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Sample records for ib ic sne

  1. The different progenitors of type Ib, Ic SNe, and of GRB

    CERN Document Server

    Georgy, Cyril; Walder, Rolf; Folini, Doris; Maeder, André

    2009-01-01

    We discuss the properties of the progenitors of core collapse SNe, as they can be deduced from rotating stellar models of single stars. The type of the SN progenitor was determined from the surface abundances at the pre-SN stage. The type of the SN event was obtained from the masses of hydrogen and helium ejected at the time of the core-collapse SN event. We find that the minimum amount of helium ejected by a core-collapse SN (of whatever type) is around 0.3 MSun. There is no difference between the WC and WO stars in the ejected masses of helium, CNO elements, and heavy elements. Also no difference is expected between the chemical composition of a WC star resulting from a normal or a homogeneous evolution. The progenitors of type Ib SNe are WNL, WNE, or less massive WC stars. Those of type Ic are WC and WO stars. WO stars are produced in a limited mass range (around 60 MSun) and only at low metallicity (for = ZSun. For the GRB rate, our models produce too large a number for such an event, even if we restrict ...

  2. A Radio Survey of Type Ib and Ic Supernovae: Searching for Engine Driven Supernovae

    CERN Document Server

    Berger, E; Frail, D A; Soderberg, A M

    2003-01-01

    The association of gamma-ray bursts (GRBs) and core-collapse supernovae (SNe) of Type Ib and Ic was motivated by the detection of SN 1998bw in the error box of GRB 980425 and the now-secure identification of a SN 1998bw-like event in the cosmological GRB 030329. The bright radio emission from SN 1998bw indicated that it possessed some of the unique attributes expected of GRBs, namely a large reservoir of energy in (mildly) relativistic ejecta and variable energy input. The two popular scenarios for the origin of SN 1998bw are a typical cosmological burst observed off-axis or a member of a new distinct class of supernova explosions (gSNe). In the former, about 0.5% of local Type Ib/c SNe are expected to be similar to SN1998bw; for the latter no such constraint exists. Motivated thus, we began a systematic program of radio observations of most reported Type Ib/c SNe accessible to the Very Large Array. Of the 33 SNe observed from late 1999 to the end of 2002 at most one is as bright as SN 1998bw. From this we co...

  3. INTEGRAL FIELD SPECTROSCOPY OF SUPERNOVA EXPLOSION SITES: CONSTRAINING THE MASS AND METALLICITY OF THE PROGENITORS. I. TYPE Ib AND Ic SUPERNOVAE

    Energy Technology Data Exchange (ETDEWEB)

    Kuncarayakti, Hanindyo; Maeda, Keiichi [Kavli Institute for the Physics and Mathematics of the Universe (WPI), Todai Institutes for Advanced Study, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8583 (Japan); Doi, Mamoru; Morokuma, Tomoki; Hashiba, Yasuhito [Institute of Astronomy, Graduate School of Science, The University of Tokyo, 2-21-1 Osawa, Mitaka, Tokyo 181-0015 (Japan); Aldering, Greg [Physics Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720 (United States); Arimoto, Nobuo [National Astronomical Observatory of Japan, 2-21-1 Osawa, Mitaka, Tokyo 181-0015 (Japan); Pereira, Rui [CNRS/IN2P3, Institut de Physique Nucleaire de Lyon, 4 Rue Enrico Fermi, F-69622 Villeurbanne Cedex (France); Usuda, Tomonori, E-mail: hanindyo.kuncarayakti@ipmu.jp [Subaru Telescope, National Astronomical Observatory of Japan, 650 North A' ohoku Place, Hilo, HI 96720 (United States)

    2013-08-01

    Integral field spectroscopy of 11 Type Ib/Ic supernova (SN Ib/Ic) explosion sites in nearby galaxies has been obtained using UH88/SNIFS and Gemini-N/GMOS. The use of integral field spectroscopy enables us to obtain both spatial and spectral information about the explosion site, enabling the identification of the parent stellar population of the SN progenitor star. The spectrum of the parent population provides metallicity determination via strong-line method and age estimation obtained via comparison with simple stellar population models. We adopt this information as the metallicity and age of the SN progenitor, under the assumption that it was coeval with the parent stellar population. The age of the star corresponds to its lifetime, which in turn gives the estimate of its initial mass. With this method we were able to determine both the metallicity and initial (zero-age main sequence) mass of the progenitor stars of SNe Ib and Ic. We found that on average SN Ic explosion sites are more metal-rich and younger than SN Ib sites. The initial mass of the progenitors derived from parent stellar population age suggests that SN Ic has more massive progenitors than SN Ib. In addition, we also found indication that some of our SN progenitors are less massive than {approx}25 M{sub Sun }, indicating that they may have been stars in a close binary system that have lost their outer envelope via binary interactions to produce SNe Ib/Ic, instead of single Wolf-Rayet stars. These findings support the current suggestions that both binary and single progenitor channels are in effect in producing SNe Ib/Ic. This work also demonstrates the power of integral field spectroscopy in investigating SN environments and active star-forming regions.

  4. Inferring supernova IIb/Ib/Ic ejecta properties from light curves and spectra: Correlations from radiative-transfer models

    CERN Document Server

    Dessart, Luc; Woosley, Stan; Livne, Eli; Waldman, Roni; Yoon, Sung-Chul; Langer, Norbert

    2016-01-01

    We present 1-D non-Local-Thermodynamic-Equilibrium time-dependent radiative-transfer simulations for a large grid of supernovae (SNe) IIb/Ib/Ic that result from the terminal explosion of the mass donor in a close-binary system. Our sample covers ejecta masses $M_{\\rm e}$ of 1.7$-$5.2M$_\\odot$, kinetic energies $E_{\\rm kin}$ of 0.6$-$5.0$\\times$10$^{51}$erg, and $^{56}$Ni masses of 0.05$-$0.30M$_\\odot$. We find a strong correlation between the $^{56}$Ni mass and the photometric properties at maximum, and between the rise time to bolometric maximum and the post-maximum decline rate. We confirm the small scatter in ($V-R$) at 10d past $R$-band maximum. The quantity $V_{\\rm m} \\equiv \\sqrt{2E_{\\rm kin}/M_{\\rm e}}$ is comparable to the Doppler velocity measured from HeI 5875\\AA\\ at maximum in SNe IIb/Ib, although some scatter arises from the uncertain level of chemical mixing. The OI7772\\AA\\ line may be used for SNe Ic, but the correspondence deteriorates with higher ejecta mass/energy. We identify a temporal reve...

  5. Radiative-transfer models for supernovae IIb/Ib/Ic from binary-star progenitors

    CERN Document Server

    Dessart, Luc; Woosley, Stan; Livne, Eli; Waldman, Roni; Yoon, Sung-Chul; Langer, Norbert

    2015-01-01

    We present 1-D non-Local-Thermodynamic-Equilibrium time-dependent radiative-transfer simulations for supernovae (SNe) of type IIb, Ib, and Ic that result from the terminal explosion of the mass donor in a close-binary system. Here, we select three ejecta with a total kinetic energy of ~1.2e51erg, but characterised by different ejecta masses (2-5Msun), composition, and chemical mixing. The type IIb/Ib models correspond to the progenitors that have retained their He-rich shell at the time of explosion. The type Ic model arises from a progenitor that has lost its helium shell, but retains 0.32Msun of helium in a CO-rich core of 5.11Msun. We discuss their photometric and spectroscopic properties during the first 2-3 months after explosion, and connect these to their progenitor and ejecta properties including chemical stratification. For these three models, Arnett's rule overestimates the 56Ni mass by ~50% while the procedure of Katz et al., based on an energy argument, yields a more reliable estimate. The presenc...

  6. Type Ib/c Supernovae with and without Gamma-Ray Bursts

    CERN Document Server

    Modjaz, Maryam

    2012-01-01

    While the connection between Long Gamma-Ray Bursts (GRBs) and Type Ib/c Supernovae (SNe Ib/c) from stripped stars has been well-established, one key outstanding question is what conditions and factors lead to each kind of explosion in massive stripped stars. One promising line of attack is to investigate what sets apart SNe Ib/c with GRBs from those without GRBs. Here, I briefly present two observational studies that probe the SN properties and the environmental metallicities of SNe Ib/c (specifically broad-lined SNe Ic) with and without GRBs. I present an analysis of expansion velocities based on published spectra and on the homogeneous spectroscopic CfA data set of over 70 SNe of Types IIb, Ib, Ic and Ic-bl, which triples the world supply of well-observed Stripped SNe. Moreover, I demonstrate that a meta-analysis of the three published SN Ib/c metallicity data sets, when including only values at the SN positions to probe natal oxygen abundances, indicates at very high significance that indeed SNe Ic erupt f...

  7. A new method for estimating the bolometric properties of Ibc SNe

    CERN Document Server

    Cano, Zach

    2013-01-01

    The bolometric properties (nickel mass, ejecta mass and kinetic energies) of 61 Ibc supernovae (SNe), including 20 Gamma-Ray Burst and X-Ray Flash (GRB/XRF), 19 Ib, 13 Ic and 9 Ic-BL (broad-lined) SNe are presented. All of the available $BVRI$ photometry in the literature have been collected and used in a new method that utilizes a template supernova (SN 1998bw) and an analytical model based on Arnett (1982) to accurately estimate the bolometric properties of each SN. A statistical analysis of the bolometric properties is then performed, where it is found that GRB/XRF SNe are the most energetic, and eject more mass (including nickel content) than Ib, Ic and Ic-BL SNe. The results are then compared to the existing progenitor models of Ibc SNe, where it is concluded that it is highly likely that at least two progenitor channels exist for producing a Ibc SN: most Ibc SNe arise via binary interactions, where the mass of the stellar progenitor is less than what is attributed to a Wolf Rayet star. Conversely, the p...

  8. Towards a better understanding of the evolution of Wolf-Rayet stars and Type Ib/Ic supernova progenitors

    Science.gov (United States)

    Yoon, Sung-Chul

    2017-10-01

    Hydrogen-deficient Wolf-Rayet (WR) stars are potential candidates of Type Ib/Ic supernova (SN Ib/Ic) progenitors and their evolution is governed by mass-loss. Stellar evolution models with the most popular prescription for WR mass-loss rates given by Nugis & Lamers have difficulties in explaining the luminosity distribution of WR stars of WC and WO types and the SN Ic progenitor properties. Here, we suggest some improvements in the WR mass-loss rate prescription and discuss its implications for the evolution of WR stars and SN Ib/Ic progenitors. Recent studies on Galactic WR stars clearly indicate that the mass-loss rates of WC stars are systematically higher than those of WNE stars for a given luminosity. The luminosity and initial metallicity dependences of WNE mass-loss rates are also significantly different from those of WC stars. These factors have not been adequately considered together in previous stellar evolution models. We also find that an overall increase of WR mass-loss rates by about 60 per cent compared to the empirical values obtained with a clumping factor of 10 is needed to explain the most faint WC/WO stars. This moderate increase with our new WR mass-loss rate prescription results in SN Ib/Ic progenitor models more consistent with observations than those given by the Nugis & Lamers prescription. In particular, our new models predict that the properties of SN Ib and SN Ic progenitors are distinctively different, rather than they form a continuous sequence.

  9. Core-collapse explosions of Wolf–Rayet stars and the connection to Type IIb/Ib/Ic supernovae

    NARCIS (Netherlands)

    Dessart, L.; Hillier, D.J.; Livne, E.; Yoon, S.C.; Woosley, S.E.; Waldman, R.; Langer, N.

    2011-01-01

    We present non-Local Thermodynamic Equilibrium (LTE) time-dependent radiative-transfer simulations of supernova (SN) IIb/Ib/Ic spectra and light curves, based on ∼1051 erg pistondriven ejecta, with and without 56Ni, produced from single and binary Wolf–Rayet (WR) stars evolved at solar and sub-solar

  10. Integral field spectroscopy of supernova explosion sites: constraining mass and metallicity of the progenitors - I. Type Ib and Ic supernovae

    CERN Document Server

    Kuncarayakti, Hanindyo; Aldering, Greg; Arimoto, Nobuo; Maeda, Keiichi; Morokuma, Tomoki; Pereira, Rui; Usuda, Tomonori; Hashiba, Yasuhito

    2013-01-01

    Integral field spectroscopy of 11 type-Ib/c supernova explosion sites in nearby galaxies has been obtained using UH88/SNIFS and Gemini-N/GMOS. The use of integral field spectroscopy enables us to obtain both spatial and spectral information of the explosion site, allowing the identification of the parent stellar population of the supernova progenitor star. The spectrum of the parent population provides metallicity determination via strong-line method and age estimation obtained via comparison with simple stellar population (SSP) models. We adopt this information as the metallicity and age of the supernova progenitor, under the assumption that it was coeval with the parent stellar population. The age of the star corresponds to its lifetime, which in turn gives the estimate of its initial mass. With this method we were able to determine both the metallicity and initial (ZAMS) mass of the progenitor stars of the type Ib and Ic supernovae. We found that on average SN Ic explosion sites are more metal-rich and you...

  11. Central domain of DivIB caps the C-terminal regions of the FtsL/DivIC coiled-coil rod.

    Science.gov (United States)

    Masson, Soizic; Kern, Thomas; Le Gouëllec, Audrey; Giustini, Cécile; Simorre, Jean-Pierre; Callow, Philip; Vernet, Thierry; Gabel, Frank; Zapun, André

    2009-10-02

    DivIB(FtsQ), FtsL, and DivIC(FtsB) are enigmatic membrane proteins that are central to the process of bacterial cell division. DivIB(FtsQ) is dispensable in specific conditions in some species, and appears to be absent in other bacterial species. The presence of FtsL and DivIC(FtsB) appears to be conserved despite very low sequence conservation. The three proteins form a complex at the division site, FtsL and DivIC(FtsB) being associated through their extracellular coiled-coil region. We report here structural investigations by NMR, small-angle neutron and x-ray scattering, and interaction studies by surface plasmon resonance, of the complex of DivIB, FtsL, and DivIC from Streptococcus pneumoniae, using soluble truncated forms of the proteins. We found that one side of the "bean"-shaped central beta-domain of DivIB interacts with the C-terminal regions of the dimer of FtsL and DivIC. This finding is corroborated by sequence comparisons across bacterial genomes. Indeed, DivIB is absent from species with shorter FtsL and DivIC proteins that have an extracellular domain consisting only of the coiled-coil segment without C-terminal conserved regions (Campylobacterales). We propose that the main role of the interaction of DivIB with FtsL and DivIC is to help the formation, or to stabilize, the coiled-coil of the latter proteins. The coiled-coil of FtsL and DivIC, itself or with transmembrane regions, could be free to interact with other partners.

  12. Early-time light curves of Type Ib/c supernovae from the SDSS-II Supernova Survey

    CERN Document Server

    Taddia, F; Leloudas, G; Stritzinger, M D; Valenti, S; Galbany, L; Kessler, R; Schneider, D P; Wheeler, J C

    2014-01-01

    We analyse the early-time optical light curves (LCs) of 20 Type Ib/c supernovae (SNe Ib/c) from the Sloan Digital Sky Survey (SDSS) SN survey II, aiming to study their properties as well as to derive their progenitor parameters. High-cadence, multi-band LCs are fitted with a functional model and the best-fit parameters are compared among the SN types. Bolometric LCs (BLCs) are constructed for the entire sample. We computed the black-body (BB) temperature (T_BB) and photospheric radius (R_ph) evolution for each SN via BB fits on the spectral energy distributions. In addition, the BLC properties are compared to model expectations. Complementing our sample with literature data, we find that SNe Ic and Ic-BL (broad-line) have shorter rise times than those of SNe Ib and IIb. \\Delta m_15 is similar among the different sub-types. SNe Ic appear brighter and bluer than SNe Ib, but this difference vanishes if we consider host galaxy extinction corrections based on colors. Our SNe have typical T_BB ~ 10000 K at peak, an...

  13. Analysis of Late--time Light Curves of Type IIb, Ib and Ic Supernovae

    CERN Document Server

    Wheeler, J Craig; Clocchiatti, A

    2014-01-01

    The shape of the light curve peak of radioactive-powered core-collapse "stripped-envelope," supernovae constrains the ejecta mass, nickel mass, and kinetic energy by the brightness and diffusion time for a given opacity and observed expansion velocity. Late-time light curves give constraints on the same parameters, given the gamma-ray opacity. Previous work has shown that the principal light curve peaks for SN IIb with small amounts of hydrogen and for hydrogen/helium-deficient SN Ib/c are often rather similar near maximum light, suggesting similar ejecta masses and kinetic energies, but that late-time light curves show a wide dispersion, suggesting a dispersion in ejecta masses and kinetic energies. It was also shown that SN IIb and SN Ib/c can have very similar late-time light curves, but different ejecta velocities demanding significantly different ejecta masses and kinetic energies. We revisit these topics by collecting and analyzing well-sampled single color and quasi-bolometric light curves from the lit...

  14. SNE Industrial Fieldbus Interface

    Science.gov (United States)

    Lucena, Angel; Raines, Matthew; Oostdyk, Rebecca; Mata, Carlos

    2011-01-01

    Programmable logic controllers (PLCs) have very limited diagnostic and no prognostic capabilities, while current smart sensor designs do not have the capability to communicate over Fieldbus networks. The aim is to interface smart sensors with PLCs so that health and status information, such as failure mode identification and measurement tolerance, can be communicated via an industrial Fieldbus such as ControlNet. The SNE Industrial Fieldbus Interface (SIFI) is an embedded device that acts as a communication module in a networked smart sensor. The purpose is to enable a smart sensor to communicate health and status information to other devices, such as PLCs, via an industrial Fieldbus networking protocol. The SNE (Smart Network Element) is attached to a commercial off-the-shelf Any bus-S interface module through the SIFI. Numerous Anybus-S modules are available, each one designed to interface with a specific Fieldbus. Development of the SIFI focused on communications using the ControlNet protocol, but any of the Anybus-S modules can be used. The SIFI communicates with the Any-bus module via a data buffer and mailbox system on the Anybus module, and supplies power to the module. The Anybus module transmits and receives data on the Fieldbus using the proper protocol. The SIFI is intended to be connected to other existing SNE modules in order to monitor the health and status of a transducer. The SIFI can also monitor aspects of its own health using an onboard watchdog timer and voltage monitors. The SIFI also has the hardware to drive a touchscreen LCD (liquid crystal display) unit for manual configuration and status monitoring.

  15. IBS Diet

    Science.gov (United States)

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  16. iPTF15dtg: a double-peaked Type Ic Supernova from a massive progenitor

    CERN Document Server

    Taddia, F; Sollerman, J; Corsi, A; Gal-Yam, A; Karamehmetoglu, E; Lunnan, R; Bue, B; Ergon, M; Kasliwal, M; Vreeswijk, P M; Wozniak, P R

    2016-01-01

    Type Ic supernovae (SNe Ic) arise from the core-collapse of H (and He) poor stars, which could be either single WR stars or lower-mass stars stripped of their envelope by a companion. Their light curves are radioactively powered and usually show a fast rise to peak ($\\sim$10-15 d), without any early (first few days) emission bumps (with the exception of broad-lined SNe Ic) as sometimes seen for other types of stripped-envelope SNe (e.g., Type IIb SN 1993J and Type Ib SN 2008D). We have studied iPTF15dtg, a spectroscopically normal SN Ic with an early excess in the optical light curves followed by a long ($\\sim$30 d) rise to the main peak. It is the first spectroscopically-normal double-peaked SN Ic observed. We aim to determine the properties of this explosion and of its progenitor star. Optical photometry and spectroscopy of iPTF15dtg was obtained with multiple telescopes. The resulting light curves and spectral sequence are analyzed and modelled with hydrodynamical and analytical models, with particular foc...

  17. Medications (for IBS)

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  18. Medications (for IBS)

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  1. The Spectral SN-GRB Connection: Systematic Spectral Comparisons between Type Ic Supernovae, broad-lined Type Ic Supernovae with and without Gamma-Ray Bursts

    CERN Document Server

    Modjaz, Maryam; Bianco, Federica B; Graur, Or

    2015-01-01

    We present the first systematic investigation of spectral properties of 17 Type Ic Supernovae (SNe Ic), 10 broad-lined SNe Ic (SNe Ic-bl) without observed Gamma-Ray Bursts (GRBs) and 10 SNe Ic-bl with GRBs (SN-GRBs) as a function of time in order to probe their explosion conditions and progenitors. We analyze a total of 396 spectra, which were drawn from published spectra of individual SNe as well as from the densely time-sampled spectra data of Modjaz et al. (2014). In order to quantify the diversity of the SN spectra as a function of SN subtype, we construct average spectra of SNe Ic, SNe Ic-bl without GRBs and SNe Ic-bl with GRBs, along with standard deviation and maximum deviation contours. We find that SN~1994I is not a typical SN Ic, in contrast to common belief, while the spectra of SN 1998bw/GRB 980425 are representative of mean spectra of SNe Ic-bl. We measure the ejecta absorption and width velocities (as traced by FeII 5169) and find that SNe Ic-bl with GRBs, on average, have quantifiably higher ab...

  2. Medications (for IBS)

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  7. SN 2010ay Is a Luminous and Broad-Lined Type Ic Supernova Within a Low-Metallicity Host Galaxy

    Science.gov (United States)

    Sanders, N. E.; Soderberg, A. M.; Valenti, S.; Foley, R. J.; Chornock, R.; Chomiuk, L.; Berger, E.; Smartt, S.; Hurley, K.; Barthelmy, S. D.; Levesque, E. M.; Narayan, G.; Botticella, M. T.; Briggs, M. S.; Connaughton, V.; Terada, Y.; Gehrels, N.; Golenetskii, S.; Mazets, E.; Cline, T.; von Kienlin, A.; Boynton, W.; Chambers, K. C.; Grav, T.; Heasley, J. N.

    2012-01-01

    We report on our serendipitous pre-discovery detection and follow-up observations of the broad-lined Type Ic supernova (SN Ic) 2010ay at z = 0.067 imaged by the Pan-STARRS1 3pi survey just approximately 4 days after explosion. The supernova (SN) had a peak luminosity, MR approx. -20.2 mag, significantly more luminous than known GRB-SNe and one of the most luminous SNe Ib/c ever discovered. The absorption velocity of SN 2010ay is v Si (is) approx. 19×10(exp 3) km s-1 at approximately 40 days after explosion, 2-5 times higher than other broad-lined SNe and similar to the GRB-SN 2010bh at comparable epochs. Moreover, the velocity declines approximately 2 times slower than other SNe Ic-BL and GRB-SNe. Assuming that the optical emission is powered by radioactive decay, the peak magnitude implies the synthesis of an unusually large mass of 56Ni, MNi = 0.9 solar mass. Applying scaling relations to the light curve, we estimate a total ejecta mass, Mej (is) approx. 4.7 solar mass, and total kinetic energy, EK (is) approx. 11 × 10(exp 51) erg. The ratio of MNi to Mej is approximately 2 times as large for SN 2010ay as typical GRB-SNe and may suggest an additional energy reservoir. The metallicity (log(O/H)PP04 + 12 = 8.19) of the explosion site within the host galaxy places SN 2010ay in the low-metallicity regime populated by GRB-SNe, and (is) approximately 0.5(0.2) dex lower than that typically measured for the host environments of normal (broad-lined) SNe Ic. We constrain any gamma-ray emission with E(gamma) (is) approximately less than 6 × 10(exp 48) erg (25-150 keV), and our deep radio follow-up observations with the Expanded Very Large Array rule out relativistic ejecta with energy E (is) approximately greater than 10(exp 48) erg. We therefore rule out the association of a relativistic outflow like those that accompanied SN 1998bw and traditional long-duration gamma-ray bursts (GRBs), but we place less-stringent constraints on a weak afterglow like that seen from XRF

  8. Post-Infectious IBS (IBS-PI)

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  9. A LUMINOUS AND FAST-EXPANDING TYPE Ib SUPERNOVA SN 2012au

    Energy Technology Data Exchange (ETDEWEB)

    Takaki, Katsutoshi; Fukazawa, Yasushi; Itoh, Ryosuke; Ueno, Issei; Ui, Takahiro; Urano, Takeshi [Department of Physical Science, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8526 (Japan); Kawabata, Koji S.; Akitaya, Hiroshi; Moritani, Yuki; Ohsugi, Takashi; Uemura, Makoto; Yoshida, Michitoshi [Hiroshima Astrophysical Science Center, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8526 (Japan); Yamanaka, Masayuki [Kwasan Observatory, Kyoto University, Ohmine-cho Kita Kazan, Yamashina-ku, Kyoto 607-8471 (Japan); Maeda, Keiichi; Nomoto, Ken' ichi [Kavli Institute for the Physics and Mathematics of the Universe (WPI), Todai Institutes for Advanced Study, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8583 (Japan); Tanaka, Masaomi [National Astronomical Observatory of Japan, 2-21-1 Osawa, Mitaka, Tokyo 181-8588 (Japan); Kinugasa, Kenzo [Nobeyama Radio Observatory, National Astronomical Observatory of Japan, 462-2 Nobeyama, Minamimaki, Nagano 384-1305 (Japan); Sasada, Mahito, E-mail: takaki@hep01.hepl.hiroshima-u.ac.jp [Department of Astronomy, Kyoto University, Kitashirakawa-Oiwake-cho, Sakyo-ku, Kyoto 606-8502 (Japan)

    2013-08-01

    We present a set of photometric and spectroscopic observations of a bright Type Ib supernova SN 2012au from -6 days until {approx} + 150 days after maximum. The shape of its early R-band light curve is similar to that of an average Type Ib/c supernova. The peak absolute magnitude is M{sub R} = -18.7 {+-} 0.2 mag, which suggests that this supernova belongs to a very luminous group among Type Ib supernovae. The line velocity of He I {lambda}5876 is about 15,000 km s{sup -1} around maximum, which is much faster than that in a typical Type Ib supernova. From the quasi-bolometric peak luminosity of (6.7 {+-} 1.3) Multiplication-Sign 10{sup 42} erg s{sup -1}, we estimate the {sup 56}Ni mass produced during the explosion as {approx}0.30 M{sub Sun }. We also give a rough constraint to the ejecta mass 5-7 M{sub Sun} and the kinetic energy (7-18) Multiplication-Sign 10{sup 51} erg. We find a weak correlation between the peak absolute magnitude and He I velocity among Type Ib SNe. The similarities to SN 1998bw in the density structure inferred from the light-curve model as well as the large peak bolometric luminosity suggest that SN 2012au had properties similar to energetic Type Ic supernovae.

  10. Introduction to IBS

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  11. Medications (for IBS)

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  12. Medications (for IBS)

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    Full Text Available ... and Symptoms Overview Recognizing Symptoms Diagnosis of IBS Pain in IBS IBS with Constipation Constipated Diarrhea IBS ... Treatment Working with Your Physician Understanding and Managing Pain in IBS IBS Symptom Treatments Treating IBS Pain ...

  13. Medications (for IBS)

    Medline Plus

    Full Text Available ... Pain IBS Global Treatments IBS Diet Low FODMAP Diet Complimentary or Alt Treatments Medications Psychological Treatments Online Studies News You Can Use Living With IBS Relationships and IBS Pregnancy and IBS Travel and IBS IBS Patients' Experience ...

  14. Medications (for IBS)

    Medline Plus

    Full Text Available ... IBS Awareness Month IBS Awareness Month Tips of the Day Art of IBS Gallery Contact Us About ... IBS Awareness Month IBS Awareness Month Tips of the Day Art of IBS Gallery Contact Us Medications ...

  15. Medications (for IBS)

    Science.gov (United States)

    ... IBS Pain IBS Global Treatments IBS Diet Low FODMAP Diet Complimentary or Alt Treatments Medications Psychological Treatments ... IBS Pain IBS Global Treatments IBS Diet Low FODMAP Diet Complimentary or Alt Treatments Medications Psychological Treatments ...

  16. IBS Treatment Options

    Science.gov (United States)

    ... IBS Pain IBS Global Treatments IBS Diet Low FODMAP Diet Complimentary or Alt Treatments Medications Psychological Treatments ... IBS Pain IBS Global Treatments IBS Diet Low FODMAP Diet Complimentary or Alt Treatments Medications Psychological Treatments ...

  17. Post-Infectious IBS (IBS-PI)

    Science.gov (United States)

    ... D) or mixed (IBS-M) subtype (alternating between diarrhea and constipation) of IBS. Fewer cases are reported in the constipation predominant (IBS-C) subtype of IBS. Who gets PI-IBS? Risk factors for PI-IBS include: The duration and severity ...

  18. Medications (for IBS)

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    Full Text Available ... Irritable Bowel Syndrome Symptom Diary Testing in IBS Changes You Should Not Ignore if You Have IBS Treatment Working with Your Physician Understanding and Managing Pain in IBS IBS Symptom Treatments Treating IBS ...

  19. Medications (for IBS)

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    Full Text Available ... Month IBS Awareness Month Tips of the Day Art of IBS Gallery Contact Us About IBS Twitter ... Month IBS Awareness Month Tips of the Day Art of IBS Gallery Contact Us Medications Details Medications ...

  20. Medications (for IBS)

    Medline Plus

    Full Text Available ... Month IBS Awareness Month Tips of the Day Art of IBS Gallery Contact Us About IBS Twitter ... Month IBS Awareness Month Tips of the Day Art of IBS Gallery Contact Us Medications Details Medications ...

  1. Terrestrial impact of the galactic historical SNe

    Science.gov (United States)

    Iyudin, A. F.

    2002-03-01

    Galactic supernovae (SNe) of the last millennium have left their signatures in many energy domains, with the optical being the best known due to the absence of astronomical instruments before the 17th century being more sophisticated than the human eye. Alongside with these records found in the scriptes of the ancient eastern and western astronomers, quite recently other signatures were recognised as valuable tracers of historical SNe, for example, different ionic and/or molecular depositions in the polar ice, radioactive isotopes depositions, and the /γ-ray emission from the radioactive 44Ti produced in the SN explosion. While the ice depositions are expected to be the result of the supernova flash in the UV and soft X-rays, the 60Fe radioactive isotope deposition into the deep-ocean ferromanganese crust is the result of direct isotope transfer by cosmic rays dust grains originating in the SN blast wave. These and other impacts of the galactic SNe are important from the point of view of their possible influence on the terrestrial environment. In this paper we consider known tracers of historical SNe and compare them to the proposed new tracer based on the atmospheric response to the galactic supernova emission in the UV and X-rays. In addition to using the 44Ti radioactive decay line photons for uncovering hidden galactic supernova remnants by imaging /γ-ray telescopes, all such tracers form an important complement to the historical SNe record.

  2. SNe Ia as a cosmological probe

    CERN Document Server

    Meng, Xiangcun; Han, Zhanwen

    2015-01-01

    Type Ia supernovae luminosities can be corrected to render them useful as standard candles able to probe the expansion history of the universe. This technique was successful applied to discover the present acceleration of the universe. As the number of SNe Ia observed at high redshift increases and analysis techniques are perfected, people aim to use this technique to probe the equation of state of the dark energy. Nevertheless, the nature of SNe Ia progenitors remains controversial and concerns persist about possible evolution effects that may be larger and harder to characterize than the more obvious statistical uncertainties.

  3. Medications (for IBS)

    Medline Plus

    Full Text Available ... Join eNewsletter Sidebar × MOBILE MENU About Us What is IBS? What is IBS? Facts About IBS Gut Bacteria and IBS ... Twitter Facebook YouTube Search Search ... About Us What is IBS? What is IBS? Facts About IBS Gut ...

  4. Medications (for IBS)

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    Full Text Available ... Contact Us About IBS Twitter Facebook YouTube Search Search ... About Us What is IBS? What is IBS? Facts About IBS Gut Bacteria and IBS IBS in Men Other Disorders Testing for IBS Signs and Symptoms Overview Recognizing Symptoms ...

  5. Detecting a Hot Companion to the Progenitor of the Type Ic Supernova 1994I in M51

    Science.gov (United States)

    Van Dyk, Schuyler

    2013-10-01

    Core-collapse supernovae {SNe} are the endpoints of the lives of massive stars {with initial mass > 8 solar masses}. We are reasonably confident that the progenitor stars for most hydrogen-rich Type II SNe are red supergiants, based in part on direct identifications with HST. However, the progenitors of the stripped-envelope He-rich Type Ib and He-poor Type Ic SNe have yet to be directly identified. These SNe are thought to arise from either single, high-mass stars in the Wolf-Rayet phase or, alternatively, from lower-mass stars in interacting binary systems. Both models can account for the required extensive envelope stripping. Until a progenitor is identified for these SN types, our best hope of testing these progenitor models is to detect the companion star to the progenitor, if the binary model holds. This star is predicted to be a hot supergiant. Therefore, it is best detected in the ultraviolet. The only SN which is sufficiently nearby and experienced low enough reddening to be a viable target for this detection is the SN Ic 1994I in M51. Furthermore, the SN was imaged by HST when it was still bright, so we can pinpoint its location. We therefore propose, as part of the UV Initiative in Cycle 21, to image the site in F275W and F336W to levels deep enough to significantly detect a putative progenitor companion, if it exists. The proposed observations will provide an important test of the binary progenitor hypothesis.

  6. Medications (for IBS)

    Medline Plus

    Full Text Available ... Month IBS Awareness Month Tips of the Day Art of IBS Gallery ... IBS Medications Probiotics and Antibiotics Pharmacologic, or drug, therapy is best used in irritable bowel syndrome (IBS) ...

  7. Medications (for IBS)

    Medline Plus

    Full Text Available ... with Diarrhea Nausea and IBS Bloating in IBS Sleep and Irritable Bowel Syndrome Gynecological Aspects of Irritable ... with Diarrhea Nausea and IBS Bloating in IBS Sleep and Irritable Bowel Syndrome Gynecological Aspects of Irritable ...

  8. Medications (for IBS)

    Medline Plus

    Full Text Available ... Treatments Medications Psychological Treatments Online Studies News You Can Use Living With IBS Relationships and IBS Pregnancy ... Treatments Medications Psychological Treatments Online Studies News You Can Use Living With IBS Relationships and IBS Pregnancy ...

  9. Medications (for IBS)

    Medline Plus

    Full Text Available ... with Diarrhea Nausea and IBS Bloating in IBS Sleep and Irritable Bowel Syndrome Gynecological Aspects of Irritable ... with Diarrhea Nausea and IBS Bloating in IBS Sleep and Irritable Bowel Syndrome Gynecological Aspects of Irritable ...

  10. iPTF15dtg: a double-peaked Type Ic supernova from a massive progenitor

    Science.gov (United States)

    Taddia, F.; Fremling, C.; Sollerman, J.; Corsi, A.; Gal-Yam, A.; Karamehmetoglu, E.; Lunnan, R.; Bue, B.; Ergon, M.; Kasliwal, M.; Vreeswijk, P. M.; Wozniak, P. R.

    2016-08-01

    Context. Type Ic supernovae (SNe Ic) arise from the core-collapse of H- (and He-) poor stars, which could either be single Wolf-Rayet (WR) stars or lower-mass stars stripped of their envelope by a companion. Their light curves are radioactively powered and usually show a fast rise to peak (~10-15 d), without any early (in the first few days) emission bumps (with the exception of broad-lined SNe Ic) as sometimes seen for other types of stripped-envelope SNe (e.g., Type IIb SN 1993J and Type Ib SN 2008D). Aims: We have studied iPTF15dtg, a spectroscopically normal SN Ic with an early excess in the optical light curves followed by a long (~30 d) rise to the main peak. It is the first spectroscopically-normal double-peaked SN Ic to be observed. Our aim is to determine the properties of this explosion and of its progenitor star. Methods: Optical photometry and spectroscopy of iPTF15dtg was obtained with multiple telescopes. The resulting light curves and spectral sequence are analyzed and modeled with hydrodynamical and analytical models, with particular focus on the early emission. Results: iPTF15dtg is a slow rising SN Ic, similar to SN 2011bm. Hydrodynamical modeling of the bolometric properties reveals a large ejecta mass (~10 M⊙) and strong 56Ni mixing. The luminous early emission can be reproduced if we account for the presence of an extended (≳500 R⊙), low-mass (≳0.045 M⊙) envelope around the progenitor star. Alternative scenarios for the early peak, such as the interaction with a companion, a shock-breakout (SBO) cooling tail from the progenitor surface, or a magnetar-driven SBO are not favored. Conclusions: The large ejecta mass and the presence of H- and He-free extended material around the star suggest that the progenitor of iPTF15dtg was a massive (≳35 M⊙) WR star that experienced strong mass loss.

  11. New approaches to SNe Ia progenitors

    CERN Document Server

    Ruiz-Lapuente, Pilar

    2014-01-01

    Although Type Ia supernovae (SNe Ia) are a major tool in cosmology and play a key role in the chemical evolution of galaxies, the nature of their progenitor systems (apart from the fact that they must be close binaries containing at least one white dwarf) remains largely unknown. In the last decade, considerable efforts have been made, both observationally and theoretically, to solve this problem. Observations have, however, revealed a previously unsuspected variety of events, ranging from very underluminous outbursts to clearly overluminous ones, and spanning a range well outside the peak luminosity--decline rate of the light curve relationship, used to make calibrated candles of the SNe Ia. On the theoretical side, new explosion scenarios, such as violent mergings of pairs of white dwarfs, have been explored. We review those recent developments, emphasizing the new observational findings, but also trying to tie them to the different scenarios and explosion mechanisms proposed thus far.

  12. SN 2010ay IS A LUMINOUS AND BROAD-LINED TYPE Ic SUPERNOVA WITHIN A LOW-METALLICITY HOST GALAXY

    Energy Technology Data Exchange (ETDEWEB)

    Sanders, N. E.; Soderberg, A. M.; Foley, R. J.; Chornock, R.; Chomiuk, L.; Berger, E. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Valenti, S.; Smartt, S.; Botticella, M. T. [Astrophysics Research Centre, School of Maths and Physics, Queen' s University, Belfast BT7 1NN (United Kingdom); Hurley, K. [Space Sciences Laboratory, University of California Berkeley, 7 Gauss Way, Berkeley, CA 94720 (United States); Barthelmy, S. D.; Gehrels, N.; Cline, T. [NASA Goddard Space Flight Center, Code 661, Greenbelt, MD 20771 (United States); Levesque, E. M. [CASA, Department of Astrophysical and Planetary Sciences, University of Colorado, 389-UCB, Boulder, CO 80309 (United States); Narayan, G. [Department of Physics, Harvard University, Cambridge, MA 02138 (United States); Briggs, M. S.; Connaughton, V. [CSPAR, University of Alabama in Huntsville, Huntsville, AL (United States); Terada, Y. [Department of Physics, Saitama University, Shimo-Okubo, Sakura-ku, Saitama-shi, Saitama 338-8570 (Japan); Golenetskii, S.; Mazets, E., E-mail: nsanders@cfa.harvard.edu [Ioffe Physico-Technical Institute, Laboratory for Experimental Astrophysics, 26 Polytekhnicheskaya, St. Petersburg 194021 (Russian Federation); and others

    2012-09-10

    We report on our serendipitous pre-discovery detection and follow-up observations of the broad-lined Type Ic supernova (SN Ic) 2010ay at z = 0.067 imaged by the Pan-STARRS1 3{pi} survey just {approx}4 days after explosion. The supernova (SN) had a peak luminosity, M{sub R} Almost-Equal-To -20.2 mag, significantly more luminous than known GRB-SNe and one of the most luminous SNe Ib/c ever discovered. The absorption velocity of SN 2010ay is v{sub Si} Almost-Equal-To 19 Multiplication-Sign 10{sup 3} km s{sup -1} at {approx}40 days after explosion, 2-5 times higher than other broad-lined SNe and similar to the GRB-SN 2010bh at comparable epochs. Moreover, the velocity declines {approx}2 times slower than other SNe Ic-BL and GRB-SNe. Assuming that the optical emission is powered by radioactive decay, the peak magnitude implies the synthesis of an unusually large mass of {sup 56}Ni, M{sub Ni} = 0.9 M{sub Sun }. Applying scaling relations to the light curve, we estimate a total ejecta mass, M{sub ej} Almost-Equal-To 4.7 M{sub Sun }, and total kinetic energy, E{sub K} Almost-Equal-To 11 Multiplication-Sign 10{sup 51} erg. The ratio of M{sub Ni} to M{sub ej} is {approx}2 times as large for SN 2010ay as typical GRB-SNe and may suggest an additional energy reservoir. The metallicity (log (O/H){sub PP04} + 12 = 8.19) of the explosion site within the host galaxy places SN 2010ay in the low-metallicity regime populated by GRB-SNe, and {approx}0.5(0.2) dex lower than that typically measured for the host environments of normal (broad-lined) SNe Ic. We constrain any gamma-ray emission with E{sub {gamma}} {approx}< 6 Multiplication-Sign 10{sup 48} erg (25-150 keV), and our deep radio follow-up observations with the Expanded Very Large Array rule out relativistic ejecta with energy E {approx}> 10{sup 48} erg. We therefore rule out the association of a relativistic outflow like those that accompanied SN 1998bw and traditional long-duration gamma-ray bursts (GRBs), but we place less

  13. Spectral modeling of Type II SNe

    Science.gov (United States)

    Dessart, Luc

    2015-08-01

    The red supergiant phase represents the final stage of evolution in the life of moderate mass (8-25Msun) massive stars. Hidden from view, the core changes considerably its structure, progressing through the advanced stages of nuclear burning, and eventually becomes degenerate. Upon reaching the Chandrasekhar mass, this Fe or ONeMg core collapses, leading to the formation of a proto neutron star. A type II supernova results if the shock that forms at core bounce, eventually wins over the envelope accretion and reaches the progenitor surface.The electromagnetic display of such core-collapse SNe starts with this shock breakout, and persists for months as the ejecta releases the energy deposited initially by the shock or continuously through radioactive decay. Over a timescale of weeks to months, the originally optically-thick ejecta thins out and turns nebular. SN radiation contains a wealth of information about the explosion physics (energy, explosive nucleosynthesis), the progenitor properties (structure and composition). Polarised radiation also offers signatures that can help constrain the morphology of the ejecta.In this talk, I will review the current status of type II SN spectral modelling, and emphasise that a proper solution requires a time dependent treatment of the radiative transfer problem. I will discuss the wealth of information that can be gleaned from spectra as well as light curves, from both the early times (photospheric phase) and late times (nebular phase). I will discuss the diversity of Type SNe properties and how they are related to the diversity of red supergiant stars from which they originate.SN radiation offers an alternate means of constraining the properties of red-supergiant stars. To wrap up, I will illustrate how SNe II-P can also be used as probes, for example to constrain the metallicity of their environment.

  14. Cervical Cancer Stage IB

    Science.gov (United States)

    ... hyphen, e.g. -historical Searches are case-insensitive Cervical Cancer Stage IB Add to My Pictures View /Download : ... 1613x1200 View Download Large: 3225x2400 View Download Title: Cervical Cancer Stage IB Description: Stage IB1 and IB2 cervical ...

  15. SNE's methodological basis - web-based software in entrepreneurial surveys

    DEFF Research Database (Denmark)

    Madsen, Henning

    This overhead based paper gives an introduction to the research methodology applied in the surveys carried out in the SNE-project.......This overhead based paper gives an introduction to the research methodology applied in the surveys carried out in the SNE-project....

  16. Searching for Hydrogen in Type Ib Supernovae

    CERN Document Server

    James, Spencer

    2010-01-01

    We present synthetic spectral fits of the typical Type Ib SN 1999dn and the Hydrogen Rich Ib SN 2000H using the generalized non-local thermodynamic equilibrium stellar atmospheres code \\phx. We fit model spectra to five epochs of SN 1999dn ranging from ten days pre-maximum light to 17 days post-maximum light and the two earliest epochs of SN 2000H available, maximum light and six days post-maximum. Our goal is to investigate the possibility of hydrogen in Type Ib Supernovae (SNe Ib), specifically a feature around 6200\\AA\\ which has previously been attributed to high velocity H-alpha. In earlier work on SN 1999dn we found the most plausible alternative to H-alpha to be a blend of Si II and Fe II lines which can be adjusted to fit by increasing the metallicity. Our models are simple; they assume a powerlaw density profile with radius, homologous expansion, and solar compositions. The helium core is produced by burning 4H --> He in order to conserve nucleon number. For models with hydrogen the outer skin of the ...

  17. IC Treatment: Surgical Procedures

    Science.gov (United States)

    ... Complicated IC Cases Promising IC Diagnostic Tests Wrong Diagnosis IC Treatment Guideline IC Treatments IC Diet & Self Management Physical Therapy Antidepressants Antihistamines Pentosan Polysulfate Sodium Bladder Instillations Immunosuppresants ...

  18. IC: Frequently Asked Questions

    Science.gov (United States)

    ... Complicated IC Cases Promising IC Diagnostic Tests Wrong Diagnosis IC Treatment Guideline IC Treatments IC Diet & Self Management Physical Therapy Antidepressants Antihistamines Pentosan Polysulfate Sodium Bladder Instillations Immunosuppresants ...

  19. IC Treatment: Antihistamines

    Science.gov (United States)

    ... Complicated IC Cases Promising IC Diagnostic Tests Wrong Diagnosis IC Treatment Guideline IC Treatments IC Diet & Self Management Physical Therapy Antidepressants Antihistamines Pentosan Polysulfate Sodium Bladder Instillations Immunosuppresants ...

  20. Men and IC

    Science.gov (United States)

    ... Complicated IC Cases Promising IC Diagnostic Tests Wrong Diagnosis IC Treatment Guideline IC Treatments IC Diet & Self Management Physical Therapy Antidepressants Antihistamines Pentosan Polysulfate Sodium Bladder Instillations Immunosuppresants ...

  1. General IC Symptoms

    Science.gov (United States)

    ... Complicated IC Cases Promising IC Diagnostic Tests Wrong Diagnosis IC Treatment Guideline IC Treatments IC Diet & Self Management Physical Therapy Antidepressants Antihistamines Pentosan Polysulfate Sodium Bladder Instillations Immunosuppresants ...

  2. Children and IC

    Science.gov (United States)

    ... Complicated IC Cases Promising IC Diagnostic Tests Wrong Diagnosis IC Treatment Guideline IC Treatments IC Diet & Self Management Physical Therapy Antidepressants Antihistamines Pentosan Polysulfate Sodium Bladder Instillations Immunosuppresants ...

  3. DISCOVERY OF TWO SUPERNOVAE IN THE NUCLEAR REGIONS OF THE LUMINOUS INFRARED GALAXY IC 883

    Energy Technology Data Exchange (ETDEWEB)

    Kankare, E.; Mattila, S.; Takalo, A. [Tuorla Observatory, Department of Physics and Astronomy, University of Turku, Vaeisaelaentie 20, FI-21500 Piikkioe (Finland); Ryder, S. [Australian Astronomical Observatory, P.O. Box 296, Epping, NSW 1710 (Australia); Vaeisaenen, P. [South African Astronomical Observatory, P.O. Box 9, Observatory 7935 (South Africa); Alberdi, A.; Perez-Torres, M.-A.; Romero-Canizales, C. [Instituto de Astrofsica de Andalucia, IAA-CSIC, Apartado 3004, 18080 Granada (Spain); Alonso-Herrero, A.; Colina, L. [Departamento de Astrofisica, Centro de Astrobiologia, CSIC/INTA, Carretera de Torrejon a Ajalvir, km 4, 28850, Torrejon de Ardoz, Madrid (Spain); Efstathiou, A. [School of Sciences, European University Cyprus, Diogenes Street, Engomi, 1516 Nicosia (Cyprus); Kotilainen, J. [Finnish Centre for Astronomy with ESO (FINCA), University of Turku, Vaeisaelaentie 20, FI-21500 Piikkioe (Finland); Melinder, J., E-mail: erkki.kankare@utu.fi [Department of Astronomy, Oskar Klein Centre, Stockholm University, AlbaNova University Centre, 106 91 Stockholm (Sweden)

    2012-01-10

    We report the discovery of two consecutive supernovae (SNe), 2010cu and 2011hi, located at 0.''37 (180 pc) and 0.''79 (380 pc) projected distance, respectively, from the center of the K-band nucleus of the luminous infrared galaxy (LIRG) IC 883. The SNe were discovered in an ongoing near-infrared K-band search for core-collapse SNe in such galaxies using the ALTAIR/NIRI adaptive optics system with laser guide star at the Gemini-North Telescope. These are thus the closest SNe yet discovered to an LIRG nucleus in optical or near-infrared wavelengths. The near-infrared light curves and colors of both SNe are consistent with core-collapse events. Both SNe seem to suffer from relatively low host galaxy extinction suggesting that regardless of their low projected galactocentric distances, they are not deeply buried in the nuclear regions of the host galaxy.

  4. Discovery of Two Supernovae in the Nuclear Regions of the Luminous Infrared Galaxy IC 883

    CERN Document Server

    Kankare, E; Ryder, S; Vaisanen, P; Alberdi, A; Alonso-Herrero, A; Colina, L; Efstathiou, A; Kotilainen, J; Melinder, J; Perez-Torres, M -A; Romero-Canizales, C; Takalo, A

    2011-01-01

    We report the discovery of two consecutive supernovae (SNe), 2010cu and 2011hi, located at 0.37" (180 pc) and 0.79" (380 pc) projected distance respectively from the centre of the K-band nucleus of the luminous infrared galaxy IC 883. The SNe were discovered in an ongoing near-infrared K-band search for core-collapse SNe in such galaxies using the ALTAIR/NIRI adaptive optics system with laser guide star at the Gemini-North Telescope. These are thus the closest SNe yet discovered to a LIRG nucleus in optical or near-infrared wavelengths. The near-infrared light curves and colours of both SNe are consistent with core-collapse events. Both SNe seem to suffer from relatively low host galaxy extinction suggesting that regardless of their low projected galactocentric distances, they are not deeply buried in the nuclear regions of the host galaxy.

  5. Sne, is og 35 graders kulde

    DEFF Research Database (Denmark)

    reagere på de forventede klimaændringer. Temarapporten består af tre indledende kapitler der sætter scenen for hele projektet og dets muligheder. Derefter følger en rækkecase-stories hvor vi behandler udvalgte elementer i økosystemet ud fra de 6-7 års data vi har indsamlet indtil nu. Det er ikke altid....... miljøovervågningen og forvaltningen af de levende ressourcer. Ib Johnsen, Peter J. Aastrup og Annelise Holstebroe takkes for kritisk gennemlæsning af manuskripterne. Også tak til Hadley Centre for Climate Prediction and Research og American Meteorological Society for tilladelse til reproduktion af illustrationerne...

  6. SNe Ia: Can Chandrasekhar Mass Explosions Reproduce the Observed Zoo?

    CERN Document Server

    Baron, E

    2014-01-01

    The question of the nature of the progenitor of Type Ia supernovae (SNe Ia) is important both for our detailed understanding of stellar evolution and for their use as cosmological probes of the dark energy. Much of the basic features of SNe Ia can be understood directly from the nuclear physics, a fact which Gerry would have appreciated. We present an overview of the current observational and theoretical situation and show that it not incompatible with most SNe Ia being the results of thermonuclear explosions near the Chandrasekhar mass.

  7. Medications (for IBS)

    Medline Plus

    Full Text Available ... Gynecological Aspects of Irritable Bowel Syndrome Symptom Diary Testing in IBS Changes You Should Not Ignore if ... IBS Medications Probiotics and Antibiotics Pharmacologic, or drug, therapy is best used in irritable bowel syndrome ( ...

  8. Medications (for IBS)

    Medline Plus

    Full Text Available ... by a physician who specializes in motility or stress-related gastrointestinal disorders. More complex medication regimens, and ... IBS Medications Probiotics and Antibiotics Psychological Treatments Understanding Stress Cognitive Behavioral Therapy Relaxation Techniques for IBS Take ...

  9. Medications (for IBS)

    Medline Plus

    Full Text Available ... Diet Complimentary or Alt Treatments Medications Psychological Treatments Online Studies News You Can Use Living With IBS ... Diet Complimentary or Alt Treatments Medications Psychological Treatments Online Studies News You Can Use Living With IBS ...

  10. Medications (for IBS)

    Medline Plus

    Full Text Available ... Agents Antidepressant Medications Newer IBS Medications Probiotics and Antibiotics Pharmacologic, or drug, therapy is best used in ... Agents Antidepressant Medications Newer IBS Medications Probiotics and ... Treatments Understanding Stress Cognitive Behavioral Therapy Relaxation ...

  11. Medications (for IBS)

    Medline Plus

    Full Text Available ... Agents Antidepressant Medications Newer IBS Medications Probiotics and Antibiotics Pharmacologic, or drug, therapy is best used in ... Agents Antidepressant Medications Newer IBS Medications Probiotics and Antibiotics Psychological Treatments Understanding Stress Cognitive Behavioral Therapy Relaxation ...

  12. Medications (for IBS)

    Medline Plus

    Full Text Available ... Agents Antidiarrheal Agents Antidepressant Medications Newer IBS Medications Probiotics and Antibiotics Pharmacologic, or drug, therapy is best ... Agents Antidiarrheal Agents Antidepressant Medications Newer IBS Medications ... Psychological Treatments Understanding Stress Cognitive Behavioral ...

  13. Relaxation Techniques to Manage IBS Symptoms

    Science.gov (United States)

    ... IBS Pain IBS Global Treatments IBS Diet Low FODMAP Diet Complimentary or Alt Treatments Medications Psychological Treatments ... IBS Pain IBS Global Treatments IBS Diet Low FODMAP Diet Complimentary or Alt Treatments Medications Psychological Treatments ...

  14. Solving the 56Ni puzzle of magnetar-powered broad-lined type Ic supernovae

    CERN Document Server

    Wang, Ling-Jun; Xu, Dong; Wang, Shan-Qin; Dai, Zi-Gao; Wu, Xue-Feng; Wei, Jian-Yan

    2016-01-01

    Broad-lined type Ic supernovae (SNe Ic-BL) are of great importance because their association with long-duration gamma-ray bursts (LGRBs) holds the key to deciphering the central engine of LGRBs, which refrains from being unveiled despite decades of investigation. Among the two popularly hypothesized types of central engine, i.e., black holes and strongly magnetized neutron stars (magnetars), there is mounting evidence that the central engine of GRB-associated SNe (GRB-SNe) is rapidly rotating magnetars. Theoretical analysis also suggests that magnetars could be the central engine of SNe Ic-BL. What puzzled the researchers is the fact that light curve modeling indicates that as much as 0.2-0.5 solar mass of 56Ni was synthesized during the explosion of the SNe Ic-BL, which is unfortunately in direct conflict with current state-of-the-art understanding of magnetar-powered 56Ni synthesis. Here we propose a dynamic model of magnetar-powered SNe to take into account the acceleration of the ejecta by the magnetar, a...

  15. The luminosity calibration of SNe Ia: present status.

    Science.gov (United States)

    Tammann, G. A.; Reindl, B.

    Blue supernovae of type Ia (SNe Ia) have become the most important objects in cosmology being of exceptionally uniform luminosity. Used as relative distance indicators they map deviations from pure Hubble flow and determine the cosmological constant Λ. Once their absolute magnitude is determined they provide the best estimate of the large-scale value of the Hubble constant H0. An HST project is reviewed where Cepheid distances are used for the luminosity calibration of SNe Ia. The mean luminosity of 8 SNe Ia is MB(max) = -19.47±0.07, MV(max) = -19.48±0.07, corresponding - after small corrections for second parameters - to H0(cosmic) = 59±5.

  16. IC Associated Conditions

    Science.gov (United States)

    ... likely than the general population to have systemic lupus erythematosus. More recent research has revealed that IC may ... Pain & IC Hunner’s Ulcers IC Flares Women & IC Pregnancy & IC Intimacy & ... Floor Dysfunction Pudendal Neuralgia Sjogren’s Syndrome Vulvodynia ...

  17. Pregnancy and IC

    Science.gov (United States)

    ... Profile Home About IC Women & IC Pregnancy & IC Pregnancy & IC How Pregnancy Affects IC Unfortunately, there is limited scientific data ... 2009 issue of the ICA Update . Planning Your Pregnancy Planning ahead for your pregnancy will let you: ...

  18. General IC Symptoms

    Science.gov (United States)

    ... IC Symptoms of IC General IC Symptoms General IC Symptoms Symptoms of interstitial cystitis (IC) differ from ... news and events. Please leave this field empty Interstitial Cystitis Association 7918 Jones Branch Drive, Suite 300 McLean, ...

