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Sample records for hyperpolarized xenon nuclear

  1. Hyperpolarized Xenon Nuclear Magnetic Resonance (NMR of Building Stone Materials

    Directory of Open Access Journals (Sweden)

    Michele Mauri

    2012-09-01

    Full Text Available We have investigated several building stone materials, including minerals and rocks, using continuous flow hyperpolarized xenon (CF-HP NMR spectroscopy to probe the surface composition and porosity. Chemical shift and line width values are consistent with petrographic information. Rare upfield shifts were measured and attributed to the presence of transition metal cations on the surface. The evolution of freshly cleaved rocks exposed to the atmosphere was also characterized. The CF-HP 129Xe NMR technique is non-destructive and it could complement currently used techniques, like porosimetry and microscopy, providing additional information on the chemical nature of the rock surface and its evolution.

  2. Molecular MRI based on hyper-polarized xenon

    International Nuclear Information System (INIS)

    Tassali, Nawal

    2012-01-01

    Magnetic Resonance Imaging (MRI) has a high importance in medicine as it enables the observation of the organs inside the body without the use of radiative or invasive techniques. However it is known to suffer from poor sensitivity. To circumvent this limitation, a key solution resides in the use of hyper-polarized species. Among the entities with which we can drastically increase nuclear polarization, xenon has very specific properties through its interactions with its close environment that lead to a wide chemical shift bandwidth. The goal is thus to use it as a tracer. This PhD thesis focuses on the concept of 129 Xe MRI-based sensors for the detection of biological events. In this approach, hyper-polarized xenon is vectorized to biological targets via functionalized host systems, and then localized thanks to fast dedicated MRI sequences. The conception and set-up of a spin-exchange optical pumping device is first described. Then studies about the interaction of the hyper-polarized noble gas with new cryptophanes susceptible to constitute powerful host molecules are detailed. Also the implementation of recent MRI sequences optimized for the transient character of the hyper-polarization and taking profit of the xenon in-out exchange is described. Applications of this approach for the detection of metallic ions and cellular receptors are studied. Finally, our first in vivo results on a small animal model are presented. (author) [fr

  3. Validating excised rodent lungs for functional hyperpolarized xenon-129 MRI.

    Directory of Open Access Journals (Sweden)

    David M L Lilburn

    Full Text Available Ex vivo rodent lung models are explored for physiological measurements of respiratory function with hyperpolarized (hp (129Xe MRI. It is shown that excised lung models allow for simplification of the technical challenges involved and provide valuable physiological insights that are not feasible using in vivo MRI protocols. A custom designed breathing apparatus enables MR images of gas distribution on increasing ventilation volumes of actively inhaled hp (129Xe. Straightforward hp (129Xe MRI protocols provide residual lung volume (RV data and permit for spatially resolved tracking of small hp (129Xe probe volumes during the inhalation cycle. Hp (129Xe MRI of lung function in the excised organ demonstrates the persistence of post mortem airway responsiveness to intravenous methacholine challenges. The presented methodology enables physiology of lung function in health and disease without additional regulatory approval requirements and reduces the technical and logistical challenges with hp gas MRI experiments. The post mortem lung functional data can augment histological measurements and should be of interest for drug development studies.

  4. The role of hyperpolarized {sup 129}xenon in MR imaging of pulmonary function

    Energy Technology Data Exchange (ETDEWEB)

    Ebner, Lukas [Cardiothoracic Imaging, Duke University Medical Center, Department of Radiology, Duke University, Durham, NC (United States); Kammerman, Jeff [Department of Medical Physics, University of Wisconsin, Madison, WI (United States); Driehuys, Bastiaan [Center for In Vivo Microscopy, Duke University, Durham, NC (United States); Schiebler, Mark L. [Department of Radiology, University of Wisconsin, Madison, WI (United States); Cadman, Robert V. [Department of Medical Physics, University of Wisconsin, Madison, WI (United States); Fain, Sean B., E-mail: sfain@wisc.edu [Departments of Medical Physics, Radiology, and Biomedical Engineering, University of Wisconsin, Madison, WI (United States)

    2017-01-15

    Highlights: • Recent advances in hyperpolarized 129Xe MRI are reviewed. • Xenon MRI allows for functional imaging of ventilation, diffusion, and gas exchange. • Xenon’s unique gas exchange imaging capabilities are highlighted. • Applications to obstructive and restrictive lung diseases are presented. • These advances are ready for translation to clinical applications. - Abstract: In the last two decades, functional imaging of the lungs using hyperpolarized noble gases has entered the clinical stage. Both helium ({sup 3}He) and xenon ({sup 129}Xe) gas have been thoroughly investigated for their ability to assess both the global and regional patterns of lung ventilation. With advances in polarizer technology and the current transition towards the widely available {sup 129}Xe gas, this method is ready for translation to the clinic. Currently, hyperpolarized (HP) noble gas lung MRI is limited to selected academic institutions; yet, the promising results from initial clinical trials have drawn the attention of the pulmonary medicine community. HP {sup 129}Xe MRI provides not only 3-dimensional ventilation imaging, but also unique capabilities for probing regional lung physiology. In this review article, we aim to (1) provide a brief overview of current ventilation MR imaging techniques, (2) emphasize the role of HP {sup 129}Xe MRI within the array of different imaging strategies, (3) discuss the unique imaging possibilities with HP {sup 129}Xe MRI, and (4) propose clinical applications.

  5. The role of hyperpolarized 129xenon in MR imaging of pulmonary function

    International Nuclear Information System (INIS)

    Ebner, Lukas; Kammerman, Jeff; Driehuys, Bastiaan; Schiebler, Mark L.; Cadman, Robert V.; Fain, Sean B.

    2017-01-01

    Highlights: • Recent advances in hyperpolarized 129Xe MRI are reviewed. • Xenon MRI allows for functional imaging of ventilation, diffusion, and gas exchange. • Xenon’s unique gas exchange imaging capabilities are highlighted. • Applications to obstructive and restrictive lung diseases are presented. • These advances are ready for translation to clinical applications. - Abstract: In the last two decades, functional imaging of the lungs using hyperpolarized noble gases has entered the clinical stage. Both helium ( 3 He) and xenon ( 129 Xe) gas have been thoroughly investigated for their ability to assess both the global and regional patterns of lung ventilation. With advances in polarizer technology and the current transition towards the widely available 129 Xe gas, this method is ready for translation to the clinic. Currently, hyperpolarized (HP) noble gas lung MRI is limited to selected academic institutions; yet, the promising results from initial clinical trials have drawn the attention of the pulmonary medicine community. HP 129 Xe MRI provides not only 3-dimensional ventilation imaging, but also unique capabilities for probing regional lung physiology. In this review article, we aim to (1) provide a brief overview of current ventilation MR imaging techniques, (2) emphasize the role of HP 129 Xe MRI within the array of different imaging strategies, (3) discuss the unique imaging possibilities with HP 129 Xe MRI, and (4) propose clinical applications.

  6. MR imaging of the stomach and relaxation measurement with intraluminal hyperpolarized 129Xenon gas

    International Nuclear Information System (INIS)

    Yanagawa, Yasuhiro; Kimura, Atsuomi; Fujiwara, Hideaki; Kinoshita, Yoshimasa; Hattori, Mineyuki; Hiraga, Takashi; Iida, Hidehiro

    2001-01-01

    Using laser optical pumping, the nuclear spin polarization of noble gases can be strongly enhanced. The purpose of this study was to make a simple apparatus that can provide hyperpolarized 129 Xe gas, which can then be used in an attempt to obtain magnetic resonance imaging (MRI). We would also like to study the relaxation behavior of hyperpolarized 129 Xe gas through the measurement of the relaxation time. First, we demonstrated that hyperpolarized 129 Xe gas can be applied to magnetic resonance imaging of the stomach, by using a rat as a model. This was performed under a 4.7 T magnet field using the following imaging parameters for the hyperpolarized 129 Xe gas: TR=50 ms, TE=15 ms, FOV=10 x 10 cm 2 , matrix size 64 x 64, THK=2.54 cm. By using these parameters, we were able to obtain a hyperpolarized image of the stomach in rats for the first time. Next, we measured the relaxation times of the hyperpolarized 129 Xe gas enclosed in cavities such as the stomach of rats as well as in phantoms created by glass and gelatin bulbs. The cavity size dependency of the relaxation time was analyzed on the basis of the kinetic theory of gases. This analysis showed a linear relationship between the relaxation rate (1/T 1 ) and a square inverse of the cavity diameter (1/d 2 ). From this relationship, the wall effect on the 129 Xe relaxation can be estimated in the novel parameter t 1 , wall . This shows drastic dependency on the material of the wall, suggesting a potential use of the relaxation experiment as a diagnostic tool for organ surfaces in the future. (author)

  7. Effects of superparamagnetic iron oxide nanoparticles on the longitudinal and transverse relaxation of hyperpolarized xenon gas

    Science.gov (United States)

    Burant, Alex; Antonacci, Michael; McCallister, Drew; Zhang, Le; Branca, Rosa Tamara

    2018-06-01

    SuperParamagnetic Iron Oxide Nanoparticles (SPIONs) are often used in magnetic resonance imaging experiments to enhance Magnetic Resonance (MR) sensitivity and specificity. While the effect of SPIONs on the longitudinal and transverse relaxation time of 1H spins has been well characterized, their effect on highly diffusive spins, like those of hyperpolarized gases, has not. For spins diffusing in linear magnetic field gradients, the behavior of the magnetization is characterized by the relative size of three length scales: the diffusion length, the structural length, and the dephasing length. However, for spins diffusing in non-linear gradients, such as those generated by iron oxide nanoparticles, that is no longer the case, particularly if the diffusing spins experience the non-linearity of the gradient. To this end, 3D Monte Carlo simulations are used to simulate the signal decay and the resulting image contrast of hyperpolarized xenon gas near SPIONs. These simulations reveal that signal loss near SPIONs is dominated by transverse relaxation, with little contribution from T1 relaxation, while simulated image contrast and experiments show that diffusion provides no appreciable sensitivity enhancement to SPIONs.

  8. Pathway to cryogen free production of hyperpolarized Krypton-83 and Xenon-129.

    Directory of Open Access Journals (Sweden)

    Joseph S Six

    Full Text Available Hyperpolarized (hp (129Xe and hp (83Kr for magnetic resonance imaging (MRI are typically obtained through spin-exchange optical pumping (SEOP in gas mixtures with dilute concentrations of the respective noble gas. The usage of dilute noble gases mixtures requires cryogenic gas separation after SEOP, a step that makes clinical and preclinical applications of hp (129Xe MRI cumbersome. For hp (83Kr MRI, cryogenic concentration is not practical due to depolarization that is caused by quadrupolar relaxation in the condensed phase. In this work, the concept of stopped flow SEOP with concentrated noble gas mixtures at low pressures was explored using a laser with 23.3 W of output power and 0.25 nm linewidth. For (129Xe SEOP without cryogenic separation, the highest obtained MR signal intensity from the hp xenon-nitrogen gas mixture was equivalent to that arising from 15.5±1.9% spin polarized (129Xe in pure xenon gas. The production rate of the hp gas mixture, measured at 298 K, was 1.8 cm(3/min. For hp (83Kr, the equivalent of 4.4±0.5% spin polarization in pure krypton at a production rate of 2 cm(3/min was produced. The general dependency of spin polarization upon gas pressure obtained in stopped flow SEOP is reported for various noble gas concentrations. Aspects of SEOP specific to the two noble gas isotopes are discussed and compared with current theoretical opinions. A non-linear pressure broadening of the Rb D(1 transition was observed and taken into account for the qualitative description of the SEOP process.

  9. Pathway to cryogen free production of hyperpolarized Krypton-83 and Xenon-129.

    Science.gov (United States)

    Six, Joseph S; Hughes-Riley, Theodore; Stupic, Karl F; Pavlovskaya, Galina E; Meersmann, Thomas

    2012-01-01

    Hyperpolarized (hp) (129)Xe and hp (83)Kr for magnetic resonance imaging (MRI) are typically obtained through spin-exchange optical pumping (SEOP) in gas mixtures with dilute concentrations of the respective noble gas. The usage of dilute noble gases mixtures requires cryogenic gas separation after SEOP, a step that makes clinical and preclinical applications of hp (129)Xe MRI cumbersome. For hp (83)Kr MRI, cryogenic concentration is not practical due to depolarization that is caused by quadrupolar relaxation in the condensed phase. In this work, the concept of stopped flow SEOP with concentrated noble gas mixtures at low pressures was explored using a laser with 23.3 W of output power and 0.25 nm linewidth. For (129)Xe SEOP without cryogenic separation, the highest obtained MR signal intensity from the hp xenon-nitrogen gas mixture was equivalent to that arising from 15.5±1.9% spin polarized (129)Xe in pure xenon gas. The production rate of the hp gas mixture, measured at 298 K, was 1.8 cm(3)/min. For hp (83)Kr, the equivalent of 4.4±0.5% spin polarization in pure krypton at a production rate of 2 cm(3)/min was produced. The general dependency of spin polarization upon gas pressure obtained in stopped flow SEOP is reported for various noble gas concentrations. Aspects of SEOP specific to the two noble gas isotopes are discussed and compared with current theoretical opinions. A non-linear pressure broadening of the Rb D(1) transition was observed and taken into account for the qualitative description of the SEOP process.

  10. WE-AB-202-07: Ventilation CT: Voxel-Level Comparison with Hyperpolarized Helium-3 & Xenon-129 MRI

    Energy Technology Data Exchange (ETDEWEB)

    Tahir, B; Marshall, H; Hughes, P; Stewart, N; Horn, F; Collier, G; Norquay, G; Hart, K; Swinscoe, J; Hatton, M; Wild, J; Ireland, R [University of Sheffield, Sheffield (United Kingdom)

    2016-06-15

    Purpose: To compare the spatial correlation of ventilation surrogates computed from inspiratory and expiratory breath-hold CT with hyperpolarized Helium-3 & Xenon-129 MRI in a cohort of lung cancer patients. Methods: 5 patients underwent expiration & inspiration breath-hold CT. Xenon-129 & {sup 1}H MRI were also acquired at the same inflation state as inspiratory CT. This was followed immediately by acquisition of Helium-3 & {sup 1}H MRI in the same breath and at the same inflation state as inspiratory CT. Expiration CT was deformably registered to inspiration CT for calculation of ventilation CT from voxel-wise differences in Hounsfield units. Inspiration CT and the Xenon-129’s corresponding anatomical {sup 1}H MRI were registered to Helium-3 MRI via the same-breath anatomical {sup 1}H MRI. This enabled direct comparison of CT ventilation with Helium-3 MRI & Xenon-129 MRI for the median values in corresponding regions of interest, ranging from finer to coarser in-plane dimensions of 10 by 10, 20 by 20, 30 by 30 and 40 by 40, located within the lungs as defined by the same-breath {sup 1}H MRI lung mask. Spearman coefficients were used to assess voxel-level correlation. Results: The median Spearman’s coefficients of ventilation CT with Helium-3 & Xenon-129 MRI for ROIs of 10 by 10, 20 by 20, 30 by 30 and 40 by 40 were 0.52, 0.56, 0.60 and 0.68 and 0.40, 0.42, 0.52 and 0.70, respectively. Conclusion: This work demonstrates a method of acquiring CT & hyperpolarized gas MRI (Helium-3 & Xenon-129 MRI) in similar breath-holds to enable direct spatial comparison of ventilation maps. Initial results show moderate correlation between ventilation CT & hyperpolarized gas MRI, improving for coarser regions which could be attributable to the inherent noise in CT intensity, non-ventilatory effects and registration errors at the voxel-level. Thus, it may be more beneficial to quantify ventilation at a more regional level.

  11. Optical hyperpolarization of 13C nuclear spins in nanodiamond ensembles

    Science.gov (United States)

    Chen, Q.; Schwarz, I.; Jelezko, F.; Retzker, A.; Plenio, M. B.

    2015-11-01

    Dynamical nuclear polarization holds the key for orders of magnitude enhancements of nuclear magnetic resonance signals which, in turn, would enable a wide range of novel applications in biomedical sciences. However, current implementations of DNP require cryogenic temperatures and long times for achieving high polarization. Here we propose and analyze in detail protocols that can achieve rapid hyperpolarization of 13C nuclear spins in randomly oriented ensembles of nanodiamonds at room temperature. Our protocols exploit a combination of optical polarization of electron spins in nitrogen-vacancy centers and the transfer of this polarization to 13C nuclei by means of microwave control to overcome the severe challenges that are posed by the random orientation of the nanodiamonds and their nitrogen-vacancy centers. Specifically, these random orientations result in exceedingly large energy variations of the electron spin levels that render the polarization and coherent control of the nitrogen-vacancy center electron spins as well as the control of their coherent interaction with the surrounding 13C nuclear spins highly inefficient. We address these challenges by a combination of an off-resonant microwave double resonance scheme in conjunction with a realization of the integrated solid effect which, together with adiabatic rotations of external magnetic fields or rotations of nanodiamonds, leads to a protocol that achieves high levels of hyperpolarization of the entire nuclear-spin bath in a randomly oriented ensemble of nanodiamonds even at room temperature. This hyperpolarization together with the long nuclear-spin polarization lifetimes in nanodiamonds and the relatively high density of 13C nuclei has the potential to result in a major signal enhancement in 13C nuclear magnetic resonance imaging and suggests functionalized and hyperpolarized nanodiamonds as a unique probe for molecular imaging both in vitro and in vivo.

  12. NMR study of hyper-polarized {sup 129}Xe and applications to liquid-phase NMR experiments; Etude de la resonance magnetique nucleaire du Xenon{sup 129} hyperpolarise et applications en RMN des liquides

    Energy Technology Data Exchange (ETDEWEB)

    Marion, D

    2008-07-15

    In liquid samples where both nuclear polarization and spin density are strong, the magnetization dynamics, which can be analysed by NMR (nuclear magnetic resonance) methods, is deeply influenced by the internal couplings induced by local dipolar fields. The present thesis describes some of the many consequences associated to the presence in the sample of concentrated xenon hyper-polarized by an optical pumping process. First, we deal with the induced modifications in frequency and line width of the proton and xenon spectra, then we present the results of SPIDER, a coherent polarization transfer experiment designed to enhance the polarization of protons, in order to increase their NMR signal level. A third part is dedicated to the description of the apparition of repeated chaotic maser emissions by un unstable xenon magnetization coupled to the detection coil tuned at the xenon Larmor frequency (here 138 MHz). In the last part, we present a new method allowing a better tuning of any NMR detection probe and resulting in sensible gains in terms of sensitivity and signal shaping. Finally, we conclude with a partial questioning of the classical relaxation theory in the specific field of highly polarized and concentrated spin systems in a liquid phase. (author)

  13. Recycling and imaging of nuclear singlet hyperpolarization

    DEFF Research Database (Denmark)

    Pileio, Giuseppe; Bowen, Sean; Laustsen, Christoffer

    2013-01-01

    observation of the same batch of polarized nuclei over a period of 30 min and more. We report a recycling protocol in which the enhanced nuclear polarization achieved by dissolution-DNP is observed with full intensity and then returned to singlet order. MRI experiments may be run on a portion of the available...

  14. Quantitative chemical exchange saturation transfer with hyperpolarized nuclei (qHyper-CEST): sensing xenon-host exchange dynamics and binding affinities by NMR.

    Science.gov (United States)

    Kunth, M; Witte, C; Schröder, L

    2014-11-21

    The reversible binding of xenon to host molecules has found numerous applications in nuclear magnetic resonance studies. Quantitative characterization of the Xe exchange dynamics is important to understand and optimize the physico-chemical behavior of such Xe hosts, but is often challenging to achieve at low host concentrations. We have investigated a sensitive quantification technique based on chemical exchange saturation transfer with hyperpolarized nuclei, qHyper-CEST. Using simulated signals we demonstrated that qHyper-CEST yielded accurate and precise results and was robust in the presence of large amounts of noise (10%). This is of particular importance for samples with completely unknown exchange rates. Using these findings we experimentally determined the following exchange parameters for the Xe host cryptophane-A monoacid in dimethyl sulfoxide in one type of experiment: the ratio of bound and free Xe, the Xe exchange rate, the resonance frequencies of free and bound Xe, the Xe host occupancy, and the Xe binding constant. Taken together, qHyper-CEST facilitates sensitive quantification of the Xe exchange dynamics and binding to hydrophobic cavities and has the potential to analyze many different host systems or binding sites. This makes qHyper-CEST an indispensable tool for the efficient design of highly specific biosensors.

  15. Ionization and scintillation of nuclear recoils in gaseous xenon

    Energy Technology Data Exchange (ETDEWEB)

    Renner, J., E-mail: jrenner@lbl.gov [Lawrence Berkeley National Laboratory (LBNL), 1 Cyclotron Road, Berkeley, CA 94720 (United States); Department of Physics, University of California, Berkeley, CA 94720 (United States); Gehman, V.M.; Goldschmidt, A.; Matis, H.S.; Miller, T.; Nakajima, Y.; Nygren, D.; Oliveira, C.A.B.; Shuman, D. [Lawrence Berkeley National Laboratory (LBNL), 1 Cyclotron Road, Berkeley, CA 94720 (United States); Álvarez, V. [Instituto de Física Corpuscular (IFIC), CSIC & Universitat de València, Calle Catedrático José Beltrán, 2, 46980 Paterna, Valencia (Spain); Borges, F.I.G. [Departamento de Fisica, Universidade de Coimbra, Rua Larga, 3004-516 Coimbra (Portugal); Cárcel, S. [Instituto de Física Corpuscular (IFIC), CSIC & Universitat de València, Calle Catedrático José Beltrán, 2, 46980 Paterna, Valencia (Spain); Castel, J.; Cebrián, S. [Laboratorio de Física Nuclear y Astropartículas, Universidad de Zaragoza, Calle Pedro Cerbuna 12, 50009 Zaragoza (Spain); Cervera, A. [Instituto de Física Corpuscular (IFIC), CSIC & Universitat de València, Calle Catedrático José Beltrán, 2, 46980 Paterna, Valencia (Spain); Conde, C.A.N. [Departamento de Fisica, Universidade de Coimbra, Rua Larga, 3004-516 Coimbra (Portugal); and others

    2015-09-01

    Ionization and scintillation produced by nuclear recoils in gaseous xenon at approximately 14 bar have been simultaneously observed in an electroluminescent time projection chamber. Neutrons from radioisotope α-Be neutron sources were used to induce xenon nuclear recoils, and the observed recoil spectra were compared to a detailed Monte Carlo employing estimated ionization and scintillation yields for nuclear recoils. The ability to discriminate between electronic and nuclear recoils using the ratio of ionization to primary scintillation is demonstrated. These results encourage further investigation on the use of xenon in the gas phase as a detector medium in dark matter direct detection experiments.

  16. Nuclear spin-spin coupling in a van der Waals-bonded system: xenon dimer.

    Science.gov (United States)

    Vaara, Juha; Hanni, Matti; Jokisaari, Jukka

    2013-03-14

    Nuclear spin-spin coupling over van der Waals bond has recently been observed via the frequency shift of solute protons in a solution containing optically hyperpolarized (129)Xe nuclei. We carry out a first-principles computational study of the prototypic van der Waals-bonded xenon dimer, where the spin-spin coupling between two magnetically non-equivalent isotopes, J((129)Xe - (131)Xe), is observable. We use relativistic theory at the four-component Dirac-Hartree-Fock and Dirac-density-functional theory levels using novel completeness-optimized Gaussian basis sets and choosing the functional based on a comparison with correlated ab initio methods at the nonrelativistic level. J-coupling curves are provided at different levels of theory as functions of the internuclear distance in the xenon dimer, demonstrating cross-coupling effects between relativity and electron correlation for this property. Calculations on small Xe clusters are used to estimate the importance of many-atom effects on J((129)Xe - (131)Xe). Possibilities of observing J((129)Xe - (131)Xe) in liquid xenon are critically examined, based on molecular dynamics simulation. A simplistic spherical model is set up for the xenon dimer confined in a cavity, such as in microporous materials. It is shown that the on the average shorter internuclear distance enforced by the confinement increases the magnitude of the coupling as compared to the bulk liquid case, rendering J((129)Xe - (131)Xe) in a cavity a feasible target for experimental investigation.

  17. Pulmonary hyperpolarized (129) Xe morphometry for mapping xenon gas concentrations and alveolar oxygen partial pressure: Proof-of-concept demonstration in healthy and COPD subjects.

    Science.gov (United States)

    Ouriadov, A; Farag, A; Kirby, M; McCormack, D G; Parraga, G; Santyr, G E

    2015-12-01

    Diffusion-weighted (DW) hyperpolarized (129) Xe morphometry magnetic resonance imaging (MRI) can be used to map regional differences in lung tissue micro-structure. We aimed to generate absolute xenon concentration ([Xe]) and alveolar oxygen partial pressure (pA O2 ) maps by extracting the unrestricted diffusion coefficient (D0 ) of xenon as a morphometric parameter. In this proof-of-concept demonstration, morphometry was performed using multi b-value (0, 12, 20, 30 s/cm(2) ) DW hyperpolarized (129) Xe images obtained in four never-smokers and four COPD ex-smokers. Morphometric parameters and D0 maps were computed and the latter used to generate [Xe] and pA O2 maps. Xenon concentration phantoms estimating a range of values mimicking those observed in vivo were also investigated. Xenon D0 was significantly increased (P = 0.035) in COPD (0.14 ± 0.03 cm(2) /s) compared with never-smokers (0.12 ± 0.02 cm(2) /s). COPD ex-smokers also had significantly decreased [Xe] (COPD = 8 ± 7% versus never-smokers = 13 ± 8%, P = 0.012) and increased pA O2 (COPD = 18 ± 3% versus never-smokers = 15 ± 3%, P = 0.009) compared with never-smokers. Phantom measurements showed the expected dependence of D0 on [Xe] over the range of concentrations anticipated in vivo. DW hyperpolarized (129) Xe MRI morphometry can be used to simultaneously map [Xe] and pA O2 in addition to providing micro-structural biomarkers of emphysematous destruction in COPD. Phantom measurements of D0 ([Xe]) supported the hypotheses that differences in subjects may reflect differences in functional residual capacity. © 2014 Wiley Periodicals, Inc.

  18. The role of level anti-crossings in nuclear spin hyperpolarization

    NARCIS (Netherlands)

    Ivanov, Konstantin L.; Pravdivtsev, Andrey N.; Yurkovskaya, Alexandra V.; Vieth, Hans Martin; Kaptein, R

    2014-01-01

    Nuclear spin hyperpolarization is an important resource for increasing the sensitivity of NMR spectroscopy and MRI. Signal enhancements can be as large as 3-4 orders of magnitude. In hyperpolarization experiments, it is often desirable to transfer the initial polarization to other nuclei of choice,

  19. Novel methods and applications of NMR and MRI. Low-power RF excitation and hyperpolarized Xenon-129

    International Nuclear Information System (INIS)

    Amor, Nadia

    2012-01-01

    Since their discovery in the middle of the last century, Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI) have become an important and very versatile tool in industry, medicine, and basic research. The aim of this work is to explore possible improvements and new applications of NMR methods. First, a recently introduced excitation NMR pulse sequence, termed Frank sequence excitation, which allows for significant reduction of rf-excitation power, is systematically analyzed and compared to conventional NMR in detail. Furthermore, its feasibility for MRI is investigated and advantages as well as drawbacks in comparison to standard MRI are discussed. The second part focuses on new biomedical applications of hyperpolarized (HP) 129 Xe which not only offers a signal enhancement of several orders of magnitude but also provides new contrast mechanisms. A setup for continuous dissolution of HP 129 Xe gas into blood and other fluids is optimized and analyzed quantitatively by NMR and MRI. On the basis of these results, blood-dissolved HP 129 Xe is used to investigate blood-gas dynamics, as well as the rheological behavior of blood.

  20. Novel methods and applications of NMR and MRI. Low-power RF excitation and hyperpolarized Xenon-129

    Energy Technology Data Exchange (ETDEWEB)

    Amor, Nadia

    2012-07-01

    Since their discovery in the middle of the last century, Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI) have become an important and very versatile tool in industry, medicine, and basic research. The aim of this work is to explore possible improvements and new applications of NMR methods. First, a recently introduced excitation NMR pulse sequence, termed Frank sequence excitation, which allows for significant reduction of rf-excitation power, is systematically analyzed and compared to conventional NMR in detail. Furthermore, its feasibility for MRI is investigated and advantages as well as drawbacks in comparison to standard MRI are discussed. The second part focuses on new biomedical applications of hyperpolarized (HP) {sup 129}Xe which not only offers a signal enhancement of several orders of magnitude but also provides new contrast mechanisms. A setup for continuous dissolution of HP {sup 129}Xe gas into blood and other fluids is optimized and analyzed quantitatively by NMR and MRI. On the basis of these results, blood-dissolved HP {sup 129}Xe is used to investigate blood-gas dynamics, as well as the rheological behavior of blood.

  1. Scintillation efficiency of nuclear recoil in liquid xenon

    CERN Document Server

    Arneodo, F; Badertscher, A; Benetti, P; Bernardini, E; Bettini, A; Borio di Tigliole, A A; Brunetti, R; Bueno, A G; Calligarich, E; Campanelli, M; Carpanese, C; Cavalli, D; Cavanna, F; Cennini, P; Centro, Sandro; Cesana, A; Cline, D; De Mitri, I; Dolfini, R; Ferrari, A; Gigli-Berzolari, A; Matthey, C; Mauri, F; Mazza, D; Mazzone, L; Meng, G; Montanari, C; Nurzia, G; Otwinowski, S; Palamara, O; Pascoli, D; Pepato, Adriano; Petrera, S; Periale, L; Piano Mortari, G; Piazzoli, A; Picchi, P; Pietropaolo, F; Rancati, T; Rappoldi, A; Raselli, G L; Rebuzzi, D; Revol, Jean Pierre Charles; Rico, J; Rossella, M; Rossi, C; Rubbia, André; Rubbia, Carlo; Sala, P; Scannicchio, D A; Sergiampietri, F; Suzuki, S; Terrani, M; Tian, W; Ventura, Sandro; Vignoli, C; Wang, H; Woo, J; Xu, Z

    2000-01-01

    We present the results of a test done with a Liquid Xenon (LXe) detector for 'Dark Matter' search, exposed to a neutron beam to produce nuclear recoil events simulating those which would be generated by WIMP's elastic scattering. The aim of the experiment was to measure directly the scintillation efficiency of nuclear recoil. The nuclear recoil considered in the test was in the tens of keV range. The ratio of measured visible energy over the true recoil energy was evaluated to be about 20%, in good agreement with the theoretical predictions.

  2. Visualize Diffusion Map of COPD Rat with Hyperpolarized Xenon MRI%超极化Xenon对慢阻肺的可视化加权成像

    Institute of Scientific and Technical Information of China (English)

    阮伟伟; 钟俭平; 韩叶清; 孙献平; 叶朝辉; 周欣

    2015-01-01

    Hyperpolarized3He or129Xe diffusion MRI has been demonstrated as a promising technique for the detection of microanatomical changes in chronic obstructive pulmonary disease (COPD). Compared with 3He,129Xe is more available for the potential clinical applications. However, the measurement of129Xe apparent diffusion coefficient (ADC) possesses more challenges due to the relevant low gyromagnetic ratio and spin polarization. In this present study, a singleb value (b = 14 s/cm2) diffusion-weighted hyperpolarized129Xe MRI sequence was used to image a balloon phantom, healthy rats, and the COPD rats, respectively. All COPD rats were induced by second-hand smoke and lipopolysaccharide (LPS). The lung129XeADCmaps were obtained on a 7 T MRI scanner. The mean lung parenchymal129XeADCswere 0.044 22±0.002 9 and 0.042 34±0.002 3 cm2/s (Δ = 0.8/1.2 ms) for the COPD rats, which showed significant increasements in comparison with healthy ones (0.037 7±0.002 3 and 0.036 7±0.001 3 cm2/s). Furthermore, the correspondingADChistogram of the COPD rats exhibited a broader distribution as compared with the healthy ones. Our experiments demonstrated that the alveolar airspace enlargement in the COPD rats are able to be quantitatively evaluated by hyperpolarized xenon diffusion-weighted MRI.%超极化气体3He或者129Xe扩散加权成像已经被证明了能够有效检测慢性阻塞性肺部疾病(COPD)中肺部微结构的改变.相比于3He,129Xe更便宜而且更容易获得,但是129Xe成像中较低的信噪比致使129Xe 的肺部表面扩散系数(ADC)的测量面临着许多困难.在该研究中,为了得到更高的图像信噪比,作者对气球模型,健康大鼠和COPD大鼠进行了单个b值(14 cm2/s)的扩散加权超极化129Xe磁共振成像(MRI).所有的COPD模型大鼠是通过烟熏和注射内毒素(LPS)进行诱导得到的.在7 T磁共振成像仪上面获得了大鼠肺实质的超极化129Xe ADC值分布图.COPD大鼠肺实质的129Xe

  3. Measurement of xenon reactivity in the reactor of the nuclear ship 'MUTSU'

    International Nuclear Information System (INIS)

    Itagaki, Masafumi; Miyoshi, Yoshinori; Gakuhari, Kazuhiko; Okada, Noboru.

    1993-01-01

    This report deals with the measurement of reactivity changes caused by the increase and decrease of xenon concentration in the reactor core of the nuclear ship 'MUTSU' after a change from long-term operation at 70 % to zero power. The change in xenon reactivity was compensated by control-rod movements and the compensated reactivity was measured using a digital reactivity meter. The xenon override peak was recognized five and half hours after the start of power reduction. The equilibrium and peak reactivities of xenon were estimated by reading the initial and peak values of a theoretical curve which was fitted to the measured variation in xenon reactivity. The xenon reactivity results obtained by the present method can be considered to be accurate since no control-rod worth data were used and the measured quantity was the reactivity itself. (author)

  4. Transportable hyperpolarized metabolites

    Science.gov (United States)

    Ji, Xiao; Bornet, Aurélien; Vuichoud, Basile; Milani, Jonas; Gajan, David; Rossini, Aaron J.; Emsley, Lyndon; Bodenhausen, Geoffrey; Jannin, Sami

    2017-01-01

    Nuclear spin hyperpolarization of 13C-labelled metabolites by dissolution dynamic nuclear polarization can enhance the NMR signals of metabolites by several orders of magnitude, which has enabled in vivo metabolic imaging by MRI. However, because of the short lifetime of the hyperpolarized magnetization (typically <1 min), the polarization process must be carried out close to the point of use. Here we introduce a concept that markedly extends hyperpolarization lifetimes and enables the transportation of hyperpolarized metabolites. The hyperpolarized sample can thus be removed from the polarizer and stored or transported for use at remote MRI or NMR sites. We show that hyperpolarization in alanine and glycine survives 16 h storage and transport, maintaining overall polarization enhancements of up to three orders of magnitude. PMID:28072398

  5. Characterization of Chemical Exchange Using Relaxation Dispersion of Hyperpolarized Nuclear Spins.

    Science.gov (United States)

    Liu, Mengxiao; Kim, Yaewon; Hilty, Christian

    2017-09-05

    Chemical exchange phenomena are ubiquitous in macromolecules, which undergo conformational change or ligand complexation. NMR relaxation dispersion (RD) spectroscopy based on a Carr-Purcell-Meiboom-Gill pulse sequence is widely applied to identify the exchange and measure the lifetime of intermediate states on the millisecond time scale. Advances in hyperpolarization methods improve the applicability of NMR spectroscopy when rapid acquisitions or low concentrations are required, through an increase in signal strength by several orders of magnitude. Here, we demonstrate the measurement of chemical exchange from a single aliquot of a ligand hyperpolarized by dissolution dynamic nuclear polarization (D-DNP). Transverse relaxation rates are measured simultaneously at different pulsing delays by dual-channel 19 F NMR spectroscopy. This two-point measurement is shown to allow the determination of the exchange term in the relaxation rate expression. For the ligand 4-(trifluoromethyl)benzene-1-carboximidamide binding to the protein trypsin, the exchange term is found to be equal within error limits in neutral and acidic environments from D-DNP NMR spectroscopy, corresponding to a pre-equilibrium of trypsin deprotonation. This finding illustrates the capability for determination of binding mechanisms using D-DNP RD. Taking advantage of hyperpolarization, the ligand concentration in the exchange measurements can reach on the order of tens of μM and protein concentration can be below 1 μM, i.e., conditions typically accessible in drug discovery.

  6. Hyperpolarized 129Xe as an NMR probe for functional studies

    International Nuclear Information System (INIS)

    Wolber, J.

    2000-01-01

    The nuclear spin polarization of 129 Xe can be enhanced by several orders of magnitude using optical pumping techniques, resulting in a dramatic enhancement of the 129 Xe Nuclear Magnetic Resonance (NMR) signal. The 'hyperpolarized' gas can be used for Magnetic Resonance Imaging (MRI) of the void spaces of the lungs after introduction of the gas into the respiratory system. Furthermore, the high solubility of xenon in blood and lipids suggests the use of 129 Xe NMR for studying blood flow, permeability, perfusion and blood volume. Hyperpolarized 129 Xe MRI has the potential of combining the high sensitivity and functional information of radioactive tracer studies with the high spatial and temporal resolution of MRI. The spin-lattice relaxation time T 1 of 129 Xe in blood determines the loss of polarization during transit from the lungs to the tissue of interest. A difference in the relaxation times of xenon in oxygenated and deoxygenated blood could be used as a contrast mechanism in functional Magnetic Resonance Imaging (fMRI). In this thesis, the hyperpolarized 129 Xe T 1 in human blood is measured in vitro as a function of blood oxygenation, and the relevant relaxation mechanisms are discussed. A new and unexpected finding is that the hyperpolarized 129 Xe NMR spectrum in blood is highly sensitive to blood oxygenation. Therefore, hyperpolarized 129 Xe NMR provides a powerful means of measuring blood oxygenation quantitatively and non-invasively. The interaction of xenon with hemoglobin is responsible for an oxygen-dependent shift of the 129 Xe NMR resonance of xenon in red blood cells. Injection delivery of hyperpolarized 129 Xe in solution could be a more efficient method of administrating the gas for functional NMR studies. For this purpose, suitable biocompatible carrier media have been studied. In particular, the use of perfluorocarbon emulsions, which are already in use as blood substitutes, as delivery media for hyperpolarized 129 Xe has been investigates

  7. T1 nuclear magnetic relaxation dispersion of hyperpolarized sodium and cesium hydrogencarbonate-13 C.

    Science.gov (United States)

    Martínez-Santiesteban, Francisco M; Dang, Thien Phuoc; Lim, Heeseung; Chen, Albert P; Scholl, Timothy J

    2017-09-01

    In vivo pH mapping in tissue using hyperpolarized hydrogencarbonate- 13 C has been proposed as a method to study tumor growth and treatment and other pathological conditions related to pH changes. The finite spin-lattice relaxation times (T 1 ) of hyperpolarized media are a significant limiting factor for in vivo imaging. Relaxation times can be measured at standard magnetic fields (1.5 T, 3.0 T etc.), but no such data are available at low fields, where T 1 values can be significantly shorter. This information is required to determine the potential loss of polarization as the agent is dispensed and transported from the polarizer to the MRI scanner. The purpose of this study is to measure T 1 dispersion from low to clinical magnetic fields (0.4 mT to 3.0 T) of different hyperpolarized hydrogencarbonate formulations previously proposed in the literature for in vivo pH measurements. 13 C-enriched cesium and sodium hydrogencarbonate preparations were hyperpolarized using dynamic nuclear polarization, and the T 1 values of different samples were measured at different magnetic field strengths using a fast field-cycling relaxometer and a 3.0 T clinical MRI system. The effects of deuterium oxide as a dissolution medium for sodium hydrogencarbonate were also analyzed. This study finds that the cesium formulation has slightly shorter T 1 values compared with the sodium preparation. However, the higher solubility of cesium hydrogencarbonate- 13 C means it can be polarized at greater concentration, using less trityl radical than sodium hydrogencarbonate- 13 C. This study also establishes that the preparation and handling of sodium hydrogencarbonate formulations in relation to cesium hydrogencarbonate is more difficult, due to the higher viscosity and lower achievable concentrations, and that deuterium oxide significantly increases the T 1 of sodium hydrogencarbonate solutions. Finally, this work also investigates the influence of pH on the spin-lattice relaxation of cesium

  8. Nuclear recoil energy scale in liquid xenon with application to the direct detection of dark matter

    International Nuclear Information System (INIS)

    Sorensen, Peter; Dahl, Carl Eric

    2011-01-01

    We show for the first time that the quenching of electronic excitation from nuclear recoils in liquid xenon is well-described by Lindhard theory, if the nuclear recoil energy is reconstructed using the combined (scintillation and ionization) energy scale proposed by Shutt et al. We argue for the adoption of this perspective in favor of the existing preference for reconstructing nuclear recoil energy solely from primary scintillation. We show that signal partitioning into scintillation and ionization is well described by the Thomas-Imel box model. We discuss the implications for liquid xenon detectors aimed at the direct detection of dark matter.

  9. Cluster formation restricts dynamic nuclear polarization of xenon in solid mixtures

    DEFF Research Database (Denmark)

    Kuzma, N. N.; Pourfathi, M.; Kara, H.

    2012-01-01

    During dynamic nuclear polarization (DNP) at 1.5 K and 5 T, Xe-129 nuclear magnetic resonance (NMR) spectra of a homogeneous xenon/1-propanol/trityl-radical solid mixture exhibit a single peak, broadened by H-1 neighbors. A second peak appears upon annealing for several hours at 125 K. Its...

  10. The physical and physiological aspects of xenon isotopes in nuclear medical applicants

    International Nuclear Information System (INIS)

    Bolmsjoe, M.

    1981-11-01

    A method for trapping radioactive xenon waste from nuclear medical departments has been investigated. Adsorption of xenon acivitaded charcoal was found to be an efficient trapping method. A large gain in capacity was found when the trap was refrigerated, and permitted a large number of patient investigations before break-through of xenon occurred. By heating charcoal traps to 250-350 degrees C, adsorbed xenon gas is freed and is thus made available for re-use. A technique for room-air monitoring of xenon-leakage from patient investigations is described, where the room-air is continously pumped through a small charcoal filter, mounted close to a detector. The low gammaenergy of Xe-133, 81 keV, introduces problems for in vivo measurements due to the small differences in the energies of the primary and Compton-scattered photons. Influence of scatter and of hemispheric cross-talk was studied for cerebral blood-flow measurements. It was shown that substantial artefacts are introduced in the calculation of regional gray matter flow. The applicability of the xenon-washout technique for liver blood-flow measurements in rat was investigated. (author)

  11. Unitary theory of xenon instability in nuclear thermal reactors - 1. Reactor at 'zero power'

    International Nuclear Information System (INIS)

    Novelli, A.

    1982-01-01

    The question of nuclear thermal-reactor instability against xenon oscillations is widespread in the literature, but most theories, concerned with such an argument, contradict each other and, above all, they conflict with experimentally-observed instability at very low reactor power, i.e. without any power feedback. It is shown that, in any nuclear thermal reactor, xenon instability originates at very low power levels, and a very general stability condition is deduced by an extension of the rigorous, simple and powerful reduction of the Nyquist criterion, first performed by F. Storrer. (author)

  12. When the dust settles: stable xenon isotope constraints on the formation of nuclear fallout

    International Nuclear Information System (INIS)

    Cassata, W.S.; Prussin, S.G.; Knight, K.B.; Hutcheon, I.D.; Isselhardt, B.H.; Renne, P.R.

    2014-01-01

    Nuclear weapons represent one of the most immediate threats of mass destruction. In the event that a procured or developed nuclear weapon is detonated in a populated metropolitan area, timely and accurate nuclear forensic analysis and fallout modeling would be needed to support attribution efforts and hazard assessments. Here we demonstrate that fissiogenic xenon isotopes retained in radioactive fallout generated by a nuclear explosion provide unique constraints on (1) the timescale of fallout formation, (2) chemical fractionation that occurs when fission products and nuclear fuel are incorporated into fallout, and (3) the speciation of fission products in the fireball. Our data suggest that, in near surface nuclear tests, the presence of a significant quantity of metal in a device assembly, combined with a short time allowed for mixing with the ambient atmosphere (seconds), may prevent complete oxidation of fission products prior to their incorporation into fallout. Xenon isotopes thus provide a window into the chemical composition of the fireball in the seconds that follow a nuclear explosion, thereby improving our understanding of the physical and thermo-chemical conditions under which fallout forms. - Highlights: • Radioactive fallout generated by nuclear explosions contains fissiogenic xenon isotopes. • Xe isotopes provide constraints on timescales of fallout formation and the speciation of fission products in the fireball. • Our data indicate that macroscopic fallout forms rapidly (<3 s). • Chemical fractionation trends suggest that fission products may not have been fully oxidized prior to incorporation

  13. Liquid xenon in nuclear medicine: state-of-the-art and the PETALO approach

    Science.gov (United States)

    Ferrario, P.

    2018-01-01

    Liquid xenon has several attractive features, which make it suitable for applications to nuclear medicine, such as high scintillation yield and fast scintillation decay time, better than currently used crystals. Since the '90s, several attempts have been made to build Positron Emission Tomography scanners based on liquid xenon, which can be divided into two different approaches: on one hand, the detection of the ionization charge in TPCs, and, on the other one, the detection of scintillation light with photomultipliers. PETALO (Positron Emission Tof Apparatus with Liquid xenOn) is a novel concept, which combines liquid xenon scintillating cells and silicon photomultipliers for the readout. A first Monte Carlo investigation has pointed out that this technology would provide an excellent intrinsic time resolution, which makes it possible to measure the Time-Of-Flight with high efficiency. Also, the transparency of liquid xenon to UV and blue wavelengths opens the possibility of exploiting both scintillation and Cherenkov light for a high-sensitivity TOF-PET.

  14. Pairwise additivity in the nuclear magnetic resonance interactions of atomic xenon.

    Science.gov (United States)

    Hanni, Matti; Lantto, Perttu; Vaara, Juha

    2009-04-14

    Nuclear magnetic resonance (NMR) of atomic (129/131)Xe is used as a versatile probe of the structure and dynamics of various host materials, due to the sensitivity of the Xe NMR parameters to intermolecular interactions. The principles governing this sensitivity can be investigated using the prototypic system of interacting Xe atoms. In the pairwise additive approximation (PAA), the binary NMR chemical shift, nuclear quadrupole coupling (NQC), and spin-rotation (SR) curves for the xenon dimer are utilized for fast and efficient evaluation of the corresponding NMR tensors in small xenon clusters Xe(n) (n = 2-12). If accurate, the preparametrized PAA enables the analysis of the NMR properties of xenon clusters, condensed xenon phases, and xenon gas without having to resort to electronic structure calculations of instantaneous configurations for n > 2. The binary parameters for Xe(2) at different internuclear distances were obtained at the nonrelativistic Hartree-Fock level of theory. Quantum-chemical (QC) calculations at the corresponding level were used to obtain the NMR parameters of the Xe(n) (n = 2-12) clusters at the equilibrium geometries. Comparison of PAA and QC data indicates that the direct use of the binary property curves of Xe(2) can be expected to be well-suited for the analysis of Xe NMR in the gaseous phase dominated by binary collisions. For use in condensed phases where many-body effects should be considered, effective binary property functions were fitted using the principal components of QC tensors from Xe(n) clusters. Particularly, the chemical shift in Xe(n) is strikingly well-described by the effective PAA. The coordination number Z of the Xe site is found to be the most important factor determining the chemical shift, with the largest shifts being found for high-symmetry sites with the largest Z. This is rationalized in terms of the density of virtual electronic states available for response to magnetic perturbations.

  15. Surface Coatings as Xenon Diffusion Barriers for Improved Detection of Clandestine Nuclear Explosions

    OpenAIRE

    Bläckberg, Lisa

    2014-01-01

    This thesis investigates surface coatings as xenon diffusion barriers on plastic scintillators. The motivation for the work is improved radioxenon detection systems, used within the verification regime of the Comprehensive Nuclear-Test-Ban Treaty (CTBT). One type of radioxenon detection systems used in this context is the Swedish SAUNA system. This system uses a cylindrical plastic scintillator cell to measure the beta decay from radioxenon isotopes. The detector cell also acts as a container...

  16. Surface coatings as xenon diffusion barriers on plastic scintillators : Improving Nuclear-Test-Ban Treaty verification

    OpenAIRE

    Bläckberg, Lisa

    2011-01-01

    This thesis investigates the ability of transparent surface coatings to reduce xenon diffusion into plastic scintillators. The motivation for the work is improved radioxenon monitoring equipment, used with in the framework of the verification regime of the Comprehensive Nuclear-Test-Ban Treaty. A large part of the equipment used in this context incorporates plastic scintillators which are in direct contact with the radioactive gas to be detected. One problem with such setup is that radioxenon...

  17. Xenon monitoring and the Comprehensive Nuclear-Test-Ban Treaty

    Energy Technology Data Exchange (ETDEWEB)

    Bowyer, Theodore W. [Nuclear Explosion Monitoring Program, Pacific Northwest National Laboratory, Richland, Washington 99352 (United States)

    2014-05-09

    How do you monitor (verify) a CTBT? It is a difficult challenge to monitor the entire world for nuclear tests, regardless of size. Nuclear tests 'normally' occur underground, above ground or underwater. Setting aside very small tests (let's limit our thinking to 1 kiloton or more), nuclear tests shake the ground, emit large amounts of radioactivity, and make loud noises if in the atmosphere (or hydroacoustic waves if underwater)

  18. Robust nonlinear model predictive control for nuclear power plants in load following operations with bounded xenon oscillations

    International Nuclear Information System (INIS)

    Eliasi, H.; Menhaj, M.B.; Davilu, H.

    2011-01-01

    Research highlights: → In this work, a robust nonlinear model predictive control algorithm is developed. → This algorithm is applied to control the power level for load following. → The state constraints are imposed on the predicted trajectory during optimization. → The xenon oscillations are the main constraint for the load following problem. → In this algorithm, xenon oscillations are bounded within acceptable limits. - Abstract: One of the important operations in nuclear power plants is load-following in which imbalance of axial power distribution induces xenon oscillations. These oscillations must be maintained within acceptable limits otherwise the nuclear power plant could become unstable. Therefore, bounded xenon oscillation considered to be a constraint for the load-following operation. In this paper, a robust nonlinear model predictive control for the load-following operation problem is proposed that ensures xenon oscillations are kept bounded within acceptable limits. The proposed controller uses constant axial offset (AO) strategy to maintain xenon oscillations to be bounded. The constant AO is a robust state constraint for load-following problem. The controller imposes restricted state constraints on the predicted trajectory during optimization which guarantees robust satisfaction of state constraints without restoring to a min-max optimization problem. Simulation results show that the proposed controller for the load-following operation is so effective so that the xenon oscillations kept bounded in the given region.

  19. Control of xenon spatial oscillations during load follow of nuclear reactor via robust servo systems

    International Nuclear Information System (INIS)

    Ukai, Hiroyuki; Yada, Yukihiro; Iwazumi, Tetsuo; Morita, Yoshifumi.

    1990-01-01

    This paper investigates the control problem of xenon spatial oscillations in the axial direction during load following operations of a nuclear reactor. The system model is described by a one-group diffusion equation with xenon and power feedbacks and iodine-xenon dynamic equations and controlled by full-length and part-length control rods. In order to achieve the control purpose we formulate the control model as the design problem of robust servo systems for distributed parameter reactor systems. Hence the total thermal power and the axial offset are chosen as outputs to be controlled. The control law is designed based upon finite-dimensional systems which are constructed by linearizing around steady states, approximating by the Galerkin approximate method and reducing dimensions via the singular perturbation method. From a computational point of view a simple computational algorithm to obtain an approximate solution of the steady state neutron balance is developed via the perturbation method. Some results of numerical simulations are represented to show effectiveness of the theory developed in this paper. Particularly it is shown that the designed servo systems are robust against model errors with the linearization and the model truncation. (author)

  20. Xenon spatial oscillation in nuclear power reactors:an analytical approach through non linear modal analysis

    International Nuclear Information System (INIS)

    Suarez Antola, R.

    2005-01-01

    It was proponed recently to apply an extension of Lyapunov's first method to the non-linear regime, known as non-linear modal analysis (NMA), to the study of space-time problems in nuclear reactor kinetics, nuclear power plant dynamics and nuclear power plant instrumentation and control(1). The present communication shows how to apply NMA to the study of Xenon spatial oscillations in large nuclear reactors. The set of non-linear modal equations derived by J. Lewins(2) for neutron flux, Xenon concentration and Iodine concentration are discussed, and a modified version of these equations is taken as a starting point. Using the methods of singular perturbation theory a slow manifold is constructed in the space of mode amplitudes. This allows the reduction of the original high dimensional dynamics to a low dimensional one. It is shown how the amplitudes of the first mode for neutron flux field, temperature field and concentrations of Xenon and Iodine fields can have a stable steady state value while the corresponding amplitudes of the second mode oscillates in a stable limit cycle. The extrapolated dimensions of the reactor's core are used as bifurcation parameters. Approximate analytical formulae are obtained for the critical values of this parameters( below which the onset of oscillations is produced), for the period and for the amplitudes of the above mentioned oscillations. These results are applied to the discussion of neutron flux and temperature excursions in critical locations of the reactor's core. The results of NMA can be validated from the results obtained applying suitable computer codes, using homogenization theory(3) to link the complex heterogeneous model of the codes with the simplified mathematical model used for NMA

  1. Unitary theory of xenon instability in nuclear thermal reactors - 1. Reactor at 'zero power'

    Energy Technology Data Exchange (ETDEWEB)

    Novelli, A. (Politecnico di Milano (Italy). Centro Studi Nucleari E. Fermi)

    1982-01-01

    The question of nuclear thermal-reactor instability against xenon oscillations is widespread in the literature, but most theories, concerned with such an argument, contradict each other and, above all, they conflict with experimentally-observed instability at very low reactor power, i.e. without any power feedback. It is shown that, in any nuclear thermal reactor, xenon instability originates at very low power levels, and a very general stability condition is deduced by an extension of the rigorous, simple and powerful reduction of the Nyquist criterion, first performed by F. Storrer.

  2. Sliding Mode Control for Pressurized-Water Nuclear Reactors in load following operations with bounded xenon oscillations

    International Nuclear Information System (INIS)

    Ansarifar, G.R.; Saadatzi, S.

    2015-01-01

    Highlights: • We present SMC which is a robust nonlinear controller to control the PWR power. • Xenon oscillations are kept bounded within acceptable limits. • The stability analysis has been based on Lyapunov approach. • Simulation results indicate the high performance of this new control. - Abstract: One of the important operations in nuclear power plants is load-following in which imbalance of axial power distribution induces xenon oscillations. These oscillations must be maintained within acceptable limits otherwise the nuclear power plant could become unstable. Therefore, bounded xenon oscillation considered to be a constraint for the load-following operation. In this paper, sliding mode control (SMC) which is a robust nonlinear controller is designed to control the Pressurized-Water Nuclear Reactor (PWR) power for the load-following operation problem that ensures xenon oscillations are kept bounded within acceptable limits. The proposed controller uses constant axial offset (AO) strategy to maintain xenon oscillations to be bounded. The constant AO is a robust state constraint for load-following problem. The reactor core is simulated based on the two-point nuclear reactor model and one delayed neutron group. The stability analysis is given by means Lyapunov approach, thus the control system is guaranteed to be stable within a large range. The employed method is easy to implement in practical applications and moreover, the sliding mode control exhibits the desired dynamic properties during the entire output-tracking process independent of perturbations. Simulation results are presented to demonstrate the effectiveness of the proposed controller in terms of performance, robustness and stability. Results show that the proposed controller for the load-following operation is sufficiently effective so that the xenon oscillations are kept bounded in the considered region

  3. The total release of xenon-133 from the Fukushima Dai-ichi nuclear power plant accident

    International Nuclear Information System (INIS)

    Stohl, Andreas; Seibert, Petra; Wotawa, Gerhard

    2012-01-01

    The accident at the Fukushima Dai-ichi nuclear power plant (FD-NPP) on 11 March 2011 released large amounts of radioactivity into the atmosphere. We determine the total emission of the noble gas xenon-133 ( 133 Xe) using global atmospheric concentration measurements. For estimating the emissions, we used three different methods: (i) using a purely observation-based multi-box model, (ii) comparisons of dispersion model results driven with GFS meteorological data with the observation data, and (iii) such comparisons with the dispersion model driven by ECMWF data. From these three methods, we have obtained total 133 Xe releases from FD-NPP of (i) 16.7 ± 1.9 EBq, (ii) 14.2 ± 0.8 EBq, and (iii) 19.0 ± 3.4 EBq, respectively. These values are substantially larger than the entire 133 Xe inventory of FD-NPP of about 12.2 EBq derived from calculations of nuclear fuel burn-up. Complete release of the entire 133 Xe inventory of FD-NPP and additional release of 133 Xe due to the decay of iodine-133 ( 133 I), which can add another 2 EBq to the 133 Xe FD-NPP inventory, is required to explain the atmospheric observations. Two of our three methods indicate even higher emissions, but this may not be a robust finding given the differences between our estimates. - Highlights: ► We determine the total release of xenon-133 from the Fukushima nuclear accident. ► We used global measurements and a box model, as well as dispersion model estimates. ► Total 133 Xe release is about 14.2-19 EBq, more than Fukushima 133 Xe inventory. ► Additional release of iodine-133 and decay into 133 Xe needed to explain results.

  4. Signal yields of keV electronic recoils and their discrimination from nuclear recoils in liquid xenon

    Science.gov (United States)

    Aprile, E.; Aalbers, J.; Agostini, F.; Alfonsi, M.; Amaro, F. D.; Anthony, M.; Arneodo, F.; Barrow, P.; Baudis, L.; Bauermeister, B.; Benabderrahmane, M. L.; Berger, T.; Breur, P. A.; Brown, A.; Brown, E.; Bruenner, S.; Bruno, G.; Budnik, R.; Bütikofer, L.; Calvén, J.; Cardoso, J. M. R.; Cervantes, M.; Cichon, D.; Coderre, D.; Colijn, A. P.; Conrad, J.; Cussonneau, J. P.; Decowski, M. P.; de Perio, P.; di Gangi, P.; di Giovanni, A.; Diglio, S.; Eurin, G.; Fei, J.; Ferella, A. D.; Fieguth, A.; Fulgione, W.; Gallo Rosso, A.; Galloway, M.; Gao, F.; Garbini, M.; Geis, C.; Goetzke, L. W.; Grandi, L.; Greene, Z.; Grignon, C.; Hasterok, C.; Hogenbirk, E.; Howlett, J.; Itay, R.; Kaminsky, B.; Kazama, S.; Kessler, G.; Kish, A.; Landsman, H.; Lang, R. F.; Lellouch, D.; Levinson, L.; Lin, Q.; Lindemann, S.; Lindner, M.; Lombardi, F.; Lopes, J. A. M.; Mahlstedt, J.; Manfredini, A.; Maris, I.; Marrodán Undagoitia, T.; Masbou, J.; Massoli, F. V.; Masson, D.; Mayani, D.; Messina, M.; Micheneau, K.; Molinario, A.; Morâ, K.; Murra, M.; Naganoma, J.; Ni, K.; Oberlack, U.; Pakarha, P.; Pelssers, B.; Persiani, R.; Piastra, F.; Pienaar, J.; Pizzella, V.; Piro, M.-C.; Plante, G.; Priel, N.; Ramírez García, D.; Rauch, L.; Reichard, S.; Reuter, C.; Rizzo, A.; Rupp, N.; Saldanha, R.; Dos Santos, J. M. F.; Sartorelli, G.; Scheibelhut, M.; Schindler, S.; Schreiner, J.; Schumann, M.; Scotto Lavina, L.; Selvi, M.; Shagin, P.; Shockley, E.; Silva, M.; Simgen, H.; Sivers, M. V.; Stein, A.; Thers, D.; Tiseni, A.; Trinchero, G.; Tunnell, C.; Vargas, M.; Wang, H.; Wang, Z.; Wei, Y.; Weinheimer, C.; Wittweg, C.; Wulf, J.; Ye, J.; Zhang, Y.; Zhu, T.; Xenon Collaboration

    2018-05-01

    We report on the response of liquid xenon to low energy electronic recoils below 15 keV from beta decays of tritium at drift fields of 92 V /cm , 154 V /cm and 366 V /cm using the XENON100 detector. A data-to-simulation fitting method based on Markov Chain Monte Carlo is used to extract the photon yields and recombination fluctuations from the experimental data. The photon yields measured at the two lower fields are in agreement with those from literature; additional measurements at a higher field of 366 V /cm are presented. The electronic and nuclear recoil discrimination as well as its dependence on the drift field and photon detection efficiency are investigated at these low energies. The results provide new measurements in the energy region of interest for dark matter searches using liquid xenon.

  5. A magnetic tunnel to shelter hyperpolarized fluids

    Energy Technology Data Exchange (ETDEWEB)

    Milani, Jonas, E-mail: jonas.milani@epfl.ch; Vuichoud, Basile; Bornet, Aurélien; Miéville, Pascal; Mottier, Roger [Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), Batochime, CH-1015 Lausanne (Switzerland); Jannin, Sami [Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), Batochime, CH-1015 Lausanne (Switzerland); Bruker BioSpin AG, Industriestrasse 26, CH-8117 Fällanden (Switzerland); Bodenhausen, Geoffrey [Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), Batochime, CH-1015 Lausanne (Switzerland); Département de Chimie, École Normale Supérieure-PSL Research University, 24 rue Lhomond, F-75005 Paris (France); Sorbonne Universités, UPMC Univ Paris 06, LBM, 4 place Jussieu, F-75005 Paris (France); CNRS, UMR 7203 LBM, F-75005 Paris (France)

    2015-02-15

    To shield solutions carrying hyperpolarized nuclear magnetization from rapid relaxation during transfer through low fields, the transfer duct can be threaded through an array of permanent magnets. The advantages are illustrated for solutions containing hyperpolarized {sup 1}H and {sup 13}C nuclei in a variety of molecules.

  6. A magnetic tunnel to shelter hyperpolarized fluids

    International Nuclear Information System (INIS)

    Milani, Jonas; Vuichoud, Basile; Bornet, Aurélien; Miéville, Pascal; Mottier, Roger; Jannin, Sami; Bodenhausen, Geoffrey

    2015-01-01

    To shield solutions carrying hyperpolarized nuclear magnetization from rapid relaxation during transfer through low fields, the transfer duct can be threaded through an array of permanent magnets. The advantages are illustrated for solutions containing hyperpolarized 1 H and 13 C nuclei in a variety of molecules

  7. Nuclear recoil scintillation and ionisation yields in liquid xenon from ZEPLIN-III data

    Energy Technology Data Exchange (ETDEWEB)

    Horn, M., E-mail: m.horn@imperial.ac.uk [High Energy Physics group, Blackett Laboratory, Imperial College London (United Kingdom); Belov, V.A.; Akimov, D.Yu. [Institute for Theoretical and Experimental Physics, Moscow (Russian Federation); Araujo, H.M. [High Energy Physics group, Blackett Laboratory, Imperial College London (United Kingdom); Barnes, E.J. [School of Physics and Astronomy, SUPA University of Edinburgh (United Kingdom); Burenkov, A.A. [Institute for Theoretical and Experimental Physics, Moscow (Russian Federation); Chepel, V. [LIP-Coimbra and Department of Physics of the University of Coimbra (Portugal); Currie, A. [High Energy Physics group, Blackett Laboratory, Imperial College London (United Kingdom); Edwards, B. [Particle Physics Department, STFC Rutherford Appleton Laboratory, Chilton (United Kingdom); Ghag, C.; Hollingsworth, A. [School of Physics and Astronomy, SUPA University of Edinburgh (United Kingdom); Kalmus, G.E. [Particle Physics Department, STFC Rutherford Appleton Laboratory, Chilton (United Kingdom); Kobyakin, A.S.; Kovalenko, A.G. [Institute for Theoretical and Experimental Physics, Moscow (Russian Federation); Lebedenko, V.N. [High Energy Physics group, Blackett Laboratory, Imperial College London (United Kingdom); Lindote, A. [LIP-Coimbra and Department of Physics of the University of Coimbra (Portugal); Particle Physics Department, STFC Rutherford Appleton Laboratory, Chilton (United Kingdom); Lopes, M.I. [LIP-Coimbra and Department of Physics of the University of Coimbra (Portugal); Luescher, R.; Majewski, P. [Particle Physics Department, STFC Rutherford Appleton Laboratory, Chilton (United Kingdom); Murphy, A.StJ. [School of Physics and Astronomy, SUPA University of Edinburgh (United Kingdom)

    2011-11-24

    Scintillation and ionisation yields for nuclear recoils in liquid xenon above 10 keV{sub nr} (nuclear recoil energy) are deduced from data acquired using broadband Am-Be neutron sources. The nuclear recoil data from several exposures to two sources were compared to detailed simulations. Energy-dependent scintillation and ionisation yields giving acceptable fits to the data were derived. Efficiency and resolution effects are treated using a light collection Monte Carlo, measured photomultiplier response profiles and hardware trigger studies. A gradual fall in scintillation yield below {approx}40 keV{sub nr} is found, together with a rising ionisation yield; both are in agreement with the latest independent measurements. The analysis method is applied to the most recent ZEPLIN-III data, acquired with a significantly upgraded detector and a precision-calibrated Am-Be source, as well as to the earlier data from the first run in 2008. A new method for deriving the recoil scintillation yield, which includes sub-threshold S1 events, is also presented which confirms the main analysis.

  8. NMR study of hyper-polarized 129Xe and applications to liquid-phase NMR experiments

    International Nuclear Information System (INIS)

    Marion, D.

    2008-07-01

    In liquid samples where both nuclear polarization and spin density are strong, the magnetization dynamics, which can be analysed by NMR (nuclear magnetic resonance) methods, is deeply influenced by the internal couplings induced by local dipolar fields. The present thesis describes some of the many consequences associated to the presence in the sample of concentrated xenon hyper-polarized by an optical pumping process. First, we deal with the induced modifications in frequency and line width of the proton and xenon spectra, then we present the results of SPIDER, a coherent polarization transfer experiment designed to enhance the polarization of protons, in order to increase their NMR signal level. A third part is dedicated to the description of the apparition of repeated chaotic maser emissions by un unstable xenon magnetization coupled to the detection coil tuned at the xenon Larmor frequency (here 138 MHz). In the last part, we present a new method allowing a better tuning of any NMR detection probe and resulting in sensible gains in terms of sensitivity and signal shaping. Finally, we conclude with a partial questioning of the classical relaxation theory in the specific field of highly polarized and concentrated spin systems in a liquid phase. (author)

  9. Innovative concept for a major breakthrough in atmospheric radioactive xenon detection for nuclear explosion monitoring

    International Nuclear Information System (INIS)

    Le Petit, G.; Cagniant, A.; Gross, P.; Achim, P.; Douysset, G.; Taffary, T.; Moulin, C.; Morelle, M.

    2013-01-01

    The verification regime of the comprehensive test ban treaty (CTBT) is based on a network of three different waveform technologies together with global monitoring of aerosols and noble gas in order to detect, locate and identify a nuclear weapon explosion down to 1 kt TNT equivalent. In case of a low intensity underground or underwater nuclear explosion, it appears that only radioactive gases, especially the noble gas which are difficult to contain, will allow identification of weak yield nuclear tests. Four radioactive xenon isotopes, 131m Xe, 133m Xe, 133 Xe and 135 Xe, are sufficiently produced in fission reactions and exhibit suitable half-lives and radiation emissions to be detected in atmosphere at low level far away from the release site. Four different monitoring CTBT systems, ARIX, ARSA, SAUNA, and SPALAX TM have been developed in order to sample and to measure them with high sensitivity. The latest developed by the French Atomic Energy Commission (CEA) is likely to be drastically improved in detection sensitivity (especially for the metastable isotopes) through a higher sampling rate, when equipped with a new conversion electron (CE)/X-ray coincidence spectrometer. This new spectrometer is based on two combined detectors, both exhibiting very low radioactive background: a well-type NaI(Tl) detector for photon detection surrounding a gas cell equipped with two large passivated implanted planar silicon chips for electron detection. It is characterized by a low electron energy threshold and a much better energy resolution for the CE than those usually measured with the existing CTBT equipments. Furthermore, the compact geometry of the spectrometer provides high efficiency for X-ray and for CE associated to the decay modes of the four relevant radioxenons. The paper focus on the design of this new spectrometer and presents spectroscopic performances of a prototype based on recent results achieved from both radioactive xenon standards and air sample

  10. UTEX modeling of xenon signature sensitivity to geology and explosion cavity characteristics following an underground nuclear explosion

    Science.gov (United States)

    Lowrey, J. D.; Haas, D.

    2013-12-01

    Underground nuclear explosions (UNEs) produce anthropogenic isotopes that can potentially be used in the verification component of the Comprehensive Nuclear-Test-Ban Treaty. Several isotopes of radioactive xenon gas have been identified as radionuclides of interest within the International Monitoring System (IMS) and in an On-Site Inspection (OSI). Substantial research has been previously undertaken to characterize the geologic and atmospheric mechanisms that can drive the movement of radionuclide gas from a well-contained UNE, considering both sensitivities on gas arrival time and signature variability of xenon due to the nature of subsurface transport. This work further considers sensitivities of radioxenon gas arrival time and signatures to large variability in geologic stratification and generalized explosion cavity characteristics, as well as compares this influence to variability in the shallow surface.

  11. Exploiting level anti-crossings for efficient and selective transfer of hyperpolarization in coupled nuclear spin systems

    NARCIS (Netherlands)

    Pravdivtsev, A.N.; Yurkovskaya, A.V.; Kaptein, R.; Miesel, K.; Vieth, H.-M.; Ivanov, K.L.

    2013-01-01

    Spin hyperpolarization can be coherently transferred to other nuclei in field-cycling NMR experiments. At low magnetic fields spin polarization is redistributed in a strongly coupled network of spins. Polarization transfer is most efficient at fields where level anti-crossings (LACs) occur for the

  12. Optimization of Xenon Biosensors for Detection of Protein Interactions

    International Nuclear Information System (INIS)

    Lowery, Thomas J.; Garcia, Sandra; Chavez, Lana; Ruiz, E.Janette; Wu, Tom; Brotin, Thierry; Dutasta, Jean-Pierre; King, David S.; Schultz, Peter G.; Pines, Alex; Wemmer, David E.

    2005-08-01

    Hyperpolarized 129Xe NMR can detect the presence of specific low-concentration biomolecular analytes by means of the xenon biosensor, which consists of a water-soluble, targeted cryptophane-A cage that encapsulates xenon. In this work we use the prototypical biotinylated xenon biosensor to determine the relationship between the molecular composition of the xenon biosensor and the characteristics of protein-bound resonances. The effects of diastereomer overlap, dipole-dipole coupling, chemical shift anisotropy, xenon exchange, and biosensor conformational exchange on protein-bound biosensor signal were assessed. It was found that optimal protein-bound biosensor signal can be obtained by minimizing the number of biosensor diastereomers and using a flexible linker of appropriate length. Both the linewidth and sensitivity of chemical shift to protein binding of the xenon biosensor were found to be inversely proportional to linker length

  13. Determination of xenon in irradiated nuclear fuel using a shielded electron microprobe

    International Nuclear Information System (INIS)

    Jenson, E.D.

    1983-06-01

    The technique described produces a semi-quantitative determination of the distribution of xenon present in a section of fuel pin along a predetermined line. The x-ray counting technique chosen is to drive the spectrometer over the peak in small increments, counting at each step, then to integrate the resulting data over the entire peak. Counting times are usually 10 sec at each step and there are 30 to 40 steps over a peak. Interferences and possible loss of Xe due to local heating are discussed. Comparison with independent analysis is presented

  14. Investigation into coadsorption of krypton, xenon and water vapor from nuclear power plant gaseous wastes

    International Nuclear Information System (INIS)

    Nakhutin, I.E.; Ochkin, D.V.; Tret'yak, S.A.

    1980-01-01

    Coadsorption of steam, crypton and xenon out of air by CKT-6A activated carbon under equilibrium conditions at different temperature and out of nitrogen flow by the zeolites of NaA, NaX, CaA, CaX, NaM type, ''Molecular sieves 4A'' polish zeolite, KCM silica gel, A-1 alumina gel, CKT-3 activated carbon under dynamic conditions at room temperature was investigated. A considerable moisture effect during the noble gases adsorption by the activated carbon has been revealed. A relative gas humidity in a radiochromatography system where the activated carbon is used must not exceed a value at which polymolecular adsorption begins. The NaA domestic zeolite and ''Molecular sieves 4A'' polish zeolite can be recommended for drying gas in NPP gas cleaning systems. These zeolites have considerable moisture capacity and good dynamic properties: their moisture capacity has a relatively weak dependence on temperature; adsorbents practically do not adsorb crypton and xenon, which is of great importance when equipping the devices with the biological protection. A linear dependence of noble gas passage time through a layer can be practically used to determine an adsorbent poisoning degree [ru

  15. Hyperpolarized NMR Probes for Biological Assays

    Directory of Open Access Journals (Sweden)

    Sebastian Meier

    2014-01-01

    Full Text Available During the last decade, the development of nuclear spin polarization enhanced (hyperpolarized molecular probes has opened up new opportunities for studying the inner workings of living cells in real time. The hyperpolarized probes are produced ex situ, introduced into biological systems and detected with high sensitivity and contrast against background signals using high resolution NMR spectroscopy. A variety of natural, derivatized and designed hyperpolarized probes has emerged for diverse biological studies including assays of intracellular reaction progression, pathway kinetics, probe uptake and export, pH, redox state, reactive oxygen species, ion concentrations, drug efficacy or oncogenic signaling. These probes are readily used directly under natural conditions in biofluids and are often directly developed and optimized for cellular assays, thus leaving little doubt about their specificity and utility under biologically relevant conditions. Hyperpolarized molecular probes for biological NMR spectroscopy enable the unbiased detection of complex processes by virtue of the high spectral resolution, structural specificity and quantifiability of NMR signals. Here, we provide a survey of strategies used for the selection, design and use of hyperpolarized NMR probes in biological assays, and describe current limitations and developments.

  16. Optical pumping and xenon NMR

    International Nuclear Information System (INIS)

    Raftery, M.D.

    1991-11-01

    Nuclear Magnetic Resonance (NMR) spectroscopy of xenon has become an important tool for investigating a wide variety of materials, especially those with high surface area. The sensitivity of its chemical shift to environment, and its chemical inertness and adsorption properties make xenon a particularly useful NMR probe. This work discusses the application of optical pumping to enhance the sensitivity of xenon NMR experiments, thereby allowing them to be used in the study of systems with lower surface area. A novel method of optically-pumping 129 Xe in low magnetic field below an NMR spectrometer and subsequent transfer of the gas to high magnetic field is described. NMR studies of the highly polarized gas adsorbed onto powdered samples with low to moderate surface areas are now possible. For instance, NMR studies of optically-pumped xenon adsorbed onto polyacrylic acid show that xenon has a large interaction with the surface. By modeling the low temperature data in terms of a sticking probability and the gas phase xenon-xenon interaction, the diffusion coefficient for xenon at the surface of the polymer is determined. The sensitivity enhancement afforded by optical pumping also allows the NMR observation of xenon thin films frozen onto the inner surfaces of different sample cells. The geometry of the thin films results in interesting line shapes that are due to the bulk magnetic susceptibility of xenon. Experiments are also described that combine optical pumping with optical detection for high sensitivity in low magnetic field to observe the quadrupoler evolution of 131 Xe spins at the surface of the pumping cells. In cells with macroscopic asymmetry, a residual quadrupolar interaction causes a splitting in the 131 Xe NMR frequencies in bare Pyrex glass cells and cells with added hydrogen

  17. Calculation of binary magnetic properties and potential energy curve in xenon dimer: second virial coefficient of (129)Xe nuclear shielding.

