom. This article explores the key ideas in the capability approach of: capability, functioning, agency, human diversity and public participation in generating valued capabilities. It then considers how these ideas relate specifically…

  7. Organizational Economics of Capability and Heterogeneity

    DEFF Research Database (Denmark)

    Argyres, Nicholas S.; Felin, Teppo; Foss, Nicolai Juul

    2012-01-01

    For decades, the literatures on firm capabilities and organizational economics have been at odds with each other, specifically relative to explaining organizational boundaries and heterogeneity. We briefly trace the history of the relationship between the capabilities literature and organizational...... economics, and we point to the dominance of a “capabilities first” logic in this relationship. We argue that capabilities considerations are inherently intertwined with questions about organizational boundaries and internal organization, and we use this point to respond to the prevalent capabilities first...... logic. We offer an integrative research agenda that focuses first on the governance of capabilities and then on the capability of governance....

  8. Constructing a justice model based on Sen's capability approach

    OpenAIRE

    Yüksel, Sevgi; Yuksel, Sevgi

    2008-01-01

    The thesis provides a possible justice model based on Sen's capability approach. For this goal, we first analyze the general structure of a theory of justice, identifying the main variables and issues. Furthermore, based on Sen (2006) and Kolm (1998), we look at 'transcendental' and 'comparative' approaches to justice and concentrate on the sufficiency condition for the comparative approach. Then, taking Rawls' theory of justice as a starting point, we present how Sen's capability approach em...

  9. The Organizational Approach of Capability Theory: A Review Essay

    OpenAIRE

    Garzarelli, Giampaolo

    2006-01-01

    Richard Langlois, Tony Yu & Paul Robertson have assembled a collection of previously published papers that move beyond textbook production theory. This essay discusses work by Frank Knight and Hendrik Houthakker not reproduced in LYR in relation to the capability theory of economic organization. Knight identified the problem of organization as the search for and the coordination of different dispersed capabilities. Houthakker helps us to see more clearly that the benefits of specialization ar...

  10. The Absence of the Transcription Factor Yrr1p, Identified from Comparative Genome Profiling, Increased Vanillin Tolerance Due to Enhancements of ABC Transporters Expressing, rRNA Processing and Ribosome Biogenesis in Saccharomyces cerevisiae.

    Science.gov (United States)

    Wang, Xinning; Liang, Zhenzhen; Hou, Jin; Shen, Yu; Bao, Xiaoming

    2017-01-01

    Enhancing the tolerance of Saccharomyces cerevisiae to inhibitors derived from lignocellulose is conducive to producing biofuel and chemicals using abundant lignocellulosic materials. Vanillin is a major type of phenolic inhibitor in lignocellulose hydrolysates for S. cerevisiae . In the present work, the factors beneficial to vanillin resistance in yeast were identified from the vanillin-resistant strain EMV-8, which was derived from strain NAN-27 by adaptive evolution. We found 450 SNPs and 44 genes with InDels in the vanillin-tolerant strain EMV-8 by comparing the genome sequences of EMV-8 and NAN-27. To investigate the effects of InDels, InDels were deleted in BY4741, respectively. We demonstrated that the deletion of YRR1 improved vanillin tolerance of strain. In the presence of 6 mM vanillin, deleting YRR1 increase the maximum specific growth rate and the vanillin consumption rate by 142 and 51%, respectively. The subsequent transcriptome analysis revealed that deleting YRR1 resulted in changed expression of over 200 genes in the presence of 5 mM vanillin. The most marked changes were the significant up-regulation of the dehydrogenase ADH7 , several ATP-binding cassette (ABC) transporters, and dozens of genes involved in ribosome biogenesis and rRNA processing. Coincidently, the crude enzyme solution of BY4741( yrr1 Δ) exhibited higher NADPH-dependent vanillin reduction activity than control. In addition, overexpressing the ABC transporter genes PDR5, YOR1 , and SNQ2 , as well as the RNA helicase gene DBP2 , increased the vanillin tolerance of strain. Interestingly, unlike the marked changes we mentioned above, under vanillin-free conditions, there are only limited transcriptional differences between wildtype and yrr1 Δ. This indicated that vanillin might act as an effector in Yrr1p-related regulatory processes. The new findings of the relationship between YRR1 and vanillin tolerance, as well as the contribution of rRNA processing and ribosome biogenesis to

  11. Improving the Agency's Software Acquisition Capability

    Science.gov (United States)

    Hankinson, Allen

    2003-01-01

    External development of software has oftc n led to unsatisfactory results and great frustration for the assurE 7ce community. Contracts frequently omit critical assuranc 4 processes or the right to oversee software development activitie: At a time when NASA depends more and more on software to in plement critical system functions, combination of three factors ex; cerbate this problem: I ) the ever-increasing trend to acquire rather than develop software in-house, 2) the trend toward performance based contracts, and 3) acquisition vehicles that only state softwar 2 requirements while leaving development standards and assur! ince methodologies up to the contractor. We propose to identify specific methods at d tools that NASA projects can use to mitigate the adverse el ects of the three problems. TWO broad classes of methoddt ols will be explored. The first will be those that provide NASA p ojects with insight and oversight into contractors' activities. The st cond will be those that help projects objectively assess, and thus i nprwe, their software acquisition capability. Of particular interest is the Software Engineering Institute's (SEI) Software Acqt isition Capability Maturity Model (SA-CMMO).

  12. Systems Engineering for Space Exploration Medical Capabilities

    Science.gov (United States)

    Mindock, Jennifer; Reilly, Jeffrey; Rubin, David; Urbina, Michelle; Hailey, Melinda; Hanson, Andrea; Burba, Tyler; McGuire, Kerry; Cerro, Jeffrey; Middour, Chris; hide

    2017-01-01

    Human exploration missions that reach destinations beyond low Earth orbit, such as Mars, will present significant new challenges to crew health management. For the medical system, lack of consumable resupply, evacuation opportunities, and real-time ground support are key drivers toward greater autonomy. Recognition of the limited mission and vehicle resources available to carry out exploration missions motivates the Exploration Medical Capability (ExMC) Element's approach to enabling the necessary autonomy. The Element's work must integrate with the overall exploration mission and vehicle design efforts to successfully provide exploration medical capabilities. ExMC is applying systems engineering principles and practices to accomplish its goals. This paper discusses the structured and integrative approach that is guiding the medical system technical development. Assumptions for the required levels of care on exploration missions, medical system goals, and a Concept of Operations are early products that capture and clarify stakeholder expectations. Model-Based Systems Engineering techniques are then applied to define medical system behavior and architecture. Interfaces to other flight and ground systems, and within the medical system are identified and defined. Initial requirements and traceability are established, which sets the stage for identification of future technology development needs. An early approach for verification and validation, taking advantage of terrestrial and near-Earth exploration system analogs, is also defined to further guide system planning and development.

  13. OPSAID improvements and capabilities report.

    Energy Technology Data Exchange (ETDEWEB)

    Halbgewachs, Ronald D.; Chavez, Adrian R.

    2011-08-01

    Process Control System (PCS) and Industrial Control System (ICS) security is critical to our national security. But there are a number of technological, economic, and educational impediments to PCS owners implementing effective security on their systems. Sandia National Laboratories has performed the research and development of the OPSAID (Open PCS Security Architecture for Interoperable Design), a project sponsored by the US Department of Energy Office of Electricity Delivery and Energy Reliability (DOE/OE), to address this issue. OPSAID is an open-source architecture for PCS/ICS security that provides a design basis for vendors to build add-on security devices for legacy systems, while providing a path forward for the development of inherently-secure PCS elements in the future. Using standardized hardware, a proof-of-concept prototype system was also developed. This report describes the improvements and capabilities that have been added to OPSAID since an initial report was released. Testing and validation of this architecture has been conducted in another project, Lemnos Interoperable Security Project, sponsored by DOE/OE and managed by the National Energy Technology Laboratory (NETL).

  14. Atmospheric Release Advisory Capability (ARAC)

    International Nuclear Information System (INIS)

    Dickerson, M.H.

