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Sample records for hyperbaric oxygenation therapy

  1. Hyperbaric oxygen therapy

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/article/002375.htm Hyperbaric oxygen therapy To use the sharing features on this page, please enable JavaScript. Hyperbaric oxygen therapy uses a special pressure chamber to increase ...

  2. Hyperbaric Oxygen Therapy

    Science.gov (United States)

    ... hyperbaric oxygen therapy include serious infections, bubbles of air in your blood vessels, and wounds that won't heal as a ... following conditions: Anemia, severe Brain abscess Bubbles of air in your blood vessels (arterial gas embolism) Burn Decompression sickness Carbon monoxide ...

  3. Hyperbaric oxygen therapy reduces renal lactate production

    DEFF Research Database (Denmark)

    Nørlinger, Thomas S; Nielsen, Per Mose; Qi, Haiyun

    2017-01-01

    Intrarenal hypoxia is an acknowledged factor contributing to the development of diabetic nephropathy. Hyperbaric oxygen (HBO) therapy is a well-known adjuvant treatment for several medical conditions, such as decompression sickness, infections, and wound healing. The underlying metabolic response...

  4. Hyperbaric oxygen therapy for acute acoustic trauma.

    Science.gov (United States)

    Pilgramm, M; Schumann, K

    1985-01-01

    We conducted a study on the effect of hyperbaric oxygen therapy on 122 soldiers following acute acoustic trauma. The patients included in this study, after the effect of spontaneous recovery had largely been excluded, were randomly allocated to four treatment groups. The results of our studies show that hyperbaric oxygen therapy shortens the course of healing with respect to high-pitch perception dysacusis. The results of treatment after an observation period of 6 weeks is also more favorable when patients are treated with oxygen when compared to patients given infusions or vasoactive substances. Similarly, the use of hyperbaric oxygen therapy also reduces the frequency of relapse following discharge from hospital. In contrast, the vasoactive substance chosen in our studies (betahistine) failed to have a favorable effect on the course of healing. Our study has also shown that no method can compare with hyperbaric therapy in eliminating tinnitus following acoustic trauma.

  5. Hyperbaric Oxygen Therapy: Don't Be Misled

    Science.gov (United States)

    ... Products For Consumers Home For Consumers Consumer Updates Hyperbaric Oxygen Therapy: Don't Be Misled Share Tweet ... How HBOT Works What are the Risks No, hyperbaric oxygen therapy (HBOT) has not been clinically proven ...

  6. Hyperbaric oxygen therapy for sudden sensorineural hearing loss in divers.

    Science.gov (United States)

    Van Der Wal, A W; Van Ooij, P J A M; De Ru, J A

    2016-11-01

    Sudden sensorineural hearing loss in divers may be caused by either inner-ear barotrauma or inner-ear decompression sickness. There is no consensus on the best treatment option. This study aimed to evaluate the therapeutic value of hyperbaric oxygen therapy for sudden sensorineural hearing loss in divers. A literature review and three cases of divers with sudden sensorineural hearing loss treated with hyperbaric oxygen therapy are presented. Hyperbaric oxygen therapy resulted in hearing improvement in 80 per cent of patients: 39 per cent had hearing improvement and 41 per cent had full recovery. Hyperbaric oxygen therapy improved hearing in divers with sudden sensorineural hearing loss.

  7. Hyperbaric oxygen therapy improves cognitive functioning after brain injury

    Institute of Scientific and Technical Information of China (English)

    Su Liu; Guangyu Shen; Shukun Deng; Xiubin Wang; Qinfeng Wu; Aisong Guo

    2013-01-01

    Hyperbaric oxygen therapy has been widely applied and recognized in the treatment of brain injury;however, the correlation between the protective effect of hyperbaric oxygen therapy and changes of metabolites in the brain remains unclear. To investigate the effect and potential mechanism of hyperbaric oxygen therapy on cognitive functioning in rats, we established traumatic brain injury models using Feeney’s free fal ing method. We treated rat models with hyperbaric oxygen therapy at 0.2 MPa for 60 minutes per day. The Morris water maze test for spatial navigation showed that the average escape latency was significantly prolonged and cognitive function decreased in rats with brain injury. After treatment with hyperbaric oxygen therapy for 1 and 2 weeks, the rats’ spatial learning and memory abilities were improved. Hydrogen proton magnetic resonance spectroscopy analysis showed that the N-acetylaspartate/creatine ratio in the hippocampal CA3 region was sig-nificantly increased at 1 week, and the N-acetylaspartate/choline ratio was significantly increased at 2 weeks after hyperbaric oxygen therapy. Nissl staining and immunohistochemical staining showed that the number of nerve cells and Nissl bodies in the hippocampal CA3 region was significantly increased, and glial fibril ary acidic protein positive cells were decreased after a 2-week hyperbaric oxygen therapy treatment. Our findings indicate that hyperbaric oxygen therapy significantly im-proves cognitive functioning in rats with traumatic brain injury, and the potential mechanism is me-diated by metabolic changes and nerve cellrestoration in the hippocampal CA3 region.

  8. Hyperbaric oxygen therapy improves cognitive functioning after brain injury.

    Science.gov (United States)

    Liu, Su; Shen, Guangyu; Deng, Shukun; Wang, Xiubin; Wu, Qinfeng; Guo, Aisong

    2013-12-15

    Hyperbaric oxygen therapy has been widely applied and recognized in the treatment of brain injury; however, the correlation between the protective effect of hyperbaric oxygen therapy and changes of metabolites in the brain remains unclear. To investigate the effect and potential mechanism of hyperbaric oxygen therapy on cognitive functioning in rats, we established traumatic brain injury models using Feeney's free falling method. We treated rat models with hyperbaric oxygen therapy at 0.2 MPa for 60 minutes per day. The Morris water maze test for spatial navigation showed that the average escape latency was significantly prolonged and cognitive function decreased in rats with brain injury. After treatment with hyperbaric oxygen therapy for 1 and 2 weeks, the rats' spatial learning and memory abilities were improved. Hydrogen proton magnetic resonance spectroscopy analysis showed that the N-acetylaspartate/creatine ratio in the hippocampal CA3 region was significantly increased at 1 week, and the N-acetylaspartate/choline ratio was significantly increased at 2 weeks after hyperbaric oxygen therapy. Nissl staining and immunohistochemical staining showed that the number of nerve cells and Nissl bodies in the hippocampal CA3 region was significantly increased, and glial fibrillary acidic protein positive cells were decreased after a 2-week hyperbaric oxygen therapy treatment. Our findings indicate that hyperbaric oxygen therapy significantly improves cognitive functioning in rats with traumatic brain injury, and the potential mechanism is mediated by metabolic changes and nerve cell restoration in the hippocampal CA3 region.

  9. Hyperbaric oxygen therapy of spinal cord injury

    Directory of Open Access Journals (Sweden)

    Nitesh P Patel

    2017-01-01

    Full Text Available Spinal cord injury (SCI is a complex disease process that involves both primary and secondary mechanisms of injury and can leave patients with devastating functional impairment as well as psychological debilitation. While no curative treatment is available for spinal cord injury, current therapeutic approaches focus on reducing the secondary injury that follows SCI. Hyperbaric oxygen (HBO therapy has shown promising neuroprotective effects in several experimental studies, but the limited number of clinical reports have shown mixed findings. This review will provide an overview of the potential mechanisms by which HBO therapy may exert neuroprotection, provide a summary of the clinical application of HBO therapy in patients with SCI, and discuss avenues for future studies.

  10. Australian paediatric hyperbaric oxygen therapy 1998-2011.

    Science.gov (United States)

    Frawley, G; Bennett, M; Thistlethwaite, K; Banham, N

    2013-01-01

    For a large number of ischaemic, infective, inflammatory or traumatic conditions, hyperbaric oxygen therapy is either the only treatment or an adjunct that significantly reduces morbidity and mortality. The primary aim of this review is to identify clinical conditions treated in a paediatric population referred to Australian hyperbaric units. Secondary aims are to describe outcomes of treatment and detail any complications occurring during treatment or during transfer between units. This was a retrospective cohort study (January 1998-December 2011) of children treated at four Australian hyperbaric medical units. A total of 112 children underwent 1099 hyperbaric treatments for 14 indications. Ages were not normally distributed with a median age of 14 years (interquartile range 11-16; range 0.25-16 years). Treatments were completed as planned in 81.5% of cases with 25 patients' treatment terminated at the request of physicians, parents or patients. Complications relating to hyperbaric oxygen therapy occurred in 58 treatments (5.3%). Central nervous system oxygen toxicity occurred in 1:366 treatments. Our findings indicate that provision of hyperbaric oxygen therapy to children is feasible in major regional hyperbaric units and is associated with low complication rates. Management of children in an adult hyperbaric facility, however, requires significant cooperation between paediatric, intensive care and hyperbaric consultants, as the need for transfer to another hospital and prolonged transports often impacts on optimal ongoing surgical and intensive care management.

  11. Hyperbaric oxygen therapy for perineal Crohn's disease.

    Science.gov (United States)

    Noyer, C M; Brandt, L J

    1999-02-01

    Perineal lesions are a frequent and troublesome complication of Crohn's disease. Although there are various surgical and medical therapeutic regimens available to treat these lesions, all have significant associated morbidity, mortality, and toxicity. Recently, the beneficial effects of hyperbaric oxygen therapy (HBOT) have been described in patients with severe or refractory perineal disease, but the role of HBOT in larger groups or less severely affected patients has not yet been studied, nor has the minimum number of treatments required for initial or complete healing of perineal disease in this population been described. This article reviews the known and theoretical tissue effects of HBOT and discusses its potential role in treating patients with perineal Crohn's disease.

  12. Hyperbaric oxygen therapy improves colorectal anastomotic healing

    NARCIS (Netherlands)

    G.S.A. Boersema (Geesien); Z. Wu (Zhouqiao); L.F. Kroese; S. Vennix (Sandra); Y.M. Bastiaansen-Jenniskens (Yvonne); J.W. van Neck (Han); K.H. Lam; G.J. Kleinrensink (Gert Jan); J. Jeekel (Johannes); J.F. Lange (Johan F.)

    2016-01-01

    textabstractPurpose: Hyperbaric oxygen treatment (HBOT) has been found to improve the healing of poorly oxygenated tissues. This study aimed to investigate the influence of HBOT on the healing in ischemic colorectal anastomosis. Methods: Forty Wistar rats were randomly divided into a treatment group

  13. Mechanisms of action of hyperbaric oxygen therapy.

    Science.gov (United States)

    Camporesi, Enrico M; Bosco, Gerardo

    2014-01-01

    Therapeutic mechanisms of action for hyperbaric oxygen (HBO2) therapy are based on elevation of both the partial pressure of inspired O2 and of the hydrostatic pressure. This last mechanism contributes to a compression of all gas-filled spaces in the body (Boyle's Law) and is relevant to treat conditions where gas bubbles are present in the body and cause the disease (e.g., intravascular embolism; decompression sickness with intravascular or intra-tissue bubbles). However, the majority of patients treated with HBO2 do not suffer from bubble-induced injuries, but derive clinical improvements from the elevated O2 partial pressures. High O2 partial pressures in various tissues increase the production of reactive O2 species (ROS) and also of reactive nitrogen species (RNS) because of hyperoxia. Most controlled studies have verified that the clinical efficacy from HBO2 derives from modulation of intracellular transduction cascades, leading to synthesis of growth factors and promoting wound healing and ameliorating post-ischemic and post-inflammatory injuries.

  14. Hyperbaric oxygen therapy improves local microenvironment after spinal cord injury

    Institute of Scientific and Technical Information of China (English)

    Yang Wang; Shuquan Zhang; Min Luo; Yajun Li

    2014-01-01

    Clinical studies have shown that hyperbaric oxygen therapy improves motor function in patients with spinal cord injury. In the present study, we explored the mechanisms associated with the recovery of neurological function after hyperbaric oxygen therapy in a rat model of spinal cord injury. We established an acute spinal cord injury model using a modiifcation of the free-falling object method, and treated the animals with oxygen at 0.2 MPa for 45 minutes, 4 hours after injury. The treatment was administered four times per day, for 3 days. Compared with model rats that did not receive the treatment, rats exposed to hyperbaric oxygen had fewer apoptotic cells in spinal cord tissue, lower expression levels of aquaporin 4/9 mRNA and protein, and more NF-200 positive nerve ifbers. Furthermore, they had smaller spinal cord cavities, rapid recovery of somatosensory and motor evoked potentials, and notably better recovery of hindlimb motor function than model rats. Our ifndings indicate that hyperbaric oxygen therapy reduces apop-tosis, downregulates aquaporin 4/9 mRNA and protein expression in injured spinal cord tissue, improves the local microenvironment for nerve regeneration, and protects and repairs the spinal cord after injury.

  15. Hyperbaric oxygen therapy for treating acute surgical and traumatic wounds

    NARCIS (Netherlands)

    A. Eskes; D.T. Ubbink; M. Lubbers; C. Lucas; H. Vermeulen

    2010-01-01

    Hyperbaric oxygen therapy (HBOT) is used as a treatment for acute wounds (such as those arising from surgery and trauma) however the effects of HBOT on wound healing are unclear. To determine the effects of HBOT on the healing of acute surgical and traumatic wounds. We searched the Cochrane Wounds G

  16. Hyperbaric oxygen therapy in spontaneous brain abscess patients

    DEFF Research Database (Denmark)

    Bartek, Jiri; Jakola, Asgeir S; Skyrman, Simon

    2016-01-01

    BACKGROUND: There is a need to improve outcome in patients with brain abscesses and hyperbaric oxygen therapy (HBOT) is a promising treatment modality. The objective of this study was to evaluate HBOT in the treatment of intracranial abscesses. METHOD: This population-based, comparative cohort...

  17. Hyperbaric oxygen therapy for people with autism spectrum disorder (ASD).

    Science.gov (United States)

    Xiong, Tao; Chen, Hongju; Luo, Rong; Mu, Dezhi

    2016-10-13

    The rising prevalence of autism spectrum disorder (ASD) has increased the need for evidence-based treatments to lessen the impact of symptoms. Presently, no therapies are available to effectively treat individuals with all of the symptoms of this disorder. It has been suggested that hyperbaric oxygen therapy may alleviate the biochemical dysfunction and clinical symptoms of ASD. To determine whether treatment with hyperbaric oxygen:1. improves core symptoms of ASD, including social communication problems and stereotypical and repetitive behaviors;2. improves noncore symptoms of ASD, such as challenging behaviors;3. improves comorbid states, such as depression and anxiety; and4. causes adverse effects. On 10 December 2015, we searched CENTRAL, Ovid MEDLINE, Embase, and 15 other databases, four of which were Chinese language databases. We also searched multiple trial and research registers. We selected randomized controlled trials (RCTs) and quasi-RCTs of any dose, duration, and frequency for hyperbaric oxygen therapy compared with no treatment or sham treatment for children and adults with ASD. We used standard methodological procedures expected by The Cochrane Collaboration, in that three review authors independently selected studies, assessed them for risk of bias, and extracted relevant data. We also assessed the quality of the evidence by using the GRADE approach. We included one trial with a total of 60 children with a diagnosis of ASD who randomly received hyperbaric oxygen therapy or a sham treatment. Using GRADE criteria, we rated the quality of the evidence as low because of the small sample size and wide confidence intervals (CIs). Other problems included selection bias and short duration or follow-up.Overall, study authors reported no improvement in social interaction and communication, behavioral problems, communication and linguistic abilities, or cognitive function. With regard to the safety of hyperbaric oxygen therapy (adverse events), they reported

  18. Hyperbaric oxygen therapy for idiopathic sudden sensorineural hearing loss.

    Science.gov (United States)

    Murphy-Lavoie, H; Piper, S; Moon, R E; Legros, T

    2012-01-01

    Idiopathic sudden sensorineural hearing loss (ISSHL) is the newest indication approved by the Undersea and Hyperbaric Medical Society's Hyperbaric Oxygen Therapy Committee. Idiopathic sudden sensorineural hearing loss appears to be characterized by hypoxia in the perilymph and therefore the scala tympani and the organ of Corti. A review of the literature reveals more than 100 publications evaluating the use of hyperbaric oxygen (HBO2) for the treatment of ISSHL, including eight randomized controlled trials. The best and most consistent results are obtained when HBO2 is initiated within two weeks of symptom onset and combined with corticosteroid treatment. The average hearing gain is 19.3 dB for moderate hearing loss and 37.7 dB for severe cases. This improvement brings hearing deficits from the moderate/severe range into the slight/no impairment range. This is a significant gain that can markedly improve a patient's quality of life, both clinically and functionally.

  19. Hyperbaric oxygen in chronic traumatic brain injury: oxygen, pressure, and gene therapy.

    Science.gov (United States)

    Harch, Paul G

    2015-01-01

    Hyperbaric oxygen therapy is a treatment for wounds in any location and of any duration that has been misunderstood for 353 years. Since 2008 it has been applied to the persistent post-concussion syndrome of mild traumatic brain injury by civilian and later military researchers with apparent conflicting results. The civilian studies are positive and the military-funded studies are a mixture of misinterpreted positive data, indeterminate data, and negative data. This has confused the medical, academic, and lay communities. The source of the confusion is a fundamental misunderstanding of the definition, principles, and mechanisms of action of hyperbaric oxygen therapy. This article argues that the traditional definition of hyperbaric oxygen therapy is arbitrary. The article establishes a scientific definition of hyperbaric oxygen therapy as a wound-healing therapy of combined increased atmospheric pressure and pressure of oxygen over ambient atmospheric pressure and pressure of oxygen whose main mechanisms of action are gene-mediated. Hyperbaric oxygen therapy exerts its wound-healing effects by expression and suppression of thousands of genes. The dominant gene actions are upregulation of trophic and anti-inflammatory genes and down-regulation of pro-inflammatory and apoptotic genes. The combination of genes affected depends on the different combinations of total pressure and pressure of oxygen. Understanding that hyperbaric oxygen therapy is a pressure and oxygen dose-dependent gene therapy allows for reconciliation of the conflicting TBI study results as outcomes of different doses of pressure and oxygen.

  20. [Hyperbaric Oxygenation - utility in intensive therapy - part 1].

    Science.gov (United States)

    Lampl, Lorenz; Frey, Günter; Fischer, Dietmar; Fischer, Silke

    2009-09-01

    Hyperbaric Oxygenation (HBO) is a medical treatment, in which a patient breathes 100 % oxygen inside a treatment chamber at a pressure higher than at sea level. The indication for HBO has to be considered whenever gas bubbles present in tissue or blood circulation (decompression sickness, gas embolism) or when a high oxygen delivery is of crucial importance (CO-intoxication, selected anaerobic soft tissue infections). HBO must never be considered as a substitute for conventional surgical or intensive care therapy, but as an adjuvant of (potentially) crucial importance.

  1. Acute pulmonary edema secondary to hyperbaric oxygen therapy

    Science.gov (United States)

    Obiagwu, Chukwudi; Paul, Vishesh; Chadha, Sameer; Hollander, Gerald; Shani, Jacob

    2015-01-01

    Hyperbaric oxygen therapy (HBOT) has been shown to be effective in the treatment of diabetic ulcers, air embolism, carbon monoxide poisoning and gas gangrene with minimal adverse effects. Very few cases of HBOT causing acute pulmonary edema (PE) has been described; with a study on dogs suggesting that a complication of this therapy could be PE. We describe the case of an 80-year-old man with a history of stable systolic heart failure and diabetes mellitus presenting with acute PE following treatment with HBOT for diabetic foot. PMID:25988073

  2. Hyperbaric oxygen therapy for treatment of children with autism: a systematic review of randomized trials

    OpenAIRE

    Ghanizadeh Ahmad

    2012-01-01

    Abstract There is a controversy about the efficacy of hyperbaric oxygen (HBO) therapy for the treatment of autism. This study systematically reviews the current evidences for treating of autism with HBO therapy. According to PRISMA guidelines for a systematic review, the databases of MEDLINE/Pubmed, Google Scholar, and Randomised Controlled Trials in Hyperbaric Medicine were electronically searched. In addition, medical subject heading terms and text words for hyperbaric oxygen therapy and au...

  3. Study the effect of hyperbaric oxygen therapy in Egyptian autistic ...

    African Journals Online (AJOL)

    Farida El-baz

    2014-02-20

    . Many of these ..... 1.5 atmospheres (atm) and 100% oxygen, and found that chil- dren had .... Hyperbaric oxygenation ameliorates indomethacin-induced enter- · opathy in rats by ... kin-10-dependent mechanism. Crit Care ...

  4. Iatrogenic systemic air embolism treated with hyperbaric oxygen therapy

    DEFF Research Database (Denmark)

    Jørgensen, Thomas Bech; Sørensen, Allan Martini Ibsen; Jansen, Erik C.

    2008-01-01

    Air embolism is a rare and potentially severe complication of surgical and invasive procedures. Emboli large enough to produce symptoms require immediate treatment because of the risk of 'gas lock' in the right side of the heart and subsequent circulatory failure. If air is transmitted to the art...... to the arterial circulation through a shunt, it may cause cerebral emboli with neurological symptoms. We present two cases with venous air emboli and concurrent cerebral arterial emboli. Both patients were successfully treated with hyperbaric oxygen therapy Udgivelsesdato: 2008/4...

  5. The role of hyperbaric oxygen therapy in sports medicine.

    Science.gov (United States)

    Babul, S; Rhodes, E C

    2000-12-01

    During the past decade, we have seen a growing number of individuals participating in sport and recreational activities. All indications show an increase in sport participation at every age level. However, the number of sport and recreational injuries as a result of this increase has also risen. Unfortunately, a primary cost related to injury recovery is the time lost from participating in and resuming normal functional activity. This has compelled health care professionals to seek more efficient and effective therapeutic interventions in treating such injuries. Hyperbaric oxygen (HBO) therapy may serve to provide a means of therapy to facilitate a speedier resumption to pre-injury activity levels as well as improve the short and long term prognosis of the injury. Although a growing interest in sports medicine is becoming evident in the literature, the use of HBO as an intervention in this field has received a great deal of cynicism. To date, numerous professional athletic teams, including hockey (NHL), football (NFL), basketball (NBA) and soccer (MLS), utilise and rely on the use of HBO as adjuvant therapy for numerous sports-related injuries acquired from playing competitive sports. However, to date, very little has been published on the application benefits of hyperbaric therapy and sports injuries. The majority of clinical studies examining the efficacy of HBO in treating soft tissue injuries have been limited in their sample size and study design. Further research needs to be conducted suggesting and validating the significant effects of this treatment modality and further grounding its importance in sports medicine.

  6. Hyperbaric oxygen therapy and the possibility of ocular complications or contraindications.

    Science.gov (United States)

    McMonnies, Charles W

    2015-03-01

    Hyperbaric oxygen therapy increases oxygen pressure and the concentration of reactive oxygen species in blood and tissues. Increased oxygen pressure may be beneficial in some diseases, such as in the treatment of diabetic leg ulcers and diabetic retinopathy; however, due to their cytotoxic properties, an excess of reactive oxygen species in tissues and/or deficiencies in antioxidant activity, may contribute to complications of hyperbaric oxygen therapy, such as cataract. This review examines the possibility that increased tissue concentrations of reactive oxygen species may also exacerbate other ocular diseases. For example, reactive oxygen species and deficiencies in antioxidant activities contribute to the pathogenetic processes in keratoconus. Such impact may be exacerbated by exposure to additional reactive oxygen species during hyperbaric oxygen therapy. The senescent eye may be particularly prone to oxidative damage as exemplified by conditions such as macular degeneration and cataract. Because of its high consumption of oxygen, the retina is particularly susceptible to oxidative stress, which plays a major role in retinopathy. For example, under normal conditions age-related macular degeneration involves oxidative stress and death of the retinal pigment epithelial cells. Hyperbaric oxygen therapy may exacerbate these processes. In addition to cataract, age-related macular degeneration and keratoconus, there may be other ocular diseases for which exposure to hyperbaric oxygen therapy-related oxidative stress may be significantly adverse. In all such cases, careful pre-examination and evaluation of the potential risk and benefit from this form of therapy appears to be warranted. Unless it could interfere with the benefits of hyperbaric oxygen therapy, antioxidant dietary supplementation may be indicated in conjunction with any hyperbaric oxygen therapy, when there are co-existing diseases for which oxidative stress could have significantly adverse side effects

  7. The place of hyperbaric oxygen therapy and ozone therapy in sudden hearing loss.

    Science.gov (United States)

    Ergun Taşdöven, Gülin; Derin, Alper Tunga; Yaprak, Neslihan; Özçağlar, Hasan Ümit

    It is difficult to evaluate the effect of drugs clinically used for idiopathic sudden sensorineural hearing loss, mainly because its underlying mechanism remains unknown. This study assessed the efficacy of hyperbaric oxygen therapy or ozone therapy in the treatment of idiopathic sudden sensorineural hearing loss, when either therapy was included with steroid treatment. A retrospective analysis examined 106 patients with idiopathic sudden sensorineural hearing loss seen between January 2010 and June 2012. Those with an identified etiology were excluded. The patients were divided into three treatment groups: oral steroid only (n=65), oral steroid+hyperbaric oxygen (n=26), and oral steroid+ozone (n=17). Treatment success was assessed using Siegel criteria and mean gains using pre- and post-treatment audiograms. The highest response rate to treatment was observed in the oral steroid+ozone therapy group (82.4%), followed by the oral steroid+hyperbaric oxygen (61.5%), and oral steroid groups (50.8%). There were no significant differences in the response to treatment between the oral steroid and oral steroid+hyperbaric oxygen groups (phearing loss was low. It was statistically ascertained that adding hyperbaric oxygen or ozone therapy to the treatment contributed significantly to treatment success. Copyright © 2016 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved.

  8. Hyperbaric oxygen therapy for intensive care patients: position statement by the European Committee for Hyperbaric Medicine.

    Science.gov (United States)

    Mathieu, Daniel; Ratzenhofer-Komenda, Beatrice; Kot, Jacek

    2015-03-01

    Many of the accepted indications for hyperbaric oxygen treatment (HBOT) may occur in critically ill patients. HBOT itself may cause a number of physiological changes which may further compromise the patient's state. Guidelines on the management of critically ill patients in a hyperbaric facility have been founded on the conclusions of the 2007 European Committee for Hyperbaric Medicine (ECHM) meeting. With regard to patient management, HBOT should be included in the overall care of ICU patients only after a risk/benefit assessment related to the specifics of both the hyperbaric centre and the patient's clinical condition and should not delay or interrupt their overall management. Neither patient monitoring nor treatment should be altered or stopped due to HBOT, and any HBOT effects must be strictly evaluated and appropriately mitigated. With regard to the hyperbaric facility itself, the hyperbaric chamber should be specifically designed for ICU patients and should be fully equipped to allow continuation of patient monitoring and treatment. The hyperbaric chamber ideally should be located in, or around the immediate vicinity of the ICU, and be run by a sufficiently large and well-trained team of physicians, nurses, chamber operators and technicians. All devices to be introduced into the chamber should be evaluated, tested and acknowledged as safe for use in a hyperbaric environment and all procedures (standard and emergency) should be tested and written before being implemented.

  9. Hyperbaric oxygen therapy in sudden sensorineural hearing loss following spinal anesthesia: case reports.

    Science.gov (United States)

    Carneiro, Sandra N; Guerreiro, Ditza V; Cunha, Anita M; Camacho, Óscar F; Aguiar, Isabel C

    2016-01-01

    The management of sudden sensorineural hearing loss following spinal anesthesia is currently an open problem. Several strategies have been used with variable results and, to the best of our knowledge, there are no prior accounts in the literature on the use of hyperbaric oxygen therapy in the treatment of this complication. We report two cases of acute onset of unilateral hearing loss after spinal anesthesia, with significantly improved results after hyperbaric oxygen therapy. A hypothesis on the possible mechanism behind this complication is discussed. A relation is established between hyperbaric oxygen therapy and this hypothetical mechanism, in order to explain successful results in the reported cases.

  10. Hyperbaric oxygen therapy promotes neurogenesis: where do we stand?

    Directory of Open Access Journals (Sweden)

    Mu Jun

    2011-06-01

    Full Text Available Abstract Neurogenesis in adults, initiated by injury to the central nervous system (CNS presents an autologous repair mechanism. It has been suggested that hyperbaric oxygen therapy (HBOT enhances neurogenesis which accordingly may improve functional outcome after CNS injury. In this present article we aim to review experimental as well as clinical studies on the subject of HBOT and neurogenesis. We demonstrate hypothetical mechanism of HBOT on cellular transcription factors including hypoxia-inducible factors (HIFs and cAMP response element binding (CREB. We furthermore reveal the discrepancy between experimental findings and clinical trials in regards of HBOT. Further translational preclinical studies followed by improved clinical trials are needed to elucidate potential benefits of HBOT.

  11. Effect of hyperbaric oxygen therapy combined with autologous platelet concentrate applied in rabbit fibula fraction healing

    Directory of Open Access Journals (Sweden)

    Paulo Cesar Fagundes Neves

    2013-09-01

    Full Text Available OBJECTIVES: The purpose is to study the effects of hyperbaric oxygen therapy and autologous platelet concentrates in healing the fibula bone of rabbits after induced fractures. METHODS: A total of 128 male New Zealand albino rabbits, between 6-8 months old, were subjected to a total osteotomy of the proximal portion of the right fibula. After surgery, the animals were divided into four groups (n = 32 each: control group, in which animals were subjected to osteotomy; autologous platelet concentrate group, in which animals were subjected to osteotomy and autologous platelet concentrate applied at the fracture site; hyperbaric oxygen group, in which animals were subjected to osteotomy and 9 consecutive daily hyperbaric oxygen therapy sessions; and autologous platelet concentrate and hyperbaric oxygen group, in which animals were subjected to osteotomy, autologous platelet concentrate applied at the fracture site, and 9 consecutive daily hyperbaric oxygen therapy sessions. Each group was divided into 4 subgroups according to a pre-determined euthanasia time points: 2, 4, 6, and 8 weeks postoperative. After euthanasia at a specific time point, the fibula containing the osseous callus was prepared histologically and stained with hematoxylin and eosin or picrosirius red. RESULTS: Autologous platelet concentrates and hyperbaric oxygen therapy, applied together or separately, increased the rate of bone healing compared with the control group. CONCLUSION: Hyperbaric oxygen therapy and autologous platelet concentrate combined increased the rate of bone healing in this experimental model.

  12. Prognostic factors for idiopathic sudden sensorineural hearing loss treated with hyperbaric oxygen therapy and intravenous steroids.

    Science.gov (United States)

    Hosokawa, S; Sugiyama, K; Takahashi, G; Takebayashi, S; Mineta, H

    2017-01-01

    This study evaluated the prognosis of idiopathic sudden sensorineural hearing loss when treated with hyperbaric oxygen therapy and intravenous steroids. The clinical data for 334 patients with idiopathic sudden sensorineural hearing loss treated by hyperbaric oxygen therapy and intravenous steroids at our hospital were retrospectively reviewed. These data included the initial averaged five-frequency hearing level, patient age, interval between onset of symptoms and treatment, vertigo as a complication, and co-existence of diabetes mellitus. The overall improvement rate was 69.2 per cent, including better improvement (25.5 per cent), good improvement (21.0 per cent) and fair improvement (22.7 per cent). Hyperbaric oxygen therapy appears to confer a significant additional therapeutic benefit when used in combination with steroid therapy for idiopathic sudden sensorineural hearing loss. If performed early, hyperbaric oxygen therapy may bring about hearing improvement in many patients who are unresponsive to initial therapy.

  13. Hyperbaric Oxygen Therapy for Radiation-Induced Cystitis and Proctitis

    Energy Technology Data Exchange (ETDEWEB)

    Oliai, Caspian; Fisher, Brandon; Jani, Ashish; Wong, Michael; Poli, Jaganmohan; Brady, Luther W. [Department of Radiation Oncology, Drexel University College of Medicine, Philadelphia, Pennsylvania (United States); Komarnicky, Lydia T., E-mail: lydia.komarnicky-kocher@drexelmed.edu [Department of Radiation Oncology, Drexel University College of Medicine, Philadelphia, Pennsylvania (United States)

    2012-11-01

    Purpose: To provide a retrospective analysis of the efficacy of hyperbaric oxygen therapy (HBOT) for treating hemorrhagic cystitis (HC) and proctitis secondary to pelvic- and prostate-only radiotherapy. Methods and Materials: Nineteen patients were treated with HBOT for radiation-induced HC and proctitis. The median age at treatment was 66 years (range, 15-84 years). The range of external-beam radiation delivered was 50.0-75.6 Gy. Bleeding must have been refractory to other therapies. Patients received 100% oxygen at 2.0 atmospheres absolute pressure for 90-120 min per treatment in a monoplace chamber. Symptoms were retrospectively scored according to the Late Effects of Normal Tissues-Subjective, Objective, Management, Analytic (LENT-SOMA) scale to evaluate short-term efficacy. Recurrence of hematuria/hematochezia was used to assess long-term efficacy. Results: Four of the 19 patients were lost to follow-up. Fifteen patients were evaluated and received a mean of 29.8 dives: 11 developed HC and 4 proctitis. All patients experienced a reduction in their LENT-SOMA score. After completion of HBOT, the mean LENT-SOMA score was reduced from 0.78 to 0.20 in patients with HC and from 0.66 to 0.26 in patients with proctitis. Median follow-up was 39 months (range, 7-70 months). No cases of hematuria were refractory to HBOT. Complete resolution of hematuria was seen in 81% (n = 9) and partial response in 18% (n = 2). Recurrence of hematuria occurred in 36% (n = 4) after a median of 10 months. Complete resolution of hematochezia was seen in 50% (n = 2), partial response in 25% (n = 1), and refractory bleeding in 25% (n = 1). Conclusions: Hyperbaric oxygen therapy is appropriate for radiation-induced HC once less time-consuming therapies have failed to resolve the bleeding. In these conditions, HBOT is efficacious in the short and long term, with minimal side effects.

  14. Does hyperbaric oxygen therapy prevent airway anastomosis from breakdown?

    NARCIS (Netherlands)

    Dickhoff, C.; Daniels, J.M.; Brink, A. van den; Paul, M.A.; Verhagen, A.F.T.M.

    2015-01-01

    Ischemia with subsequent necrosis of anastomoses, after central airway resection and reconstruction, remains a feared complication for thoracic surgeons and their patients. To date, there is no evidence to support the use of hyperbaric oxygen in the prevention of necrosis of airway reconstructions i

  15. Randomized Trial of Hyperbaric Oxygen Therapy for Children with Autism

    Science.gov (United States)

    Granpeesheh, Doreen; Tarbox, Jonathan; Dixon, Dennis R.; Wilke, Arthur E.; Allen, Michael S.; Bradstreet, James Jeffrey

    2010-01-01

    Autism Spectrum Disorders (ASDs) are characterized by the presence of impaired development in social interaction and communication and the presence of a restricted repertoire of activity and interests. While numerous treatments for ASDs have been proposed, very few have been subjected to rigorous scientific investigation. Hyperbaric oxygen therapy…

  16. Delayed neuropsychiatric syndrome after carbon monoxide poisoning: inclusion of hyperbaric oxygen therapy in the recovery protocol

    Directory of Open Access Journals (Sweden)

    Dante Lo Pardo

    2016-06-01

    Full Text Available The delayed neuropsychiatric syndrome can arise in the period from 4 days to 5 weeks following carbon monoxide poisoning, and is characterized by neuropsychological deficits, which in some cases become chronic. This case report describes an adult female who apparently suffered self-inflicted carbon monoxide poisoning. She was not treated with hyperbaric oxygen and developed delayed sequelae on day 20. The treatment started with 40 sessions of hyperbaric oxygen therapy and subsequently with neuropsychological rehabilitation and physiotherapy. The treatment resulted in a progressive and almost complete physical and psychological recovery as evidenced by neuropsychometric tests and diagnostic imaging performed in the follow-up. Recovery was attributed to hyperbaric oxygen therapy. Although further research is required, we propose hyperbaric oxygen therapy also in the recovery protocol in the treatment of delayed neuropsychiatric syndrome.

  17. Alterations in taste perception as a result of hyperbaric oxygen therapy.

    Science.gov (United States)

    Hartman-Petrycka, Magdalena; Knefel, Grzegorz; Lebiedowska, Agata; Kosmala, Joanna; Klimacka-Nawrot, Ewa; Kawecki, Marek; Nowak, Mariusz; Błońska-Fajfrowska, Barbara

    2016-12-01

    The present study evaluates the effect of hyperbaric oxygen therapy on taste sensitivity, hedonic perception of taste, and food preferences. The studied groups included 197 people in total (79 in the study group; 118 in the control group). All patients from the study group were treated with hyperbaric oxygen therapy due to chronic non-healing wounds. The control group consisted of healthy people, who did not receive hyperbaric oxygen therapy. The taste intensity, recognition thresholds, and hedonic perception were examined using gustatory tests. The aqueous solutions of sucrose for sweet, sodium chloride for salty, citric acid for sour, quinine hydrochloride for bitter, and monosodium glutamate for umami taste were used. The participants fulfilled the questionnaire to examine pleasure derived from eating certain types of dishes. Gustatory tests and analyses of the pleasure derived from eating in the study group were carried out before the first exposure to hyperbaric oxygen and then at the end of therapy, after at least 25 sessions of treatment. In the control group, examination of perception of taste sensations was conducted only once. The results of comparing patients with non-healing wounds with healthy people are characterized by reduced taste sensitivity. After participation in hyperbaric oxygen therapy, the improvement in perception of taste sensations and changes in hedonic evaluation have occurred among patients with non-healing wounds. In terms of food preference, a decreased desire for eating sweet desserts, chocolate, and crisps was observed in those patients who received hyperbaric oxygen therapy.

  18. Application of hyperbaric oxygen therapy to osteoradionecrosis of the mandible

    Energy Technology Data Exchange (ETDEWEB)

    Sano, Kazuo; Yoshida, Shinichi; Ninomiya, Hidenori; Sekine, Joji; Michael, B.P.; Inokuchi, Tsugio (Nagasaki Univ. (Japan). School of Dentistry); Goto, Shinichi; Sumikawa, Koji

    1994-11-01

    Five cases of osteoradionecrosis (ORN) of the mandible were treated by hyperbaric oxygen therapy (HBO). In four cases, sequestrectomy in combination with HBO was performed. Furthermore, one of these cases underwent iliac bone grafting and HBO to correct mandibular discontinuity. One case underwent HBO after insertion of an implant into the irradiated mandible. Primary sites, with the histological diagnosis of the tumor and irradiation dose were: tonsil-squamous cell carcinoma (SCC), Linac X-ray 60 Gy; hard palate-malignant pleomorphic adenoma, Tele [sup 60]Co 50 Gy; floor of the mouth-SCC, Tele [sup 60]Co 38 Gy and [sup 198]Au grain 98 Gy; tonsil-SCC, Tele [sup 60]Co 60 Gy; tongue-SCC, Linac X-ray 40 Gy. ORN appeared in these five cases 3 years, 24 years, 8 months, 1.5 years and 10 years after irradiation, respectively. HBO was performed under the condition of 2.8 ATA for 60 minutes and the patients were given pure oxygen (51/min) using a reservoir mask. All five cases were successfully treated. Otitis, one of the side effects of HBO, occurred in one case. It was managed by puncture of the tympanic membrane. As ORN is caused by hypoxia of the bone and surrounding tissues, HBO is considered to be one of the basic treatment methods for this condition. (author).

  19. Delayed neuropsychiatric syndrome after carbon monoxide poisoning: inclusion of hyperbaric oxygen therapy in the recovery protocol

    OpenAIRE

    Dante Lo Pardo; Davide Amedola; Giuliana Senatore; Alberto Damiano; Gabriela Pezzuti; Nicola Pugliese; Gianpiero Locatelli; Alfredo Siani; Nicola Maria Vitola

    2016-01-01

    The delayed neuropsychiatric syndrome can arise in the period from 4 days to 5 weeks following carbon monoxide poisoning, and is characterized by neuropsychological deficits, which in some cases become chronic. This case report describes an adult female who apparently suffered self-inflicted carbon monoxide poisoning. She was not treated with hyperbaric oxygen and developed delayed sequelae on day 20. The treatment started with 40 sessions of hyperbaric oxygen therapy and subsequently with ne...

  20. The Effects of Hyperbaric Oxygen Therapy Against Streptomycin Ototoxicity

    Directory of Open Access Journals (Sweden)

    Salih Bakir

    2013-10-01

    Full Text Available Aim: Hyperbaric oxygen (HBO is an important adjuvant therapy and being increasingly used in the treatment of various disorders because of having an important antioxidant activity. This experimental study was designed to determine the possible protective effect of HBO therapy on streptomycin-induced ototoxicity. Material and Method: Twenty-eight adult Wistar albino rats were divided into four groups: Streptomycin (n=7, saline (n=7, HBO (n=7, and streptomycin plus HBO (n=7. The HBO administered rats were placed into a large pressure chamber and received 100% oxygene at 2.5 atmosphere absolute for 60 minutes per day in a period of seven days. Rats were tested with DPOAE (Distortion Product Otoacoustic Emissions in the beginning and the end of study. The animals in all groups were sacrificed under general anesthesia on the seventh day. Biopsy specimens from inner ear were stored for histopathologic examination with hematoxylin and eosin (H&E under light microscopy. Results: Outer hair cells shown by light microscopic images were mostly preserved in control and HBO group. DPOAE measurements revealed no significant differences between the beginning and the end (p>0.05. Streptomycin and streptomycin plus HBO treated rats showed loss of hair cells and auditory functions significantly (p<0.05. Between the groups of streptomycin and streptomycin plus HBO; there was no statistically significance according to the analysis of the histopathological scores and DPgram results (p>0.05. Discussion: HBO has probably no harmful effect on hair cells. But it seems to be not beneficial in a streptomycin-induced cochlear damage rat model.

  1. Clinical evolution of mediastinitis in patients undergoing adjuvant hyperbaric oxygen therapy after coronary artery bypass surgery

    Science.gov (United States)

    do Egito, Julyana Galvão Tabosa; Abboud, Cely Saad; de Oliveira, Aline Pâmela Vieira; Máximo, Carlos Alberto Gonçalves; Montenegro, Carolina Moreira; Amato, Vivian Lerner; Bammann, Roberto; Farsky, Pedro Silvio

    2013-01-01

    ABSTRACT Objective: To evaluate the use of hyperbaric oxygen therapy as an adjunctive treatment in mediastinitis after coronary artery bypass surgery. Methods: This is a retrospective descriptive study, performed between October 2010 and February 2012. Hyperbaric oxygen therapy was indicated in difficult clinical management cases despite antibiotic therapy. Results: We identified 18 patients with mediastinitis during the study period. Thirty three microorganisms were isolated, and polymicrobial infection was present in 11 cases. Enterobacteriaceae were the most prevalent pathogens and six were multi-resistant agents. There was only 1 hospital death, 7 months after the oxygen therapy caused by sepsis, unrelated to hyperbaric oxygen therapy. This treatment was well-tolerated. Conclusion: The initial data showed favorable clinical outcomes. PMID:24136762

  2. Hyperbaric Oxygen Therapy in the Treatment of Chronic Mild-Moderate Blast-Induced Traumatic Brain Injury PCS and PTSD

    Science.gov (United States)

    2015-10-01

    Award Number: W81XWH-10-1-0962 TITLE: Hyperbaric Oxygen therapy in the Treatment of Chronic Mild-Moderate Blast-Induced Traumatic Brain Injury...Annual 3. DATES COVERED (From – To) 30Sep2014 - 29Sep2015 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER W81XWH-10-1-0962 Hyperbaric Oxygen therapy in...post- hyperbaric oxygen treatment. Four additional subjects have been screened in October 2015 and nine are awaiting first appointment for

  3. Adverse reactions of hyperbaric oxygen therapy - case description of a generalised seizure

    Directory of Open Access Journals (Sweden)

    Grobelska Kinga

    2016-03-01

    Full Text Available Hyperbaric oxygen therapy (HBOT is a safe treatment, provided fulfilling certain rules of patient qualifications to treatment, as well as supervision over the course of therapy by qualified medical staff. Side effects reported in the literature are rare, and are usually mild and transient. Professional medical staff allows minimising the adverse events occurrence. The scale of complications is unknown, especially in Polish hyperbaric center. Careful analysis could be used to develop prevention procedures for patients of hyperbaric oxygen therapy. Hyperbaric Oxygen Centre and Wound Treatment in Bydgoszcz during 28 months performed hyperbaric oxygen therapy (HBOT in case of 423 patients. During this period, adverse events occurred occasionally. 17 cases have been reported. Authors described study case 77 year-old patient who was admitted due to non-healing wound-left lower abdomen (state after radiotherapy. During the fourth session, on decompression phase patient have had a generalized seizure (tonic-clonic. The decompression was stopped, the oxygen supply was disconnected but only after the drug administration seizures terminated. The most likely causative agent of the adverse reactions of the patient treated with HBOT was the oxygen toxic effect on the brain tissue. However, analyzing the circumstances of the seizure termination: phase of decompression at the pressure 2ATA and lack of oxygen disconnection response, it cannot be excluded other causes of this complication.

  4. Systematic review of hyperbaric oxygen therapy for the treatment of radiation-induced skin necrosis.

    Science.gov (United States)

    Borab, Zachary; Mirmanesh, Michael D; Gantz, Madeleine; Cusano, Alessandro; Pu, Lee L Q

    2017-04-01

    Every year, 1.2 million cancer patients receive radiation therapy in the United States. Late radiation tissue injury occurs in an estimated 5-15% of these patients. Tissue injury can include skin necrosis, which can lead to chronic nonhealing wounds. Despite many treatments available to help heal skin necrosis such as hyperbaric oxygen therapy, no clinical guidelines exist and evidence is lacking. The purpose of this review is to identify and comprehensively summarize studies published to date to evaluate the effectiveness of hyperbaric oxygen therapy for the treatment of radiation-induced skin necrosis. Adhering to PRISMA guidelines, a systematic review of currently published articles was performed, evaluating the use of hyperbaric oxygen to treat skin necrosis. Eight articles were identified, including one observational cohort, five case series, and two case reports. The articles describe changes in symptoms and alteration in wound healing of radiation-induced skin necrosis after treatment with hyperbaric oxygen therapy. Hyperbaric oxygen therapy is a safe intervention with promising outcomes; however, additional evidence is needed to endorse its application as a relevant therapy in the treatment of radiation-induced skin necrosis.

  5. Hyperbaric oxygen therapy combined with Schwann cell transplantation promotes spinal cord injury recovery

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    Chuan-gang Peng

    2015-01-01

    Full Text Available Schwann cell transplantation and hyperbaric oxygen therapy each promote recovery from spinal cord injury, but it remains unclear whether their combination improves therapeutic results more than monotherapy. To investigate this, we used Schwann cell transplantation via the tail vein, hyperbaric oxygen therapy, or their combination, in rat models of spinal cord contusion injury. The combined treatment was more effective in improving hindlimb motor function than either treatment alone; injured spinal tissue showed a greater number of neurite-like structures in the injured spinal tissue, somatosensory and motor evoked potential latencies were notably shorter, and their amplitudes greater, after combination therapy than after monotherapy. These findings indicate that Schwann cell transplantation combined with hyperbaric oxygen therapy is more effective than either treatment alone in promoting the recovery of spinal cord in rats after injury.

  6. Case Report: Improved Homonymous Hemianopia with Hyperbaric Oxygen Therapy

    Science.gov (United States)

    2017-06-29

    6, Q5 eNd . • PREVlOCl5eomONSARE OESct..E59 MD I FO 3039. 20160628 F~...a1bed 59 ••100 4 1Ca RSSEA.~CH 2. FRCfo!: (!luI JASON A. KEI.. •.•Y •.•..t 5... noted to have large areas of ischemic change in the occipital and parietal lobes bilaterally. Following discharge a complete left homonymous...hemianopia was noted and approximately 5 months after initial insult hyperbaric oxygen treatments were initiated. Materials and Methods The patient underwent

  7. Treatment of femoral head osteonecrosis with core decompression and subsequent hyperbaric oxygen therapy

    Directory of Open Access Journals (Sweden)

    Alper Deveci

    2013-06-01

    Full Text Available Aim. Regardless the etiologic factor, femoral head avascular necrosis is a process that occurs with femoral head local blood supply deficiency. The purpose of our study was to evaluate the clinical and radiologic outcomes in patients diagnozed with grade 1 and 2 avascular necrosis of the femoral head who were treated with a combination of core decompression and hyperbaric oxygen therapy. Method. In our study we have evaluated 21 hips of 16 patients retrospectively, which we have treated with a combination of core decompression and hyperbaric oxygen therapy. We performed clinical and radiological evaluation to the patients. Result. VAS and Harris hip scores showed improvement in all of our patients except in short term results. Conclusion. Core decompression and subsequent hyperbaric oxygen therapy are accomplishing each other because of their synergistic effects.

  8. Hyperbaric oxygen therapy for the treatment of traumatic brain injury: a meta-analysis.

    Science.gov (United States)

    Wang, Fei; Wang, Yong; Sun, Tao; Yu, Hua-Lin

    2016-05-01

    Compelling evidence suggests the advantage of hyperbaric oxygen therapy (HBOT) in traumatic brain injury. The present meta-analysis evaluated the outcomes of HBOT in patients with traumatic brain injury (TBI). Prospective studies comparing hyperbaric oxygen therapy vs. control in patients with mild (GCS 13-15) to severe (GCS 3-8) TBI were hand-searched from medical databases using the terms "hyperbaric oxygen therapy, traumatic brain injury, and post-concussion syndrome". Glasgow coma scale (GCS) was the primary outcome, while Glasgow outcome score (GOS), overall mortality, and changes in post-traumatic stress disorder (PTSD) score, constituted the secondary outcomes. The results of eight studies (average age of patients, 23-41 years) reveal a higher post-treatment GCS score in the HBOT group (pooled difference in means = 3.13, 95 % CI 2.34-3.92, P traumatic brain injury.

  9. Usefulness of high doses of glucocorticoids and hyperbaric oxygen therapy in sudden sensorineural hearing loss treatment.

    Science.gov (United States)

    Narozny, Waldemar; Sicko, Zdzislaw; Przewozny, Tomasz; Stankiewicz, Czeslaw; Kot, Jacek; Kuczkowski, Jerzy

    2004-11-01

    We investigated the effect of pharmacologic (steroids, vasodilators, vitamins, and Betaserc) and hyperbaric oxygen therapy on patients with sudden sensorineural hearing loss. The pharmacologic arm of the study consisted of 52 patients with defined sudden sensorineural hearing loss treated simultaneously in the ENT Department and National Center for Hyperbaric Medicine of the Medical University of Gdansk, Poland, from 1997 to 2000 (Group A). The hyperbaric oxygen therapy consisted of exposure to 100% oxygen at a pressure of 250 kPa for a total of 60 minutes in a multiplace hyperbaric chamber. The control group included 81 patients with defined sudden sensorineural hearing loss treated in the ENT Department, Medical University of Gdansk, from 1980 to 1996 (Group B). Both groups were comparable regarding the age of the patients, season of hearing loss occurrence, tinnitus and vestibular symptom frequency, delay before therapy, and average threshold loss before the start of treatment. The treatment results (hearing gain) were estimated using pure-tone audiometry. We retrospectively analyzed the audiograms of all patients. Patients from Group A (blood flow-promoting drugs, glucocorticoids in high doses, betahistine, and hyperbaric oxygen therapy) showed significantly better recovery of hearing levels compared with those from Group B (blood flow-promoting drugs and glucocorticoids in low doses) at seven frequencies (500, 1,000, 2,000, 3,000, 4,000, 6,000, and 8,000 Hz) (p < 0.05) and four groups of frequencies (pure-tone average, high-tone average, pure middle-tone average, and overall average) (p < 0.05). Percentage hearing gain in all investigated frequencies was also better in Group A versus Group B, and the differences were statistically significant (p < 0.05). We conclude that hyperbaric oxygen therapy with high doses of glucocorticoids improves the results of conventional sudden sensorineural hearing loss treatment and should be recommended. In addition, the best

  10. Prognostic effect of hyperbaric oxygen therapy starting time for sudden sensorineural hearing loss.

    Science.gov (United States)

    Yıldırım, Erol; Murat Özcan, K; Palalı, Mehmet; Cetin, Mehmet Ali; Ensari, Serdar; Dere, Hüseyin

    2015-01-01

    Sudden sensorineural hearing loss is one of the otological emergencies whose pathogenesis is uncertain and associated with total or partial loss of hearing function. The aim of this study was to investigate whether the hyperbaric oxygen therapy starting time affects the management of sudden sensorineural hearing loss. Fifty-nine patients with sudden sensorineural hearing loss admitted to our clinic between 2008 and 2012 were retrospectively included in this study. All patients received hyperbaric oxygen therapy. In addition, each patient received intravenous piracetam and 37 patients received steroid therapy. Hyperbaric oxygen therapy was initiated between 1 and 7 days with 20 patients determined as Group A, between 8 and 14 days with 25 patients determined as Group B and between 15 and 28 days with 14 patients determined as Group C. Hearing gains of these three groups were statistically evaluated. Each of them showed statistically significant improvement. Lowest hearing gain was observed in Group C and the gain of this group was statistically less than the other two groups. There was no significant difference between the hearing gains of the Group A and Group B. Starting hyperbaric oxygen therapy in patients with sudden sensorineural hearing loss within the first 14 days has positive effect on the prognosis of the disease.

  11. An Eye Popping Case of Orbital Necrotizing Fasciitis Treated with Antibiotics, Surgery, and Hyperbaric Oxygen Therapy.

    Science.gov (United States)

    Singam, Narayanasarma V; Rusia, Deepam; Prakash, Rajan

    2017-04-01

    BACKGROUND Necrotizing fasciitis (NF) of the orbit is a rare and deadly condition that requires prompt surgical and medical management to decrease morbidity and mortality.  CASE REPORT Here we present an interesting case of an individual who developed fulminant NF of the left orbit requiring emergent surgical intervention, antibiotics, and subsequent hyperbaric oxygen therapy in an attempt to save the eye.  CONCLUSIONS With an early and aggressive multifaceted approach using antibiotics, surgery, and hyperbaric oxygen it may be possible to preserve eye structure and function. Without treatment NF is a rapidly progressive condition and can result in significant morbidity.

  12. Hyperbaric oxygen therapy may overcome nitric oxide blockage during cyanide intoxication

    DEFF Research Database (Denmark)

    Polzik, Peter; Hansen, Marco Bo; Olsen, Niels Vidiendal

    2017-01-01

    PURPOSE: To determine the effects of a blockade of nitric oxide (NO) synthesis on hyperbaric oxygen (HBO₂) therapy during cyanide (CN) intoxication. METHODS: 39 anesthetized female Sprague-Dawley rats were exposed to CN intoxication (5.4 mg/kg intra-arterially) with or without previous nitric oxide...

  13. Hyperbaric oxygen therapy: solution for difficult to heal acute wounds? Systematic review

    NARCIS (Netherlands)

    A.M. Eskes; D.T. Ubbink; M.J. Lubbers; C. Lucas; H. Vermeulen

    2011-01-01

    Hyperbaric oxygen therapy (HBOT) is used to treat various wound types. However, the possible beneficial and harmful effects of HBOT for acute wounds are unclear. We undertook a systematic review to evaluate the effectiveness of HBOT compared to other interventions on wound healing and adverse effect

  14. [The future of hyperbaric oxygen therapy: added value in the treatment of late radiation injury?

    NARCIS (Netherlands)

    Geel, A.N. van; Poortmans, P.; Koppert, L.B.

    2015-01-01

    There is some evidence for the benefit of hyperbaric oxygen therapy in late radiation tissue injury (LRTI) affecting the head, neck and lower bowel, but there is little evidence for or against the benefit in other tissues (e.g. the breast) affected by LRTI. There is a need for large prospective tria

  15. Hyperbaric oxygen therapy for the prevention of arterial gas embolism in food grade hydrogen peroxide ingestion.

    Science.gov (United States)

    Hendriksen, Stephen M; Menth, Nicholas L; Westgard, Bjorn C; Cole, Jon B; Walter, Joseph W; Masters, Thomas C; Logue, Christopher J

    2016-12-14

    Food grade hydrogen peroxide ingestion is a relatively rare presentation to the emergency department. There are no defined guidelines at this time regarding the treatment of such exposures, and providers may not be familiar with the potential complications associated with high concentration hydrogen peroxide ingestions. In this case series, we describe four patients who consumed 35% hydrogen peroxide, presented to the emergency department, and were treated with hyperbaric oxygen therapy. Two of the four patients were critically ill requiring intubation. All four patients had evidence on CT or ultrasound of venous gas emboli and intubated patients were treated as if they had an arterial gas embolism since an exam could not be followed. After hyperbaric oxygen therapy each patient was discharged from the hospital neurologically intact with no other associated organ injuries related to vascular gas emboli. Hyperbaric oxygen therapy is an effective treatment for patients with vascular gas emboli after high concentration hydrogen peroxide ingestion. It is the treatment of choice for any impending, suspected, or diagnosed arterial gas embolism. Further research is needed to determine which patients with portal venous gas emboli should be treated with hyperbaric oxygen therapy.

  16. Successful treatment of acute sensorineural hearing loss with hyperbaric oxygen therapy

    Institute of Scientific and Technical Information of China (English)

    Murat Salihoglu; Ali Memis; Mesut Mutluoglu; Gunalp Uzun; Hakan Ay

    2016-01-01

    Sudden sensorineural hearing loss (SSNHL) is an important acute clinical condition in children. A specific treatment is still missing. Hyperbaric oxygen (HBO) therapy is one of the recommended treatments for SSNHL in adults. Our knowledge on the use of HBO therapy in children for SSNHL is limited. Herein, we report the successful use of HBO therapy in the management of SSNHL in a 14-year-old child.

  17. Successful treatment of acute sensorineural hearing loss with hyperbaric oxygen therapy

    Directory of Open Access Journals (Sweden)

    Murat Salihoglu

    2016-07-01

    Full Text Available Sudden sensorineural hearing loss (SSNHL is an important acute clinical condition in children. A specific treatment is still missing. Hyperbaric oxygen (HBO therapy is one of the recommended treatments for SSNHL in adults. Our knowledge on the use of HBO therapy in children for SSNHL is limited. Herein, we report the successful use of HBO therapy in the management of SSNHL in a 14-year-old child.

  18. The American College of Hyperbaric Medicine consensus statement on physician credentialing for hyperbaric oxygen therapy.

    Science.gov (United States)

    Serena, Thomas E; Gelly, Helen; Bohn, Gregory A; Niezgoda, Jeffrey A

    2014-08-01

    The American College of Hyperbaric Medicine provides this document for hospital credentialing committees as national standards for credentialing hyperbaric physicians. These recommendations represent the consensus opinion of expert leaders in the field of hyperbaric medicine. The principles set forth in this document are intended to serve as a guideline to assist healthcare organizations. This document applies to both hospital-based and nonhospital-affiliated centers.

  19. Efficacy of hyperbaric oxygen therapy in patients with radiation-induced rectal ulcers: A report of five cases.

    Science.gov (United States)

    Yoshimizu, Shoichi; Chino, Akiko; Miyamoto, Yuji; Tagao, Fuyuki; Iwasaki, Susumu; Ide, Daisuke; Tamegai, Yoshiro; Igarashi, Masahiro; Saito, Shoichi; Fujisaki, Junko

    2017-03-28

    For decades, hyperbaric oxygen therapy has been considered a treatment option in patients with chronic radiation-induced proctitis after pelvic radiation therapy. Refractory cases of chronic radiation-induced proctitis include ulceration, stenosis, and intestinal fistulas with perforation. Appropriate treatment needs to be administered. In this study, we assessed the efficacy of hyperbaric oxygen therapy in five patients with radiation-induced rectal ulcers. Significant improvement and complete ulcer resolution was observed in all treated patients; no side effects were reported. Hyperbaric oxygen therapy has a low toxicity profile and appears to be highly effective in patients with radiation-induced rectal ulcers. However, hyperbaric oxygen therapy alone failed to improve telangiectasia and easy bleeding in four of five patients; these patients were further treated with argon plasma coagulation. Although hyperbaric oxygen therapy may be effective in healing patients with ulcers, it seems inadequate in cases that easy bleeding. Altogether, these data suggest that combination therapy with hyperbaric oxygen therapy and argon plasma coagulation may be an effective and safe treatment strategy in patients with radiation-induced rectal ulcers. This article is protected by copyright. All rights reserved.

  20. Non-convulsive status epilepticus in a patient with carbon-monoxide poisoning treated with hyperbaric oxygen therapy.

    Science.gov (United States)

    Marziali, Simone; Di Giuliano, Francesca; Picchi, Eliseo; Natoli, Silvia; Leonardis, Carlo; Leonardis, Francesca; Garaci, Francesco; Floris, Roberto

    2016-12-01

    The presentation of carbon monoxide poisoning is non-specific and highly variable. Hyperbaric oxygen therapy is used for the treatment of this condition. Various reports show the occurrence of self-limiting seizures after carbon monoxide poisoning and as a consequence of hyperbaric oxygen therapy. Contrary to the seizures, status epilepticus has been rarely observed in these conditions. The exact pathophysiology underlying seizures and status epilepticus associated with carbon monoxide poisoning and hyperbaric oxygen therapy is not really clear, and some elements appear to be common to both conditions. We describe a case of non-convulsive status epilepticus in a patient with carbon monoxide poisoning treated with hyperbaric oxygen therapy. The mechanism, MRI findings and implications are discussed.

  1. Hyperbaric Oxygen Therapy for Sudden Sensorineural Hearing Loss after Failure from Oral and Intratympanic Corticosteroid

    Science.gov (United States)

    Poonsap, Pipat; Snidvongs, Kornkiat

    2012-01-01

    Systemic and intratympanic steroids are most widely used for treating idiopathic sudden sensorineural hearing loss. Other treatments include vasodilator, immunosuppressant and antiviral medication. However, only 61% of patients achieve full recovery, and controversies about the standard treatment still exist. In this case report, we present a patient with idiopathic sudden sensorineural hearing loss who failed to respond to systemic and intratympanic steroid treatments but subsequently recovered after undergoing hyperbaric oxygen therapy. PMID:22701158

  2. [Experience in the treatment of severe forms of sepsis by extracorporeal therapy and hyperbaric oxygenation].

    Science.gov (United States)

    Zhidkov, K P; Klechikov, V Z; Bogatyr', M N

    1997-01-01

    The results of multiple modality treatment of 81 patients with sepsis complicated by multiple organ failure are assessed. In 40 patients the traditional therapy of sepsis was supplemented with extracorporeal methods (hemoperfusion, autotransfusion of UV-exposed blood, and perfusion of xenospleen slices) and hyperbaric oxygenation (HBO) sessions. In the patients treated traditionally the mortality was 94%, whereas addition of extracorporeal treatment and HBO decreased this value to 40%. Hence, extracorporeal treatment and HBO are recommended for the treatment of sepsis.

  3. Hyperbaric oxygen therapy for sudden sensorineural hearing loss after failure from oral and intratympanic corticosteroid.

    Science.gov (United States)

    Imsuwansri, Thanarath; Poonsap, Pipat; Snidvongs, Kornkiat

    2012-04-01

    Systemic and intratympanic steroids are most widely used for treating idiopathic sudden sensorineural hearing loss. Other treatments include vasodilator, immunosuppressant and antiviral medication. However, only 61% of patients achieve full recovery, and controversies about the standard treatment still exist. In this case report, we present a patient with idiopathic sudden sensorineural hearing loss who failed to respond to systemic and intratympanic steroid treatments but subsequently recovered after undergoing hyperbaric oxygen therapy.

  4. Hyperbaric oxygen therapy for treatment of children with autism: a systematic review of randomized trials

    Directory of Open Access Journals (Sweden)

    Ghanizadeh Ahmad

    2012-05-01

    Full Text Available Abstract There is a controversy about the efficacy of hyperbaric oxygen (HBO therapy for the treatment of autism. This study systematically reviews the current evidences for treating of autism with HBO therapy. According to PRISMA guidelines for a systematic review, the databases of MEDLINE/Pubmed, Google Scholar, and Randomised Controlled Trials in Hyperbaric Medicine were electronically searched. In addition, medical subject heading terms and text words for hyperbaric oxygen therapy and autism were used. The main inclusion criteria were published studies which reported the original data from the trials conducted on the patients with autism and assessed outcomes with a valid and reliable instrument. A quality assessment was also conducted. The electronically search resulted in 18 title of publications. Two studies were randomized, double-blind, controlled-clinical trials. While some uncontrolled and controlled studies suggested that HBO therapy is effective for the treatment of autism, these promising effects are not replicated. Therefore, sham-controlled studies with rigorous methodology are required to be conducted in order to provide scientific evidence-based HBO therapy for autism treatment.

  5. The use of hyperbaric oxygen therapy and LED therapy in diabetic foot

    Science.gov (United States)

    Marques, Cristiane R. S.; Martin, Airton A.; Lima, Carlos J.; Conrado, Luis A. L.; Silveira, Fabricio L.; Carvalho, Marcos V.

    2004-07-01

    Chronic foot ulcers are common ailments presented in diabetes, which offer severe complications and are often unresponsive to therapy. In this work it was evaluated the effects of adjunctive Hyperbaric Oxygen Therapy (HBO) treatment and LEDtherapy irradiation on ulcer healing (HBO) in addition to conventional treatment. In ulcers of diabetic foot these treatments lead to a reduction in the probability of amputation up to almost four times compared with patients not receiving such co-adjutant treatment. The LEDtherapy irradiation was given concurrently using an energy density of 4J/cm2 for 5 min. During the experiment nine patients with diabetic foot ulcers were submitted for HBO sessions with 2,5 ATM for two hours. The experiment demonstrated the effectiveness of HBO + LEDtherapy treatment by favoring the ulcer healing through an increased fibroblastic response, collagen synthesis and neo-vascularization of the ischaemia, as well as increases in the leukocytic bactericidal activity.

  6. An Eye Popping Case of Orbital Necrotizing Fasciitis Treated with Antibiotics, Surgery, and Hyperbaric Oxygen Therapy

    Science.gov (United States)

    Singam, Narayanasarma V.; Rusia, Deepam; Prakash, Rajan

    2017-01-01

    Patient: Female, 60 Final Diagnosis: Necrotizing fasciitis of the eye Symptoms: Eye pain Medication: — Clinical Procedure: — Specialty: Infectious Diseases Objective: Unusual clinical course Background: Necrotizing fasciitis (NF) of the orbit is a rare and deadly condition that requires prompt surgical and medical management to decrease morbidity and mortality. Case Report: Here we present an interesting case of an individual who developed fulminant NF of the left orbit requiring emergent surgical intervention, antibiotics, and subsequent hyperbaric oxygen therapy in an attempt to save the eye. Conclusions: With an early and aggressive multifaceted approach using antibiotics, surgery, and hyperbaric oxygen it may be possible to preserve eye structure and function. Without treatment NF is a rapidly progressive condition and can result in significant morbidity. PMID:28364115

  7. Hyperbaric oxygen combined with drug therapy in the treatment of acute cerebral infarction clinical analysis

    Institute of Scientific and Technical Information of China (English)

    Wen-Cui Lin; Kang Lin; Jing Wang; Shuai Li

    2015-01-01

    Objective:To explore the effects of hyperbaric oxygen combined with edaravone, salviae miltiorrhizae and ligustrazine and sodium ozagrel in the treatment of acute cerebral infarction clinical analysis.Methods: A total of 200 cases of acute cerebral infraction patients were randomly divided into observation group and control group. The control group was treated with edaravone, salvia miltiorrhizae and ligustrazine and sodium ozagrel; on the basis of treatment in control group, the observation group was combined with hyperbaric oxygen therapy. The neurological deficit scores were observed before and after treatment in patients of two groups, meanwhile the activities of daily living (ADL) and clinical effects were compared.Results: The total effective rate in observation group (92%) was significantly higher than control group (79%), the differences were statistically significant; the score of ADL in observation group after treatment was obviously higher than control group [(79.91±5.16)vs (61.62±5.60)], and the differences were statistically significant. The neurological deficit scores after treatment were obviously lower than the control group [(9.55±4.13)vs (15.46±4.92)], the differences were statistically significant.Conclusion: Hyperbaric oxygen combined with edaravone, salvia miltiorrhizae and ligustrazine and sodium ozagrel in the treatment of acute cerebral infarction can improve the symptoms of microcirculation and neurologic impairment, and improve the patient s quality of life.

  8. Hyperbaric oxygen therapy as an effective adjunctive treatment for chronic Lyme disease.

    Science.gov (United States)

    Huang, Chien-Yu; Chen, Yen-Wen; Kao, Tseng-Hui; Kao, Hsin-Kuo; Lee, Yu-Chin; Cheng, Jui-Chun; Wang, Jia-Horng

    2014-05-01

    Lyme disease is the most commonly reported vector-borne illness in the United States, but it is relatively rare in Taiwan. Lyme disease can be treated with antibiotic agents, but approximately 20% of these patients experience persistent or intermittent subjective symptoms, so-called chronic Lyme disease (CLD). The mechanisms of CLD remain unclear and the symptoms related to CLD are difficult to manage. Hyperbaric oxygen therapy (HBOT) was applied in CLD therapy in the 1990s. However, reported information regarding the effectiveness of HBOT for CLD is still limited. Here, we present a patient with CLD who was successfully treated with HBOT.

  9. Hyperbaric oxygen therapy as an effective adjunctive treatment for chronic Lyme disease

    Directory of Open Access Journals (Sweden)

    Chien-Yu Huang

    2014-05-01

    Full Text Available Lyme disease is the most commonly reported vector-borne illness in the United States, but it is relatively rare in Taiwan. Lyme disease can be treated with antibiotic agents, but approximately 20% of these patients experience persistent or intermittent subjective symptoms, so-called chronic Lyme disease (CLD. The mechanisms of CLD remain unclear and the symptoms related to CLD are difficult to manage. Hyperbaric oxygen therapy (HBOT was applied in CLD therapy in the 1990s. However, reported information regarding the effectiveness of HBOT for CLD is still limited. Here, we present a patient with CLD who was successfully treated with HBOT.

  10. Nursing Experience of Hyperbaric Oxygen Therapy%高压氧治疗中的护理体会

    Institute of Scientific and Technical Information of China (English)

    薛颖

    2016-01-01

    In the higher than normal atmospheric pressure in the environment of inhalation of high concentration of oxygen therapy or surgery, hyperbaric oxygen therapy or hyperbaric oxygen therapy.Maintain the special equipment of hyperbaric oxygen therapy on the environment,said the hyperbaric oxygen chamber.At present,our country has established the hyperbaric oxygen treatment section in some hospitals,has developed to the medical field independent profession.%在高于正常大气压环境下吸入高浓度氧治疗或手术,称高压氧疗法或高压氧手术。维持高压氧治疗环境的特殊设备,称高压氧舱。目前我国在一些医院成立了高压氧治疗科,已发展为医学领域的一门独立的专业。

  11. Therapeutic effect of hyperbaric and normobaric oxygen therapy on experimental fetal growth restriction in rats

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    Ting WAN

    2011-10-01

    Full Text Available Objective To explore the therapeutic effect of hyperbaric and normobaric oxygen on experimental fetal growth restriction(FGR in rats.Methods Forty pregnant Sprague-Dawley rats were divided into five groups(8 each: control group(group N,did nothing to rats,sham operation group(group M,rats were only anesthetized on day 12 of gestation and did nothing else except that,FGR model group(group F,rats accepted partial ligation of both uterine arteries and veins on day 12 of gestation and no therapy after that,hyperbaric oxygen therapy group(group A,rats accepted hyperbaric oxygen treatment after the operation,normobaric hyperoxia therapy group(group B,rats accepted normobaric oxygen treatment after the operation.On day 21 of gestation,the fetuses and placentas in all groups were surgically taken out and weighted,and the incidence of FGR and mortality in the fetus,and pathological changes of placentas were analyzed.Results Newborn’s weight in group F,N,M,A and B respectively were 3.26±0.49g,4.57±0.37g,4.46±0.36g,4.11±0.37g and 4.08±0.32g,and the placenta weight were 0.40±0.05g,0.54±0.07g,0.53±0.08g,0.47±0.05g and 0.46±0.05g.Newborn’s weight and placenta in group F were significantly lower than that in group N and M(P 0.05.FGR rates in group N,M,F,A and B respectively were 1.33%,2.94%,83.10%,13.63% and 13.89%,and mortality rates were 1.33%,1.47%,11.27%,6.06% and 6.94%.The incidence of FGR and the mortality in group F were significantly higher than that in group N(P < 0.01,and in group A and B were significantly lower than that in group N(P < 0.01.Blood stasis and villous ischemia were found in placenta of FGR model rats.Placental microcirculation was significantly improved in treatment groups.Conclusion Both hyperbaric oxygen and normobaric oxygen have a similar and good therapeutic effect on experimental FGR in rats.

  12. A hyperbaric oxygen chamber for animal experimental purposes

    NARCIS (Netherlands)

    U.M. Djasim (Urville); L. Spiegelberg (Linda); E.B. Wolvius (Eppo); K.G.H. van der Wal (Karel)

    2012-01-01

    textabstractFacilities for hyperbaric oxygen therapy that are suitable for animal experimental research are scarce. In this paper, the authors introduce a hyperbaric oxygen chamber that was developed specifically for animal experimental purposes. The hyperbaric oxygen chamber was designed to meet a

  13. Refractory vasculitic ulcer of the toe in adolescent suffering from Systemic Lupus Erythematosus treated successfully with hyperbaric oxygen therapy

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    Mauro Angela

    2010-10-01

    Full Text Available Abstract Skin ulcers are a dangerous and uncommon complication of vasculitis. We describe the case of a teenager suffering from Systemic Lupus Erythematosus with digital ulcer resistant to conventional therapy, treated successfully with Hyperbaric Oxygen Therapy. The application of hyperbaric oxygen, which is used for the treatment of ischemic ulcers, is an effective and safe therapeutic option in patients with ischemic vasculitic ulcers in combination with immunosuppressive drugs. Further studies are needed to evaluate its role as primary therapy for this group of patients.

  14. Nonhealing Wounds Caused by Brown Spider Bites: Application of Hyperbaric Oxygen Therapy.

    Science.gov (United States)

    Hadanny, Amir; Fishlev, Gregory; Bechor, Yair; Meir, Oshra; Efrati, Shai

    2016-12-01

    Bites by Loxosceles spiders (also known as recluse spiders or brown spiders) can cause necrotic ulcerations of various sizes and dimensions. The current standard of care for brown spider bites includes analgesics, ice, compression, elevation, antihistamines, and surgical debridement. Hyperbaric oxygen therapy (HBOT) in the treatment of brown spider bites has been administered in the early stage of ulceration, or 2 to 6 days after the bite. Unfortunately, the diagnosis of spider bite-related ulcers is often delayed and weeks or months may elapse before HBOT is considered. To evaluate the effect of HBOT on nonhealing wounds caused by brown spider bites in the late, chronic, nonhealing stage. Analysis of 3 patients with brown spider-bite healing wounds treated at The Sagol Center for Hyperbaric Medicine and Research in Israel. Patients presented 2 to 3 months after failure of other therapies including topical dressings, antibiotics, and corticosteroids. All patients were treated with daily 2 ATA (atmospheres absolute) with 100% oxygen HBOT sessions. All 3 patients were previously healthy without any chronic disease. Their ages were 30, 42, and 73 years. They were treated once daily for 13, 17, and 31 sessions, respectively. The wounds of all 3 patients healed, and there was no need for additional surgical intervention. There were no significant adverse events in any of the patients. Microvascular injury related to brown spider bites may culminate in ischemic nonhealing wounds even in a relatively young, healthy population. Hyperbaric oxygen therapy should be considered as a valuable therapeutic tool even months after the bite.

  15. Intratympanic steroid injection and hyperbaric oxygen therapy for the treatment of refractory sudden hearing loss.

    Science.gov (United States)

    Gülüstan, Filiz; Yazıcı, Zahide Mine; Alakhras, Wesam M E; Erdur, Omer; Acipayam, Harun; Kufeciler, Levent; Kayhan, Fatma Tulin

    2016-11-22

    Controversy surrounds the use of salvage therapies to treat sudden sensorineural hearing loss (SSNHL), with no consensus on recommendations. While several studies have demonstrated the effectiveness of intratympanic administration of steroids (ITS) and hyperbaric oxygen (HBO) treatment, few have compared the efficacy of ITS and HBO therapy in patients with refractory SSNHL. We evaluated the efficiency of ITS and HBO therapy in patients with refractory SSNHL. Patients who did not adequately benefit from systemic treatment were evaluated retrospectively. Refractory patients were defined as those who gained less than 20dB in hearing after initial treatment. All refractory patients were informed about salvage therapy options: ITS or HBO therapy, the advantages and disadvantages of which were explained briefly. ITS involved 4mg/mL dexamethasone administered through a 25 gauge needle. Patients underwent HBO therapy in a hyperbaric chamber where they breathed 100% oxygen for 120min at 2.5 atmospheric pressure. The hearing levels of both groups were evaluated before the salvage therapy and at 3 months after treatment. Improvements in hearing were evaluated according to the Furahashi criteria. We also compared the two therapies in terms of speech discrimination scores (SDSs) and the recovery of all frequencies. The salvage therapies generated similar results. Changes in pure tone averages and SDSs were similar for ITS and HBO therapy (p=0.364 and p=0.113). Comparison of SDSs and hearing thresholds at all frequencies showed similar levels of improvement. ITS and HBO therapy produced similar improvements in SSNHL patients, but the sample size was too small to draw definitive conclusions. Further randomized controlled studies are needed to identify the best therapy for patients with refractory sudden hearing loss. Copyright © 2016 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved.

  16. Hyperbaric oxygen therapy after Bothrops lanceolatus snake bites in Martinique: a brief report.

    Science.gov (United States)

    Hochedez, P; Thomas, L; Mehdaoui, H

    2010-01-01

    Every year 10 to 20 cases of snake bites are reported on the Caribbean island of Martinique. The only snake involved, Bothrops lanceolatus, is endemic on the island, and its bite may lead to systemic multifocal thrombotic complications in the'absence of the monospecific antivenom. Between January 1988 and January 2009, more than 250 snake bites have been reported, and five patients were treated with hyperbaric oxygen (HBO2) therapy for local complications. The patients were male, bitten on the leg or the hand, and presented with severe complications such as necrotizing soft tissue infections, compartment syndrome or abscesses despite prompt wound care and administration of antivenomous serum. Outcomes were favorable for these five patients, except for one who was left with a functional defect of the hand. Although snake bites are not part of the currently recommended indications for HBO2 therapy, local complications, namely compartment syndrome, necrotizing soft tissue infections and enhancement of healing in selected problem wounds, are approved uses of HBO2 therapy as defined by the Hyperbaric Oxygen Therapy Committee and would benefit from prospective studies.