    Science.gov (United States)

    Hanni, Matti; Lantto, Perttu; Runeberg, Nino; Jokisaari, Jukka; Vaara, Juha

    2004-09-22

    Quantum chemical calculations of the nuclear shielding tensor, the nuclear quadrupole coupling tensor, and the spin-rotation tensor are reported for the Xe dimer using ab initio quantum chemical methods. The binary chemical shift delta, the anisotropy of the shielding tensor Delta sigma, the nuclear quadrupole coupling tensor component along the internuclear axis chi( parallel ), and the spin-rotation constant C( perpendicular ) are presented as a function of internuclear distance. The basis set superposition error is approximately corrected for by using the counterpoise correction (CP) method. Electron correlation effects are systematically studied via the Hartree-Fock, complete active space self-consistent field, second-order Møller-Plesset many-body perturbation, and coupled-cluster singles and doubles (CCSD) theories, the last one without and with noniterative triples, at the nonrelativistic all-electron level. We also report a high-quality theoretical interatomic potential for the Xe dimer, gained using the relativistic effective potential/core polarization potential scheme. These calculations used valence basis set of cc-pVQZ quality supplemented with a set of midbond functions. The second virial coefficient of Xe nuclear shielding, which is probably the experimentally best-characterized intermolecular interaction effect in nuclear magnetic resonance spectroscopy, is computed as a function of temperature, and compared to experiment and earlier theoretical results. The best results for the second virial coefficient, obtained using the CCSD(CP) binary chemical shift curve and either our best theoretical potential or the empirical potentials from the literature, are in good agreement with experiment. Zero-point vibrational corrections of delta, Delta sigma, chi (parallel), and C (perpendicular) in the nu=0, J=0 rovibrational ground state of the xenon dimer are also reported.

  18. Separation of krypton and xenon from the offgas of nuclear facilities

    International Nuclear Information System (INIS)

    Ammon, R. von; Bumiller, W.; Burkhardt, H.G.; Franz, G.; Hutter, E.; Knittel, G.; Neffe, G.; Penzhorn, R.D.

    1978-01-01

    During the test runs of the KRETA plant with the three-component system N 2 -Kr-Xe the concentration range of Kr and Xe in the feed gas could be determined where desublimation in the vicinity of the feed entry into the column takes place. This range decreases with decreasing total gas flow and increasing column pressure. The Kr recycle stream which is being planned for the improved offgas specification system of the WAK (project AZUR) was simulated by increasing the Kr feed concentration. The tendency of xenon to freeze out also decreases by this means. Analysis and control of H 2 during the catalytic reduction of O 2 and NOsub(x) is achieved best using the method of measuring combustion heats. The cell of Leeds and Northrup operates at room temperature and is insensitive towards NOsub(x). CO 2 is partially reduced by H 2 on the Ru-catalyst, but only if there is no O 2 present. Acid resistant molecular sieves (e.g. Norton Zeolen) adsorb Krypton almost twice as well as the type 5A. The same is true with NO. However, NH 3 and NO 2 are adsorbed less strongly on Zeolen as on 5A. (orig.) [de

  19. Hyperpolarized Nanodiamond Surfaces.

    Science.gov (United States)

    Rej, Ewa; Gaebel, Torsten; Waddington, David E J; Reilly, David J

    2017-01-11

    The widespread use of nanodiamond as a biomedical platform for drug-delivery, imaging, and subcellular tracking applications stems from its nontoxicity and unique quantum mechanical properties. Here, we extend this functionality to the domain of magnetic resonance, by demonstrating that the intrinsic electron spins on the nanodiamond surface can be used to hyperpolarize adsorbed liquid compounds at low fields and room temperature. By combining relaxation measurements with hyperpolarization, spins on the surface of the nanodiamond can be distinguished from those in the bulk liquid. These results are likely of use in signaling the controlled release of pharmaceutical payloads.

  20. Vacuum ultraviolet light production by nuclear irradiation of liquid and gaseous xenon

    Science.gov (United States)

    Baldwin, G. C.

    1981-01-01

    Recent Los Alamos investigations suggest that a liquefied noble element may be the long-sought medium for a nuclear-excited laser or flashlamp. Research is needed to confirm this finding and to provide a basis for design and application studies. Quantitative and qualitative information are needed on the nature and behavior of the excited species, the effects of impurities and additives in the liquid phase under nuclear excitation, and the existence and magnitudes of nonlinear effects. Questions that need to be addressed and the most appropriate types of facilities for this task are identified.

  1. Xenon-Xenon collision events in CMS

    CERN Multimedia

    Mc Cauley, Thomas

    2017-01-01

    One of the first-ever xenon-xenon collision events recorded by CMS during the LHC’s one-day-only heavy-ion run with xenon nuclei. The large number of tracks emerging from the centre of the detector show the many simultaneous nucleon-nucleon interactions that take place when two xenon nuclei, each with 54 protons and 75 neutrons, collide inside CMS.

  2. Relativistic effects in the intermolecular interaction-induced nuclear magnetic resonance parameters of xenon dimer

    DEFF Research Database (Denmark)

    Hanni, Matti; Lantto, Perttu; Ilias, Miroslav

    2007-01-01

    Relativistic effects on the 129Xe nuclear magnetic resonance shielding and 131Xe nuclear quadrupole coupling (NQC) tensors are examined in the weakly bound Xe2 system at different levels of theory including the relativistic four-component Dirac-Hartree-Fock (DHF) method. The intermolecular...... interaction-induced binary chemical shift d, the anisotropy of the shielding tensor ?s, and the NQC constant along the internuclear axis ?ll are calculated as a function of the internuclear distance. DHF shielding calculations are carried out using gauge-including atomic orbitals. For comparison, the full...... is obtained for d and ?s in Xe2. For these properties, the currently most complete theoretical description is obtained by a piecewise approximation where the uncorrelated relativistic DHF results obtained close to the basis-set limit are corrected, on the one hand, for NR correlation effects and, on the other...

  3. Relativistic effects in the intermolecular interaction-induced nuclear magnetic resonance parameters of xenon dimer.

    Science.gov (United States)

    Hanni, Matti; Lantto, Perttu; Ilias, Miroslav; Jensen, Hans Jorgen Aagaard; Vaara, Juha

    2007-10-28

    Relativistic effects on the (129)Xe nuclear magnetic resonance shielding and (131)Xe nuclear quadrupole coupling (NQC) tensors are examined in the weakly bound Xe(2) system at different levels of theory including the relativistic four-component Dirac-Hartree-Fock (DHF) method. The intermolecular interaction-induced binary chemical shift delta, the anisotropy of the shielding tensor Deltasigma, and the NQC constant along the internuclear axis chi( parallel) are calculated as a function of the internuclear distance. DHF shielding calculations are carried out using gauge-including atomic orbitals. For comparison, the full leading-order one-electron Breit-Pauli perturbation theory (BPPT) is applied using a common gauge origin. Electron correlation effects are studied at the nonrelativistic (NR) coupled-cluster singles and doubles with perturbational triples [CCSD(T)] level of theory. The fully relativistic second-order Moller-Plesset many-body perturbation (DMP2) theory is used to examine the cross coupling between correlation and relativity on NQC. The same is investigated for delta and Deltasigma by BPPT with a density functional theory model. A semiquantitative agreement between the BPPT and DHF binary property curves is obtained for delta and Deltasigma in Xe(2). For these properties, the currently most complete theoretical description is obtained by a piecewise approximation where the uncorrelated relativistic DHF results obtained close to the basis-set limit are corrected, on the one hand, for NR correlation effects and, on the other hand, for the BPPT-based cross coupling of relativity and correlation. For chi( parallel), the fully relativistic DMP2 results obtain a correction for NR correlation effects beyond MP2. The computed temperature dependence of the second virial coefficient of the (129)Xe nuclear shielding is compared to experiment in Xe gas. Our best results, obtained with the piecewise approximation for the binary chemical shift combined with the

  4. Electric dipole moment searches using the isotope 129-xenon

    Energy Technology Data Exchange (ETDEWEB)

    Kuchler, Florian

    2014-11-13

    Two new complementary experiments searching for a permanent electric dipole moment (EDM) of 129-xenon are presented. Besides demonstration of a sensitivity improvement by employing established methods and a highly sensitive SQUID detection system the progress towards a novel measurement approach is discussed. The new method introduces time-varying electric fields and a liquid hyper-polarized xenon sample with a potential improvement in sensitivity of three orders of magnitude. The search for EDMs is motivated by their symmetry-breaking nature. A non-zero EDM provides a new source of CP violation to solve the mystery of the huge excess of matter over anti-matter in our Universe.

  5. Development of a method for xenon determination in the microstructure of high burn-up nuclear fuel[Dissertation 17527

    Energy Technology Data Exchange (ETDEWEB)

    Horvath, M. I

    2008-07-01

    In nuclear fuel, in approximately one quarter of the fissions, one of the two formed fission products is gaseous. These are mainly the noble gases xenon and krypton with isotopes of xenon contributing up to 90% of the product gases. These noble fission gases do not combine with other species, and have a low solubility in the normally used uranium oxide matrix. They can be dissolved in the fuel matrix or precipitate in nanometer-sized bubbles within the fuel grain, in micrometer-sized bubbles at the grain boundaries, and a fraction also precipitates in fuel pores, coming from fuel fabrication. A fraction of the gas can also be released into the plenum of the fuel rod. With increasing fission, and therefore burn-up, the ceramic fuel material experiences a transformation of its structure in the 'cooler' rim region of the fuel. A subdivision occurs of the original fuel grains of few microns size into thousands of small grains of sub-micron sizes. Additionally, larger pores are formed, which also leads into an increasing porosity in the fuel rim, called high burn-up structure. In this structure, only a small fraction of the fission gas remains in the matrix, the major quantity is said to accumulate in these pores. Because of this accumulation, the knowledge of the quantities of gas within these pores is of major interest in consideration to burn-up, fuel performance and especially for safety issues. In case of design based accidents, i.e. rapidly increasing temperature transients, the behavior of the fuel has to be estimated. Various analytical techniques have been used to determine the Xe concentration in nuclear fuel samples. The capabilities of EPMA (Electron Probe Micro-Analyser) and SIMS (Secondary Ion Mass Spectrometry) have been studied and provided some qualitative information, which has been used for determining Xe-matrix concentrations. First approaches combining these two techniques to estimate pore pressures have been recently reported. However

  6. Development of a method for xenon determination in the microstructure of high burn-up nuclear fuel

    International Nuclear Information System (INIS)

    Horvath, M. I.

    2008-01-01

    In nuclear fuel, in approximately one quarter of the fissions, one of the two formed fission products is gaseous. These are mainly the noble gases xenon and krypton with isotopes of xenon contributing up to 90% of the product gases. These noble fission gases do not combine with other species, and have a low solubility in the normally used uranium oxide matrix. They can be dissolved in the fuel matrix or precipitate in nanometer-sized bubbles within the fuel grain, in micrometer-sized bubbles at the grain boundaries, and a fraction also precipitates in fuel pores, coming from fuel fabrication. A fraction of the gas can also be released into the plenum of the fuel rod. With increasing fission, and therefore burn-up, the ceramic fuel material experiences a transformation of its structure in the 'cooler' rim region of the fuel. A subdivision occurs of the original fuel grains of few microns size into thousands of small grains of sub-micron sizes. Additionally, larger pores are formed, which also leads into an increasing porosity in the fuel rim, called high burn-up structure. In this structure, only a small fraction of the fission gas remains in the matrix, the major quantity is said to accumulate in these pores. Because of this accumulation, the knowledge of the quantities of gas within these pores is of major interest in consideration to burn-up, fuel performance and especially for safety issues. In case of design based accidents, i.e. rapidly increasing temperature transients, the behavior of the fuel has to be estimated. Various analytical techniques have been used to determine the Xe concentration in nuclear fuel samples. The capabilities of EPMA (Electron Probe Micro-Analyser) and SIMS (Secondary Ion Mass Spectrometry) have been studied and provided some qualitative information, which has been used for determining Xe-matrix concentrations. First approaches combining these two techniques to estimate pore pressures have been recently reported. However, relevant Xe

  7. The XENON project for dark matter direct detection at LNGS

    Science.gov (United States)

    Molinario, Andrea

    2017-12-01

    The XENON project at INFN Laboratori Nazionali del Gran Sasso, Italy, aims at dark matter direct detection with liquid xenon dual-phase time projection chambers. Latest results of XENON100 detector exclude various models of leptophilic dark matter. A search for low mass weakly interacting massive particles was also performed, lowering the energy threshold for detection to 0.7 keV for nuclear recoils. The multi-ton XENON1T detector is fully installed and operating. It is expected to reach a sensitivity a factor 100 better than XENON100 with a 2 ton·year exposure.

  8. A novel MR contrast agent for angiography and perfusion: Hyperpolarized water

    DEFF Research Database (Denmark)

    Lipsø, Hans Kasper Wigh

    , hyperpolarized by dissolution Dynamic Nuclear Polarization (d-DNP), can be applied as an MRI contrast agent for angiography and perfusion. The first part of the project focuses on development of a protocol for production of large samples of hyperpolarized protons in D2O. The samples are polarized and dissolved...

  9. Xenon recovery from molybdenum-99 production

    International Nuclear Information System (INIS)

    Jubin, R.T.; Paviet, P.D.; Bresee, J.C.

    2016-01-01

    The U.S. Department of Energy Office of Nuclear Energy (DOE-NE) sponsors research and development on the recycle of used commercial nuclear fuel as an option for future nuclear fuel cycles that offers increased use of uranium and thorium resources and a possible reduction in the overall cost of nuclear waste management. The two alternatives, direct disposal of used fuel and fuel recycle, are broadly referred to as open and closed fuel cycles. One requirement of a closed fuel cycle is the safe management of radioactive off-gases, which includes 14 C, radioiodine and the noble gases, including radio-xenon. The longest lived relevant radio-xenon isotope is 127 Xe; with a half-life of just 36.35 days it is feasible to trap and hold the radio-xenon to allow for decay to safe environmental levels. However, the very weak chemical bonds of noble gases, in this case xenon, make them difficult to trap, which led to an extensive DOE-NE study of noble gas adsorption on various molecular sieves as an alternative to costly cryogenics processes. Preliminary results indicate that xenon adsorption at near room temperature on molecular sieves, both synthetic and natural, may have both cost and efficiency advantages over cryogenic processes. These results appear to have direct application in helping achieve the United Nations Security Council goal of reducing xenon emissions from medical isotope producers

  10. Xenon recovery from molybdenum-99 production

    Energy Technology Data Exchange (ETDEWEB)

    Jubin, R.T. [Oak Ridge National Laboratory, 1 Bethel Valley Rd, Oak Ridge, TN, 37931 (United States); Paviet, P.D.; Bresee, J.C. [U.S. Department of Energy,1000 Independence Ave, S.W., Washington DC, 20585-1290 (United States)

    2016-07-01

    The U.S. Department of Energy Office of Nuclear Energy (DOE-NE) sponsors research and development on the recycle of used commercial nuclear fuel as an option for future nuclear fuel cycles that offers increased use of uranium and thorium resources and a possible reduction in the overall cost of nuclear waste management. The two alternatives, direct disposal of used fuel and fuel recycle, are broadly referred to as open and closed fuel cycles. One requirement of a closed fuel cycle is the safe management of radioactive off-gases, which includes {sup 14}C, radioiodine and the noble gases, including radio-xenon. The longest lived relevant radio-xenon isotope is {sup 127}Xe; with a half-life of just 36.35 days it is feasible to trap and hold the radio-xenon to allow for decay to safe environmental levels. However, the very weak chemical bonds of noble gases, in this case xenon, make them difficult to trap, which led to an extensive DOE-NE study of noble gas adsorption on various molecular sieves as an alternative to costly cryogenics processes. Preliminary results indicate that xenon adsorption at near room temperature on molecular sieves, both synthetic and natural, may have both cost and efficiency advantages over cryogenic processes. These results appear to have direct application in helping achieve the United Nations Security Council goal of reducing xenon emissions from medical isotope producers.

  11. Hyperpolarized 129Xe MRI: A viable functional lung imaging modality?

    International Nuclear Information System (INIS)

    Patz, Samuel; Hersman, F. William; Muradian, Iga; Hrovat, Mirko I.; Ruset, Iulian C.; Ketel, Stephen; Jacobson, Francine; Topulos, George P.; Hatabu, Hiroto; Butler, James P.

    2007-01-01

    The majority of researchers investigating hyperpolarized gas MRI as a candidate functional lung imaging modality have used 3 He as their imaging agent of choice rather than 129 Xe. This preference has been predominantly due to, 3 He providing stronger signals due to higher levels of polarization and higher gyromagnetic ratio, as well as its being easily available to more researchers due to availability of polarizers (USA) or ease of gas transport (Europe). Most researchers agree, however, that hyperpolarized 129 Xe will ultimately emerge as the imaging agent of choice due to its unlimited supply in nature and its falling cost. Our recent polarizer technology delivers vast improvements in hyperpolarized 129 Xe output. Using this polarizer, we have demonstrated the unique property of xenon to measure alveolar surface area noninvasively. In this article, we describe our human protocols and their safety, and our results for the measurement of the partial pressure of pulmonary oxygen (pO 2 ) by observation of 129 Xe signal decay. We note that the measurement of pO 2 by observation of 129 Xe signal decay is more complex than that for 3 He because of an additional signal loss mechanism due to interphase diffusion of 129 Xe from alveolar gas spaces to septal tissue. This results in measurements of an equivalent pO 2 that accounts for both traditional T 1 decay from pO 2 and that from interphase diffusion. We also provide an update on new technological advancements that form the foundation for an improved compact design polarizer as well as improvements that provide another order-of-magnitude scale-up in xenon polarizer output

  12. Hyperpolarized singlet NMR on a small animal imaging system

    DEFF Research Database (Denmark)

    Laustsen, Christoffer; Pileio, Giuseppe; Tayler, Michael C. D.

    2012-01-01

    Nuclear spin hyperpolarization makes a significant advance toward overcoming the sensitivity limitations of in vivo magnetic resonance imaging, particularly in the case of low-gamma nuclei. The sensitivity may be improved further by storing the hyperpolarization in slowly relaxing singlet...... populations of spin- 1/2 pairs. Here, we report hyperpolarized 13C spin order transferred into and retrieved from singlet spin order using a small animal magnetic resonance imaging scanner. For spins in sites with very similar chemical shifts, singlet spin order is sustained in high magnetic field without...... requiring strong radiofrequency irradiation. The demonstration of robust singlet-to-magnetization conversion, and vice versa, on a small animal scanner, is promising for future in vivo and clinical deployments....

  13. Cryogenics free production of hyperpolarized 129Xe and 83Kr for biomedical MRI applications

    Science.gov (United States)

    Hughes-Riley, Theodore; Six, Joseph S.; Lilburn, David M. L.; Stupic, Karl F.; Dorkes, Alan C.; Shaw, Dominick E.; Pavlovskaya, Galina E.; Meersmann, Thomas

    2013-12-01

    As an alternative to cryogenic gas handling, hyperpolarized (hp) gas mixtures were extracted directly from the spin exchange optical pumping (SEOP) process through expansion followed by compression to ambient pressure for biomedical MRI applications. The omission of cryogenic gas separation generally requires the usage of high xenon or krypton concentrations at low SEOP gas pressures to generate hp 129Xe or hp 83Kr with sufficient MR signal intensity for imaging applications. Two different extraction schemes for the hp gasses were explored with focus on the preservation of the nuclear spin polarization. It was found that an extraction scheme based on an inflatable, pressure controlled balloon is sufficient for hp 129Xe handling, while 83Kr can efficiently be extracted through a single cycle piston pump. The extraction methods were tested for ex vivo MRI applications with excised rat lungs. Precise mixing of the hp gases with oxygen, which may be of interest for potential in vivo applications, was accomplished during the extraction process using a piston pump. The 83Kr bulk gas phase T1 relaxation in the mixtures containing more than approximately 1% O2 was found to be slower than that of 129Xe in corresponding mixtures. The experimental setup also facilitated 129Xe T1 relaxation measurements as a function of O2 concentration within excised lungs.

  14. Cryogenics free production of hyperpolarized 129Xe and 83Kr for biomedical MRI applications☆

    Science.gov (United States)

    Hughes-Riley, Theodore; Six, Joseph S.; Lilburn, David M.L.; Stupic, Karl F.; Dorkes, Alan C.; Shaw, Dominick E.; Pavlovskaya, Galina E.; Meersmann, Thomas

    2013-01-01

    As an alternative to cryogenic gas handling, hyperpolarized (hp) gas mixtures were extracted directly from the spin exchange optical pumping (SEOP) process through expansion followed by compression to ambient pressure for biomedical MRI applications. The omission of cryogenic gas separation generally requires the usage of high xenon or krypton concentrations at low SEOP gas pressures to generate hp 129Xe or hp 83Kr with sufficient MR signal intensity for imaging applications. Two different extraction schemes for the hp gasses were explored with focus on the preservation of the nuclear spin polarization. It was found that an extraction scheme based on an inflatable, pressure controlled balloon is sufficient for hp 129Xe handling, while 83Kr can efficiently be extracted through a single cycle piston pump. The extraction methods were tested for ex vivo MRI applications with excised rat lungs. Precise mixing of the hp gases with oxygen, which may be of interest for potential in vivo applications, was accomplished during the extraction process using a piston pump. The 83Kr bulk gas phase T1 relaxation in the mixtures containing more than approximately 1% O2 was found to be slower than that of 129Xe in corresponding mixtures. The experimental setup also facilitated 129Xe T1 relaxation measurements as a function of O2 concentration within excised lungs. PMID:24135800

  15. Chromatographic separation of radioactive noble gases from xenon

    Science.gov (United States)

    Akerib, D. S.; Araújo, H. M.; Bai, X.; Bailey, A. J.; Balajthy, J.; Beltrame, P.; Bernard, E. P.; Bernstein, A.; Biesiadzinski, T. P.; Boulton, E. M.; Bramante, R.; Cahn, S. B.; Carmona-Benitez, M. C.; Chan, C.; Chiller, A. A.; Chiller, C.; Coffey, T.; Currie, A.; Cutter, J. E.; Davison, T. J. R.; Dobi, A.; Dobson, J. E. Y.; Druszkiewicz, E.; Edwards, B. N.; Faham, C. H.; Fiorucci, S.; Gaitskell, R. J.; Gehman, V. M.; Ghag, C.; Gibson, K. R.; Gilchriese, M. G. D.; Hall, C. R.; Hanhardt, M.; Haselschwardt, S. J.; Hertel, S. A.; Hogan, D. P.; Horn, M.; Huang, D. Q.; Ignarra, C. M.; Ihm, M.; Jacobsen, R. G.; Ji, W.; Kamdin, K.; Kazkaz, K.; Khaitan, D.; Knoche, R.; Larsen, N. A.; Lee, C.; Lenardo, B. G.; Lesko, K. T.; Lindote, A.; Lopes, M. I.; Manalaysay, A.; Mannino, R. L.; Marzioni, M. F.; McKinsey, D. N.; Mei, D.-M.; Mock, J.; Moongweluwan, M.; Morad, J. A.; Murphy, A. St. J.; Nehrkorn, C.; Nelson, H. N.; Neves, F.; O'Sullivan, K.; Oliver-Mallory, K. C.; Palladino, K. J.; Pease, E. K.; Pech, K.; Phelps, P.; Reichhart, L.; Rhyne, C.; Shaw, S.; Shutt, T. A.; Silva, C.; Solovov, V. N.; Sorensen, P.; Stephenson, S.; Sumner, T. J.; Szydagis, M.; Taylor, D. J.; Taylor, W.; Tennyson, B. P.; Terman, P. A.; Tiedt, D. R.; To, W. H.; Tripathi, M.; Tvrznikova, L.; Uvarov, S.; Verbus, J. R.; Webb, R. C.; White, J. T.; Whitis, T. J.; Witherell, M. S.; Wolfs, F. L. H.; Yazdani, K.; Young, S. K.; Zhang, C.

    2018-01-01

    The Large Underground Xenon (LUX) experiment operates at the Sanford Underground Research Facility to detect nuclear recoils from the hypothetical Weakly Interacting Massive Particles (WIMPs) on a liquid xenon target. Liquid xenon typically contains trace amounts of the noble radioactive isotopes 85Kr and 39Ar that are not removed by the in situ gas purification system. The decays of these isotopes at concentrations typical of research-grade xenon would be a dominant background for a WIMP search experiment. To remove these impurities from the liquid xenon, a chromatographic separation system based on adsorption on activated charcoal was built. 400 kg of xenon was processed, reducing the average concentration of krypton from 130 ppb to 3.5 ppt as measured by a cold-trap assisted mass spectroscopy system. A 50 kg batch spiked to 0.001 g/g of krypton was processed twice and reduced to an upper limit of 0.2 ppt.

  16. Observation and applications of single-electron charge signals in the XENON100 experiment

    NARCIS (Netherlands)

    Aprile, E.; et al., [Unknown; Alfonsi, M.; Colijn, A.P.; Decowski, M.P.

    2014-01-01

    The XENON100 dark matter experiment uses liquid xenon in a time projection chamber (TPC) to measure xenon nuclear recoils resulting from the scattering of dark matter weakly interacting massive particles (WIMPs). In this paper, we report the observation of single-electron charge signals which are

  17. Memory Effects Study of Measuring Radioactive Xenon Isotopes With β-γ Coincidence Method

    International Nuclear Information System (INIS)

    Jia Huaimao; Wang Shilian; Wang Jun; Li Qi; Zhao Yungang; Fan Yuanqing; Zhang Xinjun

    2010-01-01

    The β-γ coincidence technique is a kind of the key important method to detect radioactive xenon isotopes for the Comprehensive Nuclear-Test-Ban Treaty (CTBT). This paper describes noble gases memory effects of β-γ coincidence detector. Xenon memory effects were measured and its influence on detector's minimum detectable activity (MDA) was evaluated. The methods of reducing xenon memory effects were studied. In conclusion, aluminium coated plastic scintillator and YAP scintillator can remarkably decrease xenon memory effects. (authors)

  18. Improvement of spin-exchange optical pumping of xenon-129 using in situ NMR measurement in ultra-low magnetic field

    Science.gov (United States)

    Takeda, Shun; Kumagai, Hiroshi

    2018-02-01

    Hyperpolarized (HP) noble gas has attracted attention in NMR / MRI. In an ultra-low magnetic field, the effectiveness of signal enhancement by HP noble gas should be required because reduction of the signal intensity is serious. One method of generating HP noble gas is spin exchange optical pumping which uses selective excitation of electrons of alkali metal vapor and spin transfer to nuclear spin by collision to noble gas. Although SEOP does not require extreme cooling or strong magnetic field, generally it required large-scale equipment including high power light source to generate HP noble gas with high efficiency. In this study, we construct a simply generation system of HP xenon-129 by SEOP with an ultralow magnetic field (up to 1 mT) and small-scale light source (about 1W). In addition, we measure in situ NMR signal at the same time, and then examine efficient conditions for SEOP in ultra-low magnetic fields.

  19. Imaging Human Brain Perfusion with Inhaled Hyperpolarized 129Xe MR Imaging.

    Science.gov (United States)

    Rao, Madhwesha R; Stewart, Neil J; Griffiths, Paul D; Norquay, Graham; Wild, Jim M

    2018-02-01

    Purpose To evaluate the feasibility of directly imaging perfusion of human brain tissue by using magnetic resonance (MR) imaging with inhaled hyperpolarized xenon 129 ( 129 Xe). Materials and Methods In vivo imaging with 129 Xe was performed in three healthy participants. The combination of a high-yield spin-exchange optical pumping 129 Xe polarizer, custom-built radiofrequency coils, and an optimized gradient-echo MR imaging protocol was used to achieve signal sensitivity sufficient to directly image hyperpolarized 129 Xe dissolved in the human brain. Conventional T1-weighted proton (hydrogen 1 [ 1 H]) images and perfusion images by using arterial spin labeling were obtained for comparison. Results Images of 129 Xe uptake were obtained with a signal-to-noise ratio of 31 ± 9 and demonstrated structural similarities to the gray matter distribution on conventional T1-weighted 1 H images and to perfusion images from arterial spin labeling. Conclusion Hyperpolarized 129 Xe MR imaging is an injection-free means of imaging the perfusion of cerebral tissue. The proposed method images the uptake of inhaled xenon gas to the extravascular brain tissue compartment across the intact blood-brain barrier. This level of sensitivity is not readily available with contemporary MR imaging methods. © RSNA, 2017.

  20. Quantification of human lung structure and physiology using hyperpolarized 129Xe.

    Science.gov (United States)

    Chang, Yulin V; Quirk, James D; Ruset, Iulian C; Atkinson, Jeffrey J; Hersman, F William; Woods, Jason C

    2014-01-01

    To present in vivo, human validation of a previously proposed method to measure key pulmonary parameters related to lung microstructure and physiology. Some parameters, such as blood-air barrier thickness, cannot be measured readily by any other noninvasive modality. Healthy volunteers (n = 12) were studied in 1.5T and 3T whole body human scanners using hyperpolarized xenon. Xenon uptake by lung parenchyma and blood was measured using a chemical shift saturation recovery sequence. Both dissolved-xenon peaks at 197 ppm and 217-218 ppm were fitted against a model of xenon exchange (MOXE) as functions of exchange time. Parameters related to lung function and structure can be obtained by fitting to this model. The following results were obtained from xenon uptake (averaged over all healthy volunteers): surface-area-to-volume ratio = 210 ± 50 cm(-1) ; total septal wall thickness = 9.2 ± 6.5 μm; blood-air barrier thickness = 1.0 ± 0.3 μm; hematocrit = 27 ± 4%; pulmonary capillary blood transit time = 1.3 ± 0.3 s, in good agreement with literature values from invasive experiments. More detailed fitting results are listed in the text. The initial in vivo human results demonstrate that our proposed methods can be used to noninvasively determine lung physiology by simultaneous quantification of a few important pulmonary parameters. This method is highly promising to become a versatile screening method for lung diseases. Copyright © 2013 Wiley Periodicals, Inc.

  1. NMR and MRI of continuously dissolved hyperpolarized {sup 129}Xe by means of hollow fibers

    Energy Technology Data Exchange (ETDEWEB)

    Amor, Nadia; Kueppers, Markus; Bluemich, Bernhard [ITMC of RWTH Aachen University (Germany); Hamilton, Kathrin; Schmitz-Rode, Thomas; Steinseifer, Ulrich [HIA of RWTH Aachen University (Germany); Appelt, Stephan [Research Center Juelich (Germany)

    2011-07-01

    Various methods of hyperpolarizing (HP) spin systems have been developed during the last years to increase the intrinsically low sensitivity of NMR by several orders of magnitude. Among them is the hyperpolarization of {sup 129}Xe via Spin Exchange Optical Pumping (SEOP). NMR of HP {sup 129}Xe is of great interest because of its good solubility and its very sensitive chemical shift. The main obstacle for many applications is the efficient and continuous dissolution into carrier agents without formation of foams or bubbles. It has been overcome by the so-called ''xenonizer'' setups. They mainly consist of commercially available hollow fiber membranes typically used in clinical oxygenators. A purpose-built xenonizer setup has been developed and analyzed in detail by NMR spectroscopy and MRI for varying fiber materials as well as for different fluids, including bio-relevant fluids such as blood, plasma, and erythrocytes. As a result, the xenonizer technology could be further understood and improved, and new applications of HP {sup 129}Xe for medical NMR were explored.

  2. Liquid xenon detector engineering

    International Nuclear Information System (INIS)

    Chen, E.; Chen, M.; Gaudreau, M.P.J.; Montgomery, D.B.; Pelly, J.D.; Shotkin, S.; Sullivan, J.D.; Sumorok, K.; Yan, X.; Zhang, X.; Lebedenko, V.

    1991-01-01

    The design, engineering constraints and R and D status of a 15 m 3 precision liquid xenon, electromagnetic calorimeter for the Superconducting Super Collider are discussed in this paper. Several prototype liquid xenon detectors have been built, and preliminary results are described. The design of a conical 7 cell by 7 cell detector capable of measuring fully contained high energy electron showers is described in detail

  3. Dynamic coronary MR angiography in a pig model with hyperpolarized water

    DEFF Research Database (Denmark)

    Lipsø, Hans Kasper Wigh; Hansen, Esben Søvsø Szocska; Tougaard, Rasmus Stilling

    2018-01-01

    To investigate dynamic coronary MR angiography using hyperpolarized water as a positive contrast agent. Hyperpolarization can increase the signal by several orders of magnitude, and has recently been translated to human cardiac application. The aim was to achieve large 1 H signal enhancement...... to allow high-resolution imaging of the coronary arteries. Protons in D2 O were hyperpolarized by dissolution dynamic nuclear polarization. A total of 18 mL of hyperpolarized water was injected into the coronary arteries of healthy pigs (N = 9; 3 injections in 3 animals). The MRI images were acquired...... with a gradient-echo sequence in an oblique slab covering the main left coronary arteries with 0.55 mm in-plane resolution. The acquisition time was 870 ms per frame. A more than 200-fold signal enhancement compared with thermally polarized water at 3 T was obtained. Coronary angiographic images with a signal...

  4. Design of a 15N Molecular Unit to Achieve Long Retention of Hyperpolarized Spin State

    Science.gov (United States)

    Nonaka, Hiroshi; Hirano, Masashi; Imakura, Yuki; Takakusagi, Yoichi; Ichikawa, Kazuhiro; Sando, Shinsuke

    2017-01-01

    Nuclear hyperpolarization is a phenomenon that can be used to improve the sensitivity of magnetic resonance molecular sensors. However, such sensors typically suffer from short hyperpolarization lifetime. Herein we report that [15N, D14]trimethylphenylammonium (TMPA) has a remarkably long spin-lattice relaxation time (1128 s, 14.1 T, 30 °C, D2O) on its 15N nuclei and achieves a long retention of the hyperpolarized state. [15N, D14]TMPA-based hyperpolarized sensor for carboxylesterase allowed the highly sensitive analysis of enzymatic reaction by 15N NMR for over 40 min in phophate-buffered saline (H2O, pH 7.4, 37 °C).

  5. Separation and purification of xenon

    International Nuclear Information System (INIS)

    Schlea, C.S.

    1978-01-01

    Xenon is separated from a mixture of xenon and krypton by extractive distillation using carbon tetrafluoride as the partitioning agent. Krypton is flushed out of the distillation column with CF 4 in the gaseous overhead stream while purified xenon is recovered from the liquid bottoms. The distillation is conducted at about atmospheric pressure or at subatmospheric pressure

  6. Requirements for Xenon International

    Energy Technology Data Exchange (ETDEWEB)

    Hayes, James C.; Ely, James H.

    2013-09-26

    This document defines the requirements for the new Xenon International radioxenon system. The output of this project will be a Pacific Northwest National Laboratory (PNNL) developed prototype and a manufacturer-developed production prototype. The two prototypes are intended to be as close to matching as possible; this will be facilitated by overlapping development cycles and open communication between PNNL and the manufacturer.

  7. Requirements for Xenon International

    Energy Technology Data Exchange (ETDEWEB)

    Hayes, James C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Ely, James H. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Haas, Derek A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Harper, Warren W. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Heimbigner, Tom R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hubbard, Charles W. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Humble, Paul H. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Madison, Jill C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Morris, Scott J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Panisko, Mark E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Ripplinger, Mike D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Stewart, Timothy L. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-12-30

    This document defines the requirements for the new Xenon International radioxenon system. The output of this project will be a Pacific Northwest National Laboratory (PNNL) developed prototype and a manufacturer-developed production prototype. The two prototypes are intended to be as close to matching as possible; this will be facilitated by overlapping development cycles and open communication between PNNL and the manufacturer.

  8. Xenon-133 and caesium-137 releases into the atmosphere from the Fukushima Dai-ichi nuclear power plant: determination of the source term, atmospheric dispersion, and deposition

    Science.gov (United States)

    Stohl, A.; Seibert, P.; Wotawa, G.; Arnold, D.; Burkhart, J. F.; Eckhardt, S.; Tapia, C.; Vargas, A.; Yasunari, T. J.

    2012-04-01

    This presentation will show the results of a paper currently under review in ACPD and some additional new results, including more data and with an independent box modeling approach to support some of the findings of the ACPD paper. On 11 March 2011, an earthquake occurred about 130 km off the Pacific coast of Japan's main island Honshu, followed by a large tsunami. The resulting loss of electric power at the Fukushima Dai-ichi nuclear power plant (FD-NPP) developed into a disaster causing massive release of radioactivity into the atmosphere. In this study, we determine the emissions of two isotopes, the noble gas xenon-133 (133Xe) and the aerosol-bound caesium-137 (137Cs), which have very different release characteristics as well as behavior in the atmosphere. To determine radionuclide emissions as a function of height and time until 20 April, we made a first guess of release rates based on fuel inventories and documented accident events at the site. This first guess was subsequently improved by inverse modeling, which combined the first guess with the results of an atmospheric transport model, FLEXPART, and measurement data from several dozen stations in Japan, North America and other regions. We used both atmospheric activity concentration measurements as well as, for 137Cs, measurements of bulk deposition. Regarding 133Xe, we find a total release of 16.7 (uncertainty range 13.4-20.0) EBq, which is the largest radioactive noble gas release in history not associated with nuclear bomb testing. There is strong evidence that the first strong 133Xe release started early, before active venting was performed. The entire noble gas inventory of reactor units 1-3 was set free into the atmosphere between 11 and 15 March 2011. For 137Cs, the inversion results give a total emission of 35.8 (23.3-50.1) PBq, or about 42% of the estimated Chernobyl emission. Our results indicate that 137Cs emissions peaked on 14-15 March but were generally high from 12 until 19 March, when they

  9. Gross xenon stability

    International Nuclear Information System (INIS)

    Lewins, J.D.; Wilson, P.P.H.

    1997-01-01

    The effect of xenon in thermal reactors on steady operation is generally destabilizing. Illustrating this involves the study of appropriate transfer functions, which may be conveniently displayed in three ways: as Bode, Nyquist, and root-locus diagrams. The three forms allow different aspects to be highlighted. These are illustrated for the effect of xenon with allowance not only for the stabilizing effect of the direct yield in fission but also to show the consequences of neglecting the time dependence due to the thermal capacity of the reactor. With careful interpretation, all these forms give an interpretation of stability that is consistent with direct evaluation and promote the understanding of the onset of gross oscillations in power

  10. The unbearable lightness of being: CDMS versus XENON

    CERN Document Server

    Frandsen, Mads T; McCabe, Christopher; Sarkar, Subir; Schmidt-Hoberg, Kai

    2013-01-01

    The CDMS-II collaboration has reported 3 events in a Si detector, which are consistent with being nuclear recoils due to scattering of Galactic dark matter particles with a mass of about 8.6 GeV and a cross-section on neutrons of about 2 x 10^-41 cm^2. While a previous result from the XENON10 experiment has supposedly ruled out such particles as dark matter, we find by reanalysing the XENON10 data that this is not the case. Some tension remains however with the upper limit placed by the XENON100 experiment, independently of astrophysical uncertainties concerning the Galactic dark matter distribution. We explore possible ways of ameliorating this tension by altering the properties of dark matter interactions. Nevertheless, even with standard couplings, light dark matter is consistent with both CDMS and XENON10/100.

  11. Autoionization in xenon

    International Nuclear Information System (INIS)

    Knight, R.D.; Wang, L.G.

    1986-01-01

    The authors have studied both even- and odd-parity autoionizing levels in xenon. These levels lie between the Xe/sup +/ /sup 2/P/sub 3/2/ and /sup 2/P/sub 1/2/ ionization limits. Their technique is laser spectroscopy of a thermal metastable atomic beam of xenon. One-photon laser spectroscopy from the 6s'[1/2]/sub 0/ level has been used to study the np'[1/2]/sub 1/ and np'[3/2]/sub 1/ autoionization doublets, n = 7-20. These had previously been observed only for n = 7,8. The authors are using a MQDT analysis of both discrete and autoionizing even-parity J = 1 levels (five channels) to understand the autoionization line profiles. They have also used two-photon laser spectroscopy from the 6s[3/2]/sub 2/ metastable level via various J = 1,2 6p' levels to observe the odd-parity ns'[1/2]/sub 0 1/, nd'[3/2]/sub 1 2/, and nd'[5/2]/sub 2 3/ autoionizing levels to n > 50. This is the first observation of J not equal to 1 odd-parity autoionization in xenon. The most striking feature of these spectra is the complete absence of the very intense, very broad transitions to nd'[3/2]/sub 1/, which dominate the photoabsorption spectrum from the xenon J = 0 ground state. The other nd' levels (J = 2.3) and ns'[1/2]/sub 0/ are all comparable in width to the previously observed ns'[1/2]/sub 1/ levels. The authors present the results of position and width measurements for these levels

  12. Dynamically Decoupled 13C Spins in Hyperpolarized Nanodiamond

    Science.gov (United States)

    Rej, Ewa; Gaebel, Torsten; Boele, Thomas; Waddington, David; Reilly, David

    The spin-spin relaxation time, T2, which determines how long a quantum state remains coherent, is an important factor for many applications ranging from MRI to quantum computing. A common technique used in quantum information technology to extend the T2, involves averaging out certain noise spectra via dynamical decoupling sequences. Depending on the nature of the noise in the system, specific sequences, such as CPMG, UDD or KDD, can be tailored to optimize T2. Here we combine hyperpolarization techniques and dynamical decoupling sequences to extend the T2 of 13C nuclear spins in nanodiamond by three orders of magnitude.

  13. ATLAS Event Display: First Xenon-Xenon Run 2017

    CERN Multimedia

    ATLAS Collaboration

    2017-01-01

    Event display from the xenon-xenon collision run of 12-13 October 2017. Curved cyan lines show the trajectories of charged particles in the tracking systems. The bottom right plot shows the distribution of energy deposited in the calorimeters, demonstrating the high particle multiplicity of the event. Two muon candidates are reconstructed at high pseudorapidity, as seen in the bottom left plot

  14. Studies to enhance the hyperpolarization level in PHIP-SAH-produced C13-pyruvate

    Science.gov (United States)

    Cavallari, Eleonora; Carrera, Carla; Aime, Silvio; Reineri, Francesca

    2018-04-01

    The use of [1-13C]pyruvate, hyperpolarized by dissolution-Dynamic Nuclear Polarization (d-DNP), in in vivo metabolic studies has developed quickly, thanks to the imaging probe's diagnostic relevance. Nevertheless, the cost of a d-DNP polarizer is quite high and the speed of hyperpolarization process is relatively slow, meaning that its use is limited to few research laboratories. ParaHydrogen Induced Polarization Side Arm Hydrogenation (PHIP-SAH) (Reineri et al., 2015) is a cost effective and easy-to-handle method that produces 13C-MR hyperpolarization in [1-13C]pyruvate and other metabolites. This work aims to identify the main determinants of the hyperpolarization levels observed in C13-pyruvate using this method. By dissecting the various steps of the PHIP-SAH procedure, it has been possible to assess the role of several experimental parameters whose optimization must be pursued if this method is to be made suitable for future translational steps. The search for possible solutions has led to improvements in the polarization of sodium [1-13C]pyruvate from 2% to 5%. Moreover, these results suggest that observed polarization levels could be increased considerably by an automatized procedure which would reduce the time required for the work-up passages that are currently carried out manually. The results reported herein mean that the attainment of polarization levels suitable for the metabolic imaging applications of these hyperpolarized substrates show significant promise.

  15. Hyperpolarized Porous Silicon Nanoparticles: Potential Theragnostic Material for ²⁹Si Magnetic Resonance Imaging.

    Science.gov (United States)

    Seo, Hyeonglim; Choi, Ikjang; Whiting, Nicholas; Hu, Jingzhe; Luu, Quy Son; Pudakalakatti, Shivanand; McCowan, Caitlin; Kim, Yaewon; Zacharias, Niki; Lee, Seunghyun; Bhattacharya, Pratip; Lee, Youngbok

    2018-05-20

    Porous silicon nanoparticles have recently garnered attention as potentially-promising biomedical platforms for drug delivery and medical diagnostics. Here, we demonstrate porous silicon nanoparticles as contrast agents for ²⁹Si magnetic resonance imaging. Size-controlled porous silicon nanoparticles were synthesized by magnesiothermic reduction of silica nanoparticles and were surface activated for further functionalization. Particles were hyperpolarized via dynamic nuclear polarization to enhance their ²⁹Si MR signals; the particles demonstrated long ²⁹Si spin-lattice relaxation (T₁) times (~ 25 mins), which suggests potential applicability for medical imaging. Furthermore, ²⁹Si hyperpolarization levels were sufficient to allow ²⁹Si MRI in phantoms. These results underscore the potential of porous silicon nanoparticles that, when combined with hyperpolarized magnetic resonance imaging, can be a powerful theragnostic deep tissue imaging platform to interrogate various biomolecular processes in vivo. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. XENON-133 IN CALIFORNIA, NEVADA, AND UTAH FROM THE CHERNOBYL ACCIDENT (JOURNAL VERSION)

    Science.gov (United States)

    The accident at the Chernobyl nuclear reactor in the USSR introduced numerous radioactive nuclides into the atmosphere, including the noble gas xenon-133. EPA's Environmental Monitoring Systems Laboratory, Las Vegas, NV, detected xenon-133 from the Chernobyl accident in air sampl...

  17. Exposure mode study to xenon-133 in a reactor building

    International Nuclear Information System (INIS)

    Perier, Aurelien

    2014-01-01

    The work described in this thesis focuses on the external and internal dose assessment to xenon-133. During the nuclear reactor operation, fission products and radioactive inert gases, as 133 Xe, are generated and might be responsible for the exposure of workers in case of clad defect. Particle Monte Carlo transport code is adapted in radioprotection to quantify dosimetric quantities. The study of exposure to xenon-133 is conducted by using Monte-Carlo simulations based on GEANT4, an anthropomorphic phantom, a realistic geometry of the reactor building, and compartmental models. The external exposure inside a reactor building is conducted with a realistic and conservative exposure scenario. The effective dose rate and the eye lens equivalent dose rate are determined by Monte-Carlo simulations. Due to the particular emission spectrum of xenon-133, the equivalent dose rate to the lens of eyes is discussed in the light of expected new eye dose limits. The internal exposure occurs while xenon-133 is inhaled. The lungs are firstly exposed by inhalation, and their equivalent dose rate is obtained by Monte-Carlo simulations. A biokinetic model is used to evaluate the internal exposure to xenon-133. This thesis gives us a better understanding to the dosimetric quantities related to external and internal exposure to xenon-133. Moreover the impacts of the dosimetric changes are studied on the current and future dosimetric limits. The dosimetric quantities are lower than the current and future dosimetric limits. (author)

  18. Xenon-133 and caesium-137 releases into the atmosphere from the Fukushima Dai-ichi nuclear power plant. Determination of the source term, atmospheric dispersion, and deposition

    International Nuclear Information System (INIS)

    Stohl, A.; Burkhart, J.F.; Eckhardt, S.; Seibert, P.; Arnold, D.; Technical Univ. of Catalonia, Barcelona; Tapia, C.; Vargas, A.; Yasunari, T.J.

    2012-01-01

    On 11 March 2011, an earthquake occurred about 130 km off the Pacific coast of Japan's main island Honshu, followed by a large tsunami. The resulting loss of electric power at the Fukushima Dai-ichi nuclear power plant developed into a disaster causing massive release of radioactivity into the atmosphere. In this study, we determine the emissions into the atmosphere of two isotopes, the noble gas xenon-133 ("1"3"3Xe) and the aerosol-bound caesium-137 ("1"3"7Cs), which have very different release characteristics as well as behavior in the atmosphere. To determine radionuclide emissions as a function of height and time until 20 April, we made a first guess of release rates based on fuel inventories and documented accident events at the site. This first guess was subsequently improved by inverse modeling, which combined it with the results of an atmospheric transport model, FLEXPART, and measurement data from several dozen stations in Japan, North America and other regions. We used both atmospheric activity concentration measurements as well as, for "1"3"7Cs, measurements of bulk deposition. Regarding "1"3"3Xe, we find a total release of 15.3 (uncertainty range 12.2-18.3) EBq, which is more than twice as high as the total release from Chernobyl and likely the largest radioactive noble gas release in history. The entire noble gas inventory of reactor units 1-3 was set free into the atmosphere between 11 and 15 March 2011. In fact, our release estimate is higher than the entire estimated "1"3"3Xe inventory of the Fukushima Dai-ichi nuclear power plant, which we explain with the decay of iodine-133 (half-life of 20.8 h) into "1"3"3Xe. There is strong evidence that the "1"3"3Xe release started before the first active venting was made, possibly indicating structural damage to reactor components and/or leaks due to overpressure which would have allowed early release of noble gases. For "1"3"7Cs, the inversion results give a total emission of 36.6 (20.1-53.1) PBq, or about

  19. Xenon-133 and caesium-137 releases into the atmosphere from the Fukushima Dai-ichi nuclear power plant: determination of the source term, atmospheric dispersion, and deposition

    Directory of Open Access Journals (Sweden)

    A. Stohl

    2012-03-01

    Full Text Available On 11 March 2011, an earthquake occurred about 130 km off the Pacific coast of Japan's main island Honshu, followed by a large tsunami. The resulting loss of electric power at the Fukushima Dai-ichi nuclear power plant developed into a disaster causing massive release of radioactivity into the atmosphere. In this study, we determine the emissions into the atmosphere of two isotopes, the noble gas xenon-133 (133Xe and the aerosol-bound caesium-137 (137Cs, which have very different release characteristics as well as behavior in the atmosphere. To determine radionuclide emissions as a function of height and time until 20 April, we made a first guess of release rates based on fuel inventories and documented accident events at the site. This first guess was subsequently improved by inverse modeling, which combined it with the results of an atmospheric transport model, FLEXPART, and measurement data from several dozen stations in Japan, North America and other regions. We used both atmospheric activity concentration measurements as well as, for 137Cs, measurements of bulk deposition. Regarding 133Xe, we find a total release of 15.3 (uncertainty range 12.2–18.3 EBq, which is more than twice as high as the total release from Chernobyl and likely the largest radioactive noble gas release in history. The entire noble gas inventory of reactor units 1–3 was set free into the atmosphere between 11 and 15 March 2011. In fact, our release estimate is higher than the entire estimated 133Xe inventory of the Fukushima Dai-ichi nuclear power plant, which we explain with the decay of iodine-133 (half-life of 20.8 h into 133Xe. There is strong evidence that the 133Xe release started before the first active venting was made, possibly indicating structural damage to reactor components and/or leaks due to overpressure which would have allowed early release of noble gases. For 137

  20. Xenon-133 and caesium-137 releases into the atmosphere from the Fukushima Dai-ichi nuclear power plant. Determination of the source term, atmospheric dispersion, and deposition

    Energy Technology Data Exchange (ETDEWEB)

    Stohl, A.; Burkhart, J.F.; Eckhardt, S. [NILU - Norwegian Institute for Air Research, Kjeller (Norway); Seibert, P. [Univ. of Natural Resources and Life Sciences, Vienna (Austria). Inst. of Meteorology; Wotawa, G. [Central Institute for Meteorology and Geodynamics, Vienna (Austria); Arnold, D. [Univ. of Natural Resources and Life Sciences, Vienna (Austria). Inst. of Meteorology; Technical Univ. of Catalonia, Barcelona (Spain). Inst. of Energy Technologies; Tapia, C. [Technical Univ. of Catalonia, Barcelona (Spain). Dept. of Physics and Nucelar Engineering; Vargas, A. [Technical Univ. of Catalonia, Barcelona (Spain). Inst. of Energy Technologies; Yasunari, T.J. [Univs. Space Research Association, Columbia, MD (United States). Goddard Earth Sciences and Technology and Research

    2012-07-01

    On 11 March 2011, an earthquake occurred about 130 km off the Pacific coast of Japan's main island Honshu, followed by a large tsunami. The resulting loss of electric power at the Fukushima Dai-ichi nuclear power plant developed into a disaster causing massive release of radioactivity into the atmosphere. In this study, we determine the emissions into the atmosphere of two isotopes, the noble gas xenon-133 ({sup 133}Xe) and the aerosol-bound caesium-137 ({sup 137}Cs), which have very different release characteristics as well as behavior in the atmosphere. To determine radionuclide emissions as a function of height and time until 20 April, we made a first guess of release rates based on fuel inventories and documented accident events at the site. This first guess was subsequently improved by inverse modeling, which combined it with the results of an atmospheric transport model, FLEXPART, and measurement data from several dozen stations in Japan, North America and other regions. We used both atmospheric activity concentration measurements as well as, for {sup 137}Cs, measurements of bulk deposition. Regarding {sup 133}Xe, we find a total release of 15.3 (uncertainty range 12.2-18.3) EBq, which is more than twice as high as the total release from Chernobyl and likely the largest radioactive noble gas release in history. The entire noble gas inventory of reactor units 1-3 was set free into the atmosphere between 11 and 15 March 2011. In fact, our release estimate is higher than the entire estimated {sup 133}Xe inventory of the Fukushima Dai-ichi nuclear power plant, which we explain with the decay of iodine-133 (half-life of 20.8 h) into {sup 133}Xe. There is strong evidence that the {sup 133}Xe release started before the first active venting was made, possibly indicating structural damage to reactor components and/or leaks due to overpressure which would have allowed early release of noble gases. For {sup 137}Cs, the inversion results give a total emission of 36

  1. Analysis of Cancer Metabolism by Imaging Hyperpolarized Nuclei: Prospects for Translation to Clinical Research

    Directory of Open Access Journals (Sweden)

    John Kurhanewicz

    2011-02-01

    Full Text Available A major challenge in cancer biology is to monitor and understand cancer metabolism in vivo with the goal of improved diagnosis and perhaps therapy. Because of the complexity of biochemical pathways, tracer methods are required for detecting specific enzyme-catalyzed reactions. Stable isotopes such as 13C or 15N with detection by nuclear magnetic resonance provide the necessary information about tissue biochemistry, but the crucial metabolites are present in low concentration and therefore are beyond the detection threshold of traditional magnetic resonance methods. A solution is to improve sensitivity by a factor of 10,000 or more by temporarily redistributing the populations of nuclear spins in a magnetic field, a process termed hyperpolarization. Although this effect is short-lived, hyperpolarized molecules can be generated in an aqueous solution and infused in vivo where metabolism generates products that can be imaged. This discovery lifts the primary constraint on magnetic resonance imaging for monitoring metabolism—poor sensitivity—while preserving the advantage of biochemical information. The purpose of this report was to briefly summarize the known abnormalities in cancer metabolism, the value and limitations of current imaging methods for metabolism, and the principles of hyperpolarization. Recent preclinical applications are described. Hyperpolarization technology is still in its infancy, and current polarizer equipment and methods are suboptimal. Nevertheless, there are no fundamental barriers to rapid translation of this exciting technology to clinical research and perhaps clinical care.

  2. Probing the porosity of cocrystallized MCM-49/ZSM-35 zeolites by hyperpolarized 129Xe NMR.

    Science.gov (United States)

    Liu, Yong; Zhang, Weiping; Xie, Sujuan; Xu, Longya; Han, Xiuwen; Bao, Xinhe

    2008-01-31

    One- and two-dimensional 129Xe NMR spectroscopy has been employed to study the porosity of cocrystallized MCM-49/ZSM-35 zeolites under the continuous flow of hyperpolarized xenon gas. It is found by variable-temperature experiments that Xe atoms can be adsorbed in different domains of MCM-49/ZSM-35 cocrystallized zeolites and the mechanically mixed counterparts. The exchange of Xe atoms in different types of pores is very fast at ambient temperatures. Even at very low temperature two-dimensional exchange spectra (EXSY) show that Xe atoms still undergo much faster exchange between MCM-49 and ZSM-35 analogues in the cocrystallized zeolites than in the mechanical mixture. This demonstrates that the MCM-49 and ZSM-35 analogues in cocrystallized zeolites may be stacked much closer than in the physical mixture, and some parts of intergrowth may be formed due to the partially similar basic structure of MCM-49 and ZSM-35.

  3. Signal yields, energy resolution, and recombination fluctuations in liquid xenon

    Science.gov (United States)

    Akerib, D. S.; Alsum, S.; Araújo, H. M.; Bai, X.; Bailey, A. J.; Balajthy, J.; Beltrame, P.; Bernard, E. P.; Bernstein, A.; Biesiadzinski, T. P.; Boulton, E. M.; Bramante, R.; Brás, P.; Byram, D.; Cahn, S. B.; Carmona-Benitez, M. C.; Chan, C.; Chiller, A. A.; Chiller, C.; Currie, A.; Cutter, J. E.; Davison, T. J. R.; Dobi, A.; Dobson, J. E. Y.; Druszkiewicz, E.; Edwards, B. N.; Faham, C. H.; Fiorucci, S.; Gaitskell, R. J.; Gehman, V. M.; Ghag, C.; Gibson, K. R.; Gilchriese, M. G. D.; Hall, C. R.; Hanhardt, M.; Haselschwardt, S. J.; Hertel, S. A.; Hogan, D. P.; Horn, M.; Huang, D. Q.; Ignarra, C. M.; Ihm, M.; Jacobsen, R. G.; Ji, W.; Kamdin, K.; Kazkaz, K.; Khaitan, D.; Knoche, R.; Larsen, N. A.; Lee, C.; Lenardo, B. G.; Lesko, K. T.; Lindote, A.; Lopes, M. I.; Manalaysay, A.; Mannino, R. L.; Marzioni, M. F.; McKinsey, D. N.; Mei, D.-M.; Mock, J.; Moongweluwan, M.; Morad, J. A.; Murphy, A. St. J.; Nehrkorn, C.; Nelson, H. N.; Neves, F.; O'Sullivan, K.; Oliver-Mallory, K. C.; Palladino, K. J.; Pease, E. K.; Phelps, P.; Reichhart, L.; Rhyne, C.; Shaw, S.; Shutt, T. A.; Silva, C.; Solmaz, M.; Solovov, V. N.; Sorensen, P.; Stephenson, S.; Sumner, T. J.; Szydagis, M.; Taylor, D. J.; Taylor, W. C.; Tennyson, B. P.; Terman, P. A.; Tiedt, D. R.; To, W. H.; Tripathi, M.; Tvrznikova, L.; Uvarov, S.; Verbus, J. R.; Webb, R. C.; White, J. T.; Whitis, T. J.; Witherell, M. S.; Wolfs, F. L. H.; Xu, J.; Yazdani, K.; Young, S. K.; Zhang, C.; LUX Collaboration

    2017-01-01

    This work presents an analysis of monoenergetic electronic recoil peaks in the dark-matter-search and calibration data from the first underground science run of the Large Underground Xenon (LUX) detector. Liquid xenon charge and light yields for electronic recoil energies between 5.2 and 661.7 keV are measured, as well as the energy resolution for the LUX detector at those same energies. Additionally, there is an interpretation of existing measurements and descriptions of electron-ion recombination fluctuations in liquid xenon as limiting cases of a more general liquid xenon recombination fluctuation model. Measurements of the standard deviation of these fluctuations at monoenergetic electronic recoil peaks exhibit a linear dependence on the number of ions for energy deposits up to 661.7 keV, consistent with previous LUX measurements between 2 and 16 keV with 3H. We highlight similarities in liquid xenon recombination for electronic and nuclear recoils with a comparison of recombination fluctuations measured with low-energy calibration data.

  4. Conception and synthesis of the new cryptophane for the applications in xenon NMR molecular imaging

    International Nuclear Information System (INIS)

    Gao, Bo

    2016-01-01

    Among all the imaging techniques, magnetic resonance imaging (MRI) offers several advantages owing to its low invasiveness, its harmlessness and its spatial in-depth resolution but suffers from poor sensitivity. To address this issue, different strategies were proposed, including the utilization of hyper-polarizable species such as "1"2"9Xe. Xenon is an inert gas with a polarizable electronic cloud which leads to an extreme sensitivity to its chemical environment. Its capacity of being hyper-polarized makes it possible to obtain a significant gain of sensitivity. Nevertheless, xenon has no specificity to any biological target therefore it needs to be encapsulated and vectorized. Different molecular cages were proposed and we are particularly interested in cryptophane which is one of the best candidates for xenon encapsulation. In this context, the objective of this thesis is to design new cryptophanes which can be used as molecular platforms to construct novel "1"2"9Xe MRI biosensors usable for in vivo imaging. To meet this demand, these cryptophanes should be mono-functionalizable and enough soluble in water. In this thesis, the polyethylene glycol (PEG) group is used to improve the poor solubility of the hydrophobic molecular cage. And there is a systematic discussion of how to break the symmetry of cryptophanes and different strategies were attempted to synthesize mono-functionalized cryptophanes. As a result, several PEGylated mono-functionalized cryptophanes were obtained and their properties for encapsulating xenon were tested [fr

  5. Nuclear structure studies in the xenon and radon region and the discovery of a new radon isotope by Penning-trap mass spectrometry

    CERN Document Server

    Neidherr, Dennis

    2010-01-01

    Nowadays high-precision mass measurements based on Penning traps allow a deep insight into the fundamental properties of nucleonic matter. To this end, the cyclotron frequency of an ion confined in a strong, homogeneous magnetic field B is determined. At the ISOLTRAP mass spectrometer at ISOLDE / CERN the masses of short-lived radioactive nuclei with half-lives down to several ten ms can be measured with an uncertainty in the order of 10$^{-8}$and below. ISOLTRAP consists of an RFQ cooler and buncher to cool and accumulate the ions coming from ISOLDE and a double Penning-trap system to first clean the ion samples and finally perform the mass measurements. Within this thesis the masses of neutron rich xenon and radon isotopes, namely $^{138-146}$Xe and $^{223-229}$Rn were determined, eleven of them for the first time. $^{229}$Rn was even discovered in this experiment and its half-life could be determined to roughly 12$^{+1.2}_{-1.3}$ s. Since the mass reflects all interactions inside the nucleus it is a unique...

  6. Renal MR angiography and perfusion in the pig using hyperpolarized water.

    Science.gov (United States)

    Wigh Lipsø, Kasper; Hansen, Esben Søvsø Szocska; Tougaard, Rasmus Stilling; Laustsen, Christoffer; Ardenkjaer-Larsen, Jan Henrik

    2017-09-01

    To study hyperpolarized water as an angiography and perfusion tracer in a large animal model. Protons dissolved in deuterium oxide (D 2 O) were hyperpolarized in a SPINlab dissolution dynamic nuclear polarization (dDNP) polarizer and subsequently investigated in vivo in a pig model at 3 Tesla (T). Approximately 15 mL of hyperpolarized water was injected in the renal artery by hand over 4-5 s. A liquid state polarization of 5.3 ± 0.9% of 3.8 M protons in 15 mL of deuterium oxide was achieved with a T 1 of 24 ± 1 s. This allowed injection through an arterial catheter into the renal artery and subsequently high-contrast imaging of the entire kidney parenchyma over several seconds. The dynamic images allow quantification of tissue perfusion, with a mean cortical perfusion of 504 ± 123 mL/100 mL/min. Hyperpolarized water MR imaging was successfully demonstrated as a renal angiography and perfusion method. Quantitative perfusion maps of the kidney were obtained in agreement with literature and control experiments with gadolinium contrast. Magn Reson Med 78:1131-1135, 2017. © 2016 International Society for Magnetic Resonance in Medicine. © 2016 International Society for Magnetic Resonance in Medicine.

  7. Regional quantification of lung function in cystic fibrosis using hyperpolarized xenon-129 and chemical shift imaging

    OpenAIRE

    Fernandes, Carolina Campanha

    2012-01-01

    Tese de mestrado em Engenharia Biomédica e Biofísica (Radiações em Diagnóstico e Terapia), apresentada à Universidade de Lisboa, através da Faculdade de Ciências, 2012 Cystic fibrosis (CF) is a genetic disorder in which the defective gene causes the production of unusually thick and viscous mucus that builds-up in the airways, leading to impaired ventilation and infection of lung structures. Currently, there is a lack of methods capable of routinely assessing, in a regional manner, basic p...

  8. Genealogical series method. Hyperpolar points screen effect

    International Nuclear Information System (INIS)

    Gorbatov, A.M.

    1991-01-01

    The fundamental values of the genealogical series method -the genealogical integrals (sandwiches) have been investigated. The hyperpolar points screen effect has been found. It allows one to calculate the sandwiches for the Fermion systems with large number of particles and to ascertain the validity of the iterated-potential method as well. For the first time the genealogical-series method has been realized numerically for the central spin-independent potential

  9. Hyperpolarized H2O MR angiography

    DEFF Research Database (Denmark)

    Ardenkjær-Larsen, Jan Henrik; Laustsen, Christoffer; Bowen, Sean

    2014-01-01

    polarization followed by dissolution in D2O. A water 1H signal enhancement of 77 times compared with 4.7 Tesla was obtained. This corresponds to a polarization of 3.5% for the 3.9 mol/L 1H in D2O . Moreover, a T1 in excess of 20 s was achieved. The use of hyperpolarized water as a contrast agent presents a new...

  10. Nuclear structure studies in the xenon and radon region and the discovery of a new radon isotope by Penning trap mass spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Neidherr, Dennis

    2010-04-28

    Nowadays high-precision mass measurements based on Penning traps allow a deep insight into the fundamental properties of nucleonic matter. To this end, the cyclotron frequency {nu}{sub c}=qB=(2{pi}m) of an ion confined in a strong, homogeneous magnetic field B is determined. At the ISOLTRAP mass spectrometer at ISOLDE / CERN the masses of short-lived radioactive nuclei with half-lives down to several ten ms can be measured with an uncertainty in the order of 10{sup -8} and below. ISOLTRAP consists of an RFQ cooler and buncher to cool and accumulate the ions coming from ISOLDE and a double Penning trap system to first clean the ion samples and finally perform the mass measurements. Within this thesis the masses of neutron rich xenon and radon isotopes, namely {sup 138-146}Xe and {sup 223-229}Rn were determined, eleven of them for the first time. {sup 229}Rn was even discovered in this experiment and its half-life could be determined to 12{sub -1.3}{sup +1.2} s. Since the mass reflects all interactions inside the nucleus it is a unique fingerprint of the nuclide of interest. One of these interactions, the proton-neutron interaction, leads for example to the onset of deformation. The aim of this thesis is to investigate a possible connection be- tween collective effects in nuclei, like the onset of deformation, and double-differences of binding energies, so called {delta}V{sub pn} values. Especially in the here presented areas these {delta}V{sub pn} values show a very unusual behavior and can not be explained with simple orbital overlapping arguments. One explanation could be the occurrence of octupolar deformation in these regions, which is usually probed with other experimental techniques. However, a quantitative description of the influence of such type of deformation on {delta}V{sub pn} is still not possible with modern theories. (orig.)

  11. Nuclear structure studies in the xenon and radon region and the discovery of a new radon isotope by Penning trap mass spectrometry

    International Nuclear Information System (INIS)

    Neidherr, Dennis

    2010-01-01

    Nowadays high-precision mass measurements based on Penning traps allow a deep insight into the fundamental properties of nucleonic matter. To this end, the cyclotron frequency ν c =qB=(2πm) of an ion confined in a strong, homogeneous magnetic field B is determined. At the ISOLTRAP mass spectrometer at ISOLDE / CERN the masses of short-lived radioactive nuclei with half-lives down to several ten ms can be measured with an uncertainty in the order of 10 -8 and below. ISOLTRAP consists of an RFQ cooler and buncher to cool and accumulate the ions coming from ISOLDE and a double Penning trap system to first clean the ion samples and finally perform the mass measurements. Within this thesis the masses of neutron rich xenon and radon isotopes, namely 138-146 Xe and 223-229 Rn were determined, eleven of them for the first time. 229 Rn was even discovered in this experiment and its half-life could be determined to 12 -1.3 +1.2 s. Since the mass reflects all interactions inside the nucleus it is a unique fingerprint of the nuclide of interest. One of these interactions, the proton-neutron interaction, leads for example to the onset of deformation. The aim of this thesis is to investigate a possible connection be- tween collective effects in nuclei, like the onset of deformation, and double-differences of binding energies, so called δV pn values. Especially in the here presented areas these δV pn values show a very unusual behavior and can not be explained with simple orbital overlapping arguments. One explanation could be the occurrence of octupolar deformation in these regions, which is usually probed with other experimental techniques. However, a quantitative description of the influence of such type of deformation on δV pn is still not possible with modern theories. (orig.)

  12. Characterization and optimization of the visualization performance of continuous flow overhauser DNP hyperpolarized water MRI: Inversion recovery approach.

    Science.gov (United States)

    Terekhov, Maxim; Krummenacker, Jan; Denysenkov, Vasyl; Gerz, Kathrin; Prisner, Thomas; Schreiber, Laura Maria

    2016-03-01

    Overhauser dynamic nuclear polarization (DNP) allows the production of liquid hyperpolarized substrate inside the MRI magnet bore as well as its administration in continuous flow mode to acquire MR images with enhanced signal-to-noise ratio. We implemented inversion recovery preparation in order to improve contrast-to-noise ratio and to quantify the overall imaging performance of Overhauser DNP-enhanced MRI. The negative enhancement created by DNP in combination with inversion recovery (IR) preparation allows canceling selectively the signal originated from Boltzmann magnetization and visualizing only hyperpolarized fluid. The theoretical model describing gain of MR image intensity produced by steady-state continuous flow DNP hyperpolarized magnetization was established and proved experimentally. A precise quantification of signal originated purely from DNP hyperpolarization was achieved. A temperature effect on longitudinal relaxation had to be taken into account to fit experimental results with numerical prediction. Using properly adjusted IR preparation, the complete zeroing of thermal background magnetization was achieved, providing an essential increase of contrast-to-noise ratio of DNP-hyperpolarized water images. To quantify and optimize the steady-state conditions for MRI with continuous flow DNP, an approach similar to that incorporating transient-state thermal magnetization equilibrium in spoiled fast field echo imaging sequences can be used. © 2015 Wiley Periodicals, Inc.

  13. Probing cardiac metabolism by hyperpolarized 13C MR using an exclusively endogenous substrate mixture and photo-induced nonpersistent radicals

    DEFF Research Database (Denmark)

    Bastiaansen, Jessica A M; Yoshihara, Hikari A I; Capozzi, Andrea

    2018-01-01

    dissolved, and the radical-free hyperpolarized solution was rapidly transferred into an injection pump located inside a 9.4T scanner. The hyperpolarized solution was injected in healthy rats to measure cardiac metabolism in vivo. Ultraviolet irradiation created nonpersistent radicals in a mixture containing......To probe the cardiac metabolism of carbohydrates and short chain fatty acids simultaneously in vivo following the injection of a hyperpolarized 13 C-labeled substrate mixture prepared using photo-induced nonpersistent radicals. Droplets of mixed [1-13 C]pyruvic and [1-13 C]butyric acids were frozen...... into glassy beads in liquid nitrogen. Ethanol addition was investigated as a means to increase the polarization level. The beads were irradiated with ultraviolet light and the radical concentration was measured by ESR spectroscopy. Following dynamic nuclear polarization in a 7T polarizer, the beads were...

  14. Optimal control of xenon concentration by observer design under reactor model uncertainty

    International Nuclear Information System (INIS)

    Cho, Nam Z.; Yang, Chae Y.; Woo, Hae S.

    1989-01-01

    The state feedback in control theory enjoys many advantages, such as stabilization and improved transient response, which could be beneficially used for control of the xenon oscillation in a power reactor. It is, however, not possible in nuclear reactors to measure the state variables, such as xenon and iodine concentrations. For implementation of the optimal state feedback control law, it is thus necessary to estimate the unmeasurable state variables. This paper uses the Luenberger observer to estimate the xenon and iodine concentrations to be used in a linear quadratic problem with state feedback. To overcome the stiffness problem in reactor kinetics, a singular perturbation method is used

  15. Xenon-Water Interaction in Bacterial Suspensions as Studied by NMR

    DEFF Research Database (Denmark)

    Rodin, V.; Ponomarev, Alexander; Gerasimov, Maxim

    2017-01-01

    suspensions of Escherichia coli in the presence of xenon using nuclear magnetic resonance (NMR). The work studied how the spin-lattice relaxation times of water protons in suspension change under xenon conditions. Xenon is able to form clathrate hydrates with water molecules at a temperature above the melting...... point of ice. The work studied NMR relaxation times which reflect the rotation freedom of water molecules in suspension. Lower relaxation times indicate reduced rotational freedom of water. Single exponential behavior of spin-lattice relaxation of protons in the suspensions of microorganisms has been...

  16. Operation and technology development of the radioactive xenon and krypton detection equipment

    International Nuclear Information System (INIS)

    Lee, Wanno; Choi, Sangdo; Ji, Youngyong; Lim, Jong Myoung; Cho, Young Hyun; Kang, Han Beul; Lee, Hoon; Kang, Moon Ja; Choi, Kun Sik

    2013-03-01

    Operation and technology development of the radioactive xenon and krypton detection equipment - Advancement, independence of operation technology for BfS-IAR system(the simultaneous analysis of xenon and krypton) installed after North Korea nuclear tests in 2006 and establishment of background base-line for xenon and krypton radioactivity. - Enhanced detection and analysis capabilities for neighborhood nuclear activities through advanced research of noble gas detection technology. Results of the Project · The operation of xenon and krypton analysis system (BfS-IAR) · Operation of fixed adsorption system. · Operation of portable adsorption system · Exercise of emergency response and proficiency test with SAUNA. · Measurement of noble gas background at specific region in Korea. - Radioxenon levels at Dongdu Cheon is approximately 1.6 mBq/m 3 · Development of automation filling system for absorber cooling

  17. On the spin-dependent sensitivity of XENON100

    Energy Technology Data Exchange (ETDEWEB)

    Garny, Mathias [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Ibarra, Alejandro; Pato, Miguel; Vogl, Stefan [Technische Univ. Muenchen, Garching (Germany). Physik-Department

    2012-11-15

    The latest XENON100 data severely constrains dark matter elastic scattering off nuclei, leading to impressive upper limits on the spin-independent cross-section. The main goal of this paper is to stress that the same data set has also an excellent spin-dependent sensitivity, which is of utmost importance in probing dark matter models. We show in particular that the constraints set by XENON100 on the spin-dependent neutron cross-section are by far the best at present, whereas the corresponding spin-dependent proton limits lag behind other direct detection results. The effect of nuclear uncertainties on the structure functions of xenon isotopes is analysed in detail and found to lessen the robustness of the constraints, especially for spin-dependent proton couplings. Notwith-standing, the spin-dependent neutron prospects for XENON1T and DARWIN are very encouraging. We apply our constraints to well-motivated dark matter models and demonstrate that in both mass-degenerate scenarios and the minimal supersymmetric standard model the spin-dependent neutron limits can actually override the spin-independent limits. This opens the possibility of probing additional unexplored regions of the dark matter parameter space with the next generation of ton-scale direct detection experiments.