    1975-01-01

    The chief purpose of ARAC data acquisition program is to provide site officials, who are responsible for ensuring maximum health protection for the endangered site personnel and public, with estimates of the effects of atmospheric releases of hazardous material as rapidly and accurately as possible. ARAC is in the initial stages of being implemented and is therefore susceptible to changes before it reaches its final form. However the concept of ARAC is fully developed and was successfully demonstrated during a feasibility study conducted in June 1974, as a joint effort between the Savannah River Laboratory (SRL) and Lawrence Livermore Laboratory (LLL). Additional tests between SRL and LLL are scheduled for December 1975. While the immediate goal is the application of ARAC to assist a limited number of ERDA sites, the system is designed with sufficient flexibility to permit expanding the service to a large number of sites. Success in ARAC application should provide nuclear facilities with a means to handle better the urgent questions concerning the potential accidental hazards from atmospheric releases in addition to providing the sites with a capability to assess the effort of their normal operations

  15. Sensing capabilities of graphite based MR elastomers

    International Nuclear Information System (INIS)

    Tian, T F; Li, W H; Deng, Y M

    2011-01-01

    This paper presents both experimental and theoretical investigations of the sensing capabilities of graphite based magnetorheological elastomers (MREs). In this study, eight MRE samples with varying graphite weight fractions were fabricated and their resistance under different magnetic fields and external loadings were measured with a multi-meter. With an increment of graphite weight fraction, the resistance of MRE sample decreases steadily. Higher magnetic fields result in a resistance increase. Based on an ideal assumption of a perfect chain structure, a mathematical model was developed to investigate the relationship between the MRE resistance with external loading. In this model, the current flowing through the chain structure consists of both a tunnel current and a conductivity current, both of which depend on external loadings. The modelling parameters have been identified and reconstructed from comparison with experimental results. The comparison indicates that both experimental results and modelling predictions agree favourably well

  16. MODERN CAPABILITIES OF BREAST PATHOLOGY DIAGNOSTICS

    Directory of Open Access Journals (Sweden)

    I. V. Vysotskaya

    2015-01-01

    Full Text Available Every year more than 1 million new cases of breast cancer are being recorded worldwide. Choice of appropriate tactics of treatment depends on the timely diagnosis and correct assessment of the prevalence of cancer.The algorithm of patient»s examination includes clinical examination, X-ray mammography and ultrasonic diagnosis of breast. However, this is not sufficient for a complete interpretation of the patient»s condition in case of non-palpable breast formations, ambiguous interpretation of imaging under structural changes, increased density of breast tissue, etc.In this regard, the introduction of new technologies and their evaluation in terms of practicality is a logical and developing method of early diagnosis of breast pathology.One of the methods that enables enhancing the information capability of ultrasonic diagnosis of breast is elastography. It allows for the differential diagnosis of benign and malignant changes not only in the breast tissue, but also in the areas of regional lymph drainage.Promising method of modern diagnostic breast care is digital mammography tomosynthesis. However, in spite of the first and very optimisticdata, this technique is still far from standard.Complex diagnostics of breast pathology, in addition to clinical data and imaging results, are based on information obtained from biopsies. At the present stage core-biopsy is considered as the best way of verification, where the resulting material is subjected to immunohistochemical studies.Thus, the spectrum of diagnostic capabilities is constantly expanding. Highly informative techniques included in the daily practice today enable clinicians to achieve optimal results in curing even greater number of patients.

  17. Contingency strategy for insufficient full core off load capability in spent fuel pool for Chinshan nuclear power station

    International Nuclear Information System (INIS)

    Huang, Pinghue

    2012-01-01

    The spent fuel pool (SFP) at Taiwan Power Company's (TUC's) Chinshan plant lost the full core off load (FCO) capability in 2010, even with the second SFP repacking project to expand the capacity as reported in 12PBNC. The TEPC had originally planned to move some spent fuel assemblies from SFP to dry storage facility, however, the dry storage project had seriously fell behind. Thus, it is required to address insufficient FCO capability, and the following contingency measures have been employed: The first step was to explore whether there was a specific regulatory requirement for FCO capability, and none were identified. Also, the industrial experiences were explored. The refueling strategy is changed from FCO to in-core shuffling. A feasibility evaluation performed indicates the Technical Specifications require: alternate method of decay heat removal, and verification of shutdown margin for each in vessel fuel movement. Specific methods have been successfully established. A safety evaluation for operation without FCO capability was performed, and no safety concerns were identified. The risk for operation without FCO capability was assessed. The previous operational experiences were identified. Moreover, such works are not expected in subsequent cycles. The new fuel vault is used to store new fuel assemblies. The criticality analysis has been performed and some new approaches are proposed to enhance the storage flexibility as reported in 17PBNC. An inter-unit transfer cask has been designed to transfer spent fuel from the SFP of one unit to the other. The FCO capability can be effectively extended for three more years with this consideration. The TPC discussed the contingency strategy with the ROCAEC in May 2006, and the ROCAEC's concurrence was attained. With the proposed strategy, Chinshan units have been operating smoothly

  18. Contingency strategy for insufficient full core off load capability in spent fuel pool for Chinshan nuclear power station

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Pinghue [Taiwan Power Company, Taipei (China)

    2012-03-15

    The spent fuel pool (SFP) at Taiwan Power Company's (TUC's) Chinshan plant lost the full core off load (FCO) capability in 2010, even with the second SFP repacking project to expand the capacity as reported in 12PBNC. The TEPC had originally planned to move some spent fuel assemblies from SFP to dry storage facility, however, the dry storage project had seriously fell behind. Thus, it is required to address insufficient FCO capability, and the following contingency measures have been employed: The first step was to explore whether there was a specific regulatory requirement for FCO capability, and none were identified. Also, the industrial experiences were explored. The refueling strategy is changed from FCO to in-core shuffling. A feasibility evaluation performed indicates the Technical Specifications require: alternate method of decay heat removal, and verification of shutdown margin for each in vessel fuel movement. Specific methods have been successfully established. A safety evaluation for operation without FCO capability was performed, and no safety concerns were identified. The risk for operation without FCO capability was assessed. The previous operational experiences were identified. Moreover, such works are not expected in subsequent cycles. The new fuel vault is used to store new fuel assemblies. The criticality analysis has been performed and some new approaches are proposed to enhance the storage flexibility as reported in 17PBNC. An inter-unit transfer cask has been designed to transfer spent fuel from the SFP of one unit to the other. The FCO capability can be effectively extended for three more years with this consideration. The TPC discussed the contingency strategy with the ROCAEC in May 2006, and the ROCAEC's concurrence was attained. With the proposed strategy, Chinshan units have been operating smoothly.

  19. Identifying knowledge in decision-making processes

    DEFF Research Database (Denmark)

    Jensen, Anna Rose Vagn; Ahmed-Kristensen, Saeema

    2010-01-01

    Managing knowledge reflects the innovation capability of a company. Mapping decision processes and links to knowledge is a way to learn more in structuring knowledge in innovation processes. Through an empirical study the paper aims to identify knowledge...

  20. Identifying significant environmental features using feature recognition.

    Science.gov (United States)

    2015-10-01

    The Department of Environmental Analysis at the Kentucky Transportation Cabinet has expressed an interest in feature-recognition capability because it may help analysts identify environmentally sensitive features in the landscape, : including those r...

  1. Alliance capability as a mediator between experience and alliance performance

    DEFF Research Database (Denmark)

    Heimeriks, Koen; Duysters, Geert

    This study centers around the way in which firms can enhance alliance performance through the development of alliance capabilities. Whereas most research has focused on inter-firm antecedents of alliance performance, research on intra-firm antecedents pointing to prior experience and internal...... alliance managers and Vice-Presidents of 151 firms. The survey covers over 2600 alliances for the period 1997-2001. This study not only finds that alliance capabilities partially mediate between alliance experience and alliance performance, but also yields novel insights into the micro-level building...

  2. Researching pharmacist managerial capability: philosophical perspectives and paradigms of inquiry.

    Science.gov (United States)

    Woods, Phillip; Gapp, Rod; King, Michelle A

    2015-01-01

    In successful community pharmacy business enterprises suitably responsive actions to meet ever-increasing change require capable pharmacy managers who readily learn and adapt. Capability as a concept is generally understood to be the ability of a manager to identify and act to solve unfamiliar problems in unfamiliar situations. Capability is characterized by adaptability and flexibility. However, different understandings of the concept 'capability' and what it means to be 'capable' are indirect and incomplete. This paper aims to clarify current theories regarding the concept of 'capability' at the level of the individual, and through this to make more explicit what is known about the phenomenon, but more particularly, how we know what we know. The analysis includes the concept of 'competence' because explanations of capability include competence, and the two concepts are not clearly separated in the literature. By probing the epistemological origins of current theory concerning both concepts, the limiting taken for granted assumptions are revealed. Assumptions about context and time, and the psychological theory through which individuals are assumed to perceive, know and learn, are illuminated. The analysis, in connection with the literature, shows how the interpretive philosophic research approach may reveal a different and useful theoretical perspective for explaining capability as a dynamic performance. It is suggested that such a perspective may narrow the gap between the theory of capability and its practice. The interpretive perspective holds potential to reveal how capability, as performed by successful community pharmacy managers, might be further researched and strengthened. This paper supports the challenging suggestion that pharmacy social research needs to rebalance the dominance of purely empirical research by exploring interpretive methodologies to better understand human actions and relations in the context of pharmacy. Crown Copyright © 2015

  3. Global dynamics, capabilities and the crisis

    Czech Academy of Sciences Publication Activity Database

    Fagerberg, J.; Srholec, Martin

    2016-01-01

    Roč. 26, č. 4 (2016), s. 765-784 ISSN 0936-9937 Institutional support: PRVOUK-P23 Keywords : technological capabilities * social capabilities * competitiveness Subject RIV: AH - Economics Impact factor: 0.862, year: 2016

  4. Liberalism, Humanism, and Feminism in Nussbaum's Capabilities ...

    African Journals Online (AJOL)

    A purely theoretical analysis of Martha Nussbaum's basis of the capabilities ... Since even a capabilities approach rooted in feminist justice is itself radical and must ... rhetoric of sex and social justice that has already been embraced by current

  5. Sandia Laboratories technical capabilities: systems analysis

    International Nuclear Information System (INIS)

    Lundergan, C.D.