  17. Effect of hyperbaric oxygen therapy on whole blood cyanide concentrations in carbon monoxide intoxicated patients from fire accidents

    DEFF Research Database (Denmark)

    Lawson-Smith, Pia; Jansen, Erik C; Hilsted, Linda

    2010-01-01

    and possibly death. While several reports support the use of hyperbaric oxygen therapy (HBO) for the treatment of severe CO poisoning, limited data exist on the effect of HBO during CN poisoning. HBO increases the elimination rate of CO haemoglobin in proportion to the increased oxygen partial pressure...

  18. Controlled Evaluation of the Effects of Hyperbaric Oxygen Therapy on the Behavior of 16 Children with Autism Spectrum Disorders

    Science.gov (United States)

    Jepson, Bryan; Granpeesheh, Doreen; Tarbox, Jonathan; Olive, Melissa L.; Stott, Carol; Braud, Scott; Yoo, J. Helen; Wakefield, Andrew; Allen, Michael S.

    2011-01-01

    Hyperbaric oxygen therapy (HBOT) has been used to treat individuals with autism. However, few studies of its effectiveness have been completed. The current study examined the effects of 40 HBOT sessions at 24% oxygen at 1.3 ATA on 11 topographies of directly observed behavior. Five replications of multiple baselines were completed across a total…

  19. Hyperbaric oxygen therapy in the surgical approach to an irradiated patient

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    Antônio Figueiredo Caubi

    2008-01-01

    Full Text Available Cancer is the terminology applied to a set of more than one hundred diseases that have disorderly cell growth in common. The treatmentof cancer can be performed by surgery, radiotherapy, chemotherapy, or bone marrow transplant. In the region of the head and neck,radiotherapy results in a series of complications in the patient, such as hypovascularization of the irradiated tissues, with reduced demand of oxygen and cells, and there is risk of the occurrence of osteoradionecrosis after tooth extraction, leading to the need for a differentiated approach to these patients. Of the therapeutic conduct adopted in the approach to irradiated patients, hyperbaric oxygen therapy is a well established resource, as the therapeutic principle of this modality enables the restoration of an adequate process of tissue repair. In this study, a clinical case is related, of the use of hyperbaric oxygen therapy as an adjuvant procedure, before and after multiple tooth extractions, in a patient irradiated in the head and neck region, obtaining success with cicatricial repair without complications.

  20. Adjunctive Hyperbaric Oxygen Therapy or Alone Antibiotherapy? Methicillin Resistant Staphylococcus aureus Mediastinitis in a Rat Model

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    Tolga Kurt

    2015-10-01

    Full Text Available ABSTRACT OBJECTIVE: In the post-sternotomy mediastinitis patients, Staphylococcus aureus is the pathogenic microorganism encountered most often. In our study, we aimed to determine the efficacy of antibiotic treatment with vancomycin and tigecycline, alone or in combination with hyperbaric oxygen treatment, on bacterial elimination in experimental S. aureus mediastinitis. METHODS: Forty-nine adult female Wistar rats were used. They were randomly divided into seven groups, as follows: non-contaminated, contaminated control, vancomycin, tigecycline, hyperbaric oxygen, hyperbaric oxygen + vancomycin and hyperbaric oxygen + tigecycline. The vancomycin rat group received 10 mg/kg/day of vancomycin twice a day through intramuscular injection. The tigecycline group rats received 7 mg/kg/day of tigecycline twice a day through intraperitoneal injection. The hyperbaric oxygen group underwent 90 min sessions of 100% oxygen at 2.5 atm pressure. Treatment continued for 7 days. Twelve hours after the end of treatment, tissue samples were obtained from the upper part of the sternum for bacterial count assessment. RESULTS: When the quantitative bacterial counts of the untreated contaminated group were compared with those of the treated groups, a significant decrease was observed. However, comparing the antibiotic groups with the same antibiotic combined with hyperbaric oxygen, there was a significant reduction in microorganisms identified (P<0.05. Comparing hyperbaric oxygen used alone with the vancomycin and tigecycline groups, it was seen that the effect was not significant (P<0.05. CONCLUSION: We believe that the combination of hyperbaric oxygen with antibiotics had a significant effect on mediastinitis resulting from methicillin-resistant Staphylococcus aureus. Methicillin-resistant Staphylococcus aureus mediastinitis can be treated without requiring a multidrug combination, thereby reducing the medication dose and concomitantly decreasing the side effects.

  1. The effects of hyperbaric oxygen therapy upon ototoxic injuries produced by amikacin in guinea pigs.

    Science.gov (United States)

    Amora, Luciana de Albuquerque Salviano; Murashima, Adriana de Andrade Batista; Rossato, Maria; Moreira, Márcia Bento; Hyppolito, Miguel Ângelo; Fagundes, Djalma José

    2013-01-01

    Hyperbaric oxygen therapy (HBOT) has enhanced the prevention and treatment of auditory ailments such as ototoxicity. To study the effects of HBOT upon ototoxic injuries produced by amikacin. This experimental study included 12 albino guinea pigs, whose auditory function was assessed through distortion product otoacoustic emissions (DPOAEs) and brainstem auditory evoked potentials (BAEPs) before and after the administration of amikacin (600 mg/kg/day) and HBOT sessions (2 ATA, 60 minutes). Morphological features were analyzed through scanning electron microscopy. Subjects were divided into four groups, as follows: group 1 - saline solution + HBOT; group 2 - amikacin for 8 days; group 3 - amikacin + seven days of rest; and group 4 - amikacin + HBOT. Group 1 subjects had preserved function and morphology throughout the experiment; Group 2 subjects had statistically significant levels of hair cell injury and functional impairment; Subjects on groups 3 and 4 had statistically significant functional and morphological impairment after the administration of amikacin, which were still present after the proposed procedures had been carried out. Hyperbaric oxygen therapy did not change the cochlear hair cell morphology or the electro-physiological thresholds of the guinea pigs given amikacin.

  2. A Multidisciplinary Approach with Hyperbaric Oxygen Therapy Improve Outcome in Snake Bite Injuries.

    Science.gov (United States)

    Korambayil, Pradeoth Mukundan; Ambookan, Prashanth Varkey; Abraham, Siju Varghese; Ambalakat, Ajay

    2015-01-01

    Snakebite injuries are common in tropical India among those who are involved in outdoor activities. These injuries results in cellulitis, gangrene at the bite area, bleeding manifestations, compartment syndrome, regional lymphadenopathy, septicemia, hypotension, and disseminated intravascular coagulation (DIC) resulting in significant morbidity and mortality. The purpose of this study is to share our experience of multidisciplinary approach in the management of snakebite injuries of the extremities with various treatment modalities including hyperbaric oxygen (HBO) therapy, surgical debridement, and soft tissue reconstruction to provide an effective treatment for snake bite injuries. The study was conducted in the Department of Plastic Surgery, during the period October 2012-December 2014, wherein all the patients who were admitted with snakebite injuries were enrolled and the patients treated in plastic surgery department were included into the study. Out of total 766 patients, there were 323 patients treated with anti snake venom (ASV) and 29 died among the treated patients; 205 patients belonged to pediatric age group. Out of 112 patients referred to Department of Plastic Surgery, 50 cases presented with cellulitis, 24 patients with compartment syndrome, and 38 patients were referred for the management of soft tissue cover over the extremities. Among 112 patients, 77 involved the lower extremity and 35 the upper extremity. Multidisciplinary approach including hyperbaric oxygen (HBO) therapy improves outcome in the management of snakebite injuries of the extremities.

  3. Hyperbaric oxygen therapy attenuates central sensitization induced by a thermal injury in humans

    DEFF Research Database (Denmark)

    Rasmussen, V M; Borgen, A E; Jansen, E C

    2015-01-01

    BACKGROUND: Hyperbaric oxygen (HBO2 ) treatment has in animal experiments demonstrated antinociceptive effects. It was hypothesized that these effects would attenuate secondary hyperalgesia areas (SHAs), an expression of central sensitization, after a first-degree thermal injury in humans. METHODS......, compared with control. These new and original findings in humans corroborate animal experimental data. The thermal injury model may give impetus to future human neurophysiological studies exploring the central effects of hyperbaric oxygen treatment....

  4. Histological changes during orthodontic tooth movement due to hyperbaric oxygen therapy

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    Arya Brahmanta

    2017-02-01

    Full Text Available Background: Mechanical force of orthodontics causes changes in periodontal ligament vascularization and blood flow, resulting in biochemical and cellular changes as well as changes in the contour of the alveolar bone and in the thickness of the periodontal ligaments. Hyperbaric oxygen (HBO therapy is one of many solutions stimulating the growth of new blood vessels and increasing tissue oxygenation. Thus, HBO plays a role in recovery of periodontal ligament and osteoblasts. Purpose: This study aimed to determine the effects of HBO therapy for seven days on periodontal ligament size and osteoblast number in the tension site during bone remodeling in tooth movement. Method: The study was true experimental laboratories with completely randomized control group post test only design. Twenty-four males guinea pigs were randomly divided into three groups. K0 was the control group without any treatment, K1 was the group given a mechanical orthodontic pressure, and K2 was the group treated with the addition of hyperbaric oxygen therapy. The maxillary incisors were moved distally by elastic separator. After HBO therapy on day 7, all of the groups were sacrificed, and then periodontal ligament size and osteoblast number were analyzed by one-way Anova and LSD statistical tests. Result: The results showed significant differences in the size of the periodontal ligament and the number of osteoblasts in the tension site among the groups (p<0.05. Conclusion: HBO therapy at 2.4 ATA for 7 days is effective in recovery of periodontal ligament and increased osteoblast number during bone remodeling in tension area of orthodontic tooth movement.

  5. Healing of spongiosus-cutaneous fistula with hyperbaric Oxygen Therapy (HBOT): a case report.

    Science.gov (United States)

    Della Camera, Pier A; Cito, Gianmartin; Morselli, Simone; Sessa, Francesco; Facchiano, Davide; Cocci, Andrea; Gacci, Mauro; Serni, Sergio; Carini, Marco; Natali, Alessandro

    2017-05-10

    We present a case of a spongiosus-cutaneous fistula in a 39-year-old man with recurrent episodes of cutaneous abscess in dorsal middle third penis (5 × 3 cm) treated with Hyperbaric Oxygen Therapy (HBOT). After emptying nodular abscess, the patient was noncompliant for further surgery. Therefore, it was suggested the association between HBOT and antibiotic therapy. HBOT is carried out in a hyperbaric room, where the internal pressure is increased (compression phase) by entering compressed air up to 283.71 kPa in about 10 minutes. Every HBOT cycle lasted 24 days in which the patient had been taking Amoxicillin/Clavulanic Acid 875 mg/125 mg 3 tabs/day and Sulfamethoxazole/Trimethoprim 160 mg/800 mg 2 tabs/day for 2 weeks. At the end of the treatment, a penile magnetic resonance imaging and an ultrasonography were executed and they evidenced a complete remission of the lesion. In the subsequent 22 months, there was no recurrence. Our results suggest that HBOT is an effective treatment for chronic wounds, including a spongiosus-cutaneous fistula of unknown cause, when used in combination with conventional standard therapy or further interventions. At present time, the gold standard remains surgery; nevertheless, our experience with HBOT may stimulate its use in clinical trials.

  6. The effect of hyperbaric oxygen therapy on the nervous system. Systematic review

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    Kujawski Sławomir

    2015-12-01

    Full Text Available Hyperbaric oxygen therapy (HBOT is found among the interests of researchers who seek new methods of treatment of diseases of the nervous system. An increase of the partial pressure of oxygen in arterial blood within the appropriate range leads to numerous changes in the cells of the brain tissue. In this paper we analyse the results of selected articles describing HBOT used on pathologies of the nervous system such as stroke, autism, multiple sclerosis and cerebral palsy as well as in the course of research on animal models. The results are promising, although some studies struggled with numerous methodological problems and differences in the applied protocols, which resulted in conflicting results in individual interventions. In consequence, the need for further studies in randomised control trials and determination of the protocol by an international group of researchers dedicated to the use of HBOT was emphasised.

  7. Hyperbaric oxygen treatment in radiation reactions; Hyperbar oksygenbehandling ved straalereaksjoner

    Energy Technology Data Exchange (ETDEWEB)

    Aanderud, Leif; Thorsen, Einar; Bratteboe, Guttorm; Forland, Martha; Kristensen, Gunnar

    2000-07-01

    Background: A national hyperbaric centre was established in 1994 at Haukeland Hospital with responsibility of all hyperbaric oxygen (HBO) treatment in Norway. In hypoxic tissues with symptomatic radiation reactions, hyperbaric oxygen induces the formation of collagen and angiogenesis resulting in permanently improved local microcirculation. Material and method: 234 patients received elective HBO treatment at Haukeland Hospital in 12997 with total of 4048 treatments. All 47 patients treated for radiation reactions in the pelvic area in 1997 received a questionnaire 3-15 months after HBO therapy, 81% reported. Results: Rectal bleeding and haematuria were reported as much improved in 61% and 55% respectively, while bladder incontinence was much improved in 46%. Interpretation: this treatment modality may be an alternative in symptomatic radiation reactions at the urinary bladder and the bowel when conventional treatment has given unsatisfactory results.

  8. Safety and efficacy of hyperbaric oxygen therapy in chronic wound management: current evidence

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    Eggleton P

    2015-04-01

    Full Text Available Paul Eggleton,1 Alexandra J Bishop,2 Gary R Smerdon21Institute of Biomedical & Clinical Science, University of Exeter Medical School, Exeter, 2DDRC Healthcare, Plymouth, UKAbstract: The breathing of pure oxygen under pressure to treat tissue damage has been employed for almost 45 years and has been investigated in prospective, retrospective, and randomized controlled trials. The physiological effects of oxygen treatment on wound tissue are profound, and include activation of immune cells, changes in cytokine production, and modulation of inflammatory and bactericidal mediators. Hyperbaric oxygen influences the biochemistry of whole cells, altering cell proliferation, angiogenesis, clotting, and tissue regeneration. The precise effects of hyperbaric oxygen on individual cell types and tissues are only beginning to be revealed in both animal and human studies. Many independent studies using hyperbaric oxygen adjunctively with standard wound care have observed improved healing, in particular for diabetic foot ulcers, and can result in a significant reduction in major amputations. Side effects occur infrequently, but myopia, ear barotrauma, and rarely oxygen toxicity have been reported. As antibiotics become less available, and clinician time and complex dressings become more expensive, use of hyperbaric oxygen as a means of treating a variety of wound types may become an increasingly appropriate option for treatment.Keywords: clinical trials, foot ulceration, non-healing wounds, oxygen

  9. Hyperbaric oxygen therapy as salvage treatment for sudden sensorineural hearing loss: a prospective controlled study.

    Science.gov (United States)

    Pezzoli, M; Magnano, M; Maffi, L; Pezzoli, L; Marcato, P; Orione, M; Cupi, D; Bongioannini, G

    2015-07-01

    The most commonly used treatment for sensorineural sudden hearing loss (SSHL) in clinical practice is the administration of steroids; however, a favorable result is not always obtained. We studied 58 patients who failed to recover after primary treatment with IV steroids, 44 of these met our inclusion criteria (mean age 50.7, 27 males, range 30-74). We treated 23 patients (mean age 47.3, 16 males, age range 22-74) with hyperbaric oxygen therapy (HBO) (2.5 ATA for 60 min for 15 treatments), while 21 (mean age 54.5, 11 males, age range 22-71) patients refused to be treated and served as a non-randomized control group. Patients treated with HBO had a mean improvement of 15.6 dB (SD ± 15.3), with 1 of them completely healed, 5 with a good recovery, 10 with a fair recovery and 7 unchanged. Patients who were not treated had a spontaneous mean improvement of 5.0 dB (SD ± 11.4) with 3 patients with a good recovery, 1 patient with a fair recovery and 17 patients unchanged. Mean improvement was significantly better in patients treated with HBO compared to controls (p = 0.0133). Patients with worst hearing had the greater degree of improvement whether or not they were treated in the first 10 days after the onset of the hearing loss or between 11 and 30 days. In conclusion, hyperbaric oxygen therapy can lead to significant improvement of pure tone hearing thresholds in patients with SSHL who failed primary corticosteroid treatment and are within 4 weeks of the onset of deafness.

  10. Four-week histologic evaluation of grafted calvarial defects with adjunctive hyperbaric oxygen therapy in rats

    Science.gov (United States)

    2016-01-01

    Purpose The aim of this study was to characterize the healing in the grafted calvarial defects of rats after adjunctive hyperbaric oxygen therapy. Methods Twenty-eight male Sprague-Dawley rats (body weight, 250–300 g) were randomly divided into two treatment groups: with hyperbaric oxygen therapy (HBO; n=14) and without HBO (NHBO; n=14). Each group was further subdivided according to the bone substitute applied: biphasic calcium phosphate (BCP; n=7) and surface-modified BCP (mBCP; n=7). The mBCP comprised BCP coated with Escherichia-coli-derived recombinant human bone morphogenetic protein-2 (ErhBMP-2) and epigallocatechin-3-gallate (EGCG). Two symmetrical circular defects (6-mm diameter) were created in the right and left parietal bones of each animal. One defect was assigned as a control defect and received no bone substitute, while the other defect was filled with either BCP or mBCP. The animals were allowed to heal for 4 weeks, during which those in the HBO group underwent 5 sessions of HBO. At 4 weeks, the animals were sacrificed, and the defects were harvested for histologic and histomorphometric analysis. Results Well-maintained space was found in the grafted groups. Woven bone connected to and away from the defect margin was formed. More angiogenesis was found with HBO and EGCG/BMP-2 (Pbone formation with HBO or EGCG/BMP-2 was evident in histologic evaluation, but it did not reach statistical significance in histometric analysis. A synergic effect between HBO and EGCG/BMP-2 was not found. Conclusions Within the limitations of this study, the present findings indicate that adjunctive HBO and EGCG/BMP-2 could be beneficial for new bone formation in rat calvarial defects. PMID:27588214

  11. A hyperbaric oxygen chamber for animal experimental purposes.

    Science.gov (United States)

    Djasim, U M; Spiegelberg, L; Wolvius, E B; van der Wal, K G H

    2012-02-01

    Facilities for hyperbaric oxygen therapy that are suitable for animal experimental research are scarce. In this paper, the authors introduce a hyperbaric oxygen chamber that was developed specifically for animal experimental purposes. The hyperbaric oxygen chamber was designed to meet a number of criteria regarding safety and ease of use. The hyperbaric oxygen chamber conforms to 97/23/EC (Pressure Equipment Directive), Conformity Assessment Module G Product Group 1. It provides easy access, and can be run in manual mode, semi-automatic mode and full-automatic mode. Sensors for pressure level, oxygen level, temperature, humidity and carbon dioxide level allow full control. This state-of-the-art hyperbaric oxygen chamber for animal experimental purposes permits the investigation of the biological mechanisms through which hyperbaric oxygen therapy acts at a fundamental level.

  12. Hyperbaric oxygen and wound healing

    Directory of Open Access Journals (Sweden)

    Sourabh Bhutani

    2012-01-01

    Full Text Available Hyperbaric oxygen therapy (HBOT is the use of 100% oxygen at pressures greater than atmospheric pressure. Today several approved applications and indications exist for HBOT. HBOT has been successfully used as adjunctive therapy for wound healing. Non-healing wounds such as diabetic and vascular insufficiency ulcers have been one major area of study for hyperbaric physicians where use of HBOT as an adjunct has been approved for use by way of various studies and trials. HBOT is also indicated for infected wounds like clostridial myonecrosis, necrotising soft tissue infections, Fournier′s gangrene, as also for traumatic wounds, crush injury, compartment syndrome, compromised skin grafts and flaps and thermal burns. Another major area of application of HBOT is radiation-induced wounds, specifically osteoradionecrosis of mandible, radiation cystitis and radiation proctitis. With the increase in availability of chambers across the country, and with increasing number of studies proving the benefits of adjunctive use for various kinds of wounds and other indications, HBOT should be considered in these situations as an essential part of the overall management strategy for the treating surgeon.

  13. Hyperbaric oxygen therapy or hydroxycobalamin attenuates surges in brain interstitial lactate and glucose; and hyperbaric oxygen improves respiratory status in cyanide-intoxicated rats

    DEFF Research Database (Denmark)

    Lawson-Smith, P; Olsen, Niels Vidiendal; Hyldegaard, Ole

    2011-01-01

    Cyanide (CN) intoxication inhibits cellular oxidative metabolism and may result in brain damage. Hydroxycobalamin (OHCob) is one among other antidotes that may be used following intoxication with CN. Hyperbaric oxygen (HBO2) is recommended when supportive measures or antidotes fail. However...

  14. De novo cataract development following a standard course of hyperbaric oxygen therapy.

    Science.gov (United States)

    Gesell, L B; Trott, A

    2007-01-01

    A 49 y/o female under went 48 hyperbaric oxygen (HBO2) treatments at 2.5 ATA (atmospheres absolute) (253 kPa) for 90 minutes for chronic refractory osteomyelitis of the sacrum and recurrent failure of a sacral myocutaneous flap. Prior to HBO2 therapy, formal ophthalmic exams revealed myopia but no evidence of cataract formation. Eight weeks following the completion of HBO2 therapy, on repeat ophthalmic exam, the patient was discovered to have worsening myopia. Changes of the crystalline lens, consistent with nuclear cataract development, were identified in each eye. Other common causes of cataract formation including diabetes, corticosteroid use, and excessive exposure to ultraviolet light, were excluded. While transient visual changes are known to occur during HBO2 therapy, cataract formation has only rarely been reported and only after prolonged courses of treatment (150 or more treatments). This case identifies the need to further investigate the ocular effects of HBO2 therapy, especially with regard to cataract development and progression.

  15. Hyperbaric oxygen therapy in tinnitus with normal hearing in association with combined treatment.

    Science.gov (United States)

    Holy, Richard; Prazenica, Pavol; Stolarikova, Eva; Dosel, Petr; Fundova, Petra; Kovar, Daniel; Astl, Jaromir

    2016-01-01

    Tinnitus is a phantom perception of sound in the absence of overt acoustic stimulation. The focus of our attention is a combined therapy of tinnitus. In this prospective study (2013-2014) we evaluated the data of normal-hearing patients with tinnitus treated with various treatment modalities. In Group 1 we evaluated the data of 84 patients/124 ears after six weeks of treatment with betahistine dihydrochloride (72 mg). In Group 2, we evaluated the data of 36 patients/ 55 ears unimproved from Group 1 who were then treated for six weeks with hyperbaric oxygen (HBO₂) therapy combined with gingko biloba extract (120 mg). In Group 1, tinnitus disappeared in 9.7%, alleviated in 18.5% and improved overall in 28.2%. Average intensity of tinnitus before/after treatment was 37 decibels (dB)/33 dB. Tinnitus intensities after treatment are statistically significantly lower (p = 0.001) than the values before treatment. In Group 2 tinnitus disappeared in 5.4%, 36.4% achieved alleviation, and 41.8% showed overall improvement. The average intensity of tinnitus before/after treatment was 41dB/ 38dB. The values of tinnitus intensity after combined therapy are statistically significantly lower (p = 0.046). We have shown that both methods treatment of tinnitus are statistically significant. HBO₂therapy was recommended for the general public.

  16. Hyperbaric oxygen therapy in a true regenerative environment, the regenerating limb of the axolotl

    DEFF Research Database (Denmark)

    Hansen, Kasper; Lauridsen, Henrik; Pedersen, Michael

    2012-01-01

    , the data is only indicative. At present, 80 constitutive days of HBOT has been performed for HBOT1. HBOT2 animals were not able to tolerate hyperbaric gaseous oxygen, and were excluded after 3 HBO treatments. No indicative effect of HBOT on whole limb regeneration has yet been identified. Discussion...

  17. Hyperbaric oxygen therapy attenuates neuropathic hyperalgesia in rats and idiopathic trigeminal neuralgia in patients.

    Science.gov (United States)

    Gu, N; Niu, J-Y; Liu, W-T; Sun, Y-Y; Liu, S; Lv, Y; Dong, H-L; Song, X-J; Xiong, L-Z

    2012-09-01

    Neuropathic pain after nerve injury is severe and intractable, and current drug and non-drug therapies offer very limited pain relief. Hyperbaric oxygen (HBO 2) has been clinically used for protection of the nervous system after acute injury. We investigated whether HBO 2 treatment could prevent and/or attenuate neuropathic pain in animals and in patients. Mechanical allodynia and thermal hyperalgesia and neurochemical alterations of neuropathic pain were analysed in male, adult, Sprague-Dawley rats with sciatic nerve injury. Clinical trials were conducted in patients with idiopathic trigeminal neuralgia. Repetitive HBO 2 treatment [a combination of pressure at 3 atmosphere absolute (ATA) and pure oxygen] greatly inhibited behavioural signs of neuropathic pain manifested as thermal hyperalgesia and mechanical allodynia. Such an HBO 2 treatment also inhibited nerve injury-induced induction of c-Fos and activation of astrocytes and increased phosphorylation of NR2B receptor and the subsequent Ca 2+-dependent signals in rats. Neither high pressure (up to 3 ATA) nor pure oxygen alone resulted in analgesic effect. In clinical trials, one course of HBO 2 therapy (10 consecutive days) produced a rapid-onset, dose-dependent and long-lasting analgesic effects evidenced by the decreased doses of carbamazepine required for keeping patient pain at a minimum and decreased scores of visual analogue scales, which was used for patient's self-evaluation. These findings support that HBO 2 therapy is an effective approach for treating neuropathic pain in both animals and human beings and suggest that neural protection, anti-inflammation and inhibition of nerve injury-induced altered neural activity may contribute to the analgesic effect of HBO 2 therapy. © 2012 European Federation of International Association for the Study of Pain Chapters.

  18. MRI evaluation of aseptic osteonecrosis in children over the course of hyperbaric oxygen therapy

    Energy Technology Data Exchange (ETDEWEB)

    Scherer, A.; Engelbrecht, V.; May, P.; Moedder, U. [Duesseldorf Univ. (Germany). Inst. fuer Diagnostische Radiologie; Bernbeck, B.; Goebel, U. [Duesseldorf Univ. (Germany). Dept. of Pediatric Hematology and Oncology; Willers, R. [Duesseldorf Univ. (Germany). Inst. of Statistics

    2000-10-01

    Purpose: The study aimed at MRI evaluation of aseptic osteonecrosis (AON) in children over the course of hyperbaric oxygen (HBO) therapy. Material and methods: Retrospective analysis of 72 MRI studies in 20 children presenting with AON during chemotherapy. Two groups were differentiated: Gr. I (n=8) was treated exclusively with relief of weightbearing structures, Gr. II (n=12) was additionally treated with HBO therapy. The MRI examinations were evaluated by a point-score system (1-6 points) by two radiologists. Results: Gr. II initially showed more severe findings (average score: 3.4) in comparison to Gr. I (average score: 2.65). During the follow-up time period the average scores rose to 3.2 score-points in Gr. I and 4.1 points in Gr. II. No statistically significant difference was evident between the two groups in the course of AON. Conclusion: The majority of chemotherapy associated AON which initially present with advanced findings show a progression in MRI over their further course. HBO therapy in addition to the relief of affected weightbearing structures statistically shows no significant improvement in MRI morphology during the course of the treatment. (orig.)

  19. Treatment of Laryngeal Radionecrosis with Hyperbaric Oxygen Therapy: A Case Report

    Directory of Open Access Journals (Sweden)

    Ying-Che Hsu

    2005-02-01

    Full Text Available An 81-year-old male with early-stage laryngeal carcinoma had been treated with 60 Gy curative radiotherapy. He complained of a sore throat, foul odor in the mouth, progressive dyspnea, and fever 2 months after the completion of radiotherapy. Direct laryngoscopy revealed narrowing of the glottis with diffuse ulcerative necrotic tissue. Biopsies at multiple sites and pathology revealed intense coagulation necrosis with complete denudation of covering epithelium without any malignancy. Since laryngeal radionecrosis was suspected, the patient received hyperbaric oxygen (HBO therapy 40 times for 1 hour of 100% O2 at 2 atm absolute pressure. His clinical symptoms gradually improved and repeated endolaryngeal biopsies were undertaken near the end of HBO therapy and again 6 months later. The patient's larynx healed completely with diffuse fibrosis and no malignant cells were found on pathology. Radionecrosis must be differentiated from cancer recurrence following curative radiotherapy for early laryngeal cancer. HBO therapy could be a useful treatment adjunct for laryngeal radionecrosis.

  20. Factors influencing the outcome of idiopathic sudden sensorineural hearing loss treated with hyperbaric oxygen therapy.

    Science.gov (United States)

    Körpinar, Sefika; Alkan, Zeynep; Yiğit, Ozgür; Gör, Ayşe Pelin; Toklu, Akin Savaş; Cakir, Burak; Soyuyüce, Ozlem Gedik; Ozkul, Haluk

    2011-01-01

    Idiopathic sudden sensorineural hearing loss (ISSNHL) is an otologic emergency with an incidence of about 5-20 per 100,000 of the population per year. There is no universally accepted standard protocol for the treatment of patients with ISSNHL. Hyperbaric oxygen therapy (HBOT), was first reported to improve the outcome following acute inner ear disorders during the late 1960s by both French and German authors. The increase in perilymph oxygenation produced by HBOT provides logical basis for the use of this treatment modality in ISSNHL. We reviewed the records of 97 cases that received HBOT for SSNHL to identify the factors that may affect the treatment outcomes. The effects of age, gender, affected ear, status of the contralateral ear, symptoms associated with hearing loss, presence of a cardiovascular disease, dyslipidemia, history of diabetes mellitus, seasonal factor, smoking, degree of hearing loss, audiogram type, medical treatments provided prior to HBOT, onset time, and number of HBOT sessions were evaluated. The mean hearing gain in all cases after the HBOT was 29.5 dB. The gains were statistically significant in the following cases: early onset of HBOT (p = 0.016), higher number of HBOT sessions (p hearing loss (p = 0.011). The success rate was significantly lower in cases with high frequency-descending audiogram configuration (p hearing loss.

  1. Hyperbaric oxygen therapy to treat diabetes impaired wound healing in rats.

    Directory of Open Access Journals (Sweden)

    Bastiaan Tuk

    Full Text Available Wound healing in diabetes is frequently impaired and its treatment remains a challenge. Hyperbaric oxygen therapy (HBOT receives a wide attendance and is often used as a last resort treatment option, however, its effectiveness for many conditions is unproven. We tested the effect of HBOT on healing of diabetic ulcers in an animal experimental setting. Experimental diabetes was induced by intraperitoneal injection of streptozotocin. Four weeks after diabetes induction, rats were ulcerated by clamping a pair of magnet disks on the dorsal skin for 16 h. After magnet removal, the animals received HBOT, daily on weekdays, for 4 weeks. To examine the effect of HBOT on diabetes impaired wound healing, the degree of wound tissue perfusion, inflammation, angiogenesis, and tissue breaking strength were evaluated. HBOT effects on the degree of inflammation and number of blood vessels could not be observed. HBOT improved the tissue breaking strength of the wound, however, this did not reach statistical significance. Twenty hours after ending the HBOT, a significantly improved oxygen saturation of the hemoglobin at the venous end of the capillaries and the quantity of hemoglobin in the micro-blood vessels was measured.

  2. The ketogenic diet and hyperbaric oxygen therapy prolong survival in mice with systemic metastatic cancer.

    Directory of Open Access Journals (Sweden)

    Angela M Poff

    Full Text Available INTRODUCTION: Abnormal cancer metabolism creates a glycolytic-dependency which can be exploited by lowering glucose availability to the tumor. The ketogenic diet (KD is a low carbohydrate, high fat diet which decreases blood glucose and elevates blood ketones and has been shown to slow cancer progression in animals and humans. Abnormal tumor vasculature creates hypoxic pockets which promote cancer progression and further increase the glycolytic-dependency of cancers. Hyperbaric oxygen therapy (HBO₂T saturates tumors with oxygen, reversing the cancer promoting effects of tumor hypoxia. Since these non-toxic therapies exploit overlapping metabolic deficiencies of cancer, we tested their combined effects on cancer progression in a natural model of metastatic disease. METHODS: We used the firefly luciferase-tagged VM-M3 mouse model of metastatic cancer to compare tumor progression and survival in mice fed standard or KD ad libitum with or without HBO₂T (2.5 ATM absolute, 90 min, 3x/week. Tumor growth was monitored by in vivo bioluminescent imaging. RESULTS: KD alone significantly decreased blood glucose, slowed tumor growth, and increased mean survival time by 56.7% in mice with systemic metastatic cancer. While HBO₂T alone did not influence cancer progression, combining the KD with HBO₂T elicited a significant decrease in blood glucose, tumor growth rate, and 77.9% increase in mean survival time compared to controls. CONCLUSIONS: KD and HBO₂T produce significant anti-cancer effects when combined in a natural model of systemic metastatic cancer. Our evidence suggests that these therapies should be further investigated as potential non-toxic treatments or adjuvant therapies to standard care for patients with systemic metastatic disease.

  3. Potential utility of hyperbaric oxygen therapy and propolis in enhancing the leishmanicidal activity of glucantime

    Directory of Open Access Journals (Sweden)

    Diana Copi Ayres

    2011-12-01

    Full Text Available In this study we investigated the efficacy of hyperbaric oxygen (HBO therapy, alone or combined with the pentavalent antimonial glucantime on Leishmania amazonensis infection. In parallel, the effect of Brazilian red propolis gel (propain alone or combined with glucantime on L. amazonensis infection was evaluated. The inhibition of the infection in macrophages treated with glucantime in combination with HBO exposition was greater than that of macrophages treated with glucantime alone or HBO alone. The susceptible mouse strain BALB/c infected in the shaved rump with L. amazonensis treated with glucantime and exposed to HBO showed: time points in the course of the disease in which lesions were smaller than those of mice treated with glucantime alone and revascularization of the skin in the lesion site; interferon-gamma (IFN-g levels were not elevated in lymph node cells from these animals. Propain alone was not efficient against lesions, although less exudative lesions were observed in animals treated with propain alone or combined with glucantime. These results reveal the potential value of HBO and red propolis in combination with glucantime for treating cutaneous leishmaniasis and encourage further studies on the effect of more aggressive HBO, propolis and glucantime therapies on different mouse models of leishmaniasis.

  4. Potential utility of hyperbaric oxygen therapy and propolis in enhancing the leishmanicidal activity of glucantime.

    Science.gov (United States)

    Ayres, Diana Copi; Fedele, Thiago Antonio; Marcucci, Maria Cristina; Giorgio, Selma

    2011-01-01

    In this study we investigated the efficacy of hyperbaric oxygen (HBO) therapy, alone or combined with the pentavalent antimonial glucantime on Leishmania amazonensis infection. In parallel, the effect of Brazilian red propolis gel (propain) alone or combined with glucantime on L. amazonensis infection was evaluated. The inhibition of the infection in macrophages treated with glucantime in combination with HBO exposition was greater than that of macrophages treated with glucantime alone or HBO alone. The susceptible mouse strain BALB/c infected in the shaved rump with L. amazonensis treated with glucantime and exposed to HBO showed: time points in the course of the disease in which lesions were smaller than those of mice treated with glucantime alone and revascularization of the skin in the lesion site; interferon-gamma (IFN-g) levels were not elevated in lymph node cells from these animals. Propain alone was not efficient against lesions, although less exudative lesions were observed in animals treated with propain alone or combined with glucantime. These results reveal the potential value of HBO and red propolis in combination with glucantime for treating cutaneous leishmaniasis and encourage further studies on the effect of more aggressive HBO, propolis and glucantime therapies on different mouse models of leishmaniasis.

  5. The Effects of Hyperbaric Oxygen Therapy on Post-Training Recovery in Jiu-Jitsu Athletes.

    Directory of Open Access Journals (Sweden)

    Braulio Henrique Magnani Branco

    Full Text Available The present study aimed to evaluate the effects of using hyperbaric oxygen therapy during post-training recovery in jiu-jitsu athletes.Eleven experienced Brazilian jiu-jitsu athletes were investigated during and following two training sessions of 1h30min. Using a cross-over design, the athletes were randomly assigned to passive recovery for 2 hours or to hyperbaric oxygen therapy (OHB for the same duration. After a 7-day period, the interventions were reversed. Before, immediately after, post 2 hours and post 24 hours, blood samples were collected to examine hormone concentrations (cortisol and total testosterone and cellular damage markers [creatine kinase (CK, aspartate aminotransferase (AST, alanine aminotransferase (ALT, and lactate dehydrogenase (LDH]. Moreover, the rating of perceived exertion (RPE and recovery (RPR scales were applied.Final lactate [La] values (control: 11.9 ± 1.4 mmol/L, OHB: 10.2 ± 1.4 mmol/L and RPE [control: 14 (13-17 a.u., OHB: 18 (17-20 a.u.] were not significantly different following the training sessions. Furthermore, there was no difference between any time points for blood lactate and RPE in the two experimental conditions (P>0.05. There was no effect of experimental conditions on cortisol (F1,20 = 0.1, P = 0.793, η2 = 0.00, small, total testosterone (F1,20 = 0.03, P = 0.877, η2 = 0.00, small, CK (F1,20 = 0.1, P = 0.759, η2 = 0.01, small, AST (F1,20 = 0.1, P = 0.761, η2 = 0.01, small, ALT (F1,20 = 0.0, P = 0.845, η2 = 0.00, small or LDH (F1,20 = 0.7, P = 0.413, η2 = 0.03, small. However, there was a difference between the two experimental conditions in RPR with higher values at post 2 h and 24 h in OHB when compared to the control condition (P<0.05.Thus, it can be concluded that OHB exerts no influence on the recovery of hormonal status or cellular damage markers. Nonetheless, greater perceived recovery, potentially due to the placebo effect, was evident following the OHB condition.

  6. 糖尿病足溃疡的高压氧治疗%Hyperbaric oxygen therapy in diabetic foot

    Institute of Scientific and Technical Information of China (English)

    胡慧军; 张齐; 潘晓雯

    2011-01-01

    Recently, the incidence of both diabetes mellitus and diabetic foot has been increasing.Ischemia, neuropathy, and infection are major causes of diabetic foot ulcer. In addition to other conventional treatments, hyperbaric oxygen is an effective adjunctive therapy with less side-effects. Hyperbaric oxygen may play a role through different mechanisms in improving the prognosis of diabetic foot.%近年来,糖尿病和糖尿病足的发病率在逐年上升,缺血、神经病变和感染是糖尿病足溃疡形成的主要病因.除常规治疗手段以外,高压氧是一种有效的辅助治疗手段.该方法针对病因,副作用少,可通过不同的机制发挥作用,改善患者的预后.

  7. There may be a role for hyperbaric oxygen therapy in transient osteoporosis of the hip.

    Science.gov (United States)

    Mutluoglu, Mesut; Sonmez, Guner; Sivrioglu, Ali Kemal; Ay, Hakan

    2012-10-01

    Transient osteoporosis of the hip (TOH) is a rare clinical condition with usually an unknown aetiology and which typically develops in middle-aged men, or in women in the third trimester of their pregnancy. It is characterized by transient osteopenia and by gradually increasing pain associated with a limitation of the range of motion of the hip. Bone marrow oedema is a typical but nonspecific finding in TOH. A 33-year-old female patient presented with severe hip pain one month after delivery. Her history was unremarkable except for a Hashimoto's Disease of 8 years' duration. Magnetic resonance imaging (MRI) showed significant bone marrow oedema with increased signal intensity in the femoral head on T2-weighted images. A diagnosis of TOH was made and the patient received a total of 30 sessions of hyperbaric oxygen (HBO) at 2.4 ATA, 2 hours each, in a multiplace chamber. Over the course of HBO treatment, her pain was gradually relieved and she became asymptomatic after one month together with a complete recovery of the range of motion of the hip. MRI of the hips 10 weeks after onset of HBO therapy showed normal signal intensity on T2-weighted images.

  8. Hyperbaric oxygen therapy of angiopathic changes in patients with inherited gene imbalance

    Directory of Open Access Journals (Sweden)

    Brkić Predrag

    2007-01-01

    Full Text Available Introduction Phenotype match inherited by genes is in most cases present in monozygotic twins. Their phenotypic resemblance is unfortunately characterized by strong susceptibility for the development of chronic non-infectious diseases. One of the most common non-infectious chronic diseases that are phenotipically represented in twins is diabetes mellitus. Genetic imbalance is, in most cases, placed in 2, 3, 7, 8, 11, 12, 19 and 20 chromosomal pair of the human genome. CASE OUTLINE This study describes a pair of monozygotic twins, aged 54, who were diagnosed for diabetes type 2 ten years earlier. The first patient had trophic changes of muscles and skin tissues of the lower limb, and a necrotic wound on his right leg tibial region with the claudication distance of 50 m. After arteriography, he was referred by a vascular surgeon for hyperbaric oxygen therapy (HBO. HBO protocol implied 70 min. application of 100% oxygen at 2.5 absolute atmospheres. After the first series of HBO therapies consisting of 20 HBO treatments, claudication was eliminated and the necrotic wound healed. Next, surgical aortofemoral bypass was done. During the second HBO treatment, his monozygotic twin brother presented with angiopathic changes due to diabetes. In both patients, biochemical parameters corresponded to the expected level for diabetes type 2 imbalance, and the localization of the chromosomal defect (placed on 3, 11 and 19 chromosomal pair was also in accordance with the respective disorder. After they were included into next 10 HBO treatments, Doppler imaging of the major arteries of limbs revealed normal findings. Conclusion Identical genetic impairment in monozygotic twins can lead to identical somatic changes with resultant consequences. HBO treatment of such patients associated with other therapeutic procedures (conducted by diabetologist, vascular surgeon and physiatrist can postpone or prevent irreversible changes occurring due to blood vessel disorders.

  9. The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic Metastatic Cancer

    OpenAIRE

    2013-01-01

    INTRODUCTION: Abnormal cancer metabolism creates a glycolytic-dependency which can be exploited by lowering glucose availability to the tumor. The ketogenic diet (KD) is a low carbohydrate, high fat diet which decreases blood glucose and elevates blood ketones and has been shown to slow cancer progression in animals and humans. Abnormal tumor vasculature creates hypoxic pockets which promote cancer progression and further increase the glycolytic-dependency of cancers. Hyperbaric oxygen therap...

  10. Neuroprotection of hyperbaric oxygen therapy in sub-acute traumatic brain injury:not by immediately improving cerebral oxygen saturation and oxygen partial pressure

    Institute of Scientific and Technical Information of China (English)

    Bao-chun Zhou; Li-jun Liu; Bing Liu

    2016-01-01

    Although hyperbaric oxygen (HBO) therapy can promote the recovery of neural function in patients who have suffered traumatic brain injury (TBI), the underlying mechanism is unclear. We hypothesized that hyperbaric oxygen treatment plays a neuroprotective role in TBI by increasing regional transcranial oxygen saturation (rSO2) and oxygen partial pressure (PaO2). To test this idea, we compared two groups:a control group with 20 healthy people and a treatment group with 40 TBI patients. The 40 patients were given 100% oxygen of HBO for 90 minutes. Changes in rSO2 were measured. The controls were also examined for rSO2 and PaO2, but received no treatment. rSO2 levels in the patients did not differ signiifcantly after treatment, but levels before and after treatment were signiifcantly lower than those in the control group. PaO2 levels were signiifcantly decreased after the 30-minute HBO treatment. Our ifndings suggest that there is a disorder of oxygen metabolism in patients with sub-acute TBI. HBO does not immediately affect cerebral oxygen metabolism, and the underlying mechanism still needs to be studied in depth.

  11. Ozone Therapy and Hyperbaric Oxygen Treatment in Lung Injury in Septic Rats

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    Levent Yamanel, Umit Kaldirim, Yesim Oztas, Omer Coskun, Yavuz Poyrazoglu, Murat Durusu, Tuncer Cayci, Ahmet Ozturk, Seref Demirbas, Mehmet Yasar, Orhan Cinar, Salim Kemal Tuncer, Yusuf Emrah Eyi, Bulent Uysal, Turgut Topal, Sukru Oter, Ahmet Korkmaz

    2011-01-01

    Full Text Available Various therapeutic protocols were used for the management of sepsis including hyperbaric oxygen (HBO therapy. It has been shown that ozone therapy (OT reduced inflammation in several entities and exhibits some similarity with HBO in regard to mechanisms of action. We designed a study to evaluate the efficacy of OT in an experimental rat model of sepsis to compare with HBO. Male Wistar rats were divided into sham, sepsis+cefepime, sepsis+cefepime+HBO, and sepsis+cefepime+OT groups. Sepsis was induced by an intraperitoneal injection of Escherichia coli; HBO was administered twice daily; OT was set as intraperitoneal injections once a day. The treatments were continued for 5 days after the induction of sepsis. At the end of experiment, the lung tissues and blood samples were harvested for biochemical and histological analysis. Myeloperoxidase activities and oxidative stress parameters, and serum proinflammatory cytokine levels, IL-1β and TNF-α, were found to be ameliorated by the adjuvant use of HBO and OT in the lung tissue when compared with the antibiotherapy only group. Histologic evaluation of the lung tissue samples confirmed the biochemical outcome. Our data presented that both HBO and OT reduced inflammation and injury in the septic rats' lungs; a greater benefit was obtained for OT. The current study demonstrated that the administration of OT as well as HBO as adjuvant therapy may support antibiotherapy in protecting the lung against septic injury. HBO and OT reduced tissue oxidative stress, regulated the systemic inflammatory response, and abated cellular infiltration to the lung demonstrated by findings of MPO activity and histopathologic examination. These findings indicated that OT tended to be more effective than HBO, in particular regarding serum IL-1β, lung GSH-Px and histologic outcome.

  12. Recovery from Repeated Sudden Hearing Loss in a Patient with Takayasu’s Arteritis Treated with Hyperbaric Oxygen Therapy: The First Report in the Literature

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    Massimo Ralli

    2017-01-01

    Full Text Available Hearing loss has been rarely reported in Takayasu’s arteritis, may present as Sudden Sensorineural Hearing Loss, and usually responds well to corticosteroid therapy. Hyperbaric Oxygen Therapy is commonly used as a supplementary treatment to corticosteroids for Sudden Sensorineural Hearing Loss. We present the case of a 36-year-old woman with Takayasu’s arteritis who had two episodes of sudden hearing loss involving one ear at a time with an 11-month delay between each episode. During the first episode, the patient was treated with high-dose intramuscular corticosteroids with a temporary improvement of auditory threshold that deteriorated 14 days after cessation of therapy. In the second episode, Hyperbaric Oxygen Therapy was associated with corticosteroids, with improvements in both ears, including the one that was unresponsive in the long term to previous pharmacologic therapy. In this case, Hyperbaric Oxygen Therapy could have acted synergically with corticosteroids playing a role in hearing restoration.

  13. Subacute normobaric oxygen and hyperbaric oxygen therapy in drowning, reversal of brain volume loss: a case report

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    Paul G Harch

    2017-01-01

    Full Text Available A 2-year-old girl experienced cardiac arrest after cold water drowning. Magnetic resonance imaging (MRI showed deep gray matter injury on day 4 and cerebral atrophy with gray and white matter loss on day 32. Patient had no speech, gait, or responsiveness to commands on day 48 at hospital discharge. She received normobaric 100% oxygen treatment (2 L/minute for 45 minutes by nasal cannula, twice/day since day 56 and then hyperbaric oxygen treatment (HBOT at 1.3 atmosphere absolute (131.7 kPa air/45 minutes, 5 days/week for 40 sessions since day 79; visually apparent and/or physical examination-documented neurological improvement occurred upon initiating each therapy. After HBOT, the patient had normal speech and cognition, assisted gait, residual fine motor and temperament deficits. MRI at 5 months after injury and 27 days after HBOT showed near-normalization of ventricles and reversal of atrophy. Subacute normobaric oxygen and HBOT were able to restore drowning-induced cortical gray matter and white matter loss, as documented by sequential MRI, and simultaneous neurological function, as documented by video and physical examinations.

  14. alpha-Lipoic acid supplementation inhibits oxidative damage, accelerating chronic wound healing in patients undergoing hyperbaric oxygen therapy.

    Science.gov (United States)

    Alleva, Renata; Nasole, Emanuele; Di Donato, Ferruccio; Borghi, Battista; Neuzil, Jiri; Tomasetti, Marco

    2005-07-29

    Hyperbaric oxygen (HBO) therapy is successfully used for the treatment of a variety of conditions. However, prolonged exposure to high concentrations of oxygen induces production of reactive oxygen species, causing damage to the cells. Thus, antioxidant supplementation has been proposed as an adjuvant to attenuate such deleterious secondary effects. We evaluated the effects of alpha-lipoic acid (LA) in patients affected by chronic wounds undergoing HBO treatment. LA supplementation efficiently reduces both the lipid and DNA oxidation induced by oxygen exposure. LA exerted its antioxidant activity by directly interacting with free radicals or by recycling vitamin E. An inhibitory effect of LA on the pro-inflammatory cytokine interleukin-6 was observed. Taken together, we demonstrated an adjuvant effect of LA in HBO therapy used for impaired wound healing treatment. We propose that LA may be used to further promote the beneficial effects of HBO therapy.

  15. Hyperbaric oxygen therapy can diminish fibromyalgia syndrome--prospective clinical trial.

    Directory of Open Access Journals (Sweden)

    Shai Efrati

    Full Text Available Fibromyalgia Syndrome (FMS is a persistent and debilitating disorder estimated to impair the quality of life of 2-4% of the population, with 9:1 female-to-male incidence ratio. FMS is an important representative example of central nervous system sensitization and is associated with abnormal brain activity. Key symptoms include chronic widespread pain, allodynia and diffuse tenderness, along with fatigue and sleep disturbance. The syndrome is still elusive and refractory. The goal of this study was to evaluate the effect of hyperbaric oxygen therapy (HBOT on symptoms and brain activity in FMS.A prospective, active control, crossover clinical trial. Patients were randomly assigned to treated and crossover groups: The treated group patients were evaluated at baseline and after HBOT. Patients in the crossover-control group were evaluated three times: baseline, after a control period of no treatment, and after HBOT. Evaluations consisted of physical examination, including tender point count and pain threshold, extensive evaluation of quality of life, and single photon emission computed tomography (SPECT imaging for evaluation of brain activity. The HBOT protocol comprised 40 sessions, 5 days/week, 90 minutes, 100% oxygen at 2ATA. Sixty female patients were included, aged 21-67 years and diagnosed with FMS at least 2 years earlier. HBOT in both groups led to significant amelioration of all FMS symptoms, with significant improvement in life quality. Analysis of SPECT imaging revealed rectification of the abnormal brain activity: decrease of the hyperactivity mainly in the posterior region and elevation of the reduced activity mainly in frontal areas. No improvement in any of the parameters was observed following the control period.The study provides evidence that HBOT can improve the symptoms and life quality of FMS patients. Moreover, it shows that HBOT can induce neuroplasticity and significantly rectify abnormal brain activity in pain related areas

  16. Hyperbaric oxygen therapy augments tobramycin efficacy in experimental Staphylococcus aureus endocarditis.

    Science.gov (United States)

    Lerche, C J; Christophersen, L J; Kolpen, M; Nielsen, P R; Trøstrup, H; Thomsen, K; Hyldegaard, O; Bundgaard, H; Jensen, P Ø; Høiby, N; Moser, C

    2017-09-01

    Staphylococcus aureus infective endocarditis (IE) is a serious disease with an in-hospital mortality of up to 40%. Improvements in the effects of antibiotics and host responses could potentially benefit outcomes. Hyperbaric oxygen therapy (HBOT) represents an adjunctive therapeutic option. In this study, the efficacy of HBOT in combination with tobramycin in S. aureus IE was evaluated. A rat model of S. aureus IE mimicking the bacterial load in humans was used. Infected rats treated subcutaneously with tobramycin were randomised into two groups: (i) HBOT twice daily (n = 13); or (ii) normobaric air breathing (non-HBOT) (n = 17). Quantitative bacteriology, cytokine expression, valve vegetation size and clinical status were assessed 4 days post-infection. Adjunctive HBOT reduced the bacterial load in the aortic valves, myocardium and spleen compared with the non-HBOT group (P = 0.004, <0.001 and 0.01, respectively) and improved the clinical score (P <0.0001). Photoplanimetric analysis and weight of valve vegetations showed significantly reduced vegetations in the HBOT group (P <0.001). Key pro-inflammatory cytokines [IL-1β, IL-6, keratinocyte-derived chemokine (KC) and vascular endothelial growth factor (VEGF)] were significantly reduced in valves from the HBOT group compared with the non-HBOT group. In conclusion, HBOT augmented tobramycin efficacy as assessed by several parameters. These findings suggest the potential use of adjunctive therapy in severe S. aureus IE. Copyright © 2017 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.

  17. Typological Features of Circulation in Anemic Animals During Infusion Therapy and Hyperbaric Oxygenation

    Directory of Open Access Journals (Sweden)

    Yu. M. Tumanovsky

    2007-01-01

    Full Text Available Objective: to study systemic hemodynamic changes, by taking into account the typological features of a blood circulatory device in anemic animals when therapeutic measures were implemented.Materials and methods. Experiments were made on 58 dogs in 3 series of experiments: 1 20 animals under hemorrhagic shock (a control group; 2 18 anemic animals receiving further infusion therapy; and 3 20 anemic animals exposed to hyperbaric oxygenation (HBO (pO2 = 300 kPa; 60-min session. In each series, animals with eukinetic, hypokinetic, and hyperkinetic circulations were identified. Cardiac and stroke indices (CI and SI, left ventricular stroke output index (LVSOI, specific peripheral vascular resistance (SPVR, double product (DP, heart rate, and blood pressure (BP were determined at the baseline, at 30- and 90-minute shock and after treatment.Results. In the late posthemorrhagic period (at min 90, the preferential preponderance of hyperkinetic circulation in untreated animals in the late stage was characterized by the exhaustion of cardiovascular compensatory reactions and attended by a reduction in BP and central hemodynamic parameters (CI, SI, LVSOI and evolving tachycardia. In the animals with all typological groups, infusion therapy produced a short-term impact on the activation of compensatory hemodynamic reactions, by increasing vascular tone with relatively low baseline central hemodynamic values, which was due to the fact that the heart was overloaded with the excess volume of an infusion mixture and myocardial contractility was diminished. Under HBO, recovery of the baseline ratio of circulatory types increased cardiac functional reserves and eliminated myocardial hypoxia (DP normalization.Conclusion. In hypoxia, recovery of hemodynamic homeostasis in anemic animals is determined by the optimization of adaptive functional mechanisms responsible for circulatory regulation.  

  18. [Hyperbaric oxygen therapy in rats submitted to hepatic veins ligation: mortality valuation and histological study of liver and spleen].

    Science.gov (United States)

    Costa-Val, Ricardo; Nunes, Tarcizo Afonso; Oliveira e Silva, Roberto Carlos de; Souza, Tatiana Karina De Puy e

    2006-01-01

    To evaluate the effects of hyperbaric oxygen therapy in rats submitted to instantaneously hepatic vein obstruction. 30 Holtzman adult male rats were utilised, distributed into two groups: 1) hepatic vein obstruction; 2) hepatic vein obstruction associated with hyperbaric oxygen therapy. General anaesthesia was utilized by a solution composed of ketamine chloride (40 mg/ml) and meperidine chloride (10 mg/ml) in a dose of 50/mg/weight, applied into the right gluteus muscle. The animals belonged to group 2 were submitted to hyperbaric oxygen therapy, 8 hours after the operations, in a 2,5 atmosphere, which lasts 120 minutes per day, in consecutive 20 days. The statistical analysis was made in relation to mortality and histological study of livers and spleens utilizing the Fisher test, and the results were considered statistically significant when p portal and center-lobular veins in five (33.3%), very extensive necrosis of liver cells in seven (46.7%), and light in eight (53.3%), Kupffer cells developed and hypertrophied in 14 (93.3%), high congestion of the spleen purple in six (40.0%) and moderate and severe hemossiderinosis spleen in 14 (93.3%). The analysis of this parameters in the group 2 only showed light necrosis of liver cells, Kupffer cells light developed and hypertrophied, moderated congestion of the spleen purple and light hemossiderinosis spleen. All these parameters analysed showed significantly difference (p oxygen therapy applied in rats, with instantaneously hepatic vein obstruction decreased their post-surgical mortality and their early deleterious effects in the liver and spleen.

  19. Hyperbaric Oxygen Therapy for the Treatment of Diabetic Foot Ulcers: A Health Technology Assessment

    Science.gov (United States)

    Lambrinos, Anna; Chan, Brian; Wells, David; Holubowich, Corinne

    2017-01-01

    Background About 15% to 25% of people with diabetes will develop a foot ulcer. These wounds are often resistant to healing; therefore, people with diabetes experience lower limb amputation at about 20 times the rate of people without diabetes. If an ulcer does not heal with standard wound care, other therapeutic interventions are offered, one of which is hyperbaric oxygen therapy (HBOT). However, the effectiveness of this therapy is not clearly known. The objectives of this health technology assessment were to assess the safety, clinical effectiveness, and cost-effectiveness of standard wound care plus HBOT versus standard wound care alone for the treatment of diabetic foot ulcers. We also investigated the preferences and perspectives of people with diabetic foot ulcers through lived experience. Methods We performed a review of the clinical and economic literature for the effectiveness and cost-effectiveness of hyperbaric oxygen therapy, as well as the budget impact of HBOT from the perspective of the Ministry of Health and Long-Term Care. We assessed the quality of the body of clinical evidence using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) Working Group criteria. To better understand the preferences, perspectives, and values of patients with diabetic foot ulcers and their experience with HBOT, we conducted interviews and administered an online survey. Results Seven randomized controlled trials and one nonrandomized controlled trial met the inclusion criteria. Comparing standard wound care plus HBOT with standard wound care alone, we found mixed results for major amputation rates (GRADE quality of evidence: low), a significant difference in favour of standard wound care plus HBOT on ulcers healed (GRADE quality of evidence: low), and no difference in terms of adverse events (GRADE quality of evidence: moderate). There is a large degree of uncertainty associated with the evaluation of the cost-effectiveness of standard wound

  20. Hyperbaric oxygen therapy for delayed onset muscle soreness and closed soft tissue injury.

    Science.gov (United States)

    Bennett, M; Best, T M; Babul, S; Taunton, J; Lepawsky, M

    2005-10-19

    Soft tissue injuries (including muscle damage after unaccustomed exercise) are common and are often associated with athletic activity. Hyperbaric oxygen therapy (HBOT) is the therapeutic administration of 100% oxygen at environmental pressures greater than one atmosphere. To assess the benefits and harms of HBOT for treating soft tissue injury, including delayed onset muscle soreness (DOMS). We searched the following in July 2004: CENTRAL, MEDLINE, EMBASE, CINAHL, DORCTIHM and reference lists from relevant articles. Relevant journals were handsearched and researchers in the field contacted. Randomised trials comparing the effect on closed soft tissue injury (including DOMS) of therapeutic regimens which include HBOT with those that exclude HBOT (with or without sham therapy). Four reviewers independently evaluated study quality and extracted data. Most of the data presented in the review were extracted from graphs in the trial reports. Nine small trials involving 219 participants were included. Two trials compared HBOT versus sham therapy on acute closed soft tissue injuries (ankle sprain and medial collateral knee ligament injury respectively). The other seven trials examined the effect of HBOT on DOMS following eccentric exercise in unconditioned volunteers. All 32 participants of the ankle sprain trial returned to their normal activities. There were no significant differences between the two groups in time to recovery, functional outcomes, pain, or swelling. There was no difference between the two groups in knee function scores in the second acute injury trial; however, intention-to-treat analysis was not possible for this trial. Pooling of data from the seven DOMS trials showed significantly and consistently higher pain at 48 and 72 hours in the HBOT group (mean difference in pain score at 48 hours [0 to 10 worst pain] 0.88, 95% CI 0.09 to 1.67, P = 0.03) in trials where HBOT was started immediately. There were no differences between the two groups in longer

  1. Hyperbaric oxygen therapy for non-healing ulcers in diabetes mellitus: an evidence-based analysis.

    Science.gov (United States)

    2005-01-01

    To examine the effectiveness and cost-effectiveness of hyperbaric oxygen therapy (HBOT) to treat people with diabetes mellitus (DM) and non-healing ulcers. This policy appraisal systematically reviews the published literature in the above patient population, and applies the results and conclusions of the review to current health care practices in Ontario, Canada. Although HBOT is an insured service in Ontario, the costs for the technical provision of this technology are not covered publicly outside the hospital setting. Moreover, access to this treatment is limited, because many hospitals do not offer it, or are not expanding capacity to meet the demand. Diabetes mellitus is a chronic disease characterized by an increase in blood sugar that can lead to many severe conditions such as vision, cardiac, and vascular disorders. The prevalence of DM is difficult to estimate, because some people who have the condition are undiagnosed or may not be captured through data that reflect access to the health care system. The Canadian Diabetic Association estimates there are about 2 million people in Canada with diabetes (almost 7% of the population). According to recent data, the prevalence of DM increased from 4.72% of the population aged 20 years and over in 1995, to 6.19% of the population aged 20 years and over in 1999, or about 680,900 people in 1999. Prevalence estimates expanded to 700,000 in 2003. About 10% to 15% of people with DM develop a foot wound in their lifetimes because of underlying peripheral neuropathy and peripheral vascular disease. This equals between 70,000 and 105,000 people in Ontario, based on the DM prevalence estimate of 700,000 people. Without early treatment, a foot ulcer may fester until it becomes infected and chronic. Chronic wounds are difficult to heal, despite medical and nursing care, and may lead to impaired quality of life and functioning, amputation, or even death. Hyperbaric oxygen therapy has been in use for about 40 years. It is

  2. Hyperbaric oxygen therapy in the treatment of diabetic foot ulcers--prudent or problematic: a case report.

    Science.gov (United States)

    Mutluoglu, Mesut; Uzun, Günalp; Yildiz, Senol

    2010-06-01

    Hyperbaric oxygen (HBO) therapy is increasingly used in the management of problem wounds, notably diabetic foot ulcers. However, concerns about unnecessary, inappropriate, and prolonged use of this adjunctive treatment exist. A case report of a 52-year-old patient with diabetes mellitus, Charcot foot, and a nonhealing plantar ulcer who had received HBO treatments only illustrates these concerns. He presented with normal pedal pulses, adequate transcutaneous partial oxygen pressure levels, no offloading footwear, and a heavily contaminated ulcer (Pseudomonas spp.). Following a course of oral antibiotics, appropriate topical wound care, and offloading instructions, the wound healed within 3 months. Advanced wound therapy modalities are only indicated for use in patients when accepted standards of wound care, including identification and correction of underlying disorders and comorbidities, have failed. To prevent misuse/overuse of HBO therapy, stand-alone HBO centers should include a multidisciplinary wound care team.

  3. [Efficacy of hyperbaric oxygen therapy in the treatment of ischemic toe ulcer in a patient presenting systemic sclerosis].

    Science.gov (United States)

    Poirier, E; Wind, H; Cordel, N

    2017-01-01

    The medical treatment of ischemic ulcers in patients with systemic sclerosis remains difficult. Despite the major help provided by vasodilator treatments, the risk of spontaneous or surgical amputation remains high. A 48-year-old female patient from Guadeloupe was treated in our department for diffuse systemic sclerosis present for 15 years complicated by lung, joint and digestive involvement, and associated with severe Raynaud's phenomenon. The clinical course was marked by the occurrence of multiple ischemic ulcers, which were resistant to conventional medical treatment and resulted in two surgical amputations (to the 2nd and 3rd interphalangeal joints of the toes of the left foot). Treatment with an endothelin-receptor antagonist and a calcium inhibitor was then introduced for secondary prevention. Two years later, the patient consulted for a further ischemic ulcer of the left 4th toe. She refused the proposed treatment with iloprost. Because of the unfavorable outcome and the absence of therapeutic alternative to amputation, hyperbaric oxygen therapy was initiated. Thirty 90-minutes sessions of pure oxygen at 2.5 ATA were conducted over a 10-week period. Complete healing was obtained after 8 months. We report herein a clinical case illustrating the efficacy of hyperbaric oxygen therapy for the treatment of ischemic ulcers of the toes in systemic sclerosis. It could offer an alternative therapeutic option, in particular for patients presenting resistant ischemic ulcers and a contraindication for or intolerance to the conventional medical treatment. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  4. Alternobaric and hyperbaric oxygen therapy in the immediate and long-term treatment of Menière's disease.

    Science.gov (United States)

    Fattori, B; De Iaco, G; Vannucci, G; Casani, A; Ghilardi, P L

    1996-01-01

    Forty-five patients suffering from Menière's disease were submitted to pressure chamber therapy: 20 with constant pressure (2.2 ATA, hyperbaric treatment) and 25 with continuous variations in pressure levels (from 1.7 to 2.2 ATA, alternobaric treatment). Oxygenation therapy consisted of one session per day lasting 90 minutes for 15 days during the acute attacks followed by five consecutive sessions per month during a follow-up of two years. For a control group we used 18 patients treated with 10 per cent intravenous glycerol during the acute episode and 8 mg tid of betahistine thereafter. We compared hearing loss, vertigo and tinnitus in the three groups 15 days after starting treatment and at the end of the follow-up, according to the criteria suggested by the 1995 Committee on Hearing and Equilibrium. We found no statistically significant differences in recovery from the cochlear-vestibular symptoms in the three groups at the end of the first 15 days of therapy, whereas hyperbaric and, in particular, alternobaric treatment permitted a significant control of the principal attacks of vertigo during the follow-up period. Hearing loss also showed a more significant and more persistent improvement in the patients treated with alternobaric oxygenation compared to the patients in the other two groups.

  5. [Use of hyperbaric oxygenation for wound management].

    Science.gov (United States)

    Berner, Juan Enrique; Vidal, Pedro; Will, Patrick; Castillo, Pablo

    2014-12-01

    Hyperbaric oxygenation consists in exposing patients to increased gas pressures while inhaling pure oxygen. It involves the use of hyperbaric chambers that can double or triple gas pressure inside them. Hyperbaric oxygenation may be useful in different clinical situations, but mostly for the treatment of decompression syndrome. In the last decades, it has been used for the management of different kinds of wounds. Hyperbaric oxygenation not only increases the delivery of oxygen to damaged tissues, but also stimulates angiogenesis, collagen synthesis, stem cell migration and local immune response. Clinical trials that have addressed the use of hyperbaric oxygenation are difficult to compare due to their heterogeneity in terms of experimental design, kind of injuries involved and assessment of outcome. Even though, most studies support the concept that hyperbaric oxygenation accelerates the healing process.

  6. Effects of hyperbaric oxygen therapy in enhancing expressions of e-NOS, TNF-α and VEGF in wound healing

    Science.gov (United States)

    Susilo, Imam; Devi, Anita; Purwandhono, Azham; Hadi Warsito, Sunaryo

    2017-05-01

    Wound healing is a physiological process that occurs progressively through overlapping phases. Tissue oxygenation is an important part of the complex regulation for wound healing. Hyperbaric Oxygen (HBO) therapy is a method of increasing oxygen delivery to tissues. The therapy improves tissue oxygenation and stimulates the formation of H2O2 as a secondary messenger for Tumour Necrosis Factor alpha (TNF α), e-NOS, VEGF and Nuclear Factor Kappa Beta phosphorylation (NF-Kb) which play an important role in the rapid transcription of a wide variety of genes in response to extracellular stimuli. This study aims to determine the effects of Hyperbaric Oxygen therapy in enhancing the expressions of e-NOS, TNF-α, VEGF and wound healing. This study is an animal study with a ‘randomized control group of pre-test and post test design’ on 28 Wistar rats. Randomly, the rats were divided into 4 groups with 7 rats in each group. The HBO treatment group 1 received 5 sessions of HBO 2.4 ATA in 3 × 30 minutes; the HBO treatment group 2 received 10 sessions of HBO 2.4 ATA in 3 × 30 minutes; and each of the control groups were without HBO. Each of the 28 male rats were given a full thickness excisional wound of 1 × 1cm. Examinations of e-NOS, TNF-α, VEGF expressions and wound healing were performed on day-0 (pre-HBO) and day-5 HBO or on day-0 (pre-HBO) and day-10 HBO. The resultsshowthat the Hyperbaric Oxygen therapy can improve e-NOS (p=0.02), TNF-α (p= 0.02), VEGF expression (p=0.02) and wound healing (p=0.002) significantly in the provision of HBO 2.4 ATA for 3 × 30 minutes in 5 sessions over 5 consecutive days. While the 10 sessions of HBO 2.4 ATA for 3 × 30 minutes over 10 consecutive days only increase e-NOS (p=0.02), TNF-α (p=0.04), VEGF expression significantly (p=0.03) but do not improve wound healing significantly (p=0.3) compared with no HBO. The study concludes that HBO can improve the expressions of e-NOS, TNF-α, VEGF and wound healing in the provision of HBO

  7. Effect of growth hormone, hyperbaric oxygen and combined therapy on the gastric serosa

    Science.gov (United States)

    Adas, Gokhan; Adas, Mine; Arikan, Soykan; Sarvan, Ahu Kemik; Toklu, Akin Savas; Mert, Selva; Barut, Gul; Kamali, Sedat; Koc, Bora; Tutal, Firat

    2013-01-01

    AIM: To investigate the role of growth hormone (GH), hyperbaric oxygen therapy (HBOT) and combined therapy on the intestinal neomucosa formation of the gastric serosa. METHODS: Forty-eight male Wistar-albino rats, weighing 250-280 g, were used in this study. The rats were divided into four groups (n = 12): Group 1, control, gastric serosal patch; Group 2, gastric serosal patch + GH; Group 3, gastric serosal patch + HBOT; and Group 4, gastric serosal patch + GH + HBOT. Abdominal access was achieved through a midline incision, and after the 1-cm-long defect was created in the jejunum, a 1 cm × 1 cm patch of the gastric corpus was anastomosed to the jejunal defect. Venous blood samples were taken to determine the insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 3 (IGFBP-3) basal levels. HBOT was performed in Groups 3 and 4. In Groups 2 and 4, human GH was given subcutaneously at a dose of 2 mg per kg/d for 28 d, beginning on the operation day. All animals were sacrificed 60 d after surgery. The jejunal segment and the gastric anastomotic area were excised for histological examination. The inflammatory process, granulation, collagen deposition and fibroblast activity at the neomucosa formation were studied and scored. Additionally, the villus density, villus height, and crypt depth were counted and recorded. The measurements of villus height and crypt depth were calculated with an ocular micrometer. New vessel growth was determined by calculatingeach new vessel in a 1 mm2 area. RESULTS: In the histological comparison of groups, no significant differences were observed between the control group and Groups 2 and 3 with respect to epithelialization, granulation, fibroblastic activity and the inflammatory process, but significant differences were present between the control group and all others groups (Groups 2-4) with respect to angiogenesis (P < 0.01) and collagen deposition (P < 0.05, P < 0.01). Significant differences between the

  8. Neuroprotective effect of hyperbaric oxygen therapy in a juvenile rat model of repetitive mild traumatic brain injury

    Directory of Open Access Journals (Sweden)

    Lei Huang

    2016-01-01

    Full Text Available Repetitive mild traumatic brain injury (rmTBI is an important medical concern for adolescent athletes that can lead to long-term disabilities. Multiple mild injuries may exacerbate tissue damage resulting in cumulative brain injury and poor functional recovery. In the present study, we investigated the increased brain vulnerability to rmTBI and the effect of hyperbaric oxygen treatment using a juvenile rat model of rmTBI. Two episodes of mild cortical controlled impact (3 days apart were induced in juvenile rats. Hyperbaric oxygen (HBO was applied 1 hour/day × 3 days at 2 atmosphere absolute consecutively, starting at 1 day after initial mild traumatic brain injury (mTBI. Neuropathology was assessed by multi-modal magnetic resonance imaging (MRI and tissue immunohistochemistry. After repetitive mTBI, there were increases in T2-weighted imaging-defined cortical lesions and susceptibility weighted imaging-defined cortical microhemorrhages, correlated with brain tissue gliosis at the site of impact. HBO treatment significantly decreased the MRI-identified abnormalities and tissue histopathology. Our findings suggest that HBO treatment improves the cumulative tissue damage in juvenile brain following rmTBI. Such therapy regimens could be considered in adolescent athletes at the risk of repeated concussions exposures.

  9. Rehabilitation of oral function in head and neck cancer patients after radiotherapy with implant-retained dentures : Effects of hyperbaric oxygen therapy

    NARCIS (Netherlands)

    Schoen, P.J.; Raghoebar, G.M.; Bouma, J.; Reintsema, H.; Vissink, A.; Sterk, W.; Roodenburg, J.L.N.

    2007-01-01

    Surgical treatment of malignancies in the oral cavity and subsequent radiotherapy often result in an anatomic and physiological oral condition unfavorable for prosthodontic rehabititation. The objective of this prospective study was to assess the effect of hyperbaric oxygen therapy on treatment outc

  10. How to Get Hyperbaric Oxygen Therapy for Children with Cerebral Palsy or Brain Injury: Navigating Insurance Denials, Red Tape, and Other Challenges

    Science.gov (United States)

    Console, Richard P., Jr.

    2010-01-01

    Medical professionals who use hyperbaric oxygen therapy (HBOT) say that recent studies, as well as anecdotal evidence, indicate that this treatment significantly improves the lives of many children with cerebral palsy and other types of chronic brain injury. So why do many children with these diagnoses not have access to this treatment? Simply…

  11. Complete recovery following hyperbaric oxygen therapy in idiopathic sudden sensorineural hearing loss--a report of two cases.

    Science.gov (United States)

    Agrawal, Swati; Sharma, Nishi

    2016-01-01

    Idiopathic sudden sensorineural hearing loss (ISSHL), a common otologic emergency, presents mostly as an abrupt onset unilateral hearing loss, aural fullness, often with vertigo and tinnitus, usually upon awakening in the morning. Its etiopathogenesis is multifactorial, so a number of different therapeutic regimens are in practice, hyperbaric oxygen (HBO2) therapy being an effective yet underutilized one. Not all cases recover completely even after treatment. Here we describe two cases of ISSHL, diagnosed on the basis of clinical examination and pure-tone audiometry, who had a complete recovery following administration of HBO2 therapy in addition to medical treatment. These cases are reported to highlight the effectiveness of this modality in a physician's armamentarium.

  12. Prevention of avascular necrosis in displaced talar neck fractures by hyperbaric oxygenation therapy: A dual case report

    Directory of Open Access Journals (Sweden)

    Mei-Dan O

    2008-01-01

    Full Text Available Talar neck fractures are a rare injury that account for less then 2% of all foot fractures. Displaced fractures are associated with an exceedingly high rate of avascular necrosis (AVN. The incidence of AVN following Hawkins Type 3 fractures of the talar neck may approach 100%, particularly if diagnosis and reduction are delayed. Severe cases may present as pain and disability of the ankle and the subtalar joints due to a talar dome collapse, resulting in degenerative changes that usually require hind foot arthrodesis. We present two cases of traumatic displaced talar neck fractures which were treated surgically more than 2 weeks following injury due to a delay in diagnosis. Both patients underwent hyperbaric oxygen therapy (HBOT after the operation and neither resulted in AVN of the talus in a three-year follow-up. We suggest that this favorable result may be due to the beneficial effects of HBOT.

  13. Hyperbaric oxygen therapy in the treatment of osteonecrosis of the femoral head: a review of the current literature.

    Science.gov (United States)

    Uzun, Gunalp; Mutluoglu, Mesut; Ersen, Omer; Yildiz, Senol

    2016-01-01

    To review the current literature on the use of hyperbaric oxygen (HBO₂) therapy in the treatment of osteonecrosis of the femoral head (ONFH). We searched PubMed, Directory of Open Access Journals (DOAJ), EMBASE, Web of Science, Academic Search Complete, CINAHL and MEDLINE through April 2015. We hand-searched relevant textbooks, conference proceedings and the reference lists of review articles and clinical studies Randomized controlled trials (RCT) and observational studies (cohort study, case-control study, case series) that reported the outcome of patients who received HBO₂therapy for ONFH were included. Only English-language articles were included. Study quality was not used as an exclusion criterion. Two authors independently assessed trials for inclusion, extracted data and presented to other authors. Disagreements were resolved by consensus. We identified eight clinical studies; two randomized controlled trials (RCTs); one historically controlled study; and five case series. The majority of the studies were small-scale, heterogeneous and methodologically weak. In four of the studies HBO₂therapy was combined with other treatment modalities, making it impossible to draw firm conclusions on the specific effects of HBO₂therapy. Hip survivorship in studies wherein HBO₂therapy was used alone was 95.5% in Steinberg Stage I lesions, 89% in Steinberg Stage II lesions and 100% in Ficat Stage II lesions. There is a room for HBO₂therapy in the management ONFH. Further RCTs, however, are required to better elucidate the role of HBO₂therapy in the treatment of ONFH.

  14. Effect of acute and delayed hyperbaric oxygen therapy on cyanide whole blood levels during acute cyanide intoxication

    DEFF Research Database (Denmark)

    Lawson-Smith, P; Jansen, E C; Hilsted, Linda Maria

    2011-01-01

    causing depletion of adenosine triphosphate. Hyperbaric oxygen (HBO2) is recommended for treating carbon monoxide poisoning. The therapeutic effect is due to a high oxygen pressure removing carbon monoxide from the cells. We hypothesise that HBO2 induces changes in whole-blood-cyanide by a competitive...