  18. On the spin-dependent sensitivity of XENON100

    International Nuclear Information System (INIS)

    Garny, Mathias; Ibarra, Alejandro; Pato, Miguel; Vogl, Stefan

    2012-11-01

    The latest XENON100 data severely constrains dark matter elastic scattering off nuclei, leading to impressive upper limits on the spin-independent cross-section. The main goal of this paper is to stress that the same data set has also an excellent spin-dependent sensitivity, which is of utmost importance in probing dark matter models. We show in particular that the constraints set by XENON100 on the spin-dependent neutron cross-section are by far the best at present, whereas the corresponding spin-dependent proton limits lag behind other direct detection results. The effect of nuclear uncertainties on the structure functions of xenon isotopes is analysed in detail and found to lessen the robustness of the constraints, especially for spin-dependent proton couplings. Notwith-standing, the spin-dependent neutron prospects for XENON1T and DARWIN are very encouraging. We apply our constraints to well-motivated dark matter models and demonstrate that in both mass-degenerate scenarios and the minimal supersymmetric standard model the spin-dependent neutron limits can actually override the spin-independent limits. This opens the possibility of probing additional unexplored regions of the dark matter parameter space with the next generation of ton-scale direct detection experiments.

  19. Study of xenon binding in cryptophane-A using laser-induced NMR polarization enhancement

    International Nuclear Information System (INIS)

    Luhmer, M.; Goodson, B.M.; Song, Y.Q.; Laws, D.D.; Kaiser, L.; Pines, A.; Lawrence Berkeley National Lab., CA

    1999-01-01

    Xenon is chemically inert, yet exhibits NMR parameters that are highly sensitive to its chemical environment. Considerable work has therefore capitalized on the utility of 129 Xe (I = 1/2) as a magnetic resonance probe of molecules, materials, and biological systems. In solution, spin-polarization transfer between laser-polarized xenon and the hydrogen nuclei of nearby molecules leads to signal enhancements in the resolved 1 H NMR spectrum, offering new opportunities for probing the chemical environment of xenon atoms. Following binding of laser-polarized xenon to molecules of cryptophane-A, selective enhancements of the 1 H NMR signals were observed. A theoretical framework for the interpretation of such experimental results is provided, and the spin polarization-induced nuclear Overhauser effects are shown to yield information about the molecular environment of xenon. The observed selective 1 H enhancements allowed xenon-proton internuclear distances to be estimated. These distances reveal structural characteristics of the complex, including the preferred molecular conformations adopted by cryptophane-A upon binding of xenon

  20. Dynamic adsorption properties of xenon on activated carbons and their structure characterization

    International Nuclear Information System (INIS)

    Liu Suiqing; Liu Jing; Qian Yuan; Zeng Youshi; Du Lin; Pi Li; Liu Wei

    2013-01-01

    Background: In recent years, adsorption of radioactive xenon by activated carbon has been increasingly applied to the treatment of off-gas in nuclear power project. Though pore structure of activated carbon has a great impact on its dynamic adsorption coefficients for xenon, the concerned research is rare. Purpose: It is very necessary to figure out the relationship between the pore structure and the dynamic adsorption coefficients for the purpose of the selection and development of activated carbon. Methods: In this study, the dynamic adsorption coefficients of xenon on four kinds of activated carbons were measured on a dynamic adsorption platform under the condition of 25℃, OMPa (gauge pressure). And these four kinds of activated carbons were characterized by nitrogen adsorption and SEM. Results: The results show that the activated carbon of JH12-16 with the specific surface area of 991.9 m 2 ·g -1 has the largest xenon dynamic adsorption coefficient among these activated carbons. Conclusions: The dynamic adsorption coefficient of xenon on activated carbon doesn't increase with the specific surface area or the pore volume. The mesopore and macropore only play the role of passageway for xenon adsorption. The most suitable pore for xenon adsorption is the pore with the pore size ranged from 0.55 to 0.6 nm. (authors)

  1. Direct hyperpolarization of micro- and nanodiamonds for bioimaging applications - Considerations on particle size, functionalization and polarization loss

    Science.gov (United States)

    Kwiatkowski, Grzegorz; Jähnig, Fabian; Steinhauser, Jonas; Wespi, Patrick; Ernst, Matthias; Kozerke, Sebastian

    2018-01-01

    Due to the inherently long relaxation time of 13C spins in diamond, the nuclear polarization enhancement obtained with dynamic nuclear polarization can be preserved for a time on the order of about one hour, opening up an opportunity to use diamonds as a new class of long-lived contrast agents. The present communication explores the feasibility of using 13C spins in directly hyperpolarized diamonds for MR imaging including considerations for potential in vivo applications.

  2. An approach to stability analysis of spatial xenon oscillations in WWER-1000 reactors

    International Nuclear Information System (INIS)

    Parhizkari, H.; Aghaie, M.; Zolfaghari, A.; Minuchehr, A.

    2015-01-01

    Highlights: • The multipoint methodology is developed for xenon oscillation in the BNPP. • The axial, radial and azimuthal offsets are calculated in the BOC and EOC. • It is shown that the all of oscillation modes are safe in the BOC. • The axial oscillation is not safe in the EOC and needs governor control system. • The multipoint kinetics show good agreement for spatial oscillations. - Abstract: Spatial power oscillations due to spatial distribution of xenon transient are well known as xenon oscillation in large reactors. Xenon-induced spatial power oscillations occur as a result of rapid perturbations to power distribution that cause the xenon and iodine distribution to be out of phase with the perturbed power distribution. This results in a shift in xenon and iodine distributions that causes the power distribution to change in an opposite direction from the initial perturbation. In this paper xenon-induced power oscillation is described by a system of differential equations with non-linearity between xenon and flux distributions; the dynamics of process is described by a discrete distributed parameter model, with the neutron flux, the delayed neutrons, the core temperature and the xenon and iodine concentrations as the “states” of the system. It is shown that it is possible to describe the discrete distributed-parameter as a set of coupled point-reactor models. It is also shown that using this scheme it is possible to analyze the control aspects of a multi-section large core reactor by treating only two adjacent sections of the core. To illustrate the capability and efficiency of the proposed scheme Bushehr Nuclear Power Plant, BNPP, which is a WWER-1000 reactor, is chosen to show the performance of the methodology. The axial, azimuthal and radial power oscillation at the beginning of cycle, BOC, and the end of cycle, EOC, for BNPP are investigated; the results are in good agreement with safety analysis report of the reference plant

  3. Gravity assisted recovery of liquid xenon at large mass flow rates

    Science.gov (United States)

    Virone, L.; Acounis, S.; Beaupère, N.; Beney, J.-L.; Bert, J.; Bouvier, S.; Briend, P.; Butterworth, J.; Carlier, T.; Chérel, M.; Crespi, P.; Cussonneau, J.-P.; Diglio, S.; Manzano, L. Gallego; Giovagnoli, D.; Gossiaux, P.-B.; Kraeber-Bodéré, F.; Ray, P. Le; Lefèvre, F.; Marty, P.; Masbou, J.; Morteau, E.; Picard, G.; Roy, D.; Staempflin, M.; Stutzmann, J.-S.; Visvikis, D.; Xing, Y.; Zhu, Y.; Thers, D.

    2018-06-01

    We report on a liquid xenon gravity assisted recovery method for nuclear medical imaging applications. The experimental setup consists of an elevated detector enclosed in a cryostat connected to a storage tank called ReStoX. Both elements are part of XEMIS2 (XEnon Medical Imaging System): an innovative medical imaging facility for pre-clinical research that uses pure liquid xenon as detection medium. Tests based on liquid xenon transfer from the detector to ReStoX have been successfully performed showing that an unprecedented mass flow rate close to 1 ton per hour can be reached. This promising achievement as well as future areas of improvement will be discussed in this paper.

  4. An investigation of axial xenon stability in WWER-1000 reactor designs

    International Nuclear Information System (INIS)

    Doshi, P.K.; Miller, R.W.

    1993-01-01

    The nuclear power plants of the WWER-1000 design have experienced frequent xenon oscillation control problems. In most PWRs, xenon oscillations are largely a problem in the axial direction. An one dimensional core model representative of the WWER-1000 design was set up to examine the controllability of the current design. An investigation of possible improvements to this design was made. There was no indication that xenon oscillations were an inherent problem in WWER-1000 core design. Simple changes to the control rod system coupled with a sound power distribution control strategy that has been proven to be an effective but simple procedure to follow, eliminate xenon control problems. The changes proposed can be implemented in a very cost effective manner. There are no equipment changes needed, existing control rods can be used. Only software changes are required. (Z.S.) 1 tab., 2 figs., 7 refs

  5. Lowering the radioactivity of the photomultiplier tubes for the XENON1T dark matter experiment

    Energy Technology Data Exchange (ETDEWEB)

    Aprile, E.; Contreras, H.; Goetzke, L.W.; Fernandez, A.J.M.; Messina, M.; Plante, G.; Rizzo, A. [Columbia University, Physics Department, New York, NY (United States); Agostini, F. [INFN-Laboratori Nazionali del Gran Sasso (Italy); Gran Sasso Science Institute, L' Aquila (Italy); Bologna Univ., Department of Physics and Astrophysics, Bologna (Italy); INFN, Bologna (Italy); Alfonsi, M. [Nikhef and the University of Amsterdam, Amsterdam (Netherlands); Johannes Gutenberg-Universitaet Mainz, Institut fuer Physik and Exzellenzcluster PRISMA, Mainz (Germany); Arazi, L.; Budnik, R.; Duchovni, E.; Gross, E.; Itay, R.; Landsman, H.; Lellouch, D.; Levinson, L.; Priel, N.; Vitells, O. [Weizmann Institute of Science, Department of Particle Physics and Astrophysics, Rehovot (Israel); Arisaka, K.; Lyashenko, A.; Meng, Y.; Pantic, E.; Teymourian, A.; Wang, H. [University of California, Physics and Astronomy Department, Los Angeles, CA (United States); Arneodo, F.; Di Giovanni, A. [New York University Abu Dhabi, Abu Dhabi (United Arab Emirates); Auger, M.; Barrow, P.; Baudis, L.; Behrens, A.; Galloway, M.; Kessler, G.; Kish, A.; Mayani, D.; Pakarha, P.; Piastra, F. [University of Zurich, Physik-Institut, Zurich (Switzerland); Balan, C.; Cardoso, J.M.R.; Lopes, J.A.M.; Santos, J.M.F. dos [University of Coimbra, Department of Physics, Coimbra (Portugal); Bauermeister, B.; Fattori, S.; Geis, C.; Grignon, C.; Oberlack, U.; Schindler, S. [Johannes Gutenberg-Universitaet Mainz, Institut fuer Physik and Exzellenzcluster PRISMA, Mainz (Germany); Beltrame, P. [Weizmann Institute of Science, Department of Particle Physics and Astrophysics, Rehovot (Israel); University of Edinburgh, Edinburgh (United Kingdom); Brown, A.; Lang, R.F.; Macmullin, S.; Pienaar, J.; Reichard, S.; Reuter, C. [Purdue University, Department of Physics and Astronomy, West Lafayette, IN (United States); Brown, E.; Levy, C. [Rensselaer Polytechnic Institute, Department of Physics, Applied Physics and Astronomy, Troy, NY (United States); Wilhelms-Universitaet Muenster, Institut fuer Kernphysik, Muenster (Germany); Bruenner, S.; Hampel, W.; Kaether, F.; Lindemann, S.; Lindner, M.; Undagoitia, T.M.; Rauch, L.; Schreiner, J.; Simgen, H.; Weber, M. [Max-Planck-Institut fuer Kernphysik, Heidelberg (Germany); Bruno, G. [INFN-Laboratori Nazionali del Gran Sasso and Gran Sasso Science Institute, L' Aquila (Italy); Wilhelms-Universitaet Muenster, Institut fuer Kernphysik, Muenster (Germany); Buetikofer, L.; Coderre, D.; Schumann, M. [University of Bern, Albert Einstein Center for Fundamental Physics, Bern (Switzerland); Colijn, A.P.; Decowski, M.P.; Tiseni, A.; Tunnell, C. [Nikhef and the University of Amsterdam, Amsterdam (Netherlands); Cussonneau, J.P.; Le Calloch, M.; Masbou, J.; Lavina, L.S.; Thers, D. [Universite de Nantes, Subatech, Ecole des Mines de Nantes, CNRS/In2p3, Nantes (France); Ferella, A.D.; Fulgione, W.; Laubenstein, M. [INFN-Laboratori Nazionali del Gran Sasso and Gran Sasso Science Institute, L' Aquila (Italy); Fieguth, A.; Murra, M.; Rosendahl, S.; Weinheimer, C. [Wilhelms-Universitaet Muenster, Institut fuer Kernphysik, Muenster (Germany); Garbini, M.; Massoli, F.V.; Sartorelli, G.; Selvi, M. [Bologna Univ., Department of Physics and Astrophysics, Bologna (Italy); INFN, Bologna (Italy); Miguez, B.; Molinario, A.; Trinchero, G. [INFN-Torino and Osservatorio Astrofisico di Torino, Turin (Italy); Naganoma, J.; Shagin, P.; Wall, R. [Rice University, Department of Physics and Astronomy, Houston, TX (United States); Orrigo, S.E.A. [University of Coimbra, Department of Physics, Coimbra (Portugal); IFIC, CSIC-Universidad de Valencia, Valencia (Spain); Persiani, R. [Universite de Nantes, Subatech, Ecole des Mines de Nantes, CNRS/In2p3, Nantes (FR); Bologna Univ., Department of Physics and Astrophysics, Bologna (IT); INFN, Bologna (IT); Collaboration: XENON Collaboration

    2015-11-15

    The low-background, VUV-sensitive 3-inch diameter photomultiplier tube R11410 has been developed by Hamamatsu for dark matter direct detection experiments using liquid xenon as the target material. We present the results from the joint effort between the XENON collaboration and the Hamamatsu company to produce a highly radio-pure photosensor (version R11410-21) for the XENON1T dark matter experiment. After introducing the photosensor and its components, we show the methods and results of the radioactive contamination measurements of the individual materials employed in the photomultiplier production. We then discuss the adopted strategies to reduce the radioactivity of the various PMT versions. Finally, we detail the results from screening 286 tubes with ultra-low background germanium detectors, as well as their implications for the expected electronic and nuclear recoil background of the XENON1T experiment. (orig.)

  6. Xenon migration in UO{sub 2} under irradiation studied by SIMS profilometry

    Energy Technology Data Exchange (ETDEWEB)

    Marchand, B. [Université de Lyon, CNRS/IN2P3, Université Lyon 1, Institut de Physique Nucléaire de Lyon, 4 rue Enrico Fermi, F-69622 Villeurbanne cedex (France); AREVA, AREVA NP, 10 rue Juliette Récamier, F-69456 Lyon (France); Moncoffre, N. [Université de Lyon, CNRS/IN2P3, Université Lyon 1, Institut de Physique Nucléaire de Lyon, 4 rue Enrico Fermi, F-69622 Villeurbanne cedex (France); Pipon, Y., E-mail: pipon@ipnl.in2p3.fr [Université de Lyon, CNRS/IN2P3, Université Lyon 1, Institut de Physique Nucléaire de Lyon, 4 rue Enrico Fermi, F-69622 Villeurbanne cedex (France); Université de Lyon, Université Lyon 1, IUT Lyon 1, 43 bd du 11 novembre 1918, 69 622 Villeurbanne cedex (France); Bérerd, N. [Université de Lyon, CNRS/IN2P3, Université Lyon 1, Institut de Physique Nucléaire de Lyon, 4 rue Enrico Fermi, F-69622 Villeurbanne cedex (France); Université de Lyon, Université Lyon 1, IUT Lyon 1, 43 bd du 11 novembre 1918, 69 622 Villeurbanne cedex (France); Garnier, C. [AREVA, AREVA NP, 10 rue Juliette Récamier, F-69456 Lyon (France); Raimbault, L. [Ecole des Mines de Paris, Centre de Géosciences, 35 rue Saint Honoré, F-77305 Fontainebleau cedex (France); Sainsot, P. [Université de Lyon, Université Lyon 1, LaMCoS, INSA-Lyon, CNRS UMR5259, F-69621 Villeurbanne cedex (France); and others

    2013-09-15

    During Pressurized Water Reactor operation, around 25% of the created Fission Products (FP) are Xenon and Krypton. They have a low solubility in the nuclear fuel and can either (i) agglomerate into bubbles which induce mechanical stress in the fuel pellets or (ii) be released from the pellets, increasing the pressure within the cladding and decreasing the thermal conductivity of the gap between pellets and cladding. After fifty years of studies on the nuclear fuel, all mechanisms of Fission Gas Release (FGR) are still not fully understood. This paper aims at studying the FGR mechanisms by decoupling thermal and irradiation effects and by assessing the Xenon behavior for the first time by profilometry. Samples are first implanted with {sup 136}Xe at 800 keV corresponding to a projected range of 140 nm. They are then either annealed in the temperature range 1400–1600 °C, or irradiated with heavy energy ions (182 MeV Iodine) at Room Temperature (RT), 600 °C or 1000 °C. Depth profiles of implanted Xenon in UO{sub 2} are determined by Secondary Ion Mass Spectrometry (SIMS). It is shown that Xenon is mobile during irradiation at 1000 °C. In contrast, thermal treatments do not induce any Xenon migration process: these results are correlated to the formation of Xenon bubbles observed by Transmission Electron Microscopy.

  7. RESULTS FROM THE XENON100 EXPERIMENT

    Directory of Open Access Journals (Sweden)

    Rino Persiani

    2013-12-01

    Full Text Available The XENON program consists in operating and developing double-phase time projection chambers using liquid xenon as the target material. It aims to directly detect dark matter in the form of WIMPs via their elastic scattering off xenon nuclei. The current phase is XENON100, located at the Laboratori Nazionali del Gran Sasso (LNGS, with a 62 kg liquid xenon target. We present the 100.9 live days of data, acquired between January and June 2010, with no evidence of dark matter, as well as the new results of the last scientific run, with about 225 live days. The next phase, XENON1T, will increase the sensitivity by two orders of magnitude.

  8. Xenon preconditioning: molecular mechanisms and biological effects

    Directory of Open Access Journals (Sweden)

    Liu Wenwu

    2013-01-01

    Full Text Available Abstract Xenon is one of noble gases and has been recognized as an anesthetic for more than 50 years. Xenon possesses many of the characteristics of an ideal anesthetic, but it is not widely applied in clinical practice mainly because of its high cost. In recent years, numerous studies have demonstrated that xenon as an anesthetic can exert neuroprotective and cardioprotective effects in different models. Moreover, xenon has been applied in the preconditioning, and the neuroprotective and cardioprotective effects of xenon preconditioning have been investigated in a lot of studies in which some mechanisms related to these protections are proposed. In this review, we summarized these mechanisms and the biological effects of xenon preconditioning.

  9. Control aid for xenon vibration in reactor

    International Nuclear Information System (INIS)

    Kanekawa, Takashi.

    1990-01-01

    In the present invention, the control operation for suppressing xenon vibrations in a reactor is aided for saving forecasting analysis and operator's skills. That is, parameters to be controlled for the suppression of xenon vibrations are power distribution, iodine distribution and xenon distribution. But what can be observed by operaters by the conventional fast overtone method is only the output distribution. In the present invention, the output level of the reactor core is always observed. Then, mathematical processings are conducted for the iodine distribution, the xenon distribution and the power distribution in the reactor core based on the histeresis of the parameters obtained by the measurement using physical constants and reactor design data. The xenon vibration control is aided by displaying the change with time of the distortion in axial direction. Accordingly, operators can always recognize the axial distortion of the power distribution, the iodine distribution and the xenon distribution. (I.S.)

  10. Latest results from XENON100 data

    International Nuclear Information System (INIS)

    Scotto Lavina, L.

    2014-01-01

    XENON100 is the current phase of the XENON dark matter program, which aims for the direct detection of WIMPs with liquid xenon time-projection chambers. We present the status of the experiment after 224.6 live days taken in 2011 and 2012 during which the detector successfully improved in terms of more calibration data, higher xenon purity, lower threshold and better background removal. The analysis has yielded no evidence for dark matter interactions. The status of the next generation XENON1T detector will be briefly described. The goal of XENON1T is to increase the fiducial volume by a factor 10 and reduce the background noise by a factor 100

  11. Xenon changes under power-burst conditions

    International Nuclear Information System (INIS)

    Diamond, D.J.

    1983-01-01

    Under ordinary operating conditions the xenon concentration in a reactor core can change significantly in times on the order of hours. Core transients of safety significance are much more rapid and hence calculations are done with xenon concentration held constant. However, in certain transients (such as reactivity initiated accidents) there is a very large power surge and the question arises as to whether under these circumstances the xenon concentration could change. This would be particularly important if the xenon were reduced thereby tending to make the accident autocatalytic. The objective of the present study is to quantify this effect to see if it could be important

  12. The XENON1T dark matter experiment

    Science.gov (United States)

    Aprile, E.; Aalbers, J.; Agostini, F.; Alfonsi, M.; Amaro, F. D.; Anthony, M.; Antunes, B.; Arneodo, F.; Balata, M.; Barrow, P.; Baudis, L.; Bauermeister, B.; Benabderrahmane, M. L.; Berger, T.; Breskin, A.; Breur, P. A.; Brown, A.; Brown, E.; Bruenner, S.; Bruno, G.; Budnik, R.; Bütikofer, L.; Calvén, J.; Cardoso, J. M. R.; Cervantes, M.; Chiarini, A.; Cichon, D.; Coderre, D.; Colijn, A. P.; Conrad, J.; Corrieri, R.; Cussonneau, J. P.; Decowski, M. P.; de Perio, P.; Gangi, P. Di; Giovanni, A. Di; Diglio, S.; Disdier, J.-M.; Doets, M.; Duchovni, E.; Eurin, G.; Fei, J.; Ferella, A. D.; Fieguth, A.; Franco, D.; Front, D.; Fulgione, W.; Rosso, A. Gallo; Galloway, M.; Gao, F.; Garbini, M.; Geis, C.; Giboni, K.-L.; Goetzke, L. W.; Grandi, L.; Greene, Z.; Grignon, C.; Hasterok, C.; Hogenbirk, E.; Huhmann, C.; Itay, R.; James, A.; Kaminsky, B.; Kazama, S.; Kessler, G.; Kish, A.; Landsman, H.; Lang, R. F.; Lellouch, D.; Levinson, L.; Lin, Q.; Lindemann, S.; Lindner, M.; Lombardi, F.; Lopes, J. A. M.; Maier, R.; Manfredini, A.; Maris, I.; Undagoitia, T. Marrodán; Masbou, J.; Massoli, F. V.; Masson, D.; Mayani, D.; Messina, M.; Micheneau, K.; Molinario, A.; Morå, K.; Murra, M.; Naganoma, J.; Ni, K.; Oberlack, U.; Orlandi, D.; Othegraven, R.; Pakarha, P.; Parlati, S.; Pelssers, B.; Persiani, R.; Piastra, F.; Pienaar, J.; Pizzella, V.; Piro, M.-C.; Plante, G.; Priel, N.; García, D. Ramírez; Rauch, L.; Reichard, S.; Reuter, C.; Rizzo, A.; Rosendahl, S.; Rupp, N.; Santos, J. M. F. dos; Saldanha, R.; Sartorelli, G.; Scheibelhut, M.; Schindler, S.; Schreiner, J.; Schumann, M.; Lavina, L. Scotto; Selvi, M.; Shagin, P.; Shockley, E.; Silva, M.; Simgen, H.; Sivers, M. v.; Stern, M.; Stein, A.; Tatananni, D.; Tatananni, L.; Thers, D.; Tiseni, A.; Trinchero, G.; Tunnell, C.; Upole, N.; Vargas, M.; Wack, O.; Walet, R.; Wang, H.; Wang, Z.; Wei, Y.; Weinheimer, C.; Wittweg, C.; Wulf, J.; Ye, J.; Zhang, Y.

    2017-12-01

    The XENON1T experiment at the Laboratori Nazionali del Gran Sasso (LNGS) is the first WIMP dark matter detector operating with a liquid xenon target mass above the ton-scale. Out of its 3.2 t liquid xenon inventory, 2.0 t constitute the active target of the dual-phase time projection chamber. The scintillation and ionization signals from particle interactions are detected with low-background photomultipliers. This article describes the XENON1T instrument and its subsystems as well as strategies to achieve an unprecedented low background level. First results on the detector response and the performance of the subsystems are also presented.

  13. Xenon Fractionation and Archean Hydrogen Escape

    Science.gov (United States)

    Zahnle, K. J.

    2015-01-01

    Xenon is the heaviest gas found in significant quantities in natural planetary atmospheres. It would seem the least likely to escape. Yet there is more evidence for xenon escape from Earth than for any element other than helium and perhaps neon. The most straightforward evidence is that most of the radiogenic Xe from the decay of (129)I (half-life 15.7 Myr) and (244)Pu (half-life 81 Myr) that is Earth's birthright is missing. The missing xenon is often attributed to the impact erosion of early atmospheres of Earth and its ancestors. It is obvious that if most of the radiogenic xenon were driven off by impacts, most of the rest of the atmophiles fared the same fate. The other line of evidence is in the nonradiogenic isotopes of xenon and its silent partner, krypton. Atmospheric xenon is strongly mass fractionated (at about 4% per amu) compared to any known solar system source (Figure 1). This is in stark contrast to krypton, which may not be fractionated at all: atmospheric Kr is slightly heavier than solar Kr (at about 0.5% per amu), but it is the same as in carbonaceous chondrites. Nonradiogenic xenon is also under abundant relative to krypton (the so-called "missing xenon" problem). Together these observations imply that xenon has been subject to fractionating escape and krypton not.

  14. The XENON1T dark matter experiment

    Energy Technology Data Exchange (ETDEWEB)

    Aprile, E.; Anthony, M.; De Perio, P.; Gao, F.; Giboni, K.L.; Goetzke, L.W.; Greene, Z.; Lin, Q.; Plante, G.; Rizzo, A.; Stern, M.; Tatananni, D.; Zhang, Y. [Columbia University, Physics Department, New York, NY (United States); Aalbers, J.; Breur, P.A.; Brown, A.; Colijn, A.P.; Decowski, M.P.; Doets, M.; Hogenbirk, E.; Tiseni, A.; Walet, R. [Nikhef and the University of Amsterdam, Amsterdam (Netherlands); Agostini, F. [INFN-Laboratori Nazionali del Gran Sasso, L' Aquila (Italy); Gran Sasso Science Institute, L' Aquila (Italy); University of Bologna, Department of Physics and Astrophysics (Italy); INFN-Bologna (Italy); Alfonsi, M.; Geis, C.; Grignon, C.; Oberlack, U.; Othegraven, R.; Scheibelhut, M.; Schindler, S. [Johannes Gutenberg-Universitaet Mainz, Institut fuer Physik and Exzellenzcluster PRISMA, Mainz (Germany); Amaro, F.D.; Antunes, B.; Cardoso, J.M.R.; Lopes, J.A.M.; Santos, J.M.F. dos; Silva, M. [University of Coimbra, LIBPhys, Department of Physics, Coimbra (Portugal); Arneodo, F.; Benabderrahmane, M.L.; Di Giovanni, A.; Maris, I. [New York University Abu Dhabi, Abu Dhabi (United Arab Emirates); Balata, M.; Bruno, G.; Corrieri, R.; Disdier, J.M.; Rosso, A.G.; Molinario, A.; Orlandi, D.; Parlati, S.; Tatananni, L.; Wang, Z. [INFN-Laboratori Nazionali del Gran Sasso, L' Aquila (Italy); Gran Sasso Science Institute, L' Aquila (Italy); Barrow, P.; Baudis, L.; Franco, D.; Galloway, M.; James, A.; Kazama, S.; Kessler, G.; Kish, A.; Maier, R.; Mayani, D.; Pakarha, P.; Piastra, F.; Wulf, J. [University of Zurich, Physik Institut, Zurich (Switzerland); Bauermeister, B.; Calven, J.; Conrad, J.; Ferella, A.D.; Moraa, K.; Pelssers, B. [Stockholm University, AlbaNova, Oskar Klein Centre, Department of Physics, Stockholm (Sweden); Berger, T.; Brown, E.; Piro, M.C. [Rensselaer Polytechnic Institute, Department of Physics, Applied Physics and Astronomy, Troy, NY (United States); Breskin, A.; Budnik, R.; Duchovni, E.; Front, D.; Itay, R.; Landsman, H.; Lellouch, D.; Levinson, L.; Manfredini, A.; Priel, N. [Weizmann Institute of Science, Department of Particle Physics and Astrophysics, Rehovot (Israel); Bruenner, S.; Cichon, D.; Eurin, G.; Hasterok, C.; Lindner, M.; Undagoitia, T.M.; Pizzella, V.; Rauch, L.; Rupp, N.; Schreiner, J.; Simgen, H.; Wack, O. [Max-Planck-Institut fuer Kernphysik, Heidelberg (Germany); Buetikofer, L.; Coderre, D.; Kaminsky, B.; Schumann, M. [Universitaet Freiburg, Physikalisches Institut, Freiburg (Germany); Sivers, M. von [Freiburg Univ. (Germany). Physikalisches Inst.; Bern Univ. (Switzerland). Albert Einstein Center for Fundamental Physics; Cervantes, M.; Lang, R.F.; Masson, D.; Reuter, C. [Purdue University, Department of Physics and Astronomy, West Lafayette, IN (United States); Chiarini, A.; Di Gangi, P.; Garbini, M.; Massoli, F.V.; Sartorelli, G.; Selvi, M. [University of Bologna, Department of Physics and Astrophysics, Bologna (Italy); INFN-Bologna (Italy); Cussonneau, J.P.; Diglio, S.; Masbou, J.; Micheneau, K.; Persiani, R.; Thers, D. [CNRS/IN2P3, Universite de Nantes, SUBATECH, IMT Atlantique, Nantes (France); Fei, J.; Lombardi, F.; Ni, K.; Ye, J. [University of California, Department of Physics, San Diego, CA (United States); Fieguth, A.; Huhmann, C.; Murra, M.; Rosendahl, S.; Vargas, M.; Weinheimer, C.; Wittweg, C. [Westfaelische Wilhelms-Universitaet Muenster, Institut fuer Kernphysik, Muenster (Germany); Fulgione, W. [INFN-Laboratori Nazionali del Gran Sasso, L' Aquila (Italy); Gran Sasso Science Institute, L' Aquila (Italy); INFN-Torino (Italy); Osservatorio Astrofisico di Torino, Turin (Italy); Grandi, L.; Saldanha, R.; Shockley, E.; Tunnell, C.; Upole, N. [University of Chicago, Department of Physics and Kavli Institute of Cosmological Physics, Chicago, IL (United States); Lindemann, S. [Max-Planck-Institut fuer Kernphysik, Heidelberg (Germany); Universitaet Freiburg, Physikalisches Institut, Freiburg (Germany); Messina, M. [Columbia University, Physics Department, New York, NY (United States); New York University Abu Dhabi, Abu Dhabi (United Arab Emirates); Naganoma, J.; Shagin, P. [Rice University, Department of Physics and Astronomy, Houston, TX (United States); Pienaar, J. [Purdue University, Department of Physics and Astronomy, West Lafayette, IN (United States); University of Chicago, Department of Physics and Kavli Institute of Cosmological Physics, Chicago, IL (United States); Garcia, D.R. [Johannes Gutenberg-Universitaet Mainz, Institut fuer Physik and Exzellenzcluster PRISMA, Mainz (Germany); Universitaet Freiburg, Physikalisches Institut, Freiburg (Germany); Reichard, S. [University of Zurich, Physik Institut, Zurich (Switzerland); Purdue University, Department of Physics and Astronomy, West Lafayette, IN (United States); Lavina, L.S. [Universite Pierre et Marie Curie, Universite Paris Diderot, CNRS/IN2P3, LPNHE, Paris (France); Stein, A.; Wang, H. [University of California, Physics and Astronomy Department, Los Angeles, CA (United States); Trinchero, G. [INFN-Torino (Italy); Osservatorio Astrofisico di Torino, Turin (Italy); Wei, Y. [University of Zurich, Physik Institut, Zurich (Switzerland); University of California, Department of Physics, San Diego, CA (United States); Collaboration: XENON Collaboration

    2017-12-15

    The XENON1T experiment at the Laboratori Nazionali del Gran Sasso (LNGS) is the first WIMP dark matter detector operating with a liquid xenon target mass above the ton-scale. Out of its 3.2 t liquid xenon inventory, 2.0 t constitute the active target of the dual-phase time projection chamber. The scintillation and ionization signals from particle interactions are detected with low-background photomultipliers. This article describes the XENON1T instrument and its subsystems as well as strategies to achieve an unprecedented low background level. First results on the detector response and the performance of the subsystems are also presented. (orig.)

  15. The XENON1T dark matter experiment

    International Nuclear Information System (INIS)

    Aprile, E.; Anthony, M.; De Perio, P.; Gao, F.; Giboni, K.L.; Goetzke, L.W.; Greene, Z.; Lin, Q.; Plante, G.; Rizzo, A.; Stern, M.; Tatananni, D.; Zhang, Y.; Aalbers, J.; Breur, P.A.; Brown, A.; Colijn, A.P.; Decowski, M.P.; Doets, M.; Hogenbirk, E.; Tiseni, A.; Walet, R.; Agostini, F.; Alfonsi, M.; Geis, C.; Grignon, C.; Oberlack, U.; Othegraven, R.; Scheibelhut, M.; Schindler, S.; Amaro, F.D.; Antunes, B.; Cardoso, J.M.R.; Lopes, J.A.M.; Santos, J.M.F. dos; Silva, M.; Arneodo, F.; Benabderrahmane, M.L.; Di Giovanni, A.; Maris, I.; Balata, M.; Bruno, G.; Corrieri, R.; Disdier, J.M.; Rosso, A.G.; Molinario, A.; Orlandi, D.; Parlati, S.; Tatananni, L.; Wang, Z.; Barrow, P.; Baudis, L.; Franco, D.; Galloway, M.; James, A.; Kazama, S.; Kessler, G.; Kish, A.; Maier, R.; Mayani, D.; Pakarha, P.; Piastra, F.; Wulf, J.; Bauermeister, B.; Calven, J.; Conrad, J.; Ferella, A.D.; Moraa, K.; Pelssers, B.; Berger, T.; Brown, E.; Piro, M.C.; Breskin, A.; Budnik, R.; Duchovni, E.; Front, D.; Itay, R.; Landsman, H.; Lellouch, D.; Levinson, L.; Manfredini, A.; Priel, N.; Bruenner, S.; Cichon, D.; Eurin, G.; Hasterok, C.; Lindner, M.; Undagoitia, T.M.; Pizzella, V.; Rauch, L.; Rupp, N.; Schreiner, J.; Simgen, H.; Wack, O.; Buetikofer, L.; Coderre, D.; Kaminsky, B.; Schumann, M.; Sivers, M. von; Chiarini, A.; Di Gangi, P.; Garbini, M.; Massoli, F.V.; Sartorelli, G.; Selvi, M.; Cussonneau, J.P.; Diglio, S.; Masbou, J.; Micheneau, K.; Persiani, R.; Thers, D.; Fei, J.; Lombardi, F.; Ni, K.; Ye, J.; Fieguth, A.; Huhmann, C.; Murra, M.; Rosendahl, S.; Vargas, M.; Weinheimer, C.; Wittweg, C.; Fulgione, W.; Grandi, L.; Saldanha, R.; Shockley, E.; Tunnell, C.; Upole, N.; Lindemann, S.; Messina, M.; Naganoma, J.; Shagin, P.; Pienaar, J.; Garcia, D.R.; Reichard, S.; Lavina, L.S.; Stein, A.; Wang, H.; Trinchero, G.; Wei, Y.

    2017-01-01

    The XENON1T experiment at the Laboratori Nazionali del Gran Sasso (LNGS) is the first WIMP dark matter detector operating with a liquid xenon target mass above the ton-scale. Out of its 3.2 t liquid xenon inventory, 2.0 t constitute the active target of the dual-phase time projection chamber. The scintillation and ionization signals from particle interactions are detected with low-background photomultipliers. This article describes the XENON1T instrument and its subsystems as well as strategies to achieve an unprecedented low background level. First results on the detector response and the performance of the subsystems are also presented. (orig.)

  16. Xenon adsorption on geological media and implications for radionuclide signatures.

    Science.gov (United States)

    Paul, M J; Biegalski, S R; Haas, D A; Jiang, H; Daigle, H; Lowrey, J D

    2018-07-01

    The detection of radioactive noble gases is a primary technology for verifying compliance with the pending Comprehensive Nuclear-Test-Ban Treaty. A fundamental challenge in applying this technology for detecting underground nuclear explosions is estimating the timing and magnitude of the radionuclide signatures. While the primary mechanism for transport is advective transport, either through barometric pumping or thermally driven advection, diffusive transport in the surrounding matrix also plays a secondary role. From the study of primordial noble gas signatures, it is known that xenon has a strong physical adsorption affinity in shale formations. Given the unselective nature of physical adsorption, isotherm measurements reported here show that non-trivial amounts of xenon adsorb on a variety of media, in addition to shale. A dual-porosity model is then discussed demonstrating that sorption amplifies the diffusive uptake of an adsorbing matrix from a fracture. This effect may reduce the radioxenon signature down to approximately one-tenth, similar to primordial xenon isotopic signatures. Copyright © 2018 Elsevier Ltd. All rights reserved.

  17. Hyperpolarized nanodiamond with long spin-relaxation times

    Science.gov (United States)

    Rej, Ewa; Gaebel, Torsten; Boele, Thomas; Waddington, David E. J.; Reilly, David J.

    2015-10-01

    The use of hyperpolarized agents in magnetic resonance, such as 13C-labelled compounds, enables powerful new imaging and detection modalities that stem from a 10,000-fold boost in signal. A major challenge for the future of the hyperpolarization technique is the inherently short spin-relaxation times, typically nanodiamond can be hyperpolarized at cryogenic and room temperature without the use of free radicals, and, owing to their solid-state environment, exhibit relaxation times exceeding 1 h. Combined with the already established applications of nanodiamonds in the life sciences as inexpensive fluorescent markers and non-cytotoxic substrates for gene and drug delivery, these results extend the theranostic capabilities of nanoscale diamonds into the domain of hyperpolarized magnetic resonance.

  18. 3D Hyperpolarized C-13 EPI with Calibrationless Parallel Imaging

    DEFF Research Database (Denmark)

    Gordon, Jeremy W.; Hansen, Rie Beck; Shin, Peter J.

    2018-01-01

    With the translation of metabolic MRI with hyperpolarized 13C agents into the clinic, imaging approaches will require large volumetric FOVs to support clinical applications. Parallel imaging techniques will be crucial to increasing volumetric scan coverage while minimizing RF requirements and tem...... strategies to accelerate and undersample hyperpolarized 13C data using 3D blipped EPI acquisitions and multichannel receive coils, and demonstrated its application in a human study of [1-13C]pyruvate metabolism....

  19. Xenon thermal behavior in sintered titanium nitride, foreseen inert matrix for GFR

    International Nuclear Information System (INIS)

    Bes, R.

    2010-11-01

    This work concerns the generation IV future nuclear reactors such as gas-cooled fast reactor (GFR) for which refractory materials as titanium nitride (TiN) are needed to surround fuel and act as a fission product diffusion barrier. This study is about Xe thermal behavior in sintered titanium nitride. Microstructure effects on Xe behavior have been studied. In this purpose, several syntheses have been performed using different sintering temperatures and initial powder compositions. Xenon species have been introduced into samples by ionic implantation. Then, samples were annealed in temperature range from 1300 C to 1600 C, these temperatures being the accidental awaited temperature. A transport of xenon towards sample surface has been observed. Transport rate seems to be slow down when increasing sintering temperature. The composition of initial powder and the crystallographic orientation of each considered grain also influence xenon thermal behavior. Xenon release has been correlated with material oxidation during annealing. Xenon bubbles were observed. Their size is proportional with xenon concentration and increases with annealing temperature. Several mechanisms which could explain Xe intragranular mobility in TiN are proposed. In addition with experiments, very low Xe solubility in TiN has been confirmed by ab initio calculations. So, bi-vacancies were found to be the most favoured Xe incorporation sites in this material. (author)

  20. Dark matter search with XENON1T

    NARCIS (Netherlands)

    Aalbers, J.

    2018-01-01

    Most matter in the universe consists of 'dark matter' unknown to particle physics. Deep underground detectors such as XENON1T attempt to detect rare collisions of dark matter with ordinary atoms. This thesis describes the first dark matter search of XENON1T, how dark matter signals would appear in

  1. Sensitivity of gaseous xenon ionisation chambers (1961)

    International Nuclear Information System (INIS)

    Schuhl, C.

    1960-01-01

    It seems advantageous to fill an ionization chamber with xenon gas when this chamber is used for measuring a low intensity and high energy electron or positron beam, or monitoring a gamma beam. In the study of 5 to 50 MeV electrons, xenon allows for the ionization chamber yield, an improvement of a factor 4,5. (author) [fr

  2. Xenon lighting adjusted to plant requirements

    Energy Technology Data Exchange (ETDEWEB)

    Koefferlein, M.; Doehring, T.; Payer, H.D.; Seidlitz, H.K. [GSF-Forschungszentrum fuer Umwelt und Gesundheit, Oberschleissheim (Germany)

    1994-12-31

    The high luminous flux and spectral properties of xenon lamps would provide an ideal luminary for plant lighting if not excess IR radiation poses several problems for an application: the required filter systems reduce the irradiance at spectral regions of particular importance for plant development. Most of the economical drawbacks of xenon lamps are related to the difficult handling of that excess IR energy. Furthermore, the temporal variation of the xenon output depending on the oscillations of the applied AC voltage has to be considered for the plant development. However, xenon lamps outperform other lighting systems with respect to spectral stability, immediate response, and maximum luminance. Therefore, despite considerable competition by other lighting techniques, xenon lamps provide a very useful tool for special purposes. In plant lighting however, they seem to play a less important role as other lamp and lighting developments can meet these particular requirements at lower costs.

  3. Build up of Radioactive Krypton and Xenon Analysis System

    International Nuclear Information System (INIS)

    Lee, D. K.; Choi, C. S.; Chung, K. H.; Lee, W.; Cho, Y. H.; Lee, C. W.

    2008-03-01

    The objective of this project is to build up an analysis system to measure the activity of the atmospheric radioactive krypton and xenon in Korea. The work scopes of the project include the purchase and the installation of the analysis system to measure the activity of the radioactive krypton and xenon in air, and the establishment of the operation capability of the system through the training of the operator. The system consists of two air sampling systems, and one radioactivity analysis system, which incorporates the enrichment system, the gas chromatography to purify a mixture gas, and the gas proportional counter to count the activity of pure krypton and xenon gas. As planned originally, the establishment of the analysis system has been completed. At present, one air sampler is successfully being operated at a specific site of the South Korea to measure the background radioactivities of Kr-85 and Xe-133 in air. The other air sampler is being reserved at the KAERI in the Daejeon for a emergency like the second nuclear test of the North Korea. During the normal time, the reserved air sampler will be used to collect the air sample for the performance test of the analysis system and the cross analysis for the calibration of the system. The radioactivity analysis system has been installed at the KAERI, and is being used to measure the activity of Kr-85 and Xe-133 in the air sample from a domestic site

  4. The atmosphere of Mars - Detection of krypton and xenon

    Science.gov (United States)

    Owen, T.; Biemann, K.; Biller, J. E.; Lafleur, A. L.; Rushneck, D. R.; Howarth, D. W.

    1976-01-01

    Krypton and xenon have been discovered in the Martian atmosphere with the mass spectrometer on the second Viking lander. Krypton is more abundant than xenon. The relative abundances of the krypton isotopes appear normal, but the ratio of xenon-129 to xenon-132 is enhanced on Mars relative to the terrestrial value for this ratio. Some possible implications of these findings are discussed.

  5. Radon screening for XENON1T

    Energy Technology Data Exchange (ETDEWEB)

    Lindemann, Sebastian [Max-Planck-Institut fuer Kernphysik, Heidelberg (Germany)

    2015-07-01

    Radon with its isotope {sup 222}Rn is one of the dominant sources of internal background in liquid xenon detectors searching for low energetic rare events like WIMP-nucleon scattering. In my talk I briefly review the problem posed by {sup 222}Rn and motivate the screening strategy followed by XENON1T. I introduce the radon emanation technique making use of ultra low background proportional counters and present selected results obtained during the design and construction phases of XENON1T. Finally, I sketch advances in radon emanation assay techniques and give a short outlook on upcoming measurements.

  6. A novel approach to measure the electric dipole moment of 129Xenon

    Energy Technology Data Exchange (ETDEWEB)

    Kuchler, Florian; Feldmeier, Wolfhardt; Fierlinger, Peter; Taubenheim, Bernd [Excellence Cluster Universe, Technische Universitaet Muenchen, Garching (Germany)

    2012-07-01

    Permanent electric dipole moments (EDM) are promising systems to find new CP violation. The properties of the diamagnetic atom 129-Xe make it a particularly interesting candidate for an EDM search, as it enables new experimental strategies. Although the current experimental limit of d{sub Xe} < 4.0.10{sup -27} ecm is many orders of magnitude higher than the Standard Model (SM) prediction, theories beyond the SM usually require larger EDMs. Our experiment is based on microscopic hyper-polarized liquid xenon droplets, placed in a low-field NMR setup. Implementation of rotating electric fields enables a conceptually new EDM measurement technique, allowing thorough investigation of systematic effects. Still, a Ramsey-type spin precession experiment with static electric field can be realized at similar sensitivity within the same setup. Employing superconducting pick-up coils and highly sensitive LTc-SQUIDs, a large array of independent measurements can be performed simultaneously with different field configurations. With our novel approach we aim to be sensitive to an EDM of 129-Xe on the order of 10{sup -30} ecm. The talk gives an update on the current status of the xenon EDM experiment.

  7. Mechanism for transient migration of xenon in UO2

    International Nuclear Information System (INIS)

    Liu, X.-Y.; Uberuaga, B. P.; Andersson, D. A.; Stanek, C. R.; Sickafus, K. E.

    2011-01-01

    In this letter, we report recent work on atomistic modeling of diffusion migration events of the fission gas product xenon in UO 2 nuclear fuel. Under nonequilibrium conditions, Xe atoms can occupy the octahedral interstitial site, in contrast to the thermodynamically most stable uranium substitutional site. A transient migration mechanism involving Xe and two oxygen atoms is identified using basin constrained molecular dynamics employing a Buckingham type interatomic potential. This mechanism is then validated using density functional theory calculations using the nudged elastic band method. An overall reduction in the migration barrier of 1.6-2.7 eV is obtained compared to vacancy-mediated diffusion on the uranium sublattice.

  8. Determination of BEACON Coupling Coefficients using data from Xenon transient

    International Nuclear Information System (INIS)

    Bozic, M.; Kurincic, B.

    2007-01-01

    NEK uses BEACO TM code (BEACO TM - Westinghouse Best Estimate Analyzer for Core Operating Nuclear) for core monitoring, analysis and core behaviour prediction. Coupling Coefficients determine relationship between core response and excore instrumentation. Measured power distribution using incore moveable detectors during Xenon transient with sufficient power axial offset change is the most important data for further analysis. Classic methodology and BEACO TM Conservative methodology using established Coupling Coefficients are compared on NPP Krsko case. BEACON TM Conservative methodology with predefined Coupling Coefficients is used as a surveillance tool for verification of relationship between core and excore instrumentation during power operation. (author)

  9. 15N Hyperpolarization of Imidazole-15N2 for Magnetic Resonance pH Sensing via SABRE-SHEATH.

    Science.gov (United States)

    Shchepin, Roman V; Barskiy, Danila A; Coffey, Aaron M; Theis, Thomas; Shi, Fan; Warren, Warren S; Goodson, Boyd M; Chekmenev, Eduard Y

    2016-06-24

    15 N nuclear spins of imidazole- 15 N 2 were hyperpolarized using NMR signal amplification by reversible exchange in shield enables alignment transfer to heteronuclei (SABRE-SHEATH). A 15 N NMR signal enhancement of ∼2000-fold at 9.4 T is reported using parahydrogen gas (∼50% para-) and ∼0.1 M imidazole- 15 N 2 in methanol:aqueous buffer (∼1:1). Proton binding to a 15 N site of imidazole occurs at physiological pH (p K a ∼ 7.0), and the binding event changes the 15 N isotropic chemical shift by ∼30 ppm. These properties are ideal for in vivo pH sensing. Additionally, imidazoles have low toxicity and are readily incorporated into a wide range of biomolecules. 15 N-Imidazole SABRE-SHEATH hyperpolarization potentially enables pH sensing on scales ranging from peptide and protein molecules to living organisms.

  10. Xenon as an adjunct in computed tomography

    International Nuclear Information System (INIS)

    Kendall, B.E.; Radue, E.W.; Zilkha, E.; Loh, L.

    1979-01-01

    Nonradioactive xenon was used for enhancement in computed tomography in a series of 18 patients requiring general anesthesia. The method and results are described. The properties of xenon are radically different from those of intravenous iodides, and the enhancement patterns demonstrate different aspects of both normal and abnormal tissues. In our limited experience, it has been of value in those isodense and low attenuation lesions that have not enhanced after intravenous Conray. (orig.) 891 MG/orig. 892 MB [de

  11. Transportable Xenon Laboratory (TXL-1) Operations Manual

    Energy Technology Data Exchange (ETDEWEB)

    Thompson, Robert C.; Stewart, Timothy L.; Willett, Jesse A.; Woods, Vincent T.

    2011-03-07

    The Transportable Xenon Laboratory Operations Manual is a guide to set up and shut down TXL, a fully contained laboratory made up of instruments to identify and measure concentrations of the radioactive isotopes of xenon by taking air samples and analyzing them. The TXL is housed in a standard-sized shipping container. TXL can be shipped to and function in any country in the world.

  12. Ventilator-driven xenon ventilation studies

    International Nuclear Information System (INIS)

    Chilcoat, R.T.; Thomas, F.D.; Gerson, J.I.

    1984-01-01

    A modification of a common commercial Xe-133 ventilation device is described for mechanically assisted ventilation imaging. The patient's standard ventilator serves as the power source controlling the ventilatory rate and volume during the xenon study, but the gases in the two systems are not intermixed. This avoids contamination of the ventilator with radioactive xenon. Supplemental oxygen and positive end-expiratory pressure (PEEP) are provided if needed. The system can be converted quickly for conventional studies with spontaneous respiration

  13. Xenon-computed tomography of kidney transplants

    International Nuclear Information System (INIS)

    Mutze, S.; Reichmuth, B.; Suess, C.; Lippert, J.; Ewert, R.

    1994-01-01

    Xenon-CT is an established method for determining cerebral perfusion, while applications in other organs are rare. We evaluated the diagnostic potential of measuring the regional Renal Blood Flow (rRBF) in 10 patients with transplanted kidneys by xenon-CT. We found significant differences in the rRBF between the renal medulla and the cortex. There were no differences between normal renal transplants and transplants with chronic rejection. (orig.) [de

  14. Weird muonium diffusion in solid xenon

    International Nuclear Information System (INIS)

    Storchak, V.G.; Kirillov, B.F.; Pirogov, A.V.

    1992-09-01

    Muon and muonium spin rotation and relaxation parameters were studied in liquid and solid xenon. The small diamagnetic fraction (∼ 10%) observed in condensed xenon is believed to be Xeμ + . The muonium hyperfine frequency was measured for the first time in liquid Xe and was found to be in agreement with the vacuum value. A nonmonotonic temperature dependence of the muonium relaxation rate probably indicates that muonium diffusion in solid Xe is of quantum nature. 16 refs., 3 figs

  15. A comparison of quantitative methods for clinical imaging with hyperpolarized (13)C-pyruvate.

    Science.gov (United States)

    Daniels, Charlie J; McLean, Mary A; Schulte, Rolf F; Robb, Fraser J; Gill, Andrew B; McGlashan, Nicholas; Graves, Martin J; Schwaiger, Markus; Lomas, David J; Brindle, Kevin M; Gallagher, Ferdia A

    2016-04-01

    Dissolution dynamic nuclear polarization (DNP) enables the metabolism of hyperpolarized (13)C-labelled molecules, such as the conversion of [1-(13)C]pyruvate to [1-(13)C]lactate, to be dynamically and non-invasively imaged in tissue. Imaging of this exchange reaction in animal models has been shown to detect early treatment response and correlate with tumour grade. The first human DNP study has recently been completed, and, for widespread clinical translation, simple and reliable methods are necessary to accurately probe the reaction in patients. However, there is currently no consensus on the most appropriate method to quantify this exchange reaction. In this study, an in vitro system was used to compare several kinetic models, as well as simple model-free methods. Experiments were performed using a clinical hyperpolarizer, a human 3 T MR system, and spectroscopic imaging sequences. The quantitative methods were compared in vivo by using subcutaneous breast tumours in rats to examine the effect of pyruvate inflow. The two-way kinetic model was the most accurate method for characterizing the exchange reaction in vitro, and the incorporation of a Heaviside step inflow profile was best able to describe the in vivo data. The lactate time-to-peak and the lactate-to-pyruvate area under the curve ratio were simple model-free approaches that accurately represented the full reaction, with the time-to-peak method performing indistinguishably from the best kinetic model. Finally, extracting data from a single pixel was a robust and reliable surrogate of the whole region of interest. This work has identified appropriate quantitative methods for future work in the analysis of human hyperpolarized (13)C data. © 2016 The Authors. NMR in Biomedicine published by John Wiley & Sons Ltd.

  16. Assessing the transport rate of hyperpolarized pyruvate and lactate from the intra- to the extracellular space.

    Science.gov (United States)

    Reineri, Francesca; Daniele, Valeria; Cavallari, Eleonora; Aime, Silvio

    2016-08-01

    The use of [1-(13) C]pyruvate hyperpolarized by means of dynamic nuclear polarization provides a direct way to track the metabolic transformations of this metabolite in vivo and in cell cultures. The identification of the intra- and extracellular contributions to the (13) C NMR resonances is not straightforward. In order to obtain information about the rate of pyruvate and lactate transport through the cellular membrane, we set up a method that relies on the sudden 'quenching' of the extracellular metabolites' signal. The paramagnetic Gd-tetraazacyclododecane triacetic acid (Gd-DO3A) complex was used to dramatically decrease the longitudinal relaxation time constants of the (13) C-carboxylate resonances of both pyruvate and lactate. When Gd-DO3A was added to an MCF-7 cellular culture, which had previously received a dose of hyperpolarized [1-(13) C]pyruvate, the contributions of the extracellular pyruvate and lactate signals were deleted. From the analysis of the decay curves of the (13) C-carboxylate resonances of pyruvate and lactate it was possible to extract information about the exchange rate of the two metabolites across the cellular membrane. In particular, it was found that, in the reported experimental conditions, the lactate transport from the intra- to the extracellular space is not much lower than the rate of lactate formation. The method reported herein is non-destructive and it could be translated to in vivo studies. It opens a route for the use of hyperpolarized pyruvate to assess altered activity of carboxylate transporter proteins that may occur in pathological conditions. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  17. The behavior of xenon dynamic adsorption on granular activated carbon packed bed adsorber

    International Nuclear Information System (INIS)

    Chongyang Zhou; Shujuan Feng; Guoqing Zhou; Yuren Jin; Junfu Liang; Jingming Xu

    2011-01-01

    In order to retard radioxenon release into the atmosphere from nuclear power station or to sensitively monitor its concentration to ensure environmental and human safety, it is necessary to know the behavior of xenon dynamic adsorption on granular activated carbon pack bed adsorber. The quantities, including the dynamic adsorption coefficient (k d ), the amount of xenon adsorbed (q), the length of mass transfer zone (L MTZ ) and the length of the unused bed (LUB), used to describe the adsorption behavior, were sorted out and calculated. The factors, including xenon concentrations, pressures and temperatures, to affect these quantities were investigated. The results show that: (1) The values of k d and q decrease with increasing temperatures, but increase with increasing pressures, (2) The values of L MTZ and LUB increase with increasing temperatures or pressures, but are independent of concentrations. Knowledge of these quantities is very helpful for packed bed adsorber operation. (author)

  18. Direct hyperpolarization of micro- and nanodiamonds for bioimaging applications - Considerations on particle size, functionalization and polarization loss.

    Science.gov (United States)

    Kwiatkowski, Grzegorz; Jähnig, Fabian; Steinhauser, Jonas; Wespi, Patrick; Ernst, Matthias; Kozerke, Sebastian

    2018-01-01

    Due to the inherently long relaxation time of 13 C spins in diamond, the nuclear polarization enhancement obtained with dynamic nuclear polarization can be preserved for a time on the order of about one hour, opening up an opportunity to use diamonds as a new class of long-lived contrast agents. The present communication explores the feasibility of using 13 C spins in directly hyperpolarized diamonds for MR imaging including considerations for potential in vivo applications. Copyright © 2017 Elsevier Inc. All rights reserved.

  19. Hyperpolarized 13C MR Markers of Renal Tumor Aggressiveness

    Science.gov (United States)

    2015-12-01

    production in the presence of oxygen (11, 12). Increased glycolysis facilitates the uptake and incorporation of nutrients and biomass needed for cell... shell coil; (d) Hyperpolarized lactate images overlaid on T2 weighted anatomical images, clearly depicting the tumor voxels (Figure 5). As shown in

  20. Hyperpolarized C-13 MRS Cardiac Metabolism Studies in Pigs

    DEFF Research Database (Denmark)

    Giovannetti, G.; Hartwig, V.; Frijia, F.

    2012-01-01

    Cardiac metabolism assessment with hyperpolarized 13C magnetic resonance spectroscopy in pig models requires the design of dedicated coils capable of providing large field of view with high signal-to-noise ratio (SNR) data. This work presents a comparison between a commercial 13C quadrature...

  1. Fluconazole treatment hyperpolarizes the plasma membrane of Candida cells

    Czech Academy of Sciences Publication Activity Database

    Elicharová, Hana; Sychrová, Hana

    2013-01-01

    Roč. 51, č. 8 (2013), s. 785-798 ISSN 1369-3786 R&D Projects: GA ČR GAP302/12/1151 Institutional research plan: CEZ:AV0Z50110509 Institutional support: RVO:67985823 Keywords : drug resistance * fluconazol * yeast * hyperpolarization Subject RIV: EE - Microbiology, Virology Impact factor: 2.261, year: 2013

  2. Hyperpolarized 2-oxoglutarate as metabolic agent in mr

    DEFF Research Database (Denmark)

    2015-01-01

    Hyperpolarized 1-13C-2-oxoglutarate as contrast agent in13C Magnetic Resonance diagnostic technique (13C-MRI) for use in the diagnosis of cancer. In particular, upon administration of said 1-13C-2-oxoglutarate, signals of 1-13C-glutamate are detected. More in particular, different MR signals from13...

  3. Ionic channels and membrane hyperpolarization in human macrophages

    NARCIS (Netherlands)

    Ince, C.; van Duijn, B.; Ypey, D. L.; van Bavel, E.; Weidema, F.; Leijh, P. C.

    1987-01-01

    Microelectrode impalement of human macrophages evokes a transient hyperpolarizing response (HR) of the membrane potential. This HR was found to be dependent on the extracellular concentration of K+ but not on that of Na+ or Cl-. It was not influenced by low temperature (12 degrees C) or by 0.2 mM

  4. Solubility of xenon in liquid sodium

    International Nuclear Information System (INIS)

    Veleckis, E.; Cafasso, F.A.; Feder, H.M.

    1976-01-01

    The solubility of xenon in liquid sodium was measured as a function of pressure (2-8 atm) and temperature (350-600 0 C). Henry's law was obeyed with the value of the Henry's law constant, K/sub H/ = N/sub Xe//P, ranging from 1.38 x 10 -10 atm -1 at 350C, to 1.59 x 10 -8 atm -1 at 600 0 C where N/sub Xe/ and P are the atom fraction and the partial pressure of xenon, respectively. The temperature dependence of solubility may be represented by log 10 lambda = (0.663 +- 0.01) - (4500 +- 73) T -1 , where lambda is the Ostwald coefficient (the volume of xenon dissolved per unit volume of sodium at the temperature of the experiment). The heat of solution of xenon in sodium was 20.6 +- 0.7 kcal/mole, where the standard state of xenon is defined as that of 1 mole of an ideal gas, confined to a volume equal to the molar volume of sodium

  5. Cosmogenic activation of xenon and copper

    Energy Technology Data Exchange (ETDEWEB)

    Baudis, Laura; Kish, Alexander; Piastra, Francesco [University of Zuerich, Department of Physics, Zuerich (Switzerland); Schumann, Marc [University of Bern, Albert Einstein Center for Fundamental Physics, Bern (Switzerland)

    2015-10-15

    Rare event search experiments using liquid xenon as target and detection medium require ultra-low background levels to fully exploit their physics potential. Cosmic ray induced activation of the detector components and, even more importantly, of the xenon itself during production, transportation and storage at the Earth's surface, might result in the production of radioactive isotopes with long half-lives, with a possible impact on the expected background. We present the first dedicated study on the cosmogenic activation of xenon after 345 days of exposure to cosmic rays at the Jungfraujoch research station at 3470 m above sea level, complemented by a study of copper which has been activated simultaneously. We have directly observed the production of {sup 7}Be, {sup 101}Rh, {sup 125}Sb, {sup 126}I and {sup 127}Xe in xenon, out of which only {sup 125}Sb could potentially lead to background for a multi-ton scale dark matter search. The production rates for five out of eight studied radioactive isotopes in copper are in agreement with the only existing dedicated activation measurement, while we observe lower rates for the remaining ones. The specific saturation activities for both samples are also compared to predictions obtained with commonly used software packages, where we observe some underpredictions, especially for xenon activation. (orig.)

  6. Properties of excited xenon atoms in a plasma display panel

    International Nuclear Information System (INIS)

    Uhm, Han S.; Hong, Byoung H.; Oh, Phil Y.; Choi, Eun H.

    2009-01-01

    The luminance efficiency of a plasma display panel is directly related to the vacuum ultraviolet (VUV) light that is emitted from excited xenon (Xe) atoms and molecules. It is therefore necessary to investigate the properties of excited xenon atoms. This study presents experimental data associated with the behavior of excited xenon atoms in a PDP discharge cell and compares the data with the theoretical results obtained using an analytical model. The properties of excited xenon atoms in the discharge cells of a plasma display panel are investigated by measuring the excited atom density through the use of laser absorption spectroscopy. The density of the excited xenon atoms increases from zero, reaches its peak, and decreases with time in the discharge cells. The profile of the excited xenon atoms is also studied in terms of the xenon mole fraction. The typical density of the excited xenon atoms in the metastable state is on the order of 10 13 atoms per cubic cm.

  7. Rapid assessment of pulmonary gas transport with hyperpolarized 129Xe MRI using a 3D radial double golden-means acquisition with variable flip angles.

    Science.gov (United States)

    Ruppert, Kai; Amzajerdian, Faraz; Hamedani, Hooman; Xin, Yi; Loza, Luis; Achekzai, Tahmina; Duncan, Ian F; Profka, Harrilla; Siddiqui, Sarmad; Pourfathi, Mehrdad; Cereda, Maurizio F; Kadlecek, Stephen; Rizi, Rahim R

    2018-04-22

    To demonstrate the feasibility of using a 3D radial double golden-means acquisition with variable flip angles to monitor pulmonary gas transport in a single breath hold with hyperpolarized xenon-129 MRI. Hyperpolarized xenon-129 MRI scans with interleaved gas-phase and dissolved-phase excitations were performed using a 3D radial double golden-means acquisition in mechanically ventilated rabbits. The flip angle was either held fixed at 15 ° or 5 °, or it was varied linearly in ascending or descending order between 5 ° and 15 ° over a sampling interval of 1000 spokes. Dissolved-phase and gas-phase images were reconstructed at high resolution (32 × 32 × 32 matrix size) using all 1000 spokes, or at low resolution (22 × 22 × 22 matrix size) using 400 spokes at a time in a sliding-window fashion. Based on these sliding-window images, relative change maps were obtained using the highest mean flip angle as the reference, and aggregated pixel-based changes were tracked. Although the signal intensities in the dissolve-phase maps were mostly constant in the fixed flip-angle acquisitions, they varied significantly as a function of average flip angle in the variable flip-angle acquisitions. The latter trend reflects the underlying changes in observed dissolve-phase magnetization distribution due to pulmonary gas uptake and transport. 3D radial double golden-means acquisitions with variable flip angles provide a robust means for rapidly assessing lung function during a single breath hold, thereby constituting a particularly valuable tool for imaging uncooperative or pediatric patient populations. © 2018 International Society for Magnetic Resonance in Medicine.

  8. Comparison of air space measurement imaged by CT, small-animal CT, and hyperpolarized Xe MRI

    Science.gov (United States)

    Madani, Aniseh; White, Steven; Santyr, Giles; Cunningham, Ian

    2005-04-01

    Lung disease is the third leading cause of death in the western world. Lung air volume measurements are thought to be early indicators of lung disease and markers in pharmaceutical research. The purpose of this work is to develop a lung phantom for assessing and comparing the quantitative accuracy of hyperpolarized xenon 129 magnetic resonance imaging (HP 129Xe MRI), conventional computed tomography (HRCT), and highresolution small-animal CT (μCT) in measuring lung gas volumes. We developed a lung phantom consisting of solid cellulose acetate spheres (1, 2, 3, 4 and 5 mm diameter) uniformly packed in circulated air or HP 129Xe gas. Air volume is estimated based on simple thresholding algorithm. Truth is calculated from the sphere diameters and validated using μCT. While this phantom is not anthropomorphic, it enables us to directly measure air space volume and compare these imaging methods as a function of sphere diameter for the first time. HP 129Xe MRI requires partial volume analysis to distinguish regions with and without 129Xe gas and results are within %5 of truth but settling of the heavy 129Xe gas complicates this analysis. Conventional CT demonstrated partial-volume artifacts for the 1mm spheres. μCT gives the most accurate air-volume results. Conventional CT and HP 129Xe MRI give similar results although non-uniform densities of 129Xe require more sophisticated algorithms than simple thresholding. The threshold required to give the true air volume in both HRCT and μCT, varies with sphere diameters calling into question the validity of thresholding method.

  9. Conception and synthesis of new molecular cages for xenon MRI applications

    International Nuclear Information System (INIS)

    Delacour, L.

    2011-01-01

    Non-invasive proton magnetic resonance imaging ( 1 H MRI) is a powerful clinical tool for the detection of numerous diseases. Although MRI contrast agents are often used to improve diagnostic specificity, this technique has limited applications in molecular imaging because of its inherently low sensitivity when compared to nuclear medicine or fluorescence imaging. Laser-polarized 129 Xe NMR spectroscopy is a promising tool to circumvent sensitivity limitations. Indeed, optical pumping increases the nuclear spin polarization of xenon by several orders of magnitude (10 4 to 10 5 ), thus small amounts of gas dissolved in biological tissues (blood, lungs...) can be rapidly detected with an excellent signal-to-noise ratio. In addition, the high polarizability of the xenon electron cloud, which induces a very high sensitivity to its environment, makes this nucleus very attractive for molecular imaging. Detection of biomolecules can be achieved by biosensors, which encapsulate xenon atoms in molecular cages that have been functionalized to bind the desired biological target. Cage molecules such as cryptophanes have high affinity for xenon and thus appear as ideal candidates for its encapsulation. During this PhD thesis we worked on the synthesis and the functionalization of new cryptophanes. (author) [fr

  10. Spatial xenon oscillation control with expert systems

    International Nuclear Information System (INIS)

    Alten, S.; Danofsky, R.A.

    1993-01-01

    Spatial power oscillations were attributed to the xenon transients in a reactor core in 1958 by Randall and St. John. These transients are usually initiated by a local reactivity insertion and lead to divergent axial flux oscillations in the core at constant power. Several heuristic manual control strategies and automatic control methods were developed to damp the xenon oscillations at constant power operations. However, after the load-follow operation of the reactors became a necessity of life, a need for better control strategies arose. Even though various advanced control strategies were applied to solve the xenon oscillation control problem for the load-follow operation, the complexity of the system created difficulties in modeling. The strong nonlinearity of the problem requires highly sophisticated analytical approaches that are quite inept for numerical solutions. On the other hand, the complexity of a system and heuristic nature of the solutions are the basic reasons for using artificial intelligence techniques such as expert systems

  11. Effects of pyruvate dose on in vivo metabolism and quantification of hyperpolarized 13C spectra

    DEFF Research Database (Denmark)

    Janich, M. A.; Menzel, M. I.; Wiesinger, F.

    2012-01-01

    Real‐time in vivo measurements of metabolites are performed by signal enhancement of [1‐13C]pyruvate using dynamic nuclear polarization, rapid dissolution and intravenous injection, acquisition of free induction decay signals and subsequent quantification of spectra. The commonly injected dose...... uptake and metabolic conversion. The goal of this study was to examine the effects of a [1‐13C]pyruvate bolus on metabolic conversion in vivo. Spectra were quantified by three different methods: frequency‐domain fitting with LCModel, time‐domain fitting with AMARES and simple linear least‐squares fitting...... in the time domain. Since the simple linear least‐squares approach showed bleeding artifacts and LCModel produced noisier time signals. AMARES performed best in the quantification of in vivo hyperpolarized pyruvate spectra. We examined pyruvate doses of 0.1–0.4 mmol/kg (body mass) in male Wistar rats...

  12. Hyperpolarized krypton-83 as a contrast agent for magnetic resonance imaging.

    Science.gov (United States)

    Pavlovskaya, Galina E; Cleveland, Zackary I; Stupic, Karl F; Basaraba, Randall J; Meersmann, Thomas

    2005-12-20

    For the first time, magnetic resonance imaging (MRI) with hyperpolarized (hp) krypton-83 (83Kr) has become available. The relaxation of the nuclear spin of 83Kr atoms (I = 9/2) is driven by quadrupolar interactions during brief adsorption periods on surrounding material interfaces. Experiments in model systems reveal that the longitudinal relaxation of hp 83Kr gas strongly depends on the chemical composition of the materials. The relaxation-weighted contrast in hp 83Kr MRI allows for the distinction between hydrophobic and hydrophilic surfaces. The feasibility of hp 83Kr MRI of airways is tested in canine lung tissue by using krypton gas with natural abundance isotopic distribution. Additionally, the influence of magnetic field strength and the presence of a breathable concentration of molecular oxygen on longitudinal relaxation are investigated.

  13. Magnetic Resonance Angiography in the Pig using Hyperpolarized Water

    DEFF Research Database (Denmark)

    Lipsø, Hans Kasper Wigh; Bowen, Sean; Laustsen, Christoffer

    , the magnetization achievable with hyperpolarized water is superior to other nuclei. Methods A 1 mL sample of 50% water and 50% glycerol with 30 mM TEMPO is polarized in a Spinlab (GE Healthcare) at 5 T, 0.9 K, 139.9 GHz for an hour. The sample is rapidly dissolved in 16 mL deoxygenized dissolution medium (DM......Introduction Magnetic Resonance Angiography (MRA) is an important tool in diagnostics of medical conditions such as emboli, stenosis and aneurysms. Sub-millimetre resolution can be obtained with proton imaging, and further optimization can be obtained with Gd-based blood pool agents1. However......, the acquisition time is several minutes, and conventional MRA methods thus fail to image within a single respiration or heartbeat and therefore suffers from motion artefacts. We demonstrate that hyperpolarized (HP) water can be used as an imaging agent to provide subsecond angiographies in pigs. Previous work...

  14. Continuous hyperpolarization with parahydrogen in a membrane reactor

    Science.gov (United States)

    Lehmkuhl, Sören; Wiese, Martin; Schubert, Lukas; Held, Mathias; Küppers, Markus; Wessling, Matthias; Blümich, Bernhard

    2018-06-01

    Hyperpolarization methods entail a high potential to boost the sensitivity of NMR. Even though the "Signal Amplification by Reversible Exchange" (SABRE) approach uses para-enriched hydrogen, p-H2, to repeatedly achieve high polarization levels on target molecules without altering their chemical structure, such studies are often limited to batch experiments in NMR tubes. Alternatively, this work introduces a continuous flow setup including a membrane reactor for the p-H2, supply and consecutive detection in a 1 T NMR spectrometer. Two SABRE substrates pyridine and nicotinamide were hyperpolarized, and more than 1000-fold signal enhancement was found. Our strategy combines low-field NMR spectrometry and a membrane flow reactor. This enables precise control of the experimental conditions such as liquid and gas pressures, and volume flow for ensuring repeatable maximum polarization.

  15. Nuclear magnetic resonance gyroscope

    International Nuclear Information System (INIS)

    Grover, B.C.

    1984-01-01

    A nuclear magnetic resonance gyro using two nuclear magnetic resonance gases, preferably xenon 129 and xenon 131, together with two alkaline metal vapors, preferably rubidium, potassium or cesium, one of the two alkaline metal vapors being pumped by light which has the wavelength of that alkaline metal vapor, and the other alkaline vapor being illuminated by light which has the wavelength of that other alkaline vapor

  16. Feasibility, tolerability and safety of pediatric hyperpolarized "1"2"9Xe magnetic resonance imaging in healthy volunteers and children with cystic fibrosis

    International Nuclear Information System (INIS)

    Walkup, Laura L.; Watters, Erin; Ruppert, Kai; Thomen, Robert P.; Woods, Jason C.; Akinyi, Teckla G.; Cleveland, Zackary I.; Clancy, John P.

    2016-01-01

    Hyperpolarized "1"2"9Xe is a promising contrast agent for MRI of pediatric lung function, but its safety and tolerability in children have not been rigorously assessed. To assess the feasibility, safety and tolerability of hyperpolarized "1"2"9Xe gas as an inhaled contrast agent for pediatric pulmonary MRI in healthy control subjects and in children with cystic fibrosis. Seventeen healthy control subjects (ages 6-15 years, 11 boys) and 11 children with cystic fibrosis (ages 8-16 years, 4 boys) underwent "1"2"9Xe MRI, receiving up to three doses of "1"2"9Xe gas prepared by either a commercially available or a homebuilt "1"2"9Xe polarizer. Subject heart rate and SpO_2 were monitored for 2 min post inhalation and compared to resting baseline values. Adverse events were reported via follow-up phone call at days 1 and 30 (range ±7 days) post-MRI. All children tolerated multiple doses of "1"2"9Xe, and no children withdrew from the study. Relative to baseline, most children who received a full dose of gas for imaging (10 of 12 controls and 8 of 11 children with cystic fibrosis) experienced a nadir in SpO_2 (mean -6.0 ± standard deviation 7.2%, P≤0.001); however within 2 min post inhalation SpO_2 values showed no significant difference from baseline (P=0.11). There was a slight elevation in heart rate (mean +6.6 ± 13.9 beats per minute [bpm], P=0.021), which returned from baseline within 2 min post inhalation (P=0.35). Brief side effects related to the anesthetic properties of xenon were mild and quickly resolved without intervention. No serious or severe adverse events were observed; in total, four minor adverse events (14.3%) were reported following "1"2"9Xe MRI, but all were deemed unrelated to the study. The feasibility, safety and tolerability of "1"2"9Xe MRI has been assessed in a small group of children as young as 6 years. SpO_2 changes were consistent with the expected physiological effects of a short anoxic breath-hold, and other mild side effects were

  17. Feasibility, tolerability and safety of pediatric hyperpolarized {sup 129}Xe magnetic resonance imaging in healthy volunteers and children with cystic fibrosis

    Energy Technology Data Exchange (ETDEWEB)

    Walkup, Laura L.; Watters, Erin; Ruppert, Kai [Cincinnati Children' s Hospital Medical Center, Center for Pulmonary Imaging Research, Division of Pulmonary Medicine and Department of Radiology, Cincinnati, OH (United States); Thomen, Robert P.; Woods, Jason C. [Cincinnati Children' s Hospital Medical Center, Center for Pulmonary Imaging Research, Division of Pulmonary Medicine and Department of Radiology, Cincinnati, OH (United States); Washington University in St. Louis, Department of Physics, St. Louis, MO (United States); Akinyi, Teckla G.; Cleveland, Zackary I. [Cincinnati Children' s Hospital Medical Center, Center for Pulmonary Imaging Research, Division of Pulmonary Medicine and Department of Radiology, Cincinnati, OH (United States); University of Cincinnati, Biomedical Engineering Program, Cincinnati, OH (United States); Clancy, John P. [Cincinnati Children' s Hospital Medical Center, Division of Pulmonary Medicine, Cincinnati, OH (United States)

    2016-11-15

    Hyperpolarized {sup 129}Xe is a promising contrast agent for MRI of pediatric lung function, but its safety and tolerability in children have not been rigorously assessed. To assess the feasibility, safety and tolerability of hyperpolarized {sup 129}Xe gas as an inhaled contrast agent for pediatric pulmonary MRI in healthy control subjects and in children with cystic fibrosis. Seventeen healthy control subjects (ages 6-15 years, 11 boys) and 11 children with cystic fibrosis (ages 8-16 years, 4 boys) underwent {sup 129}Xe MRI, receiving up to three doses of {sup 129}Xe gas prepared by either a commercially available or a homebuilt {sup 129}Xe polarizer. Subject heart rate and SpO{sub 2} were monitored for 2 min post inhalation and compared to resting baseline values. Adverse events were reported via follow-up phone call at days 1 and 30 (range ±7 days) post-MRI. All children tolerated multiple doses of {sup 129}Xe, and no children withdrew from the study. Relative to baseline, most children who received a full dose of gas for imaging (10 of 12 controls and 8 of 11 children with cystic fibrosis) experienced a nadir in SpO{sub 2} (mean -6.0 ± standard deviation 7.2%, P≤0.001); however within 2 min post inhalation SpO{sub 2} values showed no significant difference from baseline (P=0.11). There was a slight elevation in heart rate (mean +6.6 ± 13.9 beats per minute [bpm], P=0.021), which returned from baseline within 2 min post inhalation (P=0.35). Brief side effects related to the anesthetic properties of xenon were mild and quickly resolved without intervention. No serious or severe adverse events were observed; in total, four minor adverse events (14.3%) were reported following {sup 129}Xe MRI, but all were deemed unrelated to the study. The feasibility, safety and tolerability of {sup 129}Xe MRI has been assessed in a small group of children as young as 6 years. SpO{sub 2} changes were consistent with the expected physiological effects of a short anoxic breath

  18. SPALAX new generation: New process design for a more efficient xenon production system for the CTBT noble gas network.