  19. Solving the 56Ni Puzzle of Magnetar-powered Broad-lined Type IC Supernovae

    Science.gov (United States)

    Wang, Ling-Jun; Han, Yan-Hui; Xu, Dong; Wang, Shan-Qin; Dai, Zi-Gao; Wu, Xue-Feng; Wei, Jian-Yan

    2016-11-01

    Broad-lined Type Ic supernovae (SNe Ic-BL) are of great importance because their association with long-duration gamma-ray bursts (LGRBs) holds the key to deciphering the central engine of LGRBs, which refrains from being unveiled despite decades of investigation. Among the two popularly hypothesized types of central engine, i.e., black holes and strongly magnetized neutron stars (magnetars), there is mounting evidence that the central engine of GRB-associated SNe (GRB-SNe) is rapidly rotating magnetars. Theoretical analysis also suggests that magnetars could be the central engine of SNe Ic-BL. What puzzled the researchers is the fact that light-curve modeling indicates that as much as 0.2{--}0.5 {M}⊙ of 56Ni was synthesized during the explosion of the SNe Ic-BL, which is unfortunately in direct conflict with current state-of-the-art understanding of magnetar-powered 56Ni synthesis. Here we propose a dynamic model of magnetar-powered SNe to take into account the acceleration of the ejecta by the magnetar, as well as the thermalization of the injected energy. Assuming that the SN kinetic energy comes exclusively from the magnetar acceleration, we find that although a major fraction of the rotational energy of the magnetar is to accelerate the SN ejecta, a tiny fraction of this energy deposited as thermal energy of the ejecta is enough to reduce the needed 56Ni to 0.06 M ⊙ for both SN 1997ef and SN 2007ru. We therefore suggest that magnetars could power SNe Ic-BL in aspects both of energetics and of 56Ni synthesis.

  20. Medications (for IBS)

    Medline Plus

    Full Text Available ... be readily available over-the-counter, in a pharmacy or grocery store, or limited by prescription only. ... in treating IBS in multi-center, high quality clinical trials. These are prescription medications intended for specific ...

  1. Medications (for IBS)

    Medline Plus

    Full Text Available ... You? IFFGD is a nonprofit education and research organization. Our mission is to inform, assist, and support ... Our Mission Awareness Activities Advocacy Activities Research Leadership Industry Council Contact us IBS Treatment Working With Your ...

  2. Medications (for IBS)

    Medline Plus

    Full Text Available ... treatment of IBS symptoms is not linked to depression, but rather likely to effects on the brain ... to Do and What to Avoid Foods That Cause Cramping and Diarrhea Foods that Cause Gas and ...

  3. Medications (for IBS)

    Medline Plus

    Full Text Available ... Help You? IFFGD is a nonprofit education and research organization. Our mission is to inform, assist, and ... About IFFGD Our Mission Awareness Activities Advocacy Activities Research Leadership Industry Council Contact us IBS Treatment Working ...

  4. Hypnosis for IBS

    Science.gov (United States)

    ... CAM Practitioner Hypnosis for IBS Yoga Video: About Hypnosis Hypnosis has been shown to be an effective treatment ... of what happens both during and after the hypnosis session. The treatment is generally comfortable and also ...

  5. Medications (for IBS)

    Medline Plus

    Full Text Available ... Newer IBS Medications Probiotics and Antibiotics Pharmacologic, or drug, therapy is best used in irritable bowel syndrome ( ... limited by prescription only. It might be a drug or a supplement; manufactured or "natural." It might ...

  6. Medications (for IBS)

    Medline Plus

    Full Text Available ... depression, but rather likely to effects on the brain and the gut. Antidepressant medications can reduce the intensity of pain signals going from gut to brain. Read more about antidepressant medications. Newer IBS-Targeted ...

  7. Medications (for IBS)

    Medline Plus

    Full Text Available ... depression, but rather likely to effects on the brain and the gut. Antidepressant medications can reduce the intensity of pain signals going from gut to brain. Read more about antidepressant medications. Newer IBS-Targeted ...

  8. Medications (for IBS)

    Medline Plus

    Full Text Available ... Newer IBS Medications Probiotics and Antibiotics Pharmacologic, or drug, therapy is best used in irritable bowel syndrome ( ... limited by prescription only. It might be a drug or a supplement; manufactured or "natural." It might ...

  9. Medications (for IBS)

    Medline Plus

    Full Text Available ... to physician counseling and dietary manipulations. What's a medication? Anything you take for a therapeutic effect counts ... the drug package or on your prescription label. Medications for IBS First line treatment has traditionally been ...

  10. Hypnosis for IBS

    Science.gov (United States)

    ... CAM Practitioner Hypnosis for IBS Yoga Video: About Hypnosis Hypnosis has been shown to be an effective treatment ... of what happens both during and after the hypnosis session. The treatment is generally comfortable and also ...

  11. Twin Supernova Studies with SNe Ia from SNfactory

    Science.gov (United States)

    Fakhouri, Hannah; Aldering, G.; Aragon, C.; Hsiao, E.; Loken, S.; Nugent, P.; Perlmutter, S.; Runge, K.; Thomas, R. C.; Antilogous, P.; Bongard, S.; Canto, A.; Pain, R.; Wu, C.; Chotard, N.; Copin, Y.; Gangler, E.; Pereira, R.; Smadja, G.; Pecontal, E.; Baltay, C.; Rabinowitz, D.; Scalzo, R.; Buton, C.; Kerschhaggl, M.; Kowalski, M.; Paech, K.; Tao, C.

    2011-01-01

    We present a study of twin supernovae with spectrophotometric timeseries of nearby Type Ia supernova from the Nearby Supernova Factory (Aldering, et al. 2002). One advantage of "twins” is they offer the best opportunity for having objects with the same intrinsic luminosities and colors, ostensibly leaving only extrinsic factors such as dust to explain any observed differences in brightness and color. Using well-sampled timeseries data for over 100 nearby Hubble-flow SNe Ia, we study the impact of dust on the brightness differences of SN Ia twins in order to improve the standardization of these standardizable candles that have been and will continue to be a primary tool in the determination of cosmological parameters. Specifically we are able to solve for the relative extinction and RV needed to bring the twins into near-perfect agreement. We will present a study of the resulting distribution of RV. In searching for twin supernovae we have found groups of SNe, again differing only by a dust law that accounts for the brightness differences. These groups allow us to look for similarities in subsets of SNe and explore spectrophotometric differences from group to group.

  12. IC Treatment: Antidepressants

    Science.gov (United States)

    ... restrictions than MAOIs. Studies Testing Antidepressants to Treat IC With the exception of the TCA called amitriptyline ( ... when you have IC). Antidepressants Used to Treat IC Some of the current antidepressants your physician may ...

  13. Children and IC

    Science.gov (United States)

    ... well as his or her teachers, principal, school nurse, gym teacher, etc. Your child’s symptoms may be ... Out IC How to Schedule an IC Advocacy District Visit IC Advocates in Action Spur Research Funding ...

  14. Medications (for IBS)

    Medline Plus

    Full Text Available ... 168 by Anthony J. Lembo, MD, Instructor of Medicine, Harvard Medical School; Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, MA. Last modified on February 23, 2015 at 12:18:55 PM ... Selecting a CAM Practitioner Hypnosis for IBS ...

  15. Ib Andersens brugsgrafik

    DEFF Research Database (Denmark)

    Ejlers, Steen

    1980-01-01

    Ib Andersen (1907-1969) var kendt og elsket som tegner på Politiken igennem en menneskealder. Men han var sideløbende yderst produktiv som brugsgrafiker og han skabte en mængde plakater, bogomslag, emballager – og pengesedler – hvor der opstod en æstetisk merværdi i symbiosen af skrift og billede....

  16. SN 2010ay is a Luminous and Broad-lined Type Ic Supernova within a Low-metallicity Host Galaxy

    CERN Document Server

    Sanders, Nathan E; Valenti, S; Chomiuk, L; Berger, E; Smartt, S; Hurley, K; Barthelmy, S D; Chornock, R; Foley, R J; Levesque, E M; Narayan, G; Kirshner, R P; Botticella, M T; Briggs, M S; Connaughton, V; Terada, Y; Gehrels, N; Golenetskii, S; Mazets, E; Cline, T; von Kienlin, A; Boynton, W; Chambers, K C; Grav, T; Heasley, J N; Hodapp, K W; Jedicke, R; Kaiser, N; Kudritzki, R -P; Luppino, G A; Lupton, R H; Magnier, E A; Monet, D G; Morgan, J S; Onaka, P M; Price, P A; Stubbs, C W; Tonry, J L; Wainscoat, R J; Waterson, M F

    2011-01-01

    [abridged] We report on our serendipitous pre-discovery detection and detailed follow-up of the broad-lined Type Ic supernova SN 2010ay at z\\approx0.067 imaged by the Pan-STARRS1 3{\\pi} survey just \\sim3 days after explosion. We estimate the explosion date and the peak luminosity of the SN, MR\\approx-20.2 mag, significantly brighter than known GRB-SNe and one of the most luminous SNe Ic ever discovered. We measure the photospheric expansion velocity of the explosion, v_ph\\approx19.2x10^3 km/s at \\sim40 days after explosion. In comparison with other broad-lined SNe, the characteristic velocity of SN 2010ay is 2-5x higher and similar to the measurements for GRB-SNe at comparable epochs. Moreover the velocity declines two times slower than other SNe Ic-BL and GRB-SNe. Assuming that the optical emission is powered by radioactive decay, the peak magnitude implies the synthesis of an unusually large mass of 56 Ni, M_Ni=0.9+0.2 M_solar. Our modeling of the light-curve points to a total ejecta mass, Mej\\approx4.7M_so...

  17. Light Echoes and the Environments of SNe 2014J and 2016adj

    Science.gov (United States)

    Sugerman, Ben; Benge, A.; Bryan, G.; Joung, M.; Lawrence, S.; Mac Low, M.; Ostriker, J.; Peek, J.

    2016-08-01

    Light echoes are one of the most powerful and efficient probes of the structure and composition of dust in circumstellar and interstellar environments. Observations of light echoes provide exact three-dimensional (3-D) positions of dust while constraining its density, grain-size and chemical make-up. These can be used to study the evolutionary history of supernova (SN) progenitors, produce high-resolution maps of the structure and composition of interstellar media (ISM), and geometrically measure extragalactic distances. However, echoes pass through a given point only once, and only illuminate a thin slice of a complete structure at any given time, thus accomplishing meaningful science requires carefully-planned, repeated observations. The Type Ia SN 2014J in M82, and the core-collapse SN 2016adj in Cen A are both nearby (~3.5 Mpc), highly reddened (A_V=2-4 mags), and were reported within the last year to have produced resolved light echoes. With 12 orbits of HST and 2.4 hours of Spitzer follow-up observations proposed here, we will map out much more of the 3-D geometry and measure the dust properties of numerous independent structures within the ISM of the host galaxies, and map out or constrain the presence of circumstellar material around each SN. These results can be further used to investigate why the extinction toward SN 2014J (R_V=1.4) differs from Galactic values; measure the geometric distances to both host galaxies; constrain the progenitor properties; test competing models of Type Ib/IIb SNe; and benchmark whether echoes can help us understand galactic feedback, by comparing the actual structures they reveal to ISM simulations.

  18. IC Treatment: Surgical Procedures

    Science.gov (United States)

    ... IC Epidemiology (RICE) Study Boston Area Community Health (BACH) Survey ICA Pilot Research Program Funding Opportunities Clinical ... IC Epidemiology (RICE) Study Boston Area Community Health (BACH) Survey ICA Pilot Research Program Funding Opportunities Clinical ...

  19. IC Treatment: Antihistamines

    Science.gov (United States)

    ... IC Epidemiology (RICE) Study Boston Area Community Health (BACH) Survey ICA Pilot Research Program Funding Opportunities Clinical ... IC Epidemiology (RICE) Study Boston Area Community Health (BACH) Survey ICA Pilot Research Program Funding Opportunities Clinical ...

  20. Men and IC

    Science.gov (United States)

    ... IC Epidemiology (RICE) Study Boston Area Community Health (BACH) Survey ICA Pilot Research Program Funding Opportunities Clinical ... IC Epidemiology (RICE) Study Boston Area Community Health (BACH) Survey ICA Pilot Research Program Funding Opportunities Clinical ...

  1. IC: Frequently Asked Questions

    Science.gov (United States)

    ... IC Epidemiology (RICE) Study Boston Area Community Health (BACH) Survey ICA Pilot Research Program Funding Opportunities Clinical ... IC Epidemiology (RICE) Study Boston Area Community Health (BACH) Survey ICA Pilot Research Program Funding Opportunities Clinical ...

  2. Evidence for Magnetar Formation in Broad-lined Type Ic Supernovae 1998bw and 2002ap

    Science.gov (United States)

    Wang, L. J.; Yu, H.; Liu, L. D.; Wang, S. Q.; Han, Y. H.; Xu, D.; Dai, Z. G.; Qiu, Y. L.; Wei, J. Y.

    2017-03-01

    Broad-lined type Ic supernovae (SNe Ic-BL) are peculiar stellar explosions that are distinct from ordinary SNe. Some SNe Ic-BL are associated with long-duration (≳ 2 {{s}}) gamma-ray bursts (GRBs). Black holes and magnetars are two types of compact objects that are hypothesized to be central engines of GRBs. In spite of decades of investigations, no direct evidence for the formation of black holes or magnetars has yet been found for GRBs. Here we report the finding that the early peak (t≲ 50 {days}) and late-time (t≳ 300 {days}) slow decay displayed in the light curves of SNe 1998bw (associated with GRB 980425) and 2002ap (not GRB-associated) can be attributed to magnetar spin-down with an initial rotation period {P}0∼ 20 {ms}, while the intermediate-time (50≲ t≲ 300 {days}) exponential decline is caused by the radioactive decay of 56Ni. The connection between the early peak and late-time slow decline in the light curves is unexpected in alternative models. We thus suggest that GRB 980425 and SN 2002ap were powered by magnetars.

  3. Evidence for magnetar formation in broad-lined type Ic supernovae 1998bw and 2002ap

    CERN Document Server

    Wang, L J; Liu, L D; Wang, S Q; Han, Y H; Xu, D; Dai, Z G; Qiu, Y L; Wei, J Y

    2016-01-01

    Broad-lined type Ic supernovae (SNe Ic-BL) are peculiar stellar explosions that distinguish themselves from ordinary SNe. Some SNe Ic-BL are associated with long-duration (\\gtrsim 2 s) gamma-ray bursts (GRBs). Black holes and magnetars are two types of compact objects that are hypothesized to be central engines of GRBs. In spite of decades of investigations, no direct evidence for the formation of black holes or magnetars has been found for GRBs so far. Here we report the discovery that the early peak (t \\lesssim 50 days) and late-time (t \\gtrsim 300 days) slow decay displayed in the light curves of both SNe 1998bw (associated with GRB 980425) and 2002ap (not GRB-associated) can be attributed to magnetar spin-down with initial rotation period P0 \\sim 20 ms, while the intermediate-time (50 \\lesssim t \\lesssim 300 days) linear decline is caused by radioactive decay of 56Ni. The connection between the early peak and late-time slow decline in the light curves is unexpected in alternative models. We thus suggest t...

  4. Testing SNe Ia distance measurement methods with SN 2011fe

    CERN Document Server

    Vinko, J; Takats, K; Marion, G H; Hegedus, T; Biro, I B; Borkovits, T; Szegedi-Elek, E; Farkas, A; Klagyivik, P; Kiss, L L; Kovacs, T; Pal, A; Szakats, R; Szalai, N; Szalai, T; Szatmary, K; Szing, A; Vida, K; Wheeler, J C

    2012-01-01

    The nearby, bright, almost completely unreddened Type Ia supernova 2011fe in M101 provides a unique opportunity to test both the precision and the accuracy of the extragalactic distances derived from SNe Ia light curve fitters. We apply the current, public versions of the independent light curve fitting codes MLCS2k2 and SALT2 to compute the true distance modulus of SN 2011fe from high-precision, multi-color (BVRI) light curves. The results from the two fitting codes confirm that 2011fe is a "normal" (not peculiar) and only slightly reddened SN Ia. New unreddened distance moduli are derived as 29.21 +/- 0.07 mag (D \\sim 6.95 +/- 0.23 Mpc, MLCS2k2), and 29.05 +/- 0.07 mag (6.46 +/- 0.21 Mpc, SALT2). Despite the very good fitting quality achieved with both light curve fitters, the resulting distance moduli are inconsistent by 2 sigma. However, both are marginally consistent (at \\sim 1 sigma) with the HST Key Project distance modulus for M101. The SALT2 distance is in good agreement with the recently revised Cep...

  5. The radial distribution of SNe in nuclear starbursts

    Science.gov (United States)

    Herrero-Illana, R.; Pérez-Torres, M. Á.; Alberdi, A.

    2012-10-01

    We have probed the radial distribution of supernovae and supernova remnants in the nuclear regions of the starburst galaxies M82, Arp 299-A, and Arp 220, by using high-angular resolution (≤ 0."1) radio observations. We derived scale-length values for the putative nuclear disks, which range from ~20-30 pc for Arp 299-A and Arp 220, up to ~140 pc for M82. The radial distribution of SNe for the nuclear disks in Arp 299-A and Arp 220 is also consistent with a power-law surface density profile of exponent γ = 1, as expected from detailed hydrodynamical simulations of nuclear disks. Our results give thus support to scenarios where a nuclear disk of size ~100 pc is formed in (U)LIRGs, and is sustained by gas pressure, in which case the accretion onto the black hole could be lowered due to supernova feedback. This study is detailed in Herrero-Illana et al. (2012). Database: ast

  6. Continuous Dust Formation in SNe 2010jl and 2011ja

    Science.gov (United States)

    Krafton, Kelsie; Clayton, Geoffrey; Andrews, Jennifer; Barlow, Michael; De Looze, Ilse

    2016-08-01

    Studies in the last 10 years of dust formation in core-collapse supernovae (CCSNe) have found only small amounts, ~0.001 solar masses. This is far less than the amount needed to account for the large masses of dust seen in some high redshift galaxies. However, the recent discovery of ~1 solar mass of cold dust in the ejecta of SN 1987A has has caused a complete re-evaluation of dust formation in CCSNe. It has been suggested that the CCSNe are continuously forming dust so that by the time they are about 25 years old they will have dust masses similar to SN 1987A. However, there is a wide time gap between the CCSNe that have been studied recently and SN 1987A. We plan to use the sensitivity of Spitzer to detect dust emission from CCSNe 5 or more years after explosion. Radiative transfer models will be used to estimate the dust masses. This proposal is to continue our study of two interesting SNe 2010jl and 2011ja. These observations are part of a long term study requiring multiple epochs of Spitzer observations to look for evidence of continuous dust formation. These observations will help shed light on the mystery of dust in SN 1987A.

  7. [Effect of polycarbophil Ca on IBS].

    Science.gov (United States)

    Mine, Tetsuya

    2006-08-01

    In this chapter, I mentioned the effect of polycarbophil Ca on IBS. IBS is classified into 3 types; diarrhea type, constipation type and combined type. Polycarbophil Ca is effective for all types of IBS.

  8. Relaxation Techniques to Manage IBS Symptoms

    Science.gov (United States)

    ... the Day Art of IBS Gallery Contact Us Relaxation Techniques to Manage IBS Symptoms Details Content Last Updated: ... Topic Psychological Treatments Understanding Stress Cognitive Behavioral Therapy Relaxation Techniques for IBS You’ve been to the doctor ...

  9. A Luminous and Fast-Expanding Type Ib Supernova SN 2012au

    CERN Document Server

    Takaki, K; Yamanaka, M; Maeda, K; Tanaka, M; Akitaya, H; Fukazawa, Y; Itoh, R; Kinugasa, K; Moritani, Y; Ohsugi, T; Sasada, M; Uemura, M; Ueno, I; Ui, T; Urano, T; Yoshida, M; Nomoto, K

    2013-01-01

    We present a set of photometric and spectroscopic observations of a bright Type Ib supernova SN 2012au from -6d until ~+150d after maximum. The shape of its early R-band light curve is similar to that of an average Type Ib/c supernova. The peak absolute magnitude is M_R=-18.7+-0.2 mag, which suggests that this supernova belongs to a very luminous group among Type Ib supernovae. The line velocity of He I {\\lambda}5876 is about 15,000 km/s around maximum, which is much faster than that in a typical Type Ib supernova. From the quasi-bolometric peak luminosity of (6.7+-1.3)x10^(42) erg/s, we estimate the \\Ni mass produced during the explosion as ~0.30 Msun. We also give a rough constraint to the ejecta mass 5-7 Msun and the kinetic energy (7-18)x10^(51) erg. We find a weak correlation between the peak absolute magnitude and He I velocity among Type Ib SNe. The similarities to SN 1998bw in the density structure inferred from the light curve model as well as the large peak bolometric luminosity suggest that SN 2012...

  10. The beauty of resolution: The SN Ib factory NGC 2770 spatially resolved

    Science.gov (United States)

    Thöne, C. C.; Christensen, L.; Gorosabel, J.; de Ugarte Postigo, A.

    2015-02-01

    The late-type spiral NGC 2770 hosted 3 Type Ib supernovae (SNe) in or next to star-forming regions in its outer spiral arms. We study the properties of the SN sites and the galaxy at different spatial resolutions to infer propeties of the SN progenitors and the SF history of the galaxy. Several 3D techniques are used and, for the first time, we present images of metallicity, shocks and stellar population ages from OSIRIS/GTC imaging with tunable narrowband filters.

  11. The initial and final state of SNe Ia from the single degenerate model

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Although type Ia supernovae(SNe Ia) show their importance in many astrophysical fields,the nature of the progenitors of SNe Ia is still unclear.At present,the single degenerate(SD) model is presented to be a very likely progenitor model.Following the comprehensive SD model developed by Meng & Yang(2010),we show the initial and final state of the progenitor systems of SNe Ia in an orbital period—the secondary mass(log Pi,M2i) plane.Our results may explain the location of some supersoft X-ray sources and recurrent novae in the(log Pi,M2i) plane,and be helpful to judge whether an SD system is the potential progenitor system of SNe Ia,as well as to simulate the interaction between SN ejecta and its companion.

  12. IC Associated Conditions

    Science.gov (United States)

    ... Bowel Syndrome Lupus Pelvic Floor Dysfunction Pudendal Neuralgia Sjogren’s Syndrome Vulvodynia Newly Diagnosed Toolkit IC Awareness Toolkit Know ... Bowel Syndrome Lupus Pelvic Floor Dysfunction Pudendal Neuralgia Sjogren’s Syndrome Vulvodynia Click to learn more about these and ...

  13. LD to IC

    CERN Multimedia

    Association du personnel

    2010-01-01

    LC to IC – Publication of posts: Following the publication of new LD to IC posts, we regret that a large number of post descriptions are not available in both CERN official languages, English and French. Consequently, the Staff Association has decided to provide assistance to those who need it with the translation of one or more posts of interest. To do this, please contact the Staff Association secretariat, tel. 72819 or 72761 or 74224.

  14. Tension between SNeIa and BAO: current status and future forecasts

    Energy Technology Data Exchange (ETDEWEB)

    Escamilla-Rivera, Celia [Astrophysics, University of Oxford, DWD, Kebble Road, Oxford, OX1 3RH (United Kingdom); Lazkoz, Ruth; Salzano, Vincenzo; Sendra, Irene, E-mail: celia_escamilla@ehu.es, E-mail: ruth.lazkoz@ehu.es, E-mail: vincenzo.salzano@ehu.es, E-mail: irene.sendra@ehu.es [Fisika Teorikoaren eta Zientziaren Historia Saila, Zientzia eta Teknologia Fakultatea, Euskal Herriko Unibertsitatea, 644 Posta Kutxatila, 48080 Bilbao (Spain)

    2011-09-01

    Using real and synthetic Type Ia SNe (SNeIa) and baryon acoustic oscillations (BAO) data representing current observations forecasts, this paper investigates the tension between those probes in the dark energy equation of state (EoS) reconstruction considering the well known CPL model and Wang's low correlation reformulation. In particular, here we present simulations of BAO data from both the the radial and transverse directions. We also explore the influence of priors on Ω{sub m} and Ω{sub b} on the tension issue, by considering 1σ deviations in either one or both of them. Our results indicate that for some priors there is no tension between a single dataset (either SNeIa or BAO) and their combination (SNeIa+BAO). Our criterion to discern the existence of tension (σ-distance) is also useful to establish which is the dataset with most constraining power; in this respect SNeIa and BAO data switch roles when current and future data are considered, as forecasts predict and spectacular quality improvement on BAO data. We also find that the results on the tension are blind to the way the CPL model is addressed: there is a perfect match between the original formulation and that by the correlation optimized proposed in Wang (2008), but the errors on the parameters are much narrower in all cases of our exhaustive exploration, thus serving the purpose of stressing the convenience of this reparametrization.

  15. THE BIRTH RATE OF SNe Ia FROM HYBRID CONe WHITE DWARFS

    Energy Technology Data Exchange (ETDEWEB)

    Meng, Xiangcun [Yunnan Observatories, Chinese Academy of Sciences, Kunming 650011 (China); Podsiadlowski, Philipp, E-mail: xiangcunmeng@ynao.ac.cn [Department of Astronomy, Oxford University, Oxford OX1 3RH (United Kingdom)

    2014-07-10

    Considering the uncertainties of the C-burning rate (CBR) and the treatment of convective boundaries, Chen et al. found that there is a regime where it is possible to form hybrid CONe white dwarfs (WDs), i.e., ONe WDs with carbon-rich cores. As these hybrid WDs can be as massive as 1.30 M {sub ☉}, not much mass needs to be accreted for these objects to reach the Chandrasekhar limit and to explode as Type Ia supernovae (SNe Ia). We have investigated their contribution to the overall SN Ia birth rate and found that such SNe Ia tend to be relatively young with typical time delays between 0.1 and 1 Gyr, where some may be as young as 30 Myr. SNe Ia from hybrid CONe WDs may contribute several percent to all SNe Ia, depending on the common-envelope ejection efficiency and the CBR. We suggest that these SNe Ia may produce part of the 2002cx-like SN Ia class.

  16. SNe Ia host galaxy properties from Sloan Digital Sky Survey-II spectroscopy

    CERN Document Server

    Johansson, Jonas; Pforr, Janine; Maraston, Claudia; Nichol, Robert C; Smith, Mathew; Lampeitl, Hubert; Beifiori, Alessandra; Gupta, Ravi R; Schneider, Donald P

    2012-01-01

    We study the stellar populations of SNe Ia host galaxies using SDSS-II spectroscopy. We focus on the relationships of SNe Ia properties with stellar velocity dispersion and the stellar population parameters age, metallicity and element abundance ratios derived by fitting absorption line indices to stellar population models. We concentrate on a sub-sample of 84 SNe Ia from the SDSS-II Supernova Survey. In agreement with previous findings, we find that SALT2 stretch factor values show the strongest dependence on stellar population age. Hence, SNe Ia peak-luminosity is closely related to the age of the stellar progenitor systems, where more luminous SNe Ia appear in younger stellar populations. We find no statistically significant trends in the Hubble residual with any of the stellar population parameters studied, including age and metallicity contrary to the literature, as well as with stellar velocity dispersion. Moreover, we find that the method of stellar mass derivation is affecting the Hubble residual-mass...

  17. The birth rate of SNe Ia from hybrid CONe white dwarfs

    CERN Document Server

    Meng, Xiangcun

    2014-01-01

    Considering the uncertainties of the C-burning rate (CBR) and the treatment of convective boundaries, Chen et al. (2014) found that there is a regime where it is possible to form hybrid CONe white dwarfs (WDs), i.e. ONe WDs with carbon-rich cores. As these hybrid WDs can be as massive as 1.30 $M_{\\odot}$, not much mass needs to be accreted for these objects to reach the Chandrasekhar limit and to explode as Type Ia supernovae (SNe Ia). We have investigated their contribution to the overall SN Ia birth rate and found that such SNe Ia tend to be relatively young with typical time delays between 0.1 and 1 Gyr, where some may be as young as 30 Myr. SNe Ia from hybrid CONe WDs may contribute several percent to all SNe Ia, depending on the common-envelope ejection efficiency and the CBR. We suggest that these SNe Ia may produce part of the 2002cx-like SN Ia class.

  18. IBS and Non-GI Functional Disorders

    Science.gov (United States)

    ... of IBS Gallery Contact Us IBS and Non-GI Functional Disorders Details Other Disorders Last Updated: 08 ... many examples of functional disorders in the gastrointestinal (GI) tract. The best studied and most common of ...

  19. IBS and Non-GI Functional Disorders

    Science.gov (United States)

    ... disorders, particularly IBS and FMS. Estimates of the prevalence of IBS in FMS patients range from 30% ... Migraine and tension headaches Temperomandibular joint disorder (TMJ) Post-traumatic stress disorder (PTSD) Chronic pelvic pain (CPP) Interstitial cystitis and ...

  20. [BMW diagnostic criteria for IBS].

    Science.gov (United States)

    Matsueda, Kei

    2006-08-01

    Rome I diagnostic criteria for IBS was published in 1992 and it became a global diagnostic criteria. However, the criteria was not practical and somewhat complicated. Moreover, its symptomatic duration was too long (defined as more than 3 months) to be introduced in clinical practice. Therefore, Japanese member of BMW(Bowel Motility Workshop) tried to develop a new diagnostic criteria for IBS and it was established in 1995 by way of the Delphi method. The criteria was named as BMW diagnostic criteria and it was shown below: BMW diagnostic criteria for IBS (1995) At least one month or more of repetitive symptoms of the following 1) and 2) and no evidence of organic disease that likely to explain the symptoms. 1) Existence of abdominal pain, abdominal discomfort or abdominal distension 2) Existence of abnormal bowel movement (diarrhea, constipation) Abnormal bowel movement includes at least one of the below; (1) Abnormal stool frequency (2) Abnormal stool form (lumpy/hard or loose/wartery stool) Moreover, the following test should be performed as a rule to exclude organic diseases. (1) Urinalysis, fecal occult blood testing, CBC, chemistry (2) Barium enema or colonofiberscopic examination The other diagnostic criteria for IBS was also reviewed and their characteristics were compared with BMW diagnostic criteria.

  1. Multi-Wavelength Observations of Supernova 2011ei: Time-Dependent Classification of Type IIb and Ib Supernovae and Implications for their Progenitors

    CERN Document Server

    Milisavljevic, D; Soderberg, A M; Pignata, G; Chomiuk, L; Fesen, R; Bufano, F; Sanders, N E; Parrent, J T; Parker, S; Pickering, T; Buckley, D; Crawford, S; Gulbis, A A M; Hettlage, C; Hooper, E; Nordsieck, K; O'Donoghue, D; Husser, T -O; Potter, S; Kniazev, A; Kotze, P; Romero-Colmenero, E; Vaisanen, P; Wolf, M; Bartel, N; Bietenholz, M; Fransson, C; Mazzali, P; Brunthaler, A; Chakraborti, S; Levesque, E M; MacFadyen, A; Drescher, C; Bock, G; Marples, P; Anderson, J P; Benetti, S; Reichart, D; Ivarsen, K

    2012-01-01

    We present X-ray, UV/optical, and radio observations of the stripped-envelope, core-collapse supernova (SN) 2011ei, one of the least luminous SNe IIb or Ib observed to date. Our observations begin with a discovery within ~ 1 day of explosion and span several months afterward. Early optical spectra exhibit broad, Type II-like hydrogen Balmer profiles that subside rapidly and are replaced by Type Ib-like He-rich features on the timescale of one week. High-cadence monitoring of this transition identifies an absorption feature around 6250 Angstrom to be chiefly due to hydrogen, as opposed to C II, Ne I, or Si II. Similarities between this observed feature and several SNe Ib suggest that hydrogen absorption attributable to a high velocity (>12,000 km/s) H-rich shell is not rare in Type Ib events. Radio observations imply a shock velocity of v ~ 0.13c and a progenitor star mass-loss rate of ~ 1.4 x 10^{-5} Msolar yr^{-1} (assuming wind velocity v_w=1000 km/s). This is consistent with independent constraints estimat...

  2. Approximated and User Steerable tSNE for Progressive Visual Analytics.

    Science.gov (United States)

    Pezzotti, Nicola; Lelieveldt, Boudewijn; van der Maaten, Laurens; Hollt, Thomas; Eisemann, Elmar; Vilanova, Anna

    2016-05-19

    Progressive Visual Analytics aims at improving the interactivity in existing analytics techniques by means of visualization as well as interaction with intermediate results. One key method for data analysis is dimensionality reduction, for example, to produce 2D embeddings that can be visualized and analyzed efficiently. t-Distributed Stochastic Neighbor Embedding (tSNE) is a well-suited technique for the visualization of high-dimensional data. tSNE can create meaningful intermediate results but suffers from a slow initialization that constrains its application in Progressive Visual Analytics. We introduce a controllable tSNE approximation (A-tSNE), which trades off speed and accuracy, to enable interactive data exploration. We offer real-time visualization techniques, including a density-based solution and a Magic Lens to inspect the degree of approximation. With this feedback, the user can decide on local refinements and steer the approximation level during the analysis. We demonstrate our technique with several datasets, in a real-world research scenario and for the real-time analysis of high-dimensional streams to illustrate its effectiveness for interactive data analysis.

  3. Constraining dust and color variations of high-z SNe using NICMOS on Hubble Space Telescope

    CERN Document Server

    Nobili, S; Aldering, G; Amanullah, R; Barbary, K; Burns, M S; Dawson, K S; Deustua, S E; Faccioli, L; Fruchter, A S; Goldhaber, G; Goobar, A; Hook, I; Howell, D A; Kim, A G; Knop, R A; Lidman, C; Meyers, J; Nugent, P E; Pain, R; Panagia, N; Perlmutter, S; Rubin, D; Spadafora, A L; Strovink, M; Suzuki, N; Swift, H

    2009-01-01

    We present data from the Supernova Cosmology Project for five high redshift Type Ia supernovae (SNe Ia) that were obtained using the NICMOS infrared camera on the Hubble Space Telescope. We add two SNe from this sample to a rest-frame I-band Hubble diagram, doubling the number of high redshift supernovae on this diagram. This I-band Hubble diagram is consistent with a flat universe (Omega_Matter, Omega_Lambda= 0.29, 0.71). A homogeneous distribution of large grain dust in the intergalactic medium (replenishing dust) is incompatible with the data and is excluded at the 5 sigma confidence level, if the SN host galaxy reddening is corrected assuming R_V=1.75. We use both optical and infrared observations to compare photometric properties of distant SNe Ia with those of nearby objects. We find generally good agreement with the expected color evolution for all SNe except the highest redshift SN in our sample (SN 1997ek at z=0.863) which shows a peculiar color behavior. We also present spectra obtained from ground ...

  4. Malawi's Special Needs Education (SNE): Perspectives and Comparisons of Practice and Progress

    Science.gov (United States)

    Itimu, Ambumulire Nellie; Kopetz, Patricia B.

    2008-01-01

    The sub-Saharan country of Malawi is steeped in a robust educational reform movement to ensure "Education for All". Based upon country immersion experience and a review of the literature, this report highlights Malawi's nationwide support for its special needs education (SNE) campaign. First discussed is a brief overview of Malawi, its…

  5. Malawi's Special Needs Education (SNE): Perspectives and Comparisons of Practice and Progress

    Science.gov (United States)

    Itimu, Ambumulire Nellie; Kopetz, Patricia B.

    2008-01-01

    The sub-Saharan country of Malawi is steeped in a robust educational reform movement to ensure "Education for All". Based upon country immersion experience and a review of the literature, this report highlights Malawi's nationwide support for its special needs education (SNE) campaign. First discussed is a brief overview of Malawi, its people and…

  6. Type Ia SNe along redshift: the R(Si II) ratio and the expansion velocities in intermediate z supernovae

    CERN Document Server

    Altavilla, G; Balastegui, A; Méndez, J; Irwin, M; Espana-Bonet, C; Schamaneche, K; Balland, C; Ellis, Richard S; Fabbro, S; Folatelli, G; Goobar, A; Hillebrandt, W; McMahon, R M; Mouchet, M; Mourao, A; Nobili, S; Pain, R; Stanishev, V; Walton, N A

    2006-01-01

    We study intermediate--z SNe Ia using the empirical physical diagrams which enable to learn about those SNe explosions. This information can be very useful to reduce systematic uncertainties of the Hubble diagram of SNe Ia up to high z. The study of the expansion velocities and the measurement of the ratio $\\mathcal{R}$(\\SiII) allow to subtype those SNe Ia as done for nearby samples. The evolution of this ratio as seen in the diagram $\\mathcal{R}$(\\SiII)--(t) together with $\\mathcal{R}$(\\SiII)$_{max}$ versus (B-V)$_{0}$ indicate consistency of the properties at intermediate z compared with local SNe. At intermediate--z, the expansion velocities of Ca II and Si II are similar to the nearby counterparts. This is found in a sample of 6 SNe Ia in the range 0.033$\\leq z \\leq$0.329 discovered within the {\\it International Time Programme} (ITP) of {\\it Cosmology and Physics with SNe Ia} during the spring of 2002. Those supernovae were identified using the 4.2m William Herschel Telescope. Two SNe Ia at intermediate z...

  7. Stage IB endometrial cancer. Does lymphadenectomy replace adjuvant radiotherapy?

    Science.gov (United States)

    Bottke, Dirk; Wiegel, Thomas; Kreienberg, Rolf; Kurzeder, Christian; Sauer, Georg

    2007-11-01

    The role of surgical lymph node dissection and adjuvant radiation therapy (RT) in early stage endometrial cancer is no longer clearly defined. The increased appreciation of lymphadenectomy and the absence of survival advantage from adjuvant RT rise controversies how patients should adequately be treated in stage IB endometrial cancer. The aim of this review is to rule out the validity of either treatment option and determine which preference provides the best therapeutic benefit. Reports of relevant studies obtained from a search of PubMed and studies referenced in those reports were reviewed. Based on the available data in the literature, for stage IB grade 1 or 2, the risk of pelvic relapse is considered too low to justify pelvic RT. However, intravaginal RT (IVRT) should be recommended for those >or= 60 years old or with lymphovascular invasion (LVI). For patients with stage IB grade 3 (and IC all grades), the treatment recommendation is mainly based on whether surgical lymph node staging was performed. These patients have--without surgical lymph node staging--a high risk of pelvic recurrence and should therefore primarily undergo relaparotomy for lymphadenectomy or pelvic RT as second choice. If these patients had a surgical lymph node staging, then IVRT alone is a reasonable alternative to pelvic RT. Overall survival may not be the only ideal endpoint for stage IB endometrial cancer since causes of death are mostly other than endometrial cancer. Conventional pelvic RT may be overtreatment in some patients, in particular in those patients with a large number of negative lymph nodes after lymphadenectomy. However, negative surgical staging should not be understood as adjuvant RT can be omitted in all patients.

  8. Brain-gut interactions in IBS

    Directory of Open Access Journals (Sweden)

    Jakub eFichna

    2012-07-01

    Full Text Available Irritable bowel syndrome (IBS is a common gastrointestinal (GI disorder with an estimated prevalence of 10-20%. Current understanding of the pathophysiology of IBS is incomplete due to the lack of a clearly identified pathological abnormality and due to the lack of reliable biomarkers. Possible mechanisms believed to contribute to IBS development and IBS like symptoms include physical stressors, such as infection or inflammation, psychological and environmental factors, like anxiety, depression and significant negative life events. Some of these mechanisms may involve the brain-gut axis (BGA. In this article we review the current knowledge on the possible involvement of the BGA in IBS and discuss new directions for potential future therapies of IBS.

  9. Multi-layered Spectral Formation in SNe Ia Around Maximum Light

    Energy Technology Data Exchange (ETDEWEB)

    Bongard, Sebastien; Baron, E.; Smadja, G.; Branch, David; Hauschildt, Peter H.

    2008-09-02

    We use the radiative transfer code \\phx\\ to study the line formation of the wavelength region 5000-7000 Angstrom. This is the region where the SNe Ia defining Si II feature occurs. This region is important since the ratio of the two nearby silicon lines has been shown to correlate with the absolute blue magnitude. We use a grid of LTE synthetic spectral models to investigate the formation of line features in the spectra of SNe Ia. By isolating the main contributors to the spectral formation we show that the ions that drive the spectral ratio are FeIII, FeII, SiII and SII. While the first two strongly dominate the flux transfer, the latter two form in the same physical region inside of the supernova. We also show that the naive blackbody that one would derive from a fit to the observed spectrum is far different than the true underlying continuum.

  10. Status on bidimensional dark energy parameterizations using SNe Ia JLA and BAO datasets

    CERN Document Server

    Escamilla-Rivera, Celia

    2016-01-01

    Using current observations forecast type Ia supernovae (SNe Ia) Joint Lightcurve Analysis (JLA) binned and baryon acoustic oscillations (BAO), in this paper we investigate six bidimensional dark energy parameterizations in order to explore which has more constraining power. Our results indicate that for Taylor series-like parameterizations at second order in redshift $z$, the tension ($\\sigma$-distance) between these data sets seems to be reduced and their behaviour are $<$1$\\sigma$ compatible with $\\Lambda$CDM.

  11. Optical photometry and spectroscopy of the low-luminosity, broad-lined Ic supernova iPTF15dld

    Science.gov (United States)

    Pian, E.; Tomasella, L.; Cappellaro, E.; Benetti, S.; Mazzali, P. A.; Baltay, C.; Branchesi, M.; Brocato, E.; Campana, S.; Copperwheat, C.; Covino, S.; D'Avanzo, P.; Ellman, N.; Grado, A.; Melandri, A.; Palazzi, E.; Piascik, A.; Piranomonte, S.; Rabinowitz, D.; Raimondo, G.; Smartt, S. J.; Steele, I. A.; Stritzinger, M.; Yang, S.; Ascenzi, S.; Della Valle, M.; Gal-Yam, A.; Getman, F.; Greco, G.; Inserra, C.; Kankare, E.; Limatola, L.; Nicastro, L.; Pastorello, A.; Pulone, L.; Stamerra, A.; Stella, L.; Stratta, G.; Tartaglia, L.; Turatto, M.

    2017-04-01

    Core-collapse stripped-envelope supernova (SN) explosions reflect the diversity of physical parameters and evolutionary paths of their massive star progenitors. We have observed the Type Ic SN iPTF15dld (z = 0.047), reported by the Palomar Transient Factory. Spectra were taken starting 20 rest-frame days after maximum luminosity and are affected by a young stellar population background. Broad spectral absorption lines associated with the SN are detected over the continuum, similar to those measured for broad-lined, highly energetic SNe Ic. The light curve and maximum luminosity are instead more similar to those of low luminosity, narrow-lined Ic SNe. This suggests a behaviour whereby certain highly stripped-envelope SNe do not produce a large amount of 56Ni, but the explosion is sufficiently energetic that a large fraction of the ejecta is accelerated to higher than usual velocities. We estimate SN iPTF15dld had a main-sequence progenitor of 20-25 M⊙, produced a 56Ni mass of ∼0.1-0.2 M⊙, had an ejecta mass of [2-10] M⊙, and a kinetic energy of [1-18] × 1051 erg.

  12. Late-time Light Curves of Type II Supernovae: Physical Properties of SNe and Their Environment

    CERN Document Server

    Otsuka, Masaaki; Panagia, Nino; Fabbri, Joanna; Barlow, Michael J; Clayton, Geoffrey C; Gallagher, Joseph S; Sugerman, Ben E K; Wesson, Roger; Andrews, Jennifer E; Ercolano, Barbara; Welch, Douglas

    2011-01-01

    We present BVRIJHK band photometry of 6 core-collapse supernovae, SNe 1999bw, 2002hh, 2003gd, 2004et, 2005cs, and 2006bc measured at late epochs (>2 yrs) based on Hubble Space Telescope (HST), Gemini north, and WIYN telescopes. We also show the JHK lightcurves of a supernova impostor SN 2008S up to day 575. Of our 43 HST observations in total, 36 observations are successful in detecting the light from the SNe alone and measuring magnitudes of all the targets. HST observations show a resolved scattered light echo around SN 2003gd at day 1520 and around SN 2002hh at day 1717. Our Gemini and WIYN observations detected SNe 2002hh and 2004et, as well. Combining our data with previously published data, we show VRIJHK-band lightcurves and estimate decline magnitude rates at each band in 4 different phases. Our prior work on these lightcurves and other data indicate that dust is forming in our targets from day ~300-400, supporting SN dust formation theory. In this paper we focus on other physical properties derived f...

  13. ON THE DEPENDENCE OF TYPE Ia SNe LUMINOSITIES ON THE METALLICITY OF THEIR HOST GALAXIES

    Energy Technology Data Exchange (ETDEWEB)

    Moreno-Raya, Manuel E.; Mollá, Mercedes [Dpto.de Investigación Básica, C.I.E.M.A.T., Avda. Complutense 40, E-28040 Madrid (Spain); López-Sánchez, Ángel R. [Australian Astronomical Observatory, P.O. Box 915, North Ryde, NSW 1670 (Australia); Galbany, Lluís [Millennium Institute of Astrophysics MAS, Nuncio Monseñor Sótero Sanz 100, Providencia, 7500011 Santiago (Chile); Vílchez, José Manuel [Instituto de Astrofísica de Andalucía (CSIC), Apdo. 3004, E-18080 Granada (Spain); Rosell, Aurelio Carnero [Observatório Nacional, and LIneA Laboratório Interinstitucional de e-Astronomia, Rua Gal. José Cristino 77 Rio de Janeiro, RJ 20921-400 (Brazil); Domínguez, Inmaculada, E-mail: manuelemilio.moreno@ciemat.es [Departamento de Física Teórica y del Cosmos, Universidad de Granada, E-18071 Granada (Spain)

    2016-02-10

    The metallicity of the progenitor system producing a type Ia supernova (SN Ia) could play a role in its maximum luminosity, as suggested by theoretical predictions. We present an observational study to investigate if such a relationship exists. Using the 4.2 m William Herschel Telescope (WHT) we have obtained intermediate-resolution spectroscopy data of a sample of 28 local galaxies hosting SNe Ia, for which distances have been derived using methods independent of those based on SN Ia parameters. From the emission lines observed in their optical spectra, we derived the gas-phase oxygen abundance in the region where each SN Ia exploded. Our data show a trend, with an 80% of chance not being due to random fluctuation, between SNe Ia absolute magnitudes and the oxygen abundances of the host galaxies, in the sense that luminosities tend to be higher for galaxies with lower metallicities. This result seems likely to be in agreement with both the theoretically expected behavior and with other observational results. This dependence M{sub B}–Z might induce systematic errors when it is not considered when deriving SNe Ia luminosities and then using them to derive cosmological distances.

  14. Constraining a bulk viscous matter-dominated cosmological model using SNe Ia, CMB and LSS

    CERN Document Server

    Avelino, Arturo; Guzmán, F S

    2008-01-01

    We present and constrain a cosmological model which component is a pressureless fluid with bulk viscosity as an explanation for the present accelerated expansion of the universe. We study the particular model of a constant bulk viscosity coefficient \\zeta_m. The possible values of \\zeta_m are constrained using the cosmological tests of SNe Ia Gold 2006 sample, the CMB shift parameter R from the three-year WMAP observations, the Baryon Acoustic Oscillation (BAO) peak A from the Sloan Digital Sky Survey (SDSS) and the Second Law of Thermodynamics (SLT). It was found that this model is in agreement with the SLT using only the SNe Ia test. However when the model is submitted to the three cosmological tests together (SNe+CMB+BAO) the results are: 1.- the model violates the SLT, 2.- predicts a value of H_0 \\approx 53 km sec^{-1} Mpc^{-1} for the Hubble constant, and 3.- we obtain a bad fit to data with a \\chi^2_{min} \\approx 400 (\\chi^2_{d.o.f.} \\approx 2.2). These results indicate that this model is ruled out by t...

  15. Non-absorbed Antibiotics for IBS

    Science.gov (United States)

    2012-03-16

    physiologic, rather than clinical, endpoints. Over the last decade, the Food and Drug Administration has favored a global IBS endpoint for Phase 3...question surrounding the use of antibiotics such as rifaximin, as well as agents such as probiotics , as IBS therapies is exactly how they are exert- ing

  16. Simplified design of IC amplifiers

    CERN Document Server

    Lenk, John

    1996-01-01

    Simplified Design of IC Amplifiers has something for everyone involved in electronics. No matter what skill level, this book shows how to design and experiment with IC amplifiers. For experimenters, students, and serious hobbyists, this book provides sufficient information to design and build IC amplifier circuits from 'scratch'. For working engineers who design amplifier circuits or select IC amplifiers, the book provides a variety of circuit configurations to make designing easier.Provides basics for all phases of practical design.Covers the most popular forms for amplif

  17. Constraints on the Binary Companion to the SN Ic 1994I Progenitor

    CERN Document Server

    Van Dyk, Schuyler D; Zapartas, Emmanouil

    2016-01-01

    Core-collapse supernovae (SNe), marking the deaths of massive stars, are among the most powerful explosions in the Universe, responsible, e.g., for a predominant synthesis of chemical elements in their host galaxies. The majority of massive stars are thought to be born in close binary systems. To date, putative binary companions to the progenitors of SNe may have been detected in only two cases, SNe 1993J and 2011dh. We report on the search for a companion of the progenitor of the Type Ic SN 1994I, long considered to have been the result of binary interaction. Twenty years after explosion, we used the Hubble Space Telescope to observe the SN site in the ultraviolet (F275W and F336W bands), resulting in deep upper limits on the expected companion: F275W > 26.1 mag and F336W > 24.7 mag. These allows us to exclude the presence of a main sequence companion with a mass >~ 10 Msun. Through comparison with theoretical simulations of possible progenitor populations, we show that the upper limits to a companion detect...

  18. The ICS International Chronostratigraphic Chart

    NARCIS (Netherlands)

    Cohen, K.M.; Finney, S.C.; Gibbard, P.L.; Fan, J.-X.

    2013-01-01

    The International Commission on Stratigraphy (ICS) has a long tradition of producing international charts that communicate higher-order divisions of geological time and actual knowledge on the absolute numerical ages of their boundaries. The primary objective of ICS is to define precisely a global

  19. Search for VHE Gamma-Ray Emission from Young SNe with H.E.S.S

    CERN Document Server

    Lennarz, D

    2013-01-01

    Supernova (SN) remnants are a well motivated candidate for the acceleration sites of cosmic rays with energies up to the knee (10^15 eV). It has been suggested that also young SNe (~10 GeV) gamma-ray radiation. The H.E.S.S. imaging air Cherenkov telescope array is an instrument sensitive to such radiation. In this contribution, the pointing directions of the H.E.S.S. telescopes are compared to a recently published, extragalactic SN catalogue to identify coincidental observations. The results of the data analysis are discussed.

  20. Does a low FODMAP diet help IBS?

    Science.gov (United States)

    2015-08-01

    Irritable bowel syndrome (IBS) is a common condition that can have a significant impact on a person's quality of life. The cause of IBS is unknown but several mechanisms have been proposed including visceral hypersensitivity, central sensitisation, abnormal gut motility and altered gut microbiota. IBS is challenging to manage and many patients report insufficient symptomatic relief from treatment. Approximately 60% of patients identify food as a trigger for their symptoms, and there has been interest in exclusion diets for managing IBS. Dietary adaptation is a common self-management strategy for patients with IBS, with many self-diagnosing intolerance to specific foods. This may lead to patients adopting over-restrictive or inappropriate diets. In recent years, a diet low in poorly absorbed short-chain carbohydrates, known collectively as FODMAPs (fermentable oligosaccharides, disaccharides, monosaccharides and polyols), has been advocated for the treatment of IBS. Here, we discuss the background to the FODMAP diet and review the evidence supporting its use for people with IBS.

  1. SN 2009ib: A Type II-P Supernova with an Unusually Long Plateau

    CERN Document Server

    Takats, K; Pumo, M L; Paillas, E; Zampieri, L; Elias-Rosa, N; Benetti, S; Bufano, F; Cappellaro, E; Ergon, M; Fraser, M; Hamuy, M; Inserra, C; Kankare, E; Smartt, S J; Stritzinger, M D; Van Dyk, S D; Haislip, J B; LaCluyze, A P; Moore, J P; Reichart, D

    2015-01-01

    We present optical and near-infrared photometry and spectroscopy of SN 2009ib, a Type II-P supernova in NGC 1559. This object has moderate brightness, similar to those of the intermediate-luminosity SNe 2008in and 2009N. Its plateau phase is unusually long, lasting for about 130 days after explosion. The spectra are similar to those of the subluminous SN 2002gd, with moderate expansion velocities. We estimate the $^{56}$Ni mass produced as $0.046 \\pm 0.015\\,{\\rm M}_{\\sun}$. We determine the distance to SN 2009ib using both the expanding photosphere method (EPM) and the standard candle method. We also apply EPM to SN 1986L, a type II-P SN that exploded in the same galaxy. Combining the results of different methods, we conclude the distance to NGC 1559 as $D=19.8 \\pm 2.8$ Mpc. We examine archival, pre-explosion images of the field taken with the Hubble Space Telescope, and find a faint source at the position of the SN, which has a yellow colour ($(V-I)_0 = 0.85$ mag). Assuming it is a single star, we estimate i...

  2. VizieR Online Data Catalog: SNe IIn observations and properties (Ofek+, 2014)

    Science.gov (United States)

    Ofek, E. O.; Sullivan, M.; Shaviv, N. J.; Steinbok, A.; Arcavi, I.; Gal-Yam, A.; Tal, D.; Kulkarni, S. R.; Nugent, P. E.; Ben-Ami, S.; Kasliwal, M. M.; Cenko, S. B.; Laher, R.; Surace, J.; Bloom, J. S.; Filippenko, A. V.; Silverman, J. M.; Yaron, O.

    2017-03-01

    We used PTF observations of the SNe in our sample. The PTF data reduction is described by Laher et al. (2014PASP..126..674L), and the photometric calibration is discussed by Ofek et al. (2012PASP..124...62O, 2012PASP..124..854O). Our search is based on image subtraction, and the flux residuals in the individual image subtractions for all the SNe in our sample are listed in Table 2. In order to calculate the rate of SN precursors, we need to estimate the "control time"-that is, for how long each SN location was observed (prior to its explosion) to a given limiting magnitude. Table 5 lists, for each SN, the time bin windows (of 15 days) prior to the SN explosion and the 5σ sensitivity depth at each window for bins with more than five measurements (second channel), or the median 6σ limiting magnitudes at windows with fewer than six measurements (first channel). (4 data files).

  3. Constraints on the Progenitors of SNeIa & Implications for the Cosmological Equation of State

    CERN Document Server

    Dominguez, I; Straniero, O

    2001-01-01

    Detailed calculations for the stellar evolution, explosion and light curves have been performed to quantify the influence of the main sequence mass M(MS) and the metallicity of the progenitor on the structure of the exploding WD which are thought to be the progenitors of SNe Ia. In particular,we study the effects of progenitors on the brightness decline relation M(dM_15) which is a corner stone for the use of SNe Ia as cosmological yard-stick.M(MS) has been identified as the decisive factor to change the energetics of the explosion and dominates the variations in the rise-time to decline relation of light curves. M(MS) has little effect on the color index B-V. For similar decline rates dM_15, the flux at maximum brightness relative to the flux on the radioactive tail decreases systematically with M(MS) by about 0.2mag. This change goes along with a reduc- tion of the photospheric expansion velocity $v_{ph}$ by about 2000 km/sec. A change in the central density has the opposite dependency. The metallicity Z af...

  4. VizieR Online Data Catalog: Palomar Transient Factory SNe IIn photometry (Ofek+, 2014)

    Science.gov (United States)

    Ofek, E. O.; Arcavi, I.; Tal, D.; Sullivan, M.; Gal-Yam, A.; Kulkarni, S. R.; Nugent, P. E.; Ben-Ami, S.; Bersier, D.; Cao, Y.; Cenko, S. B.; De Cia, A.; Filippenko, A. V.; Fransson, C.; Kasliwal, M. M.; Laher, R.; Surace, J.; Quimby, R.; Yaron, O.

    2017-07-01

    The Palomar Transient Factory (PTF; Law et al. 2009PASP..121.1395L; Rau et al. 2009PASP..121.1334R) and its extension the intermediate PTF (iPTF) found over 2200 spectroscopically confirmed SNe. We selected 19 SNe IIn for which PTF/iPTF has good coverage of the light-curve rise and peak; they are listed in Table 1. Optical spectra were obtained with a variety of telescopes and instruments, including the Double Spectrograph (Oke & Gunn 1982PASP...94..586O) at the Palomar 5 m Hale telescope, the Kast spectrograph (Miller & Stone 1993, Lick Observatory Technical Report 66 (Santa Cruz, CA: Lick Observatory)) at the Lick 3 m Shane telescope, the Low Resolution Imaging Spectrometer (Oke et al. 1995PASP..107..375O) on the Keck-1 10 m telescope, and the Deep Extragalactic Imaging Multi-Object Spectrograph (Faber et al. 2003SPIE.4841.1657F) on the Keck-2 10 m telescope. (2 data files).

  5. Development of solid lipid nanoparticles (SLNs) of lopinavir using hot self nano-emulsification (SNE) technique.

    Science.gov (United States)

    Negi, Jeetendra Singh; Chattopadhyay, Pronobesh; Sharma, Ashok Kumar; Ram, Veerma

    2013-01-23

    Solid lipid nanoparticles (SLNs) of poor orally bioavailable drug lopinavir were prepared using hot self nano-emulsification (SNE) technique. Hot isotropic mixture of stearic acid, poloxamer and polyethylene glycol was spontaneously self nano-emulsify in hot water and SLNs were formed with subsequent rapid cooling. Self nano-emulsification ability of stearic acid, poloxamer and polyethylene glycol mixture was assessed by ternary phase diagram study. Optimized SLNs were having particle size of 180.6 ± 2.32 nm (PDI=0.133 ± 0.001), 91.5 ± 1.3% entrapment efficiency and zeta potential of -13.4 ± 0.56 mV. SLNs were evaluated by transmission electron microscopy (TEM) and atomic force microscopy (AFM) for morphological study. Further, Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) of SLNs were also performed for checking solid state characterization. Higher oral bioavailability was found for lopinavir loaded SLNs in comparison to bulk lopinavir due to higher lymphatic drug transport (p<0.05). Results indicate that SLNs of higher fatty acids can be successfully prepared by hot SNE technique.