  15. Crohn's disease and hyperbaric oxygen therapy Doença de Crohn e oxigenoterapia hiperbárica

    Directory of Open Access Journals (Sweden)

    Leonardo Estenio Iezzi

    2011-01-01

    Full Text Available PURPOSE: Evaluate the application of Hyperbaric Oxygen Therapy (HBO in patients with Crohn's disease (CD refractory to pharmacologic therapy, who developed abdominal, anorectal or skin complications. METHODS: Fourteen selected patients with refractory CD and treated at the School of Medicine of Ribeirao Preto, University of Sao Paulo (FMRP-USP and at the Center of Hyperbaric Medicine, São Paulo Hospital (CEMEHI were submitted to HBO. RESULTS: Of the 14 patients evaluated, 11 had a satisfactory response. CONCLUSION: HBO has shown benefits in patients with CD refractory to pharmacologic therapy.OBJETIVOS: Avaliar a aplicação da Oxigenoterapia Hiperbárica (HBO nos pacientes com doença de Crohn (CD, refratários a terapia farmacológica, que evoluíram com complicações abdominais, orificiais ou dermatológicas. MÉTODOS: Catorze pacientes selecionados no Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo e no Centro de Medicina Hiperbárica do Hospital São Paulo de Ribeirão Preto eram portadores de Doença de Crohn refratária ao tratamento farmacológico e foram submetidos a sessões de HBO. RESULTADOS: Dos 14 pacientes avaliados, 11 apresentaram resposta satisfatória. CONCLUSÃO: A HBO tem demonstrado benefício nos pacientes com Doença de Crohn refratários ao tratamento farmacológico.

  16. Non-Toxic Metabolic Management of Metastatic Cancer in VM Mice: Novel Combination of Ketogenic Diet, Ketone Supplementation, and Hyperbaric Oxygen Therapy

    OpenAIRE

    2015-01-01

    The Warburg effect and tumor hypoxia underlie a unique cancer metabolic phenotype characterized by glucose dependency and aerobic fermentation. We previously showed that two non-toxic metabolic therapies - the ketogenic diet with concurrent hyperbaric oxygen (KD+HBOT) and dietary ketone supplementation - could increase survival time in the VM-M3 mouse model of metastatic cancer. We hypothesized that combining these therapies could provide an even greater therapeutic benefit in this model. Mic...

  17. Hyperbaric oxygen treatment for haemorrhagic radiation cystitis

    Energy Technology Data Exchange (ETDEWEB)

    Bevers, R.F.M.; Kurth, K.H. [Amsterdam Univ. (Netherlands). Academic Medical Center; Bakker, D.J. [Amsterdam Univ. (Netherlands). Depts. of Urology and Surgery

    1995-09-23

    Radiation-induced severe haemorrhagic cystitis is difficult to treat. Conventional treatments may decrease haematuria but do not affect the radiocystitis itself. Hyperbaric oxygen treatment has been reported to do both. We report the results of a prospective study of hyperbaric oxygen (20 sessions of 100% oxygen inhalation at 3 bar for 90 min in a multiplace hyperbaric chamber) to 40 patients with biopsy-proven radiation cystitis and severe haematuria. Haematuria disappeared completely or improved in 37 patients after treatment. Mean follow-up was 23.1 months (range 1-74); and the recurrence rate was 0.12/year. There were no adverse effects. Hyperbaric oxygen treatment should be considered for patients with severe radiation-induced haematuria. (author).

  18. Report on Hyperbaric Oxygen Therapy: An Overlooked Therapeutic Option in Stroke Recovery and a Potential Source of Health Sector Revenue and Health Tourism.

    Science.gov (United States)

    Lowe, S; Le Mercier du Quesnay, D R; Gayle, Pmh; Henry-Pinnock, F; Wedderburn-Buddo, T

    2015-06-30

    This is a special case report on Jamaica's first use of hyperbaric oxygen therapy (HBOT) in stroke recovery, presented at the 56(th) Annual Conference of the Association of Surgeons in Jamaica, Kingston, Jamaica. The literature and story behind the trial ‒ covering case history, diagnosis and discussion of outcome ‒ technical issues, costing, insurance and possibilities for income earning and health tourism are explored.

  19. Hyperbaric Oxygen Therapy in the Treatment of Chronic Mild-Moderate Blast-Induced Traumatic Brain Injury Post-Concussion Syndrome (PCS) and Post Traumatic Stress Disorder (PTSD)

    Science.gov (United States)

    2016-10-01

    secure funding. There are no study results to report at this time and no significant adverse advents. 15. SUBJECT TERMS HBOT: hyperbaric oxygen...therapy; TBI: traumatic brain injury; PPCS: persistent post-concussion syndrome 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18...published 11/2011 in the Journal of Neurotrauma (http://www.liebertonline.com/doi/abs/10.1089/ neu .2011 .1895). The original purpose of the present

  20. [Hyperbaric oxygen and radiotherapy: From myth to reality].

    Science.gov (United States)

    Espenel, S; Raffoux, C; Vallard, A; Garcia, M-A; Guy, J-B; Rancoule, C; Ben Mrad, M; Langrand-Escure, J; Trone, J-C; Pigne, G; Diao, P; Magné, N

    2016-07-01

    Worldwide, more than a million people receive each year a curative radiotherapy. While local control and overall survival are steadily increasing, 5 to 15% of patients still develop above grade 2 late toxicities. Late toxicities treatments are complex. Hyperbaric oxygenation was shown to induce revascularization and healing of injured tissues, but indications are still debated. Through a literature review, we summarized the hyperbaric oxygenation indications in radiation-induced late toxicities. We also studied the knowledge and practice of French local radiation therapists. It seems that hyperbaric oxygen therapy can be a conservative treatment of haemorrhagic cystitis and radiation-induced pain, in case of drug therapies failure. Often associated with a significant morbidity and mortality, surgery could be avoided. The risk of complications in case of tooth extraction in irradiated tissues is also reduced. However, the role of hyperbaric oxygenation for mandibular osteoradionecrosis, radiation-induced proctitis, enteritis, lymphoedema, brachial plexopathy, skin and neurological sequelae seems more questionable since studies results are conflicting. Future outcomes of phase III studies are expected to clarify the role of hyperbaric oxygenation in the management of radio-induced toxicities, including for head and necks complications.

  1. Study on the effect of hyperbaric oxygen therapy on the wound healing and the related serum indexes of rectal abscess patients after surgery

    Institute of Scientific and Technical Information of China (English)

    Bo Mo; Qing He; Juan Ma; Bing Xu

    2016-01-01

    Objective:To observe and research the influence degree of hyperbaric oxygen therapy on wound healing and related serum indexes of rectal abscess patients after surgery. Methods:A total of 48 rectal abscess patients treated with operation in my hospital from April 2014 to August 2015 were taken as research objects, and the 48 patients were randomly divided into two groups:control group (postoperative routine treatments, 24 cases) and observation group (postoperative routine treatments and hyperbaric oxygen therapy, 24 cases), and then compared the time constitutes of wound healing, the edema degrees and the related serum indexes of patients in two test groups before the operation and at 1 d, 3 d and 10 d after operation. Results:The time constitute of wound healing of observation group is better than that of control group, and the edema degree and the related serum index of observation group are lower than those of control group, and the test result of two groups have significant differences. Conclusions:The hyperbaric oxygenation therapy can effectively promote the postoperative wound healing of patients with rectal abscess, and it also has active clinical significance for the control of edema and related serum indexes.

  2. Efficacy comparison of oral steroid, intratympanic steroid, hyperbaric oxygen and oral steroid + hyperbaric oxygen treatments in idiopathic sudden sensorineural hearing loss cases.

    Science.gov (United States)

    Alimoglu, Yalcin; Inci, Ender; Edizer, Deniz Tuna; Ozdilek, Alper; Aslan, Mehmet

    2011-12-01

    Idiopathic sudden sensorineural hearing loss is a rare disorder of unknown pathogenesis in which hearing is lost partially or totally. About 60 treatment modalities have been described. We aimed to compare the efficacy of hyperbaric oxygen, oral steroid, intratympanic steroid therapy and their combinations in idiopathic sudden sensorineural hearing loss patients. Files of patients who were followed up between 2004 and 2010 in our clinic were examined retrospectively. Patients were divided into four groups according to the therapy received: Oral steroid, oral steroid + hyperbaric oxygen, intratympanic steroid and hyperbaric oxygen. Treatment success was assessed by Siegel criteria and mean gains using pre-treatment and post-treatment audiograms. 217 patients and 219 ears were examined. The proportion of patients responding to therapy was the highest in the oral steroid + hyperbaric oxygen group with 86.88% (53/61) followed by the oral steroid group with 63.79% (37/58), the intratympanic steroid group with 46,51% (20/43) and the hyperbaric oxygen group with 43.85% (25/57). The proportion of patients who had complete recovery was the highest in the oral steroid + hyperbaric oxygen group with 42.6% (26/61) followed by the oral steroid group with 19.0% (11/58), the hyperbaric oxygen group with 17.5% (10/57) and the intratympanic steroid group with 11.6% (5/43). The oral steroid + hyperbaric oxygen group has the highest mean hearing gain among all groups (p sudden sensorineural hearing loss patients receiving oral steroid + hyperbaric oxygen combination therapy have a higher likelihood of recovery than patients receiving oral steroids, hyperbaric oxygen or intratympanic steroids alone.

  3. The clinical and economic potential of hyperbaric oxygen therapy in the treatment of diabetic ulceration and other conditions.

    Science.gov (United States)

    McMillan, Grant; Glover, Mark

    2007-09-01

    Selective use of systemic hyperbaric oxygen therapy (HBOT) is a treatment that deserves further study and analysis. The current situation in the United Kingdom (UK) is discussed in relation to available evidence and practices elsewhere. It would appear that there is increasing evidence that HBOT could benefit many patients and health care budgets through improved clinical efficacy and cost-efficiency in the treatment of specific conditions, notably nonhealing diabetic ulceration of the lower limbs. This is not only disabling, it may lead to amputation. It is also a financial burden to patients and health service providers. In the UK, it is estimated that chronic wound care costs more than pound1 billion a year, with diabetic ulceration accounting for a substantial part of that staggering sum. It has been said repeatedly, and quite correctly, that there is insufficient good-quality evidence upon which a properly informed decision may be made on the contribution HBOT might make to alleviate that situation. It is intriguing that no determined effort is apparent that would seek to settle the issue by encouraging and facilitating appropriately designed and conducted randomized controlled trials to assess the actual effects of this treatment. Indeed, a proposed government research initiative appears to have been cancelled. Is lack of research preventing provision of HBOT?

  4. Anti-inflammatory effects of hyperbaric oxygen on irradiated laryngeal tissues.

    Science.gov (United States)

    Arıcıgil, Mitat; Dündar, Mehmet Akif; Yücel, Abitter; Arbağ, Hamdi; Arslan, Abdullah; Aktan, Meryem; Fındık, Sıdıka; Kılınç, İbrahim

    2017-02-27

    To manage the complications of irradiation of head and neck tissue is a challenging issue for the otolaryngologist. Definitive treatment of these complications is still controversial. Recently, hyperbaric oxygen therapy is promising option for these complications. In this study, we used biochemical and histopathological methods to investigate the efficacy of hyperbaric oxygen against the inflammatory effects of radiotherapy in blood and laryngeal tissues when radiotherapy and hyperbaric oxygen are administered on the same day. Thirty-two Wistar Albino rats were divided into four groups. The control group was given no treatment, the hyperbaric oxygen group was given only hyperbaric oxygen therapy, the radiotherapy group was given only radiotherapy, and the radiotherapy plus hyperbaric oxygen group was given both treatments on the same day. Histopathological and biochemical evaluations of specimens were performed. Serum tumor necrosis factor-α, interleukin-1β, and tissue inflammation levels were significantly higher in the radiotherapy group than in the radiotherapy plus hyperbaric oxygen group, whereas interleukin-10 was higher in the radiotherapy plus hyperbaric oxygen group. When radiotherapy and hyperbaric oxygen are administered on the same day, inflammatory cytokines and tissue inflammation can be reduced in an early period of radiation injury. Copyright © 2017 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved.

  5. MRI findings of otic and sinus barotrauma in patients with carbon monoxide poisoning during hyperbaric oxygen therapy.

    Directory of Open Access Journals (Sweden)

    Ping Wang

    Full Text Available BACKGROUND AND PURPOSE: To study the MRI findings of otic and sinus barotrauma in patients with carbon monoxide(CO poisoning during hyperbaric oxygen (HBO therapy and examine the discrepancies of otic and sinus abnormalities on MRI between barotrauma and acute otitis media with effusion. MATERIALS AND METHODS: Eighty patients with CO-poisoning diagnosed with otic and sinus barotrauma after HBO therapy were recruited. Brain MRI was performed to predict delayed encephalopathy. Over the same period, 88 patients with acute otitis media with effusion on MRI served as control. The abnormalities of the middle ear and paranasal sinuses on MRI were noted and were compared between groups. Nine patients with barotrauma were followed up by MRI. RESULTS: In the barotrauma group, 92.5% of patients had bilateral middle ear abnormalities on MRI, and 60% of patients had both middle ear cavity and mastoid cavity abnormalities on MRI in both ears. Both rates were higher than those in the control group (p = 0.000. In the two groups, most abnormalities on MRI were observed in the mastoid cavity. The rate of sinus abnormalities of barotrauma was 66.3%, which was higher than the 50% in the control group (p = 0.033. In the nine patients with barotrauma followed up by MRI, the otic barotrauma and sinus abnormalities had worsened in 2 patients and 5 patients, respectively. CONCLUSION: MRI is able to depict the abnormalities of otic and sinus barotrauma in patients with CO-poisoning during HBO therapy and to differentiate these from acute otitis media with effusion.

  6. Patient's perspectives on hyperbaric oxygen treatment of osteoradionecrosis

    DEFF Research Database (Denmark)

    Lee, Anne; Forner, L.; Jansen, E. C.

    2014-01-01

    Osteoradionecrosis (ORN) is a known complication to radiation therapy for head and neck cancer with a prevalence of 5-7% among radiated patients. Treatment might include dental surgery and reconstruction of the jawbone as well as hyperbaric oxygen treatment (HBOT). HBOT takes place in a closed...

  7. Hyperbaric oxygen therapy ameliorates local brain metabolism, brain edema and inflammatory response in a blast-induced traumatic brain injury model in rabbits.

    Science.gov (United States)

    Zhang, Yongming; Yang, Yanyan; Tang, Hong; Sun, Wenjiang; Xiong, Xiaoxing; Smerin, Daniel; Liu, Jiachuan

    2014-05-01

    Many studies suggest that hyperbaric oxygen therapy (HBOT) can provide some clinically curative effects on blast-induced traumatic brain injury (bTBI). The specific mechanism by which this occurs still remains unknown, and no standardized time or course of hyperbaric oxygen treatment is currently used. In this study, bTBI was produced by paper detonators equivalent to 600 mg of TNT exploding at 6.5 cm vertical to the rabbit's head. HBO (100% O2 at 2.0 absolute atmospheres) was used once, 12 h after injury. Magnetic resonance spectroscopy was performed to investigate the impact of HBOT on the metabolism of local injured nerves in brain tissue. We also examined blood-brain barrier (BBB) integrity, brain water content, apoptotic factors, and some inflammatory mediators. Our results demonstrate that hyperbaric oxygen could confer neuroprotection and improve prognosis after explosive injury by promoting the metabolism of local neurons, inhibiting brain edema, protecting BBB integrity, decreasing cell apoptosis, and inhibiting the inflammatory response. Furthermore, timely intervention within 1 week after injury might be more conducive to improving the prognosis of patients with bTBI.

  8. Hyperbaric oxygen therapy as a potential treatment for post-traumatic stress disorder associated with traumatic brain injury

    Science.gov (United States)

    Eve, David J; Steele, Martin R; Sanberg, Paul R; Borlongan, Cesar V

    2016-01-01

    Traumatic brain injury (TBI) describes the presence of physical damage to the brain as a consequence of an insult and frequently possesses psychological and neurological symptoms depending on the severity of the injury. The recent increased military presence of US troops in Iraq and Afghanistan has coincided with greater use of improvised exploding devices, resulting in many returning soldiers suffering from some degree of TBI. A biphasic response is observed which is first directly injury-related, and second due to hypoxia, increased oxidative stress, and inflammation. A proportion of the returning soldiers also suffer from post-traumatic stress disorder (PTSD), and in some cases, this may be a consequence of TBI. Effective treatments are still being identified, and a possible therapeutic candidate is hyperbaric oxygen therapy (HBOT). Some clinical trials have been performed which suggest benefits with regard to survival and disease severity of TBI and/or PTSD, while several other studies do not see any improvement compared to a possibly poorly controlled sham. HBOT has been shown to reduce apoptosis, upregulate growth factors, promote antioxidant levels, and inhibit inflammatory cytokines in animal models, and hence, it is likely that HBOT could be advantageous in treating at least the secondary phase of TBI and PTSD. There is some evidence of a putative prophylactic or preconditioning benefit of HBOT exposure in animal models of brain injury, and the optimal time frame for treatment is yet to be determined. HBOT has potential side effects such as acute cerebral toxicity and more reactive oxygen species with long-term use, and therefore, optimizing exposure duration to maximize the reward and decrease the detrimental effects of HBOT is necessary. This review provides a summary of the current understanding of HBOT as well as suggests future directions including prophylactic use and chronic treatment. PMID:27799776

  9. A prospective randomized controlled trial assessing the efficacy of adjunctive hyperbaric oxygen therapy in the treatment of hidradenitis suppurativa.

    Science.gov (United States)

    Yildiz, Hamza; Senol, Levent; Ercan, Erdinc; Bilgili, Memet Ersan; Karabudak Abuaf, Ozlem

    2016-02-01

    Hyperbaric oxygen therapy (HBOT) appears to enhance wound healing, increase bactericidal activity, and act synergistically with a number of antibiotics. The aim of this study was to evaluate the efficacy of HBOT as an adjunctive therapy in patients with hidradenitis suppurativa (HS) treated with a combination of systemic rifampicin and clindamycin. The study was a prospective, single-center, single-dose, open-label, randomized controlled clinical study of HBOT in patients with moderate to severe HS. Efficacy was measured by modified Sartorius score (SS), HS Severity Index (HSSI), Dermatology Life Quality Index (DLQI), and a visual analog scale (VAS) before treatment and after the completion of 4 and 10 weeks of treatment. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels were also measured. Forty-three patients were enrolled in the study. More patients in the HBOT than in the control group showed a decrease of ≥50% from baseline parameters at week 10 for SS (100%), HSSI (100%), DLQI (95.5%), VAS (100%), ESR (100%), and CRP (72.7%). Clinically and statistically significant improvements from baseline were observed at 4 and 10 weeks in HSSI (P = 0.009 at both), SS (P = 0.021 at both), and DLQI (P = 0.044 at week 4, P = 0.009 at week 10). Adjunctive HBOT was considered to be effective in significantly improving antibiotic treatment of HS. The treatment was well tolerated, and no unexpected safety issues were identified.

  10. Non-Toxic Metabolic Management of Metastatic Cancer in VM Mice: Novel Combination of Ketogenic Diet, Ketone Supplementation, and Hyperbaric Oxygen Therapy.

    Science.gov (United States)

    Poff, A M; Ward, N; Seyfried, T N; Arnold, P; D'Agostino, D P

    2015-01-01

    The Warburg effect and tumor hypoxia underlie a unique cancer metabolic phenotype characterized by glucose dependency and aerobic fermentation. We previously showed that two non-toxic metabolic therapies - the ketogenic diet with concurrent hyperbaric oxygen (KD+HBOT) and dietary ketone supplementation - could increase survival time in the VM-M3 mouse model of metastatic cancer. We hypothesized that combining these therapies could provide an even greater therapeutic benefit in this model. Mice receiving the combination therapy demonstrated a marked reduction in tumor growth rate and metastatic spread, and lived twice as long as control animals. To further understand the effects of these metabolic therapies, we characterized the effects of high glucose (control), low glucose (LG), ketone supplementation (βHB), hyperbaric oxygen (HBOT), or combination therapy (LG+βHB+HBOT) on VM-M3 cells. Individually and combined, these metabolic therapies significantly decreased VM-M3 cell proliferation and viability. HBOT, alone or in combination with LG and βHB, increased ROS production in VM-M3 cells. This study strongly supports further investigation into this metabolic therapy as a potential non-toxic treatment for late-stage metastatic cancers.

  11. Non-Toxic Metabolic Management of Metastatic Cancer in VM Mice: Novel Combination of Ketogenic Diet, Ketone Supplementation, and Hyperbaric Oxygen Therapy.

    Directory of Open Access Journals (Sweden)

    A M Poff

    Full Text Available The Warburg effect and tumor hypoxia underlie a unique cancer metabolic phenotype characterized by glucose dependency and aerobic fermentation. We previously showed that two non-toxic metabolic therapies - the ketogenic diet with concurrent hyperbaric oxygen (KD+HBOT and dietary ketone supplementation - could increase survival time in the VM-M3 mouse model of metastatic cancer. We hypothesized that combining these therapies could provide an even greater therapeutic benefit in this model. Mice receiving the combination therapy demonstrated a marked reduction in tumor growth rate and metastatic spread, and lived twice as long as control animals. To further understand the effects of these metabolic therapies, we characterized the effects of high glucose (control, low glucose (LG, ketone supplementation (βHB, hyperbaric oxygen (HBOT, or combination therapy (LG+βHB+HBOT on VM-M3 cells. Individually and combined, these metabolic therapies significantly decreased VM-M3 cell proliferation and viability. HBOT, alone or in combination with LG and βHB, increased ROS production in VM-M3 cells. This study strongly supports further investigation into this metabolic therapy as a potential non-toxic treatment for late-stage metastatic cancers.

  12. 高压氧治疗减压性骨坏死的疗效探讨%Effect of hyperbaric oxygen therapy on dysbaric osteonecrosis

    Institute of Scientific and Technical Information of China (English)

    李慈; 方以群; 蒋功达; 王杰; 朱祥祺; 孙永军; 马骏

    2010-01-01

    目的 探讨高压氧(HBO)治疗减压性骨坏死的疗效及主要影响因素.方法 13例男性减压性骨坏死患者,在HBO治疗前后,比较临床症状及X线改变.结果 本组病例骨坏死病变集中于股骨、肱骨及胫骨,股骨头/颈和肱骨头最多见.HBO疗效与治疗时程密切相关.结论 HBO治疗减压性骨坏死显示积极的疗效,长期、规范的HBO治疗是提高本病治疗效果的关键.%Objective To explore effect of hyperbaric oxygen therapy on dysbaric osteonecrosis.Methods Thirteen male patients with dysbaric osteonecrosis were given hyperbaric oxygen therapy, and symptoms and changes in X-ray films were compared pre and post HBO therapy. Results In the 13 cases,pathological changes due to osteonecrosis were detected in femur, humerus and cnemis, with femoral head/neck and humeral head being the most common sites. The therapeutic effect of HBO was closely related with the course of HBO therapy. Conclusions HBO therapy had positive effects on dysbaric osteonecrosis, however,long and regular treatment was the key to the enhancement of a desirable therapeutic effect.

  13. RETRACTED: Early hyperbaric oxygen therapy may improve the long term neurological consequences of diabetic patients suffering from hemorrhagic stroke.

    Science.gov (United States)

    Xu, Qian; Wei, Yi-Ting; Fan, Shuang-Bo; Wang, Liang; Zhou, Xiao-Ping

    2017-03-22

    This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of Neuroscience Letters has learned that text throughout this paper duplicates, or nearly duplicates, text in an earlier paper by others (Rusyniak DE, Kirk MA, May JD, Kao LW, Brizendine EJ, Welch JL, Cordell WH, Alonso RJ; Hyperbaric Oxygen in Acute Ischemic Stroke Trial Pilot Study, Stroke. 2003 Feb;34(2):571-4). Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.

  14. [The effect of hyperbaric oxygen therapy to different degree of hearing loss and types of threshold curve in sudden deafness patients].

    Science.gov (United States)

    Liu, Yangyun; Sun, Dajiang; Shao, Shan; Jiang, Wen; Sun, Zhengliang; Li, Zhengxian

    2010-10-01

    To investigate the effect of hyperbaric oxygen therapy to different degrees of hearing loss and different types of threshold curve in sudden deafness patients, and establish a personalized therapy, so as to promote clinical effect to sudden deafness. One hundred and twenty cases were divided into two groups respectively (each group 60 cases). Drug treatment had been used in group A for two weeks. The patients in group B received drug treatment combined with hyperbaric oxygen therapy for two weeks. According to the different degrees of hearing loss and the types of audiogram in two groups, the statistical analysis to the difference of hyperbaric oxygen therapeutic effect was done. The effective rates was statistically different (chi2 = 8.044, P deafness patients. The statistical difference could been found between moderate and the severe deafness, the value of chi2 and p were 4.969, 5.560 and 0.040, 0.035, respectively. In group A, the statistical difference could only been found between mild and the profound deafness patients (chi2 = 6.739, P deafness, the moderate and the profound deafness, the severe and the profound deafness patients. The value of chi2 were 11.500, 15.058,10.221 and P deafness. The statistical difference could been found between the downsloping and the flat audiogram, with the value of chi2 and p were 5.144 and 5.969, P deafness. The value of chi2 were 6.188, 7.247, 8.082 and P deafness and severe deafness, the descending and flat type of audiogram.

  15. Effectiveness of hyperbaric oxygen therapy in irradiated maxillofacial dental implant patients: A systematic review with meta-analysis

    Directory of Open Access Journals (Sweden)

    Darshana Nilesh Shah

    2017-01-01

    Full Text Available The significantly higher implant failure rates in maxillofacial patients, undergoing radiotherapy, might be caused by the long-term effects of reduced vascularization compromising the implantation site. An extensive preclinical animal literature and a multitude of clinical reports suggest the use of hyperbaric oxygen (HBO therapy as it can improve the tissue vascularity. Hence, it may increase the implant survival rate by enhancing osseointegration process in such patients. The objective of this systematic review was to investigate the effectiveness of HBO therapy on dental implant survival rate in irradiated maxillofacial patients who require prosthodontic rehabilitation. An electronic search without time restrictions was undertaken in April 2016 using databases: PubMed, Google Scholar, and the Cochrane Oral Health Group Trials Register. We also tried to contact the manufacturers and researchers in the field for necessary details. Clinical human studies, on irradiated maxillofacial dental implant patients, including randomized controlled trials (RCTs, prospective controlled trials, retrospective studies, and preliminary reports were included in the study. Data collection was carried out by two of the authors' independently. The titles and abstracts of all reports were screened for the study design and type of reported intervention; all the duplicates were removed. The data search yielded 62 titles, out of which 14 articles were selected for the study by the article filtration criteria: Title/abstract/full text. Data which were extracted by two authors with any disagreement were resolved by the third author, and a meta-analysis was done using binary random-effect model. The results show decreased implant failure rate in HBO group (9.21% compared to non-HBO group (22.44%. The potential limitations of this study are amount of radiation doses used, period lasting from radiotherapy to the placement of the implants, and follow-up period which varies

  16. Preservative spleen surgery and hyperbaric oxygen therapy Cirurgia conservadora do baço e oxigenoterapia hiperbárica

    Directory of Open Access Journals (Sweden)

    Isabel Cristina Andreatta Lemos Paulo

    2007-01-01

    Full Text Available PURPOSE: To assess functional and morphological aspects of spleen auto-implants and of the splenic inferior pole of rats, post-operatively treated or not with hyperbaric oxygen, as well as the survival of these animals, were studied. METHODS: Seventy-eight male Wistar rats, weighing between 192 and 283 g ( 238,3 ± 9,6g, were randomly distributed into three groups: Group1-(n=20, spleen manipulation; group 2-(n=36, spleen auto-implantation; group3-(n= 22, subtotal splenectomy preserving the inferior pole. Each group was subdivided as follows: subgroup a, not submitted to hyperbaric oxygen therapy: 1a(n=10, 2a(n=21, 3a(n= 13; subgroup b, submitted to the therapy: 1b(n=10, 2b(n=15, 3b(n=9. Blood was collected pre-operatively and 11 days after surgery, for the estimation of lipids and immunoglobulins and the counting of platelets and Howell-Jolly corpuscles. The spleen and remains were taken for histological study. RESULTS: The number of surviving animals was significantly higher in groups 1(p 2. The macro and microscopic appearance in subgroup 2b were more viable than in subgroup 2a, and that of group 3 more viable than in group 2. The survival of the animals carrying their whole spleen or its inferior pole was more frequent than that of the auto-implanted animals. CONCLUSION: Functionality and viability of the whole spleen or of its inferior pole, were better than in the auto-implanted animals. Hyperbaric oxygentherapy contributed to increased survival frequency of auto -implanted animals, and to improve the functionality and viability of the auto-implants and the function of the inferior splenic pole, and did not interfere in animals carrying their whole spleen.OBJETIVO: Estudar aspectos funcionais e morfológicos dos auto-implantes esplênicos e do pólo inferior do baço de ratos, tratados ou não com oxigênio hiperbárico no pós-operatório, e a sobrevida desses animais. MÉTODOS: Foram operados 78 ratos, machos, Wistar, pesando entre 192 g

  17. Effect of Hyperbaric Oxygen Therapy on whole blood cyanide concentrations in carbon monoxide intoxicated patients from fire accidents

    Directory of Open Access Journals (Sweden)

    Hilsted Linda

    2010-06-01

    Full Text Available Abstract Background Hydrogen cyanide (HCN and carbon monoxide (CO may be important components of smoke from fire accidents. Accordingly, patients admitted to hospital from fire accidents may have been exposed to both HCN and CO. Cyanide (CN intoxication results in cytotoxic hypoxia leading to organ dysfunction and possibly death. While several reports support the use of hyperbaric oxygen therapy (HBO for the treatment of severe CO poisoning, limited data exist on the effect of HBO during CN poisoning. HBO increases the elimination rate of CO haemoglobin in proportion to the increased oxygen partial pressure and animal experiments have shown that in rats exposed to CN intoxication, HBO can increase the concentration of CN in whole blood. Objective The purpose of the present study was to determine whole blood CN concentrations in fire victims before and after HBO treatment. Materials and methods The patients included were those admitted to the hospital because of CO intoxication, either as fire victims with smoke inhalation injuries or from other exposures to CO. In thirty-seven of these patients we measured CN concentrations in blood samples, using a Conway/microdiffusion technique, before and after HBO. The blood samples consisted of the remaining 2 mL from the arterial blood gas analysis. CN concentration in blood from fire victims was compared to 12 patients from non-fire accidents but otherwise also exposed to CO intoxication. Results The mean WB-CN concentration before patients received HBO did not differ significantly between the two groups of patients (p = 0.42. The difference between WB-CN before and after HBO did not differ significantly between the two groups of patients (p = 0.7. Lactate in plasma before and after did not differ significantly between the two groups of patients. Twelve of the 25 fire patients and one of the non-fire patients had been given a dose of hydroxycobalamin before HBO. Discussion and Conclusion CN

  18. Oxigenoterapia hiperbárica como tratamento adjuvante do pioderma gangrenoso Hyperbaric oxygen therapy as an adjuvant treatment for pyoderma gangrenosum

    Directory of Open Access Journals (Sweden)

    Wilson Albieri Vieira

    2011-12-01

    Full Text Available O pioderma gangrenoso é uma dermatose neutrofílica, rara da pele e do tecido subcutâneo, caracterizada por um processo necrosante progressivo e doloroso. A conduta no Pioderma gangrenoso requer, com frequência, o uso de drogas sistêmicas, tais como: corticoides, sulfonas e imunossupressoras, seja de maneira isolada, seja em combinação. Muitos relatos, na literatura, documentam o tratamento com êxito do Pioderma gangrenoso, com a oxigenoterapia hiperbárica. No nosso caso, uma jovem com lesões extensas e muito dolorosas, o tratamento com oxigenoterapia hiperbárica associado ao corticoide e imunossupressor promoveu cicatrização, com excelente resultado, com fechamento rápido da lesão e diminuição do desconforto.Pyoderma Gangrenosum is a rare neutrophilic dermatosis of skin and subcutaneous tissue characterized by a painful and progressive necrotizing process. The management of pyoderma gangrenosum often requires systemic drug therapy, such as corticosteroids, sulfones or immunosuppressants, either alone or in combination. Several reports in the literature document the successful treatment of pyoderma gangrenosum with hyperbaric oxygen therapy. In our case, hyperbaric oxygen therapy associated with corticoids and immunosuppressants promoted healing of large and very painful lesions in an adolescent girl with an excellent outcome, including rapid wound closure and decreased discomfort.

  19. Use of hyperbaric oxygen in postradiation head and neck surgery

    Energy Technology Data Exchange (ETDEWEB)

    Myers, R.A.; Marx, R.E. (Maryland Institute for Emergency Medical Services Systems, Baltimore (USA))

    1990-01-01

    Data are presented to indicate the value of hyperbaric oxygen in all stages of treatment of patients with irradiation complications following head and neck surgery. Hyperbaric oxygen stimulates angiogenesis, with increased neovascularization and optimization of cellular levels of oxygen for osteoblast and fibroblast proliferation, collagen formation, and support of ingrowing blood vessels. The hypoxic, acellular matrix in the postirradiated field is changed to a hypercellular, hyperoxic/normoxic situation. Oxygen is used as an adjunct to appropriate surgery. By using the two modalities together, the salvage rate for osteoradionecrosis and its complications of orocutaneous fistula, pathological fractures, and severe bone losses can be increased dramatically. It may also be used prophylactically in patients with periodontal disease or teeth requiring extraction in a previously irradiated area. Finally, the use of oxygen helps support tissue flaps and grafts placed into previously irradiated areas. Economically, there is considerable cost savings in the use of hyperbaric oxygen therapy with appropriate surgery. From the patient's point of view, pain relief is achieved, function is returned, and prognosis improves in a relatively short time.

  20. Glycosylated hemoglobin and hyperbaric oxygen coverage denials.

    Science.gov (United States)

    Moffat, A D; Worth, E R; Weaver, L K

    2015-01-01

    Some Medicaid and Medicare fiscal intermediaries are denying hyperbaric oxygen (HBO2) therapy for diabetic foot ulcer (DFU) patients if the glycosylated hemoglobin (HbA1c) > 7.0%. We performed multiple PubMed searches for any diabetic wound healing clinical trial that documented HbA1c and had a wound healing endpoint. We scrutinized 30 peer-reviewed clinical trials, representing more than 4,400 patients. The average HbA1c from the intervention side of the studies was 8.6% (7.2% - 9.9%) and the control/sham side was 8.3% (6.0% - 10.6%). Twelve studies made a direct attempt to link HbA1c and wound healing. Four retrospective studies and one prospective cohort study assert that lower HbA1c favors wound healing, but review of the studies reveal design flaws that invalidate these conclusions. In total, 25 studies showed no direct correlation between HbA1c levels and wound healing. There was no randomized controlled trial (RCT) data demonstrating that HbA1c 7.0% is unfounded.

  1. Hyperbaric oxygen therapy for cerebral blood flow and electroencephalogram in patients with acute cerebral infarction Choice for therapeutic occasion

    Institute of Scientific and Technical Information of China (English)

    Lei Chen; Fei Li; Dexiang Gu

    2007-01-01

    BACKGROUND: Hyperbaric oxygen (HBO) therapy increases blood oxygen content, changes cerebral blood flow (CBF) and cerebral metabolism. Its therapeutic effects on cerebrovascular disease have been fully confirmed, but the occasion for HBO therapy is still unclear.OBJECTIVE: To observe the therapeutic effects of HBO therapy at different time on CBF and electroencephalogram (EEG) in patients with acute cerebral infarction (CI).DESIGN: Randomized controlled trial.SETTING: Department of Neurology, Shidong Hospital, Yangpu District of Shanghai.PARTICIPANTS: Ninety-six inpatients with acute CI, admitted to Department of Neurology, Shidong Hospital, Yangpu District of Shanghai from January 2001 to December 2006, were involved in this experiment. The involved participants met the diagnosis criteria of acute CI and confirmed by skull CT or MRI. They all were patients with moderate CI (16- 30 points) according to neurologic deficit score formulated by Chinese Medical Association. Informed consents of detected items and therapeutic regimen were obtained from all the involved participants. They were randomized into two groups with 48 in each:early-stage treatment group and advanced-stage treatment group. Among the 48 patients in the early-stage treatment group, 21 male and 27 female, aged 53 -68 years, 22 patients were found with basal ganglia infarction, 10 with brain lobe infarction, 16 with multiple infarction, 27 accompanied with hypertension and 2 accompanied with diabetes mellitus. Among the 48 patients in the advanced-stage treatment group, 23 male and 25 female, aged 52 - 71 years, 25 patients were found with basal ganglia infarction, 10 with brain lobe infarction, 12 with multiple infarction, 1 with brain stem infarction, 28 accompanied with hypertension and 1 accompanied with diabetes mellitus.METHODS: After admission, patients of two groups received routine drug treatment. ① Patients in the early-stage treatment group and advanced-stage treatment group began to

  2. Hyperbaric Oxygen Therapy Registry

    Science.gov (United States)

    2016-05-18

    Air or Gas Embolism; Carbon Monoxide Poisoning; Clostridial Myositis and Myonecrosis (Gas Gangrene); Crush Injury, Compartment Syndrome & Other Acute Traumatic Ischemias; Decompression Sickness; Peripheral Arterial Insufficiency and Central Retinal Artery Occlusion; Severe Anemia; Intracranial Abscess; Necrotizing Soft Tissue Infections; Osteomyelitis (Refractory); Delayed Radiation Injury (Soft Tissue and Bony Necrosis); Compromised Grafts and Flaps; Acute Thermal Burn Injury; Idiopathic Sudden Sensorineural Hearing Loss

  3. Hyperbaric oxygen in the treatment of a diabetic foot ulcer.

    LENUS (Irish Health Repository)

    Davenport, Colin

    2012-02-01

    Although simultaneous pancreas and kidney transplant improves most complications of type 1 diabetes, suppression of the immune system increases the risk for infection. The authors report the case of a patient who, despite receiving a simultaneous pancreas and kidney transplant, subsequently developed neuro-ischemic ulcers of his right foot requiring repeated amputations. He then developed an infected ulcer of his remaining right big toe, with significant implications for his mobility. This ulcer proved resistant to multiple courses of antibiotics and care in a specialist foot clinic but resolved completely following a course of hyperbaric oxygen therapy. The role of hyperbaric oxygen in diabetic foot ulcers is not yet fully established but should be considered in resistant cases with vascular insufficiency and a significant infective component.

  4. Hyperbaric oxygen in the treatment of a diabetic foot ulcer.

    LENUS (Irish Health Repository)

    Davenport, Colin

    2011-02-01

    Although simultaneous pancreas and kidney transplant improves most complications of type 1 diabetes, suppression of the immune system increases the risk for infection. The authors report the case of a patient who, despite receiving a simultaneous pancreas and kidney transplant, subsequently developed neuro-ischemic ulcers of his right foot requiring repeated amputations. He then developed an infected ulcer of his remaining right big toe, with significant implications for his mobility. This ulcer proved resistant to multiple courses of antibiotics and care in a specialist foot clinic but resolved completely following a course of hyperbaric oxygen therapy. The role of hyperbaric oxygen in diabetic foot ulcers is not yet fully established but should be considered in resistant cases with vascular insufficiency and a significant infective component.

  5. The effects of hyperbaric oxygen therapy on oxidative stress, inflammation, and symptoms in children with autism: an open-label pilot study

    Directory of Open Access Journals (Sweden)

    Melnyk Stepan

    2007-11-01

    Full Text Available Abstract Background Recently, hyperbaric oxygen therapy (HBOT has increased in popularity as a treatment for autism. Numerous studies document oxidative stress and inflammation in individuals with autism; both of these conditions have demonstrated improvement with HBOT, along with enhancement of neurological function and cognitive performance. In this study, children with autism were treated with HBOT at atmospheric pressures and oxygen concentrations in current use for this condition. Changes in markers of oxidative stress and inflammation were measured. The children were evaluated to determine clinical effects and safety. Methods Eighteen children with autism, ages 3–16 years, underwent 40 hyperbaric sessions of 45 minutes duration each at either 1.5 atmospheres (atm and 100% oxygen, or at 1.3 atm and 24% oxygen. Measurements of C-reactive protein (CRP and markers of oxidative stress, including plasma oxidized glutathione (GSSG, were assessed by fasting blood draws collected before and after the 40 treatments. Changes in clinical symptoms, as rated by parents, were also assessed. The children were closely monitored for potential adverse effects. Results At the endpoint of 40 hyperbaric sessions, neither group demonstrated statistically significant changes in mean plasma GSSG levels, indicating intracellular oxidative stress appears unaffected by either regimen. A trend towards improvement in mean CRP was present in both groups; the largest improvements were observed in children with initially higher elevations in CRP. When all 18 children were pooled, a significant improvement in CRP was found (p = 0.021. Pre- and post-parental observations indicated statistically significant improvements in both groups, including motivation, speech, and cognitive awareness (p Conclusion In this prospective pilot study of children with autism, HBOT at a maximum pressure of 1.5 atm with up to 100% oxygen was safe and well tolerated. HBOT did not appreciably

  6. Neurotoxic effects of oxygen in hyperbaric environment: A case report

    Directory of Open Access Journals (Sweden)

    Rabrenović Milorad

    2015-01-01

    Full Text Available Introduction. Oxygen is an essential element of life in aerobic organisms. However, if not controlled, inhalation of oxygen under increased pressure in conditions of hyperbaric oxygen therapy can lead to serious damage and even death. Case report. We presented a 20-year-old male who had begun exhibiting symptoms of epilepsy during diving test in a hyperbaric chamber while inhaling 100% oxygen. He was immediately taken off oxygen mask and started breathing air and began rapid decompression. He lost consciousness, began foaming at the mouth, and had a series of tonic spasms. The patient was previously completely healthy and not on any medications. He was admitted for emergency treatment in our hospital, where he was treated for epilepsy. On admission, he complained of muscle and joint pain, and had erythematous changes on the forehead, neck and chest. All these changes occurred after leaving the hyperbaric chamber. Bloodwork revealed leukocytosis with neutrophil (Leukocytosis 16.0 ´ 109/L (reference values 4.00-11.00 ´ 109/L, Neutrophili 13 ´ 109/L (reference values 1.9-8.0 ´ 109/L, with elevated enzymes aspartate aminotransferase (AST 56 U/L (reference values 0-37 U/L, alanin aminotransferase (ALT 59 U /L, (reference values 25-65 U/L, creatine kinase (CK 649 U/L, (reference values 32-300 U /L, lactate dehydrogenase (LDH 398 U/L (reference values 85- 227 U/L. Because of pain and his condition we began treatment in a hyperbaric chamber at a pressure of 2.0 ATA for 70 minutes, resulting in a reduction of symptoms and objective recovery of the patient. Within 24 h, repeated laboratory tests showed a reduction of leukocytosis (13 ´ 109/L and neutrophils (7.81 ´ 109/L, and the gradual reduction of the enzymes AST (47 U/L, ALT (50 U/L, CK (409 U/L, LDH (325 U/L. Since head CT and EEG were normal, epilepsy diagnosis was ruled out. This fact, along with medical tests, facilitated the differential diagnosis and confirmed that this was a case of

  7. A phase I study of low-pressure hyperbaric oxygen therapy for blast-induced post-concussion syndrome and post-traumatic stress disorder.

    Science.gov (United States)

    Harch, Paul G; Andrews, Susan R; Fogarty, Edward F; Amen, Daniel; Pezzullo, John C; Lucarini, Juliette; Aubrey, Claire; Taylor, Derek V; Staab, Paul K; Van Meter, Keith W

    2012-01-01

    This is a preliminary report on the safety and efficacy of 1.5 ATA hyperbaric oxygen therapy (HBOT) in military subjects with chronic blast-induced mild to moderate traumatic brain injury (TBI)/post-concussion syndrome (PCS) and post-traumatic stress disorder (PTSD). Sixteen military subjects received 40 1.5 ATA/60 min HBOT sessions in 30 days. Symptoms, physical and neurological exams, SPECT brain imaging, and neuropsychological and psychological testing were completed before and within 1 week after treatment. Subjects experienced reversible middle ear barotrauma (5), transient deterioration in symptoms (4), and reversible bronchospasm (1); one subject withdrew. Post-treatment testing demonstrated significant improvement in: symptoms, neurological exam, full-scale IQ (+14.8 points; pPTSD symptoms (PCL-M: pself-report of percent of normal (pPTSD. Significant improvements occurred in symptoms, abnormal physical exam findings, cognitive testing, and quality-of-life measurements, with concomitant significant improvements in SPECT.

  8. Pharmacological preconditioning with hyperbaric oxygen: can this therapy attenuate myocardial ischemic reperfusion injury and induce myocardial protection via nitric oxide?

    Science.gov (United States)

    Yogaratnam, Jeysen Zivan; Laden, Gerard; Guvendik, Lavent; Cowen, Mike; Cale, Alex; Griffin, Steve

    2008-09-01

    Ischemic reperfusion injury (IRI) is an inevitable part cardiac surgery such as coronary artery bypass graft (CABG). While ischemic hypoxia and the ensuing normoxic or hyperoxic reperfusion are critical to the initiation and propagation of IRI, conditioning myocardial cells to an oxidative stress prior to IRI may limit the consequences of this injury. Hyperbaric oxygen (HBO2) is a modality of treatment that is known to generate an oxidative stress. Studies have shown that treatment with HBO2 postischemia and reperfusion is useful in ameliorating myocardial IRI. Moreover, preconditioning the myocardium with HBO2 before reperfusion has demonstrated a myocardial protective effect by limiting the infarct size post ischemia and reperfusion. Current evidence suggests that HBO2 preconditioning may partly attenuate IRI by stimulating the endogenous production of nitric oxide (NO). As NO has the capacity to reduce neutrophil sequestration, adhesion and associated injury, and improve vascular flow, HBO2 preconditioning induced NO may play a role in providing myocardial protection during interventions that involve an inevitable episode of IRI. This current opinion review article attempts to suggest that HBO2 may be used to pharmacologically precondition and protect the myocardium from the effects of IRI that is known to occur during cardiac surgery.

  9. HYPERBARIC OXYGENATION AND AEROBIC PERFORMANCE

    Directory of Open Access Journals (Sweden)

    Irvine D. Prather

    2004-03-01

    Full Text Available The continuing desire to improve performance, particularly at the national and international levels, has led to the use of ergogenic aids. Ergogenic aids are defined as 'a procedure or agent that provides the athlete with a competitive edge beyond that obtained via normal training methods'. Random drug testing has been implemented in an effort to minimize an athlete's ability to gain an unfair advantage. However, other means of improving performance have been tried. Blood doping has been used to enhance endurance performance by improving oxygen delivery to working muscles. As oxygen is carried in combination with the hemoglobin, it seems logical that increasing the number of red blood cells (RBC's in the body would increase the oxygen carrying capacity to the tissues and result in improved performance. The first experiments of removing and then reinfusing blood showed a significant improvement in performance time

  10. Electrotherapy and hyperbaric oxygen: Promising treatments for postradiation complications

    Energy Technology Data Exchange (ETDEWEB)

    King, G.E.; Scheetz, J.; Jacob, R.F.; Martin, J.W. (Univ. of Texas M.D. Anderson Cancer Center, Houston (USA))

    1989-09-01

    Electrotherapy and hyperbaric oxygen therapy have been added to physical therapy to treat patients with postsurgery and radiation sequelae. Problems of reduced oral opening and range of head movement, soft tissue necrosis, osteoradionecrosis, and delayed wound healing were addressed in 37 patients over a 3-year period. Of this group, 16 irradiated maxillary resection patients were specifically followed up to determine the effectiveness of the new modalities on improving reduced oral opening. Although healing and the quality of the soft tissues showed marked improvement there was no significant improvement in oral opening.

  11. [Clinical examination of 3 patients with delayed neuropsychiatric encephalopathy induced by carbon monoxide poisoning, who recovered from severe neurocognitive impairment by repetitive hyperbaric oxygen therapy].

    Science.gov (United States)

    Watanuki, Toshio; Matsubara, Toshio; Higuchi, Naoko; Higuchi, Fumihiro; Inoue, Koji; Otsuchi, Hironobu; Tsuruta, Ryosuke; Watanabe, Yoshifumi

    2014-01-01

    We performed hyperbaric oxygen (HBO) therapy for 3 patients with delayed neuropsychiatric encephalopathy induced by carbon monoxide (CO) poisoning. All patients were male and around 50 years old, and they had not received HBO therapy within 24 h after CO poisoning, even though they showed severe consciousness disturbance. In these patients, delayed neuropsychiatric encephalopathy appeared about 25 days after acute CO poisoning, and HBO therapy was initiated within 8 days after disease onset. Although the condition of 2 of the patients worsened initially, they showed significant improvement of neurocognitive impairment after 30 sessions of HBO therapy. The clinical courses of these patients suggest that the effect of HBO therapy can be evaluated after 30 sessions. To evaluate the validity of the indices of the clinical effect of HBO therapy, we performed brain magnetic resonance imaging, single photon emission computed tomography, electroencephalography (EEG), and neurocognitive tests (HDS-R, and Wechsler Adult Intelligence Scale-Revised or III). Our results showed that changes in EEG signals and neurocognitive tests were closely correlated with the patients' clinical courses.

  12. Hyperbaric oxygenation effects determination in the therapy of chronic occlusive lower extremities arteries disease by the use of perfusion scintigraphy

    Directory of Open Access Journals (Sweden)

    Zoranović Uroš

    2010-01-01

    Full Text Available Background/Aim. Hyperbaric oxygenation (HBO is a medical treatment of a patient with 100% oxygen inspiration under the pressure higher than atmospheric in a special unit designed to let the whole patient's body rest in a chamber. The aim of the study was to determine the effect of the application of HBO treatment on the patient's lower extremities with chonic inoperabile occlusive disease by measning the parameters of perfusion scintigraphy (perfusion reserve, relative perfusion. Methods. This investigation included 22 patients (19 males and 3 famales. Following clinical assessment of lower extremities condition according to the skin appearance and its adnexa, claudication distance was performed. Clinical condition was graded by the use of 5-point nominal scale. In all of the patients 99mTctetraphosmine lower extremities scintigraphy was done ten days prior to the treatment start and ten days after the treatment with HBO. Lower legs were imaged from the posterior view. Prior to imaging the patients were obligatory lying approximately half an hour. Results. In 18 (86% of the patients there was an improvement manifested as better subjective condition and better skin and its adnexa appearance. Following HBO treatment there was a statistically significant change in collecting the radiopharmac at rest. This finding indicates an increased viability of muscles as well as an increased perfusion reserve. Perfusion reserve mean values increased from 39.99 to 50.86%, and from 38.46 to 49.33% for the right and the left lower leg, respectively. This parameter clearly indicates favorable effects of HBO treatment pertaining neoangiogenesis and, consequently, increased viability of the lower leg muscles. It was also obvious in visual analysis of the obtained images. Conclusion. The obtained results confirm that muscle perfusion measured by the parameters of perfusion scintigraphy using 99mTc-tetrophosmine (perfusion reserve, relative perfusion in patients with

  13. Effect of hyperbaric oxygen on the regeneration of experimental crush injuries of nerves

    Directory of Open Access Journals (Sweden)

    Tuma Jr. Paulo

    1999-01-01

    Full Text Available Hyperbaric oxygen has been successfully used on treatment of acute ischemic injuries involving soft tissues and chronic injuries. In nerve crush injuries, the mechanisms involved are very similar to those found in ischemic injuries. Consequently, it is logical to hypothesize that hyperbaric oxygen should improve nerve repair, which is a critical step on functional recovery. In the present study, we created standard nerve crush injuries on sciatic nerves of rats, which underwent treatment with hyperbaric oxygen. Results were assessed by functional evaluation using walking-track analysis. The functional recovery indexes observed did not differ from control group. We concluded that hyperbaric oxygen therapy, in the schedule used, had no influence on functional recovery after nerve crush injuries.

  14. Application of hyperbaric oxygen in liver transplantation

    Directory of Open Access Journals (Sweden)

    Hu Lv

    2016-01-01

    Full Text Available In recent years, hyperbaric oxygen (HBO has been used in the treatment of a lot of diseases such as decompression sickness, arterial gas embolism, carbon dioxide poisoning, soft tissue infection, refractory osteomyelitis, and problematic wound, but little is known about its application in liver transplantation. Although several studies have been conducted to investigate the protective effects of HBO on liver transplantation and liver preservation, there are still some controversies on this issue, especially its immunomodulatory effect. In this short review, we briefly summarize the findings supporting the application of HBO during liver transplantation (including donors and recipients.

  15. The role of hyperbaric oxygen therapy (HOT as an otoprotection agent against cisplatin ototoxicity Efeito otoprotetor da oxigenoterapia hiperbárica na toxicidade causada pela cisplatina

    Directory of Open Access Journals (Sweden)

    Camila C. Yassuda

    2008-01-01

    Full Text Available PURPOSE: Hyperbaric oxygen therapy (HOT consists of intermittent inhalations of 100% oxygen at a pressure higher than 1 atm. It is an important adjuvant therapy in pathological processes like soft tissue infections, radiation injury, gas gangrene, osteomyelitis and decompressive diseases. Cisplatin, a potent antineoplastic drug, widely used in cancer therapy is highly ototoxic causing bilateral, irreversible damage to the hearing of high frequency sounds (4-8 KHz. OBJECTIVE:This experimental study conducted at the Faculty of Medicine of Ribeirao Preto, University of Sao Paulo aims to evaluate Hyperbaric Oxygen Therapy as an otoprotection agent against drug toxicity. METHODS: Albino guinea pigs were divided into two groups: in Group A, 5 animals (10 cochlea received cisplatin, i. p., 8.0 mg/kg/day during three days and afterwards were submitted to HOT; in Group B, 3 animals (6cochlea received cisplatin, i. p. 8.0mg/kg/day during three days. Guinea pigs were evaluated by acoustic otoemissions (AOE and scanning electron microscopy (SEM. RESULTS: Group B animals showed loss of auditory functions as measured by AOE and distorted outer hair cells by SEM. In Group A, outer hair cells shown by SEM images were mostly preserved. CONCLUSION: It is presumed that Hyperbaric Oxygen Therapy has a protector effect against cisplatin ototoxicity.INTRODUÇÃO: A Oxigenoterapia hiperbárica (OHB envolve a inalação de oxigênio a 100% sob uma pressão maior que 1 atm. E um importante modo de terapia adjuvante para processos patológicos, tais como: infecção de partes moles, lesões actínicas, gangrena gasosa, osteomielite e doença descompressiva. A cisplatina e uma potente droga antineoplásica largamente utilizada para o tratamento de câncer. A ototoxicidade e um importante efeito colateral desta droga, causando dano irreversível, bilateral, na capacidade de ouvir sons de alta freqüência (4 - 8 KHz. Este estudo experimental, realizado na Faculdade de

  16. Combined application of dexamethasone and hyperbaric oxygen therapy yields better efficacy for patients with delayed encephalopathy after acute carbon monoxide poisoning

    Directory of Open Access Journals (Sweden)

    Xiang W

    2017-02-01

    Full Text Available Wenping Xiang,1 Hui Xue,2 Baojun Wang,2 Yuechun Li,2 Jun Zhang,2 Changchun Jiang,2 Furu Liang,2 Jiangxia Pang,2 Lehua Yu1 1Department of Rehabilitation Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 2Department of Neurology, Baotou Central Hospital, Baotou, Inner Mongolia, People’s Republic of China Background: Delayed encephalopathy after acute carbon monoxide (CO poisoning (DEACMP commonly occurs after recovering from acute CO poisoning. This study was performed to assess the efficacy of the combined application of dexamethasone and hyperbaric oxygen (HBO therapy in patients with DEACMP.Patients and methods: A total of 120 patients with DEACMP were recruited and randomly assigned into the experimental group (receiving dexamethasone 5 mg/day or 10 mg/day plus HBO therapy and control group (HBO therapy as monotherapy. Meanwhile, the conventional treatments were provided for all the patients. We used the Mini-Mental State Examination (MMSE scale to assess the cognitive function, the National Institutes of Health Stroke Scale (NIHSS to assess the neurological function and the remission rate (RR to assess the clinical efficacy. Myelin basic protein (MBP in the cerebrospinal fluid (CSF was also measured.Results: After 4 weeks of treatment, compared to the control group, the experimental group had a significantly higher remission rate (P=0.032, a significantly higher average MMSE score (P=0.037 and a significantly lower average NIHSS score (P=0.002. Meanwhile, there was a trend toward better improvement with dexamethasone 10 mg/day, and the level of MBP in the CSF of patients was significantly lower in the experimental group than in the control group (P<0.0001. The addition of dexamethasone did not significantly increase the incidence of adverse events.Conclusion: These results indicate that the combined application of dexamethasone and HBO therapy could yield better efficacy for patients with DEACMP and

  17. Hyperbaric oxygen: Primary treatment of radiation-induced hemorrhagic cystitis

    Energy Technology Data Exchange (ETDEWEB)

    Weiss, J.P.; Neville, E.C.

    1989-07-01

    Of 8 patients with symptoms of advanced cystitis due to pelvic radiation treated with hyperbaric oxygen 7 are persistently improved during followup. All 6 patients treated for gross hematuria requiring hospitalization have been free of symptoms for an average of 24 months (range 6 to 43 months). One patient treated for stress incontinence currently is dry despite little change in bladder capacity, implying salutary effect from hyperbaric oxygen on the sphincter mechanism. One patient with radiation-induced prostatitis failed to respond. This experience suggests that hyperbaric oxygen should be considered the primary treatment for patients with symptomatic radiation-induced hemorrhagic cystitis.

  18. 音乐疗法在婴儿高压氧治疗中的应用效果与分析%The application results and analysis of music therapy in the treatment of infants with hyperbaric oxygen

    Institute of Scientific and Technical Information of China (English)

    齐红梅; 白爱兰; 马巧梅

    2014-01-01

    Objective To explore the effect of music therapy in the treatment of hyperbaric oxygen infants .Methods Divided 218 cases of infants admitted by our department from 2012 April to June into two groups,the experimental group and the control group.The experimental group took music therapy with hyperbaric oxygen therapy,and compared the complications and effects with the two groups after treatment .Results The complications in the experimental group were remarkably less than the control group during the hyperbaric oxygen treatment.And the infants crying time was obviously shortened,with the satisfaction of parents of children significantly raised.%目的:探讨音乐疗法在婴儿高压氧治疗中的作用。方法把2012年4月---6月在我科住院的218例进行高压氧治疗的患儿随机分成对照组和实验组,实验组采取音乐疗法配合高压氧治疗,把两组治疗的并发症及效果进行比较。结果实验组在高压氧治疗过程中的并发症明显少于对照组,患儿哭闹的时间明显缩短,患儿家长的满意度明显提高。

  19. Hyperbaric Oxygen Therapy Baby Operation Table Design and Application%婴儿高压氧治疗操作表的设计及应用

    Institute of Scientific and Technical Information of China (English)

    郭志丹; 薛雯

    2009-01-01

    Objective To combine clinical practice,the design of a practical baby hyperbaric oxygen therapy operation table.Methods According to the baby hyperbaric oxygen treatment and time pressure on the characteristics of the design of the treatment of the four models: (1)1.3ATA,30min, (2)l.5ATA,30min, (3)1.5ATA,4Omin, (4)1.7ATA,30min. 200 cases of neonatal hypoxic ischemic eneephalopathy(HIE) in children, according to neonatal behavioral neurological assessment 20(NBNA) to score the results of uniform distribution pattern of 4 treatment groups; 3 months after psychomotor development business (DQ)Assessmeut and comparison.Results The model. (2)is the best model. Conclusion The treatment according to the model. (2)designed for a baby to operate high-pressure oxygen treatment table is very useful.%目的 结合临床实践,设计出一种实用的婴儿高压氧治疗操作表.方法 根据婴儿高压氧治疗压力与时间特点,设计四种治疗模式:(1)1.3ATA,30min;(2)1.5ATA,30min;(3)1.5ATA,40min;(4)1.7ATA,30min.将200例新生儿缺氧缺血性脑病(HIE)患儿,按新生儿行为神经测定20项(NBNA)评分结果均匀分配至4个模式组治疗.3个月后做精神运动发育商(DQ)评估与比较.结果 治疗模式(2)为最佳模式.结论 按治疗模式(Ⅱ)设计的一种婴儿高压氧治疗操作表是非常实用的.

  20. 护理干预在突发性耳聋患者高压氧治疗中的作用%Effect of nursing intervention on hyperbaric oxygen therapy of patients with sudden deafness

    Institute of Scientific and Technical Information of China (English)

    宋月梅

    2016-01-01

    目的:探讨护理干预在突发性耳聋患者高压氧治疗中的应用及效果。方法:180例突发性耳聋患者给予药物联合高压氧治疗,并给予护理干预,观察其疗效。结果:痊愈53例,显效47例,有效66例,无效14例,有效率92.2%;无中耳气压伤等高压氧并发症发生。结论:有效的护理干预可提高突发性耳聋患者高压氧治疗依从性及临床疗效,减少并发症发生,改善患者预后。%Objective:To explore the application and effect of nursing intervention on hyperbaric oxygen therapy of patients with sudden deafness.Methods:180 patients with sudden deafness were given drug combined with hyperbaric oxygen therapy and nursing intervention.The effect was observed.Results:53 cases were cured;47 cases were markedly effective;66 cases were effective;14 cases were ineffective;the effective rate was 92.2%.There was no hyperbaric oxygen complications such as middle ear barotrauma.Conclusion:Effective nursing intervention can improve the treatment compliance and clinical curative effect of hyperbaric oxygen therapy in patients with sudden deafness,reduce the incidence of complications,and improve the prognosis of patients.

  1. [HYPERBARIC OXYGEN THERAPY IN THE TREATMENT OF MALE INFERTILITY ASSOCIATED WITH INCREASED SPERM DNA FRAGMENTATION AND REACTIVE OXYGEN SPECIES IN SEMEN].

    Science.gov (United States)

    Metelev, A Yu; Bogdanov, A B; Ivkinl, E V; Mitrokhin, A A; Vodneva, M M; Veliev, E I

    2015-01-01

    The aim of this study was to explore the potential of hyperbaric oxygenation (HBO) for reduction of sperm DNA fragmentation level and reactive oxygen species (ROS) in semen. The study included 90 men with idiopathic infertility. Patients of the treatment group (n = 60) underwent HBO before the vitro fertilization (IVF) procedure. In the control group (n = 30) IVF was carried out without prior cours of HBO. Sperm DNA fragmentation analysis was carried out using the TUNEL assay, the level of ROS in the ejaculate was measured by chemiluminescence. HBO treatment resulted in a significant decrease in the mean level of sperm DNA fragmentation from 33.2 ± 7.5 to 11.9 ± 5.9%, and the median ROS in sperm from 0.89 to 0.39 mV/s (p < 0.05). In the control group these changes were not statistically significant. Pregnancy after IVF occurred in 63.3% (38/60) of sexual partners of the treatment group men and in 36.7% (11/30) of the control group (p < 0.05). The high efficiency of HBO in overcoming the adverse effects of oxidative stress on sperm parameters allows us to consider it as a promising method for the treatment of men with idiopathic infertility.

  2. Combined application of dexamethasone and hyperbaric oxygen therapy yields better efficacy for patients with delayed encephalopathy after acute carbon monoxide poisoning

    Science.gov (United States)

    Xiang, Wenping; Xue, Hui; Wang, Baojun; Li, Yuechun; Zhang, Jun; Jiang, Changchun; Liang, Furu; Pang, Jiangxia; Yu, Lehua

    2017-01-01

    Background Delayed encephalopathy after acute carbon monoxide (CO) poisoning (DEACMP) commonly occurs after recovering from acute CO poisoning. This study was performed to assess the efficacy of the combined application of dexamethasone and hyperbaric oxygen (HBO) therapy in patients with DEACMP. Patients and methods A total of 120 patients with DEACMP were recruited and randomly assigned into the experimental group (receiving dexamethasone 5 mg/day or 10 mg/day plus HBO therapy) and control group (HBO therapy as monotherapy). Meanwhile, the conventional treatments were provided for all the patients. We used the Mini-Mental State Examination (MMSE) scale to assess the cognitive function, the National Institutes of Health Stroke Scale (NIHSS) to assess the neurological function and the remission rate (RR) to assess the clinical efficacy. Myelin basic protein (MBP) in the cerebrospinal fluid (CSF) was also measured. Results After 4 weeks of treatment, compared to the control group, the experimental group had a significantly higher remission rate (P=0.032), a significantly higher average MMSE score (P=0.037) and a significantly lower average NIHSS score (P=0.002). Meanwhile, there was a trend toward better improvement with dexamethasone 10 mg/day, and the level of MBP in the CSF of patients was significantly lower in the experimental group than in the control group (P<0.0001). The addition of dexamethasone did not significantly increase the incidence of adverse events. Conclusion These results indicate that the combined application of dexamethasone and HBO therapy could yield better efficacy for patients with DEACMP and should be viewed as a potential new therapy. PMID:28260864

  3. Effects of Extracorporeal Shock Wave Therapy Combined with Hyperbaric Oxygen on Nonunion of Long Bone Fractures%冲击波联合高压氧治疗长骨骨折不愈合的疗效分析

    Institute of Scientific and Technical Information of China (English)

    王海东; 杨智权; 张平; 张庆民; 徐啸; 李贵忠; 黄广林; 满立波

    2014-01-01

    Objective To explore the effect of extracorporeal shock wave therapy (ESWT) combined with hyperbaric oxygen on non-union after surgery. Methods 83 patients with nonunion were treated with ESWT combined with hyperbaric oxygen (treatment group), and 32 cases served as control group. ESWT application was conducted using a protocol totaling 3000 shocks per treatment. The treatment group received 3~5 times of treatment, at the same time hyperbaric oxygen therapy was performed. The control group received no treatment and was followed up at least 3 months after treatment. Results The overall success rate was 78.31% in the treatment group, while only 12.50%recovered in the control group (P<0.01). The complications of treatment group were less and negligible. Conclusion Treatment of nonunion by extracorporeal shock wave combined with hyperbaric oxygen is safe and effective.%目的:探讨体外冲击波疗法(ESWT)联合高压氧对骨折不愈合的治疗效果。方法将115例骨折不愈合患者分为ESWT联合高压氧治疗组(治疗组,n=83)和对照组(n=32)。治疗组采用ESWT治疗3~5次,每次治疗冲击计量3000次,期间配合高压氧治疗。对照组继续观察,随访3个月以上。结果治疗组总治愈率为78.31%,对照组为12.50%(P<0.01)。治疗组并发症少且轻微。结论 ESWT联合高压氧治疗骨折不愈合安全有效。

  4. Variations of brain edema and neurological function of rat models of cerebral infarction after hyperbaric oxygen therapy%高压氧干预脑梗死模型大鼠脑水肿及神经功能变化

    Institute of Scientific and Technical Information of China (English)

    田烜

    2015-01-01

    背景:研究认为,高压氧有较好保护脑神经和脑细胞的作用,应用高压氧可使氧分压快速弥撒到相对缺氧的脑组织中,增加脑组织的血氧含量,促进脑水肿及脑神经功能的恢复。目的:观察大脑中动脉阻塞造模后高压氧干预对大鼠脑梗死组织水肿的影响,并探讨其对脑梗死大鼠神经功能保护的可能作用机制。方法:成年雌性SD大鼠65只,造模成功60只,随机区组法分为假手术组、脑梗死组、高压氧组,每组20只,按照线栓线法建立大鼠大脑中动脉阻塞脑梗死模型。造模后3 d,通过TUNEL法检测各实验组大鼠脑梗死区神经细胞的凋亡情况。伤后72 h通过RT-PCR、Western blot检测脑梗死区周围AQP4/9、基质金属蛋白酶9/2基因转录和蛋白的表达,通过苏木精-伊红染色观察脑梗死区病理组织形态学变化,通过免疫组织化学法检测胶质纤维酸性蛋白的表达量,高压氧干预后24 h,3 d及伤后1、2周行Longa行为学评分,检测神经功能的损伤情况。结果与结论:①高压氧组Longa行为学评分在治疗后1,2 d均较脑梗死组显著降低(P <0.05)。②造模后3 d高压氧组细胞凋亡指数均明显低于脑梗死组(P<0.05)。③造模后72 h,与脑梗死组相比高压氧组AQP4/9、基质金属蛋白酶9/2基因和蛋白表达均较显著降低(P<0.05)。结果提示高压氧治疗通过减少大鼠脑梗死区神经细胞的凋亡和降低脑组织水肿,对脑梗死起到保护作用。%BACKGROUND:Several studies have suggested that hyperbaric oxygen could better protect cranial nerve and brain cels. Hyperbaric oxygen therapy can make oxygen partial pressure rapidly diffusing toward relatively hypoxic brain tissue, so as to increase blood oxygen content in the brain tissue, reduce brain edema and promote the recovery of brain function. OBJECTIVE: To observe the effects of hyperbaric oxygen therapy on brain tissue

  5. Influence of hyperbaric oxygenation and its use in urinary tract diseases

    Directory of Open Access Journals (Sweden)

    Skiba Małgorzata

    2016-09-01

    Full Text Available In this publication, we adduce examples of the use of hyperbaric oxygen therapy in urinary tract diseases. Hyperbaric oxygen therapy has been proved to have a positive influence on the kidneys of animals with diabetes, sepsis or undergoing chemotherapy. In the literature, we can also find many examples of the use of hyperbaric therapy with good clinical outcomes in human patients with prostatic hypertrophy, pyelonephritis, and hemorrhagic cystitis. The first trials of this kind of treatment of urinary tract diseases were started at the end of the twentieth century. In spite of the promising results, and numerous reports on the effectiveness of this non-invasive method of treatment, it is not currently used on a regular basis.

  6. Effects of hyperbaric oxygen at 1.25 atmospheres absolute with normal air on macrophage number and infiltration during rat skeletal muscle regeneration.

    Science.gov (United States)

    Fujita, Naoto; Ono, Miharu; Tomioka, Tomoka; Deie, Masataka

    2014-01-01

    Use of mild hyperbaric oxygen less than 2 atmospheres absolute (2026.54 hPa) with normal air is emerging as a common complementary treatment for severe muscle injury. Although hyperbaric oxygen at over 2 atmospheres absolute with 100% O2 promotes healing of skeletal muscle injury, it is not clear whether mild hyperbaric oxygen is equally effective. The purpose of the present study was to investigate the impact of hyperbaric oxygen at 1.25 atmospheres absolute (1266.59 hPa) with normal air on muscle regeneration. The tibialis anterior muscle of male Wistar rats was injured by injection of bupivacaine hydrochloride, and rats were randomly assigned to a hyperbaric oxygen experimental group or to a non-hyperbaric oxygen control group. Immediately after the injection, rats were exposed to hyperbaric oxygen, and the treatment was continued for 28 days. The cross-sectional area of centrally nucleated muscle fibers was significantly larger in rats exposed to hyperbaric oxygen than in controls 5 and 7 days after injury. The number of CD68- or CD68- and CD206-positive cells was significantly higher in rats exposed to hyperbaric oxygen than in controls 24 h after injury. Additionally, tumor necrosis factor-α and interleukin-10 mRNA expression levels were significantly higher in rats exposed to hyperbaric oxygen than in controls 24 h after injury. The number of Pax7- and MyoD- or MyoD- and myogenin-positive nuclei per mm2 and the expression levels of these proteins were significantly higher in rats exposed to hyperbaric oxygen than in controls 5 days after injury. These results suggest that mild hyperbaric oxygen promotes skeletal muscle regeneration in the early phase after injury, possibly due to reduced hypoxic conditions leading to accelerated macrophage infiltration and phenotype transition. In conclusion, mild hyperbaric oxygen less than 2 atmospheres absolute with normal air is an appropriate support therapy for severe muscle injuries.

  7. Hyperbaric oxygen upregulates cochlear constitutive nitric oxide synthase

    Directory of Open Access Journals (Sweden)

    Kao Ming-Ching

    2011-02-01

    Full Text Available Abstract Background Hyperbaric oxygen therapy (HBOT is a known adjuvant for treating ischemia-related inner ear diseases. Controversies still exist in the role of HBOT in cochlear diseases. Few studies to date have investigated the cellular changes that occur in inner ears after HBOT. Nitric oxide, which is synthesized by nitric oxide synthase (NOS, is an important signaling molecule in cochlear physiology and pathology. Here we investigated the effects of hyperbaric oxygen on eardrum morphology, cochlear function and expression of NOS isoforms in cochlear substructures after repetitive HBOT in guinea pigs. Results Minor changes in the eardrum were observed after repetitive HBOT, which did not result in a significant hearing threshold shift by tone burst auditory brainstem responses. A differential effect of HBOT on the expression of NOS isoforms was identified. Upregulation of constitutive NOS (nNOS and eNOS was found in the substructures of the cochlea after HBOT, but inducible NOS was not found in normal or HBOT animals, as shown by immunohistochemistry. There was no obvious DNA fragmentation present in this HBOT animal model. Conclusions The present evidence indicates that the customary HBOT protocol may increase constitutive NOS expression but such upregulation did not cause cell death in the treated cochlea. The cochlear morphology and auditory function are consequently not changed through the protocol.

  8. A prospective, randomized, controlled study of hyperbaric oxygen therapy: effects on healing and oxidative stress of ulcer tissue in patients with a diabetic foot ulcer.

    Science.gov (United States)

    Ma, Le; Li, Pingsong; Shi, Zehong; Hou, Tuanjie; Chen, Xiao; Du, Jin

    2013-03-01

    Although hyperbaric oxygen (HBO) therapy has been reported to help heal chronic foot ulcers in patients with diabetes mellitus (DM), production of HBO-related oxidative stress is a concern. To assess the therapeutic effect and oxidative stress of HBO, a 2-week, prospective, randomized, controlled clinical study was conducted from January 1, 2010 to January1, 2012 among 36 consecutively admitted patients with diabetic foot ulcers (DFU). Average patient age was 60.08 ± 5.97 years and average DM duration was 16.4 ± 11.3 years; 86.1% had type 2 DM, and 47.2% had Wagner grade-III foot ulcers. Patients randomized to the control group (n = 18) received standard care including offloading, wound debridement, and glucose control. HBO treatment group patients (n = 18) received standard care and twice-daily HBO sessions for 90 minutes at 2.5 atmospheres absolute (ATA) 5 days a week for 2 weeks. Transcutaneous oxygen pressure (TcPo2) at the edge of the ulcer and wound size were measured at baseline and after 7 and 14 days of treatment. Ulcer tissues were harvested on days 7 and 14 to determine oxidative stress by measuring malondialdehyde (MDA) and antioxidant enzyme (superoxide dismutase [SOD], catalase [CAT], and glutathione peroxidase [GPx]) levels. Compared to baseline, TcPo2 in the HBO group increased on day 7 (477.8 ± 118.2 mm Hg versus 37.06 ± 5.23 mm Hg, P Ulcer size reduction in the HBO group was greater than that of the control group (42.4% ± 20.0% versus 18.1% ± 6.5%, P ulcer tissue may offset this effect long-term. Until needed additional research has been conducted, prolonged and/or inappropriate HBO treatment should be avoided.

  9. Sudden Hearing Loss Treated With Hyperbaric Oxygen (HBO – Case Study

    Directory of Open Access Journals (Sweden)

    Fal Michał

    2015-06-01

    Full Text Available The article presents a case study of a 32-year-old patient admitted to the Mazowia Hyperbaric Therapy Centre due to a sudden loss of hearing. In an interview the patient reported an abrupt hearing deterioration in his right ear and the feeling of congestion in the left ear with bilateral tinnitus present for over 2 months. The patient was qualified to undergo hyperbaric oxygen therapy (HBO. After 15 treatment sessions in a pressure chamber a noticeable improvement of hearing in his right-ear was noted (proved by pure tone audiometry and subjective hearing upswing in his left ear.

  10. Cerebral arterial gas embolism following diagnostic bronchoscopy: delayed treatment with hyperbaric oxygen.

    Science.gov (United States)

    Wherrett, Chris G; Mehran, Reza J; Beaulieu, Marc-Andre

    2002-01-01

    To describe a clinical scenario consistent with the diagnosis of cerebral arterial gas embolism (CAGE) acquired during an outpatient bronchoscopy. Our discussion explores the mechanisms and diagnosis of CAGE and the role of hyperbaric oxygen therapy. A diagnostic bronchoscopy was performed on a 70-yr-old man who had had a lobectomy for bronchogenic carcinoma three months earlier. During the direct insufflation of oxygen into the right middle lobe bronchus, the patient became unresponsive and developed subcutaneous emphysema. Immediately, an endotracheal tube and bilateral chest tubes were placed with resultant improvement in his oxygen saturation. However, he remained unresponsive with extensor and flexor responses to pain. Later, in the intensive care unit, he exhibited seizure activity requiring anticonvulsant therapy. Sedation was utilized only briefly to facilitate controlled ventilation. Investigations revealed a negative computerized tomography (CT) scan of the head, a normal cerebral spinal fluid examination, a CT chest that showed evidence of barotrauma, and an abnormal electroencephalogram. Fifty-two hours after the event, he was treated for presumed CAGE with hyperbaric oxygen using a modified United States Navy Table 6. Twelve hours later he had regained consciousness and was extubated. He underwent two more hyperbaric treatments and was discharged from hospital one week after the event, fully recovered. A patient with presumed CAGE made a complete recovery following treatment with hyperbaric oxygen therapy even though it was initiated after a significant time delay.

  11. Effect of hyperbaric oxygen on MMP9/2 expression and motor function in rats with spinal cord injury.

    Science.gov (United States)

    Hou, Ying-Nuo; Ding, Wen-Yuan; Shen, Yong; Yang, Da-Long; Wang, Lin-Feng; Zhang, Peng

    2015-01-01

    To study the effect of hyperbaric oxygen intervention on the microenvironment of nerve regeneration after spinal cord injury modeling and to explore the possible mechanism of nerve regeneration and functional recovery in rats with spinal cord injury. In 98 adult female SD rats, 90 successful models were obtained, which were divided into sham group, spinal cord injury group and hyperbaric oxygen group using randomized block method, 30/group. Spinal cord injury rat model was established in accordance with the modified Allen method. Motor function was assessed at the time points of before modeling, one day, three days, one week, two weeks, three weeks and four weeks after modeling respectively by BBB rating, inclined plane test and improved Tarlov score. At 3 days after modeling, apoptosis of neuronal cells in spinal cord injury region in experimental group was detected by TUNEL method; gene and protein expression of MMP9/2 in spinal cord injury and surrounding tissues was detected by RT-PCR and Western blot assay. At 4 weeks after modeling, histopathological morphological changes in spinal cord injury were observed by HE staining; fluorogold retrograde tracing was used to observe the regeneration and distribution of spinal cord nerve fibers and axon regeneration was observed by TEM. The three motor function scores in hyperbaric oxygen group at each time point after two weeks of treatment were significantly increased compared with spinal cord injury group (P hyperbaric oxygen group were significantly lower than those in spinal cord injury group (P hyperbaric oxygen group was significantly lower (P hyperbaric oxygen group and spinal cord injury group in order; the differences among the groups were statistically significant (P hyperbaric oxygen group; unmyelinated and myelinated nerve fibers in hyperbaric oxygen group were more than those in spinal cord injury group. Hyperbaric oxygen therapy played a protective effect on spinal cord injury through reducing apoptosis of

  12. Combined administration of hyperbaric oxygen and hydroxocobalamin improves cerebral metabolism after acute cyanide poisoning in rats

    DEFF Research Database (Denmark)

    Hansen, M B; Olsen, Niels Vidiendal; Hyldegaard, O

    2013-01-01

    Hyperbaric oxygen therapy (HBOT) or intravenous hydroxocobalamin (OHCob) both abolish cyanide (CN)-induced surges in interstitial brain lactate and glucose concentrations. HBOT has been shown to induce a delayed increase in whole blood CN concentrations, whereas OHCob may act as an intravascular CN...