    Science.gov (United States)

    Topin, Sylvain; Greau, Claire; Deliere, Ludovic; Hovesepian, Alexandre; Taffary, Thomas; Le Petit, Gilbert; Douysset, Guilhem; Moulin, Christophe

    2015-11-01

    The SPALAX (Système de Prélèvement Automatique en Ligne avec l'Analyse du Xénon) is one of the systems used in the International Monitoring System of the Comprehensive Nuclear Test Ban Treaty (CTBT) to detect radioactive xenon releases following a nuclear explosion. Approximately 10 years after the industrialization of the first system, the CEA has developed the SPALAX New Generation, SPALAX-NG, with the aim of increasing the global sensitivity and reducing the overall size of the system. A major breakthrough has been obtained by improving the sampling stage and the purification/concentration stage. The sampling stage evolution consists of increasing the sampling capacity and improving the gas treatment efficiency across new permeation membranes, leading to an increase in the xenon production capacity by a factor of 2-3. The purification/concentration stage evolution consists of using a new adsorbent Ag@ZSM-5 (or Ag-PZ2-25) with a much larger xenon retention capacity than activated charcoal, enabling a significant reduction in the overall size of this stage. The energy consumption of the system is similar to that of the current SPALAX system. The SPALAX-NG process is able to produce samples of almost 7 cm(3) of xenon every 12 h, making it the most productive xenon process among the IMS systems. Copyright © 2015 Elsevier Ltd. All rights reserved.

  19. Experimental development of a liquid xenon Compton telescope for functional medical imaging

    International Nuclear Information System (INIS)

    Oger, Tugdual

    2012-01-01

    3γ imaging is a new nuclear medical imaging technique which has been suggested by Subatech laboratory. This technique involves locating three-dimensional position of the decay of an innovative radioisotope (β + ,γ) emitter, the 44 Sc. The principle consist in the detection of two photons of 511 keV gamma rays from the decay of the positron, provided by a PET ring detector, associated to the detection of the third photon by a Liquid xenon Compton telescope. The energy deposited in the interaction between the photon and xenon and its position are identified by measuring the ionization signal with a Micromegas chamber (Micro-Mesh Gaseous Structure), while the trigger and time measurement of the interaction are provided by the detection of the scintillation signal. The principle of the TPC is thus used to Compton imaging. In order to demonstrate experimentally the feasibility of imaging 3γ, a small prototype, XEMIS (Xenon Medical Imaging System) was developed. This thesis is an important step towards the proof of feasibility. In this work are exposed the characterization of the detector response for a beam of 511 keV gamma rays and the analysis of data derived from it. The measurement of energy and time resolutions will be presented, as well as the purity of the liquid xenon. (author) [fr

  20. Analysis of reactivity worth for xenon poisoning during restart-up of reactor in iodine pit

    International Nuclear Information System (INIS)

    Li Xaofeng; Chen Wenzhen; Zhu Qian; Xu Guojun

    2009-01-01

    The reactivity worth of xenon poisoning and the densities of 135 I and 135 Xe were derived when the reactor was restarted up in iodine pit. Through the expressions obtained we can find the physics characteristics of reactor restarted up in iodine pit comprehensively and essentially. The results were analyzed and discussed. The reactor power before shutdown, the start-up power, the position where the reactor starts up in iodine pit, and so on, all have effect on the reactivity worth of xenon poisoning, and the different conditions can lead to totally different physics characteristics. In addition, the time when the reactor starts up in iodine pit is a very important factor for nuclear reactors safety. The conclusions are very important to the maneuverability and operation safety of ship nuclear reactors. (authors)

  1. A new approach for treatment of xenon problem

    International Nuclear Information System (INIS)

    Mihailescu, Nicolae

    1999-01-01

    It is known that the fission product xenon 135, with a half life of 9.17 hours, has a very large absorption cross section for thermal neutrons. A small fraction of this nuclear species is formed directly in fission, but the major part results from the decay of iodine 135 with a half life of 6.59 hours. In this paper we shall present the 'fundamental' theory of an 'adiabatic' approach which appears to be promising both in cutting down computational time and in giving additional physical insight into the combined spatial-temporal variations. An adiabatic motivation is implicit in early work on reactor kinetics in which the reactor flux is separated into a product of a time dependent function and a function of all the other relevant variables, including the time; if the latter factor is slowly varying in time the approach is 'adiabatic'. (author)

  2. A hyperpolarized equilibrium for magnetic resonance.

    Science.gov (United States)

    Hövener, Jan-Bernd; Schwaderlapp, Niels; Lickert, Thomas; Duckett, Simon B; Mewis, Ryan E; Highton, Louise A R; Kenny, Stephen M; Green, Gary G R; Leibfritz, Dieter; Korvink, Jan G; Hennig, Jürgen; von Elverfeldt, Dominik

    2013-01-01

    Nuclear magnetic resonance spectroscopy and imaging (MRI) play an indispensable role in science and healthcare but use only a tiny fraction of their potential. No more than ≈10 p.p.m. of all ¹H nuclei are effectively detected in a 3-Tesla clinical MRI system. Thus, a vast array of new applications lays dormant, awaiting improved sensitivity. Here we demonstrate the continuous polarization of small molecules in solution to a level that cannot be achieved in a viable magnet. The magnetization does not decay and is effectively reinitialized within seconds after being measured. This effect depends on the long-lived, entangled spin-order of parahydrogen and an exchange reaction in a low magnetic field of 10⁻³ Tesla. We demonstrate the potential of this method by fast MRI and envision the catalysis of new applications such as cancer screening or indeed low-field MRI for routine use and remote application.

  3. Results from the 1 tonne*year Dark Matter Search with XENON1T

    CERN Multimedia

    CERN. Geneva

    2018-01-01

    Weakly Interacting Massive Particles (WIMPs) are an excellent candidate for the mysterious Dark Matter in the Universe. The XENON1T experiment at LNGS is the world’s largest and most sensitive experiment for the direct detection of WIMPs via nuclear recoils. Details of the experiment and of the achieved unprecedented low background conditions will be covered and new results from a record exposure of 1 tonne x year will be presented for the first time.

  4. An automated multidimensional preparative gas chromatographic system for isolation and enrichment of trace amounts of xenon from ambient air.

    Science.gov (United States)

    Larson, Tuula; Östman, Conny; Colmsjö, Anders

    2011-04-01

    The monitoring of radioactive xenon isotopes is one of the principal methods for the detection of nuclear explosions in order to identify clandestine nuclear testing. In this work, a miniaturized, multiple-oven, six-column, preparative gas chromatograph was constructed in order to isolate trace quantities of radioactive xenon isotopes from ambient air, utilizing nitrogen as the carrier gas. The multidimensional chromatograph comprised preparative stainless steel columns packed with molecular sieves, activated carbon, and synthetic carbon adsorbents (e.g., Anasorb®-747 and Carbosphere®). A combination of purification techniques--ambient adsorption, thermal desorption, back-flushing, thermal focusing, and heart cutting--was selectively optimized to produce a well-defined xenon peak that facilitated reproducible heart cutting and accurate quantification. The chromatographic purification of a sample requires approximately 4 h and provides complete separation of xenon from potentially interfering components (such as water vapor, methane, carbon dioxide, and radon) with recovery and accuracy close to 100%. The preparative enrichment process isolates and concentrates a highly purified xenon gas fraction that is suitable for subsequent ultra-low-level γ-, ß/γ-spectroscopic or high-resolution mass spectrometric measurement (e.g., to monitor the gaseous fission products of nuclear explosions at remote locations). The Xenon Processing Unit is a free-standing, relatively lightweight, and transportable system that can be interfaced to a variety of sampling and detection systems. It has a relatively inexpensive, rugged, and compact modular (19-inch rack) design that provides easy access to all parts for maintenance and has a low power requirement.

  5. Reaction monitoring using hyperpolarized NMR with scaling of heteronuclear couplings by optimal tracking

    Science.gov (United States)

    Zhang, Guannan; Schilling, Franz; Glaser, Steffen J.; Hilty, Christian

    2016-11-01

    Off-resonance decoupling using the method of Scaling of Heteronuclear Couplings by Optimal Tracking (SHOT) enables determination of heteronuclear correlations of chemical shifts in single scan NMR spectra. Through modulation of J-coupling evolution by shaped radio frequency pulses, off resonance decoupling using SHOT pulses causes a user-defined dependence of the observed J-splitting, such as the splitting of 13C peaks, on the chemical shift offset of coupled nuclei, such as 1H. Because a decoupling experiment requires only a single scan, this method is suitable for characterizing on-going chemical reactions using hyperpolarization by dissolution dynamic nuclear polarization (D-DNP). We demonstrate the calculation of [13C, 1H] chemical shift correlations of the carbanionic active sites from hyperpolarized styrene polymerized using sodium naphthalene as an initiator. While off resonance decoupling by SHOT pulses does not enhance the resolution in the same way as a 2D NMR spectrum would, the ability to obtain the correlations in single scans makes this method ideal for determination of chemical shifts in on-going reactions on the second time scale. In addition, we present a novel SHOT pulse that allows to scale J-splittings 50% larger than the respective J-coupling constant. This feature can be used to enhance the resolution of the indirectly detected chemical shift and reduce peak overlap, as demonstrated in a model reaction between p-anisaldehyde and isobutylamine. For both pulses, the accuracy is evaluated under changing signal-to-noise ratios (SNR) of the peaks from reactants and reaction products, with an overall standard deviation of chemical shift differences compared to reference spectra of 0.02 ppm when measured on a 400 MHz NMR spectrometer. Notably, the appearance of decoupling side-bands, which scale with peak intensity, appears to be of secondary importance.

  6. Design of Solid Form Xenon-124 Target for Producing I-123 Radioisotope Using Computer Simulation Techniques

    International Nuclear Information System (INIS)

    Kamali Moghaddam, K.; Sadeghi, M.; Kakavand, T.; Shokri Bonab, S.

    2006-01-01

    Recently in Cyclotron and Nuclear Medicine Department of NRCAM, at Atomic Energy organization of Iran (AEOI), a system for producing 1-123 via Xe-124 gas target technology, has been constructed and installed. One of the major problems in this system is the highly expensive cost of the enriched Xenon-124 gas. Therefore, saving this gas inside the system is very important. Unfortunately, by accidental rupture of the window foil or bad function of O-rings, the whole Xenon gas will escape from the system immediately. In this paper, by using computer codes; ALICE91, SRIM and doing some calculations we are going to demonstrate our latest effort for feasibility study of producing I-123 with the above mentioned reactions, but using Xe-124 solid target instead. According to our suggested design, a conical shaped irradiation vessel made of copper with 1 mm thickness, 1 cm outlet diameter, 5 cm length and 12 deg. angle at summit can be fixed inside a liquid nitrogen housing chamber. The Xenon-124 gas will be sent to the inside of this very cold conical trap and eventually deposited on its surface in solid form. Our calculation shows that during bombardment with 17-28 MeV proton energy, the thickness of solidified Xenon layer will remain around .28 mm. Likewise; thermo-dynamical calculation shows that in order to prevent the evaporation of solidified Xenon, the maximum permissible proton beam current for this system should be less than 1.4 μA. According to these working conditions, the production yield of I-123 can be predicted to be around 150 mCi/μAh. (authors)

  7. The Large Underground Xenon (LUX) experiment

    International Nuclear Information System (INIS)

    Akerib, D.S.; Bai, X.; Bedikian, S.; Bernard, E.; Bernstein, A.; Bolozdynya, A.; Bradley, A.; Byram, D.; Cahn, S.B.; Camp, C.; Carmona-Benitez, M.C.; Carr, D.; Chapman, J.J.; Chiller, A.; Chiller, C.; Clark, K.; Classen, T.; Coffey, T.; Curioni, A.

    2013-01-01

    The Large Underground Xenon (LUX) collaboration has designed and constructed a dual-phase xenon detector, in order to conduct a search for Weakly Interacting Massive Particles (WIMPs), a leading dark matter candidate. The goal of the LUX detector is to clearly detect (or exclude) WIMPS with a spin independent cross-section per nucleon of 2×10 −46 cm 2 , equivalent to ∼1event/100kg/month in the inner 100-kg fiducial volume (FV) of the 370-kg detector. The overall background goals are set to have <1 background events characterized as possible WIMPs in the FV in 300 days of running. This paper describes the design and construction of the LUX detector

  8. Modeling Pulse Characteristics in Xenon with NEST

    OpenAIRE

    Mock, Jeremy; Barry, Nichole; Kazkaz, Kareem; Szydagis, Matthew; Tripathi, Mani; Uvarov, Sergey; Woods, Michael; Walsh, Nicholas

    2013-01-01

    A comprehensive model for describing the characteristics of pulsed signals, generated by particle interactions in xenon detectors, is presented. An emphasis is laid on two-phase time projection chambers, but the models presented are also applicable to single phase detectors. In order to simulate the pulse shape due to primary scintillation light, the effects of the ratio of singlet and triplet dimer state populations, as well as their corresponding decay times, and the recombination time are ...

  9. Astrocytic mitochondrial membrane hyperpolarization following extended oxygen and glucose deprivation.

    Directory of Open Access Journals (Sweden)

    Andrej Korenić

    Full Text Available Astrocytes can tolerate longer periods of oxygen and glucose deprivation (OGD as compared to neurons. The reasons for this reduced vulnerability are not well understood. Particularly, changes in mitochondrial membrane potential (Δψ(m in astrocytes, an indicator of the cellular redox state, have not been investigated during reperfusion after extended OGD exposure. Here, we subjected primary mouse astrocytes to glucose deprivation (GD, OGD and combinations of both conditions varying in duration and sequence. Changes in Δψ(m, visualized by change in the fluorescence of JC-1, were investigated within one hour after reconstitution of oxygen and glucose supply, intended to model in vivo reperfusion. In all experiments, astrocytes showed resilience to extended periods of OGD, which had little effect on Δψ(m during reperfusion, whereas GD caused a robust Δψ(m negativation. In case no Δψ(m negativation was observed after OGD, subsequent chemical oxygen deprivation (OD induced by sodium azide caused depolarization, which, however, was significantly delayed as compared to normoxic group. When GD preceded OD for 12 h, Δψ(m hyperpolarization was induced by both GD and subsequent OD, but significant interaction between these conditions was not detected. However, when GD was extended to 48 h preceding OGD, hyperpolarization enhanced during reperfusion. This implicates synergistic effects of both conditions in that sequence. These findings provide novel information regarding the role of the two main substrates of electron transport chain (glucose and oxygen and their hyperpolarizing effect on Δψ(m during substrate deprivation, thus shedding new light on mechanisms of astrocyte resilience to prolonged ischemic injury.

  10. HEMODYNAMIC EFFECTS OF XENON ANESTHESIA IN CHILDREN

    Directory of Open Access Journals (Sweden)

    M. V. Bykov

    2014-01-01

    Full Text Available The study was aimed at hemodynamic effects of xenon on operative interventions in children. Patients and methods: the study involved 30 5-17-year-old children – 10 (33.3% girls and 20 (66.7% boys with ASA score 1-3 admitted for surgical treatment. The children underwent endotracheal anesthesia with xenon-oxygen mixture (Xe:O2 = 60-65:30% and fentanyl (2.5‑3.5  mcg/kg per hour for the following operations: appendectomy – 10 (33.3% patients, herniotomy – 8 (26.7% patients, Ivanissevich procedure – 6 (20.0% patients, plastic surgery of posttraumatic defects of skin and soft tissues – 4 (13.3% patients, abdominal adhesiotomy – 2 (6.7% patients. Central hemodynamics was studied echocardiographically (Philips HD 11, the Netherlands using the Teichholz technique along the cephalocaudal axis (parasternal access. Results: the anesthesia was notable for hemodynamic stability during the operation: as a result, a statistically significant (p < 0.05 increase in systolic, diastolic and mean arterial pressure by 10, 18 and 17%, respectively, was observed. Conclusion: the analysis demonstrated that xenon anesthesia improves lusitropic myocardial function statistically significantly increasing cardiac output by 12% by way of increasing stroke volume by 30%. 

  11. Brain Imaging Using Hyperpolarized 129Xe Magnetic Resonance Imaging.

    Science.gov (United States)

    Chahal, Simrun; Prete, Braedan R J; Wade, Alanna; Hane, Francis T; Albert, Mitchell S

    2018-01-01

    Hyperpolarized (HP) 129 Xe magnetic resonance imaging (MRI) is a novel iteration of traditional MRI that relies on detecting the spins of 1 H. Since 129 Xe is a gaseous signal source, it can be used for lung imaging. Additionally, 129 Xe dissolves in the blood stream and can therefore be detectable in the brain parenchyma and vasculature. In this work, we provide detailed information on the protocols that we have developed to image 129 Xe within the brains of both rodents and human subjects. © 2018 Elsevier Inc. All rights reserved.

  12. Mechanisms of hyperpolarization in regenerated mature motor axons in cat

    DEFF Research Database (Denmark)

    Moldovan, Mihai; Krarup, Christian

    2004-01-01

    We found persistent abnormalities in the recovery of membrane excitability in long-term regenerated motor nerve fibres in the cat as indicated in the companion paper. These abnormalities could partly be explained by membrane hyperpolarization. To further investigate this possibility, we compared...... the changes in excitability in control nerves and long-term regenerated cat nerves (3-5 years after tibial nerve crush) during manoeuvres known to alter axonal membrane Na(+)-K(+) pump function: polarization, cooling to 20 degrees C, reperfusion after 10 min ischaemia, and up to 60 s of repetitive stimulation...

  13. Field dependence of T1 for hyperpolarized [1-13C]pyruvate

    DEFF Research Database (Denmark)

    Chattergoon, N.; Martnez-Santiesteban, F.; Handler, W. B.

    2013-01-01

    conformation and properties of the dissolution media such as buffer composition, solution pH, temperature and magnetic field. We have measured the magnetic field dependence of the spin–lattice relaxation time of hyperpolarized [1-13C]pyruvate using field-cycled relaxometry. [1-13C]pyruvate was hyperpolarized...

  14. Metabolic imaging of patients with prostate cancer using hyperpolarized [1-¹³C]pyruvate

    DEFF Research Database (Denmark)

    Nelson, Sarah J; Kurhanewicz, John; Vigneron, Daniel B

    2013-01-01

    This first-in-man imaging study evaluated the safety and feasibility of hyperpolarized [1-¹³C]pyruvate as an agent for noninvasively characterizing alterations in tumor metabolism for patients with prostate cancer. Imaging living systems with hyperpolarized agents can result in more than 10,000-f...

  15. Facility for the separation of krypton and recuperation of xenon

    International Nuclear Information System (INIS)

    Boell-Djoa, S.H.

    1977-01-01

    A facility is described by means of which the fission inert gases krypton 85 and xenon from spent fuel particles can be separated by fractionated freezing-out and subsequent distillation to such an extent that the xenon contains less than 1 ppb krypton 85. Then, in accordance with the stringent regulations, the krypton can be conveyed to definitive storage in special bottles, whereas the xenon can be released for industrial uses. (orig.) [de

  16. Investigations on a highly luminous condensed xenon scintillator

    International Nuclear Information System (INIS)

    Lansiart, Alain; Seigneur, Alain; Morucci, J.-P.

    1976-12-01

    The means of creating a maximal amount of light by absorption of gamma radiation in condensed xenon were investigated. One of the methods relies on the light production around wires in liquid xenon when several kilovolts are applied to them. Another method uses the saturating vapor present over solid xenon; the electric field pulls out electrons from the solid and accelerates them in the gas phase where they produce light through inelastic collisions [fr

  17. Xenon-based Penning mixtures for proportional counters

    International Nuclear Information System (INIS)

    Ramsey, B.D.; Agrawal, P.C.; National Aeronautics and Space Administration, Huntsville, AL

    1989-01-01

    The choice of quench gas can have a significant effect on the gas gain and energy resolution of gas-filed proportional counters. Details are given on the performance obtained with a variety of quench additives of varying ionization potentials for use in xenon-filled systems. It is confirmed that optimum performance is obtained when the ionization potential is closely matched to the first metastable level of xenon (8.3 eV) as is the case with xenon + trimethylamine and xenon + dimethylamine. For these mixtures the Penning effect is at its strongest. (orig.)

  18. Nuclear Spin Relaxation

    Indian Academy of Sciences (India)

    IAS Admin

    ments have shown that in some cases the nuclear spin systems may be held in special configurations called .... these methods have been commercialized, and used for clinical trials, in which hyperpolarized NMR is used to .... symmetric under exchange, meaning that exchanging the two nuclei leaves the state unchanged.

  19. Appropriate xenon-inhalation speed in xenon-enhanced CT using the end-tidal gas-sampling method

    International Nuclear Information System (INIS)

    Suga, Sadao; Toya, Shigeo; Kawase, Takeshi; Koyama, Hideki; Shiga, Hayao

    1986-01-01

    This report describes some problems when end-tidal xenon gas is substituted for the arterial xenon concentration in xenon-enhanced CT. The authors used a newly developed xenon inhalator with a xenon-gas-concentration analyzer and performed xenon-enhanced CT by means of the ''arterio-venous shunt'' method and the ''end-tidal gas-sampling'' method simultaneously. By the former method, the arterial build-up rate (K) was obtained directly from the CT slices of a blood circuit passing through the phantom. By the latter method, it was calculated from the xenon concentration of end-tidal gas sampled from the mask. The speed of xenon supply was varied between 0.6 - 1.2 L/min. in 11 patients with or without a cerebral lesion. The results revealed that rapid xenon inhalation caused a discrepancy in the arterial K between the ''shunt'' method and the ''end-tidal'' method. This discrepancy may be responsible for the mixing of inhalated gas and expired gas in respiratory dead space, such as the nasal cavity or the mask. The cerebral blood flow was underestimated because of the higher arterial K in the latter method. Too much slow inhalation, however, was timewasting, and it increased the body motion in the subanesthetic state. Therefore, an inhalation speed of the arterial K of as much as 0.2 was ideal to represent the end-tidal xenon concentration for the arterial K in the ''end-tidal gas-sampling'' method. When attention is given to this point, this method may offer a reliable absolute value in xenon-enhanced CT. (author)

  20. Performance test of SAUNA xenon mobile sampling system

    International Nuclear Information System (INIS)

    Hu Dan; Yang Bin; Yang Weigeng; Jia Huaimao; Wang Shilian; Li Qi; Zhao Yungang; Fan Yuanqing; Chen Zhanying; Chang Yinzhong; Liu Shujiang; Zhang Xinjun; Wang Jun

    2011-01-01

    In this article, the structure and basic functions of SAUNA noble gas xenon mobile sampling system are introduced. The sampling capability of this system is about 2.2 mL per day, as a result from a 684-h operation. The system can be transported to designated locations conveniently to collect xenon sample for routine or emergency environment monitoring. (authors)

  1. A pulse generator for xenon lamps

    CERN Document Server

    Janata, E

    2002-01-01

    A pulse generator is described, which enhances the analyzing light emitted from a xenon lamp as used in kinetic photospectrometry experiments. The lamp current is increased to 600 A for a duration of 3 ms; the current is constant within +-0.2% during a time interval of 2 ms. Because of instabilities of the lamp arc during pulsing, the use of the enhanced light source is limited to measuring times up to 500 mu s. The enhancement in light intensity depends on the wavelength and amounts to more than 400-fold in the UV-region.

  2. Simultaneous hyperpolarized 13C-pyruvate MRI and 18F-FDG-PET in cancer (hyperPET)

    DEFF Research Database (Denmark)

    Gutte, Henrik; Hansen, Adam E.; Henriksen, Sarah T.

    2015-01-01

    named this concept hyper PET. Intravenous injection of the hyperpolarized 13C-pyruvate results in an increase of 13C-lactate, 13C-alanine and 13CCO2 (13C-HCO3) resonance peaks relative to the tissue, disease and the metabolic state probed. Accordingly, with dynamic nuclear polarization (DNP) and use......In this paper we demonstrate, for the first time, the feasibility of a new imaging concept - combined hyperpolarized 13C-pyruvate magnetic resonance spectroscopic imaging (MRSI) and 18F-FDG-PET imaging. This procedure was performed in a clinical PET/MRI scanner with a canine cancer patient. We have...... of 13C-pyruvate it is now possible to directly study the Warburg Effect through the rate of conversion of 13C-pyruvate to 13C-lactate. In this study, we combined it with 18F-FDG-PET that studies uptake of glucose in the cells. A canine cancer patient with a histology verified local recurrence...

  3. Electron drift in a large scale solid xenon

    International Nuclear Information System (INIS)

    Yoo, J.; Jaskierny, W.F.

    2015-01-01

    A study of charge drift in a large scale optically transparent solid xenon is reported. A pulsed high power xenon light source is used to liberate electrons from a photocathode. The drift speeds of the electrons are measured using a 8.7 cm long electrode in both the liquid and solid phase of xenon. In the liquid phase (163 K), the drift speed is 0.193 ± 0.003 cm/μs while the drift speed in the solid phase (157 K) is 0.397 ± 0.006 cm/μs at 900 V/cm over 8.0 cm of uniform electric fields. Therefore, it is demonstrated that a factor two faster electron drift speed in solid phase xenon compared to that in liquid in a large scale solid xenon

  4. Potential impact of releases from a new Molybdenum-99 production facility on regional measurements of airborne xenon isotopes

    Energy Technology Data Exchange (ETDEWEB)

    Bowyer, Ted W.; Eslinger, Paul W.; Cameron, Ian M.; Friese, Judah I.; Hayes, James C.; Metz, Lori A.; Miley, Harry S.

    2014-03-01

    The monitoring of the radioactive xenon isotopes 131mXe, 133Xe, 133mXe, and 135Xe is important for the detection of nuclear explosions. While backgrounds of the xenon isotopes are short-lived, they are constantly replenished from activities dominated by the fission-based production of 99Mo used for medical procedures. One of the most critical locations on earth for the monitoring of nuclear explosions is the Korean peninsula, where the Democratic Republic of North Korea (DPRK) has announced that it had conducted three nuclear tests between 2009 and 2013. This paper explores the backgrounds that would be caused by the medium to large scale production of 99Mo in the region of the Korean peninsula.

  5. p-process xenon isotope anomalies in stardust grains from meteorites

    International Nuclear Information System (INIS)

    Ott, U.

    2013-01-01

    Full text: In measurements on 'bulk' samples of meteorites isotopic variations due to the p-process usually have taken a backseat compared to such in s- or r-isotopes, and, in the best case, can be qualitatively attributed to the p-process, with little to no inferences concerning detailed isotopic yields. The situation is different for grains of stardust that survived in primitive meteorites. In fact, isotopically strange xenon was the key feature that led to the first identification of a stardust mineral, nanodiamonds containing xenon with overabundances of up to a factor of ∼2 in both the r-only (≡H-Xe) and p-only (≡L-Xe) isotopes. Relative excesses of the two r-only isotopes ( 134 Xe, 136 Xe) as well as of the two p-only isotopes ( 124 Xe, 126 Xe) are not equal, hence the processes responsible for HL-xenon must differ from the 'average' r- and p-processes as reflected in solar system abundances. However, while considerable effort has been put into explaining H-Xe, there has been little work on the p-side (L-Xe). Relying on scarce nuclear data, Heymann and Dziczkaniec have studied photodisintegration reactions of Xe and Ba seeds in intermediate zones of supernovae and found that the relative production of the p-Xe isotopes depends sensitively on the yield of the (γ, α) reaction on 128 Ba. Another suggestion - applicable to both the r- and p-anomalies in diamond xenon - is that of a 'rapid separation' between stable Xe isotopes and radioactive precursors produced in the 'standard' p- (as well as r-) process. For the p-isotopes to work, this would require the bulk (87%) of 126 Xe to be produced via the 126 Ba precursor, with a half live of ∼100 minutes, in order to explain the high 124 Xe/ 126 Xe. In contrast to diamond xenon, xenon in silicon carbide contains - besides the component from the s-process in their parent AGB stars - 'almost normal' Xe, with indications for 124 Xe/ 126 Xe being few (∼8)% lower than in solar Xe.

  6. New insights into lung diseases using hyperpolarized gas MRI.

    Science.gov (United States)

    Flors, L; Altes, T A; Mugler, J P; de Lange, E E; Miller, G W; Mata, J F; Ruset, I C; Hersman, F W

    2015-01-01

    Hyperpolarized (HP) gases are a new class of contrast agents that permit to obtain high temporal and spatial resolution magnetic resonance images (MRI) of the lung airspaces. HP gas MRI has become important research tool not only for morphological and functional evaluation of normal pulmonary physiology but also for regional quantification of pathologic changes occurring in several lung diseases. The purpose of this work is to provide an introduction to MRI using HP noble gases, describing both the basic principles of the technique and the new information about lung disease provided by clinical studies with this method. The applications of the technique in normal subjects, smoking related lung disease, asthma, and cystic fibrosis are reviewed. Copyright © 2014 SERAM. Published by Elsevier España, S.L.U. All rights reserved.

  7. Nanodiamond-enhanced MRI via in situ hyperpolarization

    Science.gov (United States)

    Waddington, David E. J.; Sarracanie, Mathieu; Zhang, Huiliang; Salameh, Najat; Glenn, David R.; Rej, Ewa; Gaebel, Torsten; Boele, Thomas; Walsworth, Ronald L.; Reilly, David J.; Rosen, Matthew S.

    2017-04-01

    Nanodiamonds are of interest as nontoxic substrates for targeted drug delivery and as highly biostable fluorescent markers for cellular tracking. Beyond optical techniques, however, options for noninvasive imaging of nanodiamonds in vivo are severely limited. Here, we demonstrate that the Overhauser effect, a proton-electron polarization transfer technique, can enable high-contrast magnetic resonance imaging (MRI) of nanodiamonds in water at room temperature and ultra-low magnetic field. The technique transfers spin polarization from paramagnetic impurities at nanodiamond surfaces to 1H spins in the surrounding water solution, creating MRI contrast on-demand. We examine the conditions required for maximum enhancement as well as the ultimate sensitivity of the technique. The ability to perform continuous in situ hyperpolarization via the Overhauser mechanism, in combination with the excellent in vivo stability of nanodiamond, raises the possibility of performing noninvasive in vivo tracking of nanodiamond over indefinitely long periods of time.

  8. Reliability and error analysis on xenon/CT CBF

    International Nuclear Information System (INIS)

    Zhang, Z.

    2000-01-01

    This article provides a quantitative error analysis of a simulation model of xenon/CT CBF in order to investigate the behavior and effect of different types of errors such as CT noise, motion artifacts, lower percentage of xenon supply, lower tissue enhancements, etc. A mathematical model is built to simulate these errors. By adjusting the initial parameters of the simulation model, we can scale the Gaussian noise, control the percentage of xenon supply, and change the tissue enhancement with different kVp settings. The motion artifact will be treated separately by geometrically shifting the sequential CT images. The input function is chosen from an end-tidal xenon curve of a practical study. Four kinds of cerebral blood flow, 10, 20, 50, and 80 cc/100 g/min, are examined under different error environments and the corresponding CT images are generated following the currently popular timing protocol. The simulated studies will be fed to a regular xenon/CT CBF system for calculation and evaluation. A quantitative comparison is given to reveal the behavior and effect of individual error resources. Mixed error testing is also provided to inspect the combination effect of errors. The experiment shows that CT noise is still a major error resource. The motion artifact affects the CBF results more geometrically than quantitatively. Lower xenon supply has a lesser effect on the results, but will reduce the signal/noise ratio. The lower xenon enhancement will lower the flow values in all areas of brain. (author)

  9. Hyperpolarized metabolic MR in the study of cardiac function and disease

    DEFF Research Database (Denmark)

    Lauritzen, M. H.; Søgaard, L. V.; Madsen, Pia Lisbeth

    2014-01-01

    Several diseases of the heart have been linked to an insufficient ability to generate enough energy (ATP) to sustain proper heart function. Hyperpolarized magnetic resonance (MR) is a novel technique that can visualize and quantify myocardial energy metabolism. Hyperpolarization enhances the MR...... signal from a biological molecule of interest by more than 10,000 times, making it possible to measure its cellular uptake and conversion in specific enzymatic pathways in real time. We review the role of hyperpolarized MR in identifying changes in cardiac metabolism in vivo, and present the extensive...... literature on hyperpolarized pyruvate that has been used to characterize cardiac disease in various in vivo models, such as myocardial ischemia, hypertension, diabetes, hyperthyroidism and heart failure. The technical aspects of the technique are presented as well as the challenges of translating...

  10. The potential for large scale uses for fission product xenon

    International Nuclear Information System (INIS)

    Rohrmann, C.A.

    1983-01-01

    Of all fission products in spent, low enrichment, uranium, power reactor fuels xenon is produced in the highest yield - nearly one cubic meter, STP, per metric ton. In aged fuels which may be considered for processing in the U.S. radioactive xenon isotopes approach the lowest limits of detection. The separation from accompanying radioactive 85 Kr is the essential problem; however, this is state of the art technology which has been demonstrated on the pilot scale to yield xenon with pico-curie levels of 85 Kr contamination. If needed for special applications, such levels could be further reduced. Environmental considerations require the isolation of essentially all fission product krypton during fuel processing. Economic restraints assure that the bulk of this krypton will need to be separated from the much more voluminous xenon fraction of the total amount of fission gas. Xenon may thus be discarded or made available for uses at probably very low cost. In contrast with many other fission products which have unique radioactive characteristics which make them useful as sources of heat, gamma and x-rays and luminescence as well as for medicinal diagnostics and therapeutics fission product xenon differs from naturally occurring xenon only in its isotopic composition which gives it a slightly higher atomic weight, because of the much higher concentrations of the 134 X and 136 Xe isotopes. Therefore, fission product xenon can most likely find uses in applications which already exist but which can not be exploited most beneficially because of the high cost and scarcity of natural xenon. Unique uses would probably include applications in improved incandescent light illumination in place of krypton and in human anesthesia

  11. Hyperpolarized Water Perfusion in the Porcine Brain – a Pilot Study

    DEFF Research Database (Denmark)

    Søvsø Szocska Hansen, Esben; Lipsø, Hans Kasper Wigh; Tougaard, Rasmus Stilling

    2017-01-01

    Dynamic Contrast-Enhanced MR (DCE-MR) perfusion assessment with gadolinium contrast agents is currently the most widely used cerebral perfusion MR method. Hyperpolarized water has recently been shown to succeed 13C probes as angiography probe. In this study, we demonstrate the feasibility...... of hyperpolarized water for visualizing the brain vasculature of a large animal in a clinically relevant setting. In detail, reference perfusion values were obtained and large to small arteries could be identified....

  12. Renal MR angiography and perfusion in the pig using hyperpolarized water

    DEFF Research Database (Denmark)

    Lipsø, Hans Kasper Wigh; Hansen, Esben Søvsø Szocska; Tougaard, Rasmus Stilling

    2016-01-01

    at 3 Tesla (T). Approximately 15 mL of hyperpolar-ized water was injected in the renal artery by hand over 4–5 s.Results: A liquid state polarization of 5.3 6 0.9% of 3.8 M pro-tons in 15 mL of deuterium oxide was achieved with a T1of24 6 1 s. This allowed injection through an arterial catheterinto...

  13. A dual-phase xenon TPC for scintillation and ionisation yield measurements in liquid xenon

    Science.gov (United States)

    Baudis, Laura; Biondi, Yanina; Capelli, Chiara; Galloway, Michelle; Kazama, Shingo; Kish, Alexander; Pakarha, Payam; Piastra, Francesco; Wulf, Julien

    2018-05-01

    A small-scale, two-phase (liquid/gas) xenon time projection chamber ( Xurich II) was designed, constructed and is under operation at the University of Zürich. Its main purpose is to investigate the microphysics of particle interactions in liquid xenon at energies below 50 keV, which are relevant for rare event searches using xenon as target material. Here we describe in detail the detector, its associated infrastructure, and the signal identification algorithm developed for processing and analysing the data. We present the first characterisation of the new instrument with calibration data from an internal ^83{m} Kr source. The zero-field light yield is 15.0 and 14.0 photoelectrons/keV at 9.4 and 32.1 keV, respectively, and the corresponding values at an electron drift field of 1 kV/cm are 10.8 and 7.9 photoelectrons/keV. The charge yields at these energies are 28 and 31 electrons/keV, with the proportional scintillation yield of 24 photoelectrons per one electron extracted into the gas phase, and an electron lifetime of 200 μ s. The relative energy resolution, σ /E, is 11.9 and 5.8% at 9.4 and 32.1 keV, respectively using a linear combination of the scintillation and ionisation signals. We conclude with measurements of the electron drift velocity at various electric fields, and compare these to literature values.

  14. Actinide and Xenon reactivity effects in ATW high flux systems

    International Nuclear Information System (INIS)

    Woosley, M.; Olson, K.; Henderson, D.L.

    1995-01-01

    In this paper, initial system reactivity response to flux changes caused by the actinides and xenon are investigated separately for a high flux ATW system. The maximum change in reactivity after a flux change due to the effect of the changing quantities of actinides is generally at least two orders of magnitude smaller than either the positive or negative reactivity effect associated with xenon after a shutdown or start-up. In any transient flux event, the reactivity response of the system to xenon will generally occlude the response due to the actinides

  15. Actinide and xenon reactivity effects in ATW high flux systems

    International Nuclear Information System (INIS)

    Woosley, M.; Olson, K.; Henderson, D. L.; Sailor, W. C.

    1995-01-01

    In this paper, initial system reactivity response to flux changes caused by the actinides and xenon are investigated separately for a high flux ATW system. The maximum change in reactivity after a flux change due to the effect of the changing quantities of actinides is generally at least two orders of magnitude smaller than either the positive or negative reactivity effect associated with xenon after a shutdown or start-up. In any transient flux event, the reactivity response of the system to xenon will generally occlude the response due to the actinides

  16. Actinide and Xenon reactivity effects in ATW high flux systems

    Energy Technology Data Exchange (ETDEWEB)

    Woosley, M. [Univ. of Virginia, Charlottesville, VA (United States); Olson, K.; Henderson, D.L. [Univ. of Wisconsin, Madison, WI (United States)] [and others

    1995-10-01

    In this paper, initial system reactivity response to flux changes caused by the actinides and xenon are investigated separately for a high flux ATW system. The maximum change in reactivity after a flux change due to the effect of the changing quantities of actinides is generally at least two orders of magnitude smaller than either the positive or negative reactivity effect associated with xenon after a shutdown or start-up. In any transient flux event, the reactivity response of the system to xenon will generally occlude the response due to the actinides.

  17. NEST: a comprehensive model for scintillation yield in liquid xenon

    Energy Technology Data Exchange (ETDEWEB)

    Szydagis, M; Barry, N; Mock, J; Stolp, D; Sweany, M; Tripathi, M; Uvarov, S; Walsh, N; Woods, M [University of California, Davis, One Shields Ave., Davis, CA 95616 (United States); Kazkaz, K, E-mail: mmszydagis@ucdavis.edu [Lawrence Livermore National Laboratory, 7000 East Ave., Livermore, CA 94550 (United States)

    2011-10-15

    A comprehensive model for explaining scintillation yield in liquid xenon is introduced. We unify various definitions of work function which abound in the literature and incorporate all available data on electron recoil scintillation yield. This results in a better understanding of electron recoil, and facilitates an improved description of nuclear recoil. An incident gamma energy range of O(1 keV) to O(1 MeV) and electric fields between 0 and O(10 kV/cm) are incorporated into this heuristic model. We show results from a Geant4 implementation, but because the model has a few free parameters, implementation in any simulation package should be simple. We use a quasi-empirical approach with an objective of improving detector calibrations and performance verification. The model will aid in the design and optimization of future detectors. This model is also easy to extend to other noble elements. In this paper we lay the foundation for an exhaustive simulation code which we call NEST (Noble Element Simulation Technique).

  18. NEST: a comprehensive model for scintillation yield in liquid xenon

    International Nuclear Information System (INIS)

    Szydagis, M; Barry, N; Mock, J; Stolp, D; Sweany, M; Tripathi, M; Uvarov, S; Walsh, N; Woods, M; Kazkaz, K

    2011-01-01

    A comprehensive model for explaining scintillation yield in liquid xenon is introduced. We unify various definitions of work function which abound in the literature and incorporate all available data on electron recoil scintillation yield. This results in a better understanding of electron recoil, and facilitates an improved description of nuclear recoil. An incident gamma energy range of O(1 keV) to O(1 MeV) and electric fields between 0 and O(10 kV/cm) are incorporated into this heuristic model. We show results from a Geant4 implementation, but because the model has a few free parameters, implementation in any simulation package should be simple. We use a quasi-empirical approach with an objective of improving detector calibrations and performance verification. The model will aid in the design and optimization of future detectors. This model is also easy to extend to other noble elements. In this paper we lay the foundation for an exhaustive simulation code which we call NEST (Noble Element Simulation Technique).

  19. Modeling pulse characteristics in Xenon with NEST

    International Nuclear Information System (INIS)

    Mock, J; Stolp, D; Szydagis, M; Tripathi, M; Uvarov, S; Woods, M; Walsh, N; Barry, N; Kazkaz, K

    2014-01-01

    A comprehensive model for describing the characteristics of pulsed signals, generated by particle interactions in xenon detectors, is presented. An emphasis is laid on two-phase time projection chambers, but the models presented are also applicable to single phase detectors. In order to simulate the pulse shape due to primary scintillation light, the effects of the ratio of singlet and triplet dimer state populations, as well as their corresponding decay times, and the recombination time are incorporated into the model. In a two phase time projection chamber, when simulating the pulse caused by electroluminescence light, the ionization electron mean free path in gas, the drift velocity, singlet and triplet decay times, diffusion constants, and the electron trapping time, have been implemented. This modeling has been incorporated into a complete software package, which realistically simulates the expected pulse shapes for these types of detectors

  20. Xenon plasma with caesium as additive

    International Nuclear Information System (INIS)

    Stojilkovic, S.M.; Novakovic, N.V.; Zivkovic, L.M.

    1986-01-01

    The concentration dependence of xenon plasma with cesium as additive in the temperature range of 2000 K to 20,000 K is analyzed. Plasma is considered as weakly nonideal in complete local thermodynamic equilibrium and the interaction between plasma and vessel walls is not taken into account. The values of some of the parameters for nonideality of plasma with 1% of cesium (γ=0.01010) and 10% of cesium (γ=0.11111) are computed, for an initial pressure in plasma of p 0 =13,000 Pa and initial temperature T 0 =1000 K. The ratio of electric conductivity of plasma computed by Lorentz's formula and electric conductivity computed by Spitzer's formula in the same temperature interval is also analyzed. (author) 5 figs., 2 tabs., 16 refs

  1. Xenon plasma with caesium as additive

    Energy Technology Data Exchange (ETDEWEB)

    Stojilkovic, S M; Novakovic, N V; Zivkovic, L M

    1986-01-01

    The concentration dependence of xenon plasma with cesium as additive in the temperature range of 2000 K to 20,000 K is analyzed. Plasma is considered as weakly nonideal in complete local thermodynamic equilibrium and the interaction between plasma and vessel walls is not taken into account. The values of some of the parameters for nonideality of plasma with 1% of cesium (..gamma..=0.01010) and 10% of cesium (..gamma..=0.11111) are computed, for an initial pressure in plasma of p/sub 0/=13,000 Pa and initial temperature T/sub 0/=1000 K. The ratio of electric conductivity of plasma computed by Lorentz's formula and electric conductivity computed by Spitzer's formula in the same temperature interval is also analyzed. (author) 5 figs., 2 tabs., 16 refs.

  2. The search for dark matter in xenon: Innovative calibration strategies and novel search channels

    Science.gov (United States)

    Reichard, Shayne Edward

    V. I calculate the inelastic recoil spectra in the standard halo model, compare these to the elastic case, and discuss the expected signatures in a xenon detector, along with implications for existing and future experiments. The combined information from elastic and inelastic scattering will allow for the determination of the dominant interaction channel within one experiment. In addition, the two channels probe different regions of the dark matter velocity distribution and can provide insight into the dark halo structure. The allowed recoil energy domain and the recoil energy at which the integrated inelastic rates start to dominate the elastic channel depend on the mass of the dark matter particle, thus providing a potential handle to constrain its mass. Similarly, now that liquid xenon detectors have reached the tonne scale, they have sensitivity to all flavors of supernova neutrinos via coherent elastic neutrino-nucleus scattering. I consider for the first time a realistic detector model to simulate the expected supernova neutrino signal for different progenitor masses and nuclear equations of state in existing and upcoming dual-phase liquid xenon experiments. I show that the proportional scintillation signal (S2) of a dual-phase detector allows for a clear observation of the neutrino signal and guarantees a particularly low energy threshold, while the backgrounds are rendered negligible during the supernova burst. XENON1T (XENONnT and LZ; DARWIN) experiments will be sensitive to a supernova burst up to 25 (35; 65) kpc from Earth at a significance of more than 5 sigma, observing approximately 35 (123; 704) events from a 27 Solar mass supernova progenitor at 10 kpc. Moreover, it will be possible to measure the average neutrino energy of all flavors, to constrain the total explosion energy, and to reconstruct the supernova neutrino light curve. My results suggest that a large xenon detector such as DARWIN will be competitive with dedicated neutrino telescopes, while

  3. Appropriate xenon-inhalation time in xenon-enhanced CT using the end-tidal gas-sampling method

    Energy Technology Data Exchange (ETDEWEB)

    Asada, Hideo; Furuhata, Shigeru; Onozuka, Satoshi; Uchida, Koichi; Fujii, Koji; Suga, Sadao; Kawase, Takeshi; Toya, Shigeo; Shiga, Hayao

    1988-12-01

    For the end-tidal gas-sampling method of xenon-enhanced CT (Xe-CT), the respective functional images of K, lambda, and the regional cerebral blood flow (rCBF) were studied and compared using the data at 7-, 10-, 15- and 25-minute inhalations. The most appropriate inhalation time of xenon gas was evaluated in 14 clinical cases. An end-tidal xenon curve which represents the arterial xenon concentration was monitored with a xenon analyzer; the xenon concentration was gradually increased to a level of 50% by using a xenon inhalator with a closed circuit to prevent the overestimation of the xenon concentration sampled from the mask. Serial CT scans were taken over a period of 25 minutes of inhalation. The functional images of K, lambda, and rCBF were calculated for serial CT scans for 7, 10, 15 and 25 minutes using Fick's equation. Those various images and absolute values were then compared. The rCBF value of a 15-minute inhalation was approximately 15% greater than that of 25 minutes, while the values of K, lambda, rCBF from a 15-minute inhalation were significantly correlated to those from 25 minutes. The regression line made it possible to estimate 25-minute inhalation values from those of 15 minutes. In imaging, the rCBF mapping of the 15-minute inhalation was found to be more reliable than that of 25 minutes. This study suggests that the minimal time of xenon inhalation is 15 minutes for the end-tidal gas-sampling method. A longer inhalation may be necessary for the estimation of rCBF in the low-flow area, such as the white matter or the pathological region.

  4. Conception and synthesis of new molecular platforms based on cryptophanes. Application for the encapsulation of xenon and metallic cations in aqueous solution

    International Nuclear Information System (INIS)

    Chapellet, Laure-Lise

    2015-01-01

    Cryptophanes are molecular receptors known for their complexation properties of various substrates. Over the last fifteen years, cryptophanes were the subject of numerous studies for they can be used to obtain biosensors for xenon MRI. This field has experienced significant growth and advances to the point were in vivo applications are now envisioned, provided that large amounts of biosensors can be synthesized. More recently, polyphenolic cryptophanes have been studied for their ability to encapsulate monovalent metallic cations like Cs"+ and Tl"+ in aqueous solution. This could lead to applications for depollution of contaminated water sources but would require, once again, the synthesis of large amounts of cryptophanes.The work carried out during this thesis focus on the conception and the synthesis of new molecular platforms that could either be used to obtain new hyper-polarized xenon biosensors or to encapsulate monovalent metallic cations as Cs"+ and Tl"+. Synthetic routes have been developed to produce good amounts of a variety of new hydrosoluble molecular platforms designed for each application. The encapsulation properties of these new host molecules were studied through NMR of the encapsulated nucleus, circular dichroism or isothermal calorimetry. In each case, the new platforms meet the expected requirements thus opening the door for the envisioned applications. (author)

  5. A field-deployable gamma-ray spectrometer utilizing xenon at high pressure

    International Nuclear Information System (INIS)

    Smith, G.C.; Mahler, G.J.; Yu, B.; Salwen, C.; Kane, W.R.; Lemley, J.R.

    1996-01-01

    Prototype gamma-ray spectrometers utilizing xenon gas at high pressure, suitable for applications in the nuclear safeguards, arms control, and nonproliferation communities, have been developed at Brookhaven National Laboratory (BNL). These spectrometers function as ambient-temperature ionization chambers detecting gamma rays with good efficiency in the energy range 50 keV - 2 MeV, with an energy resolution intermediate between semiconductor (Ge) and scintillation (NaI) spectrometers. They are capable of prolonged, low-power operation without a requirement for cryogenic fluids or other cooling mechanisms, and with the addition of small quantities of 3 He gas, can function simultaneously as efficient thermal neutron detectors

  6. Cryogenic system with GM cryocooler for krypton, xenon separation from hydrogen-helium purge gas

    Energy Technology Data Exchange (ETDEWEB)

    Chu, X. X.; Zhang, D. X.; Qian, Y.; Liu, W. [Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800 (China); Zhang, M. M.; Xu, D. [Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190 (China)

    2014-01-29

    In the thorium molten salt reactor (TMSR), fission products such as krypton, xenon and tritium will be produced continuously in the process of nuclear fission reaction. A cryogenic system with a two stage GM cryocooler was designed to separate Kr, Xe, and H{sub 2} from helium purge gas. The temperatures of two stage heat exchanger condensation tanks were maintained at about 38 K and 4.5 K, respectively. The main fluid parameters of heat transfer were confirmed, and the structural heat exchanger equipment and cold box were designed. Designed concentrations after cryogenic separation of Kr, Xe and H{sub 2} in helium recycle gas are less than 1 ppb.

  7. Application of nuclear chemistry in the study of the universe

    International Nuclear Information System (INIS)

    Kuroda, P.K.

    2000-01-01

    Isotopic compositions of the strange Xenon components-HL and the s-type xenon can be explained in a straightforward manner as due to the alteration of the isotopic composition of xenon caused by a combined effect of (a) mass-fractionation, (b) spallation and (c) stellar-temperature neutron-capture reactions. As much as 42.49% of total 136 Xe (Σ 136 Xe) found in the Allende diamond inclusions is 244 Pu fission xenon ( 136f Xe) and the trapped xenon is severely mass-fractionated in such a manner that the lighter xenon isotopes are systematically depleted relative to the heavier isotopes. The relative abundances of 130 Xe and 132 Xe in the trapped xenon component are both markedly enhanced indicating that it was irradiated with a total flux of 1.2 x 10 23 n x cm -2 of stellar-temperature (10 keV) neutrons. The xenon found in the s-type xenon, on the other hand, resemble that of the atmospheric xenon irradiated with a total flux of about 6.0 x 10 23 n x cm -2 of 10 keV neutrons. These results indicate that we are seeing here the effects of nuclear processes occurring inside of a star, such as the exploding supernova. (author)

  8. Radon depletion in xenon boil-off gas

    Energy Technology Data Exchange (ETDEWEB)

    Bruenner, S.; Cichon, D.; Lindemann, S.; Undagoitia, T.M.; Simgen, H. [Max-Planck-Institut fuer Kernphysik, Heidelberg (Germany)

    2017-03-15

    An important background in detectors using liquid xenon for rare event searches arises from the decays of radon and its daughters. We report for the first time a reduction of {sup 222}Rn in the gas phase above a liquid xenon reservoir. We show a reduction factor of >or similar 4 for the {sup 222}Rn concentration in boil-off xenon gas compared to the radon enriched liquid phase. A semiconductor-based α-detector and miniaturized proportional counters are used to detect the radon. As the radon depletion in the boil-off gas is understood as a single-stage distillation process, this result establishes the suitability of cryogenic distillation to separate radon from xenon down to the 10{sup -15} mol/mol level. (orig.)

  9. Matrix of response functions for xenon gamma-ray detector

    International Nuclear Information System (INIS)

    Shustov, A.E.; Vlasik, K.F.; Grachev, V.M.; Dmitrenko, V.V.; Novikov, A.S.; P'ya, S.N.; Ulin, S.E.; Uteshev, Z.M.; Chernysheva, I.V.

    2014-01-01

    An approach of creation of response matrix using simulation GEANT4 gamma-ray Monte-Carlo method has been described for gamma-ray spectrometer based on high pressure xenon impulse ionization chamber with a shielding grid [ru

  10. XAS characterisation of xenon bubbles in uranium dioxide

    Energy Technology Data Exchange (ETDEWEB)

    Martin, P. [CEA Cadarache, DEN/DEC/SESC/LLCC, Bat. 130, 13108 St. Paul Lez Durance (France)], E-mail: martinp@drncad.cea.fr; Garcia, P.; Carlot, G.; Sabathier, C.; Valot, C. [CEA Cadarache, DEN/DEC/SESC/LLCC, Bat. 130, 13108 St. Paul Lez Durance (France); Nassif, V. [CEA Grenoble, DSM/DRFMC/SP2M/NRS, 17 Avenue des Martyrs, 38054 Grenoble Cedex 9 (France); Proux, O. [Laboratoire de Geophysique Interne et Tectonophysique, UMR CNRS/Universite Joseph Fourier, 1381 rue de la Piscine, Domaine Universitaire, 38400 Saint-Martin-D' Heres (France); Hazemann, J.-L. [Institut Neel, CNRS, 25 Avenue des Martyrs, BP 166, 38042 Grenoble Cedex 9 (France)

    2008-06-15

    X-ray absorption spectroscopy experiments were performed on a set of uranium dioxide samples implanted with 10{sup 17} xenon cm{sup -2} at 800 keV (8 at.% at 140 nm). EXAFS measurements performed at 12 K showed that during implantation the gas forms highly pressurised nanometre size inclusions. Bubble pressures were estimated at 2.8 {+-} 0.3 GPa at low temperature. Following the low energy xenon implantation, samples were annealed between 1073 and 1773 K for several hours. Stability of nanometre size highly pressurized xenon aggregates in UO{sub 2} is demonstrated up to 1073 K as for this temperature almost no modification of the xenon environment was observed. Above this temperature, bubbles will trap migrating vacancies and their inner pressure is seen to decrease substantially.

  11. Distribution of xenon between gaseous and liquid CO2

    International Nuclear Information System (INIS)

    Ackley, R.D.; Notz, K.J.

    1976-10-01

    The distribution of xenon at low concentrations between gaseous and liquid CO 2 was measured over essentially the entire liquid range of CO 2 . These measurements involved using a collimated radiation-detection cell to determine the relative quantities of 133 Xe-traced xenon in the separate phases contained in a vertical cylinder under isothermal conditions. The results are expressed in terms of a distribution ratio (mole fraction of xenon in the gaseous phase divided by mole fraction of xenon in the liquid phase) which decreased from 7.53 at -54.8 0 C to 1.10 at 30.5 0 C. These data were used to calculate various other solubility-related quantities

  12. Review of xenon-133 production and related problems

    International Nuclear Information System (INIS)

    Barrachina, M.; Ropero, M.

    1980-01-01

    A literature survey is given on the production methods of fission xenon-133 and related problems, such as purification, metrological and dosimetric aspects, preparation of isotopic solutions, recycling, etc. 127 references are included. (Author) 127 refs

  13. A comparative study of TiN and TiC: Oxidation resistance and retention of xenon at high temperature and under degraded vacuum

    International Nuclear Information System (INIS)

    Gavarini, S.; Bes, R.; Millard-Pinard, N.; Peaucelle, C.; Perrat-Mabilon, A.; Gaillard, C.; Cardinal, S.; Garnier, V.

    2011-01-01

    Dense TiN and TiC samples were prepared by hot pressing using micrometric powders. Xenon species (simulating rare gas fission products) were then implanted into the ceramics. The samples were annealed for 1 h at 1500 deg. C under several degraded vacuums with P O 2 varying from 10 -6 to 2x10 -4 mbars. The oxidation resistance of the samples and their retention properties with respect to preimplanted xenon species were analyzed using scanning electron microscopy, grazing incidence x-ray diffraction, Rutherford backscattering spectrometry, and nuclear backscattering spectrometry. Results indicate that TiC is resistant to oxidation and does not release xenon for P O 2 ≤6x10 -6 mbars. When P O 2 increases, geometric oxide crystallites appear at the surface depending on the orientation and size of TiC grains. These oxide phases are Ti 2 O 3 , Ti 3 O 5 , and TiO 2 . Apparition of oxide crystallites is associated with the beginning of xenon release. TiC surface is completely covered by the oxide phases at P O 2 =2x10 -4 mbars up to a depth of 3 μm and the xenon is then completely released. For TiN samples, the results show a progressive apparition of oxide crystallites (Ti 3 O 5 mainly) at the surface when P O 2 increases. The presence of the oxide crystallites is also directly correlated with xenon release, the more oxide crystallites are growing the more xenon is released. TiN surface is completely covered by an oxide layer at P O 2 =2x10 -4 mbars up to 1 μm. A correlation between the initial fine microstructure of TiN and the properties of the growing layer is suggested.

  14. X-radiation effect on the hyperpolarization of cells, the adeninenucleotide content and the distribution of sodium and potassium ions

    Energy Technology Data Exchange (ETDEWEB)

    Frol' kis, V V [Akademiya Meditsinskikh Nauk Ukrainskoj SSR, Kiev. Inst. Gerontologii

    1975-03-01

    X-radiation prevents the progress of hyperpolarization of muscle and liver cells caused by hormones (estradioldipropyonate, deoxycorticosteron-acetate and insulin) and by the loss of blood. X-radiation offsets the redistribution of K/sup +/ and Na/sup +/ ions caused by hyperpolarization and does not change the level of ATP, ADP, CP and Pi. X-radiation is suggested to affect the hyperpolarization and the ionic shifts via the system of protein biosynthesis.

  15. A new liquid xenon scintillation detector for positron emission tomography

    International Nuclear Information System (INIS)

    Chepel, V.Yu.

    1993-01-01

    A new positron-sensitive detector of annihilation photons filled with liquid xenon is proposed for positron emission tomography. Simultaneous detection of both liquid xenon scintillation and ionization current produces a time resolution of < 1 ns and a position resolution in the tangential direction of the tomograph ring is ∼ 1 mm and in the radial direction is ∼ 5 mm. The advantages of a tomograph with new detectors are discussed. New algorithms of Compton scattering can be used. (author)

  16. Study of regional lung ventilation and perfusion by xenon 133

    International Nuclear Information System (INIS)

    Lombard, Yves.

    1976-01-01

    The present work consists of a regional lung exploration after injection of xenon 133, dissolved in physiological serum, followed a few minutes later by that of 99m Tc-labelled serumalbumin microspheres. The aim is three fold: first of all to study perfusion and ventilation by xenon 133, next to compare the results obtained after xenon 133 and 99 m Tc-labelled microsphere injection, lastly to establish the value of the technique and its routine application. This examination has not solved all problems of lung exploration by xenon 133. For example we deliberately kept to intraveinous injection of the gas dissolved in physiological serum, leaving aside the breathing test. Xenon 133 scintigraphy in our opinion will not tend to replace 99m Tc-labelled microsphere scintigraphy, which has irreplaceable morphological qualities, but will serve as an excellent complement. The basic advantage of xenon 133 is the regional ventilation estimate it provides allowing any anomaly of the lung parenchyma to be located immediately or conversely the functional value of the healthy lung to be established with a view to a surgical removal of a diseased zone [fr

  17. Detection of tobacco smoke deposition by hyperpolarized krypton-83 MRI.

    Science.gov (United States)

    Cleveland, Zackary I; Pavlovskaya, Galina E; Stupic, Karl F; Wooten, Jan B; Repine, John E; Meersmann, Thomas

    2008-02-01

    Despite the importance of the tobacco smoke particulate matter in the lungs to the etiology of pulmonary disease in cigarette smokers, little is currently known about the spatial distribution of particle deposition or the persistence of the resulting deposits in humans, and no satisfactory technique currently exists to directly observe tobacco smoke condensate in airways. In this proof-of-principle work, hyperpolarized (hp) 83Kr MRI and NMR spectroscopy are introduced as probes for tobacco smoke deposition in porous media. A reduction in the hp-83Kr longitudinal (T1) relaxation of up to 95% under near-ambient humidity, pressure and temperature conditions was observed when the krypton gas was brought into contact with surfaces that had been exposed to cigarette smoke. This smoke-induced acceleration of the 83Kr self-relaxation was observed for model glass surfaces that, in some experiments, were coated with bovine lung surfactant extract. However, a similar effect was not observed with hp-(129)Xe indicating that the 83Kr sensitivity to smoke deposition was not caused by paramagnetic species but rather by quadrupolar relaxation due to high adsorption affinity for the smoke deposits. The 83Kr T1 differences between smoke-treated and untreated surfaces were sufficient to produce a strong contrast in variable flip angle FLASH hp-83Kr MRI, suggesting that hp-83Kr may be a promising contrast agent for in vivo pulmonary MRI.

  18. Review of xenon-133 production and related problems; Estudio bibliografico de la produccion de xenon-133 y problemas afines

    Energy Technology Data Exchange (ETDEWEB)

    Barrachina, M; Ropero, M

    1980-07-01

    A literature survey is given on the production methods of fission xenon-133 and related problems, such as purification, metrological and dosimetric aspects, preparation of isotopic solutions, recycling, etc. 127 references are included. (Author) 127 refs.

  19. Sensitivity of gaseous xenon ionisation chambers (1961); Sensibilite des chambres d'ionisation a xenon gazeux (1961)

    Energy Technology Data Exchange (ETDEWEB)

    Schuhl, C [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1960-07-01

    It seems advantageous to fill an ionization chamber with xenon gas when this chamber is used for measuring a low intensity and high energy electron or positron beam, or monitoring a gamma beam. In the study of 5 to 50 MeV electrons, xenon allows for the ionization chamber yield, an improvement of a factor 4,5. (author) [French] Il apparait interessant d'utiliser du xenon comme gaz dans une chambre d'ionisation destinee a mesurer un faisceau d'electrons ou de positons de faible intensite et de grande energie ou pour monitorer un faisceau de gamma. Dans les etudes des electrons de 5 a 50 MeV, le xenon permet de gagner un facteur 4,5 sur l'air pour la sensibilite d'une chambre d'ionisation. (auteur)

  20. Improvements in or relating to trapping and reuse of radioactive xenon

    International Nuclear Information System (INIS)

    Bolmsjoe, M.S.; Persson, B.R.

    1981-01-01

    A method is described suitable for recovering, from a mixture of gases contaning radioactive xenon, a mixture of gases containing an increased concentration of radioactive xenon, which method comprises the steps of passing xenon-containing gas through a bed of activated charcoal to adsorb the xenon therein, thereafter heating the charcoal bed to a temperature within the range of from 200 to 400 0 C, passing a moisture-free sweep gas through the bed when heated to said temperature to desorb xenon therefrom and then collecting the xenon-containing gas thus formed. (author)

  1. Ethane-xenon mixtures under shock conditions

    Science.gov (United States)

    Flicker, Dawn; Magyar, Rudolph; Root, Seth; Cochrane, Kyle; Mattsson, Thomas

    2015-06-01

    Mixtures of light and heavy elements arise in inertial confinement fusion and planetary science. We present results on the physics of molecular scale mixing through a validation study of equation of state (EOS) properties. Density functional theory molecular dynamics (DFT/QMD) at elevated-temperature and pressure is used to obtain the properties of pure xenon, ethane, and various compressed mixture compositions along their principal Hugoniots. To validate the QMD simulations, we performed high-precision shock compression experiments using Sandia's Z-Machine. A bond tracking analysis of the simulations correlates the sharp rise in the Hugoniot curve with completion of dissociation in ethane. DFT-based simulation results compare well with experimental data and are used to provide insight into the dissociation as a function of mixture composition. Interestingly, we find that the compression ratio for complete dissociation is similar for ethane, Xe-ethane, polymethyl-pentene, and polystyrene, suggesting that a limiting compression exists for C-C bonded systems. Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Company, Security Administration under contract DE-AC04-94AL85000.

  2. Optimization of Xenon Difluoride Vapor Delivery

    International Nuclear Information System (INIS)

    Sweeney, Joseph; Marganski, Paul; Kaim, Robert; Wodjenski, Mike; Gregg, John; Yedave, Sharad; Sergi, Steve; Bishop, Steve; Eldridge, David; Zou Peng

    2008-01-01

    Xenon difluoride (XeF 2 ) has been shown to provide many process benefits when used as a daily maintenance recipe for ion implant. Regularly flowing XeF 2 into the ion source cleans the deposits generated by ion source operation. As a result, significant increases in productivity have been demonstrated. However, XeF 2 is a toxic oxidizer that must be handled appropriately. Furthermore, it is a low vapor pressure solid under standard conditions (∼4.5 torr at 25 deg. C). These aspects present unique challenges for designing a package for delivering the chemistry to an ion implanter. To address these challenges, ATMI designed a high-performance, re-usable cylinder for dispensing XeF 2 in an efficient and reliable manner. Data are presented showing specific attributes of the cylinder, such as the importance of internal heat transfer media and the cylinder valve size. The impact of mass flow controller (MFC) selection and ion source tube design on the flow rate of XeF 2 are also discussed. Finally, cylinder release rate data are provided.

  3. Breakdown characteristics of xenon HID Lamps

    Science.gov (United States)

    Babaeva, Natalia; Sato, Ayumu; Brates, Nanu; Noro, Koji; Kushner, Mark

    2009-10-01

    The breakdown characteristics of mercury free xenon high intensity discharge (HID) lamps exhibit a large statistical time lag often having a large scatter in breakdown voltages. In this paper, we report on results from a computational investigation of the processes which determine the ignition voltages for positive and negative pulses in commercial HID lamps having fill pressures of up to 20 atm. Steep voltage rise results in higher avalanche electron densities and earlier breakdown times. Circuit characteristics also play a role. Large ballast resistors may limit current to the degree that breakdown is quenched. The breakdown voltage critically depends on cathode charge injection by electric field emission (or other mechanisms) which in large part controls the statistical time lag for breakdown. For symmetric lamps, ionization waves (IWs) simultaneously develop from the bottom and top electrodes. Breakdown typically occurs when the top and bottom IWs converge. Condensed salt layers having small conductivities on the inner walls of HID lamps and on the electrodes can influence the ignition behavior. With these layers, IWs tend to propagate along the inner wall and exhibit a different structure depending on the polarity.

  4. Mirror dark matter will be confirmed or excluded by XENON1T

    Energy Technology Data Exchange (ETDEWEB)

    Clarke, J.D., E-mail: j.clarke5@pgrad.unimelb.edu.au; Foot, R., E-mail: rfoot@unimelb.edu.au

    2017-03-10

    Mirror dark matter, where dark matter resides in a hidden sector exactly isomorphic to the standard model, can be probed via direct detection experiments by both nuclear and electron recoils if the kinetic mixing interaction exists. In fact, the kinetic mixing interaction appears to be a prerequisite for consistent small scale structure: Mirror dark matter halos around spiral galaxies are dissipative – losing energy via dark photon emission. This ongoing energy loss requires a substantial energy input, which can be sourced from ordinary supernovae via kinetic mixing induced processes in the supernova's core. Astrophysical considerations thereby give a lower limit on the kinetic mixing strength, and indeed lower limits on both nuclear and electron recoil rates in direct detection experiments can be estimated. We show here that potentially all of the viable parameter space will be probed in forthcoming XENON experiments including LUX and XENON1T. Thus, we anticipate that these experiments will provide a definitive test of the mirror dark matter hypothesis.

  5. Mirror dark matter will be confirmed or excluded by XENON1T

    Directory of Open Access Journals (Sweden)

    J.D. Clarke

    2017-03-01

    Full Text Available Mirror dark matter, where dark matter resides in a hidden sector exactly isomorphic to the standard model, can be probed via direct detection experiments by both nuclear and electron recoils if the kinetic mixing interaction exists. In fact, the kinetic mixing interaction appears to be a prerequisite for consistent small scale structure: Mirror dark matter halos around spiral galaxies are dissipative – losing energy via dark photon emission. This ongoing energy loss requires a substantial energy input, which can be sourced from ordinary supernovae via kinetic mixing induced processes in the supernova's core. Astrophysical considerations thereby give a lower limit on the kinetic mixing strength, and indeed lower limits on both nuclear and electron recoil rates in direct detection experiments can be estimated. We show here that potentially all of the viable parameter space will be probed in forthcoming XENON experiments including LUX and XENON1T. Thus, we anticipate that these experiments will provide a definitive test of the mirror dark matter hypothesis.

  6. Bonding of xenon to oxygen in magmas at depth

    Science.gov (United States)

    Leroy, Clémence; Sanloup, Chrystèle; Bureau, Hélène; Schmidt, Burkhard C.; Konôpková, Zuzana; Raepsaet, Caroline

    2018-02-01

    The field of noble gases chemistry has witnessed amazing advances in the last decade with over 100 compounds reported including Xe oxides and Xe-Fe alloys stable at the pressure-temperature conditions of planetary interiors. The chemistry of Xe with planetary materials is nonetheless still mostly ignored, while Xe isotopes are used to trace a variety of key planetary processes from atmosphere formation to underground nuclear tests. It is indeed difficult to incorporate the possibility of Xe reactivity at depth in isotopic geochemical models without a precise knowledge of its chemical environment. The structure of Xe doped hydrous silica-rich melts is investigated by in situ high energy synchrotron X-ray diffraction using resistive heating diamond anvil cells. Obtained pair distribution functions reveal the oxidation of Xe between 0.2 GPa and 4 GPa at high T up to 1000 K. In addition to the usual interatomic distances, a contribution at 2.05 ± 0.05 Å is observed. This contribution is not observed in the undoped melt, and is interpreted as the Xe-O bond, with a coordination number of about 12 consistent with Xe insertion in rings of the melt structure. Xe solubility measurements by electron microprobe and particle induced X-rays emission analysis confirm that Xe and Ar have similar solubility values in wt% in silicate melts. These values are nonetheless an order of magnitude higher than those theoretically calculated for Xe. The formation of Xe-O bonds explains the enhanced solubility of Xe in deep continental crust magmas, revealing a mechanism that could store Xe and fractionate its isotopes. Xenon is indeed atypical among noble gases, the atmosphere being notably depleted in elemental Xe, and very strongly depleted in Xe light isotopes. These observations are known as the 'missing' Xe paradox, and could be solved by the present findings.

  7. Modeling non-linear kinetics of hyperpolarized [1-(13)C] pyruvate in the crystalloid-perfused rat heart

    NARCIS (Netherlands)

    Mariotti, E.; Orton, M. R.; Eerbeek, O.; Ashruf, J. F.; Zuurbier, C. J.; Southworth, R.; Eykyn, T. R.

    2016-01-01

    Hyperpolarized (13)C MR measurements have the potential to display non-linear kinetics. We have developed an approach to describe possible non-first-order kinetics of hyperpolarized [1-(13)C] pyruvate employing a system of differential equations that agrees with the principle of conservation of mass

  8. Output power characteristics of the neutral xenon long laser

    Energy Technology Data Exchange (ETDEWEB)

    Linford, G.J. [TRW Space and Electronics Group, Redondo Beach, CA (United States). Space and Technology Div.

    1994-12-31

    Lasers which oscillate within inhomogeneously broadened gain media exhibit spectral hole burning and concomitant reduction in output power compared with equivalent homogeneously-broadened laser gain media. By increasing the cavity length, it may be possible to demonstrate at least a partial transition from an inhomogeneous laser cavity mode spectrum to a homogeneous spectrum. There are a number of high gain laser lines which are inhomogeneously-broadened transitions in electric discharges of neutral xenon. In neutral xenon lasers, as in the cases of many other gas lasers, the inhomogeneous spectral broadening mechanism arises from Doppler shifts, {Delta}{nu}{sub D}, of individual atoms in thermal motion within the electric discharge comprising the laser gain medium. Optical transitions corresponding to these noble gas atoms have natural linewidths, {Delta}{nu}{sub n}{lt}{Delta}{nu}{sub D}. Simulations of the output power characteristics of the xenon laser were carried out as a function of laser cavity parameters, including the cavity length, L. These calculations showed that when the intracavity mode spacing frequency, c/2L{lt}{Delta}{nu}{sub n}, the inhomogeneously broadened xenon mode spectrum converted to a homogeneously broadened oscillation spectrum with an increase in output power. These simulations are compared with experimental results obtained for the long laser oscillation characteristics of the (5d[5/2]{degree}{sub 2}{r_arrow}6p[3/2]{sub 1}) transition corresponding to the strong, high-gain 3.508 {mu} line in xenon.