  6. Observational constraints from SNe Ia and Gamma-Ray Bursts on a clumpy universe

    CERN Document Server

    Bretón, Nora

    2013-01-01

    The luminosity distance describing the effect of local inhomogeneities in the propagation of light proposed by Zeldovich-Kantowski-Dyer-Roeder (ZKDR) is tested with two probes for two distinct ranges of redshifts: supernovae Ia (SNe Ia) in 0.015 < z < 1.414 and gamma-ray bursts (GRBs) in 1.547 < z < 3.57. Our analysis is performed by a Markov Chain Monte Carlo (MCMC) code that allows us to constrain the matter density parameter \\Omega_m as well as the smoothness parameter $\\alpha$ that measures the inhomogeneous-homogeneous rate of the cosmic fluid in a flat \\LambdaCDM model. The obtained best fits are (\\Omega_m=0.285^{+0.019}_{-0.018}, \\alpha= 0.856^{+0.106}_{-0.176}) from SNe Ia and (\\Omega_m=0.259^{+0.028}_{-0.028}, \\alpha=0.587^{+0.201}_{-0.202}) from GRBs, while from the joint analysis the best fits are (\\Omega_m=0.284^{+0.021}_{-0.020}, \\alpha= 0.685^{+0.164}_{-0.171}) with a \\chi^2_{\\rm red}=0.975. The value of the smoothness parameter $\\alpha$ indicates a clumped universe however it does n...

  7. On the dependence of the type Ia SNe luminosities on the metallicity of their host galaxies

    CERN Document Server

    Moreno-Raya, Manuel E; López-Sánchez, Ángel R; Galbany, Lluís; Vílchez, José; Carnero, Aurelio; Domínguez, Inma

    2015-01-01

    The metallicity of the progenitor system producing a type Ia supernova (SN Ia) could play a role in its maximum luminosity, as suggested by theoretical predictions. We present an observational study to investigate if such a relationship there exists. Using the 4.2m WHT we have obtained intermediate-resolution spectroscopy data of a sample of 28 local galaxies hosting SNe Ia, for which distances have been derived using methods independent to those based on the own SN Ia parameters. From the emission lines observed in their optical spectrum, we derived the gas-phase oxygen abundance in the region where each SN Ia exploded. Our data show a trend, with a 80% of chance not to be due to random fluctuation, between SNe Ia absolute magnitudes and the oxygen abundances of the host galaxies, in the sense that luminosities tend to be higher for galaxies with lower metallicities. This result seems like to be in agreement with both the theoretically expected behavior, and with other observational results. This dependence ...

  8. TWO SNe Ia AT REDSHIFT ∼2: IMPROVED CLASSIFICATION AND REDSHIFT DETERMINATION WITH MEDIUM-BAND INFRARED IMAGING

    Energy Technology Data Exchange (ETDEWEB)

    Rodney, Steven A.; Riess, Adam G.; Jones, David O. [Department of Physics and Astronomy, The Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218 (United States); Scolnic, Daniel M. [Department of Physics, The University of Chicago, Chicago, IL 60637 (United States); Hemmati, Shoubaneh; Mobasher, Bahram [Department of Physics and Astronomy, University of California, Riverside, CA 92521 (United States); Molino, Alberto [Instituto de Astrofísica de Andalucía (CSIC), E-18080 Granada (Spain); McCully, Curtis [Las Cumbres Observatory Global Telescope Network, 6740 Cortona Dr., Suite 102, Goleta, CA 93117 (United States); Strolger, Louis-Gregory; Casertano, Stefano [Space Telescope Science Institute, 3700 San Martin Dr., Baltimore, MD 21218 (United States); Graur, Or [Center for Cosmology and Particle Physics, New York University, New York, NY 10003 (United States); Hayden, Brian, E-mail: srodney@sc.edu [Department of Physics, University of Notre Dame, Notre Dame, IN 46556 (United States)

    2015-11-15

    We present two supernovae (SNe) discovered with the Hubble Space Telescope (HST) in the Cosmic Assembly Near-infrared Deep Extragalactic Legacy Survey, an HST multi-cycle treasury program. We classify both objects as SNe Ia and find redshifts of z = 1.80 ± 0.02 and 2.26{sup +0.02}{sub −0.10}, the latter of which is the highest redshift SN Ia yet seen. Using light curve fitting we determine luminosity distances and find that both objects are consistent with a standard ΛCDM cosmological model. These SNe were observed using the HST Wide Field Camera 3 infrared detector, with imaging in both wide- and medium-band filters. We demonstrate that the classification and redshift estimates are significantly improved by the inclusion of single-epoch medium-band observations. This medium-band imaging approximates a very low resolution spectrum (λ/Δλ ≲ 100) which can isolate broad spectral absorption features that differentiate SNe Ia from their most common core collapse cousins. This medium-band method is also insensitive to dust extinction and (unlike grism spectroscopy) it is not affected by contamination from the SN host galaxy or other nearby sources. As such, it can provide a more efficient—though less precise—alternative to IR spectroscopy for high-z SNe.

  9. The evolution of the 3D shape of the broad-lined Type Ic SN 2014ad

    Science.gov (United States)

    Stevance, H. F.; Maund, J. R.; Baade, D.; Höflich, P.; Howerton, S.; Patat, F.; Rose, M.; Spyromilio, J.; Wheeler, J. C.; Wang, L.

    2017-08-01

    We present optical spectropolarimetry and spectroscopy of the broad-lined Type Ic (Ic-bl) SN 2014ad. Our spectropolarimetric observations cover seven epochs, from -2 to 66 d after V-band maximum, and the spectroscopic data were acquired from -2 to +107 d. The photospheric velocity estimates showed ejecta speeds similar to those of SN 1998bw and other SNe associated with gamma-ray bursts (GRBs). The spectropolarimetric data revealed aspherical outer ejecta and a nearly spherical interior. The polarization associated with O I λ7774 and the Ca II infrared triplet suggests a clumpy and highly asymmetrical distribution of these two species within the ejecta. Furthermore, it was shown that the two line forming regions must have been spatially distinct and oxygen was found to have higher velocities than calcium. Another oxygen line-forming region was also identified much closer to the core of the explosion and distributed in a spherical shell. It is difficult to reconcile the geometry of the deeper ejecta with a jet driven explosion, but the high ejecta velocities of SN 2014ad are typical of those observed in SNe Ic-bl with GRBs and the behaviour of the oxygen and calcium line-forming regions is consistent with fully jet-driven models. The metallicity of the host galaxy of SN 2014ad was also calculated and compared to that of the hosts of other SNe Ic-bl with and without GRBs, but due to the overlap in the two populations no conclusion could be drawn.

  10. An extremely prolific supernova factory in the buried nucleus of the starburst galaxy IC 694

    Science.gov (United States)

    Pérez-Torres, M. A.; Romero-Cañizales, C.; Alberdi, A.; Polatidis, A.

    2009-11-01

    Context: The central kiloparsec of many local uminous infrared galaxies are known to host intense bursts of massive star formation, leading to numerous explosions of core-collapse supernovae (CCSNe). However, the dust-enshrouded regions where those supernovae explode hamper their detection at optical and near-infrared wavelengths. Aims: We investigate the nuclear region of the starburst galaxy IC 694 (=Arp 299-A) at radio wavelengths, aimed at discovering recently exploded CCSNe, as well as determining their rate of explosion, which carries crucial information about star formation rates, the initial mass function, and the starburst processes in action. Methods: We use the electronic European VLBI Network to image with milliarcsecond resolution the 5.0 GHz compact radio emission of the innermost nuclear region of IC 694. Results: Our observations detect a rich cluster of 26 compact radio emitting sources in the central 150 pc of the nuclear starburst in IC 694. The high brightness temperatures observed for the compact sources are indicative of a non-thermal origin for the observed radio emission, implying that most, if not all, of those sources are young radio supernovae (RSNe) and supernova remnants (SNRs). We find evidence of at least three relatively young, slowly evolving, long-lasting RSNe (A0, A12, and A15) that appear to have unusual properties, suggesting that the conditions in the local circumstellar medium (CSM) play a significant role in determining the radio behaviour of expanding SNe. Their radio luminosities are typical of normal RSNe, which result from the explosion of type IIP/b and type IIL SNe. All of these results provide support for a recent (less than 10-15 Myr) instantaneous starburst in the innermost regions of IC 694. Tables 1, 2 and Appendix are only available in electronic form at http://www.aanda.org

  11. Photometric Identification of Young Stripped-Core Supernovae

    OpenAIRE

    Gal-Yam, Avishay; Poznanski, Dovi; Maoz, Dan; Filippenko, Alexei V.; Foley, Ryan J.

    2004-01-01

    We present a method designed to identify the spectral type of young (less than ~30 days after explosion) and nearby (z < ~0.05) supernovae (SNe) using their broad-band colors. In particular, we show that stripped-core SNe (i.e., hydrogen deficient core-collapse events, spectroscopically defined as SNe Ib and SNe Ic, including broad-lined SN 1998bw-like events) can be clearly distinguished from other types of SNe. Using the full census of nearby SNe discovered during the year 2002, we estimate...

  12. Lessons learnt from post-infectious IBS

    Directory of Open Access Journals (Sweden)

    Sushil eSarna

    2011-08-01

    Full Text Available The development of IBS symptoms– altered bowel function and abdominal cramping in a subset of adult subjects exposed to severe enteric infections opened up an unprecedented opportunity to understand the etiology of this poorly understood disorder. Perhaps, for the reasons that these symptoms follow a severe enteric infection, and mucosal biopsy tissues are readily available, the focus of most studies thus far has been to show that mild/low-grade mucosal inflammation persisting after the initial infection has subsided causes the IBS symptoms. Parallel studies in non-infectious IBS patients, who did not have prior enteritis, showed similar mild mucosal inflammation. Together, these studies examined the mucosal infiltration of specific immune cells, increase of select inflammatory mediators, mast cell and enterochromafin cell hyperplasia and epithelial permeability. In spite of the fact that the data on these topics were not consistent among different studies and clinical trials with prednisone, fluoxetine and kitotifen failed to provide relief of IBS symptoms, the predominant conclusions were that mild mucosal inflammation is the cause of IBS symptoms. However, the circular smooth muscle cells, and myenteric neurons are the primary regulators of gut motility function, while primary afferent neurons and CNS play essential roles in induction of visceral hypersensitivity - no explanation was provided as to how mild mucosal inflammation causes dysfunction in cells far removed. Accumulating evidence shows that mild mucosal inflammation in IBS patients is in physiological range. It has little deleterious effects on cells within its own environment and therefore it is unlikely to affect cells in the muscularis externa. This review discusses the disconnect between the focus on mild/low-grade mucosal inflammation and the potential mechanisms and molecular dysfunctions in smooth muscle cells, myenteric neurons and primary afferent neurons that may

  13. SNe Ia Tests of Quintessence Tracker Cosmology in an Anisotropic Background

    CERN Document Server

    Miranda, W; Pigozzo, C

    2014-01-01

    We investigate the observational effects of a quintessence model in an anisotropic spacetime. The anisotropic metric is a non-rotating particular case of a generalized Godel's metric and is classified as Bianchi III. This metric is an exact solution of the Einstein-Klein-Gordon field equations with an anisotropic scalar field, which is responsible for the anisotropy of the spacetime geometry. We test the model against observations of type Ia supernovae, analyzing the SDSS dataset calibrated with the MLCS2k2 fitter, and the results are compared to standard quintessence models with Ratra-Peebles potentials. We obtain a good agreement with observations, with best values for the matter and curvature density parameters $\\Omega_M = 0.29$ and $\\Omega_k= 0.01$ respectively. We conclude that present SNe Ia observations cannot, alone, distinguish a possible anisotropic axis in the cosmos.

  14. Are Galaxy Clusters Suggesting an Accelerating Universe Independent of SNe Ia and Gravity Metric Theory?

    CERN Document Server

    Lima, J A S; Cunha, J V

    2009-01-01

    A kinematic method to access cosmic acceleration based exclusively on the Sunyaev-Zel'dovich effect (SZE) and X-ray surface brightness data from galaxy clusters is proposed. By using the SZE/X-ray data from 38 galaxy clusters [Bonament et al., Astrop. J. 647, 25 (2006)], we find that the present Universe is accelerating and that the transition from an earlier decelerating to a late time accelerating regime occurred relatively recent. Such results are fully independent on the validity of any metric gravity theory, the possible matter-energy contents filling the Universe, as well as on the SNe type Ia Hubble diagram from which the present acceleration was inferred. The ability of the ongoing Planck satellite mission to obtain tighter constraints on the expansion history through SZE/X-ray angular diameters is also discussed. Two simple simulations of future Planck data suggest that such technique will be competitive with supernova data besides being complementary to it.

  15. Reconstruction of the interaction term between dark matter and dark energy using SNe Ia

    CERN Document Server

    Solano, Freddy Cueva

    2011-01-01

    We apply a parametric reconstruction method to a homogeneous, isotropic and spatially flat Friedmann-Robertson-Walker (FRW) cosmological model filled of a fluid of dark energy (DE) with constant equation of state (EOS) parameter interacting with dark matter (DM). The reconstruction method is based on expansions of the general interaction term and the relevant cosmological variables in terms of Chebyshev polynomials which form a complete set orthonormal functions. This interaction term describes an exchange of energy flow between the DE and DM within dark sector. To show how the method works we do the reconstruction of the interaction function expanding it in terms of only the first six Chebyshev polynomials and obtain the best estimation for the coefficients of the expansion assuming two models: (a) a DE equation of the state parameter w =-1 (an interacting cosmological constant), (b) a DE equation of the state parameter w = constant, and using the Union2 SNe Ia data set from "The Supernova Cosmology Project"...

  16. SNe Ia tests of quintessence tracker cosmology in an anisotropic background

    Science.gov (United States)

    Miranda, W.; Carneiro, S.; Pigozzo, C.

    2014-07-01

    We investigate the observational effects of a quintessence model in an anisotropic spacetime. The anisotropic metric is a non-rotating particular case of a generalized Gödel's metric and is classified as Bianchi III. This metric is an exact solution of the Einstein-Klein-Gordon field equations with an anisotropic scalar field ψ, which is responsible for the anisotropy of the spacetime geometry. We test the model against observations of type Ia supernovae, analyzing the SDSS dataset calibrated with the MLCS2k2 fitter, and the results are compared to standard quintessence models with Ratra-Peebles potentials. We obtain a good agreement with observations, with best values for the matter and curvature density parameters ΩM = 0.29 and Ωk= 0.01 respectively. We conclude that present SNe Ia observations cannot, alone, distinguish a possible anisotropic axis in the cosmos.

  17. Continuum Foreground Polarization and Na I Absorption in Type Ia SNe

    Science.gov (United States)

    Zelaya, P.; Clocchiatti, A.; Baade, D.; Höflich, P.; Maund, J.; Patat, F.; Quinn, J. R.; Reilly, E.; Wang, L.; Wheeler, J. C.; Förster, F.; González-Gaitán, S.

    2017-02-01

    We present a study of the continuum polarization over the 400–600 nm range of 19 SNe Ia obtained with FORS at the VLT. We separate them into those that show Na i D lines at the velocity of their hosts and those that do not. Continuum polarization of the sodium sample near maximum light displays a broad range of values, from extremely polarized cases like SN 2006X to almost unpolarized ones like SN 2011ae. The non-sodium sample shows, typically, smaller polarization values. The continuum polarization of the sodium sample in the 400–600 nm range is linear with wavelength and can be characterized by the mean polarization ({P}{mean}). Its values span a wide range and show a linear correlation with color, color excess, and extinction in the visual band. Larger dispersion correlations were found with the equivalent width of the Na i D and Ca ii H and K lines, and also a noisy relation between {P}{mean} and R V , the ratio of total to selective extinction. Redder SNe show stronger continuum polarization, with larger color excesses and extinctions. We also confirm that high continuum polarization is associated with small values of R V . The correlation between extinction and polarization—and polarization angles—suggest that the dominant fraction of dust polarization is imprinted in interstellar regions of the host galaxies. We show that Na i D lines from foreground matter in the SN host are usually associated with non-galactic ISM, challenging the typical assumptions in foreground interstellar polarization models. Based on observations made with ESO Telescopes at the Paranal Observatory under programs 068.D-0571(A), 069.D-0438(A), 070.D-0111(A), 076.D-0178(A), 079.D-0090(A), 080.D-0108(A), 081.D-0558(A), 085.D-0731(A), and 086.D-0262(A). Also based on observations collected at the German-Spanish Astronomical Center, Calar Alto (Spain).

  18. [Phenolic compounds in leaves insertions of Mentha × villosa Huds. cv. Snežná].

    Science.gov (United States)

    Tekeľová, Daniela; Bittner Fialová, Silvia; Tóth, Jaroslav; Czigle, Szilvia

    Lamiaceae plants mostly accumulate active ingredients in their leaves. The subfamily Nepetoideae, including the genus Mentha L., is characterized by the presence of essential oil and antioxidant phenolics, chiefly hydroxycinnamic acids with predominance of rosmarinic acid, and flavonoids. Mentha × piperita and M. spicata are the most broadly used mints in both medicine and industry, while M. x villosa is less known in our country. Herbal drugs in the form of leaves are usually analysed unpartitioned, while single leaves insertions have only been studied occasionally. Therefore, the aim of this work was the quantification of the active compounds content in the leaves pairs of Mentha × villosa Huds. cv. Snežná, using pharmacopoeial methods: total hydroxycinnamic derivatives expressed as rosmarinic acid (THD) and luteolin-type flavonoids. THD content ranged from 6.7% to 9.4% in the leaves pairs water extracts, and from 6.6% to 14.0% in methanol extracts. Flavonoids contents, expressed as luteolin-7-O-glucoside, ranged from 4.0% to 8.8% in water extracts, and from 4.0% to 10.5% in methanol extracts. Antioxidant activity (DPPH) expressed as SC50 ranged from 10.2 to 16.9 μg.ml-1 (drug dry weight) in water extracts, and from 10.7 to 21.6 μg.ml-1 in methanol extracts. The highest content of phenolic compounds as well as the highest antioxidant activity were found to be in the top sheet, while the lowest content of phenolic compounds and lowest antioxidant activity were detected in the leaves of the middle stem part.Key words: Mentha × villosa Huds cv. Snežná hydroxycinnamic derivatives rosmarinic acid luteolin-7-O-glucoside DPPH.

  19. IBS and the role of otilonium bromide.

    Science.gov (United States)

    Boeckxstaens, Guy; Corazziari, Enrico S; Mearin, Fermín; Tack, Jan

    2013-03-01

    Awareness of the seriousness of irritable bowel disorder (IBS) remains low among clinicians. In this review, we summarize the current knowledge of IBS and highlight the major personal, economic, and social burden of the disease, and the importance of adequate treatment of what is still often viewed as a trivial disorder. In fact, IBS is a major reason for referral. It is crucial that the varied pathophysiologies of this complex heterogeneous disease are understood in order to be able to treat both the presenting symptoms (pain, bloating, flatulence, abnormal defecation, diarrhea, constipation) and the underlying disorder effectively. Low-grade inflammatory and immune activation has been observed, but the precise triggers and mechanisms, and the relevance to symptom generation, remain to be established. IBS patients require different treatment strategies according to the pattern, severity, frequency, and symptoms. While initial therapy traditionally targets the most bothersome symptom, long-term therapy aims at maintaining symptom control and preventing recurrence. In addition to dietary/lifestyle interventions and psychosocial strategies, a wide range of pharmacologic therapies are approved for use in IBS depending on the symptoms reported. Musculotropic spasmolytics, which act directly on intestinal smooth muscle contractility, such as otilonium bromide, are effective, particularly in the relief of abdominal pain and bloating, and are well tolerated in IBS. THE OBIS TRIAL: The recent large placebo-controlled Otilonium Bromide in Irritable Bowel Syndrome study demonstrated the superiority of otilonium bromide versus placebo not only in the reduction of pain and bloating, but also in protection from relapse due to the long-lasting effect.

  20. The Effect of AGN and SNe Feedback on Star Formation,Reionization and the Near Infrared Background

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Feedback from supernovae (SNe) and from active galactic nuclei (AGN) accom-panies the history of star formation and galaxy evolution. We present an analytic model to explain how and when the SNe and AGN exert their feedback effects on the star formation and galaxy evolution processes. By using SNe and AGN kinetic feedback mechanisms based on the Lambda Cold Dark Matter (LCDM) model, we explore how these feedback mecha-nisms affect the star formation history (SFH), the Near-Infrared Background (NIRB) flux and the cosmological reionization. We find the values of the feedback strengths, ∈AGN =1.0+0.50.3and ∈SN=0.04+0.02-0.02, can provide a reasonable explanation of most of the observational re-suits, and that the AGN feedback effect on star formation history is quite different from the SNe feedback at high redshifts. Our conclusions manifest quantitatively that these feedback effects decrease star formation rate density (SFRD) and the NIRB flux (in 1.4 - 4.0μm), and postpone the time of completion of the cosmological reionization.

  1. Oneindigheid van het IC Design

    NARCIS (Netherlands)

    Annema, Anne-Johan

    2005-01-01

    In de IC-elektronica is het begrip oneindig (en zijn alter-ego nul) al vele jaren zowel de rode draad als de grote leidraad: er worden steeds weer nieuwere technologieën en (systeem- en circuit)principes ontwikkeld om dichter bij het gewenste nulpunt en dichter bij de nagestreefde oneindigheid te ge

  2. ICS - i et minoritetsetnisk perspektiv

    DEFF Research Database (Denmark)

    Koldsø, Birgit Raundahl

    ICS anvendes i hovedparten af landets kommuner, som en generel socialfaglig metode i sagsbehandlingen omkring udsatte børn, unge og deres familier. Imidlertid findes der ingen forskning, erfaringsopsamling, evaluering eller systematiseret viden fra dansk kontekst, der sætter fokus på anvendelse a...

  3. Bayesian Statistics and Parameter Constraints on the Generalized Chaplygin Gas Model using SNe Ia Data

    CERN Document Server

    Colistete, R C; Goncalves, S V B

    2004-01-01

    The type Ia supernovae (SNe Ia) observational data are used to estimate the parameters of a cosmological model with cold dark matter and the generalized Chaplygin gas model (GCGM). The GCGM depends essentially on five parameters: the Hubble constant, the parameter $\\bar{A}$ related to the velocity of the sound, the equation of state parameter $\\alpha$, the curvature of the Universe and the fraction density of the generalized Chaplygin gas (or the cold dark matter). The parameter $\\alpha$ is allowed to take negative values and to be greater than 1. The Bayesian parameter estimation yields $\\alpha = - 0.86^{+6.01}_{-0.15}$, $H_0 = 62.0^{+1.32}_{-1.42} km/Mpc.s$, $\\Omega _{k0}=-1.26_{-1.42}^{+1.32}$, $\\Omega_{m0} = 0.00^{+0.86}_{-0.00}$, $\\Omega_{c0} = 1.39^{+1.21}_{-1.25}$, $\\bar A =1.00^{+0.00}_{-0.39}$, $t_0 = 15.3^{+4.2}_{-3.2}$ and $q_0 = -0.80^{+0.86}_{-0.62}$, where $t_0$ is the age of the Universe and $q_0$ is the value of the deceleration parameter today. Our results indicate that a Universe completely ...

  4. Snežna jama (Slovenia): Interdisciplinary dating of cave sediments and implication for landscape evolution

    Science.gov (United States)

    Häuselmann, Philipp; Mihevc, Andrej; Pruner, Petr; Horáček, Ivan; Čermák, Stanislav; Hercman, Helena; Sahy, Diana; Fiebig, Markus; Hajna, Nadja Zupan; Bosák, Pavel

    2015-10-01

    Caves are important markers of surface evolution, since they are, as a general rule, linked with ancient valley bottoms by their springs. However, caves can only be dated indirectly by means of the sediments they contain. If the sediment is older than common dating methods, one has to use multiple dating approaches in order to get meaningful results. U/Th dating, palaeomagnetic analysis of flowstone and sediment profiles, cosmogenic dating of quartz pebbles, and mammalian dating allowed a robust estimate of speleogenesis, sediment deposition, climatic change at the surface, and uplift history on the Periadriatic fault line during the Plio-Pleistocene. Our dates indicate that Snežna jama was formed in the (Upper) Miocene, received its sedimentary deposits during the Pliocene in a rather low-lying, hilly landscape, and became inactive due to uplift along the Periadriatic and Sava faults and climatic changes at the beginning of the Quaternary. Although it is only a single cave, the information contained within it makes it an important site of the Southern Alps.

  5. Snežna jama (Slovenia): Interdisciplinary dating of cave sediments and implication for landscape evolution

    Science.gov (United States)

    Häuselmann, Philipp; Mihevc, Andrej; Pruner, Petr; Horáček, Ivan; Čermák, Stanislav; Hercman, Helena; Sahy, Diana; Fiebig, Markus; Hajna, Nadja Zupan; Bosák, Pavel

    2015-01-01

    Caves are important markers of surface evolution, since they are, as a general rule, linked with ancient valley bottoms by their springs. However, caves can only be dated indirectly by means of the sediments they contain. If the sediment is older than common dating methods, one has to use multiple dating approaches in order to get meaningful results. U/Th dating, palaeomagnetic analysis of flowstone and sediment profiles, cosmogenic dating of quartz pebbles, and mammalian dating allowed a robust estimate of speleogenesis, sediment deposition, climatic change at the surface, and uplift history on the Periadriatic fault line during the Plio-Pleistocene. Our dates indicate that Snežna jama was formed in the (Upper) Miocene, received its sedimentary deposits during the Pliocene in a rather low-lying, hilly landscape, and became inactive due to uplift along the Periadriatic and Sava faults and climatic changes at the beginning of the Quaternary. Although it is only a single cave, the information contained within it makes it an important site of the Southern Alps. PMID:26516294

  6. Cosmic expansion history from SNe Ia data via information field theory: the charm code

    Science.gov (United States)

    Porqueres, Natàlia; Enßlin, Torsten A.; Greiner, Maksim; Böhm, Vanessa; Dorn, Sebastian; Ruiz-Lapuente, Pilar; Manrique, Alberto

    2017-03-01

    We present charm (cosmic history agnostic reconstruction method), a novel inference algorithm that reconstructs the cosmic expansion history as encoded in the Hubble parameter H(z) from SNe Ia data. The novelty of the approach lies in the usage of information field theory, a statistical field theory that is very well suited for the construction of optimal signal recovery algorithms. The charm algorithm infers non-parametrically s(a) = ln(ρ(a) /ρcrit0), the density evolution which determines H(z), without assuming an analytical form of ρ(a) but only its smoothness with the scale factor a = (1 + z)-1. The inference problem of recovering the signal s(a) from the data is formulated in a fully Bayesian way. In detail, we have rewritten the signal as the sum of a background cosmology and a perturbation. This allows us to determine the maximum a posteriory estimate of the signal by an iterative Wiener filter method. Applying charm to the Union2.1 supernova compilation, we have recovered a cosmic expansion history that is fully compatible with the standard ΛCDM cosmological expansion history with parameter values consistent with the results of the Planck mission.

  7. SiFTO: An Empirical Method for Fitting SNe Ia Light Curves

    CERN Document Server

    Conley, A; Hsiao, E Y; Guy, J; Astier, Pierre; Balam, D; Balland, C; Basa, S; Carlberg, R G; Fouchez, D; Hardin, D; Howell, D A; Hook, I M; Pain, R; Perrett, K; Pritchet, C J; Regnault, N

    2008-01-01

    We present SiFTO, a new empirical method for modeling type Ia supernovae (SNe Ia) light curves by manipulating a spectral template. We make use of high-redshift SN observations when training the model, allowing us to extend it bluer than rest frame U. This increases the utility of our high-redshift SN observations by allowing us to use more of the available data. We find that when the shape of the light curve is described using a stretch prescription, applying the same stretch at all wavelengths is not an adequate description. SiFTO therefore uses a generalization of stretch which applies different stretch factors as a function of both the wavelength of the observed filter and the stretch in the rest-frame B band. We compare SiFTO to other published light-curve models by applying them to the same set of SN photometry, and demonstrate that SiFTO and SALT2 perform better than the alternatives when judged by the scatter around the best fit luminosity distance relationship. We further demonstrate that when SiFTO ...

  8. Intestinal Microbiota And Diet in IBS: Causes, Consequences, or Epiphenomena?

    NARCIS (Netherlands)

    Rajilic-Stojanovic, M.; Jonkers, D.M.; Salonen, A.; Hanevik, K.; Raes, J.; Jalanka, J.; de Vos, W.M.; Manichanh, C.; Golic, N.; Enck, P.; Philippou, E.; Iraqi, F.A.; Clarke, G.; Spiller, R.C.; Penders, J.

    2015-01-01

    Irritable bowel syndrome (IBS) is a heterogeneous functional disorder with a multifactorial etiology that involves the interplay of both host and environmental factors. Among environmental factors relevant for IBS etiology, the diet stands out given that the majority of IBS patients report their sym

  9. Three-dimensional IC trends

    Energy Technology Data Exchange (ETDEWEB)

    Akasaka, Y.

    1986-12-01

    VLSI will be reaching to the limit of minimization in the 1990s, and after that, further increase of packing density or functions might depend on the vertical integration technology. Three-dimensional (3-D) integration is expected to provide several advantages, such as 1) parallel processing, 2) high-speed operation, 3) high packing density, and 4) multifunctional operation. Basic technologies of 3-D IC are to fabricate SOI layers and to stack them monolithically. Crystallinity of the recrystallized layer in SOI has increasingly become better, and very recently crystal-axis controlled, defect-free single-crystal areas has been obtained in chip size level by laser recystallization technology. Some basic functional models showing the concept or image of a future 3-D IC were fabricated in two or three stacked active layers. Some other proposals of subsystems in the application of 3-D structure, and the technical issues for realizing practical 3-D IC, i.e., the technology for fabricating high-quality SOI crystal on complicated surface topology, crosstalk of the signals between the stacked layers, total power consumption and cooling of the chip, are also discussed in this paper.

  10. IC-index and maximum IC-colorings of double-stars%双星图的 IC-指数及极大 IC-着色

    Institute of Scientific and Technical Information of China (English)

    姜臻颖

    2014-01-01

    The problem of IC-coloring of double-stars is studied .It concludes a lower bound of the IC-in-dex of double-starts by showing a kind of IC-coloring above all ,then a upper bound of IC-index is ob-teined based on the definition of maximum IC-coloring .Since the upper bound and lower bound are e-qual ,the IC-index is determined ,thus two kinds of maximum IC-colorings of double-stars is proved .%研究了双星图的IC-着色问题。首先通过给出双星图一种IC-着色,得到其IC-指数的下界,再从极大IC-着色的定义出发,得到了IC-指数的上界。由上下界相等得到了双星图的IC-指数,从而证明了其2种极大IC-着色方案。

  11. Long gamma-ray Bursts and Type Ic Core CollapseSupernovae have Similar Environments

    Energy Technology Data Exchange (ETDEWEB)

    Kelly, P.L.; Kirshner, R.P.; Pahre, M.

    2007-12-04

    When the afterglow fades at the site of a long-duration {gamma}-ray burst (LGRB), Type Ic supernovae (SN Ic) are the only type of core collapse supernova observed. Recent work found that a sample of LGRB had different environments from a collection of core-collapse supernovae identified in a high-redshift sample from colors and light curves. LGRB were in the brightest regions of their hosts, but the core-collapse sample followed the overall distribution of the galaxy light. Here we examine 263 fully spectroscopically-typed supernovae found in nearby (z < 0.06) galaxies for which we have constructed surface photometry from the Sloan Digital Sky Survey (SDSS). The distributions of the thermonuclear supernovae (SN Ia) and some varieties of core-collapse supernovae (SN II and SN Ib) follow the galaxy light, but the SN Ic (like LGRB) are much more likely to erupt in the brightest regions of their hosts. The high-redshift hosts of LGRB are overwhelmingly irregulars, without bulges, while many low redshift SN Ic hosts are spirals with small bulges. When we remove the bulge light from our low-redshift sample, the SN Ic and LGRB distributions agree extremely well. If both LGRB and SN Ic stem from very massive stars, then it seems plausible that the conditions necessary for forming SN Ic are also required for LGRB. Additional factors, including metallicity, may determine whether the stellar evolution of a massive star leads to a LGRB with an underlying broad-lined SN Ic, or simply a SN Ic without a {gamma}-ray burst.

  12. [The gastrointestinal motor function in irritable bowel syndrome (IBS)].

    Science.gov (United States)

    Sagami, Yasuhiro; Hongo, Michio

    2006-08-01

    Irritable bowel syndrome (IBS) is presumed to be a gastrointestinal motility disorder with the brain-gut interaction. Psychological stress and stimuli of the colonic lumen increase colonic motor function which is exaggerated in IBS patients. Corticotropin-releasing hormone (CRH) is considered to be a major mediator of stress responses in the brain-gut interaction. Similarly, peripheral administration of CRH affects colonic motility, induces abdominal symptoms and stimulates ACTH secretion, all of which are exaggerated in IBS patients. CRH antagonist blocks the greater responses of colonic motility in IBS. CRH is a key peptide in the pathophysiology of IBS with the brain-gut interaction.

  13. 75 FR 54940 - Agency Information Collection (IC) Activities; Revision of an Approved IC; Accident Recordkeeping...

    Science.gov (United States)

    2010-09-09

    ... Federal Motor Carrier Safety Administration Agency Information Collection (IC) Activities; Revision of an Approved IC; Accident Recordkeeping Requirements AGENCY: Federal Motor Carrier Safety Administration (FMCSA... revision of the Information Collection (IC) entitled, ``Accident Recordkeeping Requirements,''...

  14. Intestinal microbiota and its role in irritable bowel syndrome (IBS).

    Science.gov (United States)

    Ohman, Lena; Simrén, Magnus

    2013-05-01

    Gut microbiota alterations are increasingly being recognized as an important factor in the pathogenesis and pathophysiology of Irritable bowel syndrome (IBS). The onset of IBS symptoms after a bout of gastroenteritis comprises one of the strongest indications for the importance of gut microbiota for IBS. Moreover, recent studies have identified several susceptibility genes for IBS involved in the innate immunity and recognition of bacteria but also maintaining the integrity of the intestinal barrier. During recent years, it has also been demonstrated that IBS patients, or subgroups thereof, may have an altered microbiota composition relative to healthy individuals, mainly based on the analysis of fecal microbiota. Moreover, a positive effect of treatment with non-absorbable antibiotics and probiotics in IBS provides further indirect support for the relevance of gut microbiota alterations in IBS.

  15. Institutional computing (IC) information session

    Energy Technology Data Exchange (ETDEWEB)

    Koch, Kenneth R [Los Alamos National Laboratory; Lally, Bryan R [Los Alamos National Laboratory

    2011-01-19

    The LANL Institutional Computing Program (IC) will host an information session about the current state of unclassified Institutional Computing at Los Alamos, exciting plans for the future, and the current call for proposals for science and engineering projects requiring computing. Program representatives will give short presentations and field questions about the call for proposals and future planned machines, and discuss technical support available to existing and future projects. Los Alamos has started making a serious institutional investment in open computing available to our science projects, and that investment is expected to increase even more.

  16. Computing fundamentals IC3 edition

    CERN Document Server

    Wempen, Faithe

    2014-01-01

    Kick start your journey into computing and prepare for your IC3 certification With this essential course book you'll be sending e-mails, surfing the web and understanding the basics of computing in no time. Written by Faithe Wempen, a Microsoft Office Master Instructor and author of more than 120 books, this complete guide to the basics has been tailored to provide comprehensive instruction on the full range of entry-level computing skills. It is a must for students looking to move into almost any profession, as entry-level computing courses have become a compulsory requirement in the modern w

  17. Reconstruction of the interaction term between dark matter and dark energy using SNe Ia

    Energy Technology Data Exchange (ETDEWEB)

    Solano, Freddy Cueva; Nucamendi, Ulises, E-mail: freddy@ifm.umich.mx, E-mail: ulises@ifm.umich.mx [Instituto de Física y Matemáticas, Universidad Michoacana de San Nicolás de Hidalgo, Edificio C-3, Ciudad Universitaria, CP. 58040, Morelia, Michoacán (Mexico)

    2012-04-01

    We apply a parametric reconstruction method to a homogeneous, isotropic and spatially flat Friedmann-Robertson-Walker (FRW) cosmological model filled of a fluid of dark energy (DE) with constant equation of state (EOS) parameter interacting with dark matter (DM)\\@. The reconstruction method is based on expansions of the general interaction term and the relevant cosmological variables in terms of Chebyshev polynomials which form a complete set orthonormal functions. This interaction term describes an exchange of energy flow between the DE and DM within dark sector. To show how the method works we do the reconstruction of the interaction function expanding it in terms of only the first six Chebyshev polynomials and obtain the best estimation for the coefficients of the expansion assuming three models: (a) a DE equation of the state parameter w = −1 (an interacting cosmological Λ), (b) a DE equation of the state parameter w = constant with a dark matter density parameter fixed, (c) a DE equation of the state parameter w = constant with a free constant dark matter density parameter to be estimated, and using the Union2 SNe Ia data set from ''The Supernova Cosmology Project'' (SCP) composed by 557 type Ia supernovae. In both cases, the preliminary reconstruction shows that in the best scenario there exist the possibility of a crossing of the noninteracting line Q = 0 in the recent past within the 1σ and 2σ errors from positive values at early times to negative values at late times. This means that, in this reconstruction, there is an energy transfer from DE to DM at early times and an energy transfer from DM to DE at late times. We conclude that this fact is an indication of the possible existence of a crossing behavior in a general interaction coupling between dark components.

  18. The Galah Survey: Classification and Diagnostics with t-SNE Reduction of Spectral Information

    Science.gov (United States)

    Traven, G.; Matijevič, G.; Zwitter, T.; Žerjal, M.; Kos, J.; Asplund, M.; Bland-Hawthorn, J.; Casey, A. R.; De Silva, G.; Freeman, K.; Lin, J.; Martell, S. L.; Schlesinger, K. J.; Sharma, S.; Simpson, J. D.; Zucker, D. B.; Anguiano, B.; Da Costa, G.; Duong, L.; Horner, J.; Hyde, E. A.; Kafle, P. R.; Munari, U.; Nataf, D.; Navin, C. A.; Reid, W.; Ting, Y.-S.

    2017-02-01

    Galah is an ongoing high-resolution spectroscopic survey with the goal of disentangling the formation history of the Milky Way using the fossil remnants of disrupted star formation sites that are now dispersed around the Galaxy. It is targeting a randomly selected magnitude-limited (V ≤ 14) sample of stars, with the goal of observing one million objects. To date, 300,000 spectra have been obtained. Not all of them are correctly processed by parameter estimation pipelines, and we need to know about them. We present a semi-automated classification scheme that identifies different types of peculiar spectral morphologies in an effort to discover and flag potentially problematic spectra and thus help to preserve the integrity of the survey results. To this end, we employ the recently developed dimensionality reduction technique t-SNE (t-distributed stochastic neighbor embedding), which enables us to represent the complex spectral morphology in a two-dimensional projection map while still preserving the properties of the local neighborhoods of spectra. We find that the majority (178,483) of the 209,533 Galah spectra considered in this study represents normal single stars, whereas 31,050 peculiar and problematic spectra with very diverse spectral features pertaining to 28,579 stars are distributed into 10 classification categories: hot stars, cool metal-poor giants, molecular absorption bands, binary stars, Hα/Hβ emission, Hα/Hβ emission superimposed on absorption, Hα/Hβ P-Cygni, Hα/Hβ inverted P-Cygni, lithium absorption, and problematic. Classified spectra with supplementary information are presented in the catalog, indicating candidates for follow-up observations and population studies of the short-lived phases of stellar evolution.

  19. Can Dust Injected by SNe Explain the NIR-MIR Excess in Young Massive Stellar Clusters?

    Science.gov (United States)

    Martínez-González, Sergio; Wünsch, Richard; Palouš, Jan

    2017-07-01

    We present a physically motivated model involving the different processes affecting supernova dust grains as they are incorporated into the thermalized medium within young massive star clusters. The model is used to explain the near- to mid-infrared (NIR-MIR) excess found in such clusters and usually modeled as a blackbody with temperature ˜ (400{--}1000) K. In our approach, dust grains are efficiently produced in the clumpy ejecta of core-collapse supernovae, shattered into small pieces (≲ 0.05 μm) as they are incorporated into the hot and dense ISM, heated via frequent collisions with electrons and the absorption of energetic photons. Grains with small sizes can more easily acquire the high temperatures (˜1000 K) required to produce an NIR-MIR excess with respect to the emission of foreground PAHs and starlight. However, the extreme conditions inside young massive clusters make it difficult for these small grains to have a persistent manifestation at NIR-MIR wavelengths as they are destroyed by efficient thermal sputtering. Nevertheless, the chances for a persistent manifestation are increased by taking into account that small grains become increasingly transparent to their impinging ions as their sizes decrease. For an individual SN event, we find that the NIR-MIR excess lasts longer if the time required to incorporate all the grains into the thermalized medium is also longer, and, in some cases, comparable to the characteristic interval between supernova explosions. Our models can successfully explain the near-infrared excesses found in the star clusters observed in M33 assuming a low heating efficiency and mass loading. In this scenario, the presence of the NIR-MIR excess is an indication of efficient dust production in SNe and its subsequent destruction.

  20. Spectral luminosity indicators in SNe Ia - Understanding the R(SiII) line strength ratio and beyond

    CERN Document Server

    Hachinger, Stephan; Tanaka, Masaomi; Hillebrandt, Wolfgang; Benetti, Stefano

    2008-01-01

    SNe Ia are good distance indicators because the shape of their light curves, which can be measured independently of distance, varies smoothly with luminosity. This suggests that SNe Ia are a single family of events. Similar correlations are observed between luminosity and spectral properties. In particular, the ratio of the strengths of the SiII \\lambda 5972 and \\lambda 6355 lines, known as R(SiII), was suggested as a potential luminosity indicator. Here, the physical reasons for the observed correlation are investigated. A Monte-Carlo code is used to construct a sequence of synthetic spectra resembling those of SNe with different luminosities near B maximum. The influence of abundances and of ionisation and excitation conditions on the synthetic spectral features is investigated. The ratio R(SiII) depends ssentially on the strength of SiII \\lambda 5972, because SiII \\lambda 6355 is saturated. In less luminous objects, SiII \\lambda 5972 is stronger because of a rapidly increasing SiII/SiIII ratio. Thus, the c...

  1. Using the local gas-phase oxygen abundances to explore a metallicity-dependence in SNe Ia luminosities

    CERN Document Server

    Moreno-Raya, M E; Molla, M; Galbany, L; Vilchez, J M; Carnero, A

    2016-01-01

    We present an analysis of the gas-phase oxygen abundances of a sample of 28 galaxies in the local Universe (z < 0.02) hosting Type Ia Supernovae (SNe Ia). The data were obtained with the 4.2m William Herschel Telescope (WHT). We derive local oxygen abundances for the regions where the SNe Ia exploded by calculating oxygen gradients through each galaxy (when possible) or assuming the oxygen abundance of the closest HII region. The sample selection only considered galaxies for which distances not based on the the SN Ia method are available. Then, we use a principal component analysis to study the dependence of the absolute magnitudes on the color of the SN Ia, the oxygen abundances of the region where they exploded, and the stretch of the SN light curve. We demonstrate that our previous result suggesting a metallicity-dependence on the SN Ia luminosity for not-reddened SNe Ia (Moreno-Raya et al. 2016) can be extended to our whole sample. These results reinforce the need of including a metallicity proxy, such...

  2. SEM probe of IC radiation sensitivity

    Science.gov (United States)

    Gauthier, M. K.; Stanley, A. G.

    1979-01-01

    Scanning Electron Microscope (SEM) used to irradiate single integrated circuit (IC) subcomponent to test for radiation sensitivity can localize area of IC less than .03 by .03 mm for determination of exact location of radiation sensitive section.

  3. Ib & Jørgen Rasmussen Arkitekter

    DEFF Research Database (Denmark)

    Lund, Nils-Ole

    2007-01-01

    1960’erne og 1970’erne var der stort set ikke den arkitektkonkurrence, hvor tvillingerne Ib & Jørgen ikke fik en placering eller et indkøb, og dette sprudlende og talentfulde arkitektpar har nu fået den portrætbog, de så længe har fortjent. Henved 100 énfamiliehuse og markante hovedværker som Sol...

  4. Two Type Ic supernovae in low-metallicity, dwarf galaxies: diversity of explosions

    CERN Document Server

    Young, D R; Valenti, S; Pastorello, A; Benetti, S; Benn, C R; Bersier, D; Botticella, M T; Corradi, R L M; Harutyunyan, A H; Hrudkova, M; Hunter, I; Mattila, S; de Mooij, E J W; Navasardyan, H; Snellen, I A G; Tanvir, N R; Zampieri, L

    2009-01-01

    We present BVRI photometry and optical spectroscopy of two Type Ic supernovae SN 2007bg and SN 2007bi discovered in wide-field, non-targeted surveys and associated with sub-luminous blue dwarf galaxies. Neither SNe 2007bg nor 2007bi were found in association with an observed GRB, but are found to inhabit similar low-metallicity environments as GRB associated supernovae. The radio-bright SN 2007bg is hosted by an extremely sub-luminous galaxy of magnitude MB = -12.4+/-0.6 mag with an estimated oxygen abundance of 12+log(O/H) = 8.18+/-0.17. The lightcurve of SN 2007bg displays one of the fastest post-maximum decline rates of all broad-lined Type Ic supernovae known to date and, when combined with its high expansion velocities, a high kinetic energy to ejected mass ratio (E_K/Mej ~ 2.7). We show that SN 2007bi is possibly the most luminous Type Ic known, reaching a peak magnitude of MR ~ 21.3 mag and displays a remarkably slow decline, following the radioactive decay rate of 56Co to 56Fe throughout the course of...

  5. Photometric study of IC 2156

    CERN Document Server

    Tadross, A L

    2015-01-01

    The optical UBVRI photometric analysis has been established using SLOAN DIGITAL SKY SURVEY (SDSS database) in order to estimate the astrophysical parameters of poorly studied open star cluster IC 2156. The results of the present study are compared with a previous one of ours, which relied on the 2MASS JHK infrared photometry. The stellar density distributions and color-magnitude diagrams of the cluster are used to determine the geometrical structure; limited radius, core and tidal radii, the distances from the Sun, from the Galactic plane and from the Galactic center. Also, the main photometric parameters; age, distance modulus, color excesses, membership, total mass, luminosity, mass functions and relaxation time; have been estimated.

  6. Spitzer Observations of IC 2118

    CERN Document Server

    Guieu, S; Stauffer, J R; Vrba, F J; Noriega-Crespo, A; Spuck, T; Moody, T Roelofsen; Sepulveda, B; Weehler, C; Maranto, A; Cole, D M; Flagey, N; Laher, R; Penprase, B; Ramirez, S; Stolovy, S

    2010-01-01

    IC 2118, also known as the Witch Head Nebula, is a wispy, roughly cometary, ~5 degree long reflection nebula, and is thought to be a site of triggered star formation. In order to search for new young stellar objects (YSOs), we have observed this region in 7 mid- and far-infrared bands using the Spitzer Space Telescope and in 4 bands in the optical using the U. S. Naval Observatory 40-inch telescope. We find infrared excesses in 4 of the 6 previously-known T Tauri stars in our combined infrared maps, and we find 6 entirely new candidate YSOs, one of which may be an edge-on disk. Most of the YSOs seen in the infrared are Class II objects, and they are all in the "head" of the nebula, within the most massive molecular cloud of the region.

  7. Cepheid Calibration of the Peak Brightness of SNe Ia. V. SN 1981B in NGC 4536

    Science.gov (United States)

    Saha, A.; Sandage, Allan; Labhardt, Lukas; Tammann, G. A.; Macchetto, F. D.; Panagia, N.

    1996-07-01

    Observations have been made with the Hubble Space Telescope between 1994 June and August over a 67 day interval, comprising 17 epochs in the F555W band and 5 epochs in the F814W band. The target was a region of an outlying spiral arm of NGC 4536 [Sbc(s)I-II), a galaxy that was parent to the type Ia supernova SN 1981B. Seventy-three Cepheids were found with periods ranging between 5.4 and 65 days. The apparent distance modulus of NGC 4536 is (m - M)_AV_ = 31.23 +/- 0.05 and (m - M)_AB_ = 31.27 +/- 0.05. There is no statistically significant differential absorption between the Cepheids inside and outside the spiral arm, or between the Cepheids and the position of the supernova (SN). The resulting absolute magnitudes of SN 1981B are M_V_(max) = - 19.32 +/- 0.12 and M_B_(max) = - 19.29 +/- 0.13 using the apparent modulus of NGC 4536 and the apparent magnitudes of SN 1981B as if there is no differential extinction between them. If we correct the SN for reddening, determined independently of the Cepheids, and then use the true modulus of NGC 4536 of (m - M)_0_ = 31.10 +/- 0.13, the SN values are M_B_(max) = - 19.46 +/- 0.24 and M_V_(max) = - 19.44 +/- 0.21. Combining these calibrations With the three calibrations previously available for the SNe 1895B, 1937C, and 1972E, determined in the first four papers of this series, gives the interim calibrations of = - 19.48 +/- 0.12 and = - 19.47 +/- 0.10. These require interim Hubble constants of H_0_(B) = 55 +/- 3(internal) km s^-1^ Mpc^-1^, and H_0_(V) = 58 +/- 3(internal) km s^-1^ Mpc^-1^. Improvement is expected when the fifth and sixth calibrators, SN 1960F in NGC 4496A and SN 1990N in NGC 4639, are added to the four available here. When these data are available, any putative decay rate-absolute magnitude correlation can also begin to be studied directly from the Cepheid calibrations themselves.

  8. Mod 1 ICS TI Report: ICS Conversion of a 140% HPGe Detector

    Energy Technology Data Exchange (ETDEWEB)

    Bounds, John Alan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-07-05

    This report evaluates the Mod 1 ICS, an electrically cooled 140% HPGe detector. It is a custom version of the ORTEC Integrated Cooling System (ICS) modified to make it more practical for us to use in the field. Performance and operating characteristics of the Mod 1 ICS are documented, noting both pros and cons. The Mod 1 ICS is deemed a success. Recommendations for a Mod 2 ICS, a true field prototype, are provided.

  9. Integrated Baseline System (IBS) Version 2.0: User guide

    Energy Technology Data Exchange (ETDEWEB)

    Bower, J.C. [Bower Software Services, Kennewick, WA (United States); Burford, M.J.; Downing, T.R.; Matsumoto, S.W.; Schrank, E.E.; Williams, J.R.; Winters, C.; Wood, B.M.

    1994-03-01

    The Integrated Baseline System (IBS) is an emergency management planning and analysis tool being developed under the direction of the Federal Emergency Management Agency. This User Guide explains how to start and use the IBS Program, which is designed to help civilian emergency management personnel to plan for and support their responses to a chemical-releasing event at a military chemical stockpile. The intended audience for this document is all users of the IBS, especially emergency management planners and analysts.

  10. VizieR Online Data Catalog: CfA4: light curves for 94 type Ia SNe (Hicken+, 2012)

    Science.gov (United States)

    Hicken, M.; Challis, P.; Kirshner, R. P.; Rest, A.; Cramer, C. E.; Wood-Vasey, W. M.; Bakos, G.; Berlind, P.; Brown, W. R.; Caldwell, N.; Calkins, M.; Currie, T.; de Kleer, K.; Esquerdo, G.; Everett, M.; Falco, E.; Fernandez, J.; Friedman, A. S.; Groner, T.; Hartman, J.; Holman, M. J.; Hutchins, R.; Keys, S.; Kipping, D.; Latham, D.; Marion, G. H.; Narayan, G.; Pahre, M.; Pal, A.; Peters, W.; Perumpilly, G.; Ripman, B.; Sipocz, B.; Szentgyorgyi, A.; Tang, S.; Torres, M. A. P.; Vaz, A.; Wolk, S.; Zezas, A.

    2012-07-01

    The CfA4 sample consists of 5522 light-curve points. All 94 SNe have BVr'i' measurements, while 14 have U and 12 have u'. The CfA4 data were obtained on the 1.2m telescope at the FLWO using the single-chip, four-amplifier CCD KeplerCam. CfA4 data processing followed the same three steps used for CfA3: reduction, calibration, and host-galaxy subtraction (see Hicken et al. 2009, Cat. J/ApJ/700/331 for a more detailed treatment). (4 data files).

  11. TSH elevations as the first laboratory evidence for pseudohypoparathyroidism type Ib (PHP-Ib)†

    Science.gov (United States)

    Molinaro, Angelo; Tiosano, Dov; Takatani, Rieko; Chrysis, Dionisios; Russell, William; Koscielniak, Nikolas; Kottler, Marie-Laure; Agretti, Patrizia; De Marco, Giuseppina; Ahtiainen, Petteri; Christov, Marta; Mäkitie, Outi; Tonacchera, Massimo; Jüppner, Harald

    2014-01-01

    Hypocalcemia and hyperphosphatemia because of resistance towards parathyroid hormone (PTH) in the proximal renal tubules are the most prominent abnormalities in patients affected by pseudohypoparathyroidism type Ib (PHP-Ib). In this rare disorder that is caused by GNAS methylation changes, resistance can occur towards other hormones, such as thyroid-stimulating hormone (TSH), that mediate their actions through G protein-coupled receptors. However, these additional laboratory abnormalities are usually not recognized until PTH-resistant hypocalcemia becomes clinically apparent. We now describe four pediatric patients, first diagnosed with subclinical or overt hypothyroidism between the ages of 0.2 and 15 years, who developed overt PTH-resistance 3-20 years later. Although anti-TPO antibodies provided a plausible explanation for hypothyroidism in one of these patients, this and two other patients revealed broad epigenetic GNAS abnormalities, which included loss of methylation (LOM) at exons AS, XL and A/B, and gain of methylation at exon NESP55, i.e. findings consistent with PHP-Ib. LOM at GNAS exon A/B alone led in the fourth patient to the identification of a maternally inherited 3-kb STX16 deletion, a well-established cause of autosomal dominant PHP-Ib. Although GNAS methylation changes were not detected in additional pediatric and adult patients with subclinical hypothyroidism (23 pediatric and 39 adult cases), hypothyroidism can obviously be the initial finding in PHP-Ib patients. One should therefore consider measuring PTH, along with calcium and phosphate, in patients with unexplained hypothyroidism for extended periods of time to avoid hypocalcemia and associated clinical complications. PMID:25403028

  12. TSH elevations as the first laboratory evidence for pseudohypoparathyroidism type Ib (PHP-Ib).

    Science.gov (United States)

    Molinaro, Angelo; Tiosano, Dov; Takatani, Rieko; Chrysis, Dionisios; Russell, William; Koscielniak, Nikolas; Kottler, Marie-Laure; Agretti, Patrizia; De Marco, Giuseppina; Ahtiainen, Petteri; Christov, Marta; Mäkitie, Outi; Tonacchera, Massimo; Jüppner, Harald

    2015-05-01

    Hypocalcemia and hyperphosphatemia because of resistance toward parathyroid hormone (PTH) in the proximal renal tubules are the most prominent abnormalities in patients affected by pseudohypoparathyroidism type Ib (PHP-Ib). In this rare disorder, which is caused by GNAS methylation changes, resistance can occur toward other hormones, such as thyroid-stimulating hormone (TSH), that mediate their actions through G protein-coupled receptors. However, these additional laboratory abnormalities are usually not recognized until PTH-resistant hypocalcemia becomes clinically apparent. We now describe four pediatric patients, first diagnosed with subclinical or overt hypothyroidism between the ages of 0.2 and 15 years, who developed overt PTH-resistance 3 to 20 years later. Although anti-thyroperoxidase (anti-TPO) antibodies provided a plausible explanation for hypothyroidism in one of these patients, this and two other patients revealed broad epigenetic GNAS abnormalities, which included loss of methylation (LOM) at exons AS, XL, and A/B, and gain of methylation at exon NESP55; ie, findings consistent with PHP-Ib. LOM at GNAS exon A/B alone led in the fourth patient to the identification of a maternally inherited 3-kb STX16 deletion, a well-established cause of autosomal dominant PHP-Ib. Although GNAS methylation changes were not detected in additional pediatric and adult patients with subclinical hypothyroidism (23 pediatric and 39 adult cases), hypothyroidism can obviously be the initial finding in PHP-Ib patients. One should therefore consider measuring PTH, along with calcium and phosphate, in patients with unexplained hypothyroidism for extended periods of time to avoid hypocalcemia and associated clinical complications.