    1975-06-01

    The systems analysis capabilities at Sandia Laboratories are summarized. Selected applications of these capabilities are presented to illustrate the extent to which they can be applied in research and development programs. (U.S.)

  6. Sandia Laboratories technical capabilities: engineering analysis

    International Nuclear Information System (INIS)

    Lundergan, C.D.

    1975-12-01

    This report characterizes the engineering analysis capabilities at Sandia Laboratories. Selected applications of these capabilities are presented to illustrate the extent to which they can be applied in research and development programs

  7. DDP-516 Computer Graphics System Capabilities

    Science.gov (United States)

    1972-06-01

    This report describes the capabilities of the DDP-516 Computer Graphics System. One objective of this report is to acquaint DOT management and project planners with the system's current capabilities, applications hardware and software. The Appendix i...

  8. Managing key capabilities: A challenge for nuclear plant building companies

    International Nuclear Information System (INIS)

    Pascal Corbel

    2003-01-01

    The nuclear plant building industry faces a paradoxical situation. The use of nuclear reactors to produce energy for civil purposes is both a promising technology, with potentially huge outlets, and a technology facing declining demand. One of the key problems is then: how to maintain the capabilities necessary to benefit from the potential recovery? The resource-based view of strategic management has shown the importance of different types of resources and capabilities in gaining a sustainable competitive advantage. Successful incumbents in the market of nuclear station building have built those kinds of distinctive capabilities that give them a competitive advantage over potential new entrants. But we show that, without a permanent activity in plant building, preserving those capabilities necessitates specific strategic action. We firstly develop the argument that the nuclear plant building industry is in a paradoxical situation in terms of demand and technical performance trends. Secondly, we try to identify the key capabilities of the incumbents. We show that companies in that field use mainly three types of distinctive capabilities: pure technical and scientific knowledge in direct relation to the use of nuclear as an energy generator, competences in risk management and competences in large project management, including financing. Thirdly, we show that although some of those capabilities are used through other nuclear-related activities such as plant maintenance or fuel supply, some of them necessitate taking strategic actions in order to be preserved. We argue that this should be a priority of nuclear equipment company managers in the next few years. (author)

  9. Array capabilities and future arrays

    International Nuclear Information System (INIS)

    Radford, D.

    1993-01-01

    Early results from the new third-generation instruments GAMMASPHERE and EUROGAM are confirming the expectation that such arrays will have a revolutionary effect on the field of high-spin nuclear structure. When completed, GAMMASHPERE will have a resolving power am order of magnitude greater that of the best second-generation arrays. When combined with other instruments such as particle-detector arrays and fragment mass analysers, the capabilites of the arrays for the study of more exotic nuclei will be further enhanced. In order to better understand the limitations of these instruments, and to design improved future detector systems, it is important to have some intelligible and reliable calculation for the relative resolving power of different instrument designs. The derivation of such a figure of merit will be briefly presented, and the relative sensitivities of arrays currently proposed or under construction presented. The design of TRIGAM, a new third-generation array proposed for Chalk River, will also be discussed. It is instructive to consider how far arrays of Compton-suppressed Ge detectors could be taken. For example, it will be shown that an idealised open-quote perfectclose quotes third-generation array of 1000 detectors has a sensitivity an order of magnitude higher again than that of GAMMASPHERE. Less conventional options for new arrays will also be explored

  10. Towards a dynamic concept of alliance capability

    OpenAIRE

    SLUYTS, Kim; MARTENS, Rudy; MATTHYSSENS, Paul

    2008-01-01

    This paper has a threefold purpose. First, we offer a literature review on alliance capability based on strategic and competence based management literature. Second, we extend existing literature on alliance capability by breaking this concept down into five sub capabilities, which are each linked to a stage of the alliance life cycle. Finally, we suggest how firms can support these capabilities through structural, technological and people-related tools and techniques. We argue that current l...

  11. Capabilities of nitrogen admixed cryogenic deuterium pellets

    Energy Technology Data Exchange (ETDEWEB)

    Sharov, Igor; Sergeev, Vladimir [SPU, Saint-Petersburg (Russian Federation); Lang, Peter; Ploeckl, Bernhard; Cavedon, Marco [Max-Planck-Institut fuer Plasmaphysik, Garching (Germany); Kocsis, Gabor; Szepesi, Tamas [Wigner RCP RMI, Budapest (Hungary); Collaboration: ASDEX Upgrade Team

    2015-05-01

    Operation at high core density with high energy confinement - as foreseen in a future fusion reactor like DEMO - is being investigated at ASDEX Upgrade tokamak. The efficiency of pellet fuelling from the high-field side usually increases with increasing injection speed. Due to the fragile nature of the deuterium ice, however, the increment of pellet mass losses and subsequent pellet fragmentations take place when the speed is increased. Studies show, that admixing of a small amount of nitrogen (N{sub 2}) into D{sub 2} gas can be favorable for the mechanical stability of pellets. This might be helpful for deeper pellet penetration. Besides, seeding by N{sub 2} can enhance plasma performance due to both increasing the energy confinement time and reducing the divertor heat load in the envisaged ELMy H-mode plasma scenario. Fuelling efficiency of N{sub 2}-admixed solid D{sub 2} pellets and their nitrogen seeding capabilities were investigated. It was found that both the overall plasma density increase and the measured averaged pellet penetration depth were smaller in case of the admixed (1% mol. in the gas resulting in about 0.8% in the ice) pellet fuelling. Possibility of the N{sub 2}-seeding by admixed pellets was confirmed by CXRS measurements of N{sup 7+} content in plasma.

  12. Combining Land Capability Evaluation, Geographic Information ...

    African Journals Online (AJOL)

    Combining Land Capability Evaluation, Geographic Information Systems, AnD Indigenous Technologies for Soil Conservation in Northern Ethiopia. ... Land capability and land use status were established following the procedures of a modified treatment-oriented capability classification using GIS. The case study ...

  13. Organisational Capability--What Does It Mean?

    Science.gov (United States)

    National Centre for Vocational Education Research (NCVER), 2006

    2006-01-01

    Organisational capability is rapidly becoming recognized as the key to organizational success. However, the lack of research on it has been well documented in the literature, and organizational capability remains an elusive concept. Yet an understanding of organizational capability can offer insights into how RTOs might work most effectively,…

  14. Selecting Capabilities for Quality of Life Measurement

    Science.gov (United States)

    Robeyns, Ingrid

    2005-01-01

    The capability approach advocates that interpersonal comparisons be made in the space of functionings and capabilities. However, Amartya Sen has not specified which capabilities should be selected as the relevant ones. This has provoked two types of criticism. The stronger critique is Martha Nussbaum's claim that Sen should endorse one specific…

  15. Capturing Firms’ Heterogeneity through Marketing and IT Capabilities in SMEs

    Directory of Open Access Journals (Sweden)

    María A. Ramón-Jerónimo

    2017-11-01

    Full Text Available To achieve sustainability, firms capable of surviving economic recessions is of key relevance; the capabilities that firms need to face dynamic environments remain an open question. In this work, a new procedure is proposed to capture firms’ heterogeneity with regard to the capabilities they possess in operating efficiently in dynamic environments. This approach enables the identification of the classes of firms that develop efficiency with a specific integration of resources. While the literature has most often measured firm capabilities using subjective measures, this study suggests the use of Data Envelopment Analysis to capture the ability to transform resources into outcomes and of Latent Class Regression to capture differences across firms that explain firms’ heterogeneity in the way they perform. By combining these two techniques, this work presents a way to identify those firms that need to invest in and develop certain capabilities. This work analyses a large dataset of manufacturing Small Medium Enterprises (SMEs extracted from the Business and Strategy survey provided by Fundación de la Sociedad Estatal de Participaciones Industriales( SEPI in Spain. The dataset used enfolds 10,960 observations from 2048 firms during the period 1994–2011. The complete dataset has been employed to calculate manufacturing firms’ efficiency. In a second step, data were cleaned to eliminate outliers, and to identify SMEs and observations with records of IT capabilities. As a result, 329 manufacturing SMEs were analysed to capture their heterogeneity. The results contribute to the current literature by explaining how manufacturing SMEs show a different need in their development of capabilities to be efficient and adapt to environmental changes. While approximately 20% of firms analysed really take advantage of recessions through their investment in R&D, the remaining 80% need to adjust their size or invest in IT capabilities to become competitive

  16. The Advanced Modeling, Simulation and Analysis Capability Roadmap Vision for Engineering

    Science.gov (United States)

    Zang, Thomas; Lieber, Mike; Norton, Charles; Fucik, Karen

    2006-01-01

    This paper summarizes a subset of the Advanced Modeling Simulation and Analysis (AMSA) Capability Roadmap that was developed for NASA in 2005. The AMSA Capability Roadmap Team was chartered to "To identify what is needed to enhance NASA's capabilities to produce leading-edge exploration and science missions by improving engineering system development, operations, and science understanding through broad application of advanced modeling, simulation and analysis techniques." The AMSA roadmap stressed the need for integration, not just within the science, engineering and operations domains themselves, but also across these domains. Here we discuss the roadmap element pertaining to integration within the engineering domain, with a particular focus on implications for future observatory missions. The AMSA products supporting the system engineering function are mission information, bounds on information quality, and system validation guidance. The Engineering roadmap element contains 5 sub-elements: (1) Large-Scale Systems Models, (2) Anomalous Behavior Models, (3) advanced Uncertainty Models, (4) Virtual Testing Models, and (5) space-based Robotics Manufacture and Servicing Models.