  9. Modeling Xenon Purification Systems in a Laser Inertial Fusion Engine

    Science.gov (United States)

    Hopkins, Ann; Gentile, Charles

    2011-10-01

    A Laser Inertial Fusion Engine (LIFE) is a proposed method to employ fusion energy to produce electricity for consumers. However, before it can be built and used as such, each aspect of a LIFE power plant must first be meticulously planned. We are in the process of developing and perfecting models for an exhaust processing and fuel recovery system. Such a system is especially essential because it must be able to recapture and purify expensive materials involved in the reaction so they may be reused. One such material is xenon, which is to be used as an intervention gas in the target chamber. Using Aspen HYSYS, we have modeled several subsystems for exhaust processing, including a subsystem for xenon recovery and purification. After removing hydrogen isotopes using lithium bubblers, we propose to use cryogenic distillation to purify the xenon from remaining contaminants. Aspen HYSYS allows us to analyze predicted flow rates, temperatures, pressures, and compositions within almost all areas of the xenon purification system. Through use of Aspen models, we hope to establish that we can use xenon in LIFE efficiently and in a practical manner.

  10. Core level photoelectron spectroscopy probed heterogeneous xenon/neon clusters

    International Nuclear Information System (INIS)

    Pokapanich, Wandared; Björneholm, Olle; Öhrwall, Gunnar; Tchaplyguine, Maxim

    2017-01-01

    Binary rare gas clusters; xenon and neon which have a significant contrariety between sizes, produced by a co-expansion set up and have been studied using synchrotron radiation based x-ray photoelectron spectroscopy. Concentration ratios of the heterogeneous clusters; 1%, 3%, 5% and 10% were controlled. The core level spectra were used to determine structure of the mixed cluster and analyzed by considering screening mechanisms. Furthermore, electron binding energy shift calculations demonstrated cluster aggregation models which may occur in such process. The results showed that in the case of low mixing ratios of 3% and 5% of xenon in neon, the geometric structures exhibit xenon in the center and xenon/neon interfaced in the outer shells. However, neon cluster vanished when the concentration of xenon was increased to 10%. - Highlights: • Co-expansion setup is suitable for producing binary Xe/Ne clusters. • Appropriate temperature, pressure, and mixing ratios should be strictly controlled. • Low mixing ratio, Xe formed in the core and Xe/Ne interfacing in the outer shell. • High mixing ratio, only pure Xe clusters were detected.

  11. Converging xenon shock waves driven by megagauss magnetic fields

    International Nuclear Information System (INIS)

    Shearer, J.W.; Steinberg, D.J.

    1986-07-01

    We attempted to implode a conducting metal linear at high velocity, and our failure to do so led to switching, or rapidly transferring the field from pushing an aluminum conductor to snow-plowing a half-atmosphere of xenon gas. We successfully initiated convergent xenon gas shocks with the use of a magnetohydrodynamic switch and coaxial high-explosive, flux-compression generators. Principal diagnostics used to study the imploding xenon gas were 133 Xe radioactive tracers, continuous x-ray absorption, and neutron output. We compressed the xenon gas about five to sixfold at a velocity of 10 cm/μs at a radius of 4 cm. The snowplow efficiency was good; going from 13- to 4-cm radius, we lost only about 20% of the mass. The temperature of the imploded sheath was determined by mixing deuterium with the xenon and measuring the neutron output. Using reasonable assumptions about the amount, density, and uniformity of the compressed gas, we estimate that we reached temperatures as high as 155 eV. Energy-loss mechanisms that we encountered included wall ablation and Taylor instabilities of the back surface

  12. Muonium formation in xenon and argon up to 60 atmospheres

    International Nuclear Information System (INIS)

    Kempton, J.R.; Senba, M.; Arseneau, D.J.; Gonzalez, A.C.; Pan, J.J.; Tempelmann, A.; Garner, D.M.; Fleming, D.G.

    1991-01-01

    Results of muon polarization studies in xenon and argon up to 60 atm are reported. In argon for pressures up to 10 atm, the muon polarization is best explained by an epithermalcharge exchange model. Above this pressure, the decrease in P D and increase in P L are ascribed to charge neutralization and spin exchange reactions, respectively, in the radiolysis track. Measurements with Xe/He mixtures with a xenon pressure of 1 atm indicate that the lost polarization in the pure xenon at this pressure is due to inefficient moderation of the muon. As the pressure in pure xenon is increased above 10 atm, we find that P L remains roughly constant and P D begins to increase. The lost fraction may be due to the formation of a XeMu Van der Waals type complex, while P D is ascribed to XeMu + formation. This suggests that spur processes appear to be less important in xenon that in argon. (orig.)

  13. Hugoniot measurements of double-shocked precompressed dense xenon plasmas

    Science.gov (United States)

    Zheng, J.; Chen, Q. F.; Gu, Y. J.; Chen, Z. Y.

    2012-12-01

    The current partially ionized plasmas models for xenon show substantial differences since the description of pressure and thermal ionization region becomes a formidable task, prompting the need for an improved understanding of dense xenon plasmas behavior at above 100 GPa. We performed double-shock compression experiments on dense xenon to determine accurately the Hugoniot up to 172 GPa using a time-resolved optical radiation method. The planar strong shock wave was produced using a flyer plate impactor accelerated up to ˜6 km/s with a two-stage light-gas gun. The time-resolved optical radiation histories were acquired by using a multiwavelength channel optical transience radiance pyrometer. Shock velocity was measured and mass velocity was determined by the impedance-matching methods. The experimental equation of state of dense xenon plasmas are compared with the self-consistent fluid variational calculations of dense xenon in the region of partial ionization over a wide range of pressures and temperatures.

  14. Characterization of zeolites using xenon-129 nuclear magnetic resonance spectroscopy

    Science.gov (United States)

    Jo, Young-Heon

    This study focused on the following three aspects of thermal and thermohaline dynamics in the oceans using long-time series (January 1993 to December 1999) of multi-sensor data. They are (1) heat storage anomaly in the upper layer of the Pacific and the Atlantic using altimeter data; (2) heat and moisture transfer in the Tropical Pacific derived from Bowen ratio (Bo), sensible heat flux (SHF), and latent heat flux (LHF); (3) salt fluxes from the Mediterranean Sea into the North Atlantic through the Mediterranean Eddies (Meddies). The heat storage anomaly derived from XBT data (H' XBT) and altimeter data (H' T/P) was highly correlated, except in a few regions. The non-steric height signals in the altimeter measurements were analyzed. For the Pacific, the wiggle features across 20°N North Pacific caused by long baroclinic waves were found in the areas of low correlation between H'XBT and H' T/P, and were validated with a theoretical dispersion relation. For the Tropical Atlantic, three regions were investigated, i.e., near the Amazon River mouth; the North Equatorial Counter Current; the Guinea Dome. The equilibrium Bowen Ratio (Bo) can be estimated empirically from the sea surface temperature only when the air is saturated with water vapor at the sea surface. In order to estimate the discrepancy between the empirical Bo and the bulk formulated Bo and to correct for the wind-effect and the humidity-effect, the Tropical Atmosphere Ocean data were used. After computing SHF and Bo, the LHF were estimated. The SHF was estimated using wind divergence, which is caused by a convection of airflow. The root mean square of the SHF and LHF were estimated as 3.5Wm-2 and 39.3Wm-2 , respectively. The trajectories and evolution of the Meddies were studied using satellite multi-sensor data analyses. Two experiments, AMUSE and SEMAPHORE were used to directly validate my method. In order to analyze the Meddies' movements, the effect of baroclinic instability resulting from the surface air pressure variations and wind forcing on the Meddies was considered. Finally, the horizontal and vertical viscosity dissipation of the Meddies, using angular velocity measured by floats, was computed and compared with a theoretical model.

  15. Metabolic Imaging of Patients with Prostate Cancer Using Hyperpolarized [1-13C]Pyruvate

    Science.gov (United States)

    Nelson, Sarah J.; Kurhanewicz, John; Vigneron, Daniel B.; Larson, Peder E. Z.; Harzstark, Andrea L.; Ferrone, Marcus; van Criekinge, Mark; Chang, Jose W.; Bok, Robert; Park, Ilwoo; Reed, Galen; Carvajal, Lucas; Small, Eric J.; Munster, Pamela; Weinberg, Vivian K.; Ardenkjaer-Larsen, Jan Henrik; Chen, Albert P.; Hurd, Ralph E.; Odegardstuen, Liv-Ingrid; Robb, Fraser J.; Tropp, James; Murray, Jonathan A.

    2014-01-01

    This first-in-man imaging study evaluated the safety and feasibility of hyperpolarized [1-13C]pyruvate as an agent for noninvasively characterizing alterations in tumor metabolism for patients with prostate cancer. Imaging living systems with hyperpolarized agents can result in more than 10,000-fold enhancement in signal relative to conventional magnetic resonance (MR) imaging. When combined with the rapid acquisition of in vivo 13C MR data, it is possible to evaluate the distribution of agents such as [1-13C]pyruvate and its metabolic products lactate, alanine, and bicarbonate in a matter of seconds. Preclinical studies in cancer models have detected elevated levels of hyperpolarized [1-13C]lactate in tumor, with the ratio of [1-13C]lactate/[1-13C]pyruvate being increased in high-grade tumors and decreased after successful treatment. Translation of this technology into humans was achieved by modifying the instrument that generates the hyperpolarized agent, constructing specialized radio frequency coils to detect 13C nuclei, and developing new pulse sequences to efficiently capture the signal. The study population comprised patients with biopsy-proven prostate cancer, with 31 subjects being injected with hyperpolarized [1-13C]pyruvate. The median time to deliver the agent was 66 s, and uptake was observed about 20 s after injection. No dose-limiting toxicities were observed, and the highest dose (0.43 ml/kg of 230 mM agent) gave the best signal-to-noise ratio for hyperpolarized [1-13C]pyruvate. The results were extremely promising in not only confirming the safety of the agent but also showing elevated [1-13C]lactate/[1-13C]pyruvate in regions of biopsy-proven cancer. These findings will be valuable for noninvasive cancer diagnosis and treatment monitoring in future clinical trials. PMID:23946197

  16. Ion permeabilities in mouse sperm reveal an external trigger for SLO3-dependent hyperpolarization.

    Directory of Open Access Journals (Sweden)

    Julio C Chávez

    Full Text Available Unlike most cells of the body which function in an ionic environment controlled within narrow limits, spermatozoa must function in a less controlled external environment. In order to better understand how sperm control their membrane potential in different ionic conditions, we measured mouse sperm membrane potentials under a variety of conditions and at different external K(+ concentrations, both before and after capacitation. Experiments were undertaken using both wild-type, and mutant mouse sperm from the knock-out strain of the sperm-specific, pH-sensitive, SLO3 K(+ channel. Membrane voltage data were fit to the Goldman-Hodgkin-Katz equation. Our study revealed a significant membrane permeability to both K(+ and Cl(- before capacitation, as well as Na(+. The permeability to both K(+ and Cl(- has the effect of preventing large changes in membrane potential when the extracellular concentration of either ion is changed. Such a mechanism may protect against undesired shifts in membrane potential in changing ionic environments. We found that a significant portion of resting membrane potassium permeability in wild-type sperm was contributed by SLO3 K(+ channels. We also found that further activation of SLO3 channels was the essential mechanism producing membrane hyperpolarization under two separate conditions, 1 elevation of external pH prior to capacitation and 2 capacitating conditions. Both conditions produced a significant membrane hyperpolarization in wild-type which was absent in SLO3 mutant sperm. Hyperpolarization in both conditions may result from activation of SLO3 channels by raising intracellular pH; however, demonstrating that SLO3-dependent hyperpolarization is achieved by an alkaline environment alone shows that SLO3 channel activation might occur independently of other events associated with capacitation. For example sperm may undergo stages of membrane hyperpolarization when reaching alkaline regions of the female genital tract

  17. Control of xenon oscillations in Advanced Heavy Water Reactor via two-stage decomposition

    International Nuclear Information System (INIS)

    Munje, R.K.; Parkhe, J.G.; Patre, B.M.

    2015-01-01

    Highlights: • Singularly perturbed model of Advanced Heavy Water Reactor is explored. • Composite controller is designed using slow subsystem alone, which achieves asymptotic stability. • Nonlinear simulations are carried out under different transient conditions. • Performance of the controller is found to be satisfactory. - Abstract: Xenon induced spatial oscillations developed in large nuclear reactors, like Advanced Heavy Water Reactor (AHWR) need to be controlled for safe operation. Otherwise, a serious situation may arise in which different regions of the core may undergo variations in neutron flux in opposite phase. If these oscillations are left uncontrolled, the power density and rate of change of power at some locations in the reactor core may exceed their respective thermal limits, resulting in fuel failure. In this paper, a state feedback based control strategy is investigated for spatial control of AHWR. The nonlinear model of AHWR including xenon and iodine dynamics is characterized by 90 states, 5 inputs and 18 outputs. The linear model of AHWR, obtained by linearizing the nonlinear equations is found to be highly ill-conditioned. This higher order model of AHWR is first decomposed into two comparatively lower order subsystems, namely, 73rd order ‘slow’ subsystem and 17th order ‘fast’ subsystem using two-stage decomposition. Composite control law is then derived from individual subsystem feedback controls and applied to the vectorized nonlinear model of AHWR. Through the dynamic simulations it is observed that the controller is able to suppress xenon induced spatial oscillations developed in AHWR and the overall performance is found to be satisfactory

  18. Dense xenon nanoplasmas in intense laser fields

    International Nuclear Information System (INIS)

    Hilse, P.; Moll, M.; Schlanges, M.; Bornath, Th.

    2010-01-01

    Complete text of publication follows. One reason for the on-going interest in laser-cluster interactions is the efficient absorption of the radiation energy of near-infrared femtosecond laser pulses by clusters. Consequently, in laser-cluster experiments the emission of highly charged ions, very energetic electrons, higher harmonics, fast fragments as well at strong x-rays in the multi-keV range is observed. The cluster response is highly nonlinear. Different theoretical models and simulations indicate that resonant collective absorption plays a central role. The rapid expansion of irradiated clusters is essential as, at a certain time, the cluster reaches the density fulfilling the resonance condition. This can occur during a single pulse. A better control can be achieved by dual-pulse laser excitation with varying time delay between two pulses. A further optimization is possible by pulse shaping which is a modern tool in laser experiments. With pulse shaping, the dynamics of the system determined by heating, ionization and expansion can be specifically affected. For an understanding of the underlying physical processes in the dynamics of laser-cluster interaction, a theoretical description is presented using a genetic algorithm and basing on the relatively simple nanoplasma model. Recently, experiments as well as calculations were performed for silver clusters. Highly charged silver ions could be produced very efficiently with a pulse structure consisting of a smaller pre-pulse followed by a larger main pulse. The focus of the present contribution is on xenon clusters and their different behavior compared to metallic clusters as silver. Acknowledgements. This work was supported by the Deutsche Forschungsgemeinschaft via SFB 652.

  19. Hyperpolarization moves S4 sensors inward to open MVP, a methanococcal voltage-gated potassium channel.

    Science.gov (United States)

    Sesti, Federico; Rajan, Sindhu; Gonzalez-Colaso, Rosana; Nikolaeva, Natalia; Goldstein, Steve A N

    2003-04-01

    MVP, a Methanococcus jannaschii voltage-gated potassium channel, was cloned and shown to operate in eukaryotic and prokaryotic cells. Like pacemaker channels, MVP opens on hyperpolarization using S4 voltage sensors like those in classical channels activated by depolarization. The MVP S4 span resembles classical sensors in sequence, charge, topology and movement, traveling inward on hyperpolarization and outward on depolarization (via canaliculi in the protein that bring the extracellular and internal solutions into proximity across a short barrier). Thus, MVP opens with sensors inward indicating a reversal of S4 position and pore state compared to classical channels. Homologous channels in mammals and plants are expected to function similarly.

  20. Single Ion Trapping for the Enriched Xenon Observatory

    Energy Technology Data Exchange (ETDEWEB)

    Waldman, Samuel J.; /Stanford U., Phys. Dept. /SLAC

    2006-03-28

    In the last decade, a variety of neutrino oscillation experiments have established that there is a mass difference between neutrino flavors, without determining the absolute neutrino mass scale. The Enriched Xenon Observatory for neutrinoless double beta decay (EXO) will search for the rare decays of xenon to determine the absolute value of the neutrino mass. The experiment uses a novel technique to minimize backgrounds, identifying the decay daughter product in real time using single ion spectroscopy. Here, we describe single ion trapping and spectroscopy compatible with the EXO detector. We extend the technique of single ion trapping in ultrahigh vacuum to trapping in xenon gas. With this technique, EXO will achieve a neutrino mass sensitivity of {approx_equal} .010 eV.

  1. Occupational exposure to xenon-133 among hospital workers

    International Nuclear Information System (INIS)

    Deschamps, M.

    1984-11-01

    During procedures for pulmonary ventilation studies on patients in hospitals, xenon-133 may escape into ambient air. Measurements of air concentrations were required to permit an evaluation of the exposure to which hospital workers are subjected. Two complementary methods of in situ measurements of air concentrations were employed: a commercial air monitor and evacuated blood sampling tubes. Personal dosimeters (TLDs) were exposed simultaneously with the commercial air monitor, and the results were compared. This report presents the results of the measurements of air concentrations during studies on patients. Substantial leakage of xenon-133 was noted, but workers received less than the maximum permissible dose. Personal dosimeters do not permit accurate evaluation of the skin doses resulting from exposure to xenon-133; measurements of air concentrations are required for such evaluation. A number of procedures are recommended to minimize leakage and personnel exposure

  2. Physical interactions of hyperpolarized gas in the lung

    Science.gov (United States)

    Chen, Xiu-Hao Josette

    1999-09-01

    This thesis addresses key interactions of hyperpolarized (HP) gas within the biological environment of the lung using magnetic resonance imaging (MRI). The first excised lung image was obtained in 1994 by Albert et al ., indicating the relative youth of the HP gas MRI field. Thus, there are a multitude of parameters which need to be explored to optimize contrast mechanisms and pulse sequences for in vivo applications. To perform HP gas MRI, both the production of HP gas and development of appropriate MRI pulse sequences were necessary. The apparatus for gas polarization was transferred from Princeton University, then modified and optimized to provide larger quantities and higher polarizations. It was ultimately replaced by a prototype commercial apparatus. Existing MRI pulse sequences were changed to accommodate and exploit the unique situation of non-equilibrium polarized gas. Several physical parameters of the gas relating to structure and function in the lung were investigated. It was found that using a range of excitation powers, acquisition windows, and ventilatory cycle segments yielded dramatically different types of images in the guinea pig. Spatially localized lineshapes of HP 3He showed differentiated peaks (corresponding to frequency shifts) which represent gas in major airways (2 ppm) and alveoli (1-2 ppm). Quantitative maps of the diffusion coefficient (D) showed evidence of free diffusion in the trachea (average of 2.4 cm2/s for 3He and 0.68 cm2/s for 129Xe) and restricted diffusion combined with effects of gas mixtures in the distal pulmonary airspaces (average of 0.16 cm2/s for 3He and 0.021 cm2/s for 129Xe). Experimental measurements were verified with gas mixture and porous media theory for both 3He and 129Xe. The dephasing parameter, T*2 , was mapped showing sensitivity to changes in tidal volume and oxygen level. The T*2 values ranged from 9.2 to 15.9 ms in the intrapulmonary airspaces depending on the breathing paradigm. Experimental results

  3. The high pressure xenon lamp as a source of radiation

    International Nuclear Information System (INIS)

    Heerdt, J.A. ter.

    1979-01-01

    An account is given of an investigation into the radiation properties of a commercially available high pressure xenon lamp (type XBO 900 W) in the spectral range 0.3 to 3 μm. The purpose of the study was to find out whether such a lamp can serve as a (secondary) standard of radiation in spectroscopic and radiometric measurements. The main advantades of the xenon lamp over other secondary standards such as the tungsten strip lamp and the anode of a carbon arc lamp are the high temperature of its discharge and the resulting strong radiation over a broad spectral range. (Auth.)

  4. Dual display of flow/lambda results in xenon CT

    International Nuclear Information System (INIS)

    Lindstrom, W.W.; Gruenaver, L.M.; Dinewitz, I.J.

    1989-01-01

    Measurement of cortical blood flow has always been limited by the unavoidable inclusion of white matter and sulcal cerebrospinal fluid (CSF) in selected regions of interest. Xenon CT gives clear separation of anatomy, but precise ROI tracing is time consuming. CSF and gray and white matter have differing xenon solubilities (lambda), however, so the authors produce two-dimensional histograms of flow/lambda values within an ROI encompassing the desired anatomy and select lambda subregions for tissue-specific quantitative flow/lambda means and deviations. They report how this display is dynamic, allowing the physician to roam around the anatomy at will, with 1-second statistical updating

  5. Search for Dark Matter Interactions using Ionization Yield in Liquid Xenon

    Science.gov (United States)

    Uvarov, Sergey

    Cosmological observations overwhelmingly support the existence of dark matter which constitutes 87% of the universe's total mass. Weakly Interacting Massive Particles (WIMPs) are a prime candidate for dark matter, and the Large Underground Xenon (LUX) experiment aims to a direct-detection of a WIMP-nucleon interaction. The LUX detector is a dual-phase xenon time-projection chamber housed 4,850 feet underground at Sanford Underground Research Facility in Lead, South Dakota. We present the ionization-only analysis of the LUX 2013 WIMP search data. In the 1.04 x 104 kg-days exposure, thirty events were observed out of the 24.8 expected from radioactive backgrounds. We employ a cut-and-count method to set a 1-sided 90% C.L. upper limit for spin-independent WIMP-nucleon cross-sections. A zero charge yield for nuclear-recoils below 0.7 keV is included upper limit calculation. This ionization-only analysis excludes an unexplored region of WIMP-nucleon cross-section for low-mass WIMPs achieving 1.56 x 10-43 cm2 WIMP-nucleon cross-section exclusion for a 5.1 GeV/ c2 WIMP.

  6. Gamma-ray detector based on high pressure xenon for radiation and environmental safety

    International Nuclear Information System (INIS)

    Kutny, V.E.; Rybka, A.V.; Davydov, L.N.; Pudov, A.O.; Sokolov, S.A.; Kholomeyev, G.A.; Melnikov, S.I.; Turchin, A.A.

    2017-01-01

    Gamma-spectrometers based on compressed xenon gas assigned for monitoring the reactors and the radiation background at nuclear power plants, non-proliferation of radioactive materials, supervision and control over the radiation background in the environmentally disadvantaged areas, and other applications, are very promising detectors with excellent performance characteristics. This article reports on the results of the first stage of work on the creation of the portable gamma-spectrometer based on compressed xenon that is unique for Ukraine. In order to work with ultra-pure gases under pressure, the complex cryogenic installation for Xe purification and detector filling was designed and manufactured. The installation was made of specially cleaned components, equipped with a heating system for the degassing of the inner walls, and is able of maintaining high vacuum down to 2 centre dot 10"-"9 mbar. A prototype ionization chamber for the use in portable HP Xe detectors was developed and made. For the detector testing, a spectrometric channel based on high-quality electronic components was designed and manufactured. In the initial experiments, a study of the properties of the purified Xe mixed with the dopant H_2 was carried out. The assessment of the lifetime of charge carriers τ in the working gas at a pressure of 30 bar gave the value of τ > 150 μs

  7. Characterization and flip angle calibration of 13C surface coils for hyperpolarization studies

    DEFF Research Database (Denmark)

    Hansen, Rie Beck; Gutte, Henrik; Larsen, Majbrit M E

    The aim of the present work is to address the challenge of optimal The aim of the present work is to address the challenge of optimal flflip angle calibration of ip angle calibration of C surface coils in C surface coils in hyperpolarization studies. To this end, we characterize the spatial pro h...

  8. Role of endothelium-derived hyperpolarization in the vasodilatation of rat intrarenal arteries

    DEFF Research Database (Denmark)

    Pinilla, Estéfano; Sánchez-Pina, Ana; Muñoz Picos, Mercedes

    2016-01-01

    Background and purpose: Endothelium-dependent vasodilation plays an important role in the regulation of vascular tone in different vascular beds. Besides the release of prostacyclin (PGI2) and nitric oxide (NO), the endothelium mediates vasodilation through endothelium-derived hyperpolarization (...

  9. Large dose hyperpolarized water with dissolution-DNP at high magnetic field

    DEFF Research Database (Denmark)

    Lipsø, Hans Kasper Wigh; Bowen, Sean; Rybalko, Oleksandr

    2016-01-01

    was polarized and dissolved in a fluid path compatible with clinical polarizers. The volume of hyperpolarized water produced by this method enables angiography and perfusion measurements in large animals, as well as NMR experiments for studies of e.g. proton exchange and polarization transfer to other nuclei....

  10. Irreversible Catalyst Activation Enables Hyperpolarization and Water Solubility for NMR Signal Amplification by Reversible Exchange

    Science.gov (United States)

    2016-09-12

    G. R.; Duckett, S. B.; Spiess , H. W.; Schreiber, L. M.; Münnemann, K. Continuous Proton Hyperpolarization Via SABRE and Hollow Fibre Membranes. Proc...M.; Kindervater, P.; Raich, H.-P.; Bargon, J.; Spiess , H. W.; Muennemann, K. Continuous H-1 and C-13 Signal Enhancement in NMR Spectroscopy and MRI

  11. Phase dependency of electrotonic spread of hyperpolarizing current pulses in the rabbit sinoatrial node

    NARCIS (Netherlands)

    Duivenvoorden, J. J.; Bouman, L. N.; Bukauskas, F. F.; Opthof, T.; Jongsma, H. J.

    1990-01-01

    Electrotonic current spread in the SA node of the rabbit was measured by means of hyperpolarizing current pulses (1 to 10 microA, 60 ms), which were injected intracellularly through a K(+)-perfused suction electrode. The pulses were applied at the beginning, middle or end of the diastolic

  12. Hyperpolarized 3-helium MR imaging of the lungs: testing the concept of a central production facility

    International Nuclear Information System (INIS)

    Beek, E.J.R. van; Schmiedeskamp, J.; Filbir, F.; Heil, W.; Wolf, M.; Otten, E.; Wild, J.M.; Paley, M.N.J.; Fichele, S.; Woodhouse, N.; Swift, A.; Knitz, F.; Mills, G.H.

    2003-01-01

    The aim of this study was to test the feasibility of a central production facility with distribution network for implementation of hyperpolarized 3-helium MRI. The 3-helium was hyperpolarized to 50-65% using a large-scale production facility based at a university in Germany. Using a specially designed transport box, containing a permanent low-field shielded magnet and dedicated iron-free glass cells, the hyperpolarized 3-helium gas was transported via airfreight to a university in the UK. At this location, the gas was used to perform in vivo MR experiments in normal volunteers and patients with chronic obstructive lung diseases. Following initial tests, the transport (road-air-road cargo) was successfully arranged on six occasions (approximately once per month). The duration of transport to imaging averaged 18 h (range 16-20 h), which was due mainly to organizational issues such as working times and flight connections. During the course of the project, polarization at imaging increased from 20% to more than 30%. A total of 4 healthy volunteers and 8 patients with chronic obstructive pulmonary disease were imaged. The feasibility of a central production facility for hyperpolarized 3-helium was demonstrated. This should enable a wider distribution of gas for this novel technology without the need for local start-up costs. (orig.)

  13. Synthesis of long T silicon nanoparticles for hyperpolarized Si magnetic resonance imaging

    DEFF Research Database (Denmark)

    Atkins, T.M.; Ganguly, S.; Kauzlarich, S.M.

    2013-01-01

    silicide (Na Si) and silicon tetrachloride (SiCl) and were surface functionalized with a variety of passivating ligands. The synthesis scheme results in particles of diameter ~10 nm with long size-adjusted Si spin-lattice relaxation (T) times (>600 s), which are retained after hyperpolarization by low...

  14. In vivo single-shot (13)C spectroscopic imaging of hyperpolarized metabolites by spatiotemporal encoding

    DEFF Research Database (Denmark)

    Schmidt, Rita; Laustsen, Christoffer; Dumez, Jean-Nicolas

    2014-01-01

    are necessary. Several approaches have been customized for hyperpolarized (13)C MRI, including CSI with a center-out k-space encoding, EPSI, and spectrally selective pulses in combination with spiral EPI acquisitions. Recent studies have described the potential of single-shot alternatives based...... temporal) data sets were obtained at 7T from a murine lymphoma tumor model....

  15. Apparent rate constant mapping using hyperpolarized [1-(13) C]pyruvate

    DEFF Research Database (Denmark)

    Khegai, O.; Schulte, R. F.; Janich, M. A.

    2014-01-01

    Hyperpolarization of [1-13C]pyruvate in solution allows real-time measurement of uptake and metabolism using MR spectroscopic methods. After injection and perfusion, pyruvate is taken up by the cells and enzymatically metabolized into downstream metabolites such as lactate, alanine, and bicarbona...

  16. Hyperpolarized 1-13C Pyruvate Imaging of Porcine Cardiac Metabolism shift by GIK Intervention

    DEFF Research Database (Denmark)

    Søvsø Szocska Hansen, Esben; Tougaard, Rasmus Stilling; Mikkelsen, Emmeli

    to evaluate the general feasibility to detect an imposed shift in metabolic substrate utilization during metabolic modulation with glucose, insulin and potassium (GIK) infusion. This study demonstrates that hyperpolarized 13C-pyruvate, in a large animal, is a feasible method for cardiac studies, and...

  17. Simultaneous hyperpolarized 13C-pyruvate MRI and 18F-FDG-PET in cancer (hyperPET)

    DEFF Research Database (Denmark)

    Borgwardt, Henrik Gutte; Hansen, Adam Espe; Henriksen, Sarah T.

    2015-01-01

    have named this concept hyper PET. Intravenous injection of the hyperpolarized (13)C-pyruvate results in an increase of (13)C-lactate, (13)C-alanine and (13)C-CO2 ((13)C-HCO3) resonance peaks relative to the tissue, disease and the metabolic state probed. Accordingly, with dynamic nuclear polarization......In this paper we demonstrate, for the first time, the feasibility of a new imaging concept - combined hyperpolarized (13)C-pyruvate magnetic resonance spectroscopic imaging (MRSI) and (18)F-FDG-PET imaging. This procedure was performed in a clinical PET/MRI scanner with a canine cancer patient. We...... (DNP) and use of (13)C-pyruvate it is now possible to directly study the Warburg Effect through the rate of conversion of (13)C-pyruvate to (13)C-lactate. In this study, we combined it with (18)F-FDG-PET that studies uptake of glucose in the cells. A canine cancer patient with a histology verified...

  18. Simultaneous Hyperpolarized 13C-Pyruvate MRI and 18F-FDG PET (HyperPET) in 10 Dogs with Cancer

    DEFF Research Database (Denmark)

    Gutte, Henrik; Hansen, Adam E; Larsen, Majbrit M E

    2015-01-01

    with biopsy-verified spontaneous malignant tumors were included for imaging. All dogs underwent a protocol of simultaneous (18)F-FDG PET, anatomic MR, and hyperpolarized dynamic nuclear polarization with (13)C-pyruvate imaging. The data were acquired using a combined clinical PET/MR imaging scanner. We found...... that combined (18)F-FDG PET and (13)C-pyruvate MRS imaging was possible in a single session of approximately 2 h. A continuous workflow was obtained with the injection of (18)F-FDG when the dogs was placed in the PET/MR scanner. (13)C-MRS dynamic acquisition demonstrated in an axial slab increased (13)C......With the introduction of combined PET/MR spectroscopic (MRS) imaging, it is now possible to directly and indirectly image the Warburg effect with hyperpolarized (13)C-pyruvate and (18)F-FDG PET imaging, respectively, via a technique we have named hyperPET. The main purpose of this present study...

  19. Real-time tracking of dissociation of hyperpolarized 89Y-DTPA: a model for degradation of open-chain Gd3+ MRI contrast agents

    Science.gov (United States)

    Ferguson, Sarah; Niedbalski, Peter; Parish, Christopher; Kiswandhi, Andhika; Kovacs, Zoltan; Lumata, Lloyd

    Gadolinium (Gd) complexes are widely used relaxation-based clinical contrast agents in magnetic resonance imaging (MRI). Gd-based MRI contrast agents with open-chain ligand such as Gd-DTPA, commercially known as magnevist, are less stable compared to Gd complexes with macrocyclic ligands such as GdDOTA (Dotarem). The dissociation of Gd-DPTA into Gd ion and DTPA ligand under certain biological conditions such as high zinc levels can potentially cause kidney damage. Since Gd is paramagnetic, direct NMR detection of the Gd-DTPA dissociation is quite challenging due to ultra-short relaxation times. In this work, we have investigated Y-DTPA as a model for Gd-DPTA dissociation under high zinc content solutions. Using dissolution dynamic nuclear polarization (DNP), the 89Y NMR signal is amplified by several thousand-fold. Due to the the relatively long T1 relaxation time of 89Y which translates to hyperpolarization lifetime of several minutes, the dissociation of Y-DTPA can be tracked in real-time by hyperpolarized 89Y NMR spectroscopy. Dissociation kinetic rates and implications on the degradation of open-chain Gd3+ MRI contrast agents will be discussed. This work was supported by the U.S. Department of Defense Award Number W81XWH-14-1-0048 and by the Robert A. Welch Foundation research Grant Number AT-1877.

  20. Xenon-induced power oscillations in a generic small modular reactor

    Science.gov (United States)

    Kitcher, Evans Damenortey

    As world demand for energy continues to grow at unprecedented rates, the world energy portfolio of the future will inevitably include a nuclear energy contribution. It has been suggested that the Small Modular Reactor (SMR) could play a significant role in the spread of civilian nuclear technology to nations previously without nuclear energy. As part of the design process, the SMR design must be assessed for the threat to operations posed by xenon-induced power oscillations. In this research, a generic SMR design was analyzed with respect to just such a threat. In order to do so, a multi-physics coupling routine was developed with MCNP/MCNPX as the neutronics solver. Thermal hydraulic assessments were performed using a single channel analysis tool developed in Python. Fuel and coolant temperature profiles were implemented in the form of temperature dependent fuel cross sections generated using the SIGACE code and reactor core coolant densities. The Power Axial Offset (PAO) and Xenon Axial Offset (XAO) parameters were chosen to quantify any oscillatory behavior observed. The methodology was benchmarked against results from literature of startup tests performed at a four-loop PWR in Korea. The developed benchmark model replicated the pertinent features of the reactor within ten percent of the literature values. The results of the benchmark demonstrated that the developed methodology captured the desired phenomena accurately. Subsequently, a high fidelity SMR core model was developed and assessed. Results of the analysis revealed an inherently stable SMR design at beginning of core life and end of core life under full-power and half-power conditions. The effect of axial discretization, stochastic noise and convergence of the Monte Carlo tallies in the calculations of the PAO and XAO parameters was investigated. All were found to be quite small and the inherently stable nature of the core design with respect to xenon-induced power oscillations was confirmed. Finally, a

  1. Transition from linear to nonlinear sputtering of solid xenon

    DEFF Research Database (Denmark)

    Dutkiewicz, L.; Pedrys, R.; Schou, Jørgen

    1995-01-01

    Self-sputtering of solid xenon has been studied with molecular dynamics simulations as a model system for the transition from dominantly linear to strongly nonlinear effects. The simulation covered the projectile energy range from 20 to 750 eV. Within a relatively narrow range from 30 to 250 e...

  2. Supernova Neutrino Physics with Xenon Dark Matter Detectors

    NARCIS (Netherlands)

    Reichard, S.; Lang, R.F.; McCabe, C.; Selvi, M.; Tamborra, I.

    2017-01-01

    The dark matter experiment XENON1T is operational and sensitive to all flavors of neutrinos emitted from a supernova. We show that the proportional scintillation signal (S2) allows for a clear observation of the neutrino signal and guarantees a particularly low energy threshold, while the

  3. Improved Fluid Perturbation Theory: Equation of state for Fluid Xenon

    OpenAIRE

    Li, Qiong; Liu, Hai-Feng; Zhang, Gong-Mu; Zhao, Yan-Hong; Tian, Ming-Feng; Song, Hai-Feng

    2016-01-01

    The traditional fluid perturbation theory is improved by taking electronic excitations and ionizations into account, in the framework of average ion spheres. It is applied to calculate the equation of state for fluid Xenon, which turns out in good agreement with the available shock data.

  4. Xenon tissue/blood partition coefficient for pig urinary bladder

    DEFF Research Database (Denmark)

    Nielsen, K K; Bülow, J; Nielsen, S L

    1990-01-01

    In four landrace pigs the tissue/blood partition coefficient (lambda) for xenon (Xe) for the urinary bladder was calculated after chemical analysis for lipid, water and protein content and determination of the haematocrit. The coefficients varied from bladder to bladder owing to small differences...

  5. Radon removal from gaseous xenon with activated charcoal

    Energy Technology Data Exchange (ETDEWEB)

    Abe, K.; Hieda, K.; Hiraide, K.; Hirano, S.; Kishimoto, Y.; Kobayashi, K.; Koshio, Y. [Kamioka Observatory, Institute for Cosmic Ray Research, University of Tokyo, Kamioka, Hida, Gifu 506-1205 (Japan); Liu, J.; Martens, K. [Institute for the Physics and Mathematics of the Universe, University of Tokyo, Kashiwa, Chiba 277-8582 (Japan); Moriyama, S. [Kamioka Observatory, Institute for Cosmic Ray Research, University of Tokyo, Kamioka, Hida, Gifu 506-1205 (Japan); Nakahata, M. [Kamioka Observatory, Institute for Cosmic Ray Research, University of Tokyo, Kamioka, Hida, Gifu 506-1205 (Japan); Institute for the Physics and Mathematics of the Universe, University of Tokyo, Kashiwa, Chiba 277-8582 (Japan); Nishiie, H.; Ogawa, H.; Sekiya, H.; Shinozaki, A. [Kamioka Observatory, Institute for Cosmic Ray Research, University of Tokyo, Kamioka, Hida, Gifu 506-1205 (Japan); Suzuki, Y. [Kamioka Observatory, Institute for Cosmic Ray Research, University of Tokyo, Kamioka, Hida, Gifu 506-1205 (Japan); Institute for the Physics and Mathematics of the Universe, University of Tokyo, Kashiwa, Chiba 277-8582 (Japan); Takachio, O.; Takeda, A.; Ueshima, K.; Umemoto, D. [Kamioka Observatory, Institute for Cosmic Ray Research, University of Tokyo, Kamioka, Hida, Gifu 506-1205 (Japan); and others

    2012-01-01

    Many low background experiments using xenon need to remove radioactive radon to improve their sensitivities. However, no method of continually removing radon from xenon has been described in the literature. We studied a method to remove radon from xenon gas through an activated charcoal trap. From our measurements we infer a linear relationship between the mean propagation velocity v{sub Rn} of radon and v{sub Xe} of xenon in the trap with v{sub Rn}/v{sub Xe}=(0.96{+-}0.10) Multiplication-Sign 10{sup -3} at -85 Degree-Sign C. As the mechanism for radon removal in this charcoal trap is its decay, knowledge of this parameter allows us to design an efficient radon removal system for the XMASS experiment. The verification of this system found that it reduces radon by a factor of 0.07, which is in line with its expected average retention time of 14.8 days for radon.

  6. Electric field measurements in a xenon discharge using Spark spectroscopy

    NARCIS (Netherlands)

    Wagenaars, E.; Bowden, M.D.; Kroesen, G.M.W.

    2005-01-01

    Measurements of electric field distributions in a low-pressure xenon discharge are presented. The measurement technique is based on Stark spectroscopy, using a 2 + 1 excitation scheme with fluorescence dip detection. Electric fields can be measured by detecting Stark shifts of high-lying Rydberg

  7. Damage of copper by low energy xenon ions

    International Nuclear Information System (INIS)

    Babad-Zakhryapin, A.A.; Popenko, V.A.

    1988-01-01

    Changes in the copper crystal structure bombarded by xenon ions with 30-150 eV energy are studied. Foils of MOb copper mark, 10 mm in diameter and 100 μm thickness, are irradiated. The initial specimens are annealed in vacuum during 1 h at 900 K temperature. The specimens are bombarded by xenon ions in a water-cooled holder. A TE-O type accelerator serves as a xenon ion source. The ion energy varies within 30 to 150 eV range. The ion flux density is 8x10 16 ion/(cm 2 xs). It is shown that crystal structure variations at deep depths are observed not only at high (>1 keV), but at low ion energies down to several dozens of electronvolt as well. The crystal structure variation on copper irradiation by xenon ions with 30-150 eV energy is followed by formation of defects like dislocation loops, point defects in the irradiated target bulk

  8. Charge States of Krypton and Xenon in the Solar Wind

    Science.gov (United States)

    Bochsler, Peter; Fludra, Andrzej; Giunta, Alessandra

    2017-09-01

    We calculate charge state distributions of Kr and Xe in a model for two different types of solar wind using the effective ionization and recombination rates provided from the OPEN_ADAS data base. The charge states of heavy elements in the solar wind are essential for estimating the efficiency of Coulomb drag in the inner corona. We find that xenon ions experience particularly low Coulomb drag from protons in the inner corona, comparable to the notoriously weak drag of protons on helium ions. It has been found long ago that helium in the solar wind can be strongly depleted near interplanetary current sheets, whereas coronal mass ejecta are sometimes strongly enriched in helium. We argue that if the extraordinary variability of the helium abundance in the solar wind is due to inefficient Coulomb drag, the xenon abundance must vary strongly. In fact, a secular decrease of the solar wind xenon abundance relative to the other heavier noble gases (Ne, Ar, Kr) has been postulated based on a comparison of noble gases in recently irradiated and ancient samples of ilmenite in the lunar regolith. We conclude that decreasing solar activity and decreasing frequency of coronal mass ejections over the solar lifetime might be responsible for a secularly decreasing abundance of xenon in the solar wind.

  9. Commissioning of the XENON1T liquid level measurement system

    Energy Technology Data Exchange (ETDEWEB)

    Geis, Christopher [Institut fuer Physik, Johannes Gutenberg-Universitaet, Mainz (Germany)

    2016-07-01

    Two-phase xenon time projection chambers (TPCs) have been operated very successfully in direct detection experiments for dark matter. This kind of detector uses liquid xenon as the sensitive target and is operated in two-phase (liquid/gas) mode, where the liquid level needs to be monitored and controlled with sub-millimeter precision. We present the installation, commissioning and first measurement data of two kinds of level meters operated in the XENON1T TPC: short level meters are three-plated capacitors measuring the level of the liquid-gas interface with a measurement range h∼5 mm and a resolution of ΔC/h∼1 pF/mm. The long level meters are cylindrical double-walled capacitors, measuring the overall filling level of the XENON1T TPC at a measurement range of h=1.4 m and a resolution of ΔC/h∼0.1 pF/mm. Further, we present the design and programming of the readout electronic based on the UTI chip by Smartec, which allows to read all six levelmeters simultaneously.

  10. Removing krypton from xenon by cryogenic distillation to the ppq level

    Science.gov (United States)

    Aprile, E.; Aalbers, J.; Agostini, F.; Alfonsi, M.; Amaro, F. D.; Anthony, M.; Arneodo, F.; Barrow, P.; Baudis, L.; Bauermeister, B.; Benabderrahmane, M. L.; Berger, T.; Breur, P. A.; Brown, A.; Brown, E.; Bruenner, S.; Bruno, G.; Budnik, R.; Bütikofer, L.; Calvén, J.; Cardoso, J. M. R.; Cervantes, M.; Cichon, D.; Coderre, D.; Colijn, A. P.; Conrad, J.; Cussonneau, J. P.; Decowski, M. P.; de Perio, P.; Di Gangi, P.; Di Giovanni, A.; Diglio, S.; Duchovni, E.; Eurin, G.; Fei, J.; Ferella, A. D.; Fieguth, A.; Franco, D.; Fulgione, W.; Gallo Rosso, A.; Galloway, M.; Gao, F.; Garbini, M.; Geis, C.; Goetzke, L. W.; Grandi, L.; Greene, Z.; Grignon, C.; Hasterok, C.; Hogenbirk, E.; Huhmann, C.; Itay, R.; Kaminsky, B.; Kessler, G.; Kish, A.; Landsman, H.; Lang, R. F.; Lellouch, D.; Levinson, L.; Calloch, M. Le; Lin, Q.; Lindemann, S.; Lindner, M.; Lopes, J. A. M.; Manfredini, A.; Maris, I.; Undagoitia, T. Marrodán; Masbou, J.; Massoli, F. V.; Masson, D.; Mayani, D.; Meng, Y.; Messina, M.; Micheneau, K.; Miguez, B.; Molinario, A.; Murra, M.; Naganoma, J.; Ni, K.; Oberlack, U.; Orrigo, S. E. A.; Pakarha, P.; Pelssers, B.; Persiani, R.; Piastra, F.; Pienaar, J.; Piro, M.-C.; Pizzella, V.; Plante, G.; Priel, N.; Rauch, L.; Reichard, S.; Reuter, C.; Rizzo, A.; Rosendahl, S.; Rupp, N.; Saldanha, R.; Santos, J. M. F. dos; Sartorelli, G.; Scheibelhut, M.; Schindler, S.; Schreiner, J.; Schumann, M.; Lavina, L. Scotto; Selvi, M.; Shagin, P.; Shockley, E.; Silva, M.; Simgen, H.; Sivers, M. v.; Stein, A.; Thers, D.; Tiseni, A.; Trinchero, G.; Tunnell, C.; Upole, N.; Wang, H.; Wei, Y.; Weinheimer, C.; Wulf, J.; Ye, J.; Zhang, Y.; Cristescu, I.

    2017-05-01

    The XENON1T experiment aims for the direct detection of dark matter in a detector filled with 3.3 tons of liquid xenon. In order to achieve the desired sensitivity, the background induced by radioactive decays inside the detector has to be sufficiently low. One major contributor is the β -emitter ^{85}Kr which is present in the xenon. For XENON1T a concentration of natural krypton in xenon ^{nat}Kr/Xe McCabe-Thiele approach is described. The system demonstrated a krypton reduction factor of 6.4\\cdot 10^5 with thermodynamic stability at process speeds above 3 kg/h. The resulting concentration of ^{nat}Kr/Xe<26 ppq is the lowest ever achieved, almost one order of magnitude below the requirements for XENON1T and even sufficient for future dark matter experiments using liquid xenon, such as XENONnT and DARWIN.

  11. Diffusion of hyperpolarized {sup 129}Xe in the lung: a simplified model of {sup 129}Xe septal uptake and experimental results

    Energy Technology Data Exchange (ETDEWEB)

    Patz, Samuel; Muradyan, Iga; Dabaghyan, Mikayel; Washko, George R; Hatabu, Hiroto; Butler, James P [Center for Pulmonary Functional Imaging, Departments of Radiology and Pulmonary Medicine, Brigham and Women' s Hospital and Harvard Medical School, Boston, MA 02115 (United States); Hrovat, Mirko I, E-mail: patz@bwh.harvard.edu [Mirtech, Inc., Brockton, MA 02301 (United States)

    2011-01-15

    We used hyperpolarized {sup 129}Xe NMR to measure pulmonary alveolar surface area per unit gas volume S{sub A}/V{sub gas}, alveolar septal thickness h and capillary transit time {tau}, three critical determinants of the lung's primary role as a gas exchange organ. An analytical solution for a simplified diffusion model is described, together with a modification of the xenon transfer contrast imaging technique utilizing 90{sup 0} radio-frequency pulses applied to the dissolved phase, rather than traditional 180{sup 0} pulses. With this approach, three-dimensional (3D) maps of S{sub A}/V{sub gas} were obtained. We measured global S{sub A}/V{sub gas}, h and {tau} in four normal subjects, two subjects with mild interstitial lung disease (ILD) and two subjects with mild chronic obstructive pulmonary disease (COPD). In normals, S{sub A}/V{sub gas} decreased with increasing lung volume from {approx}320 to 80 cm{sup -1}; both h{approx}13 {mu}m and {tau}{approx}1.5 s were relatively constant. For the two ILD subjects, h was, respectively, 36 and 97% larger than normal, quantifying an increased gas/blood tissue barrier; S{sub A}/V{sub gas} and {tau} were normal. The two COPD subjects had S{sub A}/V{sub gas} values {approx}25% that of normals, quantifying septal surface loss in emphysema; h and {tau} were normal. These are the first noninvasive, non-radiation-based, quantitative measurements of h and {tau} in patients with pulmonary disease.

  12. PRAMANA Cluster radioactivity in xenon isotopes

    Indian Academy of Sciences (India)

    exotic decay or cluster radioactivity was first predicted by sandulescu et al [1] in. 1980 on the basis of ... separator by 58Ni(58Ni, 2n) reaction and carbon clusters were searched for by means of solid state nuclear ..... Lett. 55, 582 (1985). [22] D N Poenaru, W Greiner, K Depta, M Ivascu, D Mazilu and A Sandulescu, At. Data.

  13. Review of the adsorption of radioactive krypton and xenon on activated charcoal

    International Nuclear Information System (INIS)

    Underhill, D.W.; Moeller, D.W.

    1981-01-01

    This report summarizes the results of a critical review of the published literature on the adsorption of radioactive krypton and xenon on activated charcoal. This review, which was supported by the Advisory Committee on Reactor Safeguards, US Nuclear Regulatory Commission, showed that (a) individual charcoals have a wide range of adsoprtion coefficients and therefore the performance of a given bed is heavily dependent on the quality of the charcoal it contains; (b) because of the detrimental effects of mass transfer on noble gas adsorption, consideration should be given to including this factor in developing technical specifications for adsorption beds; and (c) additional research is needed on the determination of the inter-relationship of moisture and temperature and their effects on adsorption bed performance

  14. Study of neutronic problems related to the xenon instability in the pressurized water reactor

    International Nuclear Information System (INIS)

    Mathonniere, G.

    1988-03-01

    Xenon instabilities lead to increase initial errors. So it is extremely difficult to get an accurate calculation schema able to deal with these problems which are very important for electrical grid whose electronuclear output is large. The main task was to build a tridimensional calculation schema including nuclear, thermal hydraulic feedback. It was qualified by comparing its results with an actual experiment. Many technical problems were investigated through analytical studies or calculation results: time step, spatial mesh, finite element, convergence criterion, modelization for grids and fast control rod moves. Moreover, a 1D model, for less expensive, was studied. Its comparison with the 3D results allowed to check its accuracy and to validate the modelization of the radial laplacien and the modelization of the control rods [fr

  15. Use of intraperitoneal xenon-133 for imaging of intestinal strangulation in small bowel obstruction. [Rats; Dogs

    Energy Technology Data Exchange (ETDEWEB)

    Bulkley, G.B.; Gharagozloo, F.; Alderson, P.O.; Horn, S.D.; Zuidema, G.D.

    1981-01-01

    Intraperitoneal xenon-133 dissolved in saline solution was evaluated for the detection of early strangulation in a reproducible model of segmental intestinal obstruction in rats and dogs. There was a highly significant delay inexternally detected isotope washout from animals with strangulated loops compared with normal, sham operated and simple (nonstrangulated) obstruction control groups. Corresponding anterior abdominal gamma camera images showed marked retention of isotope at 1 hour in the strangulation obstruction groups and the sites of this activity corresponsed to the location of the ischemic loops. Blinded readings of these images by nuclear radiologists showed this method to be highly accurate for the detection of strangulation in these animal models. This method should be directly applicable to patients with intestinal obstruction.

  16. Use of intraperitoneal xenon-133 for imaging of intestinal strangulation in small bowel obstruction

    International Nuclear Information System (INIS)

    Bulkley, G.B.; Gharagozloo, F.; Alderson, P.O.; Horn, S.D.; Zuidema, G.D.

    1981-01-01

    Intraperitoneal xenon-133 dissolved in saline solution was evaluated for the detection of early strangulation in a reproducible model of segmental intestinal obstruction in rats and dogs. There was a highly significant delay inexternally detected isotope washout from animals with strangulated loops compared with normal, sham operated and simple (nonstrangulated) obstruction control groups. Corresponding anterior abdominal gamma camera images showed marked retention of isotope at 1 hour in the strangulation obstruction groups and the sites of this activity corresponsed to the location of the ischemic loops. Blinded readings of these images by nuclear radiologists showed this method to be highly accurate for the detection of strangulation in these animal models. This method should be directly applicable to patients with intestinal obstruction

  17. Search for double beta decay processes of {sup 124}Xe with XENON100 and XENON1T

    Energy Technology Data Exchange (ETDEWEB)

    Fieguth, Alexander [IKP, Westfaelische-Wilhelms-Universitaet Muenster (Germany)

    2016-07-01

    Driven by the search for dark matter particles the XENON dark matter project recently installed its next stage multi-ton experiment XENON1T at the LNGS, which will probe the spin-indpendent-WIMP-Nucleon cross section down to 2.10{sup -47} cm{sup 2}. Besides its main purpose different particle physics topics can be addressed by the taken data. One example are the double beta decay processes of natural isotope {sup 124}Xe. This isotope is expected to decay via two-neutrino double electron capture (2νECEC) and due to its high Q-value of 2864 keV additionally through 2νβ{sup +}β{sup +}. Since these processes have not been detected so far, there is only a lower limit the respective half-life (e.g. > 4.7.10{sup 21} yr for 2νECEC). A detection of the 2νECEC is possible using XENON1T data by looking for its clear signature of secondary X-rays or Auger electrons and at least new lower half-life limits for all other decay channels can be obtained. While these processes are expected from standard model physics, a detection of a decay without neutrinos (e.g 0νECEC) would hint towards beyond the standard model physics and could derive conclusions on the neutrino mass. Until XENON1T is taking data, the search for all processes can be tested in the recorded data of its predecessor XENON100.

  18. Fast Padé Transform Accelerated CSI for Hyperpolarized MRS

    DEFF Research Database (Denmark)

    Hansen, Esben Szocska Søvsø; Kim, Sun; Miller, Jack J

    2016-01-01

    The fast Padé transform (FPT) is a method of spectral analysis that can be used to reconstruct nuclear magnetic resonance spectra from truncated free induction decay signals with superior robustness and spectral resolution compared with conventional Fourier analysis. The aim of this study is to s...

  19. Investigating tumor perfusion and metabolism using multiple hyperpolarized 13C compounds: HP001, pyruvate and urea

    DEFF Research Database (Denmark)

    von Morze, Cornelius; Larson, Peder E.Z.; Hu, Simon

    2012-01-01

    The metabolically inactive hyperpolarized agents HP001 (bis-1,1-(hydroxymethyl)-[1-13C]cyclopropane-d8) and urea enable a new type of perfusion magnetic resonance imaging based on a direct signal source that is background-free. The addition of perfusion information to metabolic information obtained...... (T1=95 s ex vivo, 32 s in vivo at 3 T) using a pulse sequence with balanced steady-state free precession and ramped flip angle over time for efficient utilization of the hyperpolarized magnetization and three-dimensional echo-planar spectroscopic imaging of urea copolarized with [1-13C...... of separate dynamic HP001 imaging and copolarized pyruvate/urea imaging were compared. A strong and significant correlation (R=0.73, P=.02) detected between the urea and HP001 data confirmed the value of copolarizing urea with pyruvate for simultaneous assessment of perfusion and metabolism....

  20. Dysfunctional Hyperpolarization-Activated Cyclic Nucleotide-gated Ion Channels in Cardiac Diseases

    Directory of Open Access Journals (Sweden)

    Xiaoqi Zhao

    Full Text Available Abstract Hyperpolarization-activated cyclic nucleotide-gated (HCN channels are reverse voltage-dependent, and their activation depends on the hyperpolarization of the membrane and may be directly or indirectly regulated by the cyclic adenosine monophosphate (cAMP or other signal-transduction cascades. The distribution, quantity and activation states of HCN channels differ in tissues throughout the body. Evidence exhibits that HCN channels play critical roles in the generation and conduction of the electrical impulse and the physiopathological process of some cardiac diseases. They may constitute promising drug targets in the treatment of these cardiac diseases. Pharmacological treatment targeting HCN channels is of benefit to these cardiac conditions.

  1. Two-photon resonant, stimulated processes in krypton and xenon

    International Nuclear Information System (INIS)

    Miller, J.C.

    1988-11-01

    Both on-axis and conical emissions have been observed following two-photon pumping of the 5p states of krypton and the 6p', 7p, 8p, and 4f states of xenon. In the former case, coherent emissions from the 5p states to the 5s are observed, and in the latter case, many p→s, d→p, and f→d cascade emissions are observed. By analogy to the well-studied alkali and alkaline earth examples, the emissions are discussed in terms of amplified spontaneous emission (ASE), stimulated hyper-Raman scattering, and parametric four-wave mixing. The physical processes responsible for the conical emission and for intensity anomalies in the xenon p→s emissions are not understood at present. Interference effects due to coherent cancellation between competing excitation pathways may be occurring. 4 refs., 3 figs

  2. Xenon NMR measurements of permeability and tortuosity in reservoir rocks.

    Science.gov (United States)

    Wang, Ruopeng; Pavlin, Tina; Rosen, Matthew Scott; Mair, Ross William; Cory, David G; Walsworth, Ronald Lee

    2005-02-01

    In this work we present measurements of permeability, effective porosity and tortuosity on a variety of rock samples using NMR/MRI of thermal and laser-polarized gas. Permeability and effective porosity are measured simultaneously using MRI to monitor the inflow of laser-polarized xenon into the rock core. Tortuosity is determined from measurements of the time-dependent diffusion coefficient using thermal xenon in sealed samples. The initial results from a limited number of rocks indicate inverse correlations between tortuosity and both effective porosity and permeability. Further studies to widen the number of types of rocks studied may eventually aid in explaining the poorly understood connection between permeability and tortuosity of rock cores.

  3. Ionization yield from electron tracks in liquid xenon

    International Nuclear Information System (INIS)

    Voronova, T.Ya.; Kipsanov, M.A.; Kruglov, A.A.; Obodovskij, I.M.; Pokachalov, S.G.; Shilov, V.A.; Khristich, E.B.

    1989-01-01

    Methods for calculating coefficients K β , characterizing ionization yield from electron track in liquid xenon are considered. K β calculation is conducted on the base of experimental data on K parameter characterizing ionization yield from a certain combination of photo-, Compton-and Auger electron tracks. K parameter measurements are conducted in liquid xenon at 170 K temperature within 10-30 keV gamma- and X radiation energy ranges. Calculated dependence of K β and K coefficients on the energy in a wide (5-500 keV) range is presented. K β values obtained can be applied for calculating the energy resolution of a gamma-spectrometer and linearity of its calibration characteristics if the electric field intensity in the spectrometer does not exceed some kV/cm

  4. Modal analysis of temperature feedback in oscillations induced by xenon

    International Nuclear Information System (INIS)

    Passos, E.M. dos.

    1976-01-01

    The flux oscillations induced by Xenon distribution in homogeneous thermal reactors are studied treating the space dependence through the modal expansion technique and the stability limits against power oscillations and spatial oscillations are determined. The effect of the feedbacks due to Xenon and temperature coefficient on the linear stability of the free system is investigated employing several number of terms in the transient expansion, considering the various sizes of the reactor. The heat transfer model considered includes one term due to cooling proportional to the temperature. A PWR model reactor is utilized for numerical calculations. It is found that a slightly higher temperature feedback coefficient is necessary for stability against power oscillations when larger number of terms in the transient modal expansion is maintained. (author)

  5. Search for magnetic inelastic dark matter with XENON100

    Energy Technology Data Exchange (ETDEWEB)

    Aprile, E.; Anthony, M. [Physics Department, Columbia University, New York, NY 10027 (United States); Aalbers, J.; Breur, P.A.; Brown, A. [Nikhef and the University of Amsterdam, Science Park, 1098XG Amsterdam (Netherlands); Agostini, F.; Bruno, G. [INFN-Laboratori Nazionali del Gran Sasso and Gran Sasso Science Institute, 67100 L' Aquila (Italy); Alfonsi, M. [Institut für Physik and Exzellenzcluster PRISMA, Johannes Gutenberg-Universität Mainz, 55099 Mainz (Germany); Amaro, F.D. [LIBPhys, Department of Physics, University of Coimbra, 3004-516 Coimbra (Portugal); Arneodo, F.; Benabderrahmane, M.L. [New York University Abu Dhabi, Abu Dhabi (United Arab Emirates); Barrow, P.; Baudis, L. [Physik-Institut, University of Zurich, 8057 Zurich (Switzerland); Bauermeister, B.; Calvén, J. [Oskar Klein Centre, Department of Physics, Stockholm University, AlbaNova, Stockholm SE-10691 (Sweden); Berger, T.; Brown, E. [Department of Physics, Applied Physics and Astronomy, Rensselaer Polytechnic Institute, Troy, NY 12180 (United States); Bruenner, S. [Max-Planck-Institut für Kernphysik, 69117 Heidelberg (Germany); Budnik, R. [Department of Particle Physics and Astrophysics, Weizmann Institute of Science, Rehovot 7610001 (Israel); Bütikofer, L., E-mail: lukas.buetikofer@lhep.unibe.ch, E-mail: xenon@lngs.infn.it [Physikalisches Institut, Universität Freiburg, 79104 Freiburg (Germany); and others

    2017-10-01

    We present the first search for dark matter-induced delayed coincidence signals in a dual-phase xenon time projection chamber, using the 224.6 live days of the XENON100 science run II. This very distinct signature is predicted in the framework of magnetic inelastic dark matter which has been proposed to reconcile the modulation signal reported by the DAMA/LIBRA collaboration with the null results from other direct detection experiments. No candidate event has been found in the region of interest and upper limits on the WIMP's magnetic dipole moment are derived. The scenarios proposed to explain the DAMA/LIBRA modulation signal by magnetic inelastic dark matter interactions of WIMPs with masses of 58.0 GeV/c{sup 2} and 122.7 GeV/c{sup 2} are excluded at 3.3 σ and 9.3 σ, respectively.

  6. Depth distribution of martensite in xenon implanted stainless steels

    International Nuclear Information System (INIS)

    Johansen, A.; Johnson, E.; Sarholt-Kristensen, L.; Steenstrup, S.; Hayashi, N.; Sakamoto, I.

    1989-01-01

    The amount of stress-induced martensite and its distribution in depth in xenon implanted austenitic stainless steel poly- and single crystals have been measured by Rutherford backscattering and channeling analysis, depth selective conversion electron Moessbauer spectroscopy, cross-sectional transmission electron microscopy and x-ray diffraction analysis. In low nickel 17/7, 304 and 316 commercial stainless steels and in 17:13 single crystals the martensitic transformation starts at the surface and develops towards greater depth with increasing xenon fluence. The implanted layer is nearly completely transformed, and the interface between martensite and austenite is rather sharp and well defined. In high nickel 310 commercial stainless steel and 15:19 and 20:19 single crystals, on the other hand, only insignificant amounts of martensite are observed. (orig.)

  7. Dark matter sensitivity of multi-ton liquid xenon detectors

    International Nuclear Information System (INIS)

    Schumann, Marc; Bütikofer, Lukas; Baudis, Laura; Kish, Alexander; Selvi, Marco

    2015-01-01

    We study the sensitivity of multi ton-scale time projection chambers using a liquid xenon target, e.g., the proposed DARWIN instrument, to spin-independent and spin-dependent WIMP-nucleon scattering interactions. Taking into account realistic backgrounds from the detector itself as well as from neutrinos, we examine the impact of exposure, energy threshold, background rejection efficiency and energy resolution on the dark matter sensitivity. With an exposure of 200 t × y and assuming detector parameters which have been already demonstrated experimentally, spin-independent cross sections as low as 2.5 × 10 −49 cm 2 can be probed for WIMP masses around 40 GeV/c 2 . Additional improvements in terms of background rejection and exposure will further increase the sensitivity, while the ultimate WIMP science reach will be limited by neutrinos scattering coherently off the xenon nuclei

  8. Configuration interaction in charge exchange spectra of tin and xenon

    Science.gov (United States)

    D'Arcy, R.; Morris, O.; Ohashi, H.; Suda, S.; Tanuma, H.; Fujioka, S.; Nishimura, H.; Nishihara, K.; Suzuki, C.; Kato, T.; Koike, F.; O'Sullivan, G.

    2011-06-01

    Charge-state-specific extreme ultraviolet spectra from both tin ions and xenon ions have been recorded at Tokyo Metropolitan University. The electron cyclotron resonance source spectra were produced from charge exchange collisions between the ions and rare gas target atoms. To identify unknown spectral lines of tin and xenon, atomic structure calculations were performed for Sn14+-Sn17+ and Xe16+-Xe20+ using the Hartree-Fock configuration interaction code of Cowan (1981 The Theory of Atomic Structure and Spectra (Berkeley, CA: University of California Press)). The energies of the capture states involved in the single-electron process that occurs in these slow collisions were estimated using the classical over-barrier model.

  9. Dissolution Dynamic Nuclear Polarization capability study with fluid path

    DEFF Research Database (Denmark)

    Malinowski, Ronja Maja; Lipsø, Hans Kasper Wigh; Lerche, Mathilde Hauge

    2016-01-01

    Signal enhancement by hyperpolarization is a way of overcoming the low sensitivity in magnetic resonance; MRI in particular. One of the most well-known methods, dissolution Dynamic Nuclear Polarization, has been used clinically in cancer patients. One way of ensuring a low bioburden of the hyperp......Signal enhancement by hyperpolarization is a way of overcoming the low sensitivity in magnetic resonance; MRI in particular. One of the most well-known methods, dissolution Dynamic Nuclear Polarization, has been used clinically in cancer patients. One way of ensuring a low bioburden...... of the hyperpolarized product is by use of a closed fluid path that constitutes a barrier to contamination. The fluid path can be filled with the pharmaceuticals, i.e. imaging agent and solvents, in a clean room, and then stored or immediately used at the polarizer. In this study, we present a method of filling...

  10. Investigation of Spectral Characteristics of Pulsed Xenon Lamps for Combined Photochemical Degradation of Organometallic Compounds in Liquid Radioactive Waste

    Directory of Open Access Journals (Sweden)

    M. A. Mishakov

    2017-01-01

    Full Text Available The paper considers the composition of liquid radioactive wastes from the nuclear plants. Using traditional ways to extract organometallic compounds formed, when using the deactivation solutions to clean the surfaces of nuclear plant rooms, are complicated. The paper studies the edge-cutting methods of solving this problem. Its proposal is to use a combined ultraviolet treatment for organometallic compounds degradation based on ethylenediaminetetraacetic acid (EDTA via pulsed xenon lamps. A potential use of the tubular and spherical geometry lamps is examined and advantages, disadvantages and features of these lamps are described. Instead of the pure EDTA the experiments used its disodium salt (Na2-EDTA. The hydrogen peroxide was used as an extra oxidizer. Absorption spectrums of solutions with various Na2-EDTA - hydrogen peroxide ratio were measured. It is found that the absorbance curve maximum is in the shortwave spectrum region (λ < 210 nm. The use of amalgam lamps of monochromatic radiation at wavelength λ = 254 nm will result only in formation of hydroxyl radicals but direct destruction processes of EDTA molecules due to radiation will be rare, and this decreases efficiency of their use.The spectral radiation characteristics of various continuum spectrum pulsed xenon lamps was measured. The experimental data expressed in relative units were compared with the emission spectrum of an absolutely black body. The paper shows that in spherical lamps high brightness temperature can be reached. Thus, in spherical lamps it is possible to obtain a spectrum, which is in maximum correlation with the absorption spectrum of the solutions under study, thereby making them a prospective radiation source for photo-degradation of EDTA compounds. For drawing a final conclusion it is necessary to conduct researches in order to compare Na2-EDTA degradation via tubular and spherical xenon lamps.

  11. Imaging cerebral 2-ketoisocaproate metabolism with hyperpolarized (13)C Magnetic Resonance Spectroscopic Imaging

    DEFF Research Database (Denmark)

    Butt, Sadia Asghar; Søgaard, Lise Vejby-Christensen; Magnusson, Peter O.

    2012-01-01

    The branched chain amino acid transaminase (BCAT) has an important role in nitrogen shuttling and glutamate metabolism in the brain. The purpose of this study was to describe the cerebral distribution and metabolism of hyperpolarized 2-keto[1-(13)C]isocaproate (KIC) in the normal rat using magnet...... & Metabolism advance online publication, 28 March 2012; doi:10.1038/jcbfm.2012.34....

  12. Resonant four-wave mixing processes in xenon

    International Nuclear Information System (INIS)

    Yiu, Y.M.; Bonin, K.D.; McIlrath, T.J.

    1982-01-01

    Two-photon resonantly enhanced four-wave mixing processes in xenon involving the intermediate states were utilized to generate coherent VUV radiation at several discrete wavelengths between 125.9 nm and 101.8 nm. Maximum efficiencies of the order of 10-4 were achieved. The use of these processes for producing tunable VUV output with Xe is given and generation of tunable VUV using two-photon resonances in other rare gases is discussed

  13. Quench gases for xenon- (and krypton-)filled proportional counters

    International Nuclear Information System (INIS)

    Ramsey, B.D.; Agrawal, P.C.

    1988-01-01

    Xenon-filled proportional counters are used extensively in astronomy, particularly in the hard X-ray region. The choice of quench gas can have a significant effect on the operating characteristics of the instrument although the data necessary to make the choice are not easily obtainable. We present results which detail the performance obtained from both cylindrical and parallel field geometries for a wide variety of readily available, ultrahigh or research grade purity, quench gases. (orig.)

  14. Application of xenon difluoride for surface modification of polymers

    International Nuclear Information System (INIS)

    Barsamyan, G.B.; Belokonov, K.V.; Vargasova, N.A.; Sokolov, V.B.; Chaivanov, B.B.; Zubov, V.P.

    1994-01-01

    Chemical interaction between xenon difluoride (XeF 2 ) and polymeric materials was investigated. It was shown that the reaction occurs on the surface of solid polymer layer and brings to chemical modification of the surface properties of the polymer leaving the bulk properties unchanged. The results of various analysis of the fluorinated samples (IR, FTIR-ATR, ESCA, bulk analysis etc) are presented. The mechanism of reaction is proposed. 12 refs.; 13 figs

  15. Two-dimensional readout in a liquid xenon ionisation chamber

    CERN Document Server

    Solovov, V; Ferreira-Marques, R; Lopes, M I; Pereira, A; Policarpo, Armando

    2002-01-01

    A two-dimensional readout with metal strips deposited on both sides of a glass plate is investigated aiming to assess the possibility of its use in a liquid xenon ionisation chamber for positron emission tomography. Here, we present results obtained with an alpha-source. It is shown that position resolution of <=1 mm, fwhm, can be achieved for free charge depositions equivalent to those due to gamma-rays with energy from 220 down to 110 keV.

  16. Observation of a barium xenon exciplex within a large argon cluster.

    Science.gov (United States)

    Briant, M; Gaveau, M-A; Mestdagh, J-M

    2010-07-21

    Spectroscopic measurements provide fluorescence and excitation spectra of a single barium atom codeposited with xenon atoms on argon clusters of average size approximately 2000. The spectra are studied as a function of the number of xenon atoms per cluster. The excitation spectrum with approximately 10 xenon atoms per cluster is qualitatively similar to that observed when no xenon atom is present on the cluster. It consists of two bands located on each side of the 6s6p (1)P-6s(2) (1)S resonance line of the free barium. In contrast, the fluorescence spectrum differs qualitatively since a barium-xenon exciplex is observed, which has no counterpart in xenon free clusters. In particular an emission is observed, which is redshifted by 729 cm(-1) with respect to the Ba(6s6p (1)P-6s(2) (1)S) resonance line.

  17. A catalyzing phantom for reproducible dynamic conversion of hyperpolarized [1-¹³C]-pyruvate.

    Science.gov (United States)

    Walker, Christopher M; Lee, Jaehyuk; Ramirez, Marc S; Schellingerhout, Dawid; Millward, Steven; Bankson, James A

    2013-01-01

    In vivo real time spectroscopic imaging of hyperpolarized ¹³C labeled metabolites shows substantial promise for the assessment of physiological processes that were previously inaccessible. However, reliable and reproducible methods of measurement are necessary to maximize the effectiveness of imaging biomarkers that may one day guide personalized care for diseases such as cancer. Animal models of human disease serve as poor reference standards due to the complexity, heterogeneity, and transient nature of advancing disease. In this study, we describe the reproducible conversion of hyperpolarized [1-¹³C]-pyruvate to [1-¹³C]-lactate using a novel synthetic enzyme phantom system. The rate of reaction can be controlled and tuned to mimic normal or pathologic conditions of varying degree. Variations observed in the use of this phantom compare favorably against within-group variations observed in recent animal studies. This novel phantom system provides crucial capabilities as a reference standard for the optimization, comparison, and certification of quantitative imaging strategies for hyperpolarized tracers.

  18. A catalyzing phantom for reproducible dynamic conversion of hyperpolarized [1-¹³C]-pyruvate.

    Directory of Open Access Journals (Sweden)

    Christopher M Walker

    Full Text Available In vivo real time spectroscopic imaging of hyperpolarized ¹³C labeled metabolites shows substantial promise for the assessment of physiological processes that were previously inaccessible. However, reliable and reproducible methods of measurement are necessary to maximize the effectiveness of imaging biomarkers that may one day guide personalized care for diseases such as cancer. Animal models of human disease serve as poor reference standards due to the complexity, heterogeneity, and transient nature of advancing disease. In this study, we describe the reproducible conversion of hyperpolarized [1-¹³C]-pyruvate to [1-¹³C]-lactate using a novel synthetic enzyme phantom system. The rate of reaction can be controlled and tuned to mimic normal or pathologic conditions of varying degree. Variations observed in the use of this phantom compare favorably against within-group variations observed in recent animal studies. This novel phantom system provides crucial capabilities as a reference standard for the optimization, comparison, and certification of quantitative imaging strategies for hyperpolarized tracers.

  19. Hyperpolarized Amino Acid Derivatives as Multivalent Magnetic Resonance pH Sensor Molecules.

    Science.gov (United States)

    Hundshammer, Christian; Düwel, Stephan; Ruseckas, David; Topping, Geoffrey; Dzien, Piotr; Müller, Christoph; Feuerecker, Benedikt; Hövener, Jan B; Haase, Axel; Schwaiger, Markus; Glaser, Steffen J; Schilling, Franz

    2018-02-15

    pH is a tightly regulated physiological parameter that is often altered in diseased states like cancer. The development of biosensors that can be used to non-invasively image pH with hyperpolarized (HP) magnetic resonance spectroscopic imaging has therefore recently gained tremendous interest. However, most of the known HP-sensors have only individually and not comprehensively been analyzed for their biocompatibility, their pH sensitivity under physiological conditions, and the effects of chemical derivatization on their logarithmic acid dissociation constant (p K a ). Proteinogenic amino acids are biocompatible, can be hyperpolarized and have at least two pH sensitive moieties. However, they do not exhibit a pH sensitivity in the physiologically relevant pH range. Here, we developed a systematic approach to tailor the p K a of molecules using modifications of carbon chain length and derivatization rendering these molecules interesting for pH biosensing. Notably, we identified several derivatives such as [1- 13 C]serine amide and [1- 13 C]-2,3-diaminopropionic acid as novel pH sensors. They bear several spin-1/2 nuclei ( 13 C, 15 N, 31 P) with high sensitivity up to 4.8 ppm/pH and we show that 13 C spins can be hyperpolarized with dissolution dynamic polarization (DNP). Our findings elucidate the molecular mechanisms of chemical shift pH sensors that might help to design tailored probes for specific pH in vivo imaging applications.