  13. ibérico y cubano

    Directory of Open Access Journals (Sweden)

    Eduard Masjuan BRACONS

    2006-01-01

    Full Text Available Este artículo revisa las interpretaciones que el anarquismo histórico ibérico y cubano tuvieron respecto a la Naturaleza. Intenta explicar las necesidades de existencia que impulsaron la construcción de una nueva cultura de la Naturaleza en los medios obreros desde finales del siglo XIX y hasta los años treinta del siglo XX. Analizo el desarrollo y la orquestación de las ciencias naturales para acceder a una coevolución sustentable con la Naturaleza, a partir de los intermediarios ibéricos de Elisée Reclus, respecto a las relaciones de la sociedad, con el territorio y el agua; así como también la expansión del naturismo ecológico en Cuba. Presento algunas de las aportaciones de esta cultura obrera vinculadas con la Naturaleza, interpretándola en términos culturales, sociales y políticos.

  14. Wafer level 3-D ICs process technology

    CERN Document Server

    Tan, Chuan Seng; Reif, L Rafael

    2009-01-01

    This book focuses on foundry-based process technology that enables the fabrication of 3-D ICs. The core of the book discusses the technology platform for pre-packaging wafer lever 3-D ICs. However, this book does not include a detailed discussion of 3-D ICs design and 3-D packaging. This is an edited book based on chapters contributed by various experts in the field of wafer-level 3-D ICs process technology. They are from academia, research labs and industry.

  15. Newnes digital logic IC pocket book

    CERN Document Server

    MARSTON, R M

    1996-01-01

    This handy reference guide to modern '74'- series and '4000'- series digital ICs presents 620 useful and carefully selected circuits, diagrams, graphs and tables, supported by informative text and captions. Detailed descriptions of and practical applications information on more than 185 TTL and CMOS ICs are provided.This wealth of information is clearly and logically arranged so that specific information can be quickly and easily located. Fifteen chapters cover from IC basics and TTL and CMOS principles, to the practical circuitry of logic ICs, waveform generators and multiplexers.

  16. MULTI-WAVELENGTH OBSERVATIONS OF SUPERNOVA 2011ei: TIME-DEPENDENT CLASSIFICATION OF TYPE IIb AND Ib SUPERNOVAE AND IMPLICATIONS FOR THEIR PROGENITORS

    Energy Technology Data Exchange (ETDEWEB)

    Milisavljevic, Dan; Margutti, Raffaella; Soderberg, Alicia M.; Chomiuk, Laura; Sanders, Nathan E. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Pignata, Giuliano; Bufano, Filomena [Departamento de Ciencias Fisicas, Universidad Andres Bello, Avda. Republica 252, Santiago (Chile); Fesen, Robert A.; Parrent, Jerod T. [Department of Physics and Astronomy, Dartmouth College, 6127 Wilder Lab, Hanover, NH 03755 (United States); Parker, Stuart [Parkdale Observatory, 225 Warren Road, RDl Oxford, Canterbury 7495 (New Zealand); Mazzali, Paolo [Max-Planck-Institut fuer Astrophysik, Karl-Schwarzschild-Strasse 1, D-85748 Garching (Germany); Pian, Elena [Kavli Institute for Theoretical Physics, Kohn Hall, University of California at Santa Barbara, Santa Barbara, CA 93106-4030 (United States); Pickering, Timothy; Buckley, David A. H.; Crawford, Steven M.; Gulbis, Amanda A. S.; Hettlage, Christian [South African Astronomical Observatory, P.O. Box 9, Observatory 7935, Cape Town (South Africa); Hooper, Eric; Nordsieck, Kenneth H. [Department of Astronomy, University of Wisconsin, Madison, WI 53706 (United States); O' Donoghue, Darragh, E-mail: dmilisav@cfa.harvard.edu [Southern African Large Telescope, P.O. Box 9, Observatory 7935, Cape Town (South Africa); and others

    2013-04-10

    We present X-ray, UV/optical, and radio observations of the stripped-envelope, core-collapse supernova (SN) 2011ei, one of the least luminous SNe IIb or Ib observed to date. Our observations begin with a discovery within {approx}1 day of explosion and span several months afterward. Early optical spectra exhibit broad, Type II-like hydrogen Balmer profiles that subside rapidly and are replaced by Type Ib-like He-rich features on a timescale of one week. High-cadence monitoring of this transition suggests absorption attributable to a high-velocity ({approx}> 12, 000 km s{sup -1}) H-rich shell, which is likely present in many Type Ib events. Radio observations imply a shock velocity of v Almost-Equal-To 0.13 c and a progenitor star average mass-loss rate of M-dot {approx}1.4 Multiplication-Sign 10{sup -5} M{sub sun} yr{sup -1} (assuming wind velocity v{sub w} = 10{sup 3} km s{sup -1}). This is consistent with independent constraints from deep X-ray observations with Swift-XRT and Chandra. Overall, the multi-wavelength properties of SN 2011ei are consistent with the explosion of a lower-mass (3-4 M{sub Sun }), compact (R{sub *} {approx}< 1 Multiplication-Sign 10{sup 11} cm), He-core star. The star retained a thin hydrogen envelope at the time of explosion, and was embedded in an inhomogeneous circumstellar wind suggestive of modest episodic mass loss. We conclude that SN 2011ei's rapid spectral metamorphosis is indicative of time-dependent classifications that bias estimates of the relative explosion rates for Type IIb and Ib objects, and that important information about a progenitor star's evolutionary state and mass loss immediately prior to SN explosion can be inferred from timely multi-wavelength observations.

  17. THE FAST AND FURIOUS DECAY OF THE PECULIAR TYPE Ic SUPERNOVA 2005ek

    Energy Technology Data Exchange (ETDEWEB)

    Drout, M. R.; Soderberg, A. M.; Margutti, R.; Milisavljevic, D.; Sanders, N. E.; Chornock, R.; Foley, R. J.; Kirshner, R. P.; Chakraborti, S.; Challis, P.; Friedman, A.; Hicken, M.; Jensen, C. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Mazzali, P. A. [Astrophysics Research Institute, Liverpool John Moores University, CH41 1LD Liverpool (United Kingdom); Parrent, J. T. [Department of Physics and Astronomy, Dartmouth College, 6127 Wilder Laboratory, Hanover, NH 03755 (United States); Filippenko, A. V.; Li, W.; Cenko, S. B.; Ganeshalingam, M. [Department of Astronomy, University of California, Berkeley, CA 94720-3411 (United States); Brown, P. J., E-mail: mdrout@cfa.harvard.edu [Department of Physics and Astronomy, Texas A and M University, College Station, TX 77843-4242 (United States); and others

    2013-09-01

    We present extensive multi-wavelength observations of the extremely rapidly declining Type Ic supernova (SN Ic), SN 2005ek. Reaching a peak magnitude of M{sub R} = -17.3 and decaying by {approx}3 mag in the first 15 days post-maximum, SN 2005ek is among the fastest Type I supernovae observed to date. The spectra of SN 2005ek closely resemble those of normal SN Ic, but with an accelerated evolution. There is evidence for the onset of nebular features at only nine days post-maximum. Spectroscopic modeling reveals an ejecta mass of {approx}0.3 M{sub Sun} that is dominated by oxygen ({approx}80%), while the pseudo-bolometric light curve is consistent with an explosion powered by {approx}0.03 M{sub Sun} of radioactive {sup 56}Ni. Although previous rapidly evolving events (e.g., SN 1885A, SN 1939B, SN 2002bj, SN 2010X) were hypothesized to be produced by the detonation of a helium shell on a white dwarf, oxygen-dominated ejecta are difficult to reconcile with this proposed mechanism. We find that the properties of SN 2005ek are consistent with either the edge-lit double detonation of a low-mass white dwarf or the iron-core collapse of a massive star, stripped by binary interaction. However, if we assume that the strong spectroscopic similarity of SN 2005ek to other SNe Ic is an indication of a similar progenitor channel, then a white-dwarf progenitor becomes very improbable. SN 2005ek may be one of the lowest mass stripped-envelope core-collapse explosions ever observed. We find that the rate of such rapidly declining Type I events is at least 1%-3% of the normal SN Ia rate.

  18. Torsion Cosmology of Poincar\\'e gauge theory and the constraints of its parameters via SNeIa data

    CERN Document Server

    Ao, Xi-Chen

    2011-01-01

    Poincar\\`e gauge theory (PGT) is an alternative gravity theory, which attempts to bring the gravity into the gauge-theoretic frame, where the Lagrangian is quadratic in torsion and curvature. Recently, the cosmological models with torsion based on this theory have drawn many attentions, which try to explain the cosmic acceleration in a new way. Among these PGT cosmological models, the one with only even parity dynamical modes -- SNY model, for its realistic meaning, is very attractive. In this paper, we first analyze the past-time cosmic evolution of SNY model analytically. And based on these results we fit this model to the most comprehensive SNeIa data (Union 2) and thus find the best-fit values of model parameters and initial conditions, whose related $\\chi^{2}$ value is consistent with the one from $\\Lambda$CMD at the 1$\\sigma$ level. Also by the $\\chi^{2}$ estimate, we provide certain constraints on these parameters. Using these best-fit values for the Union 2 SNeIa dataset, we are able to predict the ev...

  19. Interacting scalar tensor cosmology in light of SNeIa, CMB, BAO and OHD observational data sets

    Energy Technology Data Exchange (ETDEWEB)

    Rabiei, Sayed Wrya; Saaidi, Khaled [Faculty of Science University of Kurdistan, Department of Physics, Sanandaj (Iran, Islamic Republic of); Sheikhahmadi, Haidar [Faculty of Science University of Kurdistan, Department of Physics, Sanandaj (Iran, Islamic Republic of); Institute for Advance Studies in Basic Sciences (IASBS) Gava Zang, Zanjan (Iran, Islamic Republic of); Aghamohammadi, Ali [Sanandaj Branch Islamic Azad University, Sanandaj (Iran, Islamic Republic of)

    2016-02-15

    In this work, an interacting chameleon-like scalar field scenario, by considering SNeIa, CMB, BAO, and OHD data sets, is investigated. In fact, the investigation is realized by introducing an ansatz for the effective dark energy equation of state, which mimics the behavior of chameleon-like models. Based on this assumption, some cosmological parameters, including the Hubble, deceleration, and coincidence parameters, in such a mechanism are analyzed. It is realized that, to estimate the free parameters of a theoretical model, by regarding the systematic errors it is better that the whole of the above observational data sets would be considered. In fact, if one considers SNeIa, CMB, and BAO, but disregards OHD, it maybe leads to different results. Also, to get a better overlap between the contours with the constraint χ{sub m}{sup 2} ≤ 1, the χ{sub T}{sup 2} function could be re-weighted. The relative probability functions are plotted for marginalized likelihood L(Ω{sub m0}, ω{sub 1}, β) according to the two dimensional confidence levels 68.3, 90, and 95.4%. Meanwhile, the value of the free parameters which maximize the marginalized likelihoods using the above confidence levels are obtained. In addition, based on these calculations the minimum value of χ{sup 2} based on the free parameters of the ansatz for the effective dark energy equation of state is achieved. (orig.)

  20. The X-ray/radio and UV luminosity expected from the symbiotic systems as the progenitor of SNe Ia

    CERN Document Server

    Meng, Xiangcun

    2016-01-01

    We carried out a series of binary stellar evolution calculations, in which the effect of tidally enhanced wind on the evolution of WD + RG systems is incorporated. The WDs increase their mass to the Chandrasekhar mass limit, and then explode as SNe Ia. Based on the binary evolution results, we estimated the X-ray/radio (the excess UV) luminosity from the interactions between supernova ejecta and the CSM (the secondary) via some published standard models. We found that the X-ray flux may be high enough to be detected for a nearby SN Ia from a symbiotic system, while the radio flux is more likely to de detected when the companion is an asymptotic giant branch (AGB) star, and for a first giant branch (FGB) companion, the radio flux is generally lower than the detection limit. For two well observed SNe Ia, 2011fe and 2014J, almost all symbiotic systems are excluded by X-ray observations, but WD + FGB systems may not be ruled out by radio observations. The excess UV luminosity resulting from the collision of super...

  1. Auricular-Plaster Therapy for Treatment of IBS

    Institute of Scientific and Technical Information of China (English)

    敖学艳; 王宁

    2004-01-01

    @@ Irritable bowel syndrome (IBS), a disease of the digestive system related to mental factors, is clinically characterized by diarrhea (or alternation of diarrhea and constipation) and abdominal pain. In recent years, the authors have used auricular-plaster therapy plus pressing on the back-shu points to treat IBS, and obtained good therapeutic results.

  2. How Accessible Is IB Schooling? Evidence from Australia

    Science.gov (United States)

    Dickson, Anisah; Perry, Laura B.; Ledger, Susan

    2017-01-01

    This study examines access to International Baccalaureate schools in Australia. It is important to examine whether, as a highly regarded form of rigorous academic education, IB programmes are available to a wide range of students. We examine the location of schools in Australia that offer one or more of the IB Primary Years Programme, Middle Years…

  3. Intestinal microbiota and diet in IBS: causes, consequences, or epiphenomena?

    Science.gov (United States)

    Rajilić-Stojanović, Mirjana; Jonkers, Daisy M; Salonen, Anne; Hanevik, Kurt; Raes, Jeroen; Jalanka, Jonna; de Vos, Willem M; Manichanh, Chaysavanh; Golic, Natasa; Enck, Paul; Philippou, Elena; Iraqi, Fuad A; Clarke, Gerard; Spiller, Robin C; Penders, John

    2015-02-01

    Irritable bowel syndrome (IBS) is a heterogeneous functional disorder with a multifactorial etiology that involves the interplay of both host and environmental factors. Among environmental factors relevant for IBS etiology, the diet stands out given that the majority of IBS patients report their symptoms to be triggered by meals or specific foods. The diet provides substrates for microbial fermentation, and, as the composition of the intestinal microbiota is disturbed in IBS patients, the link between diet, microbiota composition, and microbial fermentation products might have an essential role in IBS etiology. In this review, we summarize current evidence regarding the impact of diet and the intestinal microbiota on IBS symptoms, as well as the reported interactions between diet and the microbiota composition. On the basis of the existing data, we suggest pathways (mechanisms) by which diet components, via the microbial fermentation, could trigger IBS symptoms. Finally, this review provides recommendations for future studies that would enable elucidation of the role of diet and microbiota and how these factors may be (inter)related in the pathophysiology of IBS.

  4. Design of a LOW Cost IC Tester

    Directory of Open Access Journals (Sweden)

    Liakot Ali

    2005-01-01

    Full Text Available Low cost Integrated Circuit (IC testing is now a burning issue in semiconductor technology. Conventional IC tester, Automatic Test Equipment (ATE, cannot cope with the today’s continuously increasing complexities in IC technology. Deterministic algorithm, which is an idea of 1960’s, is adopted in the ATE. Recently pseudo-random testing approach of IC testing has been emerged as an economically viable alternative to the expensive deterministic testing approach. This study introduces the design of a System-on-a-chip (Soc implementing pseudo-random test technique for low cost IC testing with reliable performance. It is capable of testing combinational circuits as well as sequential circuits with scan-port facilities efficiently. It can also be used for testing Printed Circuit Board (PCB interconnection faults.

  5. 双星图的IC-指数%The IC-index of Double-stars

    Institute of Scientific and Technical Information of China (English)

    陈剑峰; 杨大庆

    2013-01-01

    已经知道双星图至多有两种极大IC-着色,并且其中一种情况下的IC-指数已经确定.在此基础上,研究了双星图的的另一种极大IC-着色,得到了在这种情况下的IC-指数.从而得到了双星图的所有极大IC-着色,且双星图的IC-指数为:M(DS(m,n))=(2m-1+1)(2n-1+1),其中2≤m≤n.%We known about the graph of double-stars contains two maximal IC-coloring at most,and one case of the IC-index have been determined.Based on this,this paper studied the another great IC-coloring of the graph of double-stars,and obtained in the circumstances of IC-index.So get the the graph of double-stars maximal IC-coloring,and the graph of double-stars IC-index as follow:M(DS(m,n)) =(2m-1 + 1)(2n-1 + 1),2 ≤ m ≤ n.

  6. Paternal uniparental isodisomy of the entire chromosome 20 as a molecular cause of pseudohypoparathyroidism type Ib (PHP-Ib).

    Science.gov (United States)

    Bastepe, Murat; Altug-Teber, Ozge; Agarwal, Chhavi; Oberfield, Sharon E; Bonin, Michael; Jüppner, Harald

    2011-03-01

    Pseudohypoparathyoridism type Ib (PHP-Ib) typically defines the presence of end-organ resistance to parathyroid hormone in the absence of Albright's hereditary osteodystrophy. Patients affected by this disorder present with imprinting defects in the complex GNAS locus. Microdeletions within STX16 or GNAS have been identified in familial cases with PHP-Ib, but the molecular cause of the GNAS imprinting defects in sporadic PHP-Ib cases remains poorly defined. We now report a case with sporadic PHP-Ib for whom a SNPlex analysis revealed loss of the maternal GNAS allele. Further analysis of the entire genome with a 100K SNP chip identified a paternal uniparental isodisomy affecting the entire chromosome 20 without evidence for another chromosomal abnormality. Our findings explain the observed GNAS methylation changes and the patient's hormone resistance, and furthermore suggest that chromosome 20 harbors, besides GNAS, no additional imprinted region that contributes to the clinical and laboratory phenotype.

  7. IC-coloring and IC-index of Octopus Graphs%章鱼图的IC-着色和IC-指数

    Institute of Scientific and Technical Information of China (English)

    杨杨; 王力工

    2014-01-01

    章鱼图H(Cm,n)是指由圈Cm的一个顶点与星图STn=K1,n的中心重迭得到的图,研究了章鱼图H(Cm,n)的IC-着色问题,通过分类讨论的方法,分别得到了当m=3,4,5,n≥1时章鱼图H(Cm,n)的极大IC-着色和它们相应的IC-指数,并提出章鱼图H(Cm,n)一个上界猜想。%The octopus graph H(Cm, n) is formed by identifying a vertex of the cycle Cm and the center of a star STn=K1,n . In this paper, the problem of IC-colorings on the octopus graph is studied. When m=3,4,5,n≥1 , IC-indices and maximal IC-colorings of the octopus graph H(Cm, n) are obtained respectively. A conjecture for the up-per bound of the IC-index of the octopus graph is proposed.

  8. SPROC: A multiple-processor DSP IC

    Science.gov (United States)

    Davis, R.

    1991-01-01

    A large, single-chip, multiple-processor, digital signal processing (DSP) integrated circuit (IC) fabricated in HP-Cmos34 is presented. The innovative architecture is best suited for analog and real-time systems characterized by both parallel signal data flows and concurrent logic processing. The IC is supported by a powerful development system that transforms graphical signal flow graphs into production-ready systems in minutes. Automatic compiler partitioning of tasks among four on-chip processors gives the IC the signal processing power of several conventional DSP chips.

  9. A physically motivated classification of stripped-envelope supernovae

    Science.gov (United States)

    Prentice, S. J.; Mazzali, P. A.

    2017-08-01

    The classification of stripped-envelope supernovae (SE-SNe) is revisited using modern data sets. Spectra are analysed using an empirical method to 'blindly' categorize SNe according to spectral feature strength and appearance. This method makes a clear distinction between SNe that are He-rich (IIb/Ib) and He-poor (Ic), and further analysis is performed on each subgroup. For He-rich SNe, the presence of H becomes the focus. The strength, velocity, and ratio between absorption and emission of H α are measured, along with additional analysis of He I lines, in order to categorize the SNe. The He-poor SNe are ordered according to the number of absorption features N present in the spectra, which is a measure of the degree of line blending. The kinetic energy per unit mass Ek/Mej is strongly affected by mass at high velocity, and such situations principally occur when the outer density profile of the ejecta is shallow, leading to the blending of lines. Using the results, the existing SE-SN taxonomic scheme is adapted. He-rich SNe are split into four groups, IIb, IIb(I), Ib(II) and Ib, which represent H-rich to H-poor SNe. The SNe Ic category of broad-lined Ic (Ic-BL) is abandoned in favour of quantifying the line blending via 〈N〉 before peak. To better reflect the physical parameters of the explosions, the velocity of Si Uii at peak and the half-luminosity decay time t+1/2 are included to give SNe Ic a designation of Ic-〈N〉(vp, SiII/t+1/2).

  10. Flow cytometry combined with viSNE for the analysis of microbial biofilms and detection of microplastics

    Science.gov (United States)

    Sgier, Linn; Freimann, Remo; Zupanic, Anze; Kroll, Alexandra

    2016-01-01

    Biofilms serve essential ecosystem functions and are used in different technical applications. Studies from stream ecology and waste-water treatment have shown that biofilm functionality depends to a great extent on community structure. Here we present a fast and easy-to-use method for individual cell-based analysis of stream biofilms, based on stain-free flow cytometry and visualization of the high-dimensional data by viSNE. The method allows the combined assessment of community structure, decay of phototrophic organisms and presence of abiotic particles. In laboratory experiments, it allows quantification of cellular decay and detection of survival of larger cells after temperature stress, while in the field it enables detection of community structure changes that correlate with known environmental drivers (flow conditions, dissolved organic carbon, calcium) and detection of microplastic contamination. The method can potentially be applied to other biofilm types, for example, for inferring community structure for environmental and industrial research and monitoring. PMID:27188265

  11. Integrated Baseline System (IBS) Version 2.0: Utilities Guide

    Energy Technology Data Exchange (ETDEWEB)

    Burford, M.J.; Downing, T.R.; Williams, J.R. [Pacific Northwest Lab., Richland, WA (United States); Bower, J.C. [Bower Software Services, Kennewick, WA (United States)

    1994-03-01

    The Integrated Baseline System (IBS) is an emergency management planning and analysis tool being developed under the direction of the US Army Nuclear and Chemical Agency. This Utilities Guide explains how you can use the IBS utility programs to manage and manipulate various kinds of IBS data. These programs include utilities for creating, editing, and displaying maps and other data that are referenced to geographic location. The intended audience for this document are chiefly data managers but also system managers and some emergency management planners and analysts.

  12. Key factors of successful JIT integration with IBS - An overview

    Science.gov (United States)

    Asri, Mohammad Azwanie Naim Mohammad; Nawi, Mohd Nasrun Mohd; Nadarajan, Santhirasegaran

    2016-08-01

    The Just-In-Time (JIT) philosophy has been used for many decades to increase productivity through waste elimination process. The purpose of this paper is to contribute to the knowledge by addressing the transportation and material delivery activities in Industrialized Building System (IBS) and integrating JIT to improve the performance of those activities. The literature review has been conducted through relevant database. It was found that there is a need for more holistic approach to be adopted to integrate JIT in IBS project. This paper discusses the key success factors for effective integration between JIT and IBS in the context of transportation and material delivery activities.

  13. Integrated Baseline System (IBS) Version 1.03: Utilities guide

    Energy Technology Data Exchange (ETDEWEB)

    Burford, M.J.; Downing, T.R.; Pottier, M.C.; Schrank, E.E.; Williams, J.R.

    1993-01-01

    The Integrated Baseline System (IBS) is an emergency management planning and analysis tool that was developed under the direction of the Federal Emergency Management Agency (FEMA). This Utilities Guide explains how to operate utility programs that are supplied as a part of the IBS. These utility programs are chiefly for managing and manipulating various kinds of IBS data and system administration files. Many of the utilities are for creating, editing, converting, or displaying map data and other data that are related to geographic location.

  14. IBS simulation with different RF configurations in RHIC

    Energy Technology Data Exchange (ETDEWEB)

    Liu, C. [Brookhaven National Lab. (BNL), Upton, NY (United States); Fedotov, A. [Brookhaven National Lab. (BNL), Upton, NY (United States); Minty, M. [Brookhaven National Lab. (BNL), Upton, NY (United States); Ptitsyn, V. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2016-11-07

    It is a crucial task to understand the beam emittance growth during RHIC cycle and the underlying causes. One would benefit not just for the current operation of RHIC, also for the design of eRHIC. This report focuses on the Intra-Beam Scattering (IBS) contribution to the emittance growth of the proton beam with two different configurations of RF system. The answers to these questions will be given in the end of the report; can IBS explain the emittance growth all alone? What’s the difference of IBS growth rates for different RF configurations?

  15. RADIATION HARDENED ANALOG IC FOR SENSOR

    Directory of Open Access Journals (Sweden)

    O. V. Dvornikov

    2011-01-01

    Full Text Available Problems of specialized analog integrated circuit design for sensor equipments are considered. It is offered to produce of radiation hardened analog IC on structured chips for economic efficiency at small production volume. The approach to analog IC design is described, including recommendations for choice of: types and quantities of structured chip analogue components; active and passive components; schematic decisions of analogue components with programmed parameters and small sensitivity to radiation. 

  16. Information Commons for Rice (IC4R).

    Science.gov (United States)

    Hao, Lili; Zhang, Huiyong; Zhang, Zhang; Hu, Songnian; Xue, Yu

    2016-01-04

    Rice is the most important staple food for a large part of the world's human population and also a key model organism for plant research. Here, we present Information Commons for Rice (IC4R; http://ic4r.org), a rice knowledgebase featuring adoption of an extensible and sustainable architecture that integrates multiple omics data through community-contributed modules. Each module is developed and maintained by different committed groups, deals with data collection, processing and visualization, and delivers data on-demand via web services. In the current version, IC4R incorporates a variety of rice data through multiple committed modules, including genome-wide expression profiles derived entirely from RNA-Seq data, resequencing-based genomic variations obtained from re-sequencing data of thousands of rice varieties, plant homologous genes covering multiple diverse plant species, post-translational modifications, rice-related literatures and gene annotations contributed by the rice research community. Unlike extant related databases, IC4R is designed for scalability and sustainability and thus also features collaborative integration of rice data and low costs for database update and maintenance. Future directions of IC4R include incorporation of other omics data and association of multiple omics data with agronomically important traits, dedicating to build IC4R into a valuable knowledgebase for both basic and translational researches in rice. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

  17. e-MERLIN and VLBI observations of the luminous infrared galaxy IC883: a nuclear starburst and an AGN candidate revealed

    CERN Document Server

    Romero-Canizales, C; Alberdi, A; Argo, M K; Beswick, R J; Kankare, E; Batejat, F; Efstathiou, A; Mattila, S; Conway, J E; Garrington, S T; Muxlow, T W B; Ryder, S D; Vaisanen, P

    2012-01-01

    The high star formation rates of luminous infrared galaxies (LIRGs) make them ideal places for core-collapse supernova (CCSN) searches. At radio frequencies, free from dust extinction, it is possible to detect compact components within the innermost LIRG nuclear regions, such as SNe and SN remnants, as well as AGN buried deep in the LIRG nuclei. We studied the LIRG IC883 aiming at: (i) investigating its (circum-)nuclear regions using the e-EVN at 5GHz, and e-MERLIN at 6.9GHz, complemented by archival VLBI data; (ii) detecting at radio frequencies the two recently reported circumnuclear SNe 2010cu and 2011hi, which were discovered by near-IR (NIR) adaptive optics observations of IC883; and (iii) further investigating the nature of SN2011hi at NIR by means of observations with Gemini-North. The circumnuclear regions traced by e-MERLIN at 6.9GHz have an extension of ~1kpc, and show a striking double-sided structure, which very likely corresponds to a warped rotating ring, in agreement with previous studies. Our ...

  18. Endocannabinoid and cannabinoid-like fatty acid amide levels correlate with pain-related symptoms in patients with IBS-D and IBS-C: a pilot study.

    Directory of Open Access Journals (Sweden)

    Jakub Fichna

    Full Text Available AIMS: Irritable bowel syndrome (IBS is a functional gastrointestinal (GI disorder, associated with alterations of bowel function, abdominal pain and other symptoms related to the GI tract. Recently the endogenous cannabinoid system (ECS was shown to be involved in the physiological and pathophysiological control of the GI function. The aim of this pilot study was to investigate whether IBS defining symptoms correlate with changes in endocannabinoids or cannabinoid like fatty acid levels in IBS patients. METHODS: AEA, 2-AG, OEA and PEA plasma levels were determined in diarrhoea-predominant (IBS-D and constipation-predominant (IBS-C patients and were compared to healthy subjects, following the establishment of correlations between biolipid contents and disease symptoms. FAAH mRNA levels were evaluated in colonic biopsies from IBS-D and IBS-C patients and matched controls. RESULTS: Patients with IBS-D had higher levels of 2AG and lower levels of OEA and PEA. In contrast, patients with IBS-C had higher levels of OEA. Multivariate analysis found that lower PEA levels are associated with cramping abdominal pain. FAAH mRNA levels were lower in patients with IBS-C. CONCLUSION: IBS subtypes and their symptoms show distinct alterations of endocannabinoid and endocannabinoid-like fatty acid levels. These changes may partially result from reduced FAAH expression. The here reported changes support the notion that the ECS is involved in the pathophysiology of IBS and the development of IBS symptoms.

  19. Alexa Fluor 546-ArIB[V11L;V16A] is a potent ligand for selectively labeling alpha 7 nicotinic acetylcholine receptors.

    Science.gov (United States)

    Hone, Arik J; Whiteaker, Paul; Mohn, Jesse L; Jacob, Michele H; McIntosh, J Michael

    2010-08-01

    The alpha7* (*denotes the possible presence of additional subunits) nicotinic acetylcholine receptor (nAChR) subtype is widely expressed in the vertebrate nervous system and implicated in neuropsychiatric disorders that compromise thought and cognition. In this report, we demonstrate that the recently developed fluorescent ligand Cy3-ArIB[V11L;V16A] labels alpha7 nAChRs in cultured hippocampal neurons. However, photobleaching of this ligand during long image acquisition times prompted us to develop a new derivative. In photostability studies, this new ligand, Alexa Fluor 546-ArIB[V11L;V16A], was significantly more resistant to bleaching than the Cy3 derivative. The classic alpha7 ligand alpha-bungarotoxin binds to alpha1* and alpha9* nAChRs. In contrast, Alexa Fluor 546-ArIB[V11L;V16A] potently (IC(50) 1.8 nM) and selectively blocked alpha7 nAChRs but not alpha1* or alpha9* nAChRs expressed in Xenopus oocytes. Selectivity was further confirmed by competition binding studies of native nAChRs in rat brain membranes. The fluorescence properties of Alexa Fluor 546-ArIB[V11L;V16A] were assessed using human embryonic kidney-293 cells stably transfected with nAChRs; labeling was observed on cells expressing alpha7 but not cells expressing alpha3beta2, alpha3beta4, or alpha4beta2 nAChRs. Further imaging studies demonstrate that Alexa Fluor 546-ArIB[V11L;V16A] labels hippocampal neurons from wild-type mice but not from nAChR alpha7 subunit-null mice. Thus, Alexa Fluor 546-ArIB[V11L;V16A] represents a potent and selective ligand for imaging alpha7 nAChRs.

  20. Association between Blastocystis hominis and irritable bowel syndrome(IBS

    Directory of Open Access Journals (Sweden)

    Azadeh Darabian

    2016-09-01

    Full Text Available This study was designed to examine the association between Blastocystis hominis and irritable bowel syndrome(IBS. In this case-control study that conducted in Mashhad, Iran in 2014-2015, one hundred IBS cases and one hundred matched (age and sex healthy people were participated. Direct stool examination, formalin-ether concentration technique and trichrome staining were done. The data were analyzed by SPSS20 with Fisher's exact test and T-test. One hundred IBS patients (31 males and 69 females had a mean age of 29.5 (±7.4 years. B. hominis were positive in 26% of IBS participants, and 9% in control group (P-value=0.002,Risk Estimate=3.5. Giardia lamblia were positive in 6% of IBS participants, and in none of control participants (P-value=0.01. Trichrome staining for detection of B. hominis was more sensitive than direct examination and formalin-ether concentration technique (P-value <0/001. B. hominis was more frequent in patients with irritable bowel syndrome. For detection of B. hominis, trichrome staining was more sensitive than other methods. Authors suggest that in patients with IBS, stool should be examined with different methods for three times to obtain a more reliable diagnosis.

  1. Core-collapse Supernovae from the Palomar Transient Factory: Indications for a Different Population in Dwarf Galaxies

    Science.gov (United States)

    Arcavi, Iair; Gal-Yam, Avishay; Kasliwal, Mansi M.; Quimby, Robert M.; Ofek, Eran O.; Kulkarni, Shrinivas R.; Nugent, Peter E.; Cenko, S. Bradley; Bloom, Joshua S.; Sullivan, Mark; Howell, D. Andrew; Poznanski, Dovi; Filippenko, Alexei V.; Law, Nicholas; Hook, Isobel; Jönsson, Jakob; Blake, Sarah; Cooke, Jeff; Dekany, Richard; Rahmer, Gustavo; Hale, David; Smith, Roger; Zolkower, Jeff; Velur, Viswa; Walters, Richard; Henning, John; Bui, Kahnh; McKenna, Dan; Jacobsen, Janet

    2010-09-01

    We use the first compilation of 72 core-collapse supernovae (SNe) from the Palomar Transient Factory (PTF) to study their observed subtype distribution in dwarf galaxies compared to giant galaxies. Our sample is the largest single-survey, untargeted, spectroscopically classified, homogeneous collection of core-collapse events ever assembled, spanning a wide host-galaxy luminosity range (down to Mr ≈ -14 mag) and including a substantial fraction (>20%) of dwarf (Mr >= -18 mag) hosts. We find more core-collapse SNe in dwarf galaxies than expected and several interesting trends emerge. We use detailed subclassifications of stripped-envelope core-collapse SNe and find that all Type I core-collapse events occurring in dwarf galaxies are either SNe Ib or broad-lined SNe Ic (SNe Ic-BL), while "normal" SNe Ic dominate in giant galaxies. We also see a significant excess of SNe IIb in dwarf hosts. We hypothesize that in lower metallicity hosts, metallicity-driven mass loss is reduced, allowing massive stars that would have appeared as "normal" SNe Ic in metal-rich galaxies to retain some He and H, exploding as Ib/IIb events. At the same time, another mechanism allows some stars to undergo extensive stripping and explode as SNe Ic-BL (and presumably also as long-duration gamma-ray bursts). Our results are still limited by small-number statistics, and our measurements of the observed N(Ib/c)/N(II) number ratio in dwarf and giant hosts (0.25+0.3 -0.15 and 0.23+0.11 -0.08, respectively; 1σ uncertainties) are consistent with previous studies and theoretical predictions. As additional PTF data accumulate, more robust statistical analyses will be possible, allowing the evolution of massive stars to be probed via the dwarf-galaxy SN population.

  2. Determination of the Hubble constant, the intrinsic scatter of luminosities of Type Ia SNe, and evidence for non-standard dust in other galaxies

    CERN Document Server

    Wang, X; Pain, R; Wang, L; Zhou, X; Li, Zongwei; Pain, Reynald; Wang, Lifan; Wang, Xiaofeng; Zhou, Xu

    2006-01-01

    A sample of 109 type Ia supernovae (SNe Ia) with recession velocity < 30,000 km s^{-1}, is compiled from published SNe Ia light curves to explore the expansion rate of the local Universe. Based on the color parameter \\Delta C_{12}, we found that the average absorption to reddening ratio for SN Ia host galaxies to be R_{UBVI} = 4.37+/-0.25, 3.33+/-0.11, 2.30+/-0.11, 1.18+/-0.11, which are systematically lower than the standard values in the Milky Way. We investigated the correlations of the intrinsic luminosity with light curve decline rate, color index, and supernova environmental parameters. In particular, we found SNe Ia in E/S0 galaxies to be brighter close to the central region than those in the outer region, which may suggest a possible metallicity effect on SN luminosity. The dependence of SN luminosity on galactic environment disappears after corrections for the extinction and \\Delta C_{12}. The Hubble diagrams constructed using 73 Hubble flow SNe Ia yield a 1-$\\sigma$ scatter of <0.12 mag in BVI...

  3. A mildly relativistic radio jet from the otherwise normal type Ic supernova 2007gr.

    Science.gov (United States)

    Paragi, Z; Taylor, G B; Kouveliotou, C; Granot, J; Ramirez-Ruiz, E; Bietenholz, M; van der Horst, A J; Pidopryhora, Y; van Langevelde, H J; Garrett, M A; Szomoru, A; Argo, M K; Bourke, S; Paczyński, B

    2010-01-28

    The class of type Ic supernovae have drawn increasing attention since 1998 owing to their sparse association (only four so far) with long duration gamma-ray bursts (GRBs). Although both phenomena originate from the core collapse of a massive star, supernovae emit mostly at optical wavelengths, whereas GRBs emit mostly in soft gamma-rays or hard X-rays. Though the GRB central engine generates ultra-relativistic jets, which beam the early emission into a narrow cone, no relativistic outflows have hitherto been found in type Ib/c supernovae explosions, despite theoretical expectations and searches. Here we report radio (interferometric) observations that reveal a mildly relativistic expansion in a nearby type Ic supernova, SN 2007gr. Using two observational epochs 60 days apart, we detect expansion of the source and establish a conservative lower limit for the average apparent expansion velocity of 0.6c. Independently, a second mildly relativistic supernova has been reported. Contrary to the radio data, optical observations of SN 2007gr indicate a typical type Ic supernova with ejecta velocities approximately 6,000 km s(-1), much lower than in GRB-associated supernovae. We conclude that in SN 2007gr a small fraction of the ejecta produced a low-energy mildly relativistic bipolar radio jet, while the bulk of the ejecta were slower and, as shown by optical spectropolarimetry, mildly aspherical.

  4. The Titan Haze Simulation experiment on COSmIC: Probing Titan's atmospheric chemistry at low temperature

    Science.gov (United States)

    Sciamma-O'Brien, Ella; Ricketts, Claire L.; Salama, Farid

    2014-11-01

    The aim of the Titan Haze Simulation (THS) experiment is to contribute to a better understanding of aerosol formation in Titan's atmosphere through the study of the chemical formation pathways that link the simpler gas phase molecules resulting from the first steps of the N2-CH4 chemistry, to the more complex gas phase precursors of aerosols; and more specifically, to investigate the role of polycyclic aromatic hydrocarbons (PAHs) and nitrogenated polycyclic aromatic hydrocarbons (PANHs), among other hydrocarbons, in this process. In the THS experiment developed at the NASA Ames Cosmic simulation facility (COSmIC), Titan's atmospheric chemistry is simulated by a pulsed plasma jet expansion at temperature conditions (∼150 K) close to those found in Titan's atmosphere in regions where aerosols are formed. In addition, because of the very short residence time of the gas in the plasma discharge, only the initial steps of the chemistry occur, making the COSmIC/THS a unique tool to study the first and intermediate (when adding heavier precursors to the initial N2-CH4 mixture) steps of Titan's atmospheric chemistry at low temperature as shown in the study presented here. We further illustrate the potential of COSmIC/THS for the simulation of Titan's atmospheric chemistry by presenting very promising results from a preliminary comparison of the laboratory data to data from the Cassini Plasma Spectrometer-Ion Beam Spectrometer (CAPS-IBS) instrument.

  5. Cosmic Assembly Near-IR Deep Extragalactic Legacy Survey -- GOODS-South Field, Non-SNe-Searched Visits

    Science.gov (United States)

    Faber, Sandra

    2011-10-01

    The Cosmic Assembly Near-IR Deep Extragalactic Legacy Survey {CANDELS}is designed to document the ?rst third of galactic evolution from z =8 to 1.5 via deep imaging of more than 250,000 galaxies with WFC3/IRand ACS. It will also find the first Type Ia SNe beyond z > 1.5 andestablish their accuracy as standard candles for cosmology. Fivepremier multi-wavelength sky regions selected from the SpitzerExtragalactic Deep Survey {SEDS} provide complementary IRAC imagingdata down to 26.5 AB mag, a unique resource for stellar masses at allredshifts. The use of ?ve widely separated ?elds mitigates cosmicvariance and yields statistically robust and complete samples ofgalaxies down to 10^9 solar masses out to z 8.The program merges two originally separate MCT proposals. The Faberprogram incorporates a ?Wide? imaging survey in three separate fieldsto 2 orbit depth over 0.2 sq. degrees, plus a ?Deep? imaging surveyto 12 orbit depth in the two GOODS regions over 0.04 sq. degrees.When combined with ultra-deep imaging from the Hubble Ultradeep Fieldprogram {GO 11563}, the result is a three-tiered strategy that ef?cientlysamples both bright/rare and faint/common extragalactic objects. TheFerguson program adds an extensive high-redshift Type Ia SNe search,plus ultraviolet "daytime" UVIS exposures in GOODS-N to exploit theCVZ opportunity in that field.This program, GO 12064, is part of the Wide mosaic survey, which has thefollowing field centers and sizes: Field ID RA{2000} Dec{2000} WFC3 Dim. PA on sky UDS 02 17 38 -05 12 02 4x11 270 COSMOS 10 00 31 +02 24 00 4x11 180 EGS 14 19 31 +52 54 10 3x15 41 Science highlights from the Wide program: * Underlying structural properties of galaxies as revealed by WFC3-IR images sensitive to older stars {beyond the 4000-A break} and less affected by dust than ACS. A key redshift is z 2, where star-formation peaks, QSOs are most abundant, and where restframe B-band is still accessible to WFC3. Sample questions include: - Structure in young vs. old

  6. Motility response to colonic distention is increased in postinfectious irritable bowel syndrome (PI-IBS).

    Science.gov (United States)

    Kanazawa, M; Palsson, O S; van Tilburg, M A L; Gangarosa, L M; Fukudo, S; Whitehead, W E

    2014-05-01

    Acute intestinal infection leads to persistent intestinal smooth muscle hypercontractility and pain hypersensitivity after resolution of the infection in animal models. We investigated whether postinfectious irritable bowel syndrome (PI-IBS) is associated with abnormalities in phasic contractions of the colon, smooth muscle tone, and pain sensitivity compared to non-PI-IBS (NI-IBS) or healthy controls (HC). Two hundred and eighteen Rome III-positive IBS patients and 43 HC participated. IBS patients were designated PI-IBS, if their IBS symptoms began following an episode of gastroenteritis characterized by two or more of: fever, vomiting, or diarrhea. Pain threshold to phasic distentions of the descending colon was assessed using a barostat. Colonic motility was assessed with the barostat bag minimally inflated to the individual operating pressure (IOP), at 20 mmHg above the IOP, and following a test meal. IBS symptom severity and psychological symptoms were assessed by the IBS Severity Scale (IBS-SS) and the Brief Symptom Inventory-18 (BSI-18). Twenty two (10.1%) met criteria for PI-IBS. Both IBS and HC groups showed a significant increase in motility index during intraluminal distention and following meals. The magnitude of the response to distention above (orad to) the balloon was significantly greater in PI-IBS compared with NI-IBS (p colonic hypercontractility than NI-IBS. We speculate that sustained mild mucosal inflammation may cause this colonic irritability. © 2014 John Wiley & Sons Ltd.

  7. The Selection of the Phone Charging IC

    Institute of Scientific and Technical Information of China (English)

    Jian ming Lei

    2013-01-01

    An expensive digital IC is used in old battery only charger (BOC) and this IC needs separate software. For simplify the design and reduce the cost, we find the existing analogy charging ICs and select the most popular four from them, including Mitsumi, Freescale, TI and Analogic Tech, we make a detailed comparison and select the best one, based on this IC’s feature and our requirements, A detailed design evaluation is presented, including the design of the input over voltage protection (OVP), output OVP and over temperature protection (OTP), the WCA (Worse Case Analysis) of this OTP. After the improvement, this new BOC has lower cost, simpler topology, more efficient power consumption.

  8. Challenges in IC design for hearing aids

    DEFF Research Database (Denmark)

    Jørgensen, Ivan Harald Holger

    2012-01-01

    Designing modern hearing aids is a formidable challenge. The size of hearing aids is constantly decreasing, making them virtually invisible today. Still, as in all other modern electronics, more and more features are added to these devices driven by the development in modern IC technology....... The demands for performance and features at very low supply voltage and power consumption constantly prove a challenge to the physical design of hearing aids and not at least the design of the ICs for these. As a result of this all large hearing aid manufacturers use fully customized ASICs in their products....... The size of the amplifier is critical for the size of the final hearing aid and a study of the size of these for different manufactures will be presented. Designing the ICs for hearing aids poses many challenges and is a constant compromise between size, power consumption and performance of the individual...

  9. Challenges in IC design for hearing aids

    DEFF Research Database (Denmark)

    Jørgensen, Ivan Harald Holger

    2012-01-01

    Designing modern hearing aids is a formidable challenge. The size of hearing aids is constantly decreasing, making them virtually invisible today. Still, as in all other modern electronics, more and more features are added to these devices driven by the development in modern IC technology....... The demands for performance and features at very low supply voltage and power consumption constantly prove a challenge to the physical design of hearing aids and not at least the design of the ICs for these. As a result of this all large hearing aid manufacturers use fully customized ASICs in their products...

  10. Mismatch and noise in modern IC processes

    CERN Document Server

    Marshall, Andrew

    2009-01-01

    Component variability, mismatch, and various noise effects are major contributors to design limitations in most modern IC processes. Mismatch and Noise in Modern IC Processes examines these related effects and how they affect the building block circuits of modern integrated circuits, from the perspective of a circuit designer.Variability usually refers to a large scale variation that can occur on a wafer to wafer and lot to lot basis, and over long distances on a wafer. This phenomenon is well understood and the effects of variability are included in most integrated circuit design with the use

  11. Differences between IC Analysis and TG Approach

    Institute of Scientific and Technical Information of China (English)

    张美玲

    2014-01-01

    Structuralism and generative approach are two representative syntax theories, which study language from different per-spectives. They employ different methodologies i.e. Immediate constituent (IC) Analysis and transformational-generative (TG) approach to make syntactical analysis. In this paper, these two methods will be applied to analyze some sentences for further dis-cussion and comparison. After analysis by examples, we find that both these two methods have their merits and inadequacies. To some extent, TG method can help IC analysis solve some problems. However, TG grammar is by no means complete and perfect. Improvements are needed to reach its ultimate goal of producing a universal grammar for all human languages.

  12. Abundances of Planetary Nebulae IC 418, IC 2165 and NGC 5882

    NARCIS (Netherlands)

    Pottasch, [No Value; Bernard-Salas, J; Beintema, DA; Feibelman, WA

    2004-01-01

    The ISO and IUE spectra of the elliptical nebulae NGC 5882, IC 418 and IC 2165 are presented. These spectra are combined with the spectra in the visual wavelength region to obtain a complete, extinction corrected, spectrum. The chemical composition of the nebulae is then calculated and compared to p

  13. Flexibility of Supply Chain in Industrialised Building System (IBS

    Directory of Open Access Journals (Sweden)

    Kassim U.

    2014-01-01

    Full Text Available It is irrefutable that the construction industry is in need of a highly technological construction method or system for the simple aim of giving it a push it deserves. In Malaysia this technologically enhanced method is known as the Indutrialised Building System (IBS. Concerted efforts have been made for the past decade by various responsible parties especially by the government. Therefore, the IBS ‘Road Map’ 2003–2010 was introduced and now continues with the IBS ‘road map’ 2011-2015. However, its performance is still at its infancy, which target is only at an initial stage. This study seeks to identify and analyse the factor of the IBS’ system’s supply chain flexibility as a factor on the success of the system itself. It has been a suspicion that there exists a condition and situation where the supply chain is too rigid and is not flexible in fulfilling the needs and demands of the IBS development in Malaysia. This inflexible situation has brought about a broad range of problems and has stood in the way of the development of the industrialised building system, despite it being introduced since 1964, or 49 years ago. Flexibility in the IBS supply chain is very important and is associated with other industries like transportation, manufacturing industry, and others. Up until now, we have yet to discover any special studies related to the flexibility in the IBS supply chain in this country. Responding to this challenge, this research is hoped to be able to provide sufficient feedback to the solution to the IBS supply chain flexibility issue. The researcher is confident that the poor system flow of supply chain has impeded the advancement of the Industrialised Building System that has long been open to debate.

  14. Abundance stratification in Type Ia supernovae - V. SN 1986G bridging the gap between normal and subluminous SNe Ia

    CERN Document Server

    Ashall, C; Pian, E; James, P A

    2016-01-01

    A detailed spectroscopic analysis of SN 1986G has been performed. SN 1986G `bridges the gap' between normal and sub luminous type Ia supernova (SNe Ia). The abundance tomography technique is used to determine the abundance distribution of the elements in the ejecta. SN 1986G was found to be a low energy Chandrasekhar mass explosion. Its kinetic energy was 70% of the standard W7 model (0.9x10$^{51}$erg). Oxygen dominates the ejecta from the outermost layers down to $\\sim$9000kms$^{-1}$ , intermediate mass elements (IME) dominate from $\\sim$ 9000kms$^{-1}$ to $\\sim$ 3500kms$^{-1}$ with Ni and Fe dominating the inner layers $<\\sim$ 3500kms$^{-1}$. The final masses of the main elements in the ejecta were found to be, O=0.33M, IME=0.69M, stable NSE=0.21M, $^{56}$Ni=0.14M. An upper limit of the carbon mass is set at C=0.02M. The spectra of SN1986G consist of almost exclusively singly ionised species. SN1986G can be thought of as a low luminosity extension of the main population of SN Ia, with a large deflagratio...

  15. Massive stars exploding in a He-rich circumstellar medium - IX. SN 2014av, and characterization of Type Ibn SNe

    CERN Document Server

    Pastorello, A; Ciabattari, F; Bersier, D; Mazzali, P A; Gao, X; Xu, Z; Zhang, J -J; Tokuoka, S; Benetti, S; Cappellaro, E; Elias-Rosa, N; Harutyunyan, A; Huang, F; Miluzio, M; Mo, J; Ochner, P; Tartaglia, L; Terreran, G; Tomasella, L; Turatto, M

    2015-01-01

    We present spectroscopic and photometric data of the Type Ibn supernova (SN) 2014av, discovered by the Xingming Observatory Sky Survey. A stringent pre-discovery detection limit indicates that the object was discovered soon after core-collapse. A prompt follow-up campaign arranged by amateur astronomers allows us to monitor the rising phase (lasting 10.6 days) and to accurately estimate the epoch of the maximum light, on 2014 April 23 (JD = 2456771.1 +- 1.2). The absolute magnitude of the SN at the maximum light is M(R) = -19.76 +- 0.16. The post-peak light curve shows an initial fast decline lasting about 3 weeks, and is followed by a slower decline in all bands until the end of the monitoring campaign. The spectra are initially characterized by a hot continuum. Later on, the temperature declines and a number of lines become prominent mostly in emission. In particular, later spectra are dominated by strong and narrow emission features of He I typical of Type Ibn supernovae (SNe), although there is clear evid...

  16. Embedded I&C for Extreme Environments

    Energy Technology Data Exchange (ETDEWEB)

    Kisner, Roger A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2016-04-01

    This project uses embedded instrumentation and control (I&C) technologies to demonstrate potential performance gains of nuclear power plant components in extreme environments. Extreme environments include high temperature, radiation, high pressure, high vibration, and high EMI conditions. For extreme environments, performance gains arise from moment-to-moment sensing of local variables and immediate application of local feedback control. Planning for embedding I&C during early system design phases contrasts with the traditional, serial design approach that incorporates minimal I&C after mechanical and electrical design is complete. The demonstration application involves the development and control of a novel, proof-of-concept motor/pump design. The motor and pump combination operate within the fluid environment, eliminating the need for rotating seals. Actively controlled magnetic bearings also replace failure-prone mechanical contact bearings that typically suspend rotating components. Such as design has the potential to significantly enhance the reliability and life of the pumping system and would not be possible without embedded I&C.

  17. Generating Analog IC Layouts with LAYGEN II

    CERN Document Server

    Martins, Ricardo M F; Horta, Nuno C G

    2013-01-01

    This book presents an innovative methodology for the automatic generation of analog integrated circuits (ICs) layout, based on template descriptions and on evolutionary computational techniques. A design automation tool, LAYGEN II, was implemented to validate the proposed approach giving special emphasis to reusability of expert design knowledge and to efficiency on retargeting operations.

  18. Mechanisms and efficacy of dietary FODMAP restriction in IBS.

    Science.gov (United States)

    Staudacher, Heidi M; Irving, Peter M; Lomer, Miranda C E; Whelan, Kevin

    2014-04-01

    IBS is a debilitating condition that markedly affects quality of life. The chronic nature, high prevalence and associated comorbidities contribute to the considerable economic burden of IBS. The pathophysiology of IBS is not completely understood and evidence to guide management is variable. Interest in dietary intervention continues to grow rapidly. Ileostomy and MRI studies have demonstrated that some fermentable carbohydrates increase ileal luminal water content and breath hydrogen testing studies have demonstrated that some carbohydrates also increase colonic hydrogen production. The effects of fermentable carbohydrates on gastrointestinal symptoms have also been well described in blinded, controlled trials. Dietary restriction of fermentable carbohydrates (popularly termed the 'low FODMAP diet') has received considerable attention. An emerging body of research now demonstrates the efficacy of fermentable carbohydrate restriction in IBS; however, limitations still exist with this approach owing to a limited number of randomized trials, in part due to the fundamental difficulty of placebo control in dietary trials. Evidence also indicates that the diet can influence the gut microbiota and nutrient intake. Fermentable carbohydrate restriction in people with IBS is promising, but the effects on gastrointestinal health require further investigation.

  19. TDR method for determine IC's parameters

    Science.gov (United States)

    Timoshenkov, V.; Rodionov, D.; Khlybov, A.

    2016-12-01

    Frequency domain simulation is a widely used approach for determine integrated circuits parameters. This approach can be found in most of software tools used in IC industry. Time domain simulation approach shows intensive usage last years due to some advantages. In particular it applicable for analysis of nonlinear and nonstationary systems where frequency domain is inapplicable. Resolution of time domain systems allow see heterogeneities on distance 1mm, determine it parameters and properties. Authors used approach based on detecting reflected signals from heterogeneities - time domain reflectometry (TDR). Field effect transistor technology scaling up to 30-60nm gate length and 10nm gate dielectric, heterojunction bi-polar transistors with 10-30nm base width allows fabricate digital IC's with 20GHz clock frequency and RF-IC's with tens GHz bandwidth. Such devices and operation speed suppose transit signal by use microwave lines. There are local heterogeneities can be found inside of the signal path due to connections between different parts of signal lines (stripe line-RF-connector pin, stripe line - IC package pin). These heterogeneities distort signals that cause bandwidth decrease for RF-devices. Time domain research methods of transmission and reflected signals give the opportunities to determine heterogeneities, it properties, parameters and built up equivalent circuits. Experimental results are provided and show possibility for inductance and capacitance measurement up to 25GHz. Measurements contains result of signal path research on IC and printed circuit board (PCB) used for 12GHz RF chips. Also dielectric constant versus frequency was measured up to 35GHz.

  20. FRAGMENTATION ISSUE IN MALAYSIAN INDUSTRIALISED BUILDING SYSTEM (IBS PROJECTS

    Directory of Open Access Journals (Sweden)

    MOHD NASRUN MOHD NAWI

    2014-02-01

    Full Text Available As a developing country, Malaysian is currently driving for implementing a new or modern construction method, the Industrialised Building System (IBS, as an alternative towards enhancing construction performance. Currently, most of the IBS project developments in Malaysia are still conducted by using the traditional construction process approach. This traditional construction process has been widely criticised for its fragmented approach to project delivery and its failure to form effective teams thus created a number of issues such as reworks, time delay, rising costs, lack of communication and coordination, and wastages. This paper through literature review aims to highlight this fragmentation issue and clarify how far it affects the process of IBS implementation. Suggestions on how an integrated approach in design and construction in order to minimise the fragmentation gaps will be concluded.

  1. Functional state of rat liver RNA polymerase IA and IB.

    Science.gov (United States)

    Zoncheddu, A; Accomando, R; Pertica, M; Orunesu, M

    1979-01-01

    Phosphocellulose chromatography has been employed to characterize RNA polymerase I present in two different functional states in rat liver cells. The actively transcribing enzyme solubilized from nuclei appears to belong both to the IA and IB classes, whereas the non-transcribing enzyme present in the cytoplasmic fraction has been found to belong only to the IA class. Indirect and direct evidence indicates, however, that in isolated nuclei only the IB form is to be regarded as the physiological form of the enzyme, the IA form arising as a procedural artefact during the extraction process. It may, therefore, be concluded that rat liver IA and IB RNA polymerase are to be strictly regarded as the non-transcribing and transcribing form of the enzyme, respectively.

  2. Optical Follow-Up Observations of PTF10qts, a Luminous Broad-Lined Type Ic Supernova Found by the Palomar Transient Factory

    Science.gov (United States)

    Walker, E. S.; Mazzali, P. A.; Pian, E.; Hurley, K.; Arcavi, I.; Cenko, S. B.; Gal-Yam, A.; Horesh, A.; Kasliwal, M.; Poznanski, D.; Silverman, J. M.; Barthelmy, S.