  17. Environments for online maritime simulators with cloud computing capabilities

    Science.gov (United States)

    Raicu, Gabriel; Raicu, Alexandra

    2016-12-01

    This paper presents the cloud computing environments, network principles and methods for graphical development in realistic naval simulation, naval robotics and virtual interactions. The aim of this approach is to achieve a good simulation quality in large networked environments using open source solutions designed for educational purposes. Realistic rendering of maritime environments requires near real-time frameworks with enhanced computing capabilities during distance interactions. E-Navigation concepts coupled with the last achievements in virtual and augmented reality will enhance the overall experience leading to new developments and innovations. We have to deal with a multiprocessing situation using advanced technologies and distributed applications using remote ship scenario and automation of ship operations.

  18. Electron identification capabilities of CBM

    Energy Technology Data Exchange (ETDEWEB)

    Lebedev, Semen [GSI, Darmstadt (Germany)]|[JINR, Dubna (Russian Federation)

    2008-07-01

    The Compressed Baryonic Matter (CBM) experiment at the future FAIR facility at Darmstadt will measure dileptons emitted from the hot and dense phase in heavy-ion collisions. In case of an electron measurement, a high purity of identified electrons is required in order to suppress the background. Electron identification in CBM will be performed by a RICH and TRD detectors. In this contribution we will present routines which have been developed for electron identification in CBM. A RICH ring recognition algorithm based on the Hough Transform has been implemented. An ellipse fitting algorithm has been elaborated because most of the CBM RICH rings have elliptic shapes, moreover, it helps to improve ring-track matching and electron identification procedures. An Artificial Neural Network can be used in order to suppress fake rings. The electron identification in RICH is substantially improved by the use of TRD information for which 3 different algorithms are implemented. Results of primary electron identification are presented. All developed algorithms were tested on large statistics of simulated events and are included into the CBM software framework for common use.

  19. Exploring the resource and capabilities of food related enterprises in ...

    African Journals Online (AJOL)

    Specifically, the two case studies illustrate the capabilities of business owners to identify assets at their establishments and the municipality level and reconfigure them into objects aimed at providing experiences for visitors seeking out for rural idyll. The implications of this study on policy and practice on entrepreneurship ...

  20. Work program analysis - defining the capability/risk plan

    International Nuclear Information System (INIS)

    Hrinivich, W.A.

    2004-01-01

    Bruce Power has developed and implemented an analysis methodology (Work Program Analysis) to assess and address corporate business risk associated with work group capability. Work Program Analysis is proving to be an excellent tool for identifying and supporting key business decisions facing the line and senior management at Bruce Power. The following describes the methodology, its application and the results achieved. (author)

  1. Managing Capabilities for Supply Chain Resilience Through it Integration

    Directory of Open Access Journals (Sweden)

    Gružauskas Valentas

    2017-08-01

    Full Text Available The trend for e-commerce, estimated population size to 11 billion by 2050, and an increase in urbanization level to 70 % is requiring to re-think the current supply chain. These trends changed the distribution process: delivery distances are decreasing, the product variety is increasing, and more products are being sold in smaller quantities. Therefore, the concept of supply chain resilience has gained more recognition in recent years. The scientific literature analysis conducted by the authors indicate several capabilities that influence supply chain resilience. Collaboration, flexibility, redundancy and integration are the most influential capabilities to supply chain resilience. However, the authors identify that the combination of these capabilities to supply chain resilience is under researched. The authors indicate that by combining these capabilities with the upcoming technologies of industry 4.0, supply chain resilience can be achieved. In the future, the authors are planning to conduct further research to identify the influence of these capabilities to supply chain resilience, to quantify supply chain resilience, and to provide further practices of industry 4.0 concept usage for supply chain resilience.

  2. Integration of resilience capabilities for Critical Infrastructures into the Emergency Management set-up

    DEFF Research Database (Denmark)

    Kozine, Igor; Andersen, Henning Boje

    2015-01-01

    We suggest an approach for maintaining and enhancing resilience that integrates the resilience capabilities of Critical Infrastructures (CIs) into the emergency management cycle (prevention, preparedness, response, and recovery). This allows emergency services to explicitly address resilience...

  3. Delivering SSA Capabilities to the Warfighter

    Science.gov (United States)

    van Weezendonk, J.; Sherk, J.; Ryan, T.; McGuire, R.

    The Space Superiority Systems Wing at the Space and Missile Center (SMC/SY) equips US forces with Offensive Counterspace (OCS), Defensive Counterspace (DCS), and Space Situation Awareness (SSA) systems that further enhance space superiority. The Technology Division (SYT) mission is to identify, develop, and transition cutting-edge technologies to the warfighter. SYT invests in the most relevant technologies for SSA, DCS and OCS that enhance SMC/SY's portfolio. This presentation will provide an overview of the SMC/SY SSA Technology being worked and highlights several key programs. The presentation will also highlight how the SMC/SY SSA efforts fit into to a Space Superiority Architecture. SYT executes its own Space Control Technology program line and leverages technologies from various DoD and national laboratories, Federally Funded Research and Development Companies, national agencies, industry and academia to accomplish their mission. The portions of the SY FY06 SSA portfolio that will be discussed are: Precision Metrics, Star Sensor Studies, Multi-mission Deployable Optical System, Intelligent Agent Data Fusion efforts, ESSA ACTD and the GReAT tech demo.

  4. European contract law and the capabilities approach: on distributive responsibility for contract law

    NARCIS (Netherlands)

    Tjon Soei Len, L.; Weidtmann, N.; Hölzchen, Y.M.; Hawa, B.

    2012-01-01

    This paper argues that the normative requirements of Nussbaum’s capabilities approach extend to contract law (and private law more broadly). Contract law is part of a society’s basic structure, i.e. the responsibility bearing structure that is to secure and enhance individuals’ basic capabilities.

  5. Compilation of Sandia Laboratories technical capabilities

    International Nuclear Information System (INIS)

    Lundergan, C.D.; Mead, P.L.

    1975-11-01

    This report is a compilation of 17 individual documents that together summarize the technical capabilities of Sandia Laboratories. Each document in this compilation contains details about a specific area of capability. Examples of application of the capability to research and development problems are provided. An eighteenth document summarizes the content of the other seventeen. Each of these documents was issued with a separate report number (SAND 74-0073A through SAND 74-0091, except -0078)

  6. Compilation of Sandia Laboratories technical capabilities

    Energy Technology Data Exchange (ETDEWEB)

    Lundergan, C. D.; Mead, P. L. [eds.

    1975-11-01

    This report is a compilation of 17 individual documents that together summarize the technical capabilities of Sandia Laboratories. Each document in this compilation contains details about a specific area of capability. Examples of application of the capability to research and development problems are provided. An eighteenth document summarizes the content of the other seventeen. Each of these documents was issued with a separate report number (SAND 74-0073A through SAND 74-0091, except -0078). (RWR)

  7. Methods of ecological capability evaluation of forest

    International Nuclear Information System (INIS)

    Hosseini, M.; Makhdoum, M.F.; Akbarnia, M.; Saghebtalebi, Kh.

    2000-01-01

    In this research common methods of ecological capability evaluation of forests were reviewed and limitations for performance were analysed. Ecological capability of forests is an index that show site potential in several role of wood production, soil conservation, flood control, biodiversity, conservation and water supply. This index is related to ecological characteristics of land, such as soil, micro climate, elevation, slope and aspect that affect potential of sites. Suitable method of ecological capability evaluation must be chosen according to the objective of forestry. Common methods for ecological capability evaluation include plant and animal diversity, site index curve, soil and land form, inter branches, index plants, leave analyses, analyses regeneration and ecological mapping

  8. Development of a gamma ray spectroscopy capability at LANSCE

    International Nuclear Information System (INIS)

    Nelson, R.O.; Strottman, D.D.; Sterbenz, S.M.

    1998-01-01

    This is the final report of a one-year, Laboratory Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). The goal of this project was to explore an upgrade to the GEANIE high-resolution gamma-ray spectrometer at the Los Alamos Neutron Science Center (LANSCE) to help build additional experimental capabilities. The improvements identified have significantly added to the capabilities of GEANIE and made the facility more attractive for studies supporting the core national security mission as well as for use by outside collaborators. These benefits apply to both basic and applied studies

  9. Business Systems Branch Abilities, Capabilities, and Services Web Page

    Science.gov (United States)

    Cortes-Pena, Aida Yoguely

    2009-01-01

    During the INSPIRE summer internship I acted as the Business Systems Branch Capability Owner for the Kennedy Web-based Initiative for Communicating Capabilities System (KWICC), with the responsibility of creating a portal that describes the services provided by this Branch. This project will help others achieve a clear view ofthe services that the Business System Branch provides to NASA and the Kennedy Space Center. After collecting the data through the interviews with subject matter experts and the literature in Business World and other web sites I identified discrepancies, made the necessary corrections to the sites and placed the information from the report into the KWICC web page.