  13. To compare the effects of multiple sessions of Hyperbaric Oxygen Therapy in neurological improvement in head injury patients: A prospective randomized trial

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    Amlendu Yadav

    2015-01-01

    Full Text Available Introduction: Hyperbaric oxygen therapy (HBOT is used to improve functional outcome following brain injuries. Different number of sessions of HBOT have been reported but the frequency of HBOT sessions in head injured patients has not been standardized. We planned this prospective randomized study with an aim to compare the neurological effects of 10, 20 and 30 sessions of HBOT in the head injured patients. Materials and Methods: After review board approval, this study was conducted in 60 head injury patients with Glasgow Coma Scale (GCS score ≤ 9. All patients were resuscitated, stabilized and received neurological care according to institutional protocol. Patients were randomly allotted to-Group H10 (n-20-which received 10 sittings of HBOT, Group H20 (n-20-which received 20 sittings of HBOT, Group H30 (n-30-which received 30 sittings of HBOT. GCS score was recorded after every 10 sittings and at 30 days from initiation of HBOT. Improvement Global rating and Glasgow outcome scale (GOS were recorded after 30 days. Results: The maximum improvement in GCS scores was seen in group H30. The difference in the average improvement global rating scale was significant between group H10 and group H20, between group H10 and group H30 but was comparable between groups H20 and H30. The GOS was better after 30 sessions as compared to 10 sessions. Patients of all groups showed improvement in spasticity but group H30 showed a maximum improvement. Conclusion: A minimum of 30 HBOT sessions should be considered in head injury patients to show improvement with HBOT. Progressive improvement in GCS scores, GOS, spasticity, mood swings was better seen with increased number of HBOT sessions.

  14. Hyperbaric oxygenation accelerates prosthetic rehabilitation of lower limb amputees.

    Science.gov (United States)

    Igor, Simanic; Mirko, Teofilovski; Dalibor, Paspalj; Milutin, Radotic; Dusica, Djordjevic; Vladimir, Zivkovic; Vladimir, Jakovljevic

    2013-01-01

    The purpose of the study was to assess the effects of hyperbaric oxygen (HBO2) therapy on prosthetic rehabilitation of patients with unilateral lower limb amputation. Narang's scale,the Locomotor Capabilities Index and the two-minute walk test were used to assess functional abilities of amputees on the admission and on discharge from hospital. We also kept records of some clinical parameters whose improvement enables better mobility of patients: thigh and lower leg girth, strength of amputation stump, existence of amputation stump contracture, existence of some other complications on amputation stump, blood oxygenation and pulse palpation. Our results show that hyperbaric oxygenation accelerates prosthetic rehabilitation of lower limb amputees. HBO2-treated patients were discharged from the hospital faster than the controls (hospitalized for 133.2 +/- 54.87 days vs. 158.36 +/- 53.05 days), they had improved arterial Hb saturation (97.40 +/- 3.51% vs. 94.74 +/- 3.28 %) and pulse palpability (pulse palpable in 27 vs. 18 subjects), less complications of the amputation stump (complications present in 24 vs. 30 subjects), greater healthy leg thigh girth (50.75 +/- 3.96 cm vs. 48.90 +/- 2.59 cm), stronger amputation stump (mark 3.90 +/- 0.54 vs. 3.33 +/- 0.47) and better functional abilities as measured by adapted Narang's scale (category 3.43 +/- 1.30 vs. 4.10 +/- 1.12) and locomotor capabilities index (score 38.06 +/- 10.90 vs. 33.16 +/- 8.80). These findings highlight the increasing validity of this procedure after limb amputation, which should be confirmed by further research in multicenter studies involving a larger number of respondents.

  15. Hyperbaric oxygen associated therapy on 398 youth myocardial ischemia%高压氧辅助治疗青年人心肌缺血398例

    Institute of Scientific and Technical Information of China (English)

    袁宝先; 王国枝

    2002-01-01

    @@ Background: Main causes of youth myocardial ischemia are smoking and hypercholesterolemia, which leads to disorder of collateral circulation, increase of cardiac accidence and coronary atherosclerosis. Hypoxia is easy to happen because thick of sclerotic vessels wall nearly reaches the maximal diffuse distance in this tissue. CO in cigarettes can lead to hypoxia and myocardial ischemia. After use of hyperbaric oxygen, blood fat decrease, incidence of coronary atherosclerosis decreases apparently. And it promotes myocardial hypoxia and metabolism, increases myocardial contraction and promotes heart function, thereby decrease incidence of angina, myocardial infarction and sudden death.

  16. Hyperbaric oxygen treatment in autism spectrum disorders

    Directory of Open Access Journals (Sweden)

    Rossignol Daniel A

    2012-06-01

    Full Text Available Abstract Traditionally, hyperbaric oxygen treatment (HBOT is indicated in several clinical disorders include decompression sickness, healing of problem wounds and arterial gas embolism. However, some investigators have used HBOT to treat individuals with autism spectrum disorders (ASD. A number of individuals with ASD possess certain physiological abnormalities that HBOT might ameliorate, including cerebral hypoperfusion, inflammation, mitochondrial dysfunction and oxidative stress. Studies of children with ASD have found positive changes in physiology and/or behavior from HBOT. For example, several studies have reported that HBOT improved cerebral perfusion, decreased markers of inflammation and did not worsen oxidative stress markers in children with ASD. Most studies of HBOT in children with ASD examined changes in behaviors and reported improvements in several behavioral domains although many of these studies were not controlled. Although the two trials employing a control group reported conflicting results, a recent systematic review noted several important distinctions between these trials. In the reviewed studies, HBOT had minimal adverse effects and was well tolerated. Studies which used a higher frequency of HBOT sessions (e.g., 10 sessions per week as opposed to 5 sessions per week generally reported more significant improvements. Many of the studies had limitations which may have contributed to inconsistent findings across studies, including the use of many different standardized and non-standardized instruments, making it difficult to directly compare the results of studies or to know if there are specific areas of behavior in which HBOT is most effective. The variability in results between studies could also have been due to certain subgroups of children with ASD responding differently to HBOT. Most of the reviewed studies relied on changes in behavioral measurements, which may lag behind physiological changes. Additional studies

  17. The impact of hyperbaric oxygen therapy on serological values of vascular endothelial growth factor (VEGF and basic fibroblast growth factor (bFGF

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    Ziebura Thomas

    2010-12-01

    Full Text Available Abstract Background Hyperbaric oxygen (HBO therapy is an effective adjunct treatment for ischemic disorders such as chronic infection or chronic wounds. It combines hyperoxic effects with the stimulating potential of post-therapeutic reactive hypoxia. As its crucial effects, stimulation of fibroblast growth, induction of collagen synthesis and the initiation of angiogenesis are discussed. Angiogenesis is a multistage process resulting in the growth of blood vessels. It includes degradation of extracellular matrix, proliferation and migration of different cell populations and finally formation of new vessel structures. This complex chain of procedures is orchestrated by different cytokines and growth factors. Crucial mediators of angiogenesis are basic fibroblast growth factor (bFGF and vascular endothelial growth factor (VEGF; their in-vivo function is still not fully understood. Methods Forty-three patients suffering from sudden sensorineural hearing loss or tinnitus were treated with HBO. The therapy included 10 sessions of 90 minutes each, one session a day. Serological levels of bFGF and VEGF were assessed by enzyme-linked immunosorbent assays performed according to the manufacturer's instructions on day 1, 2, 5 and 10 of HBO therapy and were compared to mean values of the control group, related to the patient's age and sex, and their development observed over the ten days of HBO. Results There was no sex- or age dependency of bFGF observed in the present study, whereas under HBO our results showed a significant mitigation of the bFGF concentration. In the present data, there was no connection between the VEGF concentration and the patients' ages. Women showed significantly higher levels of VEGF. There was no significant change of VEGF concentration or the VEGF/bFGF ratio during HBO. All scored results varied within the range of standard values as described in the current literature. Conclusions A significant effect of HBO on serum

  18. Delayed response of the retina after hyperbaric oxygen exposure

    DEFF Research Database (Denmark)

    Kofoed, Peter Kristian; Hasler, Pascal W; Sander, Birgit

    2011-01-01

    Purpose: To examine retinal electrophysiological function and retinal thickness in healthy eyes before and after hyperbaric oxygen (HBO) exposure. Methods: The healthy eye in each of six subjects who underwent experimental HBO treatment for branch retinal vein occlusion in the fellow eye was exam......Purpose: To examine retinal electrophysiological function and retinal thickness in healthy eyes before and after hyperbaric oxygen (HBO) exposure. Methods: The healthy eye in each of six subjects who underwent experimental HBO treatment for branch retinal vein occlusion in the fellow eye...

  19. 高压氧辅助治疗促进尿道下裂患儿术后伤口的愈合%Hyperbaric Oxygen Auxiliary Therapy Ameliorating Postoperative Dermal Wound Healing of Hypospadias

    Institute of Scientific and Technical Information of China (English)

    雷伟; 李爽; 王军; 戴世希

    2011-01-01

    目的 探讨高压氧辅助治疗对尿道下裂(后型)患儿术后促进转移包皮皮瓣存活及预防尿瘘的作用.方法 选取2006年1月-2010年12月在本院住院的年龄1~4岁的尿道下裂后型术后(Dukett尿道成型术)患儿,在常规使用相同抗生素治疗基础上,200例尿道下裂术后高压氧治疗患儿为高压氧治疗组.高压氧治疗组术后第2天开始高压氧治疗,疗程5 d,治疗压力2.3绝对压(ATA),加压20 min,面罩吸入纯氧40 min(舱内空气氧体积分数<250 mL·L-1),间隔吸入空气10 min,再吸纯氧40 min,减压33 min.每天1次,每次治疗143 min.选取200例术后未行高压氧治疗的患儿作为对照组.术后第2天、第7天行动脉血气分析,同时观察患儿转移包皮皮瓣存活情况及尿瘘发生率.采用指标包括手指末梢血氧分压[pa(O2)]、氧饱和度[Sa(O2)]、转移包皮皮瓣存活情况和尿瘘发生率.结果 高压氧治疗组术后第2天、第7天pa(O2)分别为(93.33±2.50)mmHg(1 mmHg=0.133 kPa)、(95.22±1.77)mmHg,Sa(O2)分别为(94.86±1.61)%、(96.08±1.60)%,均高于对照组(Pa<0.05).高压氧治疗组转移包皮皮瓣显著存活157例(显著有效存活率78.5%),明显高于对照组(显著有效存活136例,存活率为68.0%)(P<0.05);且尿瘘的发生率(14.0%)明显低于对照组(22.5%)(P<0.05).结论 高压氧治疗可增加机体血氧含量、提高pa(O2),明显改善缺血、缺氧组织的血供,增强微循环功能,从而促进尿道下裂术后转移皮瓣的存活,降低尿瘘发生.%Objective To explore the effect of hyperbaric oxygen auxiliary therapy on postoperative hypospadias ( post type) by promoting survival of transferred foreskin flap and preventing of urinary fistula. Methods Selecting hypospadias ( post type) children ( Dukett urethra angioplasty) whose age were 1 -4 years in Wuhan Children's Hospital from Jan. 2006 to Dec. 2010,200 cases treated with hyperbaric oxygen auxiliary therapy after surgery were the group of

  20. Clinical study of early hyperbaric oxygen therapy for cerebral resuscitation%早期应用高压氧进行脑复苏的临床研究

    Institute of Scientific and Technical Information of China (English)

    潘树义; 孟祥恩; 李铭鑫; 张禹; 吕艳; 杨晨; 张良; 刘文成

    2011-01-01

    Objective To observe the effect of early hyperbaric oxygen (HBO) therapy on cerebral resuscitation and to provide good evidence and method for the treatment of cerebral resuscitation.Methods The patients responded to cardiac pulmonary resuscitation (CPR) were divided into 2 groups,the early HBO group( within one week of onset) and the delayed HBO group (after 1 week of onset).All the patients were given routine medicinal treatment coupled with HBO therapy.The exposure pressure of HBO and the course of treatment were all the same,only the time point of HBO intervention was different.Evaluation was made by using "the Revised 2001 PVS Criteria for Diagnosis and Treatment" ( the Nanjing Criteria).Consciousness of the patients was evaluated both before HBO therapy and 6 months after onset.Results Of the 18 patients who received early HBO therapy,4 patients recovered and returned to normal life (effective),5 patients became fully conscious,but with minor disability (effective),and 9 patients became vegetable (ineffective),with a total effective rate of 50.0%.Of the 53 patients with delayed HBO therapy,9 patients recovered and returned to normal life (effective),15 patients became fully conscious,but with minor disability (effective),and 29 patients became vegetable (ineffective),with a total effective rate of 45.3%.No significant differences could be seen in effective rates between the 2 groups (P >0.05).However,statistical significance could be noted,when effective rates of the 2 groups were compared with those presented in domestic and international reports (2%-10% ) ( P < 0.05 ).Conclusions In-time HBO therapy could improve prognosis of some patients following cardiac resuscitation,protect neural cells,and improve the intelligence of patients,however,early and ultra-early HBO therapy could not increase the effective rate of cerebral resuscitation.%目的 观察早期高压氧( hyperbaric oxygen,HBO)治疗对脑复苏成功率的影响,为临床脑复苏

  1. Changes in serum cellular adhesion molecule and matrix metalloproteinase-9 levels in patients with cerebral infarction following hyperbaric oxygen therapy A case and intergroup control study

    Institute of Scientific and Technical Information of China (English)

    Renliang Zhao; Chunxia Wang; Yongjun Wang

    2008-01-01

    BACKGROUND: Animal studies have confirmed that hyperbaric oxygen (HBO) therapy can reduce matrix metalloproteinase activity and blood brain barrier permeability, thereby exhibiting neuroprotective effects. However, at present, consensus does not exist in terms of its clinical efficacy. OBJECTIVE: To validate the significance of changes in serum cellular adhesion molecule and MMP-9 levels in patients with cerebral infarction following HBO therapy. DESIGN, TIME AND SETTING: This randomized, controlled, neurobiochemical study was performed at the Department of Neurology, Affiliated Hospital of Qingdao University Medical College between December 2002 and March 2006. PARTICIPANTS: A total of 112 patients with acute cerebral infarction of internal carotid artery, comprising 64 males and 48 females, averaging (67 ± 11) years, were recruited and randomized to a HBO group (n = 50) and a routine treatment group (n = 62). An additional 30 gender- and age-matched normal subjects, consisting of 17 males and 13 females, averaging (63 ± 9) years, were enrolled as control subjects. METHODS: The routine treatment group received routine drug treatment and rehabilitation exercise. HBO treatment was additionally performed in the HBO group, once a day, for a total of 10 days. MAIN OUTCOME MEASURES: Serum levels of soluble intercellular adhesion molecule, soluble vascular cell adhesion molecule, soluble E-selectin, and matrix metalloproteinase-9 were detected by enzyme linked immunosorbent assay. RESULTS: Upon admission, serum levels of soluble intercellular adhesion molecule, soluble vascular cell adhesion molecule, soluble E-selectin, and matrix metalloproteinase-9 were significantly increased in patients with cerebral infarction, compared with control subjects (P < 0.01). Following HBO and routine treatments, serum levels of the above-mentioned indices were significantly reduced in the HBO and routine treatment groups (P < 0.01). Moreover, greater efficacy was observed in the HBO

  2. The effect of hyperbaric oxygenation on the viability of human fat injected into nude mice.

    Science.gov (United States)

    Shoshani, O; Shupak, A; Ullmann, Y; Ramon, Y; Gilhar, A; Kehat, I; Peled, I J

    2000-11-01

    Autologous free-fat injection for the correction of soft-tissue defects has become a common procedure in plastic surgery. The main shortcoming of this method for achieving permanent soft-tissue augmentation is the partial absorption of the injected fat, an occurrence that leads to the need for both overcorrection and repeated fat reinjection. Improving the oxygenation of the injected fat has been suggested as a means of helping to overcome the initial critical phase that occurs postinjection (when the fat cells are nourished by osmosis), increasing phagocyte activity, accelerating fibroblast activity and collagen formation, and enhancing angiogenesis. In addition, the hyperbaric oxygen-mediated decrement in endothelial leukocyte adhesion will decrease cytokine release, thereby reducing edema and inflammatory responses. The purpose of the present study was to examine the effect of hyperbaric oxygenation on improving the viability of injected fat. Adipose tissue obtained from human breasts by suction-assisted lipectomy was injected into the subcuticular nuchal region in nude mice. The mice were then exposed to daily hyperbaric oxygen treatments, breathing 100% oxygen at 2 atmospheres absolute (ATA) for 90 minutes. The duration of the administered hyperbaric oxygen therapy was 5, 10, or 15 days, according to the study group. Mice exposed to normobaric air alone served as the control group, and each group included 10 animals. The rats were killed 15 weeks after fat injection. The grafts were dissected out, weight and volume were measured, and histologic evaluation was performed. In all of the study groups, at least part of the injected fat survived, giving the desired clinical outcome. No significant differences could be found between the groups regarding fat weight and volume. Histopathologic examination of the dissected grafts demonstrated a significantly better integrity of the fat tissue in the group that received hyperbaric oxygen for 5 days (p = 0.047). This

  3. Evaluation of Hyperbaric Oxygen Therapy in the Treatment of Spinal Cord Injury Using the Rabbit Spinal Stroke Model

    Science.gov (United States)

    1990-11-30

    transition metals are dislocated from their protein bound sites and are free to catalyze single electron reduction of oxygen, various enzyme systems known...878. 12. Jamieson D, Chance B, Cadenas E, Boveris A. The relation of free radical production to hyperoxia. Ann Rev Physiol 1986;48:703-719. 13. Kontos...hypoxanthine transport and xanthine oxidase activity in brain capillaries. J Neurochem 1985;44:574-583. 20. Povlishock JT, Wei EP, Kontos HA. Histochemical

  4. MRI of radiation myelitis: a report of a case treated with hyperbaric oxygen

    Energy Technology Data Exchange (ETDEWEB)

    Calabro, F. [Neuroradiology Section T. M. A. Clinica Villa Salus Genoa, Via Montallegro, 48, I-16145 Genoa (Italy); Jinkins, J.R. [Neuroradiology Section, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, Texas 78229-3900 (United States)

    2000-07-01

    Radiation therapy is commonly applied as a primary or adjuvant therapy for malignancies. One of the major complications following radiation therapy is the necrosis of the otherwise normal surrounding soft tissues and/or bone. Post-radiation myelopathy rarely occurs when the spinal cord is included within the radiation field, in cases of high total radiation doses or for high radiation doses per fractionation. Up until the present, no tolerance dose for the spinal cord has accurately been defined and no treatment has proved satisfactory. Hyperbaric oxygen therapy is already currently used as adjuvant treatment for osteoradionecrosis and for radionecrosis of soft tissues with satisfactory results, whereas results for the treatment of post-attinic myelitis were contradictory. The aim of our report is to describe a case of radiation myelitis with a progressive improvement in the clinico-radiologic picture following hyperbaric oxygen treatment. (orig.)

  5. Hyperbaric oxygen-A new horizon in treating cyclophosphamide-induced hemorrhagic cystitis

    Directory of Open Access Journals (Sweden)

    S Ajith Kumar

    2011-01-01

    Full Text Available Hemorrhagic cystitis consists of acute or insidious diffuse bleeding from the bladder mucosa. It can be caused by radiation, drugs, autoimmune diseases, viral and bacterial infections, etc. Hemorrhagic cystitis is a well-recognized complication of cyclophosphamide therapy and it can be potentially fatal. We discuss two cases of cyclophosphamide-induced hemorrhagic cystitis where outcome of conventional management was not satisfactory and a novel therapy using hyperbaric oxygen was used. Hyperbaric oxygen therapy (HBOT reduces inflammation, stimulates neoangiogenesis, maintains tissue oxygenation and heals tissue hypoxia and radio necrosis. Patients received 100% oxygen in a hyperbaric chamber at 2.5 atmosphere absolute (ATA for 90 minutes, 5 days a week. One patient was given 36 sessions and the other was given 19 sessions of HBOT. HBOT resulted in complete cessation of bleeding; no side effect was noted during the course of therapy. There was no relapse after 12 months of cessation of treatment. In future, this form of therapy can offer a safe alternative in the treatment of cyclophosphamide-induced hemorrhagic cystitis.

  6. Reduction of Ischemic and Oxidative Damage to the Hypothalamus by Hyperbaric Oxygen in Heatstroke Mice

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    Po-An Tai

    2010-01-01

    Full Text Available The aims of the present paper were to ascertain whether the heat-induced ischemia and oxidative damage to the hypothalamus and lethality in mice could be ameliorated by hyperbaric oxygen therapy. When normobaric air-treated mice underwent heat treatment, the fractional survival and core temperature at 4 hours after heat stress were found to be 0 of 12 and 34∘C±0.3∘C, respectively. In hyperbaric oxygen-treated mice, when exposed to the same treatment, both fractional survival and core temperature values were significantly increased to new values of 12/12 and 37.3∘C±0.3∘C, respectively. Compared to normobaric air-treated heatstroke mice, hyperbaric oxygen-treated mice displayed lower hypothalamic values of cellular ischemia and damage markers, prooxidant enzymes, proinflammatory cytokines, inducible nitric oxide synthase-dependent nitric oxide, and neuronal damage score. The data indicate that hyperbaric oxygen may improve outcomes of heatstroke by normalization of hypothalamic and thermoregulatory function in mice.

  7. Hyperbaric oxygen therapy for promoting the intellectual rehabilitation of infants with severe hypoxic-ischemic encephalopathy A 5-year follow-up

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    BACKGROUND: It has been reported that early intervention of hyperbaric oxygen (HBO) can promote the intellectual rehabilitation of infants with severe hypoxic-ischemic encephalopathy (HIE) and can prevent mental retardation recently. However, the prior observations on the therapeutic effect almost were short-term.How about the observations on prospective efficacy and the following up on systematic intelligence test? OBJECTIVE: To investigate the short-term and long-term effects of HBO therapy on the promotion of the intellectual rehabilitation in infants with severe HIE.DESIGN: A comparative observation.SETTING: Department of Pediatrics, Affiliated Hospital, Qingdao University Medical College.PARTICIPANTS: Forty-seven infants with severe HIE (35 males and 12 females) were treated with HBO in the Department of Pediatrics, the Affiliated Hospital of the Medical College of Qingdao University from October 1996 to July 1999. All of them were consistent with the diagnostic criteria and clinical grading on severe HIE which were designed by Chinese Medical Association pediatrics committee neonate group in Hangzhou, October, 1996. Informed contents were obtained from the relatives of all the infants.METHODS: ① Grouping: The infants were randomly divided into two groups according to the order of admission, those of odd numbers were HBO group (n =24) and those of even numbers were control group(n =23). All the infants were treated with routine therapy for 3 months, in addition to HBO therapy in the HBO group, once a day for 4 courses of 10 days with the interval of 10 - 15 days since 8 to 10 days after birth. HBO chamber produced by the 701 Institute of China Ship Industry Company was used, and the therapy pressure was 0.14 - 0.16 Mpa, and the time of compression and decompression were both 15 minutes while voltage-stabilizing was 30 minutes. ② In order to evaluate the short-term and long-term effects of HBO on intellectual rehabilitation in infants with HIE, neonatal

  8. Oxygen Therapy

    Science.gov (United States)

    Oxygen therapy is a treatment that provides you with extra oxygen. Oxygen is a gas that your body needs to function. Normally, your lungs absorb oxygen from the air you breathe. But some conditions ...

  9. The clinical application of hyperbaric oxygen therapy for brain trauma cognitive disorder%高压氧治疗脑外伤认知障碍的临床应用

    Institute of Scientific and Technical Information of China (English)

    徐春江; 韩扬

    2013-01-01

    The cognitive disorder is common in patients with traumatic brain injury,one of the pathogenesis of cognitive disorde after brain injury is very complex and in close contact,cognitive disorde assessment method is mainly neuropsychological scale,MMSE is one of the most influential cognitive screening tool that is widely used at home and abroad.At present in the treatment of cognitive disorde,traumatic brain injury rehabilitation training is regarded as a routine treatment,and should be performed as early as possible.Based on the cognitive rehabilitation of computer-aided remote rehabilitation abroad has developed rapidly,the Chinese medicine,acupuncture,drug therapy,hyperbaric oxygen therapy and the integrated use of various treatment methods,is currently the head trauma treatment commonly used cognitive disorde.Hyperbaric oxygen therapy of brain trauma,less experimental studies of cognitive disorde.Hyperbaric oxygen therapy of brain trauma cognitive disorde is mainly the mechanism of hyperbaric oxygen on cerebral protection and repair of damage function.Brain injury rehabilitation of cognitive disorder,need to be adopted,including conventional drugs,rehabilitation training,hyperbaric oxygen therapy,family training,distance and other rehabilitation method,the overall plan,the clinical curative effect is expected to increase significantly.%认知功能障碍是脑外伤患者常见的表现之一,脑外伤后认知障碍的发病机制十分复杂且密切联系,认知障碍的的评定方法主要是神经心理量表,精神状态简易速检表(MMSE)是最具影响力的认知功能筛查工具,在国内外被广泛应用.目前对脑外伤认知障碍的治疗中,康复训练被认为是常规的治疗手段,并且被认为应及早进行.基于电脑辅助的认知康复即远程康复在国外发展迅速,中药、针灸、药物治疗、高压氧治疗及各种治疗方法的综合运用,是目前脑外伤认知障碍的常用治疗手段.高压氧治疗脑外

  10. Effect of hyperbaric oxygen therapy in rats with subtotal splenectomy preserving the inferior pole Efeito da oxigenoterapia hiperbárica em ratos submetidos à esplenectomia subtotal com preservação do polo inferior

    Directory of Open Access Journals (Sweden)

    Marcela Souza Lima Paulo

    2011-06-01

    Full Text Available PURPOSE: To evaluate the effect of hyperbaric oxygen therapy on the survival and weight of rats submitted to subtotal splenectomy and on the viability and growth of the inferior pole. METHODS: Forty Wistar rats underwent subtotal splenectomy with preservation of the inferior pole and distributed into two groups: Group A (n=20 - not treated with hyperbaric oxygen, Group B (n=20 - treated with hyperbaric oxygen. These groups were divided into two subgroups of 10 animals each, according to the time of euthanasia, 15th and 45th days. The survival and weight of the animals were recorded. The inferior pole was measured, weighed and morphologically analyzed. RESULTS: All animals survived. The weight of the animals increased in all subgroups, but decreased on the 10th day in the subgroups treated with hyperbaric oxygen (pOBJETIVO: Avaliar o efeito da oxigenoterapia hiperbárica na sobrevida e peso de ratos submetidos à esplenectomia subtotal e na viabilidade e crescimento do polo inferior. MÉTODOS: Quarenta ratos Wistar foram submetidos à esplenectomia subtotal com preservação do polo inferior e distribuídos em dois grupos: A (n=20 v - não tratados com oxigênio hiperbárico, B (n=20 - tratados. Esses grupos foram divididos em dois subgrupos de 10 animais cada, de acordo com a época de eutanásia: 15º e 45º dias. A sobrevida e peso dos animais foram anotadas. O pólo inferior foi medido, pesado e analisado morfologicamente. RESULTADOS: Todos os animais sobreviveram. O peso aumentou em todos os subgrupos, porém diminuiu no 10º dia nos subgrupos tratados com oxigênio hiperbárico (p<0,001. A viabilidade do polo inferior foi mais evidente nos animais tratados no 15º dia, porém não diferiu no 45º dia. O crescimento do polo inferior não ocorreu no 15º e sim no 45º dia pós-operatório, nos animais não tratados (p<0,01 e tratados (p<0,05. O aumento celular e vascular nos animais tratados foi mais significativo do que nos animais n

  11. Amputation predictors in diabetic foot ulcers treated with hyperbaric oxygen.

    Science.gov (United States)

    Kaplan, S T; Hemsinli, D; Kaplan, S; Arslan, A

    2017-07-02

    Although hyperbaric oxygen therapy (HBOT) has long been used for diabetic foot ulcers (DFUs), its effectiveness is still controversial. The aim of this study was to investigate the efficacy of HBOT in the management of DFUs and identify amputation predictors. Patients with chronic DFUs (Wanger grade 2-5) were included in the study, which took place between January 2010 and December 2012. HBOT, 100% oxygen, 2.4 atmosphere absolute (ATA) for 120 minutes, was administered to all patients in addition to standard treatment. DFUs were monitored for at least 3 years, or until healing or amputation occurred. Patients with a total of 146 chronic DFUswere recruited. Complete healing (69.6%) and significant improvement (17.9%) was observed in 87.5% of the patients. The cases with no improvement resulted in amputation (minor amputation: 15.0%; major amputation: 8.2%). The duration of diabetes (p=0.037), new wound formation (p=0.045), C-reactive protein (p=0.001) and Wagner grade (p=0.0001) were correlated with amputation in multiple regression analysis. Mortality was higher in the amputation group than in the non-amputation group (47.1 % versus 21.4 %, p=0.007). The inclusion of HBOT with standard treatment and a multidisciplinary approach may be useful in the treatment of DFUs. We found the most important predictors of amputation to be Wagner grade and wound infection. Multicentre, prospective, randomised studies are needed to provide more evidence.

  12. 高压氧协同药物综合治疗急性亚硝酸盐中毒9例分析%Clinical Study of Hyperbaric Oxygen Combined Therapy for 9 Cases of Acute Poisoning by Nitrite

    Institute of Scientific and Technical Information of China (English)

    林琳; 钱培丽; 朱彩琴; 赵迎春

    2012-01-01

    目的 探讨0.25 MPa高压氧(HBO)协同药物综合治疗急性亚硝酸盐中毒的疗效,通过分析急性亚硝酸盐中毒的机制明确高压氧综合治疗的临床意义.方法 0.25 Mpa HBO协同清水洗胃催吐、药物(特效解毒剂亚甲蓝拮抗、维生素C注射液、葡萄糖补液)综合治疗9例中度急性亚硝酸盐中毒患者.根据患者病情,分别给予亚甲蓝40 mg或80mg静推,维生素C3.0~5.0g静滴,HBO 1次/d,疗程1~2次.结果 9例中度急性亚硝酸中毒患者全部治愈.结论 0.25 MPa HBO协同药物综合治疗中度急性亚硝酸盐中毒患者有效.临床上除正确应用亚甲蓝等药物外,对病情较严重者应尽早高压氧治疗.%Objective To study the effect of 0.25 MPa hyperbaric oxygen therapy combined drugs for acute poisoning by nitrite. Through analyzing the mechanism of acute poisoning by nitrite, it would identify clinical significance of hyperbaric oxygen combined therapy. Methods 9 cases of midrange acute poisoning by nitrite were treated with 0.25 MPa HBO combined gastric lavage and drug therapy (methylthioninium chloride, vitamin C, glucose). Methylthioninium chloride was effective antidote of acute poisoning by nitrite. According to the patients' condition,infusion methylthioninium chloride 40 mg or 80 mg and vitamin C 3.0 -5.0 g were given intravenous,and HBO once a day,one or two as a course of treatmeat. Results 9 cases of midrange acute poisoning by nitrite treating with hyperbaric oxygen combined therapy were cured. Conclusion HBO combined therapy for midrange acute poisoning by nitrite was effective. Midrange and severe patients of acute poisoning by nitrite should be treated with HBO in early stage of the disease.

  13. MRS联合DWI观察实验性兔颅脑爆震伤后高压氧的治疗作用%Hyperbaric oxygen therapy in rabbits after explosive brain injury: a MRS and DWI study

    Institute of Scientific and Technical Information of China (English)

    杨艳艳; 刘家传; 张永明; 孙文江; 汤宏; 黄振山; 李兵仓; 张良潮

    2011-01-01

    Objective To evaluate the role of magnetic resonance spectroscopy (MRS) and diffusion-weighted MRI (DWI) in detecting regional cerebral metabolic changes and changes of water molecular motion in rabbits after explosive brain injury at different time points of injury after being treated with hyperbaric oxygen therapy. Methods Ninety New Zealand white rabbits were divided into control group, trauma group and hyperbaric oxygen treatment group. The injured models in the later 2 groups were established using 600 mg TNT equivalent of paper detonators in the rabbit brain at the top of 6.5 cm vertical distance. Rabbits in the trauma group and hyperbaric oxygen treatment group were sub-divided into 1, 3, 7, 14 and 21 d treatment groups, respectively. The survival of these rabbits was observed at these time points. Hyperbaric oxygen treatments lasting for 1, 3, 7, 14 and 21 d were given to each hyperbaric oxygen treatment sub-groups, respectively. Performance under MRS was detected and dynamic changes of N-acetylaspartate (NAA)/creatine (Cr) ratio and NAA/choline(Cho)+Cr value were observed with MRS. DWI was employed to detect the dynamic changes of apparent diffusion coefficient (ADC) values. Results The NAA/Cr ratio in the trauma group markedly decreased right after the injury and slightly rose 7 d after the injury. Compared with that in the trauma group, the NAA/Cr ratio in the hyperbaric oxygen treatment group was significantly increased (P<0.05). The NAA/Cho+Cr value in the trauma group was markedly decreased right after the injury, while that in the hyperbaric oxygen treatment group was obviously increased as compared with that in the trauma group (P<0.05). ADC values in the region of interest of the trauma group was decreased after 1 d of treatment and gradually increased after 3 d of treatment; the ADC values in the hyperbaric oxygen treatment group was obviously higher than those in the trauma group (P<0.05). Conclusion Hyperbaric oxygen might improve the

  14. Avaliação funcional e histológica da oxigenoterapia hiperbárica em ratos com lesão medular Functional and histologic evaluation of hyperbaric oxygen therapy in rats with spinal cord injury

    Directory of Open Access Journals (Sweden)

    Paulo Eduardo de Carvalho Galvão

    2011-01-01

    Full Text Available OBJETIVOS: Avaliar a eficácia da aplicação da oxigenoterapia hiperbárica em ratos Wistar, com lesão medular contusa produzida por equipamento computadorizado para impacto por queda de peso, NYU Impactor. MÉTODOS: Avaliaram-se 17 ratos machos com peso variando de 265 a 426 g; realizaram-se impactos com peso de 10 g de uma altura pré-determinada de 12,5 mm ao nível da décima vértebra torácica, após realização de laminectomia prévia. Os ratos foram divididos aleatoriamente em grupo controle e grupo oxigênio hiperbárico. Este último, submetido à tratamento com oxigenoterapia em câmara hiperbárica, durante uma hora diária por um período de 30 dias. A avaliação da recuperação locomotora foi realizada no 2º, 9º, 16º, 23º e 30º dia pós-operatório, avaliados através de escala funcional e o sítio de lesão submetido à exame anatomopatológico. RESULTADOS: Demonstrou-se melhora da recuperação locomotora nos ratos tratados com oxigênio hiperbárico nas fases iniciais de avaliação mas no final da avaliação não havia diferença estatisticamente significante entre ambos grupos. O exame anatomopatológico comprovou as alterações estruturais da medula espinal nos dois grupos. CONCLUSÃO: A lesão medular leve provocada nos ratos evoluiu de maneira diferente no grupo da oxigenoterapia hiperbárica comparativamente ao grupo controle, na fase inicial.OBJECTIVE: To evaluate the effectiveness of the application of hyperbaric oxygen therapy in Wistar rats with spinal cord contusion produced using computerized equipment to create impact by a falling weight, NYU Impactor. METHODS: We evaluated 17 male rats with weights ranging from 265 to 426 g; impacts were performed with a weight of 10 g from a pre-determined height of 12.5 mm, at the tenth thoracic vertebra, after completion of prior laminectomy. The rats were randomly divided into a control group and a group treated with hyperbaric oxygen. The latter, was treated with

  15. Hyperbaric Oxygen Preconditioning Provides Preliminary Protection Against Doxorubicin Cardiotoxicity

    Science.gov (United States)

    Tezcan, Orhan; Karahan, Oguz; Alan, Mustafa; Ekinci, Cenap; Yavuz, Celal; Demirtas, Sinan; Ekinci, Aysun; Caliskan, Ahmet

    2017-01-01

    Background Doxorubicin (DOX) is generally recognized to have important cardiotoxic side effects. Studies are contradictory about the interaction between hyperbaric oxygen (HBO2) therapy and doxorubicin-induced cardiomyotoxicity. Recent data suggests that HBO2 therapy can lead to preconditioning of myocardium while generating oxidative stress. Herein we have investigated the effect of HBO2 therapy in a DOX-induced cardiomyocyte injury animal model. Methods Twenty-one rats were divided into three equal groups as follows: 1) Group 1 is a control group (without any intervention), used for evaluating the basal cardiac structures and determining the normal value of cardiacs and serum oxidative markers; 2) Group 2 is the doxorubicin group (single dose i.p. 20 mg/kg doxorubicin) for detecting the cardiotoxic and systemic effects of doxorubicin; 3) Group 3 is the doxorubicin and HBO2 group (100% oxygen at 2.5 atmospheric for 90 minutes, daily), for evaluating the effect of HBO2 in doxorubicin induced cardiotoxicity. At the end of the protocols, the hearts were harvested and blood samples (2 ml) were obtained. Results The doxorubicin treated animals (Group 2) had increased oxidative stress markers (both cardiac and serum) and severe cardiac injury as compared to the basal findings in the control group. Nevertheless, the highest cardiac oxidative stress index was detected in Group 3 (control vs. Group 3, p = 0.01). However, histological examination revealed that cardiac structures were well preserved in Group 3 when compared with Group 2. Conclusions Our results suggest that HBO2 preconditioning appears to be protective in the doxorubicin-induced cardiotoxicity model. Future studies are required to better elucidate the basis of this preconditioning effect of HBO2. PMID:28344418

  16. Hyperbaric oxygen in the treatment of radiation-induced optic neuropathy

    Energy Technology Data Exchange (ETDEWEB)

    Guy, J.; Schatz, N.J.

    1986-08-01

    Four patients with radiation-induced optic neuropathies were treated with hyperbaric oxygen. They had received radiation therapy for treatment of pituitary tumors, reticulum cell sarcoma, and meningioma. Two presented with amaurosis fugax before the onset of unilateral visual loss and began hyperbaria within 72 hours after development of unilateral optic neuropathy. Both had return of visual function to baseline levels. The others initiated treatment two to six weeks after visual loss occurred in the second eye and had no significant improvement of vision. Treatment consisted of daily administration of 100% oxygen under 2.8 atmospheres of pressure for 14-28 days. There were no medical complications of hyperbaria. While hyperbaric oxygen is effective in the treatment of radiation-induced optic neuropathy, it must be instituted within several days of deterioration in vision for restoration of baseline function.

  17. To the Mechanisms of Realization of the Adaptogenic Properties of Hyperbaric Oxygenation

    Directory of Open Access Journals (Sweden)

    A. D. Belyaevsky

    2005-01-01

    Full Text Available The impact of hyperbaric oxygenation (HBO on lipid peroxidation (LPO and the antioxidative system (AOS was studied in patients with isolated and combined brain injury, in those with female internal genital inflammatory diseases. HBO temporarily enhances endotoxicosis with its subsequent rapid decrease rate. The stimulation of LPO processes is directly related to the degree of underlying disorders caused by an injury or disease. The HBO therapy regimen should be individualized depending on the response of AOS.

  18. A multistep approach to manage Fournier’s gangrene in a patient with unknown type II diabetes: surgery, hyperbaric oxygen, and vacuum-assisted closure therapy: a case report

    Directory of Open Access Journals (Sweden)

    Pastore Antonio Luigi

    2013-01-01

    Full Text Available Abstract Introduction Fournier’s gangrene is an infectious necrotizing fasciitis of the perineum and genital regions and has a high mortality rate. It is a synergistic infection caused by a mixture of aerobic and anaerobic organisms and predisposing factors, including diabetes mellitus, alcoholism, malnutrition, and low socioeconomic status. We report a case of Fournier’s gangrene in a patient with unknown type II diabetes submitted to 24-hour catheterization 15 days before gangrene onset. Case presentation The patient, a 60-year-old Caucasian man, presented with a swollen, edematous, emphysematous scrotum with a crepitant skin and a small circle of necrosis. A lack of resistance along the dartos fascia of the scrotum and Scarpa’s lower abdominal wall fascia combined with the presence of gas and pus during the first surgical debridement also supported the diagnosis of Fournier’s gangrene. On the basis of the microbiological culture, the patient was given multiple antibiotic therapy, combined hypoglycemic treatment, hyperbaric oxygen therapy, and several surgical debridements. After five days the infection was not completely controlled and a vacuum-assisted closure device therapy was started. Conclusions This report describes the successful multistep approach of an immediate surgical debridement combined with hyperbaric oxygen and negative pressure wound therapy. The vacuum-assisted closure is a well-known method used to treat complex wounds. In this case study, vacuum-assisted closure treatment was effective and the patient did not require reconstructive surgery. Our report shows that bladder catheterization, a minimally invasive maneuver, may also cause severe infective consequences in high-risk patients, such as patients with diabetes.

  19. Hyperbaric oxygen therapy for patients with cognitive dysfunction after traumatic brain injury%高压氧治疗对脑外伤后患者认知功能障碍的影响

    Institute of Scientific and Technical Information of China (English)

    邹坤良

    2015-01-01

    目的:分析高压氧治疗对于脑外伤后患者的认知功能障碍的影响。方法:选取2011年2月至2013年1月以手术方法治疗的颅脑外伤后有认知功能障碍的患者90例,以每组45例患者随机分为观察组与对照组。在实验第7天起对于观察组患者进行高压氧治疗。结果:观察组总有效率(97.8%)高于对照组(80.0%);两组FIM评分均较治疗前有所提升。结论:对于脑外伤后患者,在常规的治疗基础上进一步辅以高压氧治疗,对于恢复患者的认知功能具有很高的临床应用价值。%ObjectiveTo analysis of hyperbaric oxygen therapy for patients with cognitive dysfunction after traumatic brain injury.Methods Selected in February 2011 to January 2011 was treated with surgical method of cognitive dysfunction after craniocerebral trauma patients 90 cases, with 45 cases in each group were randomly divided into observation group and control group. In the seventh day of hyperbaric oxygen therapy for observation group of patients. ResultsThe observation group total effective rate 97.8% higher than the control group 97.8%; Two groups of FIM score was improved the.Conclusion For patients after traumatic brain injury, the further supplemented by hyperbaric oxygen therapy on the basis of routine treatment, to restore the patient's cognitive function are of great value in clinical application.

  20. Impact of Hyperbaric Oxygenation on Blood Anticolibacillary Activity in Hepatectomy

    OpenAIRE

    Savilov, P. N.; A. Ya Turovsky; S. Ya. Dyachkova; V. N. Yakovlev

    2007-01-01

    Objective: to study the anticolibacillary activity of arterial (aorta) and venous (portal vein, hepatic veins) blood during hepatectomy and hyperbaric oxygenation (HBO).Material and methods: Experiments were conducted on 40 non-inbred female albino rats exposed to hepatic resection (15—20% of organ mass) and HBO at 3 ata for 50 min once daily within the first three days after surgery. The bactericidal action of blood serum against E.coli and the capacity of neutrophils and monocytes to absorb...

  1. Hyperbaric oxygen sensitizes anoxic Pseudomonas aeruginosa biofilm to ciprofloxacin

    DEFF Research Database (Denmark)

    Kolpen, Mette; Lerche, Christian J; Kragh, Kasper N

    2017-01-01

    fibrosis (CF) lung. Application of HBOT resulted in enhanced bactericidal activity of ciprofloxacin at clinically relevant durations and was accompanied by indications of restored aerobic respiration, involvement of endogenous lethal oxidative stress and increased bacterial growth. The findings highlight...... that oxygenation by HBOT improves the bactericidal activity of ciprofloxacin on P. aeruginosa biofilm and suggest that bacterial biofilms is sensitized to antibiotics by supplying hyperbaric O2....

  2. Osmotic phenomena in application for hyperbaric oxygen treatment.

    Science.gov (United States)

    Babchin, A; Levich, E; Melamed M D, Y; Sivashinsky, G

    2011-03-01

    Hyperbaric oxygen (HBO) treatment defines the medical procedure when the patient inhales pure oxygen at elevated pressure conditions. Many diseases and all injuries are associated with a lack of oxygen in tissues, known as hypoxia. HBO provides an effective method for fast oxygen delivery in medical practice. The exact mechanism of the oxygen transport under HBO conditions is not fully identified. The objective of this article is to extend the colloid and surface science basis for the oxygen transport in HBO conditions beyond the molecular diffusion transport mechanism. At a pressure in the hyperbaric chamber of two atmospheres, the partial pressure of oxygen in the blood plasma increases 10 times. The sharp increase of oxygen concentration in the blood plasma creates a considerable concentration gradient between the oxygen dissolved in the plasma and in the tissue. The concentration gradient of oxygen as a non-electrolyte solute causes an osmotic flow of blood plasma with dissolved oxygen. In other words, the molecular diffusion transport of oxygen is supplemented by the convective diffusion raised due to the osmotic flow, accelerating the oxygen delivery from blood to tissue. A non steady state equation for non-electrolyte osmosis is solved asymptotically. The solution clearly demonstrates two modes of osmotic flow: normal osmosis, directed from lower to higher solute concentrations, and anomalous osmosis, directed from higher to lower solute concentrations. The fast delivery of oxygen from blood to tissue is explained on the basis of the strong molecular interaction between the oxygen and the tissue, causing an influx of oxygen into the tissue by convective diffusion in the anomalous osmosis process. The transport of the second gas, nitrogen, dissolved in the blood plasma, is also taken into the consideration. As the patient does not inhale nitrogen during HBO treatment, but exhales it along with oxygen and carbon dioxide, the concentration of nitrogen in blood

  3. The Effect of Hyperbaric Oxygen on Symptoms after Mild Traumatic Brain Injury

    Science.gov (United States)

    2012-11-20

    Journal Article 3. DATES COVERED (From – To) Aug 2008 – Dec 2013 4. TITLE AND SUBTITLE The Effect of Hyperbaric Oxygen on Symptoms after Mild...absolute (ATA) hyperbaric oxygen (HBO2) on post-concussion symptoms in 50 military service members with at least one combat-related, mild traumatic brain...symptoms after mild TBI. 15. SUBJECT TERMS: hyperbaric oxygen, HBOT, HBO, HBO2, traumatic brain injury, TBI, mTBI, post-traumatic stress disorder, PTSD

  4. The effects of different hyperbaric oxygen manipulations in rats after traumatic brain injury.

    Science.gov (United States)

    Yang, Yang; Zhang, Yong-Gang; Lin, Guo-An; Xie, He-Qiu; Pan, Hai-Tao; Huang, Ben-Qing; Liu, Ji-Dong; Liu, Hui; Zhang, Nan; Li, Li; Chen, Jian-Hua

    2014-03-20

    The protective effects of hyperbaric oxygenation following traumatic brain injury have been widely investigated; however, few studies have made systematic comparisons between the different hyperbaric oxygenation manipulations and their corresponding effects. In this study, male Sprague-Dawley rats were observed at 4h, 15d and 75d after traumatic brain injury. The effects of the different hyperbaric oxygenation manipulations on the rats were compared based on morphological, molecular biological and behavioral tests. Our results showed that hyperbaric oxygenation inhibited cell apoptosis in the rat hippocampus and improved their physiological functions. The effects observed in the hyperbaric oxygen-early group were better than the hyperbaric oxygen-delayed group, and the hyperbaric oxygen-early-delayed group demonstrated the best effects among all the groups. Our results showed the hyperbaric oxygenation was recommended early and delayed post-traumatic brain injury and exposure to hyperbaric oxygenation should be prolonged. These findings provide new ideal therapeutic insight for the clinical treatment of traumatic brain injury.

  5. The effect of hyperbaric oxygen treatment on aspiration pneumonia.

    Science.gov (United States)

    Sahin, Sevtap Hekimoglu; Kanter, Mehmet; Ayvaz, Suleyman; Colak, Alkin; Aksu, Burhan; Guzel, Ahmet; Basaran, Umit Nusret; Erboga, Mustafa; Ozcan, Ali

    2011-08-01

    We have studied whether hyperbaric oxygen (HBO) prevents different pulmonary aspiration materials-induced lung injury in rats. The experiments were designed in 60 Sprague-Dawley rats, ranging in weight from 250 to 300 g, randomly allotted into one of six groups (n = 10): saline control, Biosorb Energy Plus (BIO), hydrochloric acid (HCl), saline + HBO treated, BIO + HBO treated, and HCl + HBO treated. Saline, BIO, HCl were injected into the lungs in a volume of 2 ml/kg. A total of seven HBO sessions were performed at 2,4 atm 100% oxygen for 90 min at 6-h intervals. Seven days later, rats were sacrificed, and both lungs in all groups were examined biochemically and histopathologically. Our findings show that HBO inhibits the inflammatory response reducing significantly (P fibrosis, granuloma, and necrosis formation in different pulmonary aspiration models. Pulmonar aspiration significantly increased the tissue HP content, malondialdehyde (MDA) levels and decreased (P < 0.05) the antioxidant enzyme (SOD, GSH-Px) activities. HBO treatment significantly (P < 0.05) decreased the elevated tissue HP content, and MDA levels and prevented inhibition of SOD, and GSH-Px (P < 0.05) enzymes in the tissues. Furthermore, there is a significant reduction in the activity of inducible nitric oxide synthase, TUNEL and arise in the expression of surfactant protein D in lung tissue of different pulmonary aspiration models with HBO therapy. It was concluded that HBO treatment might be beneficial in lung injury, therefore, shows potential for clinical use.

  6. Comparison of simultaneous systemic steroid and hyperbaric oxygen treatment versus only steroid in idiopathic sudden sensorineural hearing loss.

    Science.gov (United States)

    Ersoy Callioglu, Elif; Tuzuner, Arzu; Demirci, Sule; Cengiz, Ceyhun; Caylan, Refik

    2015-01-01

    A retrospective chart review to assess the effectiveness of hyperbaric oxygen treatment in sudden sensorineural hearing loss. 44 patients aged between 17-67 years diagnosed with idiopathic sensorineural hearing loss less than 30 days were admitted to our clinic Patients were treated with systemic steroid alone or systemic steroid plus hyperbaric oxygen therapy. In the comparison of two groups, there was no statistically significant difference of audiometric evaluation (P>0.0028) found in hearing improvement for each frequency on 5th day of the treatment and post treatment. Age (≤45 and >45) and initial hearing level (≤60 dB. And >60 dB.) does not seem to be an influential factor according to the results of the study (P>0.0007). The present study did not show more superior healing effect of hyperbaric oxygen therapy added to systemic steroid therapy than steroid infusion alone. The results are consistent with those of some papers. However there are also conflicting data that support significant effect of hyperbaric oxygen therapy. Routine administration of this therapy seems to be unnecessary in view of these results.

  7. Resultados iniciais da oxigenoterapia hiperbárica empacientes em lista de espera para o transplante hepático Preliminary results of hyperbaric oxygen therapy on patients on the waiting list for liver transplantation

    Directory of Open Access Journals (Sweden)

    Flávio Kreimer

    2011-03-01

    benefited with hyperbaric oxygen therapy. AIM: To evaluate clinical and laboratorial data regarding liver function in cirrhotic patients selected for liver transplantation, submitted to hyperbaric oxygen therapy. METHOD: A prospective interventional study was designed, wherein 10 patients were randomized amongst cirrhotic patients selected for liver transplantation. The ages ranged from 20 to 65 years, and all patients presented with a MELD score greater than 15. All patients were submitted to nine sessions of hyperbaric oxygen therapy, on alternated days with the duration of 60 minutes per session, with oxygen atmosphere of 100% and a 2,8 ATM pressure. Dependent parameters included were biochemical and hematologic laboratory values, evaluated before and after hyperbaric oxygen therapy sessions, besides clinical parameters, evaluated considering the Child-Turcotte-Pugh and the MELD scores. Statistical analysis was performed with SPSS (Statistcal Package for Social Sciences. RESULTS: Three patients (30% reported decrease in the number and intensity of encephalopathy. There were no cases of spontaneous bacterial peritonitis and gastrointestinal bleeding, and there were no increases on the severity of ascitis. Two patients reported improvement on pruritus, and four improvement on the general status for few weeks following hyperbaric oxygen sessions. CONCLUSION: Hyperbaric oxygen therapy may improve liver function in cirrhosis, and may help to control complications related to liver failure on the preoperative evaluation for liver transplantation.

  8. Use of Hyperbaric Oxygen in Experimental Frost-Bite

    Directory of Open Access Journals (Sweden)

    Bal Krishna

    1978-04-01

    Full Text Available Frost bite produced in rates by exposing them to -15 degree calcius and the extent of injury in the hind limbs and the tail was assessed at the end of 15 days. Hyperoxic treatment at normal atmospheric pressure and 1.5 atmosphere was given to experimental groups for 30 minutes daily for seven days in a hyperoxic chamber immediately after cold exposure. The controls were not given any treatment. Single oxygen treatment at normal atmosphere pressure was of no value, however, repeated hyperoxic treatment showed limited improvement but repeated treatment for seven days with hyperbaric oxygen at 1.5 atmosphere showed distinct recovery of frozen parts.

  9. Factors Relevant to the Prognosis of Patients with Sudden Deafness after Hyperbaric Oxygen Therapy%高压氧综合治疗突发性耳聋预后相关因素分析

    Institute of Scientific and Technical Information of China (English)

    李琴; 吴嗣洪; 唐守英; 张惠华; 曹晓燕; 葛秀英

    2014-01-01

    Objective To establish a scoring model that predicts the prognosis of patients with sudden deafness after hyperbaric oxygen therapy based on clinical data and to evaluate the efficacy of the model. Methods 188 patients with sudden deafness(221 ears)who received hyperbaric oxygen therapy were divided into two groups: 168 patients(201 ears) in training group and 20 patients(20 ears)in testing group. With a self-controlled experimental design, the training group were divided into the effective group and ineffective group. Chi-square test was applied to choose statistically significant risk factors which were used to establish a scoring model. Receiver operator characteristic (ROC) curve was then used to analyze the scoring model. Results The factors that had adverse effects on the prognosis of patients with sudden deafness after hyperbaric oxygen therapy included sudden deafness with vertigo, descending/completely deaf audiogram, prehospital delay time≥15 d, hyperbaric oxygen therapy<2 courses, beginning time of treatment≥fifteen days after onset, average hearing loss at the first visit≥60 dB HL, sudden deafness with HBP(high blood pressure)/DM(diabetes mellitus)or both. The ROC curve analysis revealed that the area under the curve (AUC) for the scoring model was 0.967, which was significantly different from the AUC(0.5) under the completely random circumstances(P<0.05). The appraisal of prospective misjudge possibility was applied to the scoring model in testing samples and the results showed the misjudgement rate was about 10%. Conclusion This scoring model based on clinical data can be used to predict the prognosis of patients with sudden deafness after hyperbaric oxygen therapy.%目的:根据临床资料建立预测高压氧(hyperbaric oxygen,HBO)综合治疗突发性耳聋(sudden deafness,SD)预后的评分模型,并评价科学性。方法连续选择188例(221耳)接受高压氧综合治疗的SD患者,随

  10. Altitude mountain sickness among tourist populations: a review and pathophysiology supporting management with hyperbaric oxygen.

    Science.gov (United States)

    Butler, Gleen J; Al-Waili, N; Passano, D V; Ramos, J; Chavarri, J; Beale, J; Allen, M W; Lee, B Y; Urteaga, G; Salom, K

    2011-01-01

    In the mountain climbing community, conventional prevention of altitude mountain sickness (AMS) relies primarily on a formal acclimatization period. AMS symptoms during mountaineering climbs are managed with medication, oxygen and minor recompression (1524-2438 m altitude) using a portable chamber, such as the Gamow Bag. This is not always an acceptable therapy alternative in a predominantly elderly tourist population. The primary problem with reduced pressure at high altitude is hypoxaemia, which causes increased sympathetic activity, induces pulmonary venous constriction, while increasing pulmonary blood flow and regional perfusion. Rapid assents to altitude contribute to an increased incidence of decompression sickness (DCS). The treatment of choice for DCS is hyperbaric oxygenation, thus, treatment of high-altitude induced hypoxaemia using hyperbaric oxygenation (HBO(2)) is logical. Life Support Technologies group and the Center for Investigation of Altitude Medicine (CIMA, in Cusco, Peru) propose a comprehensive and multidisciplinary approach to AMS management. This approach encompasses traditional and advanced medical interventions including the use of a clinical HBO(2) chamber capable of recompression to three times greater than sea level pressure (3 atmosphere absolute (ATA)). The system uses a series of AMS hyperbaric treatment profiles that LST has previously developed to the US military and NASA, and that take greater advantage of vasoconstrictive effects of oxygen under true hyperbaric conditions of 1.25 ATA. These profiles virtually eliminate AMS rebound after the initial treatment often seen in conventional AMS treatment, where the patient is either treated at altitude, or does not recompress back to sea level or greater pressure (1.25 ATA), but returns directly to the same altitude where AMS symptoms first manifested.

  11. Hyperbaric oxygen promotes malignant glioma cell growth and inhibits cell apoptosis.

    Science.gov (United States)

    Wang, Yong-Gang; Zhan, Yi-Ping; Pan, Shu-Yi; Wang, Hai-Dong; Zhang, Dun-Xiao; Gao, Kai; Qi, Xue-Ling; Yu, Chun-Jiang

    2015-07-01

    Glioblastoma multiforme (GBM) is the most frequently diagnosed intracranial malignant tumor in adults. Clinical studies have indicated that hyperbaric oxygen may improve the prognosis and reduce complications in glioma patients; however, the specific mechanism by which this occurs remains unknown. The present study investigated the direct effects of hyperbaric oxygen stimulation on glioma by constructing an intracranial transplanted glioma model in congenic C57BL/6J mice. Bioluminescent imaging (BLI) was used to assess the growth of intracranial transplanted GL261-Luc glioma cells in vivo, while flow cytometric and immunohistochemical assays were used to detect and compare the expression of the biomarkers, Ki-67, CD34 and TUNEL, reflecting the cell cycle, apoptosis and angiogenesis. BLI demonstrated that hyperbaric oxygen promoted the growth of intracranially transplanted GL261-Luc glioma cells in vivo. Flow cytometric analysis indicated that hyperbaric oxygen promoted GL261-Luc glioma cell proliferation and also prevented cell cycle arrest. In addition, hyperbaric oxygen inhibited the apoptosis of the transplanted glioma cells. Immunohistochemical analysis also indicated that hyperbaric oxygen increased positive staining for Ki-67 and CD34, while reducing staining for TUNEL (a marker of apoptosis). The microvessel density was significantly increased in the hyperbaric oxygen treatment group compared with the control group. In conclusion, hyperbaric oxygen treatment promoted the growth of transplanted malignant glioma cells in vivo and also inhibited the apoptosis of these cells.

  12. Hyperbaric oxygen therapy and mechanical resistence of the colonics anastomosis in rats with peritonitis Oxigenoterapia hiperbárica e resistência mecânica das anastomoses cólicas em ratos com peritonite

    Directory of Open Access Journals (Sweden)

    Antonio Angelo Rocha

    2010-08-01

    Full Text Available PURPOSE: To analyze the effects of hyperbaric oxygen therapy (HBO on the mechanical resistance of anastomosis performed in rats' distal colon presenting peritonitis induced by ligature and cecal punction using the Total Energy Rupture biomechanical test (ETR. METHODS: It was used 45 rats divided into three groups of 15 animals each. In Control Group (CG, it was performed anastomosis in distal colon without peritonitis. In Peritonitis Group (PG, it was performed anastomosis six hours after the induction of peritonitis by ligature and cecal punction. In Hyperbaric Chamber Group (HCG, it was performed six hours after the induction of peritonitis by ligature and cecal punction. The animals on CG and PG were kept at place air while the animals on HCG were placed on an experimental hyperbaric chamber in order to inhale oxygen at 100%, two absolute atmospheres, for 120 minutes, for four consecutive days. Euthanasia took place on the fifth day of the experiment. All the animals underwent to Total Energy Rupture Biomechanical Resistance test (ETR. Total Energy Rupture was defined as the necessary internal energy stored up to promote the colon rupture after an external traction force imposition. RESULTS: The Peritonitis Group presents smaller average ETR than Control Group. There was no statistical difference between Peritonitis Group and Hyberbaric Chamber Group. CONCLUSION: Hyperbaric oxygen therapy did not alter the mechanical resistance of anastomosis performed in distal colon of rats under the presence of peritonitis induced by ligature and cecal puncture.OBJETIVO: Analisar o efeito da oxigenoterapia hiperbárica (HBO sobre a resistência mecânica de anastomoses realizadas em cólon distal de ratos na presença de peritonite induzida por ligadura e punção cecal utilizando o teste biomecânico de Energia Total de Ruptura (ETR. MÉTODOS: Foram utilizados 45 ratos distribuídos em três grupos de 15 animais. No Grupo Controle (GC, realizou

  13. 高压氧治疗突发性聋疗效及相关因素分析%Effect of hyperbaric oxygen therapy on sudden hearing loss and its relevant factors

    Institute of Scientific and Technical Information of China (English)

    贾桂芬

    2013-01-01

    Objective To evaluate the efficacy of hyperbaric oxygen in treatment of sudden deafness and to analyze related factors of deafness,in order to provide the basis for clinical treatment.Methods 72 cases with sudden deafness were admitted.41 cases (total of 43 ears) were given conventional treatment.31 cases (total of 32 ears) were given hyperbaric oxygen plus conventional treatment.The influencing factors of deafness in 32 cases were also analyzed.Results The total effective rate of hyperbaric oxygen therapy group was 81.25%,that of the conventional drug treatment group was 65.12%,the difference was statistically significant (P < 0.05).In hyperbaric oxygen therapy group,the visiting time less than 24h,the effective rate was 100.00%,which was higher than visiting time 1 to 14 days (90.00%) and more than 15 days (37.50%) (P < 0.05).The effective rate of visiting time between 10-20 days and more than 20 days was significant different (P < 0.05).The effective rate from high to low was 15-34 years old,35-54 years old and ≥55 years old.The effective rate of 15-34 and 35-54 years old group was significantly higher than ≥55 group (P < 0.05).The effective rate of mild deafness was 100.00 %,which was significantly higher than moderate deafness 84.62% and severe hearing loss 20.00% (all P < 0.05).Conclusion The effect of hyperbaric oxygen plus drug in treatment of sudden deafness was significant.The sudden deafness shoud be treated early in clinical by hyperbaric oxygen.%目的 探讨高压氧治疗突发性聋的疗效及相关因素,为临床治疗提供依据.方法 选择突发性聋患者72例,其中常规治疗41例,左右聋总数为43耳.高压氧加常规治疗31例,左右聋总数为32耳.并对32例聋影响因素进行分析.结果 总有效率高压氧治疗组为81.25%,常规药物治疗组为65.12%,差异有统计学意义(P<0.05);高压氧治疗不同就诊时间患者疗效比较,就诊时间小于24 h者有效率为100.00

  14. Successful therapy of progressive rhino-orbital mucormycosis caused by Rhizopus arrhizus with combined and sequential antifungal therapy, surgery and hyperbaric therapy

    Directory of Open Access Journals (Sweden)

    Adrián Imbernón

    2014-10-01

    Full Text Available We present a case of rhino-orbitary mucormycosis which progressed despite liposomal amphotericin and early surgical debridement. Combined echinocandin and high dose liposomal amphotericin, repeated debridement, prolonged therapy with hyperbaric oxygen and continued therapy with posaconazole, along with strict diabetic control, allowed cure without disfigurement.

  15. Effects of hyperbaric oxygen therapy on recovery of cognitive function in stroke patients on hemodialysis%高压氧对维持性血液透析尿毒症并发脑卒中患者认知功能恢复的影响

    Institute of Scientific and Technical Information of China (English)

    常靖; 宋修芹; 邱晓军

    2012-01-01

    40例维持性血液透析尿毒症并发脑卒中患者随机分为高压氧疗组和常规治疗组,各20例.结果显示,两组治疗后与治疗前神经功能缺损评分、简易精神状态检查表(MMSE)评分、日常生活能力(ADL)评分分别比较,差异均有统计学意义(P<0.01),且高压氧疗组治疗后各评分均高于常规组治疗后评分,差异亦有统计学意义(均P<0.01).高压氧能显著改善维持性血液透析尿毒症并发脑卒中患者的认知功能.%To explore the clinical efficacies of hyperbaric oxygen therapy on the recovery of cognitive function in stroke patients on hemodialysis.Forty stroke patients on hemodialysis were assigned randomly into hyperbaric oxygen therapy (HBO) (n =20 ) and routine therapy groups (n =20).Patients of HBO group received both hyperbaric oxygen therapy and routine therapy.Nerves functions and cognitive function were observed before and after therapy to compare the clinical outcomes.Neuropsychological tests,minimental status examination (MMSE) and activities of daily living (ADL) were used for assessing cognitive function.Then the outcomes were compared with those of the control group.Nerves function and cognitive dysfunction of the treatment group had significant improvement (P < 0.01).Hyperbaric oxygen can significantly improve cognitive dysfunction in stroke patients on hemodialysis.

  16. Clinical observation and nursing of hyperbaric oxygen therapy for 42 cases with sudden nerve deafness%高压氧治疗突发神经性耳聋42例的疗效观察及护理

    Institute of Scientific and Technical Information of China (English)

    张艳

    2016-01-01

    Objective To observe the clinical application of hyperbaric oxygen therapy combined with comprehensive nursing in sudden nerve deafness. Methods Ninety patients with sudden nerve deafness were selected and divided into study group and control group according to different therapies and nursing methods. The study group adopted the hyperbaric oxygen therapy combined with comprehensive nursing ;control group adopted the conventional therapy (Dextranum ,Fufang Dansheng extract) combined with comprehensive nursing. The clinical efficacy ,compliance ,degree of deafness and curative effect of two groups was observed. Results The effective rate of study group (92.86% ) was significantly higher than that of control group (77.08% ) (P<0.05);the rate of favorable compliance and unfavorable compliance of study group was 69.05% and 7.14%while the rate of control group was 41.67% and 25.00% (P<0.05);for patients with deafness (<60 dB) ,the cure rate of study group and control group was 34.62% and 23.33% ;for patients with deafness (≥60 dB) ,the curate rate of study group and control group was 6.25% and 0 (P< 0.05). Conclusion The hyperbaric oxygen therapy combined with comprehensive nursing has a favorable effect in sudden nerve deafness. The curative effect in patients with milder deafness is better than pa-tients with severe deafness. The compliance is also improved. It is worthy of promotion.%目的:观察高压氧治疗配合综合性护理在突发神经性耳聋中的临床应用效果。方法临床纳入突发神经性耳聋患者90例,根据临床治疗及护理方案的不同分为研究组与对照组。研究组给予高压氧配合综合性护理,对照组给予常规治疗(右旋糖酐、复方丹参液等)配合常规护理。观察2组临床疗效、治疗依从性以及耳聋程度与疗效关系。结果研究组有效率92.86%,对照组为77.08%,差异有统计学意义( P<0.05);研究组治疗依从性好、差者分别占69.05

  17. Observation on Therapeutic Effect in Treatment of Hypoxemic Infantile Encephalopathy by Acupuncture plus Hyperbaric Oxygen

    Institute of Scientific and Technical Information of China (English)

    刘锦; 郭峰; 蒯乐

    2006-01-01

    目的:探讨针刺结合高压氧治疗小儿缺氧缺血性脑病(HIE)的疗效.方法:59例HIE患儿,分为治疗组(33例),对照组(26例),两组均采用纠正酸中毒,控制脑水肿及惊厥,静脉滴注脑活素或胞二磷胆碱等基础治疗,治疗组则采用针刺结合高压氧治疗,对照组则只采用高压氧治疗.结果:治疗组与对照组总有效率分别为97.0%,73.1%.经统计学处理P<0.01差异非常显著.结论:针刺加高压氧治疗HIE优于单用高压氧治疗,主要表现在能缩短疗程,提高治愈率,降低死亡率,减少后遗症的发生,HIE患儿应尽早治疗.%Objective: To investigate the therapeutic effect of acupuncture plus hyperbaric oxygen in treating hypoxemic infantile encephalopathy (HIE). Methods: Fifty-nine HIE children were divided into treatment (33 cases) and control (26 cases) groups. Both groups were treated by basic therapy of removing acidosis, controlling cerebral edema and convulsion, and intravenous drip of cerebrolysin or citicoline. The treatment group was treated by acupuncture plus hyperbaric oxygen and the control group was treated by hyperbaric oxygen only. Results: The total effective rate was 97.0% in the treatment group and 73.1% in the control group. Statistical analysis showed a highly significant difference (P<0.01). Conclusion: Acupuncture plus hyperbaric oxygen was better than simple hyperbaric oxygen in treating HIE. Its main manifestations were shortening the course of disease, increasing cure rate, decreasing death rate and reducing the occurrence of sequelae.HIE children should be treated as early as possible.

  18. 高压氧治疗对0~1级糖尿病足患者的治疗效果%Effect of Hyperbaric Oxygen Therapy on Patients with Early Diabetic Foot

    Institute of Scientific and Technical Information of China (English)

    邱惠芝

    2015-01-01

    Objective To observe the effect of hyperbaric oxygen therapy on 0-1 early diabetic foot patients. Methods A total of 60 cases of diabetic foot patients were randomly divided into the study group and the control group,30 cases in eac. The patients were unified for conventional treatment,and treatment group on the basis obtained pure oxygen inhalation in hyperbaric ox-ygen chamber. Results ①After treatment,13 cases were cured,7 cases markedly effective,9 cases effective,1 cases ineffective, the total efficiency of 95% in the study group. 11 cases were cured,9 cases markedly effective,7 cases effective,3 cases ineffec-tive,the total efficiency of 85% in The control group. The efficacy of the two groups had significant difference(P<0. 05).②After treatment,the study group on foot pain caused by time was higher than the control group,the difference was significant(P<0. 05).③After treatment, study group was lower than the control group in the foot skin temperature anomaly,the difference was significant (P<0. 05).④After treatment, comparison of peripheral nervous system diseases symptoms and signs score,the study group was lower than the control group,the difference was significant(P<0. 05). Conclusion Hyperbaric oxygen therapy has obvious cura-tive effect on early diabetic foot patients with grade 0-1.%目的 观察高压氧治疗对0~1级糖尿病足患者的治疗效果. 方法 纳入60例确诊为糖尿病足的患者,将患者随机分为研究组与对照组,每组各30例. 患者均统一实行常规治疗措施,研究组在此基础上进入高压氧舱内吸入纯氧治疗. 观察两组患者治疗效果. 结果 ①治疗后,研究组治愈13 例,显效7 例,有效9 例,无效1 例,总有效率95. 00%. 对照组临床治愈11例,显效9 例,有效7 例,无效3 例,总有效率85. 0%. 两组疗效比较差异有统计学意义(P<0. 05). ②治疗后研究组步行引起疼痛时间高于对照组,差异有统计学意义(P<0. 05). ③治疗后研究组踝

  19. Comprehensive management of Fournier's gangrene with hyperbaric oxygen therapy:A report of 14 cases%联合高压氧综合治疗 Fournier坏疽(附14例报告)

    Institute of Scientific and Technical Information of China (English)

    胡丹; 陈金波; 李超; 程序

    2015-01-01

    Objectives To investigate the etiology,diagnosis, prognosis of hyperbaric oxygen therapy t and prognosis of Fournier's gangrene(FG).Methods A retrospective study was conducted in our hospital.We ana-lyzed the clinical data of 14 Fournier's gangrene cases, and discussed our experience in diagnosis and treatment.All patients were treated with comprehensive treatment measures of early and aggressive debridement and drainage , anti-infection with adequate antibiotic and hyperbaric oxygen therapy .Penile amputation plus suprapubic cystostomy and colostomy were performed during debridement in 2 cases respectively.During the second session, scrotoplasty was performed for 4 cases, scrotal dermatoplasty for 8, urethral fistulation and scrotal dermatoplasty after penile amputa-tion for 1 case.Results Thirteen patients were recovered and discharged from hospital after our comprehensive treatment, and only one patient died for multiple organ disfunction syndrome ( MODS) induced by sepsis.Conclu-sions Early diagnosis and treatment are very essential for FG patients .Management of FG consists of early and ag-gressive debridement and drainage, administration of adequate broad -spectrum antibiotics and hyperbaric oxygen therapy.Reconstructing the skin of scrotal, perineum and penis should be proceeded after the wound without signifi-cant inflammation and fresh granulation tissue grows in the second session .%目的:探讨Fournier坏疽(Fournier's gangrene, FG)的发病因素、诊断、联合高压氧的治疗方法及预后。方法对收治的14例FG患者的临床资料进行回顾性分析,并探讨我们的诊治经验。全部患者均早期采用外科清创引流、足量抗生素抗感染、高压氧等联合治疗措施,清创同时行阴茎切除术+膀胱造瘘及肠造瘘各1例。 II期行阴囊缝合成型术4例,阴囊植皮术8例,阴茎切除术后行尿道外口成型+阴囊植皮1例。结果痊愈出院13例,仅1例患者因脓毒败

  20. Hyperbaric oxygen treatment promotes neural stem cell proliferation in the subventricular zone of neonatal rats with hypoxic-ischemic brain damage.

    Science.gov (United States)

    Feng, Zhichun; Liu, Jing; Ju, Rong

    2013-05-05

    Hyperbaric oxygen therapy for the treatment of neonatal hypoxic-ischemic brain damage has been used clinically for many years, but its effectiveness remains controversial. In addition, the mechanism of this potential neuroprotective effect remains unclear. This study aimed to investigate the influence of hyperbaric oxygen on the proliferation of neural stem cells in the subventricular zone of neonatal Sprague-Dawley rats (7 days old) subjected to hypoxic-ischemic brain damage. Six hours after modeling, rats were treated with hyperbaric oxygen once daily for 7 days. Immunohistochemistry revealed that the number of 5-bromo-2'-deoxyuridine positive and nestin positive cells in the subventricular zone of neonatal rats increased at day 3 after hypoxic-ischemic brain damage and peaked at day 5. After hyperbaric oxygen treatment, the number of 5-bromo-2'-deoxyuridine positive and nestin positive cells began to increase at day 1, and was significantly higher than that in normal rats and model rats until day 21. Hematoxylin-eosin staining showed that hyperbaric oxygen treatment could attenuate pathological changes to brain tissue in neonatal rats, and reduce the number of degenerating and necrotic nerve cells. Our experimental findings indicate that hyperbaric oxygen treatment enhances the proliferation of neural stem cells in the subventricular zone of neonatal rats with hypoxic-ischemic brain damage, and has therapeutic potential for promoting neurological recovery following brain injury.

  1. Hyperbaric oxygen treatment promotes neural stem cell proliferation in the subventricular zone of neonatal rats with hypoxic-ischemic brain damage

    Institute of Scientific and Technical Information of China (English)

    Zhichun Feng; Jing Liu; Rong Ju

    2013-01-01

    Hyperbaric oxygen therapy for the treatment of neonatal hypoxic-ischemic brain damage has been used clinically for many years, but its effectiveness remains controversial. In addition, the mechanism of this potential neuroprotective effect remains unclear. This study aimed to investigate the influence of hyperbaric oxygen on the proliferation of neural stem cells in the subventricular zone of neonatal Sprague-Dawley rats (7 days old) subjected to hypoxic-ischemic brain damage. Six hours after modeling, rats were treated with hyperbaric oxygen once daily for 7 days. Immunohistochemistry revealed that the number of 5-bromo-2′-deoxyuridine positive and nestin positive cells in the subventricular zone of neonatal rats increased at day 3 after hypoxic-ischemic brain damage and peaked at day 5. After hyperbaric oxygen treatment, the number of 5-bromo-2′- deoxyuridine positive and nestin positive cells began to increase at day 1, and was significantly higher than that in normal rats and model rats until day 21. Hematoxylin-eosin staining showed that hyperbaric oxygen treatment could attenuate pathological changes to brain tissue in neonatal rats, and reduce the number of degenerating and necrotic nerve cells. Our experimental findings indicate that hyperbaric oxygen treatment enhances the proliferation of neural stem cells in the subventricular zone of neonatal rats with hypoxic-ischemic brain damage, and has therapeutic potential for promoting neurological recovery following brain injury.

  2. Oxygen Therapy

    OpenAIRE

    2000-01-01

    LTOT is prescribed for people with chronic lung disease in whom there is a decrease in the ability of the lungs to supply enough oxygen to the body. The heart is obliged to pump faster to meet the body's oxygen requirements. This may place undue stress on the heart, resulting in palpitations, dizziness and fatigue. A low oxygen level in arterial blood is also harmful to the heart, the brain and the pulmonary blood vessels. Oxygen therapy is used to break this cycle. A person with low blood ox...

  3. The effects of hyperbaric air and hyperbaric oxygen on blood-brain barrier integrity in rats.

    Science.gov (United States)

    Cevik, Nihal Gunes; Orhan, Nurcan; Yilmaz, Canan Ugur; Arican, Nadir; Ahishali, Bulent; Kucuk, Mutlu; Kaya, Mehmet; Toklu, Akin Savas

    2013-09-19

    Hyperbaric oxygen (HBO) treatment yields conflicting results on blood-brain barrier (BBB) integrity under various pathological conditions and the effects of HBO on healthy brain is poorly understood. In this experimental study, the effects of HBO on BBB integrity were investigated in comparison with hyperbaric air (HBA) in intact rats. Four sessions of HBA or HBO were applied to intact rats in 24h. BBB integrity was functionally and structurally evaluated by determining extravasation of Evans blue (EB) dye and horseradish peroxidase (HRP) tracers. In immunohistochemical evaluation, relative staining intensity for occludin, a tight junction (TJ) protein, and aquaporin 4 (AQP4), a water-channel protein, was detected in the barrier type of microvessels of brain by image analysis. BBB permeability to EB dye significantly increased in animals in HBO treatment group compared to those in HBA and control groups (p<0.05). The immunoreactivity of occludin, a tight junction protein, remained essentially unaltered in capillaries of hippocampus in all groups. In animals exposed to HBO, AQP4 immunoreactivity significantly increased in parietal cortex compared to those in HBA and control groups (p<0.01). Ultrastructurally, frequent vesicles containing HRP reaction products were observed in capillary endothelial cells in cerebral cortex and hippocampus of rats subjected to both HBA and HBO. Our results indicate that the HBO administration to intact rats increased BBB permeability to both EB and HRP while HBA increased only HRP extravasation in these animals. The results of this study suggest that HBA also impairs the BBB integrity in intact rats as well as HBO.