  20. Biochemical and structural analysis of the hyperpolarization-activated K(+) channel MVP.

    Science.gov (United States)

    Randich, Amelia M; Cuello, Luis G; Wanderling, Sherry S; Perozo, Eduardo

    2014-03-18

    In contrast to the majority of voltage-gated ion channels, hyperpolarization-activated channels remain closed at depolarizing potentials and are activated at hyperpolarizing potentials. The basis for this reverse polarity is thought to be a result of differences in the way the voltage-sensing domain (VSD) couples to the pore domain. In the absence of structural data, the molecular mechanism of this reverse polarity coupling remains poorly characterized. Here we report the characterization of the structure and local dynamics of the closed activation gate (lower S6 region) of MVP, a hyperpolarization-activated potassium channel from Methanococcus jannaschii, by electron paramagnetic resonance (EPR) spectroscopy. We show that a codon-optimized version of MVP has high expression levels in Escherichia coli, is purified as a stable tetramer, and exhibits expected voltage-dependent activity when reconstituted in liposomes. EPR analysis of the mid to lower S6 region revealed positions exhibiting strong spin-spin coupling, indicating that the activation gate of MVP is closed at 0 mV. A comparison of local environmental parameters along the activation gate for MVP and KcsA indicates that MVP adopts a different closed conformation. These structural details set the stage for future evaluations of reverse electromechanical coupling in MVP.

  1. Biochemical and Structural Analysis of the Hyperpolarization-Activated K+ Channel MVP

    Science.gov (United States)

    2015-01-01

    In contrast to the majority of voltage-gated ion channels, hyperpolarization-activated channels remain closed at depolarizing potentials and are activated at hyperpolarizing potentials. The basis for this reverse polarity is thought to be a result of differences in the way the voltage-sensing domain (VSD) couples to the pore domain. In the absence of structural data, the molecular mechanism of this reverse polarity coupling remains poorly characterized. Here we report the characterization of the structure and local dynamics of the closed activation gate (lower S6 region) of MVP, a hyperpolarization-activated potassium channel from Methanococcus jannaschii, by electron paramagnetic resonance (EPR) spectroscopy. We show that a codon-optimized version of MVP has high expression levels in Escherichia coli, is purified as a stable tetramer, and exhibits expected voltage-dependent activity when reconstituted in liposomes. EPR analysis of the mid to lower S6 region revealed positions exhibiting strong spin–spin coupling, indicating that the activation gate of MVP is closed at 0 mV. A comparison of local environmental parameters along the activation gate for MVP and KcsA indicates that MVP adopts a different closed conformation. These structural details set the stage for future evaluations of reverse electromechanical coupling in MVP. PMID:24490868

  2. A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone.

    Science.gov (United States)

    Song, Ok-Ryul; Kim, Han-Byul; Jouny, Samuel; Ricard, Isabelle; Vandeputte, Alexandre; Deboosere, Nathalie; Marion, Estelle; Queval, Christophe J; Lesport, Pierre; Bourinet, Emmanuel; Henrion, Daniel; Oh, Seog Bae; Lebon, Guillaume; Sandoz, Guillaume; Yeramian, Edouard; Marsollier, Laurent; Brodin, Priscille

    2017-07-18

    Mycolactone, a polyketide molecule produced by Mycobacterium ulcerans , is the etiological agent of Buruli ulcer. This lipid toxin is endowed with pleiotropic effects, presents cytotoxic effects at high doses, and notably plays a pivotal role in host response upon colonization by the bacillus. Most remarkably, mycolactone displays intriguing analgesic capabilities: the toxin suppresses or alleviates the pain of the skin lesions it inflicts. We demonstrated that the analgesic capability of mycolactone was not attributable to nerve damage, but instead resulted from the triggering of a cellular pathway targeting AT₂ receptors (angiotensin II type 2 receptors; AT₂R), and leading to potassium-dependent hyperpolarization. This demonstration paves the way to new nature-inspired analgesic protocols. In this direction, we assess here the hyperpolarizing properties of mycolactone on nociceptive neurons. We developed a dedicated medium-throughput assay based on membrane potential changes, and visualized by confocal microscopy of bis-oxonol-loaded Dorsal Root Ganglion (DRG) neurons. We demonstrate that mycolactone at non-cytotoxic doses triggers the hyperpolarization of DRG neurons through AT₂R, with this action being not affected by known ligands of AT₂R. This result points towards novel AT₂R-dependent signaling pathways in DRG neurons underlying the analgesic effect of mycolactone, with the perspective for the development of new types of nature-inspired analgesics.

  3. Acute hypertensive stress imaged by cardiac hyperpolarized [1-C]pyruvate magnetic resonance

    DEFF Research Database (Denmark)

    Tougaard, Rasmus Stilling; Hansen, Esben Søvsø Szocska; Laustsen, Christoffer

    2018-01-01

    PURPOSE: Deranged metabolism is now recognized as a key causal factor in a variety of heart diseases, and is being studied extensively. However, invasive methods may alter metabolism, and conventional imaging techniques measure tracer uptake but not downstream metabolism. These challenges may...... be overcome by hyperpolarized MR, a noninvasive technique currently crossing the threshold into human trials. The aim of this study was to image metabolic changes in the heart in response to endogastric glucose bolus and to acute hypertension. METHODS: Five postprandial pigs were scanned with hyperpolarized.......008) and ejection fraction decreased from 54 ± 2% to 47 ± 6% (P = 0.03) The hemodynamic changes were accompanied by increases in the hyperpolarized [1-13C]pyruvate MR derived ratios of lactate/alanine (from 0.58 ± 0.13 to 0.78 ± 0.06, P = 0.03) and bicarbonate/alanine (from 0.55 ± 0.12 to 0.91 ± 0.14, P = 0...

  4. Echo-planar MR imaging of dissolved hyperpolarized 129Xe. Potential for M angiography

    International Nuclear Information System (INIS)

    Maansson, S.

    2002-01-01

    Purpose: The feasibility of hyperpolarized 129 Xe for fast MR angiography (MRA) was evaluated using the echo-planar imaging (EPI) technique. Material and Methods: Hyperpolarized Xe gas was dissolved in ethanol; a carrier agent with high solubility for Xe (Ostwald solubility coefficient 2.5) and long relaxation times. The dissolved Xe was injected as a bolus into a flow phantom where the mean flow velocity was 15 cm/s. Ultrafast EPI images with 44 ms scan time were acquired of the flowing bolus and the signal-to-noise ratios (SNR) were measured. Results: The relaxation times of hyperpolarized Xe in ethanol were measured to T1=160±11 s and T2 ≅ 20 s. The resulting images of the flowing liquid were of reasonable quality and had an SNR of about 70. Conclusion: Based on the SNR of the obtained Xe EPI images; it was estimated that rapid in vivo MRA with 129 Xe may be feasible; provided that an efficient; biologically acceptable carrier for Xe can be found and polarization levels of more than 25% can be achieved in isotopically enriched 129 Xe

  5. Process for recovering xenon from radioactive gaseous wastes

    International Nuclear Information System (INIS)

    Kishimoto, Tsuneo.

    1980-01-01

    Purpose: To recover pure xenon economically and efficiently by amply removing radioactive krypton mixed in xenon without changing the rectifying capacity of an xenon rectifying system itself. Method: Xe containing radioactive Kr(Kr-85) is rectified to reduce the concentration of radioactive Kr. Thereafter, non-radioactive Kr or Ar is added to Xe and further the rectification is carried out. The raw material Xe from the Xe adsorption system of, for example, a radioactive gaseous waste disposal system is cooled to about 100 0 C by a heat-exchanger and thereafter supplied to a rectifying tower to carry out normal rectification of Xe thereby to reduce the concentration of Kr contained in Xe at the tower bottom to the rectification limit concentration. Then, non-radioactive Kr is supplied via a precooler to the tower bottom to continue the rectification, thus the Xe fractions at the tower bottom, in which the concentration of radioactive Kr is reduced, being compressed and recovered. (Kamimura, M.)

  6. NMR investigations of surfaces and interfaces using spin-polarized xenon

    International Nuclear Information System (INIS)

    Gaede, H.C.; Lawrence Berkeley Lab., CA

    1995-07-01

    129 Xe NMR is potentially useful for the investigation of material surfaces, but has been limited to high surface area samples in which sufficient xenon can be loaded to achieve acceptable signal to noise ratios. In Chapter 2 conventional 129 Xe NMR is used to study a high surface area polymer, a catalyst, and a confined liquid crystal to determine the topology of these systems. Further information about the spatial proximity of different sites of the catalyst and liquid crystal systems is determined through two dimensional exchange NMR in Chapter 3. Lower surface area systems may be investigated with spin-polarized xenon, which may be achieved through optical pumping and spin exchange. Optically polarized xenon can be up to 10 5 times more sensitive than thermally polarized xenon. In Chapter 4 highly polarized xenon is used to examine the surface of poly(acrylonitrile) and the formation of xenon clathrate hydrates. An attractive use of polarized xenon is as a magnetization source in cross polarization experiments. Cross polarization from adsorbed polarized xenon may allow detection of surface nuclei with drastic enhancements. A non-selective low field thermal mixing technique is used to enhance the 13 C signal of CO 2 of xenon occluded in solid CO 2 by a factor of 200. High-field cross polarization from xenon to proton on the surface of high surface area polymers has enabled signal enhancements of ∼1,000. These studies, together with investigations of the efficiency of the cross polarization process from polarized xenon, are discussed in Chapter 5. Another use of polarized xenon is as an imaging contrast agent in systems that are not compatible with traditional contrast agents. The resolution attainable with this method is determined through images of structured phantoms in Chapter 6

  7. Lambda-guided calculation method (LGC method) for xenon/CT CBF

    Energy Technology Data Exchange (ETDEWEB)

    Sase, Shigeru [Anzai Medical Co., Ltd., Tokyo (Japan); Honda, Mitsuru; Kushida, Tsuyoshi; Seiki, Yoshikatsu; Machida, Keiichi; Shibata, Iekado [Toho Univ., Tokyo (Japan). School of Medicine

    2001-12-01

    A quantitative CBF calculation method for xenon/CT was developed by logically estimating time-course change rate (rate constant) of arterial xenon concentration from that of end-tidal xenon concentration. A single factor ({gamma}) was introduced to correlate the end-tidal rate constant (Ke) with the arterial rate constant (Ka) in a simplified equation. This factor ({gamma}) is thought to reflect the diffusing capacity of the lung for xenon. When an appropriate value is given to {gamma}, it is possible to calculate the arterial rate constant (Calculated Ka) from Ke. To determine {gamma} for each xenon/CT CBF examination, a procedure was established which utilizes the characteristics of white matter lambda; lambda refers to xenon brain-blood partition coefficient. Xenon/CT studies were performed on four healthy volunteers. Hemispheric CBF values (47.0{+-}9.0 ml/100 g/min) with use of Calculated Ka were close to the reported normative values. For a 27-year-old healthy man, the rate constant for the common carotid artery was successfully measured and nearly equal to Calculated Ka. The authors conclude the method proposed in this work, lambda-guided calculation method, could make xenon/CT CBF substantially reliable and quantitative by effective use of end-tidal xenon. (author)

  8. Lambda-guided calculation method (LGC method) for xenon/CT CBF

    International Nuclear Information System (INIS)

    Sase, Shigeru; Honda, Mitsuru; Kushida, Tsuyoshi; Seiki, Yoshikatsu; Machida, Keiichi; Shibata, Iekado

    2001-01-01

    A quantitative CBF calculation method for xenon/CT was developed by logically estimating time-course change rate (rate constant) of arterial xenon concentration from that of end-tidal xenon concentration. A single factor (γ) was introduced to correlate the end-tidal rate constant (Ke) with the arterial rate constant (Ka) in a simplified equation. This factor (γ) is thought to reflect the diffusing capacity of the lung for xenon. When an appropriate value is given to γ, it is possible to calculate the arterial rate constant (Calculated Ka) from Ke. To determine γ for each xenon/CT CBF examination, a procedure was established which utilizes the characteristics of white matter lambda; lambda refers to xenon brain-blood partition coefficient. Xenon/CT studies were performed on four healthy volunteers. Hemispheric CBF values (47.0±9.0 ml/100 g/min) with use of Calculated Ka were close to the reported normative values. For a 27-year-old healthy man, the rate constant for the common carotid artery was successfully measured and nearly equal to Calculated Ka. The authors conclude the method proposed in this work, lambda-guided calculation method, could make xenon/CT CBF substantially reliable and quantitative by effective use of end-tidal xenon. (author)

  9. Multi-Ton Argon and Xenon

    Energy Technology Data Exchange (ETDEWEB)

    Alarcon, Ricardo; Balascuta, Septimiu; Alton, Drew; Aprile, Elena; Giboni, Karl-Ludwig; Haruyama, Tom; Lang, Rafael; Melgarejo, Antonio Jesus; Ni, Kaixuan; Plante, Guillaume; Choi, Bin [et al.

    2009-01-01

    There is a wide range of astronomical evidence that the visible stars and gas in all galaxies, including our own, are immersed in a much larger cloud of non-luminous matter, typically an order of magnitude greater in total mass. The existence of this ''dark matter'' is consistent with evidence from large-scale galaxy surveys and microwave background measurements, indicating that the majority of matter in the universe is non-baryonic. The nature of this non-baryonic component is still totally unknown, and the resolution of the ''dark matter puzzle'' is of fundamental importance to cosmology, astrophysics, and elementary particle physics. A leading explanation, motivated by supersymmetry theory, is the existence of as yet undiscovered Weakly Interacting Massive Particles (WIMPs), formed in the early universe and subsequently clustered in association with normal matter. WIMPs could, in principle, be detected in terrestrial experiments by their collisions with ordinary nuclei, giving observable low energy (< 100 keV) nuclear recoils. The predicted low collision rates require ultra-low background detectors with large (0.1-10 ton) target masses, located in deep underground sites to eliminate neutron background from cosmic ray muons. The establishment of the Deep Underground Science and Engineering Laboratory for large-scale experiments of this type would strengthen the current leadership of US researchers in this and other particle astrophysics areas. We propose to detect nuclear recoils by scintillation and ionization in ton-scale liquid noble gas targets, using techniques already proven in experiments at the 0.01-0.1 ton level. The experimental challenge is to identify these events in the presence of background events from gammas, neutrons, and alphas.

  10. Knowledge base expert system control of spatial xenon oscillations in pressurized water reactors

    International Nuclear Information System (INIS)

    Alten, S.

    1992-01-01

    Nuclear reactor operators are required to pay special attention to spatial xenon oscillations during the load-follow operation of pressurized water reactors. They are expected to observe the axial offset of the core, and to estimate the correct time and amount of necessary control action based on heuristic rules given in axial xenon oscillations are knowledge intensive, and heuristic in nature. An expert system, ACES (Axial offset Control using Expert Systems) is developed to implement a heuristic constant axial offset control procedure to aid reactor operators in increasing the plant reliability by reducing the human error component of the failure probability. ACES is written in a production system language, OPS5, based on the forward chaining algorithm. It samples reactor data with a certain time interval in terms of measurable parameters, such as the power, period, and the axial offset of the core. It then processes the core status utilizing a set of equations which are used in a back of the envelope calculations by domain experts. Heuristic rules of ACES identify the control variable to be used among the full and part length control rods and boron concentration, while a knowledge base is used to determine the amount of control. ACES is designed as a set of generic rules to avoid reducing the system into a set of patterns. Instead ACES evaluates the system, determines the necessary corrective actions in terms of reactivity insertion, and provides this reactivity insertion using the control variables. The amount of control action is determined using a knowledge base which consists of the differential rod worth curves, and the boron reactivity worth of a given reactor. Having the reactor dependent parameters in its knowledge base, ACES is applicable to an arbitrary reactor for axial offset control purposes

  11. Mitigation of {sup 222}Rn induced background in the XENON1T dark matter experiment

    Energy Technology Data Exchange (ETDEWEB)

    Bruenner, Stefan A.

    2017-07-05

    {sup 222}Rn is a major source of background in many rare-event experiments such as the XENON1T dark matter search. The noble gas radon is created by radioactive decay inside all detector materials and emanates into the sensitive liquid xenon target disabling any detector shielding. Subsequent beta-decays of radon progenies are the dominant source of background in the XENON1T experiment. In order to mitigate radon induced background the detector's construction materials have been selected according to dedicated {sup 222}Rn emanation measurements. In the first part of this thesis, we summarize the results of the XENON1T radon screening campaign and present the measurement of the integral radon emanation rate of the fully assembled detector. The development of a radon removal system which continuously purifies the liquid xenon target from the emanated radon is the topic of the second part of this thesis. In order to demonstrate the suitability of cryogenic distillation as a technique to separate radon from xenon, we developed an experimental setup to measure the depletion of radon in xenon boil-off gas after a single distillation step. In the last part of the thesis, we demonstrate the operation of a radon removal system for the XENON100 experiment. For this first test employing a running dark matter detector, we integrated a multiple stage, cryogenic distillation column in the XENON100 gas purification loop. From the evolution of the radon concentration in XENON100, we investigate the distillation column's radon removal capability and discuss the design and application of a radon removal system for XENON1T and the upcoming XENONnT experiment.

  12. Anomalous xenon in zone 13 Okelobondo

    International Nuclear Information System (INIS)

    Meshik, A.P.; Kehm, K.; Hohenberg, C.M.

    2000-01-01

    In situ laser extraction techniques were applied for the study of heavy noble gases in a polished section of Zone 13 from the natural nuclear reactor in Okelobondo. Three main mineral phases were identified in this polished section using SEM-EDX. The Xe and Kr isotopic structures were determined by multiple measurements in each of these phases. Twenty-four isotopic analyses of the gases extracted from two different U-rich phases revealed nearly normal fission spectra. All 9 analyses of a U-free phase, consisting mainly of alumophosphates, demonstrated an unusual isotopic composition ( 136 Xe/ 134 Xe/ 132 Xe/ 131 Xe/ 130 Xe 129 Xe/ 128 Xe = 1/1.25/1.73/0.89/0.0045/0.274/0) with concentrations ranging up to 10 -2 cm 3 STP/g. This is the highest Xe concentration ever measured in a natural material. Kr was also anomalous, although to a lesser extent. These results confirm the presence of Chemical Fractionation of Fission Xe (CFF-Xe) in the Okelobondo alumophosphates. CFF-Xe is a decay product of intermediate fission fragments that have migrated out of the U-rich host phases into adjacent U-free minerals. The CFF-Xe spectra in the alumophosphates are also accompanied by 130 Xe excesses, which are attributed to neutron capture on fissiogenic 129 I that apparently migrated out of the nearby U-rich minerals. The 130 Xe/ 129 Xe ratio allows one to estimate the thermal equivalent neutron dose of 1.1 x 10 21 n/cm 2 . The presence of an unknown fission component remarkably similar in composition to CFF-Xe can be inferred from the atmospheric and terrestrial data. This leads one to the hypothesis that the CFF process has operated on a global scale on the Earth

  13. Nuclear magnetic resonance studies of quadrupolar nuclei and dipolar field effects

    International Nuclear Information System (INIS)

    Urban, Jeffry Todd

    2004-01-01

    module for the recently developed NMR remote detection experiment. The feasibility of using hyperpolarized xenon-129 gas as a sensor is discussed. This work also reports the use of an optical atomic magnetometer to detect the nuclear magnetization of Xe-129 gas, which has potential applicability as a detection module for NMR remote detection experiments

  14. Nuclear magnetic resonance studies of quadrupolar nuclei and dipolar field effects

    Energy Technology Data Exchange (ETDEWEB)

    Urban, Jeffry Todd [Univ. of California, Berkeley, CA (United States)

    2004-01-01

    encoding module for the recently developed NMR remote detection experiment. The feasibility of using hyperpolarized xenon-129 gas as a sensor is discussed. This work also reports the use of an optical atomic magnetometer to detect the nuclear magnetization of Xe-129 gas, which has potential applicability as a detection module for NMR remote detection experiments.

  15. Calculation of xenon-oscillations in the HPLWR

    International Nuclear Information System (INIS)

    Reiss, T.; Feher, S.; Czifrus, Sz.

    2009-01-01

    The European version of the Supercritical Water Cooled Reactor (SCWR) is being developed under the name High Performance Light Water Reactor (HPLWR). In the most recent design, a three-pass core is foreseen with a heat-up of the coolant (supercritical pressure water) from 280degC to 500degC. Due to the operating pressure of 25 MPa, there is no phase change in the core but the density drop of the coolant can be as high as one order of magnitude. This results in a system which is sensitive to local temperature, power and density oscillations. This attribute is enhanced by the pseudocritical transformation of supercritical pressure water. Due to the relatively large dimensions of the core, xenon-oscillations are probable. The characteristic time of this process is several hours, thus a coupled quasi-stationary neutronics-thermohydraulics (CQNT) code completed with the xenon poisoning differential equations (XPDE) can predict the extent of xenon-oscillations. A program system is being developed at the Budapest University of Technology which is capable to perform full core CQNT calculations including the XPDE. The program system is designed to calculate one-pass (which was the first core proposal for HPLWRs, today called PWR-SC) and three-pass cores. The CQNT code is made up of an MCNP part (neutronics part) and of a thermohydraulics part developed at our Institute. Since full core MCNP calculations are very time consuming, upon symmetry considerations only one eighth of the core is modelled. On the other hand, this approach of modelling momentarily limits the phenomena which can be studied to axial oscillations. (author)

  16. Heat capacity of xenon adsorbed in nanobundle grooves

    International Nuclear Information System (INIS)

    Chishko, K.A.; Sokolova, E.S.

    2016-01-01

    A model of one-dimensional real gas under external transverse force field is applied to interpret the experimentally observed thermodynamical properties of xenon deposited into groves on the surface of carbon nanobundles. This non-ideal gas model with pair interaction is not quite adequate to describe the dense adsorbates (especially at low temperature limit), but it makes possible to take into account easily the particle exchange between 1D adsorbate and 3D atmosphere which becomes an essential factor since intermediate (for xenon - of order 35 K) up to high (approx 100 K) temperatures. In this paper we treat the 1D real gas with only Lennard-Jones pair interaction, but at presence of exact equilibrium conditions on the atom numbers between low-dimensional adsorbate and three-dimensional atmosphere of the experimental cell. The low-temperature branch of the heat capacity has been fitted separately within the elastic atomic chain model to get the best agreement between theory and experiment in as wide as possible region just from zero temperature. The gas approximation is introduced from the temperatures where the chain heat capacity tends definitely to 1D equipartition law. In this case the principal parameters for both models can be chosen in such a way that the heat capacity C(T) of the chain goes continuously into the corresponding curve of the gas approximation. So, it seems to be expected that adequate interpretation for temperature dependences of the atomic adsorbate heat capacity can be obtained through a reasonable combination of 1D gas and phonon approaches. The principal parameters of the gas approximation (such a desorption energy) found from the fitting between theory and experiment for xenon heat capacity are in good agreement with corresponding data known in literature.

  17. Determination of atmospheric concentrations of xenon radioisotopes. Progress report

    International Nuclear Information System (INIS)

    Abel, K.H.; Panisko, M.E.; Hensley, W.K.; Bowyer, T.W.; Perkins, R.W.

    1995-07-01

    Determination of radioactive xenon concentrations in the atmosphere over a two year period has been performed as part of a research program to develop real-time measurement capabilities. The initial measurements were made to develop, prove, and validate the authors technical approach, while the longer-term measurements are being undertaken to establish natural background concentrations and variability with time. The results reported were made using noble gas fraction (typically 90% Kr and 10% Xe by weight) gas samples obtained from a commercial air-reduction plant in the northeastern US over a two-year interval beginning in the fall of 1993. The concentrated gas samples were typically obtained during a 6--8 hour interval at the commercial reduction plant and were shipped overnight to their laboratory. Analysis was typically completed approximately 24 hours after sampling. The analytical separation process typically took approximately 6 hours and gamma-ray spectrometric measurements were conducted for intervals ranging from 3 to 16 hours. The technical approach involved removal of potentially interfering radon daughter radionuclides using a molecular sieve at room temperature, followed by cryogenic concentration of noble gases using a chilled (-76 C) activated carbon molecular sieve. During initial measurements both molecular sieve materials were contained in 30 foot x 1/4 inch gas chromatography columns for analytical separations. Krypton was separated from Xenon during the analytical procedure by warming the activated carbon molecular sieve to room temperature after initial noble gas concentration and actively pumping it away. Xenon-133 adsorbed to the activated charcoal molecular sieve was then quantified via its 81 keV gamma-ray using initially a p-type intrinsic germanium detector and later a higher efficiency (64% relative to a 3 inch x 3 inch sodium iodide) n-type intrinsic germanium detector

  18. Effect of capacitor loss on discharging characteristics of xenon flash lamp

    International Nuclear Information System (INIS)

    Zhang Chu; Lin Dejiang; Xu Chunmei; Shen Hongbin; Chen Xiaohan

    2012-01-01

    The effect of storage capacitor's loss on the discharging characteristics of the xenon flash lamp was studied, and the xenon flash lamp discharging circuit was analyzed and improved. The capacitor can be equivalent to a series of an ideal capacitor and loss resistance. The improved formula of the xenon lamp discharging characteristics was given when actual capacitance loss is not zero, and the xenon lamp discharging current and discharging power are calculated and analyzed in detail with the increase of the capacitor loss. The results show that the increase of loss will lead to the decrease of xenon lamp discharging current and peak power and the xenon lamp flash time, and influence laser pumping efficiency. The loss will also lead to the capacitor inverse charging in LC discharging circuit; this will influence normal working of the capacitor and decrease the lift of the xenon lamp. The actual energy storage capacitor charging and discharging experiments show that the increase of capacitor loss will lead to the decrease of xenon lamp light-emitting waveform peak, shortening of the flash time and increase of the electrode sputter, thus verity, the reasonableness of theoretical analysis. In addition, the experiments show that environmental factors have very significant impact on the increase of the storage capacitor loss. (authors)

  19. Collision-induced light scattering in a thin xenon layer between graphite slabs - MD study.

    Science.gov (United States)

    Dawid, A; Górny, K; Wojcieszyk, D; Dendzik, Z; Gburski, Z

    2014-08-14

    The collision-induced light scattering many-body correlation functions and their spectra in thin xenon layer located between two parallel graphite slabs have been investigated by molecular dynamics computer simulations. The results have been obtained at three different distances (densities) between graphite slabs. Our simulations show the increased intensity of the interaction-induced light scattering spectra at low frequencies for xenon atoms in confined space, in comparison to the bulk xenon sample. Moreover, we show substantial dependence of the interaction-induced light scattering correlation functions of xenon on the distances between graphite slabs. The dynamics of xenon atoms in a confined space was also investigated by calculating the mean square displacement functions and related diffusion coefficients. The structural property of confined xenon layer was studied by calculating the density profile, perpendicular to the graphite slabs. Building of a fluid phase of xenon in the innermost part of the slot was observed. The nonlinear dependence of xenon diffusion coefficient on the separation distance between graphite slabs has been found. Copyright © 2014. Published by Elsevier B.V.

  20. Dynamic adsorption property of xenon on activated carbon and carbon molecular sieves

    International Nuclear Information System (INIS)

    Feng Shujuan; Zhou Guoqing; Jin Yuren; Zhou Chongyang

    2010-01-01

    In order to select well adsorptive xenon adsorbent, the dynamic adsorption property of xenon on activated carbon and carbon molecular sieves (CMS) was studied by measuring the xenon dynamic adsorption coefficient as a function velocity of gas, temperature, carrier gas, pressure and concentration of CO 2 . The results show that the highest value of xenon dynamic adsorption coefficient is on CMS1, and the second highest value is on CMS2; when the xenon concentration is less than 10 -5 mol/L or concentration of CO 2 is less than 5 x 10 -5 mol/L, the xenon dynamic adsorption coefficient nearly keeps constant at the specific experimental flow rate. Then the xenon dynamic adsorption coefficient would vary when it was mixed with different kind of carrier gas and become less at more than 5 x 10 -5 mol/L concentration of CO 2 . And the maximal effect factors are temperature and pressure. Therefore, the feasible measures to improve the xenon capability are to cool the adsorbent and increase adsorption pressure. (authors)

  1. Lowering the radioactivity of the photomultiplier tubes for the XENON1T dark matter experiment

    NARCIS (Netherlands)

    Aprile, E.; et al., [Unknown; Alfonsi, M.; Colijn, A.P.; Decowski, M.P.; Tiseni, A.; Tunnell, C.

    2015-01-01

    The low-background, VUV-sensitive 3-inch diameter photomultiplier tube R11410 has been developed by Hamamatsu for dark matter direct detection experiments using liquid xenon as the target material. We present the results from the joint effort between the XENON collaboration and the Hamamatsu company

  2. Xenon Acquisition Strategies for High-Power Electric Propulsion NASA Missions

    Science.gov (United States)

    Herman, Daniel A.; Unfried, Kenneth G.

    2015-01-01

    The benefits of high-power solar electric propulsion (SEP) for both NASA's human and science exploration missions combined with the technology investment from the Space Technology Mission Directorate have enabled the development of a 50kW-class SEP mission. NASA mission concepts developed, including the Asteroid Redirect Robotic Mission, and those proposed by contracted efforts for the 30kW-class demonstration have a range of xenon propellant loads from 100's of kg up to 10,000 kg. A xenon propellant load of 10 metric tons represents greater than 10% of the global annual production rate of xenon. A single procurement of this size with short-term delivery can disrupt the xenon market, driving up pricing, making the propellant costs for the mission prohibitive. This paper examines the status of the xenon industry worldwide, including historical xenon supply and pricing. The paper discusses approaches for acquiring on the order of 10 MT of xenon propellant considering realistic programmatic constraints to support potential near-term NASA missions. Finally, the paper will discuss acquisitions strategies for mission campaigns utilizing multiple high-power solar electric propulsion vehicles requiring 100's of metric tons of xenon over an extended period of time where a longer term acquisition approach could be implemented.

  3. Regional study of ventilation with inhaled xenon 133 in children

    International Nuclear Information System (INIS)

    Gaultier, C.; Mensch, B.; Gerbeaux, J.

    1975-01-01

    A regional exploration of pulmonary ventilation in a population of 104 infants and children by a study of distribution and washout of xenon 133 inhaled with rebreathing is carried out. The results are expressed by photographs (gamma-camera) and time-activity curves. The indications for regional exploration were oriented by the existence on the straight X-ray film of a localised ventilation disorder (a hyperlucent area or an opacity). This study permitted physiopathological analysis and guided endobronchial examinations. The functional results obtained, complete and explain other methods of exploration of lung function by spirography, ventilatory mechanics, transthoracic electrical measurements and study of lung perfusion with technetium 99m [fr

  4. Krypton and xenon in the atmosphere of Venus

    Science.gov (United States)

    Donahue, T. M.; Hoffman, J. H.; Hodges, R. R., Jr.

    1981-01-01

    The paper reports a determination by the Pioneer Venus large probe neutral mass spectrometer of upper limits to the concentration of krypton and xenon along with most of their isotopes in the atmosphere of Venus. The upper limit to the krypton mixing ratio is estimated at 47 ppb, with a very conservative estimate at 69 ppb. The probable upper limit to the sum of the mixing ratios of the isotopes Xe-128, Xe-129, Xe-130, Xe-131, and Xe-132 is 40 ppb by volume, with a very conservative upper limit three times this large.

  5. Study of regional lung function with xenon 133

    International Nuclear Information System (INIS)

    Devaux, D.; Wagner, R.; Germain, M.; Chardon, G.

    1975-01-01

    Exploration of regional lung function includes study of the closed circuit perfusion and ventilation respectively by injection and inhalation of xenon 133. The radiation is measured across the chest using 4 fixed scintillation counters, placed opposite the subject's back, 2 per lung field. Theoretical regional values using 15 normal young subjects are determined. Three cases justified the practical interest of this method. The percentage of variation for the parameters studied was about 10%. The method proved very useful for the clinician to whom it provides a numerical assessment of regional ventilation and perfusion [fr

  6. The adsorption of argon, krypton and xenon on activated charcoal

    International Nuclear Information System (INIS)

    Underhill, D.W.

    1996-01-01

    Charcoal adsorption beds are commonly used to remove radioactive noble gases from contaminated gas streams. The design of such beds requires the adsorption coefficient for the noble gas. Here an extension of the Dubinin-Radushkevich theory of adsorption is developed to correlate the effects of temperature, pressure, concentration, and carrier gas on the adsorption coefficients of krypton, xenon, and argon on activated carbon. This model is validated with previously published adsorption measurements. It accurately predicts the equilibrium adsorption coefficient at any temperature and pressure if the potential energies of adsorption, the micropore volume, and the van der Waals constants of the gases are known. 18 refs., 4 figs

  7. Hyperpolarization-activated current (In is reduced in hippocampal neurons from Gabra5-/- mice.

    Directory of Open Access Journals (Sweden)

    Robert P Bonin

    Full Text Available Changes in the expression of γ-aminobutyric acid type A (GABAA receptors can either drive or mediate homeostatic alterations in neuronal excitability. A homeostatic relationship between α5 subunit-containing GABAA (α5GABAA receptors that generate a tonic inhibitory conductance, and HCN channels that generate a hyperpolarization-activated cation current (Ih was recently described for cortical neurons, where a reduction in Ih was accompanied by a reciprocal increase in the expression of α5GABAA receptors resulting in the preservation of dendritosomatic synaptic function. Here, we report that in mice that lack the α5 subunit gene (Gabra5-/-, cultured embryonic hippocampal pyramidal neurons and ex vivo CA1 hippocampal neurons unexpectedly exhibited a decrease in Ih current density (by 40% and 28%, respectively, compared with neurons from wild-type (WT mice. The resting membrane potential and membrane hyperpolarization induced by blockade of Ih with ZD-7288 were similar in cultured WT and Gabra5-/- neurons. In contrast, membrane hyperpolarization measured after a train of action potentials was lower in Gabra5-/- neurons than in WT neurons. Also, membrane impedance measured in response to low frequency stimulation was greater in cultured Gabra5-/- neurons. Finally, the expression of HCN1 protein that generates Ih was reduced by 41% in the hippocampus of Gabra5-/- mice. These data indicate that loss of a tonic GABAergic inhibitory conductance was followed by a compensatory reduction in Ih. The results further suggest that the maintenance of resting membrane potential is preferentially maintained in mature and immature hippocampal neurons through the homeostatic co-regulation of structurally and biophysically distinct cation and anion channels.

  8. Hyperpolarized Amino Acid Derivatives as Multivalent Magnetic Resonance pH Sensor Molecules

    Directory of Open Access Journals (Sweden)

    Christian Hundshammer

    2018-02-01

    Full Text Available pH is a tightly regulated physiological parameter that is often altered in diseased states like cancer. The development of biosensors that can be used to non-invasively image pH with hyperpolarized (HP magnetic resonance spectroscopic imaging has therefore recently gained tremendous interest. However, most of the known HP-sensors have only individually and not comprehensively been analyzed for their biocompatibility, their pH sensitivity under physiological conditions, and the effects of chemical derivatization on their logarithmic acid dissociation constant (pKa. Proteinogenic amino acids are biocompatible, can be hyperpolarized and have at least two pH sensitive moieties. However, they do not exhibit a pH sensitivity in the physiologically relevant pH range. Here, we developed a systematic approach to tailor the pKa of molecules using modifications of carbon chain length and derivatization rendering these molecules interesting for pH biosensing. Notably, we identified several derivatives such as [1-13C]serine amide and [1-13C]-2,3-diaminopropionic acid as novel pH sensors. They bear several spin-1/2 nuclei (13C, 15N, 31P with high sensitivity up to 4.8 ppm/pH and we show that 13C spins can be hyperpolarized with dissolution dynamic polarization (DNP. Our findings elucidate the molecular mechanisms of chemical shift pH sensors that might help to design tailored probes for specific pH in vivo imaging applications.

  9. Ovariectomy increases the participation of hyperpolarizing mechanisms in the relaxation of rat aorta.

    Directory of Open Access Journals (Sweden)

    Ana Sagredo

    Full Text Available This study examines the downstream NO release pathway and the contribution of different vasodilator mediators in the acetylcholine-induced response in rat aorta 5-months after the loss of ovarian function. Aortic segments from ovariectomized and control female Sprague-Dawley rats were used to measure: the levels of superoxide anion, the superoxide dismutases (SODs activity, the cGMP formation, the cGMP-dependent protein kinase (PKG activity and the involvement of NO, cGMP, hydrogen peroxide and hyperpolarizing mechanisms in the ACh-induced relaxation. The results showed that ovariectomy did not alter ACh-induced relaxation; incubation with L-NAME, a NO synthase inhibitor, decreased the ACh-induced response to a lesser extent in aorta from ovariectomized than from control rats, while ODQ, a guanylate cyclase inhibitor, decreased that response to a similar extent; the blockade of hyperpolarizing mechanisms, by precontracting arteries with KCl, decreased the ACh-induced response to a greater extent in aortas from ovariectomized than those from control rats; catalase, that decomposes hydrogen peroxide, decreased the ACh-induced response only in aorta from ovariectomized rats. In addition, ovariectomy increased superoxide anion levels and SODs activity, decreased cGMP formation and increased PKG activity. Despite the increased superoxide anion and decreased cGMP in aorta from ovariectomized rats, ACh-induced relaxation is maintained by the existence of hyperpolarizing mechanisms in which hydrogen peroxide participates. The greater contribution of hydrogen peroxide in ACh-induced relaxation is due to increased SOD activity, in an attempt to compensate for increased superoxide anion formation. Increased PKG activity could represent a redundant mechanism to ensure vasodilator function in the aorta of ovariectomized rats.

  10. Automatic control logics to eliminate xenon oscillation based on Axial Offsets Trajectory Method

    International Nuclear Information System (INIS)

    Shimazu, Yoichiro

    1996-01-01

    We have proposed Axial Offsets (AO) Trajectory Method for xenon oscillation control in pressurized water reactors. The features of this method are described as such that it can clearly give necessary control operations to eliminate xenon oscillations. It is expected that using the features automatic control logics for xenon oscillations can be simple and be realized easily. We investigated automatic control logics. The AO Trajectory Method could realize a very simple logic only for eliminating xenon oscillations. However it was necessary to give another considerations to eliminate the xenon oscillation with a given axial power distribution. The other control logic based on the modern control theory was also studied for comparison of the control performance of the new control logic. As the results, it is presented that the automatic control logics based on the AO Trajectory Method are very simple and effective. (author)

  11. Scalability, Scintillation Readout and Charge Drift in a Kilogram Scale Solid Xenon Particle Detector

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, J. [Fermilab; Cease, H. [Fermilab; Jaskierny, W. F. [Fermilab; Markley, D. [Fermilab; Pahlka, R. B. [Fermilab; Balakishiyeva, D. [Florida U.; Saab, T. [Florida U.; Filipenko, M. [Erlangen - Nuremberg U., ECAP

    2014-10-23

    We report a demonstration of the scalability of optically transparent xenon in the solid phase for use as a particle detector above a kilogram scale. We employ a liquid nitrogen cooled cryostat combined with a xenon purification and chiller system to measure the scintillation light output and electron drift speed from both the solid and liquid phases of xenon. Scintillation light output from sealed radioactive sources is measured by a set of high quantum efficiency photomultiplier tubes suitable for cryogenic applications. We observed a reduced amount of photons in solid phase compared to that in liquid phase. We used a conventional time projection chamber system to measure the electron drift time in a kilogram of solid xenon and observed faster electron drift speed in the solid phase xenon compared to that in the liquid phase.

  12. Hyperpolarized 89Y NMR spectroscopic detection of yttrium ion and DOTA macrocyclic ligand complexation: pH dependence and Y-DOTA intermediates

    Science.gov (United States)

    Ferguson, Sarah; Kiswandhi, Andhika; Niedbalski, Peter; Parish, Christopher; Kovacs, Zoltan; Lumata, Lloyd

    Dissolution dynamic nuclear polarization (DNP) is a rapidly emerging physics technique used to enhance the signal strength in nuclear magnetic resonance (NMR) and imaging (MRI) experiments for nuclear spins such as yttrium-89 by >10,000-fold. One of the most common and stable MRI contrast agents used in the clinic is Gd-DOTA. In this work, we have investigated the binding of the yttrium and DOTA ligand as a model for complexation of Gd ion and DOTA ligand. The macrocyclic ligand DOTA is special because its complexation with lanthanide ions such as Gd3+ or Y3+ is highly pH dependent. Using this physics technology, we have tracked the complexation kinetics of hyperpolarized Y-triflate and DOTA ligand in real-time and detected the Y-DOTA intermediates. Different kinds of buffers were used (lactate, acetate, citrate, oxalate) and the pseudo-first order complexation kinetic calculations will be discussed. The authors would like to acknowledge the support by US Dept of Defense Award No. W81XWH-14-1-0048 and Robert A. Welch Foundation Grant No. AT-1877.

  13. Hyperpolarized 13C Urea Relaxation Mechanism Reveals Renal Changes in Diabetic Nephropathy

    DEFF Research Database (Denmark)

    Laustsen, Christoffer; Stokholm Nørlinger, Thomas; Christoffer Hansen, David

    2016-01-01

    Purpose: Our aim was to assess a novel 13C radial fast spin echo golden ratio single shot method for interrogating early renal changes in the diabetic kidney, using hyperpolarized (HP) [13C,15N2]urea as a T2 relaxation based contrast bio-probe. Methods: A novel HP 13C MR contrast experiment...... saturation level and the relaxation times were observed in the healthy controls. Conclusion: HP [13C,15N2]urea apparent T2 mapping may be a useful for interrogating local renal pO2 status and renal tissue alterations....

  14. Monitoring Cancer Response to Treatment with Hyperpolarized 13C MRS

    DEFF Research Database (Denmark)

    Eldirdiri, Abubakr

    , and the patient is exposed to ionizing radiation. The introduction of hyperpolarized 13C MRS has opened completely new possibilities to study the biochemical changes in disease processes. Numerous 13C-labeled compounds were proposed to interrogate various aspects of cancer cell metabolism. The aim of this study......Monitoring the cancer response to treatment, non-invasively, by medical imaging is a key element in the management of cancer. For patients undergoing treatment, it is crucial to determine responders from non-responders in order to guide treatment decisions. Currently, PET is the most widely used...

  15. Magnetic resonance butterfly coils: Design and application for hyperpolarized 13C studies

    DEFF Research Database (Denmark)

    Giovannetti, Giulio; Frijia, Francesca; Attanasio, Simona

    2013-01-01

    Hyperpolarized 13C magnetic resonance spectroscopy in pig models enables cardiac metabolism assessment and provides a powerful tool for heart physiology studies, although the low molar concentration of derivate metabolites gives rise to technological limitations in terms of data quality. The desi...... throughout the volume of interest for cardiac imaging in pig. Experimental SNR-vs-depth profiles, extracted from the [1-13C]acetate phantom chemical shift image (CSI), permitted to highlight the performance of the proposed coils configuration. © 2013 Elsevier Ltd. All rights reserved....

  16. Xenon oscillation control in large PWR using a characteristic ellipse trajectory drawn by three axial offsets

    International Nuclear Information System (INIS)

    Yoichiro, Shimazu

    2007-01-01

    We have proposed a very simple xenon oscillation control procedure based on a characteristic trajectory. The trajectory is drawn by three offsets of power distributions, namely, AOp, AOi and AOx. They are defined as the offset of axial power distribution, the offset of the power distribution under which the current iodine distribution is obtained as the equilibrium and that for xenon distribution, respectively. When these offsets are plotted on X-Y plane for (AOp-AOx, AOi-AOx) the trajectory shows a quite characteristic ellipse (or an elliptic spiral). It shows characteristics such that the center of the ellipse is at the origin, the gradient of the major axis is constant, direction of the trajectory progress is always anti-clock wise, plot goes around the ellipse during a cycle of the xenon oscillation and so on. This characteristic does not change even if the control rods are moved. When the plot is at the origin of the X-Y plane, no xenon oscillation exists. Using the characteristics of the ellipse the xenon oscillation can be eliminated by guiding the plot to the origin with control rod operation. This concept can be applied not only to the axial xenon oscillation but also to the radial xenon oscillation control. Conventionally, the trajectory is drawn based on the xenon dynamics using reactor parameters such as core averaged macroscopic fission cross section, xenon micro absorption cross section, fission yields of iodine and xenon, and so on together with the neutron flux signals. The accuracy is expected to be better. (authors)

  17. Hyperpolarized 13C MR imaging detects no lactate production in mutant IDH1 gliomas: Implications for diagnosis and response monitoring

    Directory of Open Access Journals (Sweden)

    Myriam M. Chaumeil

    2016-01-01

    Full Text Available Metabolic imaging of brain tumors using 13C Magnetic Resonance Spectroscopy (MRS of hyperpolarized [1-13C] pyruvate is a promising neuroimaging strategy which, after a decade of preclinical success in glioblastoma (GBM models, is now entering clinical trials in multiple centers. Typically, the presence of GBM has been associated with elevated hyperpolarized [1-13C] lactate produced from [1-13C] pyruvate, and response to therapy has been associated with a drop in hyperpolarized [1-13C] lactate. However, to date, lower grade gliomas had not been investigated using this approach. The most prevalent mutation in lower grade gliomas is the isocitrate dehydrogenase 1 (IDH1 mutation, which, in addition to initiating tumor development, also induces metabolic reprogramming. In particular, mutant IDH1 gliomas are associated with low levels of lactate dehydrogenase A (LDHA and monocarboxylate transporters 1 and 4 (MCT1, MCT4, three proteins involved in pyruvate metabolism to lactate. We therefore investigated the potential of 13C MRS of hyperpolarized [1-13C] pyruvate for detection of mutant IDH1 gliomas and for monitoring of their therapeutic response. We studied patient-derived mutant IDH1 glioma cells that underexpress LDHA, MCT1 and MCT4, and wild-type IDH1 GBM cells that express high levels of these proteins. Mutant IDH1 cells and tumors produced significantly less hyperpolarized [1-13C] lactate compared to GBM, consistent with their metabolic reprogramming. Furthermore, hyperpolarized [1-13C] lactate production was not affected by chemotherapeutic treatment with temozolomide (TMZ in mutant IDH1 tumors, in contrast to previous reports in GBM. Our results demonstrate the unusual metabolic imaging profile of mutant IDH1 gliomas, which, when combined with other clinically available imaging methods, could be used to detect the presence of the IDH1 mutation in vivo.

  18. Electron momentum spectroscopy of xenon: A detailed analysis

    International Nuclear Information System (INIS)

    Cook, J.P.D.; McCarthy, I.E.; Mitroy, J.; Weigold, E.

    1986-01-01

    Accurate measurements of the 1000-eV noncoplanar symmetric (e,2e) reaction on xenon are reported. Cross-section calculations are carried out with the use of both the plane-wave and distorted-wave impulse approximations. The distorted-wave impulse approximation accurately describes both the 5p -1 and 5s -1 angular correlations and their relative cross sections. It also describes accurately the 5p/sub 3/2/ -1 :5p/sub 1/2/ -1 branching ratios if Dirac-Fock target wave functions are used. The branching ratios show the inadequacy of Hartree-Fock wave functions for xenon. The plane-wave impulse-approximation overestimates the 5s -1 cross section relative to the 5p -1 and underestimates the cross section at large angles. The 5s -1 spectroscopic factors are assigned up to a separation energy of 45 eV, and the distorted-wave impulse-approximation calculation verifies that all the 5s -1 strength has been found. The spectroscopic factors for the 5s -1 manifold are obtained at 1000 and 1200 eV at a number of angles and are found to be independent of incident energy and ion recoil momentum. The spectroscopic factor for the lowest 5s -1 transition at 23.4 eV is 0.37 +- 0.01, whereas that for the ground-state 5p -1 transition is greater than or equal to 0.98

  19. First Axion Results from the XENON100 Experiment

    CERN Document Server

    Aprile, E.; Alfonsi, M.; Arisaka, K.; Arneodo, F.; Auger, M.; Balan, C.; Barrow, P.; Baudis, L.; Bauermeister, B.; Behrens, A.; Beltrame, P.; Bokeloh, K.; Brown, A.; Brown, E.; Bruenner, S.; Bruno, G.; Budnik, R.; Cardoso, J.M.R.; Colijn, A.P.; Contreras, H.; Cussonneau, J.P.; Decowski, M.P.; Duchovni, E.; Fattori, S.; Ferella, A.D.; Fulgione, W.; Gao, F.; Garbini, M.; Geis, C.; Goetzke, L.W.; Grignon, C.; Gross, E.; Hampel, W.; Itay, R.; Kaether, F.; Kessler, G.; Kish, A.; Landsman, H.; Lang, R.F.; Calloch, M. Le; Lellouch, D.; Levy, C.; Lindemann, S.; Lindner, M.; Lopes, J.A.M.; Lung, K.; Lyashenko, A.; Macmullin, S.; Marrodan Undagoitia, T.; Masbou, J.; Massoli, F.V.; Mayani Paras, D.; Melgarejo Fernandez, A. J.; Meng, Y.; Messina, M.; Miguez, B.; Molinario, A.; Murra, M.; Naganoma, J.; Oberlack, U.; Orrigo, S.E.A.; Pantic, E.; Persiani, R.; Piastra, F.; Pienaar, J.; Plante, G.; Priel, N.; Reichard, S.; Reuter, C.; Rizzo, A.; Rosendahl, S.; dos Santos, J. M. F.; Sartorelli, G.; Schindler, S.; Schreiner, J.; Schumann, M.; Scotto Lavina, L.; Selvi, M.; Shagin, P.; Simgen, H.; Teymourian, A.; Thers, D.; Tiseni, A.; Trinchero, G.; Vitells, O.; Wang, H.; Weber, M.; Weinheimer, C.

    2014-09-09

    We present the first results of searches for axions and axion-like-particles with the XENON100 experiment. The axion-electron coupling constant, $g_{Ae}$, has been tested by exploiting the axio-electric effect in liquid xenon. A profile likelihood analysis of 224.6 live days $\\times$ 34 kg exposure has shown no evidence for a signal. By rejecting $g_{Ae}$, larger than $7.7 \\times 10^{-12}$ (90% CL) in the solar axion search, we set the best limit to date on this coupling. In the frame of the DFSZ and KSVZ models, we exclude QCD axions heavier than 0.3 eV/c$^2$ and 80 eV/c$^2$, respectively. For axion-like-particles, under the assumption that they constitute the whole abundance of dark matter in our galaxy, we constrain $g_{Ae}$, to be lower than $1 \\times 10^{-12}$ (90% CL) for masses between 5 and 10 keV/c$^2$.

  20. Theoretical investigation of the secondary ionization in krypton and xenon

    International Nuclear Information System (INIS)

    Saffo, M.E.

    1986-01-01

    A theoretical investigation of the secondary ionization processes that responsible for the pre-breakdown ionization current growth in a uniform electric field was studied in krypton and xenon gases, especially at low values of E/P 0 which is corresponding to high values of pressure, since there are a number of possible secondary ionization processes. It is interesting to carry out a quantitative analysis for the generalized secondary ionization coefficient obtained previously by many workers in terms of the production of excited states and their diffusion to the cathode and their destruction rate in the gas body. From energy balance equation for the electrons in the discharge, the fractional percentage energy losses of ionization, excitation, and elastic collisions to the total energy gained by the electron from the field has been calculated for krypton and xenon, as a result of such calculations; the conclusion drawn is that at low values of E/P 0 the main energy loss of electrons are in excited collision. Therefore, we are adopting a theoretical calculation for W/α under the assumption that the photo-electron emission at the cathode is the predominated secondary ionization process. 14 tabs.; 12 figs.; 64 refs

  1. Interdiffusion of krypton and xenon in high-pressure helium

    International Nuclear Information System (INIS)

    Campana, R.J.; Jensen, D.D.; Epstein, B.D.; Hudson, R.G.; Baldwin, N.L.

    1980-01-01

    The interdiffusion of gaseous fission products in high-pressure helium is an important factor in the control of radioactivity in gas-cooled fast breeder reactors (GCFRs). As presently conceived, GCFRs use pressure-equalized and vented fuel in which fission gases released from the solid matrix oxide fuel are transported through the fuel rod interstices and internal fission product traps to the fuel assembly vents, where they are swept away to external traps and storage. Since the predominant transport process under steady-state operating conditions is interdiffusion of gaseous fission products in helium, the diffusion properties of krypton-helium and xenon-helium couples have been measured over the range of GCFR temperature and pressure conditions ( -1 ) and expected temperature dependence to the 1.66 power (Tsup(1.66)) at lower pressures and temperatures. Additional work is in progress to measure the behaviour of the krypton-helium and xenon-helium couples in GCFR fuel rod charcoal delay traps. (author)

  2. Experimental studies on ion mobility in xenon-trimethylamine mixtures

    Science.gov (United States)

    Trindade, A. M. F.; Encarnação, P. M. C. C.; Escada, J.; Cortez, A. F. V.; Neves, P. N. B.; Conde, C. A. N.; Borges, F. I. G. M.; Santos, F. P.

    2017-07-01

    In this paper we present experimental results for ion reduced mobilities (K0) in gaseous trimethylamine, TMA—(CH3)3N, and xenon-TMA mixtures for reduced electric fields E/N between 7.5 and 60 Td and in the pressure range from 0.5 to 10 Torr, at room temperature. Both in the mixtures and in pure TMA only one peak was observed in the time of arrival spectra, which is believed to be due to two TMA ions with similar mass, (CH3)3N+ (59 u) and (CH3)2CH2N+ (58 u), whose mobility is indistinguishable in our experimental system. The possibility of ion cluster formation is also discussed. In pure TMA, for the E/N range investigated, an average value of 0.56 cm2V-1s-1 was obtained for the reduced mobility of TMA ions. For the studied mixtures, it was observed that even a very small amount of gaseous TMA (~0.2%) in xenon leads to the production of the above referred TMA ions or clusters. The reduced mobility value of this ion or ions in Xe-TMA mixtures is higher than the value in pure TMA: around 0.8 cm2V-1s-1 for TMA concentrations from 0.2% to about 10%, decreasing for higher TMA percentages, eventually converging to the reduced mobility value in pure TMA.

  3. Stability of tetraphenyl butadiene thin films in liquid xenon

    International Nuclear Information System (INIS)

    Sanguino, P.; Balau, F.; Botelho do Rego, A.M.; Pereira, A.; Chepel, V.

    2016-01-01

    Tetraphenyl butadiene (TPB) is widely used in particle detectors as a wavelength shifter. In this work we studied the stability of TPB thin films when immersed in liquid xenon (LXe). The thin films were deposited on glass and quartz substrates by thermal evaporation. Morphological and chemical surface properties were monitored before and after immersion into LXe by scanning electron microscopy and X-ray photoelectron spectroscopy. No appreciable changes have been detected with these two methods. Grain size and surface chemical composition were found to be identical before and after submersion into LXe. However, the film thickness, measured via optical transmission in the ultraviolet–visible wavelength regions, decreased by 1.6 μg/cm 2 (24%) after immersion in LXe during 20 h. These results suggest the necessity of using a protective thin film over the Tetraphenyl butadiene when used as a wavelength shifter in LXe particle detectors. - Highlights: • Stability of tetraphenyl butadiene (TPB) thin films immersed in liquid xenon (LXe). • Thermally evaporated TPB thin films were immersed in LXe for 20 h. • Film morphology and chemical surface properties remained unchanged. • Surface density of the films decreased by 1.6 μg/cm 2 (24%) after immersion in LXe. • For using in LXe particle detectors, TPB films should be protected with a coating.

  4. Energy loading effects in the scaling of atomic xenon lasers

    International Nuclear Information System (INIS)

    Ohwa, M.; Kushner, M.J.

    1990-01-01

    The intrinsic power efficiency of the atomic xenon (5d → 6p) infrared (1.73--3.65 μm) laser is sensitive to the rate of pumping due to electron collision mixing of the laser levels. Long duration pumping at moderate power deposition may therefore result in higher energy efficiencies than pumping at higher powers. In this paper the authors examine the consequences of high energy deposition (100's J/1 atm) during long pumping pulses (100's μs) on the intrinsic power and energy efficiency and optimum power deposition of the atomic xenon laser. The dominant effect of high energy loading, gas heating, causes an increase in the electron density and therefore an increase in the electron collision mixing of the laser levels. The optimum power deposition for a given gas density therefore shifts to lower values with increasing gas temperature. For sufficiently long pumping pulses, nonuniform gas heating results in convection and rarification of highly pumped regions. The optimum power deposition therefore shifts to even lower values as the length of the pumping pulse increases. As a result, laser efficiency depends on the spatial distribution of power deposition as well as its magnitude

  5. Imaging regional metabolic changes in the ischemic rat heart in vivo using hyperpolarized(1-13C)Pyruvate

    DEFF Research Database (Denmark)

    Lauritzen, Mette Hauge; Magnusson, Peter; Laustsen, Christoffer

    2017-01-01

    in the in vivo rat heart in an open-chest model of ischemia reperfusion. Hyperpolarized MRI enables new possibilities for evaluating changes in cardiac metabolism noninvasively and in real time, which potentially could be used for research to evaluate new treatments and metabolic interventions for myocardial......We evaluated the use of hyperpolarized 13C magnetic resonance imaging (MRI) in an open-chest rat model of myocardial infarction to image regional changes in myocardial metabolism. In total, 10 rats were examined before and after 30 minutes of occlusion of the left anterior descending coronary...

  6. Transmit-Only/Receive-Only Radiofrequency System for Hyperpolarized 13C MRS Cardiac Metabolism Studies in Pigs

    DEFF Research Database (Denmark)

    Giovannetti, G.; Frijia, F.; Hartwig, V.

    2013-01-01

    Hyperpolarized 13C magnetic resonance spectroscopy in pig models enables metabolic activity mapping, providing a powerful tool for the study of the heart physiology, but requires the development of dedicated radiofrequency coils, capable of providing large field of view with high signal......-to-noise ratio (SNR) data. This work describes the simulations and the tests of a transmit-only (TX) volume coil/receive-only (RX) surface coil both designed for hyperpolarized studies of pig heart with a clinical 3T scanner. The coil characterization is performed by developing an SNR model for coil performance...

  7. Nuclear

    International Nuclear Information System (INIS)

    2014-01-01

    This document proposes a presentation and discussion of the main notions, issues, principles, or characteristics related to nuclear energy: radioactivity (presence in the environment, explanation, measurement, periods and activities, low doses, applications), fuel cycle (front end, mining and ore concentration, refining and conversion, fuel fabrication, in the reactor, back end with reprocessing and recycling, transport), the future of the thorium-based fuel cycle (motivations, benefits and drawbacks), nuclear reactors (principles of fission reactors, reactor types, PWR reactors, BWR, heavy-water reactor, high temperature reactor of HTR, future reactors), nuclear wastes (classification, packaging and storage, legal aspects, vitrification, choice of a deep storage option, quantities and costs, foreign practices), radioactive releases of nuclear installations (main released radio-elements, radioactive releases by nuclear reactors and by La Hague plant, gaseous and liquid effluents, impact of releases, regulation), the OSPAR Convention, management and safety of nuclear activities (from control to quality insurance, to quality management and to sustainable development), national safety bodies (mission, means, organisation and activities of ASN, IRSN, HCTISN), international bodies, nuclear and medicine (applications of radioactivity, medical imagery, radiotherapy, doses in nuclear medicine, implementation, the accident in Epinal), nuclear and R and D (past R and D programmes and expenses, main actors in France and present funding, main R and D axis, international cooperation)

  8. Physiological gas exchange mapping of hyperpolarized 129 Xe using spiral-IDEAL and MOXE in a model of regional radiation-induced lung injury.

    Science.gov (United States)

    Zanette, Brandon; Stirrat, Elaine; Jelveh, Salomeh; Hope, Andrew; Santyr, Giles

    2018-02-01

    To map physiological gas exchange parameters using dissolved hyperpolarized (HP) 129 Xe in a rat model of regional radiation-induced lung injury (RILI) with spiral-IDEAL and the model of xenon exchange (MOXE). Results are compared to quantitative histology of pulmonary tissue and red blood cell (RBC) distribution. Two cohorts (n = 6 each) of age-matched rats were used. One was irradiated in the right-medial lung, producing regional injury. Gas exchange was mapped 4 weeks postirradiation by imaging dissolved-phase HP 129 Xe using spiral-IDEAL at five gas exchange timepoints using a clinical 1.5 T scanner. Physiological lung parameters were extracted regionally on a voxel-wise basis using MOXE. Mean gas exchange parameters, specifically air-capillary barrier thickness (δ) and hematocrit (HCT) in the right-medial lung were compared to the contralateral lung as well as nonirradiated control animals. Whole-lung spectroscopic analysis of gas exchange was also performed. δ was significantly increased (1.43 ± 0.12 μm from 1.07 ± 0.09 μm) and HCT was significantly decreased (17.2 ± 1.2% from 23.6 ± 1.9%) in the right-medial lung (i.e., irradiated region) compared to the contralateral lung of the irradiated rats. These changes were not observed in healthy controls. δ and HCT correlated with histologically measured increases in pulmonary tissue heterogeneity (r = 0.77) and decreases in RBC distribution (r = 0.91), respectively. No changes were observed using whole-lung analysis. This work demonstrates the feasibility of mapping gas exchange using HP 129 Xe in an animal model of RILI 4 weeks postirradiation. Spatially resolved gas exchange mapping is sensitive to regional injury between cohorts that was undetected with whole-lung gas exchange analysis, in agreement with histology. Gas exchange mapping holds promise for assessing regional lung function in RILI and other pulmonary diseases. © 2017 The Authors. Medical Physics published by Wiley

  9. TEM study of xenon bubbles evolution in Xe-implanted Cu. Bubbles shape, epitaxial orientation and adsorption phenomenon

    International Nuclear Information System (INIS)

    Guillot, J.; Cartraud, M.; Garem, H.; Templier, C.; Desoyer, J.C.

    1987-01-01

    TEM is used to perform a study of xenon clusters changes in Xe-implanted Cu. After implantation, xenon is gathered into f.c.c. crystalline precipitates with a lattice parameter value of 0.580 nm. During annealing at 600 0 C large (110) facetted bubbles appear (2r≅35 nm) which contain fluid xenon. When cooling down to 100 K, xenon solidifies on bubbles facets in form of a thin membrane. The epitaxial orientations between solid xenon and copper are the same as adsorbed Xe on Cu(110) [fr

  10. First Demonstration of a Scintillating Xenon Bubble Chamber for Detecting Dark Matter and Coherent Elastic Neutrino-Nucleus Scattering

    Science.gov (United States)

    Baxter, D.; Chen, C. J.; Crisler, M.; Cwiok, T.; Dahl, C. E.; Grimsted, A.; Gupta, J.; Jin, M.; Puig, R.; Temples, D.; Zhang, J.

    2017-06-01

    A 30-g xenon bubble chamber, operated at Northwestern University in June and November 2016, has for the first time observed simultaneous bubble nucleation and scintillation by nuclear recoils in a superheated liquid. This chamber is instrumented with a CCD camera for near-IR bubble imaging, a solar-blind photomultiplier tube to detect 175-nm xenon scintillation light, and a piezoelectric acoustic transducer to detect the ultrasonic emission from a growing bubble. The time of nucleation determined from the acoustic signal is used to correlate specific scintillation pulses with bubble-nucleating events. We report on data from this chamber for thermodynamic "Seitz" thresholds from 4.2 to 15.0 keV. The observed single- and multiple-bubble rates when exposed to a Cf 252 neutron source indicate that, for an 8.3-keV thermodynamic threshold, the minimum nuclear recoil energy required to nucleate a bubble is 19 ±6 keV (1 σ uncertainty). This is consistent with the observed scintillation spectrum for bubble-nucleating events. We see no evidence for bubble nucleation by gamma rays at any of the thresholds studied, setting a 90% C.L. upper limit of 6.3 ×10-7 bubbles per gamma interaction at a 4.2-keV thermodynamic threshold. This indicates stronger gamma discrimination than in CF3 I bubble chambers, supporting the hypothesis that scintillation production suppresses bubble nucleation by electron recoils, while nuclear recoils nucleate bubbles as usual. These measurements establish the noble-liquid bubble chamber as a promising new technology for the detection of weakly interacting massive particle dark matter and coherent elastic neutrino-nucleus scattering.

  11. Axonal and glial currents activated during the post-tetanic hyperpolarization in non-myelinated nerve.

    Science.gov (United States)

    Robert, A; Jirounek, P

    1998-07-01

    Changes in membrane potential and potassium concentration in the extracellular space ([K+]e) of rabbit vagus nerve were measured simultaneously during electrical activity and during the period of recovery using a modified sucrose-gap method and potassium-sensitive microelectrodes. After stimulation for 15 s at 15 Hz the main activity-induced increase in [K+]e reached 16.9 mM. This increase in [K+]e was paralleled by a depolarization of the preparation. The period of activity was followed by a post-tetanic hyperpolarization (PTH) lasting tens of seconds, generated by the axonal electrogenic Na+-K+ pump and to a lesser extent by the pump of the surrounding Schwann cells. The amplitude of the PTH dramatically increased in experiments in which inward currents were blocked by removal of Cl– or after application of Cs+ or Ba2+, indicating that under normal conditions the current generated by the Na+-K+ pump is strongly short-circuited. A pharmacological and kinetic study showed that these currents are: (1) the hyperpolarization-activated current I h, and (2) the inwardly rectifying I KIR current. The results show that the latter originates from Schwann cells. Our data indicate that in non-myelinated nerves there is a subtle association of inward ionic channels which (1) helps the cell to maintain an optimal membrane potential after a period of activity, and (2) contributes to the removal of excess K+ from the extracellular space.

  12. MO-DE-206-03: Quantifying Metabolism with Hyperpolarized MR

    Energy Technology Data Exchange (ETDEWEB)

    Bankson, J. [The University of Texas M.D. Anderson Cancer Center (United States)

    2016-06-15

    In this symposium jointly sponsored by the World Molecular Imaging Society (WMIS) and the AAPM, luminary speakers on imaging metabolism will discuss three impactful topics. The first presentation on Cellular Metabolism of FDG will be given by Guillem Pratx (Stanford). This presentation will detail new work on looking at how the most common molecular imaging agent, fluoro-deoxy-glucose is metabolized at a cellular level. This will be followed by a talk on an improved approach to whole-body PET imaging by Simon Cherry (UC Davis). Simon’s work on a new whole-body PET imaging system promises to have dramatic improvement in our ability to detect and characterize cancer using PET. Finally, Jim Bankson (MD Anderson) will discuss extremely sophisticated approaches to quantifying hyperpolarized-13-C pyruvate metabolism using MR imaging. This technology promises to compliment the exquisite sensitivity of PET with an ability to measure not just uptake, but tumor metabolism. Learning Objectives: Understand the metabolism of FDG at a cellular level. Appreciate the engineering related to a novel new high-sensitivity whole-body PET imaging system. Understand the process of hyperpolarization, how pyruvate relates to metabolism and how advanced modeling can be used to better quantify this data. G. Pratx, Funding: 5R01CA186275, 1R21CA193001, and Damon Runyon Cancer Foundation. S. Cherry, National Institutes of Health; University of California, Davis; Siemens Medical SolutionsJ. Bankson, GE Healthcare; NCI P30-CA016672; CPRIT PR140021-P5.

  13. Quantified pH imaging with hyperpolarized (13) C-bicarbonate.

    Science.gov (United States)

    Scholz, David Johannes; Janich, Martin A; Köllisch, Ulrich; Schulte, Rolf F; Ardenkjaer-Larsen, Jan H; Frank, Annette; Haase, Axel; Schwaiger, Markus; Menzel, Marion I

    2015-06-01

    Because pH plays a crucial role in several diseases, it is desirable to measure pH in vivo noninvasively and in a spatially localized manner. Spatial maps of pH were quantified in vitro, with a focus on method-based errors, and applied in vivo. In vitro and in vivo (13) C mapping were performed for various flip angles for bicarbonate (BiC) and CO2 with spectral-spatial excitation and spiral readout in healthy Lewis rats in five slices. Acute subcutaneous sterile inflammation was induced with Concanavalin A in the right leg of Buffalo rats. pH and proton images were measured 2 h after induction. After optimizing the signal to noise ratio of the hyperpolarized (13) C-bicarbonate, error estimation of the spectral-spatial excited spectrum reveals that the method covers the biologically relevant pH range of 6 to 8 with low pH error (< 0.2). Quantification of pH maps shows negligible impact of the residual bicarbonate signal. pH maps reflect the induction of acute metabolic alkalosis. Inflamed, infected regions exhibit lower pH. Hyperpolarized (13) C-bicarbonate pH mapping was shown to be sensitive in the biologically relevant pH range. The mapping of pH was applied to healthy in vivo organs and interpreted within inflammation and acute metabolic alkalosis models. © 2014 Wiley Periodicals, Inc.

  14. Role of an inward rectifier K+ current and of hyperpolarization in human myoblast fusion

    Science.gov (United States)

    Liu, J-H; Bijlenga, P; Fischer-Lougheed, J; Occhiodoro, T; Kaelin, A; Bader, C R; Bernheim, L

    1998-01-01

    The role of K+ channels and membrane potential in myoblast fusion was evaluated by examining resting membrane potential and timing of expression of K+ currents at three stages of differentiation of human myogenic cells: undifferentiated myoblasts, fusion-competent myoblasts (FCMBs), and freshly formed myotubes. Two K+ currents contribute to a hyperpolarization of myoblasts prior to fusion: IK(NI), a non-inactivating delayed rectifier, and IK(IR), an inward rectifier. IK(NI) density is low in undifferentiated myoblasts, increases in FCMBs and declines in myotubes. On the other hand, IK(IR) is expressed in 28 % of the FCMBs and in all myotubes. IK(IR) is reversibly blocked by Ba2+ or Cs+. Cells expressing IK(IR) have resting membrane potentials of −65 mV. A block by Ba2+ or Cs+ induces a depolarization to a voltage determined by IK(NI) (−32 mV). Cs+ and Ba2+ ions reduce myoblast fusion. It is hypothesized that the IK(IR)-mediated hyperpolarization allows FCMBs to recruit Na+, K+ and T-type Ca2+ channels which are present in these cells and would otherwise be inactivated. FCMBs, rendered thereby capable of firing action potentials, could amplify depolarizing signals and may accelerate fusion. PMID:9705997

  15. Molecular MRI in the Earth's Magnetic Field Using Continuous Hyperpolarization of a Biomolecule in Water.

    Science.gov (United States)

    Rovedo, Philipp; Knecht, Stephan; Bäumlisberger, Tim; Cremer, Anna Lena; Duckett, Simon B; Mewis, Ryan E; Green, Gary G R; Burns, Michael; Rayner, Peter J; Leibfritz, Dieter; Korvink, Jan G; Hennig, Jürgen; Pütz, Gerhard; von Elverfeldt, Dominik; Hövener, Jan-Bernd

    2016-06-30

    In this work, we illustrate a method to continuously hyperpolarize a biomolecule, nicotinamide, in water using parahydrogen and signal amplification by reversible exchange (SABRE). Building on the preparation procedure described recently by Truong et al. [ J. Phys. Chem. B , 2014 , 118 , 13882 - 13889 ], aqueous solutions of nicotinamide and an Ir-IMes catalyst were prepared for low-field NMR and MRI. The (1)H-polarization was continuously renewed and monitored by NMR experiments at 5.9 mT for more than 1000 s. The polarization achieved corresponds to that induced by a 46 T magnet (P = 1.6 × 10(-4)) or an enhancement of 10(4). The polarization persisted, although reduced, if cell culture medium (DPBS with Ca(2+) and Mg(2+)) or human cells (HL-60) were added, but was no longer observable after the addition of human blood. Using a portable MRI unit, fast (1)H-MRI was enabled by cycling the magnetic field between 5 mT and the Earth's field for hyperpolarization and imaging, respectively. A model describing the underlying spin physics was developed that revealed a polarization pattern depending on both contact time and magnetic field. Furthermore, the model predicts an opposite phase of the dihydrogen and substrate signal after one exchange, which is likely to result in the cancelation of some signal at low field.

  16. Numerical study on xenon positive column discharges of mercury-free lamp

    International Nuclear Information System (INIS)

    Ouyang, Jiting; He, Feng; Miao, Jinsong; Wang, Jianqi; Hu, Wenbo

    2007-01-01

    In this paper, the numerical study has been performed on the xenon positive column discharges of mercury-free fluorescent lamp. The plasma discharge characteristics are analyzed by numerical simulation based on two-dimensional fluid model. The effects of cell geometry, such as the dielectric layer, the electrode width, the electrode gap, and the cell height, and the filling gas including the pressure and the xenon percentage are investigated in terms of discharge current and discharge efficiency. The results show that a long transient positive column will form in the xenon lamp when applying ac sinusoidal power and the lamp can operate in a large range of voltage and frequency. The front dielectric layer of the cell plays an important role in the xenon lamp while the back layer has little effect. The ratio of electrode gap to cell height should be large to achieve a long positive column xenon lamp and higher efficiency. Increase of pressure or xenon concentration results in an increase of discharge efficiency and voltage. The discussions will be helpful for the design of commercial xenon lamp cells

  17. Removing krypton from xenon by cryogenic distillation to the ppq level

    Energy Technology Data Exchange (ETDEWEB)

    Aprile, E.; Anthony, M.; De Perio, P.; Gao, F.; Goetzke, L.W.; Greene, Z.; Messina, M.; Plante, G.; Rizzo, A.; Zhang, Y. [Columbia University, Physics Department, New York, NY (United States); Aalbers, J.; Breur, P.A.; Brown, A.; Colijn, A.P.; Decowski, M.P.; Hogenbirk, E.; Tiseni, A. [Nikhef and the University of Amsterdam, Science Park, Amsterdam (Netherlands); Agostini, F. [INFN-Laboratori Nazionali del Gran Sasso (Italy); Gran Sasso Science Institute, L' Aquila (Italy); University of Bologna, Department of Physics and Astrophysics, Bologna (Italy); INFN-Bologna (Italy); Alfonsi, M.; Geis, C.; Grignon, C.; Oberlack, U.; Scheibelhut, M.; Schindler, S. [Johannes Gutenberg-Universitaet Mainz, Institut fuer Physik and Exzellenzcluster PRISMA, Mainz (Germany); Amaro, F.D.; Cardoso, J.M.R.; Lopes, J.A.M.; Orrigo, S.E.A.; Santos, J.M.F. dos; Silva, M. [University of Coimbra, Department of Physics, Coimbra (Portugal); Arneodo, F.; Benabderrahmane, M.L.; Di Giovanni, A.; Maris, I. [New York University Abu Dhabi, Abu Dhabi (United Arab Emirates); Barrow, P.; Baudis, L.; Franco, D.; Galloway, M.; Kessler, G.; Kish, A.; Mayani, D.; Pakarha, P.; Piastra, F.; Wei, Y.; Wulf, J. [Physik-Institut, University of Zurich, Zurich (Switzerland); Bauermeister, B. [Johannes Gutenberg-Universitaet Mainz, Institut fuer Physik and Exzellenzcluster PRISMA, Mainz (Germany); Stockholm University, AlbaNova, Oskar Klein Centre, Department of Physics, Stockholm (Sweden); Berger, T.; Brown, E.; Piro, M.C. [Rensselaer Polytechnic Institute, Department of Physics, Applied Physics and Astronomy, Troy, NY (United States); Bruenner, S.; Cichon, D.; Eurin, G.; Hasterok, C.; Lindemann, S.; Lindner, M.; Undagoitia, T.M.; Pizzella, V.; Rauch, L.; Rupp, N.; Schreiner, J.; Simgen, H. [Max-Planck-Institut fuer Kernphysik, Heidelberg (Germany); Bruno, G.; Gallo Rosso, A.; Molinario, A. [INFN-Laboratori Nazionali del Gran Sasso (Italy); Gran Sasso Science Institute, L' Aquila (Italy); Budnik, R.; Duchovni, E.; Itay, R.; Landsman, H.; Lellouch, D.; Levinson, L.; Manfredini, A.; Priel, N. [Weizmann Institute of Science, Department of Particle Physics and Astrophysics, Rehovot (Israel); Buetikofer, L.; Coderre, D.; Kaminsky, B.; Schumann, M.; Sivers, M. v. [Universitaet Freiburg, Physikalisches Institut, Freiburg (Germany); Calven, J.; Conrad, J.; Ferella, A.D.; Pelssers, B. [Stockholm University, AlbaNova, Oskar Klein Centre, Department of Physics, Stockholm (Sweden); Cervantes, M.; Lang, R.F.; Masson, D.; Pienaar, J.; Reichard, S.; Reuter, C. [Purdue University, Department of Physics and Astronomy, West Lafayette, IN (United States); Cussonneau, J.P.; Diglio, S.; Le Calloch, M.; Masbou, J.; Micheneau, K.; Persiani, R.; Thers, D. [Universite de Nantes, SUBATECH, Ecole des Mines de Nantes, CNRS/In2p3, Nantes (France); Di Gangi, P.; Garbini, M.; Massoli, F.V.; Sartorelli, G.; Selvi, M. [University of Bologna, Department of Physics and Astrophysics, Bologna (Italy); INFN-Bologna (Italy); Fei, J.; Ni, K.; Ye, J. [University of California, Department of Physics, San Diego, CA (United States); Fieguth, A.; Huhmann, C.; Murra, M.; Rosendahl, S.; Weinheimer, C. [Westfaelische Wilhelms-Universitaet Muenster, Institut fuer Kernphysik, Muenster (Germany); Fulgione, W. [INFN-Laboratori Nazionali del Gran Sasso and Gran Sasso Science Institute, L' Aquila (Italy); INFN-Torino (Italy); Osservatorio Astrofisico di Torino, Torino (Italy); Grandi, L.; Saldanha, R.; Shockley, E.; Upole, N. [University of Chicago, Department of Physics and Kavli Institute of Cosmological Physics, Chicago, IL (United States); Lin, Q. [Laboratori Nazionali del Gran Sasso, Assergi (Italy); Meng, Y.; Stein, A.; Wang, H. [University of California, Physics and Astronomy Department, Los Angeles, CA (United States); Miguez, B.; Trinchero, G. [INFN-Torino (Italy); Osservatorio Astrofisico di Torino, Torino (Italy); Naganoma, J.; Shagin, P. [Rice University, Department of Physics and Astronomy, Houston, TX (United States); Lavina, L.S. [LPNHE, Universite Pierre et Marie Curie, Universite Paris Diderot, CNRS/IN2P3, Paris (France); Tunnell, C. [Nikhef and the University of Amsterdam, Science Park, Amsterdam (Netherlands); University of Chicago, Department of Physics and Kavli Institute of Cosmological Physics, Chicago, IL (United States); Cristescu, I. [Karlsruhe Institute of Technology, Tritium Laboratory Karlsruhe, Eggenstein-Leopoldshafen (Germany); Collaboration: XENON Collaboration

    2017-05-15

    The XENON1T experiment aims for the direct detection of dark matter in a detector filled with 3.3 tons of liquid xenon. In order to achieve the desired sensitivity, the background induced by radioactive decays inside the detector has to be sufficiently low. One major contributor is the β-emitter {sup 85}Kr which is present in the xenon. For XENON1T a concentration of natural krypton in xenon {sup nat}Kr/Xe < 200 ppq (parts per quadrillion, 1 ppq = 10{sup -15} mol/mol) is required. In this work, the design, construction and test of a novel cryogenic distillation column using the common McCabe-Thiele approach is described. The system demonstrated a krypton reduction factor of 6.4 . 10{sup 5} with thermodynamic stability at process speeds above 3 kg/h. The resulting concentration of {sup nat}Kr/Xe < 26 ppq is the lowest ever achieved, almost one order of magnitude below the requirements for XENON1T and even sufficient for future dark matter experiments using liquid xenon, such as XENONnT and DARWIN. (orig.)