  10. Developing A/E capabilities; areas of special interest

    International Nuclear Information System (INIS)

    Gonzalez, A.; Gurbindo, J.

    1988-01-01

    During the last few years, the methods used by Empresarios Agrupados and INITEC to perform Architect-Engineering work in Spain for nuclear projects has undergone a process of significant change in project management and engineering approaches. Specific practical examples of management techniques and design practices which represent a good record of results will be discussed. They are identified as areas of special interest in developing A/E capabilities for nuclear projects. Command of these areas should produce major payoffs in local participation and contribute to achieving real nuclear engineering capabilities in the country

  11. An Approach for Identifying and Characterising Problems in the Iterative Development of C3l Capability.

    Science.gov (United States)

    1999-11-01

    OverviewNo. 23/1998, Australian Department of Defence. Denzin , N. K. and Y. S. Lincoln , Eds. (1994). Handbook of Qualitative Research. SAGE...Frey (1994). Interviewing: The Art of Science. In Handbook of Qualitative Research. (N. K. Denzin and Y. S. Lincoln . Eds.), pp. 377-392, SAGE...general. Yin’s book (1994) on case studies is worth reading, and Denzin (1994) provides a more detailed collection of papers on specific techniques, such

  12. 78 FR 26810 - Adequacy of Design Features and Functional Capabilities Identified and Described for Withstanding...

    Science.gov (United States)

    2013-05-08

    ... is available in ADAMS under Accession No. ML12276A112. NRC's PDR: You may examine and purchase copies... considerations have already been addressed. The NRC staff has no intention to impose the SRP positions on current... intention to impose the SRP positions on current licensees and regulatory approvals either now or in the...

  13. Identifying Capabilities Gaps in Shipboard Visit, Board, Search, Seizure (VBSS) Teams

    Science.gov (United States)

    2010-12-01

    always remains some risk, however small, of a data breach . Anticipated Benefits. Anticipated benefits from this study are potentially increasing the...there always remains some risk, however small, of a data breach . Anticipated Benefits. Anticipated benefits from this study are potentially

  14. Assessment of Space Nuclear Thermal Propulsion Facility and Capability Needs

    Energy Technology Data Exchange (ETDEWEB)

    James Werner

    2014-07-01

    The development of a Nuclear Thermal Propulsion (NTP) system rests heavily upon being able to fabricate and demonstrate the performance of a high temperature nuclear fuel as well as demonstrating an integrated system prior to launch. A number of studies have been performed in the past which identified the facilities needed and the capabilities available to meet the needs and requirements identified at that time. Since that time, many facilities and capabilities within the Department of Energy have been removed or decommissioned. This paper provides a brief overview of the anticipated facility needs and identifies some promising concepts to be considered which could support the development of a nuclear thermal propulsion system. Detailed trade studies will need to be performed to support the decision making process.

  15. Nuclear Hybrid Energy System Modeling: RELAP5 Dynamic Coupling Capabilities

    Energy Technology Data Exchange (ETDEWEB)

    Piyush Sabharwall; Nolan Anderson; Haihua Zhao; Shannon Bragg-Sitton; George Mesina

    2012-09-01

    The nuclear hybrid energy systems (NHES) research team is currently developing a dynamic simulation of an integrated hybrid energy system. A detailed simulation of proposed NHES architectures will allow initial computational demonstration of a tightly coupled NHES to identify key reactor subsystem requirements, identify candidate reactor technologies for a hybrid system, and identify key challenges to operation of the coupled system. This work will provide a baseline for later coupling of design-specific reactor models through industry collaboration. The modeling capability addressed in this report focuses on the reactor subsystem simulation.

  16. Developing maturity grids for assessing organisational capabilities

    DEFF Research Database (Denmark)

    Maier, Anja; Moultrie, James; Clarkson, P John

    2009-01-01

    Keyword: Maturity Model,Maturity Grid,Maturity Matrix,Organisational Capabilities,Benchmarking,New Product Development,Perfirmance Assessment......Keyword: Maturity Model,Maturity Grid,Maturity Matrix,Organisational Capabilities,Benchmarking,New Product Development,Perfirmance Assessment...

  17. Global dynamics, capabilities and the crisis

    Czech Academy of Sciences Publication Activity Database

    Fagerberg, J.; Srholec, Martin

    2016-01-01

    Roč. 26, č. 4 (2016), s. 765-784 ISSN 0936-9937 R&D Projects: GA ČR GAP402/10/2310 Institutional support: RVO:67985998 Keywords : technological capabilities * social capabilities * competitiveness Subject RIV: AH - Economics Impact factor: 0.862, year: 2016

  18. Making Capability Lists: Philosophy versus Democracy

    NARCIS (Netherlands)

    Claassen, R.J.G.

    2011-01-01

    The article discusses a fundamental problem that has to be faced if the general capability approach is to be developed in the direction of a theory of justice: the selection and justification of a list of capabilities. The democratic solution to this problem (defended by Amartya Sen) is to leave the

  19. Networking capability and new product development

    NARCIS (Netherlands)

    Mu, J.; Di Benedetto, A.C.

    2012-01-01

    Current research on network theory remains largely focused on structures and outcomes without exploring the capability that firms need to build efficient and effective networks to their advantage. In this paper, we take a networking capability view in studying inter-firm relationships. We assume

  20. Cultivating Human Capabilities in Venturesome Learning Environments

    Science.gov (United States)

    Hogan, Padraig

    2013-01-01

    The notion of competencies has been a familiar feature of educational reform policies for decades. In this essay, Padraig Hogan begins by highlighting the contrasting notion of capabilities, pioneered by the research of Amartya Sen and Martha Nussbaum. An educational variant of the notion of capabilities then becomes the basis for exploring…

  1. A framework for offshore vendor capability development

    Science.gov (United States)

    Yusuf Wibisono, Yogi; Govindaraju, Rajesri; Irianto, Dradjad; Sudirman, Iman

    2016-02-01

    Offshore outsourcing is a common practice conducted by companies, especially in developed countries, by relocating one or more their business processes to other companies abroad, especially in developing countries. This practice grows rapidly owing to the ease of accessing qualified vendors with a lower cost. Vendors in developing countries compete more intensely to acquire offshore projects. Indonesia is still below India, China, Malaysia as main global offshore destinations. Vendor capability is among other factors that contribute to the inability of Indonesian vendor in competing with other companies in the global market. Therefore, it is essential to study how to increase the vendor's capability in Indonesia, in the context of global offshore outsourcing. Previous studies on the vendor's capability mainly focus on capabilities without considering the dynamic of capabilities due to the environmental changes. In order to be able to compete with competitors and maintain the competitive advantage, it is necessary for vendors to develop their capabilities continuously. The purpose of this study is to develop a framework that describes offshore vendor capability development along the client-vendor relationship stages. The framework consists of three main components, i.e. the stages of client-vendor relationship, the success of each stage, and the capabilities of vendor at each stage.

  2. Towards a national cybersecurity capability development model

    CSIR Research Space (South Africa)

    Jacobs, Pierre C

    2017-06-01

    Full Text Available to be broken down into its components, a model serves as a blueprint to ensure that those building the capability considers all components, allows for cost estimation and facilitates the evaluation of trade-offs. One national cybersecurity capability...

  3. Adult Financial Capability Framework. Second Edition

    Science.gov (United States)

    Basic Skills Agency, 2006

    2006-01-01

    Both the Financial Services Authority and the Basic Skills Agency are committed to supporting those individuals and organisations working to improve the financial capability of themselves and others. The development of the National Strategy for Financial Capability, coordinated by the Financial Services Authority, and the commissioning of a…

  4. Technology support for military capability based acquisition

    CSIR Research Space (South Africa)

    Thaba, Mphahlela

    2017-05-01

    Full Text Available gap between capability planning and acquisition of product systems in the SANDF. (Thaba J et al, 2015). The need for decision support tools and technologies to assist capability planners to close this gap and make sound decisions has become more...

  5. Building Organisational Capability the Private Provider Way

    Science.gov (United States)

    Guthrie, Hugh

    2008-01-01

    Organisational capability is recognised as a key to organisational success. The combination of human capital (peoples' skills and knowledge), social capital (relationships between people) and organisational capital (the organisation's processes), is central to building an organisation's capability. This paper, presented at the 2008 annual…

  6. Capabilities of Universities in Achieving the Agricultural ...

    African Journals Online (AJOL)

    All (100%) the respondents had no capability in acquiring machines and equipment needed for teaching and conducting researches on climate change. Majority (85%) of the respondents had no capability in terms of human resource development with regards to climate change. Funding/manpower (0.657), organizational ...

  7. Current Capability of Atomic Structure Theory

    International Nuclear Information System (INIS)

    Kim, Yong Ki

    1993-01-01

    Current capability of atomic structure theory is reviewed, and advantages, disadvantages and major features of popular atomic structure codes described. Comparisons between theoretical and experimental data on transition energies and lifetimes of excited levels are presented to illustrate the current capability of atomic structure codes.

  8. Knowledge Perspectives on Advancing Dynamic Capability

    NARCIS (Netherlands)

    van Reijsen, J.