  4. Uso da oxigenoterapia hiperbárica em pacientes de um serviço de reumatologia pediátrica Hyperbaric oxygen therapy in patients of a pediatric rheumatology service

    Directory of Open Access Journals (Sweden)

    Juliana Figueira M. R. Rossi

    2005-04-01

    Full Text Available A oxigenoterapia hiperbárica consiste na respiração de oxigênio puro sob pressão maior que uma atmosfera e vem sendo empregada no tratamento adjuvante de lesões ulceradas de várias etiologias. Foram analisados retrospectivamente os prontuários de seis pacientes atendidos no Ambulatório de Reumatologia Pediátrica do Instituto da Criança do Hospital das Clínicas da FMUSP entre 1996 e 2002, submetidos à oxigenoterapia hiperbárica. Esse procedimento foi indicado pela presença de osteomielite crônica e lesões ulceradas (por vasculite ou infecção que não responderam ao tratamento habitual. Dois pacientes apresentaram poliarterite nodosa cutânea, dois osteomielite crônica multifocal recorrente, um esclerodermia cutânea difusa e um pioderma gangrenoso. Cinco pacientes eram do sexo feminino (idade variou de 6 a 13,2 anos. As sessões de oxigenoterapia hiperbárica foram realizadas sob pressões que variaram de 2,4 a 2,8 atmosferas absolutas, com duração de duas horas. O número mínimo de sessões foi 18 e o máximo 80. Em cinco pacientes houve completa cicatrização das lesões. A paciente com esclerodermia cutânea abandonou o tratamento após a décima oitava sessão, pois retornou a sua cidade natal, com melhora parcial das lesões cutâneas. O principal evento adverso durante as sessões foi otalgia, após as primeiras sessões, que desapareceu com diminuição da pressão dentro da câmara e da duração da sessão. Não foram observados perfuração timpânica ou outros eventos adversos. A oxigenoterapia hiperbárica foi eficaz e bem tolerada nos pacientes com doenças reumatológicas e lesões vasculíticas ulceradas ou infectadas e osteomielite crônica.The hyperbaric oxygen therapy consists in the breathing of pure oxygen under pressures higher than one atmosphere and has been used in the treatment of ulcerated lesions of various etiologies. Six patients followed at the Rheumathology Unit, Instituto da Crian

  5. Nitrogen Metabolism During Hepatectomy and Hyperbaric Oxygenation: Experimental Study

    Directory of Open Access Journals (Sweden)

    P. N. Savilov

    2007-01-01

    Full Text Available Objective: to examine nitrogen metabolism in the organs of the portal system during liver resection (LR and hyperbaric oxygenation (HBO.Material and methods: Experiments were conducted on 65 female albino rats. LR was made under ether anesthesia, by removing a portion of the left hepatic lobe with an electric knife, which amounted to 15—20% of the organ’s mass. HBO was performed using medical oxygen at 3 ata for 50 min once daily within the first three days after LR. Lung tissue, gastrointestinal tract (GIT, spleen, and choledochal bile were the subject of the study. The tissue and blood levels of ammonia, glutamine, and urea were measured.Results: LR leads to pathological ammonia accumulation and decreases arterial glutamine consumption in GIT organs. Concurrently, the urea contained in the organs begins to come into portal blood flow, splenic glutamine deficiency develops, and hepatic ammonia-absorptive, glutamine- and urea-excretory functions diminish. Post-LR HBO prevents the accumulation of ammonia in the liver and GIT, restores the ammonia-absorptive, glutamine- and urea-excretory functions of the liver, and stimulates its glutamine and urea accumulation. Concomitantly, under HBO, there is an increase in glutamine entrance from the GIT into blood flow, but there is a decrease in GIT urea excretion and portal venous blood ammonia levels. HBO eliminates arterial hyperammonemia after LR and splenic glutamine deficiency.Conclusion: Hyperbaric oxygen eliminates nitrogen metabolic disturbances in the portal system, regulates compensatory-adaptive ammonia metabolic reactions triggered in the GIT and spleen during LR. 

  6. Effect of hyperbaric oxygen on cyclosporine-induced nephrotoxicity and oxidative stress in rats.

    Science.gov (United States)

    Ay, Hakan; Uzun, Gunalp; Onem, Yalcin; Aydinoz, Secil; Yildiz, Senol; Bilgi, Oguz; Topal, Turgut; Atasoyu, Enes Murat

    2007-01-01

    Reactive oxygen species have been suggested to be involved in cyclosporine nephrotoxicity. Hyperbaric oxygen is known to induce the generation of reactive oxygen species in tissues. The aim of this study was to investigate whether the use of hyperbaric oxygen concurrently with cyclosporine potentiates cyclosporine nephrotoxicity by inducing oxidative stress in kidneys. The study consisted of four groups of rats: a control group, a cyclosporine group (15 mg/kg/day intraperitoneally for 14 days), a hyperbaric oxygen group (60 min. every day for five days at 2.5 atmosphere absolute), and a cyclosporine + hyperbaric oxygen group (cyclosporine 15 mg/kg/day intraperitoneally for 14 days + hyperbaric oxygen for 60 min at 2.5 atmosphere absolute every day for five days on the last five days of cyclosporine treatment). Oxidative stress was determined by measuring renal thiobarbituric acid-reactive substances content, renal superoxide dismutase, and glutathione peroxidase activities. Cyclosporine increased serum urea and creatinine levels, indicating the development of nephrotoxicity, and induced significant oxidative stress in rat kidneys. Hyperbaric oxygen alone did not alter any of the biochemical and oxidative stress parameters compared to the control group. When used concurrently with cyclosporine, hyperbaric oxygen significantly reduced cyclosporine-induced oxidative stress, but it neither attenuated nor aggravated cyclosporine-induced nephrotoxicity. These results suggest that reactive oxygen species are involved in cyclosporine nephrotoxicity, but are not the direct cause of the toxicity. Although concurrent use of cyclosporine and hyperbaric oxygen did not exacerbate cyclosporine nephrotoxicity in this model, we recommend that the renal functions of patients be monitored periodically when these treatments are used concurrently.

  7. Hyperbaric Oxygen Promotes Proximal Bone Regeneration and Organized Collagen Composition during Digit Regeneration.

    Directory of Open Access Journals (Sweden)

    Mimi C Sammarco

    Full Text Available Oxygen is critical for optimal bone regeneration. While axolotls and salamanders have retained the ability to regenerate whole limbs, mammalian regeneration is restricted to the distal tip of the digit (P3 in mice, primates, and humans. Our previous study revealed the oxygen microenvironment during regeneration is dynamic and temporally influential in building and degrading bone. Given that regeneration is dependent on a dynamic and changing oxygen environment, a better understanding of the effects of oxygen during wounding, scarring, and regeneration, and better ways to artificially generate both hypoxic and oxygen replete microenvironments are essential to promote regeneration beyond wounding or scarring. To explore the influence of increased oxygen on digit regeneration in vivo daily treatments of hyperbaric oxygen were administered to mice during all phases of the entire regenerative process. Micro-Computed Tomography (μCT and histological analysis showed that the daily application of hyperbaric oxygen elicited the same enhanced bone degradation response as two individual pulses of oxygen applied during the blastema phase. We expand past these findings to show histologically that the continuous application of hyperbaric oxygen during digit regeneration results in delayed blastema formation at a much more proximal location after amputation, and the deposition of better organized collagen fibers during bone formation. The application of sustained hyperbaric oxygen also delays wound closure and enhances bone degradation after digit amputation. Thus, hyperbaric oxygen shows the potential for positive influential control on the various phases of an epimorphic regenerative response.

  8. Hyperbaric Oxygen Promotes Proximal Bone Regeneration and Organized Collagen Composition during Digit Regeneration.

    Science.gov (United States)

    Sammarco, Mimi C; Simkin, Jennifer; Cammack, Alexander J; Fassler, Danielle; Gossmann, Alexej; Marrero, Luis; Lacey, Michelle; Van Meter, Keith; Muneoka, Ken

    2015-01-01

    Oxygen is critical for optimal bone regeneration. While axolotls and salamanders have retained the ability to regenerate whole limbs, mammalian regeneration is restricted to the distal tip of the digit (P3) in mice, primates, and humans. Our previous study revealed the oxygen microenvironment during regeneration is dynamic and temporally influential in building and degrading bone. Given that regeneration is dependent on a dynamic and changing oxygen environment, a better understanding of the effects of oxygen during wounding, scarring, and regeneration, and better ways to artificially generate both hypoxic and oxygen replete microenvironments are essential to promote regeneration beyond wounding or scarring. To explore the influence of increased oxygen on digit regeneration in vivo daily treatments of hyperbaric oxygen were administered to mice during all phases of the entire regenerative process. Micro-Computed Tomography (μCT) and histological analysis showed that the daily application of hyperbaric oxygen elicited the same enhanced bone degradation response as two individual pulses of oxygen applied during the blastema phase. We expand past these findings to show histologically that the continuous application of hyperbaric oxygen during digit regeneration results in delayed blastema formation at a much more proximal location after amputation, and the deposition of better organized collagen fibers during bone formation. The application of sustained hyperbaric oxygen also delays wound closure and enhances bone degradation after digit amputation. Thus, hyperbaric oxygen shows the potential for positive influential control on the various phases of an epimorphic regenerative response.

  9. Monitoring cardiac output during hyperbaric oxygen treatment of haemodynamically unstable patients

    DEFF Research Database (Denmark)

    Hansen, Marco Bo; Treschow, Frederik; Skielboe, Martin

    2013-01-01

    Patients suffering from necrotizing fasciitis (NF) are often haemodynamically unstable and require extended monitoring of cardiovascular parameters; yet this is limited during hyperbaric oxygen treatment (HBOT). We aimed to evaluate the use and safety of transoesophageal Doppler (TED) monitoring...

  10. Hyperbaric oxygen preconditioning improves postoperative cognitive dysfunction by reducing oxidant stress and inflammation.

    Science.gov (United States)

    Gao, Zhi-Xin; Rao, Jin; Li, Yuan-Hai

    2017-02-01

    Postoperative cognitive dysfunction is a crucial public health issue that has been increasingly studied in efforts to reduce symptoms or prevent its occurrence. However, effective advances remain lacking. Hyperbaric oxygen preconditioning has proved to protect vital organs, such as the heart, liver, and brain. Recently, it has been introduced and widely studied in the prevention of postoperative cognitive dysfunction, with promising results. However, the neuroprotective mechanisms underlying this phenomenon remain controversial. This review summarizes and highlights the definition and application of hyperbaric oxygen preconditioning, the perniciousness and pathogenetic mechanism underlying postoperative cognitive dysfunction, and the effects that hyperbaric oxygen preconditioning has on postoperative cognitive dysfunction. Finally, we conclude that hyperbaric oxygen preconditioning is an effective and feasible method to prevent, alleviate, and improve postoperative cognitive dysfunction, and that its mechanism of action is very complex, involving the stimulation of endogenous antioxidant and anti-inflammation defense systems.

  11. Evaluation of hyperbaric oxygen treatment of neuropsychiatric disorders following traumatic brain injury

    Institute of Scientific and Technical Information of China (English)

    SHI Xiao-yan; TANG Zhong-quan; SUN Da; HE Xiao-jun

    2006-01-01

    Background Improvement of clinical symptoms following hyperbaric oxygen (HBO) treatment of neuropsychiatric disorders arising from traumatic brain injury was proved by our previous study. This study was aim to obtain the evidence of other changes.Methods Three hundred and ten patients with neuropsychiatric disorders arising from traumatic brain injury were treated twice with hyperbaric oxygen. Cerebral single photon emissions computed tomography (SPECT)images and computed tomography scans (CT) before and after hyperbaric oxygen treatment, were compared.Results Before treatment, the proportion of abnormal cerebral changes detected by SPECT was 81.3% but only 15.2% by CT. After HBO treatment, 70.3% of SPECT scans showed no abnormalities and these patients were clinically improved. Treatment improved regional cerebral blood flow.Conclusion SPECT was much more sensitive than CT in the diagnosis of neuropsychiatric disorders following hyperbaric oxygen treatment of neuropsychiatric disorders arising from traumatic brain injury.

  12. P38 activation is more important than ERK activation in lung injury induced by prolonged hyperbaric oxygen.

    Science.gov (United States)

    Ma, Jun; Fang, Yi-Qun; Gu, Ai-Mei; Wang, Fang-Fang; Zhang, Shi; Li, Kai-Cheng

    2013-01-01

    Prolonged exposure to hyperbaric oxygen can cause pulmonary and nerve system toxicity. Although hyperbaric oxygen treatment has been used for a broad spectrum of ailments, the mechanisms of prolonged hyperbaric oxygen-induced lung injury are not fully understood. The purpose of the present work was to investigate the roles of ERK, p38, and caspase-3 in rat lung tissue exposed to hyperbaric oxygen at 2.3 atmospheres absolute (atm abs) for two, six and 10 hours. The results showed that the ERK and p38 were phosphorylated at two hours and reached a peak at six hours into exposure to hyperbaric oxygen. While the phosphorylation level of ERK decreased, p38 remained at a high level of activation at 10 hours. The activation of ERK and p38 was down-regulated when rats were exposed to normoxic hyperbaric nitrogen for 10 hours. However, caspase-3 was activated at six hours and 10 hours into exposure to hyperbaric oxygen. These results demonstrated different changes of activation of ERK and p38 during lung injury induced by prolonged exposure to hyperbaric oxygen. The time course changes of activated caspase-3 were similar to the process of p38 activation upon exposure to hyperbaric oxygen. In this way, activation of p38, not ERK, seems to be a mechanism associated with prolonged hyperbaric oxygen-induced lung injury.

  13. Effect of hyperbaric oxygenation on carbohydrate metabolism protein synthesis in the myocardium during sustained hypodynamia

    Science.gov (United States)

    Makarov, G. A.

    1980-01-01

    Glycolysis and the intensity of protein synthesis were studied in 140 white male rats in subcellular fractions of the myocardium during 45 day hypodynamia and hyperbaric oxygenation. Hypodynamia increased: (1) the amount of lactic acids; (2) the amount of pyruvic acid; (3) the lactate/pyruvate coefficient; and (4) the activities of aldolase and lactate dehydrogenase. Hyperbaric oxygenation was found to have a favorable metabolic effect on the animals with hypodynamia.

  14. Can hyperbaric oxygen be used to prevent deep infections in neuro-muscular scoliosis surgery?

    OpenAIRE

    Inanmaz, Mustafa Erkan; Kose, Kamil Cagri; Isik, Cengiz; Atmaca, Halil; Basar, Hakan

    2014-01-01

    Background The prevalence of postoperative wound infection in patients with neuromuscular scoliosis surgery is significantly higher than that in patients with other spinal surgery. Hyperbaric oxygen has been used as a supplement to treat postsurgical infections. Our aim was to determine beneficiary effects of hyperbaric oxygen treatment in terms of prevention of postoperative deep infection in this specific group of patients in a retrospective study. Methods Forty two neuromuscular scoliosis ...

  15. Oxybiotest project: microorganisms under pressure. Hyperbaric oxygen (HBO and simple pressure interaction on selected bacteria

    Directory of Open Access Journals (Sweden)

    Zanon Vincenzo

    2012-09-01

    Full Text Available Abstract Background HyperBaric Oxygen (HBO therapy involves exposure to pure oxygen in a pressurized room, and it is an already well-established treatment for various conditions, including those originated by serious infections. Starting from the observation of an increased number of patients who were accessing our HBO units for diseases supported from concomitant multidrug-resistant microorganisms, as well as considering the evident clinical benefit and laboratory final outcome of those patients at the end of the treatment, aim of our study was to measure, or better define at least, if there was any interaction between a hyperbaric environment and some selected microorganisms and if those positive results were due to the increased oxygen partial pressure (pO2 value or just to the increased pressure, regardless of the fraction of inspired oxygen (FiO2 applied (21÷100%. Design and methods We applied various increased pO2 values in a hyperbaric environment. Our study design was tailored in four steps to answer four specific questions, ordered in a progressive process: OxyBioTest (OBT-1,2,3, and 4. Specifically, we chose to investigate possible changes in the Minimum Inhibitory Concentration (MIC and in the Minimum Bactericidal Concentration (MBC of multi-resistant microorganisms after a single session of hyperbaric therapy. Results OBT-1 and OBT-2 provide a semi-quantitative confirmation of the bacterio-cidal and cytostatic effects of HBO. HBO is cidal only if the total exposure pressure is elevated, and cidal or cytostatic effect are not always dependent on the pO2 applied. OBT-4 has shown the adjuvant effect of HBO and antimicrobial drug against some selected bacteria. Discussion We seem allowed to hypothesize that only in case of a good approach to a lesion, permitting smaller bacterial loads thanks to surgical debridement and/or eventual antibiotic therapy for example, You can observe the clear effectiveness of the HyperBaric Oxygen (HBO

  16. Hyperbaric oxygen suppresses hypoxic-ischemic brain damage in newborn rats.

    Science.gov (United States)

    Zhu, Min; Lu, Mengru; Li, Qing-Jie; Zhang, Zhuo; Wu, Zheng-Zheng; Li, Jie; Qian, Lai; Xu, Yun; Wang, Zhong-Yuan

    2015-01-01

    The optimal therapeutic time-window and protective mechanism of hyperbaric oxygen in hypoxic-ischemic brain damage remain unclear. This study aimed to determine the neuroprotective effects of hyperbaric oxygen. Following hypoxic-ischemic brain damage modeling in neonatal rats, hyperbaric oxygen was administered at 6, 24, 48, and 72 hours and 1 week after hypoxia, respectively, once daily for 1 week. Fourteen days after hypoxic-ischemic brain damage, cell density and apoptosis rate, number of Fas-L+, caspase-8+, and caspase-3+ neuronal cells, levels of nitric oxide, malondialdehyde, and superoxide dismutase in hippocampus were examined. Morris water maze test was conducted 28 days after insult. Significant improvements were found in cell density, rate of apoptosis, oxidative stress markers, FasL, and caspases in rats treated with hyperbaric oxygen within 72 hours compared to hypoxic-ischemic injury. Similarly, time-dependent behavioral amelioration was observed in pups treated with hyperbaric oxygen. Our findings suggest that hyperbaric oxygen protects against hypoxic-ischemic brain damage by inhibiting oxidative stress and FasL-induced apoptosis, and optimal therapeutic time window is within 72 hours after hypoxic-ischemic brain damage.

  17. Infection Agents Detected with Wound Culture in Patients with Diabetic Foot who will Undergo Hyperbaric Oxygen Treatment

    OpenAIRE

    Gurkan Mert; Suleyman Metin; Senol Yildiz; Engin Karakuzu; Tolga Cakmak

    2012-01-01

    AIM: We aimed to obtain the knowledge of appropriate antibiotic therapy and to make a contribution to improving treatment efficacy by conducting a microbiological study of diabetic foot ulcers. METHOD: 30 patients (18 male and 12 female) with diabetic foot ulcer applying to our center for hyperbaric oxygen (HBO) treatment in 2010 were enrolled in this study. The wounds were graded according to Meggitt-Wagner classification system. Wound cultures were obtained before starting antibiotic therap...

  18. Effects of Hyperbaric Oxygen on Metabolic Capacity of the Skeletal Muscle in Type 2 Diabetic Rats with Obesity

    Directory of Open Access Journals (Sweden)

    Naoto Fujita

    2012-01-01

    Full Text Available We investigated whether hyperbaric oxygen enhances the oxidative metabolic capacity of the skeletal muscle and attenuates adipocyte hypertrophy in type 2 diabetic rats with obesity. Five-week-old male Otsuka Long-Evans Tokushima fatty (OLETF and Long-Evans Tokushima Otsuka (LETO rats were used as diabetic animals and nondiabetic controls, respectively, and assigned to control and hyperbaric oxygen groups. Animals in the hyperbaric oxygen group were exposed to an atmospheric pressure of 1.25 with an oxygen concentration of 36% for 3 h daily. The glucose level at 27 weeks of age was significantly higher in OLETF rats than in LETO rats, but the elevation was inhibited in OLETF rats exposed to hyperbaric oxygen. The slow-to-fast fiber transition in the skeletal muscle was observed in OLETF rats, but the shift was inhibited in OLETF rats exposed to hyperbaric oxygen. Additionally, the oxidative enzyme activity of muscle fibers was increased by hyperbaric oxygen. The adipocyte size was larger in OLETF rats than in LETO rats, but hypertrophied adipocytes were not observed in OLETF rats exposed to hyperbaric oxygen. Hyperbaric oxygen enhances glucose and lipid metabolism in the skeletal muscle, indicating that hyperbaric oxygen can prevent elevation of glucose and adipocyte hypertrophy in diabetic rats with obesity.

  19. Chamber personnel's use of Nitrox 50 during hyperbaric oxygen treatment

    DEFF Research Database (Denmark)

    Hansen, Marco Bo; Jansen, Tejs; Sifakis, Michael B.

    2013-01-01

    We aimed to evaluate the feasibility and safety of using Nitrox 50 as breathing gas during attendance in a multiplace hyperbaric chamber.......We aimed to evaluate the feasibility and safety of using Nitrox 50 as breathing gas during attendance in a multiplace hyperbaric chamber....

  20. [Effect of hyperbaric oxygenation on local tissue blood flow to a small intestine transplant intended for esophagoplasty].

    Science.gov (United States)

    Vinnitskiĭ, L I; Piuskiulian, L I; Zhidkov, I L; Demurov, E A

    1981-04-01

    The time course of the local tissue blood flow in the small intestinal graft used for esophagoplasty was studied in 54 acute experiments on rabbits exposed to hyperbaric oxygenation (1 hour, 2 ata). It has been shown that hyperbaric oxygenation prevents alterations in the local tissue blood flow in the small intestine. This fact provides evidence in favour of hyperbaric oxygenation application under clinical conditions.

  1. Effect of hyperbaric oxygen therapy on the intestinal ischemia reperfusion injury Efeito da oxigenoterapia hiperbárica na lesão por isquemia reperfusão intestinal

    Directory of Open Access Journals (Sweden)

    Rosemary Aparecida Furlan Daniel

    2011-12-01

    Full Text Available PURPOSE: Adequate tissue oxygenation is essential for healing. Hyperbaric oxygen therapy (HBOT has potential clinical applications to treat ischemic pathologies, however the exact nature of any protective effects are unclear at present. We therefore investigated the potential role of HBOT in modulating the ischemia/reperfusion (I/R injury response in intestinal model of I/R injury. METHODS: Male Wistar rats were subjected to surgery for the induction of intestinal ischemia followed by reperfusion. HBOT was provided before and/or after intestinal ischemia. Cell viability in the intestinal tissue was assessed using the MTT assay and by measuring serum malondealdehyde (MDA. Microvascular density and apoptosis were evaluated by immunohistochemistry. RESULTS: The results indicate that HBOT treatment pre- and post-ischemia reduces lesion size to the intestinal tissue. This treatment increases cell viability and reduces the activation of caspase-3, which is associated with increased number of tissue CD34 cells and enhanced VEGF expression. CONCLUSION: The hyperbaric oxygen therapy can limit tissue damage due to ischemia/reperfusion injury, by inducing reparative signaling pathways.OBJETIVO: Oxigenação tissular adequada é essencial para cicatrização. Oxigenoterapia hiperbárica (HBOT tem aplicação clínica para tratar lesões isquêmicas, entretanto a natureza exata dos mecanismos envolvidos permanece incerta. Procuramos investigar o papel potencial da HBOT na modulação da resposta a uma lesão por isquemia reperfusão (I/R intestinal em modelo de lesão de I/R. MÉTODOS: Ratos machos Wistar foram submetidos à cirurgia para a indução da isquemia intestinal seguida de reperfusão. HBOT foi fornecido antes e / ou após a isquemia intestinal. A viabilidade das células no tecido intestinal foi avaliada através do ensaio de MTT e pela medição malondealdeido (MDA no plasma. Densidade microvascular e apoptose foram avaliados por imuno

  2. 早期高压氧治疗对急性颅脑外伤患者失语症的疗效观察%Effects of early hyperbaric oxygen therapy on alogia in acute cerebral injury

    Institute of Scientific and Technical Information of China (English)

    林瑛; 李泉清; 刘代娣; 杨静; 张其清

    2009-01-01

    目的 研究早期高压氧(HBO)治疗对急性颅脑外伤患者失语症的疗效.方法 将2004年1月至2007年8月在我院住院的62例急性颅脑外伤患者分为HBO治疔组和常规治疗组,常规治疗组采用临床常规治疗,HBO治疗组在常规治疗的基础上,实施24~48次HBO治疗,并且在治疗结束后1年内每3个月进行1次随访.在治疗前、后分别采用西方失语成套测试法(western aphasia,WAB)检测并进行CT检查,对他们的语言功能和恢复情况进行评价和比较.结果 HBO治疗组显效率(83.8%)显著高于常规治疗组(54.8%),经x2检验P<0.05;CT检查证实患者病变部位阻塞的血管已经恢复冉通或已获得重建.结论 早期HBO治疗有利于促进或恢复患者的语言功能.%Objective To investigate the effects of early hyperbaric oxygen therapy on aphasia in acute cerebral injury. Methods Sixty-two patients with acute cerebral injury were admitted into the hospital from January 2004 to August 2007. They were randomly divided into the hyperbaric oxygen (HBO) group and the control group. The control group was administered with routine treatment other than HBO, while the HBO group was given 24-48 sessions of HBO treatment in addition to routine treatment. To know how they recovered, clinical follow-ups were made every 3 months, one year after the patients terminated treatment. The linguistic function of the patients was evaluated and compared by using Western Aphasia Battery (WAB) and CT before and after HBO therapy. Results Results showed that the HBO exposure group had obviously better results when it was compared with the control group ( 83. 8% : 54. 8% ). And test showed that P < 0, 05. CT examination demonstrated that the blocked vessels in the affected area were either recovered or repaired. Conclusions Early HBO therapy will help to improve or recover the linguistic function of patients with acute cerebral injury.

  3. Empleo de la oxigenoterapia mediante cámara hiperbárica en cirugía oral y maxilofacial The use of oxygen therapy by means of the hyperbaric chamber in oral and maxillofacial surgery

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    J.I. Iriarte Ortabe

    2006-02-01

    Full Text Available La oxigenoterapia hiperbárica (OHB es una modalidad de terapéutica física que se fundamenta en la obtención de presiones parciales de oxígeno elevadas, al respirar oxígeno puro en el interior de una cámara a una presión superior a la atmosférica. El objetivo de esta revisión es clarificar los mecanismos de acción y los efectos de esta terapéutica física, los problemas que puede plantear y sobre todo las indicaciones actuales. En cirugía oral y maxilofacial, la OHB se utiliza como tratamiento complementario en procesos de osteítis y osteomielitis maxilo-mandibular, en infecciones necrotizantes de partes blandas (a nivel cervical, periodontal, gingival,…, en la prevención (muy importante y el tratamiento de la osteradionecrosis, en los retrasos de cicatrización (de fracturas, de implantes dentales, de injertos/colgajos de difícil viabilidad, en la rehabilitación implantológica de pacientes oncológicos irradiados. Es preciso utilizar los protocolos establecidos y generar estudios que sostengan científicamente su utilización; de este modo se podría paliar la poca consistencia de los estudios publicados que hemos encontrado.Hyperbaric oxygen therapy (HBO is a physical therapeutic modality based on obtaining high partial pressures of oxygen, on breathing pure oxygen inside a chamber at a pressure that is greater than that of the atmosphere. The object of this revision is to clarify the action mechanisms and the effects of the physical therapy, the problems that may arise and more especially the current indications for its use. In oral and maxillofacial surgery, HBO is used as complementary treatment for maxillo-mandibular osteitis and osteomyelitis, for necrotizing infections of soft tissue (on a cervical, periodontal, gingival... level, for the prevention (very important and treatment of osteoradionecrosis, for healing delays (fractures, dental implants, grafts/flaps with difficult viability, for implantological

  4. Glasgow Coma Scale, brain electric activity mapping and Glasgow Outcome Scale after hyperbaric oxygen treatment of severe brain injury

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Objective: To study the effect of hyperbaric oxygen (HBO) treatment of severe brain injury.Methods: Fifty-five patients were divided into a treatment group (n = 35 receiving HBO therapy ) and a control group (n = 20 receiving dehydrating, cortical steroid and antibiotic therapy) to observe the alteration of clinic GCS (Glasgow Coma Scale), brain electric activity mapping (BEAM), prognosis and GOS (Glasgow Outcome Scale) before and after hyperbaric oxygen treatment.Results: In the treatment group GCS, BEAM and GOS were improved obviously after 3 courses of treatment,GCS increased from 5.1 to 14.6 ( P < 0.01-0.001 ), the BEAM abnormal rate reduced from 94.3% to 38% (P <0.01-0.001 ), the GOS good-mild disability rate was 83.7%, and the middle-severe disability rate was 26.3%compared with the control group. There was a statistic significant difference between the two groups (P < 0.01-0.001).Conclusions: Hyperbaric oxygen treatment could improve obviously GCS, BEAM and GOS of severe brain injury patients, and effectively reduce the mortality and morbidity. It is an effective method to treat severe brain injury. two g

  5. Hyperbaric oxygen therapy aggravates liver reperfusion injury in rats Oxigenoterapia hiperbárica agrava lesão de reperfusão hepática em ratos

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    Cristiano Xavier Lima

    2008-08-01

    Full Text Available PURPOSE: To evaluate the effects of hyperbaric oxygen (HO therapy in the protection against liver ischemia/reperfusion injury. METHODS: Thirty-two male Wistar rats were divided into four groups of eight animals each: group A - laparotomy and liver manipulation, group B - liver ischemia and reperfusion, group C - HO pretreatment for 60 min followed by liver ischemia and reperfusion, and group D - pretreatment with ambient air at 2.5 absolute atmospheres for 60 min followed by liver ischemia and reperfusion. Plasma was assayed for aspartate aminotransferase (AST, alanine aminotransferase (ALT and lactate dehydrogenase (LDH. Intra-arterial blood pressure was monitored continuously. Myeloperoxidase activity in the liver and lung was assessed 30 min after reperfusion. RESULTS: Plasma AST, ALT and LDH increased after reperfusion in all animals. Plasma ALT values and myeloperoxidase activity in the liver parenchyma were higher in HO-pretreated animals than in groups A, B and D. HO had a negative hemodynamic effect during liver reperfusion. CONCLUSION: Liver preconditioning with hyperbaric oxygen therapy aggravated liver ischemia/reperfusion injury in rats as demonstrated by plasma ALT and liver myeloperoxidase activity.OBJETIVO: Avaliar os efeitos da oxigenoterapia hiperbárica (OH como método preventivo da lesão de isquemia e reperfusão (LIR do fígado. MÉTODOS: Trinta e dois ratos machos Wistar foram distribuídos em quatro grupos de oito animais cada: A - laparotomia e manipulação hepática, B - isquemia e reperfusão hepática, C - pré-tratamento com OH por 60 minutos seguido de isquemia e reperfusão hepática e D - pré-tratamento com ar ambiente a 2,5 atmosferas absolutas por 60 minuto e isquemia e reperfusão hepática. Dosagens seriadas de AST, ALT e DHL foram realizadas. A pressão intra arterial foi monitorizada continuamente. O grau de infiltração leucocitária no fígado e pulmões foi inferido pela dosagem de mieloperoxidade

  6. Efeito da oxigenação hiperbárica em lesão ototóxica produzida pela amicacina em cobaias The effects of hyperbaric oxygen therapy upon ototoxic injuries produced by amikacin in guinea pigs

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    Luciana de Albuquerque Salviano Amora

    2013-06-01

    Full Text Available A oxigenação hiperbárica têm favorecido a prevenção e o tratamento de afecções auditivas como a ototoxicidade. OBJETIVO: Estudar os efeitos da oxigenação hiperbárica em lesão ototóxica promovida pela amicacina. Forma de estudo: Experimental. MÉTODO: Avaliados aspectos funcionais de 12 cobaias albinas por meio das emissões otoacústicas produtos de distorção e do potencial evocado auditivo de tronco encefálico, antes e após o uso de amicacina (600 mg/kg/dia e das sessões com oxigenação hiperbárica (2 ATA, 60 minutos. Aspectos morfológicos foram avaliados por meio de microscopia eletrônica de varredura. Grupos de estudo com três animais: grupo 1 - solução salina + oxigenação hiperbárica; grupo 2 - amicacina 8 dias; grupo 3 - amicacina + 7 dias de repouso e grupo 4 - amicacina + oxigenação hiperbárica. RESULTADOS: Grupo 1 apresentou preservação da funcionalidade e da morfologia durante todo experimento. Grupo 2 demonstrou, ao final do experimento, lesões estatisticamente significantes das células ciliadas com alterações funcionais. Grupos 3 e 4 apresentaram alterações estatisticamente significantes dos aspectos funcionais e morfológicos após o uso da amicacina, mantendo estas alterações após os procedimentos propostos. CONCLUSÃO: A oxigenação hiperbárica não promoveu alterações na morfologia das células ciliadas da cóclea e aos limiares eletrofisiológicos das cobaias submetidas à amicacina.Hyperbaric oxygen therapy (HBOT has enhanced the prevention and treatment of auditory ailments such as ototoxicity. OBJECTIVE: To study the effects of HBOT upon ototoxic injuries produced by amikacin. METHOD: This experimental study included 12 albino guinea pigs, whose auditory function was assessed through distortion product otoacoustic emissions (DPOAEs and brainstem auditory evoked potentials (BAEPs before and after the administration of amikacin (600 mg/kg/day and HBOT sessions (2 ATA, 60 minutes

  7. Atuação da enfermagem no tratamento com oxigenoterapia hiperbárica Actuación de la enfermería en el tratamiento con oxigenoterapia hiperbárica Nursing activities in hyperbaric oxygen therapy

    Directory of Open Access Journals (Sweden)

    Elias Pereira de Lacerda

    2006-02-01

    Full Text Available Através de relato de experiência desenvolvida na Clínica de Medicina Hiperbárica do Hospital Naval Marcílio Dias os autores discorrem sobre a atuação da enfermagem no tratamento com oxigenoterapia hiperbárica. Breve histórico do procedimento, efeitos terapêuticos, indicações, efeitos colaterais e complicações são apresentados. Entendem os autores que esforços devem ser envidados para que a atuação da enfermagem nesse novo papel seja conscientizada como alternativa de mercado de trabalho nesta especialidade que vem crescendo a cada dia.A través de un relato de experiencia desarrollada en la Clínica de Medicina Hiperbárica del Hospital Naval Marcílio Dias, los actores discurren sobre la actuación de la enfermería en el tratamiento con oxigenoterapia hiperbárica. Se presenta un breve histórico del procedimiento, efectos terapéuticos, indicaciones, efectos colaterales y complicaciones. Los autores consideran que son necesarios esfuerzos para que la actuación de la enfermería en ese nuevo papel sea concienciada como alternativa de mercado de trabajo en esta especialidad que viene creciendo a cada día.The authors discuss nursing activities in hyperbaric oxygen therapy through an experience report developed at the Medical Clinical of the Naval Hospital Marcílio Dias. This article presents a brief history of the procedure, its therapeutic effects, indications, collateral effects and complications. The authors believe that efforts are needed to create awareness about nursing activities in this new role as a labor market alternative in this growing specialty area.

  8. CLINICAL OBSERVATION OF ANTIBIOTIC IRRIGATION COMBINED WITH HYPERBARIC OXYGEN THERAPY IN THE TREATMENT OF OSTEOMYELITIS%抗生素灌洗疗法联合高压氧治疗骨髓炎的临床观察

    Institute of Scientific and Technical Information of China (English)

    潘勇泉; 刘志祥; 尚平; 杨俊龙; 赖震

    2015-01-01

    目的 观察抗生素灌洗疗法联合高压氧治疗骨髓炎的临床治疗效果. 方法 将62例慢性骨髓炎患者随机分为研究组和对照组,每组31例. 所有患者均反复清创,大量抗生素生理盐水灌注冲洗引流,同时进行长期抗生素控制. 研究组在此基础上应用高压氧治疗. 比较两组患者的治愈率、复发率、细菌检出率、抗生素应用时间、愈合时间、住院时间和炎症因子水平. 结果 研究组治愈率显著高于对照组(p0.05),治疗后研究组患者的IL-6和TNF-α水平均显著低于对照组( p0.05).After treatment, both of the IL-6 and TNF-αin in the experiment group were significantly less than those of the control group (p<0.01). Conclusion Antibiotic irrigation combined with hyperbaric oxygen therapy has a great clinical efficacy on osteomyeli-tis, and therefore is worthy of clinical application.

  9. 高压氧对急性脑梗死临床应用分析%CLINICAL APPLICATION OF HYPERBARIC OXYGENATION TO ACUTE CEREBRAL INFARCTION

    Institute of Scientific and Technical Information of China (English)

    邵伟波

    2002-01-01

    Objective:To determine the effect of hyperbaric oxygenation(HBO) on treating acute cerebral infarction(ACI). Methods: We randomly divided 60 patients with acute cerebral infarction into the treatment group and the control group. Hyperbaric oxygenation treatment was applied in the treatment group as routine drug therapy was used. The neurological function, living ability, clinical therapeutic effectiveness and hemorrheology changes of pa tients in the two groups before and after treatment were observed and evaluated. Results: The indexes of treatment were obviously improved one month after treatment (P < 0.05 ). Clinical effective rate was 93.3 % in this group,which was obviously higher than that of the control group(P < 0.05). Conclusion: Hyperbaric oxygenation can accelerate the recovery of neurological function of patients with acute cerebral infarction.

  10. Impact of Hyperbaric Oxygenation on Blood Anticolibacillary Activity in Hepatectomy

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    P. N. Savilov

    2007-01-01

    Full Text Available Objective: to study the anticolibacillary activity of arterial (aorta and venous (portal vein, hepatic veins blood during hepatectomy and hyperbaric oxygenation (HBO.Material and methods: Experiments were conducted on 40 non-inbred female albino rats exposed to hepatic resection (15—20% of organ mass and HBO at 3 ata for 50 min once daily within the first three days after surgery. The bactericidal action of blood serum against E.coli and the capacity of neutrophils and monocytes to absorb this microbe were investigated.Results: HBO prevents a hepatectomy-induced reduction in serum bactericidal activity in the portal venous blood, but its reduction in arterial blood remains. Along with this, hepatectomy-induced impairment in the capacity of the liver to stimulate the phagocytic activity of neutrophils and monocytes against E.coli is eliminated under HBO. The latter selectively stimulates the rate of venous blood neutrophilic absorption of E.coli, with this property being lowered in monocytes.Conclusion: HBO eliminates the body’s anticolibacillary defense impairments during hepatectomy. 

  11. Beneficial effect of hyperbaric oxygenation on liver regeneration in cirrhosis.

    Science.gov (United States)

    Ozdogan, Mehmet; Ersoy, Eren; Dundar, Kadir; Albayrak, Levent; Devay, Seda; Gundogdu, Haldun

    2005-12-01

    Underlying hepatic injury and cirrhosis are leading factors that interfere with the post-operative liver regeneration and function. Hyperbaric oxygenation (HBO) has been reported to ameliorate the ischemia-reperfusion injury of the liver, to induce compensatory hypertrophy of the predicted remnant liver in rats after portal vein ligation and to augment liver regeneration after hepatectomy in non-cirrhotic rats. Our aim was to determine the effect of HBO treatment on liver regeneration after partial hepatectomy in normal and cirrhotic mice in this experimental study. The effect of HBO on liver regeneration was studied in a mice model combining carbon tetrachloride induced cirrhosis and partial hepatectomy. Mice were divided into four groups: Control, cirrhotic, non-cirrhotic HBO-treated, and cirrhotic HBO-treated. All animals underwent 40% hepatectomy. Liver regeneration was evaluated by the proliferating cell nuclear antigen-labeling index. Serum aspartate aminotransferase and alanine aminotransferase levels were measured to evaluate liver injury. Serum alanine aminotransferase and aspartate aminotransferase levels were significantly decreased in HBO-treated cirrhotic group compared to cirrhosis group after hepatectomy (P = 0.001 and P = 0.014, respectively). The proliferating cell nuclear antigen labeling index was significantly higher in HBO treated cirrhotic group than in cirrhotic group after hepatectomy (P = 0.022). Our results suggest that HBO treatment improves liver functions and augments hepatocyte regeneration in cirrhotic mice after hepatectomy. Post-operative HBO treatment may have a beneficial effect on post-operative liver function and regeneration in cirrhotic patients.

  12. Hyperbaric oxygen preconditioning attenuates postoperative cognitive impairment in aged rats.

    Science.gov (United States)

    Sun, Li; Xie, Keliang; Zhang, Changsheng; Song, Rui; Zhang, Hong

    2014-06-18

    Cognitive decline after surgery in the elderly population is a major clinical problem with high morbidity. Hyperbaric oxygen (HBO) preconditioning can induce significant neuroprotection against acute neurological injury. We hypothesized that HBO preconditioning would prevent the development of postoperative cognitive impairment. Elderly male rats (20 months old) underwent stabilized tibial fracture operation under general anesthesia after HBO preconditioning (once a day for 5 days). Separate cohorts of animals were tested for cognitive function with fear conditioning and Y-maze tests, or euthanized at different times to assess the blood-brain barrier integrity, systemic and hippocampal proinflammatory cytokines, and caspase-3 activity. Animals exhibited significant cognitive impairment evidenced by a decreased percentage of freezing time and an increased number of learning trials on days 1, 3, and 7 after surgery, which were significantly prevented by HBO preconditioning. Furthermore, HBO preconditioning significantly ameliorated the increase in serum and hippocampal proinflammatory cytokines tumor necrosis factor-α, interleukin-1 β (IL-1β), IL-6, and high-mobility group protein 1 in surgery-challenged animals. Moreover, HBO preconditioning markedly improved blood-brain barrier integrity and caspase-3 activity in the hippocampus of surgery-challenged animals. These findings suggest that HBO preconditioning could significantly mitigate surgery-induced cognitive impairment, which is strongly associated with the reduction of systemic and hippocampal proinflammatory cytokines and caspase-3 activity.

  13. 高压氧联合甲钴胺治疗糖尿病周围神经病变的疗效%Effects of therapy of hyperbaric oxygen combined with mecobalamin on diabetic peripheral neuropathy

    Institute of Scientific and Technical Information of China (English)

    杨金华; 王金春; 金越

    2008-01-01

    目的 评价高压氧联合甲钴胺对糖尿病周围神经病变的疗效,探讨治疗糖尿病周围神经病变的有效方法.方法 378例糖尿病周围神经病变患者分为2组.治疗组198例,予高压氧联合甲钴胺治疗,高压氧疗法采用大型空气加压舱,治疗压力为0.2 Mpa(2.0 ATA),每日1次;甲钴胺500 μg,肌肉注射,每日1次.对照组180例,单独使用甲钴胺500 μg,肌肉注射,每日1次.2组患者疗程均为4周.结果 治疗组显效率、总有效率分别为40.9%和100%,明显高于对照组的17.3%及53.3%,2组间差异有统计学意义(P<0.01);治疗组神经传导速度及血流动力学改善均明显高于对照组(P<0.01).结论 高压氧联合甲钴胺对糖尿病周围神经病变的治疗效果显著,总有效率为100%,可作为糖尿病周围神经病变的常规治疗方法.%Objective To study effects of hyperbaric oxygen combined with mecobalamine on diabetic peripheral neuropathy(DPN)and explore effective therapeutic way to DPN.Methods Three hundred and seventy-eight patients.were divided into two groups.The treatment group(198 cases)were treated with hyperbaric oxygen(HBO)and mecobalamin(0.2 MPa,500 μg mecobalamin i.m.,once a day).The control group(180 cases)were only treated with 500 μg meeobalamin i.m.,once a day.Courses of treatment in two groups both were four weeks.Results The effective rate and overall efficacy rate of treatment group were 40.9% and 100%,respectively.They were significantly higher than those of control group(17.3% and 53.3%)(P<0.01).At the same time,there were obvious differences in nerve conduction velocity and dvnamics of blood flow between two groups(P<0.01).Conclusions HBO combined with mecobalamin has therapeutic effect on DPN,which may be regared as a conventional therapy.

  14. Combination hyperbaric oxygen and temozolomide therapy in c6 rat glioma model Terapia combinada de oxigênio hiperbárico e temozomida no modelo C6 de glioma em ratos

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    Yaşar Dagıstan

    2012-06-01

    Full Text Available PURPOSE: Temozolomide (TMZ has anti-tumor activity in patients with malignant glioma. Hyperbaric oxygen (HBO may enhance the efficacy of certain therapies that are limited because of the hypoxic tumor microenvironment. We examined the combined effects of TMZ-HBO in a rat glioma model. METHODS: After stereotactic injection of C6/LacZ rat glioma cells into the Wistar rats brain, the rats were randomly assigned to three treatment groups [group 1, control treatment; group 2, TMZ alone; group 3, a combination of TMZ and HBO]. Rats were sacrificed 18 days after treatment, and number of intra-/peri-tumoral vessels, microendothelial proliferations, immunohistochemistry and necrotic area were evaluated. RESULTS: Tumoral tissue was stained only sparsely with GFAP. Temozolomide treatment was significantly decreased in tumor tissue intratumoral vessel number / total tumor area level. The level of Ki67 was significantly decreased in the tumor tissue of the group 3. Additionally, the total necrotic area / total tumor volume (% was decreased significantly in tumor tissue of the group 3 rats compared to group1 and 2. CONCLUSION: The combination of hyperbaric oxygen with temozolomide produced an important reduction in glioma growth and effective approach to the treatment of glioblastoma.OBJETIVO: A temozolomida (TMZ tem atividade anti-tumoral em pacientes com glioma maligno. Oxigênio hiperbárico (HBO pode aumentar a eficácia de terapias que são limitadas devido a um microambiente do tumor hipóxico. Foram examinados os efeitos combinados de TMZ-HBO em um modelo de glioma em rato. MÉTODOS: Após a injeção estereotáxica de células de glioma de rato C6/LacZ no cérebro de ratos Wistar, os ratos foram distribuídos aleatoriamente em três grupos de tratamento: Grupo 1: tratamento de controle. Grupo 2: TMZ sozinho. Grupo 3: uma combinação de TMZ e HBO. Os ratos foram sacrificados 18 dias após o tratamento. Foram avaliados o número de vasos intra

  15. Optical Imaging of Tumor Response to Hyperbaric Oxygen Treatment and Irradiation in an Orthotopic Mouse Model of Head and Neck Squamous Cell Carcinoma

    NARCIS (Netherlands)

    J.A.M. Braks (Joanna); L. Spiegelberg (Linda); S. Koljenovic (Senada); Y. Ridwan (Yanto); S. Keereweer (Stijn); R. Kanaar (Roland); E.B. Wolvius (Eppo); J. Essers (Jeroen)

    2015-01-01

    textabstractPurpose: Hyperbaric oxygen therapy (HBOT) is used in the treatment of radiation-induced tissue injury but its effect on (residual) tumor tissue is indistinct and therefore investigated in this study. Procedures: Orthotopic FaDu tumors were established in mice, and the response of the (ir

  16. 高压氧治疗脑梗死疗效观察%Observation of therapeutic effect of hyperbaric oxygen on cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    马维艳; 杨丽

    2002-01-01

    Background:Hypoxia and ischemia resulting from cerebral infarction can further cause a series of pathological changes such as hydrocephallus.Drug therapy can improve cerebral blood circulation and enhance flow volume and decrease infarction area.If hyperbaric oxygen is added,pathophysiological changes such as ischemia and hypoxia can be improved and normal metabolism of brain cells be restored.

  17. Hyperbaric oxygen preconditioning induces tolerance against spinal cord ischemia in rabbits

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    DONG Hai-Long; XIONG Li-Ze; ZHU Zheng-Hua

    2000-01-01

    Objective To determine whether the ischemic tolerance could be induced in the spinal cord by pretreated with Hyperbaric oxygen (HBO). Methods 23 New Zealand white rabbits(2. 1 ±0.3Kg) were randomly assigned to three groups. Control Group: n=8,no hyperbaric oxygen was applied before spinal cord ischemia; HBO-1 Group: n=8,hyperbaric oxygen (2.5ATA, 100% O2, 1 hr per day) pretreated for 3 days before ischemia; HBO-2 Group: n=7, hyperbaric oxygen pretreated for 5 days before ischemia. Infrarenal aorta clamping modal was used in this study. Ischemia lasted for 20-min. MAP(proximal Distal)- HR、 PaO2、 PaCO2、 pH、 rectal temperature and plasma glucose were measured during experiment. Results The neurologic outcome both in HBO-1 and HE-2 Groups were better than that of Control Group (P<0.05). The neruologic outcome in HBO-2 was better than that of HBO-1 Group (P<0.05). The normal neurons in the anterior spinal cord of HBO-2 Group were more than that of Control and HBO-1 Groups.The number of normal neurons in the anterior spinal cord of HBO-1 Group was similar with that of Control Group. Conclusion hyperbaric oxygen preconditioning could induce ischemic tolerance on spinal cord in rabbits. 5 days period of HBO preconditioning induce stronger ischemic tolerance than 3 days of HBO preconditioning.

  18. The long-term outcomes of hyperbaric oxygen therapy in severe brain injury%高压氧治疗重型颅脑损伤的远期疗效

    Institute of Scientific and Technical Information of China (English)

    周世军

    2012-01-01

    To observe the long-term outcomes of hyperbaric oxygen(HBO) therapy in patients with severe brain injury. Methods A total of 120 patients with severe brain injury was equally divided into two groups of C( treated with conventional drugs and support therapy) and HBO (treated with additional HBO). The Glasgow coma scale (GCS) of all cases was ≤8 points at admission. The patients of two groups were similar in basic conditions and were followed up for 12 months. The long-term outcomes were evaluated by Glasgow outcome scate(GOS) and disability rating scale(DRS). Results Compared to group C after treated for 12 months, in group HBO the mortality was lower(30, 0% vs. 50, 0%), well recovery rate was higher (53-3% vs, 25.0%) and DRS was lower[(15. 5 + 2. 2) points vs. (18. 3±2. 5) points](F<0. 01 or P<0. 05). Conclusion On the basis of conventional therapy,additional HBO treatment can effectively improve the long-term outcomes in the patients with severe brain injury.%目的 观察高压氧(HBO)治疗重型颅脑损伤的远期疗效.方法 重型颅脑损伤120例均分为基本资料相仿的两组:对照组采用常规药物和支持疗法;HBO组加用HBO治疗.随访12个月,采用格拉斯哥预后评分(GOS)和严重颅脑外伤残疾评定量表(DRS)评定疗效.结果 伤后12个月,HBO组患者病死率明显低于对照组(30.0% vs.50.0%)(P<0.01),恢复良好率高于对照组(53.3% vs.25.0%)(P<0.01).HBO组患者DRS评分明显低于对照组[(15.5±2.2)分vs.(18.3±2.5)分](P<0.05).结论 在常规治疗的基础上加用HBO治疗能显著改善重型颅脑损伤患者的远期预后.

  19. Hyperbaric oxygen treatment augments tobramycin efficacy in experimental staphylococcus aureus endocarditis

    DEFF Research Database (Denmark)

    Lerche, C J; Christophersen, L J; Kolpen, M

    2017-01-01

    BACKGROUND: S. aureus infective endocarditis (IE) is a serious disease an in-hospital mortality of up to 40%. Improvements of effects of antibiotics and host responses could potentially benefit outcomes. Hyperbaric oxygen treatment (HBOT) represents an adjunctive therapeutic option. We evaluated...... the efficacy of HBOT in combination with tobramycin in S. aureus IE. METHODS: A rat model of S. aureus IE mimicking the bacterial load in humans was used. Infected rats treated with tobramycin were randomized into two groups, 1) HBOT (b.i.d) or 2) normobaric air breathing (non-HBOT). Quantitative bacteriology......: HBOT augmented tobramycin efficacy as assessed by several parameters. The present findings suggest the potential use of adjunctive therapy in severe S. aureus IE....

  20. Hyperbaric oxygen therapy of encephalopathy tarda induced by CO intoxication%一氧化碳中毒迟发脑病的高压氧治疗

    Institute of Scientific and Technical Information of China (English)

    杨金华; 王金春

    2003-01-01

    @@ INTRODUCTION Encephalopathy tarda of CO intoxication is the result of incomplete therapy or in- timely treatment of acut intermedium or severe CO intoxication leading to a series of nerve system injury.Due to long period of course,serious condition and unlcrear mechanism,therapy is difficult and poor effect.

  1. Exposure to Hyperbaric Oxygen Intensified Vancomycin-Induced Nephrotoxicity in Rats.

    Science.gov (United States)

    Sabler, Itay M; Berkovitch, Matitiahu; Sandbank, Judith; Kozer, Eran; Dagan, Zahi; Goldman, Michael; Bahat, Hilla; Stav, Kobi; Zisman, Amnon; Klin, Baruch; Abu-Kishk, Ibrahim

    2016-01-01

    It has been suggested that oxidative stress is a potential mechanism for vancomycin-induced nephrotoxicity and hyperbaric oxygen therapy (HBO) has been shown to be effective in treating renal toxicity that has been pharmacologically induced in animal models. The aim of this study was to investigate the effect of HBO therapy on vancomycin-induced nephrotoxicity in rats. The study group comprised 36 Sprague Dawley male rats. We treated 30 with 500 mg/kg of intraperitoneal vancomycin once a day for 7 days. Half of these rats received a daily 1-hour treatment with HBO at 2 Atmospheres (ATM) on the same 7 days and formed the HBO+ group. The other 15 subjects received no HBO treatment (HBO- group). The remaining six rats served as the control group, three received HBO treatments alone and no treatment was administered to the other three rats. Laboratory results were obtained on day 8 and the intervention and control groups were compared. Rats in the HBO+ group gained less weight than the HBO- group (11.6 grams vs 22.6 grams; P = 0,008) and had significantly higher serum blood urea nitrogen (99.6 vs 52.6 mg/dL; Pvancomycin blood levels were also higher in the HBO+ group (27.8 vs 6.7 μg/mL; P = 0.078). There were no pathological kidney changes in the control group. All the kidneys from the treated groups (vancomycin +HBO and vancomycin HBO-) showed moderate to severe histopathological changes with no statistical significance between them. This study demonstrated that exposure to hyperbaric oxygen intensified vancomycin-induced nephrotoxicity in rats.

  2. Effects of heparin and hyperbaric oxygenation on necrosis reduction in an animal model for degloving injuries.

    Science.gov (United States)

    Menon, Douglas Neumar; Teixeira, Letícia; Paurosi, Natalha Bristot; Barros, Marcio Eduardo

    2017-01-01

    to evaluate the efficacy of the treatment with hyperbaric oxygen therapy or with topical and intralesional heparin in an animal model of degloving lesions. we conducted an experimental study with adult, male Wistar rats submitted to degloving of the left hind limb and divided into four groups according to the treatment: Group 1 (control) - without treatment; Group 2 (Heparin) - intralesional application at the time of surgery and topically, in the postoperative period, with heparin spray 10,000IU/mL; Group 3 (hyperbaric oxygenation) - daily sessions of 30 minutes in a hyperbaric chamber with 100% oxygen and 2 ATA pressure; Group 4 (positive control) - administration of a single dose of 45 mg/kg of intraperitoneal allopurinol. On the seventh day, we killed the animals, removed the cutaneous flaps and measured the total and necrotic areas, as well as computed the percentage of necrotic area. the mean percentage of necrosis in the control group was 56.03%; in the positive control group it was 51.36% (pgrupos, de acordo com o tratamento: Grupo 1 (controle) - sem tratamento; Grupo 2 (Heparina) - aplicação intralesional no momento da cirurgia e tópica, no pós operatório, com spray de heparina 10.000UI/mL; Grupo 3 (oxigenação hiperbárica) - sessões diárias de 30 minutos em câmara hiperbárica com 100% de oxigênio e 2 ATA de pressão; Grupo 4 (controle positivo) - administração de dose única de 45mg/kg de alopurionol intraperitoneal. No sétimo dia os animais foram mortos e os retalhos cutâneos foram retirados e realizadas medidas das áreas total e necrótica, bem como cálculo da porcentagem da área de necrose. a média da porcentagem de necrose do grupo controle foi 56,03%; no grupo controle positivo, 51,36% (p≤0,45); no grupo da heparina, 42,10% (p≤0,07) e no grupo da oxigenoterapia hiperbárica, 31,58% (p≤0,01). tanto a oxigenoterapia hiperbárica quanto a terapia com heparina mostraram-se eficazes na redução do percentual de necrose no modelo

  3. Long Course Hyperbaric Oxygen Stimulates Neurogenesis and Attenuates Inflammation after Ischemic Stroke

    Directory of Open Access Journals (Sweden)

    Ying-Sheng Lee

    2013-01-01

    Full Text Available Several studies have provided evidence with regard to the neuroprotection benefits of hyperbaric oxygen (HBO therapy in cases of stroke, and HBO also promotes bone marrow stem cells (BMSCs proliferation and mobilization. This study investigates the influence of HBO therapy on the migration of BMSCs, neurogenesis, gliosis, and inflammation after stroke. Rats that sustained transient middle cerebral artery occlusion (MCAO were treated with HBO three weeks or two days. The results were examined using a behavior test (modified neurological severity score, mNSS and immunostaining to evaluate the effects of HBO therapy on migration of BMSCs, neurogenesis, and gliosis, and expression of neurotrophic factors was also evaluated. There was a lower mNSS score in the three-week HBO group when compared with the two-day HBO group. Mobilization of BMSCs to an ischemic area was more improved in long course HBO treatments, suggesting the duration of therapy is crucial for promoting the homing of BMSCs to ischemic brain by HBO therapies. HBO also can stimulate expression of trophic factors and improve neurogenesis and gliosis. These effects may help in neuronal repair after ischemic stroke, and increasing the course of HBO therapy might enhance therapeutic effects on ischemic stroke.

  4. Reversibility of retinal ischemia due to central retinal artery occlusion by hyperbaric oxygen

    Directory of Open Access Journals (Sweden)

    Hadanny A

    2016-12-01

    Full Text Available Amir Hadanny,1,2 Amit Maliar,1 Gregory Fishlev,1 Yair Bechor,1 Jacob Bergan,1 Mony Friedman,1 Isaac Avni,2,3 Shai Efrati1,2,4,5 1Sagol Center for Hyperbaric Medicine and Research, Assaf Harofeh Medical Center, Zerifin, Israel; 2Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel; 3Opthalmology Department, Assaf Harofeh Medical Center, Zeirifin, Israel; 4Research and Development Unit, Assaf Harofeh Medical Center, Zerifin, Israel; 5Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel Purpose: Ischemic retinal damage can be reversed by hyperbaric oxygen therapy (HBOT as long as irreversible infarction damage has not developed. However, the time window till irreversible damage develops is still unknown. The study aim was to evaluate the effect of HBOT and determine possible markers for irreversible retinal damage.Materials and methods: Retrospective analysis of 225 patients treated with HBOT for central retinal artery occlusion (CRAO in 1999–2015. One hundred and twenty-eight patients fulfilled inclusion/exclusion criteria: age >18 years, symptoms <20 hours, and best-corrected visual acuity (BCVA <0.5 logMAR.Results: Time delay from symptoms to treatment was 7.8±3.8 hours. The BCVA was significantly improved after HBOT, from 2.14±0.50 to 1.61±0.78 (P<0.0001. The proportion of patients with clinically meaningful visual improvement was significantly higher in patients without cherry-red spot (CRS compared to patients with CRS at presentation (86.0% vs 57.6%, P<0.0001. The percentage of patients with final BCVA better than 1.0 was also significantly higher in patients without CRS vs patients with CRS at presentation (61.0% vs 7.1%, P<0.0001. There was no correlation between CRS and the time from symptoms. HBOT was found to be safe, and only 5.5% of patients had minor, reversible, adverse events.Conclusion: HBOT is an effective treatment for non-arteritic CRAO as long as CRS has not formed. The fundus findings, rather

  5. Effect of Liver Damage and Hyperbaric Oxygenation on Glutamine Synthetase of Hepatocytes.

    Science.gov (United States)

    Savilov, P N; Yakovlev, V N

    2016-01-01

    Activity of glutamine synthetase in the hepatocytes of healthy animals and animals with chronic CCl4-induced hepatitis was studied on white mature female rats after liver resection (15-20% of organ weight) and hyperbaric oxygenation (3 atm, 50 min, 3 times). Surgically operated left and non-operated middle lobes of the liver were analyzed on day 3 after liver resection and exposure to hyperbaric oxygenation. On day 65 of CCl4 poisoning, activity of glutamine synthetase decreased in both lobes and did not recover on day 3 after toxin cessation. Liver resection under conditions of CCl4-induced hepatitis restored reduced activity of glutamine synthetase in both liver lobes to the normal level. In healthy rats, the increase in glutamine synthetase activity after liver resection was found only in the middle lobe of the liver. Hyperbaric oxygenation enhanced the stimulatory effect of liver resection on glutamine synthetase activity in hepatocytes during chronic CCl4-induced hepatitis. In healthy animals with liver resection, activity of glutamine synthetase did not change after hyperbaric oxygenation, while normally oxygenation inhibited glutamine synthetase activity.

  6. The Effect of Postoperative Hyperbaric Oxygen Treatment on Intra-Abdominal Adhesions in Rats

    Directory of Open Access Journals (Sweden)

    Yi-Chiang Hsu

    2012-09-01

    Full Text Available Abdominal adhesions, whether caused by peritoneal trauma, radiation, infection, or a congenital condition, are associated with a wide range of complications. These complications include chronic abdominal or pelvic pain, infertility, and adhesive small bowel obstruction. Such adhesions render re-operation difficult, with attendant risks of inadvertent enterostomy and increased operation time. The purpose of this study was to investigate the potential of hyperbaric oxygen (HBO therapy in the prevention of abdominal adhesions in an experimental animal study. A laparotomy was performed on Wistar rats to induce the formation of adhesions on the cecum and the intra-abdominal area (1 ´ 2 cm. A superficial layer of the underlying muscle from the right abdominal wall was also shaved and prepared for aseptic surgery. The rats were divided into four groups according to the duration of HBO therapy; five additional groups were designated according to the conditions of HBO therapy. When the rats were evaluated according to adhesion area and grade, a statistically significant difference was observed between the control and HBO treatment groups (p < 0.005. Results from this study suggest that HBO treatment could reduce adhesion formation; and further suggest that HBO therapy may have therapeutic potential in the treatment of postoperative peritoneal adhesion.

  7. Oxygen Therapy

    Science.gov (United States)

    ... oxygen at very high altitudes (like in the mountains or in an airplane) even if you do ... Med Vol 171. P1-P2, 2005 ATS Patient Education Series © 2016 American Thoracic Society www. thoracic. org ...

  8. Cognitive Function in a Traumatic Brain Injury Hyperbaric Oxygen Randomized Trial

    Science.gov (United States)

    2015-08-07

    Hyperbaric oxygen (HBO2) is an adjunctive treat- ment for indications such as delayed radiation injury, central retinal artery occlusion, sudden...use in treating carbon monoxide poisoning and resultant acute cerebral injury and delayed neuropsychiatric syndrome [8]. In 2008, we developed...oxygen dose represented as meters of mercury minutes or mHg*min (Wolf). This is the same concept used in radiation oncology, where a total dose is

  9. MRS research of hyperbaric oxygen therapy in rabbits after explosive brain injury%实验性兔颅脑爆炸伤后高压氧治疗作用的磁共振波谱研究

    Institute of Scientific and Technical Information of China (English)

    杨艳艳; 刘家传; 张永明; 孙文江; 汤宏; 黄振山; 李兵仓; 张良潮

    2011-01-01

    目的 利用磁共振波谱技术(MRS)探讨高压氧治疗对颅脑爆炸伤时脑局部代谢变化的影响.方法 新西兰大白兔100只随机分成对照组、创伤组和高压氧治疗组.采用600 mg TNT当量纸雷管在兔脑上方6.5 cm垂直距离爆炸以建立颅脑爆炸伤模型.对照组无损伤,创伤组爆炸伤后不进行任何治疗,高压氧治疗组于伤后行高压氧治疗.观察爆炸伤后各组兔的生理改变,采用MRS计算并分析各组不同时相点乙酰天门冬氨酸(NAA)/肌酸(Cr)、胆碱(Cho)/Cr的比值,分析比较各组脑组织含水量的变化.结果 成功复制兔颅脑爆炸伤模型.与对照组相比,创伤组兔NAA/Cr比值伤后24 h明显下降(P<0.05),7 d后有所回升,14 d后再次下降(P<0.05);高压氧治疗组NAA/Cr比值下降较创伤组延迟,且幅度小.创伤组Cho/Cr比值伤后12 h明显升高,24 h下降,伤后3~14 d逐渐升高;高压氧治疗组Cho/Cr比值较创伤组升高,但7 d后无统计学差异.与对照组比较,创伤组、高压氧治疗组损伤或治疗1 h~7d后脑组织含水量均明显升高(均P<0.05).结论 高压氧可改善局部神经元代谢,抑制脑水肿,增强局部胶质细胞增生修复.伤后7 d内干预可能有助于改善预后.%Objective To investigate the effect of hyperbaric oxygen (HBO) therapy on local metabolic changes in the brain after explosive brain injury by magnetic resonance spectroscopy (MRS). Methods A hundred New Zealand white rabbits were divided into the control group, injury group and HBO therapy group randomly. The rabbits were injured by 600 rag TNT equivalent of paper detonators, which exploded at 6.5 cm distance over the rabbit head, as explosive injury model in the injury and HBO therapy groups,and no explosive injury was performed in the control group. The rabbits in HBO therapy group received HBO therapy after explosive injury. The pathophysiological changes of the rabbits were observed after explosive injury in the

  10. The effect observation of early hyperbaric oxygen combined music therapy on brain trauma coma wake and prognosis%早期高压氧联合音乐疗法对脑外伤昏迷促醒及预后的效果

    Institute of Scientific and Technical Information of China (English)

    黄的; 徐斌

    2016-01-01

    目的:观察早期高压氧联合音乐疗法对脑外伤昏迷促醒率及预后程度。方法:将170例脑外伤昏迷的患者,随机分为对照组和观察组,各85例。对照组给予常规药物治疗及康复护理,观察组在此基础上给予高压氧及音乐疗法,随访6个月,比较两组患者清醒时间及格拉斯哥预后结局量表(Glasgow outcome scale,GOS)等级情况。结果:两组患者的清醒时间及格拉斯哥预后结局等级比较,差异有统计学意义( P <0.05)。结论:早期高压氧联合音乐疗法对脑外伤昏迷促醒有较好的临床疗效,而且能减轻后遗症。%Objective:To observe the effect of early hyperbaric oxygen combined music therapy on brain trauma coma wake and prognosis. Nethods:170 cases of brain injury coma were randomly divided into control group(85 cases)and observation group(85cases). The control group was given conventional drugs and rehabilitation nursing,and the observation group with music therapy and hyperbaric oxygen treatment. After active treatment and follow - up for six months,the awake time,and Glasgow Outcome Scale for prognostic outcomes in the two groups were compared. Results:The comparison of awake time,and Glasgow Outcome Scale for prognostic outcomes between the two groups difference was statistically sig-nificant( P < 0. 05). Conclusion:Early hyperbaric oxygen combined music therapy on brain injury coma wake has better clinical curative effect, and can reduce sequel.

  11. Multiple hyperbaric oxygenation (HBO) expands the therapeutic window in acute spinal cord injury in rats.

    Science.gov (United States)

    Huang, L; Mehta, M P; Eichhorn, J H; Nanda, A; Zhang, J H

    2003-01-01

    Hyperbaric oxygenation (HBO) therapy has been reported to improve neurological recovery following spinal cord injury (SCI). In the present study, we examined whether multiple HBO expands the therapeutic window for acute SCI. Single HBO (2.8 ATA, 1 hour) treatment was used at 30 minutes, 3 hours, and 6 hours following SCI, and serial HBO treatment (once daily for 1 week) at 6 hours and 24 hours post-injury. Mild SCI was induced by adjusting the height for a weight drop insult (10 g) to 6.25 mm above the exposed spinal cord. The group of animals receiving a single HBO intervention beginning at 30 minutes and 3 hours, or serial HBO treatment starting at 6 hours following the injury had a significantly better neurological recovery than animals with SCI only. The results of this study demonstrate that multiple HBO expands the therapeutic window for acute SCI to 6 hours after injury, further that serial HBO administration is superior to single HBO therapy.

  12. Effects of Repetitive Hyperbaric Oxygen Treatment in Patients with Acute Cerebral Infarction: A Pilot Study

    Directory of Open Access Journals (Sweden)

    Cheng-Hsin Chen

    2012-01-01

    Full Text Available The role of hyperbaric oxygen therapy (HBOT in the treatment of acute ischemic stroke is controversial. This prospective study assessed the efficacy and safety of HBOT as adjuvant treatment on 46 acute ischemic stroke in patients who did not receive thrombolytic therapy. The HBOT group (n=16 received conventional medical treatment with 10 sessions of adjunctive HBOT within 3–5 days after stroke onset, while the control group (n=30 received the same treatment but without HBOT. Early (around two weeks after onset and late (one month after onset outcomes (National Institutes of Health Stroke Scale, NIHSS scores and efficacy (changes of NIHSS scores of HBOT were evaluated. The baseline clinical characteristics were similar in both groups. Both early and late outcomes of the HBOT group showed significant difference (P≤0.001. In the control group, there was only significant difference in early outcome (P=0.004. For early efficacy, there was no difference when comparing changes of NIHSS scores between the two groups (P=0.140 but there was statistically significant difference when comparing changes of NIHSS scores at one month (P≤0.001. The HBOT used in this study may be effective for patients with acute ischemic stroke and is a safe and harmless adjunctive treatment.

  13. Effect of hyperbaric oxygen therapy on esophagojejunal anastomosis healing in rats O efeito da oxigenoterapia hiperbárica na cicatrização da anastomose esofagojejunal em ratos

    Directory of Open Access Journals (Sweden)

    João Domingos Lionço

    2008-12-01

    Full Text Available PURPOSE: To evaluate hyperbaric oxygen therapy (HBO after esophagojejunal anastomosis in a rat experimental model and the effect of HBO on the healing of esophagojejunal anastomosis in gastrectomized rats. METHODS: Forty adult male Wistar rats, weighing 322 g to 506 g, were divided into two random groups. In group A (control group, 20 rats were subjected to total gastrectomy. In group B, 20 rats were similarly gastrectomized, but also received postoperative HBO treatment for 90 minutes/day for seven days. All rats were sacrificed on the eighth postoperative day and evaluated according to the following study variables: a presence of anastomotic fistula; b evaluation of esophagojejunal anastomosis healing by measuring the breaking strength at the suture line as per Hendriks & Mastboom; and c determining the collagen concentration in the anastomosis, as per Kovács criteria. For the comparative statistical analysis between groups, Student's "t" test was used. A value of pOBJETIVO: Avaliar o efeito da oxigenoterapia hiperbárica na cicatrização da anastomose esôfagojejunal em ratos gastrectomizados. MÉTODOS: 40 ratos Wistar, adultos machos, pesando entre 322g e 506g, foram divididos aleatoriamente em dois grupos. No grupo A (grupo controle 20 ratos foram submetidos à gastrectomia total. No grupo B, 20 ratos foram gastrectomizados e receberam tratamento pós-operatório com oxigênio hiperbárico, 90 minutos/dia durante sete dias. Todos os ratos foram sacrificados no oitavo dia pós-operatório e avaliados de acordo com as seguintes variáveis: a presença de fístula anastomótica; b avaliação da cicatrização da anastomose esôfagojejunal pela medida da força de ruptura à tração na linha da sutura conforme Hendriks & Mastboom; c determinação da concentração de colágeno na anastomose pelos critérios de Kovács. Para análise estatística comparativa entre os grupos foi utilizado o teste "t" de Student, considerando-se como

  14. 高压氧综合治疗中、重度颅脑外伤68例%Effect of hyperbaric oxygen in the treatment of moderate and severe head trauma in 68 cases

    Institute of Scientific and Technical Information of China (English)

    周宏图; 王建宏; 袁建国; 张雪春

    2003-01-01

    @@ INTRODUCTION Neurotrophic drugs,resting treatment,and proper physical therapy are generally suggested for rehabilitation after head trauma.In recent years,hyperbaric oxygen a new,safe and effective therapy had been used for rehabilitation following head trauma,which is safe,and effective.

  15. Investigation of endocrine and immunological response in fat tissue to hyperbaric oxygen administration in rats.

    Science.gov (United States)

    Şen, H; Erbağ, G; Ovali, M A; Öztopuz, R Ö; Uzun, M

    2016-04-30

    Though HBO treatment is becoming more common, the mechanism of action is not fully known. The positive effects of HBO administration on the inflammatory response is thought to be a possible basic mechanism. As a result, we aimed to research whether endocrine and immunological response of fat tissue changes in rats given HBO treatment model. This research was carried out on Wistar albino rats, they were treated with hyperbaric oxygen therapy. Their fatty tissue were taken from the abdomen, gene expression of the cytokines and adipokines were analyzed with Real time PCR method. When the gene expression of hormones and cytokines by fat tissue was examined, the leptin, visfatin, TNF-α, IL-1β and IL-10 levels in the HBO treatment group were statistically significantly increased compared to the control group (p=0.0313, p=0.0156, p=0.0156, p=0.0156, p=0.0313). In conclusion, in our study we identified that HBO administration affected the endochrinological functions of fat tissue.

  16. Impact of Hyperbaric Oxygenation on the Phagocytosis-Stimulating Function of the Operated Liver

    OpenAIRE

    Savilov, P. N.

    2008-01-01

    Objective: to study the ability of hyperbaric oxygenation (HBO) to eliminate impaired phagocytosis-stimulating hepatic function caused by hepatectomy (HE). Material and methods. Experiments were conducted on 82 outbred female albino rats exposed to HE (15—20% of the organ mass) and HBO at 3 ata for 50 min once daily three times within the first three days after surgery. The capacities of neutrophils and monocytes of arterial (aorta) and venous (portal vein, hepatic veins) blood to ingest and ...

  17. Home Oxygen Therapy

    Science.gov (United States)

    ... Teenagers Living With Lung Disease Articles written by Respiratory Experts Home Oxygen Therapy More and more people are using oxygen therapy ... April 12, 2012 Revised: © 2017 American Association for Respiratory Care

  18. Effects of hyperbaric oxygen and Pgg-glucan on ischemic colon anastomosis

    Institute of Scientific and Technical Information of China (English)

    Suna Guzel; Oguzhan Sunamak; Abdullah AS; Varol Celik; Mehmet Ferahman; Muhammed MK Nuri; Ertugrul Gazioglu; Pinar Atukeren; Ozgur Mutlu

    2006-01-01

    AIM: In colorectal surgery, anastomotic failure is still a problem in ischemia. Here, we analyzed the effects of hyperbaric oxygen and beta-glucan on colon anastomoses in ischemic condition.METHODS: Colonic resection and anastomosis in rectosigmoid region were done in forty Wistar-Albino rats of four groups of equal number. Colon mesentery was ligated to induce ischemia. The first group was the control group. The subjects of second group were treated with hyperbaric oxygen; the third group with glucan and the forth group were treated with both. At the forth day, rats were sacrificed, anastomotic segment was resected and burst pressures and hydroxyproline levels of anastomotic line were measured.RESULTS: The burst pressure difference of second and third groups from the control group were meaningful (P< 0.01); the forth group differed significantly from the control (P<0.001). There was no difference between the treated groups on burst pressure level (P> 0.05).The hydroxyproline levels in all treated groups were different from the control group significantly (P< 0.001).Hydroxyproline levels in the forth group were higher than those of the second and the third groups (P< 0.001).There were no significant differences between the second and the fourth groups in burst pressure and hydroxyproline levels (P> 0.05).CONCLUSION: Hyperbaric oxygen and glucan improve healing in ischemic colon anastomoses by anti-microbic,immune stimulating properties and seem to act synergistically when combined together.

  19. Case report: Hyperbaric oxygen in the treatment of puff adder (Bitis arietans) bite.

    Science.gov (United States)

    Rainer, Peter P; Kaufmann, Peter; Smolle-Juettner, Freyja M; Krejs, Guenter J

    2010-01-01

    The puff adder (Bitis arietans) is a venomous viper mainly found in sub-Saharan Africa. Due to its common occurrence and potent venom, it is considered to be the most dangerous snake in Africa, responsible for most snakebite fatalities there. Puff adder bites outside Africa are rare and involve captive vipers. We present the unusual case of puff adder envenomation in an Austrian man. A 26-year-old Austrian man was bitten by a puff adder that he kept illegally in his home. On admission he showed signs of local and systemic toxicity. He was stabilized with antivenom, intravenous fluids, catecholamines and packed platelets. Hyperbaric oxygenation was begun due to incipient compartment syndrome on the second day and continued until the eleventh day, when the patient had recovered completely and could be discharged. The venom of Bitis arietans can cause serious systemic and local complications. Our patient suffered from both. Systemic signs included hemodynamic as well as hemostaseologic impairment. Local effects included swelling and incipient compartment syndrome. Systemic and local treatment, including hyperbaric oxygenation, effected a full recovery. We suggest that, whenever feasible, hyperbaric oxygenation should be considered as adjunct treatment in snake bites to avert adverse outcomes.