    2014-01-01

    We present optical photometry and spectroscopy of the broad-lined Type Ic supernova (SN Ic-BL) PTF10qts, which was discovered as part of the Palomar Transient Factory. The supernova was located in a dwarf galaxy of magnitude r = 21.1 at a redshift z = 0.0907.We find that the R-band light curve is a poor proxy for bolometric data and use photometric and spectroscopic data to construct and constrain the bolometric light curve. The derived bolometric magnitude at maximum light is Mbol = -18.51 +/- 0.2 mag, comparable to that of SN1998bw (Mbol = -18.7 mag) which was associated with a gamma-ray burst (GRB). PTF10qts is one of the most luminous SN Ic-BL observed without an accompanying GRB. We estimate the physical parameters of the explosion using data from our programme of follow-up observations, finding that it produced a larger mass of radioactive nickel compared to other SNeIc-BL with similar inferred ejecta masses and kinetic energies. The progenitor of the event was likely a approximately 20 solar mass star.

  3. X-ray and optical plateaus following the main bursts in GRBs and SNe Ⅱ-P: a hint about similar late injection behaviors?

    Institute of Scientific and Technical Information of China (English)

    Xiao-Hong Cui; Ren-Xin Xu

    2013-01-01

    We analyze the emission plateaus in the X-ray afterglow light curves of gamma-ray bursts (GRBs) and those in the optical light curves of type Ⅱ plateau supernovae (SNe Ⅱ-P) in order to study whether they have similar late energy injection behaviors.We show that correlations of bolometric energies (or luminosities) between the prompt explosions and the plateaus for the two phenomena are similar.The energy emitted by SNe Ⅱ-P are at the lower end of the range of possible energies for GRBs.The bolometric energies (or luminosities) in the prompt phase Eexpl (or Lexpl) and in the plateau phase Eplateau (or Lplateau) share relations of Eexpl ∝ E0.73±0.14plateau and Lexpl ∝ L~0.70plateau These results may indicate a similar late energy injection behavior that produces the observed plateaus in these two phenomena.

  4. Precision Ibéria : an opportunity on Facebook

    OpenAIRE

    Gomes, Cátia Daniela Nunes

    2012-01-01

    Precision Ibéria is a franchise company owned by 100% Portuguese investors. Characterized by being a Multibrand auto repair company, it has been present in Portugal for 10 years; Precision Ibéria is positioned as “one stop shop” providing all the mechanical services for all passenger car brands. From its beginning it has been focusing on consumer satisfaction, developing strat-egies that meet their needs. Unfortunately, the crisis that affects our country has reached the repair aftermarket se...

  5. Sne eller krig?

    DEFF Research Database (Denmark)

    Elling, Rasmus Christian

    2007-01-01

    Der er mange gode grunde til, at det tyrkiske militær rasler med sablen over for Irak og ikke alt handler om at nedkæmpe PKK. Men vil Tyrkiet risikere at starte sin egen Irak-krig i et af verdens mest utilgængelige steder? Udgivelsesdato: 8/11......Der er mange gode grunde til, at det tyrkiske militær rasler med sablen over for Irak og ikke alt handler om at nedkæmpe PKK. Men vil Tyrkiet risikere at starte sin egen Irak-krig i et af verdens mest utilgængelige steder? Udgivelsesdato: 8/11...

  6. A Trio of GRB-SNe: GRB 120729A, GRB 130215A / SN 2013ez and GRB 130831A / SN 2013fu

    CERN Document Server

    Cano, Z; Pozanenko, A; Butler, N; Thone, C C; Guidorzi, C; Kruhler, T; Gorosabel, J; Jakobsson, P; Leloudas, G; Malesani, D; Hjorth, J; Melandri, A; Mundell, C; Wiersema, K; D'Avanzo, P; Schulze, S; Gomboc, A; Johansson, A; Zheng, W; Kann, D A; Knust, F; Varela, K; Akerlof, C W; Bloom, J; Burkhonov, O; Cooke, E; de Diego, J A; Dhungana, G; Farina, C; Ferrante, F V; Flewelling, H A; Fox, O D; Fynbo, J; Gehrels, N; Georgiev, L; Gonzalez, J J; Greiner, J; Guver, T; Hartoog, O; Hatch, N; Jelinek, M; Kehoe, R; Klose, S; Klunko, E; Kopac, D; Kutyrev, A; Krugl, Y; Lee, W H; Levan, A; Linkov, V; Matkin, A; Minikulov, N; Molotov, I; Prochaska, J Xavier; Richer, M G; Roman-Zuniga, C G; Rumyantsev, V; Sanchez-Ramirez, R; Steele, I; Tanvir, N R; Volnova, A; Watson, A M; Xu, D; Yuan, F

    2014-01-01

    We present optical and near-infrared (NIR) photometry for three gamma-ray burst supernovae (GRB-SNe): GRB 120729A, GRB 130215A / SN 2013ez and GRB 130831A / SN 2013fu. In the case of GRB 130215A / SN 2013ez, we also present optical spectroscopy at t-t0=16.1 d, which covers rest-frame 3000-6250 Angstroms. Based on Fe II (5169) and Si (II) (6355), our spectrum indicates an unusually low expansion velocity of 4000-6350 km/s, the lowest ever measured for a GRB-SN. Additionally, we determined the brightness and shape of each accompanying SN relative to a template supernova (SN 1998bw), which were used to estimate the amount of nickel produced via nucleosynthesis during each explosion. We find that our derived nickel masses are typical of other GRB-SNe, and greater than those of SNe Ibc that are not associated with GRBs. For GRB 130831A / SN 2013fu, we use our well-sampled R-band light curve (LC) to estimate the amount of ejecta mass and the kinetic energy of the SN, finding that these too are similar to other GRB-...

  7. Data of evolutionary structure change: 1IB6D-9LDTB [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1IB6D-9LDTB 1IB6 9LDT D B -------------------MKVAVLGAAGGIGQALALLL...GGGSATLSMGQAAARFGLSLVRALQGEQGVVECAYVEG----DGQYARFFSQPLLLGKNGVEERKSIGTLSAFEQNALEGMLDT...line> LYS CA 349 9LDT B 9LDT...line> 9LDT B 9LDTB 9LDT B

  8. Data of evolutionary structure change: 1IB6D-9LDTA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1IB6D-9LDTA 1IB6 9LDT D A -------------------MKVAVLGAAGGIGQALALLL...AKAGGGSATLSMGQAAARFGLSLVRALQGEQGVVECAYVEG----DGQYARFFSQPLLLGKNGVEERKSIGTLSAFEQNALEGMLDT... TYR CA 320 ALA CA 344 9LDT A 9LDTA ISTMIKGLYGIKEN 1 9LDT A

  9. IBS SURVEY 2010: DRIVERS, BARRIERS AND CRITICAL SUCCESS FACTORS IN ADOPTING INDUSTRIALISED BUILDING SYSTEM (IBS CONSTRUCTION BY G7 CONTRACTORS IN MALAYSIA

    Directory of Open Access Journals (Sweden)

    KAMARUL ANUAR MOHAMAD KAMAR

    2014-08-01

    Full Text Available The industrialised building system (IBS survey has become an essential tool for ensuring the IBS Roadmap (2003 to 2010 meets its goals and target. As part of the process review survey, it also records the trend achievement of Malaysia in the usage of IBS in the building construction industry. The first and second IBS surveys were published in 2003 and 2005, respectively. Afterward, the IBS Roadmap’s midterm review was conducted. The third and the most recent IBS surveys were conducted in 2008 and 2010, respectively. This paper aims to highlight a part of the IBS survey report in 2010, which has been conducted to measure the drivers, barriers and the critical success factors of G7 contractors in adopting IBS construction. G7 is a Construction Industry Development Board contractor grade that can apply tender without limit. The importance of this paper is that it guides the policy and implementation strategy of IBS by G7 contractors. The survey shows that the acceptance, adoption, and deployment of IBS in the Malaysian construction industry are still low and do not address the persisting problems, such as productivity, dependency on foreign workers and high level of construction wastage.

  10. Propostas para o estudo dos protestantismos ibéricos

    OpenAIRE

    Afonso, José António

    2004-01-01

    A propósito da edição da obra “Las minorias religiosas en España y Portugal: passado y presente”, número monográfico da revista “Anales de Historia Contemporanea” (Universidade de Múrcia), o Autor elenca algumas propostas para o estudo dos protestantismos ibéricos.

  11. Level of Acceptance Towards Industrialised Building System (IBS In Malaysia

    Directory of Open Access Journals (Sweden)

    Muhamad Azani Yahya

    2012-06-01

    Full Text Available Construction practices towards conventional method is still being practiced widely even there were many researchers have done the studies on the inefficient of that method. On the other view, innovative construction had been the solution to improve the construction process flow. The need for innovation in construction industry is to enhance the efficiency for the success of project delivery. This could change the paradigm of norm construction practice which depends on conventional methods and a lot of non-value adding activities occur on that process flow. Industrialised Building System (IBS is a method introduced to Malaysian construction players and it seem significance to the industry. This concept creates a new improvement for the successes of construction project by emerging techniques and materials in efficient way. This study shows the level of acceptance toward IBS concept comparing with conventional method. Interviews and questionnaires survey were done in getting data and analysed to get the factors relating time reduction, wastage and barriers of implementing it. Result shown the perception of construction players for IBS and it will provide to all parties the credits in choosing IBS concept for the project.

  12. Al-Shāṭibīs sufismekritik:

    DEFF Research Database (Denmark)

    Riexinger, Martin Thomas

    2016-01-01

    The faqīh (Islamic legal scholar) al-Shāṭibī (d. 1388) from Granada is primarily known for his innovative approach within the field of legal theory (uṣūl al-fiqh). However, he dedicated much attention to the criticism of sufism. But like other Islamic scholars who opposed Sufism he did...

  13. Development and psychometric testing of the Visual Analogue Scale for Irritable Bowel Syndrome (VAS-IBS).

    OpenAIRE

    Ohlsson Bodil; Bengtsson Mariette; Ulander Kerstin

    2007-01-01

    Abstract Background The aim of this study was to develop and psychometrically test a short, patient-reported questionnaire to be used in clinical practice for patients with Irritable Bowel Syndrome (IBS). The Visual Analogue Scale for Irritable Bowel Syndrome (VAS-IBS) questionnaire was designed to measure the treatment response of symptoms and well-being in patients suffering from IBS. Methods The VAS-IBS was psychometrically tested for content and criterion validity, scale acceptability, it...

  14. Development and psychometric testing of the Visual Analogue Scale for Irritable Bowel Syndrome (VAS-IBS)

    OpenAIRE

    Bengtsson, Mariette; Ohlsson, Bodil; Ulander, Kerstin

    2007-01-01

    Background: The aim of this study was to develop and psychometrically test a short, patient-reported questionnaire to be used in clinical practice for patients with Irritable Bowel Syndrome (IBS). The Visual Analogue Scale for Irritable Bowel Syndrome (VAS-IBS) questionnaire was designed to measure the treatment response of symptoms and well-being in patients suffering from IBS. Methods: The VAS-IBS was psychometrically tested for content and criterion validity, scale acceptability, item-redu...

  15. A mildly relativistic radio jet from the otherwise normal Type Ic Supernova 2007gr

    CERN Document Server

    Paragi, Z; Kouveliotou, C; Granot, J; Ramirez-Ruiz, E; Bietenholz, M; van der Horst, A J; Pidopryhora, Y; van Langevelde, H J; Garrett, M A; Szomoru, A; Argo, M; Bourke, S; Paczynski, B; 10.1038/nature08713

    2010-01-01

    The class of type Ic supernovae have drawn increasing attention since 1998 owing to their sparse association (only four so far) with long duration gamma-ray bursts. Although both phenomena originate from the core collapse of a massive star, supernovae emit mostly at optical wavelengths, whereas GRBs emit mostly in soft gamma-rays or hard X-rays. Though the GRB central engine generates ultra-relativistic jets, which beam the early emission into a narrow cone, no relativistic outflows have hitherto been found in type Ib/c supernovae explosions, despite theoretical expectations and searches. Here we report radio (interferometric) observations that reveal a mildly relativistic expansion in a nearby type Ic supernova, SN 2007gr. Using two observational epochs 60 days apart, we detect expansion of the source and establish a conservative lower limit for the average apparent expansion velocity of 0.6c. Independently, a second mildly relativistic supernova has been reported. Contrary to the radio data, optical observa...

  16. El estudio de la Fauna Ibérica

    Directory of Open Access Journals (Sweden)

    Ramos Sánchez, María Ángeles

    2007-10-01

    Full Text Available Since the beginning in 1989, Fauna Ibérica has promoted coordinated research in Taxonomy bringing together more than 100 Spanish and non-Spanish experts. The programme supported by CSIC Presidency is lead by Museo Nacional de Ciencias Naturales. As a result, 30 Fauna Ibérica monographs has been published in addition to a year average of 50-60 scientific papers describing more than 50 new species per year. IBERFAUNA, the Data Bank of the Spanish Fauna, has been created including 38.000 out of the 61.000 species estimated to live in the Iberian Peninsula and Balearic Islands. This area is confirmed as one of the most biodiverse of the European Union with more than 50 % of the European species and more than 50 % of its endemics. Among future plans, a more stable organization is proposed in order to: maintaining dichotomy paper/digital publications, increasing interactivity among taxonomists and training, developing cyber-tools to facilitate public access to the information and increasing the strength of Fauna Ibérica through collaboration with other international initiatives and other areas of knowledge.Desde su inicio en 1989, Fauna Ibérica ha impulsado la investigación coordinada de más de 100 taxónomos españoles y extranjeros. El programa, apoyado por la Presidencia del CSIC, está dirigido por el Museo Nacional de Ciencias Naturales. Como resultado, se han publicado 30 monografías de la serie Fauna Ibérica, y un promedio anual de 50-60 artículos científicos que describen más de 50 nuevas especies por año. Se ha creado el Banco de Datos, IBERFAUNA, que cuenta ya con 38.000 de las aproximadamente 61.000 especies que habitan en la Península Ibérica y Baleares. Se confirma como una de las regiones más ricas en biodiversidad de la Unión Europea, con más del 50 % de las especies y más de un 50 % de sus endemismos. Entre los planes de futuro, se propone una estructura estable para Fauna Ibérica, que mantenga la dicotomía soporte

  17. SPIRITS 15c and SPIRITS 14buu: Two Obscured Supernovae in the Nearby Star-forming Galaxy IC 2163

    Science.gov (United States)

    Jencson, Jacob E.; Kasliwal, Mansi M.; Johansson, Joel; Contreras, Carlos; Castellón, Sergio; Bond, Howard E.; Monson, Andrew J.; Masci, Frank J.; Cody, Ann Marie; Andrews, Jennifer E.; Bally, John; Cao, Yi; Fox, Ori D.; Gburek, Timothy; Gehrz, Robert D.; Green, Wayne; Helou, George; Hsiao, Eric; Morrell, Nidia; Phillips, Mark; Prince, Thomas A.; Simcoe, Robert A.; Smith, Nathan; Tinyanont, Samaporn; Williams, Robert

    2017-03-01

    SPitzer InfraRed Intensive Transients Survey—SPIRITS—is an ongoing survey of nearby galaxies searching for infrared (IR) transients with Spitzer/IRAC. We present the discovery and follow-up observations of one of our most luminous (M [4.5] = ‑17.1 ± 0.4 mag, Vega) and reddest ([3.6] ‑ [4.5] = 3.0 ± 0.2 mag) transients, SPIRITS 15c. The transient was detected in a dusty spiral arm of IC 2163 (D ≈ 35.5 Mpc). Pre-discovery ground-based imaging revealed an associated, shorter-duration transient in the optical and near-IR (NIR). NIR spectroscopy showed a broad (≈8400 km s‑1), double-peaked emission line of He i at 1.083 μm, indicating an explosive origin. The NIR spectrum of SPIRITS 15c is similar to that of the Type IIb SN 2011dh at a phase of ≈200 days. Assuming an A V = 2.2 mag of extinction in SPIRITS 15c provides a good match between their optical light curves. The NIR light curves, however, show some minor discrepancies when compared with SN 2011dh, and the extreme [3.6]–[4.5] color has not been previously observed for any SN IIb. Another luminous (M 4.5 = ‑16.1 ± 0.4 mag) event, SPIRITS 14buu, was serendipitously discovered in the same galaxy. The source displays an optical plateau lasting ≳80 days, and we suggest a scenario similar to the low-luminosity Type IIP SN 2005cs obscured by A V ≈ 1.5 mag. Other classes of IR-luminous transients can likely be ruled out in both cases. If both events are indeed SNe, this may suggest that ≳18% of nearby core-collapse SNe are missed by currently operating optical surveys.

  18. QUANTITATIVE ANALYSIS ON THE LEVEL OF IBS ACCEPTANCE IN THE MALAYSIAN CONSTRUCTION INDUSTRY

    Directory of Open Access Journals (Sweden)

    MOHD SANUSI S. AHAMAD

    2011-04-01

    Full Text Available This IBS Survey report continues a practice that began in 2003. The first report was published in 2003 followed by in 2005 and in 2008. It records recent trends in selected areas that reflect Malaysia’s achievement on the IBS usage in building construction industry. Due to the dynamic economic and technological changes, IBS usage reports have been increasingly important. The design of the quantitative survey in IBS acceptance questionnaire is based on the Technology Acceptance Model (TAM. The comparison was done between the class of contractors G7 and the combined groups of G6, G5, G4. The t-test analysis shows that all the class of contractors (G7, G6, G5 and G4 have a common agreement on the awareness of IBS and IBS actual use (the benefits of using IBS in construction but have a significant difference in opinion on IBS actual use (the problems faced in using IBS and promotion of IBS by the government through CIDB, perceived ease of IBS use and perceived IBS usefulness. However, there are items in the variable that show significant difference between the comparison groups.

  19. Anti-Inflammatory Activities of a Chinese Herbal Formula IBS-20 In Vitro and In Vivo

    Directory of Open Access Journals (Sweden)

    Zhonghan Yang

    2012-01-01

    Full Text Available Irritable bowel syndrome (IBS is a functional bowel disorder and the etiology is not well understood. Currently there is no cure for IBS and no existing medication induces symptom relief in all patients. IBS-20 is a 20-herb Chinese medicinal formula that offers beneficial effects in patients with IBS; however, the underlying mechanisms are largely unknown. This study showed that IBS-20 potently inhibited LPS- or IFNΓ-stimulated expression of pro-inflammatory cytokines, as well as classically activated macrophage marker nitric oxide synthase 2. Similarly, IBS-20 or the component herb Coptis chinensis decreased LPS-stimulated pro-inflammatory cytokine secretion from JAWS II dendritic cells. IBS-20 or the component herbs also blocked or attenuated the IFNΓ-induced drop in transepithelial electric resistance, an index of permeability, in fully differentiated Caco-2 monolayer. Finally, the up-regulation of key inflammatory cytokines in inflamed colon from TNBS-treated mice was suppressed significantly by orally administrated IBS-20, including IFNΓ and IL-12p40. These data indicate that the anti-inflammatory activities of IBS-20 may contribute to the beneficial effects of the herbal extract in patients with IBS, providing a potential mechanism of action for IBS-20. In addition, IBS-20 may be a potential therapeutic agent against other Th1-dominant gut pathologies such as inflammatory bowel disease.

  20. Hydrogen for IC Engines: A Review

    Directory of Open Access Journals (Sweden)

    Vinayaka S, Syed farees khaleel rahman H.K

    2013-10-01

    Full Text Available Hydrogen provides a pathway for energy diversity. It can store the energy from diverse domestic resources (including clean coal, nuclear, and intermittently available renewables for use in mobile applications and more. Vehicles operating on hydrogen can dramatically reduce our nation’s dependence on oil and significantly reduce tailpipe emissions. Hydrogen offers a potential means to store and deliver energy from abundant, domestically available resources—while reducing our nation’s carbon footprint. This paper describes the use of Hydrogen as a fuel in IC engines and the technical aspects that accompany this idea.

  1. The eight-channel fast comparator IC

    CERN Document Server

    Alexeev, G D; Dvornikov, O V; Mikhailov, V A; Odnokloubov, I A; Tokmenin, V V

    1999-01-01

    The eight-channel fast comparator IC has been designed for high-energy physics experiments. The propagation delay is 15-36 ns and will be decreased to 7-11 ns. The output front/trailing edges are 2.2 ns and 1.8 ns at matched 110 OMEGA load. Dissipated power equals 84 mW/channel. The circuit current output can drive 30 m flat ribbon cable or twisted pair line terminated by differential line driver DS90C031.

  2. 星的细分图的IC-着色%IC-coloring of the Subdivision of Stars

    Institute of Scientific and Technical Information of China (English)

    陈剑峰

    2012-01-01

    研究了星的细分图的IC-着色问题,改进了星的细分图的IC-指数的下界,并且得到了两类图的IC-指数的一个下界。%This thesis researches the IC-coloring of the star subdivision graph,improved the lower IC-index of the star subdivision graph,and concluded two class graphs of the one lower IC-index.

  3. Medical Expenditure Panel Survey MEPSnet Insurance Component (MEPSnet/IC)

    Data.gov (United States)

    U.S. Department of Health & Human Services — The MEPS-IC is an annual survey of establishments that collects information about employer-sponsored health insurance offerings in the United States. With MEPSnet/IC...

  4. The bolometric light curves and physical parameters of stripped-envelope supernovae

    CERN Document Server

    Prentice, S J; Pian, E; Gal-Yam, A; Kulkarni, S R; Rubin, A; Corsi, A; Fremling, C; Sollerman, J; Yaron, O; Arcavi, I; Zheng, W; Kasliwal, M M; Filippenko, V V; Cenko, S B; Cao, Y; Nugent, P

    2016-01-01

    The optical and optical/near-infrared pseudobolometric light curves of 84 stripped-envelope supernovae (SNe) are constructed using a consistent method and a standard cosmology. The light curves are analysed to derive temporal characteristics and peak luminosity $L_{\\mathrm{p}}$, enabling the construction of a luminosity function. Subsequently, the mass of $^{56}$Ni synthesised in the explosion, along with the ratio of ejecta mass to ejecta kinetic energy, are found. Analysis shows that host-galaxy extinction is an important factor in accurately determining luminosity values as it is significantly greater than Galactic extinction in most cases. It is found that broad-lined SNe Ic (SNe Ic-BL) and gamma-ray burst SNe are the most luminous subtypes with a combined median $L_{\\mathrm{p}}$, in erg s$^{-1}$, of log($L_{\\mathrm{p}})=42.99$ compared to $42.51$ for SNe Ic, $42.50$ for SNe Ib, and $42.36$ for SNe IIb. It is also found that SNe Ic-BL synthesise approximately twice the amount of $^{56}$Ni compared with SN...

  5. CO observation of SNR IC 443

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    We present our 12CO and 13CO mapping observations of SNR IC 443 interacting with molecular clouds.It is the first largescale high-resolution 13CO mapping observation in the surrounding region.The morphologies of IC 443 in 12CO and 13 CO are compared with the optical,infrared,Spitzer far-infrared,X-ray,and neutral atomic gas(HI).We also make comparison and analysis in the kinematics,using the date-cubes of 12CO,13CO and HI,to help distinguish the complicated gas motions in the shocked regions.Based on the work of Wang & Scoville(1992),we present a new model to explain the coexistence of multiple shocks with different speeds in a pc-scale region at the central clump B.We test this new model by analyzing the HI and CO distribution in both velocity and space domain.We also establish the relationship between the dissociation rate of shocked molecular gas and the shock velocity in this region.Finally,we derive the optical depth of 12CO with the 13CO spectra in clump B,and discuss the validity of the assumption of optically thin emission for the shocked 12CO.

  6. Studying Radiation Tolerant ICs for LHC

    CERN Multimedia

    Faccio, F; Snoeys, W; Campbell, M; Casas-cubillos, J; Gomes, P

    2002-01-01

    %title\\\\ \\\\In the recent years, intensive work has been carried out on the development of custom ICs for the readout electronics for LHC experiments. As far as radiation hardness is concerned, attention has been focussed on high total dose applications, mainly for the tracker systems. The dose foreseen in this inner region is estimated to be higher than 1~Mrad/year. In the framework of R&D projects (RD-9 and RD-20) and in the ATLAS and CMS experiments, the study of different radiation hard processes has been pursued and good contacts with the manufacturers have been established. The results of these studies have been discussed during the Microelectronics User Group (MUG) rad-hard meetings, and now some HEP groups are working to develop radiation hard ICs for the LHC experiments on some of the available rad-hard processes.\\\\ \\\\In addition, a lot of the standard commercial electronic components and ASICs which are planned to be installed near the LHC machine and in the detectors will receive total doses in ...

  7. Electron Storage Ring Development for ICS Sources

    Energy Technology Data Exchange (ETDEWEB)

    Loewen, Roderick [Lyncean Technologies, Inc., Palo Alto, CA (United States)

    2015-09-30

    There is an increasing world-wide interest in compact light sources based on Inverse Compton Scattering. Development of these types of light sources includes leveraging the investment in accelerator technology first developed at DOE National Laboratories. Although these types of light sources cannot replace the larger user-supported synchrotron facilities, they offer attractive alternatives for many x-ray science applications. Fundamental research at the SLAC National Laboratory in the 1990’s led to the idea of using laser-electron storage rings as a mechanism to generate x-rays with many properties of the larger synchrotron light facilities. This research led to a commercial spin-off of this technology. The SBIR project goal is to understand and improve the performance of the electron storage ring system of the commercially available Compact Light Source. The knowledge gained from studying a low-energy electron storage ring may also benefit other Inverse Compton Scattering (ICS) source development. Better electron storage ring performance is one of the key technologies necessary to extend the utility and breadth of applications of the CLS or related ICS sources. This grant includes a subcontract with SLAC for technical personnel and resources for modeling, feedback development, and related accelerator physics studies.

  8. Latency represents sound frequency in mouse IC

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Frequency is one of the fundamental parameters of sound.The frequency of an acoustic stimulus can be represented by a neural response such as spike rate,and/or first spike latency(FSL)of a given neuron.The spike rates/frequency function of most neurons changes with different acoustic ampli-tudes,whereas FSL/frequency function is highly stable.This implies that FSL might represent the fre-quency of a sound stimulus more efficiently than spike rate.This study involved representations of acoustic frequency by spike rate and FSL of central inferior colliculus(IC)neurons responding to free-field pure-tone stimuli.We found that the FSLs of neurons responding to characteristic frequency(CF)of sound stimulus were usually the shortest,regardless of sound intensity,and that spike rates of most neurons showed a variety of function according to sound frequency,especially at high intensities.These results strongly suggest that FSL of auditory IC neurons can represent sound frequency more precisely than spike rate.

  9. Latency represents sound frequency in mouse IC

    Institute of Scientific and Technical Information of China (English)

    QIU Qiang; TANG Jie; YU ZuLin; ZHANG Juan; ZHOU YingJie; XIAO ZhongJu; SHEN JunXian

    2007-01-01

    Frequency is one of the fundamental parameters of sound. The frequency of an acoustic stimulus can be represented by a neural response such as spike rate, and/or first spike latency (FSL) of a given neuron. The spike rates/frequency function of most neurons changes with different acoustic amplitudes, whereas FSL/frequency function is highly stable. This implies that FSL might represent the frequency of a sound stimulus more efficiently than spike rate. This study involved representations of acoustic frequency by spike rate and FSL of central inferior colliculus (IC) neurons responding to free-field pure-tone stimuli. We found that the FSLs of neurons responding to characteristic frequency (CF) of sound stimulus were usually the shortest, regardless of sound intensity, and that spike rates of most neurons showed a variety of function according to sound frequency, especially at high intensities.These results strongly suggest that FSL of auditory IC neurons can represent sound frequency more precisely than spike rate.

  10. PDC IC WELD FAILURE EVALUATION AND RESOLUTION

    Energy Technology Data Exchange (ETDEWEB)

    Korinko, P.; Howard, S.; Maxwell, D.; Fiscus, J.

    2012-04-16

    During final preparations for start of the PDCF Inner Can (IC) qualification effort, welding was performed on an automated weld system known as the PICN. During the initial weld, using a pedigree canister and plug, a weld defect was observed. The defect resulted in a hole in the sidewall of the canister, and it was observed that the plug sidewall had not been consumed. This was a new type of failure not seen during development and production of legacy Bagless Transfer Cans (FB-Line/Hanford). Therefore, a team was assembled to determine the root cause and to determine if the process could be improved. After several brain storming sessions (MS and T, R and D Engineering, PDC Project), an evaluation matrix was established to direct this effort. The matrix identified numerous activities that could be taken and then prioritized those activities. This effort was limited by both time and resources (the number of canisters and plugs available for testing was limited). A discovery process was initiated to evaluate the Vendor's IC fabrication process relative to legacy processes. There were no significant findings, however, some information regarding forging/anneal processes could not be obtained. Evaluations were conducted to compare mechanical properties of the PDC canisters relative to the legacy canisters. Some differences were identified, but mechanical properties were determined to be consistent with legacy materials. A number of process changes were also evaluated. A heat treatment procedure was established that could reduce the magnetic characteristics to levels similar to the legacy materials. An in-situ arc annealing process was developed that resulted in improved weld characteristics for test articles. Also several tack welds configurations were addressed, it was found that increasing the number of tack welds (and changing the sequence) resulted in decreased can to plug gaps and a more stable weld for test articles. Incorporating all of the process

  11. Full chip modelling of ICs under CDM stress

    NARCIS (Netherlands)

    Sowariraj, Mary Sheela Bobby

    2005-01-01

    In this thesis, CDM ESD stress on the Integrated Circuits (IC) and the various factors which affect the robustness of an IC design against CDM stress is investigated. One of the main reasons for CDM failure are the voltage gradients set across the circuit during CDM stress. The IC being also the sou

  12. Full chip modelling of ICs under CDM stress

    NARCIS (Netherlands)

    Sowariraj, M.S.B.

    2005-01-01

    In this thesis, CDM ESD stress on the Integrated Circuits (IC) and the various factors which affect the robustness of an IC design against CDM stress is investigated. One of the main reasons for CDM failure are the voltage gradients set across the circuit during CDM stress. The IC being also the

  13. Advances in IBS 2016: A Review of Current and Emerging Data

    Science.gov (United States)

    Schoenfeld, Philip S.

    2016-01-01

    Irritable bowel syndrome (IBS) is characterized by chronic intermittent abdominal pain and associated diarrhea (IBS-D), constipation (IBS-C), or both. IBS can significantly impact patient function and quality of life. The diagnosis of IBS is based on the presence of characteristic symptoms, the exclusion of concerning features, and selected tests to exclude organic diseases that can mimic IBS. The pathophysiology of IBS remains incompletely understood, and new contributing factors have been identified over the past decade. Altered gut immune activation, intestinal permeability, and the intestinal and colonic microbiome may be important factors. Poorly absorbed carbohydrates have been implicated in triggering IBS symptoms. Increasing evidence supports the benefit of a diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs). Although there are several randomized controlled trials of probiotics in IBS, they are typically poorly designed and have not consistently demonstrated efficacy. Until recently, there were few effective treatments for IBS-D. Data from recent clinical trials support the use of rifaximin, eluxadoline, and peppermint oil. Options for the treatment of IBS-C include lubiprostone and linaclotide. PMID:28070176

  14. Crystallographic Studies of Two Bacterial AntibioticResistance Enzymes: Aminoglycoside Phosphotransferase (2')-Ic and GES-1\\beta-lactamase

    Energy Technology Data Exchange (ETDEWEB)

    Brynes, Laura; /Rensselaer Poly.

    2007-10-31

    Guiana Extended-Spectrum-1 (GES-1) and Aminoglycoside phosphotransferase (2')-Ic (APH(2')-Ic) are two bacteria-produced enzymes that essentially perform the same task: they provide resistance to an array of antibiotics. Both enzymes are part of a growing resistance problem in the medical world. In order to overcome the ever-growing arsenal of antibiotic-resistance enzymes, it is necessary to understand the molecular basis of their action. Accurate structures of these proteins have become an invaluable tool to do this. Using protein crystallography techniques and X-ray diffraction, the protein structure of GES-1 bound to imipenem (an inhibitor) has been solved. Also, APH(2')-Ic has been successfully crystallized, but its structure was unable to be solved using molecular replacement using APH(2')-Ib as a search model. The structure of GES-1, with bound imipenem was solved to a resolution of 1.89A, and though the inhibitor is bound with only moderate occupancy, the structure shows crucial interactions inside the active site that render the enzyme unable to complete the hydrolysis of the {beta}-lactam ring. The APH(2')-Ic dataset could not be matched to the model, APH(2')-Ib, with which it shares 25% sequence identity. The structural information gained from GES-1, and future studies using isomorphous replacement to solve the APH(2')-Ic structure can aid directly to the creation of novel drugs to combat both of these classes of resistance enzymes.

  15. Apocalipsis XX di Sara de Ibáñez

    Directory of Open Access Journals (Sweden)

    Stefano Tedeschi

    2013-06-01

    Full Text Available Rewriting the text of Saint John, Sara de Ibáñez uses a kind of style innovative and away from schools and trends in vogue: is thus able able to evoke the tragic experiences of the twentieth century, but the date of publication of the book (1970 reveals that it advances in themes and forms the concrete apocalypse lived by Uruguay and Latin America in the seventies. However, far from political themes and motifs, Sara de Ibáñez is able to express the absolute horror of contemporary tragedies and to propose a poetic reflection of great quality. This article suggests a rediscovery of this twentieth-century poetic voice, unjustly forgotten, through her 'apocalyptic' text.

  16. Los carófitos ibéricos

    Directory of Open Access Journals (Sweden)

    Cirujano, Santos

    2007-06-01

    Full Text Available A critical check-list of the Charophytes from the Iberian Peninsula, based on literature records and original data, is presented. It includes 46 taxa, including 26 species, 14 varieties and 6 forms, from 5 genera: Chara, Lamprothamnium, Nitella, Nitellopsis and Tolypella.Se presenta un catálogo crítico de los carófitos citados para la Península Ibérica, que comprende 46 táxones, correspondientes a 26 especies, 14 variedades y 6 formas, incluidos en 5 géneros: Chara, Lamprothamnium, Nitella, Nitellopsis y Tolypella. Para cada taxon se incluyen los sinónimos más utilizados, y su distribución ibérica.

  17. Axion Haloscopes with Toroidal Geometry at CAPP/IBS

    CERN Document Server

    Ko, B R

    2016-01-01

    The present state of the art axion haloscope employs a cylindrical resonant cavity in a solenoidal field. We, the Center for Axion and Precision Physics Research (CAPP) of the Institute for Basic Science (IBS) in Korea, are also pursuing halo axion discovery using this cylindrical geometry. However, the presence of end caps of cavities increases challenges as we explore higher frequency regions for the axion at above 2 GHz. To overcome these challenges we exploit a toroidal design of cavity and magnetic field. A toroidal geometry offers several advantages, two of which are a larger volume for a given space and greatly reduced fringe fields which interfere with our preamps, in particular the planned quantum-based devices. We introduce the concept of toroidal axion haloscopes and present ongoing research activities and plans at CAPP/IBS.

  18. Mass modelling of superthin galaxies: IC5249, UGC7321 and IC2233

    Science.gov (United States)

    Banerjee, Arunima; Bapat, Disha

    2017-04-01

    Superthin galaxies are low surface brightness (LSB) disc galaxies, characterized by optical discs with strikingly high values of planar-to-vertical axes ratios (>10), the physical origin and evolution of which continue to be a puzzle. We present mass models for three superthin galaxies: IC5249, UGC7321 and IC2233. We use high-resolution rotation curves and gas surface density distributions obtained from H I 21 cm radiosynthesis observations, in combination with their two-dimensional structural surface brightness decompositions at Spitzer 3.6 μm band, all of which were available in the literature. We find that while models with the pseudo-isothermal (PIS) and the Navarro-Frenk-White (NFW) dark matter density profiles fit the observed rotation curves of IC5249 and UGC7321 equally well, those with the NFW profile do not comply with the slowly rising rotation curve of IC2233. Interestingly, for all of our sample galaxies, the best-fitting mass models with a PIS dark matter density profile indicate a compact dark matter halo, i.e. Rc/RD < 2, where Rc is the core radius of the PIS dark matter halo and RD is the radial scalelength of the exponential stellar disc. The compact dark matter halo may be fundamentally responsible for the superthin nature of the stellar disc, and therefore our results may have important implications for the formation and evolution models of superthin galaxies in the universe.

  19. The role of stress in IBS symptom severity

    Directory of Open Access Journals (Sweden)

    Sanda Pletikosic

    2016-04-01

    Full Text Available Irritable bowel syndrome is regarded as a biopsychosocial disorder, the result of a complex combination of predisposing, precipitating and perpetuating factors. Personality traits, affective status and stress are some of the relevant factors contributing to lower quality of life and symptom exacerbation in IBS patients. In order to examine the role of stress in IBS symptom exacerbation, the aims of this study were to explore the relationship of daily stressful events and symptom severity in a prospective manner and to explore the roles of neuroticism, anxiety, depression and stress in the vicious circle of symptom perpetuation. A total of 49 patients with IBS reported their symptom severity and daily stressful events intensity each day for 14 consecutive days. They also completed the Big five personality inventory, the Beck Depression Inventory and the State-trait anxiety inventory. Cross-correlation analyses were performed on the time series data for daily stress and symptom severity for each participant separately. Four different patterns of relationships were found in different subgroups of participants: positive cross-correlations of symptom severity and stress intensity on the same day; higher symptom severity on days following stressful days; lower symptom severity on days following stressful days; and lower stress intensity on days following severe symptoms. Using average scores for daily stress and symptom severity, as well as scores for neuroticism, anxiety and depression, we performed a path analysis to test a model of symptom exacerbation. It showed that, on the group level, average stress intensity predicts average symptom severity. Neuroticism and anxiety were not significant predictors of symptom severity, while depression showed a marginally significant relationship with symptom severity, mediated by stress intensity. In conclusion, depression and daily stress seem to be important contributors to the vicious circle of IBS symptom

  20. Intravenous glucagon beneficial during colonoscopy in patient with IBS

    Directory of Open Access Journals (Sweden)

    Dharmesh H Kaswala

    2014-05-01

    Full Text Available Background and Aim: Irritable bowel syndrome (IBS is a functional bowel disorder characterized by abdominal pain or discomfort and altered bowel habits. Patients with IBS requiring colonoscopy take longer time to cecum with higher need for medications used for conscious sedation. Glucagon is routinely used during endoscopic procedures to reduce peristalsis that interfere with the procedure. However, randomized controlled data using glucagon during endoscopic procedures are lacking. We designed a prospective randomized placebo-controlled trial to study the effect of intravenous glucagon given during colonoscopy. Materials and Methods: We received approval from the FDA for this off-label use of glucagon during colonoscopy. This is a double-blind randomized placebo-controlled study. Patients were selected based on ROME III criteria for IBS; patients who met Rome III criteria and had an indication for colonoscopy for age-specific colon cancer screening or for work up of any alarm signs. We selected 34 patients meeting the Rome III for IBS and randomized into Group A and Group B. Both the performing endoscopist and patients were blinded. These patients in both groups initially received a standard dose of conscious sedation, up to 100 mcg of fentanyl and up to 5 mg of midazolam intravenously. In Group A, 17 patients, in addition to conscious sedation, received 1 ml saline as placebo. In Group B, 17 patients, in addition to conscious sedation, received 1 mg of intravenous glucagon. Parameters evaluated were as follows: 1 Total time required for colonoscopy 2 Completion of colonoscopy as documented by cecal intubation or visualization of appendicular orifice 3 Level of comfort in patient concerned to post- procedure spasmodic pain, which was based on Wong-Baker FACES pain rating scale and 4 Calculate the amount of sedation required in both groups of patients and also at what extent glucagon helped to decrease the requirement of sedatives. Data was

  1. Obstacles and Drivers in Steering IBS towards Green and Sustainability

    OpenAIRE

    2014-01-01

    The aim of this study is investigating IBS potential solution for achieving its prospective in the area of green construction and sustainability. Malaysia has embarked on initiatives for sustainable development consistent with global concerns on the environment and sustaining the world resources for the future generations. The issues of sustainability and green construction have been duly highlighted in the Construction Industry Master Plan (2005-2015) as being of significant importance for t...

  2. Progenitors of supernova Ibc: a single Wolf-Rayet star as the possible progenitor of the SN Ib iPTF13bvn

    CERN Document Server

    Groh, Jose H; Ekstrom, Sylvia

    2013-01-01

    Core-collapse supernova (SN) explosions mark the end of the tumultuous life of massive stars. Determining the nature of their progenitors is a crucial step towards understanding the properties of SNe. Until recently, no progenitor has been directly detected for SN of type Ibc, which are believed to come from massive stars that lose their Hydrogen envelope through stellar winds and from binary systems where the companion has stripped the H envelope from the primary. Here we analyze recently-reported observations of iPTF13bvn, which could possibly be the first detection of a SN Ib progenitor based on pre-explosion images. Very interestingly, the recently published Geneva models of single stars can reproduce the observed photometry of the progenitor candidate and its mass-loss rate, confirming the scenario from Cao et al 2013. We find that a single WR star with initial mass in the range 31-35 Msun fits the observed photometry of the progenitor of iPTF13bvn. The progenitor likely has a luminosity of log (L/Lsun)~...

  3. Gastrointestinal permeability (GIPerm) is increased in family members of children with functional abdominal pain (FAP) and irritable bowel syndrome (IBS)

    Science.gov (United States)

    Increased GIPerm has been described in children with FAP/IBS and adults with IBS. We sought to determine if baseline GIPerm is increased and if ibuprofen induces a greater increase in GIPerm in parents and siblings of children with FAP/IBS vs. control families without children with FAP/IBS. Site spe...

  4. Microbiota, gastrointestinal infections, low-grade inflammation, and antibiotic therapy in irritable bowel syndrome (IBS: an evidence-based review

    Directory of Open Access Journals (Sweden)

    Max Schmulson

    2014-04-01

    Conclusions: Further studies are required to determine the nature of the gut microbiota in IBS and the differences in low-grade inflammation between PI-IBS and non PI-IBS. Rifaximin has shown itself to be an effective treatment for IBS, regardless of prior factors.

  5. Illness representation, coping and outcome in irritable bowel syndrome (IBS).

    Science.gov (United States)

    Rutter, Claire L.; Rutter, Derek R.

    2002-11-01

    OBJECTIVE: Irritable bowel syndrome has no observable symptom markers and there is little that the medical profession can do to help sufferers. Psychotherapy, antidepressants and drugs aimed at the most problematic symptoms have been shown to have limited efficacy. In an attempt to help understand the illness better, and to suggest alternative forms of intervention, the study tested whether outcome might be influenced by patients' representation of their illness and by their coping strategies. METHOD: All members of the IBS Network (an independent charitable support network based in the UK) were invited to participate via their quarterly newsletter, and 209 completed questionnaires were returned. Participants completed the Illness Perception Questionnaire (IPQ), the COPE, and the Hospital Anxiety and Depression Scale (HADS), and rated their quality of life and their satisfaction with their health. RESULTS: The reporting of serious consequences was associated with lower quality of life and lower satisfaction with health, and with higher scores for anxiety and depression (p life, lower satisfaction with health, and higher depression scores (p satisfaction with health (p life (p >.05). Psychological causal attribution of IBS was positively correlated with anxiety (p depression (p link between representation and outcome; and (3) when predicting depression, coping strategies predicted coping independently of representation dimensions. CONCLUSIONS: The findings indicate that the illness representations of IBS sufferers can have significant implications for outcome. Therapeutic interventions based on illness representations may prove useful for treatment.

  6. Aluminum nitride for heatspreading in RF IC's

    Science.gov (United States)

    La Spina, L.; Iborra, E.; Schellevis, H.; Clement, M.; Olivares, J.; Nanver, L. K.

    2008-09-01

    To reduce the electrothermal instabilities in silicon-on-glass high-frequency bipolar devices, the integration of thin-film aluminum nitride as a heatspreader is studied. The AlN is deposited by reactive sputtering and this material is shown to fulfill all the requirements for actively draining heat from RF IC's, i.e., it has good process compatibility, sufficiently high thermal conductivity and good electrical isolation also at high frequencies. The residual stress and the piezoelectric character of the material, both of which can be detrimental for the present application, are minimized by a suitable choice of deposition conditions including variable biasing of the substrate in a multistep deposition cycle. Films of AlN as thick as 4 μm are successfully integrated in RF silicon-on-glass bipolar junction transistors that display a reduction of more than 70% in the value of the thermal resistance.

  7. Nanometer CMOS ICs from basics to ASICs

    CERN Document Server

    J M Veendrick, Harry

    2017-01-01

    This textbook provides a comprehensive, fully-updated introduction to the essentials of nanometer CMOS integrated circuits. It includes aspects of scaling to even beyond 12nm CMOS technologies and designs. It clearly describes the fundamental CMOS operating principles and presents substantial insight into the various aspects of design implementation and application. Coverage includes all associated disciplines of nanometer CMOS ICs, including physics, lithography, technology, design, memories, VLSI, power consumption, variability, reliability and signal integrity, testing, yield, failure analysis, packaging, scaling trends and road blocks. The text is based upon in-house Philips, NXP Semiconductors, Applied Materials, ASML, IMEC, ST-Ericsson, TSMC, etc., courseware, which, to date, has been completed by more than 4500 engineers working in a large variety of related disciplines: architecture, design, test, fabrication process, packaging, failure analysis and software.

  8. System reduction for nanoscale IC design

    CERN Document Server

    2017-01-01

    This book describes the computational challenges posed by the progression toward nanoscale electronic devices and increasingly short design cycles in the microelectronics industry, and proposes methods of model reduction which facilitate circuit and device simulation for specific tasks in the design cycle. The goal is to develop and compare methods for system reduction in the design of high dimensional nanoelectronic ICs, and to test these methods in the practice of semiconductor development. Six chapters describe the challenges for numerical simulation of nanoelectronic circuits and suggest model reduction methods for constituting equations. These include linear and nonlinear differential equations tailored to circuit equations and drift diffusion equations for semiconductor devices. The performance of these methods is illustrated with numerical experiments using real-world data. Readers will benefit from an up-to-date overview of the latest model reduction methods in computational nanoelectronics.

  9. Magnetic field structure of IC 63 and IC 59 associated with H II region Sh 185

    Science.gov (United States)

    Soam, A.; Maheswar, G.; Lee, Chang Won; Neha, S.; Andersson, B.-G.

    2017-02-01

    Bright-rimmed clouds (BRCs) are formed at the periphery of H II regions as the radiation from the central star interacts with dense gas. The ionization and resulting compression of the clouds may lead to cloud disruption causing secondary star formation depending on the stellar and gas parameters. Here we use R-band polarimetry to probe the plane-of-the sky magnetic field for two nearby BRCs, IC 59 and IC 63. Both nebulae are illuminated by γ Cas with the direction of the ionizing radiation being orientated parallel or perpendicular to the local magnetic field, allowing us to probe the importance of magnetic field pressure in the evolution of BRCs. Because of the proximity of the system (˜200 pc), we have acquired a substantial sample of over 500 polarization measurements for stars that form the background to the nebulae. On large scales, the magnetic field geometries of both clouds are anchored to the ambient magnetic field. For IC 63, the magnetic field is aligned parallel to the head-tail morphology of the main condensation, with a convex morphology relative to the direction of the ionizing radiation. We estimate the plane-of-the-sky magnetic field strength in IC 63 to be ˜ 90 μG. In IC 59, the projected magnetic field follows the M-shape morphology of the cloud. Here, field lines present a concave shape with respect to the direction of the ionizing radiation from γ Cas. Comparing our observations to published theoretical models, we find good general agreement, supporting the importance of magnetic fields in BRC evolution.

  10. Blastocystis sp. in Irritable Bowel Syndrome (IBS)--Detection in Stool Aspirates during Colonoscopy.

    Science.gov (United States)

    Ragavan, Nanthiney Devi; Kumar, Suresh; Chye, Tan Tian; Mahadeva, Sanjiv; Shiaw-Hooi, Ho

    2015-01-01

    Blastocystis is one of the most common gut parasites found in the intestinal tract of humans and animals. Its' association with IBS is controversial, possibly as a result of irregular shedding of parasites in stool and variation in stool detection. We aimed to screen for Blastocystis in colonic stool aspirate samples in adult patients with and without IBS undergoing colonoscopy for various indications and measure the interleukin levels (IL-8, IL-3 and IL-5). In addition to standard stool culture techniques, polymerase chain reaction (PCR) techniques were employed to detect and subtype Blastocystis. All the serum samples collected were subjected for ELISA studies to measure the interleukin levels (IL-8, IL-3 and IL-5). Among 109 (IBS n = 35 and non-IBS n = 74) adults, direct stool examination and culture of colonic aspirates were initially negative for Blastocystis. However, PCR analysis detected Blastocystis in 6 (17%) IBS and 4 (5.5%) non-IBS patients. In the six positive IBS patients by PCR method, subtype 3 was shown to be the most predominant (3/6: 50%) followed by subtype 4 (2/6; 33.3%) and subtype 5 (1/6; 16.6%). IL-8 levels were significantly elevated in the IBS Blasto group and IBS group (pBlastocystis-infected stools. Patients with IBS infected with parasite showed an increase in the interleukin levels demonstrate that Blastocystis does have an effect in the immune system.

  11. Integrated Baseline System (IBS), Version 1.03. User guide: Chemical Stockpile Emergency Preparedness Program

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, B.M.; Burford, M.J.; Downing, T.R.; Matsumoto, S.W.; Schrank, E.E.; Williams, J.R.; Winters, C.

    1993-01-01

    The Integrated Baseline System (IBS), operated by the Federal Emergency Management Agency (FEMA), is a system of computerized tools for emergency planing and analysis. This document is the user guide for the IBS and explains how to operate the IBS system. The fundamental function of the IBS is to provide tools that civilian emergency management personnel can use in developing emergency plans and in supporting emergency management activities to cope with a chemical-releasing event at a military chemical stockpile. Emergency management planners can evaluate concepts and ideas using the IBS system. The results of that experience can then be factored into refining requirements and plans. This document provides information for the general system user, and is the primary reference for the system features of the IBS. It is designed for persons who are familiar with general emergency management concepts, operations, and vocabulary. Although the IBS manual set covers basic and advanced operations, it is not a complete reference document set. Emergency situation modeling software in the IBS is supported by additional technical documents. Some of the other LBS software is commercial software for which more complete documentation is available. The IBS manuals reference such documentation where necessary. IBS is a dynamic system. Its capabilities are in a state of continuing expansion and enhancement.

  12. Integrated Baseline System (IBS), Version 1. 03. [Chemical Stockpile Emergency Preparedness Program

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, B.M.; Burford, M.J.; Downing, T.R.; Matsumoto, S.W.; Schrank, E.E.; Williams, J.R.; Winters, C.

    1993-01-01

    The Integrated Baseline System (IBS), operated by the Federal Emergency Management Agency (FEMA), is a system of computerized tools for emergency planing and analysis. This document is the user guide for the IBS and explains how to operate the IBS system. The fundamental function of the IBS is to provide tools that civilian emergency management personnel can use in developing emergency plans and in supporting emergency management activities to cope with a chemical-releasing event at a military chemical stockpile. Emergency management planners can evaluate concepts and ideas using the IBS system. The results of that experience can then be factored into refining requirements and plans. This document provides information for the general system user, and is the primary reference for the system features of the IBS. It is designed for persons who are familiar with general emergency management concepts, operations, and vocabulary. Although the IBS manual set covers basic and advanced operations, it is not a complete reference document set. Emergency situation modeling software in the IBS is supported by additional technical documents. Some of the other LBS software is commercial software for which more complete documentation is available. The IBS manuals reference such documentation where necessary. IBS is a dynamic system. Its capabilities are in a state of continuing expansion and enhancement.

  13. Elevated expression of c-fos in central nervous system correlates with visceral hypersensitivity in irritable bowel syndrome (IBS): a new target for IBS treatment.

    Science.gov (United States)

    Zhang, Ru; Zou, Ning; Li, Ji; Lv, Hong; Wei, Jing; Fang, Xiu-Cai; Qian, Jia-Ming

    2011-08-01

    Although visceral hypersensitivity is a major pathophysiological feature of irritable bowel syndrome (IBS), its molecular mechanisms are still poorly understood. c-fos is a well-established marker of cell activation. Accumulating evidence demonstrates that norepinephrine (NE) system is dysregulated in IBS; however, very little is known on its mechanism. It is our hypothesis that elevated expression of c-fos in central nervous system (CNS) correlates with visceral hypersensitivity in rat model of IBS. Furthermore, we explored the changes of NE system in IBS patients. The rat model of IBS was induced by heterotypic chronic and acute stress. Tissues obtained from rat model were analyzed for c-fos levels in CNS (frontal lobe, hippocampus, cornu dorsale) and colon by immunohistochemistry. Real-time reverse transcription polymerase chain reaction was used to detect tyrosine hydroxylase (TH) in the colonic tissues obtained from IBS patients. The rat model of IBS was associated with increased expression of c-fos in different parts of CNS (P = 0.001, P = 0.002, and P = 0.002, respectively), but normal in colon (P = 0.207). The clinical parameters (colonic motility and sensation) of rat model were significantly correlated with elevated c-fos in CNS (P colon were related to the elevated c-fos in CNS (P < 0.05). The TH messenger ribonucleic acid (mRNA level of IBS-D patients was almost four times as much as that of controls. Elevated expression of c-fos in CNS might be one of key mechanisms in etiology of IBS. Therefore, regulation of CNS activation could be a major targeting effect when treating IBS patients.

  14. Module comprising IC memory stack dedicated to and structurally combined with an IC microprocessor chip

    Science.gov (United States)

    Carson, John C. (Inventor); Indin, Ronald J. (Inventor); Shanken, Stuart N. (Inventor)

    1994-01-01

    A computer module is disclosed in which a stack of glued together IC memory chips is structurally integrated with a microprocessor chip. The memory provided by the stack is dedicated to the microprocessor chip. The microprocessor and its memory stack may be connected either by glue and/or by solder bumps. The solder bumps can perform three functions--electrical interconnection, mechanical connection, and heat transfer. The electrical connections in some versions are provided by wire bonding.

  15. Magnetic field structure of IC 63 and IC 59 associated to H II region - Sh 185

    CERN Document Server

    Soam, A; Lee, Chang Won; Neha, S; Andersson, B-G

    2016-01-01

    Bright-rimmed clouds (BRCs) are formed at the periphery of H$~$II regions as the radiation from the central star interacts with dense gas. The ionization and resulting compression of the clouds may lead to cloud disruption causing secondary star formation depending on the stellar and gas parameters. Here we use R-band polarimetry to probe the plane-of-the sky magnetic field in the two near-by BRCs IC\\,59 and IC\\,63. Both nebulae are illuminated by $\\gamma$ Cas with the direction of ionizing radiation being orientated parallel or perpendicular to the local magnetic field, allowing us to probe the importance of magnetic field pressure in the evolution of BRCs. Because of the proximity of the system ($\\sim$200pc) we have acquired a substantial sample of over 500 polarization measurements for stars background to the nebulae. On large scales, the magnetic field geometries of both clouds are anchored to the ambient magnetic field. For IC 63, the magnetic field is aligned parallel to the head-tail morphology of the ...

  16. Electromigration of damascene copper of IC interconnect

    Science.gov (United States)

    Meyer, William Kevin

    Copper metallization patterned with multi-level damascene process is prone to electromigration failure, which affects the reliability and performance of IC interconnect. In typical products, interconnect that is not already constrained by I·R drop or Joule self-heating operates at 'near threshold' conditions. Measurement of electromigration damage near threshold is very difficult due to slow degradation requiring greatly extended stress times, or high currents that cause thermal anomalies. Software simulations of the electromigration mechanism combined with characterization of temperature profiles allows extracting material parameters and calculation of design rules to ensure reliable interconnect. Test structures capable of demonstrating Blech threshold effects while allowing thermal characterization were designed and processed. Electromigration stress tests at various conditions were performed to extract both shortline (threshold) and long-line (above threshold) performance values. The resistance increase time constant shows immortality below Je·L (product of current density and segment length) of 3200 amp/cm. Statistical analysis of times-to-failure show that long lines last 105 hours at 3.1 mA/mum2 (120°C). While this is more robust than aluminum interconnect, the semiconductor industry will be challenged to improve that performance as future products require.

  17. Analog IC reliability in nanometer CMOS

    CERN Document Server

    Maricau, Elie

    2013-01-01

    This book focuses on modeling, simulation and analysis of analog circuit aging. First, all important nanometer CMOS physical effects resulting in circuit unreliability are reviewed. Then, transistor aging compact models for circuit simulation are discussed and several methods for efficient circuit reliability simulation are explained and compared. Ultimately, the impact of transistor aging on analog circuits is studied. Aging-resilient and aging-immune circuits are identified and the impact of technology scaling is discussed.   The models and simulation techniques described in the book are intended as an aid for device engineers, circuit designers and the EDA community to understand and to mitigate the impact of aging effects on nanometer CMOS ICs.   ·         Enables readers to understand long-term reliability of an integrated circuit; ·         Reviews CMOS unreliability effects, with focus on those that will emerge in future CMOS nodes; ·         Provides overview of models for...

  18. Deposition uniformity inspection in IC wafer surface

    Science.gov (United States)

    Li, W. C.; Lin, Y. T.; Jeng, J. J.; Chang, C. L.