    2014-01-01

    Dynamic Capability is the organizational capacity to timely adapt to a changing market environment by reconfiguring resources and routines in order to stay competitive. Although dynamic capability is considered the Holy Grail of strategic management, a connection to the knowledge management domain

  9. National power grid simulation capability : need and issues

    Energy Technology Data Exchange (ETDEWEB)

    Petri, Mark C. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2009-06-02

    On December 9 and 10, 2008, the Department of Homeland Security (DHS) Science and Technology Directorate sponsored a national workshop at Argonne National Laboratory to explore the need for a comprehensive modeling and simulation capability for the national electric power grid system. The workshop brought together leading electric power grid experts from federal agencies, the national laboratories, and academia to discuss the current state of power grid science and engineering and to assess if important challenges are being met. The workshop helped delineate gaps between grid needs and current capabilities and identify issues that must be addressed if a solution is to be implemented. This report is a result of the workshop and highlights power grid modeling and simulation needs, the barriers that must be overcome to address them, and the benefits of a national power grid simulation capability.

  10. Using simulation to improve the capability of undergraduate nursing students in mental health care.

    Science.gov (United States)

    Kunst, Elicia L; Mitchell, Marion; Johnston, Amy N B

    2017-03-01

    Mental health care is an increasing component of acute patient care and yet mental health care education can be limited in undergraduate nursing programs. The aim of this study was to establish if simulation learning can be an effective method of improving undergraduate nurses' capability in mental health care in an acute care environment. Undergraduate nursing students at an Australian university were exposed to several high-fidelity high-technology simulation activities that incorporated elements of acute emergency nursing practice and acute mental health intervention, scaffolded by theories of learning. This approach provided a safe environment for students to experience clinical practice, and develop their skills for dealing with complex clinical challenges. Using a mixed method approach, the primary domains of interest in this study were student confidence, knowledge and ability. These were self-reported and assessed before and after the simulation activities (intervention) using a pre-validated survey, to gauge the self-rated capacity of students to initiate and complete effective care episodes. Focus group interviews were subsequently held with students who attended placement in the emergency department to explore the impact of the intervention on student performance in this clinical setting. Students who participated in the simulation activity identified and reported significantly increased confidence, knowledge and ability in mental health care post-intervention. They identified key features of the intervention included the impact of its realism on the quality of learning. There is some evidence to suggest that the intervention had an impact on the performance and reflection of students in the clinical setting. This study provides evidence to support the use of simulation to enhance student nurses' clinical capabilities in providing mental health care in acute care environments. Nursing curriculum development should be based on best-evidence to ensure that

  11. Capabilities and Equality of Health II

    DEFF Research Database (Denmark)

    Keiding, Hans

    The concept of capabilities, introduced originally by Sen, has inspired many researchers but has not found any simple formal representation which might be instrumental in the construction of a comprehensive theory of equality. In a previous paper (Keiding, 2005), we investigated whether preferences...... of the capability approach to questions of health or equality. In the present paper we extend the notion of rationalizing orderings of capabilities to a dynamical context, in the sense that the utility function is not yet revealed to the individual at the time when the capabilities are ordered. It turns out...... over capabilities as sets of functionings can be rationalized by maximization of a suitable utility function over the set of functionings. Such a rationalization turned out to be possible only in cases which must be considered exceptional and which do not allowfor interesting applications...

  12. The Advanced Test Reactor Irradiation Facilities and Capabilities

    International Nuclear Information System (INIS)

    S. Blaine Grover; Raymond V. Furstenau

    2007-01-01

    The Advanced Test Reactor (ATR) is one of the world's premiere test reactors for performing long term, high flux, and/or large volume irradiation test programs. The ATR is a very versatile facility with a wide variety of experimental test capabilities for providing the environment needed in an irradiation experiment. These different capabilities include passive sealed capsule experiments, instrumented and/or temperature-controlled experiments, and pressurized water loop experiment facilities. The ATR has enhanced capabilities in experiment monitoring and control systems for instrumented and/or temperature controlled experiments. The control systems utilize feedback from thermocouples in the experiment to provide a custom blended flowing inert gas mixture to control the temperature in the experiments. Monitoring systems have also been utilized on the exhaust gas lines from the experiment to monitor different parameters, such as fission gases for fuel experiments, during irradiation. ATR's unique control system provides axial flux profiles in the experiments, unperturbed by axially positioned control components, throughout each reactor operating cycle and over the duration of test programs requiring many years of irradiation. The ATR irradiation positions vary in diameter from 1.6 cm (0.625 inches) to 12.7 cm (5.0 inches) over an active core length of 122 cm (48.0 inches). Thermal and fast neutron fluxes can be adjusted radially across the core depending on the needs of individual test programs. This paper will discuss the different irradiation capabilities available and the cost/benefit issues related to each capability. Examples of different experiments will also be discussed to demonstrate the use of the capabilities and facilities at ATR for performing irradiation experiments

  13. New and Emerging Satellite Imaging Capabilities in Support of Safeguards

    International Nuclear Information System (INIS)

    Johnson, M.; Paquette, J.P.; Spyropoulos, N.; Rainville, L.; Schichor, P.; Hong, M.

    2015-01-01

    This abstract is focused on new and emerging commercial satellite imagery (CSI) capabilities. For more than a decade, experienced imagery analysts have been exploiting and analyzing CSI in support of the Department of Safeguards. As the remote sensing industry continues to evolve, additional CSI imagery types are becoming available that could enhance our ability to evaluate and verify States' declarations and to investigate the possible presence of undeclared activities. A newly available and promising CSI capability that may have a Safeguards application is Full Motion Video (FMV) imagery collection from satellites. For quite some time, FMV imagery has been collected from airborne platforms, but now FMV sensors are being deployed into space. Like its airborne counterpart, satellite FMV imagery could provide analysts with a great deal of information, including insight into the operational status of facilities and patterns of activity. From a Safeguards perspective, FMV imagery could help the Agency in the evaluation and verification of States' declared facilities and activities. There are advantages of FMV imaging capabilities that cannot be duplicated with other CSI capabilities, including the ability to loiter over areas of interest and the potential to revisit sites multiple times per day. Additional sensor capabilities applicable to the Safeguards mission include, but are not limited to, the following sensors: · Thermal Infrared imaging sensors will be launched in late 2014 to monitor operational status, e.g., heat from a transformer. · High resolution ShortWave Infrared sensors able to characterize materials that could support verification of Additional Protocol declarations under Article 2.a(v). · Unmanned Aerial Vehicles with individual sensors or specific sensor combinations. The Safeguards Symposium provides a forum to showcase and demonstrate safeguards applications for these emerging satellite imaging capabilities. (author)

  14. Investments by NASA to build planetary protection capability

    Science.gov (United States)

    Buxbaum, Karen; Conley, Catharine; Lin, Ying; Hayati, Samad

    NASA continues to invest in capabilities that will enable or enhance planetary protection planning and implementation for future missions. These investments are critical to the Mars Exploration Program and will be increasingly important as missions are planned for exploration of the outer planets and their icy moons. Since the last COSPAR Congress, there has been an opportunity to respond to the advice of NRC-PREVCOM and the analysis of the MEPAG Special Regions Science Analysis Group. This stimulated research into such things as expanded bioburden reduction options, modern molecular assays and genetic inventory capability, and approaches to understand or avoid recontamination of spacecraft parts and samples. Within NASA, a portfolio of PP research efforts has been supported through the NASA Office of Planetary Protection, the Mars Technology Program, and the Mars Program Office. The investment strategy focuses on technology investments designed to enable future missions and reduce their costs. In this presentation we will provide an update on research and development supported by NASA to enhance planetary protection capability. Copyright 2008 California Institute of Technology. Government sponsorship acknowledged.

  15. Analytical Chemistry Core Capability Assessment - Preliminary Report

    International Nuclear Information System (INIS)

    Barr, Mary E.; Farish, Thomas J.

    2012-01-01

    The concept of 'core capability' can be nebulous one. Even at a fairly specific level, where core capability equals maintaining essential services, it is highly dependent upon the perspective of the requestor. Samples are submitted to analytical services because the requesters do not have the capability to conduct adequate analyses themselves. Some requests are for general chemical information in support of R and D, process control, or process improvement. Many analyses, however, are part of a product certification package and must comply with higher-level customer quality assurance requirements. So which services are essential to that customer - just those for product certification? Does the customer also (indirectly) need services that support process control and improvement? And what is the timeframe? Capability is often expressed in terms of the currently utilized procedures, and most programmatic customers can only plan a few years out, at best. But should core capability consider the long term where new technologies, aging facilities, and personnel replacements must be considered? These questions, and a multitude of others, explain why attempts to gain long-term consensus on the definition of core capability have consistently failed. This preliminary report will not try to define core capability for any specific program or set of programs. Instead, it will try to address the underlying concerns that drive the desire to determine core capability. Essentially, programmatic customers want to be able to call upon analytical chemistry services to provide all the assays they need, and they don't want to pay for analytical chemistry services they don't currently use (or use infrequently). This report will focus on explaining how the current analytical capabilities and methods evolved to serve a variety of needs with a focus on why some analytes have multiple analytical techniques, and what determines the infrastructure for these analyses. This information will be

  16. Frequency support capability of variable speed wind turbine based on electromagnetic coupler

    DEFF Research Database (Denmark)

    You, Rui; Barahona Garzón, Braulio; Chai, Jianyun

    2015-01-01

    In the variable speed wind turbine based on electromagnetic coupler (WT-EMC), a synchronous generator is directly coupled with grid. So like conventional power plants WT-EMC is able to support grid frequency inherently. But due to the reduced inertia of synchronous generator, its frequency support...... capability has to be enhanced. In this paper, the frequency support capability of WT-EMC is studied at three typical wind conditions and with two control strategies-droop control and inertial control to enhance its frequency support capability. The synchronous generator speed, more stable than the grid...