  20. Effect of hyperbaric oxygen on mesenchymal stem cells for lumbar fusion in vivo

    Directory of Open Access Journals (Sweden)

    Lin Song-Shu

    2010-03-01

    Full Text Available Abstract Background Hyperbaric oxygen (HBO therapy has been proved in improving bone healing, but its effects on mesenchymal stem cells (MSCs in vivo is not clear. The aims of this study are to clarify whether the HBO therapy has the same enhancing effect on MSCs with regard to bone formation and maturation and to ascertain whether the transplanted MSCs survive in the grafted area and contribute to new bone formation. Methods Twenty-three adult rabbits underwent posterolateral fusion at L4-L5 level. The animals were divided into three groups according to the material implanted and subsequent treatment: (1 Alginate carrier (n = 6; (2 Alginate-MSCs composite (n = 11; and (3 Alginate-MSCs composite with HBO therapy (n = 6. After 12 weeks, spine fusion was examined using radiographic examination, manual testing, and histological examination. Using a PKH fluorescence labeling system, whether the transplanted MSCs survived and contributed to new bone formation in the grafted area after HBO therapy was also examined. Results The bilateral fusion areas in each animal were evaluated independently. By radiographic examination and manual palpation, union for the Alginate, Alginate-MSCs, and Alginate-MSCs-HBO groups was 0 of 12, 10 of 22, and 6 of 12 respectively. The difference between the Alginate-MSCs and Alginate-MSCs-HBO groups was not significant (P = 0.7997. The fluorescence microscopy histological analysis indicated that the transplanted PKH67-labeled MSCs survived and partly contributed to new bone formation in the grafted area. Conclusions This study demonstrated that the preconditioned MSCs could survive and yield bone formation in the grafted area. HBO therapy did not enhance the osteogenic ability of MSCs and improve the success of spine fusion in the rabbit model. Although there was no significant effect of HBO therapy on MSCs for spine fusion, the study encourages us to research a more basic approach for determining the optimal oxygen tension

  1. Observation of the Therapeutic Effect of Ginaton with Hyperbaric Oxygen Therapy for Sudden Deafness in 42 Cases%金纳多配合高压氧治疗突发性耳聋42例疗效观察

    Institute of Scientific and Technical Information of China (English)

    谢绍欣

    2011-01-01

    目的 观察金纳多配合高压氧治疗突发性耳聋的疗效.方法 将我院83例突发性耳聋患者随机分为两组,对照组:10%低分子右旋糖酐注射500 mL+地塞米松10 mg+能量合剂,静脉滴注,1次/d.同时辅以高压氧治疗60 min,1次/d.口服谷维素片、西比灵各2片,3次/d,20 d为1个疗程.治疗组:在对照组治疗的基础上加用金纳多注射液17.5 mg×5支加入5%葡萄糖液250 mL,静脉滴注,1次/d,20 d为1个疗程.观察治疗前后两组患者耳聋、耳鸣、眩晕好转程度及纯音测听复查情况,并进行比较.结果 治疗组临床有效率为90.48%,对照组为68.29%.两组疗效比较差异有统计学意义(P<0.01).结论 金纳多配合高压氧治疗突发性聋疗效好,患者耳聋、耳鸣、眩晕明显得到改善,值得临床上推广使用.%Objective To observe the therapeutic effect of ginaton with hyperbaric oxygen treatment for sudden deafness. Methods 83 cases of sudden deafness accepted in our hospital were randomly divided into two groups, control group :41 cases, treated with 10% dextran injection 500 mL + dexamethasone 10 mg + energy mixture,ntravenous infusion, 1 time/d,supplemented by high-pressure oxygen treatment 60 min,l time/ d,oral-taken oryzanol,flunarizine two pills each time respectively,3 times/ d,20 days as a treatment course. Treatment group:on the basis of control group plus ginaton injection 17.5 mg x5 in 5% glucose 250 mL,intravenous infusion, 1 time/d,20 days as a treatment course. The two groups were observed before and after treatment in terms of deafness,tinnitus,vertigo improved degree and pure tone audiometry review. Results Clinical efficacy of the treatment group was 90.48% ,and68.29% of the control group, which was statistically significant( P <0.01 ). Conclusion Ginaton with hyperbaric oxygen treatment for sudden deafness is effective ,where obvious improvement in deafness, tinnitus and vertigo is observed, which is worthy of clinical popularization.

  2. Comparison of two different steroid treatments with hyperbaric oxygen for idiopathic sudden sensorineural hearing loss.

    Science.gov (United States)

    Sevil, Ergun; Bercin, Sami; Muderris, Togay; Gul, Fatih; Kiris, Muzaffer

    2016-09-01

    The purpose of the study was to assess the efficacy of the association of intratympanic (IT) steroid and hyperbaric oxygen (HBO) therapy in patients presenting with idiopathic sudden sensorineural hearing loss (ISSNHL), and to compare this protocol with another consisting of intravenous (IV) steroid administration and HBO therapy. A total of 80 patients diagnosed with ISSNHL were included in this prospective trial. Patients were divided into three categories: a mild-to-moderate ISSNHL group with a pure-tone average (PTA) ≤60 decibels (dB), a severe ISSNHL group with a PTA of 60-80 dB, and a profound ISSNHL group with a PTA ≥81 dB. The first protocol consisted of 20 sessions of HBO therapy together with IV methylprednisolone 1 mg/kg body weight and a 10 mg taper every 3 days for 10 days. The second protocol consisted of HBO therapy for 20 sessions, together with an IT injection of dexamethasone at a dose of 4 mg/mL, 0.5-0.7 mL once a day for 7 consecutive days, performed 3 h before the HBO therapy. In the mild-to-moderate ISSNHL patients, the mean hearing gain and successful treatment rate was 19 (0-27) dB and 78.9 %, respectively in the IT + HBO treatment group, and 18 (3-44) dB and 70.5 % in the IV + HBO therapy group. In the severe ISSNHL patients, the mean hearing gain and successful treatment rate was 33 (1-54) dB and 81.8 %, respectively in the IT + HBO treatment group and 33.5 (7-57) dB and 58.2 % in the IV + HBO group. In the profound ISSNHL patients, the mean hearing gain and successful treatment rate was 36 (4-69) dB and 40 %, respectively in the IT + HBO therapy group, and 39.5 (0-92) dB and 72.7 % in the IV + HBO treatment group. The results demonstrated that patients with severe hearing loss success rate was superior in the group submitted to IT + HBO treatment, conversely IV + HBO therapy may be benefit for patients with profound hearing loss. Nevertheless, these clinical results were not statistically significant.

  3. Therapeutic effect of hyperbaric oxygen in psoriasis vulgaris: two case reports and a review of the literature

    OpenAIRE

    2009-01-01

    Abstract Introduction Psoriasis is an inflammatory and immunological cutaneous disease. The high morbidity in patients with psoriasis results from severe clinical manifestations and/or adverse effects of treatment. The Undersea and Hyperbaric Medical Society and Federal Medicare and Medicaid Services have approved the use of hyperbaric oxygen (HBO2) for more than 15 indications, including wound healing, infections and late effects of radiation, which are largely unresponsive to conventional t...

  4. Pain improvement in rheumatoid arthritis with hyperbaric oxygen: report of three cases.

    Science.gov (United States)

    Slade, John B; Potts, Mary V; Fowler, Alan M; Sit, Michelle T; Schmidt, Thomas W

    2016-01-01

    Rheumatoid arthritis (RA) is a chronic, erosive, symmetrical inflammatory disease that can progress to synovial destruction, severe disability and premature mortality. Immunotherapies, while beneficial, can cause significant adverse events. Three patients with RA treated in our facility with hyperbaric oxygen (HBO₂) for unrelated diagnoses all reported significant but unanticipated improvement in RA-related pain, increased activity and improved sleeping patterns. Two improved while continuing traditional RA medications; the other patient had all RA meds held due to cancer and postoperative wound healing problems. The significant symptomatic improvement in these three patients led us to hypothesize that HBO₂ for patients with RA may result in decreased joint pain, increased activity level, improvement in sleeping patterns and possibly a decreased need for standard rheumatologic medications, effectively reducing or avoiding the effects of immunosuppression. A clinical trial is planned to objectively assess these findings. Copyright© Undersea and Hyperbaric Medical Society.

  5. 高压氧对脑损伤大鼠BDNF表达的影响%Effects of hyperbaric oxygen therapy on the expression level of brain-derived neurotrophic factor after traumatic brain injury in rats

    Institute of Scientific and Technical Information of China (English)

    张禹; 潘树义; 李航; 杨晨; 潘晓雯

    2012-01-01

    Objective To observe the effect of hyperbaric oxygen (HBO) treatment on the expression of brain-derived neu rotrophic factor (BDNF) in cerebral cortex and hippocampus of adult rats with lateral fluid percussion attack. Methods Thir ty-two male Wistar rats were divided into brain-injured group and control group with 16 rats in each group. Lateral brain injury model was established in the brain-injured group by fluid percussion attack machine and those rats were divided into two subgroups to be exposed in HBO and nonpressurized air respectively with eight rats in each subgroup. Heads were cut and brains were taken after five days. The morphological changes in cerebral cortex and hippocampus of the brain specimens were observed with electron microscope and the expressions of BDNF were detected with immunohistochemistry. Results There was no significant difference in the number of BDNF positive cells among each normal control groups (P > 0.05). But there were more BDNF positive cells in HBO exposed injury group than that in nonpressurized air exposed group (P 0.05);脑损伤组中HBO暴露后皮层及海马BDNF免疫阳性细胞数多于常压空气暴露(P < 0.01),脑损伤常压空气暴露组多于正常对照常压空气暴露组(P < 0.01).结论 大鼠脑损伤后可以提高损伤皮层及海马区BDNF的表达,HBO治疗可以进一步提高大鼠脑内BNDF的表达.

  6. The Role of Oxygen Therapies in Carbon Monoxide Poisoning

    Directory of Open Access Journals (Sweden)

    Suleyman Metin

    2011-08-01

    Full Text Available Due to climate and socio-economic issues in Turkey, the incidence of carbon monoxide (CO poisoning is high, especially in winter. Clinical manifestations may vary depending on the type of CO source, concentration and duration of exposure. The symptoms of CO poisoning predominantly manifest in lots of organs and systems with high oxygen utilization, especially the brain and the heart. The primary aim in oxygen therapy is to eliminate CO and to reduce its toxic effects. In this context, normobaric and hyperbaric oxygen therapy are used to achieve these goals. Normobaric oxygen (NBO treatment is an easily accessible and relatively not expensive modality, where hyperbaric oxygen (HBO therapy requires specific equipment, certified staff and is available only in some centers. Additionally, HBO treatment has several additional advantages over NBO treatment. Despite its benefits, it is compulsory to search for some criteria in selecting patients to be treated because of the limited availability and access of hyperbaric facilities. For an effective evaluation and an optimal treatment, advanced education of the healthcare professionals on the use of oxygen delivery modalities in the management of CO poisoning is imperative. In this review, it has been aimed to outline the significance of oxygen treatment modalities and to determine patient selection criteria for HBO treatment in the management of CO poisoning which continues to be an important threat to community health care. [TAF Prev Med Bull 2011; 10(4.000: 487-494

  7. Oxygen therapies and their effects on wound healing.

    Science.gov (United States)

    de Smet, Gijs H J; Kroese, Leonard F; Menon, Anand G; Jeekel, Johannes; van Pelt, Antoon W J; Kleinrensink, Gert-Jan; Lange, Johan F

    2017-08-07

    Oxygen is an important factor for wound healing. Although several different therapies investigated the use of oxygen to aid wound healing, the results of these studies are not unequivocal. This systematic review summarizes the clinical and experimental studies regarding different oxygen therapies for promoting wound healing, and evaluates the outcomes according the methodological details. A systematic literature search was conducted using Embase, Medline, Web of Science, Cochrane, PubMed publisher, and Google Scholar libraries. Clinical and experimental studies investigating oxygen for wound healing were selected. Included articles were categorized according to the kind of therapy, study design, and wound type. The methodological details were extracted and analyzed. Sixty-five articles were identified and divided in three different oxygen therapies: Local oxygen therapy, hyperbaric oxygen therapy, and supplemental inspired oxygen therapy. More than half of the included local oxygen and hyperbaric oxygen studies had one or more significant positive outcomes, 77 and 63%, respectively. Supplemental inspired oxygen therapy during gastrointestinal and vascular surgery was more likely to have a positive result than during other surgical interventions reducing surgical site infections. These many positive outcomes promote the use of oxygen treatment in the stimulation of wound healing. However, the lack of clinical studies and vast methodological diversity made it impossible to perform a proper comparison within and between the different therapies. Further randomized clinical studies are warranted to examine the value of these therapies, especially studies that investigate the more patient-friendly oxygen dressings and topical wound oxygen therapies. Also, to achieve more solid and consistent data, studies should use more standardized methods and subjects. © 2017 by the Wound Healing Society.

  8. Principles and practice of hyperbaric medicine: a medical practitioner's primer, part I.

    Science.gov (United States)

    Perdrizet, George A

    2014-01-01

    The purpose of this monograph is to narrow the knowledge gap between current medical practice and hyperbaric oxygen therapy. Graduate medical education has not kept pace with the expanding science and practice of hyperbaric medicine. The number of hyperbaric chambers in the state of Connecticut has increased by >400% during the past five years. A brief overview of the science and practice of hyperbaric oxygen therapy is presented, with additional resources identified where more in-depth coverage can be found. The reader will find the basics of hyperbaric medical practice reviewed and be able to recognize diagnoses that are appropriate for referral to a hyperbaric medical center. The intended audience is practitioners who have had no formal exposure to hyperbaric medicine or chronic wound care.

  9. 高压氧、鼓室内激素对治疗1周无效突发性聋的疗效对比%Effectiveness of hyperbaric oxygen therapy or intratympanic dexamethasone treatment for sudden sensorineural hearing loss which is no respect for one week’s treatment

    Institute of Scientific and Technical Information of China (English)

    杨立; 余文兴; 黄红星; 黄恒; 唐子轩

    2013-01-01

    目的:了解高压氧或鼓室内激素对入院治疗超过1周无效的中度以上突发性聋患者的治疗价值。方法对56例收入院治疗1周无效的中度以上突发性聋患者临床资料进行回顾性分析。经激素、改善微循环、营养神经等药物治疗治疗1周无效的患者,根据患者意愿分为鼓室内激素注射治疗组和高压氧治疗组,继续使用改善微循环、营养神经等药物,对两组的短期预后进行比较。结果经使用高压氧或鼓室内激素治疗1周,高压氧组平均听力改善12.7±18.0dB,鼓室内激素组听力改善13.6±16.5dB,两组间平均听阈改善差异无统计学差异(t=0.2,P>0.05)。高压氧组治疗有效率为45.2%,鼓室内激素组治疗有效率为48.0%,组间疗效差异无统计学意义(μ=0.54,P>0.05)。发病到开始使用时间7~14天、15~30天、30天以上有效率分别为54.5%、26.7%、37%,组间疗效差异有统计学意义(μ=6.52,P<0.05),所有患者均未出现严重并发症。结论高压氧与鼓室内激素对入院治疗超过1周无效的中度以上突发性聋有治疗意义,两种治疗短期疗效无明显差异,可根据具体情况选择治疗方案。%Objective To investigate and analyze the significance of hyperbaric oxygen therapy or intratympanic dexamethasone treatment for sudden sensorineural hearing loss which is no respect for one week’s treatment .Methods We retrospectived 56 patients with sudden sensorineural hearing loss(SSNHL) who pure tone average (PTA )threshold was more than 40 dB and were admitted to the department of Otorhinolarngology-Head and Neck Surgery ,The Suining Central Hospital from January 2010 to January 2013 ,and they were no respected for one week ’ s treatment .All of the patient were trearted with glucocorticoids ,thrombolytic ,and used hyperbaric oxygen therapy or intratympanic dexamethasone as

  10. Repetitive hyperbaric oxygen treatment increases insulin sensitivity in diabetes patients with acute intracerebral hemorrhage

    Science.gov (United States)

    Xu, Qian; Wei, Yi-ting; Fan, Shuang-bo; Wang, Liang; Zhou, Xiao-ping

    2017-01-01

    Aim The role of hyperbaric oxygen therapy (HBOT) in the treatment of acute ischemic stroke is controversial. This study aims to investigate whether the peripheral insulin sensitivity of type 2 diabetes patients suffering from intracerebral hemorrhage can be increased after HBOT. Methods Fifty-two type 2 diabetes participants were recruited after being diagnosed with intracerebral hemorrhage in our hospital. Insulin sensitivity was measured by the glucose infusion rate during a hyperinsulinemic euglycemic clamp (80 mU m−2 min−1) at baseline and 10 and 30 days after HBOT sessions. Serum insulin, fasting glucose, and hemoglobin A1C were measured in fasting serum at baseline and after HBOT sessions. In addition, early (∼10 days after onset) and late (1 month after onset) outcomes (National Institutes of Health Stroke Scale, NIHSS scores) and efficacy (changes of NIHSS scores) of HBOT were evaluated. Results In response to HBOT, the glucose infusion rate was increased by 37.8%±5.76% at 1 month after onset compared with baseline. Reduced serum insulin, fasting glucose, and hemoglobin A1C were observed after HBOT. Both early and late outcomes of the HBOT group were improved compared with baseline (P<0.001). In the control group, there was significant difference only in the late outcome (P<0.05). In the assessment of efficacy, there were statistically significant differences between the groups when comparing changes in NIHSS scores at 10 days and 1 month after onset (P<0.05). Conclusion Peripheral insulin sensitivity was increased following HBOT in type 2 diabetes patients with intracerebral hemorrhage. The HBOT used in this study may be effective for diabetes patients with acute stroke and is a safe and harmless adjunctive treatment. PMID:28228657

  11. Management of postoperative radiation injury of the urinary bladder by hyperbaric oxygen (HBO)

    Energy Technology Data Exchange (ETDEWEB)

    Peusch-Dreyer, D.; Dreyer, K.H. [Zentrum fuer Tauch- und Ueberdruckmedizin (ZETUeM), Bremen (Germany); Mueller, C.D. [Druckkammerzentrum Magdeburg (Germany); Carl, U. [Klinik fuer Strahlentherapie und Radioonkologie, Universitaet Duesseldorf (Germany)

    1998-11-01

    Aim: In many case reports the success of treatment of late complications of radiotherapy with hyperbaric oxygenation (HBO) has been shown. This synopsis attempts to review HBO in the treatment of chronic radiation injury of the bladder. Patients and methods: Three female patients who had developed urge-incontinence after a Wertheim operation and combined brachy-teletherapy with cobalt-60 and afterloading and did not respond to various drug therapies, were treated with HBO to a maximum of 40 applications. Results: In all patients HBO haltered and inverted the dynamic process underlying chronic bladder changes after irradiation. Rationales for the HBO are the reduction of tissue hypoxia and the induction of neoangiogenesis. Conclusions: There are no prospective trials up to date showing the benefit of HBO to urinary disorders caused by radiation cystitis. The positive results of our retrospective study should encourage clinicians to initiate prospective studies with the use of HBO in the treatment of radiation cystitis. (orig.) [Deutsch] Ziel: Ueber die erfolgreiche Anwendung der hyperbaren Sauerstofftherapie (HBO) zur Behandlung von Strahlenspaetkomplikationen ist in zahlreichen Publikationen berichtet worden. Ziel dieser Arbeit ist es, den Einsatz der HBO bei der Behandlung von Miktionsbeschwerden bei chronisch radiogenen Harnblasenschaeden zu bewerten. Patienten und Methode: Drei Patientinnen, die nach einer kombinierten Brachyteletherapie mit Kobalt 60 und Afterloading nach Wertheim-Operation unter einer medikamentoes nicht zu beeinflussenden Urge-Inkontinenz litten, wurden der HBO mit maximal 40 Behandlungen zugefuehrt. Ergebnisse: Die HBO war bei allen Patientinnen in der Lage, den dynamischen Krankheitsprozess der Strahlenzystitis aufzuhalten und teilweise umzukehren. Grundlage hierfuer ist die Beseitigung der Gewebshypoxie. Dieses wiederum stellt die Voraussetzung fuer eine Neovaskularisation im bestrahlten Gewebe dar. Schlussfolgerung: Prospektive Studien

  12. Clinical pathological study of treatment of chronic hepatitis with hyperbaric oxygenation.

    Science.gov (United States)

    Liu, Wei; Zhao, Wei; Lu, Xiang; Zheng, Xiaogang; Luo, Chan

    2002-08-01

    To detect the feasibility and theoretic basis for treatment with hyperbaric oxygenation (HBO) in chronic hepatitis and to compare the changes in hepatic function, immunity, pathologic morphology, ultrastructure and HBV in hepatic tissues before and after treatment. Sixty cases of chronic hepatitis were randomly selected and divided into two groups: the experiment (n = 30) and control groups (n = 30). Patients in the experimental group were treated with HBO for 6 courses. Patients in the control group were treated for 60 days with the usual drugs used in the clinic. The function and bloodstream graph of liver were examined and liver biopsies were made before and after treatments. Routine paraffin sections were stained with HE and observed under the light microscope. Ultra thin slides from paraformaldehyde and glutaraldehyde fixed liver tissue were stained with lead citrate and observed with the transmission electric microscope. HBsAg and HBcAg in liver of the experimental group were detected with ABC immunohistochemistry method before and after treatment. For the experimental group, ALT, SB, gamma-GT, AKP, IgG, and IgM in blood and the degeneration and necrosis of hepatocytes were remarkably decreased (P 0.05), and the expression of HBsAg and HBcAg in liver was not weakened (P hepatitis was effective and recommendable, but it could not reverse liver fibrosis. However, it might be able to delay or prevent the liver from fibrosis, so it might be more effective at the early and middle stages of chronic hepatitis. HBO could not inhibit the HB virus. So we consider that treatment with HBO should be simultaneous with anti HBV therapy.

  13. Effects of Hyperbaric Oxygen on Inflammatory Response to Wound and Trauma: Possible Mechanism of Action

    Directory of Open Access Journals (Sweden)

    Noori S. Al-Waili

    2006-01-01

    Full Text Available There is growing interest in expanding the clinical applications for HBO2 (hyperbaric oxygen therapy into new medical and surgical fields. The pathophysiology of response towards wounds, infection, trauma, or surgery involves various chemical mediators that include cytokines, prostaglandins (PGs, and nitric oxide (NO. The beneficial role played by HBO2 in wound healing, carbon monoxide poisoning, decompression sickness, and other indications is well documented. However, the exact mechanism of action is still poorly understood. This review addresses the effects of HBO2 on PGs, NO, and cytokines involved in wound pathophysiology and inflammation in particular. The results of this review indicate that HBO2 has important effects on the biology of cytokines and other mediators of inflammation. HBO2 causes cytokine down-regulation and growth factor up-regulation. HBO2 transiently suppresses stimulus-induced proinflammatory cytokine production and affects the liberation of TNFα (tumor necrosis factor alpha and endothelins. VEGF (vascular endothelial growth factor levels are significantly increased with HBO2, whereas the value of PGE2 and COX-2 mRNA are markedly reduced. The effect of HBO2 on NO production is not well established and more studies are required. In conclusion, cytokines, PGs, and NO may play a major role in the mechanism of action of HBO2 and further research could pave the way for new clinical applications for HBO2 to be established. It could be proposed that chronic wounds persist due to an uncontrolled pathological inflammatory response in the wound bed and that HBO2 enhances wound healing by damping pathological inflammation (anti-inflammatory effects; this hypothetical proposal remains to be substantiated with experimental results.

  14. Hyperbaric oxygen treatment for experimental intraocular hypertension in rats: An electroretinogram detection

    Institute of Scientific and Technical Information of China (English)

    Junhui Yi; Zhengrong Peng; Qiuli Liu; Zhongqi Wu

    2007-01-01

    BACKGROUND: Hyperbaric oxygen (HBO) is used for treating glaucoma, and affirmative curative effect has been obtained. HBO can sensitively reflect the obviously heightened b wave of electroretinogram (ERG)of injured tissue.OBJECTIVE: To observe the effect of HBO treatment on retinal function of rats with acute experimental intraocular hypertension with ERG.DESIGN: Randomized controlled experiment.SETTING: Department of Ophthalmology, Third Xiangya Hospital, Central South University; Department of Hyperbaric Oxygen, Xiangya Hospital, Central South University; Department of Anatomy, Xiangya Hospital, Central South University.MATERIALS: Eighteen adult healthy Wistar rats, of either gender, weighing from 150 to 250 g, were provided by the Animal Room of Central South University. Type YLCO. 5/Ⅰ A baby hyperbaric oxygen chamber, type LMS-2A two-channel physiological recorder, type BG-1 retina exposure system, Jiangwan type Ⅰ stereotaxis instrument.METHODS: This experiment was carried out in the Central South University between March and September 2006. Eighteen healthy Wistar rats were made into models of acute experimental intraocular hypertension. Then, they were divided into two groups: model group and HBO treatment group, with 9 in each group. Following 7 days of HBO treatment, the rats in HBO treatment group were placed in Type YLCO. 5/Ⅰ A baby hyperbaric oxygen chamber, which was pressurized with pure oxygen( volume fraction 0.825 ± 0.025).The treatment pressure was 0.2 MPa. The rats in HBO treatment group daily inhaled HBO for 80 minutes within 7 days; Rats in the model group were untouched. The performance of eyes was observed under the status of intraocular hypertension. ERG was recorded before, during and 7 days after modeling,meanwhile, the recovery rate of b wave from ERG was calculated. Recovery rate of b wave from ERG=(amplitude of b wave 7 days after modeling/amplitude of b wave before modeling)× 100%.MAIN OUTCOME MEASURES: ① Performance of eyes

  15. Efeito da oxigenoterapia hiperbárica: relato de caso de paciente com síndrome hepato-pulmonar em lista de espera para transplante hepático Effect of hyperbaric oxygen therapy: case report of patient with hepato-pulmonary syndrome on waiting list for liver transplantation

    Directory of Open Access Journals (Sweden)

    Flávio Kreimer

    2010-06-01

    Full Text Available INTRODUÇÃO: As doenças hepáticas apresentam índices de morbidade e mortalidade elevados e quando em estágio avançado têm o transplante do fígado como forma de tratamento potencialmente curativo e eficaz, embora este não possa ser oferecido a todos os pacientes. Isso faz com que essas doenças sejam consideradas problema de saúde pública em todo o mundo. Os cuidados clínicos para manter o paciente com condições de esperar e suportar o transplante continua um desafio. RELATO DO CASO: Mulher com 65 anos de idade, procedente do Recife, com diagnóstico de cirrose hepática secundária a vírus C apresentava dispnéia importante aos mínimos esforços tendo PaO2 de repouso de 60 mmHg e O2 de 90%, com espirometria normal. Realizou eco-Doppler que evidenciou shunt pulmonar importante. Durante a triagem em lista de transplante (MELD de 16 em agosto de 2006 foi optado pelo início de sessões de oxigenioterapia em câmara hiperbárica a fim de melhorar a sintomatologia respiratória da síndrome hepato-pulmonar. Apresentava melhora substancial da tolerância ao exercício após a terapia hiperbárica, assim como os valores do PaO2 à gasometria. Realizou 10 sessões de oxigenioterapia em câmara hiperbárica. Realizou transplante hepático em outubro de 2007 e vem em acompanhamento ambulatorial com boa evolução e melhora substancial da dispnéia. CONCLUSÃO: Constatou-se melhora da condição hepato-pulmonar após oxigenoterapia hiperbárica. Desta forma, ela surge como mais uma ferramenta para o tratamento das doenças hepáticas, devendo ser realizados outros estudos que avaliem sua utilização clínica.INTRODUCTION: Progressive impairment of liver function in hepatic cirrhosis is a major medical problem with limited therapeutic approaches, and liver transplantation is the only effective therapy. Reports of alternatives for liver function improvement on patients awaiting liver transplantation may include hyperbaric oxygen therapy

  16. 高压氧或鼓室内激素对突发性聋的挽救治疗疗效对比%Effectiveness of hyperbaric oxygen therapy or intratympanic dexamethasone treatment for salvage therapy of sudden sensorineural hearing loss

    Institute of Scientific and Technical Information of China (English)

    杨立; 何刚; 唐子轩; 黄红星

    2014-01-01

    目的:了解高压氧或鼓室内激素对入院治疗超过1周无效的中度以上突发性聋患者的治疗价值。方法对56例收入院治疗1周无效的中度以上突发性聋患者临床资料进行回顾性分析。经激素、改善微循环、营养神经等药物治疗治疗1周无效的患者,根据患者意愿分为鼓室内激素注射治疗组和高压氧治疗组,继续使用改善微循环、营养神经等药物,对两组的短期预后进行比较。结果经使用高压氧或鼓室内激素治疗1周,高压氧组平均听力改善12.7±18.0 dB,鼓室内激素组听力改善13.6±16.5 dB,两组间平均听阈改善差异无统计学差异(t=0.2,p>0.05)。高压氧组治疗有效率为45.2%,鼓室内激素组治疗有效率为48.0%,组间疗效差异无统计学意义(μ=0.54,p>0.05)。发病到开始使用时间7~14天、15~30天、30天以上有效率分别为54.5%、26.7%、37%,组间疗效差异有统计学意义(μ=6.52,p0.05). The efficient in groups of hyperbaric oxygen therapy or intratympanic dexamethasone were 45.2 %,48.0 % separately , which were no significantly different in two groups(μ=0.54,p>0.05). The efficient in SSNHL groups which time from onset to treatment were 7~14days,15~30days,more than one month were 54.5%,26.7%,37%, there was a significant statistic difference among three groups(μ=6.52,p<0.05). Al of the patients were no serious complications.Conclusion:Hyperbaric oxygen therapy or intratympanic dexamethasone treatment is effective for sudden sensorineural hearing loss which is no respect for one week’s treatment. The short-term curative effect are no difference in two treatment.

  17. [Development of physiological monitors based on the Zigbee technology for hyperbaric oxygen chambers].

    Science.gov (United States)

    Zheng, Jin-Nuan; Wu, Bao-Ming; Lin, Jin-Zhao; Wang, Qiang

    2008-05-01

    This paper introduces a monitor that can monitor five physiological parameters (ECG, blood pressure, spo2, respiration and temperature) based on Wireless Sensor Networks. The monitor will be applied to hyperbaric oxygen chambers. After acquisition, the signal will be displayed on the LCD screen of the monitor terminal in the cabin. At the same time, the Zigbee RF module will send the signal to the extravehicular guardianship PC terminals. This monitor equipment can realize synchronous real-time monitoring both inside and outside. What's more? A host can also display monitoring data the three monitor terminals collected. Preliminary clinical tests show that the monitors are safe and the monitoring results are satisfactory.

  18. Effects of hyperbaric oxygen therapy after spinal cord injury: systematic review Efectos de la terapia hiperbárica en el traumatismo raquimedular: revisión sistemática Efeitos da oxigenioterapia hiperbárica no tratamento da lesão medular traumática: revisão sistemática

    Directory of Open Access Journals (Sweden)

    Asdrubal Falavigna

    2009-09-01

    Full Text Available OBJECTIVE: to conduct a systematic review of experimental and clinical studies evaluating the effect of hyperbaric oxygen therapy on the spinal cord injury. METHODS: ninety-three studies were identified in the database Pubmed. Among these, through a set of inclusion/exclusion criteria, 11 articles published between 1963 and 2009 were selected. In the nine experimental studies, different ways to apply the treatment were observed. The measured outcomes were: functional, histological, biochemical and electrophysiological. RESULTS: in most of the studies, the results show recovery of locomotor function, histology and/or biochemical features. Regarding the two studies in clinical samples, the results are controversial. The samples are heterogeneous and the application of hyperbaric oxygen therapy is not the same for all patients in each study. CONCLUSION: considering the results of this review, further studies are necessary to define the role of hyperbaric oxygen therapy in acute spinal cord injury.OBJETIVO: realizar una revisión sistemática de estudios experimentales y clínicos que evaluaban los efectos de la terapia hiperbárica en el traumatismo raquimedular. MÉTODOS: se identificaron noventa y tres estudios en el Pubmed. De estos, por un conjunto de criterios de inclusión y exclusión, se seleccionaron 11 artículos publicados entre 1963 y 2009. Entre los nueve estudios experimentales, se observaron diferentes formas de aplicación del tratamiento. Los resultados mensurados fueron: funcional, histológico, bioquímico y electrofisiológico. RESULTADOS: los resultados muestran, en la mayoría de los estudios, recuperación de la función locomotora, histología y/o características bioquímicas. Tratándose de los estudios clínicos, los resultados son controvertidos. Las muestras son heterogéneas y la aplicación de la terapia hiperbárica no es igual para todos los pacientes en cada estudio. CONCLUSIÓN: considerando los resultados de esta

  19. Temporal changes in tumor oxygenation and perfusion upon normo- and hyperbaric inspiratory hyperoxia

    Energy Technology Data Exchange (ETDEWEB)

    Thews, Oliver [University of Halle, Institute of Physiology, Halle (Saale) (Germany); Vaupel, Peter [University Medical Center Mainz, Department of Radiooncology and Radiotherapy, Tumor Pathophysiology Section, Mainz (Germany)

    2016-03-15

    Inspiratory hyperoxia under hyperbaric conditions has been shown to effectively reduce tumor hypoxia and to improve radiosensitivity. However, applying irradiation (RT) under hyperbaric conditions is technically difficult in the clinical setting since RT after decompression may be effective only if tumor pO{sub 2} remains elevated for a certain period of time. The aim of the present study was to analyze the time course of tumor oxygenation and perfusion during and after hyperbaric hyperoxia. Tumor oxygenation, red blood cell (RBC) flux for perfusion monitoring, and vascular resistance were assessed continuously in experimental rat DS-sarcomas by polarographic catheter electrodes and laser Doppler flowmetry at 1 and 2 atm (bar) of environmental pressure during breathing of pure O{sub 2} or carbogen (95 % O{sub 2} + 5 % CO{sub 2}). During room air breathing, the tumor pO{sub 2} followed very rapidly within a few minutes the change of the ambient pressure during compression or decompression. With O{sub 2} breathing under hyperbaric conditions, the tumor pO{sub 2} increased more than expected based on the rise of the environmental pressure, although the time course was comparably rapid. Breathing carbogen, the tumor pO{sub 2} followed with a slight delay of the pressure change, and within 10 min after decompression the baseline values were reached again. RBC flux increased during carbogen breathing but remained almost constant with pure O{sub 2}, indicating a vasodilation (decrease in vascular resistance) with carbogen but a vasoconstriction (increase in vascular resistance) with O{sub 2} during hyperbaric conditions. Since the tumor pO{sub 2} directly followed the environmental pressure, teletherapy after hyperbaric conditions does not seem to be promising as the pO{sub 2} reaches baseline values again within 5-10 min after decompression. (orig.) [German] Inspiratorische Hyperoxie unter hyperbaren Bedingungen reduziert sehr effektiv die Tumorhypoxie und erhoeht die

  20. [Changes in the oxidant-antioxidant system activity in patients with hepatic failure treated with hyperbaric oxygenation and actoprotectors].

    Science.gov (United States)

    Lakhin, R E; Belozerova, L A; Maksimets, V A; Romanov, D M

    1999-01-01

    Effects of hyperbaric oxygenation, bemitil, and solcoseryl used in preoperative treatment of patients with hepatic failure on the oxidant-antioxidant system are studied. Lipid peroxidation (LPO) was assessed from changes in the levels of malonic dialdehyde and diene conjugate and the antioxidant system from the number of SH-groups. Hyperbaric oxygenation led to activation of LPO processes. Bemitil decreased the intensity of LPO by extending the potentialities of the antioxidant system. Antioxidant properties of solcoseryl were not realized through the thiol buffer of the antioxidant system. Only a course of treatment with this drug brings about a stable effect.

  1. Is there a role for hyperbaric oxygen as primary treatment for grade IV radiation-induced haemorrhagic cystitis? a prospective pilot-feasibility study and review of literature

    Energy Technology Data Exchange (ETDEWEB)

    Dellis, Athanasios [Surgical Department, University of Athens, Aretaieion Hospital (Greece); Deliveliotis, Charalambos [Urologic Department, University of Athens, Sismanoglio General Hospital (Greece); Kalentzos, Vasileios; Vavasis, Pavlos; Skolarikos, Andreas [Diving and Hyperbaric Oxygen Department, Naval and Veterans Hospital, Athens (Greece)

    2014-05-15

    Purpose: To examine the safety and efficacy of hyperbaric oxygen as the primary treatment for Grade IV radiation-induced haemorrhagic cystitis. Materials and Methods: Hyperbaric oxygen was prospectively applied as a primary treatment option in 11 patients with Grade IV radiation cystitis. Primary endpoint was the incidence of complete and partial response to treatment. Secondary endpoints included the duration of response, the correlation of treatment success-rate to the interval between the onset of haematuria and initiation of therapy, blood transfusion need and total radiation dose, the number of sessions to success, the avoidance of surgery and the overall survival. Results: All patients completed therapy without complications for a mean follow-up of 17.82 months (range 3 to 34). Mean number of sessions needed was 32.8 (range 27 to 44). Complete and partial response rate was 81.8% and 18.2%, respectively. However, in three patients the first treatment session was not either sufficient or durable giving a 72.7% rate of durable effect. Interestingly, all 9 patients with complete response received therapy within 6 months of the haematuria onset compared to the two patients with partial response who received therapy at 8 and 10 months from the haematuria onset, respectively (p = 0.018). The need for blood transfusion (p = 0.491) and the total radiation dose (p = 0.259) were not correlated to success-rate. One patient needed cystectomy, while all patients were alive at the end of follow-up. Conclusions: Early primary use of hyperbaric oxygen to treat radiation-induced grade IV cystitis is an effective and safe treatment option. (author)

  2. Effects of normobaric versus hyperbaric oxygen on cell injury induced by oxygen and glucose deprivation in acute brain slices.

    Science.gov (United States)

    Chazalviel, Laurent; Blatteau, Jean-Eric; Vallée, Nicolas; Risso, Jean-Jacques; Besnard, Stéphane; Abraini, Jacques H

    2016-01-01

    Normobaric oxygen (NBO) and hyperbaric oxygen (HBO) are emerging as a possible co-treatment of acute ischemic stroke. Both have been shown to reduce infarct volume, to improve neurologic outcome, to promote endogenous tissue plasminogen activator-induced thrombolysis and cerebral blood flow, and to improve tissue oxygenation through oxygen diffusion in the ischemic areas, thereby questioning the interest of HBO compared to NBO. In the present study, in order to investigate and compare the oxygen diffusion effects of NBO and HBO on acute ischemic stroke independently of their effects at the vascular level, we used acute brain slices exposed to oxygen and glucose deprivation, an ex vivo model of brain ischemia that allows investigating the acute effects of NBO (partial pressure of oxygen (pO2) = 1 atmospheres absolute (ATA) = 0.1 MPa) and HBO (pO2 = 2.5 ATA = 0.25 MPa) through tissue oxygenation on ischemia-induced cell injury as measured by the release of lactate dehydrogenase. We found that HBO, but not NBO, reduced oxygen and glucose deprivation-induced cell injury, indicating that passive tissue oxygenation (i.e. without vascular support) of the brain parenchyma requires oxygen partial pressure higher than 1 ATA.

  3. Mild Hyperbaric Oxygen Improves Decreased Oxidative Capacity of Spinal Motoneurons Innervating the Soleus Muscle of Rats with Type 2 Diabetes.

    Science.gov (United States)

    Takemura, Ai; Ishihara, Akihiko

    2016-09-01

    Rats with type 2 diabetes exhibit decreased oxidative capacity, such as reduced oxidative enzyme activity, low-intensity staining for oxidative enzymes in fibers, and no high-oxidative type IIA fibers, in the skeletal muscle, especially in the soleus muscle. In contrast, there are no data available concerning the oxidative capacity of spinal motoneurons innervating skeletal muscle of rats with type 2 diabetes. This study examined the oxidative capacity of motoneurons innervating the soleus muscle of non-obese rats with type 2 diabetes. In addition, this study examined the effects of mild hyperbaric oxygen at 1.25 atmospheres absolute with 36 % oxygen for 10 weeks on the oxidative capacity of motoneurons innervating the soleus muscle because mild hyperbaric oxygen improves the decreased oxidative capacity of the soleus muscle in non-obese rats with type 2 diabetes. Spinal motoneurons innervating the soleus muscle were identified using nuclear yellow, a retrograde fluorescent neuronal tracer. Thereafter, the cell body sizes and succinate dehydrogenase activity of identified motoneurons were analyzed. Decreased succinate dehydrogenase activity of small-sized alpha motoneurons innervating the soleus muscle was observed in rats with type 2 diabetes. The decreased succinate dehydrogenase activity of these motoneurons was improved by mild hyperbaric oxygen. Therefore, we concluded that rats with type 2 diabetes have decreased oxidative capacity in motoneurons innervating the soleus muscle and this decreased oxidative capacity is improved by mild hyperbaric oxygen.

  4. Hyperbaric oxygen therapy sensitizes chemotherapy in human glioma-bearing nude mice%HBO联合尼莫司汀治疗脑胶质瘤裸小鼠模型的研究

    Institute of Scientific and Technical Information of China (English)

    刘兵; 戴纯刚; 芮琴; 马加威; 王爱东; 陆朝晖; 黄强

    2015-01-01

    目的 探讨高压氧(hyperbaric oxygen,HBO)联合化疗药物治疗脑胶质瘤裸小鼠模型中的增敏效应.方法 将鼠间传代胶质瘤组织块接种于裸小鼠皮下后第3天将其随机分为对照组(n=10)、HBO组(n=5)、尼莫司汀(nimustine,ACNU)组(n=5)、ACNU+ HBO组(n=5).HBO治疗:将荷瘤鼠置于无特殊病原体的HBO-IVC装置内,每天1次1小时HBO治疗.ACNU治疗:给予30 mg/kg腹腔注射,每周1次,共3次.实验结束时取移植瘤组织,qPCR法检测肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、基质金属蛋白酶9(matrix metalloprotein 9,MMP9)、低氧诱导因子-1α(hypoxia inducible factor-1 α,HIF-1α)和内皮糖蛋白(endoglin,CD105)的mRNA转录情况.结果 对照组(n=10)移植瘤质量为(5.28±1.78)g,HBO组(n=5)为(3.47±1.57)g,ACNU组(n=5)为(2.20±0.12)g,两组与对照组比较差异均有统计学意义(P =0.008,P=0.000).ACNU+ HBO组(n=5)为(1.73±0.63)g,与对照组及ACNU组比较差异均有统计学意义(均P=0.004).HBO+ ACNU组的肿瘤组织坏死减轻,宿主源性免疫炎性细胞减少.TNF-α、MMP9、HIF-1 α和CD105的mRNA转录水平在ACNU和HBO+ ACNU组下降.结论 ACNU联合HBO治疗荷胶质瘤裸小鼠皮下移植瘤有效,HBO联合ACNU疗效更明显,其机制可能与抑制肿瘤相关炎性细胞浸润、TNF-α、MMP9、HIF-1 α和CD105的表达有关.

  5. Evaluation of the therapeutic effect of hyperbaric oxygenation and erythropoietin in the treatment of chronic heart failure using myocardial perfusion scintigraphy G-SPECT

    Directory of Open Access Journals (Sweden)

    Baškot Branislav

    2009-01-01

    Full Text Available Background. The most important predictors of longterm survival in patients with cardiac ischemic disease are left ventricular ejection fraction, left ventricular volumes, infarction size, presence and extent of residual myocardial ischemia. One of the most important recent developments in single photon emission computed tomography (SPECT myocardial perfusion imaging is the ability to acquire these studies in conjunction with electrocardiogram (ECG gating (G-SPECT. The ability to asses radionuclide myocardial perfusion and function with ECG G-SPECT imaging has revolutionized this field of nuclear cardiology. Study with G-SPECT development algorithms permits to quantify measures of left ventricular (LV volume, ejection fraction (LVEF and even regional myocardial wall motion and thickening. The American Society of Nuclear Cardiology (ASNC in its position paper from March 1999 recommends the routine incorporation of G-SPECT during cardiac perfusion scintigraphy. Case report. We presented a 70-year-old male with ischemic heart disease (dilatative, cardiomyopathy and absolute arrhythmia. He was few times hospitally treated by medicamentous therapy with no evidence of improvement. After hospital treatment, we included hyperbaric oxygenation (HBO and erythropoietin injections. Hyperbaric oxygenation was carried out in a monoplace hyperbaric chamber, BLK S-303, by a graduated protocol for patients with severe heart insufficiency, totally 15 treatments. Recombinant erythropoietin beta (RecormonR F. Hoffmann-La Roche was applied deeply subcutaneously, every second day from 2 000 IU to totally 16 000 IU. Before the therapy G-SPECT study was performed with 99m technetium-MIBI, and we obtained the functional parameters and perfusion of the left ventricle to follow-up the therapy effects. The study was performed by an ADAC-VERTEX PLUS-EPIC two-head gamma camera with dedicated quantitatively algorithm Auto-QUANT. The results of LVEF were 15%, with severity

  6. Clinical characteristics of the patients with obstructive sleep apnea hypopnea syndrome treated by hyperbaric oxygen therapies%高压氧治疗阻塞型睡眠呼吸暂停低通气综合征疗效分析

    Institute of Scientific and Technical Information of China (English)

    吕苏明; 张天友; 丁利; 林月友

    2016-01-01

    目的:通过分析高压氧治疗阻塞型睡眠呼吸暂停低通气综合征(OSAHS )前后多导呼吸睡眠监测(PSG )数据,探讨其治疗疗效。方法:对2012年12月至2015年4月40例OSAHS患者治疗,对比观察治疗前后PSG数据,包括呼吸暂停低通气指数、最长呼吸暂停时间、睡眠期最低血氧饱和度、睡眠期平均血氧饱和度、睡眠结构等,并结合患者年龄,BMI等进行分析。结果:治疗前患者年龄、BMI、REM睡眠与AHI值有极显著性差异( P<0.01)。高压氧治疗前后快速眼动期睡眠2组间差异有显著性改善( P<0.05)。治疗前后AHI指数,呼吸暂停指数,最长呼吸暂停时间,低通气指数,最低血氧饱和度,平均血氧饱和度等变化有改善( P<0.01)。结论:高压氧治疗能改善阻塞型睡眠呼吸暂停综合征患者的呼吸调节功能和睡眠结构,减轻夜间缺氧程度和相应症状。%Objective] To explore the clinical features and diagnosis of the patients with obstructive sleep apnea hypopnea syn-drome (OSAHS) treated by hyperbaric oxygen therapies .[Method] Forty patients with OSAHS were selected ,every patient was monitored with polysomnography (PSG) at night ,the data were analyzed including NREM ,REM ,AHI(First appear ,No Abbreviations!!) ,the longest apnea time ,SaO2 ,etc .Meanwhile ,the parameters were compared before and after the hyper-baric oxygen treatment ,also the relationships between groups in age ,BMI ,sleep architecture and AHI before treatment were analyzed .[Result] There was statistically significant differences between groups in AHI index and age ,BMI ,REM sleep ( P<0.01 ) .The difference in REMs before and after treatment was significant ( P<0.05 ) .Also ,the difference in PSG index be-fore and after the treatment was statistically significant ( P<0.01) .[Conclusion] Hyperbaric oxygen treatment can effectively improve respiratory regulatory function ,sleep quality and a

  7. Conservative surgical management of necrotic tissues following meningococcal sepsis: case report of a child treated with hyperbaric oxygen.

    Science.gov (United States)

    Takac, Ines; Kvolik, Slavica; Divkovic, Dalibor; Kalajdzic-Candrlic, Jasenka; Puseljic, Silvija; Izakovic, Senka

    2010-01-01

    This article presents the case of a 5-month-old infant, who survived a fulminant meningococcal sepsis with purpura fulminans, septic shock and severe DIC with gastrointestinal bleeding. Amputation and reconstructive surgery were considered to treat the multiple skin and limb necroses at high risk of superinfection, but the surgical intervention was delayed due to the extremely doubtful outcome. On Day 10 after the onset of the disease, a hemodynamic improvement was achieved. The baby overcame early critical period, but was still in poor general condition. The hyperbaric oxygenation (HBO2) as adjuvant therapy was started in the monoplace chamber using the following protocol: from first through fifth day 45 minutes twice a day on 1.5 atmosphere absolute (ATA); after a two-day break, once a day on 1.8 ATA for 60 minutes. During 52 HBO2 treatments multiple areas of necrotic skin and subcutaneous tissue, together with fingertips and toes, detached spontaneously. All wounds healed without reinfections. An increased oxygen concentration during HBO2 therapy promoted spontaneous wound healing. Bacterial superinfection was not observed in numerous low-perfused lesions. Since repeated anesthesia and surgical interventions were not needed, a final invalidity was minimized. To the best of our knowledge, this is the first report on the successful conservative surgical treatment of this mutilating disease without aggressive reconstructive surgery in an infant with the help of HBO2.

  8. 不同时间窗及疗程的高压氧治疗对急性脑梗死的影响%The effect of different time-window and courses of hyperbaric oxygenation therapy in patients with acute ischemic stroke

    Institute of Scientific and Technical Information of China (English)

    王晓红; 黄礼群; 龚琴; 李宁

    2011-01-01

    Objective To evaluate the efficacy and safety of different time-windows and courses of hyperbaric oxygenation in patients with acute ischemic stroke. Methods 140 patients were divided into 7 groups according to the starting time-windows and courses of hyperbaric oxygenation. Hyperbaric oxygenation were administered at less than 12 h,12 h to 7 d,more than 7 days after infarction with courses of 20 or 40 d. National institues of health stroke scale(NIHSS) , activity of daily life(ADL) and electroencephalogram (EEG) were examined pre- and post-treatment. Results With the same course of hyperbaric oxygenation, the earlier hyperbaric oxygenation,the better the NIHSS, ADL and EEG evaluation got (P<0. 05) ;With the same time-window of hyperbaric oxygenation, the longer the course of hyperbaric oxygenation, the better the NIHSS, ADL and EEG evaluation got (P<0. 05). Conclusion The efficacy and safety of hyperbaric oxygenation are reliable in acute ischemic stroke,and the best therapeutic time-window is less than 12 h after stroke attacked. But there still exist significant improvement in 7 d post-stroke,and the longer the course took,the better the result improved.%目的 探讨不同时间窗及疗程的高压氧治疗对急性脑梗死疗效的影响.方法 140例急性脑梗死患者按从发病到高压氧治疗的时间窗及疗程分为7组,对各组患者在高压氧治疗前、后分别进行神经功能缺损程度、日常生活活动能力(ADL)评分及脑电图检查,并进行各组之间的比较.结果 在进行同样疗程的高压氧治疗中,越早进行高压氧治疗,患者美国国立卫生研究院卒中量表(NIHSS)、ADL评分及脑电图结果越好,差异有统计学意义(P<0.05);相同时间开始高压氧治疗,疗程越长,患者的NIHSS、ADL评分及脑电图结果越好,差异有统计学意义(P<0.05).结论 高压氧治疗急性脑梗死疗效可靠,在脑梗死后12 h以内开始高压氧治疗效果最好,7 d后开始行高压氧治疗

  9. Simultaneous Monitoring of Vascular Oxygenation and Tissue Oxygen Tension of Breast Tumors Under Hyperbaric Oxygen Exposure

    Science.gov (United States)

    2008-04-01

    biological tissue, and allow for detection of specific light-absorbing chromophores in human in vivo, such as oxygenated and deoxygenated hemoglobin...spectra from tumor tissue. Briefly, continuous wave (CW) light from a 20 W tungsten-halogen light source (HL-2000HP, ocean optics, FL) is coupled...spectrometer (USB2000, Ocean optics, FL). The broadband light diffuse spectrometer provides reflectance spectra from 400 to 900 nm. According to

  10. Efeito do alopurinol e terapia com oxigênio hiperbárico em modelo de reimplante de membro após isquemia quente em ratos Effect of allopurinol and hyperbaric oxygen therapy in a limb replantation model after warm ischemia in rats

    Directory of Open Access Journals (Sweden)

    Marcelo Sacramento Cunha

    2005-04-01

    Full Text Available OBJETIVO: A isquemia prolongada leva a alterações na microcirculação tecidual e liberação de radicais livres do oxigênio conhecidas como fenômeno de não reperfusão. Foi testado um modelo experimental de reimplante de membro após isquemia quente e os efeitos do fármaco alopurinol e da terapia com oxigênio hiperbárico. MÉTODO: Foram realizadas amputações com preservação dos vasos e nervos dos membros posteriores direitos em 95 ratos. Os grupos modelos M1, M2, M3, M4 e M5 foram submetidos à isquemia quente de 0, 2, 4, 6 e 8 horas. As taxas de viabilidade dos membros isquêmicos após sete dias de avaliação foram 100%, 80%, 63,6%, 50% e 20%. Os grupos experimentais E1 e E2 foram tratados, respectivamente, com alopurinol e terapia com oxigênio hiperbárico após isquemia de 6 horas. As taxas de viabilidade foram 70% e 30%. Os resultados foram analisados estatisticamente pelo teste do Qui-quadrado. RESULTADOS: Os grupos M1, M2, M3, M4 e M5 foram estatisticamente diferentes entre si exceto os grupos M3 e M4. E1 resultou em uma viabilidade de membros maior que M4 e E2 resultou em uma viabilidade de membros menor que M4(resultados estatisticamente significantes. CONCLUSÕES: Os resultados sugerem que a administração do alopurinol após isquemia do membro por 6 horas aumenta a taxa de viabilidade dos membros isquêmicos, e a terapia com oxigênio hiperbárico diminuiu a viabilidade dos membros isquêmicos.BACKGROUND: Prolonged ischemia leads to alterations in tissue microcirculation and oxygen free radicals production. This event is called no reflow phenomenon and its management is a challenge to the surgeon dealing with replantation. It was tested a replantation model after warm ischemia in rats and the effectiveness of allopurinol and hyperbaric oxigen therapy. METHODS: Amputation with preservation of vessels and nerves of the right hind limb was proceeded in 95 rats. The groups M1, M2, M3, M4 and M5 were submitted to 0, 2, 4, 6

  11. Guiding principles in choosing a therapeutic table for DCI hyperbaric therapy.

    Science.gov (United States)

    Antonelli, C; Franchi, F; Della Marta, M E; Carinci, A; Sbrana, G; Tanasi, P; De Fina, L; Brauzzi, M

    2009-03-01

    Hyperbaric therapy is the basis of treatment for pervasive development disorders. For this reason, the choice of the right therapeutic table for each case is critical. Above all, the delay in recompression time with respect to the first symptoms and to the severity of the case must be considered. In our experience, the use of low-pressure oxygen tables resolves almost all cases if recompression takes place within a short time. When recompression is possible almost immediately, the mechanical effect of reduction on bubble volume due to pressure is of remarkable importance. In these cases, high-pressure tables can be considered. These tables can also be used in severe spinal-cord decompression sickness. The preferred breathing mixture is still disputed. Heliox seems to be favored because it causes fewer problems during the recompression of divers, and above all, because nitrox can cause narcosis and contributes nitrogen. Saturation treatment should be avoided or at least used only in special cases. In cases of arterial gas embolism cerebral injury, it is recommended to start with an initial 6 ATA recompression only if the time between symptom onset and the beginning of recompression is less than a few hours.

  12. Influence of hyperbaric oxygen on the differentiation of hypoxic/ischemic brain-derived neural stem cells

    Institute of Scientific and Technical Information of China (English)

    Zhengrong Peng; Sue Wang; Pingtian Xiao

    2009-01-01

    BACKGROUND: It has been previously shown that hyperbaric oxygen may promote proliferation of neural stem cells and reduce death of endogenous neural stem cells (NSCs).OBJECTIVE: To explore the effects of hyperbaric oxygen on the differentiation of hypoxic/ischemic brain-derived NSCs into neuron-like cells and compare with high-concentration oxygen and high pressure.DESIGN, TIME AND SETTING: An in vitro contrast study, performed at Laboratory of Neurology,Central South University between January and May 2006.MATERIALS: A hyperbaric oxygen chamber (YLC 0.5/1A) was provided by Wuhan Shipping Design Research Institute; mouse anti-rat microtubute-associated protein 2 monoclonal antibody by Jingmei Company, Beijing; mouse anti-rat glial fibrillary acidic protein monoclonal antibody by Neo Markers,USA; mouse anti-rat galactocerebroside monoclonal antibody by Santa Cruz Biotechnology Inc.,USA; and goat anti-mouse fluorescein isothiocyanate-labeled secondary antibody by Wuhan Boster Bioengineering Co., Ltd., China.METHODS: Brain-derived NSCs isolated from brain tissues of neonatal Sprague Dawiey rats werecloned and passaged, and assigned into five groups: normal control, model, high-concentration oxygen, high pressure, and hyperbaric oxygen groups. Cells in the four groups, excluding the normal control group, were incubated in serum-containing DMEM/F12 culture medium. Hypoxic/ischemic models of NSCs were established in an incubator comprising 93% N2, 5% CO2, and 2% O2.Thereafter, cells were continuously cultured as follows: compressed air (0.2 MPa, 1 hour, once a day)in the high pressure group, compressed air+a minimum of 80% O2 in the hyperbaric oxygen group,and a minimum of 80% O2 in the high-concentration oxygen group. Cells in the normal control and model groups were cultured as normal.MAIN OUTCOME MEASURES: At day 7 after culture, glial fibrillary acidic protein,microtubule-associated protein 2, and galactocerebroside immunofluorescence staining were examined to

  13. [Treatment of mucormycosis with adjunctive hyperbaric oxygen: five cases treated at the same institution and review of the literature].

    Science.gov (United States)

    García-Covarrubias, Lisardo; Barratt, Diana M; Bartlett, Robert; Van Meter, Keith

    2004-01-01

    Mucormycosis is an invasive fungal infection that affects decompensated diabetics, immunosupressed patients and occasionally healthy individuals. Despite advances in anti-fungal therapy and surgical techniques, the morbidity and mortality remain high. Adjuvant hyperbaric oxygen therapy (HBO) has been proposed based on pathophysiology and several favorable clinical reports. A chart review of mucormycosis patients referred to the HBO service was performed. Also an electronic search in Medline of relevant literature was undertaken. Five mucormycosis patients referred for HBO had complete charts available. Four had craniofacial involvement and one had left upper extremity involvement. The predisposing diseases were leukemia (n = 3), diabetes mellitus plus sarcoidosis (n = 1), and trauma (n = 1). All patients were managed with amphotericin B, surgical debridement and HBO. Survival was 60% (3/5) three months after the diagnosis was established. The literature was scarce but favors HBO. Considering the pathophysiology of mucormycosis adjuvant HBO therapy seems reasonable. However, the clinical experience is still too limited to make HBO part of the standard of care. Prospective, randomized, controlled trials will help to define the role of HBO in this devastating infection.

  14. Preconditioning with hyperbaric oxygen and hyperoxia induces tolerance against spinal cord ischemia in rabbits.

    Science.gov (United States)

    Dong, Hailong; Xiong, Lize; Zhu, Zhenghua; Chen, Shaoyang; Hou, Lichao; Sakabe, Takefumi

    2002-04-01

    The aim of this study was to determine if the ischemic tolerance could be induced in the spinal cord by pretreatment with hyperbaric oxygen (HBO) and what components of HBO (hyperoxia, hyperbaricity, and combination of these two) were critical in the induction of tolerance against ischemic injury. In experiment 1, 21 rabbits were randomly assigned to one of three groups (n = 7 each): animals in the control group received no HBO before spinal cord ischemia; animals in the HBO-1 and HBO-2 groups received HBO (2.5 atmosphere absolute [ATA], 100% O2) pretreatment 1 h/day for 3 and 5 days before ischemia, respectively. In experiment 2, 48 rabbits were randomly assigned to one of four groups (n = 12 each): the control group received no HBO (21% O2, 1 ATA, 1 h/day, 5 days) before spinal cord ischemia; the HB group received 1-h treatment in 21% O2 at 2.5 ATA each day for 5 days; the HO group received 1-h treatment in 100% oxygen at 1 ATA each day for 5 days; and the HBO group received HBO (2.5 ATA, 100% O2) treatment 1 h/day for 5 days. Twenty-four hours after the last treatment, spinal cord ischemia was induced by an infrarenal aorta clamping for 20 min. Forty-eight hours after reperfusion, hind-limb motor function and histopathology of the spinal cord were examined in a blinded fashion. In experiment 1, the neurologic outcome in the HBO-2 group was better than that of the control group (P = 0.004). The number of normal neurons in the anterior spinal cord in the HBO-2 group was more than that of the control group (P = 0.021). In experiment 2, the neurologic and histopathologic outcomes in the HBO group were better than that of the control group (P Serial exposure to high oxygen tension induced ischemic tolerance in spinal cord of rabbits. Simple hyperbaricity (2.5 ATA, 21% O2) did not induce ischemic tolerance.

  15. HYPERBARIC OXYGEN TREATMENT IN SPINAL CORD INJURY——EXPERIMENTAL AND CLINICAL STUDIES

    Institute of Scientific and Technical Information of China (English)

    汤华丰; 过邦辅; 冯德炎; 钱不凡; 叶衍庆; 徐鹏

    1993-01-01

    Fifty male New Zealand rabbits were used. The ventral impact method ofproducing reversible cord injury was carried out with a force of 161 g-cm. 28 animalswere assigned to the hyperbaric oxygen (HBO)group, and 22 to the control group.Cortical evoked potential (CEP) was adopted as the method of observation at 6 hours, 1,2, 3, and 8 days after injury and pathologic. Examination was done. Measuremen of CEPand the recovery patterns of CEP were compared between the two groups. The HBOgroup showed a CEP recovery rate of 33.51% while in the control group the rate was2.14% with statistical significance (P<0.01). Electron microscopic examination showedthat in the HBO group, normal morphology of nervous fibers could be seen with intactcytoplasmic and nuclear membrane. The outlie of the mitochondria was clear. No obviousswelling of the axon and the sheath could be detected. Clinically there were 35 cases ofacute spinal cord injury undergoing hyperbaric oxygen treatment and among these 19 weredue to fracture-dislocation of the cervical spine and 16 due to fracture-dislocation of thethoraco-lumbar spine. Patients were kept under 2.5 ATA with pure oxygen mask, for 90minutes with interval of 3-4 hours and 3 treatments constituted one course. Out of the 35cases admitted for HBO treatment, 26 incomplete paraplegia patients showed complete orpartial recovery while there was no improvement in neural function in nine cases of com-plete paraplegia according to Frankel classification, there were 4 cases with improvementfrom A to D, 4 cases from B to D, 4 cases from B to E and 2 cases from C to D, im-plying marked improvement in neural function.

  16. [Enhancing the efficiency of sanatorium and resort rehabilitation of the liquidators of the Chernobyl accident by hyperbaric oxygenation].

    Science.gov (United States)

    Ovod, V O; Shymonko, I T

    2003-01-01

    Results of our studies permit reaching the conclusion that oral intake of the mineral water Naftusya as the leading factor with an additional prescription of the course of the hyperbaric oxygenation procedures promote enhancement of functional reserves, stabilize free-radical processes and bodily system of antioxidant defence, favour stabilization of cell membranes, initiate decorporative action, diminish depression of immunity and supply oxygen to those enzymic systems whose activity has been adversely affected by hypoxia.

  17. Reinforcement of the bactericidal effect of ciprofloxacin on Pseudomonas aeruginosa biofilm by hyperbaric oxygen treatment

    DEFF Research Database (Denmark)

    Kolpen, Mette; Mousavi, Nabi; Sams, Thomas

    2016-01-01

    mechanisms affecting antibiotic effectiveness on biofilms remain unclear, accumulating evidence suggests that the efficacy of several bactericidal antibiotics such as ciprofloxacin is enhanced by stimulation of the aerobic respiration of pathogens, and that lack of O2 increases their tolerance. Reoxygenation...... of O2-depleted biofilms may thus improve susceptibility to ciprofloxacin possibly by restoring aerobic respiration. We tested such a strategy using reoxygenation of O2-depleted P. aeruginosa strain PAO1 agarose-embedded biofilms by hyperbaric oxygen treatment (HBOT) (100% O2, 2.8bar), enhancing...... the diffusive supply for aerobic respiration during ciprofloxacin treatment. This proof-of-principle study demonstrates that biofilm reoxygenation by HBOT can significantly enhance the bactericidal activity of ciprofloxacin on P. aeruginosa. Combining ciprofloxacin treatment with HBOT thus clearly has potential...

  18. Influence of nitric oxide synthase inhibitor on gerbil behavior after hyperbaric oxygen-induced convulsion

    Institute of Scientific and Technical Information of China (English)

    Jianguang Zhou; Changyun Liu; Yiqun Fang; Yingqi Zhou; Erli Xu; Jingchang Liu

    2008-01-01

    BACKGROUND: Studies have reported that nitric oxide synthase (NOS) inhibitor can prolong the latency of hyperbaric oxygen-induced convulsion (HBOC). However, there are very few reports addressing the influence of NOS inhibitor on mental behavior.OBJECTIVE: To investigate behavioral changes after HBOC in gerbils, as well as the influence of NOS inhibitor.DESIGN, TIME AND SETTING: Randomized experiments were performed in the Laboratory of Hyperbaric Pressure and Diving Physiology, Naval Medical Research Institute of Chinese PLA (Shanghai,China) from March 2005 to June 2007.MATERIALS: Forty male gerbils were randomly divided into five groups: HBOC, saline control, NOS inhibitor, pressure control, and normal control. Each group contained eight animals.METHODS: In the HBOC group, once depression induction ended, animals were removed from the chamber five minutes after the first appearance of generalized convulsion induced by 0.5 MPa hyperbaric oxygen. Ten minutes before entering the chamber, saline control and NOS inhibitor animals were intraperitoneally injected with 1 mL saline and 20 mg/kg NG-nitro-L-arginine, respectively. The pressure control group was only exposed to 0.5 MPa. The remaining procedures in these three groups were identical to the HBOC group. The normal control group received no intervention.MAIN OUTCOME MEASURES: Open field test scores in gerbils prior to HBOC, as well as immediately,24 hours, and 72 hours after decompression ended.RESULTS: HBOC was not detected in either the normal control or the pressure control group, and there were no significant differences in opcn field test scores prior to and after HBOC (P > 0.05). HBOC occurred in the HBOC, saline control, and NOS inhibitor groups, with significant differences in open field test scores after decompression ended compared to normal control and pressure control groups (P < 0.05-0.01).Compared to the HBOC and saline control groups, the NOS inhibitor group exhibited a significantly lower score in

  19. Analysis of therapeutic effect of hyperbaric oxygen therapy on neuropsychological disorders in senile patients with type 2 diabetes mellitus combined with cerebral infarction%高压氧治疗老年2型糖尿病并存脑梗死患者神经心理障碍的疗效分析

    Institute of Scientific and Technical Information of China (English)

    陈灶萍; 刘军; 查英; 盛励; 史莉华

    2008-01-01

    Objective To explore the therapeutic effect of hyperbaric oxygen therapy (HBO) in the treatment of neuropsychological disorders in senile patients with type 2 diabetes mellitus combined with cerebral infarction. Methods A total of 70 senile patients with type 2 diabetes mellitus combined with cerebral infarction were randomly divided into two groups: treatment group receiving HBO plus routine medicine treatment and control group receiving routing medicine treatment only. A suit of senile neuropsychological tests was administered pre and post treatment by an experienced psychometrician who was blinded to treatment group assignments. Results Neuropsychological disorders were improved partly in control group while the efficacy in treatment group was markedly improved(P<0.01). Spearman rank correlation analysis revealed that the improvement degree of neuropsychological disorders was positively correlated with hyperbaric oxygen therapy (HBO) (r= 0.502,P<0.05), the time of test before therapy (r=0.260, P<0.05) and the time of test after therapy (r=0.386, P<0.05), and was negatively correlated with hyperlipoidemia (r=-0.261, P< 0.05), glycosylated hemoglobin(GHbAlc) (r=-0.321,P<0.05) and body mass index(BMI) (r= 0.360,P<0.05). Multiple stepwise regression analysis showed that HBO and hyperlipoidemia were the independent predictors for the improvement degree of neuropsychological disorders. Conclusions HBO is an efficacious way to treat neuropsychological disorders in senile patients with type 2 diabetes mellitus combined with cerebral infarction.%目的 探讨高压氧治疗老年2型糖尿病并存脑梗死患者神经心理障碍的有效性. 方法 将70例入选患者随机分为治疗组和对照组,治疗组在常规药物治疗基础上联合10次高压氧治疗.选用老年成套心理测验,对所有患者治疗前后进行测试. 结果 对照组患者神经心理障碍得到部分改善,治疗组患者改善程度明显提高(P<0.01).Spearman相关分析显示

  20. Umbilical cord-derived mesenchymal stem cell transplantation combined with hyperbaric oxygen treatment for repair of traumatic brain injury

    Institute of Scientific and Technical Information of China (English)

    Hai-xiao Zhou; Zhi-gang Liu; Xiao-jiao Liu; Qian-xue Chen

    2016-01-01

    Transplantation of umbilical cord-derived mesenchymal stem cells (UC-MSCs) for repair of traumatic brain injury has been used in the clinic. Hyperbaric oxygen (HBO) treatment has long been widely used as an adjunctive therapy for treating traumatic brain injury. UC-MSC transplantation combined with HBO treatment is expected to yield better therapeutic effects on traumatic brain injury. In this study, we established rat models of severe traumatic brain injury by pressurized lfuid (2.5–3.0 atm impact force). The injured rats were then administered UC-MSC transplantationvia the tail vein in combination with HBO treatment. Compared with monotherapy, aquaporin 4 expression decreased in the injured rat brain, but growth-associated protein-43 expression, calaxon-like structures, and CM-Dil-positive cell number increased. Following combination therapy, however, rat cognitive and neurological function signiifcantly improved. UC-MSC transplantation combined with HBO therapyfor repair of traumatic brain injury shows better therapeutic effects than monotherapy and signiifcantly promotes recovery of neurological functions.

  1. The symptoms of depression and anxiety in patients with diabetic foot treated with hyperbaric oxygen - preliminary results

    Directory of Open Access Journals (Sweden)

    Koźmin-Burzyńska Agnieszka

    2016-03-01

    Full Text Available The aim of the study was to assess the level of anxiety and depressiveness in patients who had qualified for hyperbaric oxygen therapy (HBOT for the treatment of ulcerative lesions in the lower limbs, occurring as a result of diabetic foot syndrome (DFS,. A total of 50 patients with type 2 diabetes and diabetic foot syndrome were enrolled to the study. All patients have received 30 sessions of HBOT. During the therapy blood glucose was measured and photographic documentation was carried out. All patients underwent the following procedures: medical history and socioeconomic interview, psychiatric examination, self-report and objective psychometric tests to measure anxiety and depressiveness. Based on the obtained results, we reported that patients with a greater degree of tissue damage had higher levels of depressive symptoms in the self-report tests as well as in the objective evaluation of the investigator. In terms of location of ulcerative lesions - the level of depressiveness was greater when the affected area included toes, and the level of anxiety was increased when it concerned the heel. Regarding other parameters, statistically significant correlations were not observed.

  2. Tenth European Consensus Conference on Hyperbaric Medicine: recommendations for accepted and non-accepted clinical indications and practice of hyperbaric oxygen treatment.

    Science.gov (United States)

    Mathieu, Daniel; Marroni, Alessandro; Kot, Jacek

    2017-03-01

    The tenth European Consensus Conference on Hyperbaric Medicine took place in April 2016, attended by a large delegation of experts from Europe and elsewhere. The focus of the meeting was the revision of the European Committee on Hyperbaric Medicine (ECHM) list of accepted indications for hyperbaric oxygen treatment (HBOT), based on a thorough review of the best available research and evidence-based medicine (EBM). For this scope, the modified GRADE system for evidence analysis, together with the DELPHI system for consensus evaluation, were adopted. The indications for HBOT, including those promulgated by the ECHM previously, were analysed by selected experts, based on an extensive review of the literature and of the available EBM studies. The indications were divided as follows: Type 1, where HBOT is strongly indicated as a primary treatment method, as it is supported by sufficiently strong evidence; Type 2, where HBOT is suggested as it is supported by acceptable levels of evidence; Type 3, where HBOT can be considered as a possible/optional measure, but it is not yet supported by sufficiently strong evidence. For each type, three levels of evidence were considered: A, when the number of randomised controlled trials (RCTs) is considered sufficient; B, when there are some RCTs in favour of the indication and there is ample expert consensus; C, when the conditions do not allow for proper RCTs but there is ample and international expert consensus. For the first time, the conference also issued 'negative' recommendations for those conditions where there is Type 1 evidence that HBOT is not indicated. The conference also gave consensus-agreed recommendations for the standard of practice of HBOT.

  3. Continuous home oxygen therapy.

    Science.gov (United States)

    Ortega Ruiz, Francisco; Díaz Lobato, Salvador; Galdiz Iturri, Juan Bautista; García Rio, Francisco; Güell Rous, Rosa; Morante Velez, Fátima; Puente Maestu, Luis; Tàrrega Camarasa, Julia

    2014-05-01

    Oxygen therapy is defined as the therapeutic use of oxygen and consists of administering oxygen at higher concentrations than those found in room air, with the aim of treating or preventing hypoxia. This therapeutic intervention has been shown to increase survival in patients with chronic obstructive pulmonary disease (COPD) and respiratory failure. Although this concept has been extended by analogy to chronic respiratory failure caused by respiratory and non-respiratory diseases, continuous oxygen therapy has not been shown to be effective in other disorders. Oxygen therapy has not been shown to improve survival in patients with COPD and moderate hypoxaemia, nor is there consensus regarding its use during nocturnal desaturations in COPD or desaturations caused by effort. The choice of the oxygen source must be made on the basis of criteria such as technical issues, patient comfort and adaptability and cost. Flow must be adjusted to achieve appropriate transcutaneous oxyhaemoglobin saturation correction. Copyright © 2013 SEPAR. Published by Elsevier Espana. All rights reserved.

  4. Acquiring the optimal time for hyperbaric therapy in the rat model of CFA induced arthritis.

    Science.gov (United States)

    Koo, Sung Tae; Lee, Chang-Hyung; Shin, Yong Il; Ko, Hyun Yoon; Lee, Da Gyo; Jeong, Han-Sol

    2014-01-01

    We previously published an article about the pressure effect using a rheumatoid animal model. Hyperbaric therapy appears to be beneficial in treating rheumatoid arthritis (RA) by reducing the inflammatory process in an animal model. In this sense, acquiring the optimal pressure-treatment time parameter for RA is important and no optimal hyperbaric therapy time has been suggested up to now. The purpose of our study was to acquire the optimal time for hyperbaric therapy in the RA rat model. Controlled animal study. Following injection of complete Freund's adjuvant (CFA) into one side of the knee joint, 32 rats were randomly assigned to 3 different time groups (1, 3, 5 hours a day) under 1.5 atmospheres absolute (ATA) hyperbaric chamber for 12 days. The pain levels were assessed daily for 2 weeks by weight bearing force (WBF) of the affected limb. In addition, the levels of gelatinase, MMP-2, and MMP-9 expression in the synovial fluids of the knees were analyzed. The reduction of WBF was high at 2 days after injection and then it was spontaneously increased up to 14 days in all 3 groups. There were significant differences of WBF between 5 hours and control during the third through twelfth days, between 3 hours and control during the third through fifth and tenth through twelfth days, and between 3 hours and 5 hours during the third through seventh days (P CFA injection in all groups compared to the initial findings, however, the 3 hour group showed a smaller MMP-9/MMP-2 ratio than the control group. Although enough samples were used for the study to support our hypothesis, more samples will be needed to raise the validity and reliability. The effect of hyperbaric treatment appears to be dependent upon the elevated therapy time under 1.5 ATA pressure for a short period of time; however, the long-term effects were similar in all pressure groups. Further study will be needed to acquire the optimal pressure-treatment parameter relationship in various conditions for

  5. 神经节苷脂高压氧运动统合疗法治疗脑瘫高危儿120例效果分析%Effect Analysis of 120 Cases High Risk Infants with Cerebral Palsy Treated by Ganglioside Hyperbaric Oxygen Exercise Integration Therapy

    Institute of Scientific and Technical Information of China (English)

    张德祥; 吉林; 唐宇轩

    2016-01-01

    Objective In order to investigate the clinical effect of the treatment of high risk infants with cerebral palsy in the treatment of super early stage.Methods In 2010 01 months to December 2015 period, select Sheyang County People’s hospital admitted to the high risk of cerebral palsy children as the research object, a total of 120 cases of children, divided into 2 groups. A group as the observation group, a group of treatment group, the observation group used routine intervention, treatment group with ganglioside hyperbaric oxygen motion integration therapy;and Gesell developmental scale, Wechsler child intelligence scale table were compared between the two groups of children with therapeutic effect.Results After 6 months of treatment, treatment group with large motion, adaptability, verbal, fine motor and personal social score were significantly higher than those of the observation group (P<0.01);after 12 months of treatment, treatment group with large motion, adaptability, verbal, fine motor and personal social score were significantly higher than those in the observation group (P<0.001). At the same time, treatment group with the intelligence test results is significantly higher than that of the observation group (P<0.001).Conclusion Ganglioside hyperbaric oxygen motion integration therapy in super early stage treatment of high-risk infants with cerebral palsy can effectively promote children’s neurobehavioral development and mental development, and reduce brain injury, improving the quality of life of children.%目的:探讨神经节苷脂高压氧运动统合疗法超早期干预脑瘫高危儿的临床效果。方法收集2010年01月至2015年12月射阳县人民医院收治的120例高危脑瘫儿为研究对象,观察组采用常规干预,治疗组在常规干预基础上采用神经节苷脂高压氧运动统合疗法;采用Gesell发育量表和韦氏幼儿智力量表评估比较两组患儿治疗6个月及12个月

  6. Observation on different methods of hyperbaric oxygen therapy on improving the indexes for recent therapeutic effect in patients with traumatic brain injury accompanied by arousal disorders%不同高压氧疗法治疗脑外伤觉醒障碍近期疗效观察

    Institute of Scientific and Technical Information of China (English)

    杨华林; 杨月丽

    2012-01-01

    [Objective] To observe the indexes for recent therapeutic effect of the different methods of hyperbaric oxygen (HBO) therapy on improving patients with traumatic brain injury accompanied by arousal disorders.[Methods]Sixty-five patients with traumatic brain injury accompanied by arousal disorders, who were treated in hospital in recent years, were successively selected. All the enrolled subjects accepted the HBO therapy, the pressure was 0.22 Mpa, and the stable oxygen uptake duration was 60 min/time, once or twice a day, and 6 ~12 times/week for a total of 4 weeks. The subjects were grouped according to the different HBO therapeutic methods: (1) grouping by therapeutic frequency: more frequency group (twice a day, n = 29) and fewer frequency group (twice a day, n =36). (2) grouping by therapeutic time: early therapy group (accepted therapy within 10 days, n = 35) and late therapeutic group (accepted therapy after 10 days, n = 30). All the patients were evaluated with the Glasgow Coma Scale (GCS) before and after therapy, respectively. [Results]The average days of coma and average length of stay in the more frequency group and early therapy group were obviously lower than those in the fewer frequency group and late therapeutic group (P < 0.01). The scores of GSC and DRS in the more frequency group and early therapy group after therapy were obviously better than those before therapy, and were also better than those in the fewer frequency group and late therapeutic group ( P < 0.05 ~ 0.01).[Conclusion]Early HBO therapy at more frequencies has more obvious influence on accelerating arousal and on the indexes for the recent therapeutic effect in patients with traumatic brain injury accompanied by arousal disorders.%[目的]观察不同高压氧(hyperbaric oxygen,HBO)治疗方法改善脑外伤觉醒障碍患者的近期疗效指标.[方法]连续选择近年来我院住院治疗脑外伤觉醒障碍患者65例,入选对象均接受了HBO治疗,压力为0.22 MPa

  7. 高压氧治疗对糖尿病足患者胶原合成和氮氧化合物的影响%Effect of hyperbaric oxygen therapy on collagen synthesis and nitric oxide in diabetic foot patients

    Institute of Scientific and Technical Information of China (English)

    杨振; 乔师师

    2012-01-01

    目的 探讨高压氧治疗对糖尿病足患者胶原合成和氮氧化合物(NOx)的影响.方法 纳入20例糖尿病足慢性溃疡患者,所有患者接受常规治疗,胰岛素控制血糖和抗生素控制感染.在此基础上,给予患者吸入100%的纯氧,压力为2.4个大气压,持续105 min,1周5次,连续治疗6周,共30次.检测治疗前后患者血糖、糖化血红蛋白(HbA1C)、C反应蛋白(CRP)及创面面积.此外检测血浆Ⅰ型前胶原肽(PⅠNP)和Ⅲ型前胶原肽(PⅢNP)及NOx.结果 治疗后,所有患者血糖和HbA1c水平降低(P0.05).创面愈合程度大于50%的患者治疗后NOx的水平明显升高(P0. 05). Nox level was increased in the patients with wounds surface healing more than 50% or higher (P<0. 05) , while Nox level was decreased in the patients with wounds surface healing less than 50% (P< 0. 05). Conclusion After hyperbaric oxygen therapy,the plasma P I NP and PHI NP levels are increased in diabetic foot patients, there is an optimum Nox levels for its contribution to the healing process.