  18. Ionization and scintillation response of high-pressure xenon gas to alpha particles

    International Nuclear Information System (INIS)

    Álvarez, V; Cárcel, S; Cervera, A; Díaz, J; Ferrario, P; Gil, A; Gómez-Cadenas, J J; Borges, F I G; Conde, C A N; Fernandes, L M P; Freitas, E D C; Cebrián, S; Dafni, T; Gómez, H; Egorov, M; Gehman, V M; Goldschmidt, A; Esteve, R; Evtoukhovitch, P; Ferreira, A L

    2013-01-01

    High-pressure xenon gas is an attractive detection medium for a variety of applications in fundamental and applied physics. In this paper we study the ionization and scintillation detection properties of xenon gas at 10 bar pressure. For this purpose, we use a source of alpha particles in the NEXT-DEMO time projection chamber, the large scale prototype of the NEXT-100 neutrinoless double beta decay experiment, in three different drift electric field configurations. We measure the ionization electron drift velocity and longitudinal diffusion, and compare our results to expectations based on available electron scattering cross sections on pure xenon. In addition, two types of measurements addressing the connection between the ionization and scintillation yields are performed. On the one hand we observe, for the first time in xenon gas, large event-by-event correlated fluctuations between the ionization and scintillation signals, similar to that already observed in liquid xenon. On the other hand, we study the field dependence of the average scintillation and ionization yields. Both types of measurements may shed light on the mechanism of electron-ion recombination in xenon gas for highly-ionizing particles. Finally, by comparing the response of alpha particles and electrons in NEXT-DEMO, we find no evidence for quenching of the primary scintillation light produced by alpha particles in the xenon gas.

  19. New constraints and prospects for sub-GeV dark matter scattering off electrons in xenon

    Science.gov (United States)

    Essig, Rouven; Volansky, Tomer; Yu, Tien-Tien

    2017-08-01

    We study in detail sub-GeV dark matter scattering off electrons in xenon, including the expected electron recoil spectra and annual modulation spectra. We derive improved constraints using low-energy XENON10 and XENON100 ionization-only data. For XENON10, in addition to including electron-recoil data corresponding to about 1-3 electrons, we include for the first time events corresponding to about 4-7 electrons. Assuming the scattering is momentum independent (FDM=1 ), this strengthens a previous cross-section bound by almost an order of magnitude for dark matter masses above 50 MeV. The available XENON100 data corresponds to events with about 4-50 electrons, and leads to a constraint that is comparable to the XENON10 bound above 50 MeV for FDM=1 . We demonstrate that a search for an annual modulation signal in upcoming xenon experiments (XENON1T, XENONnT, LZ) could substantially improve the above bounds even in the presence of large backgrounds. We also emphasize that in simple benchmark models of sub-GeV dark matter, the dark matter-electron scattering rate can be as high as one event every ten (two) seconds in the XENON1T (XENONnT or LZ) experiments, without being in conflict with any other known experimental bounds. While there are several sources of backgrounds that can produce single- or few-electron events, a large event rate can be consistent with a dark matter signal and should not be simply written off as purely a detector curiosity. This fact motivates a detailed analysis of the ionization-data ("S2") data, taking into account the expected annual modulation spectrum of the signal rate, as well as the DM-induced electron-recoil spectra, which are another powerful discriminant between signal and background.

  20. Xenon Acquisition Strategies for High-Power Electric Propulsion NASA Missions

    Science.gov (United States)

    Herman, Daniel A.; Unfried, Kenneth G.

    2015-01-01

    Solar electric propulsion (SEP) has been used for station-keeping of geostationary communications satellites since the 1980s. Solar electric propulsion has also benefitted from success on NASA Science Missions such as Deep Space One and Dawn. The xenon propellant loads for these applications have been in the 100s of kilograms range. Recent studies performed for NASA's Human Exploration and Operations Mission Directorate (HEOMD) have demonstrated that SEP is critically enabling for both near-term and future exploration architectures. The high payoff for both human and science exploration missions and technology investment from NASA's Space Technology Mission Directorate (STMD) are providing the necessary convergence and impetus for a 30-kilowatt-class SEP mission. Multiple 30-50- kilowatt Solar Electric Propulsion Technology Demonstration Mission (SEP TDM) concepts have been developed based on the maturing electric propulsion and solar array technologies by STMD with recent efforts focusing on an Asteroid Redirect Robotic Mission (ARRM). Xenon is the optimal propellant for the existing state-of-the-art electric propulsion systems considering efficiency, storability, and contamination potential. NASA mission concepts developed and those proposed by contracted efforts for the 30-kilowatt-class demonstration have a range of xenon propellant loads from 100s of kilograms up to 10,000 kilograms. This paper examines the status of the xenon industry worldwide, including historical xenon supply and pricing. The paper will provide updated information on the xenon market relative to previous papers that discussed xenon production relative to NASA mission needs. The paper will discuss the various approaches for acquiring on the order of 10 metric tons of xenon propellant to support potential near-term NASA missions. Finally, the paper will discuss acquisitions strategies for larger NASA missions requiring 100s of metric tons of xenon will be discussed.

  1. Potential for large-scale uses for fission-product Xenon

    International Nuclear Information System (INIS)

    Rohrmann, C.A.

    1983-03-01

    Of all fission products in spent, low-enrichment-uranium power-reactor fuels, xenon is produced in the highest yield - nearly one cubic meter, STP, per metric ton. In aged fuels which may be considered for processing in the US, radioactive xenon isotopes approach the lowest limits of detection. The separation from accompanying radioactive 85 Kr is the essential problem; however, this is state-of-the-art technology which has been demonstrated on the pilot scale to yield xenon with pico-curie levels of 85 Kr contamination. If needed for special applications, such levels could be further reduced. Environmental considerations require the isolation of essentially all fission-product krypton during fuel processing. Economic restraints assure that the bulk of this krypton will need to be separated from the much-more-voluminous xenon fraction of the total amount of fission gas. Xenon may thus be discarded or made available for uses at probably very low cost. In contrast with many other fission products which have unique radioactive characteristics which make them useful as sources of heat, gamma and x-rays, and luminescence - as well as for medicinal diagnostics and therapeutics - fission-product xenon differs from naturally occurring xenon only in its isotopic composition which gives it a slightly hgiher atomic weight, because of the much higher concentrations of the 134 Xe and 136 Xe isotopes. Therefore, fission-product xenon can most likely find uses in applications which already exist but which can not be exploited most beneficially because of the high cost and scarcity of natural xenon. Unique uses would probably include applications in improved incandescent light illumination in place of krypton and in human anesthesia

  2. Evaluation of activated charcoal for dynamic adsorption of krypton and xenon

    International Nuclear Information System (INIS)

    Khan, A.A.; Deshingkar, D.S.; Ramarathinam, K.; Kishore, A.G.

    1975-01-01

    From the standpoint of radiation safety, the release of radioactive krypton and xenon from power reactors should be kept as low as practicable. The decay of shortlived isotopes of krypton and xenon by adsorptive delay on activated charcoal has shown promising results for this purpose. The delay provided by activated charcoal is proportional to the dynamic adsorption coefficients of these gases which are characteristic of the adsorbent. These coefficients were determined for krypton and xenon on indigenous gas-adsorbing activated charcoal at different moisture contents of carrier air stream and activated charcoal, concentrations of krypton around ambient temperatures, to find its suitability for designing adsorber columns. (author)

  3. Online {sup 222}Rn removal by cryogenic distillation in the XENON100 experiment

    Energy Technology Data Exchange (ETDEWEB)

    Aprile, E.; Anthony, M.; De Perio, P.; Gao, F.; Goetzke, L.W.; Greene, Z.; Lin, Q.; Messina, M.; Plante, G.; Rizzo, A.; Zhang, Y. [Columbia University, Physics Department, New York, NY (United States); Aalbers, J.; Breur, P.A.; Brown, A.; Colijn, A.P.; Decowski, M.P.; Hogenbirk, E.; Tiseni, A. [Nikhef and the University of Amsterdam, Science Park, Amsterdam (Netherlands); Agostini, F. [INFN-Laboratori Nazionali del Gran Sasso and Gran Sasso Science Institute, L' Aquila (Italy); University of Bologna, Department of Physics and Astrophysics, Bologna (Italy); INFN-Bologna (Italy); Alfonsi, M.; Geis, C.; Grignon, C.; Oberlack, U.; Scheibelhut, M.; Schindler, S. [Johannes Gutenberg-Universitaet Mainz, Institut fuer Physik and Exzellenzcluster PRISMA, Mainz (Germany); Amaro, F.D.; Cardoso, J.M.R.; Lopes, J.A.M.; Orrigo, S.E.A.; Santos, J.M.F. dos; Silva, M. [University of Coimbra, Department of Physics, Coimbra (Portugal); Arneodo, F.; Benabderrahmane, M.L.; Di Giovanni, A.; Maris, I. [New York University Abu Dhabi, Abu Dhabi (United Arab Emirates); Barrow, P.; Baudis, L.; Franco, D.; Galloway, M.; Kessler, G.; Kish, A.; Mayani, D.; Pakarha, P.; Piastra, F.; Wei, Y.; Wulf, J. [University of Zurich, Physik-Institut, Zurich (Switzerland); Bauermeister, B. [Johannes Gutenberg-Universitaet Mainz, Institut fuer Physik and Exzellenzcluster PRISMA, Mainz (Germany); Stockholm University, AlbaNova, Department of Physics, Oskar Klein Centre, Stockholm (Sweden); Berger, T.; Brown, E.; Piro, M.C. [Rensselaer Polytechnic Institute, Department of Physics, Applied Physics and Astronomy, Troy, NY (United States); Bruenner, S.; Cichon, D.; Eurin, G.; Hasterok, C.; Lindner, M.; Undagoitia, T.M.; Pizzella, V.; Rauch, L.; Rupp, N.; Schreiner, J.; Simgen, H. [Max-Planck-Institut fuer Kernphysik, Heidelberg (Germany); Bruno, G.; Gallo Rosso, A.; Molinario, A. [INFN-Laboratori Nazionali del Gran Sasso and Gran Sasso Science Institute, L' Aquila (Italy); Budnik, R.; Duchovni, E.; Itay, R.; Landsman, H.; Lellouch, D.; Levinson, L.; Manfredini, A.; Priel, N. [Weizmann Institute of Science, Department of Particle Physics and Astrophysics, Rehovot (Israel); Buetikofer, L.; Coderre, D.; Kaminsky, B.; Schumann, M.; Sivers, M. v. [Universitaet Freiburg, Physikalisches Institut, Freiburg (Germany); Calven, J.; Conrad, J.; Ferella, A.D.; Pelssers, B. [Stockholm University, AlbaNova, Department of Physics, Oskar Klein Centre, Stockholm (Sweden); Cervantes, M.; Lang, R.F.; Masson, D.; Pienaar, J.; Reichard, S.; Reuter, C. [Purdue University, Department of Physics and Astronomy, West Lafayette, IN (United States); Cussonneau, J.P.; Diglio, S.; Le Calloch, M.; Masbou, J.; Micheneau, K.; Persiani, R.; Thers, D. [Universite de Nantes, SUBATECH, Ecole des Mines de Nantes, CNRS/In2p3, Nantes (France); Di Gangi, P.; Garbini, M.; Massoli, F.V.; Sartorelli, G.; Selvi, M. [University of Bologna, Department of Physics and Astrophysics, Bologna (Italy); INFN, Bologna (Italy); Fei, J.; Ni, K.; Ye, J. [University of California, Department of Physics, San Diego, CA (United States); Fieguth, A.; Murra, M.; Rosendahl, S.; Weinheimer, C. [Westfaelische Wilhelms-Universitaet Muenster, Institut fuer Kernphysik, Muenster (Germany); Fulgione, W. [INFN-Laboratori Nazionali del Gran Sasso and Gran Sasso Science Institute, L' Aquila (Italy); INFN-Torino (Italy); Osservatorio Astrofisico di Torino, Turin (Italy); Grandi, L.; Saldanha, R.; Shockley, E.; Upole, N. [University of Chicago, Department of Physics and Kavli Institute of Cosmological Physics, Chicago, IL (United States); Lindemann, S. [Max-Planck-Institut fuer Kernphysik, Heidelberg (Germany); Universitaet Freiburg, Physikalisches Institut, Freiburg (Germany); Meng, Y.; Stein, A.; Wang, H. [University of California, Physics and Astronomy Department, Los Angeles, CA (United States); Miguez, B.; Trinchero, G. [INFN-Torino (Italy); Osservatorio Astrofisico di Torino, Turin (Italy); Naganoma, J.; Shagin, P. [Rice University, Department of Physics and Astronomy, Houston, TX (United States); Lavina, L.S. [LPNHE, Universite Pierre et Marie Curie, Universite Paris Diderot, CNRS/IN2P3, Paris (France); Tunnell, C. [Nikhef and the University of Amsterdam, Science Park, Amsterdam (Netherlands); University of Chicago, Department of Physics and Kavli Institute of Cosmological Physics, Chicago, IL (United States); Cristescu, I. [Karlsruhe Institute of Technology, Tritium Laboratory Karlsruhe, Eggenstein-Leopoldshafen (Germany); Collaboration: XENON Collaboration

    2017-06-15

    We describe the purification of xenon from traces of the radioactive noble gas radon using a cryogenic distillation column. The distillation column was integrated into the gas purification loop of the XENON100 detector for online radon removal. This enabled us to significantly reduce the constant {sup 222}Rn background originating from radon emanation. After inserting an auxiliary {sup 222}Rn emanation source in the gas loop, we determined a radon reduction factor of R > 27 (95% C.L.) for the distillation column by monitoring the {sup 222}Rn activity concentration inside the XENON100 detector. (orig.)

  4. Global characteristics of an ATON stationary plasma thruster operating with krypton and xenon

    International Nuclear Information System (INIS)

    Bugrova, A.I.; Lipatov, A.S.; Solomatina, L.V.; Morozov, A.I.

    2002-01-01

    Paper contains the experimental results of operation of the ATON plasma thruster operating with krypton and xenon. It is shown that consumption of a working gas for consumption of a working gas the krypton base thrust is higher in contrast to xenon base one at lower efficiency. In case of krypton use one obtained the efficiency constituting ∼ 60% at specific pulse reaching 3000 s. Jet divergence in case of krypton use is ∼ ± 22 deg in contrast to ∼ ± 11 deg in case of xenon use [ru

  5. X-ray detector for automatic exposure control using ionization chamber filled with xenon gas

    CERN Document Server

    Nakagawa, A; Yoshida, T

    2003-01-01

    This report refers to our newly developed X-ray detector for reliable automatic X-ray exposure control, which is to be widely used for X-ray diagnoses in various clinical fields. This new detector utilizes an ionization chamber filled with xenon gas, in contrast to conventional X-ray detectors which use ionization chambers filled with air. Use of xenon gas ensures higher sensitivity and thinner design of the detector. The xenon gas is completely sealed in the chamber, so that the influence of the changes in ambient environments is minimized. (author)

  6. Research on the measurement of the ultraviolet irradiance in the xenon lamp aging test chamber

    Science.gov (United States)

    Ji, Muyao; Li, Tiecheng; Lin, Fangsheng; Yin, Dejin; Cheng, Weihai; Huang, Biyong; Lai, Lei; Xia, Ming

    2018-01-01

    This paper briefly introduces the methods of calibrating the irradiance in the Xenon lamp aging test chamber. And the irradiance under ultraviolet region is mainly researched. Three different detectors whose response wave range are respectively UVA (320 400nm), UVB (275 330nm) and UVA+B (280 400nm) are used in the experiment. Through comparing the measuring results with different detectors under the same xenon lamp source, we discuss the difference between UVA, UVB and UVA+B on the basis of the spectrum of the xenon lamp and the response curve of the detectors. We also point out the possible error source, when use these detectors to calibrate the chamber.

  7. Acute afterload-imposed change in porcine cardiac metabolism imaged by hyperpolarized [1-13C]Pyruvate

    DEFF Research Database (Denmark)

    Tougaard, Rasmus Stilling; Søvsø Szocska Hansen, Esben; Laustsen, Christoffer

    Deranged metabolism is now considered a key causal factor in heart failure and has therefore gained considerable scientific interest. The novel technique hyperpolarized MR has emerged as a leading methodological candidate to study these derangements. We employed a clinically relevant, large animal...

  8. Ex vivo hyperpolarized MR spectroscopy on isolated renal tubular cells: A novel technique for cell energy phenotyping.

    Science.gov (United States)

    Juul, Troels; Palm, Fredrik; Nielsen, Per Mose; Bertelsen, Lotte Bonde; Laustsen, Christoffer

    2017-08-01

    It has been demonstrated that hyperpolarized 13 C MR is a useful tool to study cultured cells. However, cells in culture can alter phenotype, which raises concerns regarding the in vivo significance of such findings. Here we investigate if metabolic phenotyping using hyperpolarized 13 C MR is suitable for cells isolated from kidney tissue, without prior cell culture. Isolation of tubular cells from freshly excised kidney tissue and treatment with either ouabain or antimycin A was investigated with hyperpolarized MR spectroscopy on a 9.4 Tesla preclinical imaging system. Isolation of tubular cells from less than 2 g of kidney tissue generally resulted in more than 10 million live tubular cells. This amount of cells was enough to yield robust signals from the conversion of 13 C-pyruvate to lactate, bicarbonate and alanine, demonstrating that metabolic flux by means of both anaerobic and aerobic pathways can be quantified using this technique. Ex vivo metabolic phenotyping using hyperpolarized 13 C MR in a preclinical system is a useful technique to study energy metabolism in freshly isolated renal tubular cells. This technique has the potential to advance our understanding of both normal cell physiology as well as pathological processes contributing to kidney disease. Magn Reson Med 78:457-461, 2017. © 2016 International Society for Magnetic Resonance in Medicine. © 2016 International Society for Magnetic Resonance in Medicine.

  9. Xenon oscillation in a large PHWR core (Atucha II type): TRISIC code applicability

    International Nuclear Information System (INIS)

    Solanilla, Roberto

    2000-01-01

    A three dimensional nuclear reactor simulation code (TRISIC) was developed many years ago to design a PHWR (pressurizer heavy water reactors - Atucha type) based in the 'source-sink model' (heterogeneous theory). The limited processor computational performance available at that time was the constraint of the code when a detailed reactor description was necessary. A modern PC (pentium) code version with a full reactor core representation (461 fuel channels) including diagonal control rod banks and flux-reading detectors with theirs tube guide was used in the present paper for simulation of the Xenon transient when a local asymmetric perturbation was produced in a large core (Atucha II type). The results obtained and the computer time required for the 70 hour's simulation with an adequate time step, established the potential of the code to deal with this kind of transients. The paper shows that the method of TRISIC allows to detect and control azimuthal, radial and axial oscillation. This code is a proper way to elaborate a program of control rods movement from the flux reading detectors to damp the oscillation. TRISIC could also be a accurate tool to supervise the full core flux distribution in real time during the operation of the reactor. (author)

  10. Photoionization of xenon below the atomic ionization potential

    International Nuclear Information System (INIS)

    Laporte, P.; Saile, V.; Reininger, R.; Asaf, U.; Steinberger, I.T.

    1982-10-01

    Experiments using monochromated synchrotron radiation revealed that for densities of the order of 10 19 atoms/cm 3 and more xenon exhibits a continuous photoresponse excitation spectrum below the atomic ionization potential (12.12 eV). The lower limit of the continuum is at about 11.10 eV, the energy difference between the ground state of the molecular ion Xe 2+ and that of the free atom. This is attributed to the Hornbeck-Molnar process occurring at the line wings as well as at the line centres. Dips appearing in the continuum very near to positions of atomic lines are discussed invoking the quasi-static theory. (orig.)

  11. Background in xenon filled X-ray detectors

    International Nuclear Information System (INIS)

    Feroci, M.; Costa, E.; Dwyer, J.; Ford, E.; Kaaret, P.; Rapisarda, M.; Soffitta, P.

    1995-01-01

    Xenon based gas mixtures have been often used in proportional counters for X-ray astronomy in order to achieve a good efficiency in the medium/high X-ray energy range. Proportional counters flown on past missions (i.e. HEAO1 and EXOSAT) filled with Xe-based mixtures have shown a higher residual background (after that all the rejection techniques have been applied) with respect to Ar-based ones, operating in the same energy band and in the same radiation environment. We show, by means of Monte Carlo simulations, analytical computations and laboratory measurements, that such difference can be mostly understood in terms of higher internal background production and lower pulse discrimination efficiency in Xe-based gas filling, with respect to Ar-based ones. (orig.)

  12. Mechanisms of Xenon Effect on Skin and Red Blood Cells

    DEFF Research Database (Denmark)

    Ponomarev, Alexander; Rodin, V.; Gurevich, Leonid

    2017-01-01

    The usage of Xenon (Xe) is known in anesthesia and biobanking areas. It is considered preservation effect of Xe is associated either with clathrate formation - solid gaseous structures or dissolution of Xe molecules in liquid phase without physical state modification (so-called hyperbarium) [1......]. This study is addressed to establish differences between hyberbarium or clathrate Xe actions as well as its applications on various bioobjects with anaerobic - red blood cells (RBCs) and aerobic (skin fragments) metabolism. Xe clathrates and hyperbarium storage were simulated under 277 K and 620-725 k...... to control (15.68 ± 1.11, CI95%). Skin fragments were harvested from rat tails and divided on hyberbarium, clathrate and dimetylsulfoxide cryopreserved as control group and stored for 7 days. Assessment was performed by point-score method including epidermal-dermal integrity various assays and engraftment...

  13. Topological signature in the NEXT high pressure xenon TPC

    Science.gov (United States)

    Ferrario, Paola; NEXT Collaboration

    2017-09-01

    The NEXT experiment aims to observe the neutrinoless double beta decay of 136Xe in a high-pressure xenon gas TPC using electroluminescence to amplify the signal from ionization. One of the main advantages of this technology is the possibility to use the topology of events with energies close to Qββ as an extra tool to reject background. In these proceedings we show with data from prototypes that an extra background rejection factor of 24.3 ± 1.4 (stat.)% can be achieved, while maintaining an efficiency of 66.7 ± 1.% for signal events. The performance expected in NEW, the next stage of the experiment, is to improve to 12.9% ± 0.6% background acceptance for 66.9% ± 0.6% signal efficiency.

  14. Reflectance dependence of polytetrafluoroethylene on thickness for xenon scintillation light

    Energy Technology Data Exchange (ETDEWEB)

    Haefner, J.; Neff, A.; Arthurs, M.; Batista, E.; Morton, D.; Okunawo, M.; Pushkin, K.; Sander, A. [Randall Laboratory of Physics, University of Michigan, Ann Arbor, MI 48109-1040 (United States); Stephenson, S. [Randall Laboratory of Physics, University of Michigan, Ann Arbor, MI 48109-1040 (United States); University of California Davis, Department of Physics, One Shields Ave., Davis, CA 95616 (United States); Wang, Y. [Randall Laboratory of Physics, University of Michigan, Ann Arbor, MI 48109-1040 (United States); Lorenzon, W., E-mail: lorenzon@umich.edu [Randall Laboratory of Physics, University of Michigan, Ann Arbor, MI 48109-1040 (United States)

    2017-06-01

    Many rare event searches including dark matter direct detection and neutrinoless double beta decay experiments take advantage of the high VUV reflective surfaces made from polytetrafluoroethylene (PTFE) reflector materials to achieve high light collection efficiency in their detectors. As the detectors have grown in size over the past decade, there has also been an increased need for ever thinner detector walls without significant loss in reflectance to reduce dead volumes around active noble liquids, outgassing, and potential backgrounds. We report on the experimental results to measure the dependence of the reflectance on thickness of two PTFE samples at wavelengths near 178 nm. No change in reflectance was observed as the wall thickness of a cylindrically shaped PTFE vessel immersed in liquid xenon was varied between 1 mm to 9.5 mm.

  15. Gamma-ray spectrometer utilizing xenon at high pressure

    International Nuclear Information System (INIS)

    Smith, G.C.; Mahler, G.J.; Yu, B.; Kane, W.R.; Markey, J.K.

    1994-01-01

    A prototype gamma-ray spectrometer utilizing xenon gas near the critical point (166 degrees C, 58 atm) is under development. The spectrometer will function as a room-temperature ionization chamber detecting gamma rays in the energy range 100 keV2 MeV, with an energy resolution intermediate between semiconductor (Ge) and scintillation (NaI) spectrometers. The energy resolution is superior to that of a NaI scintillation spectrometer by a substantial margin (approximately a factor 5), and accordingly, much more information can be extracted from a given gamma-ray spectrum. Unlike germanium detectors, the spectrometer possesses the capability for sustained operation under ambient temperature conditions without a requirement for liquid nitrogen

  16. Electron Drift Properties in High Pressure Gaseous Xenon

    Energy Technology Data Exchange (ETDEWEB)

    Simón, A.; et al.

    2018-04-05

    Gaseous time projection chambers (TPC) are a very attractive detector technology for particle tracking. Characterization of both drift velocity and diffusion is of great importance to correctly assess their tracking capabilities. NEXT-White is a High Pressure Xenon gas TPC with electroluminescent amplification, a 1:2 scale model of the future NEXT-100 detector, which will be dedicated to neutrinoless double beta decay searches. NEXT-White has been operating at Canfranc Underground Laboratory (LSC) since December 2016. The drift parameters have been measured using $^{83m}$Kr for a range of reduced drift fields at two different pressure regimes, namely 7.2 bar and 9.1 bar. The results have been compared with Magboltz simulations. Agreement at the 5% level or better has been found for drift velocity, longitudinal diffusion and transverse diffusion.

  17. Xenon Recovery at Room Temperature using Metal-Organic Frameworks

    Energy Technology Data Exchange (ETDEWEB)

    Elsaidi, Sameh K. [Physical and Computational Science Directorate, Pacific Northwest National Laboratory, Richland WA 99352 USA; Chemistry Department, Faculty of Science, Alexandria University, P. O. Box 426 Ibrahimia Alexandria 21321 Egypt; Ongari, Daniele [Laboratory of Molecular Simulation, Institut des Sciences et Ingeénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), Rue de l' Industrie 17 1951 Sion Valais Switzerland; Xu, Wenqian [X-ray Science Division, Advanced Photon Source, Argonne National Laboratory, Argonne IL 60439 USA; Mohamed, Mona H. [Chemistry Department, Faculty of Science, Alexandria University, P. O. Box 426 Ibrahimia Alexandria 21321 Egypt; Haranczyk, Maciej [IMDEA Materials Institute, c/Eric Kandel 2 28906 Getafe, Madrid Spain; Thallapally, Praveen K. [Physical and Computational Science Directorate, Pacific Northwest National Laboratory, Richland WA 99352 USA

    2017-07-24

    Xenon is known to be a very efficient anesthetic gas but its cost prohibits the wider use in medical industry and other potential applications. It has been shown that Xe recovery and recycle from anesthetic gas mixture can significantly reduce its cost as anesthetic. The current technology uses series of adsorbent columns followed by low temperature distillation to recover Xe, which is expensive to use in medical facilities. Herein, we propose much efficient and simpler system to recover and recycle Xe from simulant exhale anesthetic gas mixture at room temperature using metal organic frameworks. Among the MOFs tested, PCN-12 exhibits unprecedented performance with high Xe capacity, Xe/N2 and Xe/O2 selectivity at room temperature. The in-situ synchrotron measurements suggest the Xe is occupied in the small pockets of PCN-12 compared to unsaturated metal centers (UMCs). Computational modeling of adsorption further supports our experimental observation of Xe binding sites in PCN-12.

  18. Experimental Investigation from the Operation of a 2 kW Brayton Power Conversion Unit and a Xenon Ion Thruster

    Science.gov (United States)

    Hervol, David; Mason, Lee; Birchenough, Art; Pinero, Luis

    2004-01-01

    A 2kW Brayton Power Conversion Unit (PCU) and a xenon ion thruster were integrated with a Power Management and Distribution (PMAD) system as part of a Nuclear Electric Propulsion (NEP) Testbed at NASA's Glenn Research Center. Brayton Converters and ion thrusters are potential candidates for use on future high power NEP mission such as the proposed Jupiter Icy Moons Orbiter (JIMO). The use of a existing lower power test hardware provided a cost effective means to investigate the critical electrical interface between the power conversion system and the propulsion system. The testing successfully demonstrated compatible electrical operations between the converter and the thruster, including end-to-end electric power throughput, high efficiency AC to DC conversion, and thruster recycle fault protection. The details of this demonstration are reported herein.

  19. Experimental Investigations from the Operation of a 2 Kw Brayton Power Conversion Unit and a Xenon Ion Thruster

    Science.gov (United States)

    Mason, Lee; Birchenough, Arthur; Pinero, Luis

    2004-01-01

    A 2 kW Brayton Power Conversion Unit (PCU) and a xenon ion thruster were integrated with a Power Management and Distribution (PMAD) system as part of a Nuclear Electric Propulsion (NEP) Testbed at NASA's Glenn Research Center. Brayton converters and ion thrusters are potential candidates for use on future high power NEP missions such as the proposed Jupiter Icy Moons Orbiter (JIMO). The use of existing lower power test hardware provided a cost-effective means to investigate the critical electrical interface between the power conversion system and ion propulsion system. The testing successfully demonstrated compatible electrical operations between the converter and the thruster, including end-to-end electric power throughput, high efficiency AC to DC conversion, and thruster recycle fault protection. The details of this demonstration are reported herein.

  20. Development of a hyperpolarized 129Xe system on 3T for the rat lungs

    International Nuclear Information System (INIS)

    Sato, Hiroshi; Enmi, Jun-ichiro; Hayashi, Takuya

    2004-01-01

    MRI (magnetic resonance imaging) with 129 Xe has gained much attention as a diagnostic methodology because of its affinity for lipids and possible polarization. The quantitative estimation of net detectability and stability of hyperpolarized 129 Xe in the dissolved phase in vivo is valuable to the development of clinical applications. The goal of this study was to develop a stable hyperpolarized 129 Xe experimental 3T system to statistically analyze the dissolved-phase 129 Xe signal in the rat lungs. The polarization of 129 Xe with buffer gases at the optical pumping cell was measured under adiabatic fast passage against the temperature of an oven and laser absorption at the cell. The gases were insuffiated into the lungs of Sprague-Dawley rats (n=15, 400-550 g) through an endotracheal tube under spontaneous respiration. Frequency-selective spectroscopy was performed for the gas phase and dissolved phase. We analyzed the 129 Xe signal in the dissolved phase to measure the chemical shift, T 2 * , delay and its ratio in a rat lungs on 3T. The polarizer was able to produce polarized gas (1.1±0.47%, 120 cm 3 ) hundreds of times with the laser absorption ratio (25%) kept constant at the cell. The optimal buffer gas ratio of 25-50% rendered the maximum signal in the dissolved phase. Two dominant peaks of 211.8±0.9 and 201.1±0.6 ppm were observed with a delay of 0.4±0.9 and 0.9±1.0 s from the gas phase spectra. The ratios of their average signal to that of the gas phase were 5.6±5.2% and 4.4±4.7%, respectively. The T 2 * of the air space in the lungs was 2.5±0.5 ms, which was 3.8 times shorter than that in a syringe. We developed a hyperpolarized 129 Xe experimental system using a 3T MRI scanner that yields sufficient volume and polarization and quantitatively analyzed the dissolved-phase 129 Xe signal in the rat lungs. (author)

  1. Operation guide device for nuclear power plants

    International Nuclear Information System (INIS)

    Araki, Tsuneyasu

    1982-01-01

    Purpose: To enable to maintain the soundness of nuclear fuels and each of equipments by compensating the effect of the xenon density on the reactor core thermal power resulted upon load following operation of a nuclear reactor. Constitution: The device comprises an instrumentation system for measuring the status of the nuclear reactor, a reactor core performance calculator for calculating the reactor core performance based on the output from the instrumentation system, a xenon density calculator for calculating the xenon density based on the output from the performance calculator, a memory unit for storing the output from the reactor core performance calculator and the xenon density calculator and for transferring the stored memory to a nuclear reactor status forecasting device and an alternative load pattern searching device for searching, in cooperation with the memory unit, an alternative load pattern which is within an operation restrictive condition and most closed to a demanded load pattern when a monitor for the deviation from the flowrate distribution detects the deviation from the operation restrictive conditions. (Yoshino, Y.)

  2. Volumetric spiral chemical shift imaging of hyperpolarized [2-(13) c]pyruvate in a rat c6 glioma model.

    Science.gov (United States)

    Park, Jae Mo; Josan, Sonal; Jang, Taichang; Merchant, Milton; Watkins, Ron; Hurd, Ralph E; Recht, Lawrence D; Mayer, Dirk; Spielman, Daniel M

    2016-03-01

    MRS of hyperpolarized [2-(13)C]pyruvate can be used to assess multiple metabolic pathways within mitochondria as the (13)C label is not lost with the conversion of pyruvate to acetyl-CoA. This study presents the first MR spectroscopic imaging of hyperpolarized [2-(13)C]pyruvate in glioma-bearing brain. Spiral chemical shift imaging with spectrally undersampling scheme (1042 Hz) and a hard-pulse excitation was exploited to simultaneously image [2-(13)C]pyruvate, [2-(13)C]lactate, and [5-(13)C]glutamate, the metabolites known to be produced in brain after an injection of hyperpolarized [2-(13)C]pyruvate, without chemical shift displacement artifacts. A separate undersampling scheme (890 Hz) was also used to image [1-(13)C]acetyl-carnitine. Healthy and C6 glioma-implanted rat brains were imaged at baseline and after dichloroacetate administration, a drug that modulates pyruvate dehydrogenase kinase activity. The baseline metabolite maps showed higher lactate and lower glutamate in tumor as compared to normal-appearing brain. Dichloroacetate led to an increase in glutamate in both tumor and normal-appearing brain. Dichloroacetate-induced %-decrease of lactate/glutamate was comparable to the lactate/bicarbonate decrease from hyperpolarized [1-(13)C]pyruvate studies. Acetyl-carnitine was observed in the muscle/fat tissue surrounding the brain. Robust volumetric imaging with hyperpolarized [2-(13)C]pyruvate and downstream products was performed in glioma-bearing rat brains, demonstrating changes in mitochondrial metabolism with dichloroacetate. © 2015 Wiley Periodicals, Inc.

  3. Electron Impact Excitation Cross Sections of Xenon for Optical Plasma Diagnostic

    National Research Council Canada - National Science Library

    Srivastava, Rajesh

    2007-01-01

    In this project the researcher had taken up the calculation of xenon apparent emission-excitation cross sections for emission lines that have diagnostic value in the analysis of Xe-propelled electric thruster plasmas...

  4. Surface damage on polycrystalline β-SiC by xenon ion irradiation at high fluence

    Science.gov (United States)

    Baillet, J.; Gavarini, S.; Millard-Pinard, N.; Garnier, V.; Peaucelle, C.; Jaurand, X.; Duranti, A.; Bernard, C.; Rapegno, R.; Cardinal, S.; Escobar Sawa, L.; De Echave, T.; Lanfant, B.; Leconte, Y.

    2018-05-01

    Polycrystalline β-silicon carbide (β-SiC) pellets were prepared by Spark Plasma Sintering (SPS). These were implanted at room temperature with 800 keV xenon at ion fluences of 5.1015 and 1.1017 cm-2. Microstructural modifications were studied by electronic microscopy (TEM and SEM) and xenon profiles were determined by Rutherford Backscattering Spectroscopy (RBS). A complete amorphization of the implanted area associated with a significant oxidation is observed for the highest fluence. Large xenon bubbles formed in the oxide phase are responsible of surface swelling. No significant gas release has been measured up to 1017 at.cm-2. A model is proposed to explain the different steps of the oxidation process and xenon bubbles formation as a function of ion fluence.

  5. Monitoring xenon purity in the LUX detector with a mass spectrometry system

    Science.gov (United States)

    Balajthy, Jon; LUX Experiment Collaboration

    2015-04-01

    The LUX dark matter search experiment is a 350 kg two-phase liquid/gas xenon time projection chamber located at the 4850 ft level of the Sanford Underground Research Facility in Lead, SD. To monitor for radioactive impurities such as krypton and impurities which limit charge yield such as oxygen, LUX uses a xenon sampling system consisting of a mass spectrometer and a liquid nitrogen cold trap. The cold trap separates the gaseous impurities from a small sample of xenon and allows them to pass to the mass spectrometer for analysis. We report here on results from the LUX xenon sampling program. We also report on methods to enhance the sensitivity of the cold trap technique in preparation for the next-generation LUX-ZEPLIN experiment which will have even more stringent purity requirements.

  6. Recent developments in evaluating xenon induced flux transients in large HTRs

    Energy Technology Data Exchange (ETDEWEB)

    Lauer, A.

    1974-03-15

    A description is provided of the two-dimensional finite-difference xenon code system ASTERIX (A System for Transient Evaluation of Reactor instabilities Induced by Xenon) that was designed for very exact computations of space dependent xenon transients in HTR's and their control. By its modular structure, the code allows for a most flexible use in calculating load following transients, xenon oscillations in x/y, r/z and r/theta geometries and various control operations with either homogeneous poison or discrete rod representations with flux boundary conditions. The most recent upgrade ASTERIX-T includes a detailed temperature feedback option for azimuthal HTR transient calculations, based on an iterative procedure for the evaluation of the power distribution in each time step with succeeding diffusion, temperature and spectrum calculations for the group constants in every spectral region, thus avoiding earlier more problematic approximations of the temperature dependence of the cross sections.

  7. Experimental studies of a zeeman-tuned xenon laser differential absorption apparatus.

    Science.gov (United States)

    Linford, G J

    1973-06-01

    A Zeeman-tuned cw xenon laser differential absorption device is described. The xenon laser was tuned by axial magnetic fields up to 5500 G generated by an unusually large water-cooled dc solenoid. Xenon laser lines at 3.37 micro, 3.51 micro, and 3.99 micro were tuned over ranges of 6 A, 6 A, and 11 A, respectively. To date, this apparatus has been used principally to study the details of formaldehyde absorption lines lying near the 3 .508-micro xenon laser transition. These experiments revealed that the observed absorption spectrum of formaldehyde exhibits a sufficiently unique spectral structure that the present technique may readily be used to measure relative concentrations of formaldehyde in samples of polluted air.

  8. Postconditioning by xenon and hypothermia in the rat heart in vivo

    NARCIS (Netherlands)

    Schwiebert, Christian; Huhn, Ragnar; Heinen, Andre; Weber, Nina C.; Hollmann, Markus W.; Schlack, Wolfgang; Preckel, Benedikt

    2010-01-01

    Background and objective Hypothermia protects against myocardial reperfusion injury. However, inducing hypothermia takes time, which makes it unsuitable as an emergency treatment. Combining mild hypothermia with low-dose xenon, applied either simultaneously or one after the other, protects the

  9. Pulse Rise Time Characterization of a High Pressure Xenon Gamma Detector for use in Resolution Enhancement

    CERN Document Server

    Troyer, G L

    2000-01-01

    High pressure xenon ionization chamber detectors are possible alternatives to traditional thallium doped sodium iodide (NaI(Tl)) and hyperpure germanium as gamma spectrometers in certain applications. Xenon detectors incorporating a Frisch grid exhibit energy resolutions comparable to cadmium/zinc/telluride (CZT) (e.g. 2% (at) 662keV) but with far greater sensitive volumes. The Frisch grid reduces the position dependence of the anode pulse risetimes, but it also increases the detector vibration sensitivity, anode capacitance, voltage requirements and mechanical complexity. We have been investigating the possibility of eliminating the grid electrode in high-pressure xenon detectors and preserving the high energy resolution using electronic risetime compensation methods. A two-electrode cylindrical high pressure xenon gamma detector coupled to time-to-amplitude conversion electronics was used to characterize the pulse rise time of deposited gamma photons. Time discrimination was used to characterize the pulse r...

  10. Mobility and lifetime of sup 2 sup 0 sup 8 Tl ions in liquid xenon

    CERN Document Server

    Walters, A J

    2003-01-01

    Positively charged sup 2 sup 0 sup 8 Tl ions are transported through liquid xenon using electric fields in the range of 4-10 kV cm sup - sup 1 and for drift distances up to 50 mm. From these measurements we deduce upper limits on the attenuation length for Tl ions in liquid xenon, resulting in a lifetime >5.5 s. In addition to these results, the field independent mobility of Tl bearing species in liquid xenon was measured to be 1.33+-0.04x10 sup - sup 4 cm sup 2 V sup - sup 1 s sup - sup 1. This result, when coupled with those for other species by previous workers, suggests that positive ion mobility in liquid xenon is proportional to the hard-core radius. Applications to Ba ion collection in a double beta decay experiment are also discussed.

  11. Microscopic simulation of xenon-based optical TPCs in the presence of molecular additives

    Science.gov (United States)

    Azevedo, C. D. R.; González-Díaz, D.; Biagi, S. F.; Oliveira, C. A. B.; Henriques, C. A. O.; Escada, J.; Monrabal, F.; Gómez-Cadenas, J. J.; Álvarez, V.; Benlloch-Rodríguez, J. M.; Borges, F. I. G. M.; Botas, A.; Cárcel, S.; Carrión, J. V.; Cebrián, S.; Conde, C. A. N.; Díaz, J.; Diesburg, M.; Esteve, R.; Felkai, R.; Fernandes, L. M. P.; Ferrario, P.; Ferreira, A. L.; Freitas, E. D. C.; Goldschmidt, A.; Gutiérrez, R. M.; Hauptman, J.; Hernandez, A. I.; Morata, J. A. Hernando; Herrero, V.; Jones, B. J. P.; Labarga, L.; Laing, A.; Lebrun, P.; Liubarsky, I.; Lopez-March, N.; Losada, M.; Martín-Albo, J.; Martínez-Lema, G.; Martínez, A.; McDonald, A. D.; Monteiro, C. M. B.; Mora, F. J.; Moutinho, L. M.; Vidal, J. Muñoz; Musti, M.; Nebot-Guinot, M.; Novella, P.; Nygren, D.; Palmeiro, B.; Para, A.; Pérez, J.; Querol, M.; Renner, J.; Ripoll, L.; Rodríguez, J.; Rogers, L.; Santos, F. P.; dos Santos, J. M. F.; Serra, L.; Shuman, D.; Simón, A.; Sofka, C.; Sorel, M.; Stiegler, T.; Toledo, J. F.; Torrent, J.; Tsamalaidze, Z.; Veloso, J. F. C. A.; Webb, R.; White, J. T.; Yahlali, N.

    2018-01-01

    We introduce a simulation framework for the transport of high and low energy electrons in xenon-based optical time projection chambers (OTPCs). The simulation relies on elementary cross sections (electron-atom and electron-molecule) and incorporates, in order to compute the gas scintillation, the reaction/quenching rates (atom-atom and atom-molecule) of the first 41 excited states of xenon and the relevant associated excimers, together with their radiative cascade. The results compare positively with observations made in pure xenon and its mixtures with CO2 and CF4 in a range of pressures from 0.1 to 10 bar. This work sheds some light on the elementary processes responsible for the primary and secondary xenon-scintillation mechanisms in the presence of additives, that are of interest to the OTPC technology.

  12. Material radioassay and selection for the XENON1T dark matter experiment

    Energy Technology Data Exchange (ETDEWEB)

    Aprile, E.; Anthony, M.; De Perio, P.; Gao, F.; Goetzke, L.W.; Greene, Z.; Lin, Q.; Messina, M.; Plante, G.; Rizzo, A.; Zhang, Y. [Columbia University, Physics Department, New York, NY (United States); Aalbers, J.; Breur, P.A.; Brown, A.; Colijn, A.P.; Decowski, M.P.; Hogenbirk, E.; Tiseni, A. [Nikhef and the University of Amsterdam, Amsterdam (Netherlands); Agostini, F. [INFN-Laboratori Nazionali del Gran Sasso, L' Aquila (Italy); Gran Sasso Science Institute, L' Aquila (Italy); University of Bologna, Department of Physics and Astrophysics, Bologna (Italy); INFN-Bologna (Italy); Alfonsi, M.; Geis, C.; Grignon, C.; Oberlack, U.; Scheibelhut, M.; Schindler, S. [Johannes Gutenberg-Universitaet Mainz, Institut fuer Physik and Exzellenzcluster PRISMA, Mainz (Germany); Amaro, F.D.; Cardoso, J.M.R.; Lopes, J.A.M.; Santos, J.M.F. dos; Silva, M. [University of Coimbra, LIBPhys, Department of Physics, Coimbra (Portugal); Arneodo, F.; Benabderrahmane, M.L.; Maris, I. [New York University Abu Dhabi, Abu Dhabi (United Arab Emirates); Barrow, P.; Baudis, L.; Di Giovanni, A.; Franco, D.; Galloway, M.; Kessler, G.; Kish, A.; Mayani, D.; Pakarha, P.; Piastra, F.; Wei, Y.; Wulf, J. [University of Zurich, Physik Institut, Zurich (Switzerland); Bauermeister, B. [Johannes Gutenberg-Universitaet Mainz, Institut fuer Physik and Exzellenzcluster PRISMA, Mainz (Germany); Stockholm University, AlbaNova, Oskar Klein Centre, Department of Physics, Stockholm (Sweden); Berger, T.; Brown, E.; Piro, M.C. [Rensselaer Polytechnic Institute, Department of Physics, Applied Physics and Astronomy, Troy, NY (United States); Sivers, M. von [Rensselaer Polytechnic Institute, Troy, NY (United States). Dept. of Physics, Applied Physics and Astronomy; Bern Univ. (Switzerland). Albert Einstein Center for Fundamental Physics; Bruenner, S.; Cichon, D.; Eurin, G.; Hasterok, C.; Lindemann, S.; Lindner, M.; Marrodan Undagoitia, T.; Pizzella, V.; Rauch, L.; Rupp, N.; Schreiner, J.; Simgen, H. [Max-Planck-Institut fuer Kernphysik, Heidelberg (Germany); Bruno, G.; Gallo Rosso, A.; Molinario, A.; Laubenstein, M.; Nisi, S. [INFN-Laboratori Nazionali del Gran Sasso, L' Aquila (Italy); Gran Sasso Science Institute, L' Aquila (Italy); Budnik, R.; Itay, R.; Landsman, H.; Lellouch, D.; Levinson, L.; Manfredini, A.; Priel, N. [Weizmann Institute of Science, Department of Particle Physics and Astrophysics, Rehovot (Israel); Buetikofer, L.; Coderre, D.; Kaminsky, B.; Schumann, M. [Universitaet Freiburg, Physikalisches Institut, Freiburg (Germany); Calven, J.; Conrad, J.; Ferella, A.D.; Pelssers, B. [Stockholm University, AlbaNova, Oskar Klein Centre, Department of Physics, Stockholm (Sweden); Cervantes, M.; Lang, R.F.; Masson, D.; Pienaar, J.; Reichard, S.; Reuter, C. [Purdue University, Department of Physics and Astronomy, West Lafayette, IN (United States); Cussonneau, J.P.; Diglio, S.; Le Calloch, M.; Masbou, J.; Micheneau, K.; Persiani, R.; Thers, D. [Universite de Nantes, SUBATECH, Ecole des Mines de Nantes, CNRS/IN2P3, Nantes (France); Di Gangi, P.; Garbini, M.; Massoli, F.V.; Sartorelli, G.; Selvi, M. [University of Bologna, Department of Physics and Astrophysics, Bologna (Italy); INFN-Bologna (Italy); Fei, J.; Ni, K.; Ye, J. [University of California, Department of Physics, San Diego, CA (United States); Fieguth, A.; Murra, M.; Rosendahl, S.; Weinheimer, C. [Westfaelische Wilhelms-Universitaet Muenster, Institut fuer Kernphysik, Muenster (Germany); Fulgione, W. [INFN-Laboratori Nazionali del Gran Sasso, L' Aquila (Italy); Gran Sasso Science Institute, L' Aquila (Italy); INFN-Torino (Italy); Osservatorio Astrofisico di Torino, Torino (Italy); Grandi, L.; Saldanha, R.; Shockley, E.; Upole, N. [University of Chicago, Department of Physics and Kavli Institute of Cosmological Physics, Chicago, IL (United States); Miguez, B.; Trinchero, G. [INFN-Torino (Italy); Osservatorio Astrofisico di Torino, Torino (Italy); Naganoma, J.; Shagin, P. [Rice University, Department of Physics and Astronomy, Houston, TX (United States); Scotto Lavina, L. [Universite Pierre et Marie Curie, Universite Paris Diderot, CNRS/IN2P3, LPNHE, Paris (France); Stein, A.; Wang, H. [University of California, Physics and Astronomy Department, Los Angeles, CA (United States); Tunnell, C. [Nikhef and the University of Amsterdam, Amsterdam (Netherlands); University of Chicago, Department of Physics and Kavli Institute of Cosmological Physics, Chicago, IL (United States); Collaboration: XENON Collaboration

    2017-12-15

    The XENON1T dark matter experiment aims to detect weakly interacting massive particles (WIMPs) through low-energy interactions with xenon atoms. To detect such a rare event necessitates the use of radiopure materials to minimize the number of background events within the expected WIMP signal region. In this paper we report the results of an extensive material radioassay campaign for the XENON1T experiment. Using gamma-ray spectroscopy and mass spectrometry techniques, systematic measurements of trace radioactive impurities in over one hundred samples within a wide range of materials were performed. The measured activities allowed for stringent selection and placement of materials during the detector construction phase and provided the input for XENON1T detection sensitivity estimates through Monte Carlo simulations. (orig.)

  13. Measuring glucose cerebral metabolism in the healthy mouse using hyperpolarized C-13 magnetic resonance

    DEFF Research Database (Denmark)

    Mishkovsky, Mor; Anderson, Brian; Karlsson, Magnus

    2017-01-01

    The mammalian brain relies primarily on glucose as a fuel to meet its high metabolic demand. Among the various techniques used to study cerebral metabolism, C-13 magnetic resonance spectroscopy (MRS) allows following the fate of C-13-enriched substrates through metabolic pathways. We herein...... glucose is split into 3-carbon intermediates by aldolase. This unique method allows direct detection of glycolysis in vivo in the healthy brain in a noninvasive manner....... demonstrate that it is possible to measure cerebral glucose metabolism in vivo with sub-second time resolution using hyperpolarized C-13 MRS. In particular, the dynamic C-13-labeling of pyruvate and lactate formed from C-13-glucose was observed in real time. An ad-hoc synthesis to produce [2,3,4,6,6-H-2(5), 3...

  14. Effects of anesthesia on renal function and metabolism in rats assessed by hyperpolarized MRI

    DEFF Research Database (Denmark)

    Qi, Haiyun; Mariager, Christian Østergaard; Lindhardt, Jakob

    2018-01-01

    . In the present study, we aimed to investigate the renal functional and metabolic consequences of 3 typical rodent anesthetics used in preclinical MRI: sevoflurane, inaction, and a mixture of fentanyl, fluanisone, and midazolam (FFM). METHODS: The renal effects of 3 different classes of anesthetics (inactin......, servoflurane, and FFM) were investigated using functional and metabolic MRI. The renal glucose metabolism and hemodynamics was characterized with hyperpolarized [1-13C]pyruvate MRI and by DCE imaging. RESULTS: Rats receiving sevoflurane or FFM had blood glucose levels that were 1.3-fold to 1.4-fold higher than...... rats receiving inactin. A 2.9-fold and 4.8-fold increased13C-lactate/13C-pyruvate ratio was found in the FFM mixture anesthetized group compared with the sevoflurane and the inactin anesthetized groups. The FFM anesthesia resulted in a 50% lower renal plasma flow compared with the sevoflurane...

  15. Acute renal metabolic effect of metformin treatment assessed with hyperpolarized magnetic resonance imaging

    DEFF Research Database (Denmark)

    Qi, Haiyun; Nielsen, Per Mose; Schroeder, Marie

    2017-01-01

    Metformin is the primary anti-diabetic drug in type-2 diabetes patients. However, controversy exists on its use in patients with renal impairment. Here we investigated the acute metabolic effects of metformin treatment in rat kidneys, with hyperpolarized 13C pyruvate and Clark......-electrodes. A significantly altered metabolic phenotype was observed 30 min post metformin treatment. Anaerobic metabolism was elevated in the cytosol, indicated by increased lactate/pyruvate ratio, and mitochondrial aerobic metabolism was reduced, indicated by decreased bicarbonate/pyruvate ratio. Acute metformin treatment...... increased renal blood flow with higher O2 saturation and did not change tubular O2 consumption. These results indicate that metformin reduces mitochondrial respiration and enhances anaerobic metabolism, even with enough oxygen supply, within only 30 min of treatment....

  16. Post-Test Inspection of Nasa's Evolutionary Xenon Thruster Long Duration Test Hardware: Ion Optics

    Science.gov (United States)

    Soulas, George C.; Shastry, Rohit

    2016-01-01

    A Long Duration Test (LDT) was initiated in June 2005 as a part of NASAs Evolutionary Xenon Thruster (NEXT) service life validation approach. Testing was voluntarily terminated in February 2014, with the thruster accumulating 51,184 hours of operation, processing 918 kg of xenon propellant, and delivering 35.5 MN-s of total impulse. This presentation will present the post-test inspection results to date for the thrusters ion optics.

  17. Time dependent analysis of Xenon spatial oscillations in small power reactors

    International Nuclear Information System (INIS)

    Decco, Claudia Cristina Ghirardello

    1997-01-01

    This work presents time dependent analysis of xenon spatial oscillations studying the influence of the power density distribution, type of reactivity perturbation, power level and core size, using the one-dimensional and three-dimensional analysis with the MID2 and citation codes, respectively. It is concluded that small pressurized water reactors with height smaller than 1.5 m are stable and do not have xenon spatial oscillations. (author)

  18. Can pulsed xenon ultraviolet light systems disinfect aerobic bacteria in the absence of manual disinfection?

    Science.gov (United States)

    Jinadatha, Chetan; Villamaria, Frank C; Ganachari-Mallappa, Nagaraja; Brown, Donna S; Liao, I-Chia; Stock, Eileen M; Copeland, Laurel A; Zeber, John E

    2015-04-01

    Whereas pulsed xenon-based ultraviolet light no-touch disinfection systems are being increasingly used for room disinfection after patient discharge with manual cleaning, their effectiveness in the absence of manual disinfection has not been previously evaluated. Our study indicates that pulsed xenon-based ultraviolet light systems effectively reduce aerobic bacteria in the absence of manual disinfection. These data are important for hospitals planning to adopt this technology as adjunct to routine manual disinfection. Published by Elsevier Inc.

  19. Regional alveolar partial pressure of oxygen measurement with parallel accelerated hyperpolarized gas MRI.

    Science.gov (United States)

    Kadlecek, Stephen; Hamedani, Hooman; Xu, Yinan; Emami, Kiarash; Xin, Yi; Ishii, Masaru; Rizi, Rahim

    2013-10-01

    Alveolar oxygen tension (Pao2) is sensitive to the interplay between local ventilation, perfusion, and alveolar-capillary membrane permeability, and thus reflects physiologic heterogeneity of healthy and diseased lung function. Several hyperpolarized helium ((3)He) magnetic resonance imaging (MRI)-based Pao2 mapping techniques have been reported, and considerable effort has gone toward reducing Pao2 measurement error. We present a new Pao2 imaging scheme, using parallel accelerated MRI, which significantly reduces measurement error. The proposed Pao2 mapping scheme was computer-simulated and was tested on both phantoms and five human subjects. Where possible, correspondence between actual local oxygen concentration and derived values was assessed for both bias (deviation from the true mean) and imaging artifact (deviation from the true spatial distribution). Phantom experiments demonstrated a significantly reduced coefficient of variation using the accelerated scheme. Simulation results support this observation and predict that correspondence between the true spatial distribution and the derived map is always superior using the accelerated scheme, although the improvement becomes less significant as the signal-to-noise ratio increases. Paired measurements in the human subjects, comparing accelerated and fully sampled schemes, show a reduced Pao2 distribution width for 41 of 46 slices. In contrast to proton MRI, acceleration of hyperpolarized imaging has no signal-to-noise penalty; its use in Pao2 measurement is therefore always beneficial. Comparison of multiple schemes shows that the benefit arises from a longer time-base during which oxygen-induced depolarization modifies the signal strength. Demonstration of the accelerated technique in human studies shows the feasibility of the method and suggests that measurement error is reduced here as well, particularly at low signal-to-noise levels. Copyright © 2013 AUR. Published by Elsevier Inc. All rights reserved.

  20. Cell-Type Specific Development of the Hyperpolarization-Activated Current, Ih, in Prefrontal Cortical Neurons

    Directory of Open Access Journals (Sweden)

    Sha-Sha Yang

    2018-05-01

    Full Text Available H-current, also known as hyperpolarization-activated current (Ih, is an inward current generated by the hyperpolarization-activated cyclic nucleotide-gated (HCN cation channels. Ih plays an essential role in regulating neuronal properties, synaptic integration and plasticity, and synchronous activity in the brain. As these biological factors change across development, the brain undergoes varying levels of vulnerability to disorders like schizophrenia that disrupt prefrontal cortex (PFC-dependent function. However, developmental changes in Ih in PFC neurons remains untested. Here, we examine Ih in pyramidal neurons vs. gamma-aminobutyric acid (GABAergic parvalbumin-expressing (PV+ interneurons in developing mouse PFC. Our findings show that the amplitudes of Ih in these cell types are identical during the juvenile period but differ at later time points. In pyramidal neurons, Ih amplitude significantly increases from juvenile to adolescence and follows a similar trend into adulthood. In contrast, the amplitude of Ih in PV+ interneurons decreases from juvenile to adolescence, and does not change from adolescence to adulthood. Moreover, the kinetics of HCN channels in pyramidal neurons is significantly slower than in PV+ interneurons, with a gradual decrease in pyramidal neurons and a gradual increase in PV+ cells across development. Our study reveals distinct developmental trajectories of Ih in pyramidal neurons and PV+ interneurons. The cell-type specific alteration of Ih during the critical period from juvenile to adolescence reflects the contribution of Ih to the maturation of the PFC and PFC-dependent function. These findings are essential for a better understanding of normal PFC function, and for elucidating Ih’s crucial role in the pathophysiology of neurodevelopmental disorders.

  1. ACh-induced hyperpolarization and decreased resistance in mammalian type II vestibular hair cells.

    Science.gov (United States)

    Poppi, Lauren A; Tabatabaee, Hessam; Drury, Hannah R; Jobling, Phillip; Callister, Robert J; Migliaccio, Americo A; Jordan, Paivi M; Holt, Joseph C; Rabbitt, Richard D; Lim, Rebecca; Brichta, Alan M

    2018-01-01

    In the mammalian vestibular periphery, electrical activation of the efferent vestibular system (EVS) has two effects on afferent activity: 1) it increases background afferent discharge and 2) decreases afferent sensitivity to rotational stimuli. Although the cellular mechanisms underlying these two contrasting afferent responses remain obscure, we postulated that the reduction in afferent sensitivity was attributed, in part, to the activation of α9- containing nicotinic acetylcholine (ACh) receptors (α9*nAChRs) and small-conductance potassium channels (SK) in vestibular type II hair cells, as demonstrated in the peripheral vestibular system of other vertebrates. To test this hypothesis, we examined the effects of the predominant EVS neurotransmitter ACh on vestibular type II hair cells from wild-type (wt) and α9-subunit nAChR knockout (α9 -/- ) mice. Immunostaining for choline acetyltransferase revealed there were no obvious gross morphological differences in the peripheral EVS innervation among any of these strains. ACh application onto wt type II hair cells, at resting potentials, produced a fast inward current followed by a slower outward current, resulting in membrane hyperpolarization and decreased membrane resistance. Hyperpolarization and decreased resistance were due to gating of SK channels. Consistent with activation of α9*nAChRs and SK channels, these ACh-sensitive currents were antagonized by the α9*nAChR blocker strychnine and SK blockers apamin and tamapin. Type II hair cells from α9 -/- mice, however, failed to respond to ACh at all. These results confirm the critical importance of α9nAChRs in efferent modulation of mammalian type II vestibular hair cells. Application of exogenous ACh reduces electrical impedance, thereby decreasing type II hair cell sensitivity. NEW & NOTEWORTHY Expression of α9 nicotinic subunit was crucial for fast cholinergic modulation of mammalian vestibular type II hair cells. These findings show a multifaceted

  2. Hyperpolarized 3He magnetic resonance imaging: Preliminary evaluation of phenotyping potential in chronic obstructive pulmonary disease

    International Nuclear Information System (INIS)

    Mathew, Lindsay; Kirby, Miranda; Etemad-Rezai, Roya; Wheatley, Andrew; McCormack, David G.; Parraga, Grace

    2011-01-01

    Rationale and objectives: Emphysema and small airway obstruction are the pathological hallmarks of chronic obstructive pulmonary disease (COPD). The aim of this pilot study in a small group of chronic obstructive pulmonary disease (COPD) patients was to quantify hyperpolarized helium-3 ( 3 He) magnetic resonance imaging (MRI) functional and structural measurements and to explore the potential role for 3 He MRI in detecting the lung structural and functional COPD phenotypes. Materials and methods: We evaluated 20 ex-smokers with stage I (n = 1), stage II (n = 9) and stage III COPD (n = 10). All subjects underwent same-day plethysmography, spirometry, 1 H MRI and hyperpolarized 3 He MRI at 3.0 T. 3 He ventilation defect percent (VDP) was generated from 3 He static ventilation images and 1 H thoracic images and the 3 He apparent diffusion coefficient (ADC) was derived from diffusion-weighted MRI. Results: Based on the relative contribution of normalized ADC and VDP, there was evidence of a predominant 3 He MRI measurement in seven patients (n = 3 mainly ventilation defects or VDP dominant (VD), n = 4 mainly increased ADC or ADC dominant (AD)). Analysis of variance (ANOVA) showed significantly lower ADC for subjects with predominantly elevated VDP (p = 0.02 compared to subjects with predominantly elevated ADC; p = 0.008 compared to mixed group) and significantly decreased VDP for subjects with predominantly elevated ADC (p = 0.003, compared to mixed group). Conclusion: In this small pilot study, a preliminary analysis shows the potential for 3 He MRI to categorize or phenotype COPD ex-smokers, providing good evidence of feasibility for larger prospective studies.

  3. Mis-estimation and bias of hyperpolarized apparent diffusion coefficient measurements due to slice profile effects.

    Science.gov (United States)

    Gordon, Jeremy W; Milshteyn, Eugene; Marco-Rius, Irene; Ohliger, Michael; Vigneron, Daniel B; Larson, Peder E Z

    2017-09-01

    The purpose of this work was to explore the impact of slice profile effects on apparent diffusion coefficient (ADC) mapping of hyperpolarized (HP) substrates. Slice profile effects were simulated using a Gaussian radiofrequency (RF) pulse with a variety of flip angle schedules and b-value ordering schemes. A long T 1 water phantom was used to validate the simulation results, and ADC mapping of HP [ 13 C, 15 N 2 ]urea was performed on the murine liver to assess these effects in vivo. Slice profile effects result in excess signal after repeated RF pulses, causing bias in HP measurements. The largest error occurs for metabolites with small ADCs, resulting in up to 10-fold overestimation for metabolites that are in more-restricted environments. A mixed b-value scheme substantially reduces this bias, whereas scaling the slice-select gradient can mitigate it completely. In vivo, the liver ADC of hyperpolarized [ 13 C, 15 N 2 ]urea is nearly 70% lower (0.99 ± 0.22 vs 1.69 ± 0.21 × 10 -3 mm 2 /s) when slice-select gradient scaling is used. Slice profile effects can lead to bias in HP ADC measurements. A mixed b-value ordering scheme can reduce this bias compared to sequential b-value ordering. Slice-select gradient scaling can also correct for this deviation, minimizing bias and providing more-precise ADC measurements of HP substrates. Magn Reson Med 78:1087-1092, 2017. © 2016 International Society for Magnetic Resonance in Medicine. © 2016 International Society for Magnetic Resonance in Medicine.

  4. Design and commissioning of ReStoX for XENON1T

    Energy Technology Data Exchange (ETDEWEB)

    Scheibelhut, Melanie [Institut fuer Physik, Johannes Gutenberg Universitaet Mainz (Germany)

    2015-07-01

    The XENON1T experiment, currently under construction at the Gran Sasso underground laboratory LNGS, uses the concept of a xenon dual-phase (liquid/gas) time projection chamber to search for Dark Matter particles. This requires cooling to about 175 K and liquefaction of the noble gas. The ReStoX (Recovery and Storage of Xenon) is a novel device to store and recover up to 7 tons of xenon - either in liquid phase at cryogenic temperatures and 1-2 bar of pressure, or in gaseous form at room temperature at about 70 bar of pressure. The ReStoX system consists of a double insulated stainless steel sphere with liquid nitrogen cooling loops distributed across the inner sphere. A condenser on the inside, also operated with liquid nitrogen, provides a cooling power of 3 kW. ReStoX is designed to provide an effective means for various operating modes: to fill the TPC fast, to recover xenon from the TPC under normal and emergency conditions, to store xenon safely in liquid or gaseous form, or to remain in cold standby nearly empty as a safety device. Here we present the design and first commissioning results.

  5. Isotopic composition of primary xenon and the fission of Pu-244

    Energy Technology Data Exchange (ETDEWEB)

    Levskii, L K

    1983-05-01

    The hypothesis that the origin of xenon on earth is due to the fission of uranium and/or transuranium elements is examined. The isotopic composition of primary xenon on earth is calculated using a model (Levskii, 1980) of the isotopic composition of rare gases which is based on the hypothesis of the heterogeneity of the isotopic composition of the elements of the solar system. The isotopic composition of fission-produced xenon in the atmosphere and solid earth is determined to correspond to the abundance of xenon isotopes as a result of the spontaneous fission of Pu-244 (half-life of 8.2 x 10 to the 7th years). The amount of fission-produced xenon in the atmosphere is shown to amount to about 30 percent (Xe-136). Under certain conditions, the degree of the degassing of the solid earth for xenon is 25 percent, which corresponds to a ratio of Kr-84/Xe-130 45 for the earth as a whole.

  6. Control of spatial xenon oscillations in pressurized water reactors via the Kalman filter

    International Nuclear Information System (INIS)

    Lin, C.; Lin, Y.J.

    1994-01-01

    A direct control method is developed to control the spatial xenon oscillations in pressurized water reactors. The xenon and iodine concentration difference between the top and bottom halves of the core is estimated by using the extended Kalman filter (EKF), which is a closed-loop estimation method. The measurement equation used in the observer is the axial offset measurement equation, which reflects the xenon unbalanced effect on the axial offset. Meanwhile, some of the coefficients of the observer are estimated on-line to reduce estimation error resulting from model error, i.e., simplified xenon and iodine dynamics. Therefore, the estimation can be guaranteed to be accurate, and the success of the estimation does not greatly depend on the accuracy of the observer model. The predicted one-step ahead xenon concentration, by using the EKF, was used to calculate the possible axial offset variation, and then the control rod motion was calculated to compensate for it. The simulation results show that the proposed method successfully controls the xenon oscillations

  7. Design and construction of a cryogenic distillation device for removal of krypton for liquid xenon dark matter detectors.

    Science.gov (United States)

    Wang, Zhou; Bao, Lei; Hao, Xihuan; Ju, Yonglin

    2014-01-01

    Liquid xenon (Xe) is one of the commendable detecting media for the dark matter detections. However, the small content of radioactive krypton-85 ((85)Kr) always exists in the commercial xenon products. An efficient cryogenic distillation system to remove this krypton (Kr) from commercial xenon products has been specifically designed, developed, and constructed in order to meet the requirements of the dark matter experiments with high- sensitivity and low-background. The content of krypton in regular commercial xenon products can be reduced from 10(-9) to 10(-12), with 99% xenon collection efficiency at maximum flow rate of 5 kg/h (15SLPM). The purified xenon gases produced by this distillation system can be used as the detecting media in the project of Panda X, which is the first dark matter detector developed in China.

  8. Dynamic nuclear polarization and optimal control spatial-selective 13C MRI and MRS

    DEFF Research Database (Denmark)

    Vinding, Mads Sloth; Laustsen, Christoffer; Maximov, Ivan I.

    2013-01-01

    . This is achieved through the development of spatial-selective single-shot spiral-readout MRI and MRS experiments combined with dynamic nuclear polarization hyperpolarized [1-13C]pyruvate on a 4.7T pre-clinical MR scanner. The method stands out from related techniques by facilitating anatomic shaped region...

  9. Effect of heavy atoms on photochemically induced dynamic nuclear polarization in liquids

    Science.gov (United States)

    Okuno, Yusuke; Cavagnero, Silvia

    2018-01-01

    Given its short hyperpolarization time (∼10-6 s) and mostly non-perturbative nature, photo-chemically induced dynamic nuclear polarization (photo-CIDNP) is a powerful tool for sensitivity enhancement in nuclear magnetic resonance. In this study, we explore the extent of 1H-detected 13C nuclear hyperpolarization that can be gained via photo-CIDNP in the presence of small-molecule additives containing a heavy atom. The underlying rationale for this methodology is the well-known external-heavy-atom (EHA) effect, which leads to significant enhancements in the intersystem-crossing rate of selected photosensitizer dyes from photoexcited singlet to triplet. We exploited the EHA effect upon addition of moderate amounts of halogen-atom-containing cosolutes. The resulting increase in the transient triplet-state population of the photo-CIDNP sensitizer fluorescein resulted in a significant increase in the nuclear hyperpolarization achievable via photo-CIDNP in liquids. We also explored the internal-heavy-atom (IHA) effect, which is mediated by halogen atoms covalently incorporated into the photosensitizer dye. Widely different outcomes were achieved in the case of EHA and IHA, with EHA being largely preferable in terms of net hyperpolarization.

  10. A system for accurate and automated injection of hyperpolarized substrate with minimal dead time and scalable volumes over a large range

    Science.gov (United States)

    Reynolds, Steven; Bucur, Adriana; Port, Michael; Alizadeh, Tooba; Kazan, Samira M.; Tozer, Gillian M.; Paley, Martyn N. J.

    2014-02-01

    Over recent years hyperpolarization by dissolution dynamic nuclear polarization has become an established technique for studying metabolism in vivo in animal models. Temporal signal plots obtained from the injected metabolite and daughter products, e.g. pyruvate and lactate, can be fitted to compartmental models to estimate kinetic rate constants. Modeling and physiological parameter estimation can be made more robust by consistent and reproducible injections through automation. An injection system previously developed by us was limited in the injectable volume to between 0.6 and 2.4 ml and injection was delayed due to a required syringe filling step. An improved MR-compatible injector system has been developed that measures the pH of injected substrate, uses flow control to reduce dead volume within the injection cannula and can be operated over a larger volume range. The delay time to injection has been minimized by removing the syringe filling step by use of a peristaltic pump. For 100 μl to 10.000 ml, the volume range typically used for mice to rabbits, the average delivered volume was 97.8% of the demand volume. The standard deviation of delivered volumes was 7 μl for 100 μl and 20 μl for 10.000 ml demand volumes (mean S.D. was 9 ul in this range). In three repeat injections through a fixed 0.96 mm O.D. tube the coefficient of variation for the area under the curve was 2%. For in vivo injections of hyperpolarized pyruvate in tumor-bearing rats, signal was first detected in the input femoral vein cannula at 3-4 s post-injection trigger signal and at 9-12 s in tumor tissue. The pH of the injected pyruvate was 7.1 ± 0.3 (mean ± S.D., n = 10). For small injection volumes, e.g. less than 100 μl, the internal diameter of the tubing contained within the peristaltic pump could be reduced to improve accuracy. Larger injection volumes are limited only by the size of the receiving vessel connected to the pump.