  17. A strategic approach to developing e-learning capability for healthcare.

    Science.gov (United States)

    Clarke, Angie; Lewis, Dina; Cole, Ian; Ringrose, Liz

    2005-12-01

    This article examines a strategic approach to developing e-learning capability to enhance learning opportunities for the workforce of a healthcare organization. Emphasis is given to the procurement of a bespoke Managed Learning Environment (MLE). Strategic organizational issues impacting on future e-learning developments are considered. The 2-year implementation plan was evaluated through a two phase external research project. The first phase focused on the effectiveness of a training programme designed to build capacity for e-learning within the Northern area and also included a virtual learning environment usability study which informed the MLE specification. The second phase evaluation is ongoing during 2005 and interim findings are presented. The MLE has been piloted and on-line learning packages have been acquired. There has been a phased take-up of e-learning opportunities and e-tutor training. Some virtual Communities of Practice have been established. Key organizational issues have been identified and ongoing findings are informing strategic planning. The healthcare MLE is offering enhanced learning opportunities and assisting area healthcare providers in training their dispersed workforces. Blended learning strategies are most successful. The need for protected time for e-learning is a key issue, financial savings are available. Progress has been slowed by identified organizational constraints-the MLE's benefits are widely recognized.

  18. Does emotional memory enhancement assist the memory-impaired?

    Directory of Open Access Journals (Sweden)

    Lucas S. Broster

    2012-03-01

    Full Text Available We review recent work on emotional memory enhancement in older adults and patients with mild cognitive impairment or Alzheimer dementia and evaluate the viability of incorporating emotional components into cognitive rehabilitation for these groups. First, we identify converging evidence regarding the effects of emotional valence on working memory in healthy aging. Second, we introduce work that suggests a more complex role for emotional memory enhancement in aging and identify a model capable of unifying disparate research findings. Third, we identify neuroimaging evidence that the amygdala may play a key role in mediating emotional memory enhancement in mild cognitive impairment and early Alzheimer dementia. Finally, we assess the theoretical feasibility of incorporating emotional content into cognitive rehabilitation given all available evidence.

  19. Conceptualising energy use and energy poverty using a capabilities framework

    International Nuclear Information System (INIS)

    Day, Rosie; Walker, Gordon; Simcock, Neil

    2016-01-01

    In this article we conceptualise energy use from a capabilities perspective, informed by the work of Amartya Sen, Martha Nussbaum and others following them. Building on this, we suggest a corresponding definition of energy poverty, as understood in the capabilities space. We argue that such an understanding provides a theoretically coherent means of comprehending the relationship between energy and wellbeing, and thus conceptualising energy deprivation, that makes sense across settings including both the global North and South: a coherence which has previously been lacking. At the same time, it has the flexibility to be deployed in a way that is sensitive to local contexts. Understanding energy use in the capabilities space also provides a means for identifying multiple sites of intervention, including some areas that are currently largely overlooked. We argue that this is advantageous for attempts to address energy poverty in the context of climate change and imperatives for the containment of aggregate energy consumption. - Highlights: •We apply the capabilities approach of Amartya Sen and Martha Nussbaum to conceptualising why energy is used and needed. •We propose a definition of energy poverty based on the capabilities approach. •We argue that this understanding integrates approaches to energy poverty from global North and South contexts. •The proposed definition of energy poverty is multi-dimensional. •This understanding opens new conceptual space for interventions to alleviate energy poverty.

  20. Nuclear Research and Development Capabilities Needed to Support Future Growth

    Energy Technology Data Exchange (ETDEWEB)

    Wham, Robert M. [ORNL, P.O. Box 2008, Oak Ridge, TN 37831-6154 (United States); Kearns, Paul [Battelle Memorial Institute (United States); Marston, Ted [Marston Consulting (United States)

    2009-06-15

    The energy crisis looming before the United States can be resolved only by an approach that integrates a 'portfolio' of options. Nuclear energy, already an important element in the portfolio, should play an even more significant role in the future as the U.S. strives to attain energy independence and reduce carbon emissions. The DOE Office of Nuclear Energy asked Battelle Memorial Institute to obtain input from the commercial power generation industry on industry's vision for nuclear energy over the next 30-50 years. With this input, Battelle was asked to generate a set of research and development capabilities necessary for DOE to support the anticipated growth in nuclear power generation. This presentation, based on the report generated for the Office of Nuclear Energy, identifies the current and future nuclear research and development capabilities required to make this happen. The capabilities support: (1) continued, safe operation of the current fleet of nuclear plants; (2) the availability of a well qualified and trained workforce; (3) demonstration of the next generation nuclear plants; (4) development of a sustainable fuel cycle; (5) advanced technologies for maximizing resource utilization and minimization of waste and (6) advanced modeling and simulation for rapid and reliable development and deployment of new nuclear technologies. In order to assure these capabilities are made available, a Strategic Nuclear Energy Capability Initiative is proposed to provide the required resources during this critical period of time. (authors)

  1. Key Future Engineering Capabilities for Human Capital Retention

    Science.gov (United States)

    Sivich, Lorrie

    Projected record retirements of Baby Boomer generation engineers have been predicted to result in significant losses of mission-critical knowledge in space, national security, and future scientific ventures vital to high-technology corporations. No comprehensive review or analysis of engineering capabilities has been performed to identify threats related to the specific loss of mission-critical knowledge posed by the increasing retirement of tenured engineers. Archival data from a single diversified Fortune 500 aerospace manufacturing engineering company's engineering career database were analyzed to ascertain whether relationships linking future engineering capabilities, engineering disciplines, and years of engineering experience could be identified to define critical knowledge transfer models. Chi square, logistic, and linear regression analyses were used to map patterns of discipline-specific, mission-critical knowledge using archival data of engineers' perceptions of engineering capabilities, key developmental experiences, and knowledge learned from their engineering careers. The results from the study were used to document key engineering future capabilities. The results were then used to develop a proposed human capital retention plan to address specific key knowledge gaps of younger engineers as veteran engineers retire. The potential for social change from this study involves informing leaders of aerospace engineering corporations on how to build better quality mentoring or succession plans to fill the void of lost knowledge from retiring engineers. This plan can secure mission-critical knowledge for younger engineers for current and future product development and increased global competitiveness in the technology market.

  2. Hybrid Reality Lab Capabilities - Video 2

    Science.gov (United States)

    Delgado, Francisco J.; Noyes, Matthew

    2016-01-01

    Our Hybrid Reality and Advanced Operations Lab is developing incredibly realistic and immersive systems that could be used to provide training, support engineering analysis, and augment data collection for various human performance metrics at NASA. To get a better understanding of what Hybrid Reality is, let's go through the two most commonly known types of immersive realities: Virtual Reality, and Augmented Reality. Virtual Reality creates immersive scenes that are completely made up of digital information. This technology has been used to train astronauts at NASA, used during teleoperation of remote assets (arms, rovers, robots, etc.) and other activities. One challenge with Virtual Reality is that if you are using it for real time-applications (like landing an airplane) then the information used to create the virtual scenes can be old (i.e. visualized long after physical objects moved in the scene) and not accurate enough to land the airplane safely. This is where Augmented Reality comes in. Augmented Reality takes real-time environment information (from a camera, or see through window, and places digitally created information into the scene so that it matches with the video/glass information). Augmented Reality enhances real environment information collected with a live sensor or viewport (e.g. camera, window, etc.) with the information-rich visualization provided by Virtual Reality. Hybrid Reality takes Augmented Reality even further, by creating a higher level of immersion where interactivity can take place. Hybrid Reality takes Virtual Reality objects and a trackable, physical representation of those objects, places them in the same coordinate system, and allows people to interact with both objects' representations (virtual and physical) simultaneously. After a short period of adjustment, the individuals begin to interact with all the objects in the scene as if they were real-life objects. The ability to physically touch and interact with digitally created

  3. New capabilities of the lattice code WIMS-AECL

    International Nuclear Information System (INIS)

    Altiparmakov, Dimitar

    2008-01-01

    The lattice code WIMS-AECL has been restructured and rewritten in Fortran 95 in order to increase the accuracy of its responses and extend its capabilities. Significant changes of computing algorithms have been made in the following two areas: geometric calculations and resonance self-shielding. Among various geometry enhancements, the code is no longer restricted to deal with single lattice cell problems. The multi-cell capability allows modelling of various lattice structures such as checkerboard lattices, a de-fuelled channel, and core-reflector interface problems. The new resonance method performs distributed resonance self-shielding including the skin effect. This paper describes the main code changes and presents selected code verification results. (authors)

  4. Capability maturity models in engineering companies: case study analysis

    Directory of Open Access Journals (Sweden)

    Titov Sergei

    2016-01-01

    Full Text Available In the conditions of the current economic downturn engineering companies in Russia and worldwide are searching for new approaches and frameworks to improve their strategic position, increase the efficiency of the internal business processes and enhance the quality of the final products. Capability maturity models are well-known tools used by many foreign engineering companies to assess the productivity of the processes, to elaborate the program of business process improvement and to prioritize the efforts to optimize the whole company performance. The impact of capability maturity model implementation on cost and time are documented and analyzed in the existing research. However, the potential of maturity models as tools of quality management is less known. The article attempts to analyze the impact of CMM implementation on the quality issues. The research is based on a case study methodology and investigates the real life situation in a Russian engineering company.