    2014-03-01

    This paper focuses on the task of automatic visual inspection of color uniformity on the surface of integrated circuits (IC) wafers arising from the layering process. The oxide thickness uniformity within a given wafer with a desired target thickness is of great importance for modern semiconductor circuits with small oxide thickness. The non-uniform chemical vapor deposition (CVD) on a wafer surface will proceed to fail testing in Wafer Acceptance Test (WAT). Early detection of non-uniform deposition in a wafer surface can reduce material waste and improve production yields. The fastest and most low-priced inspection method is a machine vision-based inspection system. In this paper, the proposed visual inspection system is based on the color representations which were reflected from wafer surface. The regions of non-uniform deposition present different colors from the uniform background in a wafer surface. The proposed inspection technique first learns the color data via color space transformation from uniform deposition of normal wafer surfaces. The individual small region statistical comparison scheme then proceeds to the testing wafers. Experimental results show that the proposed method can effectively detect the non-uniform deposition regions on the wafer surface. The inspection time of the deposited wafers is quite compatible with the atmospheric pressure CVD time.

  19. LES of Gas Exchange in IC Engines

    Directory of Open Access Journals (Sweden)

    Mittal V.

    2013-10-01

    Full Text Available As engine technologies become increasingly complex and engines are driven to new operating points, understanding transient phenomena is important to ensure reliable engine operation. Unlike Reynolds Averaged Navier-Stokes (RANS studies that only provide cycle-averaged information, Large Eddy Simulation (LES studies are capable of simulating cycle-to-cycle dynamics. In this work, a finite difference based structured methodology for LES of IC engines is presented. This structured approach allows for an efficient mesh generation process and provides potential for higher order numerical accuracy. An efficient parallel scalable block decomposition is done to overcome the challenges associated with the low ratio of fluid elements to overall mesh elements. The motion of the valves and piston is handled using a dynamic cell blanking approach and the Arbitrary Lagrangian Eulerian (ALE method, respectively. Modified three-dimensional Navier-Stokes Characteristic Boundary Conditions (NSCBC are used in the simulation to prescribe conditions in the manifolds. The accuracy of the simulation framework is validated using various canonical configurations. Flow bench simulations of an axisymmetric configuration and an actual engine geometry are done with the LES methodology. Simulations of the gas exchange in an engine under motored conditions are also performed. Overall, good agreement is obtained with experiments for all the cases. Therefore, this framework can be used for LES of engine simulations. In the future, reactive LES simulations will be performed using this framework.

  20. Computer modeling of complete IC fabrication process

    Science.gov (United States)

    Dutton, Robert W.

    1987-05-01

    The development of fundamental algorithms for process and device modeling as well as novel integration of the tools for advanced Integrated Circuit (IC) technology design is discussed. The development of the first complete 2D process simulator, SUPREM 4, is reported. The algorithms are discussed as well as application to local-oxidation and extrinsic diffusion conditions which occur in CMOS AND BiCMOS technologies. The evolution of 1D (SEDAN) and 2D (PISCES) device analysis is discussed. The application of SEDAN to a variety of non-silicon technologies (GaAs and HgCdTe) are considered. A new multi-window analysis capability for PISCES which exploits Monte Carlo analysis of hot carriers has been demonstrated and used to characterize a variety of silicon MOSFET and GaAs MESFET effects. A parallel computer implementation of PISCES has been achieved using a Hypercube architecture. The PISCES program has been used for a range of important device studies including: latchup, analog switch analysis, MOSFET capacitance studies and bipolar transient device for ECL gates. The program is broadly applicable to RAM and BiCMOS technology analysis and design. In the analog switch technology area this research effort has produced a variety of important modeling and advances.

  1. The Insight of Industrialised Building System (IBS By Bumiputera Construction Players

    Directory of Open Access Journals (Sweden)

    Muhammad W. M. N. W.

    2016-01-01

    Full Text Available The term Industrialised Building System (IBS is widely recognised by construction players in Malaysia since its first implementation since 1960s for IBS pilot projects of Pekeliling Flats and Rifle Range Flats. The aim for the implementation is to promote better system in delivering construction end-products which offers efficiency and effectiveness. At the same time, Bumiputera construction players are the majority of parties in construction industry especially in Small and Medium Enterprises (SMEs. Therefore, the purpose of this paper is to identify the perception and awareness of IBS implementation among Bumiputera players. It is found that, Bumiputera construction players have sound knowledge on the IBS and optimistic towards further implementation for future projects. Nonetheless, issues on payment methods and coordination of IBS project delivery are found to be the negative perceptions which are considered as hindrance for Bumiputera construction players’ involvement in IBS project.

  2. Variations in IC(50) values with purity of mushroom tyrosinase.

    Science.gov (United States)

    Neeley, Elizabeth; Fritch, George; Fuller, Autumn; Wolfe, Jordan; Wright, Jessica; Flurkey, William

    2009-09-02

    The effects of various inhibitors on crude, commercial and partially purified commercial mushroom tyrosinase were examined by comparing IC(50) values. Kojic acid, salicylhydroxamic acid, tropolone, methimazole, and ammonium tetrathiomolybdate had relatively similar IC(50) values for the crude, commercial and partially purified enzyme. 4-Hexylresorcinol seemed to have a somewhat higher IC(50) value using crude extracts, compared to commercial or purified tyrosinase. Some inhibitors (NaCl, esculetin, biphenol, phloridzin) showed variations in IC(50) values between the enzyme samples. In contrast, hydroquinone, lysozyme, Zn(2+), and anisaldehyde showed little or no inhibition in concentration ranges reported to be effective inhibitors. Organic solvents (DMSO and ethanol) had IC(50) values that were similar for some of the tyrosinase samples. Depending of the source of tyrosinase and choice of inhibitor, variations in IC(50) values were observed.

  3. [Role of ICS/LABA on COPD treatment].

    Science.gov (United States)

    Shibata, Yoko

    2016-05-01

    In the treatment of chronic obstructive pulmonary disease (COPD), bronchodilators such as long acting muscarinic antagonist (LAMA) and long acting β agonist(LABA) play key roles for improving respiratory function and symptoms, and reducing risk of exacerbation. However, inhaled corticosteroid (ICS), a key medicine for bronchial asthma, is limitedly used in COPD treatment. Japanese Respiratory Society recommends to use ICS for severe COPD patients who have been frequently exacerbated, because previous clinical studies indicated that ICS reduces exacerbation in moderate to severe COPD patients. Asthma sometimes overlaps with COPD, and symptoms of those patients are not well controlled by the bronchodilation therapy alone. Therefore, ICS/LABA or ICS/LAMA should be prescribed to those overlapped patients. Concentration of exhaled nitrogen oxide and percentage of peripheral eosinophil may be good biomarkers for discriminating the COPD patients who have good response to ICS treatment.

  4. Guidelines for accurate EC50/IC50 estimation.

    Science.gov (United States)

    Sebaugh, J L

    2011-01-01

    This article provides minimum requirements for having confidence in the accuracy of EC50/IC50 estimates. Two definitions of EC50/IC50s are considered: relative and absolute. The relative EC50/IC50 is the parameter c in the 4-parameter logistic model and is the concentration corresponding to a response midway between the estimates of the lower and upper plateaus. The absolute EC50/IC50 is the response corresponding to the 50% control (the mean of the 0% and 100% assay controls). The guidelines first describe how to decide whether to use the relative EC50/IC50 or the absolute EC50/IC50. Assays for which there is no stable 100% control must use the relative EC50/IC50. Assays having a stable 100% control but for which there may be more than 5% error in the estimate of the 50% control mean should use the relative EC50/IC50. Assays that can be demonstrated to produce an accurate and stable 100% control and less than 5% error in the estimate of the 50% control mean may gain efficiency as well as accuracy by using the absolute EC50/IC50. Next, the guidelines provide rules for deciding when the EC50/IC50 estimates are reportable. The relative EC50/IC50 should only be used if there are at least two assay concentrations beyond the lower and upper bend points. The absolute EC50/IC50 should only be used if there are at least two assay concentrations whose predicted response is less than 50% and two whose predicted response is greater than 50%. A wide range of typical assay conditions are considered in the development of the guidelines.

  5. Variations in IC50 Values with Purity of Mushroom Tyrosinase

    OpenAIRE

    Elizabeth Neeley; George Fritch; Autumn Fuller; Jordan Wolfe; Jessica Wright; William Flurkey

    2009-01-01

    The effects of various inhibitors on crude, commercial and partially purified commercial mushroom tyrosinase were examined by comparing IC50 values. Kojic acid, salicylhydroxamic acid, tropolone, methimazole, and ammonium tetrathiomolybdate had relatively similar IC50 values for the crude, commercial and partially purified enzyme. 4-Hexylresorcinol seemed to have a somewhat higher IC50 value using crude extracts, compared to commercial or purified tyrosinase. Some inhibitors (NaCl, esculetin,...

  6. IBS-patienters upplevelse av låg FODMAP-kosten

    OpenAIRE

    Isaksson, Emma

    2012-01-01

    IBS patients experiences of eating the low FODMAP-diet Irritable bowel syndrome (IBS) is a common, functional gastrointestinal tract disorder. The disease is benign but may cause much suffering for the individual. The treatments available are used to relieve symptoms. One nutrition therapy is to exclude fermentable oligo-, di-, monosaccharide and polyols, so callde FODMAPS, from the diet. This diet is proven successful and even significantly better than the standard nutrition advice for IBS. ...

  7. Integrated Baseline System (IBS). Version 2.0, System Management Guide

    Energy Technology Data Exchange (ETDEWEB)

    Williams, J.R. [Pacific Northwest Lab., Richland, WA (United States); Bower, J.C. [Bower Software Services, Kennewick, WA (United States)

    1994-03-01

    The Integrated Baseline System (IBS) is an emergency management planning and analysis tool being developed under the direction of the US Army Nuclear and Chemical Agency. This User Guide explains how to start and use the IBS program, which is designed to help civilian emergency management personnel to plan for and support their responses to a chemical-releasing event at a military chemical stockpile. The intended audience for this document is all users of the IBS, especially emergency management planners and analysts.

  8. [Prevalence and clinical characteristics of the IBS subtypes according to the Rome III criteria in patients from a clinical, multicentric trial. A report from the Mexican IBS Working Group].

    Science.gov (United States)

    Schmulson, M; Vargas, J A; López-Colombo, A; Remes-Troche, J M; López-Alvarenga, J C

    2010-01-01

    In Mexico the prevalence of irritable bowel síndrome (IBS) using Rome II criteria varies between 16 and 35%. To analyze the relative frequency of the IBS subtypes according to the Rome III criteria. A multicentric study in 1677 IBS-Rome III patients that consulted private medical clinics. They all answered a structured interview by their physicians to determine the IBS subtype and to evaluate their symptoms intensity (Likert Scales). Patients self-evaluated their symptoms as well by using 10 cm visual analog scales for each one. Women represented 76.8% of the patients for a F:M ratio of 3.3:1. The relative frequencies of the IBS subtypes were IBS-M: 48.4%, IBS-E: 43.0%, IBS-D: 5.6% and IBS-U: 2.8% with females predominating among all. However, IBS-D included 1.7 to 2.4 times more men than any of the other subtypes. The IBS-M reported a higher frequency and intensity of halitosis and vomiting and a higher intensity of burping; while those with IBS-E reported a higher frequency and intensity of straining and the IBS-D more urgency for a bowel movement, fecal incontinence and mucous in the stools. In IBS-Rome III patients in Mexico, IBS-M is the most common subtype and is more commonly associated with dyspeptic symptoms while the IBS-E reported more outlet symptoms and the IBS-D fecal incontinence. There is a higher female predominance amongst all, however men are more likely to be in IBS-D.

  9. Los Neandertales en la Peninsula Ibérica

    Directory of Open Access Journals (Sweden)

    María Dolores Garralda

    2005-01-01

    Full Text Available Este trabajo es una síntesis de los datos existentes sobre los Neandertales encontrados en la Península Ibérica. La exposicón comienza con una breve intriducción explicando el origen del nombre con que se conoce este grupo humano, y continúa con algunas consideraciones sobre la dispersion cronológica de los Neandertales y los problemas de la identificación de sus orígenes. Los más importantes hallazgos de la península Ibérica son luego descritos, agrupándolos en cinco grandes regiones geográficas. Para cada yacimiento se detalla un resumen de los datos cronoestratigráficos y de las características antropológicas de los fósiles. Cabe recordar que muchos de ellos apareciron hace mucho tiempo, provocando que datos cruciales no hubieran sido recogidos por las circunstancias, pero también es verdad que problemas relacionados con el exacto contexto estratigráfico afectan también a algunos de los decubrimientos más recientes. La interpretación de la morfología de los restos humanos es complicada por esos difíciles problemas y además porque la mayor parte de ellos consisten en fragmentos aislados e incoimpletos. Laconclusión general es que el conjunto refleja la variabilidad inter- e intra-poblacional de los grupos Neandertales documentados en la Península Ibérica entre 170.000 y 30.000 B.P. La mayor parte de estos restos Neandertales fueron hallados con industrias Musterienses, pero algunos han aparecido con las llamadas "culturas de transición" entre el Paleolítico Medio y el Superior ; este parece ser el caso de los encontrados en la Cueva de El Castillo (nivel 18b y en Lezetxiki (niveles III y IV, todos ellos localizados en la región norte de la Península Ibérica y muy cerca de varios de los pasos naturales hacia o desde otras regiones del Suoeste de Europa.

  10. Physics for the IB diploma study and revision guide

    CERN Document Server

    Allum, John

    2017-01-01

    This Study and Revision Guide will ensure you approach your exams feeling confident and prepared through the help of accurate and accessible notes, examiner advice, and practice questions on each key topic. Written by a trusted IB Physics expert, this guide will help you: - Be aware of the essential points with key concepts and facts for each topic- Practise and check your understanding on a range of practice questions- Avoid making common mistakes with explanations of tricky concepts- Discover what you need to know to achieve the best results with advice and tips.

  11. Core-Collapse Supernovae from the Palomar Transient Factory: Indications for a Different Population in Dwarf Galaxies

    CERN Document Server

    Arcavi, Iair; Kasliwal, Mansi M; Quimby, Robert M; Ofek, Eran O; Kulkarni, Shrinivas R; Nugent, Peter E; Cenko, S Bradley; Bloom, Joshua S; Sullivan, Mark; Howell, D Andrew; Poznanski, Dovi; Filippenko, Alexei V; Law, Nicholas; Hook, Isobel; Jonsson, Jakob; Blake, Sarah; Cooke, Jeff; Dekany, Richard; Rahmer, Gustavo; Hale, David; Smith, Roger; Zolkower, Jeff; Velur, Viswa; Walters, Richard; Henning, John; Bui, Kahn; McKenna, Dan; Jacobsen, Janet

    2010-01-01

    We use the first compilation of 72 core-collapse supernovae (SNe) from the Palomar Transient Factory (PTF) to study their observed subtype distribution in dwarf galaxies compared to giant galaxies. The nature of the PTF survey provides a minimally biased sample, rich in SNe from dwarf hosts, with spectroscopic classifications. With 15 events detected in dwarf galaxies, our results are still limited by small-number statistics. However, several interesting trends emerge. We find more core-collapse SNe in dwarf galaxies than expected, with a similar N(Ib/c)/N(II) ratio in dwarf and giant hosts (0.25_{-0.15}^{+0.3} and 0.23_{-0.08}^{+0.11}, respectively), although our uncertainties (1 sigma) are still too large to distinguish between these results and those of previous studies and theoretical predictions. We use detailed subclassifications of stripped-envelope core-collapse SNe and find that all Type I core-collapse events occurring in dwarf galaxies are either SNe Ib or broad-lined SNe Ic (SNe Ic-BL), while "nor...

  12. Data Management Guide: Integrated Baseline System (IBS). Version 2.1

    Energy Technology Data Exchange (ETDEWEB)

    Bower, J.C. [Bower Software Services, Kennewick, Washington (United States); Burford, M.J.; Downing, T.R.; Moise, M.C.; Williams, J.R. [Pacific Northwest Lab., Richland, WA (United States)

    1995-01-01

    The Integrated Baseline System (IBS) is an emergency management planning and analysis tool that is being developed under the direction of the US Army Nuclear and Chemical Agency (USANCA). The IBS Data Management Guide provides the background, as well as the operations and procedures needed to generate and maintain a site-specific map database. Data and system managers use this guide to manage the data files and database that support the administrative, user-environment, database management, and operational capabilities of the IBS. This document provides a description of the data files and structures necessary for running the IBS software and using the site map database.

  13. The Type Ic SN 2007gr: a census of the ejecta from late-time optical-infrared spectra

    CERN Document Server

    Mazzali, P A; Valenti, S; Kotak, R; Hunter, D

    2010-01-01

    Nebular spectra of Supernovae (SNe) offer an unimpeded view of the inner region of the ejecta, where most nucleosynthesis takes place. Optical spectra cover most, but not all of the emitting elements, and therefore offer only a partial view of the products of the explosion. Simultaneous optical-infrared spectra, on the other hand, contain emission lines of all important elements, from C and O through to the Intermediate Mass Elements (IME) Mg, Si, S, Ca, and to Fe and Ni. In particular, Si and S are best seen in the IR. The availability of IR data makes it possible to explore in greater detail the results of the explosion. SN\\,2007gr is the first Type Ic SN for which such data are available. Modelling the spectra with a NLTE code reveals that the inner ejecta contain $\\sim 1 \\Msun$ of material within a velocity of $\\approx 4500$\\,\\kms. %The spectrum is powered by \\Nifs, in an amount ($0.076 \\Msun$) consistent with that %derived from the early-time data. The same mass of \\Nifs\\ derived from the light curve pea...

  14. Further validation of the IBS-QOL: female Mexican IBS patients have poorer quality of life than females from North Carolina.

    Science.gov (United States)

    Schmulson, Max; Ortiz, Orianna; Mejia-Arangure, Juan Manuel; Hu, Yuming B; Morris, Carolyn; Arcila, Denise; Gutierrez-Reyes, Gabriela; Bangdiwala, Shrikant; Drossman, Douglas A

    2007-11-01

    The Irritable Bowel Syndrome (IBS)-Quality of Life (QOL) is the most extensively validated health-related quality of life (HRQOL)-specific instrument for IBS with appropriate evidence for psychometric validity. Our aim was to linguistically validate the IBS-QOL for Mexico according to standard guidelines, to conduct further psychometric validation, and to compare the HRQOL between IBS patients from Mexico and North Carolina (University of North Carolina). Construct validity was tested by correlating scores from the Mexican Spanish IBS-QOL with those for anxiety and depression obtained by the Hospital Anxiety and Depression scale. Also, HRQOL from Rome I female IBS patients who consulted a tertiary referral center in Mexico was compared with that of female patients from UNC matched by age and bowel habit. A general univariate linear model was done to determine the most important variable over HRQOL, place of origin, or bowel habit. The majority of the IBS-QOL items had a negative correlation with depression as well as with anxiety. Compared to patients from UNC, the Mexican ones reported significant lower scores on Body Image and Health Worry and a trend in Interference with activities and in the Overall score. There were some differences in Dysphoria and Interference that were related to bowel habit, independently of the place of origin. In conclusion, the IBS-QOL validated in Mexican Spanish has shown construct validity. Using this instrument we found that female IBS patients who consulted a tertiary referral center in Mexico have lower HRQOL than those in North Carolina at least in factors such as Body Image and Health Worry.

  15. Comparison of the Rome IV and Rome III criteria for IBS diagnosis: A cross-sectional survey.

    Science.gov (United States)

    Bai, Tao; Xia, Jing; Jiang, Yudong; Cao, Huan; Zhao, Yong; Zhang, Lei; Wang, Huan; Song, Jun; Hou, Xiaohua

    2017-05-01

    The aims of this study were to investigate the proportion of clinical irritable bowel syndrome (IBS) at a tertiary hospital in China, to compare the Rome III and Rome IV criteria with regard to IBS diagnosis, to describe the agreement between the Rome III and Rome IV criteria, and to identify differences between Rome IV-positive and -negative IBS patients. A cross-sectional survey was performed among outpatients in the gastrointestinal (GI) department of a tertiary hospital. The patients were categorized as having IBS using Rome III and Rome IV criteria. In total, 1,376 (91.7%) patients completed a GI symptom questionnaire. Among them, 352 were suspected of having IBS and 175 were diagnosed with IBS using the Rome III or Rome IV criteria. In particular, 170 (12.4%) patients were diagnosed with IBS using the Rome III criteria, and 84 (6.1%) patients were diagnosed using the Rome IV criteria. Rome IV IBS patients experienced more pain symptoms (PRome IV IBS patients and IBS patients not diagnosed with the Rome IV criteria. Rome IV-positive IBS patients represented approximately half of Rome III-positive IBS patients at a tertiary hospital in China. More specifically, Rome IV-positive IBS was mainly a subgroup of Rome III-positive IBS with more serious symptoms. © 2016 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.

  16. Systolic array IC for genetic computation

    Science.gov (United States)

    Anderson, D.

    1991-01-01

    Measuring similarities between large sequences of genetic information is a formidable task requiring enormous amounts of computer time. Geneticists claim that nearly two months of CRAY-2 time are required to run a single comparison of the known database against the new bases that will be found this year, and more than a CRAY-2 year for next year's genetic discoveries, and so on. The DNA IC, designed at HP-ICBD in cooperation with the California Institute of Technology and the Jet Propulsion Laboratory, is being implemented in order to move the task of genetic comparison onto workstations and personal computers, while vastly improving performance. The chip is a systolic (pumped) array comprised of 16 processors, control logic, and global RAM, totaling 400,000 FETS. At 12 MHz, each chip performs 2.7 billion 16 bit operations per second. Using 35 of these chips in series on one PC board (performing nearly 100 billion operations per second), a sequence of 560 bases can be compared against the eventual total genome of 3 billion bases, in minutes--on a personal computer. While the designed purpose of the DNA chip is for genetic research, other disciplines requiring similarity measurements between strings of 7 bit encoded data could make use of this chip as well. Cryptography and speech recognition are two examples. A mix of full custom design and standard cells, in CMOS34, were used to achieve these goals. Innovative test methods were developed to enhance controllability and observability in the array. This paper describes these techniques as well as the chip's functionality. This chip was designed in the 1989-90 timeframe.

  17. Dicty_cDB: FC-IC1118 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1118 (Link to dictyBase) - - - - FC-IC1118E (Link to Original site) FC-IC... to library) Clone ID FC-IC1118 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig - Ori...re E Sequences producing significant alignments: (bits) Value FC-IC1118 (FC-IC1118Q) /CSM/FC-IC/FC-IC...%: extracellular, including cell wall 4.0 %: cytoskeletal 4.0 %: vacuolar >> prediction for FC-IC1118 is cyt 5' end seq. ID FC-IC...1118F 398 FC-IC1118Z 400 FC-IC1118P 778 FC-IC1118E 390 Show FC-IC1118 Library FC-IC (Link

  18. Dicty_cDB: FC-IC0790 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC0790 (Link to dictyBase) - - - Contig-U14940-1 FC-IC07... (Link to library) Clone ID FC-IC0790 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link t...o Contig Contig-U14940-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...y vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC0790 (FC-IC0790Q) /CSM/FC-IC/FC-IC...90E (Link to Original site) FC-IC0790F 305 FC-IC0790Z 305 FC-IC0790P 590 FC-IC0790E 295 Show FC-IC0790 Library FC-IC

  19. Dicty_cDB: FC-IC1261 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1261 (Link to dictyBase) - - - - FC-IC1261E (Link to Original site) FC-IC... to library) Clone ID FC-IC1261 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig - Ori...SM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC1760 (FC-IC1760Q) /CSM/FC-IC/FC-IC...etal 4.0 %: Golgi 4.0 %: cytoplasmic >> prediction for FC-IC1261 is end 5' end seq. ID FC-IC...1261F 255 FC-IC1261Z 439 FC-IC1261P 674 FC-IC1261E 429 Show FC-IC1261 Library FC-IC (Link

  20. Dicty_cDB: FC-IC0142 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC0142 (Link to dictyBase) - G24282 DDB0231822 Contig-U03313-1 FC-IC...tig Contig-U03313-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...E Sequences producing significant alignments: (bits) Value FC-IC0142 (FC-IC0142Q) /CSM/FC-IC/FC-IC0142Q.Seq....les of secretory system >> prediction for FC-IC0142 is cyt 5' end seq. ID FC-IC0142F 5' end seq. >FC-IC...0142F (Link to Original site) FC-IC0142F 280 - - - - - - Show FC-IC0142 Library FC-IC (Link to library) Clone ID FC-IC

  1. On the progenitor of the Type Ic SN 2013dk in the Antennae Galaxies

    CERN Document Server

    Elias-Rosa, Nancy; Maund, Justyn R; Takáts, Katalin; Fraser, Morgan; Smartt, Stephen J; Benetti, Stefano; Pignata, Giuliano; Sand, David; Valenti, Stefano

    2013-01-01

    We report the results of our search for the progenitor candidate of SN 2013dk, a Type Ic supernova (SN) that exploded in NGC 4038 in the Antennae Galaxy system (distance 22.3 Mpc). We compare pre-explosion archival images taken with the Hubble Space Telescope (HST) with SN images obtained using adaptive optics images taken with the ESO Very Large Telescope+Naos-Conica. We isolate the SN position to within 3 sigma uncertainty radius of 0.02", and show that there is no detectable point source in any of the HST filter images within the error circle. We set an upper limit to the absolute magnitude of the progenitor to be M_F555W > -5.7. In isolation, this does not allow Wolf-Rayet (WR) star progenitors to be ruled out but SN 2013dk joins the list of undetected supernova Ib/c progenitors. A bright source appears 0.17" away, which is either a single bright supergiant or compact cluster. Although the core is not obviously more extended than other point-like sources, we consider it most likely that it is a compact cl...

  2. A kinetic clutch governs uncoiling by type IB topoisomerases

    Science.gov (United States)

    Neuman, Keir

    2013-03-01

    Type IB topoisomerases (Top1B) are essential enzymes that relax excessive DNA supercoiling associated with replication and transcription and are important drug targets for cancer chemotherapy. The natural compound camptothecin (CPT) and the cancer chemotherapeutics derived from it, irinotecan and topotecan, are highly specific inhibitors of human nuclear Type IB topoisomerase (nTop1). We employed a magnetic-tweezers based single-molecule DNA supercoil relaxation assay to measure the torque dependence of human nuclear Top1 relaxation (nTop1) and inhibition by CPT. For comparison, we examined the human mitochondrial (Top1mt) topoisomerase and an N-terminal deletion mutant of nTop1 (Top68). Despite substantial sequence homology in their core domains, nTop1 and Top1mt exhibit dramatic differences in sensitivity to torque and CPT, with Top68 betraying intermediate characteristics. In particular, nTop1 displays nearly torque-independent religation probability, distinguishing it from other Top1B enzymes studied to date. Kinetic modeling reveals a hitherto unobserved torque-independent transition linking the DNA rotation and religation phases of the enzymatic cycle. The parameters of this transition determine the torque sensitivity of religation, and the efficiency of CPT binding. This ``kinetic clutch'' mechanism explains the molecular basis of CPT sensitivity and more generally provides a framework with which to interpret Top1B activity and inhibition.

  3. Obstacles and Drivers in Steering IBS towards Green and Sustainability

    Directory of Open Access Journals (Sweden)

    Seyed Meysam Khoshnava

    2014-10-01

    Full Text Available The aim of this study is investigating IBS potential solution for achieving its prospective in the area of green construction and sustainability. Malaysia has embarked on initiatives for sustainable development consistent with global concerns on the environment and sustaining the world resources for the future generations. The issues of sustainability and green construction have been duly highlighted in the Construction Industry Master Plan (2005-2015 as being of significant importance for the Malaysian construction industry. In this regard, industrialized construction has the unique characteristics to respond well to the sustainability challenge facing the construction industry. Industrialized construction assist adopters in term of cost and time certainty, attaining better construction quality and productivity, reducing risk related to occupational safety and health. But, despite all those capabilities most of the construction work in Malaysia is still applying conventional methods which are not often sustainable. Thus, this study tries to explore obstacles and drivers in steering IBS towards the agenda of green and sustainability.

  4. Numerical model of Fanuc AM100iB robot

    Science.gov (United States)

    Cholewa, A.; Świder, J.; Zbilski, A.

    2016-08-01

    The article presents a numerical model of Fanuc AM 100iB robot, prepared in the form of a block diagram in Simulink software, using the SimMechanics toolbox. The main task of the numerical model of Fanuc AM 100iB robot is to calculate the value of torques putting a load on motor shafts, and to calculate the values of kinematic parameters of the robot's arms in real time and in interactive mode. The values and format of torques putting a load on subsequent joints, and then on the motor shafts, resulted from the effect of the simultaneous action of all torques and the delay, resulting from the implementation of numerical calculations in real time. The numerical model developed is a result of design focused on recreating the effects of simultaneous action of all these factors, which are present in the actual drives and affect the consumption of electricity. A very important criterion, taken into account when designing the model, was also its computational efficiency. In addition, the model was used to visualise the work of the tested machine in three-dimensional space.

  5. [Abdominal spasms, meteorism, diarrhea: fructose intolerance, lactose intolerance or IBS?].

    Science.gov (United States)

    Litschauer-Poursadrollah, Margaritha; El-Sayad, Sabine; Wantke, Felix; Fellinger, Christina; Jarisch, Reinhart

    2012-12-01

    Meteorism, abdominal spasms, diarrhea, casually obstipation, flatulence and nausea are symptoms of fructose malabsorption (FIT) and/or lactose intolerance (LIT), but are also symptoms of irritable bowel syndrome (IBS). Therefore these diseases should be considered primarily in patients with digestive complaints. For diagnosis an H(2)-breath test is used.In 1,935 patients (526 m, 1,409 f) a fructose intolerance test and in 1,739 patients (518 m,1,221 f) a lactose intolerance test was done.FIT is found more frequently than LIT (57 versus 52 % in adults (p intolerance (HIT). Headache (ca. 10 %), fatigue (ca. 5 %) and dizziness (ca. 3 %) may occur after the test, irrespective whether the test was positive or negative.In more than 2/3 of patients a diet reduced in fructose or lactose may lead to improvement or remission of these metabolic disorders. IBS, which is often correlated with FIT (183/221 patients = 83 %), can be improved by relevant but also not relevant diets indicating that irritable bowel disease seems to be caused primarily by psychological disorders.

  6. Conceptualising Intellectual Capital (IC) as Language Game and Power

    DEFF Research Database (Denmark)

    Jørgensen, Kenneth Mølbjerg

    2006-01-01

    mainly on insights from Foucault and Wittgenstein, conceptualises IC in very generalist terms as both language game and power in order to initiate such a critical understanding. IC is perceived as a social construction and the genealogical focus is on how actors, positions and interests influence...

  7. Prometheus Reactor I&C Software Development Methodology, for Action

    Energy Technology Data Exchange (ETDEWEB)

    T. Hamilton

    2005-07-30

    The purpose of this letter is to submit the Reactor Instrumentation and Control (I&C) software life cycle, development methodology, and programming language selections and rationale for project Prometheus to NR for approval. This letter also provides the draft Reactor I&C Software Development Process Manual and Reactor Module Software Development Plan to NR for information.

  8. 30 CFR 57.22102 - Smoking (I-C mines).

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Smoking (I-C mines). 57.22102 Section 57.22102... Methane in Metal and Nonmetal Mines Fire Prevention and Control § 57.22102 Smoking (I-C mines). (a) Persons shall not smoke or carry smoking materials, matches, or lighters underground or within 50 feet...

  9. Development and psychometric testing of the Visual Analogue Scale for Irritable Bowel Syndrome (VAS-IBS

    Directory of Open Access Journals (Sweden)

    Ohlsson Bodil

    2007-05-01

    Full Text Available Abstract Background The aim of this study was to develop and psychometrically test a short, patient-reported questionnaire to be used in clinical practice for patients with Irritable Bowel Syndrome (IBS. The Visual Analogue Scale for Irritable Bowel Syndrome (VAS-IBS questionnaire was designed to measure the treatment response of symptoms and well-being in patients suffering from IBS. Methods The VAS-IBS was psychometrically tested for content and criterion validity, scale acceptability, item-reduction, internal reliability consistency, simplicity, and speed. Two samples were used. One expert panel (five physicians and four registered nurses, who gave their opinion on the content validity, and one of 71 patients with IBS (mean age 38 years SD +13, range 19–65, who completed the VAS-IBS, as well as the Gastrointestinal Symptom Rating Scale and the Psychological General Well-Being Index for criterion validity. Results The items in the VAS-IBS capture the main physical concerns women with IBS might present and the psychometric testing confirmed that the VAS-IBS is an acceptable homogeneous patient-reported questionnaire indicated by Cronbach's alpha internal consistency reliability coefficient, with a value of 0.85. All correlations to test the criterion validity performed by using Pearson's correlation test, were statistically significant (p Conclusion The VAS-IBS appears to be reliable and user-friendly, for patients as well as for health professionals. The final version of the VAS-IBS including nine items needs to be further tested in clinical practice cross-culturally in women as well as in men.

  10. Dicty_cDB: FC-IC0282 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC0282 (Link to dictyBase) - - - Contig-U16527-1 - (Link to Original site) FC-IC...(Link to library) Clone ID FC-IC0282 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig ...Contig-U16527-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...ogy vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC1760 (FC-IC1760Q) /CSM/FC-IC/FC-IC...0282F 255 FC-IC0282Z 429 FC-IC0282P 673 FC-IC0282E 429 Show FC-IC0282 Library FC-IC

  11. Dicty_cDB: FC-IC0374 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC0374 (Link to dictyBase) - - - Contig-U12354-1 FC-IC03... (Link to library) Clone ID FC-IC0374 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link t...o Contig Contig-U12354-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...les of secretory system >> prediction for FC-IC0374 is end 5' end seq. ID FC-IC0374F 5' end seq. >FC-IC...74E (Link to Original site) FC-IC0374F 223 FC-IC0374Z 324 FC-IC0374P 547 FC-IC0374E 324 Show FC-IC0374 Library FC-IC

  12. Dicty_cDB: FC-IC1268 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1268 (Link to dictyBase) - - - Contig-U16527-1 FC-IC12...ink to library) Clone ID FC-IC1268 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Co...ntig-U16527-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...lpy*iw Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC1760 (FC-IC1760Q) /CSM/FC-IC/FC-IC...68P (Link to Original site) FC-IC1268F 231 FC-IC1268Z 250 FC-IC1268P 461 - - Show FC-IC1268 Library FC-IC (L

  13. Optical Follow-Up Observations of PTF10qts, a Luminous Broad-Lined Type Ic Supernova Found by the Palomar Transient Factory

    CERN Document Server

    Walker, E S; Pian, E; Hurley, K; Arcavi, I; Cenko, S B; Gal-Yam, A; Horesh, A; Kasliwal, M; Poznanski, D; Silverman, J M; Sullivan, M; Bloom, J S; Filippenko, A V; Kulkarni, S R; Nugent, P E; Ofek, E; Barthelmy, S; Boynton, W; Goldsten, J; Golenetskii, S; Ohno, M; Tashiro, M S; Yamaoka, K; Zhang, X L-

    2014-01-01

    We present optical photometry and spectroscopy of the broad-lined Type Ic supernova (SNIc-BL) PTF10qts, which was discovered as part of the Palomar Transient Factory. The supernova was located in a dwarf galaxy of magnitude $r=21.1$ at a redshift $z=0.0907$. We find that the $R$-band light curve is a poor proxy for bolometric data and use photometric and spectroscopic data to construct and constrain the bolometric light curve. The derived bolometric magnitude at maximum light is $M_{\\rm bol} = -18.51\\pm0.2$ mag, comparable to that of SN 1998bw ($M_{\\rm bol} = -18.7$ mag) which was associated with a gamma-ray burst (GRB). PTF10qts is one of the most luminous SNIc-BL observed without an accompanying GRB. We estimate the physical parameters of the explosion using data from our programme of follow-up observations, finding that it produced a larger mass of radioactive nickel compared to other SNeIc-BL with similar inferred ejecta masses and kinetic energies. The progenitor of the event was likely a $\\sim20$M$_{\\od...

  14. Exclusion of the GNAS locus in PHP-Ib patients with broad GNAS methylation changes: evidence for an autosomal recessive form of PHP-Ib?

    Science.gov (United States)

    Fernández-Rebollo, Eduardo; Pérez de Nanclares, Guiomar; Lecumberri, Beatriz; Turan, Serap; Anda, Emma; Pérez-Nanclares, Gustavo; Feig, Denice; Nik-Zainal, Serena; Bastepe, Murat; Jüppner, Harald

    2011-08-01

    Most patients with autosomal dominant pseudohypoparathyroidism type Ib (AD-PHP-Ib) carry maternally inherited microdeletions upstream of GNAS that are associated with loss of methylation restricted to GNAS exon A/B. Only few AD-PHP-Ib patients carry microdeletions within GNAS that are associated with loss of all maternal methylation imprints. These epigenetic changes are often indistinguishable from those observed in patients affected by an apparently sporadic PHP-Ib form that has not yet been defined genetically. We have now investigated six female patients affected by PHP-Ib (four unrelated and two sisters) with complete or almost complete loss of GNAS methylation, whose healthy children (11 in total) showed no epigenetic changes at this locus. Analysis of several microsatellite markers throughout the 20q13 region made it unlikely that PHP-Ib is caused in these patients by large deletions involving GNAS or by paternal uniparental isodisomy or heterodisomy of chromosome 20 (patUPD20). Microsatellite and single-nucleotide variation (SNV) data revealed that the two affected sisters share their maternally inherited GNAS alleles with unaffected relatives that lack evidence for abnormal GNAS methylation, thus excluding linkage to this locus. Consistent with these findings, healthy children of two unrelated sporadic PHP-Ib patients had inherited different maternal GNAS alleles, also arguing against linkage to this locus. Based on our data, it appears plausible that some forms of PHP-Ib are caused by homozygous or compound heterozygous mutation(s) in an unknown gene involved in establishing or maintaining GNAS methylation.

  15. A unique set of SH3-SH3 interactions controls IB1 homodimerization

    DEFF Research Database (Denmark)

    Kristensen, Ole; Guenat, Sylvie; Dar, Imran

    2006-01-01

    reduces IB1-dependent basal JNK activity in 293T cells. Impaired dimerization also results in a reduction in glucose transporter type 2 expression and in glucose-dependent insulin secretion in pancreatic beta-cells. Taken together, these results indicate that IB1 homodimerization through its SH3 domain...

  16. Data of evolutionary structure change: 1IB6B-9LDTB [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1IB6B-9LDTB 1IB6 9LDT B B -------------------MKVAVLGAAGGIGQALALLL...GGGSATLSMGQAAARFGLSLVRALQGEQGVVECAYVEG----DGQYARFFSQPLLLGKNGVEERKSIGTLSAFEQNALEGMLDT...ne>VAL CA 288 9LDT B 9LDT...tryChain> 9LDT B 9LDT...2 ILE CA 466 ILE CA 392 9LDT

  17. Data of evolutionary structure change: 1IB6B-9LDTA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1IB6B-9LDTA 1IB6 9LDT B A -------------------MKVAVLGAAGGIGQALALLL...GGGSATLSMGQAAARFGLSLVRALQGEQGVVECAYVEG----DGQYARFFSQPLLLGKNGVEERKSIGTLSAFEQNALEGMLDT...YS CA 351 9LDT A 9LDT...A 487 LEU CA 486 ASP CA 492 ILE CA 466 9LDT... A 9LDTA RVIGSGCNL

  18. Data of evolutionary structure change: 1IB6C-9LDTA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1IB6C-9LDTA 1IB6 9LDT C A -------------------MKVAVLGAAGGIGQALALLL...GGGSATLSMGQAAARFGLSLVRALQGEQGVVECAYVEG----DGQYARFFSQPLLLGKNGVEERKSIGTLSAFEQNALEGMLDT...5 9LDT A 9LDTA LEU CA 482 ASP CA 492 ILE CA 464 9LDT... A 9LDTA RVIGSGCN

  19. Data of evolutionary structure change: 1IB6C-9LDTB [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1IB6C-9LDTB 1IB6 9LDT C B -------------------MKVAVLGAAGGIGQALALLL...GGGSATLSMGQAAARFGLSLVRALQGEQGVVECAYVEG----DGQYARFFSQPLLLGKNGVEERKSIGTLSAFEQNALEGMLDT.../line> VAL CA 288 9LDT B 9LDT... 9 9LDT B... 9LDTB SDVVK-VTLTP - H

  20. Contractors’ Perspective on the Benefits of Implementing Industrialized Building System (IBS

    Directory of Open Access Journals (Sweden)

    Mohd Hanizun Hanafi

    2015-08-01

    Full Text Available Construction industry is considered among the most crucial sectors in developing countries where it is capable to drive a nation towards progressive development as it provides a positive platform to other industries. Implementation of Industrialized Building System (IBS has been acknowledged as an effective measure to increase capability within the industry as compared to the conventional methods. The purpose of this study is to present the benefits of implementing IBS from contractors’ viewpoint. Questionnaire forms were distributed to 683 construction firms registered under the Construction Industry Development Board of Malaysia operating in the states of Penang, Selangor, Kuala Lumpur and Johor. A total of 254 questionnaire forms were returned duly completed. The collected data was analysed using the Conformity Index. Three main benefits gained by implementing IBS from the contractors’ perspective are (1 IBS increases the productivity of construction works, (2 IBS reduces concrete mixing activities at construction sites and (3 IBS reduces the overall duration of construction work. These results indicate that the contractors are focusing more on completing construction works with the help of IBS implementation at construction sites. Also with IBS, it is able to minimize the problem of site mismanagement/disorganization through a significant reduction of in-situ wet concrete works.

  1. Neuroimmune interactions at different intestinal sites are related to abdominal pain symptoms in children with IBS

    Science.gov (United States)

    Neuroimmune interactions and inflammation have been proposed as factors involved in sensory-motor dysfunction and symptom generation in adult irritable bowel syndrome (IBS) patients. In children with IBS and healthy controls, we measured ileocolonic mast cell infiltration and fecal calprotectin and ...

  2. Data of evolutionary structure change: 1IB6D-1LLDA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1IB6D-1LLDA 1IB6 1LLD D A -MKVAVLGAAGGIGQALALLLKTQLPSGSELSLYDIAP-...ELVGATVNILKAIMPNLVKVAPNAIYMLITNPVDIATHVAQKLTG----LPENQIFGSGTNLDSARLRFLIAQQTGVNVK--NVHAYIAGEHGDS-EVPLWESATIGGVPMSDWTPLPGHDPLDA... 1LLD A 1LLDA EVLDMQ...ine>ILE CA 464 1LLD A 1LLDA... SER CA 536 1LLD A 1LLDA

  3. Expression and induction of secretory phospholipase A2 group IB in brain

    DEFF Research Database (Denmark)

    Kolko, Miriam; Christoffersen, Nanna R; Varoqui, Hélène

    2005-01-01

    as in neurons in primary culture. The distribution of sPLA2-IB seems to be mainly neuronal, with the highest abundance occurring in the cerebral cortex and hippocampus. We also find that genes encoding sPLA2-IB are induced by kainic acid and by electroshock-induced convulsions. Based on the present results we...

  4. The Implications Related to Different IC, Different Projects and Different Thinking Addressing the Common Core of IC

    DEFF Research Database (Denmark)

    Lindgren, Peter; Saghaug, Kristin Margrethe

    2009-01-01

    Purpose - In the field of innovation of business models on behalf of networks of different intellectual capabilities (ICA), the development of Intellectual Capital (IC) are highly in focus. An increased work of innovation in groups, projects and by individuals outside the core of the organization...... challenge the development of IC: - The IC at the organizational level seems to diminish when innovation gets highly dispersed and is operated outside the core of the organization - The attractiveness of the organization to different ICA, which is one fundament to sustainable and successful innovation, seems...... to fall when the IC at the organizational core level diminishes The objective of this paper is therefore to understand 1) How the IC at the organizational core level may continue to be developed, when at the same time innovation is taking place in dispersed groups and projects. 2) How to motivate...

  5. System design and integration analysis for the Integrated Booking System (IBS)

    Energy Technology Data Exchange (ETDEWEB)

    Truett, L.F.; Wheeler, V.V.; Grubb, J.W. [Oak Ridge National Laboratory, TN (United States); Grubb, J.W.; Faby, E.Z. [Univ. of Tennessee, Knoxville, TN (United States)

    1995-11-01

    In accordance with tasking for the Military Traffic Management Command (MTMC), the Oak Ridge National Laboratory (ORNL) investigated design and integration issues and identified specific options for MTMC`s Integrated Booking System (IBS). Three system designs are described: the single-server, stand-alone IBS; the area-based IBS; and the fully-integrated IBS. Because of the functional and technical requirements of IBS and because of the MTMC strategy of sharing resources, ORNL recommends the fully-integrated design. This option uses the excess computing resources provided through the architectural components of the Integrated Cargo Database (ICDB) and provides visibility over the cargo record from initial request through final delivery.

  6. Psychometric assessment of the IBS-D Daily Symptom Diary and Symptom Event Log.

    Science.gov (United States)

    Rosa, Kathleen; Delgado-Herrera, Leticia; Zeiher, Bernie; Banderas, Benjamin; Arbuckle, Rob; Spears, Glen; Hudgens, Stacie

    2016-12-01

    Diarrhea-predominant irritable bowel syndrome (IBS-D) can considerably impact patients' lives. Patient-reported symptoms are crucial in understanding the diagnosis and progression of IBS-D. This study psychometrically evaluates the newly developed IBS-D Daily Symptom Diary and Symptom Event Log (hereafter, "Event Log") according to US regulatory recommendations. A US-based observational field study was conducted to understand cross-sectional psychometric properties of the IBS-D Daily Symptom Diary and Event Log. Analyses included item descriptive statistics, item-to-item correlations, reliability, and construct validity. The IBS-D Daily Symptom Diary and Event Log had no items with excessive missing data. With the exception of two items ("frequency of gas" and "accidents"), moderate to high inter-item correlations were observed among all items of the IBS-D Daily Symptom Diary and Event Log (day 1 range 0.67-0.90). Item scores demonstrated reliability, with the exception of the "frequency of gas" and "accidents" items of the Diary and "incomplete evacuation" item of the Event Log. The pattern of correlations of the IBS-D Daily Symptom Diary and Event Log item scores with generic and disease-specific measures was as expected, moderate for similar constructs and low for dissimilar constructs, supporting construct validity. Known-groups methods showed statistically significant differences and monotonic trends in each of the IBS-D Daily Symptom Diary item scores among groups defined by patients' IBS-D severity ratings ("none"/"mild," "moderate," or "severe"/"very severe"), supporting construct validity. Initial psychometric results support the reliability and validity of the items of the IBS-D Daily Symptom Diary and Event Log.

  7. The role of 5-HT7 Receptor in the pathogenesis of IBS

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Objective:To investigate the role of 5-HT7 receptor in the pathogenesis of irritable bowel syndrome(IBS). Methods:Rat model of D-IBS was established by intracolonic instillation of acetic acid and restraint stress; Rat model of C-IBS was established by stomach irrigated with 0-4℃ cool water daily for 14 d. The content and distribution of 5-HT7 receptor at the brain and bowel was examined by immunohistochemistry and the expression of 5-HT7 receptor mRNA was detected by fluorescence quantitative RT-PCR(Real-time PCR). Results:Immunocytochemistry result showed the 5-HT7 rceptor positive staining at hippocampus and hypothalamus of both C-IBS and D-IBS group was stronger than that of control group(P<0.01). The 5-HT7R expression at ileum, proximate colon, distal colon of C-IBS group was significantly stronger than that of control group(P<0.05). Realtime-PCR analysis results showed the expression level of 5-HT7 receptor at hippocampus and hypothalamus of both C-IBS and D-IBS group was increased than that of control group(P<0.05). At proximal and distal colon of C-IBS group, the 5-HT7 receptor mRNA expression was increased compared with control group(P<0.05). Conclusion:The up-regulated expression of 5-HT7 receptor at brain and colon may play an important role in the pathogenesis of C-IBS.

  8. Aportaciones coloniales a las creencias funerarias ibéricas

    Directory of Open Access Journals (Sweden)

    Joaquín García Raya

    1999-01-01

    Full Text Available La «mediterraneidad» de la península ibérica ha producido una serie de contactos con otros pueblos de esta cuenca, atraídos por su riqueza minera o como recurso a la colmatación de sus territorios de origen, lo cual produjo una traslación de ritos funerarios, cuya lectura arqueológica ha significado interpretaciones erróneas básicas.The "Mediterranean style» of the Iberian Península has given way to a series of contacts wth otherpeoples fron this valley, attracted by its mining richness and as an option tgo the overcrowding of their native territories. This brought about the implantation of funeral ceremonies, who archaelogical reading has meant false interpretations.

  9. Dicty_cDB: FC-IC0618 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC0618 (Link to dictyBase) - - - Contig-U07877-1 FC-IC06...ink to library) Clone ID FC-IC0618 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Co...ntig-U07877-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...les of secretory system >> prediction for FC-IC0618 is cyt 5' end seq. ID FC-IC0618F 5' end seq. >FC-IC...18P (Link to Original site) FC-IC0618F 583 FC-IC0618Z 169 FC-IC0618P 732 - - Show FC-IC0618 Library FC-IC (L

  10. Dicty_cDB: FC-IC1558 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1558 (Link to dictyBase) - - - Contig-U15578-1 FC-IC15...ink to library) Clone ID FC-IC1558 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Co...ntig-U15578-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...y system 4.0 %: peroxisomal >> prediction for FC-IC1558 is cyt 5' end seq. ID FC-IC1558F 5' end seq. >FC-IC1...58P (Link to Original site) FC-IC1558F 205 FC-IC1558Z 298 FC-IC1558P 483 - - Show FC-IC1558 Library FC-IC (L

  11. Dicty_cDB: FC-IC1004 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1004 (Link to dictyBase) - G24305 DDB0232093 Contig-U13941-1 FC-IC... (Link to library) Clone ID FC-IC1004 (Link to dictyBase) Atlas ID - NBRP ID G24305 dic...mrvimmwlinkl*i*slkvvhylllvw*hslracv Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC... 4.0 %: mitochondrial >> prediction for FC-IC1004 is cyt 5' end seq. ID FC-IC1004F 5' end seq. >FC-IC...1004E (Link to Original site) FC-IC1004F 187 FC-IC1004Z 187 FC-IC1004P 354 FC-IC1004E 177 Show FC-IC1004 Library FC-IC

  12. Dicty_cDB: FC-IC1504 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1504 (Link to dictyBase) - - - Contig-U07877-1 FC-IC15... (Link to library) Clone ID FC-IC1504 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link ...to Contig Contig-U07877-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...0104Q) /CSM/FC-IC/FC-IC0104Q.Seq.d/ 533 e-151 own update 2001.11.19 Homology vs DNA Score E Sequences producing signific...04E (Link to Original site) FC-IC1504F 581 FC-IC1504Z 583 FC-IC1504P 1144 FC-IC1504E 573 Show FC-IC1504 Library FC-IC

  13. Dicty_cDB: FC-IC0422 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC0422 (Link to dictyBase) - - - Contig-U16233-1 FC-IC04...22Z (Link to Original site) - - FC-IC0422Z 549 - - - - Show FC-IC0422 Library FC-IC (Link to library) Clone ID FC-IC... vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC0422 (FC-IC0422Q) /CSM/FC-IC/FC-IC...0422 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Contig-U16233-1 Original site URL http://dic...tycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC0422Q.Seq.d/ Representative seq. ID FC-IC

  14. Dicty_cDB: FC-IC1498 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1498 (Link to dictyBase) - - - Contig-U16527-1 FC-IC14... (Link to library) Clone ID FC-IC1498 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link t...o Contig Contig-U16527-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...xiyldilxlrnhxk Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC1760 (FC-IC...98E (Link to Original site) FC-IC1498F 438 FC-IC1498Z 439 FC-IC1498P 857 FC-IC1498E 429 Show FC-IC1498 Library FC-IC

  15. Dicty_cDB: FC-IC1278 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1278 (Link to dictyBase) - - - Contig-U12354-1 FC-IC12... (Link to library) Clone ID FC-IC1278 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link t...o Contig Contig-U12354-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC... 16.0 %: nuclear 8.0 %: cytoskeletal 8.0 %: plasma membrane >> prediction for FC-IC1278 is cyt 5' end seq. ID FC-IC...78E (Link to Original site) FC-IC1278F 334 FC-IC1278Z 334 FC-IC1278P 648 FC-IC1278E 324 Show FC-IC1278 Library FC-IC

  16. Dicty_cDB: FC-IC0929 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC0929 (Link to dictyBase) - - - Contig-U16527-1 FC-IC09...ink to library) Clone ID FC-IC0929 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Co...ntig-U16527-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...les of secretory system >> prediction for FC-IC0929 is end 5' end seq. ID FC-IC0929F 5' end seq. >FC-IC...29P (Link to Original site) FC-IC0929F 313 FC-IC0929Z 320 FC-IC0929P 613 - - Show FC-IC0929 Library FC-IC (L

  17. Dicty_cDB: FC-IC1321 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1321 (Link to dictyBase) - - - Contig-U15335-1 FC-IC13... (Link to library) Clone ID FC-IC1321 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link t...o Contig Contig-U15335-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...0 %: mitochondrial 4.0 %: vacuolar 4.0 %: endoplasmic reticulum >> prediction for FC-IC1321 is cyt 5' end seq. ID FC-IC...21E (Link to Original site) FC-IC1321F 194 FC-IC1321Z 194 FC-IC1321P 368 FC-IC1321E 184 Show FC-IC1321 Library FC-IC

  18. Dicty_cDB: FC-IC0181 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC0181 (Link to dictyBase) - - - Contig-U03326-1 FC-IC01...81F (Link to Original site) FC-IC0181F 553 - - - - - - Show FC-IC0181 Library FC-IC (Link to library) Clone ID FC-IC... Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC0181 (FC-IC0181Q) /CSM/FC-IC/FC-IC...ulum >> prediction for FC-IC0181 is cyt 5' end seq. ID FC-IC0181F 5' end seq. >FC-IC...0181 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Contig-U03326-1 Original site URL http://dic

  19. Dicty_cDB: FC-IC0175 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC0175 (Link to dictyBase) - - - Contig-U13957-1 FC-IC01...75F (Link to Original site) FC-IC0175F 212 - - - - - - Show FC-IC0175 Library FC-IC (Link to library) Clone ID FC-IC...e E Sequences producing significant alignments: (bits) Value FC-IC0175 (FC-IC0175Q) /CSM/FC-IC/FC-IC0175Q.Se...letal 4.0 %: vacuolar >> prediction for FC-IC0175 is cyt 5' end seq. ID FC-IC0175F 5' end seq. >FC-IC0175F.S...0175 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Contig-U13957-1 Original site URL http://dic

  20. Dicty_cDB: FC-IC0169 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC0169 (Link to dictyBase) - - - Contig-U15064-1 FC-IC01...69F (Link to Original site) FC-IC0169F 288 - - - - - - Show FC-IC0169 Library FC-IC (Link to library) Clone ID FC-IC...0169 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Contig-U15064-1 Original site URL http://dic...tycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC0169Q.Seq.d/ Representative seq. ID FC-IC...0169F (Link to Original site) Representative DNA sequence >FC-IC0169 (FC-IC0169Q) /CSM/FC-IC/FC-IC

  1. Considerations for IC and Component Selection for Space Systems

    Science.gov (United States)

    LaBel, Kenneth A.; Cohn, Lewis M.

    2008-01-01

    This viewgraph presentation addresses the integrated cycling and component selection technologies for aerospace systems. The topics include: 1) Semiconductors: The Evolution of ICs - Availability and Technology; 2) IC Selection Requirements - three fields of thought, "The Good", "The Bad" and "The Ugly"; 3) Reliability and Radiation; 4) Radiation Perspective-Four methods of selecting ICs for space systems, Guaranteed hardness, historical ground-based radiation data, historical flight usage, and unknown assurance; 5) Understanding Risk, including risk trade space and ASICs and FPGA sample selection criteria.

  2. Membership, lithium and chromospheric activity of the young open clusters IC 2391, IC 2602 and IC 4665 from GES (Gaia-ESO Survey) observations

    Science.gov (United States)

    Gómez Garrido, M.; Montes, D.; Gutiérrez Albarrán, M. L.; Tabernero, H. M.; Gónzalez Hernández, J. I.; GES Survey Builders

    2017-03-01

    We conduct a comparative study of the main properties of the of the young open clusters IC 2391, IC 2602 and IC 4665, focusing on their membership, lithium abundance and level of chromospheric activity and possible accretion. We use the fundamental parameters (effective temperature, surface gravity, and radial velocity) delivered by the Gaia-ESO survey (GES - https://www.gaia-eso.eu/) consortium in the four internal data release (iDR4) to select the members of these clusters among the UVES and GIRAFFE spectroscopic observations. Chromospheric activity criterium, and iterative process between radial velocity distribution and lithium-temperature diagram are applied to determinate what objects are members or non members of the clusters. All this information allowed us to characterize the properties of the members of these clusters and identify some field contaminant lithium-rich giants.