  11. Collateral Ventilation to Congenital Hyperlucent Lung Lesions Assessed on Xenon-Enhanced Dynamic Dual-Energy CT: an Initial Experience

    OpenAIRE

    Goo, Hyun Woo; Yang, Dong Hyun; Kim, Namkug; Park, Seung Il; Kim, Dong Kwan; Kim, Ellen Ai-Rhan

    2011-01-01

    Objective We wanted to evaluate the resistance to collateral ventilation in congenital hyperlucent lung lesions and to correlate that with the anatomic findings on xenon-enhanced dynamic dual-energy CT. Materials and Methods Xenon-enhanced dynamic dual-energy CT was successfully and safely performed in eight children (median age: 5.5 years, 4 boys and 4 girls) with congenital hyperlucent lung lesions. Functional assessment of the lung lesions on the xenon map was done, including performing a ...

  12. Nuclear

    International Nuclear Information System (INIS)

    Anon.

    2000-01-01

    The first text deals with a new circular concerning the collect of the medicine radioactive wastes, containing radium. This campaign wants to incite people to let go their radioactive wastes (needles, tubes) in order to suppress any danger. The second text presents a decree of the 31 december 1999, relative to the limitations of noise and external risks resulting from the nuclear facilities exploitation: noise, atmospheric pollution, water pollution, wastes management and fire prevention. (A.L.B.)

  13. Simulation of pulsed dielectric barrier discharge xenon excimer lamp

    International Nuclear Information System (INIS)

    Bogdanov, E A; Kudryavtsev, A A; Arslanbekov, R R; Kolobov, V I

    2004-01-01

    Recently, it has been shown that the efficiency of excimer lamps can be drastically increased in a pulsed regime. A one-dimensional simulation of pulsed excimer lamps has been performed by Carman and Mildren (2003 J. Phys. D: Appl. Phys. 36 19) (C and M). However, some computational results of the work of C and M are questionable and need to be revisited. In this paper, a dielectric barrier discharge (DBD) in xenon has been simulated for operating conditions similar to those of C and M to better understand plasma dynamics in a pulsed regime. Our simulation results differ considerably from the computational results of C and M. Although these differences do not affect profoundly the plasma macro parameters measured in the C and M experiments, they offer a better understanding of plasma dynamics in pulsed DBDs and form a solid foundation for computational optimization of excimer lamps. It was found that the dynamics of breakdown and the current pulse depend significantly on the initial densities of species after a previous pulse, and so it is important to accurately simulate the plasma evolution in both the afterglow and active stages. It seems possible to modify the power deposition in the plasma by varying external discharge parameters such as the amplitude and the rise time of the applied voltage, and to modify the plasma composition by changing the pulse repetition rate and plasma decay in the afterglow stage

  14. Compressible Convection Experiment using Xenon Gas in a Centrifuge

    Science.gov (United States)

    Menaut, R.; Alboussiere, T.; Corre, Y.; Huguet, L.; Labrosse, S.; Deguen, R.; Moulin, M.

    2017-12-01

    We present here an experiment especially designed to study compressible convection in the lab. For significant compressible convection effects, the parameters of the experiment have to be optimized: we use xenon gaz in a cubic cell. This cell is placed in a centrifuge to artificially increase the apparent gravity and heated from below. With these choices, we are able to reach a dissipation number close to Earth's outer core value. We will present our results for different heating fluxes and rotation rates. We success to observe an adiabatic gradient of 3K/cm in the cell. Studies of pressure and temperature fluctuations lead us to think that the convection takes place under the form of a single roll in the cell for high heating flux. Moreover, these fluctuations show that the flow is geostrophic due to the high rotation speed. This important role of rotation, via Coriolis force effects, in our experimental setup leads us to develop a 2D quasigeostrophic compressible model in the anelastic liquid approximation. We test numerically this model with the finite element solver FreeFem++ and compare its results with our experimental data. In conclusion, we will present our project for the next experiment in which the cubic cell will be replace by a annulus cell. We will discuss the new expected effects due to this geometry as Rossby waves and zonal flows.

  15. Multiphoton ionization photoelectron spectroscopy of xenon: Experiment and theory

    International Nuclear Information System (INIS)

    Bajic, S.J.; Compton, R.N.; Tang, X.; L'Huiller, A.; Lambropoulos, P.

    1988-11-01

    Photoelectron energy and angular distributions for resonantly enhanced multiphoton ionization (REMPI) of xenon via the three-photon-allowed 7s[3/2] 1 0 and 5d[3/2] 1 0 states have been studied both experimentally and theoretically. The electron kinetic energy spectra give the probability of leaving Xe + in either the 2 P/sub 1/2/ or 2 P/sub 3/2/ core. The measured branching ratio for leaving each ionic core is used to test the theoretical description of the REMPI process. Measurements of both the angular distributions and the [3+1] REMPI via the 5d state are adequately reproduced by multichannel quantum defect theory. However, measurements of angular distributions for the electrons resulting from [3+1] via the 7s[3/2] 1 0 state into Xe + 2 P/sub 3/2/ (core preserving) or Xe + 2 P/sub 1/2/ (core changing) are in striking disagreement with theory. 1 ref., 2 figs

  16. Self-organization in cathode boundary layer discharges in xenon

    International Nuclear Information System (INIS)

    Takano, Nobuhiko; Schoenbach, Karl H

    2006-01-01

    Self-organization of direct current xenon microdischarges in cathode boundary layer configuration has been studied for pressures in the range 30-140 Torr and for currents in the range 50 μA-1 mA. Side-on and end-on observations of the discharge have provided information on the structure and spatial arrangement of the plasma filaments. The regularly spaced filaments, which appear in the normal glow mode when the current is lowered, have a length which is determined by the cathode fall. It varies, dependent on pressure and current, between 50 and 70 μm. The minimum diameter is approximately 80 μm, as determined from the radiative emission in the visible. The filaments are sources of extensive excimer emission. Measurements of the cathode fall length have allowed us to determine the secondary emission coefficient for the discharge in the normal glow mode and to estimate the cathode fall voltage at the transition from normal glow mode to filamentary mode. It was found that the cathode fall voltage at this transition decreases, indicating the onset of additional electron gain processes at the cathode. The regular arrangement of the filaments, self-organization, is assumed to be due to Coulomb interactions between the positively charged cathode fall channels and positive space charges on the surface of the surrounding dielectric spacer. Calculations based on these assumptions showed good agreement with experimentally observed filament patterns

  17. First Detection of Krypton and Xenon in a White Dwarf

    Science.gov (United States)

    Werner, Klaus; Rauch, Thomas; Ringat, Ellen; Kruk, Jeffrey W.

    2012-01-01

    We report on the first detection of the noble gases krypton (Z = 36) and xenon (54) in a white dwarf. About 20 KrVI-VII and Xe VI-VII lines were discovered in the ultraviolet spectrum of the hot DO-type white dwarf RE 0503-289. The observations, performed with the Far Ultraviolet Spectroscopic Explorer, also reveal highly ionized photospheric lines from other trans-iron group elements, namely Ga (31), Ge (32), As (33), Se (34), Mo (42), Sn (50), Te (52), and I (53), from which gallium and molybdenum are new discoveries in white dwarfs, too. For Kr and Xe, we performed an NLTE analysis and derived mass fractions of log Kr = -4.3 plus or minus 0.5 and log Xe = -4.2 plus or minus 0.6, corresponding to an enrichment by factors of 450 and 3800, respectively, relative to the Sun. The origin of the large overabundances is unclear. We discuss the roles of neutron-capture nucleosynthesis in the-precursor star and radiation-driven diffusion. It is possible that diffusion is insignificant and thaI the observed metal abundances constrain the evolutionary history of the star. Its hydrogen deficiency may be the consequence of a late helium-shell nash or a binary white dwarf merger.

  18. Noble Liquid (Xenon or Krypton) Totally Active Calorimetry

    CERN Multimedia

    2002-01-01

    Main Goals\\\\ \\\\ Determine ionization and scintillation yields in liquid Xenon (LXe) or Krypton.\\\\ \\\\ Determine the electron lifetime and photon mean free path in LXe or LKr. \\\\ \\\\ Determine energy resolution of LXe or LKr via ionization or scintillation.\\\\ \\\\ Determine correlation of fluctuations between ionization and scintillation. Summary of Results \\\\ \\\\ -~measured the electron lifetime in LXe, ($\\tau$~$>$~400 $\\mu$s).\\\\ \\\\ -~measured the energy to create an ionization electron in LXe, W=9.8 eV.\\\\ \\\\ -~measured the energy to create a LXe scintillation photon, W$ _{s} $~=~14.2~eV. \\\\ \\\\ -~measured the anticorrelation of scintillation and ionization yields. \\\\ \\\\ -~measured the energy resolution in LXe via ionization, $ sigma _{E} / $E=0.07\\%/$\\sqrt$E(GeV). \\\\ \\\\ -~measured resolution in LXe via scintillation $ sigma _{E} / $E=0.24\\%/$\\sqrt$E(GeV)+0.26\\%. \\\\ \\\\ -~measured electron drift velocity in LXe:~neat (2.5 mm/$\\mu$s), doped (4.4~mm/$\\mu$s). \\\\ \\\\ -~measured the photon mean free path in LXe vs $ lambd...

  19. An homeopathic cure to pure Xenon large diffusion

    CERN Document Server

    Azevedo, C.D.R.; Freitas, E.D.C.; Gonzalez-Diaz, D.; Monrabal, F.; Monteiro, C.M.B.; dos Santos, J. M. F.; Veloso, J.F.C.A.; Gomez-Cadenas, J. J

    2016-02-03

    The NEXT neutrinoless double beta decay experiment will use a high- pressure gas electroluminescence-based TPC to search for the decay of Xe-136. One of the main advantages of this technology is the possibility to reconstruct the topology of events with energies close to Qbb. The rejection potential associated to the topology reconstruction is limited by our capacity to prop- erly reconstruct the original path of the electrons in the gas. This reconstruction is limited by different factors that include the geometry of the detector, the density of the sensors in the tracking plane and the separation among them, etc. Ultimately, the resolution is limited by the physics of electron diffusion in the gas. In this paper we present a series of molecular additives that can be used in Xenon gas at very low partial pressure to reduce both longitudinal and transverse diffusion. We will show the results of different Monte-Carlo simulations of electron transport in the gas mixtures from wich we have extracted the value of...

  20. Revised analysis of singly ionized xenon, Xe II

    International Nuclear Information System (INIS)

    Hansen, J.E.; Persson, W.

    1987-01-01

    We present a revised analysis of the spectrum of singly ionized xenon, Xe II. This spectrum has been reanalyzed on the basis of the wavelength material published by Drs J. C. Boyce and C. J. Humphreys. The latter has kindly placed the original wavelength list covering the wavelength range 10220-390 A at our disposal. We report 161 energy levels which have been identified on the basis of classifications of 950 lines. We report first f and g levels in Xe II. Also a number of g-factors have been determined for the first time and we give in total 75 g-factors. We have carried out least-squares fits to the even configurations and report the resulting parameter values and eigenvector compositions. A least-squares fit to the 5p 4 6p configuration is also reported. The levels have been named in jK and for many levels also in LS coupling. The former is the better coupling scheme for Xe II. We present an analysis of the 5s photoelectron satellite spectrum of Xe based on our calculated eigenvector compositions and calculations of transition probabilities for ground state transitions as well as lifetimes for the 6p levels. The latter are compared to recent experimental measurements. A list of wavelengths for observed laser transitions showing the present classifications and a discussion of the determination of the ionization potential of Xe II concludes the paper. (orig.)

  1. Xenon Recovery at Room Temperature using Metal-Organic Frameworks

    Energy Technology Data Exchange (ETDEWEB)

    Elsaidi, Sameh K. [Physical and Computational Science Directorate, Pacific Northwest National Laboratory, Richland WA 99352 USA; Chemistry Department, Faculty of Science, Alexandria University, P. O. Box 426 Ibrahimia Alexandria 21321 Egypt; Ongari, Daniele [Laboratory of Molecular Simulation, Institut des Sciences et Ingeénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), Rue de l' Industrie 17 1951 Sion Valais Switzerland; Xu, Wenqian [X-ray Science Division, Advanced Photon Source, Argonne National Laboratory, Argonne IL 60439 USA; Mohamed, Mona H. [Chemistry Department, Faculty of Science, Alexandria University, P. O. Box 426 Ibrahimia Alexandria 21321 Egypt; Haranczyk, Maciej [IMDEA Materials Institute, c/Eric Kandel 2 28906 Getafe, Madrid Spain; Thallapally, Praveen K. [Physical and Computational Science Directorate, Pacific Northwest National Laboratory, Richland WA 99352 USA

    2017-07-24

    Xenon is known to be a very efficient anesthetic gas but its cost prohibits the wider use in medical industry and other potential applications. It has been shown that Xe recovery and recycle from anesthetic gas mixture can significantly reduce its cost as anesthetic. The current technology uses series of adsorbent columns followed by low temperature distillation to recover Xe, which is expensive to use in medical facilities. Herein, we propose much efficient and simpler system to recover and recycle Xe from simulant exhale anesthetic gas mixture at room temperature using metal organic frameworks. Among the MOFs tested, PCN-12 exhibits unprecedented performance with high Xe capacity, Xe/O2, Xe/N2 and Xe/CO2 selectivity at room temperature. The in-situ synchrotron measurements suggest the Xe is occupied in the small pockets of PCN-12 compared to unsaturated metal centers (UMCs). Computational modeling of adsorption further supports our experimental observation of Xe binding sites in PCN-12.

  2. Production of fusion radionuclides: Molybdenum-99/ Iodine - 131 and Xenon-133; Produccion de los radionucleidos de fision: Molibdeno-99, Yodo-131 y Xenon-133

    Energy Technology Data Exchange (ETDEWEB)

    Barrachina, M; Carrillo, D

    1982-07-01

    This report presents a new radiochemical method for industrial production of the radionuclides: molybdenum-99, iodine-131 and xenon-133. The above mentioned method based on the alkaline metathesis reaction of irradiated uranium (IV) fluoride, presents the best characteristics for the proposed objective. The study deals with the analysis of that reaction and the separation and purification processes. (Author) 71 refs.

  3. Gas purity analytics, calibration studies, and background predictions towards the first results of XENON1T

    Energy Technology Data Exchange (ETDEWEB)

    Hasterok, Constanze

    2017-10-25

    The XENON1T experiment aims at the direct detection of the well motivated dark matter candidate of weakly interacting massive particles (WIMPs) scattering off xenon nuclei. The first science run of 34.2 live days has already achieved the most stringent upper limit on spin-independent WIMP-nucleon cross-sections above masses of 10 GeV with a minimum of 7.7.10{sup -47} cm{sup 2} at a mass of 35 GeV. Crucial for this unprecedented sensitivity are a high xenon gas purity and a good understanding of the background. In this work, a procedure is described that was developed to measure the purity of the experiment's xenon inventory of more than three tons during its initial transfer to the detector gas system. The technique of gas chromatography has been employed to analyze the noble gas for impurities with the focus on oxygen and krypton contaminations. Furthermore, studies on the calibration of the experiment's dominating background induced by natural gamma and beta radiation were performed. Hereby, the novel sources of radioactive isotopes that can be dissolved in the xenon were employed, namely {sup 220}Rn and tritium. The sources were analyzed in terms of a potential impact on the outcome of a dark matter search. As a result of the promising findings for {sup 220}Rn, the source was successfully deployed in the first science run of XENON1T. The first WIMP search of XENON1T is outlined in this thesis, in which a background component from interactions taking place in close proximity to the detector wall is identified, investigated and modeled. A background prediction was derived that was incorporated into the background model of the WIMP search which was found to be in good agreement with the observation.

  4. 16-Channel surface coil for 13C-hyperpolarized spectroscopic imaging of cardiac metabolism in pig heart

    DEFF Research Database (Denmark)

    Frijia, Francesca; Santarelli, Maria Filomena; Koellisch, Ulrich

    2016-01-01

    Magnetic resonance spectroscopy (MRS) of hyperpolarized 13C pyruvate and its metabolites in large animal models is a powerful tool for assessing cardiac metabolism in patho-physiological conditions. In 13C studies, a high signal-to-noise ratio (SNR) is crucial to overcome the intrinsic data quality...... both targets. In this study, a 16-channel receive surface coil was designed for 13C hyperpolarized studies of the pig heart with a clinical 3-T scanner. The coil performance was characterized by phantom experiments and compared with that of a birdcage coil used in transmit/receive mode. Segmental...... of the 16-channel coil is recommended for studies of septal and anterior LV walls....

  5. Facilitated Anion Transport Induces Hyperpolarization of the Cell Membrane That Triggers Differentiation and Cell Death in Cancer Stem Cells.

    Science.gov (United States)

    Soto-Cerrato, Vanessa; Manuel-Manresa, Pilar; Hernando, Elsa; Calabuig-Fariñas, Silvia; Martínez-Romero, Alicia; Fernández-Dueñas, Víctor; Sahlholm, Kristoffer; Knöpfel, Thomas; García-Valverde, María; Rodilla, Ananda M; Jantus-Lewintre, Eloisa; Farràs, Rosa; Ciruela, Francisco; Pérez-Tomás, Ricardo; Quesada, Roberto

    2015-12-23

    Facilitated anion transport potentially represents a powerful tool to modulate various cellular functions. However, research into the biological effects of small molecule anionophores is still at an early stage. Here we have used two potent anionophore molecules inspired in the structure of marine metabolites tambjamines to gain insight into the effect induced by these compounds at the cellular level. We show how active anionophores, capable of facilitating the transmembrane transport of chloride and bicarbonate in model phospholipid liposomes, induce acidification of the cytosol and hyperpolarization of plasma cell membranes. We demonstrate how this combined effect can be used against cancer stem cells (CSCs). Hyperpolarization of cell membrane induces cell differentiation and loss of stemness of CSCs leading to effective elimination of this cancer cell subpopulation.

  6. Hyperpolarized 13C-Urea MRI for the assessment of the urea gradient in the porcine kidney

    DEFF Research Database (Denmark)

    Søvsø Szocska Hansen, Esben; Stewart, Neil James; Wild, Jim Michael

    Renal anatomical and pathophysiological alterations are directly associated with the fluid and electrolyte balance in the kidney, which is regulated by the extracellular corticomedullary osmolality gradient. We introduce a novel magnetic resonance imaging (MRI) approach to monitor...... treatment resulted in an increased urea accumulation in the cortical space. This work demonstrates intra-renal functional assessment with hyperpolarized 13C-urea MRI in multi-papillary kidneys....

  7. Low-Cost, High-Throughput 3-D Pulmonary Imager Using Hyperpolarized Contrast Agents and Low-Field MRI

    Science.gov (United States)

    2017-10-01

    low- cost and high-throughput was a key element proposed for this project, which we believe will be of significant benefit to the patients suffering...Award Number: W81XWH-15-1-0272 TITLE: Low- Cost , High-Throughput 3-D Pulmonary Imager Using Hyperpolarized Contrast Agents and Low-Field MRI...STATEMENT: Approved for Public Release; Distribution Unlimited The views, opinions and/or findings contained in this report are those of the author(s

  8. Low Cost, High-Throughput 3-D Pulmonary Imager Using Hyperpolarized Contrast Agents and Low-Field MRI

    Science.gov (United States)

    2017-10-01

    greater gas polarizations and production amounts/ throughputs- benefiting in particular from the advent of com- pact, high-power, relatively low- cost ...Award Number: W81XWH-15-1-0271 TITLE: Low- Cost , High-Throughput 3-D Pulmonary Imager Using Hyperpolarized Contrast Agents and Low-Field MRI...DISTRIBUTION STATEMENT: Approved for Public Release; Distribution Unlimited The views, opinions and/or findings contained in this report are those of the

  9. Integrated B1+ Mapping for Hyperpolarized 13C MRI in a Clinical Setup using Multi-Channel Receive Arrays

    DEFF Research Database (Denmark)

    Hansen, Rie Beck; Shin, Peter J.; Gordon, Jeremy W.

    inhomogeneous transmit coils, and because kinetic modeling based on incorrect flip angles can lead to incorrect rate constant estimations. This study demonstrates the feasibility of integrated B1+ mapping for large volume thermal and hyperpolarized phantoms in a clinical setup using a clamshell transmit coil...... and a 16-channel receive array, and a 3D stack-of-spirals sequence. Phase-sensitive coil-combination was achieved using ESPIRiT....

  10. Quantitative cerebral blood flow calculation method using xenon CT. Introduction of a factor reflecting diffusing capacity of the lung for xenon

    International Nuclear Information System (INIS)

    Sase, Shigeru; Honda, Mitsuru; Noguchi, Yoshitaka

    2007-01-01

    In calculating cerebral blood flow (CBF) using the Fick principle, time-course information on arterial tracer concentration is indispensable and exerts considerable influence on the accuracy of CBF. In xenon-enhanced CT (Xe-CT), the time-course change rate for end-tidal xenon concentration (Ke), which can be measured, and that for arterial xenon concentration (Ka) have been assumed to be equal. However, it has been pointed out that there are large differences between Ke and Ka in many cases. We have introduced a single factor (γ) which correlates Ke with Ka in the equation Ka=γ x (1-e -Ke/γ ). This factor, γ, reflects the diffusing capacity of the lung for xenon; larger γ values correspond to larger diffusing capacities and Ka is equal to Ke when γ is infinity. Kety's equation contains two parameters: CBF and xenon solubility coefficient We added a third parameter, γ, to Kety's equation, and developed an efficient method to obtain the γ value for each Xe-CT study. Applying this method to ten normal subjects (35.4±16.3 years, mean±standard deviation (SD)), we obtained γ value of 1.01±0.17 and the average CBF value of 38.8±7.5 mL/100 g/min in basal ganglia. The wash-in period could be shortened to two minutes using this method. Xe-CT with this factor (γ) as a parameter enhances its clinical availability as well as the accuracy of CBF. (author)

  11. A continuous-flow, high-throughput, high-pressure parahydrogen converter for hyperpolarization in a clinical setting.

    Science.gov (United States)

    Hövener, Jan-Bernd; Bär, Sébastien; Leupold, Jochen; Jenne, Klaus; Leibfritz, Dieter; Hennig, Jürgen; Duckett, Simon B; von Elverfeldt, Dominik

    2013-02-01

    Pure parahydrogen (pH(2) ) is the prerequisite for optimal pH(2) -based hyperpolarization experiments, promising approaches to access the hidden orders of magnitude of MR signals. pH(2) production on-site in medical research centers is vital for the proliferation of these technologies in the life sciences. However, previously suggested designs do not meet our requirements for safety or production performance (flow rate, pressure or enrichment). In this article, we present the safety concept, design and installation of a pH(2) converter, operated in a clinical setting. The apparatus produces a continuous flow of four standard liters per minute of ≈98% enriched pH(2) at a pressure maximum of 50 bar. The entire production cycle, including cleaning and cooling to 25 K, takes less than 5 h, only ≈45 min of which are required for actual pH(2) conversion. A fast and simple quantification procedure is described. The lifetimes of pH(2) in a glass vial and aluminum storage cylinder are measured to be T(1C) (glass vial) =822 ± 29 min and T(1C) (Al cylinder) =129 ± 36 days, thus providing sufficiently long storage intervals and allowing the application of pH(2) on demand. A dependence of line width on pH(2) enrichment is observed. As examples, (1) H hyperpolarization of pyridine and (13) C hyperpolarization of hydroxyethylpropionate are presented. Copyright © 2012 John Wiley & Sons, Ltd.

  12. Diet-induced obesity impairs endothelium-derived hyperpolarization via altered potassium channel signaling mechanisms.

    Directory of Open Access Journals (Sweden)

    Rebecca E Haddock

    Full Text Available BACKGROUND: The vascular endothelium plays a critical role in the control of blood flow. Altered endothelium-mediated vasodilator and vasoconstrictor mechanisms underlie key aspects of cardiovascular disease, including those in obesity. Whilst the mechanism of nitric oxide (NO-mediated vasodilation has been extensively studied in obesity, little is known about the impact of obesity on vasodilation to the endothelium-derived hyperpolarization (EDH mechanism; which predominates in smaller resistance vessels and is characterized in this study. METHODOLOGY/PRINCIPAL FINDINGS: Membrane potential, vessel diameter and luminal pressure were recorded in 4(th order mesenteric arteries with pressure-induced myogenic tone, in control and diet-induced obese rats. Obesity, reflecting that of human dietary etiology, was induced with a cafeteria-style diet (∼30 kJ, fat over 16-20 weeks. Age and sexed matched controls received standard chow (∼12 kJ, fat. Channel protein distribution, expression and vessel morphology were determined using immunohistochemistry, Western blotting and ultrastructural techniques. In control and obese rat vessels, acetylcholine-mediated EDH was abolished by small and intermediate conductance calcium-activated potassium channel (SK(Ca/IK(Ca inhibition; with such activity being impaired in obesity. SK(Ca-IK(Ca activation with cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl-6-methyl-pyrimidin-4-yl]-amine (CyPPA and 1-ethyl-2-benzimidazolinone (1-EBIO, respectively, hyperpolarized and relaxed vessels from control and obese rats. IK(Ca-mediated EDH contribution was increased in obesity, and associated with altered IK(Ca distribution and elevated expression. In contrast, the SK(Ca-dependent-EDH component was reduced in obesity. Inward-rectifying potassium channel (K(ir and Na(+/K(+-ATPase inhibition by barium/ouabain, respectively, attenuated and abolished EDH in arteries from control and obese rats, respectively; reflecting differential K

  13. Modeling the Removal of Xenon from Lithium Hydrate with Aspen HYSYS

    Science.gov (United States)

    Efthimion, Phillip; Gentile, Charles

    2011-10-01

    The Laser Inertial Fusion Engine (LIFE) project mission is to provide a long-term, carbon-free source of sustainable energy, in the form of electricity. A conceptual xenon removal system has been modeled with the aid of Aspen HYSYS, a chemical process simulator. Aspen HYSYS provides excellent capability to model chemical flow processes, which generates outputs which includes specific variables such as temperature, pressure, and molar flow. The system is designed to strip out hydrogen isotopes deuterium and tritium. The base design bubbles plasma exhaust laden with x filled with liquid helium. The system separates the xenon from the hydrogen, deuterium, and tritium with a lithium hydrate and a lithium bubbler. After the removal of the hydrogen and its isotopes, the xenon is then purified by way of the process of cryogenic distillation. The pure hydrogen, deuterium, and tritium are then sent to the isotope separation system (ISS). The removal of xenon is an integral part of the laser inertial fusion engine and Aspen HYSYS is an excellent tool to calculate how to create pure xenon.

  14. Internal plasma potential measurements of a Hall thruster using xenon and krypton propellant

    International Nuclear Information System (INIS)

    Linnell, Jesse A.; Gallimore, Alec D.

    2006-01-01

    For krypton to become a realistic option for Hall thruster operation, it is necessary to understand the performance gap between xenon and krypton and what can be done to reduce it. A floating emissive probe is used with the Plasmadynamics and Electric Propulsion Laboratory's High-speed Axial Reciprocating Probe system to map the internal plasma potential structure of the NASA-173Mv1 Hall thruster [R. R. Hofer, R. S. Jankovsky, and A. D. Gallimore, J. Propulsion Power 22, 721 (2006); and ibid.22, 732 (2006)] using xenon and krypton propellant. Measurements are taken for both propellants at discharge voltages of 500 and 600 V. Electron temperatures and electric fields are also reported. The acceleration zone and equipotential lines are found to be strongly linked to the magnetic-field lines. The electrostatic plasma lens of the NASA-173Mv1 Hall thruster strongly focuses the xenon ions toward the center of the discharge channel, whereas the krypton ions are defocused. Krypton is also found to have a longer acceleration zone than the xenon cases. These results explain the large beam divergence observed with krypton operation. Krypton and xenon have similar maximum electron temperatures and similar lengths of the high electron temperature zone, although the high electron temperature zone is located farther downstream in the krypton case

  15. Development of a liquid xenon Compton telescope dedicated to functional medical imaging

    International Nuclear Information System (INIS)

    Grignon, C.

    2007-12-01

    Functional imaging is a technique used to locate in three dimensions the position of a radiotracer previously injected in a patient. The two main modalities used for a clinical application to detect tumors, the SPECT and the PET, use solid scintillators as a detection medium. The objective of this thesis was to investigate the possibility of using liquid xenon in order to benefit from the intrinsic properties of this medium in functional imaging. The feasibility study of such a device has been performed by taking into account the technical difficulties specific to the liquid xenon. First of all, simulations of a liquid xenon PET has been performed using Monte-Carlo methods. The results obtained with a large liquid xenon volume are promising : we can expect a reduction of the injected activity of radiotracer, an improvement of the spatial resolution of the image and a parallax free camera. The second part of the thesis was focused on the development of a new concept of medical imaging, the three gamma imaging, based on the use of a new emitter: the 44 scandium. Associated to a classical PET camera, the Compton telescope is used to infer the incoming direction of the third gamma ray by triangulation. Therefore, it is possible to reconstruct the position of each emitter in three dimensions. This work convinced the scientific community to support the construction and characterization of a liquid xenon Compton telescope. The first camera dedicated to small animal imaging should then be operational in 2009. (author)

  16. The optimization of nuclear power plants operation modes in emergency situations

    Science.gov (United States)

    Zagrebayev, A. M.; Trifonenkov, A. V.; Ramazanov, R. N.

    2018-01-01

    An emergency situations resulting in the necessity for temporary reactor trip may occur at the nuclear power plant while normal operating mode. The paper deals with some of the operation c aspects of nuclear power plant operation in emergency situations and during threatened period. The xenon poisoning causes limitations on the variety of statements of the problem of calculating characteristics of a set of optimal reactor power off controls. The article show a possibility and feasibility of new sets of optimization tasks for the operation of nuclear power plants under conditions of xenon poisoning in emergency circumstances.

  17. 气相色谱氩、氪、氙、氡分离度初步研究%Resolutions on Mixture of Argon, Krypton, Xenon and Radon by Gas Chromatography

    Institute of Scientific and Technical Information of China (English)

    刘蜀疆; 陈占营; 常印忠; 王世联; 李奇; 石建芳; 樊元庆; 赵允刚

    2012-01-01

    核爆炸产生多种稀有气体核素,这些核素可作为核泄露监测对象.气相色谱是组分分离的重要手段,在核爆炸监测取样中有重要应用.本文以5A分子筛作为固定相,高纯氮作为流动相,测量了氩、氪、氙、氡在气相色谱中的分离效果.结果表明,在相同色谱条件下,氩、氪分离度小于氪、氙分离度;在柱流量35.6 mL/min、柱温353 K条件下,气相色谱氩、氪,氪、氙,氙、氡分离度均大于2.25.%Radio-isotopes of noble gas, which are produced during nuclear explosion, can escape into atmosphere easily. These isotopes can be measured as good indicators for nuclear explosion. Noble gas monitoring, including sampling, measurement and analysis, became more and more essential. Gas chromatography is an important technology on noble gas separation during gas sampling. In this paper, while 5A molecular sieve was utilized as column stationary state and high-purity nitrogen as column fluid state, resolutions of argon, krypton, xenon and radon were widely investigated under different chromatograph conditions. As a result, the resolution of krypton and argon is less than the resolution of xenon and krypton; when column flow rate is 35. 6 mL/min and oven temperature is 353 K, all of the resolutions of radon and xenon, xenon and krypton, krypton and argon are more than 2. 25.

  18. μ opioid receptor activation hyperpolarizes respiratory-controlling Kölliker-Fuse neurons and suppresses post-inspiratory drive.

    Science.gov (United States)

    Levitt, Erica S; Abdala, Ana P; Paton, Julian F R; Bissonnette, John M; Williams, John T

    2015-10-01

    In addition to reductions in respiratory rate, opioids also cause aspiration and difficulty swallowing, indicating impairment of the upper airways. The Kölliker-Fuse (KF) maintains upper airway patency and a normal respiratory pattern. In this study, activation of μ opioid receptors in the KF reduced respiratory frequency and tidal volume in anaesthetized rats. Nerve recordings in an in situ preparation showed that activation of μ opioid receptors in the KF eliminated the post-inspiration phase of the respiratory cycle. In brain slices, μ opioid agonists hyperpolarized a distinct population (61%) of KF neurons by activation of an inwardly rectifying potassium conductance. These results suggest that KF neurons that are hyperpolarized by opioids could contribute to opioid-induced respiratory disturbances, particularly the impairment of upper airways. Opioid-induced respiratory effects include aspiration and difficulty swallowing, suggesting impairment of the upper airways. The pontine Kölliker-Fuse nucleus (KF) controls upper airway patency and regulates respiration, in particular the inspiratory/expiratory phase transition. Given the importance of the KF in coordinating respiratory pattern, the mechanisms of μ opioid receptor activation in this nucleus were investigated at the systems and cellular level. In anaesthetized, vagi-intact rats, injection of opioid agonists DAMGO or [Met(5) ]enkephalin (ME) into the KF reduced respiratory frequency and amplitude. The μ opioid agonist DAMGO applied directly into the KF of the in situ arterially perfused working heart-brainstem preparation of rat resulted in robust apneusis (lengthened low amplitude inspiration due to loss of post-inspiratory drive) that was rapidly reversed by the opioid antagonist naloxone. In brain slice preparations, activation of μ opioid receptors on KF neurons hyperpolarized a distinct population (61%) of neurons. As expected, the opioid-induced hyperpolarization reduced the excitability of

  19. A semi-analytical treatment of xenon oscillations

    International Nuclear Information System (INIS)

    Zarei, M.; Minuchehr, A.; Ghaderi, R.

    2017-01-01

    Highlights: • A two-group two region kinetic core model is developed employing the eigenvalues separation index. • Poison dynamics are investigated within an adiabatic approach. • The overall nonlinear reactor model is recast into a linear time varying framework incorporating the matrix exponential numerical scheme. • The largest Lyapunov exponent is employed to analytically verify model stability. - Abstract: A novel approach is developed to investigate xenon oscillations within a two-group two-region coupled core reactor model incorporating thermal feedback and poison effects. Group-wise neutronic coupling coefficients between the core regions are calculated applying the associated fundamental and first mode eigenvalue separation values. The resultant nonlinear state space representation of the core behavior is quite suitable for evaluation of reactivity induced power transients such as load following operation. The model however comprises a multi-physics coupling of sub-systems with extremely distant relaxation times whose stiffness treatment inquire costly multistep implicit numerical methods. An adiabatic treatment of the sluggish poison dynamics is therefore proposed as a way out. The approach helps further investigate the nonlinear system within a linear time varying (LTV) framework whereby a semi-analytical framework is established. This scheme incorporates a matrix exponential analytical solution of the perturbed system as a quite efficient tool to study load following operation and control purposes. Poison dynamics are updated within larger intervals which exclude the need for specific numerical schemes of stiff systems. Simulation results of the axial offset conducted on a VVER-1000 reactor at the beginning (BOC) and the end of cycle (EOC) display quite acceptable results compared with available benchmarks. The LTV reactor model is further investigated within a stability analysis of the associated time varying systems at these two stages

  20. Effects of pulmonary inhalation on hyperpolarized krypton-83 magnetic resonance T1 relaxation.

    Science.gov (United States)

    Stupic, K F; Elkins, N D; Pavlovskaya, G E; Repine, J E; Meersmann, T

    2011-07-07

    The (83)Kr magnetic resonance (MR) relaxation time T(1) of krypton gas in contact with model surfaces was previously found to be highly sensitive to surface composition, surface-to-volume ratio, and surface temperature. The work presented here explored aspects of pulmonary (83)Kr T(1) relaxation measurements in excised lungs from healthy rats using hyperpolarized (hp) (83)Kr with approximately 4.4% spin polarization. MR spectroscopy without spatial resolution was applied to the ex vivo lungs that actively inhale hp (83)Kr through a custom designed ventilation system. Various inhalation schemes were devised to study the influence of anatomical dead space upon the measured (83)Kr T(1) relaxation times. The longitudinal (83)Kr relaxation times in the distal airways and the respiratory zones were independent of the lung inhalation volume, with T(1) = 1.3 s and T(1) = 1.0 s, depending only on the applied inhalation scheme. The obtained data were highly reproducible between different specimens. Further, the (83)Kr T(1) relaxation times in excised lungs were unaffected by the presence of up to 40% oxygen in the hp gas mixture. The results support the possible importance of (83)Kr as a biomarker for evaluating lung function.

  1. Measurement of lung airways in three dimensions using hyperpolarized helium-3 MRI

    International Nuclear Information System (INIS)

    Peterson, Eric T; Fain, Sean B; Dai Jionghan; Holmes, James H

    2011-01-01

    Large airway measurement is clinically important in cases of airway disease and trauma. The gold standard is computed tomography (CT), which allows for airway measurement. However, the ionizing radiation dose associated with CT is a major limitation in longitudinal studies and trauma. To avoid ionizing radiation from CT, we present a method for measuring the large airway diameter in humans using hyperpolarized helium-3 (HPHe) MRI in conjunction with a dynamic 3D radial acquisition. An algorithm is introduced which utilizes the significant airway contrast for semi-automated segmentation and skeletonization which is used to derive the airway lumen diameter. The HPHe MRI method was validated with quantitative CT in an excised and desiccated porcine lung (linear regression R 2 = 0.974 and slope = 0.966 over 32 airway segments). The airway lumen diameters were then compared in 24 human subjects (22 asthmatics and 2 normals; linear regression R 2 value of 0.799 and slope = 0.768 over 309 airway segments). The feasibility for airway path analysis to areas of ventilation defect is also demonstrated.

  2. Two-group Analysis of Xenon Stability in Slab Geometry by Modal Expansion

    International Nuclear Information System (INIS)

    Norinder, O.

    1963-05-01

    Xenon spatial stability is analyzed with the flux represented by two neutron energy groups. General formulas are given for expansions in a system of modes. Detailed formulas are recorded for a slab described by sinusoidal modes. A short description is given of a Mercury Autocode program for numerical calculations in slab geometry. The essential input parameters and results are noted for 80 computed cases. The main body of the calculations were intended to clarify the xenon stability properties of the Marviken reactor, which was found to have a sufficient margin against unstable xenon oscillations. The neutron flux detection and the control rod insertion in the slab were found to have a large influence on the stability in spite of the nonexistence of space-selective control in the systems investigated. Very good agreement was found between stability limits calculated according to Randall and St. John and stability limits calculated by the program

  3. Bonding xenon and krypton on the surface of uranium dioxide single crystal

    Directory of Open Access Journals (Sweden)

    Dąbrowski Ludwik

    2014-08-01

    Full Text Available We present density functional theory (DFT calculation results of krypton and xenon atoms interaction on the surface of uranium dioxide single crystal. A pseudo-potential approach in the generalised gradient approximation (GGA was applied using the ABINIT program package. To compute the unit cell parameters, the 25 atom super-cell was chosen. It has been revealed that close to the surface of a potential well is formed for xenon and krypton atom due to its interaction with the atoms of oxygen and uranium. Depth and shape of the well is the subject of ab initio calculations in adiabatic approximation. The calculations were performed both for the case of oxygenic and metallic surfaces. It has been shown that the potential well for the oxygenic surface is deeper than for the metallic surface. The thermal stability of immobilising the atoms of krypton and xenon in the potential wells were evaluated. The results are shown in graphs.

  4. Iodide and xenon enhancement of computed tomography (CT) in multiple sclerosis (MS)

    International Nuclear Information System (INIS)

    Radue, E.W.; Kendall, B.E.

    1978-01-01

    The characteristic findings on computed tomography (CT) in multiple sclerosis (MS) are discussed. In a series of 49 cases plain CT was normal in 21 (43%), cerebral atrophy alone was present in 17 (35%) and plaques were visible in 11 (23%). These were most often adjacent to the lateral ventricles (14 plaques) and in the parietal white matter (10 plaques). CT was performed after the intravenous administration of iodide in 16 of these cases. Two patients with low attenuation plaques were scanned with xenon enhancement; the plaques absorbed less xenon than the corresponding contralateral brain substance and additional, previously isodense plaques were revealed. In one case the white matter absorbed much less xenon than normal and its uptake relative to grey matter was reduced. (orig.) [de

  5. Performance of a cryogenic system prototype for the XENON1T detector

    International Nuclear Information System (INIS)

    Aprile, E; Budnik, R; Choi, B; Contreras, H A; Giboni, K L; Goetzke, L W; Lang, R F; Lim, K E; Melgarejo, A J; Plante, G; Rizzo, A; Shagin, P

    2012-01-01

    We have developed an efficient cryogenic system with heat exchange and associated gas purification system as a prototype for the XENON1T experiment. The XENON1T detector will use about 3 tons of liquid xenon (LXe) at a temperature of 175K as target and detection medium for a dark matter search. In this paper we report results on the cryogenic system performance focusing on the dynamics of the gas circulation-purification through a heated getter, at flow rates above 50 Standard Liter per Minute (SLPM). A maximum flow of 114 SLPM has been achieved, and using two heat exchangers in series, a heat exchange efficiency better than 96% has been measured.

  6. Spectra of copperlike and zinclike xenon: Xe XXV and Xe XXVI

    International Nuclear Information System (INIS)

    Kaufman, V.; Sugar, J.; Rowan, W.L.

    1988-01-01

    The spectra of highly ionized xenon were generated in a tokamak plasma and photographed in the region 60--350 A with a 2.2-m grazing-incidence spectrograph. The 4s 2 --4s4p transitions of Zn-like xenon (Xe XXV) and all the 4l--4(l+1) transitions of Cu-like xenon (Xe XXVI) were measured with estimated uncertainties of +- 0.005 A. These measurements have been combined with previous wavelength measurements of Xe XXVI to determine energy levels. A value for the ionization energy of Xe 25+ of 6 912 400 +- 3000 cm -1 (857.0 +- 0.4 eV) was derived

  7. Status of the 2D Bayesian analysis of XENON100 data

    Energy Technology Data Exchange (ETDEWEB)

    Schindler, Stefan [JGU, Staudingerweg 7, 55128 Mainz (Germany)

    2015-07-01

    The XENON100 experiment is located in the underground laboratory at LNGS in Italy. Since Dark Matter particles will only interact very rarely with normal matter, an environment with ultra low background, which is shielded from cosmic radiation is needed. The standard analysis of XENON100 data has made use of the profile likelihood method (a most frequent approach) and still provides one of the most sensitive exclusion limits to WIMP Dark Matter. Here we present work towards a Bayesian approach to the analysis of XENON100 data, where we attempt to include the measured primary (S1) and secondary (S2) scintillation signals in a more complete way. The background and signal models in the S1-S2 space have to be defined and a corresponding likelihood function, describing these models, has to be constructed.

  8. Measurement of vascular flow in the brain with the xenon/CT method

    International Nuclear Information System (INIS)

    Wist, A.O.; Cothran, A.; Fatouros, P.P.; Kishore, P.R.S.

    1988-01-01

    The authors are proposing a modification of the xenon/CT method that allows measurement of the flow in the different brain vessels. Based on an improved stable xenon/CT method, they developed several additional algorithms to differentiate the vessel flow from tissue flow and from artifacts and noise, which are based on the height, steepness, and other parameters of the detected flow values. The vessel flow maps, together with the tissue flow maps and new composite flow maps of recent patients, demonstrate that the stable xenon/CT technique can be extended to quantify vascular flow in the brain. The diagnostic capability of this method can be further improved by removing the vessel flow from the flow maps

  9. Study of the short-lived fission products. Separation of iodine and xenon fission radionuclides

    International Nuclear Information System (INIS)

    Barrachina, M.; Villar, M. A.

    1965-01-01

    The separation by distillation in a sulfuric acid or phosphoric acid-hydrogen peroxide medium of the iodine isotopes (8 day iodine-131, 2,3 hour iodine-132 21 hour iodine-133, 53 minute iodine-134 and 6,7 hour iodine-135) present in a uranium sample after different irradiation and cooling times is here described. It is also reported the use of active charcoal columns for the retention of xenon isotopes (5,27 days xenon-133 and 9,2 hours xenon-135) either released during the dissolution of the uranium irradiated samples or generated along the fission isobaric chains in the solutions of distillated iodine. In both cases the radiochemical purity of the separated products is established by gamma spectrometry. (Author) 15 refs

  10. Quantitative analysis technique for Xenon in PWR spent fuel by using WDS

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, H. M.; Kim, D. S.; Seo, H. S.; Ju, J. S.; Jang, J. N.; Yang, Y. S.; Park, S. D. [KAERI, Daejeon (Korea, Republic of)

    2012-01-15

    This study includes three processes. First, a peak centering of the X-ray line was performed after a diffraction for Xenon La1 line was installed. Xe La1 peak was identified by a PWR spent fuel sample. Second, standard intensities of Xe was obtained by interpolation of the La1 intensities from a series of elements on each side of xenon. And then Xe intensities across the radial direction of a PWR spent fuel sample were measured by WDS-SEM. Third, the electron and X-ray depth distributions for a quantitative electron probe micro analysis were simulated by the CASINO Monte Carlo program to do matrix correction of a PWR spent fuel sample. Finally, the method and the procedure for local quantitative analysis of Xenon was developed in this study.

  11. Search for 136Xe neutrinoless double beta decay with the Enriched Xenon Observatory (EXO)

    International Nuclear Information System (INIS)

    Giroux, G.

    2014-01-01

    The EXO collaboration is searching for the neutrinoless double beta decay of 136 Xe. Such observation would determine an absolute mass scale for the neutrinos, establish their Majorana nature, and uncover physics beyond the Standard Model. The EXO-200 detector is a single phase liquid xenon ultra low background TPC (Time Projection Chamber), with an active mass of 110 kg of 80.6% enriched xenon in the isotope 136. The detector is currently operating at the WIPP site and has been collecting data with enriched xenon since May 2011. The data collected give a lower limit for the neutrinoless double beta decay half-life of 136 Xe: T > 1.6*10 25 years at 90% C.L. The same data give a lower limit for the 2 neutrinos double beta decay of 136 Xe: T > 2.23*10 21 years that agrees with experimental values found in the literature

  12. Probe of Multielectron Dynamics in Xenon by Caustics in High-Order Harmonic Generation

    Science.gov (United States)

    Faccialà, D.; Pabst, S.; Bruner, B. D.; Ciriolo, A. G.; De Silvestri, S.; Devetta, M.; Negro, M.; Soifer, H.; Stagira, S.; Dudovich, N.; Vozzi, C.

    2016-08-01

    We investigated the giant resonance in xenon by high-order harmonic generation spectroscopy driven by a two-color field. The addition of a nonperturbative second harmonic component parallel to the driving field breaks the symmetry between neighboring subcycles resulting in the appearance of spectral caustics at two distinct cutoff energies. By controlling the phase delay between the two color components it is possible to tailor the harmonic emission in order to amplify and isolate the spectral feature of interest. In this Letter we demonstrate how this control scheme can be used to investigate the role of electron correlations that give birth to the giant resonance in xenon. The collective excitations of the giant dipole resonance in xenon combined with the spectral manipulation associated with the two-color driving field allow us to see features that are normally not accessible and to obtain a good agreement between the experimental results and the theoretical predictions.

  13. Two-group Analysis of Xenon Stability in Slab Geometry by Modal Expansion

    Energy Technology Data Exchange (ETDEWEB)

    Norinder, O

    1963-05-15

    Xenon spatial stability is analyzed with the flux represented by two neutron energy groups. General formulas are given for expansions in a system of modes. Detailed formulas are recorded for a slab described by sinusoidal modes. A short description is given of a Mercury Autocode program for numerical calculations in slab geometry. The essential input parameters and results are noted for 80 computed cases. The main body of the calculations were intended to clarify the xenon stability properties of the Marviken reactor, which was found to have a sufficient margin against unstable xenon oscillations. The neutron flux detection and the control rod insertion in the slab were found to have a large influence on the stability in spite of the nonexistence of space-selective control in the systems investigated. Very good agreement was found between stability limits calculated according to Randall and St. John and stability limits calculated by the program.

  14. Quantitative analysis technique for Xenon in PWR spent fuel by using WDS

    International Nuclear Information System (INIS)

    Kwon, H. M.; Kim, D. S.; Seo, H. S.; Ju, J. S.; Jang, J. N.; Yang, Y. S.; Park, S. D.

    2012-01-01

    This study includes three processes. First, a peak centering of the X-ray line was performed after a diffraction for Xenon La1 line was installed. Xe La1 peak was identified by a PWR spent fuel sample. Second, standard intensities of Xe was obtained by interpolation of the La1 intensities from a series of elements on each side of xenon. And then Xe intensities across the radial direction of a PWR spent fuel sample were measured by WDS-SEM. Third, the electron and X-ray depth distributions for a quantitative electron probe micro analysis were simulated by the CASINO Monte Carlo program to do matrix correction of a PWR spent fuel sample. Finally, the method and the procedure for local quantitative analysis of Xenon was developed in this study

  15. Xenon ventilation CT using dual-source and dual-energy technique in children with bronchiolitis obliterans: correlation of xenon and CT density values with pulmonary function test results

    International Nuclear Information System (INIS)

    Goo, Hyun Woo; Yang, Dong Hyun; Seo, Joon Beom; Chae, Eun Jin; Lee, Jeongjin; Hong, Soo-Jong; Yu, Jinho; Kim, Byoung-Ju; Krauss, Bernhard

    2010-01-01

    Xenon ventilation CT using dual-source and dual-energy technique is a recently introduced, promising functional lung imaging method. To expand its clinical applications evidence of additional diagnostic value of xenon ventilation CT over conventional chest CT is required. To evaluate the usefulness of xenon ventilation CT using dual-source and dual-energy technique in children with bronchiolitis obliterans (BO). Seventeen children (age 7-18 years; 11 boys) with BO underwent xenon ventilation CT using dual-source and dual-energy technique. Xenon and CT density values were measured in normal and hyperlucent lung regions on CT and were compared between the two regions. Volumes of hyperlucent regions and ventilation defects were calculated with thresholds determined by visual and histogram-based analysis. Indexed volumes of hyperlucent lung regions and ventilation defects were correlated with pulmonary function test results. Effective doses of xenon CT were calculated. Xenon (14.6 ± 6.4 HU vs 26.1 ± 6.5 HU; P 25-75 , (γ = -0.68-0.88, P ≤ 0.002). Volume percentages of xenon ventilation defects (35.0 ± 16.4%)] were not significantly different from those of hyperlucent lung regions (38.2 ± 18.6%). However, mismatches between the volume percentages were variable up to 21.4-33.3%. Mean effective dose of xenon CT was 1.9 ± 0.5 mSv. In addition to high-resolution anatomic information, xenon ventilation CT using dual-source and dual-energy technique demonstrates impaired regional ventilation and its heterogeneity accurately in children with BO without additional radiation exposure. (orig.)

  16. Xenon-induced axial power oscillations in the 400 MW PBMR

    International Nuclear Information System (INIS)

    Strydom, Gerhard

    2008-01-01

    The redistribution of the spatial xenon concentration in the 400 MW Pebble Bed Modular Reactor (PBMR) core has a non-linear, time-dependent feedback effect on the spatial power density during several types of operational transient events. Due to the inherent weak coupling that exists between the iodine and xenon formation and destruction rates, as well as the complicating effect of spatial variance in the thermal flux field, reactor cores have been analyzed for a number of decades for the occurrence and severity of xenon-induced axial power oscillations. Of specific importance is the degree of oscillation damping exhibited by the core during transients, which involves axial variations in the local power density. In this paper the TINTE reactor dynamics code is used to assess the stability of the current 400 MW PBMR core design with regard to axial xenon oscillations. The focus is mainly on the determination of the inherent xenon and power oscillation damping properties by utilizing a set of hypothetical control rod insertion transients at various power levels. The oscillation damping properties of two 100%-50%-100% load-follow transients, one of which includes the de-stabilizing axial effects of moving control rods, are also discussed in some detail. The study shows that, although first axial mode oscillations do occur in the 400 MW PBMR core, the inherent damping of these oscillations is high, and that none of the investigated load-follow transients resulted in diverging oscillations. It is also shown that the PBMR core exhibits no radial oscillation components for these xenon-induced axial power oscillations

  17. Charged particle identification with the liquid Xenon calorimeter of the CMD-3 detector

    International Nuclear Information System (INIS)

    Ivanov, V.L.; Fedotovich, G.V.; Anisenkov, A.V.; Grebenuk, A.A.; Mikhailov, K.Yu.; Kozyrev, A.A.; Shebalin, V.E.; Ruban, A.A.; Bashtovoy, N.S.

    2017-01-01

    This paper describes a procedure of particle identification with the liquid Xenon calorimeter of the CMD-3 detector currently being developed. The procedure uses the boosted decision tree classification method with specific energy losses of charged particles in the liquid Xenon calorimeter as input variables. The efficiency of the procedure is illustrated by an example of the measurement of the cross section of the process e + e − → K + K − in the center-of-mass energy range from 1.8 to 2.0 GeV.

  18. Near-infrared scintillation of xenon by 63Ni beta decay

    Science.gov (United States)

    Yoshimizu, Norimasa; Lal, Amit; Pollock, Clifford R.

    2006-07-01

    The near-infrared scintillation of xenon gas by the β decay of 37MBq of Ni63 was studied, in the interest of its use in integrated devices for applications such as optical beacons and wavelength calibration. The emission was imaged and analyzed using Spencer's theory of electron penetration using xenon scattering cross sections derived from Thomas-Fermi theory. The total emission was approximately 2×105photons/s at 20kPa and 1×105photons/s at 100kPa. Spectral data show three dominant peaks at 823, 828, and 882nm as well as the formation of metastable states.

  19. Xenon Defects in Uranium Dioxide From First Principles and Interatomic Potentials

    Science.gov (United States)

    Thompson, Alexander

    In this thesis, we examine the defect energetics and migration energies of xenon atoms in uranium dioxide (UO2) from first principles and interatomic potentials. We also parameterize new, accurate interatomic potentials for xenon and uranium dioxide. To achieve accurate energetics and provide a foundation for subsequent calculations, we address difficulties in finding consistent energetics within Hubbard U corrected density functional theory (DFT+U). We propose a method of slowly ramping the U parameter in order to guide the calculation into low energy orbital occupations. We find that this method is successful for a variety of materials. We then examine the defect energetics of several noble gas atoms in UO2 for several different defect sites. We show that the energy to incorporate large noble gas atoms into interstitial sites is so large that it is energetically favorable for a Schottky defect cluster to be created to relieve the strain. We find that, thermodynamically, xenon will rarely ever be in the interstitial site of UO2. To study larger defects associated with the migration of xenon in UO 2, we turn to interatomic potentials. We benchmark several previously published potentials against DFT+U defect energetics and migration barriers. Using a combination of molecular dynamics and nudged elastic band calculations, we find a new, low energy migration pathway for xenon in UO2. We create a new potential for xenon that yields accurate defect energetics. We fit this new potential with a method we call Iterative Potential Refinement that parameterizes potentials to first principles data via a genetic algorithm. The potential finds accurate energetics for defects with relatively low amounts of strain (xenon in defect clusters). It is important to find accurate energetics for these sorts of low-strain defects because they essentially represent small xenon bubbles. Finally, we parameterize a new UO2 potential that simultaneously yields accurate vibrational properties

  20. Determination of hyperacute kidney rejection in different xenogeneic system by 133xenon washout technique

    International Nuclear Information System (INIS)

    Welter, H.; Schmidt, K.R.; Pfeifer, K.J.; Hammer, C.; Chaussy, C.

    1980-01-01

    1. 133 Xenon washout technique is suitable for studying all stages of xenogeneic kidney rejection. 2. Follow-up studies allow differentiation between kidney rejection and kidneys in shock. 3. Changes of intrarenal blood flow distribution correlate with the histologic changes caused by rejection. 4. Total blood flow measurements employing 133 xenon washout yield 10-20% lower values compared with venous outflow measurements. 5. Graft rejection in the xenogeneic cat-dog system can be significantly delayed by ALG pretreatment. 6. The beneficial effect of blood transfusion described in different clinical and experimental studies could not be found after pretreatment of dogs with fox red blood cells. (orig.)

  1. Analysis method for beta-gamma coincidence spectra from radio-xenon isotopes

    International Nuclear Information System (INIS)

    Yang Wenjing; Yin Jingpeng; Huang Xiongliang; Cheng Zhiwei; Shen Maoquan; Zhang Yang

    2012-01-01

    Radio-xenon isotopes monitoring is one important method for the verification of CTBT, what includes the measurement methods of HPGe γ spectrometer and β-γ coincidence. The article describes the analytic flowchart and method of three-dimensional beta-gamma coincidence spectra from β-γ systems, and analyses in detail the principles and methods of the regions of interest of coincidence spectra and subtracting the interference, finally gives the formula of radioactivity of Xenon isotopes and minimum detectable concentrations. Studying on the principles of three-dimensional beta-gamma coincidence spectra, which can supply the foundation for designing the software of β-γ coincidence systems. (authors)

  2. Novel xenon calibration scheme for two-photon absorption laser induced fluorescence of hydrogen

    Energy Technology Data Exchange (ETDEWEB)

    Elliott, Drew; Scime, Earl; Short, Zachary, E-mail: zdshort@mix.wvu.edu [Department of Physics and Astronomy, West Virginia University, Morgantown, West Virginia 26056 (United States)

    2016-11-15

    Two photon absorption laser induced fluorescence (TALIF) measurements of neutral hydrogen and its isotopes are typically calibrated by performing TALIF measurements on krypton with the same diagnostic system and using the known ratio of the absorption cross sections [K. Niemi et al., J. Phys. D 34, 2330 (2001)]. Here we present the measurements of a new calibration method based on a ground state xenon scheme for which the fluorescent emission wavelength is nearly identical to that of hydrogen, thereby eliminating chromatic effects in the collection optics and simplifying detector calibration. We determine that the ratio of the TALIF cross sections of xenon and hydrogen is 0.024 ± 0.001.

  3. 900-L liquid xenon cryogenic system operation for the MEG experiment

    CERN Document Server

    Haruyama, T; Mihara, S; Hisamatsu, Y; Iawamoto, W; Mori, T; Nishiguchi, H; Otani, W; Sawada, R; Uchiyama, Y; Nishitani, T

    2009-01-01

    A cryogenic system for the MEG (muon rare decay) experiment has started operation at the Paul Sherrer Institute in Zurich. The main part of the MEG detector is the 900-L liquid xenon calorimeter for gamma ray detection, equipped with 850 photo multipliers directly immersed in liquid xenon. A 200 W pulse tube cryocooler enabled LN2-free operation of this calorimeter. A liquid purification system; using a liquid pump and a zero boil-off 1000-L cryogenic buffer dewar is also included in the system. The first entire engineering run was carried out in November-December 2007 and satisfactory cryogenic performances were confirmed.

  4. First 0ν half-life limit from the Gotthard xenon time projection chamber

    International Nuclear Information System (INIS)

    Wong, H.T.; Boehm, F.; Fisher, P.

    1991-01-01

    A xenon Time Projection Chamber with an active volume of 207 liters has been built to study 0ν and 2ν double beta decay in 136 Xe. The TPC has been installed in the Gotthard Tunnel Underground Laboratory, and is currently taking data with 5 atm of xenon enriched in 62.5% 136 Xe. The first 166 hours of data are presented. Based on this data set, we deduce a half-life limit of T(0 + → 0 + ) > 6.2 x 10 21 years for the 0ν mode, at a 90% C.L. (author)

  5. Xenon-133 retention in hepatic steatosis - correlation with liver biopsy in 45 patients: concise communication

    International Nuclear Information System (INIS)

    Ahmad, M.; Perrillo, R.P.; Sunwoo, Y.C.; Donati, R.M.

    1979-01-01

    This study presents the results of comparison of hepatic fat content with hepatic xenon retention in 45 patients. The degree of hepatic Xe-133 retention was measured during pulmonary ventilation studies. The amount of hepatic steatosis was graded 0 to 4+ on histologic liver sections obtained by needle or surgical biopsy. There was agreement between the amount of hepatic xenon retention determined scintigraphically and the degree of steatosis determined histologically. These results suggest that Xe-133 retention in the liver provides a simple means of evaluating fatty infiltration of the liver. The potential of this technique as a noninvasive means of investigating hepatic fatty infiltration is discussed

  6. Cryogenic readout for multiple VUV4 Multi-Pixel Photon Counters in liquid xenon

    Science.gov (United States)

    Di Giovanni, A.

    2018-03-01

    This work concerned the preliminary tests and characterization of a cryogenic preamplifier board for an array made of 16 S13370-3050CN (VUV4 family) Multi-Pixel Photon Counters manufactured by Hamamatsu and operated at liquid xenon temperature. The proposed prototype is based on the use of the Analog Devices AD8011 current feedback operational amplifier. The detector allows for single photon detection, making this device a promising choice for the future generation of neutrino and dark matter detectors based on liquid xenon targets.

  7. On electron attachment effect on characteristics of the DBD in chlorine and its mixtures with xenon

    Science.gov (United States)

    Avtaeva, S. V.

    2017-11-01

    The electron attachment effect on DBD characteristics in chlorine and its mixtures with xenon has been studied. Characteristics of the DBDs in pure chlorine and in xenon-chlorine mixtures with a chlorine fraction of 0.1-5% were modeled using the fluid model. It is shown that the electron attachment limits a magnitude of the DBD current, contributes to formation of multiple current spikes, appearance of a double layer near the dielectric surface and formation of XeCl* excimer molecules, and leads to a redistribution of the power deposited into the discharge: more power is deposited into ions and less power is deposited into electrons.

  8. Nonlinear control for core power of pressurized water nuclear reactors using constant axial offset strategy

    Directory of Open Access Journals (Sweden)

    Gholam Reza Ansarifar

    2015-12-01

    Full Text Available One of the most important operations in nuclear power plants is load following, in which an imbalance of axial power distribution induces xenon oscillations. These oscillations must be maintained within acceptable limits otherwise the nuclear power plant could become unstable. Therefore, bounded xenon oscillation is considered to be a constraint for the load following operation. In this paper, the design of a sliding mode control (SMC, which is a robust nonlinear controller, is presented. SMC is a means to control pressurized water nuclear reactor (PWR power for the load following operation problem in a way that ensures xenon oscillations are kept bounded within acceptable limits. The proposed controller uses constant axial offset (AO strategy to ensure xenon oscillations remain bounded. The constant AO is a robust state constraint for the load following problem. The reactor core is simulated based on the two-point nuclear reactor model with a three delayed neutron groups. The stability analysis is given by means of the Lyapunov approach, thus the control system is guaranteed to be stable within a large range. The employed method is easy to implement in practical applications and moreover, the SMC exhibits the desired dynamic properties during the entire output-tracking process independent of perturbations. Simulation results are presented to demonstrate the effectiveness of the proposed controller in terms of performance, robustness, and stability. Results show that the proposed controller for the load following operation is so effective that the xenon oscillations are kept bounded in the given region.

  9. Spatial kinetics in nuclear reactor systems. Chapter 4

    International Nuclear Information System (INIS)

    Owens, D.H.

    1980-01-01

    The problem of constructing a low-order linear lumped-parameter model of xenon-induced spatial power oscillations in a large, cylindrical nuclear power reactor to replace an (assumed known) nonlinear distributed parameter model is examined. Model expansion and finite difference methods are used together to provide a successful solution to the problem. (U.K.)

  10. Kinetic characteristics of the Dalat Nuclear Research Reactor

    Energy Technology Data Exchange (ETDEWEB)

    An, Tran Khac; Dien, Nguyen Nhi; Hien, Pham Duy [Nuclear Research Inst., Da Lat (Viet Nam); and others

    1994-10-01

    Kinetic characteristics of the reconstructed nuclear reactor in Dalat is investigated. Experimental parameters measured consist of: temperature coefficient of reactivity for water moderator, xenon poisoning, contribution of delayed photoneutrons induced by Be({gamma}, n) reactions and positive reactivity insertion behavior. (author). 6 refs. 4 figs.

  11. Kinetic characteristics of the Dalat Nuclear Research Reactor

    International Nuclear Information System (INIS)

    Tran Khac An; Nguyen Nhi Dien; Pham Duy Hien

    1994-01-01

    Kinetic characteristics of the reconstructed nuclear reactor in Dalat is investigated. Experimental parameters measured consist of: temperature coefficient of reactivity for water moderator, xenon poisoning, contribution of delayed photoneutrons induced by Be(γ, n) reactions and positive reactivity insertion behavior. (author). 6 refs. 4 figs

  12. Iodine, krypton and xenon retention efficiencies of silver impregnated silica gel media with different silver loadings and under different test conditions

    Energy Technology Data Exchange (ETDEWEB)

    Motes, B G; Fernandez, S J; Tkachyk, J W

    1983-02-01

    The purpose of an independent study conducted by Exxon Nuclear Idaho, Co. (ENICO) was to evaluate a silver impregnated silica gel adsorption medium associated with a radioiodine air sampler developed at Brookhaven National Laboratory (BNL). Specifically, ENICO's responsibility was to evaluate the iodine and noble gas retention efficiencies of the adsorption medium. The evaluation was comprised of a four-phase program: 1) test assemblies capable of challenging the silver silica gel filled adsorber canister with radioiodine species or noble gases at flow rates up to 10 scfm and relative humidities up to 83% were constructed; 2) more than 45 kgs of the 4 and 8% silver impregnated silica gel were prepared and characterized for particle size distribution, bulk silver content, bulk density, and silver content by particle size; 3) iodine species retention efficiencies of the silver silica gel were determined; and 4 krypton and xenon retention efficiencies were measured. The iodine species retention efficiencies were greater than 90% under most conditions. A combination of flow rates >5 scfm and 4% silver loaded silica gel reduced the methyl iodide retention efficiency to less than 90%. The retention efficiencies for both krypton and xenon were on the order of 8 x 10{sup -2}% and were not affected greatly by any test variable except test duration. A reduced retention efficiency with increased test durations indicates adsorption equilibrium may be established within five minutes. (author)

  13. Iodine, krypton and xenon retention efficiencies of silver impregnated silica gel media with different silver loadings and under different test conditions

    International Nuclear Information System (INIS)

    Motes, B.G.; Fernandez, S.J.; Tkachyk, J.W.

    1983-02-01

    The purpose of an independent study conducted by Exxon Nuclear Idaho, Co. (ENICO) was to evaluate a silver impregnated silica gel adsorption medium associated with a radioiodine air sampler developed at Brookhaven National Laboratory (BNL). Specifically, ENICO's responsibility was to evaluate the iodine and noble gas retention efficiencies of the adsorption medium. The evaluation was comprised of a four-phase program: 1) test assemblies capable of challenging the silver silica gel filled adsorber canister with radioiodine species or noble gases at flow rates up to 10 scfm and relative humidities up to 83% were constructed; 2) more than 45 kgs of the 4 and 8% silver impregnated silica gel were prepared and characterized for particle size distribution, bulk silver content, bulk density, and silver content by particle size; 3) iodine species retention efficiencies of the silver silica gel were determined; and 4 krypton and xenon retention efficiencies were measured. The iodine species retention efficiencies were greater than 90% under most conditions. A combination of flow rates >5 scfm and 4% silver loaded silica gel reduced the methyl iodide retention efficiency to less than 90%. The retention efficiencies for both krypton and xenon were on the order of 8 x 10 -2 % and were not affected greatly by any test variable except test duration. A reduced retention efficiency with increased test durations indicates adsorption equilibrium may be established within five minutes. (author)

  14. Quantification of in vivo metabolic kinetics of hyperpolarized pyruvate in rat kidneys using dynamic 13C MRSI.

    Science.gov (United States)

    Xu, Tao; Mayer, Dirk; Gu, Meng; Yen, Yi-Fen; Josan, Sonal; Tropp, James; Pfefferbaum, Adolf; Hurd, Ralph; Spielman, Daniel

    2011-10-01

    With signal-to-noise ratio enhancements on the order of 10,000-fold, hyperpolarized MRSI of metabolically active substrates allows the study of both the injected substrate and downstream metabolic products in vivo. Although hyperpolarized [1-(13)C]pyruvate, in particular, has been used to demonstrate metabolic activities in various animal models, robust quantification and metabolic modeling remain important areas of investigation. Enzyme saturation effects are routinely seen with commonly used doses of hyperpolarized [1-(13)C]pyruvate; however, most metrics proposed to date, including metabolite ratios, time-to-peak of metabolic products and single exchange rate constants, fail to capture these saturation effects. In addition, the widely used small-flip-angle excitation approach does not correctly model the inflow of fresh downstream metabolites generated proximal to the target slice, which is often a significant factor in vivo. In this work, we developed an efficient quantification framework employing a spiral-based dynamic spectroscopic imaging approach. The approach overcomes the aforementioned limitations and demonstrates that the in vivo (13)C labeling of lactate and alanine after a bolus injection of [1-(13)C]pyruvate is well approximated by saturatable kinetics, which can be mathematically modeled using a Michaelis-Menten-like formulation, with the resulting estimated apparent maximal reaction velocity V(max) and apparent Michaelis constant K(M) being unbiased with respect to critical experimental parameters, including the substrate dose, bolus shape and duration. Although the proposed saturatable model has a similar mathematical formulation to the original Michaelis-Menten kinetics, it is conceptually different. In this study, we focus on the (13)C labeling of lactate and alanine and do not differentiate the labeling mechanism (net flux or isotopic exchange) or the respective contribution of various factors (organ perfusion rate, substrate transport

  15. Oleate induces KATP channel-dependent hyperpolarization in mouse hypothalamic glucose-excited neurons without altering cellular energy charge.

    Science.gov (United States)

    Dadak, Selma; Beall, Craig; Vlachaki Walker, Julia M; Soutar, Marc P M; McCrimmon, Rory J; Ashford, Michael L J

    2017-03-27

    The unsaturated fatty acid, oleate exhibits anorexigenic properties reducing food intake and hepatic glucose output. However, its mechanism of action in the hypothalamus has not been fully determined. This study investigated the effects of oleate and glucose on GT1-7 mouse hypothalamic cells (a model of glucose-excited (GE) neurons) and mouse arcuate nucleus (ARC) neurons. Whole-cell and perforated patch-clamp recordings, immunoblotting and cell energy status measures were used to investigate oleate- and glucose-sensing properties of mouse hypothalamic neurons. Oleate or lowered glucose concentration caused hyperpolarization and inhibition of firing of GT1-7 cells by the activation of ATP-sensitive K + channels (K ATP ). This effect of oleate was not dependent on fatty acid oxidation or raised AMP-activated protein kinase activity or prevented by the presence of the UCP2 inhibitor genipin. Oleate did not alter intracellular calcium, indicating that CD36/fatty acid translocase may not play a role. However, oleate activation of K ATP may require ATP metabolism. The short-chain fatty acid octanoate was unable to replicate the actions of oleate on GT1-7 cells. Although oleate decreased GT1-7 cell mitochondrial membrane potential there was no change in total cellular ATP or ATP/ADP ratios. Perforated patch and whole-cell recordings from mouse hypothalamic slices demonstrated that oleate hyperpolarized a subpopulation of ARC GE neurons by K ATP activation. Additionally, in a separate small population of ARC neurons, oleate application or lowered glucose concentration caused membrane depolarization. In conclusion, oleate induces K ATP- dependent hyperpolarization and inhibition of firing of a subgroup of GE hypothalamic neurons without altering cellular energy charge. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

  16. Pulse Rise Time Characterization of a High Pressure Xenon Gamma Detector for use in Resolution Enhancement

    International Nuclear Information System (INIS)

    TROYER, G.L.

    2000-01-01

    High pressure xenon ionization chamber detectors are possible alternatives to traditional thallium doped sodium iodide (NaI(Tl)) and hyperpure germanium as gamma spectrometers in certain applications. Xenon detectors incorporating a Frisch grid exhibit energy resolutions comparable to cadmium/zinc/telluride (CZT) (e.g. 2% (at) 662keV) but with far greater sensitive volumes. The Frisch grid reduces the position dependence of the anode pulse risetimes, but it also increases the detector vibration sensitivity, anode capacitance, voltage requirements and mechanical complexity. We have been investigating the possibility of eliminating the grid electrode in high-pressure xenon detectors and preserving the high energy resolution using electronic risetime compensation methods. A two-electrode cylindrical high pressure xenon gamma detector coupled to time-to-amplitude conversion electronics was used to characterize the pulse rise time of deposited gamma photons. Time discrimination was used to characterize the pulse rise time versus photo peak position and resolution. These data were collected to investigate the effect of pulse rise time compensation on resolution and efficiency

  17. Local regulation of blood flow evaluated simultaneously by 133-xenon washout and laser Doppler flowmetry

    International Nuclear Information System (INIS)

    Engelhart, M.; Petersen, L.J.; Kristensen, J.K.

    1988-01-01

    The laser Doppler flowmeter and the 133-Xenon washout techniques of measuring cutaneous blood flow were compared for measuring the vasoconstrictor response of the hand during orthostatic maneuvres. Important discrepancies were detected for the two methods. When the hand was lowered by 40 cm a 40% decrease in blood flow was detected by the 133-Xenon method, while a 60% decrease was seen by the laser Doppler technique. Lowering the hand by 50 cm resulted in no further blood flow decrease when using the 133-Xenon method, but an 80% blood flow decrease was recorded with the laser Doppler method. A marked decrease in blood flow was recorded by the laser Doppler technique in hands that were sympathectomized or a hand that was subjected to a nerve blockade, strategies which should eliminate the orthostatic vasoconstrictor response of superficial cutaneous vessels. The 133-Xenon technique did not detect any blood flow changes in hands without sympathetic tone. We found the laser Doppler flowmetry technique unsatisfactory for measurement of blood flow changes that occur in nutritional vessels as this method measures total skin blood flow including non-capillary vessels

  18. Optimal Control Strategy Search Using a Simplest 3-D PWR Xenon Oscillation Simulator

    International Nuclear Information System (INIS)

    Yoichiro, Shimazu

    2004-01-01

    Power spatial oscillations due to the transient xenon spatial distribution are well known as xenon oscillation in large PWRs. When the reactor size becomes larger than the current design, then even radial oscillations can be also divergent. Even if the radial oscillation is convergent, when some control rods malfunction occurs, it is necessary to suppress the oscillation in as short time as possible. In such cases, optimal control strategy is required. Generally speaking the optimality search based on the modern control theory requires a lot of calculation for the evaluation of state variables. In the case of control rod malfunctions the xenon oscillation could be three dimensional. In such case, direct core calculations would be inevitable. From this point of view a very simple model, only four point reactor model, has been developed and verified. In this paper, an example of a procedure and the results for optimal control strategy search are presented. It is shown that we have only one optimal strategy within a half cycle of the oscillation with fixed control strength. It is also shown that a 3-D xenon oscillation introduced by a control rod malfunction can not be controlled by only one control step as can be done for axial oscillations. They might be quite strong limitations to the operators. Thus it is recommended that a strategy generator, which is quick in analyzing and easy to use, might be installed in a monitoring system or operator guiding system. (author)

  19. Production of fusion radionuclides: Molybdenum-99/ Iodine - 131 and Xenon-133

    International Nuclear Information System (INIS)

    Barrachina, M.; Carrillo, D.

    1982-01-01

    This report presents a new radiochemical method for industrial production of the radionuclides: molybdenum-99, iodine-131 and xenon-133. The above mentioned method based on the alkaline metathesis reaction of irradiated uranium (IV) fluoride, presents the best characteristics for the proposed objective. The study deals with the analysis of that reaction and the separation and purification processes. (Author) 71 refs

  20. Observation of electron multiplication in liquid xenon with a microstrip plate

    International Nuclear Information System (INIS)

    Policarpo, A.P.L.; Geltenbort, P.; Ferreira Marques, R.; Araujo, H.; Fraga, F.; Alves, M.A.; Fonte, P.; Lima, E.P.; Fraga, M.M.; Salete Leite, M.; Silander, K.; Onofre, A.; Pinhao, J.M.

    1995-01-01

    We report here on the observation of electron multiplication in liquid xenon in a microstrip chamber with an amplification factor of the order of 10. The measurements were carried out at a temperature between 208 and 215 K (liquid density of about 2.7 g/cm 3 ). (orig.)