  5. MTR fuel plate qualification capabilities at SCK-CEN

    International Nuclear Information System (INIS)

    Koonen, E.; Jacquet, P.

    2002-01-01

    In order to enhance the capabilities of BR2 in the field of MTR fuel plate testing, a dedicated irradiation device has been designed. In its basic version this device allows the irradiation of 3 fuel plates. The central fuel plate may be replaced by a dummy plate or a plate carrying dosimeters. A first FUTURE device has been built. A benchmark irradiation has been executed with standard BR2 fuel plates in order to qualify this device. Detailed neutronic calculations were performed and the results compared to the results of the post-irradiation examinations of the plates. These comparisons demonstrate the capability to conduct a fuel plate irradiation program under requested and well-known irradiation conditions. Further improvements are presently being designed in order to extend the ranges of heat flux and surface temperature of the fuel plates that can be handled with the FUTURE device. (author)

  6. Annunciation - building product team capabilities to support utility operational improvement

    International Nuclear Information System (INIS)

    Doucet, R.; Brown, R.; Trask, D.; Leger, R.; Mitchel, G.; Judd, R.; Davey, E.

    2003-01-01

    The purpose of this paper is to describe an AECL initiative to enhance the capabilities to assist utilities with undertaking annunciation improvement. This initiative was undertaken to complement a recent annunciation product upgrade, and in anticipation of developing commercial opportunities to assist Canadian and foreign utilities with control room annunciation improvement. Utilities are relying more and more on external engineering product and service providers to meet their plant support needs as they reduce in-house staffing to lower ongoing support costs. This evolving commercial environment places new demands on product and service providers, and provides new opportunities for increasing the proportion of product and service provider participation in plant improvement projects. This paper outlines recent AECL experience in the annunciation product area. The paper discusses the rationale for product support capability improvement, discusses the approaches undertaken, describes lessons learned, and outlines a proposed utility support model for assisting with future annunciation improvements. (author)

  7. Aviation security : TSA is enhancing its oversight of air carrier efforts to identify passengers on the No Fly and Selectee lists, but expects ultimate solution to be implementation of Secure Flight : report to congressional committees

    Science.gov (United States)

    2008-09-01

    Air carriers remain a front-line defense against acts of terrorism that target the nations civil aviation system. A key responsibility of air carriers is to check passengers names against terrorist watch-list records to identify persons who sho...

  8. What are the key organisational capabilities that facilitate research use in public health policy?

    Science.gov (United States)

    Huckel Schneider, Carmen; Campbell, Danielle; Milat, Andrew; Haynes, Abby; Quinn, Emma

    2014-11-28

    Literature about research use suggests that certain characteristics or capabilities may make policy agencies more evidence attuned. This study sought to determine policy makers' perceptions of a suite of organisational capabilities identified from the literature as potentially facilitating research uptake in policy decision making. A literature scan identified eight key organisational capabilities that support research use in policy making. To determine whether these capabilities were relevant, practical and applicable in real world policy settings, nine Australian health policy makers were consulted in September 2011. We used an open-ended questionnaire asking what facilitates the use of research in policy and program decision making, followed by specific questions rating the proposed capabilities. Interviews were transcribed and the content analysed. There was general agreement that the capabilities identified from the literature were relevant to real world contexts. However, interviewees varied in whether they could provide examples of experiences with the capabilities, how essential they considered the different capabilities to be and how difficult they considered the capabilities were to achieve. Efforts to improve the use of research in policy decision making are likely to benefit from targeting multiple organisational capabilities, including staff skills and competence, tools such as templates and checklists to aid evidence use and leadership support for the use of research in policy development. However, such efforts should be guided by an understanding of how policy agencies use evidence and how they view their roles, and external factors such as resource constraints and availability of appropriate research.

  9. The Impact of IT Capability on Employee Capability, Customer Value, Customer Satisfaction, and Business Performance

    Science.gov (United States)

    Chae, Ho-Chang

    2009-01-01

    This study empirically examines the impact of IT capability on firms' performance and evaluates whether firms' IT capabilities play a role in improving employee capability, customer value, customer satisfaction, and ultimately business performance. The results were based on comparing the business performance of the IT leader companies with that of…

  10. Annual Industrial Capabilities Report to Congress

    National Research Council Canada - National Science Library

    2006-01-01

    .... Stable robust Department of Defense (DoD) funding is the primary factor in sustaining those industrial capabilities supporting defense because such funding focuses market demand across a broad spectrum of industry segments to meet emerging...

  11. The Capabilities of the Offshore Middlemen

    DEFF Research Database (Denmark)

    Mahnke, Volker; Wareham, Jonathan

    preliminary theoretical justification for the emergence of offshore intermediaries; describe how and why they develop intermediation capabilities; and offer initial evidence substantiating their function and processes in intermediating transnational offshoring relationships in software development...

  12. [Run the risk: social disadvantage or capability?

    Science.gov (United States)

    Muñoz-Duque, Luz Adriana

    2018-05-10

    This article discusses the notions of risk and risk acceptability from a social justice perspective, especially in light of the capability approach proposed by Amartya Sen. The article argues that risk can be the expression of restrictions on subjects' capabilities, deriving from social disadvantages that can be taken for granted in their daily realities. On the other hand, risk can be viewed as an expression of capability in cases where subjects have accepted or admitted the risk through the exercise of freedom, as long as the subjects that relate to the risk do so in keeping with their idea of a good life, the building of which implies the full development of capability for agency. The article concludes with some thoughts on the issues of risk and risk acceptability in the sphere of public health.

  13. Building Airport Surface HITL Simulation Capability

    Science.gov (United States)

    Chinn, Fay Cherie

    2016-01-01

    FutureFlight Central is a high fidelity, real-time simulator designed to study surface operations and automation. As an air traffic control tower simulator, FFC allows stakeholders such as the FAA, controllers, pilots, airports, and airlines to develop and test advanced surface and terminal area concepts and automation including NextGen and beyond automation concepts and tools. These technologies will improve the safety, capacity and environmental issues facing the National Airspace system. FFC also has extensive video streaming capabilities, which combined with the 3-D database capability makes the facility ideal for any research needing an immersive virtual and or video environment. FutureFlight Central allows human in the loop testing which accommodates human interactions and errors giving a more complete picture than fast time simulations. This presentation describes FFCs capabilities and the components necessary to build an airport surface human in the loop simulation capability.

  14. Resistance capability of microaerobic granular sludge for ...

    African Journals Online (AJOL)

    enoh

    2012-02-08

    Feb 8, 2012 ... The resistance capability to pH shock of microaerobic granular sludge for pentachlorophenol (PCP) ... process with chlorine gas in pulp and paper, leather and spinning ... nitrifying bacteria in the aerobic zone, and then trans-.

  15. Establishing an infrared measurement and modelling capability

    CSIR Research Space (South Africa)

    Willers, CJ

    2011-04-01

    Full Text Available The protection of own aircraft assets against infrared missile threats requires a deep understanding of the vulnerability of these assets with regard to specific threats and specific environments of operation. A key capability in the protection...

  16. Bearding the Capability Deprivation Machine: The Pedagogical ...

    African Journals Online (AJOL)

    Bearding the Capability Deprivation Machine: The Pedagogical Deal for ... Africa are managing the task of higher education in an environment marked by poverty. ... are valuable in the full range of social spaces young South Africans inhabit.

  17. Geospatial Information System Capability Maturity Models

    Science.gov (United States)

    2017-06-01

    To explore how State departments of transportation (DOTs) evaluate geospatial tool applications and services within their own agencies, particularly their experiences using capability maturity models (CMMs) such as the Urban and Regional Information ...

  18. Assessing Contractor Capabilities for Streamlined Site Investigations

    Science.gov (United States)

    The purpose of this document is to familiarize and encourage brownfields decision makers to investigate and employ innovative methods for characterizing their sites, to assist brownfields decision makers in assessing contractors' capabilities.

  19. Demonstration of New OLAF Capabilities and Technologies

    Science.gov (United States)

    Kingston, C.; Palmer, E.; Stone, J.; Neese, C.; Mueller, B.

    2017-06-01

    Upgrades to the On-Line Archiving Facility (OLAF) PDS tool are leading to improved usability and additional functionality by integration of JavaScript web app frameworks. Also included is the capability to upload tabular data as CSV files.

  20. Perception Management: A Core IO Capability

    National Research Council Canada - National Science Library

    Zaman, Khyber

    2007-01-01

    This thesis postulates that in today's media environment, with adversaries skillfully using propaganda to skirt nations' resolve, Perception Management is key to military success and should be an Information Operations (IO) Core Capability...