  8. Hyperbaric Oxygen Treatment of Vasuter Dementia%血管性痴呆的高压氧治疗

    Institute of Scientific and Technical Information of China (English)

    吴颖; 陈桂红; 黎国雄; 滕蓬霞; 麦明霞; 何伟萍

    2002-01-01

    Objective To study the effect of treatment and treatment machanism of hyperbaric oxy-gen (HBO) for vascuter dementia. Method The research object was 96 patient with vascuter dementiathe trial which were ranged from four course to eight course were completed respectively, and statisticalanalysis was made fov this patient according to the standavd of the effect of treatment. Result Total ef-feetive ratio was 91.7% ,the differences reached very significance (P< 0.01) before and after the effectof treatment. Conclusions The effected of treatment vascuter dementia treated with hyperbaric oxygenwas apparent the machanism is teat HBO can increase in cevebral oxygenation improve anoxic braindemage, enhance the activation of neuromal cells, improve the funtionat effects on the brain.

  9. Hyperbaric oxygen therapy at different pressure levels for aphasia following craniocerebral injury:efficacy, safety and patient adherence to therapy%不同压力高压氧治疗颅脑损伤后失语症的疗效及依从性

    Institute of Scientific and Technical Information of China (English)

    李琴

    2015-01-01

    Objective To observe the clinical effect of hyperbaric oxygen (HBO) therapy at different pressure levels on aphasia after craniocerebral injury and assess the patient adherence to the therapies. Methods Thirty-one patients with aphasia after craniocerebral injury receiving 30 sessions of HBO therapy at the pressure level of 0.175 MPa and another 31 patients receiving 0.2 MPa therapy were recruited as the treatment groups 1 and 2, respectively;31 patients who refused to have HBO therapy served as the control group. All the patients received routine therapy. The therapeutic effects were assessed using Western Aphasia Battery (WAB) before and after the therapy. The WAB item and AQ scores, curative effect, and recovery time of aphasia were compared between the 3 groups. Results The total response rate was significantly lower in the control group as compared with those in treatment groups 1 and 2 (58.06% vs 83.87% and 87.1%). WAB item scores and AQ scores, curative effect, and recovery time of aphasia all showed significant differences between the control group and the two treatment groups (P0.05). Compared with 0.20 MPa HBO therapy, 0.175 MPa HBO therapy showed a better patient adherence with a significantly lowered non-adherence rate (by 31.37%) an increased partial and total adherence rates (by 13.86% and 17.51%, respectively). Conclusion HBO therapy at the pressure level of 0.175 MPa is more appropriate for treatment of aphasia after craniocerebral injury to ensure the safety, efficacy and patient compliance.%目的 探讨颅脑损伤后失语症患者给予不同压力高压氧治疗(HBO)的临床疗效及治疗依从性.方法 将接受30次HBO治疗的31例颅脑损伤后失语症患者纳入治疗1组;将2009年1月~2011年6月间接受30次HBO治疗的31例颅脑损伤后失语症患者纳入治疗2组;将2009年1月~2013年12月间拒绝HBO治疗的31例颅脑损伤后失语症患者纳入对照组.对照组给予常规的脑外科综合治疗,治疗组在采

  10. Application effect of hyperbaric oxygen in the patients with optic atrophy and influence for the hemodynamic parameters

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    Kun Zhang

    2015-01-01

    Full Text Available AIM: To observe the application effect of hyperbaric oxygen in the patients with optic atrophy and influence degree for the hemodynamic parameters.METHODS: Fifty patients with optic atrophy in our hospital from January 2012 to January 2014 were objected, they were randomly divided into control group(conventional optic atrophy treatment groupand observation group(conventional treatment and hyperbaric oxygen treatment group, each group was 25 cases. Statistical analysis of two group before and after treatment eyesight, vision acuity, visual field defect and ophthalmic artery, central retinal artery blood flow parameters were undergone.RESULTS: The sight, visual field sensitivity and field vision defect of observation group were all better than those of control group at first, second and third course after the treatment, arteriae ophthalmica and arteriae centralis retinae EDV and PSV were all higher than those of control group, PI and RI were all lower than those of control group were all significant differences(PCONCLUSION: The application effect of hyperbaric oxygen in the patients with optic atrophy is better, and the influence of treatment method for the ocular hemodynamic parameters are more active.

  11. Status analysis of hyperbaric oxygen in the treatment of peripheral facial paralysis%高压氧治疗周围性面神经麻痹的现状分析

    Institute of Scientific and Technical Information of China (English)

    赵沁; 曾宪容

    2015-01-01

    高压氧治疗是在高于一个大气压的环境中通过吸入高浓度的氧来治疗疾病的过程。周围性面神经麻痹的传统治疗方法如药物、针灸、理疗等疗效较为确切。目前运用高压氧治疗周围性面神经麻痹是一种应用较为广泛的辅助治疗方法。本研究基于不同原因造成的周围性面神经麻痹,综述了高压氧治疗周围性面神经麻痹的发展现状,主要总结了当前高压氧治疗不同原因造成的周围性面瘫的效果,并分析了高压氧治疗的时机、疗程及效果评价指标及存在的问题,对该辅助治疗手段的发展趋势进行展望。%Hyperbaric oxygen therapy indicates a process of treating diseases by inhalation of high concentrations of oxygen higher than atmospheric pressure.Traditional therapeutic methods including medication,acupuncture and moxi-bustion,and physiotherapy in the treatment of peripheral facial paralysis obtain definite effects.At present,hyperbaric oxygen therapy applying to treat peripheral facial paralysis is an adjuvant therapy widely used.Based on peripheral fa-cial paralysis by different causes,the paper comprehensively reviewed current situation of hyperbaric oxygen therapy on treating peripheral facial paralysis,mainly focused on summarizing its effects from different causes,analyzing timing, course of treatment,and indexes obtaining effects of hyperbaric oxygenation,and existing problems,and looking to the fu-ture of development tendency of adjuvant hyperbaric oxygen therapy.

  12. Investigation of the effect and mechanism of hyperbaric oxygenation therapy on neonatal hypoxic-ischemic encepha-lopathy with SPECT%新生儿缺氧缺血脑病高压氧治疗SPECT研究

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    贾少微; 易治; 廖建湘

    2001-01-01

    目的应用SPECT评价新生儿缺氧缺血脑病HBO的疗效,探讨治疗机理.方法研究对象34例新生儿,正常新生儿组3例,HBO组HIE患儿20例,对照组HIE患儿11例.2组HIE患儿在治疗前和治疗后各接受一次SPECT检查.结果治疗前SPECT示31例HIE患儿有46个大小不同的局灶性血流灌注和功能缺损或低下区.HBO组HIE患儿经1~2个疗程的HBO治疗后,脑内原有局灶性血流灌注和功能缺损或低下区缩小或消失.对照组的HIE患儿虽也有一定好转,但恢复程度不及HBO组,2组之间的疗效差异显著(P<0.01).结论 HBO治疗HIE患儿疗效显著,主要是通过增加脑组织增加局部脑血流灌注和含氧量,来改善脑细胞的缺氧状态,激发脑细胞的活性,促进损伤脑细胞的修复.%Objective To evaluate the effect of HBO on neonatal hypoxic-ischemic encephalopathy with SPECT, and to explore the mechanisms.Methods The research subjects were totally 34 newborn babies, including 3 normal neonates. The group treated with HBO included 20 babies with HIE, and the control group contained 11 HIE babies. All babies in both groups received SPECT exams before and after the treatments. Results SPECT before treatment showed 46 foci of low perfusion and functional defect or insufficiencies in 31 HIE babies. SPECT after 1-2 period of treatments of HBO therapy in HIE babies showed disappeared or reduced low perfusion and functional defect or insufficiency in the brains. The HIE babies in the control group showed improvement with less degree than HBO treated babies. There were significant differences (P<0.01) between two groups. Conclusion The effect of HBO on HIE babies were prominent. The treatment can improve the hypoxic status of brain cell through increase the regional cerebral blood flow perfusion and oxygen content of the brain tissue, then provoked the brain cells activities, and at last, enhance the repair of the injured brain cells.

  13. Effects of hyperbaric oxygen therapy in the management of chronic wounds and its correlation with CD34 ± endothelial progenitor cells%高压氧治疗下肢慢性创面愈合与外周血内皮祖细胞的相关性

    Institute of Scientific and Technical Information of China (English)

    马辕华; 雷永红; 周敏; 李雪; 赵宏宇

    2011-01-01

    Objective To evaluate the effects of hyperbaric oxygen(HBO)therapy in the management of chronic wound and observe the correlation between wound healing and CD34 + endothelial progenitor cells(EPCs).Methods A total of 119 patients with chronic wound in lower extremities lasting >3 months were recruited for this randomized,single-center,placebo-controlled clinical trial.The changes of CD34 + average count before and after HBO therapy were detected by flow cytometry(FACS).There were 97 patients on long-term HBO therapy and in 22 patients on hyperbaric air therapy as control group.The CD34/Scal-1 + and CD34/CXCR4 dual-positive populations of gated cell were determined respectively by FACs.The outcomes of two groups were compared.Treatment was administered within a single-place hyperbaric chamber for 90-main daily(session duration 120 main)for 5 days a week for 4 weeks (20 treatment sessions).Results The wound size decreased at the4-week end point(62.7% +22.3% in the HBO group vs 34.4% +20.6% in the control group,P <0.05).Mter 10 episodes of HBO therapies for chronic non-healing wound,the peripheral CD34 + EPCs average count rose from 0.24% + 0.03% at pretreatment to 1.32% ±0.05% while the number was 1.75% + 0.17% after 20 episodes of HBO(P < 0.05)Both were significantly different from that of the patients at pre-treatment.However the overall circulating white cell count was not significantly elevated.The CD34/Scal-1 + and CD34/CXCR4 dual-positive populations of gated cell in HBO group were 5.8 and 5.2 folds than those at pre-treatment respectively.The number of EPCs was positively correlated with wound healing in lower extremities(correlation coefficient 0.84 ; P < 0.01).Conclusion Adjunctive treatment of HBO facilitates the healing of chronic non-healing wound in selected patients through the mobilization of EPCs.%目的 探讨高压氧(HBO)对中国人下肢创伤后小腿部慢性创面愈合的影响,以及创

  14. Signaling pathways involved in HSP32 induction by hyperbaric oxygen in rat spinal neurons

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    Guoyang Huang

    2016-12-01

    Full Text Available Spinal cord injury (SCI is a debilitating disease, effective prevention measures are in desperate need. Our previous work found that hyperbaric oxygen (HBO preconditioning significantly protected rats from SCI after stimulated diving, and in vitro study further testified that HBO protected primary cultured rat spinal neurons from oxidative insult and oxygen glucose deprivation injury via heat shock protein (HSP 32 induction. In this study, underlying molecular mechanisms were further investigated. The results showed that a single exposure to HBO significantly increased intracellular levels of reactive oxygen species (ROS and nitric oxide (NO and activated MEK1/2, ERK1/2, p38 MAPK, CREB, Bach1 and Nrf2. The induction of HSP32 by HBO was significantly reversed by pretreatment neurons with ROS scavenger N-Acetyl-L-cysteine, p38 MAPK inhibitor or Nrf2 gene knockdown, enhanced by MEK1/2 inhibitors or gene knockdown but not by ERK1/2 inhibitor. CREB knockdown did not change the expression of HSP32 induced by HBO. N-Acetyl-L-cysteine significantly inhibited the activation of MEK1/2, ERK1/2, p38 MAPK, and Nrf2. Activation of Nrf2 was significantly inhibited by p38 MAPK inhibitor and the nuclear export of Bach1 was significantly enhanced by MEK1/2 inhibitor. The results demonstrated that HBO induces HSP32 expression through a ROS/p38 MAPK/Nrf2 pathway and the MEK1/2/Bach1 pathway contributes to negative regulation in the process. More importantly, as we know, this is the first study to delineate that ERK1/2 is not the only physiological substrates of MEK1/2.

  15. 高压氧技术在青少年重度脑损伤治疗中的应用%Role of hyperbaric oxygen therapy in severe head injury of teenagers

    Institute of Scientific and Technical Information of China (English)

    王林

    2014-01-01

    Objective A brain injury results in a temporary or permanent impairment of cognitive ,emotional ,and/or physical function , the outcome of which is difficult to predict .Prognostic instruments are not precise enough to reliably predict individual patient 's mortality and long-term functional status .The purpose of this article is to provide a guidance to the strengths and limitations of the use of hyper -baric oxygen therapy ( HBOT) in treating pediatric patients with severe brain injury .Methods We studied 56 patients of head injury , 28 of whom received HBOT.Only cases with severe head injury[Glasgow Coma Scale (GCS) <8]with no other associated injury were included in the study group.After an initial period of resuscitation and conservative management (10~12 days),all were subjected to three sessions of HBOT at 1-week interval .This study group was compared with a control group of similar severity of head injury ( GCS<8).Results The study and control groups were compared in terms of duration of hospitalization ,GCS,disability reduction,and so-cial behavior .Patients who received HBOT were significantly better than the control group on all the parameters with decreased hospital stay,better GCS,and drastic reduction in disability.Conclusions Among teenagers with traumatic brain injury ,the application of HBOT significantly improves the outcome and quality of life and reduces the risk of complications .%目的:脑损伤可导致暂时性或永久性的认知,情感障碍和/或机体功能损伤,要预测脑损伤可能造成的后果是有难度的。另外预后监测工具也并不能够精确可靠地预测个体病人的死亡率以及长期的功能状态。该文的目的在于分析高压氧技术( HBOT)对青少年重度脑损伤治疗的应用优势及局限性。方法该文研究了56例脑损伤患者情况,其中28例接受了高压氧治疗。治疗组中只包括无其它合并伤的重度脑损伤病例[格拉斯哥昏迷评分(GCS)

  16. 电针配合高压氧治疗脑卒中偏瘫患者50例%Electro- acupuncture combined hyperbaric oxygen treating hemiplegia after stroke in 50 cases

    Institute of Scientific and Technical Information of China (English)

    张志刚; 孙毓

    2003-01-01

    BACKGROUND:Motor obstacle of limbs directly resulted from hemiplegia after stroke seriously affect patients′ daily work and living.Conventional medicine treatment can improve the function of hemiplegic limbs at some degree, but more and more studies confirm that conventional acupuncture therapy is an effective method to improve motor function of limbs.By point stimulating channel system, acupuncture therapy can regulate qi and smooth channel system, thus regulate whole body to achieve the goal of curing hemiplegia. Acupuncture combined with hyperbaric oxygen therapy can accelerate regeneration of cerebral cells, and promote the recovery of motor function of paralyzed limbs.

  17. Can hyperbaric oxygenation decrease doxorubicin hepatotoxicity and improve regeneration in the injured liver?

    Science.gov (United States)

    Firat, Ozgur; Kirdok, Ozgur; Makay, Ozer; Caliskan, Cemil; Yilmaz, Funda; Ilgezdi, Savas; Karabulut, Bulent; Coker, Ahmet; Zeytunlu, Murat

    2009-01-01

    Portal vein embolization is used in the treatment of hepatocellular cancer, with the purpose of enhancing resectability. However, regeneration is restricted due to hepatocellular injury following chemotherapeutics (e.g. doxorubicin). The aim of this study was to investigate whether hyperbaric oxygenation (HBO) can alleviate the hepatotoxicity of chemotherapy and improve regeneration in the injured liver. Rats were allocated to four experimental groups. Group I rats were subjected to right portal vein ligation (RPVL); rats in groups II and III were administered doxorubicin prior to RPVL, with group III rats being additionally exposed to HBO sessions postoperatively; group IV rats was sham-operated. All rats were sacrificed on postoperative day 7, and liver injury was assessed by measuring alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels. Protein synthetic ability was determined based albumin levels and liver regeneration by the mitotic index (MI). The AST and ALT values of group II rats were significantly higher than those of group I, but not those of group III. Rats treated with doxorubicin and HBO (groups II and III) showed slightly but not significant differences in albumin levels than those subjected to only RPVL or sham-operated. The MI was significantly increased in groups I, II, and III, with the MI of group III rats significantly higher than those of group I rats. Based on our results, we conclude that HBO treatment has the potential to diminish doxorubicin-related hepatotoxicity and improve regeneration in the injured liver.

  18. Impact of Hyperbaric Oxygenation on the Phagocytosis-Stimulating Function of the Operated Liver

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    P. N. Savilov

    2008-01-01

    Full Text Available Objective: to study the ability of hyperbaric oxygenation (HBO to eliminate impaired phagocytosis-stimulating hepatic function caused by hepatectomy (HE. Material and methods. Experiments were conducted on 82 outbred female albino rats exposed to HE (15—20% of the organ mass and HBO at 3 ata for 50 min once daily three times within the first three days after surgery. The capacities of neutrophils and monocytes of arterial (aorta and venous (portal vein, hepatic veins blood to ingest and digest S.aureus were investigated. Results: Under HBO, the inhibitory impact of HE on the phagocytosis-stimulating ability of the liver to S.aureus was limited for neutrophils and completely precluded for monocytes. In the posthyperoxic period, the phagocytosis-stimulating function of the operated liver was found to be active against the microbe being examined for both types of phagocytes. This was attended by inhibition of the anhepatic mechanisms responsible for the amplified phagocytic activity of neutrophils and monocytes, which were triggered in HE. HBO selectively regulated the arterial and venous blood content of neutrophils, by ingesting and digesting S.aureus as much as possible. HBO prevented the post-HE delay of the neutrophils and monocytes which actively englobed S.aureus in the operated organ. Conclusion: HBO eliminates HE-induced impairment of phagocytosis-stimulating function of the liver and creates conditions for its delayed activation by day 11 posthy-peroxia. Key words: hyperoxia, phagocytosis, regulation, liver, resection.

  19. Effect of hyperbaric oxygen profiles on the bond strength of repaired composite resin.

    Science.gov (United States)

    Mossa, Hossam; ElKhatat, Essam; Hassan, Ahmed M; Baroudi, Kusai; Beshr, Khaled

    2016-04-01

    This study was performed to evaluate the bond strength of repaired three types of composite resins under various hyperbaric oxygen (HBO) profiles with various session numbers. Sixty specimens of three types of composite resin (nanofilled composite, nanohybrid composite and microfilled composite) each type of composite was divided into four group according to various profiles of HBO treatment (control, 2bar, 3 bar and 5 bar). Then, the specimens were repaired; thermocycled, the tensile bond strength were measured. Then the data were analyzed by One-way ANOVA followed by Tukey's post hoc test (α = 0.05). The highest bond strength was obtained for the repaired nanofilled composite resin specimens while; the lowest bond strength was obtained for the repaired microfilled composite resin specimens. The highest tensile bond strength was recorded for the specimens who treated with the highest pressure of HBO. The bond strength of repaired nanofilled composite resins is better than the other types of composite resin. The highest pressure of HBO, the highest bond strength of repaired composite resins.

  20. Hyperbaric treatment

    Science.gov (United States)

    Amoroso, Michael T.

    1990-01-01

    Viewgraphs on hyperbaric treatment are presented. Topics covered include: hyperbaric treatment - purpose; decompression sickness; sources of decompression sickness; physical description; forms of decompression sickness; hyperbaric treatment of decompression sickness; and duration of treatment.

  1. Infection Agents Detected with Wound Culture in Patients with Diabetic Foot who will Undergo Hyperbaric Oxygen Treatment

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    Gurkan Mert

    2012-04-01

    Full Text Available AIM: We aimed to obtain the knowledge of appropriate antibiotic therapy and to make a contribution to improving treatment efficacy by conducting a microbiological study of diabetic foot ulcers. METHOD: 30 patients (18 male and 12 female with diabetic foot ulcer applying to our center for hyperbaric oxygen (HBO treatment in 2010 were enrolled in this study. The wounds were graded according to Meggitt-Wagner classification system. Wound cultures were obtained before starting antibiotic therapy and HBO treatment. Phoenix system (Becton Dickinson, USA and Kirby-Bauer disk diffusion antibiotic sensitivity testing were used in order to detect the antimicrobial susceptibility of the infection agents. The number of HBO sessions, glycemic control and treatment results were assessed. RESULTS: Mean age of the patients was 61.3 years (range: 35-83. 24 patients had a good glycemic control and 6 patients had not. The patients were given 5 to 55 HBO sessions (mean: 20. Of the 30 patients 19 (63.33% recovered from the infection but 11 (36.67% have not responded to the treatment. 14 different infectious agents were detected in diabetic foot ulcers we examined. Gram-positive agents were isolated in 12 (40% out of 30 wound cultures and gram-negative agents were isolated in 18 (60% wound culture. Pseudomonas aeruginosa was predominantly isolated and the other agents isolated were enterococcus faecalis, klebsiella pneumoniae, staphylococcus aureus and escherichia coli. CONCLUSION: The outcomes can not represent the general population rates due to the restriction factors. They give only an idea about the probability of infectious agent spectrum in diabetic foot ulcers and their antibiotic susceptibility. We want to attract attention to the fact that although pseudomonas aeruginosa infections are mostly encountered in hospital, they can also be acquired from the community and it will be useful to develop appropriate antibiotic policies and treatment protocols. [TAF

  2. Comparative analysis of lower extremities tissue perfusion by the use of perfusion scintigraphy method after hyperbaric oxygenation and lumbar sympathectomy

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    Zoranović Uroš

    2009-01-01

    Full Text Available Background/Aim. Lumbar syphatectomy (LS increases pheripheral blood flow primarily by the arteriolar vasodilatation within the skin vascular net. Increase in tissue nutrition takes place only in the distal blood vessels of the skin. Nevertheless, in some patients sympathectomy brings about improvement in ischemic ulcerations healing. Hyperbaric oxigenation (HBO is a medical treatment in which a patient breathes 100% oxygen under pressure higher than atmospheric implemented in special units allowing the whole body be in a chamber. The aim of the study was to determine efficacy of the applied therapies for the treatment of inoperable occlusive lower extremities (LE arteries diseases according to the obtained results. Methods. The study included 30 patients divided into two groups (15 patients each in which stenosis level of the lower extremities arteries had been determined using aortography due to further treatment with HBO and LS. All the patients were clinically examined, their objective condition evaluation based on claudication distance, pain in rest, skin and skin adnexa atrophy, and temperature and LE functionality, as well as exposed to perfusion scintigraphy prior to the treatment and within 30 days after the treatment finishing. Results. Analyzing patients' status prior to and after the treatments applied the number of patients with obvious improvement was higher in those treated by HBO than those treated by LS. Measuring claudication distance revealed significantly greater changes in patients treated by HBO (from 178.57 m to 754.76 m than in those treated by LS (from 229 m to 253 m. Other clinical symptoms, such as parasthesia, status of the skin adnexes (hair, nails, skin colour and temperature were also improved after the treatment by HBO. Conclusion. The results obatined in this study confirm the advantages of HBO over LS in therapy of inoperable occlusive LE disease, so LS could be definitely abandoned as a choice for treating such

  3. Hydrostatic Hyperbaric Chamber Ventilation System

    Science.gov (United States)

    Sarguisingh, Miriam J.

    2012-01-01

    The hydrostatic hyperbaric chamber (HHC) represents the merger of several technologies in development for NASA aerospace applications, harnessed to directly benefit global health. NASA has significant experience developing composite hyperbaric chambers for a variety of applications. NASA also has researched the application of water-filled vessels to increase tolerance of acceleration forces. The combination of these two applications has resulted in the hydrostatic chamber, which has been conceived as a safe, affordable means of making hyperbaric oxygen therapy (HBOT) available in the developing world for the treatment of a variety of medical conditions. Specifically, HBOT is highly-desired as a possibly curative treatment for Buruli Ulcer, an infectious condition that afflicts children in sub-Saharan Africa. HBOT is simply too expensive and too dangerous to implement in the developing world using standard equipment. The HHC technology changes the paradigm. The HHC differs from standard hyperbaric chambers in that the majority of its volume is filled with water which is pressurized by oxygen being supplied in the portion of the chamber containing the patient s head. This greatly reduces the amount of oxygen required to sustain a hyperbaric atmosphere, thereby making the system more safe and economical to operate. An effort was taken to develop an HHC system to apply HBOT to children that is simple and robust enough to support transport, assembly, maintenance and operation in developing countries. This paper details the concept for an HHC ventilation and pressurization system to provide controlled pressurization and adequate washout of carbon dioxide while the subject is enclosed in the confined space during the administration of the medical treatment. The concept took into consideration operational complexity, safety to the patient and operating personnel, and physiological considerations. The simple schematic, comprised of easily acquired commercial hardware

  4. The NO-cGMP-PKG signal transduction pathway is involved in the analgesic effect of early hyperbaric oxygen treatment of neuropathic pain.

    Science.gov (United States)

    Ding, Yuanyuan; Yao, Peng; Hong, Tao; Han, Zhenkai; Zhao, Baisong; Chen, Weimin

    2017-12-01

    Hyperbaric oxygen (HBO) has the potential to relieve neuropathic pain. The purpose of this study was to determine whether the NO-cGMP-PKG signaling pathway is involved in the analgesic effects of early hyperbaric oxygen treatment of neuropathic pain in rats. Rats were randomly grouped for establishment of chronic constriction injury (CCI) models. Intrathecal catheters were inserted and 2.5ATA HBO therapy was administered from day 1 post-surgery for 60 minutes daily, continuously for 5 days; menstruum NS, DMSO, NO synthase(NOS) nonspecific inhibitor (L-NAME), soluble guanylyl cyclase(sGC) inhibitor (ODQ) and protein kinase G(PKG) inhibitor (KT5823) were administered intrathecally 30 minutes prior to HBO therapy. Pain-related behaviors in rats were observed at specific time points. Western blot and real-time RT-PCR were used to observe the expressions of PKG1 mRNA and protein in the spinal dorsal horn. Compared with the CCI group, HBO could significantly relieve mechanical and thermal hyperalgesia in rats. After intrathecal administration of L-NAME, ODQ and KT5823, effects of HBO on relieving hyperalgesia in rats were reversed (P < 0.05 vs. HBO), and expression of PKG1 mRNA and protein decreased in the spinal dorsal horn of the animals (P < 0.05 vs. HBO). Early HBO therapy could significantly improve symptoms of hyperalgesia of neuropathic pain in rats, possibly via activation of the NO-cGMP-PKG signaling transduction pathway.

  5. Hyperbaric oxygen preconditioning attenuates hyperglycemia enhanced hemorrhagic transformation after transient MCAO in rats

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    Soejima Yoshiteru

    2012-04-01

    Full Text Available Abstract Background Hemorrhagic transformation (HT can be a devastating complication of ischemic stroke. Hyperbaric oxygen preconditioning (HBO-PC has been shown to improve blood-brain barrier (BBB permeability in stroke models. The purpose of this study is to examine whether HBO-PC attenuates HT after focal cerebral ischemia, and to investigate whether the mechanism of HBO-PC against HT includes up-regulation of antioxidants in hyperglycemic rats. Methods Male Sprague-Dawley rats (280-320 g were divided into the following groups: sham, middle cerebral artery occlusion (MCAO for 2 h, and MCAO treated with HBO-PC. HBO-PC was conducted giving 100% oxygen at 2.5 atm absolute (ATA, for 1 h at every 24 h interval for 5 days. At 24 h after the last session of HBO-PC, rats received an injection of 50% glucose (6 ml/kg intraperitoneally and were subjected to MCAO 15 min later. At 24 h after MCAO, neurological behavior tests, infarct volume, blood-brain barrier permeability, and hemoglobin content were measured to evaluate the effect of HBO-PC. Western blot analysis of nuclear factor erythroid 2-related factor 2 (Nrf2 and heme oxygenase-1 (HO-1 was evaluated at multiple time-points before and after MCAO. Results HBO-PC improved neurological behavior test, and reduced infarction volume, HT and Evans blue extravasation in the ipsilateral hemisphere at 24 h after MCAO. Western blot analysis failed to demonstrate up-regulation of Nrf2 in HBO-PC group before and after MCAO. Paradoxically, HBO-PC decreased HO-1 expression at 24 h after MCAO, as compared with htMCAO group. Conclusions HBO-PC improved neurological deficits, infarction volume, BBB disruption, and HT after focal cerebral ischemia. However, its mechanism against focal cerebral ischemia and HT may not include activation of Nrf2 and subsequent HO-1 expression.

  6. Protective effects of hyperbaric oxygen and iloprost on ischemia/reperfusion-induced lung injury in a rabbit model

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    Bozok Ş

    2012-06-01

    Full Text Available Abstract Background The role of multiorgan damage in the mortality caused by ischemic limb injury is still not clarified. The objective of this study was to examine the potential protective effects of hyperbaric oxygen (HBO and iloprost (IL therapy on lung damage induced by limb ischemia/reperfusion injury in a rabbit model, using both biochemical and histopathological aspects. Methods Forty New Zealand white rabbits were randomly allocated into one of five study groups: HBO group (single session of HBO treatment; IL group (25 ng/kg/min infusion of IL; HBO + IL group (both HBO and IL; Control group (0.9% saline only; and a sham group. Acute hind limb ischemia-reperfusion was established by clamping the abdominal aorta for 1 h. HBO treatment and IL infusion were administrated during 60 min of ischemia and 60 min of reperfusion period. Blood pH, partial pressure of oxygen, partial pressure of carbon dioxide and levels of bicarbonate, sodium, potassium, creatine kinase, lactate dehydrogenase, and tumor necrosis factor alpha were determined at the end of the reperfusion period. Malondialdehyde was measured in the plasma and lung as an indicator of free radicals. After sacrifice, left lungs were removed and histopathological examination determined the degree of lung injury. Results In the control group, blood partial pressure of oxygen and bicarbonate levels were significantly lower and creatine kinase, lactate dehydrogenase, malondialdehyde and tumor necrosis factor-α levels were significantly higher than those of the HBO group, IL group, HBO + IL group and sham group. Similarly, the malondialdehyde levels in the lung tissue and plasma levels were significantly lower in the treatment groups compared with the control group. The extent of lung injury according to the histological findings was significantly higher in the control group. Conclusions These results suggest that both HBO and IL therapies and their combination might be

  7. The Effect of Hyperbaric Oxygen on the Growth of Rhizopus nigricans.

    Science.gov (United States)

    1980-12-01

    MEN T , lhe aSttr0 I’to 1’r54 is 1l1,5 20. ii dillere trom Report) IS SUPPLEMENTARY NOTES 9 K ES WORDS (Continlt, o, reverse sIe it necessary and...identify by block number) Impression Chamber Medical Mycology Oxygen Therapy (ompression Therapy Mucor Phycomycosis hvp )erbaric Medicine Mucormycosis

  8. 高压氧加药物综合治疗突发性耳聋疗效分析%Therapeutic Effect of Hyperbaric Oxygen Combined with Medical Treatment on Sudden Deafness

    Institute of Scientific and Technical Information of China (English)

    黄红星; 杨立; 黄远; 唐梓轩; 赵之栋

    2011-01-01

    目的 探讨高压氧联合药物治疗突发性耳聋(sudden deafness,SD)的疗效.方法 2008年2月- 2010年7月,对174例SD患者采用高压氧(治疗压力0.2 MPa)及配合扩血管、营养神经等药物进行治疗,并观察其疗效.结果 高压氧联合药物治疗SD总有效率为85.7%,SD的发病就诊时间是影响预后的主要因素,发病就诊时间≤7d时,治疗有效率可达95.6%;≥15 d时,疗效明显降低.结论 高压氧联合药物治疗SD疗效确切,且高压氧治疗越早疗效越好.%Objective To observe the therapeutic effect of hyperbaric oxygen combined with medical treatment on sudden deafness. Methods Between February 2008 and July 2010, 174 patients with sudden deafness were treated by a combined therapy, including hyperbaric oxygen and medicals. The therapeutic effect was analyzed. Results The total effective rate was 85. 7%. The simultaneous phenomenon such as vertigo and vomiting and onset-diagnosis duration were the two major factors affecting the prognosis. When the onset-diagnosis duration was <[7 days, the effective rate reached 95. 6%; when the onset-diagnosis duration was≥15 days, the therapeutic effect decreased significantly. Conclusion Hyperbaric oxygen combined with medical treatment is effective for sudden deafness, and the hyperbaric oxygen treatment should be performed as earlier as possible.

  9. Hyperbaric oxygenation after portal vein emobilization for regeneration of the predicted remnant liver.

    Science.gov (United States)

    Uwagawa, T; Unemura, Y; Yamazaki, Y

    2001-09-01

    Liver failure often develops after extensive liver resection. Preoperative portal vein embolization to induce compensatory hypertrophy in the predicted remnant liver decreases clinical complications after hepatectomy. The aim of this study was to examine whether hyperbaric oxygenation (HBO) after portal vein embolization increases compensatory hypertrophy of the predicted liver remnant. We performed portal vein ligation and HBO in rats to investigate whether HBO after portal vein embolization increases compensatory hypertrophy of the predicted remnant liver. Rats were divided into four groups that underwent (1) laparotomy only (control group); (2) right portal vein ligation (RPL group); (3) RPL followed by HBO at 2 atm (HBO-2 atm group; 1 h/day, 5 days/week for 2 weeks); or (4) RPL followed by HBO at 3 atm (HBO-3 atm group). Laparotomy was repeated after 2 weeks in each group; serum levels of albumin and hepatocyte growth factor (HGF) were measured, and the ratio of the weights of nonligated to ligated hepatic segments and the percentage of hepatocytes expressing proliferating cell nuclear antigen (PCNA) in ligated hepatic segments were determined. In rats that had received HBO after RPL, serum levels of HGF, weight ratios of nonligated to ligated hepatic segments, and the percentage of PCNA-positive hepatocytes in nonligated liver were significantly higher than those in the control group. Furthermore, rats that had undergone 3-atm HBO after RPL had significantly higher serum levels of HGF and percentages of PCNA-positive hepatocytes in nonligated hepatic segments. Preoperative HBO after portal vein embolization may be useful for inducing compensatory hypertrophy of the predicted remnant liver. Copyright 2001 Academic Press.

  10. Effects of hyperbaric oxygen preconditioning on ischemia-reperfusion inflammation and skin flap survival

    Institute of Scientific and Technical Information of China (English)

    QI Zheng; GAO Chun-jin; WANG You-bin; MA Xue-mei; ZHAO Ling; LIU Fu-jia; LIU Xue-hua

    2013-01-01

    Background Hyperbaric oxygen preconditioning (HBO) is a new method of ischemia preconditioning.In this study,we examined its effects on skin flap survival and the mechanisms involved.Methods Thirty-six rats were divided into three groups:HBO preconditioning,control,and sham groups.An extended epigastric adipocutaneous flap based on the right superficial epigastric artery and vein was raised.A 3-hour period of flap ischemia was induced by clamping the pedicle vessels with a microvascular clamp.At the end of ischemia induction,the clamp was removed and the flap was resutured.Rats in the HBO preconditioning group were treated with HBO four times before surgery.Microcirculation in the skin flap was measured on postoperative days 1,3 and 5.The size of the flap was measured on postoperative day 5,before the animals were sacrificed.Samples of the skin flap were prepared and stained with hematoxylin and eosin.The levels of tumor necrosis factor (TNF)-o,interleukin (IL)-1β,and IL-6 in the flap samples were measured.Results Surviving flap size was significantly higher in the HBO preconditioning group compared with controls,with a reduced inflammatory response and increased perfusion.IL-1,TNF-α,and IL-6 levels in the HBO preconditioning group were lower than in controls.Conclusions HBO preconditioning improved flap survival in this ischemia-reperfusion rat model.The mechanisms responsible for this effect may relate to attenuation of the inflammatory response and increased flap perfusion following HBO preconditioning.

  11. 高压氧综合治疗对不完全颈髓损伤术后恢复的影响%Effects of comprehensive hyperbaric oxygen therapy on the recovery of patients following surgery of incomplete cervical spinal injury

    Institute of Scientific and Technical Information of China (English)

    李倩; 张志武; 董平; 余芳; 许文根; 卢一生; 李玢

    2014-01-01

    Objective To investigate the effects of comprehensive hyperbaric oxygen (HBO) therapy on the recovery of patients following surgery of incomplete cervical spinal injury.Methods A retrospective analysis was made on the clinical data of 78 cases of incomplete cervical spinal injury by trauma collected from the medical file of our hospital from June 2010 to June 2012.All the patients had complete follow-up medical data,and no statistical significance could be noted in age,gender,injury sites,seriousness of injury etc.In addition,all the patients underwent nerve decompression and internal fixation within 2 weeks after injury.With the knowledge and consent of the patients and following approval by the Hospital Ethics Committee,the patients were divided into the HBO group (40 cases) and non-HBO(NHBO)group (38 cases).Following surgery,the patients in the NHBO group were treated with only routine treatment,while the patients in the HBO group received HBO therapy in addition to routine treatment.American Spinal Cord Injury Association (ASIA) Scores and Barthel's Index (BI) were respectively used to evaluate the spinal cord function and their daily life activity,before treatment,1 month and 3 months after treatment,6 months and 1 year after surgery.Results Total effective rates for the HBO group and the NHBO group were 90.0% and 78.9%,with statistical significance,when comparisons were made between the 2 groups (P < 0.05).Following 1 month and 3 months of treatment,and after 6 months and l year of surgery,statistical significance could be noted in the scores of ASIA and BI between the 2 groups (P < 0.05),with the therapeutic effect of the HBO group being superior to that of the NHBO group.Recovery was most obvious in the first month after surgery.One month after surgery,ASIA scores,motor function scores and Barthel scores for both the HBO group and the NHBO group were all significantly higher,as compared with those before treatment,with the scores of the HBO group

  12. HYPERBARIC OXYGEN IN TREATING DIABETIC FOOT AND CORRESPONDING NURSING MEASURES%高压氧综合治疗糖尿病足的疗效观察及护理

    Institute of Scientific and Technical Information of China (English)

    刘锦萍

    2009-01-01

    目的 探讨高压氧治疗糖尿病足的临床疗效和护理要点.方法 将80例糖尿病足患者随机分为两组,常规治疗组(对照组)40例采用控制血糖、抗感染、加强营养、改善微循环等常规治疗;高压氧治疗组(治疗组)40例在常规治疗基础上应用高压氧治疗40 d.观察比较两组治疗前后症状改善情况.结果 治疗组症状改善情况明显优于对照组(P<0.05).结论 应用高压氧治疗糖尿病足疗效确切,精心、细致的护理则是保证高压氧治疗顺利进行的关键.%Objective To investigate the hyperbaric oxygen treatment of diabetic foot and thecorresponding nursing measures.Methods 80 patients with diabetic foot were randomly divided into the conventional treatment group(n=40) and the hyperbaric oxygen treatment group(n=40).Blood sugar control,anti-infection,nutrition,improvement of microcirculation and other conventional treatment were applied to the control group.Hyperbaric oxygen therapy was used for 40 days based on conventional treatment in the treatment group.The improvement of symptoms were observed and compared between the two groups before and after treatments.Results The improvement of symptoms of the treatment group was significantly higher than that of the control group(P<0.05).Conclusion The application of oxygen treat hyperbaric oxegen treatment of diabetic footcan produce good curative effects.Good nursing care is the key to ensure the smooth progress of hyperbaric oxygen therapy.

  13. 高压氧舱治疗新生儿缺血缺氧性脑病的临床护理%Nursing Experience of Hyperbaric Oxygen in the Treatment of Neonatal Hypoxic Ischemic Encephalopathy

    Institute of Scientific and Technical Information of China (English)

    王献梅; 林杨; 张秋迟

    2015-01-01

    目的总结高压氧舱治疗新生儿缺血缺氧性脑病( HIE)的护理措施。方法选取69例新生儿缺血缺氧性脑病患儿作为研究对象,总结高压氧治疗期间的护理措施。结果通过积极治疗和精心护理,患儿脑水肿及高颅压症状明显改善。结论高压氧治疗新生儿缺血缺氧性脑病必须严格遵守和高度重视高压氧治疗的护理技术管理,以减轻患儿痛苦,缩短病程,改善预后,提高生存质量。%Objective Conclusion hyperbaric treatment of neonatal hypoxic ischemia encephalopathy (HIE) nursing measures.Methods Select 69 cases of neonatal hypoxic ischemia encephalopathy children as the research object,summarizes the nursing measures during the hyperbaric oxygen therapy.Results Through active treatment and careful nursing,cerebral edema and high cranial pressure symptoms improved significantly.Conclusion Hyperbaric oxygen treatment of neonatal hypoxic ischemia encephalopathy must strictly abide by and at aches great importance to the hyperbaric oxygen treatment of nursing management technology,to al eviate the children with pain,shorten the course of the disease and improve prognosis,improve the quality of survival.

  14. Hyperbaric oxygen treatment for inflammatory bowel disease: a systematic review and analysis

    Directory of Open Access Journals (Sweden)

    Rossignol Daniel A

    2012-03-01

    Full Text Available Abstract Background Traditionally, hyperbaric oxygen treatment (HBOT has been used to treat a limited repertoire of disease, including decompression sickness and healing of problem wounds. However, some investigators have used HBOT to treat inflammatory bowel disease (IBD, including Crohn's disease and ulcerative colitis. Methods Comprehensive searches were conducted in 8 scientific databases through 2011 to identify publications using HBOT in IBD. Human studies and animal models were collated separately. Results Thirteen studies of HBOT in Crohn's disease and 6 studies in ulcerative colitis were identified. In all studies, participants had severe disease refractory to standard medical treatments, including corticosteroids, immunomodulators and anti-inflammatory medications. In patients with Crohn's disease, 31/40 (78% had clinical improvements with HBOT, while all 39 patients with ulcerative colitis improved. One study in Crohn's disease reported a significant decrease in proinflammatory cytokines (IL-1, IL-6 and TNF-alpha and one study in ulcerative colitis reported a decrease in IL-6 with HBOT. Adverse events were minimal. Twelve publications reported using HBOT in animal models of experimentally-induced IBD, including several studies reporting decreased markers of inflammation or immune dysregulation, including TNF-alpha (3 studies, IL-1beta (2 studies, neopterin (1 study and myeloperoxidase activity (5 studies. HBOT also decreased oxidative stress markers including malondialdehyde (3 studies and plasma carbonyl content (2 studies, except for one study that reported increased plasma carbonyl content. Several studies reported HBOT lowered nitric oxide (3 studies and nitric oxide synthase (3 studies and one study reported a decrease in prostaglandin E2 levels. Four animal studies reported decreased edema or colonic tissue weight with HBOT, and 8 studies reported microscopic improvements on histopathological examination. Although most

  15. Does hyperbaric oxygen treatment have the potential to increase salivary flow rate and reduce xerostomia in previously irradiated head and neck cancer patients? A pilot study

    DEFF Research Database (Denmark)

    Forner, Lone; Hansen, Ole Hyldegaard; von Brockdorff, Annet Schack

    2011-01-01

    Irradiated head and neck cancer survivors treated in the Hyperbaric Oxygen (HBO) Unit, Copenhagen University Hospital, spontaneously reported improvement of radiation-induced dry mouth feeling. The aim of this pilot study was to evaluate salivary flow rate and xerostomia before and after HBO...

  16. 高压氧对高血压性心脏病左室重构的影响%Effects of Hyperbaric Oxygen on Left Ventricular Reconstruction of Patients with Hypertensive Heart Disease

    Institute of Scientific and Technical Information of China (English)

    彭志坚; 李继锋; 章少波; 蔡建生; 林炳钦; 许锦叶

    2011-01-01

    目的:探讨高压氧对高血压性心脏病左室重构的影响.方法:随机将80例高血压性心脏病患者分为两组,其中40例在常规药物治疗基础上加用高压氧治疗为治疗组,40例应用常规药物治疗为对照组,治疗前后进行彩色多普勒超声检测.随访6个月复合心血管事件发生率.结果:治疗组行高压氧治疗后,室间隔舒张末期厚度(IVSD)、左室后壁舒张末期厚度(LVPWD)、左室心肌重量指数(LVMI)明显降低(P﹤0.001),与对照组比较有显著性差异(P﹤0.05).随访6个月,治疗组发生复合心血管事件较对照组减少且有显著性差异(P﹤0.05).结论:高压氧治疗高血压性心脏病能逆转高血压性心脏病左室肥厚(LVH),并减少心血管事件发生率.%Objective: To study the effects of hyperbaric oxygen on left ventricular reconstruction in patients with hypertensive heart disease. Method: 80 patients with hypertensive heart disease were randomly divided into treatment group and control group. Conventional therapy was given to the patients of both groups. In addition, hyperbaric oxygen therapy was applied to those in treatment group. After 6 months,Doppler ultrasound recordings were obtained from all patients to determine the diastolic ventricular septum thickness ( IVSD ), left ventricular end diastolic wall thickness ( LVPWD ) and left ventricular mass index ( LVMI). Result: After hyperbaric oxygen therapy, IVSD, LVPWD and LVMI significantly decreased ( P <0.001) in treatment group, and there's significant differences between two groups (P < 0.05 ). Follow-upfor 6 months, the treatment group occured relatively complex cardiovascular events less and there's significance difference ( P < 0.05 ) between two groups. Conclusion: Hyperbaric oxygen therapy could reverse the hypertensive heart disease in patients with left ventricular hypertrophy ( LVH ), and reduce the incidence of cardiovascular events.

  17. Argon plasma coagulation and hyperbaric oxygen therapy in chronic radiation proctopathy, effectiveness and impact on tissue toxicity Argón plasma y oxígeno hiperbárico para el control de la rectorragia crónica secundaria a la proctopatía por radiación

    Directory of Open Access Journals (Sweden)

    Julio César Álvaro-Villegas

    2011-11-01

    Full Text Available Background: chronic radiation proctopathy (CRP is associated with recurrent rectal bleeding and transfusional requirements. Argon plasma coagulation (APC and hyperbaric oxygen therapy (HOT have been shown to be effective in the control of CRP. No prospective comparisons have been reported between these treatments. Aim: the aim was to evaluate the effectiveness, safety and impact on tissue toxicity of APC compared to HOT in patients with CRP. Material and methods: a prospective study for evaluating treatment response was conducted. Patients with cervical cancer and CRP with rectal bleeding were recruited. They had not received previous treatment. Collected data included: demographics, previous radiation dosage, duration and severity of rectal bleeding. Hemoglobin, transfusional requirements, and tissue toxicity (SOMA LENT questionnaire at baseline and at 1, 2, and 3 months follow up were recorded. Results: thirty-one patients were included, 14 in the APC group and 17 in the HOT group. No response was noted in 13 and 18% of patients in the APC and HOT group respectively (p = NS. At the 1 and 2 months follow-up, the APC group showed a significantly better response in terms of transfusional requirements (0.6 vs. 3.4 and 0.7 vs. 2.5 and tissue toxicity score (5.3 vs. 8.6 and 3.8 vs. 7.248. After 3 months, both groups showed further improvement in all parameters without significant differences between them. Conclusions: APC and HOT were effective, safe and decreased the tissue toxicity scores in patients with CRP. However, response rate was higher and faster in the APC group.Introducción: la proctopatía por radiación (PPR se asocia con rectorragía recurrente y requerimientos de trasfusiones. La coagulación con argón plasma (APC y la terapia con oxígeno hiperbárico (HOT han sido efectivas en el control de la PPR. No hay estudios prospectivos comparativos entre ambas técnicas. Objetivo: el objetivo del estudio es evaluar la efectividad

  18. Hyperbaric oxygenation alleviates chronic constriction injury (CCI)-induced neuropathic pain and inhibits GABAergic neuron apoptosis in the spinal cord.

    Science.gov (United States)

    Fu, Huiqun; Li, Fenghua; Thomas, Sebastian; Yang, Zhongjin

    2017-09-15

    Dysfunction of GABAergic inhibitory controls contributes to the development of neuropathic pain. We examined our hypotheses that (1) chronic constriction injury (CCI)-induced neuropathic pain is associated with increased spinal GABAergic neuron apoptosis, and (2) hyperbaric oxygen therapy (HBO) alleviates CCI-induced neuropathic pain by inhibiting GABAergic neuron apoptosis. Male rats were randomized into 3 groups: CCI, CCI+HBO and the control group (SHAM). Mechanical allodynia was tested daily following CCI procedure. HBO rats were treated at 2.4 atmospheres absolute (ATA) for 60min once per day. The rats were euthanized and the spinal cord harvested on day 8 and 14 post-CCI. Detection of GABAergic cells and apoptosis was performed. The percentages of double positive stained cells (NeuN/GABA), cleaved caspase-3 or Cytochrome C in total GABAergic cells or in total NeuN positive cells were calculated. HBO significantly alleviated mechanical allodynia. CCI-induced neuropathic pain was associated with significantly increased spinal apoptotic GABA-positive neurons. HBO considerably decreased these spinal apoptotic cells. Cytochrome-C-positive neurons and cleaved caspase-3-positive neurons were also significantly higher in CCI rats. HBO significantly decreased these positive cells. Caspase-3 mRNA was also significantly higher in CCI rats. HBO reduced mRNA expression of caspase-3. CCI-induced neuropathic pain was associated with increased apoptotic GABAergic neurons induced by activation of key proteins of mitochondrial apoptotic pathways in the dorsal horn of the spinal cord. HBO alleviated CCI-induced neuropathic pain and reduced GABAergic neuron apoptosis. The beneficial effect of HBO may be via its inhibitory role in CCI-induced GABAergic neuron apoptosis by suppressing mitochondrial apoptotic pathways in the spinal cord. Increased apoptotic GABAergic neurons induced by activation of key proteins of mitochondrial apoptotic pathways in the dorsal horn of the spinal

  19. Hyperbaric intensive care technology and equipment.

    Science.gov (United States)

    Millar, Ian L

    2015-03-01

    In an emergency, life support can be provided during recompression or hyperbaric oxygen therapy using very basic equipment, provided the equipment is hyperbaric-compatible and the clinicians have appropriate experience. For hyperbaric critical care to be provided safely on a routine basis, however, a great deal of preparation and specific equipment is needed, and relatively few facilities have optimal capabilities at present. The type, size and location of the chamber are very influential factors. Although monoplace chamber critical care is possible, it involves special adaptations and inherent limitations that make it inappropriate for all but specifically experienced teams. A large, purpose-designed chamber co-located with an intensive care unit is ideal. Keeping the critically ill patient on their normal bed significantly improves quality of care where this is possible. The latest hyperbaric ventilators have resolved many of the issues normally associated with hyperbaric ventilation, but at significant cost. Multi-parameter monitoring is relatively simple with advanced portable monitors, or preferably installed units that are of the same type as used elsewhere in the hospital. Whilst end-tidal CO₂ readings are changed by pressure and require interpretation, most other parameters display normally. All normal infusions can be continued, with several examples of syringe drivers and infusion pumps shown to function essentially normally at pressure. Techniques exist for continuous suction drainage and most other aspects of standard critical care. At present, the most complex life support technologies such as haemofiltration, cardiac assist devices and extra-corporeal membrane oxygenation remain incompatible with the hyperbaric environment.

  20. 21 CFR 868.5470 - Hyperbaric chamber.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Hyperbaric chamber. 868.5470 Section 868.5470 Food... DEVICES ANESTHESIOLOGY DEVICES Therapeutic Devices § 868.5470 Hyperbaric chamber. (a) Identification. A hyperbaric chamber is a device that is intended to increase the environmental oxygen pressure to promote...

  1. Oxygen therapy - infants

    Science.gov (United States)

    ... may not work well and may die. Your baby may not grow properly. Many of the developing organs, including the brain and heart, may be injured. Too much oxygen can also cause injury. Breathing too much oxygen can damage the lung. ...

  2. Effects of hyperbaric oxygen therapy performed at different times on cognitive dysfunction of rats with traumatic brain injury%不同时间窗高压氧治疗对脑外伤大鼠认知功能障碍改善的实验研究

    Institute of Scientific and Technical Information of China (English)

    何俊德; 谢泽宇; 陈葆; 瞿文军

    2010-01-01

    目的 研究不同时间窗高压氧治疗对脑外伤大鼠认知功能障碍的治疗效果. 方法 将96只大鼠按随机数字表法分为正常对照组(A组)、液压冲击脑外伤模型组(B组)、液压冲击脑外伤模型+常规治疗组(C组)、液压冲击脑外伤模型+常规治疗+高压氧治疗组(D组),每组24只;D组在模型建立后根据高压氧治疗的时间点(3、12、24、72 h)分为4亚组(D-3 h组、D-12 h组、D-24 h组和D-72h组,每亚组6只).B、C、D组采用大鼠侧位液压冲击构建脑外伤模型后分别进行不同处理.应用水迷宫试验对比评价各组大鼠模型脑外伤后认知功能障碍的改变. 结果 在相同时间点寻找水下平台的潜伏期方面,B组最长,其次为C组、D组、A组,且D组中D.72 h组最长,其次为D-24 h组、D-12h组、D-3h组;在穿过原平台区域的次数方面,A组最多,其次为D组、C组、B组,且D组中D-3 h组最多,其次为D-12 h组、D-24 h组、D-72 h组,与B组比较差异均有统计学意义(p<0.05). 结论 高压氧治疗可以改善颅脑损伤大鼠的学习能力,对神经功能具有保护作用,且这种高压氧治疗的时间最好在损伤后12 h内完成,并且宜尽早实施.%Objective To investigate the effects of hyperbaric oxygen (HBO) therapy performed at different times on the cognitive dysfunction of rats with traumatic brain injury. Methods The traumatic brain injured models were established by use of lateral fluid percussion in rats. Ninety-six rats were equally randomized into 4 groups: control group (group A), traumatic brain injured model group (group B), traumatic brain injured model plus conventional therapy group (group C), traumatic brain injured model plus both conventional therapy and HBO therapy group (group D). And group D also divided into 4 subgroups (n=6): D-3 h group, D-12 h group, D-24 h group and D-72 h groups that HBO therapy was performed at 3, 12, 24 and 72 h of the traumatic brain injury, respectively. The

  3. Analysis on effect of hyperbaric oxygen combined with psychological nurs-ing intervention for patients with traumatic brain%颅脑损伤患者高压氧联合心理护理干预效果分析

    Institute of Scientific and Technical Information of China (English)

    杨艳; 张禹; 肖宏

    2015-01-01

    Objective To investigate the effect of hyperbaric oxygen combined with psychological nursing intervention for patients with traumatic brain. Methods From July to November 2014, 62 cases of the patients with traumatic brain injury in Beijing Navy General Hospital were randomly divided into observation group and control group, each group had 31 cases. Both groups were given hyperbaric oxygen treatment and hyperbaric oxygen routine care, based on these, the observation group was added to psychological care. Glasgow coma scale score (GCS) was used to assess the im-provement of patient's consciousness, barthel index (BI) was used to assess the prognosis of the patients, self-rating scale (SAS) and self-rating depression scale (SDS) was used to analyze patients' mental disorder, and patients satisfac-tion with care was evaluated. The results of the two groups were compared. Results①GCS score [(5.41±1.22) v s (5.49±1.24) points] of the observation group and control group two days before hyperbaric oxygen therapy was compared, there was no significant difference (t=1.24, P>0.05);GCS score [(7.78±1.56) vs (6.57±1.54)points] of the observation group and control group two weeks after hyperbaric oxygen therapy was compared, GCS score [(12.01±2.46) vs (8.31±1.93) points] of the observation group and control group eight weeks after hyperbaric oxygen therapy was compared, there were significant differences (t = 6.33, P0.05);高压氧治疗2周[(7.78±1.56)比(6.57±1.54)分]、8周[(12.01±2.46)比(8.31±1.93)分]比较,差异有统计学意义(t=6.33,P<0.05;t=12.41,P<0.01)。②两组患者治疗24周后,预后情况观察组优于对照组(字2=13.31,P<0.05)。③心理干预(高压氧治疗8周时)后,观察组焦虑评分[(44.38±2.47)分]低于对照组[(53.54±2.83)分],差异有统计学意义(t=5.20,P<0.05);观察组抑郁评分[(39.46±2.51)分]低于对照组[(47.62±2.16)分],差异有统计学意义(t=6.46,P<0.05)。榆观察组患者护理

  4. Commentary: Hyperbaric oxygen treatment for wounds - evidence and the Sword of Damocles.

    Science.gov (United States)

    Laden, Gerard

    2015-12-01

    Increased access to any treatment sensibly follows the clinical and cost benefit being established. For many treatments this requires multiple, high-quality clinical trials and supporting cost analysis. Cost analysis may be applied to a single treatment or used to compare two or more treatments. Clinical efficacy and cost benefit are best scrutinised and validated by publication in the peer-reviewed literature. True peer review is most effectively achieved 'after publication' by the wider scientific community, i.e., the journal readers. However, initially an editor, usually advised by referees, is asked to make a judgment on a paper's suitability for publication. It follows that medical journals are in a position of power and responsibility. Researchers and editors know publications are currency; effectively they are the equivalent of academic bitcoins. Regarding the paper in this issue by Santema et al., the same authors, in designing a prospective randomised controlled trial (RCT) of the role of hyperbaric oxygen treatment (HBOT) in diabetic wounds, included the name "Damocles" in that trial's title. Readers will perhaps appreciate from my comments below as a referee for the Santema et al. paper, that behind the scenes "the Sword of Damocles" (an allusion to the imminent and ever-present peril faced by those in positions of power) hangs over researchers, treating physician, journal editors and referees alike. Whilst positive about its content, upon reflection, my concern was the anticipated reception of this paper by the journal readership. This is, of course, a matter for the Editor; however, herewith is my reasoning. Further to the body of published work by Bennett et al., and others that has focused attention on the lack of good quality evidence for the use of HBOT for most indications, I think this regrettable state of affairs is now both known and accepted by mainstream healthcare purchasers and providers. I speculate that all these bodies already

  5. Repetitive long-term hyperbaric oxygen treatment (HBOT administered after experimental traumatic brain injury in rats induces significant remyelination and a recovery of sensorimotor function.

    Directory of Open Access Journals (Sweden)

    Klaus Kraitsy

    Full Text Available Cells in the central nervous system rely almost exclusively on aerobic metabolism. Oxygen deprivation, such as injury-associated ischemia, results in detrimental apoptotic and necrotic cell loss. There is evidence that repetitive hyperbaric oxygen therapy (HBOT improves outcomes in traumatic brain-injured patients. However, there are no experimental studies investigating the mechanism of repetitive long-term HBOT treatment-associated protective effects. We have therefore analysed the effect of long-term repetitive HBOT treatment on brain trauma-associated cerebral modulations using the lateral fluid percussion model for rats. Trauma-associated neurological impairment regressed significantly in the group of HBO-treated animals within three weeks post trauma. Evaluation of somatosensory-evoked potentials indicated a possible remyelination of neurons in the injured hemisphere following HBOT. This presumption was confirmed by a pronounced increase in myelin basic protein isoforms, PLP expression as well as an increase in myelin following three weeks of repetitive HBO treatment. Our results indicate that protective long-term HBOT effects following brain injury is mediated by a pronounced remyelination in the ipsilateral injured cortex as substantiated by the associated recovery of sensorimotor function.

  6. Retracted: Reversal of Spinal Cord Ischemia Following Endovascular Thoracic Aortic Aneurysm Repair with Hyperbaric Oxygen and Therapeutic Hypothermia.

    Science.gov (United States)

    Urquieta, Emmanuel; Jye Poi, Mun; Varon, Joseph; Lin, Peter H

    2015-12-14

    This article has been officially retracted. The senior author, Emmanuel Urquieta, of the article entitled, "Reversal of Spinal Cord Ischemia Following Endovascular Thoracic Aortic Aneurysm Repair with Hyperbaric Oxygen and Therapeutic Hypothermia," has requesed that the article, published online ahead of print (DOI: 10.1089/ther.2015.0025), be retracted because he discovered one of his coauthors mistakenly submitted the same article to the Journal of Vascular Surgery due to a miscommunication between them. The editorial leadership of Therapeutic Hypothermia and Temperature Management agree that the article must be retracted as a matter of proper scientific publishing protocol whereby an article may not be simultaneously submitted to two journals. The Editors commend Dr. Urquieta for willingly bringing this situation to their attention. Dr. Urquieta and his coauthors sincerely apologize to the Editors and the readership of Therapeutic Hypothermia and Temperature Management.

  7. Hyperbaric oxygen attenuates neuropathic pain and reverses inflammatory signaling likely via the Kindlin-1/Wnt-10a signaling pathway in the chronic pain injury model in rats.

    Science.gov (United States)

    Zhao, Baisong; Pan, Yongying; Xu, Haiping; Song, Xingrong

    2017-12-01

    Hyperbaric oxygen (HBO) therapy is proven to attenuate neuropathic pain in rodents. The goal of the present study was to determine the potential involvement of the Kindlin-1/Wnt-10a signaling pathway during astrocyte activation and inflammation in a rodent model of neuropathic pain. Rats were assigned into sham operation, chronic constriction injury (CCI), and CCI + HBO treatment groups. Neuropathic pain developed in rats following CCI of the sciatic nerve. Rats in the CCI + HBO group received HBO treatment for five consecutive days beginning on postoperative day 1. The mechanical withdrawal threshold (MWT) and the thermal withdrawal latency (TWL) tests were performed to determine mechanical and heat hypersensitivity of animals, respectively. Kindlin-1, Wnt-10a and β-catenin protein expression was examined by immunohistochemistry and Western blot analysis. Expression of tumor necrosis factor (TNF)-α was also determined by ELISA. Our findings demonstrated that HBO treatment significantly suppressed mechanical and thermal hypersensitivity in the CCI neuropathic pain model in rats. HBO therapy significantly reversed the up-regulation of Kindlin-1 in dorsal root ganglia (DRG), spinal cord, and hippocampus of CCI rats. CCI-induced astrocyte activation and increased levels of TNF-α were efficiently reversed by HBO (P neuropathic pain and inflammatory responses, possibly through regulation of the Kindlin-1/Wnt-10a signaling pathway.

  8. Hyperbaric Oxygen Treatment in Radiation-Induced Cystitis and Proctitis: A Prospective Cohort Study on Patient-Perceived Quality of Recovery

    Energy Technology Data Exchange (ETDEWEB)

    Oscarsson, Nicklas, E-mail: nicklas.oscarsson@vgregion.se [Department of Anaesthesiology and Intensive Care Medicine, Sahlgrenska Academy, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg (Sweden); Arnell, Per [Department of Anaesthesiology and Intensive Care Medicine, Sahlgrenska Academy, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg (Sweden); Lodding, Pär [Department of Urology, Sahlgrenska Academy, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg (Sweden); Ricksten, Sven-Erik; Seeman-Lodding, Heléne [Department of Anaesthesiology and Intensive Care Medicine, Sahlgrenska Academy, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg (Sweden)

    2013-11-15

    Purpose: In this prospective cohort study, the effects of hyperbaric oxygen treatment (HBOT) were evaluated concerning patient-perceived symptoms of late radiation-induced cystitis and proctitis secondary to radiation therapy for pelvic cancer. Methods and Materials: Thirty-nine patients, 35 men and 4 women with a mean age of 71 (range, 35-84) years were included after informed consent and institutional ethics approval. They had all been treated with radiation therapy for prostate (n=34), cervix (n=2), or rectal (n=3) cancer using external beam radiation at a dose of 25 to 75 Gy. Patients with hematuria requiring blood transfusion were excluded. The HBOT was delivered with 100% oxygen for 90 minutes at 2.0 to 2.4 atmospheres (ATA). Mean number of treatments was 36 (28-40). Symptoms were prospectively assessed using the Expanded Prostate Index Composite score before, during, and 6 to 12 months after HBOT. Results: The HBOT was successfully conducted, and symptoms were alleviated in 76% for patients with radiation cystitis, 89% for patients with radiation proctitis, and 88% of patients with combined cystitis and proctitis. Symptom reduction was demonstrated by an increased Expanded Prostate Index Composite score in the urinary domain from 50 ± 16 to 66 ± 20 after treatment (P<.001) and in the bowel domain from 48 ± 18 to 68 ± 18 after treatment (P<.001). For 31% of the patients with cystitis and 22% with proctitis, there were only trivial symptoms after HBOT. The improvement was sustained at follow-up in both domains 6 to 12 months after HBOT. No severe side effects were observed related to HBOT, and treatment compliance was high. Conclusions: HBOT can be an effective and safe treatment modality for late radiation therapy-induced soft tissue injuries in the pelvic region.

  9. Pressure-related effects of hyperbaric oxygen exposure on oxidation products and antioxidant enzymes in the rat lung

    Directory of Open Access Journals (Sweden)

    Bulent Uysal

    2011-02-01

    Full Text Available Objective: The aim of this study is to provide comprehensive information on the relationship between clinically used hyperbaric oxygen (HBO protocols and its oxidative effects. In order to enlighten this issue, we investigated the effects of various HBO pressure modalities on oxidant and antioxidant parameters in the rat lung. Methods: Sixty male Sprague-Dawley rats were divided into 6 groups. Group 1 was used as control. Groups 2 to 6 were subjected to 100% oxygen at a pressure of 1, 1.5, 2, 2.5, and 3 ATA (atmosphere absolute respectively for 2 hours. The lungs were taken immediately after exposure. Oxidation products of lipids (thiobarbituric acid reactive substances, TBARS and proteins (carbonyl formation, PCO, and antioxidant enzyme levels (superoxide dismutase, SOD; catalase, CAT, glutathione peroxidase, GSH-Px were determined. Results: TBARS, PCO, SOD and CAT levels increased concordantly with pressure. Significant change of TBARS levels started from 100% oxygen exposure at 1 ATA (normobaric, but PCO and CAT levels were affected first after 1.5, and SOD activity after 2 ATA. A significant correlation exists between exposure pressure and oxidative parameters. GSH-Px activity was not affected significantly. Conclusion: The oxidative effect of HBO in rat lung presents a positive correlation with increasing exposure pressure. [J Exp Integr Med 2011; 1(1: 37-42

  10. Therapeutic effect of hyperbaric oxygen in psoriasis vulgaris: two case reports and a review of the literature

    Directory of Open Access Journals (Sweden)

    Butler Glenn

    2009-08-01

    Full Text Available Abstract Introduction Psoriasis is an inflammatory and immunological cutaneous disease. The high morbidity in patients with psoriasis results from severe clinical manifestations and/or adverse effects of treatment. The Undersea and Hyperbaric Medical Society and Federal Medicare and Medicaid Services have approved the use of hyperbaric oxygen (HBO2 for more than 15 indications, including wound healing, infections and late effects of radiation, which are largely unresponsive to conventional treatments. Accumulated data show that HBO2 has anti-inflammatory effects and other positive influences on the immune system, making it a rational treatment in the management of psoriasis plaques and arthritis. Case presentation We present the cases of two patients with long histories of psoriasis vulgarus who exhibited marked improvement with use of HBO2. The first patient was 40 years old and had pustular psoriasis and psoriatic arthritis. He was treated with six sessions of HBO2 (at 2.8 atmospheres of pressure for 60 minutes, which successfully controlled his symptoms. At the 18-month post-treatment follow up, the patient exhibited complete remission of psoriasis and marked improvement in psoriatic arthritis without medication. The second patient was 55 years old with extensive psoriatic lesions, and exhibited marked improvement within 15 sessions of HBO2. No adverse effects of HBO2 were identified. Conclusions HBO2 may possess potential therapeutic efficacy in the management of psoriasis. We outline the pathogenesis of psoriasis and the selective anti-inflammatory and immunosuppressive effects of HBO2. We hope that this will provide a basis for elucidating the mechanisms of action and consequently pave the way for further controlled studies.

  11. Medical devices and procedures in the hyperbaric chamber.

    Science.gov (United States)

    Kot, Jacek

    2014-12-01

    The aim of this paper is to present current controversies concerning the safety of medical devices and procedures under pressure in a hyperbaric chamber including: defibrillation in a multiplace chamber; implantable devices during hyperbaric oxygen treatment (HBOT) and the results of a recent European questionnaire on medical devices used inside hyperbaric chambers. Early electrical defibrillation is the only effective therapy for cardiac arrest caused by ventricular fibrillation or pulseless ventricular tachycardia. The procedure of defibrillation under hyperbaric conditions is inherently dangerous owing to the risk of fire, but it can be conducted safely if certain precautions are taken. Recently, new defibrillators have been introduced for hyperbaric medicine, which makes the procedure easier technically, but it must be noted that sparks and fire have been observed during defibrillation, even under normobaric conditions. Therefore, delivery of defibrillation shock in a hyperbaric environment must still be perceived as a hazardous procedure. Implantable devices are being seen with increasing frequency in patients referred for HBOT. These devices create a risk of malfunction when exposed to hyperbaric conditions. Some manufacturers support patients and medical practitioners with information on how their devices behave under increased pressure, but in some cases an individual risk-benefit analysis should be conducted on the patient and the specific implanted device, taking into consideration the patient's clinical condition, the indication for HBOT and the capability of the HBOT facility for monitoring and intervention in the chamber. The results of the recent survey on use of medical devices inside European hyperbaric chambers are also presented. A wide range of non-CE-certified equipment is used in European chambers.

  12. Oxygen treatment of cluster headache

    DEFF Research Database (Denmark)

    Petersen, Anja S; Barloese, Mads C J; Jensen, Rigmor H

    2014-01-01

    of oxygen treatment. One study is observational and the remaining five are RCTs. Another five studies were on hyperbaric oxygen treatment hereof two case studies. CONCLUSION: Oxygen therapy can be administered at different flow rates. Three studies investigate the effect of low-flow oxygen, 6-7 l....../min, and found a positive response in 56%, 75% and 82%, respectively, of the patients. One study investigates high-flow oxygen, 12 l/min, and found efficacy in 78% of attacks. The effect of hyperbaric oxygen therapy has been investigated in a few small studies and there is evidence only for an acute...

  13. Effectiveness of hyperbaric oxygen for experimental treatment of schistosomiasis mansoni using praziquantel-free and encapsulated into liposomes: assay in adult worms and oviposition.

    Science.gov (United States)

    Frezza, Tarsila Ferraz; de Souza, Ana Luiza Ribeiro; Prado, César Corat Ribeiro; de Oliveira, Claudineide Nascimento Fernandes; Gremião, Maria Palmira Daflon; Giorgio, Selma; Dolder, Mary Anne Heidi; Joazeiro, Paulo Pinto; Allegretti, Silmara Marques

    2015-10-01

    The treatment of schistosomiasis depends on a single drug: praziquantel (PZQ). However, this treatment presents limitations such as low and/or erratic bioavailability that can contribute to cases of tolerance. Improvements to the available drug are urgently needed and studies with a controlled system of drug release, like liposomes, have been gaining prominence. The present study evaluated the activity and synergy between liposomal-praziquantel (lip.PZQ) and hyperbaric oxygen therapy (HBO). Mice received doses of 60 or 100mg/kg PZQ or lip.PZQ, 50 days post-infection, and after the treatment, were exposed to HBO (3 atmosphere absolute - ATA) for 1h. The viability of adult worms and oviposition were analyzed, by necropsy and Kato-Katz examination performed after 15 days of treatment. A concentration of 100mg/kg of lip.PZQ+HBO was more effective (48.0% reduction of worms, 83.3% reduction of eggs/gram of feces) and 100% of the mice had altered of oograms (indicating interruption of oviposition) compared to other treatments and to the Control group (infected and untreated). It is known that PZQ requires participation of the host immune system to complete its antischistosomal activity and that HBO is able to stimulate the immune system. The drug became more available in the body when incorporated into liposomes and, used with HBO, the HBO worked as an adjuvant. This explains the decreases of oviposition and worms recovered form hepatic portal system.

  14. Oxygen therapy reduces postoperative tachycardia

    DEFF Research Database (Denmark)

    Stausholm, K; Kehlet, H; Rosenberg, J

    1995-01-01

    Concomitant hypoxaemia and tachycardia in the postoperative period is unfavourable for the myocardium. Since hypoxaemia per se may be involved in the pathogenesis of postoperative tachycardia, we have studied the effect of oxygen therapy on tachycardia in 12 patients randomly allocated to blinded...

  15. Effects of hyperbaric oxygen combined with reinhartdt and sea cumber capsule therapy on abilities of learning and memory in vascular dementia rats%高压氧联合复方海蛇胶囊对血管性痴呆大鼠学习记忆能力行为学的影响

    Institute of Scientific and Technical Information of China (English)

    朱燕平; 寇雪莲; 何松彬; 唐维国

    2013-01-01

    Objective:To investigate the effect's of hyperbaric oxygen(HBO) combined with reinhartdt and sea cumber capsule (RSC) therapy on abilities of learning and memory in vascular dementia rats.Method: In forty Sprague-Dawly rats weighted 250—300g, the reperfusion middle cerebral artery occlusion (rM-CAO) models were established with thread embolism method. These model rats were divided into five groups: sham-operated(SHAM) group, MCAO mode(MCAO), HBO treatment(HBO) group, reinhartdt and sea cumber capsule treatment(RSC) group and HBO combined with RSC treatment(HBO + RSC) group, 8 rats in each group. At the end of 4 week treatment with HBO and/or RSC, the abilities of learning and memory of rats were assessed with Morris water maze. Result: ①In Morris water maze test, the average escape latencies in HBO group(41.15 ± 6.75s),RSC group(44.11± 6.05s) and HBO+RSC group(29.32 ± 3.72s) were significantly shorter than that in MCAO group(67.05 ± 9.00s) (P0.05). ② The average swimming path lengths in HBO group(7631.89 ± 1277.73mm),RSC group(8114.48 ± 1091.82mm)anrl HBO+RSC group (5699.27 ± 1339.82mm) were significantly shorter than that in MCAO group(12492.46 ± 2161.74mm) (P0.05). ③The striding platform times in HBO group(2.74 ± 0.65 times),RSC group(2.25 ± 0.87 times) and HBO+ RSC(3.82 ± 0.96 times) were significantly longer than that in MCAO group(1.06 ± 0.55 times) (P0.05).④The platform detention time in HBO group (30.05 ± 3.58s),RSC group(30.24± 5.13s) and HBO + RSC group(35.29 ± 3.51s) increased significantly than that in MCAO group (24.52 ± 4.05s)(P<0.05); the platform detention time in HBO+RSC group increased significantly than that in HBO group or RSC group(P<0.05); no significant difference was found between RSC group and HBO group. Conclusion: HBO and/or RSC therapy could improve learning and memory abilities in vascular dementia rats effectively. The effect of HBO combined with RSC therapy in vascular dementia rats was much better than either

  16. Effects of repeated hyperbaric nitrogen-oxygen exposures on the striatal dopamine release and on motor disturbances in rats.

    Science.gov (United States)

    Lavoute, Cécile; Weiss, Michel; Rostain, Jean-Claude

    2005-09-14

    Previous studies have demonstrated disruptions of motor activities and a decrease of extracellular dopamine level in the striatum of rats exposed to high pressure of nitrogen. Men exposed to nitrogen pressure develop also motor and cognitive disturbances related to inert gas narcosis. After repetitive exposures, adaptation to narcosis was subjectively reported. To study the effects of repetitive exposures to hyperbaric nitrogen-oxygen, male Sprague-Dawley rats were implanted in the striatum with multifiber carbon dopamine-sensitive electrodes. After recovery from surgery, free-moving rats were exposed for 2 h up to 3 MPa of nitrogen-oxygen mixture before and after one daily exposure to 1 MPa of nitrogen-oxygen, for 5 consecutive days. Dopamine release was measured by differential pulse voltammetry and motor activities were quantified using piezo-electric captor. At the first exposure to 3 MPa, the striatal dopamine level decreased during the compression (-15%) to reach -20% during the stay at 3 MPa. Motor activities were increased during compression (+15%) and the first 60 min at constant pressure (+10%). In contrast, at the second exposure to 3 MPa, an increase of dopamine of +15% was obtained during the whole exposure. However, total motor activities remained unchanged as compared to the first exposure. Our results confirm that nitrogen exposure at 3 MPa led to a decreased striatal dopamine release and increased motor disturbances in naïve rats. Repetitive exposures to 1 MPa of nitrogen induced a reversal effect on the dopamine release which suggests a neurochemical change at the level of the neurotransmitter regulation processes of the basal ganglia. In contrast, motor activity remained quantitatively unchanged, thus suggesting that dopamine is not involved alone in modulating these motor disturbances.