  3. Gastrointestinal (GI) permeability is associated with trait anxiety in children with functional abdominal pain (FAP) and Irritable Bowel Syndrome (IBS)

    Science.gov (United States)

    FAP and IBS affect 10-15% of school age children and bear many physiological similarities to irritable bowel syndrome (IBS) in adults (e.g., functional pain, visceral hyperalgesia). Animal models of IBS have suggested a relationship between neonatal stress and increased GI permeability later in life...

  4. 30 CFR 57.22202 - Main fans (I-A, I-B, I-C, II-A, III, V-A, and V-B mines).

    Science.gov (United States)

    2010-07-01

    ... reverse airstream shall be approved by MSHA under the appliable requirements of 30 CFR part 18; (2) Drive... alloy fan blades shall not contain more than 0.5 percent magnesium. . (d) When an internal combustion... vented to the atomsphere so that exhaust cannot contaminate mine intake air. (e) For Subcategory...

  5. Statistical studies of supernova environments

    CERN Document Server

    Anderson, Joseph P; Habergham, Stacey M; Galbany, Lluís; Kuncarayakti, Hanindyo

    2015-01-01

    Investigations of the environments of SNe allow statistical constraints to be made on progenitor properties. We review progress that has been made in this field. Pixel statistics using tracers of e.g. star formation within galaxies show differences in the explosion sites of, in particular SNe types II and Ibc (SNe II and SNe Ibc), suggesting differences in population ages. Of particular interest is that SNe Ic are significantly more associated with H-alpha emission than SNe Ib, implying shorter lifetimes for the former. In addition, such studies have shown that the interacting SNe IIn do not explode in regions containing the most massive stars, which suggests that at least a significant fraction of their progenitors arise from the lower end of the core-collapse SN mass range. Host HII region spectroscopy has been obtained for a significant number of core-collapse events, however definitive conclusions have to-date been elusive. Single stellar evolution models predict that the fraction of SNe Ibc to SNe II sho...

  6. Interband cascade (IC) photovoltaic (PV) architecture for PV devices

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Rui Q.; Tian, Zhaobing; Mishima, Tetsuya D.; Santos, Michael B.; Johnson, Matthew B.; Klem, John F.

    2015-10-20

    A photovoltaic (PV) device, comprising a PV interband cascade (IC) stage, wherein the IC PV stage comprises an absorption region with a band gap, the absorption region configured to absorb photons, an intraband transport region configured to act as a hole barrier, and an interband tunneling region configured to act as an electron barrier. An IC PV architecture for a photovoltaic device, the IC PV architecture comprising an absorption region, an intraband transport region coupled to the absorption region, and an interband tunneling region coupled to the intraband transport region and to the adjacent absorption region, wherein the absorption region, the intraband transport region, and the interband tunneling region are positioned such that electrons will flow from the absorption region to the intraband transport region to the interband tunneling region.

  7. IC-BASED CONTROLS FOR ENERGY-EFFICIENT LIGHTING

    Energy Technology Data Exchange (ETDEWEB)

    Richard Zhang

    2005-03-01

    A new approach for driving high frequency energy saving ballasts is developed and documented in this report. The developed approach utilizes an IC-based platform that provides the benefits of reduced system cost, reduced ballast size, and universal application to a wide range of lamp technologies, such as linear fluorescent lamps (LFL), compact fluorescent lamps (CFL) and high intensity discharge lamps (HID). The control IC chip set developed for the platform includes dual low voltage (LV) IC gate drive that provides gate drive for high and low side power switches in typical ballast circuits, and ballast controller IC that provides control functionalities optimal for different lamps and digital interface for future extension to more sophisticated control and communication.

  8. Acoustic source data for medium speed IC-engines

    OpenAIRE

    Hynninen, A.; Turunen, R.; Åbom, Mats; Bodén, Hans

    2011-01-01

    Knowledge of the acoustic source characteristics of internal combustion engines (IC-engines) is of great importance when designing the exhaust duct system and its components to withstand the resulting dynamic loads and to reduce the exhaust noise emission. Number of studies has been published earlier on the low frequency in-duct exhaust noise of high speed engines. The goal of the present study is to investigate the medium speed IC-engine acoustic source characteristics numerically and experi...

  9. Comparability of Mixed IC50 Data – A Statistical Analysis

    OpenAIRE

    Tuomo Kalliokoski; Christian Kramer; Anna Vulpetti; Peter Gedeck

    2013-01-01

    The biochemical half maximal inhibitory concentration (IC50) is the most commonly used metric for on-target activity in lead optimization. It is used to guide lead optimization, build large-scale chemogenomics analysis, off-target activity and toxicity models based on public data. However, the use of public biochemical IC50 data is problematic, because they are assay specific and comparable only under certain conditions. For large scale analysis it is not feasible to check each data entry man...

  10. Missing the Mark: Is ICS Training Achieving Its Goal

    Science.gov (United States)

    2016-12-01

    need to be mutually exclusive of classroom- teaching methods , there is evidence to suggest exclusively networked learning can be effective, and can be...system to engage the social learning required for successful cultural change. The thesis also critiques the ICS training measurement method and...to engage the social learning required for successful cultural change. The thesis also critiques the ICS training measurement method and recommends

  11. Revealing Hanny's Voorwerp: radio observations of IC 2497

    CERN Document Server

    Jozsa, G I G; Oosterloo, T A; Rampadarath, H; Paragi, Z; van Arkel, H; Lintott, C; Keel, W C; Schawinski, K; Edmondson, E

    2009-01-01

    We present multi-wavelength radio observations in the direction of the spiral galaxy IC 2497 and the neighbouring emission nebula known as "Hanny's Voorwerp". Our WSRT continuum observations at 1.4 GHz and 4.9 GHz, reveal the presence of extended emission at the position of the nebulosity, although the bulk of the emission remains unresolved at the centre of the galaxy. e-VLBI 1.65 GHz observations show that on the milliarcsecond-scale a faint central compact source is present in IC 2497 with a brightness temperature in excess of 4E5 K. With the WSRT, we detect a large reservoir of neutral hydrogen in the proximity of IC 2497. One cloud complex with a total mass of 5.6E9 Msol to the South of IC 2497, encompasses Hanny's Voorwerp. Another cloud complex is located at the position of a small galaxy group ~100 kpc to the West of IC 2497 with a mass of 2.9E9 Msol. Our data hint at a physical connection between both complexes. We also detect HI in absorption against the central continuum source of IC 2497. Our obse...

  12. Dicty_cDB: FC-IC1367 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1367 (Link to dictyBase) - - - - FC-IC1367E (Link to Original site) FC-IC... to library) Clone ID FC-IC1367 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig - Ori...cytoskeletal 8.0 %: mitochondrial 4.0 %: vacuolar 4.0 %: endoplasmic reticulum >> prediction for FC-IC1367 i...1367F 271 FC-IC1367Z 271 FC-IC1367P 522 FC-IC1367E 261 Show FC-IC1367 Library FC-IC (Link...ginal site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC1367Q.Seq.d/ Rep

  13. Dicty_cDB: FC-IC1728 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1728 (Link to dictyBase) - - - - - (Link to Original site) - - FC-IC...1728Z 373 - - - - Show FC-IC1728 Library FC-IC (Link to library) Clone ID FC-IC1728 (Link to dic...tyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig - Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC1785 (FC-IC1785Q) /CSM/FC-IC/FC-IC...6.0 %: plasma membrane 12.0 %: mitochondrial 4.0 %: cytoskeletal 4.0 %: Golgi 4.0 %: cytoplasmic >> prediction for FC-IC

  14. Dicty_cDB: FC-IC1667 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1667 (Link to dictyBase) - - - Contig-U16382-1 FC-IC16... (Link to library) Clone ID FC-IC1667 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link t...o Contig Contig-U16382-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...y vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC1667 (FC-IC1667Q) /CSM/FC-IC/FC-IC...%: mitochondrial 8.0 %: nuclear >> prediction for FC-IC1667 is mit 5' end seq. ID FC-IC1667F 5' end seq. >FC-IC

  15. Dicty_cDB: FC-IC0107 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC0107 (Link to dictyBase) - - - - FC-IC0107F (Link to Original site) FC-IC...0107F 430 - - - - - - Show FC-IC0107 Library FC-IC (Link to library) Clone ID FC-IC0107 (Link to dic...tyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig - Original site URL http://dictycdb.bi...ore E Sequences producing significant alignments: (bits) Value FC-IC0107 (FC-IC0107Q) /CSM/FC-IC/FC-IC0107Q.Seq.d/ 258 6e-68 FC-IC...asma membrane 12.0 %: mitochondrial 4.0 %: cytoskeletal 4.0 %: Golgi 4.0 %: cytoplasmic >> prediction for FC-IC

  16. Dicty_cDB: FC-IC1423 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1423 (Link to dictyBase) - - - Contig-U16122-1 FC-IC14... (Link to library) Clone ID FC-IC1423 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link t...o Contig Contig-U16122-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...mitochondrial 4.0 %: cytoskeletal 4.0 %: Golgi 4.0 %: vesicles of secretory system >> prediction for FC-IC14...23E (Link to Original site) FC-IC1423F 250 FC-IC1423Z 254 FC-IC1423P 484 FC-IC1423E 244 Show FC-IC1423 Library FC-IC

  17. Dicty_cDB: FC-IC1251 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1251 (Link to dictyBase) - - - Contig-U08307-1 FC-IC12...Link to library) Clone ID FC-IC1251 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig C...ontig-U08307-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC... 4.0 %: plasma membrane >> prediction for FC-IC1251 is mit 5' end seq. ID FC-IC...51P (Link to Original site) FC-IC1251F 648 FC-IC1251Z 650 FC-IC1251P 1278 - - Show FC-IC1251 Library FC-IC (

  18. Dicty_cDB: FC-IC1707 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1707 (Link to dictyBase) - - - Contig-U13402-1 FC-IC17... (Link to library) Clone ID FC-IC1707 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link ...to Contig Contig-U13402-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...tracellular, including cell wall 8.0 %: endoplasmic reticulum 4.0 %: cytoskeletal 4.0 %: peroxisomal >> prediction for FC-IC...07E (Link to Original site) FC-IC1707F 532 FC-IC1707Z 533 FC-IC1707P 1045 FC-IC1707E 523 Show FC-IC1707 Library FC-IC

  19. Dicty_cDB: FC-IC0095 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC0095 (Link to dictyBase) - G24277 DDB0231825 Contig-U03300-1 FC-IC...tig Contig-U03300-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC... vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC0095 (FC-IC0095Q) /CSM/FC-IC/FC-IC...0095F (Link to Original site) FC-IC0095F 288 - - - - - - Show FC-IC0095 Library FC-IC (Link to library) Clone ID FC-IC...0095 (Link to dictyBase) Atlas ID - NBRP ID G24277 dictyBase ID DDB0231825 Link to Con

  20. Dicty_cDB: FC-IC0932 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC0932 (Link to dictyBase) - - - - - (Link to Original site) - - FC-IC...0932Z 239 - - - - Show FC-IC0932 Library FC-IC (Link to library) Clone ID FC-IC0932 (Link to dic...tyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig - Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC... 8.0 %: extracellular, including cell wall 4.0 %: cytoskeletal >> prediction for FC-IC0932 is mit 5' ...te) Representative DNA sequence >FC-IC0932 (FC-IC0932Q) /CSM/FC-IC/FC-IC0932Q.Seq.d/ XXXXXXXXXXTCACCAATGTTGA

  1. Dicty_cDB: FC-IC1144 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1144 (Link to dictyBase) - - - Contig-U15215-1 FC-IC11...Link to library) Clone ID FC-IC1144 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig C...ontig-U15215-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...tochondrial 32.0 %: nuclear 16.0 %: cytoplasmic 4.0 %: cytoskeletal >> prediction for FC-IC1144 is mit 5' end seq. ID FC-IC...44P (Link to Original site) FC-IC1144F 715 FC-IC1144Z 681 FC-IC1144P 1376 - - Show FC-IC1144 Library FC-IC (

  2. Dicty_cDB: FC-IC1678 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1678 (Link to dictyBase) - - - Contig-U16583-1 FC-IC16... (Link to library) Clone ID FC-IC1678 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link t...o Contig Contig-U16583-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...s Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC1678 (FC-IC1678Q) /CSM/FC-IC/FC-IC... 8.0 %: cytoskeletal 8.0 %: mitochondrial >> prediction for FC-IC1678 is nuc 5' end seq. ID FC-IC1678F 5' end seq. >FC-IC

  3. Dicty_cDB: FC-IC0522 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC0522 (Link to dictyBase) - G24294 DDB0169466 Contig-U03376-1 FC-IC... (Link to library) Clone ID FC-IC0522 (Link to dictyBase) Atlas ID - NBRP ID G24294 dic...tnfski*ki rniyklsislc Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC0522 (FC-IC... 12.0 %: cytoskeletal 8.0 %: mitochondrial 4.0 %: vacuolar >> prediction for FC-IC...0522E (Link to Original site) FC-IC0522F 215 FC-IC0522Z 215 FC-IC0522P 430 FC-IC0522E 215 Show FC-IC0522 Library FC-IC

  4. Dicty_cDB: FC-IC0335 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC0335 (Link to dictyBase) - - - Contig-U08330-1 FC-IC03... (Link to library) Clone ID FC-IC0335 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link t...o Contig Contig-U08330-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...0 m_ : 1.00 44.0 %: cytoplasmic 40.0 %: nuclear 12.0 %: mitochondrial 4.0 %: plasma membrane >> prediction for FC-IC...35E (Link to Original site) FC-IC0335F 270 FC-IC0335Z 270 FC-IC0335P 540 FC-IC0335E 270 Show FC-IC0335 Library FC-IC

  5. Dicty_cDB: FC-IC1095 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1095 (Link to dictyBase) - - - Contig-U10067-1 FC-IC10... (Link to library) Clone ID FC-IC1095 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link t...o Contig Contig-U10067-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC1156 (FC-IC...%: cytoskeletal 12.0 %: mitochondrial 4.0 %: vacuolar 4.0 %: Golgi >> prediction for FC-IC

  6. Pseudohypoparathyroidism type Ib associated with novel duplications in the GNAS locus.

    Directory of Open Access Journals (Sweden)

    Gustavo Perez-Nanclares

    Full Text Available Pseudohypoparathyroidism type 1b (PHP-Ib is characterized by renal resistance to PTH (and, sometimes, a mild resistance to TSH and absence of any features of Albright's hereditary osteodystrophy. Patients with PHP-Ib suffer of defects in the methylation pattern of the complex GNAS locus. PHP-Ib can be either sporadic or inherited in an autosomal dominant pattern. Whereas familial PHP-Ib is well characterized at the molecular level, the genetic cause of sporadic PHP-Ib cases remains elusive, although some molecular mechanisms have been associated with this subtype.The aim of the study was to investigate the molecular and imprinting defects in the GNAS locus in two unrelated patients with PHP-Ib.We have analyzed the GNAS locus by direct sequencing, Methylation-Specific Multiplex Ligation-dependent Probe Amplification, microsatellites, Quantitative Multiplex PCR of Short Fluorescent fragments and array-Comparative Genomic Hybridization studies in order to characterize two unrelated families with clinical features of PHP-Ib.We identified two duplications in the GNAS region in two patients with PHP-Ib: one of them, comprising ∼ 320 kb, occurred 'de novo' in the patient, whereas the other one, of ∼ 179 kb in length, was inherited from the maternal allele. In both cases, no other known genetic cause was observed.In this article, we describe the to-our-knowledge biggest duplications reported so far in the GNAS region. Both are associated to PHP-Ib, one of them occurring 'de novo' and the other one being maternally inherited.

  7. Migraine, fibromyalgia, and depression among people with IBS: a prevalence study

    Directory of Open Access Journals (Sweden)

    Cabral Howard J

    2006-09-01

    Full Text Available Abstract Background Case descriptions suggest IBS patients are more likely to have other disorders, including migraine, fibromyalgia, and depression. We sought to examine the prevalence of these conditions in cohorts of people with and without IBS. Methods The source of data was a large U.S. health plan from January 1, 1996 though June 30, 2002. We identified all people with a medical claim associated with an ICD-9 code for IBS. A non-IBS cohort was a random sample of people with an ICD-9 code for routine medical care. In the cohorts, we identified all claims for migraine, depression, and fibromyalgia. We estimated the prevalence odds ratios (PORs of each of the three conditions using the Mantel-Haenszel method. We conducted quantitative sensitivity analyses to quantify the impact of residual confounding and in differential outcome identification. Results We identified 97,593 people in the IBS cohort, and a random sample of 27,402 people to compose the non-IBS comparison cohort. With adjustment, there was a 60% higher odds in the IBS cohort of having any one of the three disorders relative to the comparison cohort (POR 1.6, 95% CI 1.5 – 1.7. There was a 40% higher odds of depression in the IBS cohort (POR 1.4, 95% CI 1.3 – 1.4. The PORs for fibromyalgia and migraine were similar (POR for fibromyalgia 1.8, 95% CI 1.7 – 1.9; POR for migraine 1.6, 95% CI 1.4 – 1.7. Differential prevalence of an unmeasured confounder, or imperfect sensitivity or specificity of outcome detection would have impacted the observed results. Conclusion People in the IBS cohort had a 40% to 80% higher prevalence odds of migraine, fibromyalgia, and depression.

  8. Moving from irrelevant intellectual capital (IC) reporting to value-relevant IC disclosures: key learning points from the Danish experience

    DEFF Research Database (Denmark)

    Roslender, Robin; Schaper, Stefan; Nielsen, Christian

    2017-01-01

    Purpose – Informed by the findings of a follow-up research study of companies originally involved in the Danish Guideline Project (DGP) for intellectual capital statements (ICS), the purpose of this paper is to provide valuable insights for a potential shift from intellectual capital (IC) reporting......, largely informed by an accounting perspective, towards IC-related disclosures. Design/methodology/approach – The paper draws on data obtained from 21 semi-structured interviews with respondents in 16 companies. The respondents were contacted following a genealogical exercise carried out on the 102...... structure. Overall, a trend towards more integrated forms of reporting was discernible, in some part being motivated by the need to reduce the levels of reporting overload. Examples of integration designed to legitimise IC or corporate social responsibility reports, involving issuing them in tandem...

  9. Dependence of nitrogen concentration in type Ib diamonds on synthesis temperature

    Institute of Scientific and Technical Information of China (English)

    TIAN Yu; JIA XiaoPeng; ZANG ChuanYi; LI ShangSheng; XIAO HongYu; ZHANG YaFei; HUANG GuoFeng; LI Rui; HAN QiGang; MA LiQiu; LI Yong; CHEN XiaoZhou; ZHANG Chong; MA HongAn

    2009-01-01

    Type Ib diamonds were grown by the temperature gradient method (TGM) at 5.5 GPa and 1500-1560 K in a china-type cubic anvil high pressure apparatus using Ni70Mn25Co5 alloy as solvent/catalyst. The concentration of nitrogen (CN) in type Ib diamonds synthesized at different synthesis temperatures was measured by a Fourier transform infrared (FTIR) spectrometer. The dependence of CN in diamond on synthesis temperature was studied. For the type Ib diamonds synthesized using Ni70Mn25Co5 as catalyst, its CN decreases along with the increase of synthesis temperature.

  10. Non-parametric study of the evolution of the cosmological equation of state with SNeIa, BAO and high redshift GRBs

    CERN Document Server

    Postnikov, Sergey; Hernandez, Xavier; Capozziello, Salvatore

    2014-01-01

    We study the dark energy equation of state as a function of redshift in a non-parametric way, without imposing any {\\it a priori} $w(z)$ (ratio of pressure over energy density) functional form. As a check of the method, we test our scheme through the use of synthetic data sets produced from different input cosmological models which have the same relative errors and redshift distribution as the real data. Using the luminosity-time $L_{X}-T_{a}$ correlation for GRB X-ray afterglows (the Dainotti et al. correlation), we are able to utilize GRB sample from the {\\it Swift} satellite as probes of the expansion history of the Universe out to $z \\approx 10$. Within the assumption of a flat FLRW universe and combining SNeIa data with BAO constraints, the resulting maximum likelihood solutions are close to a constant $w=-1$. If one imposes the restriction of a constant $w$, we obtain $w=-0.99 \\pm 0.06$ (consistent with a cosmological constant) with the present day Hubble constant as $H_{0}=70.0 \\pm 0.6$ ${\\rm km} \\, {\\...

  11. Dicty_cDB: FC-IC0564 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC0564 (Link to dictyBase) - - - Contig-U16036-1 FC-IC05...ink to library) Clone ID FC-IC0564 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Co...ntig-U16036-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC... Score E Sequences producing significant alignments: (bits) Value FC-IC0564 (FC-IC0564Q) /CSM/FC-IC/FC-IC056...lar, including cell wall 4.0 %: cytoskeletal 4.0 %: vacuolar >> prediction for FC-IC0564 is cyt 5' end seq. ID FC-IC

  12. Dicty_cDB: FC-IC0216 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC0216 (Link to dictyBase) - G24287 DDB0201591 Contig-U0... (Link to library) Clone ID FC-IC0216 (Link to dictyBase) Atlas ID - NBRP ID G24287 dictyBase I...D DDB0201591 Link to Contig Contig-U03331-1 Original site URL http://dictycdb.bio... 4.0 %: mitochondrial 4.0 %: peroxisomal >> prediction for FC-IC0216 is nuc 5' end seq. ID FC-IC0216F 5' end seq. >FC-IC...3331-1 - (Link to Original site) FC-IC0216F 315 FC-IC0216Z 315 FC-IC0216P 630 FC-IC0216E 315 Show FC-IC0216 Library FC-IC

  13. Dicty_cDB: FC-IC0364 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC0364 (Link to dictyBase) - - - Contig-U01120-1 - (Link to Original site) FC-IC...(Link to library) Clone ID FC-IC0364 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig ...Contig-U01120-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...re E Sequences producing significant alignments: (bits) Value FC-IC0364 (FC-IC0364Q) /CSM/FC-IC/FC-IC0364Q.S...24.0 %: nuclear 8.0 %: cytoplasmic 4.0 %: cytoskeletal >> prediction for FC-IC0364 is mit 5' end seq. ID FC-IC

  14. Dicty_cDB: FC-IC0491 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC0491 (Link to dictyBase) - - - Contig-U12373-1 FC-IC04... (Link to library) Clone ID FC-IC0491 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link ...to Contig Contig-U12373-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...omology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC1285 (FC-IC1285Q) /CSM/FC-IC/FC-IC...ear 12.0 %: cytoskeletal 4.0 %: mitochondrial 4.0 %: peroxisomal >> prediction for FC-IC0491 is cyt 5' end seq. ID FC-IC

  15. Dicty_cDB: FC-IC1222 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1222 (Link to dictyBase) - - - Contig-U11840-1 FC-IC12...ink to library) Clone ID FC-IC1222 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Co...ntig-U11840-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...equences producing significant alignments: (bits) Value FC-IC1222 (FC-IC1222Q) /CSM/FC-IC/FC-IC1222Q.Seq.d/ ...%: Golgi 4.0 %: plasma membrane 4.0 %: vesicles of secretory system >> prediction for FC-IC1222 is end 5' end seq. ID FC-IC

  16. Dicty_cDB: FC-IC1569 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1569 (Link to dictyBase) - - - Contig-U16026-1 FC-IC15... (Link to library) Clone ID FC-IC1569 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link t...o Contig Contig-U16026-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC1569 (FC-IC1569Q) /CSM/FC-IC/FC-IC...les of secretory system >> prediction for FC-IC1569 is end 5' end seq. ID FC-IC

  17. Dicty_cDB: FC-IC1756 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1756 (Link to dictyBase) - - - Contig-U16026-1 FC-IC17...ink to library) Clone ID FC-IC1756 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Co...ntig-U16026-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...isomal 4.0 %: extracellular, including cell wall 4.0 %: vacuolar 4.0 %: vesicles of secretory system >> prediction for FC-IC...56P (Link to Original site) FC-IC1756F 156 FC-IC1756Z 284 FC-IC1756P 420 - - Show FC-IC1756 Library FC-IC (L

  18. Dicty_cDB: FC-IC1753 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1753 (Link to dictyBase) - - - - - (Link to Original site) - - FC-IC...1753Z 284 - - - - Show FC-IC1753 Library FC-IC (Link to library) Clone ID FC-IC1753 (Link to dic...tyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig - Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...te) Representative DNA sequence >FC-IC1753 (FC-IC1753Q) /CSM/FC-IC/FC-IC1753Q.Seq.d/ XXXXXXXXXXTGTGTTTTGGAGT...vllvlgwlelvllvle*lelvwlvlvwlelv*lelgllfl eykeehp*ihllgnmnmklqiyldilslrnhmk Homology vs CSM-cDNA Score E Sequences producing signific

  19. Dicty_cDB: FC-IC0417 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC0417 (Link to dictyBase) - - - Contig-U03353-1 FC-IC04...17F (Link to Original site) FC-IC0417F 285 - - - - - - Show FC-IC0417 Library FC-IC (Link to library) Clone ID FC-IC... %: cytoskeletal 4.0 %: vacuolar >> prediction for FC-IC0417 is nuc 5' end seq. ID FC-IC...0417 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Contig-U03353-1 Original site URL http://dic...tycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC0417Q.Seq.d/ Representative seq. ID FC-IC

  20. El Águila Imperial Ibérica

    Directory of Open Access Journals (Sweden)

    M. Ferrer Baena

    2005-01-01

    Full Text Available El Á guila Imperial Ibérica es una de las aves más amenazadas de extinción del mundo. Actualmente, la población mundial de la especie está estimada en un poco más de 200 parejas. Todas ellas se encuentran en territorio peninsular español, en los bosques mediterráneos del cuadrante suroccidental, repartidas en una serie de subpoblaciones de pequeño tamaño (menos de 30 parejas con un nivel de intercambio medio‐bajo, estando algunas de ellas claramente aisladas. Este tipo de distribución es típicamente inestable y paso previo habitual de los procesos de extinción. Entre las principales amenazas a la especie se encuentran la disminución de las poblaciones de conejo, que constituye su principal presa, y la mortalidad por electrocución en tendidos eléctricos.

  1. Ocular Shock Front in the Colliding Galaxy IC 2163

    CERN Document Server

    Kaufman, Michele; Struck, Curtis; Elmegreen, Debra Meloy; Bournard, Frederic; Brinks, Elias; Juneau, Stephanie; Sheth, Kartik

    2016-01-01

    ALMA observations in the CO 1 - 0 line of the interacting galaxies IC 2163 and NGC 2207 at 2'' x 1.5'' resolution reveal how the encounter drives gas to pile up in narrow, ~ 1 kpc wide, "eyelids" in IC 2163. IC 2163 and NGC 2207 are involved in a grazing encounter, which has led to development in IC 2163 of an eye-shaped (ocular) structure at mid-radius and two tidal arms. The CO data show that there are large velocity gradients across the width of each eyelid, with a mixture of radial and azimuthal streaming of gas at the outer edge of the eyelid relative to its inner edge. The sense of the radial streaming in the eyelids is consistent with the idea that gas from the outer part of IC 2163 flows inward until its radial streaming slows down abruptly and the gas piles up in the eyelids. The radial compression at the eyelids causes an increase in the gas column density by direct radial impact and also leads to a high rate of shear. We find a strong correlation between the molecular column densities and the magni...

  2. Spectroscopic classification of SN2017gvr as a peculiar type Ib SN

    Science.gov (United States)

    Martinez, Jorge; Galbany, L.; Gonzalez-Gaitan, S.; Forster, F.

    2017-09-01

    We report the spectroscopic classification of SN2017gvr as a peculiar type Ib supernova discovered by the OGLE-IV Real-time Transient Search (Wyrzykowski et al., 2014 arxiv:1409.1095; http://ogle.astrouw.edu.pl/).

  3. [Antagonists of the type 3 serotonin receptor (5 -HT3) in IBS].

    Science.gov (United States)

    Komoto, Shunsuke; Miura, Soichiro

    2006-08-01

    Irritable bowel syndrome (IBS) is a common chronic gastrointestinal (GI) disorder, but its pathophysiology remains unknown. 5-hydroxytryptamine (5-HT, serotonin) is an important neurotransmitter involved in the brain-gut connection. Alosetron, a 5-HT3 receptor antagonist, has been demonstrated in randomized, placebo-controlled trials (RCT) to be effective in diarrhea-predominant IBS(IBS-D). Constipation is the most common adverse event. Alosetron improved abdominal pain and discomfort and stool consistency in both female and male patients, but it did not improve other symptoms (sense of urgency, stool frequency and bloating) in male patients. Although less is known about the gender differences in therapeutic benefit, a new 5-HT3 antagonist, cilansetron, has demonstrated effectiveness in male and female IBS-D patients and is currently under clinical trials.

  4. Una pequeña "addenda a Post-incunables ibéricos"

    OpenAIRE

    Paolini, Devid

    2010-01-01

    Una puesta al día de Post-incunables ibéricos de Martín Abad acerca de una edición de Lucio Flaminio que se conserva en la Biblioteca Universitaria de Salamanca. An update to Post-incunables ibéricos by Martín Abad concerning an edition of Lucio Flaminio held at the Biblioteca Universitaria de Salamanca.

  5. Dicty_cDB: FC-IC1182 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1182 (Link to dictyBase) - - - Contig-U07877-1 FC-IC11...Link to library) Clone ID FC-IC1182 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig C...ontig-U07877-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...kl*s*swfrcctnsycwsffksfncsw **psycmwtlan* Homology vs CSM-cDNA Score E Sequences producing significant align...les of secretory system >> prediction for FC-IC1182 is cyt 5' end seq. ID FC-IC

  6. Dicty_cDB: FC-IC1622 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1622 (Link to dictyBase) - - - Contig-U16527-1 FC-IC16... (Link to library) Clone ID FC-IC1622 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link t...o Contig Contig-U16527-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...k tnntssnhpktnntssnhsktnhtssnysktnntspnntspninsysrldfipnsnkrsr tmrimlgic**cst*isl...ghllvvqhlnlvtllnm Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC1760 (FC-IC

  7. A Unified Submodular Framework for Multimodal IC Trojan Detection

    Science.gov (United States)

    Koushanfar, Farinaz; Mirhoseini, Azalia; Alkabani, Yousra

    This paper presents a unified formal framework for integrated circuits (IC) Trojan detection that can simultaneously employ multiple noninvasive measurement types. Hardware Trojans refer to modifications, alterations, or insertions to the original IC for adversarial purposes. The new framework formally defines the IC Trojan detection for each measurement type as an optimization problem and discusses the complexity. A formulation of the problem that is applicable to a large class of Trojan detection problems and is submodular is devised. Based on the objective function properties, an efficient Trojan detection method with strong approximation and optimality guarantees is introduced. Signal processing methods for calibrating the impact of inter-chip and intra-chip correlations are presented. We propose a number of methods for combining the detections of the different measurement types. Experimental evaluations on benchmark designs reveal the low-overhead and effectiveness of the new Trojan detection framework and provides a comparison of different detection combining methods.

  8. Effects of omitting elective neck irradiation to nodal Level IB in nasopharyngeal carcinoma patients with negative Level IB lymph nodes treated by intensity-modulated radiotherapy: a Phase 2 study.

    Science.gov (United States)

    Li, Mei; Huang, Xiao-Guang; Yang, Zhi-Ning; Lu, Jia-Yang; Zhan, Yi-Zhou; Xie, Wen-Jia; Zhou, Dong-Jie; Wang, Li; Zhu, Di-Xia; Lin, Zhi-Xiong

    2016-09-01

    To investigate the need for elective neck irradiation (ENI) to nodal Level IB in patients with nasopharyngeal carcinoma (NPC) with negative Level IB lymph nodes (IB-negative) treated by intensity-modulated radiotherapy (IMRT). We conducted a Phase 2 prospective study in 123 newly diagnosed IB-negative patients with NPC treated by IMRT, who met at least 1 of the following criteria: (1) unilateral or bilateral Level II involvement with 1 of the following: Level IIA involvement or any Level II node ≥2 cm/with extracapsular spread; (2) ≥2 unilateral node-positive regions. Bilateral Level IB nodes were not contoured as part of the treatment target and treated electively. Level IB regional recurrence rate; pattern of treatment failure; 3-year overall survival (3y-OS), 3-year local control (3y-LC) and 3-year regional control (3y-RC) rates; toxicities; and dosimetric data for planning target volumes, organs at risk, Level IB and submandibular glands (SMGs) were evaluated. Two patients developed failures at Level IB (1.6%). The 3y-LC, 3y-RC and 3y-OS rates were 93.5%, 93.5% and 78.0%, respectively. Bilateral Level IB received unplanned high-dose irradiation with a mean dose (Dmean) ≥50 Gy in 60% of patients. The average Dmean of bilateral SMGs was approximately 53 Gy. ENI to Level IB may be unnecessary in IB-negative patients with NPC treated by IMRT. A further Phase 3 study is warranted. Based on the results of this first Phase 2 study, we suggest omitting ENI to Level IB in Ib-negative patients with NPC with extensive nodal disease treated by IMRT.

  9. Rise and dissemination of aminoglycoside resistance: the aac(6'-Ib paradigm

    Directory of Open Access Journals (Sweden)

    María Soledad eRamirez

    2013-05-01

    Full Text Available Enzymatic modification is a prevalent mechanism by which bacteria defeat the action of antibiotics. Aminoglycosides are often inactivated by aminoglycoside modifying enzymes encoded by genes present in the chromosome, plasmids, and other genetic elements. The AAC(6’-Ib (aminoglycoside 6’-N-acetyltransferase type Ib is an enzyme of clinical importance found in a wide variety of gram-negative pathogens. The AAC(6’-Ib enzyme is of interest not only because of his ubiquity but also because of other characteristics, it presents significant microheterogeneity at the N-termini and the aac(6’-Ib gene is often present in integrons, transposons, plasmids, genomic islands, and other genetic structures. Excluding the highly heterogeneous N-termini, there are 45 non-identical AAC(6’-Ib related entries in the NCBI database, 32 of which have identical name in spite of not having identical amino acid sequence. While some variants conserved similar properties, others show dramatic differences in specificity, including the case of AAC(6’-Ib-cr that mediates acetylation of ciprofloxacin representing a rare case where a resistance enzyme acquires the ability to utilize an antibiotic of a different class as substrate. Efforts to utilize antisense technologies to turn off expression of the gene or to identify enzymatic inhibitors to induce phenotypic conversion to susceptibility are under way.

  10. Critical Success Factors for Lean Thinking in the Application of Industrialised Building System (IBS)

    Science.gov (United States)

    Yunus, Riduan; Noor, Siti Rahimah Mohd; Halid Abdullah, Abd; Nagapan, Sasitharan; Hamid, Abdul Rahim Abdul; Tajudin, Saiful Azhar Ahmad; Rohani Mat Jusof, Siti

    2017-08-01

    Productivity in the manufacturing process of building components can be increased by optimising each advantage that is available in each activity. Identification of critical success factors (CSFs) for lean thinking in the Industrialised Building System (IBS) will be able to minimise cost and reduce time needed to complete a project. The focus of lean thinking in construction is on the production process and the client’s requirement. In developing countries such as Malaysia, the integration of lean thinking in IBS applications is still low and there is a shortage of comprehensive strategies to integrate lean thinking. As key stakeholders, feedback from contractors, manufacturers, developers and the local authority will be able to help the identification of CSFs in integrating lean thinking in IBS applications. The data was collected through a questionnaire survey and analysed quantitatively. There are 31 CSFs for lean thinking in IBS which have been identified in this study. A conceptual model was developed to assist researchers in investigating the influences of CSFs for lean thinking in IBS applications. This study will assist construction players to improvise their manufacturing process in the implementation of IBS to eliminate unnecessary activities and focus instead on significant processes without generating physical and non-physical waste.

  11. Systematic review of diagnostic criteria for IBS demonstrates poor validity and utilization of Rome III.

    Science.gov (United States)

    Dang, J; Ardila-Hani, A; Amichai, M M; Chua, K; Pimentel, M

    2012-09-01

    In the absence of a clear biomarker for irritable bowel syndrome (IBS), clinical criteria are used. In this study, we conduct a systematic review to examine the validation and utilization of IBS criteria. A systematic review was performed in two stages. The first was a review of literature from 1978 validating IBS diagnostic criteria. The second stage of review was to select studies published in IBS between 1992 and 2011. This time period was divided into three segments (Rome I era from 1992 to 1999, Rome II era from 2000 to 2006, and Rome III era from 2007 to 2011). The number and type of study (RCT or other) and criteria used were evaluated for each era. The first stage of the systematic review identified only 14 published studies validating diagnostic tests for IBS (with three studies evaluating more than one criterion). There were eight validations for Manning, three validations for Kruis, four validations for Rome I, three validations for Rome II, and no validation for Rome III. In the second review of utilization of Rome criteria, only 25.7% of published IBS papers used Rome III criteria during the Rome III era (Rome II was used most in 64.8% of studies). This review identified that comparator groups varied widely between studies making comparison of criteria impossible. Manning criteria are the most valid and accurate criteria. More importantly, Rome III is not validated and is poorly adopted in clinical research trial enrollment. © 2012 Blackwell Publishing Ltd.

  12. A Preliminary Review on Economies of Scale (EOS Towards Industrialized Building System (IBS Manufacturer

    Directory of Open Access Journals (Sweden)

    Tajul Ariffin Syazwana

    2017-01-01

    Full Text Available Industrialized Building System (IBS is a potential technology to improve productivity of construction industry. Controlled production and minimum generation of construction waste are some of the benefits that can be achieved by replacing conventional construction with IBS. In business, IBS is giving a huge opportunity for manufacturer and supplier to expand their business while contributing to construction development. However, bad strategies will put the company in high risk due to higher initial capital for machines and equipment. Therefore, strategic planning for company’s growth, profit maximization, and enhancement of productivity is undeniable to ensure the success of business in construction industry. This preliminary paper is exploring associated factors that affect Economy of Scale (EOS and their relationships in catalyzing the IBS manufacturer especially precast concrete as the scope of study to continue their business in the construction industry. Thus, a framework of EOS is proposed to assist IBS manufacturers to ensure their company’s growth and stability, competitiveness in term of monopoly or an oligopoly, increasing productivity, leading constant returns to scale, and finally increasing the firm’s efficiency. The refined EOS’s conceptual framework is an important turning point to support the development of decision making tools for IBS manufacturer towards their stability and survival in this highly competitive industry.

  13. Phenotyping of subjects for large scale studies on patients with IBS.

    Science.gov (United States)

    Boeckxstaens, G E; Drug, V; Dumitrascu, D; Farmer, A D; Hammer, J; Hausken, T; Niesler, B; Pohl, D; Pojskic, L; Polster, A; Simren, M; Goebel-Stengel, M; Van Oudenhove, L; Vassallo, M; Wensaas, K-A; Aziz, Q; Houghton, L A

    2016-08-01

    Irritable bowel syndrome (IBS) is a complex condition with multiple factors contributing to its aetiology and pathophysiology. Aetiologically these include genetics, life-time events and environment, and physiologically, changes in motility, central processing, visceral sensitivity, immunity, epithelial permeability and gastrointestinal microflora. Such complexity means there is currently no specific reliable biomarker for IBS, and thus IBS continues to be diagnosed and classified according to symptom based criteria, the Rome Criteria. Carefully phenotyping and characterisation of a 'large' pool of IBS patients across Europe and even the world however, might help identify sub-populations with accuracy and consistency. This will not only aid future research but improve tailoring of treatment and health care of IBS patients. The aim of this position paper is to discuss the requirements necessary to standardize the process of selecting and phenotyping IBS patients and how to organise the collection and storage of patient information/samples in such a large multi-centre pan European/global study. We include information on general demographics, gastrointestinal symptom assessment, psychological factors, quality of life, physiological evaluation, genetic/epigenetic and microbiota analysis, biopsy/blood sampling, together with discussion on the organisational, ethical and language issues associated with implementing such a study. The proposed approach and documents selected to be used in such a study was the result of a thoughtful and thorough four-year dialogue amongst experts associated with the European COST action BM1106 GENIEUR (www.GENIEUR.eu). © 2016 John Wiley & Sons Ltd.

  14. The broad line type Ic supernova SN 2007ru: Adding to the diversity of type Ic supernovae

    CERN Document Server

    Sahu, D K; Anupama, G C; Gurugubelli, Uday K; Nomoto, Ken'ichi

    2008-01-01

    Photometric and spectral evolution of the type Ic supernova SN 2007ru during the first 3 months are presented. The spectra show broad spectral features due to very high expansion velocity, normally seen in hypernovae. The photospheric velocity is higher than other type Ic supernovae. It is lower than SN 1998bw at $\\sim$ 8 days after the explosion, but is comparable at later epochs. The light curve evolution of SN 2007ru indicates a fast rise time of 8$\\pm$3 days to $B$ band maximum and post-maximum decline more rapidly than other broad-line type Ic supernovae.With an absolute $V$ magnitude of -19.10, SN 2007ru is comparable in brightness with SN 1998bw and lies at the brighter end of the observed type Ic supernovae. The mass of \\Nifs is estimated to be $\\sim 0.4\\Msun$. The fast rise and decline of the light curve and the high expansion velocity suggest that SN 2007ru is an explosion with a high kinetic energy/ejecta mass ratio ($E_{\\rm K}/M_{\\rm {ej}}$). This adds to the diversity of type Ic supernovae.

  15. Extreme low-power mixed signal IC design

    CERN Document Server

    Tajalli, Armin

    2010-01-01

    This book describes a completely novel class of techniques for designing ultra-low-power integrated circuits (ICs). In many applications such as battery operated systems and battery-less (energy-scavenging) systems, power dissipation is a critical parameter. As a result, there is a growing demand for reducing the power (energy) consumption in ICs to extremely low levels, not achievable by using classical ""subthreshold CMOS"" techniques. This book introduces a new family of ""subthreshold circuits"" called ""source-coupled circuits"". This family of circuits can be used for implementing digita

  16. JOULE HEATING INDUCED INTERCONNECT FAILURE IN 3D IC TECHNOLOGY

    OpenAIRE

    Li, Menglu

    2016-01-01

    With the slow-down of Moore’s law of scaling transistors, the industry is looking for 3D IC technology to extend the Moore’s law by stacking chips vertically. In the 3D IC technology, Joule heating is the most serious reliability concern because of increased power density. Moreover, there are new interconnects in the package to support vertical stacking, including the Through Silicon Via (TSV) inside silicon die, μ-bumps between different dies, and redistribution layer (RDL) to fan out the cu...

  17. Dicty_cDB: FC-IC0430 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC0430 (Link to dictyBase) - - - Contig-U16271-1 FC-IC04... (Link to library) Clone ID FC-IC0430 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link t...o Contig Contig-U16271-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...ology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC0430 (FC-IC...l 4.0 %: mitochondrial 4.0 %: endoplasmic reticulum >> prediction for FC-IC0430 is cyt 5' end seq. ID FC-IC0430F 5' end seq. >FC-IC

  18. Dicty_cDB: FC-IC0649 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC0649 (Link to dictyBase) - - - Contig-U16566-1 FC-IC06...ink to library) Clone ID FC-IC0649 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Co...ntig-U16566-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC... Score E Sequences producing significant alignments: (bits) Value FC-IC0649 (FC-IC0649Q) /CSM/FC-IC/FC-IC064...ory system 4.0 %: cytoskeletal 4.0 %: vacuolar 4.0 %: Golgi 4.0 %: mitochondrial >> prediction for FC-IC0649

  19. Dicty_cDB: FC-IC0993 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC0993 (Link to dictyBase) - G24303 DDB0220699 Contig-U08379-1 FC-IC... (Link to library) Clone ID FC-IC0993 (Link to dictyBase) Atlas ID - NBRP ID G24303 dic...gi 4.0 %: plasma membrane 4.0 %: vesicles of secretory system 4.0 %: extracellular, including cell wall >> prediction for FC-IC...0993E (Link to Original site) FC-IC0993F 526 FC-IC0993Z 526 FC-IC0993P 1032 FC-IC0993E 516 Show FC-IC0993 Library FC-IC...tyBase ID DDB0220699 Link to Contig Contig-U08379-1 Original site URL http://dic

  20. Dicty_cDB: FC-IC0027 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC0027 (Link to dictyBase) - - - Contig-U08312-1 FC-IC00...27F (Link to Original site) FC-IC0027F 578 - - - - - - Show FC-IC0027 Library FC-IC (Link to library) Clone ID FC-IC...0005Q) /CSM/FC-IC/FC-IC0005Q.Seq.d/ 531 e-150 own update 2001.11.18 Homology vs DNA Score E Sequences producing signific...les of secretory system 4.0 %: endoplasmic reticulum >> prediction for FC-IC0027 is nuc 5' end seq. ID FC-IC...0027 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Contig-U08312-1 Original site URL http://dic

  1. Dicty_cDB: FC-IC0758 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC0758 (Link to dictyBase) - - - Contig-U07877-1 FC-IC07...ink to library) Clone ID FC-IC0758 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Co...ntig-U07877-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...cldr Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC0758 (FC-IC0758Q) /CSM/FC-IC/FC-IC...0 %: mitochondrial 4.0 %: plasma membrane 4.0 %: vesicles of secretory system >> prediction for FC-IC

  2. Dicty_cDB: FC-IC1440 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1440 (Link to dictyBase) - - - Contig-U15453-1 FC-IC14... (Link to library) Clone ID FC-IC1440 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link t...o Contig Contig-U15453-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...re E Sequences producing significant alignments: (bits) Value FC-IC1440 (FC-IC1440Q) /CSM/FC-IC/FC-IC...clear 36.0 %: cytoplasmic 8.0 %: cytoskeletal 8.0 %: mitochondrial 4.0 %: vacuolar >> prediction for FC-IC14

  3. Dicty_cDB: FC-IC0501 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC0501 (Link to dictyBase) - - - Contig-U16382-1 FC-IC05... (Link to library) Clone ID FC-IC0501 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link t...o Contig Contig-U16382-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...y vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC0501 (FC-IC...les of secretory system >> prediction for FC-IC0501 is nuc 5' end seq. ID FC-IC0501F 5' end seq. >FC-IC

  4. Dicty_cDB: FC-IC0954 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC0954 (Link to dictyBase) - - - Contig-U16382-1 FC-IC09... (Link to library) Clone ID FC-IC0954 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link t...o Contig Contig-U16382-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...SM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC0954 (FC-IC0954Q) /CSM/FC-IC/FC-IC.../FC-IC1696Q.Seq.d/ 761 0.0 own update 2004.12.25 Homology vs DNA Score E Sequences producing signific

  5. Dicty_cDB: FC-IC1149 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1149 (Link to dictyBase) - - - Contig-U16271-1 - (Link to Original site) FC-IC...1149F 272 - - - - - - Show FC-IC1149 Library FC-IC (Link to library) Clone ID FC-IC1149 (Link to dic...tyostelium discoideum gamete cDNA clone:FC-IC1... 519 e-143 1 ( AU272187 ) Dictyostelium discoideu...m gamete cDNA clone:FC-IC1... 519 e-143 1 ( AU272185 ) Dictyostelium discoideum gamete cDNA clone:FC-IC1... ...elium discoideum gamete cDNA clone:FC-IC1... 517 e-143 1 ( AU275192 ) Dictyostelium discoideum gamete cDNA clone:FC-IC

  6. Dicty_cDB: FC-IC1236 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1236 (Link to dictyBase) - - - Contig-U12406-1 - (Link... to Original site) - - FC-IC1236Z 497 - - - - Show FC-IC1236 Library FC-IC (Link to library) Clone ID FC-IC1236 (Link to dic...xxxlvxslcfxw Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC1236 (FC-IC1236Q) /CSM/FC-IC...tyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Contig-U12406-1 Original site URL http://dic...tycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC1236Q.Seq.d/ Representative se

  7. Dicty_cDB: FC-IC0067 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC0067 (Link to dictyBase) - - - Contig-U16382-1 FC-IC00...67F (Link to Original site) FC-IC0067F 267 - - - - - - Show FC-IC0067 Library FC-IC (Link to library) Clone ID FC-IC...tochondrial 8.0 %: Golgi 4.0 %: vesicles of secretory system 4.0 %: endoplasmic reticulum >> prediction for FC-IC...0067 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Contig-U16382-1 Original site URL http://dic...tycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC0067Q.Seq.d/ Representative seq. ID FC-IC

  8. Dicty_cDB: FC-IC0162 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC0162 (Link to dictyBase) - - - Contig-U10099-1 FC-IC01...62F (Link to Original site) FC-IC0162F 358 - - - - - - Show FC-IC0162 Library FC-IC (Link to library) Clone ID FC-IC...DGPDDEALPVVDGPDDEALP-- - Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC0162 (FC-IC...%: cytoskeletal 4.0 %: Golgi 4.0 %: cytoplasmic >> prediction for FC-IC0162 is end 5' end seq. ID FC-IC...0162 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Contig-U10099-1 Original site URL http://dic

  9. Dicty_cDB: FC-IC1178 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1178 (Link to dictyBase) - - - Contig-U16026-1 - (Link... to Original site) - - FC-IC1178Z 442 - - - - Show FC-IC1178 Library FC-IC (Link to library) Clone ID FC-IC1178 (Link to dic... vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC1178 (FC-IC1178Q) /CSM/FC-IC/FC-IC...les of secretory system >> prediction for FC-IC1178 is end 5' end seq. ID - 5' end seq. - Length ...tyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Contig-U16026-1 Original site URL http://dic

  10. Supernova 2008J: early time observations of a heavily reddened SN 2002ic-like transient

    DEFF Research Database (Denmark)

    Taddia, F.; Stritzinger, M. D.; Phillips, M. M.

    2012-01-01

    Aims: We provide additional observational evidence that some Type Ia supernovae (SNe Ia) show signatures of circumstellar interaction (CSI) with hydrogen-rich material. Methods: Early phase optical and near-infrared (NIR) light curves and spectroscopy of SN 2008J obtained by the Carnegie Supernov...

  11. Supernova 2008J: early time observations of a heavily reddened SN 2002ic-like transient

    DEFF Research Database (Denmark)

    Taddia, F.; Stritzinger, M. D.; Phillips, M. M.;

    2012-01-01

    Aims: We provide additional observational evidence that some Type Ia supernovae (SNe Ia) show signatures of circumstellar interaction (CSI) with hydrogen-rich material. Methods: Early phase optical and near-infrared (NIR) light curves and spectroscopy of SN 2008J obtained by the Carnegie Supernov...

  12. ICS-UNIDO - Promoting sustainable POPs disposal and remediation technologies

    Energy Technology Data Exchange (ETDEWEB)

    Zinovyev, S.; Lodolo, A.; Miertus, S. [ICS-UNIDO, Trieste (Italy)

    2004-09-15

    It is well known that a significant stock of polychlorinated hazards, including POP and PTS, has been produced and is stored nowadays or dispersed in the environment in many of Developing Countries and Countries with Economies in Transition. The obsolete industrial processes, giving rise to formation of dioxins, as well as former/current POP production/use (e.g. PCBs), coupled with uncontrolled use of polychlorinated pesticides in agriculture and improper storage of POP stockpiles have rendered vast territories in these countries highly contaminated and raised urgent issues of disposal of hazards and remediation of territories. The International Centre for Science and High Technology (ICS), www.ics.trieste.it, is an autonomous institution within the legal framework of the United Nations Industrial Development Organization (UNIDO) promoting a global programme on environmental protection, sustainable chemistry, catalysis, and clean technologies. An important part of its work programme is focused on the promotion of new technologies which can be helpful for the reduction of the formation of POPs (like dioxins and furans) in incineration processes and in obsolete technologies used in some industrial processes. Another hot issue is to promote safe technologies for the destruction of PCBs and polychlorinated pesticides. Particular efforts of ICS-UNIDO are directed towards the transfer of clean technologies to developing/transition countries. ICS-UNIDO, through its initiatives, seeks to establish a dialogue with local administrative, research, NGO, and industrial bodies in order to adopt sustainable technologies for POP disposal and management of contaminated sites.

  13. A deep multi-band investigation of IC2391

    CERN Document Server

    Spezzi, L; Marino, G; Leto, G; Young, E; Siegler, N; Balog, Z; Messina, S; Distefano, E; Merin, B; Navascues, D Barrado y

    2009-01-01

    We report the outcome of a deep multi-wavelength study of the IC2391 young open cluster. We aim at uncovering new low-mass and sub-stellar members of the cluster and identifying new debris disk objects. A 30*30 square arcmin area in IC 2391 was observed using the wide-field imager at the ESO 2.2m telescope. The completeness limits of the photometry at 3 sigma level are V=24.7, Rc=23.7 and Ic=23.0, faint enough to reveal sub-stellar members down to about 0.03 solar masses. Our membership criteria are based on the use of our optical data, in combination with JHKs magnitudes from the 2MASS catalog. We also estimate the physical parameters of the selected candidates. Debris disk candidates are identified on the basis of their infrared excess emission using near- and mid-infrared photometry from the Spitzer Space Telescope. Our optical survey, which has a limiting magnitude at 3 sigma level 1-2 mag fainter than previous optical surveys conducted in IC2391, revealed 29 new low-mass member candidates of the cluster....

  14. IC 5063 : AGN driven outflow of warm and cold gas

    NARCIS (Netherlands)

    Morganti, R.; Holt, J.; Saripalli, L.; Oosterloo, T. A.; Tadhunter, C. N.

    2007-01-01

    We present new ATCA 17- and 24- GHz radio images and ESO- NTT optical spectra of the radio- loud Seyfert galaxy IC 5063, the first galaxy in which a fast (similar to 600 km s(-1)) outflow of neutral hydrogen was discovered. The new radio data confirm the triple radio structure with a central, unreso

  15. Development of an ASD IC for the Micro Pixel Chamber

    CERN Document Server

    Orito, R; Kubo, H; Miuchi, K; Nagayoshi, T; Okada, Y; Takada, A; Takeda, A; Tanimori, T; Ueno, M

    2004-01-01

    A new amplifier-shaper-discriminator (ASD) chip was designed and manufactured for the Micro Pixel Chamber ($\\mu$-PIC). The design of this ASD IC is based on the ASD IC (TGC-ASD) for the Thin Gap Chamber in the LHC Atlas Experiment. The decay time constant of the preamplifier is 5-times longer than that of the TGC-ASD, and some other modifications have been made in order to improve the signal-to-noise ratio of the $\\mu$-PIC. The ASD IC uses SONY Analog Master Slice bipolar technology. The IC contains 4 channels in a QFP48 package. The decay time constant of the preamplifier is 80 ns and its gain is approximately 0.8 V/pC. The output from the preamplifier is received by a shaper (main-amplifier) with a gain of 7. A baseline restoration circuit is incorporated in the main-amplifier, and the current used for the baseline restoration is 5-times smaller than that of the TGC-ASD. The threshold voltage for the discriminator section is common to the 4 channels and their digital output level is LVDS-compatible. The ASD...

  16. How to write an ICS/IUGA conference abstract.

    NARCIS (Netherlands)

    Cartwright, R.; Tikkinen, K.A.; Vierhout, M.E.; Koelbl, H.

    2010-01-01

    INTRODUCTION: This article aims to condense the lectures and discussions from workshops on good reporting at IUGA Como 2009 and ICS San Francisco 2009, providing practical advice for the novice researcher summarising their data for the first time. CONCLUSIONS: Drafting an abstract can be a time cons

  17. Local IC Market:Not Made in China

    Institute of Scientific and Technical Information of China (English)

    HAYET SELLAMI

    2006-01-01

    @@ Ranking first in the world's integrated circuits (IC) market with a value of US$40.8 billion, China is becoming the Silicon Valley of the East as overseas investors compete to establish companies and factories to assemble or design chips for cell phones, computers and any other type of electronic device.

  18. Analog IC Design at the University of Twente

    NARCIS (Netherlands)

    Nauta, Bram

    2007-01-01

    This article describes some recent research results from the IC Design group of the University of Twente, located in Enschede, The Netherlands. Our research focuses on analog CMOS circuit design with emphasis on high frequency and broadband circuits. With the trend of system integration in mind, we

  19. Validating the Implementation Climate Scale (ICS) in child welfare organizations.

    Science.gov (United States)

    Ehrhart, Mark G; Torres, Elisa M; Wright, Lisa A; Martinez, Sandra Y; Aarons, Gregory A

    2016-03-01

    There is increasing emphasis on the use of evidence-based practices (EBPs) in child welfare settings and growing recognition of the importance of the organizational environment, and the organization's climate in particular, for how employees perceive and support EBP implementation. Recently, Ehrhart, Aarons, and Farahnak (2014) reported on the development and validation of a measure of EBP implementation climate, the Implementation Climate Scale (ICS), in a sample of mental health clinicians. The ICS consists of 18 items and measures six critical dimensions of implementation climate: focus on EBP, educational support for EBP, recognition for EBP, rewards for EBP, selection or EBP, and selection for openness. The goal of the current study is to extend this work by providing evidence for the factor structure, reliability, and validity of the ICS in a sample of child welfare service providers. Survey data were collected from 215 child welfare providers across three states, 12 organizations, and 43 teams. Confirmatory factor analysis demonstrated good fit to the six-factor model and the alpha reliabilities for the overall measure and its subscales was acceptable. In addition, there was general support for the invariance of the factor structure across the child welfare and mental health sectors. In conclusion, this study provides evidence for the factor structure, reliability, and validity of the ICS measure for use in child welfare service organizations.