  17. Early outcome and blood-brain barrier integrity after co-administered thrombolysis and hyperbaric oxygenation in experimental stroke

    Directory of Open Access Journals (Sweden)

    Michalski Dominik

    2011-06-01

    Full Text Available Abstract Background After promising results in experimental stroke, normobaric (NBO or hyperbaric oxygenation (HBO have recently been discussed as co-medication with tissue plasminogen activator (tPA for improving outcome. This study assessed the interactions of hyperoxia and tPA, focusing on survival, early functional outcome and blood-brain barrier (BBB integrity following experimental stroke. Methods Rats (n = 109 underwent embolic middle cerebral artery occlusion or sham surgery. Animals were assigned to: Control, NBO (60-minute pure oxygen, HBO (60-minute pure oxygen at 2.4 absolute atmospheres, tPA, or HBO+tPA. Functional impairment was assessed at 4 and 24 hours using Menzies score, followed by intravenous application of FITC-albumin as a BBB permeability marker, which was allowed to circulate for 1 hour. Further, blood sampling was performed at 5 and 25 hours for MMP-2, MMP-9, TIMP-1 and TIMP-2 concentration. Results Mortality rates did not differ significantly between groups, whereas functional improvement was found for NBO, tPA and HBO+tPA. NBO and HBO tended to stabilize BBB and to reduce MMP-2. tPA tended to increase BBB permeability with corresponding MMP and TIMP elevation. Co-administered HBO failed to attenuate these early deleterious effects, independent of functional improvement. Conclusions The long-term consequences of simultaneously applied tPA and both NBO and HBO need to be addressed by further studies to identify therapeutic potencies in acute stroke, and to avoid unfavorable courses following combined treatment.

  18. 依帕司他联合高压氧治疗早期糖尿病肾病的临床观察%Clinical observation on early diabetic nephropathy treated with epalrestat combined hyperbaric oxygen

    Institute of Scientific and Technical Information of China (English)

    黄锦欢; 孙鹏飞; 覃灿彬; 赖海春; 张俊林

    2012-01-01

    Objective To observe the effects of combined therapy of epalrestat and hyperbaric oxygen on urinary albumin excretion rate of early diabetic nephropathy. Methods 78 patients with early type 2 diabetic nephropathy were randomly divided into treated group and control group (39 cases each). Control group was treated with insulin and epalrestat, and treated group was treated with insulin, epalrestat and hyperbaric oxygen. The course last 2 months. Blood glucose, lipids, blood rheology and urinary albumin excretion rate ( UAER) were detected before and after treatment. Results There were no differences between 2 groups in blood glucose and lipid before or after treatment (P >0. 05 ). UAER was decreased in both groups as compared to before treatment. But there was significantly difference between 2 groups in UAER after treatment (P<0. 05). Conclusion The combined therapy of epalrestat and hyperbaric oxygen reduces UAER, thus inhibiting the progress of early diabetic kidney disease, the therapy is more effective than epalrestat alone.%目的 观察依帕司他联合高压氧治疗对早期糖尿病肾病尿白蛋白排泄率的影响.方法 将78例早期2型糖尿病肾病患者随机分为治疗组和对照组(各39例),两组均予胰岛素控制血糖,并予依帕司他口服,在此基础上,治疗组加予高压氧治疗,疗程2个月,治疗前后检测血糖、血脂、血液流变学及尿白蛋白排泄率(UAER).结果 治疗前后两组患者血糖、血脂等比较,差异无统计学意义(P>0.05);治疗后两组UAER均下降,但治疗组下降更加显著,两组比较差异有统计学意义(P<0.05).结论 依帕司他联合高压氧可有效降低尿白蛋白排泄率,从而抑制早期糖尿病肾病的进展,疗效优于单纯药物治疗.

  19. Effect of hyperbaric oxygen on cytochrome C, Bcl-2 and bax expression after experimental traumatic brain injury in rats

    Institute of Scientific and Technical Information of China (English)

    LIU Zhan; JIAO Qing-fang; YOU Chao; CHE Yan-jun; SU Fang-zhong

    2006-01-01

    Objective: To explore the effects of hyperbaric oxygen (HBO) treatment on the neuronal apoptosis at an earlier stage and the expressions of Cytochrome C (Cyt C), Bcl-2 (B-cell lymphoma-2 family) and Bax (Bcl-2associated X protein) in rat brain tissues after traumatic brain injury (TBI).Methods: Forty adult rats were divided into two groups, i.e., Group A ( the rats with untreated TBI) and Group B ( rats with HBO treatment after TBI). Sections of brain tissues of these two groups were then detected at 3,6,12,24,72 hours after TBI by immunohistochemistry and electronmicroscope, respectively.Results: HBO treatment could up-regulate the expression of Bcl-2 within 72 hours, reduce the release of Cyt C from mitochondria, attenuate the formation of dimeric Bax and alleviate the mitochondrial edema within 24 hours after TBI.Conclusions: HBO treatment can alleviate neuronal apoptosis after TBI by reducing the release of Cyt C and the dimers of Bax and up-regulating the expression of Bcl-2.

  20. Hyperbaric oxygen for the treatment of the rare combination of central retinal vein occlusion and cilioretinal artery occlusion.

    Science.gov (United States)

    Celebi, Ali Riza Cenk; Kilavuzoglu, Ayse Ebru; Altiparmak, Ugur Emrah; Cosar, C Banu; Ozkiris, Abdullah

    2016-03-01

    A 43-year-old male presented with sudden onset of painless, blurred vision in his left eye. Dilated fundoscopic examination showed signs consistent with the diagnosis of a combination of central retinal vein occlusion (CRVO) and cilioretinal artery occlusion (CLRAO). He received daily 2-h sessions of hyperbaric oxygen treatment (HBOT), 253 kPa for 14 days. At the end of the HBOT course, the patient's left visual acuity had improved from 20/200 to 20/20. Dilated fundoscopic examination showed that the intra-retinal haemorrhages in the entire retina and the retinal whitening along the course of the CLRA seen at presentation had completely resolved. The combination of CLRAO and CRVO comprises a discrete clinical entity. Even though there are many hypotheses concerning this condition, it is most likely the result of elevated intraluminal pressure in the retinal capillaries due to CRVO that exceeds the pressure in the CLRA. HBOT may be an effective treatment for CRVO-associated CLRAO.

  1. Effect Analysis of Hyperbaric Oxygen Auxiliary Drug in the Treatment of Sudden Deafness%高压氧辅助药物治疗突发性耳聋效果探析

    Institute of Scientific and Technical Information of China (English)

    高文华

    2014-01-01

    Objective:To investigate the clinical effect and significance of hyperbaric oxygen therapy for sudden deafness.Method:56 patients with sudden deafness in our hospital form January 2008 to December 2010 as the object of observation,according to different clinical diagnosis and treatment measures for the observation group(combined with hyperbaric oxygen treatment group)and the control group(simple drug treatment group),28 cases in each group,after 4 weeks,compared two groups of clinical curative effect.Result:After 4 weeks,the clinical cure rate of the observation group was 85.71%,better than the control group in improving symptoms,two groups had significant difference(P<0.05).Conclusion:Adjunctive hyperbaric oxygen therapy can actively improve the microcirculation in patients with hearing impairment and symptoms of sudden deafness,improve the clinical cure rate,worthy of clinical application.%目的:探讨高压氧辅助药物治疗突发性耳聋的临床效果及意义。方法:选取2010年1月-2012年12月本院临床收治的突发性耳聋患者56例为观察对象,依据临床诊治措施的不同分为观察组(联用高压氧治疗组)和对照组(单纯药物治疗组)各28例,4周后比较两组临床治疗效果。结果:治疗4周后,观察组临床治愈率为85.71%,在症状改善方面优于对照组,两组比较差异具有统计学意义(P<0.05)。结论:高压氧辅助药物治疗突发性耳聋能积极改善微循环和患者听力减退症状,提高临床治愈率,值得临床应用。

  2. Hyperbaric oxygen preconditioning induces tolerance against oxidative injury and oxygen-glucose deprivation by up-regulating heat shock protein 32 in rat spinal neurons.

    Directory of Open Access Journals (Sweden)

    Guoyang Huang

    Full Text Available OBJECTIVE: Hyperbaric oxygen (HBO preconditioning (HBO-PC has been testified to have protective effects on spinal cord injury (SCI. However, the mechanisms remain enigmatic. The present study aimed to explore the effects of HBO-PC on primary rat spinal neurons against oxidative injury and oxygen-glucose deprivation (OGD and the relationship with heat shock proteins (HSPs. METHODS: Primary rat spinal neurons after 7 days of culture were used in this study. HSPs were detected in rat spinal neurons following a single exposure to HBO at different time points by Western blot. Using lactate dehydrogenase release assay and cell counting kit-8 assay, the injuries induced by hydrogen peroxide (H2O2 insult or OGD were determined and compared among neurons treated with HBO-PC with or without HSP inhibitors. RESULTS: The results of Western blot showed that HSP27, HSP70 and HSP90 have a slight but not significant increase in primary neurons following HBO exposure. However, HSP32 expression significantly increased and reached highest at 12 h following HBO exposure. HBO-PC significantly increased the cell viability and decreased the medium lactate dehydrogenase content in cultures treated with H2O2 or OGD. Pretreatment with zinc protoporphyrin IX, a specific inhibitor of HSP32, significantly blocked the protective effects of HBO-PC. CONCLUSIONS: These results suggest that HBO-PC could protect rat spinal neurons in vitro against oxidative injury and OGD mostly by up-regulating of HSP32 expression.

  3. Development of underwater and hyperbaric medicine in Malaysia.

    Science.gov (United States)

    Rozali, A; Rampal, K G; Zin, B Mohd; Sherina, M S; Khairuddin, H; Abd Halim, M; Sulaiman, A

    2006-12-01

    Underwater and Hyperbaric Medicine is a treatment modality gaining recognition in Malaysia. It uses the hyperbaric oxygen therapy (HBOT) approach where patients are placed in recompression chambers and subjected to oxygen therapy under pressure. In Malaysia it was introduced as early as the 1960's by the Royal Malaysian Navy to treat their divers for decompression illness (DCI), arterial gas embolism (AGE) and barotraumas. Other sectors in the armed forces, universities and private health centres began developing this approach too in the late 1990's, for similar purposes. In 1996, Underwater and Hyperbaric Medicine began gaining its popularity when the Institute of Underwater and Hyperbaric Medicine at the Armed Forces Hospital in Lumut started treating specific clinical diseases such as diabetic foot ulcers, osteomyelitis, and carbon monoxide poisoning and other diseases using HBOT. This paper discusses the development of this interesting treatment modality, giving a brief historical overview to its current development, as well as provides some thought for its future development in Malaysia.

  4. The bactericidal effect of 470-nm light and hyperbaric oxygen on methicillin-resistant Staphylococcus aureus (MRSA).

    Science.gov (United States)

    Bumah, Violet Vakunseh; Whelan, Harry Thomas; Masson-Meyers, Daniela Santos; Quirk, Brendan; Buchmann, Ellen; Enwemeka, Chukuka Samuel

    2015-04-01

    It has been shown that, in vitro, hyperbaric oxygen (HBO) suppresses 28 % bacterial growth, while 470-nm blue light alone suppresses up to 92 % methicillin-resistant Staphylococcus aureus (MRSA) in one application in vitro. Therefore, we determined if combined 470-nm light (55 J/cm(2)) and HBO will yield 100 % bacterial suppression in experimental simulation of mild, moderate or severe MRSA infection. We cultured MRSA at 3 × 10(6), 5 × 10(6), 7 × 10(6), 8 × 10(6), or 12 × 10(6) CFU/ml and treated each concentration in four groups as follows: (1) control (no treatment) (2) photo-irradiation only, (3) photo-irradiation then HBO, (4) HBO only, and (5) HBO then photo-irradiation. Bacteria colonies were then quantified. The results showed that at each bacterial concentration, HBO alone was significantly less effective in suppressing MRSA than photo-irradiation or combined HBO and photo-irradiation (p  0.05), neither did HBO treatment either before or after irradiation make a difference. Furthermore, at no bacterial concentration was 100 % MRSA suppression achieved. Indeed, the maximum bacterial suppression attained was in the mild infection model (3 × 10(6) CFU/ml), with blue light producing 97.3 ± 0.2 % suppression and HBO + 55 J/cm(2) yielding 97.5 ± 2.5 % suppression. We conclude that (1) HBO and 470-nm light individually suppress MRSA growth; (2) 470-nm blue light is more effective in suppressing MRSA than HBO; and (3) HBO did not act synergistically to heighten the bactericidal effect of 470-nm light.

  5. The bactericidal effect of 470 nm light and hyperbaric oxygen on methicillin-resistant Staphylococcus aureus (MRSA)

    Science.gov (United States)

    Bumah, Violet Vakunseh; Whelan, Harry Thomas; Masson-Meyers, Daniela Santos; Quirk, Brendan; Buchmann, Ellen; Enwemeka, Chukuka Samuel

    2015-01-01

    It has been shown that, in vitro, hyperbaric oxygen (HBO) suppresses 28% bacterial growth, while 470 nm blue light alone suppresses up to 92% methicillin resistant Staphylococcus aureus (MRSA) in one application in vitro. Therefore, we determined if combined 470 nm light (55 J/cm2) and HBO will yield 100% bacterial suppression in experimental simulation of mild, moderate or severe MRSA infection. We cultured MRSA at 3×106, 5×106, 7×106, 8×106 or 12×106 CFU/ml and treated each concentration in four groups as follows: (1) Control (no treatment) (2) photo-irradiation only, (3) photo-irradiation then HBO, (4) HBO only, and (5) HBO then photo-irradiation. Bacteria colonies were then quantified. The results showed that at each bacterial concentration, HBO alone was significantly less effective in suppressing MRSA than photo-irradiation or combined HBO and photo-irradiation (p 0.05), neither did HBO treatment either before or after irradiation make a difference. Furthermore, at no bacterial concentration was 100% MRSA suppression achieved. Indeed, the maximum bacterial suppression attained was in the mild infection model (3×106 CFU/ml), with blue light producing 97.3±0.2% suppression and HBO +55 J/cm2 yielding 97.5±2.5% suppression. We conclude that: (1) HBO and 470 nm light individually suppress MRSA growth; (2) 470nm blue light is more effective in suppressing MRSA than HBO; and (3) HBO did not act synergistically to heighten the bactericidal effect of 470 nm light. PMID:25700768

  6. Hyperbaric Oxygen Prevents Cognitive Impairments in Mice Induced by D-Galactose by Improving Cholinergic and Anti-apoptotic Functions.

    Science.gov (United States)

    Chen, Chunxia; Huang, Luying; Nong, Zhihuan; Li, Yaoxuan; Chen, Wan; Huang, Jianping; Pan, Xiaorong; Wu, Guangwei; Lin, Yingzhong

    2017-01-11

    Our previous study demonstrated that hyperbaric oxygen (HBO) improved cognitive impairments mainly by regulating oxidative stress, inflammatory responses and aging-related gene expression. However, a method for preventing cognitive dysfunction has yet to be developed. In the present study, we explored the protective effects of HBO on the cholinergic system and apoptosis in D-galactose (D-gal)-treated mice. A model of aging was established via systemic intraperitoneal injection of D-gal daily for 8 weeks. HBO was administered during the last 2 weeks of D-gal injection. Our results showed that HBO in D-gal-treated mice significantly improved behavioral performance on the open field test and passive avoidance task. Studies on the potential mechanisms of this effect showed that HBO significantly reduced oxidative stress and blocked the nuclear factor-κB pathway. Moreover, HBO significantly increased the levels of choline acetyltransferase and acetylcholine and decreased the activity of acetylcholinesterase in the hippocampus. Furthermore, HBO markedly increased expression of the anti-apoptosis protein Bcl-2 and glial fibrillary acidic protein meanwhile decreased expression of the pro-apoptosis proteins Bax and caspase-3. Importantly, there was a significant reduction in expression of Aβ-related genes, such as amyloid precursor protein, β-site amyloid cleaving enzyme-1 and cathepsin B mRNA. These decreases were accompanied by significant increases in expression of neprilysin and insulin-degrading enzyme mRNA. Moreover, compared with the Vitamin E group, HBO combined with Vitamin E exhibited significant difference in part of the above mention parameters. These findings suggest that HBO may act as a neuroprotective agent in preventing cognitive impairments.

  7. Effect of hyperbaric oxygen combined withα-lipoic acid on neurological function and serum indexes of patients with diabetic peripheral neuropathy

    Institute of Scientific and Technical Information of China (English)

    Yu Li; Ling Qi; Jun Li

    2016-01-01

    Objective:To analyze the effect of hyperbaric oxygen combined withα-lipoic acid on neurological function and serum indexes of patients with diabetic peripheral neuropathy. Methods:A total of 118 diabetic peripheral neuropathy patients who received treatment in our hospital were selected as research subjects, and according to the different clinical treatment they received, all included patients were divided into observation group 59 cases and control group 59 cases. Control group received conventional clinical treatment, and observation group received additional hyperbaric oxygen combined withα-lipoic acid treatment. Differences in nerve conduction velocity, gastrocnemius nerve threshold, illness-related factors, oxidative stress indicator values, and so on were compared between two groups after treatment.Results:MCV and SCV values of median nerve, ulnar nerve and tibial nerve of observation group after treatment were higher than those of control group (P<0.05); gastrocnemius nerve threshold of observation group after treatment were significantly lower than those of control group (P<0.05); serum CP and BDNF values of observation group after treatment were higher than those of control group while Cys-C, SDF-1α, HMGB1 and MBP values were lower than those of control group (P<0.05); serum MDA and NO values of observation group after treatment were lower than those of control group while SOD, CAT and GSH-Px values were higher than those of control group (P<0.05).Conclusions:Hyperbaric oxygen combined withα-lipoic acid is a good method to optimize the neurological function and improve overall illness of patients with diabetic peripheral neuropathy, and is expected to become a new way of inhibiting disease progression and improving disease outcome.

  8. 高压氧舱预防性维护与质量管理%Practice of hyperbaric oxygen chamber preventive maintenance and service based on quality management

    Institute of Scientific and Technical Information of China (English)

    鲁永杰; 何彩红; 王金菊

    2014-01-01

    目的:高压氧舱使用的广泛性与高风险意味着在使用时必须做好质量管理工作,以确保其安全稳定运行。方法:结合质量管理与临床使用的要求,对高压氧舱进行定期检测,制定预防性维护和保养计划,做好气路、控制系统和操作部分的预防性维护保养。结果:医学工程技术人员和临床使用人员相互配合,从定期检测、人员管理和预防性维护保养三个方面确保高压氧舱安全使用。结论:制定相关制度和应急预案,严格管理,加强医护人员的操作和使用培训,从而保障高压氧舱的临床使用安全。%Objective:It is important to make sure hyperbaric oxygen chamber safe and stable for its generalized and high risk.Methods: The gas path, control system and operation of hyperbaric oxygen chamber should be maintained timing based on quality management and clinical using requirement.Results: Medical engineering technicians and clinical use of personnel to cooperate with each other, from the regular inspection, personnel management and preventive maintenance to make sure the safety use of hyperbaric oxygen chamber.Conclusion: Making relative system and emergence plan, strengthening train to users and strict management can make its used safe.

  9. 高压氧治疗儿童病毒性脑炎的效果分析%The curative effects of hyperbaric oxygen on treating children with viral meningitis

    Institute of Scientific and Technical Information of China (English)

    曾彦; 罗一峰

    2014-01-01

    Objective To investigate the curative effects of hyperbaric oxygen on treating children with viral meningitis.Methods 92 children with viral meningitis from October 2012 to October 2013 in our hospital were randomly divided into the observation group (n=46) and the control group (n=46). The control group was treated with conventional basic treatment measures ,and the observation group was treated with conventional treatment combined with hyperbaric oxygen measures. Re-sults The aphasia improve time ,facial paralysis improve time ,limb paralysis improve time and total treatment efficiency of ob-servation group were better than these of control group. Conclusion Hyperbaric oxygen therapy has a better curative effect on treating children with viral meningitis ,which is worthy of clinic application.%目的:探讨高压氧治疗儿童病毒性脑炎的临床疗效,为临床相关研究提供借鉴和参考。方法儿童病毒性脑炎患者92例随机将患儿分为对照组和观察组各46例。对照组采用常规基础治疗,观察组加用高压氧治疗。结果(1)2组失语改善时间、面瘫改善时间、肢瘫改善时间比较,观察组均显著优于对照组,差异有计学意义(P均<0.05);(2)观察组总有效率显著高于对照组,差异有统计学意义(χ2=6.4519,P=0.0111)。结论与常规治疗方法比较,高压氧治疗儿童病毒性脑炎患儿疗效显著,是临床治疗儿童病毒性脑炎的理想选择。

  10. 高压氧治疗各期糖尿病足间歇性跛行的疗效观察%Hyperbaric Oxygen Treatment of Diabetic Foot Every Period Curative Effect Observation of Intermittent Claudication

    Institute of Scientific and Technical Information of China (English)

    于桂贤

    2015-01-01

    Objective To observe patients with hyperbaric oxygen treatment of diabetic foot every period of intermittent claudication.Methods Select 26 patients with diabetic foot, no burst but plantar skin dark purple 0 grade diabetic foot 7 cases, the foot has burst 19 cases, observation on foot pain. ResultsAfter hyperbaric oxygen therapy group, on foot pain signiifcantly prolong time data to compare the two groups have statistical signiifcance (P< 0.05). Ankle brachial index (ABI) and local skin temperature is improved. Blood glucose significantly lower after treatment. Ulcer healing in 11 cases, remaining signiifcant reduction, 8 cases of ulcer surface can avoid amputation. Resting at night sex signiifcantly reduce pain, show the sleep quality improved.Conclusion Hyperbaric oxygen treatment of diabetic foot every period all can obtain satisfactory curative effect.%目的:观测高压氧治疗各期糖尿病足患者间歇性跛行的疗效。方法选取糖尿病足患者26例,无破溃但足趾皮肤暗紫色的0级糖尿病足7例,足部破溃19例,观察步行引起疼痛的时间。结果经过高压氧治疗组,步行引起疼痛的时间明显延长,两组数据比较有统计学意义,P<0.05。踝肱指数(ABI)及局部皮温有所改善。治疗后血糖下降明显。溃疡面愈合11例,剩余8例溃疡面明显缩小,可以避免截肢。夜间静息性疼痛明显减轻,表现为睡眠质量改善。结论高压氧治疗各期糖尿病足均可获得满意疗效。

  11. 高压氧对大鼠T淋巴细胞和细胞因子的影响%Effect of hyperbaric oxygen on T-lymphoid cells and cytokines in rats

    Institute of Scientific and Technical Information of China (English)

    刘志红; 冯芳; 王钢

    2012-01-01

    目的 研究高压氧对健康大鼠以及全身炎症反应综合征(SIRS)大鼠T淋巴细胞和细胞因子(IL-6、IL-10、TNF-α)等的影响.方法 40只雄性SD大鼠随机(随机数字法)分为5组.A组:腹腔注射生理盐水(0.9% NaCl,5 m1/kg)作为对照组;B组:腹腔注射等量生理盐水,做3次高压氧治疗;C组:腹腔注射酵母多糖-石蜡悬液(500 mg/kg);D组:腹腔注射等量酵母多糖-石蜡悬液,做1次高压氧治疗;E组:腹腔注射等量酵母多糖-石蜡悬液,做3次高压氧治疗.所有大鼠均于腹腔注射24h后处死,门静脉取血,标本采用流式细胞技术对CD3+ CD4+CD8+进行计数,应用ELISA方法检测IL-6、IL-10、TNF-α血浆水平,以单因素方差分析及LSD-t检验分析数据.结果 高压氧治疗可显著降低健康大鼠外周血CD4 T细胞百分比(P<0.01),使CD4/CD8T细胞比值下降(P<0.05).酵母多糖腹腔注射使大鼠外周血CD4、CD8 T细胞均减少(P<0.01).1次和3次HBO治疗可使酵母多糖所致CD4 T细胞减少明显恢复(P<0.01,P<0.05).对于未出现高炎症反应的大鼠,HBO治疗可增加IL-6 (P <0.05)和TNF-α(P<0.01),而减少IL-10 (P <0.05).结论 高压氧可降低健康大鼠外周血CD4T细胞百分比.当出现高炎症反应时,高压氧可以明显抑制细胞因子TNF-α、IL-6和IL-10的爆发增多.高压氧对健康大鼠和未出现高炎症反应的SIRS大鼠起促炎作用.%Objective To investigate the effects of hyperbaric oxygen therapy on T-lymphocytes 1 and cytokines including IL-6, IL-10 and TNF-α as indicators well representing immune function and inflammation in normal rats and rats with systemic inflammatory response syndrome. Methods Forty Sprague-Dawley male Rats were randomly ( random number) divided into five groups.Rats of group A were treated by saline solution (0.9 % NaCl,5 mL/kg),and served as control group; rats of group B were treated with saline solution and hyperbaric oxygen therapy three times; rats of

  12. The effect of hyperbaric oxygenation on rehabilitation of paroxysmal deafness%高压氧对突发性耳聋的康复效果观察

    Institute of Scientific and Technical Information of China (English)

    孙春焕; 王庆霞; 刘怀芹; 秦军

    2001-01-01

    @@Background: The cause of paroxysmal deafness is unknown.It is a nerve deafness that has mostly hearing handicap and harried onset.At present,the disease is usually deemed incurable if it continues for three months.Many scholars consider that handicap of blood circulation in inner ear is an important factor leading to paroxysmal deafness.Hyperbaric oxygenation improves oxygenic content and press in blood. Objective: The effects of hyperbaric oxygenation on rehabilitation of paroxysmal deafness were investigated. Design: 105 patients with paroxysmal deafness were randomly divided into treatment group(n=41)and control group(n=43).Treatment group included 30 patients single ear with deafness of unilateral ear.Control group included 28 patients with deafness of unilateral ear. Unit: Liaocheng People's Hospital. Subject: We collected 105 patients with paroxysmal deafness from May 1999 to Dec 2000.84 patients were male,21 patients were female,aged 7~ 60 years(average 31.9 years).

  13. Oxygen pre-breathing decreases dysbaric diseases in UW sheep undergoing hyperbaric exposure.

    Science.gov (United States)

    Sobakin, A S; Wilson, M A; Lehner, C E; Dueland, R T; Gendron-Fitzpatrick, A P

    2008-01-01

    Prolonged exposure of humans and animals to increased pressure as in a disabled submarine (DISSUB) can saturate the body's tissues with dissolved N2 as compressed air is breathed. Decompression-induced bubble formation in the long bone marrow cavity may lead to a bone compartment syndrome resulting in bone ischemia and necrosis. We tested oxygen pre-breathing prior to decompression in sheep to assess the effect upon dysbaric osteonecrosis (DON) induction in a DISSUB simulation experiment. A total of sixteen adult female sheep were used throughout the experiment. Four sheep were used as controls without oxygen pre-breathing. All sheep (99 +/- 14 kg SD) underwent dry chamber air exposure at 60 fsw (2.79 atm abs) (.2827 MPa) for 24 h followed by oxygen (88-92%) pre-breathing (15-min, 1-h, and 2-h and air for control) before "dropout" decompression at 30 fsw/min (0.91 atm/min). 99mTc-methylene diphosphonate (MDP) bone scans of the distal (radii and tibiae) long bones were used to detect "hot spots" of remodeling suggestive of DON lesions. Alizarin complexone fluorochrome was injected to visualize sites of metabolic activity indicating DON repair of both the proximal and distal long bones (radii, tibiae, femora, and humeri). Our findings showed that the amount of alizarin complexone deposition and bone scan uptake was greater in sheep with shorter oxygen pre-breathing times than those undergoing longer pre-breathing dives (p = 0.0056 and p = 0.001, for one and two hour pre-breathes respectively). Proximal limb bones (femur, humerus) displayed less alizarin complexone deposition than the distal radius and tibia (p < 0.0001).

  14. Delayed Encephalopathy of Carbon Monoxide Intoxication and Treatment with Hyperbaric Oxygen: A Case Report

    Directory of Open Access Journals (Sweden)

    Fatma Polat

    2012-09-01

    Full Text Available Delayed encephalopathy (DE is a neuropsychiatric syndrome that can arise generally within 20 days of acute carbon monoxide (CO intoxication after apparent recovery and involves variable degrees of cognitive deficits, personality changes, movement disorders and focal neurologic deficits. We report a 35-year-old female patient with delayed encephalopathy due to CO intoxication, presenting with cognitive impairment and mild parkinsonism despite receiving hyberbaric oxigen therapy (HBO. Magnetic resonance imaging showed abnormal signal intensity and decreased diffusivity at both caudate nuclei and globus pallidus. She continued to receive additional HBO therapy and complete recovery was reached within six months. The positive effect of early HBO therapy of selected patients in reversing the acute effects of CO intoxication is appearant. We here also review the beneficial effect of HBO in preventing or limitating the late neurocognitive deficits associated with severe CO intoxication.

  15. The debate on continuous home oxygen therapy.

    Science.gov (United States)

    Díaz Lobato, Salvador; García González, José Luis; Mayoralas Alises, Sagrario

    2015-01-01

    Two studies published in the early 80s, namely the Nocturnal Oxygen Therapy Trial (NOTT) and the Medical Research Council Trial (MRC), laid the foundations for modern home oxygen therapy. Since then, little progress has been made in terms of therapeutic indications, and several prescription-associated problems have come to light. Advances in technology have gone hand in hand with growing disregard for the recommendations in clinical guidelines on oxygen therapy. The introduction of liquid oxygen brought with it a number of technical problems, clinical problems related to selecting candidate patients for portable delivery devices, and economic problems associated with the rising cost of the therapy. Continuous home oxygen therapy has been further complicated by the recent introduction of portable oxygen concentrators and the development in quick succession of a range of delivery devices with different levels of efficiency and performance. Modern oxygen therapy demands that clinicians evaluate the level of mobility of their patients and the mobility permitted by available oxygen sources, correctly match patients with the most appropriate oxygen source and adjust the therapy accordingly. The future of continuous home oxygen therapy lies in developing the ideal delivery device, improving the regulations systems and information channels, raise patient awareness and drive research. Copyright © 2014 SEPAR. Published by Elsevier Espana. All rights reserved.

  16. Effect of hyperbaric oxygen and vitamin C and E supplementation on biomarkers of oxidative stress in healthy men

    DEFF Research Database (Denmark)

    Bader, Nicolle; Bosy-Westphal, Anja; Koch, Andreas

    2007-01-01

    The objectives of the present study were to evaluate the effect of normobaric and hyperbaric O2 (HBO) on plasma antioxidants and biomarkers of oxidative stress in plasma and urine and to investigate the effect of a 4-week vitamin C plus E supplementation on HBO-induced oxidative stress. Nineteen...

  17. Effects of Exercise Training under Hyperbaric Oxygen on Oxidative Stress Markers and Endurance Performance in Young Soccer Players: A Pilot Study

    Directory of Open Access Journals (Sweden)

    Carlos Burgos

    2016-01-01

    Full Text Available The aim of the present study was to determine the effects of three weeks of hyperbaric oxygen (HBO2 training on oxidative stress markers and endurance performance in young soccer players. Participants (18.6±1.6 years were randomized into hyperbaric-hyperoxic (HH training (n=6 and normobaric normoxic (NN training (n=6 groups. Immediately before and after the 5th, 10th, and 15th training sessions, plasma oxidative stress markers (lipid hydroperoxides and uric acid, plasma antioxidant capacity (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid [TROLOX], arterial blood gases, acid-base balance, bases excess (BE, and blood lactate analyses were performed. Before and after intervention, maximal oxygen uptake (VO2max and peak power output (PPO were determined. Neither HH nor NN experienced significant changes on oxidative stress markers or antioxidant capacity during intervention. VO2max and PPO were improved (moderate effect size after HH training. The results suggest that HBO2 endurance training does not increase oxidative stress markers and improves endurance performance in young soccer players. Our findings warrant future investigation to corroborate that HBO2 endurance training could be a potential training approach for highly competitive young soccer players.

  18. Effects of Exercise Training under Hyperbaric Oxygen on Oxidative Stress Markers and Endurance Performance in Young Soccer Players: A Pilot Study

    Science.gov (United States)

    Henríquez-Olguín, Carlos; Andrade, David Cristóbal; Ramírez-Campillo, Rodrigo; White, Allan; Cerda-Kohler, Hugo

    2016-01-01

    The aim of the present study was to determine the effects of three weeks of hyperbaric oxygen (HBO2) training on oxidative stress markers and endurance performance in young soccer players. Participants (18.6 ± 1.6 years) were randomized into hyperbaric-hyperoxic (HH) training (n = 6) and normobaric normoxic (NN) training (n = 6) groups. Immediately before and after the 5th, 10th, and 15th training sessions, plasma oxidative stress markers (lipid hydroperoxides and uric acid), plasma antioxidant capacity (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid [TROLOX]), arterial blood gases, acid-base balance, bases excess (BE), and blood lactate analyses were performed. Before and after intervention, maximal oxygen uptake (VO2max) and peak power output (PPO) were determined. Neither HH nor NN experienced significant changes on oxidative stress markers or antioxidant capacity during intervention. VO2max and PPO were improved (moderate effect size) after HH training. The results suggest that HBO2 endurance training does not increase oxidative stress markers and improves endurance performance in young soccer players. Our findings warrant future investigation to corroborate that HBO2 endurance training could be a potential training approach for highly competitive young soccer players. PMID:28083148

  19. Hyperbaric programs in the United States: Locations and capabilities of treating decompression sickness, arterial gas embolisms, and acute carbon monoxide poisoning: survey results.

    Science.gov (United States)

    Chin, Walter; Jacoby, Laura; Simon, Olivia; Talati, Nisha; Wegrzyn, Gracelene; Jacoby, Rachelle; Proano, Jacob; Sprau, Susan E; Markovitz, Gerald; Hsu, Rita; Joo, Ellie

    2016-01-01

    Hyperbaric oxygen therapy is the primary treatment for arterial gas embolism, decompression sickness and acute carbon monoxide poisoning. Though there has been a proliferation of hyperbaric centers throughout the United States, a scarcity of centers equipped to treat emergency indications makes transport of patients necessary. To locate and characterize hyperbaric chambers capable of treating emergency cases, a survey of centers throughout the entire United States was conducted. Using Google, Yahoo, HyperbaricLink and the UHMS directory, a database for United States chambers was created. Four researchers called clinicians from the database to administer the survey. All centers were contacted for response until four calls went unreturned or a center declined to be included. The survey assessed chamber readiness to respond to high-acuity patients, including staff availability, use of medical equipment such as ventilators and intravenous infusion devices, and responding yes to treating hyperbaric emergencies within a 12-month period. Only 43 (11.9%, N = 361) centers had equipment, intravenous infusion pumps and ventilators, and staff necessary to treat high-acuity patients. Considering that a primary purpose of hyperbaric oxygen therapy is the treatment of arterial gas embolism and decompression sickness, more hyperbaric centers nationwide should be able to accommodate these emergency cases quickly and safely.

  20. 大隐静脉电凝术结合高压氧治疗下肢静脉性溃疡%Clinical research on hyperbaric oxygen and electrocoagulation in the treatment of venous ulcers on legs

    Institute of Scientific and Technical Information of China (English)

    王宏业; 杨秀义; 杨秀峰

    2012-01-01

    Objective To observe the clinical effect of hyperbaric oxygen and electrocoagulation in the treatment of venous ulcers on legs.Methods 36 patients with venous ulcer on legs were divided into group A of 12 cases,group B of 12 cases and group C of 12 cases.Group A was treated by hyperbaric oxygen and electrocoagulation;group B was treated by hyperbaric oxygen;group C was treated by electrocoagulation.The operation method:every one had been performed electrocoagulation,and performed improved Linton operation if traffic vein valve had functional disorder,and performed wearing ring operation if vein reflux exceed Ⅲ °.Results The time of healing:group A was ( 18.00 ± 4.66) days,group B was (28.20 ± 6.42 ) days and group C was (31.32 ± 4.88 ) days.The time was significantly different between the two groups( A and B,P <0.01 ;A and C,P <0.01 ; B and C,P < 0.05).29 cases had been investigated by 6 to 40 months,the venous ulcers on legs had no recurrence.Conclusion The treatment for venous ulcer on legs by hyperbaric oxygen and electrocoagulation was a new therapy which had advantage of healing quickly and less recurrence,It ought to be popularized.%目的 观察大隐静脉电凝术结合高压氧治疗下肢静脉性溃疡的临床效果.方法 36例下肢静脉性溃疡,随机分为三组,A组(电凝术结合高压氧组)12例,B组(高压氧组)12例,C组(电凝术组)12例.手术方法:行大隐静脉电凝术,交通静脉瓣膜功能不全,采用改良的Linton手术,Ⅲ°以上反流者行戴戒术.结果 愈合时间:A组( 18.00±4.66)d,B组(28.20±6.42)d,C组(31.32±4.88)d.三组差异有统计学意义(F=8.93,P<0.05);A组与B组、C组差异均有统计学意义(q=4.62、7.81,均P<0.01);B组与C组差异有统计学意义(q =3.76,P<0.05).36例中29例获随访,随访时间6~40个月,下肢静脉曲张及溃疡均无复发.结论 大隐静脉电凝术结合高压氧治疗下肢静脉性溃疡,溃疡愈合快,不易复发,是一种新型治疗方法,疗效肯定,值得推广.

  1. Clinical and pathological study on the hyperbaric oxygenation treatment ofchronic hepatitis

    Institute of Scientific and Technical Information of China (English)

    Wei Zhao; Wei Liu

    2000-01-01

    AIM To study the effect and alteration of hepatic blood flow as well as ultrastructure of hepatic tissue inchronic cholestatic hepatitis after hypebaric oxygenation (HBO).METHODS Using the hepatic rheometer and Doppler B-mode ultrasound equipment, the contractive waveof hepatic blood flow and blood flow of portal vein were tested; the biochemistry, immunohistochemistryand ultrastructure of hepatic tissue were determined and served as the evaluating indexes.RESULTS After the HBO treatment, the contractive wave of hepatic blood-flow in 76% patients and bloodof right portal vein in 70% patients were increased, the improvement of serum ALT and BILI was 88.9%and 93.3% respectively. In addition, the swelling mitochondria, cholestasis of hepatic cells and capillariesreduced obviously; Kupffer's cells decreased. There was significant difference (t=2.85, P<0.05) beforeand after HBO treatment.CONCLUSION It is suggested that the HBO could increase the blood flow of portal vein and arteries,improve the hepatic function, cholestatsis and inflammation.

  2. Effect of hyperbaric oxygen preconditioning on the expression of aquaporin 5 in rats with high-altitude pulmonary edema

    Institute of Scientific and Technical Information of China (English)

    LI Zhuo; ZHAO Li-ming; WANG Cong; LIU Xue-hua; GAO Chun-jin

    2012-01-01

    Objective To investigate the possibility of applying hyperbaric oxygen preconditioning(HBO-PC)to reduce or prevent high-altitude pulmonary edema(HAPE)and to detect whether aquaporin 5(AQP5)are involved in HAPE pathogenesis.Methods Thirty eight rats were divided into three groups:the control,the HBO-PC and the HAPE groups.Western blot and real-time PCR were used to analyze the expression of AQP5 in the lungs.The wet-to-dry weight ratio(W/D weight ratio)and morphology of the lung were also examined.Results Lung W/D weight ratio in the HAPE group(4.36±0.53)compared with that of the control group(3.90±0.15)(P<0.05),were marked interstitial edema in all the lung sections in the HAPE group,and fewer changes in 10 of 13 sections in the HBO-PC group.Lung-injury scores of the HBO-PC group were much lower than those of the HAPE group.AQP5 of the HAPE group decreased significantly at the protein and gene levels compared with those in the control group(P<0.01,P<0.05).Protein and mRNA expression of AQP5 in the HBO-PC group were much higher than those of the HAPE group(P<0.05,P<0.01).Lung injuries in the HAPE rats were related positively to the AQP5 expression in the lung(protein expression r=-0.635,P<0.01;mRNA expression r=-0.399,P<0.05).Conclusions We concluded that HBO-PC could alleviate lung injury in rats caused by high-altitude hypobaric hypoxia and reduce HAPE incidence.HAPE in rats was associated with the down-regulation of expression of AQP5 in the lungs.This down-egulation could be attenuated by HBO-PC.This study is the first one introducing HBO-PC in the prevention of HAPE,and the first investigation on the expression of AQP5 in a rat model of HAPE.

  3. Pediatric Oxygen Therapy: A Review and Update.

    Science.gov (United States)

    Walsh, Brian K; Smallwood, Craig D

    2017-06-01

    Oxygen is a colorless, odorless, tasteless gas that is utilized by the body for respiration. Oxygen has played a major role in respiratory care. Oxygen therapy is useful in treating hypoxemia but is often thought of as a benign therapy. After many years of study, we have learned a great deal of the benefits and potential risk of this powerful drug. Today oxygen gas is cheap, widely available, and easy to administer. Oxygen delivery devices vary in cost from a few cents for a simple nasal cannula to $25-$50 for some humidified systems. Undoubtedly, oxygen therapy is an important tool and has saved many lives and improved others. However, oxygen therapy risk, cost, and benefits should be considered in the same way as other drugs and titrated to a measured end point to avoid excessive or inadequate dosing. Withholding oxygen can have a detrimental effect, yet continuing to provide oxygen therapy when it is no longer indicated can prolong hospitalization and increase the cost of care. This comprehensive review begins with an assessment of need and a review of physiologic effects, potential toxicities, and common delivery devices, and it ends with advances in oxygen therapy with a focus on the pediatric patient. Copyright © 2017 by Daedalus Enterprises.

  4. Hyperbaric oxygen in the treatment of hypertension- induced cerebral hemorrhage on 34 cases%高血压脑出血术后高压氧治疗34例

    Institute of Scientific and Technical Information of China (English)

    程晋成; 沈月萍; 王水平; 吴杨

    2003-01-01

    @@ INTRODUCTION In this study,we investigated effect of hyperbaric oxygen(HBO) on the hypertension- induced basio- cerebral hemorrhage.The affected patients often showed signs of cerebral circulation disorder,spasm of vessels,insufficiency of cerebral blood supply and intracranial hypertension.

  5. 高压氧对皮肤磨削术后创面愈合的影响%Effect of skin dermabrasion on wound healing promoted by hyperbaric oxygen

    Institute of Scientific and Technical Information of China (English)

    任纪祯; 陈振雨; 王彦进; 陈璐

    2014-01-01

    目的 探讨高压氧治疗在面部瘢痕皮肤磨削术后创面愈合中的作用.方法 将行面部瘢痕皮肤磨削术患者32例(痤疮后凹陷性瘢痕20例,外伤后条索状线性瘢痕12例),随机分为两组:16例为高压氧治疗组,于术后第1天开始给予高压氧干预,每日1次,连续6d;另外16例作为对照组,只给予常规术后换药处理,换药程序与高压氧治疗组相同,观察高压氧治疗组与对照组在磨削术后创面换药天数及愈合时间上的差异.结果 16例磨削创面进行高压氧治疗后创面愈合较快,平均换药时间为(4.0±1.2)d,平均愈合时间为(11.0±2.8)d,无创面感染.对照组16例磨削创面愈合较慢,平均换药时间为(5.0±1.6)d,平均愈合时间为(16.0±3.1)d,无创面感染.两组患者以供皮区创面内层敷料完全自然翘起,可轻易揭除,揭除的时间为判定愈合标准,两组愈合时间比较差异有统计学意义(P<0.05),换药天数差异无统计学意义(P>0.05).结论 面部瘢痕皮肤磨削术后行高压氧治疗可以促进磨削区创面愈合,缩短愈合时间.%Objective To study the function of hyperbaric oxygen in the wound healing of skin dermabrasion.Methods A total of 32 cases of facial scar underwent skin dermabrasion,in which 20 cases were caused by acne and 12 cases by external injury.16 cases were given hyperbaric oxygen treatment after skin dermabrasion randomly and lasted for 6 days,while the other 16 cases were given only routine dressing change which was same to the hyperbaric oxygen group.We observed the wound healing time and dress changing time under the condition of hyperbaric oxygen and no hyperbaric oxygen after skin dermabrasion.Results Sixteen cases received hyperbaric oxygen recovered with short healing time,average 11 days,while other 16 cases received no hyperbaric oxygen recovered with longer healing time,average 16 days,without wound infection.Significant statistical difference (P<0.05) was found by

  6. 尼麦角林联合高压氧治疗血管性认知功能障碍疗效观察%Efficacy of nicergline combined with hyperbaric oxygen treatment on vascular cognitive impairment

    Institute of Scientific and Technical Information of China (English)

    陈国军; 张燕柳; 张惠莉; 于永娜; 宋帅召

    2015-01-01

    ADL were improved in hyperbaric oxygen group (both P<0.05).There were significant differences in scores of MMSE,WMS and ADL between combination therapy group and nicergoline group,hyperbaric oxygen group after treatment (all P<0.05).But only MMSE had significant difference between niccrgoline group and hyperbaric oxygen group after treatment.No significant side effects were observed in the three groups.Conclusions Combination treatment of nicergline and hyperbaric oxygen has better efficacy on vascular cognitive impairment.It can markedly improve the activities of daily living and cognitive function without significant side effects,which is worthy of application in clinical medicine.

  7. 高压氧对口腔牙菌斑幽门螺杆菌的作用%Effects of hyperbaric oxygenation to helicobacter pylori in dental plaque

    Institute of Scientific and Technical Information of China (English)

    陈发明; 孙海花; 贾保军; 邓玲玲; 曲淑华

    2001-01-01

    AIM:To investige the treatment ef fect s and mechanism of hyperbaric oxygenation(HBO) to helicobacter pylori(Hp) in den tal plaque. METHODS:120 patients of second degree period ontitis (Hp-PCR positive) were divided into 4 groups: The changes of periodontal measur ements compared at 1,3,6 months post treatment. RESULTS: T he Hp positive rate showed significant difference between 4 groups and they were 96.7%, 80.0%, 73.3%, 0 after 6 mouths. The effect of treatment of group D was the best (P<0.01), better than those of other groups(P<0.05). CONCLUSION:HBO may kill Hp in dental plaque effectively when patients received treatment of oral prophylax is and Triple therapy.%目的:寻找一种较为理想的根除口腔幽门 螺杆菌(Hp)的方法。方法:将120例口腔牙菌斑Hp-PCR检测阳性的Ⅱ 度牙周炎患者分为A、B、C、D 4组,治疗1、3、6月后分别对所有患者牙周参数和龈下 菌斑进行Hp-PCR检测并比较检测结果。结果:4组Hp阳性率分别为96 .7%、80.0%、73.3%和0,有显著性差异(P<0.05),其中以D组最低(P<0.01);临床 牙周参数变化亦有显著差别(P<0.05)。结论:高压氧对口腔Hp 有明显抑制或杀灭作用,高压氧配合治疗,有助于口腔 Hp 的根除和与Hp有关的疾病的治疗。

  8. 鼓室内注射糖皮质激素或高压氧治疗难治性突发性耳聋%Therapeutic Efficacy of Intratympanic Corticosteroid or Hyperbaric Oxygen for Refractory Sudden Hearing Loss

    Institute of Scientific and Technical Information of China (English)

    李彩云; 吴旋

    2014-01-01

    目的:分析鼓室内注射糖皮质激素或高压氧治疗难治性突发性耳聋的疗效。方法:选择68例(68耳)临床诊断突发性耳聋、经全身糖皮质激素治疗无效的患者,随机分为三组,分别采用鼓室内注射糖皮质激素治疗组、高压氧治疗组和对照组,观察和比较各组治疗效果。结果:鼓室内注射糖皮质激素治疗组总有效率为50.0%,高压氧治疗组总有效率为44.0%,均比对照组高,差异有统计学意义(P0.05)。结论:鼓室内注射糖皮质激素或高压氧对难治性突发性聋有效,可提高疗效,改善听力。%Objective:To determine the therapeutic efficacy of intratympanic corticosteroid or hyperbaric oxygen for refractory sudden hearing loss. Method:68 cases of refractory sudden deafness were treated respectively by intratympanic corticosteroid or hyperbaric oxygen or control.Result:Total effective rate of intratympanic corticosteroid and hyperbaric oxygen were 50.0%and 44.0%,respectively. Compared with control group,there were significant differences(P<0.05). Intratympanic corticosteroid showed no better effect on sudden hearing loss than hyperbaric oxygen alone.Conclusion:Intratympanic corticosteroid or hyperbaric oxygen may be considered as treatment option for refractory sudden hearing loss.

  9. Staffing and training issues in critical care hyperbaric medicine.

    Science.gov (United States)

    Kot, Jacek

    2015-03-01

    The integrated chain of treatment of the most severe clinical cases that require hyperbaric oxygen therapy (HBOT) assumes that intensive care is continued while inside the hyperbaric chamber. Such an approach needs to take into account all the risks associated with transportation of the critically ill patient from the ICU to the chamber and back, changing of ventilator circuits and intravascular lines, using different medical devices in a hyperbaric environment, advanced invasive physiological monitoring as well as medical procedures (infusions, drainage, etc) during long or frequently repeated HBOT sessions. Any medical staff who take care of critically ill patients during HBOT should be certified and trained according to both emergency/intensive care and hyperbaric requirements. For any HBOT session, the number of staff needed for any HBOT session depends on both the type of chamber and the patient's status--stable, demanding or critically ill. For a critically ill patient, the standard procedure is a one-to-one patient-staff ratio inside the chamber; however, the final decision whether this is enough is taken after careful risk assessment based on the patient's condition, clinical indication for HBOT, experience of the personnel involved in that treatment and the available equipment.

  10. 早期应用高压氧对脑梗死患者日常生活活动能力的影响%The effect of early hyperbaric oxygenation on ability of daily life of patients with stroke

    Institute of Scientific and Technical Information of China (English)

    杨晓娟; 李凯; 何韬

    2003-01-01

    BACKGROUND:Brain tissue is often thought as the most vigorous organ and is very sensitive to hypoxia.Hyperbaric oxygenation means improving blood oxygen content for decreasing the brain harm caused by stroke.Anaerobic metabolism of brain tissue decreases and aerobic metabolism increases,which cause more power and accelerate clearing of acidic product of metabolism,so provide fine material base for regeneration of neural tissue and recovery of neural function.

  11. The history of subcutaneous oxygen therapy.

    Science.gov (United States)

    Curry, Timothy B; Bacon, Douglas R; Rho, Richard H

    2006-08-01

    Soon after the discovery of oxygen, experiments began on the use of oxygen for therapeutic purposes, including subcutaneous administration of oxygen, on humans and animals. The history of subcutaneous oxygen therapy (SQOT) is examined in the context of the growing understanding of the use and methods of oxygen administration. Little was written about this therapy until the 19th century, despite an advocacy for its use in some circles. There was resurgence in the use of SQOT in the early 20th century. Investigators in the field of anesthesia, including such notable figures as Paul M. Wood, Ralph M. Waters, and John Henry Evans, contributed to the growth in popularity of the therapy and to the literature on the subject. Although SQOT has been supplanted by other means of administration, it may have a role in management of some inflammatory or pain conditions.

  12. Optimal Use of Hyperbaric Oxygen Therapy in Military Medical Setting (Utilisation optimale de loxygnothrapie hyperbare dans le contexte militaire)

    Science.gov (United States)

    2016-02-01

    Poisoning 3-7 3.6 Crush Injury (Combined Trauma to Bones, Soft Tissue, Vessels, or Nerves) 3-8 3.7 Decompression Sickness – Life-Threatening 3-9...HBO A-6 A.4.3.1 In Vitro Studies A-6 A.4.3.2 In Vivo (Animal – Human) A-6 A.4.4 Clinical Scientific Evidence A-7 A.5 Carbon Monoxide Poisoning ...MICHAUD (As from 2012) Bureau of Medicine and Surgery Head, Undersea Medicine and Radiation Health (M3B3) 2300 E Street, NW Washington, DC

  13. 高压氧辅助药物治疗动脉粥样硬化脑血管痉挛随机对照研究%Effect of hyperbaric oxygen combined with drug on patients with atherosclerotic cerebral vasospasm

    Institute of Scientific and Technical Information of China (English)

    辜忠灵

    2014-01-01

    目的:分析高压氧辅助药物治疗动脉粥样硬化脑血管痉挛的效果。方法选择在本院接受住院治疗的动脉粥样硬化脑血管痉挛患者作为研究对象,分别给予单纯药物治疗及高压氧辅助药物治疗,比较有效率、血液学指标、基底动脉管径及NO、NOS、Ca2+含量等。结果观察组有效率(97.06%)、基底动脉管径[(4.98±1.35)mm]、NO [(59.43±11.48)μmol/L]、NOS[(98.43±14.38)kU/L]均明显高于对照组;胆固醇[(3.12±0.72)mmol/L]、甘油三酯[(1.27±0.41)mmol/L]、血小板计数[(112.74±13.36)×109/L]、血黏度[(1.21±0.37) mPa · s]、[Ca2+(17.07±1.65)g/μmol]明显低于对照组( P<0.05)。结论高压氧辅助药物可有效提高动脉粥样硬化脑血管痉挛患者的临床疗效,优化血液学指标,升高基底动脉管径、NO及NOS ,减少Ca2+含量,具有积极的临床意义。%Objective To analyze the efficacy of hyperbaric oxygen combined with drug on patients with atherosclerotic cerebral vasospasm. Methods Patients with atherosclerotic cerebral vasospasm admitted to our hospital were chosen as re-search subjects ,and divided into observation group and control group. The control group was given drug therapy alone and the observation group was given hyperbaric oxygen combined with drug therapy. The efficiency of treatment ,hematological index , and basilar artery diameter ,NO ,NOS ,Ca2+ level of the two groups were compared. Results The efficacy rate (97.06% ) ,bas-al artery diameter(4.98 ± 4.98) mm ,NO(59.43 ± 11.48)μmol/L ,NO (98.43 ± 14.38) kU/L of observation group were sig-nificantly higher than those of the control group ;Cholesterol(3.12 ± 0.72) mmol/L ,triglycerides(1.27 ± 0.41) mmol/L , platelet count(112.74 ± 13.36)109/L ,blood viscosity(1.21 ± 0.37 )mPa · s ,Ca2+ (17.07 ± 1.65) g/μmol were significantly lower than those of the control group(P<0.05).Conclusion Hyperbaric oxygen

  14. Oxygen therapy multicentric study--a nationwide audit to oxygen therapy procedures in internal medicine wards.

    Science.gov (United States)

    Neves, J T; Lobão, M J

    2012-01-01

    Oxygen therapy is a common and important treatment in Internal Medicine wards, however, several studies report that it isn't provided accordingly with the best of care. The goal of this work is to evaluate oxygen therapy procedures in Portuguese Internal Medicine wards, comparing them to the standards established by the British Thoracic Society (BTS) in its consensus statement "BTS guideline for emergency oxygen use in adult patients". Between September 3rd and 23rd 2010, each one of the 24 enrolled hospitals audited the oxygen therapy procedures for one randomly chosen day. All Internal Medicine inpatients under oxygen therapy or with oxygen prescription were included. Data was collected regarding oxygen prescription, administration and monitoring. Of the 1549 inpatients, 773 met inclusion criteria. There was an oxygen prescription in 93,4%. Most prescriptions were by a fixed dose (82,4%), but only 11,6% of those stated all the required parameters. Absence of oxygen therapy duration and monitoring were the most frequent errors. Oxygen was administered to only 77,0% of the patients with fixed dose prescriptions. FiO(2) or flow rate and the delivery device were the same as prescribed in 70,9 and 89,2% of the patients, respectively. Out of the 127 patients with oxygen therapy prescriptions by target SatO(2) range, 82,7% were on the prescribed SatO(2) objective range. Several errors were found in oxygen therapy procedures, particularly regarding fixed dose prescriptions, jeopardizing the patients. Although recommended by BTS, oxygen therapy prescriptions by target SatO(2) range are still a minority.

  15. Wireless transmission of biosignals for hyperbaric chamber applications

    OpenAIRE

    Perez-Vidal, Carlos; Gracia, Luis; Carmona, Cristian; Alorda, Bartomeu; Salinas, Antonio

    2017-01-01

    This paper presents a wireless system to send biosignals outside a hyperbaric chamber avoiding wires going through the chamber walls. Hyperbaric chambers are becoming more and more common due to new indications of hyperbaric oxygen treatments. Metallic walls physically isolate patients inside the chamber, where getting a patient?s vital signs turns into a painstaking task. The paper proposes using a ZigBee-based network to wirelessly transmit the patient's biosignals to the outside of the cha...

  16. THERAPEUTIC EFFECT OF HYPERBARIC OXPGEN COMBINED WITH OCCUPATIONAL THERAPY IN STORKE PATIENTS%作业疗法和高压氧联合治疗脑卒中的临床观察

    Institute of Scientific and Technical Information of China (English)

    钟思琳; 曾德良; 黄鲁敏; 梁宇健

    2015-01-01

    Objective To evaluate the efficacy and safety of the combined treatment of occupational therapy and hyperbaric oxygen in patients with stroke.Methods 100 cases of stroke patients treated in our department from October, 2012 to October, 2014 were divided randomly into treatment group (n=50) and control group (n=50).They were all treated with Bobath therapy and acu-puncture and routine rehabilitation training .The treatment group used occupational therapy and hyperbaric oxygen therapy based on the above.Fugl-Meyer scale was used to assess the extremity motor function and Barthel index ( BI) was used to assess ADL before and after treatment.Results The treatment group had a significantly higher excellent rate, Fugl-Meyer score and Barthel index, lower side-effect rate as compared with the control group (p<0.05).Conclusion The combined therapy of occupational therapy and hyperbaric oxygen can significantly improve the motor function and ability of daily living in patients with stroke , and further im-prove rehabilitation effect.%目的:评价作业疗法和高压氧联合治疗脑卒中的疗效及安全性。方法将2012年10月~2014年10月收治的100例脑卒中患者,随机分为治疗组和对照组各50例。对照组行常规的康复治疗,包括应用 Bobath 疗法为主,结合PNF、Rood等促通技术和运动再学习法,传统医学康复手段(针灸、推拿),物理因子(低、中频电等)方法进行康复治疗和针灸等;治疗组在此基础上给予作业疗法和高压氧联合治疗。对患者治疗前后分别进行 Fugl-Meyer运动评分( FMA)及改良Barthel指数(MBI)的日常生活能力评分。结果治疗组治疗前、后Fugl-Meyer运动评分(FMA)及改良 Barthel指数(MBI)的日常生活能力评分明显优于对照组,差异有统计学意义( p<0.05)。结论作业疗法和高压氧联合治疗能够显著改善脑卒中患者运动功能及日常生活能力,进一步提高康复效果。

  17. 早期高压氧治疗婴幼儿外伤后基底节区脑梗死疗效分析%Effect of Early Hyperbaric Oxygen on Traumatic Basal Ganglia Infarction in Infants and Children

    Institute of Scientific and Technical Information of China (English)

    张红霞; 于秋红; 刘亚玲; 薛连璧

    2011-01-01

    目的 探讨早期应用高压氧治疗婴幼儿外伤后基底节区脑梗死的效果。方法 回顾性分析93例婴幼儿外伤后基底节区脑梗死的临床资料。将93例患儿分为两组:高压氧组60例和对照组33例。结果 高压氧组有效率100%,治愈率93.33%;对照组有效率81.82%,治愈率75.76%(P<0.05)。结论 早期高压氧是一种安全、有效治疗婴幼儿外伤后基底节区脑梗死的方法。%Objective To investigate the effect of early hyperbaric oxygen on traumatic basal ganglia infarction in infants and children. Methods 93 cases with basal ganglia infarction after cerebral trauma were reviewed. They were divided into hyperbaric oxygen group (n= 60) and control group (n=33). Results 100% of the hyperbaric oxygen group improved, and 93.33% were cured; it was 81.82% and 75.76% in the control group (P<0.05). Conclusion Early hyperbaric oxygen is safe and effective on traumatic basal ganglia infarction in infants and children.

  18. Protective effect of hydrogen sulfide on hyperbaric hyperoxia-induced lung injury in a rat model.

    Science.gov (United States)

    Liu, Wenwu; Liu, Kehuan; Ma, Chunqing; Yu, Jiangang; Peng, Zhaoyun; Huang, Guoyang; Cai, Zhiyu; Li, Runping; Xu, Weigang; Sun, Xuejun; Liu, Kan; Zheng, Juan

    2014-01-01

    Hyperbaric oxygen therapy is one of the most widely used clinical interventions to counteract insufficient pulmonary oxygen delivery in patients with severe lung injury. However, prolonged exposure to hyperoxia leads to inflammation and acute lung injury. This study aimed to investigate the protective effect of hydrogen sulfide on hyperbaric hyperoxia-induced lung injury. Rats were intraperitoneally treated with sodium hydrosulphide (NaHS) at 28 μmol/kg immediately before hyperoxia exposure and then exposed to pure oxygen at 2.5 atmospheres absolute (atm abs) with continuous ventilation for six hours, Immediately after hyperoxia exposure, rats were sacrificed via anesthesia. The bronchoalveolar lavage fluid (BALF) was harvested for the detection of protein concentration and IL-1 content, and the lungs were collected for HE staining, TUNEL staining and detection of wet/dry weight ratio. Our results showed hyperbaric hyperoixa exposure could significantly damage the lung (HE staining), increase the protein and IL-13 in the BALF, elevate the wet/dry Weight ratio and raise the TUNEL positive cells. However, pre-treatment with hydrogen sulfide improved the lung morphology, reduced the TUNEL positive cells and attenuated the lung inflammation (reduction in IL-13 of BALF and HE staining). Taken together, our findings indicate that hydrogen sulfide pretreatment may exert protective effects on hyperbaric hyperoxia-induced lung injury.

  19. Anton syndrome during oxygen-ozone therapy.

    Science.gov (United States)

    Avcı, Sema; Büyükcam, Fatih; Demir, Ömer Faruk; Özkan, Seda

    2015-06-01

    Ozone (O₃) gas is a molecule that consists of 3 oxygen atoms, found out in the mid-19th century [1]. Ozone gas preserves humans from detrimental influences of ultraviolet radiation [1]. In spite of harmful effects of O₃ gas, investigators think that it has excessive curative effects [1]. Nowadays, O₃ therapy is used for many fields of medicine in precise therapeutic doses [1] and [2]. It is known that O₃ therapy is helpful in dental procedures, cerebrovascular diseases, tinnitus, acquired immunodeficiency syndrome, hypercholesterolemia, sensorial hypoacusis, senile dementia, multiple sclerosis, irradiation sensitive tumors, herpes simplex and herpes zoster virus infections, muscular hypertonia, and chronic otitis media, etc.[2]. The complications and disadvantages of O₃ therapy could be observed in the future. Herein, we presented a case of ischemic stroke after an oxygen-O₃ therapy, which is called also Anton syndrome.

  20. Changes in brain function and anatomical structure following treatment of hyperbaric oxygen for visual pathway abnormalities In 16 cases Evaluation of functional magnetic resonance Imaging combined with diffusion tensor imaging

    Institute of Scientific and Technical Information of China (English)

    Ziqian Chen; Ping Ni; Hui Xiao; Jinhua Chen; Gennian Qian; Youqiang Ye; Shangwen Xu; Jinliang Wang; Xizhang Yang

    2008-01-01

    BACKGROUND:There is a growing research focus on the combination of blood oxygenation level dependent functional magnetic resonance imaging(BOLD-fMRI)and diffusion tensor imaging(DTI)to evaluate visual cortical function and structural changes in the cerebrum,as well as morphological changes to the white matter fiber tracks,after visual pathway lesions.However,the combined application of BOLD-fMRI and DTI in treating of visual pathway abnormalities still requires further studies. OBJECTIVE:To observe and evaluate the effects of hyperbaric oxygen on visual pathway abnormalities,and to evaluate the characteristics of cerebral function and anatomic structural changes by using BOLD-fMRI combined with DTI technique. DESIGN:Case contrast observation. SETTING:Fuzhou General Hospital of Nanjing Military Area Command of Chinese PLA.PARTICIPANTS:Sixteen patients(9 males and 7 females,15-77 years old)with lateral or bilateral visual disorder induced by visual pathway lesions were selected from the Department of Neurology,Fuzhou General Hospital of Nanjing Military Area Command of Chinese PLA from January 2006 to May 2007.These patients comprised the lesion group.Measures of interventional therapy:hyperbaric oxygen of two normal atmospheres for three courses(10 d/course)and routine internal medicine treatment.In addition,12 healthy subjects of similar sex and age to the lesion group were regarded as the control group.The control group underwent routine ophthalmological and ocular fundus examinations; diagnostic results were normal. The experiment received confirmed consent from the local ethic committee,and all patients provided informed consent.METHODS:BOLD-fMRI and DTI manifestations in the lesion group were observed before and after hyperbaric oxygen intervention,and the results were compared with the control group.The subjects were positioned on their back,and BOLD-fMRI images were collected with the following GRE EPI sequence:TR= 2 000 ms,TE=40 ms,layer thickness=5 mm

  1. 高压氧治疗噪声性听损的实验研究%EXPERIMENTAL STUDY ON NOISE HEARING DAMAGE BY HYPERBARIC EN THERAPY

    Institute of Scientific and Technical Information of China (English)

    王国山; 顾立铭; 姚宏伟; 何冬宁; 徐锡坤

    2000-01-01

    目的探讨高压氧治疗噪声性听力损伤的作用机理和疗效。方法将声损伤豚鼠分别进行高压氧(Ⅰ)、复方丹参(Ⅱ)、高压氧+复方丹参(Ⅲ)治疗。疗程结束后测定脑干听区诱发电位听阈的变化及耳蜗的葡萄糖、丙酮酸含量。结果葡萄糖含量噪声损伤组低于对照组,高压氧组(Ⅰ)高于噪声损伤组;丙酮酸含量噪声损伤组与其它组均有差异;丙酮酸/葡萄糖比值高压氧组(Ⅰ)、高压氧+丹参组(Ⅲ)均低于噪声损伤组,噪声损伤组高于对照组。高压氧组(Ⅰ)听力损失12.5dB(A),高压氧+丹参组(Ⅲ)听力损伤仅为2.5dB(A)。结论高压氧治疗噪声性听力损伤有肯定的疗效,高压氧+丹参治疗噪声性听力损伤有协同作用,而丹参单独治疗尚不能认为有效。%Objective To study the mechanisms of action and the curative effect of the hyperbaric oxygen treating the noiseinduced hearing impairment. Methods Hearing impaired guinea pigs were treated separately with hyperbaric oxygen (Ⅰ), radix salviae miltiorrhiza co (Ⅱ) , hyperbaric oxygen and radix salviae miltiorrhiza co(Ⅲ). Measure the audition threshold change of the brain stem audition area evoked potential; and the content of the glucose and pyruvic acid in the cochlea were measured after the end of treatment. Results The content of the glucose: the impaired group is lower than the control group, the ( Ⅰ ) group is higher than the impaired group. The content of the pyruvic acid: the impaired group is different with all the other groups. The ratio of pyruvic acid/glucose:(Ⅰ)group and (Ⅲ) group both are lower than the impaired group, the impaired group is higher than the control group. The hearing impairment of (Ⅰ) group is 12.5dB(A), while that of (Ⅲ) group is only 2.5dB(A). Conclusion Treating the noise-induced hearing impairment with hyperbaric oxygen has a definite curative effect, the hyperbaric oxygen and radix salviae miltiorrhiza

  2. Continuous oxygen therapy for hypoxic pulmonary disease

    DEFF Research Database (Denmark)

    Ringbaek, Thomas J

    2005-01-01

    Continuous oxygen therapy (COT) has become widely accepted in the last 20 years in patients with continuous hypoxemia. This review focuses on guidelines for COT, adherence to these guidelines, and the effect of COT on survival, hospitalization, and quality of life. Guidelines for COT are mainly...

  3. Investigation of hyperbaric oxygenation medicine development in Hunan province of China%湖南省高压氧医学发展现状调查

    Institute of Scientific and Technical Information of China (English)

    杨阿莉; 彭争荣; 祖映翔; 肖平田; 刘敏

    2016-01-01

    Objective To know the development status of hyperbaric oxygen(HBO)medical discipline in Hunan Province.Methods Questionnaire,field survey,panel discussion,interview and the other methods were used to know human resources,equipments and facilities,medical treatment,teaching,research and other matters related to HBO medicine in this investigation.Results There are totally 288 hospitals at all levels carrying out HBO therapy provincially.Among them,municipal and county hospitals account for 34.0% and 55.9% respectively.The number of healthcare practitioners for HBO is 956.As for physician,junior and intermediate staff take up 41.8% and 35.7% respectively.Approximately two thirds of nurses are intermediate (63.1%).The largest part of technician is occupied by primary (68.8%).74.8% of physicians graduated as bachelor,however,most of nurses(66.0%)and technicians(75.8%)only have diploma below the bachelor level.Among 407 medical oxygen cabins in Hunan Province,air compression chambers (ACC)account for 45.4%.71.5% medical units within our survey use HBO.Annual income achieve 100-200 thousand for HBO therapy in 71.2% hospitals.86.1% hospitals are carrying out less than 5 HBO programs.HBO is established as a independent discipline in 20.83% hospitals.HBO special clinic service is set up in 25.0% hospitals while HBO special ward is not set up in any hospitals.In the recent 5 years,there were 33 research subjects about HBO,and 88 papers were published,and teaching subjects existed in only 6 medical units.The awareness rate of HBO is only 11.2% in non-medical staff.Conclusions The popularization of HBO medicine is fairly limited in Hunan Province presently.Research and teaching of HBO medicine is weak and social awareness is low.At the same time,allocation of human resource in HBO discipline is unreasonable,the distribution and type composition ratio of the HBO equipment are not uniform.For HBO,the configuration of clinical application is not perfect,the application is passive

  4. Effects of hyperbaric oxygen on diaphragmatic damage induced by sepsis in rats%高压氧对脓毒症大鼠膈肌损伤的保护作用

    Institute of Scientific and Technical Information of China (English)

    刘培; 周青山; 李彬彬; 张红梅; 李灵丰; 李厚成

    2010-01-01

    Objective To study protective effects of hyperbaric oxygen (HBO) on diaphragmatic damage induced by sepsis in rats. Methods Thirty SD rats were randomly divided into 3 groups: group A (the sham group, n = 10), group B (the sepsis group, n = 10) and group C (the HBO-treatment group, n = 10). Rats of group A were administered abdominal operation, and were then sutured following chloral hydrate anesthesia. For animals in group B and C, the sepsis rat model was developed with cecal ligation and puncture, and rats of group C were immediately treated with HBO. All the animals were sacrificed 16 hours after operation. Then, the left diaphragnmtic muscle was taken to treasure muscular contractility and the fight one to detect concentrations of MDA and SOD. Apoptosis of diaphragnmtic muscle cells and the pathological section examination were also made. Results Concentrations of MDA and rate of diaphragmatic muscle cell apoptosis of group B increased markedly, when compared with those of group A, while SOD concentration and muscular contractility of group B decreased significantly than those of group A, with a marked statistical difference (P < 0.01). Following HBO therapy, concentrations of MDA, SOD, diaphragmatic muscle cell apoptosis rate and muscular contractifity recovered obviously, with obvious statistical differences, when compsrisons were made between the two (P<0.01). Conclusions HBO could effectively inhibit formation of oxygen free radicals, reduce oxidative stress and the level of diaphragmatic injury in sepsis.%目的 观察高压氧(hyperbaric oxygen,HBO)对大鼠脓毒症时膈肌损伤的保护作用.方法 SPF级成年雄性SD大鼠30只,随机分为假手术组、脓毒症组及HBO治疗组,每组10只.其中假手术组在给予水合氯醛麻醉成功后,从正中线剪开大鼠腹部,然后缝合伤口.脓毒症组和HBO组在麻醉成功后.使用盲肠结扎穿刺(CLP)模型,将大鼠制成脓毒症动物模型,并且HBO组在术后立即

  5. Hyperbaric oxygen therapy or hydroxycobalamin attenuates surges in brain interstitial lactate and glucose; and hyperbaric oxygen improves respiratory status in cyanide-intoxicated rats

    DEFF Research Database (Denmark)

    Lawson-Smith, P; Olsen, Niels Vidiendal; Hyldegaard, O

    2011-01-01

    to four groups receiving potassium CN (KCN) 5.4 mg/kg or vehicle intra-arterially: 1) vehicle-treated control rats; 2) KCN-poisoned rats; 3) KCN-poisoned rats receiving hydroxycobalamin (25 mg); and 4) KCN-poisoned rats treated with HBO2 (284 kPa for 90 minutes). KCN alone caused a prompt increase...

  6. Oxygen therapy for acute myocardial infarction.

    Science.gov (United States)

    Cabello, Juan B; Burls, Amanda; Emparanza, José I; Bayliss, Susan E; Quinn, Tom

    2016-12-19

    Oxygen (O2) is widely used in people with acute myocardial infarction (AMI). Previous systematic reviews concluded that there was insufficient evidence to know whether oxygen reduced, increased or had no effect on heart ischaemia or infarct size. Our first Cochrane review in 2010 also concluded there was insufficient evidence to know whether oxygen should be used. Since 2010, the lack of evidence to support this widely used intervention has attracted considerable attention, prompting further trials of oxygen therapy in myocardial infarction patients. It is thus important to update this Cochrane review. To assess the effects of routine use of inhaled oxygen for acute myocardial infarction (AMI). We searched the following bibliographic databases on 6 June 2015: the Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library, MEDLINE (OVID), Embase (OVID), CINAHL (EBSCO) and Web of Science (Thomson Reuters). LILACS (Latin American and Caribbean Health Sciences Literature) was last searched in September 2016. We also contacted experts to identify eligible studies. We applied no language restrictions. Randomised controlled trials in people with suspected or proven AMI (ST-segment elevation myocardial infarction (STEMI) or non-STEMI) within 24 hours after onset, in which the intervention was inhaled oxygen (at normal pressure) compared to air, regardless of co-therapies provided to participants in both arms of the trial. Two authors independently reviewed the titles and abstracts of identified studies to see if they met the inclusion criteria and independently undertook the data extraction. We assessed the quality of studies and the risk of bias according to guidance in the Cochrane Handbook for Systematic Reviews of Interventions. The primary outcome was death. The measure of effect used was the risk ratio (RR) with a 95% confidence interval (CI). We used the GRADE approach to evaluate the quality of the evidence and the GRADE profiler (GRADEpro) to

  7. Hyperbaric oxygen promotes osteogenic differentiation of bone marrow stromal cells by regulating Wnt3a/β-catenin signaling—An in vitro and in vivo study

    Directory of Open Access Journals (Sweden)

    Song-Shu Lin

    2014-01-01

    Full Text Available We hypothesized that the effect of hyperbaric oxygen (HBO on bone formation is increased via osteogenic differentiation of bone marrow stromal cells (BMSCs, which is regulated by Wnt3a/β-catenin signaling. Our in vitro data showed that HBO increased cell proliferation, Wnt3a production, LRP6 phosphorylation, and cyclin D1 expression in osteogenically differentiated BMSCs. The mRNA and protein levels of Wnt3a, β-catenin, and Runx2 were upregulated while those of GSK-3β were downregulated after HBO treatment. The relative density ratio (phospho-protein/protein of Akt and GSK-3β was both up-regulated while that of β-catenin was down-regulated after HBO treatment. We next investigated whether HBO affects the accumulation of β-catenin. Our Western blot analysis showed increased levels of translocated β-catenin that stimulated the expression of target genes after HBO treatment. HBO increased TCF-dependent transcription, Runx2 promoter/Luc gene activity, and the expression of osteogenic markers of BMSCs, such as alkaline phosphatase activity, type I collagen, osteocalcin, calcium, and the intensity of Alizarin Red staining. HBO dose dependently increased the bone morphogenetic protein (BMP2 and osterix production. We further demonstrated that HBO increased the expression of vacuolar-ATPases, which stimulated Wnt3a secretion from BMSCs. Finally, we showed that the beneficial effects of HBO on bone formation were related to Wnt3a/β-catenin signaling in a rabbit model by histology, mechanical testing, and immunohistochemical assays. Accordingly, we concluded that HBO increased the osteogenic differentiation of BMSCs by regulating Wnt3a secretion and signaling.

  8. Hyperbaric oxygen protects mandibular condylar chondrocytes from interleukin-1β-induced apoptosis via the PI3K/AKT signaling pathway

    Science.gov (United States)

    Chen, Hang; Wu, Gaoyi; Sun, Qi; Dong, Yabing; Zhao, Huaqiang

    2016-01-01

    Objectives: Mandibular condylar chondrocyte apoptosis is mainly responsible for the development and progression of temporomandibular joint osteoarthritis (TMJ-OA). Interleukin-1β (IL-1β) generally serves an agent that induces chondrocyte apoptosis. Hyperbaric oxygen (HBO) treatment increases proteoglycan synthesis in vivo. We explore the protective effect of HBO on IL-1β-induced mandibular condylar chondrocyte apoptosis in rats and the potential molecular mechanisms. Methods: Chondrocytes were isolated from the TMJ of 3-4-week old Sprague-Dawley rats. The Cell Counting Kit-8 (CCK-8) assay was used to determine cell viability. The phosphorylated phosphoinositide-3 kinase (p-PI3K), phosphorylated AKT (p-Akt), type II collagen (COL2), and aggrecan (AGG) content was detected by immunofluorescence, immunocytochemistry and western blotting. The expression of Pi3k, Akt, Col2 and Agg mRNA was measured using real-time quantitative polymerase chain reaction (RT-qPCR). Results: HBO inhibited the cytotoxicity and apoptosis induced by IL-1β (10 ng/mL) in the mandibular condylar chondrocytes. HBO also decreased the IL-1β activity that decreased p-PI3K and p-AKT levels, and increased COL2 and AGG expression, with the net effect of suppressing extracellular matrix degradation. Conclusions: These data suggest that HBO may protect mandibular condylar chondrocytes against IL-1β-induced apoptosis via the PI3K/AKT signaling pathway, and that it may promote the expression of mandibular condylar chondrocyte extracellular matrix through the PI3K/AKT signaling pathway. PMID:27904712

  9. Phase II Trial of Radiotherapy After Hyperbaric Oxygenation With Multiagent Chemotherapy (Procarbazine, Nimustine, and Vincristine) for High-Grade Gliomas: Long-Term Results

    Energy Technology Data Exchange (ETDEWEB)

    Ogawa, Kazuhiko, E-mail: kogawa@med.u-ryukyu.ac.jp [Department of Radiology, University of the Ryukyu