  20. Revealing Hanny's Voorwerp : radio observations of IC 2497

    NARCIS (Netherlands)

    Jozsa, G. I. G.; Garrett, M. A.; Oosterloo, T. A.; Rampadarath, H.; Paragi, Z.; van Arkel, H.; Lintott, C.; Keel, W. C.; Schawinski, K.; Edmondson, E.

    2009-01-01

    We present multi-wavelength radio observations in the direction of the spiral galaxy IC 2497 and the neighbouring emission nebula known as "Hanny's Voorwerp". Our WSRT continuum observations at 1.4 GHz and 4.9 GHz reveal the presence of extended emission at the position of the nebulosity, although t

  1. Saturn V Stage I (S-IC) Overview

    Science.gov (United States)

    Interbartolo, Michael

    2009-01-01

    Objectives include: a) Become familiar with the Saturn V Stage I (S-IC) major structural components: Forward Skirt, Oxidizer Tank, Intertank, Fuel Tank, and Thrust Structure. b) Gain a general understanding of the Stage I subsystems: Fuel, Oxidizer, Instrumentation, Flight Control, Environmental Control, Electrical, Control Pressure, and Ordinance.

  2. Testing Cosmological Models with Type Ic Super Luminous Supernovae

    CERN Document Server

    Wei, Jun-Jie; Melia, Fulvio

    2015-01-01

    The use of type Ic Super Luminous Supernovae (SLSN Ic) to examine the cosmological expansion introduces a new standard ruler with which to test theoretical models. The sample suitable for this kind of work now includes 11 SLSNe Ic, which have thus far been used solely in tests involving $\\Lambda$CDM. In this paper, we broaden the base of support for this new, important cosmic probe by using these observations to carry out a one-on-one comparison between the $R_{\\rm h}=ct$ and $\\Lambda$CDM cosmologies. We individually optimize the parameters in each cosmological model by minimizing the $\\chi^{2}$ statistic. We also carry out Monte Carlo simulations based on these current SLSN Ic measurements to estimate how large the sample would have to be in order to rule out either model at a $\\sim 99.7\\%$ confidence level. The currently available sample indicates a likelihood of $\\sim$$70-80\\%$ that the $R_{\\rm h}=ct$ Universe is the correct cosmology versus $\\sim$$20-30\\%$ for the standard model. These results are suggest...

  3. Spectral measurement using IC-compatible linear variable optical filter

    NARCIS (Netherlands)

    Emadi, A.; Grabarnik, S.; Wu, H.; De Graaf, G.; Hedsten, K.; Enoksson, P.; Correia, J.H.; Wolffenbuttel, R.F.

    2010-01-01

    This paper reports on the functional and spectral characterization of a microspectrometer based on a CMOS detector array covered by an IC-Compatible Linear Variable Optical Filter (LVOF). The Fabry-Perot LVOF is composed of 15 dielectric layers with a tapered middle cavity layer, which has been

  4. ASKAP HI imaging of the galaxy group IC 1459

    CERN Document Server

    Serra, P; Kilborn, V; Allison, J R; Amy, S W; Ball, L; Bannister, K; Bell, M E; Bock, D C -J; Bolton, R; Bowen, M; Boyle, B; Broadhurst, S; Brodrick, D; Brothers, M; Bunton, J D; Chapman, J; Cheng, W; Chippendale, A P; Chung, Y; Cooray, F; Cornwell, T; DeBoer, D; Diamond, P; Forsyth, R; Gough, R; Gupta, N; Hampson, G A; Harvey-Smith, L; Hay, S; Hayman, D B; Heywood, I; Hotan, A W; Hoyle, S; Humphreys, B; Indermuehle, B; Jacka, C; Jackson, C A; Jackson, S; Jeganathan, K; Johnston, S; Joseph, J; Kamphuis, P; Leach, M; Lenc, E; Lensson, E; Mackay, S; Marquarding, M; Marvil, J; McClure-Griffiths, N; McConnell, D; Meyer, M; Mirtschin, P; Neuhold, S; Ng, A; Norris, R P; O'Sullivan, J; Pathikulangara, J; Pearce, S; Phillips, C; Popping, A; Qiao, R Y; Reynolds, J E; Roberts, P; Sault, R J; Schinckel, A E T; Shaw, R; Shimwell, T W; Staveley-Smith, L; Storey, M; Sweetnam, A W; Troup, E; Tzioumis, A; Voronkov, M A; Westmeier, T; Whiting, M; Wilson, C; Wong, O I; Wu, X

    2015-01-01

    We present HI imaging of the galaxy group IC 1459 carried out with six antennas of the Australian SKA Pathfinder equipped with phased-array feeds. We detect and resolve HI in eleven galaxies down to a column density of $\\sim10^{20}$ cm$^{-2}$ inside a ~6 deg$^2$ field and with a resolution of ~1 arcmin on the sky and ~8 km/s in velocity. We present HI images, velocity fields and integrated spectra of all detections, and highlight the discovery of three HI clouds -- two in the proximity of the galaxy IC 5270 and one close to NGC 7418. Each cloud has an HI mass of $10^9$ M$_\\odot$ and accounts for ~15% of the HI associated with its host galaxy. Available images at ultraviolet, optical and infrared wavelengths do not reveal any clear stellar counterpart of any of the clouds, suggesting that they are not gas-rich dwarf neighbours of IC 5270 and NGC 7418. Using Parkes data we find evidence of additional extended, low-column-density HI emission around IC 5270, indicating that the clouds are the tip of the iceberg o...

  5. The craftsmanship of the "Carolingian" astrolabe, IC 3042.

    Science.gov (United States)

    L'E. Turner, G.

    The medieval astrolabe (IC 3042) once owned by the late Marcel Destombes and published by him in 1962, has been examined to discover as many details of the craftsmanship as possible. The conclusion is that the astrolabe was not made by a craftsman, but more likely by a scholar for his own use.

  6. Analog IC Design at the University of Twente

    NARCIS (Netherlands)

    Nauta, Bram

    2007-01-01

    This article describes some recent research results from the IC Design group of the University of Twente, located in Enschede, The Netherlands. Our research focuses on analog CMOS circuit design with emphasis on high frequency and broadband circuits. With the trend of system integration in mind, we

  7. A combined BEM/FEM method for IC substrate modeling

    NARCIS (Netherlands)

    Schrik, E.

    2006-01-01

    The research presented in this thesis was done in the context of the modeling of parasitic physical effects, like field couplings and crosstalk, that may adversely affect the functional performance of Integrated Circuits (ICs). The modeling of parasitic effects, through simulations with the resultin

  8. Revealing Hanny's Voorwerp : radio observations of IC 2497

    NARCIS (Netherlands)

    Jozsa, G. I. G.; Garrett, M. A.; Oosterloo, T. A.; Rampadarath, H.; Paragi, Z.; van Arkel, H.; Lintott, C.; Keel, W. C.; Schawinski, K.; Edmondson, E.

    We present multi-wavelength radio observations in the direction of the spiral galaxy IC 2497 and the neighbouring emission nebula known as "Hanny's Voorwerp". Our WSRT continuum observations at 1.4 GHz and 4.9 GHz reveal the presence of extended emission at the position of the nebulosity, although

  9. Effect of Electroacupuncture on Chronic Visceral Pain and Involvement of Spinal NMDA Receptor in IBS Rats

    Institute of Scientific and Technical Information of China (English)

    王智君; 李为民; 周娟; 陈颖波

    2009-01-01

    Objective:To clarify effect of electroacupuncture (EA) on relieving chronic visceral pain and the underlying neurobiological mechanism for such an effect,we observed the effect of EA on the Irritable bowel syndrome (IBS) rat and then examined spinal expression of N-methyl-D-aspartate (NMDA)receptor-1 in rats.Methods:Daily mechanical colon distention was performed on male Sprague-Dawley neonatal rats to produce IBS model.EA was applied at acupoints of Zusanli (ST 36) and Shangjuxu (ST 37)in each hind leg.Abdominal withdrawal reflex (AWR) assessment or rectus abdominis electromyograms (AEMG) recordings were then performed after EA treatment.The mRNA expression of the NMDA subtype of glutamate receptors in the spinal dorsal horn (L4-5) before and after EA was investigated by RT-PCR analysis in IBS rats.Results:The results demonstrated that EA could significantly decreased both AWR scores from behavioral test and AEMG discharges from electrophysiological recording in IBS model rats elicited by colorectal distension (CRD) stimuli with strengths of 20,40,60 and 80 mmHg,respectively (P<0.05).Meanwhile there was a significant decrease in mRNA expression of NMDA receptor-1 in the spinal dorsal horn of IBS rats treated by EA (P<0.05),but no such effect was observed in IBS rats treated by sham EA (inserting needles without electrical stimulation).Conclusion:These results indicate that EA can relieve chronic visceral hyperalgesia in IBS rats and this effect might be correlated with the down-regulation of NMDA receptor-1 in the dorsal hom of the spinal cord.

  10. Effect of Electroacupuncture on Chronic Visceral Pain and Involvement of Spinal NMDA Receptor in IBS Rats

    Institute of Scientific and Technical Information of China (English)

    王智君; 李为民; 周娟; 陈颖波

    2008-01-01

    Objective: To clarify effect of electroacupuncture (EA) on relieving chronic visceral pain and the underlying neurobiological mechanism for such an effect, we observed the effect of EA on the Irritable bowel syndrome (IBS) rat and then examined spinal expression of N-methyl-D-aspartate (NMDA) receptor-1 in rats. Methods: Daily mechanical colon distention was performed on male Sprague-Dawley neonatal rats to produce IBS model. EA was applied at acupoints of Zusanli (ST 36) and Shangjuxu (ST 37) in each hind leg. Abdominal withdrawal reflex (AWR) assessment or rectus abdominis electromyograms (AEMG) recordings were then performed after EA treatment. The mRNA expression of the NMDA subtype of glutamate receptors in the spinal dorsal horn (L4-5) before and after EA was investigated by RT-PCR analysis in IBS rats. Results: The results demonstrated that EA could significantly decreased both AWR scores from behavioral test and AEMG discharges from electrophysiological recording in IBS model rats elicited by colorectal distension (CRD) stimuli with strengths of 20, 40, 60 and 80 mmHg, respectively (P<0.05). Meanwhile there was a significant decrease in mRNA expression of NMDA receptor-1 in the spinal dorsal horn of IBS rats treated by EA (P<0.05), but no such effect was observed in IBS rats treated by sham EA (inserting needles without electrical stimulation). Conclusion: These results indicate that EA can relieve chronic visceral hyperalgesia in IBS rats and this effect might be correlated with the down-regulation of NMDA receptor- 1 in the dorsal horn of the spinal cord.

  11. Sensitivity to wheat, gluten and FODMAPs in IBS: facts or fiction?

    Science.gov (United States)

    De Giorgio, Roberto; Volta, Umberto; Gibson, Peter R

    2016-01-01

    IBS is one of the most common types of functional bowel disorder. Increasing attention has been paid to the causative role of food in IBS. Food ingestion precipitates or exacerbates symptoms, such as abdominal pain and bloating in patients with IBS through different hypothesised mechanisms including immune and mast cell activation, mechanoreceptor stimulation and chemosensory activation. Wheat is regarded as one of the most relevant IBS triggers, although which component(s) of this cereal is/are involved remain(s) unknown. Gluten, other wheat proteins, for example, amylase-trypsin inhibitors, and fructans (the latter belonging to fermentable oligo-di-mono-saccharides and polyols (FODMAPs)), have been identified as possible factors for symptom generation/exacerbation. This uncertainty on the true culprit(s) opened a scenario of semantic definitions favoured by the discordant results of double-blind placebo-controlled trials, which have generated various terms ranging from non-coeliac gluten sensitivity to the broader one of non-coeliac wheat or wheat protein sensitivity or, even, FODMAP sensitivity. The role of FODMAPs in eliciting the clinical picture of IBS goes further since these short-chain carbohydrates are found in many other dietary components, including vegetables and fruits. In this review, we assessed current literature in order to unravel whether gluten/wheat/FODMAP sensitivity represent 'facts' and not 'fiction' in IBS symptoms. This knowledge is expected to promote standardisation in dietary strategies (gluten/wheat-free and low FODMAP) as effective measures for the management of IBS symptoms. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  12. Blastocystis specific serum immunoglobulin in patients with irritable bowel syndrome (IBS) versus healthy controls.

    Science.gov (United States)

    Nagel, Robyn; Traub, Rebecca J; Kwan, Marcella M S; Bielefeldt-Ohmann, Helle

    2015-09-15

    Blastocystis species are common enteric human parasites and carriage has been linked to Irritable Bowel Syndrome (IBS), particularly diarrhoea-predominant IBS. The spectrum of immune reactivity to Blastocystis proteins has been reported previously in symptomatic patients. We investigated differences in serum immunoglobulin profiles between patients with IBS, both positive and negative for Blastocystis carriage, and healthy controls (HC). Forty diarrhoea-predominant IBS patients (26 patients positive for Blastocystis sp., 14 negative patients) and forty HC (24 positive, 16 Blastocystis-negative) were enrolled. Age, gender, ethnicity and serum immunoglobulin A (IgA) levels were recorded and faecal specimens were analysed using smear, culture and polymerase chain reaction amplification of ribosomal DNA. Sera were tested in Western blots and the reactivities compared to known targets using monoclonal antibodies Blastofluor® (Blastocystis specific antibody), MAb1D5 (cytopathicto Blastocystis cells), anti-promatrix metalloprotease-9 (anti-MMP-9) and SDS-PAGE zymograms. Levels of serum IgA were significantly lower in Blastocystis carriers (p Blastocystis proteins of 17,27,37,50,60-65, 75-90, 95-105 and 150 kDa MW. Reactivity to the 27, 50 and 75-95 kDa proteins were found more frequently in the IBS group compared to the HC's (p Blastocystis-positive IBS patients (p Blastocystis carriage. All IBS patients were more likely to demonstrate reactivity with Blastocystis proteins of 27 kDa (likely a cysteine protease), 50 and 75-95 kDa MW compared to HC. The presence of antibodies to these Blastocystis proteins in some Blastocystis-negative subjects suggests either prior exposure to Blastocystis organisms or antibody cross reactivities. The anti-proMMP-9 reaction at 50 and 75-100 kDa and the zymogram result suggest that metalloproteases may be important Blastocystis antigens. Australian and New Zealand Clinical Trials registry ACTRN: 12611000918921.

  13. A Spitzer Census of the IC 348 Nebula

    Science.gov (United States)

    Muench, August A.; Lada, Charles J.; Luhman, K. L.; Muzerolle, James; Young, Erick

    2007-07-01

    Spitzer mid-infrared surveys enable an accurate census of young stellar objects by sampling large spatial scales, revealing very embedded protostars, and detecting low-luminosity objects. Taking advantage of these capabilities, we present a Spitzer-based census of the IC 348 nebula and embedded star cluster, covering a 2.5 pc region and comparable in extent to the Orion Nebula. Our Spitzer census supplemented with ground-based spectra has added 42 Class II T Tauri sources to the cluster membership and identified ~20 Class 0/I protostars. The population of IC 348 likely exceeds 400 sources after accounting statistically for unidentified diskless members. Our Spitzer census of IC 348 reveals a population of Class I protostars that is anticorrelated spatially with the Class II/III T Tauri members, which comprise the centrally condensed cluster around a B star. The protostars are instead found mostly at the cluster periphery about ~1 pc from the B star and spread out along a filamentary ridge. We further find that the star formation rate in this protostellar ridge is consistent with that rate which built the older exposed cluster, while the presence of 15 cold, starless, millimeter cores intermingled with this protostellar population indicates that the IC 348 nebula has yet to finish forming stars. Moreover, we show that the IC 348 cluster is of order 3-5 crossing times old, and, as evidenced by its smooth radial profile and confirmed mass segregation, is likely relaxed. While it seems apparent that the current cluster configuration is the result of dynamical evolution and its primordial structure has been erased, our finding of a filamentary ridge of Class I protostars supports a model in which embedded clusters are built up from numerous smaller subclusters. Finally, the results of our Spitzer census indicate that the supposition that star formation must progress rapidly in a dark cloud should not preclude these observations that show it can be relatively long lived.

  14. Extensive optical and near-infrared observations of the nearby, narrow-lined type Ic SN 2007gr: days 5 to 415

    CERN Document Server

    Hunter, Deborah J; Kotak, Rubina; Meikle, Peter; Taubenberger, Stefan; Pastorello, Andrea; Benetti, Stefano; Stanishev, Vallery; Smartt, Steven J; Trundle, Carrie; Arkharov, Arkady A; Bufano, Milena; Cappellaro, Enrico; Di Carlo, Elisa; Dolci, Mauro; Elias-Rosa, Nancy; Frandsen, Soeren; Fynbo, Johan U; Hopp, Ulrich; Larionov, Valeri M; Laursen, Peter; Mazzali, Paolo; Navasardyan, Hripsime; Ries, Christoph; Riffeser, Arno; Rizzi, Luca; Tsvetkov, Dmitrii Y; Turatto, Massimo; Wilke, Silona

    2009-01-01

    We present photometric and spectroscopic observations at optical and near-infrared wavelengths of the nearby type Ic SN 2007gr. These represent the most extensive data-set to date of any supernova of this sub-type, with frequent coverage from shortly after discovery to more than one year post-explosion. We deduce a rise time to B-band maximum of 11.5 \\pm 2.7 days. We find a peak B-band magnitude of M_B=-16.8, and light curves which are remarkably similar to the so-called 'hypernova' SN 2002ap. In contrast, the spectra of SNe 2007gr and 2002ap show marked differences, not least in their respective expansion velocities. We attribute these differences primarily to the density profiles of their progenitor stars at the time of explosion i.e. a more compact star for SN 2007gr compared to SN 2002ap. From the quasi-bolometric light curve of SN 2007gr, we estimate that 0.076 $\\pm$ 0.010 Msun of 56Ni was produced in the explosion. Our near-infrared (IR) spectra clearly show the onset and disappearance of the first over...

  15. Intratumoral hu14.18-IL-2 (IC) induces local and systemic antitumor effects that involve both activated T and NK cells as well as enhanced IC retention.

    Science.gov (United States)

    Yang, Richard K; Kalogriopoulos, Nicholas A; Rakhmilevich, Alexander L; Ranheim, Erik A; Seo, Songwon; Kim, Kyungmann; Alderson, Kory L; Gan, Jacek; Reisfeld, Ralph A; Gillies, Stephen D; Hank, Jacquelyn A; Sondel, Paul M

    2012-09-01

    hu14.18-IL-2 (IC) is an immunocytokine consisting of human IL-2 linked to hu14.18 mAb, which recognizes the GD2 disialoganglioside. Phase 2 clinical trials of i.v. hu14.18-IL-2 (i.v.-IC) in neuroblastoma and melanoma are underway and have already demonstrated activity in neuroblastoma. We showed previously that intratumoral hu14.18-IL-2 (IT-IC) results in enhanced antitumor activity in mouse models compared with i.v.-IC. The studies presented in this article were designed to determine the mechanisms involved in this enhanced activity and to support the future clinical testing of intratumoral administration of immunocytokines. Improved survival and inhibition of growth of both local and distant tumors were observed in A/J mice bearing s.c. NXS2 neuroblastomas treated with IT-IC compared with those treated with i.v.-IC or control mice. The local and systemic antitumor effects of IT-IC were inhibited by depletion of NK cells or T cells. IT-IC resulted in increased NKG2D receptors on intratumoral NKG2A/C/E⁺ NKp46⁺ NK cells and NKG2A/C/E⁺ CD8⁺ T cells compared with control mice or mice treated with i.v.-IC. NKG2D levels were augmented more in tumor-infiltrating lymphocytes compared with splenocytes, supporting the localized nature of the intratumoral changes induced by IT-IC treatment. Prolonged retention of IC at the tumor site was seen with IT-IC compared with i.v.-IC. Overall, IT-IC resulted in increased numbers of activated T and NK cells within tumors, better IC retention in the tumor, enhanced inhibition of tumor growth, and improved survival compared with i.v.-IC.

  16. Photoionization of Co$^{+}$ and electron-impact excitation of Co$^{2+}$ using the Dirac R-matrix method

    CERN Document Server

    Tyndall, N B; Ballance, C P; Hibbert, A

    2016-01-01

    Modelling of massive stars and supernovae (SNe) plays a crucial role in understanding galaxies. From this modelling we can derive fundamental constraints on stellar evolution, mass-loss processes, mixing, and the products of nucleosynthesis. Proper account must be taken of all important processes that populate and depopulate the levels (collisional excitation, de-excitation, ionization, recombination, photoionization, bound-bound processes). For the analysis of Type Ia SNe and core collapse SNe (Types Ib, Ic and II) Fe group elements are particularly important. Unfortunately little data is currently available and most noticeably absent are the photoionization cross-sections for the Fe-peaks which have high abundances in SNe. Important interactions for both photoionization and electron-impact excitation are calculated using the relativistic Dirac Atomic $R$-matrix Codes (DARC) for low ionization stages of cobalt. All results are calculated up to photon energies of 45 eV and electron energies up to 20 eV. The w...

  17. LDV+IC5.0在IC设计中的应用%Application of LDV+IC5.0 in IC Design Verification

    Institute of Scientific and Technical Information of China (English)

    王利; 蒋国平; 马幼军

    2005-01-01

    分析LDV+IC5.0仿真工具在混合信号IC设计中的应用以及同Spice仿真工具联合使用来缩短设计周期并保证精度,同时重点分析了模拟硬件电路行为描述语言Verilog-A模型结构并基于verilog和Verilog-A语言实现了数字信号激励, 数模转换器(DAC)的电路模型建立,在Cadence仿真器中实现仿真验证.

  18. Comparison of intraobserver single-task reliabilities of the Interactive Balance System (IBS) and Vertiguard in asymptomatic subjects.

    Science.gov (United States)

    Schwesig, René; Hollstein, Lisa; Plontke, Stefan K; Delank, Karl-Stefan; Fieseler, Georg; Rahne, Torsten

    2017-03-01

    The intraobserver reliabilities of the Interactive Balance System (IBS) and Vertiguard were compared in 30 asymptomatic volunteers. Relative reliability for all IBS single tasks and parameters in the IBS was excellent (intraclass correlation coefficient, ICC ≥0.75). The ICC values ranged from 0.78 to 0.89. The ICC values of the Vertiguard system ranged from 0 to 0.75. The cumulative measure of injury risk of the Vertiguard system was highly reliable.

  19. Enhanced accumulation of carotenoids in sweetpotato plants overexpressing IbOr-Ins gene in purple-fleshed sweetpotato cultivar.

    Science.gov (United States)

    Park, Sung-Chul; Kim, Sun Ha; Park, Seyeon; Lee, Hyeong-Un; Lee, Joon Seol; Park, Woo Sung; Ahn, Mi-Jeong; Kim, Yun-Hee; Jeong, Jae Cheol; Lee, Haeng-Soon; Kwak, Sang-Soo

    2015-01-01

    Sweetpotato [Ipomoea batatas (L.) Lam] is an important root crop that produces low molecular weight antioxidants such as carotenoids and anthocyanin. The sweetpotato orange (IbOr) protein is involved in the accumulation of carotenoids. To increase the levels of carotenoids in the storage roots of sweetpotato, we generated transgenic sweetpotato plants overexpressing IbOr-Ins under the control of the cauliflower mosaic virus (CaMV) 35S promoter in an anthocyanin-rich purple-fleshed cultivar (referred to as IbOr plants). IbOr plants exhibited increased carotenoid levels (up to 7-fold) in their storage roots compared to wild type (WT) plants, as revealed by HPLC analysis. The carotenoid contents of IbOr plants were positively correlated with IbOr transcript levels. The levels of zeaxanthin were ∼ 12 times elevated in IbOr plants, whereas β-carotene increased ∼ 1.75 times higher than those of WT. Quantitative RT-PCR analysis revealed that most carotenoid biosynthetic pathway genes were up-regulated in the IbOr plants, including PDS, ZDS, LCY-β, CHY-β, ZEP and Pftf, whereas LCY-ɛ was down-regulated. Interestingly, CCD1, CCD4 and NCED, which are related to the degradation of carotenoids, were also up-regulated in the IbOr plants. Anthocyanin contents and transcription levels of associated biosynthetic genes seemed to be altered in the IbOr plants. The yields of storage roots and aerial parts of IbOr plants and WT plants were not significantly different under field cultivation. Taken together, these results indicate that overexpression of IbOr-Ins can increase the carotenoid contents of sweetpotato storage roots.

  20. El contenido de los mensajes icónicos: El discurso icónico como totalidad (2

    Directory of Open Access Journals (Sweden)

    Dr. Raymond Colle

    1999-01-01

    Full Text Available En el capítulo anterior, hemos hablado de los códigos icónicos de modo general, por cuanto tienen algunas características comunes, en particular el uso de figuras como factores de los significantes. Sin embargo, como lo hemos señalado al final, no todos se construyen ni articulan de la misma manera. Tal como las lenguas son muchas y los códigos lingüísticos se rigen por diferentes reglas -aunque sobre la base de fonemas unidos secuencialmente-, los códigos icónicos son también variados y regidos por reglas que complementan las ya señaladas. Para poder iniciar el análisis de un mensaje icónico, se debe por lo tanto identificar primero el tipo particular de código utilizado, del mismo modo que se ha de identificar un idioma antes de poder reconocer el sentido de las palabras en un mensaje verbal. Pero si es poco común pasar de un idioma a otro en el uso diario, es mucho más común pasar de un código icónico a otro. Por ello, es importante definir aquí primero los diversos códigos, para luego pasar a considerar los factores generales que juegan un papel en la interpretación.

  1. LOSS Revisited. II. The Relative Rates of Different Types of Supernovae Vary between Low- and High-mass Galaxies

    Science.gov (United States)

    Graur, Or; Bianco, Federica B.; Modjaz, Maryam; Shivvers, Isaac; Filippenko, Alexei V.; Li, Weidong; Smith, Nathan

    2017-03-01

    In Paper I of this series, we showed that the ratio between stripped-envelope (SE) supernova (SN) and Type II SN rates reveals a significant SE SN deficiency in galaxies with stellar masses ≲ {10}10 {M}ȯ . Here, we test this result by splitting the volume-limited subsample of the Lick Observatory Supernova Search (LOSS) SN sample into low- and high-mass galaxies and comparing the relative rates of various SN types found in them. The LOSS volume-limited sample contains 180 SNe and SN impostors and is complete for SNe Ia out to 80 Mpc and core-collapse SNe out to 60 Mpc. All of these transients were recently reclassified by us in Shivvers et al. We find that the relative rates of some types of SNe differ between low- and high-mass galaxies: SNe Ib and Ic are underrepresented by a factor of ∼3 in low-mass galaxies. These galaxies also contain the only examples of SN 1987A-like SNe in the sample and host about nine times as many SN impostors. Normal SNe Ia seem to be ∼30% more common in low-mass galaxies, making these galaxies better sources for homogeneous SN Ia cosmology samples. The relative rates of SNe IIb are consistent in both low- and high-mass galaxies. The same is true for broad-line SNe Ic, although our sample includes only two such objects. The results presented here are in tension with a similar analysis from the Palomar Transient Factory, especially as regards SNe IIb.

  2. Dicty_cDB: FC-IC1404 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1404 (Link to dictyBase) - - - Contig-U08328-1 FC-IC14... (Link to library) Clone ID FC-IC1404 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link t...o Contig Contig-U08328-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...in*h*hqll Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC1453 (FC-IC1453Q) /CSM/FC-IC... 32.0 %: nuclear 8.0 %: mitochondrial 4.0 %: cytoskeletal 4.0 %: Golgi >> prediction for FC-IC140

  3. Dicty_cDB: FC-IC0538 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC0538 (Link to dictyBase) - - - Contig-U16271-1 - (Link to Original site) FC-IC...(Link to library) Clone ID FC-IC0538 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig ...Contig-U16271-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...itfggcnrttcewfctfcewgatsfs*tt*f Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC....0 %: mitochondrial 4.0 %: peroxisomal >> prediction for FC-IC0538 is cyt 5' end seq. ID FC-IC0538F 5' end seq. >FC-IC

  4. Dicty_cDB: FC-IC1348 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1348 (Link to dictyBase) - - - Contig-U13052-1 FC-IC13... (Link to library) Clone ID FC-IC1348 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link t...o Contig Contig-U13052-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...qvivhyqriihnqd Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC1348 (FC-IC...les of secretory system >> prediction for FC-IC1348 is cyt 5' end seq. ID FC-IC

  5. Dicty_cDB: FC-IC1091 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1091 (Link to dictyBase) - - - Contig-U16382-1 - (Link to Original site) FC-IC...1091F 428 - - - - - - Show FC-IC1091 Library FC-IC (Link to library) Clone ID FC-IC1091 (Link to dic...skeletal 8.0 %: mitochondrial 4.0 %: vacuolar 4.0 %: endoplasmic reticulum >> prediction for FC-IC1091 is cyt 5' end seq. ID FC-IC...tyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Contig-U16382-1 Original site URL http://dic...tycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC1091Q.Seq.d/ Representative se

  6. Dicty_cDB: FC-IC0129 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC0129 (Link to dictyBase) - - - Contig-U07963-1 FC-IC01...29F (Link to Original site) FC-IC0129F 160 - - - - - - Show FC-IC0129 Library FC-IC (Link to library) Clone ID FC-IC.../FC-IC0401Q.Seq.d/ 281 2e-75 own update 2004.12.25 Homology vs DNA Score E Sequences producing signific... 4.0 %: peroxisomal >> prediction for FC-IC0129 is nuc 5' end seq. ID FC-IC...0129 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Contig-U07963-1 Original site URL http://dic

  7. Dicty_cDB: FC-IC0911 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC0911 (Link to dictyBase) - - - Contig-U15103-1 FC-IC09... (Link to library) Clone ID FC-IC0911 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link ...to Contig Contig-U15103-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...rwwifv**snfdciw*s*ksipk**n yntliw Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC... of secretory system >> prediction for FC-IC0911 is nuc 5' end seq. ID FC-IC0911F 5' end seq. >FC-IC0911F.Se

  8. Dicty_cDB: FC-IC0102 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC0102 (Link to dictyBase) - - - Contig-U16527-1 FC-IC01...02F (Link to Original site) FC-IC0102F 434 - - - - - - Show FC-IC0102 Library FC-IC (Link to library) Clone ID FC-IC...dtxisxpllnm--- Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC0102 (FC-IC...: cytoskeletal 4.0 %: vacuolar 4.0 %: vesicles of secretory system >> prediction for FC-IC...0102 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Contig-U16527-1 Original site URL http://dic

  9. Dicty_cDB: FC-IC0854 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC0854 (Link to dictyBase) - - - Contig-U16142-1 FC-IC08...ink to library) Clone ID FC-IC0854 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Co...ntig-U16142-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...nllkkkkkksvkyvfck**n Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC0854 (FC-IC... 36.0 %: nuclear 16.0 %: mitochondrial 4.0 %: cytoskeletal >> prediction for FC-IC0854 is cyt 5' end seq. ID FC-IC

  10. Dicty_cDB: FC-IC1202 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1202 (Link to dictyBase) - - - Contig-U16527-1 FC-IC12... (Link to library) Clone ID FC-IC1202 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link t...o Contig Contig-U16527-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...**cst*islpy*iw Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC1760 (FC-IC...20.0 %: mitochondrial 4.0 %: cytoskeletal 4.0 %: peroxisomal >> prediction for FC-IC1202 is cyt 5' end seq. ID FC-IC

  11. Dicty_cDB: FC-IC1239 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1239 (Link to dictyBase) - - - Contig-U16527-1 FC-IC12... (Link to library) Clone ID FC-IC1239 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link t...o Contig Contig-U16527-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...qiyldilslrnhmk Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC1760 (FC-IC...0 %: Golgi 4.0 %: cytoplasmic >> prediction for FC-IC1239 is end 5' end seq. ID FC-IC

  12. Dicty_cDB: FC-IC1688 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1688 (Link to dictyBase) - - - Contig-U16382-1 - (Link... to Original site) - - FC-IC1688Z 288 - - - - Show FC-IC1688 Library FC-IC (Link to library) Clone ID FC-IC1688 (Link to dic...IV Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC1688 (FC-IC...:FC-AG0... 414 e-112 1 ( AU275195 ) Dictyostelium discoideum gamete cDNA clone:FC-IC1... 414 e-112 1 ( AU272515 ) Dic...tyostelium discoideum gamete cDNA clone:FC-IC1... 414 e-112 1 ( AU272386 ) Dic

  13. Dicty_cDB: FC-IC1122 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1122 (Link to dictyBase) - - - Contig-U16527-1 FC-IC11... (Link to library) Clone ID FC-IC1122 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link t...o Contig Contig-U16527-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...**cst*islpy*iw Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC1760 (FC-IC...20.0 %: mitochondrial 4.0 %: cytoskeletal 4.0 %: peroxisomal >> prediction for FC-IC1122 is cyt 5' end seq. ID FC-IC

  14. Dicty_cDB: FC-IC1127 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1127 (Link to dictyBase) - - - Contig-U16527-1 FC-IC11... (Link to library) Clone ID FC-IC1127 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link t...o Contig Contig-U16527-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...**cst*islpy*iw Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC1760 (FC-IC...20.0 %: mitochondrial 4.0 %: cytoskeletal 4.0 %: peroxisomal >> prediction for FC-IC1127 is cyt 5' end seq. ID FC-IC

  15. Dicty_cDB: FC-IC1173 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1173 (Link to dictyBase) - - - Contig-U16527-1 FC-IC11... (Link to library) Clone ID FC-IC1173 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link t...o Contig Contig-U16527-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...qiyldilslrnhmk Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC1760 (FC-IC...0 %: Golgi 4.0 %: cytoplasmic >> prediction for FC-IC1173 is end 5' end seq. ID FC-IC

  16. Dicty_cDB: FC-IC0826 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC0826 (Link to dictyBase) - - - Contig-U08366-1 FC-IC08... (Link to library) Clone ID FC-IC0826 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link t...o Contig Contig-U08366-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...CFALIDLHLISGYWWWFDGAYFTVLEI Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC0826 (FC-IC...ne 12.0 %: mitochondrial 4.0 %: cytoskeletal 4.0 %: Golgi 4.0 %: cytoplasmic >> prediction for FC-IC0826 is end 5' end seq. ID FC-IC

  17. Dicty_cDB: FC-IC1048 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1048 (Link to dictyBase) - - - Contig-U07467-1 - (Link to Original site) FC-IC...1048F 172 - - - - - - Show FC-IC1048 Library FC-IC (Link to library) Clone ID FC-IC1048 (Link to dic...: cytoskeletal 4.0 %: plasma membrane 4.0 %: peroxisomal >> prediction for FC-IC1048 is mit 5' end seq. ID FC-IC...tyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Contig-U07467-1 Original site URL http://dic...tycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC1048Q.Seq.d/ Representative se

  18. Dicty_cDB: FC-IC1462 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1462 (Link to dictyBase) - G24314 DDB0202795 Contig-U08394-1 FC-IC... (Link to library) Clone ID FC-IC1462 (Link to dictyBase) Atlas ID - NBRP ID G24314 dic...fhiflvygkeilqq Homology vs CSM-cDNA Score E Sequences producing significant align...1462E (Link to Original site) FC-IC1462F 268 FC-IC1462Z 268 FC-IC1462P 516 FC-IC1462E 258 Show FC-IC1462 Library FC-IC...tyBase ID DDB0202795 Link to Contig Contig-U08394-1 Original site URL http://dic

  19. Dicty_cDB: FC-IC1198 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1198 (Link to dictyBase) - - - Contig-U16527-1 FC-IC11... (Link to library) Clone ID FC-IC1198 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link t...o Contig Contig-U16527-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...qiyldilslrnhmk Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC1760 (FC-IC...0 %: Golgi 4.0 %: cytoplasmic >> prediction for FC-IC1198 is end 5' end seq. ID FC-IC

  20. Dicty_cDB: FC-IC1539 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1539 (Link to dictyBase) - - - Contig-U16278-1 - (Link to Original site) FC-IC...1539F 679 - - - - - - Show FC-IC1539 Library FC-IC (Link to library) Clone ID FC-IC1539 (Link to dic...skkk*nkknxxxf*stxkkkkkkvcplgxnxpkpnf--- Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC... >> prediction for FC-IC1539 is mit 5' end seq. ID FC-IC1539F 5' end seq. >FC-IC1539F.S...tyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Contig-U16278-1 Original site URL http://dic

  1. Dicty_cDB: FC-IC0874 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC0874 (Link to dictyBase) - - - Contig-U16382-1 FC-IC08... (Link to library) Clone ID FC-IC0874 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link t...o Contig Contig-U16382-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...kpstpqpc Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC...cytoskeletal 4.0 %: peroxisomal >> prediction for FC-IC0874 is nuc 5' end seq. ID FC-IC0874F 5' end seq. >FC-IC

  2. Dicty_cDB: FC-IC0897 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC0897 (Link to dictyBase) - - - Contig-U10119-1 FC-IC08... (Link to library) Clone ID FC-IC0897 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link t...o Contig Contig-U10119-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/FC-IC/FC-IC...dklelkrtyiqd*irlpqypglrnyklskhfsw Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC...0 %: vacuolar 4.0 %: vesicles of secretory system >> prediction for FC-IC0897 is nuc 5' end seq. ID FC-IC0897F 5' end seq. >FC-IC

  3. Adoptive immunotherapy with Cl-IB-MECA-treated CD8+ T cells reduces melanoma growth in mice.

    Directory of Open Access Journals (Sweden)

    Antonella Montinaro

    Full Text Available Cl-IB-MECA is a selective A3 adenosine receptor agonist, which plays a crucial role in limiting tumor progression. In mice, Cl-IB-MECA administration enhances the anti-tumor T cell-mediated response. However, little is known about the activity of Cl-IB-MECA on CD8+ T cells. The aim of this study was to investigate the effect of ex vivo Cl-IB-MECA treatment of CD8+ T cells, adoptively transferred in melanoma-bearing mice. Adoptive transfer of Cl-IB-MECA-treated CD8+ T cells or a single administration of Cl-IB-MECA (20 ng/mouse inhibited tumor growth compared with the control group and significantly improved mouse survival. This was associated with the release of Th1-type cytokines and a greater influx of mature Langerin+ dendritic cells (LCs into the tumor microenvironment. CD8+ T cells treated with Cl-IB-MECA released TNF-α which plays a critical role in the therapeutic efficacy of these cells when injected to mice. Indeed, neutralization of TNF-α by a specific monoclonal Ab significantly blocked the anti-tumor activity of Cl-IB-MECA-treated T cells. This was due to the reduction in levels of cytotoxic cytokines and the presence of fewer LCs. In conclusion, these studies reveal that ex vivo treatment with Cl-IB-MECA improves CD8+ T cell adoptive immunotherapy for melanoma in a TNF-α-dependent manner.

  4. The first evidence of subgroup IB isolates of Cucumber mosaic virus in Ukraine

    Directory of Open Access Journals (Sweden)

    Shevchenko T. P.

    2015-02-01

    Full Text Available Aim. In current work, we proceeded with the strain attribution of Ukrainian isolates CMV based on the phylogenetic analysis of the partial sequences of the coat protein gene. Methods. ELISA, RT-PCR, DNA sequencing and phylogenetic analysis. Results. Cucumber mosaic virus (CMV is widespread among the variety of crops from the Cucurbitaceae and Solanaceae families in Ukraine. The symptomatic samples from different regions of Ukraine were collected and tested for the presence of CMV. The coat protein (CP gene of two isolates was amplified and sequenced. The partial nucleotide sequences of CP gene were determined and compared to those of other CMV strains belonging to the IA, IB and II subgroups. Comparison of the nucleotide sequences of Ukrainian isolates showed their similar identity percentages and close relationships with the subgroup IB strains from other countries. The highest nucleotide homology was shared with the strains ABI (Korea and SD (China. Conclusions. Based on the highest identities of the coat protein gene sequences and close phylogenetic relationships with the subgroup IB members of CMV, the Ukrainian isolates under study were identified as belonging to the subgroup IB. Our findings show for the first time an occurrence of the IB subgroup isolates of CMV in Ukraine.

  5. BUSINESS STRATEGY OF LARGE CONTRACTORS IN ADOPTING INDUSTRIALISED BUILDING SYSTEM (IBS: THE MALAYSIAN CASE

    Directory of Open Access Journals (Sweden)

    FRANKY AMBON

    2012-12-01

    Full Text Available Industrialised Building System (IBS is the term coined by the government and industry in Malaysia to represent the construction industry and the application of prefabrication method in building construction. The purpose of this exploratory research paper is to highlight business strategy being pursued by large Malaysian contractors in adopting IBS. The paper uses case study as research method. The analysis is based primarily on cross-case analysis and pattern matching technique. The paper observes contractors which involved in IBS are part of larger holding companies in a corporate set-up include design and manufacturing subsidiaries. The companies positioned themselves as one-stop total solution provider for IBS and offer a wider range of services from design, production, and installation to clients. To become competitive and able to create total solution, contractors need to establish cluster and consortium of integrated project team by creating a partnership when and where it is needed. A vendor development programme modelled along the lines of the development of automotive industry should also be established. Future empirical studies should extensively examine these areas, especially the development of business model for contractors. The availability of this model could help to accelerate the uptake of IBS among contractors.

  6. The Turkish version of the Rome III criteria for IBS is valid and reliable.

    Science.gov (United States)

    Ozgürsoy Uran, Berna Nilgun; Vardar, Rukiye; Karadakovan, Ayfer; Bor, Serhat

    2014-08-01

    In this study, we aimed to provide the usage of the Rome III criteria for irritable bowel syndrome (IBS) in the healthcare field by conducting validity and reliability studies in Turkey and to facilitate diagnosis of these patients. Item analysis of the Rome III criteria was performed, and the test was applied to 79 patients after their consistency had been validated with expert opinion. After the first application, the retest was applied to 77 cases, and the consistency between the two applications was examined by kappa analysis. IBS was diagnosed by expert opinion, which was accepted as 'the gold standard'. Cronbach's alpha of the Rome III criteria was calculated as 0.90. When the compliance between expert assessment and IBS Rome III diagnostic criteria was compared, the diagnostic criteria's sensitivity was determined as 78.6%, and their specificity was 82.9%. When the Rome III criteria test-retest agreement was analysed, the sensitivity, specificity and negative and positive predictive values of the Rome III diagnostic criteria were determined as 97.4%. In this study, the internal consistency of the Rome III criteria for diagnosis of patients with IBS in our country was found to be an important criterion because of the fact that the Rome III criteria have high internal consistency and validation, they are a reliable measurement tool, they are able to distinguish IBS-positive and -negative cases with the same rate as a specialist and their application is very easy.

  7. The Significance of Coordination for Industrialised Building System (IBS Precast Concrete in Construction Industry

    Directory of Open Access Journals (Sweden)

    Fitri Othman Mohd Khairul

    2017-01-01

    Full Text Available IBS precast concrete is construction system which is meant to improve the conventional construction process. However IBS precast concrete projects are suffering from serious problems such as cost overrun, delays and less quality of the end product. The absence of coordination is perceived as the reason for this issue. The purpose of this paper is to review the significance of coordination for IBS precast concrete in the construction industry. It if found that the fragmentation which occurs in the construction industry requires continuity of coordination due to the construction activities are intertwined in nature. Coordination is designated to assist stakeholders in completing and complementing each other with the paramount focus of achieving the objective. Proper coordination is required in delivering the desired construction product at the ideal time, cost and quality. As for the findings, the significance of coordination for IBS precast concrete can be seen through the precast concrete construction phases which consist of planning; design; manufacturing; transportation and installation/construction. These phases are meant to complement construction process with the purpose to reduce issues of fragmentation and enhance IBS precast concrete project delivery.

  8. TESTING THE ROLE OF SNe Ia FOR GALACTIC CHEMICAL EVOLUTION OF p-NUCLEI WITH TWO-DIMENSIONAL MODELS AND WITH s-PROCESS SEEDS AT DIFFERENT METALLICITIES

    Energy Technology Data Exchange (ETDEWEB)

    Travaglio, C. [INAF, Astrophysical Observatory Turin, Strada Osservatorio 20, I-10025 Pino Torinese (Turin), Italy B2FH Association, Turin (Italy); Gallino, R. [Dipartimento di Fisica, Università di Torino, Via P. Giuria 1, I-10125 Turin (Italy); Rauscher, T. [Centre for Astrophysics Research, School of Physics, Astronomy and Mathematics, University of Hertfordshire, Hatfield AL10 9AB (United Kingdom); Röpke, F. K. [Universität Würzburg, Am Hubland, D-97074 Würzburg (Germany); Hillebrandt, W., E-mail: travaglio@oato.inaf.it, E-mail: claudia.travaglio@b2fh.org [Max-Planck-Institut für Astrophysik, Karl-Schwarzschild-Str. 1, D-85748 Garching bei München (Germany)

    2015-01-20

    The bulk of p isotopes is created in the ''gamma processes'' mainly by sequences of photodisintegrations and beta decays in explosive conditions in Type Ia supernovae (SNIa) or in core collapse supernovae (ccSN). The contribution of different stellar sources to the observed distribution of p-nuclei in the solar system is still under debate. We explore single degenerate Type Ia supernovae in the framework of two-dimensional SNIa delayed-detonation explosion models. Travaglio et al. discussed the sensitivity of p-nuclei production to different SNIa models, i.e., delayed detonations of different strength, deflagrations, and the dependence on selected s-process seed distributions. Here we present a detailed study of p-process nucleosynthesis occurring in SNIa with s-process seeds at different metallicities. Based on the delayed-detonation model DDT-a of TRV11, we analyze the dependence of p-nucleosynthesis on the s-seed distribution obtained from different strengths of the {sup 13}C pocket. We also demonstrate that {sup 208}Pb seed alone changes the p-nuclei production considerably. The heavy-s seeds (140 ≤A < 208) contribute with about 30%-40% to the total light-p nuclei production up to {sup 132}Ba (with the exception of {sup 94}Mo and {sup 130}Ba, to which the heavy-s seeds contribute with about 15% only). Using a Galactic chemical evolution code from Travaglio et al., we study the contribution of SNIa to the solar stable p-nuclei. We find that explosions of Chandrasekhar-mass single degenerate systems produce a large amount of p-nuclei in our Galaxy, both in the range of light (A ≤ 120) and heavy p-nuclei, at almost flat average production factors (within a factor of about three). We discussed in details p-isotopes such as {sup 94}Mo with a behavior diverging from the average, which we attribute to uncertainties in the nuclear data or in SNIa modeling. Li et al. find that about 70% of all SNeIa are normal events. If these are explained in

  9. Animal experiments with the microelectronics neural bridge IC.

    Science.gov (United States)

    Li, Wenyuan; Pei, Fei; Wang, Zhigong; Lü, Xiaoying

    2012-01-01

    The combination of the neural science and the microelectronics science offers a new way to restore the function of central nervous system. A neural regeneration module is used to be implanted into body to bridge the damaged nerve. A microelectronics neural bridge IC designed in CSMC 0.5□m CMOS process which can detect the neural signal and stimulate the nerve is presented. The neural regeneration module is composed of the microelectronics neural bridge IC and some discrete devices. An animal experiment has been done to check whether the neural signal can be transmitted with the chip normally or not. The animal experiment results suggest that the neural regeneration module can make the neural signal transmit normally.

  10. THE LATEST ERUPTION OF PLANETARY NEBULA IC 2165

    Directory of Open Access Journals (Sweden)

    J. Bohigas

    2013-01-01

    Full Text Available Open slit high dispersion spectroscopic observations of the inner region of planetary nebula (PN IC 2165 indicate that the object has a relatively uniform and high electron temperature, with its density being much larger close to the PN nucleus. Abundances imply that it is a non-type I PN. Calcium and iron have been heavily depleted into grains. The ionized mass is at least ∼0.05 M⊙ . A photoionization model (Cloudy, version 10.00 assuming an inverse square law for the density and abundances typical of a non-type I PN, produced a fair replica of the spectrum and of all electron density and temperature sensitive line ratios, but not of the global properties of this object. All evidence indicates that IC 2165 was produced by a metal poor 2 M⊙ A5 V star that took off some 2 × 109 yr ago.

  11. Physical IC debug ─ backside approach and nanoscale challenge

    Directory of Open Access Journals (Sweden)

    U. Kerst

    2008-05-01

    Full Text Available Physical analysis for IC functionality in submicron technologies requires access through chip backside. Based upon typical global backside preparation with 50–100 µm moderate silicon thickness remaining, a state of the art of the analysis techniques available for this purpose is presented and evaluated for functional analysis and layout pattern resolution potential. A circuit edit technique valid for nano technology ICs, is also presented that is based upon the formation of local trenches using the bottom of Shallow Trench Isolation (STI as endpoint for Focused Ion Beam (FIB milling. As a derivative from this process, a locally ultra thin silicon device can be processed, creating a back surface as work bench for breakthrough applications of nanoscale analysis techniques to a fully functional circuit through chip backside. Several applications demonstrate the power and potential of this new approach.

  12. MagIC: Fluid dynamics in a spherical shell simulator

    Science.gov (United States)

    Wicht, J.; Gastine, T.; Barik, A.; Putigny, B.; Yadav, R.; Duarte, L.; Dintrans, B.

    2017-09-01

    MagIC simulates fluid dynamics in a spherical shell. It solves for the Navier-Stokes equation including Coriolis force, optionally coupled with an induction equation for Magneto-Hydro Dynamics (MHD), a temperature (or entropy) equation and an equation for chemical composition under both the anelastic and the Boussinesq approximations. MagIC uses either Chebyshev polynomials or finite differences in the radial direction and spherical harmonic decomposition in the azimuthal and latitudinal directions. The time-stepping scheme relies on a semi-implicit Crank-Nicolson for the linear terms of the MHD equations and a Adams-Bashforth scheme for the non-linear terms and the Coriolis force.

  13. Model Checking with Multi-Threaded IC3 Portfolios

    Science.gov (United States)

    2015-01-15

    Model Checking with Multi-Threaded IC3 Portfolios Sagar Chaki and Derrick Karimi Software Engineering Institute, Carnegie Mellon University {chaki...different runs varies randomly depending on the thread interleaving. The use of a portfolio of solvers to maximize the likelihood of a quick solution is...investigated. Using the Extreme Value theorem, the runtime of each variant, as well as their portfolios is analysed statistically. A formula for the

  14. Predicting levator avulsion from ICS POP-Q findings.

    Science.gov (United States)

    Pattillo Garnham, Alejandro; Guzmán Rojas, Rodrigo; Shek, Ka Lai; Dietz, Hans Peter

    2017-06-01

    Levator avulsion is a common consequence of vaginal childbirth. It is associated with symptomatic female pelvic organ prolapse and is also a predictor of recurrence after surgical correction. Skills and hardware necessary for diagnosis by imaging are, however, not universally available. Diagnosis of avulsion may benefit from an elevated index of suspicion. The aim of this study was to examine the predictive value of the International Continence Society Pelvic Organ Prolapse Quantification (ICS POP-Q) for the diagnosis of levator avulsion by tomographic 4D translabial ultrasound. This is a retrospective analysis of data obtained in a tertiary urogynaecological unit. Subjects underwent a standardised interview, POP-Q examination and 4D translabial pelvic floor ultrasound. Avulsion of the puborectalis muscle was diagnosed by tomographic ultrasound imaging. We tested components of the ICS POP-Q associated with symptomatic prolapse and other known predictors of avulsion, including previous prolapse repair and forceps delivery with uni- and multivariate logistic regression. A risk score was constructed for clinical use. The ICS POP-Q components Ba, C, gh and pb were all significantly associated with avulsion on multivariate analysis, along with previous prolapse repair and forceps delivery. A score was assigned for each of these variables and patients were classified as low, moderate or high risk according to total score. The odds of finding an avulsion on ultrasound in patients in the "high risk" group were 12.8 times higher than in the "low risk" group. Levator avulsion is associated with ICS POP-Q measures. Together with simple clinical data, it is possible to predict the risk of avulsion using a scoring system. This may be useful in clinical practice by modifying the index of suspicion for the condition.

  15. Round Robin analysis of G Ic interlaminar fracture test

    Science.gov (United States)

    Davies, P.

    1996-05-01

    This note presents the results of an exercise to evaluate the variation in values of G Ic at initiation, determined independently by 36 researchers interpreting the same load-displacement curve from a mode I double cantilever beam (DCB) test on unidirectional carbon fibre reinforced polymer composite. The results indicate a significantly larger coefficient of variation for values corresponding to a definition of initiation at non-linearity on the load-displacement curve than for a 5% compliance offset criterion.

  16. Sequential clustering of star formations in IC 1396

    Institute of Scientific and Technical Information of China (English)

    Ya-Fang Huang; Jin-Zeng Li

    2013-01-01

    We present a comprehensive study of the H Ⅱ region IC 1396 and its star forming activity,in which multi-wavelength data ranging from the optical to the nearand far-infrared were employed.The surface density distribution of all the 2MASS sources with a certain detection toward IC 1396 indicates the existence of a compact cluster spatially consistent with the position of the exciting source of the H Ⅱ region,HD 206267.The spatial distribution of the sources with excessive infrared emission,selected based on archived 2MASS data,reveals the existence of four sub-clusters in this region.One is associated with the open cluster Trumpler 37.The other three are found to be spatially coincident with the bright rims of the H Ⅱ region.All the sources with excessive emission in the near infrared are cross-identified with AKARI IRC data.An analysis of the spectral energy distributions (SEDs) of the resultant sample leads to the identification of eight CLASS I,15 CLASS Ⅱ and 15 CLASS Ⅲ sources in IC 1396.Optical identification of the sample sources with R magnitudes brighter than 17 mag corroborates the results from the SED analysis.Based on the spatial distribution of the infrared young stellar objects at different evolutionary stages,the surrounding sub-clusters located in the bright rims are believed to be younger than the central one.This is consistent with a scenario of sequential star formation in this region.Imaging data of a dark patch in IC 1396 by Herschel SPIRE,on the other hand,indicate the presence of two far-infrared cores in LDN 1111,which are likely to be a new generation of protostellar objects in formation.So we infer that the star formation process in this H Ⅱ region was not continuous but rather episodic.

  17. On the progenitor of the Type Ic supernova 2002ap

    NARCIS (Netherlands)

    Smartt, SJ; Ramirez-Ruiz, E; Gilmore, GF; Meikle, WPS; Ferguson, AMN; Knapen, JH

    2002-01-01

    This Letter presents wide-field optical and near-IR (UBVRIHalphaK') images of the galaxy M74 that were taken between 0.6 and 8.3 yr before the discovery of the Type Ic supernova 2002ap. We have located the position of the supernova on these images with an accuracy of 0."3. We find no sign of a proge

  18. Analog IC Design at the University of Twente

    OpenAIRE

    2007-01-01

    This article describes some recent research results from the IC Design group of the University of Twente, located in Enschede, The Netherlands. Our research focuses on analog CMOS circuit design with emphasis on high frequency and broadband circuits. With the trend of system integration in mind, we try to develop new circuit techniques that enable the next steps in system integration in nanometer CMOS technology. Our research funding comes from industry, as well as from governmental organizat...

  19. ICS and COPD: Time to clear the air

    OpenAIRE

    Russell, Richard

    2009-01-01

    Paul A Ford, Richard EK Russell, Peter J BarnesAirway Disease Section, National Heart and Lung Institute, Imperial College, London, UKThe debate about what constitutes the correct treatment for COPD has recently intensified. This discussion has grumbled on ever since the first multicenter trials using inhaled corticosteroids (ICS) in chronic obstructive pulmonary disease (COPD) such as the European Respiratory Society study on chronic obstructive pulmonary disease (EUROSCOP) and Inhaled Stero...

  20. Klinefelter's Syndrome with Seizure, Pseudohypoparathyroidism Type Ib and Multiple Endocrine Dysfunctions

    Directory of Open Access Journals (Sweden)

    Chwen-Yi Yang

    2005-12-01

    Full Text Available Klinefelter's syndrome is rarely associated with hypocalcemia, especially pseudohypoparathyroidism (PHP type Ib. We describe a case of Klinefelter's syndrome associated with seizure, PHP type Ib and multiple endocrine dysfunctions. A 19-year-old Taiwanese male was admitted due to seizures with loss of consciousness. He had been diagnosed with Klinefelter's syndrome with seizure disorder and hypocalcemia 3 months previously. Physical examination revealed eunuchoidism but no osteodystrophy, while laboratory data revealed severe hypocalcemia, hyperphosphatemia, and elevated parathyroid hormone. Chromosomal study showed 47, XXY. Osteoporosis was found on chest and abdominal radiography. Dense calcification in the cerebrum and cerebellum was shown on brain computed tomography and magnetic resonance imaging. Elevation of the patient's serum calcium level was noted after vitamin D and calcium carbonate supplements were given. Klinefelter's syndrome is rarely associated with PHP type Ib; our patient's hypocalcemia improved after long-term aggressive treatment.